Oxidative stress in prehypertension: rationale for antioxidant clinical trials.
Prehypertension has been recently described as an independent category of blood pressure. Mounting evidence suggests that blood pressure in the prehypertensive range is associated with an increased risk of developing hypertension and cardiovascular disease. Several reports have assigned a critical role for oxidative stress in these disease processes. This review focuses on the clinical and experimental studies done in prehypertension and hypertension within the context of oxidative stress. This article also provides insights into why diverse therapeutic interventions, which have in common the ability to reduce oxidative stress, can impede or delay the onset of hypertension in prehypertension subjects.
Nambiar
Selvaraj
S
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry 605 006, India.
Viswanathan
Sathiyapriya
S
Zachariah
Bobby
B
Hanumanthappa
Nandeesha
N
Magadi
Sridhar Gopalakrishna
SG
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic / Q000379:methods*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism*; D018384:Oxidative Stress; D016896:Treatment Outcome
D000975:Antioxidants