The addition of high manganese to a copper-deficient diet further depresses copper status and growth of cattle.
A study was conducted evaluating the effect of long-term Cu deficiency, with or without high Mn, on growth, gene expression and Cu status of beef cattle. Twenty-one Angus calves were born to cows receiving one of the following treatments: (1) 10 mg supplemental Cu/kg DM (+Cu); (2) no supplemental Cu and 2 mg Mo/kg DM ( - Cu); (3) - Cu diet plus 500 mg supplemental Mn/kg DM ( - Cu+Mn). Calves were weaned at approximately 183 d of age and individually fed throughout the growing and finishing phases. Plasma Cu was lower (P < 0.01) in - Cu calves compared with +Cu calves while high dietary Mn further depressed (P < 0.01) plasma Cu in - Cu+Mn calves v. - Cu calves. Liver Cu concentrations in +Cu calves were greater (P < 0.01) than in - Cu calves, with no differences between - Cu and - Cu+Mn calves. The daily body-weight gain of +Cu calves was greater (P < 0.01) than - Cu calves during the period from birth to weaning, but did not differ during the growing phase. - Cu+Mn calves gained less (P < 0.05) than - Cu calves during the growing phase. DM intake was lower (P < 0.01) in - Cu+Mn calves v. - Cu calves, and did not differ among +Cu and - Cu calves. The relative gene expression of cytochrome c oxidase in the liver was lower (P < 0.05) in - Cu calves compared with +Cu or - Cu+Mn calves. In conclusion, feeding a Cu - deficient diet in combination with high Mn negatively affected the growth and Cu status of beef cattle.
Hansen
Stephanie L
SL
Department of Animal Science, North Carolina State University, Raleigh, NC 27695, USA.
Ashwell
Melissa S
MS
Legleiter
Leon R
LR
Fry
Robert S
RS
Lloyd
Karen E
KE
Spears
Jerry W
JW
D000821:Animal Feed; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002417:Cattle / Q000254:growth & development / Q000378:metabolism*; D003300:Copper / Q000172:deficiency*; D051545:Cyclooxygenase 1 / Q000235:genetics; D003864:Depression, Chemical; D005260:Female; D015870:Gene Expression / Q000187:drug effects; D008099:Liver / Q000378:metabolism; D008297:Male; D008345:Manganese / Q000008:administration & dosage* / Q000032:analysis; D009752:Nutritional Status; D011897:Random Allocation; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D013482:Superoxide Dismutase / Q000235:genetics; D000072105:Superoxide Dismutase-1; D013997:Time Factors
D008345:Manganese; D003300:Copper; D051545:Cyclooxygenase 1; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1