title: Patency and Agile capsules.
abstract: Small bowel strictures can be missed by current diagnostic methods. The Patency capsule is a new non-endoscopic dissolvable capsule which has as an objective of checking the patency of digestive tract, in a non-invasive manner. The available clinical trials have demonstrated that the Patency capsule is a good tool for assessment of the functional patency of the small bowel, and it allows identification of those patients who can safely undergo a capsule endoscopy, despite clinical and radiographic evidence of small-bowel obstruction. Some cases of intestinal occlusion have been reported with the Patency capsule, four of them needed surgery. So, a new capsule with two timer plugs (Agile capsule) has been recently developed in order to minimize the risk of occlusion. This new device stars its dissolution process earlier (30 h after ingestion) and its two timer plugs have been designed to begin the disintegration even when the device is blocked in a tight stricture.
authors.affiliation: Gastroenterology Service, "Virgen Macarena" University Hospital, Avda. Dr. Fedriani, Seville 41071, Spain. acaunedoa@meditex.es
authors.forename: Angel
authors.initials: A
authors.lastname: Caunedo-Alvarez
authors.forename: Javier
authors.initials: J
authors.lastname: Romero-Vazquez
authors.forename: Juan-M
authors.initials: JM
authors.lastname: Herrerias-Gutierrez
mesh_terms: D053705:Capsule Endoscopes / Q000009:adverse effects; D002986:Clinical Trials as Topic; D003251:Constriction, Pathologic; D006801:Humans; D007415:Intestinal Obstruction / Q000175:diagnosis; D007421:Intestine, Small / Q000473:pathology
references.citation: Endoscopy. 2005 Sep;37(9):801-7
references.pmid: 16116529
references.citation: Endoscopy. 2005 Oct;37(10):1065-7
references.pmid: 16189792
references.citation: Gastrointest Endosc. 2004 Jun;59(7):926-7
references.pmid: 15173819
references.citation: Gastrointest Endosc. 2004 Nov;60(5):822-7
references.pmid: 15557969
references.citation: Gut. 2004 Mar;53(3):472
references.pmid: 14960546
references.citation: Rev Esp Enferm Dig. 2004 Jan;96(1):10-21
references.pmid: 14971993
references.citation: Gut. 2003 Mar;52(3):390-2
references.pmid: 12584221
references.citation: Am J Gastroenterol. 2004 Nov;99(11):2171-7
references.pmid: 15554999
references.citation: Gastrointest Endosc. 2004 Mar;59(3):461
references.pmid: 14997161
references.citation: Endoscopy. 2005 Sep;37(9):793-800
references.pmid: 16116528
references.citation: Am J Gastroenterol. 2006 Oct;101(10):2218-22
references.pmid: 16848804
references.citation: Gastrointest Endosc. 2003 Mar;57(3):427-8
references.pmid: 12612537
references.citation: Nature. 2000 May 25;405(6785):417
references.pmid: 10839527
references.citation: Clin Gastroenterol Hepatol. 2004 Jan;2(1):31-40
references.pmid: 15017630
references.citation: Clin Gastroenterol Hepatol. 2005 Feb;3(2):133-41
references.pmid: 15704047
references.citation: Dig Liver Dis. 2006 May;38(5):326-30
references.pmid: 16527556
references.citation: Endoscopy. 2003 Aug;35(8):713
references.pmid: 12929075
references.citation: Endoscopy. 2003 Jul;35(7):564-8
references.pmid: 12822090
references.citation: Gastrointest Endosc. 2005 Nov;62(5):712-6; quiz 752, 754
references.pmid: 16246685
references.citation: Eur J Gastroenterol Hepatol. 2003 Apr;15(4):363-7
references.pmid: 12655255
references.citation: Gastrointest Endosc. 2006 Aug;64(2):283-7
references.pmid: 16860090
references.citation: Endoscopy. 2005 Feb;37(2):174-7
references.pmid: 15692935
references.citation: J Clin Gastroenterol. 2006 Sep;40(8):688-91
references.pmid: 16940879
references.citation: J Clin Gastroenterol. 2007 Jul;41(6):576-82
references.pmid: 17577114
references.citation: Gastroenterology. 2004 Mar;126(3):643-53
references.pmid: 14988816
references.citation: Endoscopy. 2005 Sep;37(9):808-15
references.pmid: 16116530
references.citation: J Clin Gastroenterol. 2003 Sep;37(3):270-1
references.pmid: 12960730
references.citation: Gastrointest Endosc. 2008 May;67(6):902-9
references.pmid: 18355824