title: Thymidine analogs as potential antiviral agents.
abstract: A dideoxythymidine analog, viz. 3'-N, N-dimethyl-2'-3'-dideoxythymidine (3) and its 5'-O-carboxyl ester prodrug derivatives (4-6) have been synthesized as probable antiviral agents. All these compounds have shown low to moderate level of antiviral activities against HIV, HSV 1 & 2, reovirus and many others.
authors.affiliation: Nucleic Acids Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad-211002, India.
authors.forename: Dipti
authors.initials: D
authors.lastname: Yadav
authors.forename: Diwakar
authors.initials: D
authors.lastname: Rai
authors.forename: J
authors.initials: J
authors.lastname: Balzarini
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
authors.forename: Ramendra K
authors.initials: RK
authors.lastname: Singh
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D054306:Dideoxynucleotides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D011355:Prodrugs / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: C541618:3'-N,N-dimethyl-2',3'-dideoxythymidine; D000998:Antiviral Agents; D054306:Dideoxynucleotides; D011355:Prodrugs