[Gene expression profiling in drug addicted brain].
Drug addiction, a chronic brain disease caused by interaction of in vitro drug toxification and in vivo gene susceptibility, has been widely studied but its underlining mechanism is so far been elucidated. A major goal in this field is to identify drug-induced molecular changes and their effects on brain function. By the advance of high throughput technologies in genomics and transcriptomics, the whole gene expression profile in addicted brain could be obtained and proved to be a very powerful tool to unclose the molecular mechanism underlying the addiction biology context. Here, we summarized the progress of serial analysis of gene expression (SAGE) and microarray, as well as their application in drug addiction.
Chen
Feng
F
Department of Forensic Sciences, Xi'an Jiaotong University School of Medicine, Xi'an 710061, China. chenfeng418@stu.xjtu.edu.cn
Li
Tao
T
Fan
Shuan-Liang
SL
Dang
Yong-Hui
YH
Chen
Teng
T
Yan
Chun-Xia
CX
D001921:Brain / Q000378:metabolism*; D019295:Computational Biology; D020869:Gene Expression Profiling / Q000379:methods*; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D019966:Substance-Related Disorders / Q000235:genetics*