Hydration of drug-DNA complexes: greater water uptake for adriamycin compared to daunomycin.
Water is an integral part of DNA, and the conserved water molecules at the binding sites can modulate drug binding to DNA or protein. We report here that anthracycline antitumor antibiotics, adriamycin (AM) and daunomycin (DM), binding to DNA is accompanied by different hydration changes, with AM binding resulting in the uptake of about twice as many water molecules as DM. These results indicate that water is playing an important role in drug binding to DNA.
Yu
Haijia
H
Division of Biological Inorganic Chemistry, Key Laboratory of Rare Earth Chemistry and Physics, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin 130022, China.
Ren
Jinsong
J
Chaires
Jonathan B
JB
Qu
Xiaogang
X
D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D001665:Binding Sites; D004247:DNA / Q000737:chemistry*; D003630:Daunorubicin / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry*; D015394:Molecular Structure; D014867:Water / Q000737:chemistry*
D000903:Antibiotics, Antineoplastic; D014867:Water; D004317:Doxorubicin; D004247:DNA; D003630:Daunorubicin
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