Reverse engineering models of cell cycle regulation.
From general considerations of the basic physiological properties of the cell division cycle, we deduce what the dynamical properties of the underlying molecular control system must be. Then, taking a few hints from the biochemistry of cyclin-dependent kinases (the master regulators of the eukaryotic cell cycle), we guess what molecular mechanisms must be operating to produce the desired dynamical properties of the control system.
Csikász-Nagy
Attila
A
Materials Structure and Modeling Research Group of the Hungarian Academy of Sciences, Budapest, Hungary. csikasz@mail.bme.hu
Novák
Béla
B
Tyson
John J
JJ
D001683:Biological Clocks; D001698:Biomedical Engineering; D002453:Cell Cycle / Q000502:physiology*; D053858:Metabolic Networks and Pathways; D008954:Models, Biological; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000502:physiology