title: [Expression of MMP-2, MMP-9 and collagen type IV and their relationship in colorectal carcinomas].
abstract: OBJECTIVE
  To investigate the expression of MMP-2, MMP-9 and collagen type IV and their relationship in colorectal carcinomas.
  
  
  METHODS
  The expressions of collagen type IV, MMP-2 and MMP-9 was in normal and colorectal cancer tissues of 30 patients whose clinical stages were Dukes'B and C was detected with immunohistochennical staining. And the relationship among collagen type IV, MMP-2 and MMP-9 was analysed.
  
  
  RESULTS
  The expression of collagen type IV was significantly decreased in colorectal cancer tissues. The expression of MMP-2 and MMP-9 was not detected in normal colorectal tissues but it was significantly increased in colorectal cancer tissues. There was a negative correlation between the expression of collagen type IV and MMP-9.
  
  
  CONCLUSIONS
  The expression of collagen type IV in colorectal cancer tissues is lower than that in normal tissues. MMP-9 may play an important role in the degradation of collagen type IV in colorectal cancer.
authors.affiliation: Department of Geriatric Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.forename: Jian-tai
authors.initials: JT
authors.lastname: He
authors.forename: Jing-de
authors.initials: JD
authors.lastname: Ruan
authors.forename: Rong-bing
authors.initials: RB
authors.lastname: Wang
authors.forename: Yang-de
authors.initials: YD
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D024141:Collagen Type IV / Q000235:genetics* / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000235:genetics* / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D009367:Neoplasm Staging
chemical_list: D024141:Collagen Type IV; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9