In-vitro tomography and non-destructive imaging at depth of pharmaceutical solid dosage forms.
Tomographic imaging techniques offer new prospects for a better understanding of the quality, performance and release mechanisms of pharmaceutical solid dosage forms. It is only over the last fifteen years that tomography has been applied for the in-vitro characterisation of dosage forms. This review aims to introduce the concept of tomography in a pharmaceutical context, and describes the current state-of-the-art of the four most promising techniques: X-ray computed microtomography, magnetic resonance imaging, terahertz imaging and optical coherence tomography. The basic working principles of the techniques are introduced and the current pharmaceutical applications of the technologies are discussed, together with a comparison of their specific strengths and weaknesses. Possible future developments in these fields are also discussed.
Zeitler
J Axel
JA
Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 3RA, UK. jaz22@cam.ac.uk
Gladden
Lynn F
LF
D002626:Chemistry, Pharmaceutical / Q000379:methods; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000592:standards; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods*; D055069:Terahertz Imaging / Q000379:methods*; D014054:Tomography / Q000379:methods*; D041623:Tomography, Optical Coherence / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods
D004364:Pharmaceutical Preparations