Total synthesis of hyacinthacine A1, a glycosidase inhibitor.
A practical and enantioselective total synthesis of hyacinthacine A1 is achieved involving syn allylic epoxide opening with retention using Pd catalysis and "domino" hydrogenation (five steps in one pot) sequences.
Chandrasekhar
Srivari
S
Organic Division-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India. srivaric@iict.res.in
Parida
Bibhuti Bhusan
BB
Rambabu
Chegondi
C
D002384:Catalysis; D004852:Epoxy Compounds; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors*; D006865:Hydrogenation; D010165:Palladium; D011763:Pyrrolizidine Alkaloids / Q000138:chemical synthesis*; D013237:Stereoisomerism
D004852:Epoxy Compounds; D011763:Pyrrolizidine Alkaloids; C508850:hyacinthacine A1; D010165:Palladium; D006026:Glycoside Hydrolases