Design and synthesis of peptide-oligonucleotide conjugates as potential artificial ribonucleases.
A series of peptide-oligonucleotide conjugates was synthesized. The peptide fragment was attached to the middle part of DNA sequence. For this purpose the new amidophosphite dC with linker at C5-position was synthesized.
Serpokrylova
Inna
I
Institute of Chemical Biology and Fundamental Medicine, Siberian Division of Russian Academy of Sciences, Lavrent'ev ave. 8, Novosibirsk, Russia. inna_serpokrylova@biosset.com
Koroleva
Ludmila
L
Svischeva
Nadezhda
N
Novopashina
Daria
D
Silnikov
Vladimir
V
D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D017905:Phosphites / Q000138:chemical synthesis / Q000737:chemistry; D012260:Ribonucleases / Q000138:chemical synthesis* / Q000737:chemistry
D009838:Oligodeoxyribonucleotides; D009943:Organophosphorus Compounds; D010455:Peptides; D017905:Phosphites; C434331:phosphoramidite; D012260:Ribonucleases