title: Quality of life, anxiety and depression in sarcoidosis.
abstract: OBJECTIVE
  This study sought to evaluate the quality of life and the presence of psychiatric disorders in patients with sarcoidosis.
  
  
  METHODS
  Data were collected from 80 consecutive outpatients with sarcoidosis presenting to the Sarcoidosis Center of the Respiratory Diseases Division at the University of Siena, Italy.
  
  
  RESULTS
  Forty-four percent of the subjects endorsed at least one psychiatric DSM-IV axis I diagnosis. Specifically, 25% of subjects met the criteria for Major Depressive Disorder, 6.3% for Panic Disorder, 6.3% for Bipolar Disorder, 5% for Generalized Anxiety Disorder and 1.3% for Obsessive Compulsive Disorder. Statistically significant correlations were found between Forced Expiratory Volume in the first second (FEV(1)), Forced Vital Capacity (FVC) and several domains of the Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q) questionnaire. Subjects with multi-systemic involvement, with asthenia and with a more severe radiographic stage and subjects receiving steroids, reported a poorer quality of life.
  
  
  CONCLUSIONS
  Sarcoidosis is associated with a high rate of psychiatric comorbidity and may contribute to a poorer quality of life. A referral for a psychiatric or psychological evaluation and counseling should be considered for many of the sarcoidosis patients.
authors.affiliation: Psychiatry Division, Department of Neuroscience, University of Siena School of Medicine, Viale Bracci 1, 53100 Siena, Italy. goracci3@unisi.it
authors.forename: Arianna
authors.initials: A
authors.lastname: Goracci
authors.forename: Andrea
authors.initials: A
authors.lastname: Fagiolini
authors.forename: Mirko
authors.initials: M
authors.lastname: Martinucci
authors.forename: Sara
authors.initials: S
authors.lastname: Calossi
authors.forename: Serena
authors.initials: S
authors.lastname: Rossi
authors.forename: Tonino
authors.initials: T
authors.lastname: Santomauro
authors.forename: Angela
authors.initials: A
authors.lastname: Mazzi
authors.forename: Francesco
authors.initials: F
authors.lastname: Penza
authors.forename: Antonella
authors.initials: A
authors.lastname: Fossi
authors.forename: Elena
authors.initials: E
authors.lastname: Bargagli
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Pieroni
authors.forename: Paola
authors.initials: P
authors.lastname: Rottoli
authors.forename: Paolo
authors.initials: P
authors.lastname: Castrogiovanni
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology; D000328:Adult; D001008:Anxiety Disorders / Q000175:diagnosis* / Q000523:psychology; D001247:Asthenia / Q000175:diagnosis / Q000523:psychology; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000523:psychology; D003865:Major Depressive Disorder / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000523:psychology; D016584:Panic Disorder / Q000175:diagnosis / Q000523:psychology; D011788:Quality of Life / Q000523:psychology*; D012507:Sarcoidosis / Q000175:diagnosis / Q000523:psychology*; D017565:Sarcoidosis, Pulmonary / Q000175:diagnosis / Q000523:psychology*; D012803:Sick Role; D014797:Vital Capacity