title: Utility of multivariate analysis in modeling the effects of raw material properties and operating parameters on granule and ribbon properties prepared in roller compaction.
abstract: This article aimed to model the effects of raw material properties and roller compactor operating parameters (OPs) on the properties of roller compacted ribbons and granules with the aid of principal component analysis (PCA) and partial least squares (PLS) projection. A database of raw material properties was established through extensive physical and mechanical characterization of several microcrystalline cellulose (MCC) and lactose grades and their blends. A design of experiment (DoE) was used for ribbon production. PLS models constructed with only OP-modeled roller compaction (RC) responded poorly. Inclusion of raw material properties markedly improved the goodness of fit (R(2) = .897) and model predictability (Q(2) = 0.72).
authors.affiliation: Department of Industrial and Physical Pharmacy, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West Lafayette, IN 47907, USA.
authors.forename: Josephine L P
authors.initials: JL
authors.lastname: Soh
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.forename: Nathan
authors.initials: N
authors.lastname: Boersen
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Pinal
authors.forename: Garnet E
authors.initials: GE
authors.lastname: Peck
authors.forename: M Teresa
authors.initials: MT
authors.lastname: Carvajal
authors.forename: James
authors.initials: J
authors.lastname: Cheney
authors.forename: Hedinn
authors.initials: H
authors.lastname: Valthorsson
authors.forename: Jim
authors.initials: J
authors.lastname: Pazdan
mesh_terms: D002482:Cellulose; D005079:Excipients; D007785:Lactose; D016018:Least-Squares Analysis; D015999:Multivariate Analysis; D025341:Principal Component Analysis; D013607:Tablets; D013678:Technology, Pharmaceutical
chemical_list: D005079:Excipients; D013607:Tablets; D002482:Cellulose; D007785:Lactose; C109691:microcrystalline cellulose