title: Hyper- and hypoglycemia in children with community-acquired pneumonia.
abstract: Clinical conditions characterized by sufficient biological stress may be associated with hyperglycemia. The aim of the present study was to evaluate whether stress induced by community-acquired pneumonia (CAP) is associated with disturbances in glucose metabolism in children. Plasma glucose was measured in 108 children with CAP. The relationships between plasma glucose and clinical/laboratory characteristics of CAP were studied by multiple linear regression. The etiology of CAP was determined by serological methods. Plasma glucose level was 100.3 +/- 21.2 mg/dl (mean +/- SD). Only one patient developed hyperglycemia (167 mg/dl), and hypoglycemia (< 60 mg/dl) was present in four patients (3.7%). Plasma glucose had a significant association only with body temperature. Hyperglycemia was rare, about 1%, and the severity or etiology of CAP was not predictive for plasma glucose levels. However, about 4% of the patients had hypoglycemia, which could be explained by reduced calorie intake during acute infection or by the effect of stress-induced cytokines.
authors.affiliation: Pediatric Department, School of Medicine, DPMSC, University ofUdine, Italy. max.don@libero.it
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Don
authors.forename: Giuliana
authors.initials: G
authors.lastname: Valerio
authors.forename: Matti
authors.initials: M
authors.lastname: Korppi
authors.forename: Mario
authors.initials: M
authors.lastname: Canciani
mesh_terms: D000293:Adolescent; D000375:Aging / Q000502:physiology; D001786:Blood Glucose / Q000378:metabolism; D001831:Body Temperature; D002648:Child; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000097:blood / Q000150:complications*; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D007003:Hypoglycemia / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D007223:Infant; D018836:Inflammation Mediators / Q000097:blood; D007558:Italy / Q000453:epidemiology; D008297:Male; D011014:Pneumonia / Q000097:blood / Q000150:complications* / Q000382:microbiology; D018410:Pneumonia, Bacterial / Q000382:microbiology; D011024:Pneumonia, Viral / Q000821:virology; D011446:Prospective Studies; D012727:Sex Characteristics
chemical_list: D001786:Blood Glucose; D018836:Inflammation Mediators