title: Comparative risk of impaired glucose metabolism associated with cyclosporine versus tacrolimus in the late posttransplant period.
abstract: New onset diabetes after transplantation (NODAT) and impaired fasting glucose (IFG) are common in kidney transplant recipients (KTRs). Calcinuerin inhibitor (CNI) therapy is a causal risk factor. NODAT is associated with increased mortality and diminished graft survival. We studied the incidence of NODAT and IFG in KTRs before and after a medically indicated switch of CNI therapy from cyclosporine (CsA) to tacrolimus (Tac). The study population consisted of 704 nondiabetic KTRs. Of them, 171 underwent conversion from CsA to Tac (group I) and 533 remained on the CsA since transplantation (Group II). Time-dependent Cox regression and generalized estimating equations were used to account for sequential CNI exposure. NODAT and IFG occurred in 15.2% and 22.1% of group I subjects and 15.6% and 25.8% of group II subjects, respectively (p = 0.90 for NODAT and p = 0.38 for IFG). Accounting for equal follow-up time since conversion from CsA to Tac, the adjusted 5-year NODAT-free survival was 87.4% and 91.4% in group I and group II, respectively (p = 0.90). In conclusion, conversion to Tac, compared to continuous exposure to CsA, carries quantitatively similar risk of impaired glucose metabolism in KTRs in the late posttransplant period.
authors.affiliation: Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, MI, USA. fluan@med.umich.edu
authors.forename: F L
authors.initials: FL
authors.lastname: Luan
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.forename: D E
authors.initials: DE
authors.lastname: Schaubel
authors.forename: C D
authors.initials: CD
authors.lastname: Miles
authors.forename: D
authors.initials: D
authors.lastname: Cibrik
authors.forename: S
authors.initials: S
authors.lastname: Norman
authors.forename: A O
authors.initials: AO
authors.lastname: Ojo
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D015331:Cohort Studies; D016572:Cyclosporine / Q000276:immunology*; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000209:etiology; D005215:Fasting; D005260:Female; D005500:Follow-Up Studies; D005947:Glucose / Q000378:metabolism*; D006085:Graft Survival; D017408:Guidelines as Topic; D006801:Humans; D007166:Immunosuppressive Agents / Q000276:immunology*; D015994:Incidence; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D016559:Tacrolimus / Q000276:immunology*; D013997:Time Factors; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology
chemical_list: D001786:Blood Glucose; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D005947:Glucose; D016559:Tacrolimus