title: Mediastinal seminoma in a patient with multiple endocrine neoplasia type 1.
abstract: A patient with multiple endocrine neoplasia type 1 (MEN1) developed a mediastinal seminoma. The patient was a 46-year-old man who presented with respiratory symptoms. A diagnosis of mediastinal seminoma was pathologically confirmed and a complete remission was achieved by chemotherapy. During his hospital stay, hyperparathyroidism and multiple pancreatic tumors associated with hypergastrinemia were found. A diagnosis of MEN1 was made genetically. Although patients with MEN1 manifest a variety of neoplastic disorders, no cases of concurrent seminoma and MEN1 have previously been reported. In addition, no etiological relationship between seminoma and MEN1 has yet been reported.
authors.affiliation: The First Department of Internal Medicine, Shinshu University School of Medicine, and Shinhu University Hospital, Matsumoto. tanatuyo@shinshu-u.ac.jp
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Tanabe
authors.forename: Masanori
authors.initials: M
authors.lastname: Yasuo
authors.forename: Kenji
authors.initials: K
authors.lastname: Tsushima
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Urushihata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hanaoka
authors.forename: Tomonobu
authors.initials: T
authors.lastname: Koizumi
authors.forename: Keisaku
authors.initials: K
authors.lastname: Fujimoto
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Yamazaki
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Hirose
authors.forename: Hideaki
authors.initials: H
authors.lastname: Hamano
authors.forename: Akihiro
authors.initials: A
authors.lastname: Sakurai
authors.forename: Keishi
authors.initials: K
authors.lastname: Kubo
mesh_terms: D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D008875:Middle Aged; D018761:Multiple Endocrine Neoplasia Type 1 / Q000175:diagnosis*; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000188:drug therapy; D012074:Remission Induction; D018239:Seminoma / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology