title: A complex t(1;22;11)(q44;q13;q23) translocation causing MLL-p300 fusion gene in therapy-related acute myeloid leukemia.
abstract: The p300 protein shows a striking homology with cyclic-AMP-response-element-binding-protein binding protein (CBP) and both proteins form a family of DNA-binding transcriptional coactivators/histone acetyltransferases. The authors, herein, report a therapy-related acute myeloid leukemia with MLL-p300 fusion gene. Spectral karyotyping clarified that chromosome 11 is involved in complex t(1;22;11)(q44;q13;q23), and is fused to the chromosome 22, and direct sequencing revealed the fusion of exon 8 of MLL and exon 15 of p300 in this case. This is only the second reported case of leukemia with an MLL-p300 fusion gene, and the other case with MLL-p300 was also a therapy-related leukemia. Considering that the MLL-CBP fusion gene is also found almost exclusively in therapy-related leukemia, the association of MLL-p300 and MLL-CBP with therapy-related leukemia rather than de novo leukemia is thereby suggested.
authors.affiliation: Department of Laboratory Medicine, Kyorin University, Mitaka, Tokyo, Japan. onishi@ks.kyorin-u.ac.jp
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ohnishi
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Taki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshino
authors.forename: Junko
authors.initials: J
authors.lastname: Takita
authors.forename: Kohmei
authors.initials: K
authors.lastname: Ida
authors.forename: Masami
authors.initials: M
authors.lastname: Ishii
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nishida
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Masafumi
authors.initials: M
authors.lastname: Taniwaki
authors.forename: Fumio
authors.initials: F
authors.lastname: Bessho
authors.forename: Takashi
authors.initials: T
authors.lastname: Watanabe
mesh_terms: D002675:Child, Preschool; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005260:Female; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced* / Q000235:genetics*; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics*; D016609:Neoplasms, Second Primary / Q000139:chemically induced* / Q000235:genetics* / Q000473:pathology; D009447:Neuroblastoma / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D014178:Translocation, Genetic; D050880:p300-CBP Transcription Factors / Q000235:genetics*
chemical_list: C497422:KMT2A protein, human; D015514:Oncogene Proteins, Fusion; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase; D050880:p300-CBP Transcription Factors