Expanding the chemical space in practice: diversity-oriented synthesis.
Diversity-Oriented Synthesis (DOS) aims to broaden the frontier of accessible collections of complex and diverse small molecules. This review endeavours to dissect the DOS concept through three elements of diversity: building block, stereochemistry, and skeleton. Recent examples in the literature that emphasize the efficient combinations of these elements to generate diversity are reported.
Peuchmaur
Marine
M
Département de Pharmacochimie Moléculaire, Université de Grenoble/CNRS UMR 5063, CNRS ICMG FR 2607 Bâtiment E, Bâtiment André Rassat, 470 rue de la Chimie, Grenoble Cedex 9, France.
Wong
Yung-Sing
YS
D015415:Biomarkers / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D015394:Molecular Structure; D015398:Signal Transduction; D013237:Stereoisomerism
D015415:Biomarkers