Unresolved ER Stress Inflames the Intestine.
Intestinal epithelial cells interact with both microbes in the gut lumen and host immune cells. In this issue, Kaser et al. (2008) link a key mediator of endoplasmic reticulum stress, the protein XBP1, with survival of intestinal secretory epithelial cells and inflammatory bowel disease.
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Averil
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Department of Medicine, University of California at San Francisco, San Francisco, CA 94143-0451, USA.
D000818:Animals; D004268:DNA-Binding Proteins / Q000276:immunology*; D004721:Endoplasmic Reticulum / Q000276:immunology*; D004847:Epithelial Cells / Q000166:cytology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics* / Q000276:immunology; D007413:Intestinal Mucosa / Q000166:cytology / Q000276:immunology*; D000071701:Regulatory Factor X Transcription Factors; D014157:Transcription Factors / Q000276:immunology*; D000071717:X-Box Binding Protein 1
D004268:DNA-Binding Proteins; D000071701:Regulatory Factor X Transcription Factors; D014157:Transcription Factors; D000071717:X-Box Binding Protein 1; C000605543:XBP1 protein, human