title: Quality of life beyond 6 months after diagnosis in older adults with acute myeloid leukemia.
abstract: Although intensive chemotherapy may improve survival in older people with acute myeloid leukemia (AML) without adverse cytogenetics, its impact on quality of life (QOL) is mixed and most patients complain of fatigue up to 6 months after diagnosis. Little information is available on longer-term QOL outcomes. We prospectively followed 20 patients age 60 or older with AML who provided QOL data more than 6 months after diagnosis. Over the first 6 months, there were clinically important improvements in global health, role function, social function, and emotional function. Physical function and cognitive function were stable over time. Over the next 6 months, social function and fatigue improved, and other domains remained stable. Achievement of complete remission appeared to be associated with improvements in global health, physical function, and role function without negatively affecting other health domains. This information may aid discussions with patients about treatment.
authors.affiliation: Division of General Internal Medicine & Clinical Epidemiology, University Health Network, Toronto, Canada. shabbir.alibhai@uhn.on.ca
authors.forename: Shabbir M H
authors.initials: SM
authors.lastname: Alibhai
authors.forename: Marc
authors.initials: M
authors.lastname: Leach
authors.forename: Vikas
authors.initials: V
authors.lastname: Gupta
authors.forename: George A
authors.initials: GA
authors.lastname: Tomlinson
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Brandwein
authors.forename: Fernando Suarez
authors.initials: FS
authors.lastname: Saiz
authors.forename: Mark D
authors.initials: MD
authors.lastname: Minden
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003071:Cognition; D004644:Emotions; D005221:Fatigue / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology* / Q000523:psychology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011788:Quality of Life; D012074:Remission Induction