title: Sleep symptoms and their clinical correlates in Machado-Joseph disease.
abstract: OBJECTIVE
  To evaluate the presence of sleep symptoms in Machado-Joseph disease/spinocerebellar ataxia type 3 (MJD/SCA3).
  
  
  METHODS
  We used a sleep questionnaire and the Epworth Sleepiness Scale to compare 53 patients with MJD/SCA3 and 106 controls.
  
  
  RESULTS
  Patients with MJD/SCA3 reported more symptoms of insomnia, restless leg syndrome and REM sleep behavior disorder as well as nocturnal cramps, snoring and nocturnal apnea. Insomnia was the most frequently reported sleep-related complaint in the MJD/SCA3 group.
  
  
  CONCLUSIONS
  Our results indicate that sleep disorders are common in patients with MJD/SCA3 and probably have a multifactorial etiology, with components of a primary sleep disorder in addition to sleep-disrupting symptoms such as nocturia and cramps.
authors.affiliation: University of Campinas, Brazil.
authors.forename: A
authors.initials: A
authors.lastname: D'Abreu
authors.forename: M
authors.initials: M
authors.lastname: França
authors.forename: L
authors.initials: L
authors.lastname: Conz
authors.forename: J H
authors.initials: JH
authors.lastname: Friedman
authors.forename: A M
authors.initials: AM
authors.lastname: Nucci
authors.forename: F
authors.initials: F
authors.lastname: Cendes
authors.forename: I
authors.initials: I
authors.lastname: Lopes-Cendes
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D007407:Interviews as Topic; D017827:Machado-Joseph Disease / Q000150:complications* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012890:Sleep; D012893:Sleep Wake Disorders / Q000150:complications*; D012913:Snoring / Q000150:complications; D011795:Surveys and Questionnaires; D055815:Young Adult