title: [Mycophenolate mofetil and cyclosporine in the treatment of steroid-dependent nephrotic syndrome with frequent relapses].
abstract: We describe the case of an 8-year-old patient, with steroid-dependent minimal lesion nephrotic syndrome, with frequent relapses despite treatment with cyclosporine. After the switch to mycophenolate mofetil the patient had new relapses, and there was difficulty in controlling the disease. The reintroduction of cyclosporine combined with mycophenolate mofetil obtained an optimal response, with a longer relapse-free time. Due to their kinetic variability, the blood levels of both drugs were closely monitored during follow-up.
authors.affiliation: Servicio de Farmacia, Hospital Universitario Dr. Peset, Valencia, España. marquez_juapei@gva.es
authors.forename: J F
authors.initials: JF
authors.lastname: Márquez Peiró
authors.forename: B
authors.initials: B
authors.lastname: Porta Oltra
authors.forename: J
authors.initials: J
authors.lastname: Marín Serra
mesh_terms: D002648:Child; D016572:Cyclosporine / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D009173:Mycophenolic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009404:Nephrotic Syndrome / Q000188:drug therapy*; D012008:Recurrence; D013256:Steroids; D013997:Time Factors
chemical_list: D007166:Immunosuppressive Agents; D013256:Steroids; D016572:Cyclosporine; D009173:Mycophenolic Acid