[Abnormalities in renal hemodynamics].
Chronic kidney disease (CKD) is a major risk factor for the development of cardiovascular disease (CVD). Abnormalities of renal hemodynamics are associated with CKD. Abnormalities in renal hemodynamics include blood flow into glomeruli, and tubulointerstitial tissue. Renin-angiotensin system, oxidative stress and NOS system affect abnormalities of renal hemodynamics in CKD. Further, intrarenal hemodynamic abnormalities are strongly associated with systemic arteriosclerosis. Appropriate regulation of renal hemodynamics and controls of hypertension and diabetes mellitus retard the progression of both CKD and CVD.
Ueda
Hideki
H
Department of Nephrology, Osaka City University Graduate School of Medicine.
Ishimura
Eiji
E
D001161:Arteriosclerosis / Q000150:complications / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000209:etiology; D002908:Chronic Disease; D048909:Diabetes Complications; D006801:Humans; D006973:Hypertension / Q000150:complications; D007674:Kidney Diseases / Q000150:complications / Q000503:physiopathology*; D007678:Kidney Glomerulus / Q000098:blood supply; D007684:Kidney Tubules / Q000098:blood supply; D052250:Nitric Oxide Synthase Type III / Q000502:physiology; D018384:Oxidative Stress; D012039:Regional Blood Flow; D012079:Renal Circulation; D012084:Renin-Angiotensin System / Q000502:physiology; D012307:Risk Factors
D052250:Nitric Oxide Synthase Type III