A time and a place for nkx2-1 in interneuron specification and migration.
The homeobox transcription factor, Nkx2-1, plays multiple roles during forebrain development. Using restricted genetic ablation of Nkx2-1, in this issue of Neuron, Butt et al. show that Nkx2-1 in telencephalic progenitors regulates interneuron subtype specification, while Nóbrega-Pereira et al. demonstrate that postmitotic Nkx2-1 regulates migration and sorting of interneurons to the striatum or cortex by controlling the expression of the guidance receptor, Neuropilin-2.
Elias
Laura A B
LA
Institute for Regeneration Medicine, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA.
Potter
Gregory B
GB
Kriegstein
Arnold R
AR
D000818:Animals; D019521:Body Patterning; D002454:Cell Differentiation / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D007395:Interneurons / Q000145:classification / Q000502:physiology*; D051379:Mice; D009687:Nuclear Proteins / Q000502:physiology*; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors / Q000502:physiology*
C000614414:Nkx2-1 protein, mouse; D009687:Nuclear Proteins; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors
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