title: Manganese superoxide dismutase gene Ala-9Val polymorphism might be related to the severity of abnormal involuntary movements in Korean schizophrenic patients.
abstract: OBJECTIVE
  This study examined whether the manganese superoxide dismutase (MnSOD) gene Ala-9Val single-nucleotide polymorphism (SNP) is associated with neuroleptic-induced tardive dyskinesia (TD) and the severity of the abnormal involuntary movements in Korean schizophrenic patients.
  
  
  METHODS
  We investigated whether the MnSOD gene Ala-9Val SNP is associated with TD in Korean schizophrenic patients with (n=83) and without (n=126) TD who were matched for exposure to antipsychotics and other relevant variables.
  
  
  RESULTS
  Logistic regression analysis revealed that being older (p=0.026) was a risk factor for TD, but that there was no significant association between MnSOD gene and TD. Abnormal involuntary movements were more severe in carriers of the Ala allele than in noncarriers (p=0.044).
  
  
  CONCLUSIONS
  These findings do not support that the MnSOD gene Ala-9Val SNP is associated with TD in Korean schizophrenic patients. However, this polymorphism might be related to the severity of abnormal involuntary movements in this population.
authors.affiliation: Department of Psychiatry, Korea University College of Medicine, Seoul, South Korea.
authors.forename: Seung-Gul
authors.initials: SG
authors.lastname: Kang
authors.forename: Jung-Eun
authors.initials: JE
authors.lastname: Choi
authors.forename: Hyonggin
authors.initials: H
authors.lastname: An
authors.forename: Young-Min
authors.initials: YM
authors.lastname: Park
authors.forename: Heon-Jeong
authors.initials: HJ
authors.lastname: Lee
authors.forename: Changsu
authors.initials: C
authors.lastname: Han
authors.forename: Yong-Ku
authors.initials: YK
authors.lastname: Kim
authors.forename: Seung-Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Sung Nam
authors.initials: SN
authors.lastname: Cho
authors.forename: Sook-Haeng
authors.initials: SH
authors.lastname: Joe
authors.forename: In-Kwa
authors.initials: IK
authors.lastname: Jung
authors.forename: Leen
authors.initials: L
authors.lastname: Kim
authors.forename: Min-Soo
authors.initials: MS
authors.lastname: Lee
mesh_terms: D000328:Adult; D000409:Alanine / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007723:Korea; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000209:etiology / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012559:Schizophrenia / Q000150:complications / Q000235:genetics; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D013482:Superoxide Dismutase / Q000235:genetics*; D014633:Valine / Q000235:genetics*
chemical_list: D013482:Superoxide Dismutase; D014633:Valine; D000409:Alanine