First-year trends in self-reported general health predict survival in patients with head and neck cancer.
OBJECTIVE
To demonstrate that first-year trends in a self-reported subjective general health assessment tool can provide prognostic information and help predict long-term survival in patients with head and neck cancer.


METHODS
Prospective observational cohort study.


METHODS
Tertiary care center.


METHODS
Four hundred three patients with head and neck cancer who were enrolled in a longitudinal outcomes project between January 1, 1995, and December 31, 2005.


METHODS
Self-reported general physical health assessments were collected using the Medical Outcomes Study 36-Item Short-Form Health Survey at diagnosis (pretreatment) and at 3, 6, 9, and 12 months after diagnosis.


METHODS
Actuarial 5-year observed (all deaths) and disease-specific (death with cancer present) survival.


RESULTS
Mean physical component summary (PCS) scores decreased at 3 months in all patient groups. While patients who died within the second or third year exhibited virtually no recovery, those who died within the fourth or fifth year exhibited some recovery, and those who survived 5 years or longer approached baseline PCS scores by 12 months. Shorter survival correlated with a greater net decrease in PCS score at 12 months. Groups based on pretreatment and 12-month PCS scores had significantly different survival curves. The net change in PCS score at 12 months (DeltaPCS) was a predictor of both observed and disease-specific survival at univariate analysis and an independent predictor of disease-specific survival in multivariate analysis.


CONCLUSIONS
First-year trends in the 36-Item Short-Form Health Survey PCS score, a self-reported subjective measure of general physical health, are predictive of long-term survival.
Jameson
Mark J
MJ
Department of Otolaryngology-Head and Neck Surgery, University of Iowa College of Medicine, 200 Hawkins Dr, Room 21200 PFP, Iowa City, IA 52242-1093, USA.
Karnell
Lucy Hynds
LH
Christensen
Alan J
AJ
Funk
Gerry F
GF
D000368:Aged; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000523:psychology*; D006305:Health Status Indicators; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D015996:Survival Rate; D013997:Time Factors