Multi-break rearrangements and breakpoint re-uses: from circular to linear genomes.
Multi-break rearrangements break a genome into multiple fragments and further glue them together in a new order. While 2-break rearrangements represent standard reversals, fusions, fissions, and translocations, 3-break rearrangements represent a natural generalization of transpositions. Alekseyev and Pevzner (2007a, 2008a) studied multi-break rearrangements in circular genomes and further applied them to the analysis of chromosomal evolution in mammalian genomes. In this paper, we extend these results to the more difficult case of linear genomes. In particular, we give lower bounds for the rearrangement distance between linear genomes and for the breakpoint re-use rate as functions of the number and proportion of transpositions. We further use these results to analyze comparative genomic architecture of mammalian genomes.
Alekseyev
Max A
MA
Department of Computer Science and Engineering, University of California at San Diego, La Jolla, California 92093, USA. maxal@cs.ucsd.edu
D000818:Animals; D002875:Chromosomes / Q000737:chemistry / Q000235:genetics; D019295:Computational Biology / Q000379:methods; D004270:DNA, Circular / Q000235:genetics*; D015321:Gene Rearrangement; D016678:Genome; D023281:Genomics / Q000379:methods; D006801:Humans; D008322:Mammals / Q000235:genetics; D008957:Models, Genetic; D017422:Sequence Analysis, DNA
D004270:DNA, Circular