Total syntheses of a North methanocarba puromycin analog and its dinucleotide derivative.
North methanocarba Puromycin analog 5 and its di-nucleotide derivative 6 were synthesized from D-ribose in respectively 18 and 19 steps, in order to be tested for peptidyl transfer efficiency in ribosomes.
Michel
Benoît Y
BY
Laboratoire de Synthèse de Biomolécules, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (UMR 5246), Université Claude Bernard Lyon 1, 69622, Villeurbanne, France. benoit.michel@yahoo.fr
Strazewski
Peter
P
D003562:Cytidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D011500:Protein Synthesis Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D011691:Puromycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
D011500:Protein Synthesis Inhibitors; D011691:Puromycin; D003562:Cytidine