title: Nodular lymphocyte-predominant hodgkin lymphoma or T-cell/histiocyte rich large B-cell lymphoma: the problem in "grey zone" lymphomas.
abstract: Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare indolent B-cell lymphoma. However, its morphology can resemble T-cell/histiocyte rich large B-cell lymphoma (T/HRBCL), a subtype of more aggressive diffuse large B-cell lymphoma. More and more studies suggest that these two entities are closely related. In this report, a 59-year-old man with nodal NLPHL and concomitant T/HRBCL in the bone marrow is presented, the current progress in our understanding of these two closely related B-cell lymphomas reviewed and the problems in the diagnosis and differentiation of NLPHL and T/HRBCL discussed.
authors.affiliation: Department of Pathology, University of Maryland School of Medicine Baltimore, MD, USA.
authors.forename: Frank X
authors.initials: FX
authors.lastname: Zhao
references.citation: J Clin Oncol. 1999 Mar;17(3):776-83
references.pmid: 10071266
references.citation: Blood. 2003 Nov 15;102(10):3753-8
references.pmid: 12881319
references.citation: Ann Oncol. 1998;9 Suppl 5:S31-8
references.pmid: 9926235
references.citation: Mod Pathol. 1995 Jun;8(5):544-7
references.pmid: 7675775
references.citation: APMIS. 1995 Sep;103(9):655-62
references.pmid: 7488387
references.citation: Am J Surg Pathol. 1988 Aug;12(8):599-606
references.pmid: 3041849
references.citation: Am J Pathol. 2001 Nov;159(5):1807-14
references.pmid: 11696441
references.citation: Eur J Haematol Suppl. 2005 Jul;(66):42-4
references.pmid: 16007867
references.citation: Blood. 1995 Sep 15;86(6):2312-20
references.pmid: 7662978
references.citation: Blood. 2003 Jan 15;101(2):706-10
references.pmid: 12393409
references.citation: N Engl J Med. 1997 Aug 14;337(7):453-8
references.pmid: 9250847
references.citation: Blood. 1996 Jul 15;88(2):657-66
references.pmid: 8695813
references.citation: J Pathol. 2006 Feb;208(3):423-30
references.pmid: 16353293
references.citation: Ann Oncol. 2002;13 Suppl 1:44-51
references.pmid: 12078902
references.citation: Am J Surg Pathol. 2006 May;30(5):585-92
references.pmid: 16699312
references.citation: Am J Surg Pathol. 1984 Apr;8(4):253-61
references.pmid: 6369997
references.citation: Hematology Am Soc Hematol Educ Program. 2006;:266-72
references.pmid: 17124071
references.citation: Leuk Res. 2004 Mar;28(3):229-36
references.pmid: 14687617
references.citation: Leuk Lymphoma. 2004 Aug;45(8):1551-7
references.pmid: 15370206
references.citation: Histopathology. 1991 Sep;19(3):211-20
references.pmid: 1655614
references.citation: Am J Surg Pathol. 1994 May;18(5):526-30
references.pmid: 8172327
references.citation: N Engl J Med. 1997 Aug 14;337(7):459-65
references.pmid: 9250848
references.citation: Eur J Haematol Suppl. 2005 Jul;(66):106-10
references.pmid: 16007877
references.citation: J Clin Oncol. 1995 Jul;13(7):1742-50
references.pmid: 7602364
references.citation: Am J Clin Pathol. 2006 Nov;126(5):805-14
references.pmid: 17050078