title: A pooled analysis of melanocytic nevus phenotype and the risk of cutaneous melanoma at different latitudes.
abstract: An abnormal nevus phenotype is associated with an increased risk of melanoma. We report a pooled analysis conducted using individual nevus data from 15 case-control studies (5,421 melanoma cases and 6,966 controls). The aims were to quantify the risk better and to determine whether relative risk is varied by latitude. Bayesian unconditional logistic random coefficients models were employed to study the risk associated with nevus characteristics. Participants with whole body nevus counts in the highest of 4 population-based categories had a greatly increased risk of melanoma compared with those in the lowest category (pooled odds ratio (pOR) 6.9 (95% confidence interval (CI): 4.4, 11.2) for those aged<50 years and pOR 5.1 (95% CI: 3.6, 7.5) for those aged>or=50). The pOR for presence compared with absence of any clinically atypical nevi was 4.0 (95% CI: 2.8, 5.8). The pORs for 1-2 and >or=3 large nevi on the body compared with none were 2.9 (95% CI: 1.9, 4.3) and 7.1 (95% CI: 4.7, 11.6), respectively. The relative heterogeneities among studies were small for most measures of nevus phenotype, except for the analysis of nevus counts on the arms, which may have been due to methodological differences among studies. The pooled analysis also suggested that an abnormal nevus phenotype is associated most with melanomas on intermittently sun-exposed sites. The presence of increased numbers of nevi, large nevi and clinically atypical nevi on the body are robust risk factors for melanoma showing little variation in relative risk among studies performed at different latitudes.
authors.affiliation: Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Leeds, United Kingdom. y.chang@leeds.ac.uk
authors.forename: Yu-mei
authors.initials: YM
authors.lastname: Chang
authors.forename: Julia A
authors.initials: JA
authors.lastname: Newton-Bishop
authors.forename: D Timothy
authors.initials: DT
authors.lastname: Bishop
authors.forename: Bruce K
authors.initials: BK
authors.lastname: Armstrong
authors.forename: Veronique
authors.initials: V
authors.lastname: Bataille
authors.forename: Wilma
authors.initials: W
authors.lastname: Bergman
authors.forename: Marianne
authors.initials: M
authors.lastname: Berwick
authors.forename: Paige M
authors.initials: PM
authors.lastname: Bracci
authors.forename: J Mark
authors.initials: JM
authors.lastname: Elwood
authors.forename: Marc S
authors.initials: MS
authors.lastname: Ernstoff
authors.forename: Adèle C
authors.initials: AC
authors.lastname: Green
authors.forename: Nelleke A
authors.initials: NA
authors.lastname: Gruis
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Holly
authors.forename: Christian
authors.initials: C
authors.lastname: Ingvar
authors.forename: Peter A
authors.initials: PA
authors.lastname: Kanetsky
authors.forename: Margaret R
authors.initials: MR
authors.lastname: Karagas
authors.forename: Loïc
authors.initials: L
authors.lastname: Le Marchand
authors.forename: Rona M
authors.initials: RM
authors.lastname: Mackie
authors.forename: Håkan
authors.initials: H
authors.lastname: Olsson
authors.forename: Anne
authors.initials: A
authors.lastname: Østerlind
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Rebbeck
authors.forename: Kristian
authors.initials: K
authors.lastname: Reich
authors.forename: Peter
authors.initials: P
authors.lastname: Sasieni
authors.forename: Victor
authors.initials: V
authors.lastname: Siskind
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Swerdlow
authors.forename: Linda
authors.initials: L
authors.lastname: Titus-Ernstoff
authors.forename: Michael S
authors.initials: MS
authors.lastname: Zens
authors.forename: Andreas
authors.initials: A
authors.lastname: Ziegler
authors.forename: Jennifer H
authors.initials: JH
authors.lastname: Barrett
mesh_terms: D000328:Adult; D001499:Bayes Theorem; D016022:Case-Control Studies; D005260:Female; D005843:Geography; D006801:Humans; D008297:Male; D008545:Melanoma / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D008875:Middle Aged; D009508:Nevus, Pigmented / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology*; D010641:Phenotype; D015203:Reproducibility of Results; D012307:Risk Factors; D012878:Skin Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D013472:Sunlight
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