title: 5-HT7 receptor stimulation by 8-OH-DPAT counteracts the impairing effect of 5-HT(1A) receptor stimulation on contextual learning in mice.
abstract: The principal 5-HT(1A) receptor agonist 8-Hydroxy-2-(dipropylamino)tetralin (8-OH-DPAT) impairs several different types of learning. Besides 5-HT(1A) receptors, 8-OH-DPAT stimulates 5-HT(7) receptors, but it is not known whether 5-HT(7) receptors contribute to the impairments. The 5-HT(7) receptor antagonist (2R)-1-[(3-Hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl] pyrrolidine (SB-269970) was combined with 8-OH-DPAT to dissociate 5-HT(1A) from 5-HT(7) receptor-mediated effects, in the passive avoidance task for emotional learning. SB-269970 intensified impairments caused by 8-OH-DPAT. SB-269970 alone had no effect on memory performance, but moderately decreased retention under suboptimal learning conditions. These findings indicate that 5-HT(7) receptor stimulation by 8-OH-DPAT counteracts 5-HT(1A) receptor-mediated impairments in hippocampal-dependent contextual learning.
authors.affiliation: Department of Neuroscience, Division of Behavioral Neuroscience, Karolinska Institute, Stockholm, Sweden.
authors.forename: Therese M
authors.initials: TM
authors.lastname: Eriksson
authors.forename: Armita
authors.initials: A
authors.lastname: Golkar
authors.forename: Joanna C
authors.initials: JC
authors.lastname: Ekström
authors.forename: Per
authors.initials: P
authors.lastname: Svenningsson
authors.forename: Sven Ove
authors.initials: SO
authors.lastname: Ogren
mesh_terms: D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D006624:Hippocampus / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011985:Receptors, Serotonin / Q000502:physiology*; D058825:Serotonin 5-HT1 Receptor Agonists; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*
chemical_list: D011985:Receptors, Serotonin; D058825:Serotonin 5-HT1 Receptor Agonists; D017366:Serotonin Receptor Agonists; C104425:serotonin 7 receptor; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin