title: [Pyogenic liver abscesses].
abstract: BACKGROUND
  Pyogenic liver abscesses were a relative rare disease. In the last decades the management of the liver abscesses was changed due to the new imaging and surgical techniques.
  
  
  OBJECTIVE
  To evaluate the clinical features, imaging techniques and treatment of the liver abscesses.
  
  
  METHODS
  We performed a retrospective study during the last twenty years (1987-2007). The patients were divided in two groups: group I treated during the period 1997-2007 and group II, 1987-1996. We compare the clinical features, biological tests, imaging techniques and the treatment.
  
  
  RESULTS
  Of the 71 patients with liver abscesses, 39 (54.9%) were included in group I and 32 (45.1%) in group II. The male/female ratio was 49/22; liver abscesses were more frequent to the males, in group I (63.3%) and more frequent to the women, in group II (63.6%) (p = 0.035). The mean age was 47.49 +/- 2.09 years old (range 18-85) with no difference between the groups (p = 0.059). The symptoms were similar in the two groups. We noted, as associated disease: diabetes--16% (N = 12), liver cirrhosis--7% (N = 5), malignancies--4.2% (N = 3). White blood cells were higher than 10000/mm3 in 51 patients (71.83%); a severe anemia with hemoglobin levels less than 10 g/dL was found in 25 cases (35.21%). All cases were investigated by ultrasound exam, but CT scan was performed in only 25 cases (19.71%). The abscesses were situated into the right lobe in 53 cases (74.6%), into the left lobe in 13 cases (18.3%) and into the both lobes in 5 patients (7%). The etiology was diverse: 25.4% after hepatic hydatid cysts, 12.7% with biliary origin, 22.5% with hematogenous and phlebitis origin and 39.4% with unknown origin (cryptogenetic). Treatment of the liver abscesses was surgical, by open (87.3%) or laparoscopic approach (8.5%), and percutaneous (ultrasound guided punction)--2.8%. One case was medical treated (antibiotherapy). Bacteriological exam found aerobic germs in 45 patients (64.28%), anaerobic germs in 3 patients (4.28%); the pus was sterile in 22 patients (31.43%). The intraoperative mean dimension of the liver abscesses was 74.26 +/- 4.35 mm (range 30-160), similar with dimensions measured by echography 72.29 +/- 4.84 mm (range 12-179)--p < 10(-3). Intraoperative bleeding was noted in 29 patients (40.8%). Univariate analysis revealed as prognosis factors for intraoperative bleeding, diameter of the liver abscess (p < 10(-3)), dimension of the residual cavity (p < 10(-3)) and the pus volume (p < 10(-3)). The multivariate analysis, by logistic regression, revealed as prognosis factors for intraoperative bleeding, pus volume (p = 0.006) and hemoglobin level (p = 0.035). Postoperative morbidity was 43.7%. Univariate analysis and logistic regression revealed the pleural effusion as prognosis factors for postoperative complications (p = 0.046) and, respectively, intraoperative hemorrhage (p = 0.010) and splenomegaly (p = 0.007). Postoperative mortality rate was 2.81%.
  
  
  CONCLUSIONS
  Pyogenic liver abscess is a challenging disease with high rate of postoperative morbidity. Most of the abscesses are unique and situated in the right lobe of the liver. The imaging techniques, especially ultrasound exam and CT-scan, are essential for the diagnosis and the treatment of liver abscesses. The treatment is usually surgical, by open or laparoscopic approach; in selected patients the percutaneous approach can be performed.
authors.affiliation: Clinica I Chirurgie I. Tănsescu-VI. Buţureanu, Spitalul Sf. Spiridon, Universitatea de Medicină si Farmacie Gr. T. Popa Iaşyi.2 Departamentul de radiologie, Spitalul "Sf. Spiridon" Iapi. etarco@iasi.mednet.ro
authors.forename: E
authors.initials: E
authors.lastname: Târcoveanu
authors.forename: N
authors.initials: N
authors.lastname: Vlad
authors.forename: R
authors.initials: R
authors.lastname: Moldovanu
authors.forename: S t
authors.initials: St
authors.lastname: Georgescu
authors.forename: C
authors.initials: C
authors.lastname: Bradea
authors.forename: C
authors.initials: C
authors.lastname: Lupaşu
authors.forename: Felicia
authors.initials: F
authors.lastname: Crumpei
authors.forename: A
authors.initials: A
authors.lastname: Vasilescu
authors.forename: V
authors.initials: V
authors.lastname: Strat
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001420:Bacteria, Aerobic / Q000302:isolation & purification; D001421:Bacteria, Anaerobic / Q000302:isolation & purification; D001424:Bacterial Infections / Q000150:complications / Q000601:surgery; D005260:Female; D006498:Hepatectomy; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D046290:Liver Abscess, Pyogenic / Q000175:diagnosis / Q000209:etiology / Q000266:history / Q000382:microbiology* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011677:Punctures / Q000379:methods; D012189:Retrospective Studies; D012383:Romania; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional / Q000379:methods