Is the blood B-cell subset profile diagnostic for Sjogren syndrome?
OBJECTIVE
To evaluate the relevance of the blood B-cell subset profile for the diagnosis of Sjögren syndrome.


METHODS
The distribution of mature blood B cells from Bm1 through Bm5 was determined in 161 patients, of whom 25 fulfilled the American-European Consensus Group criteria for primary SS (pSS), and 136 served as disease controls.


RESULTS
The percentage of Bm2 and Bm2' cells was increased in the patients with pSS compared with 54 patients with rheumatoid arthritis (RA) and 18 with systemic lupus erythematosus (SLE) (p<0.001 for the two comparisons). In contrast, those of early Bm5 (eBm5) and Bm5 were decreased in patients with pSS, compared with patients with RA and with SLE (p<0.001 for the two comparisons). The receiver operating characteristic curves allowed for an optimising cut-off value of Bm2+Bm2' cells at 71.1% for 88.0% sensitivity and 83.1% specificity, that of eBm5+Bm5 cells at < or =13.5% for 84.0% sensitivity and 83.1% specificity, and, consequently, that of Bm2+Bm2'/eBm5+Bm5 at > or =5 for 88.0% sensitivity and 84.6% specificity.


CONCLUSIONS
Given its presentation as a signature for pSS, relative to RA and SLE, such a distribution of B-cell subsets might provide a useful diagnostic tool.
Binard
A
A
EA Immunologie et Pathologie, Université Européenne de Bretagne, et Université de Bretagne Occidentale, Brest, et Centre Hospitalier Universitaire de Brest, Brest F29609, France.
Le Pottier
L
L
Devauchelle-Pensec
V
V
Saraux
A
A
Youinou
P
P
Pers
J-O
JO
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000276:immunology; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D003937:Diagnosis, Differential; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012859:Sjogren's Syndrome / Q000175:diagnosis* / Q000276:immunology
D015415:Biomarkers
Arthritis Rheum. 1997 Feb;40(2):318-31
9041944
Arthritis Rheum. 2007 May;56(5):1371-7
17469093
Arthritis Res. 2002;4(6):360-71
12453312
Arthritis Rheum. 2002 Aug;46(8):2160-71
12209521
Arthritis Rheum. 2007 Mar 15;57(2):310-7
17330280
Ann Rheum Dis. 2002 Jun;61(6):482-4
12006316
J Immunol. 2001 Oct 1;167(7):3610-8
11564773
Arthritis Rheum. 1988 Mar;31(3):315-24
3358796
Arthritis Rheum. 1997 Sep;40(9):1725
9324032
Ann Rheum Dis. 2002 Jun;61(6):554-8
12006334
J Exp Med. 1994 Jul 1;180(1):329-39
8006591
Arthritis Rheum. 2002 Mar;46(3):741-7
11920410
Arthritis Rheum. 2007 May;56(5):1464-77
17469105
Clin Immunol Immunopathol. 1994 Aug;72(2):162-5
8050187
Arthritis Rheum. 1993 Mar;36(3):340-7
8452579
Clin Exp Rheumatol. 2007 Jan-Feb;25(1):1-4
17417982
Front Biosci. 2007 Jan 01;12:2159-70
17127453
Arthritis Rheum. 2006 Jul;54(7):2280-8
16802367
Arthritis Rheum. 2005 Sep;52(9):2740-50
16142737
Arthritis Rheum. 2007 Oct 15;57(7):1112-5
17907226
Arthritis Rheum. 2006 Jan;54(1):115-26
16385503
Ann Rheum Dis. 2003 Jan;62(1):94-5; author reply 95
12480687