Feedback-mediated neuronal competition for survival cues regulates innervation of a target tissue.
Proper wiring of the nervous system requires tight control of the number of nerve terminals that innervate a target tissue. Recent work by Deppmann et al., now suggests that this is achieved by feedback-mediated neuronal competition for target-derived survival cues. The authors' model is inspired by the theory for pattern formation based on self-activation and lateral inhibition, proposed by Meinhardt and Gierer more than 30 years ago.
Li
Yang
Y
Program in Neuroscience and Neurobehavior al Disorders, DUKE-National University of Singapore Graduate Medical School, Singapore.
Fivaz
Marc
M
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D019521:Body Patterning / Q000502:physiology; D002470:Cell Survival; D025461:Feedback, Physiological; D051379:Mice; D008959:Models, Neurological; D009414:Nerve Growth Factors / Q000378:metabolism; D009474:Neurons / Q000502:physiology*; D020917:Receptor, trkA / Q000378:metabolism
D009414:Nerve Growth Factors; D020917:Receptor, trkA