The functional role of some tomato products on lipid profile and liver function in adult rats.
This study was carried out to investigate the functional role of lycopene obtained from powder prepared from fresh tomato, tomato paste, and ketchup that contained equal amounts of lycopene based on levels of intake on body weight gain (BWG), feed intake, feed efficiency ratio (FER), lipid profiles, atherogenic index, and liver enzymes of hyperlipidemic rats. Forty-eight male albino rats were divided into two main groups: the first group (n = 6 rats) was kept on the basal diet as a normal control, while the second group (n = 42 rats) was fed a hyperlipidemic diet for 5 weeks to induce hyperlipidemia. The latter group was divided into seven subgroups: the first subgroup was the positive control group, while the others were supplemented with one of the tomato products at one of two levels (10 or 20 mg of lycopene/kg of diet). BWG, feed intake, and FER were calculated, and blood samples were collected to determine total lipids, total cholesterol, triglycerides, lipoprotein fractions, atherogenic index, and liver function in sera. Relative organ weights were also calculated. Results revealed that administration of various tomato products produced a significant reduction in feed intake except for the hyperlipidemic group that supplemented with the lower lycopene level from tomato paste. In addition, BWG and FER were not influenced by addition of tomato products at any level of intake. Hyperlipidemic rats supplemented with tomato powder, tomato paste, or ketchup showed significant improvement in almost all the parameters studied compared to the positive control group. Results showed that the higher lycopene level from tomato paste produced significant improvement in all lipid parameters, followed by 10 mg of lycopene/kg from tomato paste, which caused significant elevation in high-density lipoprotein cholesterol comparable to that of the negative control group. The lowest atherogenic index was achieved by addition of the lower lycopene level from tomato paste followed by the higher lycopene level from the same source. So, because of the positive effect of tomato products on the tested parameters an increase in consumption of tomato and its products in the diet is recommended. Nutrition education programs should be encouraged to inform the public of the importance of tomato and its products, especially tomato paste and ketchup, in decreasing the risk of hyperlipidemia.
Ibrahim
Hoda Salama
HS
Nutrition and Food Science Department, Faculty of Home Economics, Helwan University, Cairo, Egypt.
Ahmed
Lamiaa Ali
LA
El-din
Maha Mohamed Essam
MM
D000410:Alanine Transaminase; D000818:Animals; D001219:Aspartate Aminotransferases; D002338:Carotenoids / Q000494:pharmacology* / Q000627:therapeutic use; D004435:Eating; D006949:Hyperlipidemias / Q000188:drug therapy*; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000187:drug effects* / Q000502:physiology; D000077276:Lycopene; D018551:Solanum lycopersicum; D008297:Male; D009929:Organ Size; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley
D008055:Lipids; D010936:Plant Extracts; D002338:Carotenoids; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000077276:Lycopene