Bilateral deep brain stimulation of the globus pallidus internus in tardive dystonia.
Tardive dystonia is a disabling movement disorder as a consequence of exposure to neuroleptic drugs. We followed 6 patients with medically refractory tardive dystonia treated by bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) for 21 +/- 18 months. At last follow-up, the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) motor score improved by 86% +/- 14%, and the BFMDRS disability score improved by 80% +/- 12%. Bilateral GPi-DBS is a beneficial therapeutic option for the long-term relief of tardive dystonia.
Sako
Wataru
W
Department of Clinical Neuroscience, Institute of Health Biosciences, Graduate School of Medicine, University of Tokushima, Tokushima, Japan.
Goto
Satoshi
S
Shimazu
Hideki
H
Murase
Nagako
N
Matsuzaki
Kazuhito
K
Tamura
Tetsuya
T
Mure
Hideo
H
Tomogane
Yusuke
Y
Arita
Norio
N
Yoshikawa
Hiroo
H
Nagahiro
Shinji
S
Kaji
Ryuji
R
D000328:Adult; D001703:Biophysics; D046690:Deep Brain Stimulation / Q000379:methods*; D004421:Dystonia / Q000628:therapy*; D005260:Female; D005917:Globus Pallidus / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome