title: Influence of diets varying in lipid and protein content on the histopathologic variety of murine salivary gland tumors induced by 9,10-dimethyl-1,2-benzanthracene (DMBA).
abstract: The purpose of this study was to analyze the influence of diets varying in lipids and proteins on the histopathologic variety of murine salivary tumors induced by DMBA. 117 BALB/c mice were assigned to experiments one (E1: lipids, males) and two (E2: proteins, males and females), E1 comprising Soy oil (SO); Corn oil (CO, control); Fish oil (FO) and Olein (O) groups and E2, soy protein (SP) and casein (C) groups. Tumors were induced by DMBA and the animals were sacrificed at week 13- post-induction. Tumor volume was calculated. Tumor sections were stained with H-E for histopathologic evaluation. No significant association was found between tumor volume and dietary condition (p > 0.05). In E1, FO animals developed mainly carcinomas (C) (58.8%), the sarcomas (S) and carcinosarcomas (CS) being especially of high-grade type (tumors < 600 mm3). In E2, SP animals developed mainly C (55.6%). Although no significantly different (p > 0.05), S and C were more frequent in female and male mice, respectively. In both E1 and E2, the biggest tumors (> 600 mm3) were mainly high-grade S (87.5%-80%). Dietary fat and soy protein appear to influence the tumor histopathology and thus its prognosis.
authors.affiliation: Instituto de Biología Celular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina. adractis@odo.unc.edu.ar
authors.forename: Adriana B
authors.initials: AB
authors.lastname: Actis
authors.forename: David C
authors.initials: DC
authors.lastname: Cremonezzi
authors.forename: Silvia
authors.initials: S
authors.lastname: Carino
authors.forename: Silvia
authors.initials: S
authors.lastname: Joekes
authors.forename: Mirta A
authors.initials: MA
authors.lastname: Valentich
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002273:Carcinogens; D002277:Carcinoma / Q000139:chemically induced / Q000473:pathology*; D002296:Carcinosarcoma / Q000139:chemically induced / Q000473:pathology; D002364:Caseins / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage*; D004044:Dietary Proteins / Q000008:administration & dosage*; D004195:Disease Models, Animal; D005260:Female; D008055:Lipids / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012468:Salivary Gland Neoplasms / Q000139:chemically induced / Q000473:pathology*; D030262:Soybean Proteins / Q000008:administration & dosage*; D047368:Tumor Burden
chemical_list: D002273:Carcinogens; D002364:Caseins; D004041:Dietary Fats; D004044:Dietary Proteins; D008055:Lipids; D030262:Soybean Proteins; D015127:9,10-Dimethyl-1,2-benzanthracene