Live birth sex ratios are not influenced by blastocyst-stage embryo transfer.
OBJECTIVE
To analyze the sex ratio of infants born after blastocyst-stage transfer of embryos with normal preimplantation FISH genetic screening.


METHODS
Retrospective cohort analysis.


METHODS
Large academic assisted reproductive technology center.


METHODS
Two hundred twenty-eight patients undergoing fresh IVF cycle with blastocyst transfer.


METHODS
Preimplantation genetic screening for sex complement.


METHODS
Sex ratio in liveborn infants following blastocyst transfer.


RESULTS
One thousand thirteen embryos were normal by preimplantation genetic screening of chromosomes 13, 15, 16, 17, 18, 21, 22, X, and Y. Four hundred ninety-eight normal embryos were transferred to 228 patients with an overall live birth rate of 41.7%. Transferred blastocysts were selected based upon morphologic assessment. When controlling for the sex of the blastocyst embryo, there was no difference in the male-to-female delivery rate per embryo transferred (27.3% vs. 21.4%) (relative risk =1.28, confidence interval 0.93-1.74). Of the live births 51.7% were male and 48.3% were female (P=.61). Subanalysis revealed no difference in male-to-female delivery rates in groups with a 1:1 ratio of male:female embryos transferred, a non 1:1 ratio transferred, or single-sex transfers.


CONCLUSIONS
Blastocyst-stage embryo transfer does not influence the live birth sex ratio of embryos with normal preimplantation FISH genetic screening.
Csokmay
John M
JM
National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
Hill
Micah J
MJ
Blanchfield Army Community Hospital, Ft. Campbell, Kentucky.
Cioppettini
Frank V
FV
Reproductive Medicine Associates of New Jersey, Morristown, New Jersey.
Miller
Kathleen A
KA
Reproductive Medicine Associates of New Jersey, Morristown, New Jersey.
Scott
Richard T
RT
Reproductive Medicine Associates of New Jersey, Morristown, New Jersey.
Frattarelli
John L
JL
Reproductive Medicine Associates of New Jersey, Morristown, New Jersey. Electronic address: jfrattarelli@rmanj.com.
D000328:Adult; D001755:Blastocyst / Q000166:cytology*; D015331:Cohort Studies; D004624:Embryo Transfer / Q000379:methods*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D005820:Genetic Testing; D006801:Humans; D050498:Live Birth; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D012189:Retrospective Studies; D012744:Sex Ratio