title: Paraspinal synovial sarcoma as an unusual postradiation complication in pediatric abdominal neuroblastoma.
abstract: The development of a soft-tissue sarcoma is an infrequent but well-known long-term complication of radiotherapy. Malignant fibrous histiocytomas, extraskeletal osteosarcomas, fibrosarcomas, malignant peripheral nerve sheath tumors, and angiosarcomas are most frequently encountered. Radiation-associated synovial sarcomas are uncommon and exceedingly rare in pediatric patients. We report an unusual case of paraspinal synovial sarcoma presenting in an adolescent female 13 years after radiation therapy for her neuroblastoma.
authors.affiliation: Departments of Pediatric Hematology/Oncology, Division of Pediatrics, McMaster University, Hamilton, Ontario, Canada. mullah_ali@hotmail.com
authors.forename: Ali
authors.initials: A
authors.lastname: Mullah-Ali
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Ramsay
authors.forename: Jacqueline M
authors.initials: JM
authors.lastname: Bourgeois
authors.forename: Ian
authors.initials: I
authors.lastname: Hodson
authors.forename: Paula
authors.initials: P
authors.lastname: Macdonald
authors.forename: Mehran
authors.initials: M
authors.lastname: Midia
authors.forename: Carol
authors.initials: C
authors.lastname: Portwine
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics / Q000648:ultrastructure; D041321:Chromosomes, Human, X / Q000235:genetics / Q000648:ultrastructure; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D003606:Dacarbazine / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D007223:Infant; D008159:Lumbar Vertebrae; D008466:Mechlorethamine / Q000008:administration & dosage; D019042:Muscle Neoplasms / Q000188:drug therapy / Q000209:etiology* / Q000235:genetics / Q000532:radiotherapy; D009381:Neoplasms, Radiation-Induced / Q000188:drug therapy / Q000209:etiology* / Q000235:genetics / Q000532:radiotherapy; D016609:Neoplasms, Second Primary / Q000188:drug therapy / Q000209:etiology* / Q000235:genetics / Q000532:radiotherapy; D009447:Neuroblastoma / Q000188:drug therapy / Q000532:radiotherapy*; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D012074:Remission Induction; D012186:Retroperitoneal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D013584:Sarcoma, Synovial / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics / Q000532:radiotherapy; D013130:Spinal Stenosis / Q000209:etiology; D014178:Translocation, Genetic; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D015514:Oncogene Proteins, Fusion; C116512:SYT-SSX fusion protein; D008466:Mechlorethamine; D014750:Vincristine; D005047:Etoposide; D003606:Dacarbazine; D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin; D007069:Ifosfamide