Treatment failure in Haemophilus influenzae due to a beta-lactamase low-level ampicillin-resistant organism.
Haemophilus influenzae is a rare causative organism of vertebral osteomyelitis in an adult. Cases reported in the literature were mainly caused by ampicillin-susceptible type b strains. Here we describe the first case of vertebral osteomyelitis due to a non-typeable, beta-lactamase low-level ampicillin-resistant H. influenzae strain with failure of prolonged intravenous amoxicillin treatment.
van der Ploeg
Vishnu
V
Department of Infectious Diseases, C5-P, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.
Gelinck
Luc B S
LB
Jonkers
Iris J A M
IJ
Mourer
Jacqueline S
JS
van Dam
Alje P
AP
D000368:Aged; D000658:Amoxicillin / Q000627:therapeutic use*; D000668:Ampicillin Resistance; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D006192:Haemophilus Infections / Q000188:drug therapy* / Q000382:microbiology; D006193:Haemophilus influenzae / Q000187:drug effects* / Q000201:enzymology / Q000302:isolation & purification; D006801:Humans; D008297:Male; D010019:Osteomyelitis / Q000188:drug therapy* / Q000382:microbiology; D017211:Treatment Failure; D001618:beta-Lactamases / Q000096:biosynthesis*
D000900:Anti-Bacterial Agents; D000658:Amoxicillin; D001618:beta-Lactamases