title: Central motor and sensory pathway involvement in an X-linked Charcot-Marie-Tooth family.
abstract: The aim of the present study was to investigate the subclinical involvement of the central nervous system (CNS) in an X-linked Charcot-Marie-Toth (CMTX) family.
  
  
  METHODS
  Seven subjects, all members of one family with a C.462T > G connexin 32 (Cx32) mutation were investigated by Blink reflex, Somatosensory evoked potentials (SEP) and Transcranial magnetic stimulation (TMS). There were five clinically symptomatic for CMT neuropathy (four male and one female) and two asymptomatic (female) subjects.
  
  
  RESULTS
  Subclinical CNS involvement was observed in all, symptomatic and asymptomatic subjects.
  
  
  CONCLUSIONS
  This is the largest CMTX neuropathy family investigated for CNS involvement. Electrophysiological involvement of the CNS in every examined member of this family was observed, raising the question of a more systematic involvement of the CNS in CMTX disease.
authors.affiliation: EMG Laboratory, Department of Neurology, University of Athens, Aeghinition Hospital, Greece. tzabelis@med.uoa.gr
authors.forename: T
authors.initials: T
authors.lastname: Zambelis
authors.forename: M
authors.initials: M
authors.lastname: Panas
authors.forename: P
authors.initials: P
authors.lastname: Kokotis
authors.forename: G
authors.initials: G
authors.lastname: Karadima
authors.forename: E
authors.initials: E
authors.lastname: Kararizou
authors.forename: N
authors.initials: N
authors.lastname: Karandreas
mesh_terms: D000328:Adult; D001767:Blinking / Q000235:genetics; D002490:Central Nervous System / Q000503:physiopathology*; D002607:Charcot-Marie-Tooth Disease / Q000235:genetics / Q000503:physiopathology*; D019054:Evoked Potentials, Motor / Q000235:genetics; D005073:Evoked Potentials, Somatosensory / Q000235:genetics; D005260:Female; D040181:Genetic Diseases, X-Linked / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D017354:Point Mutation; D050781:Transcranial Magnetic Stimulation