title: Japanese-style acupuncture for endometriosis-related pelvic pain in adolescents and young women: results of a randomized sham-controlled trial.
abstract: OBJECTIVE
  To assess feasibility, and collect preliminary data for a subsequent randomized, sham-controlled trial to evaluate Japanese-style acupuncture for reducing chronic pelvic pain and improving health-related quality of life (HRQOL) in adolescents with endometriosis.
  
  
  METHODS
  Randomized, sham-controlled trial.
  
  
  METHODS
  Tertiary-referral hospital.
  
  
  METHODS
  Eighteen young women (13-22y) with laparoscopically-diagnosed endometriosis-related chronic pelvic pain.
  
  
  METHODS
  A Japanese style of acupuncture and a sham acupuncture control. Sixteen treatments were administered over 8 weeks.
  
  
  METHODS
  Protocol feasibility, recruitment numbers, pain not associated with menses or intercourse, and multiple HRQOL instruments including Endometriosis Health Profile, Pediatric Quality of Life, Perceived Stress, and Activity Limitation.
  
  
  RESULTS
  Fourteen participants (out of 18 randomized) completed the study per protocol. Participants in the active acupuncture group (n = 9) experienced an average 4.8 (SD = 2.4) point reduction on a 11 point scale (62%) in pain after 4 weeks, which differed significantly from the control group's (n = 5) average reduction of 1.4 (SD = 2.1) points (P = 0.004). Reduction in pain in the active group persisted through a 6-month assessment; however, after 4 weeks, differences between the active and control group decreased and were not statistically significant. All HRQOL measures indicated greater improvements in the active acupuncture group compared to the control; however, the majority of these trends were not statistically significant. No serious adverse events were reported.
  
  
  CONCLUSIONS
  Preliminary estimates indicate that Japanese-style acupuncture may be an effective, safe, and well-tolerated adjunct therapy for endometriosis-related pelvic pain in adolescents. A more definitive trial evaluating Japanese-style acupuncture in this population is both feasible and warranted.
authors.affiliation: Harvard Medical School, Osher Research Center, Boston, Massachusetts 02215, USA. peter_wayne@hms.harvard.edu
authors.forename: Peter M
authors.initials: PM
authors.lastname: Wayne
authors.forename: Catherine E
authors.initials: CE
authors.lastname: Kerr
authors.forename: Rosa N
authors.initials: RN
authors.lastname: Schnyer
authors.forename: Anna T R
authors.initials: AT
authors.lastname: Legedza
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Savetsky-German
authors.forename: Monica H
authors.initials: MH
authors.lastname: Shields
authors.forename: Julie E
authors.initials: JE
authors.lastname: Buring
authors.forename: Roger B
authors.initials: RB
authors.lastname: Davis
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Conboy
authors.forename: Ellen
authors.initials: E
authors.lastname: Highfield
authors.forename: Barbara
authors.initials: B
authors.lastname: Parton
authors.forename: Phaedra
authors.initials: P
authors.lastname: Thomas
authors.forename: Marc R
authors.initials: MR
authors.lastname: Laufer
mesh_terms: D015670:Acupuncture Therapy / Q000379:methods*; D000293:Adolescent; D004715:Endometriosis / Q000150:complications* / Q000628:therapy; D005260:Female; D006801:Humans; D010147:Pain Measurement / Q000379:methods; D017699:Pelvic Pain / Q000209:etiology / Q000523:psychology / Q000628:therapy*; D011788:Quality of Life; D016896:Treatment Outcome; D016387:Women's Health; D055815:Young Adult
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