title: Effects of the partial gastrectomy associated to anterior truncal vagotomy in the metabolism of the iron in rats.
abstract: OBJECTIVE
  To evaluate the effects of the partial gastrectomy associated to anterior truncal vagotomy in the absorption and metabolism of iron.
  
  
  METHODS
  Eighteen adults male Wistar rats were submitted to the partial gastrectomy associated to anterior truncal vagotomy (eight animals) and the sham operation (10 animals, control group). The diet consumption and the weight gains of the animals were monitored three times during the week. The animals received supplements of vitamin B12, for the prevention of the megaloblastic anemia, and a formulated experimental diet orally and denominated AIN-93M by 8 weeks. The fecal iron, apparent absorption of the iron, haematocrit, haemoglobin and serum iron were measured after 60 days.
  
  
  RESULTS
  The animals undergoing sham operation presented larger statistical averages (p<0.05) for the diet consumption, weight gains, apparent absorption of iron, haematocrit, haemoglobin and serum iron compared to the gastrectomized group. However, the excretion of iron in feces was larger in the gastrectomized group (+14.3%) (p<0.05) when compared to the control group.
  
  
  CONCLUSIONS
  Partial gastrectomy associated to anterior truncal vagotomy showed to be a good experimental model the study of iron metabolism, decreasing the haematocrit, the haemoglobin and the iron absorption, consequently causing anemia.
authors.affiliation: FEA, DEPAN, UNICAMP, Sao Paulo, Brazil.
authors.forename: Elisvânia Freitas
authors.initials: EF
authors.lastname: Dos Santos
authors.forename: Kathia Hitomi
authors.initials: KH
authors.lastname: Tsuboi
authors.forename: Beatriz Frolini
authors.initials: BF
authors.lastname: Palu
authors.forename: Marina Rachel
authors.initials: MR
authors.lastname: Araújo
authors.forename: Nelson Adami
authors.initials: NA
authors.lastname: Andreollo
authors.forename: Celio Kenji
authors.initials: CK
authors.lastname: Miyasaka
mesh_terms: D000740:Anemia / Q000209:etiology* / Q000378:metabolism; D000818:Animals; D005243:Feces / Q000737:chemistry; D005743:Gastrectomy / Q000379:methods*; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D007408:Intestinal Absorption; D007501:Iron / Q000032:analysis / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013270:Stomach / Q000294:innervation / Q000601:surgery*; D015167:Vagotomy, Truncal
chemical_list: D006454:Hemoglobins; D007501:Iron