Topiramate attenuates the stress-induced increase in alcohol consumption and preference in male C57BL/6J mice.
Stress increases the risk for alcohol abuse and relapse behaviors. However, there are hardly any medications to counteract stress-induced alcoholism and relapse behaviors. The present study examined the effects of topiramate (intraperitoneal injections of 10, 20, and 30 mg/kg) in its ability to attenuate alcohol consumption on exposure to restraint stress in C57BL/6J mice on a 2-choice test procedure. Mice were either restrained for 1h/day for 5 successive days or left unrestrained. Subsequently, the effects of topiramate were studied in post-restraint days. Results showed that restrained animals increased alcohol consumption and alcohol preference significantly compared to control group on day 5. On post-restraint days, topiramate reduced alcohol consumption and alcohol preference on days 2-5 compared to saline. This experiment suggests that one mechanism of topiramate in reducing alcohol consumption and alcohol preference may involve an interaction with stress.
Farook
Justin M
JM
Department of Psychology, University of Kentucky, Lexington, Kentucky 40506, USA. justinfarook@uky.edu
Lewis
Ben
B
Littleton
John M
JM
Barron
Susan
S
D000428:Alcohol Drinking / Q000188:drug therapy*; D000704:Analysis of Variance; D000818:Animals; D002755:Choice Behavior / Q000187:drug effects; D004195:Disease Models, Animal; D005518:Food Preferences / Q000187:drug effects*; D005632:Fructose / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D012149:Restraint, Physical / Q000379:methods; D013315:Stress, Psychological / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D013997:Time Factors; D000077236:Topiramate
D018696:Neuroprotective Agents; D000077236:Topiramate; D005632:Fructose