title: Role of TGF-beta in the tumor stroma.
abstract: Recent findings have demonstrated that the tumor stroma actively contributes to tumorigenesis. The communication of malignant cells and tumor stromal components is orchestrated in part by a network of growth factors. One of these growth factors is transforming growth factor-beta (TGF-beta), a secreted multifunctional protein that acts in a highly cellular contextual manner. TGF-beta can either stimulate or inhibit the tumor-promoting effects of the different components of the tumor stroma. In this review, we discuss our current understanding on how TGF-beta influences different stromal compartments.
authors.affiliation: Department of Molecular Cell Biology, Leiden University Medical Centre, Postbus 9600, 2300 RC Leiden, The Netherlands.
authors.forename: H P H
authors.initials: HP
authors.lastname: Naber
authors.forename: P
authors.initials: P
authors.lastname: ten Dijke
authors.forename: E
authors.initials: E
authors.lastname: Pardali
mesh_terms: D006801:Humans; D009369:Neoplasms / Q000098:blood supply / Q000276:immunology / Q000473:pathology*; D009389:Neovascularization, Pathologic; D015398:Signal Transduction; D017154:Stromal Cells / Q000473:pathology*; D016212:Transforming Growth Factor beta / Q000378:metabolism / Q000502:physiology*
chemical_list: D016212:Transforming Growth Factor beta