title: Drug-related hepatotoxicity and hepatic failure following combined androgen blockade.
abstract: Androgen deprivation therapy has been the mainstay of treatment for metastatic prostate cancer and of less advanced cancers as neoadjuvant and adjuvant treatment. Abnormal liver function test, in particular elevated transaminases, is an adverse reaction more frequently noticed during androgen deprivation therapy with antiandrogen. We report the case of a patient with acute hepatic failure associated with the use of bicalutamide.
authors.affiliation: Department of Radiation Oncology, Hospital Punta de Europa, Algeciras, Cádiz, Spain. icastro78@yahoo.es
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Castro Beza
authors.forename: Jesús
authors.initials: J
authors.lastname: Sánchez Ruiz
authors.forename: Francisco José
authors.initials: FJ
authors.lastname: Peracaula Espino
authors.forename: M Isabel
authors.initials: MI
authors.lastname: Villanego Beltrán
mesh_terms: D000726:Androgen Antagonists / Q000009:adverse effects*; D000813:Anilides / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D017809:Fatal Outcome; D006801:Humans; D017114:Liver Failure, Acute / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D009570:Nitriles / Q000009:adverse effects*; D011471:Prostatic Neoplasms / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D014105:Tosyl Compounds / Q000009:adverse effects*; D000637:Transaminases / Q000097:blood; D016896:Treatment Outcome
chemical_list: D000726:Androgen Antagonists; D000813:Anilides; D009570:Nitriles; D014105:Tosyl Compounds; C053541:bicalutamide; D000637:Transaminases
references.citation: J Hepatol. 1990 Sep;11(2):272-6
references.pmid: 2254635
references.citation: Prostate Suppl. 1994;5:27-33
references.pmid: 8172713
references.citation: Ann Intern Med. 1993 Jun 1;118(11):860-4
references.pmid: 7683180
references.citation: Cancer. 1996 Nov 15;78(10):2164-9
references.pmid: 8918410
references.citation: N Engl J Med. 2006 Feb 16;354(7):731-9
references.pmid: 16481640
references.citation: Urology. 1997 Feb;49(2):283-4
references.pmid: 9037299
references.citation: Gastroenterol Clin Biol. 1993;17(6-7):499-501
references.pmid: 8243938