Colonic involvement in a patient with chronic lymphocytic leukaemia.
Various gastrointestinal infiltrations have been described in patients with chronic lymphocytic leukaemia (CLL). Here, we report a 69-year-old man with CLL and anaemia in whom the macroscopic finding of colonoscopy was normal, but the histological specimens revealed lymphocytic leukemia in ileum and in colon. If a CLL patient has any symptoms suggesting a possible GI manifestation of the haematologic disease or anaemia not explained by bone marrow infiltration or hemolysis, the diagnostic evaluation should include endoscopies with adequate biopsies.
Arkkila
P E T
PE
Department of Gastroenterology, Helsinki University Central Hospital, 00290 Helsinki, Finland. perttu.arkkila@fimnet.fi
Nuutinen
H
H
Ebeling
F
F
Elonen
E
E
Kärkkäinen
P
P
Karjalainen-Lindsberg
M-L
ML
Clin Lab Haematol. 1996 Sep;18(3):215-7
8939393
Leukemia. 1997 Apr;11 Suppl 2:S50-1
9178840
Acta Gastroenterol Belg. 2003 Oct-Dec;66(4):303-6
14989055
Am J Pathol. 1997 Nov;151(5):1361-9
9358762
Dis Colon Rectum. 1986 Mar;29(3):191-5
3943435
J Clin Oncol. 2005 Feb 20;23(6):1315-7
15718331
J Gastroenterol. 2004;39(5):479-83
15175948
Am J Gastroenterol. 1995 Apr;90(4):635-7
7717324
J Med. 1998;29(3-4):237-40
9865461
Am J Dig Dis. 1977 Nov;22(11):1028-32
920701
J Clin Pathol. 1990 Jan;43(1):57-9
2312752
Cancer. 1999 Nov 1;86(9):1720-3
10547544
Jpn J Clin Oncol. 1988 Dec;18(4):335-42
3204683
JAMA. 1975 Apr 21;232(3):267-9
47401
Blood. 2000 Mar 15;95(6):1900-10
10706853
Am J Pathol. 2003 Jan;162(1):105-13
12507894
Am J Pathol. 1998 Dec;153(6):1701-5
9846960
Tumori. 1980 Aug 31;66(4):431-7
7414709
Curr Opin Gastroenterol. 2005 Jan;21(1):80-4
15687889