title: Parallel lines: nothing has changed?
abstract: The exponential increase in mortality rate with age is a universal feature of aging and is described mathematically by the Gompertz equation. When this equation is transformed semilogarithmically, it conforms to a straight line, the slope of which is generally used to reflect the rate of senescence. Historical and contemporary data of human and nonhuman populations show that adverse environmental conditions do not always change the slope of the log mortality rate over age. From these latter observations it is sometimes mistakenly inferred that the rate of senescence is unaffected by environmental conditions. Current biological inference emphasizes that gene action is dependent on the environment in which it is expressed. Here, we propose using the tangent line of the Gompertz equation to assess whether the rate of senescence has altered. Such an approach unmasks different rates of senescence when parameter G has remained constant, an observation that is in line with the notion that a plastic life history trait such as the rate of senescence results from the interplay of both genes and environment.
authors.affiliation: Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: Maarten P
authors.initials: MP
authors.lastname: Rozing
authors.forename: Rudi G J
authors.initials: RG
authors.lastname: Westendorp
mesh_terms: D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D004777:Environment; D006801:Humans; D008017:Life Expectancy; D008136:Longevity / Q000502:physiology*; D008875:Middle Aged; D008954:Models, Biological; D055815:Young Adult