title: Treatment of postmenopausal osteoporosis in women: a systematic review.
abstract: Osteoporosis, a typical disease of the elderly, has become a frequent and relevant public health problem. Several drugs are available for treatment of osteoporosis, some of which are currently dispensed by the Brazilian Unified National Health System. The objective of this study was to present a systematic review of drugs for treatment of osteoporosis, focusing on the adequacy of clinical protocols based on existing evidence in the scientific literature. We conducted a search for randomized clinical trials in PubMed and LILACS that presented results for bone mineral density, incidence of vertebral fractures, and adverse effects. 32 articles met the review's inclusion criteria. Bisphosphonates were reported to have consistently reduced the risk of vertebral fractures. Hormone replacement therapy showed positive outcomes, but its use has been found to increase the risk of cardiovascular disease and breast cancer. Teriparatide and monofluorophosphate also showed efficacy against osteoporosis. Calcium and vitamin D were given to patients as food supplements.
authors.affiliation: Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil. crisruasbrandao@yahoo.com.br
authors.forename: Cristina Mariano Ruas
authors.initials: CM
authors.lastname: Brandão
authors.forename: Marina Guimarães
authors.initials: MG
authors.lastname: Lima
authors.forename: Anderson Lourenço da
authors.initials: AL
authors.lastname: Silva
authors.forename: Graziele Dias
authors.initials: GD
authors.lastname: Silva
authors.forename: Augusto Afonso
authors.initials: AA
authors.lastname: Guerra
authors.forename: Francisco de Assis
authors.initials: Fde A
authors.lastname: Acúrcio
mesh_terms: D019386:Alendronate / Q000627:therapeutic use; D015519:Bone Density; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D004164:Diphosphonates / Q000627:therapeutic use*; D005260:Female; D050723:Fractures, Bone / Q000517:prevention & control; D020249:Hormone Replacement Therapy / Q000009:adverse effects; D006801:Humans; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D019386:Alendronate