title: Synthesis and activity of 1-(3-amino-1-phenylpropyl)indolin-2-ones: a new class of selective norepinephrine reuptake inhibitors.
abstract: Norepinephrine and serotonin play an important role in a wide variety of biological processes and are implicated in a number of neurological disorders. A novel class of 1-(3-amino-1-phenylpropyl)indolin-2-ones was designed and synthesized that displays potent norepinephrine reuptake inhibition while maintaining high selectivity (>100-fold) against the human serotonin and dopamine transporters.
authors.affiliation: Chemical and Screening Sciences, Wyeth Research, 500 Arcola Road, S2227A, Collegeville, PA 19426, USA. mccomac@wyeth.com
authors.forename: Casey C
authors.initials: CC
authors.lastname: McComas
authors.forename: An T
authors.initials: AT
authors.lastname: Vu
authors.forename: Paige E
authors.initials: PE
authors.lastname: Mahaney
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Cohn
authors.forename: Andrew
authors.initials: A
authors.lastname: Fensome
authors.forename: Michael A
authors.initials: MA
authors.lastname: Marella
authors.forename: Lisa
authors.initials: L
authors.lastname: Nogle
authors.forename: Eugene J
authors.initials: EJ
authors.lastname: Trybulski
authors.forename: Fei
authors.initials: F
authors.lastname: Ye
authors.forename: Puwen
authors.initials: P
authors.lastname: Zhang
authors.forename: Peter
authors.initials: P
authors.lastname: Alfinito
authors.forename: Jenifer
authors.initials: J
authors.lastname: Bray
authors.forename: Grace
authors.initials: G
authors.lastname: Johnston
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Koury
authors.forename: Darlene C
authors.initials: DC
authors.lastname: Deecher
mesh_terms: D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D014179:Neurotransmitter Uptake Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009638:Norepinephrine / Q000037:antagonists & inhibitors*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D007211:Indoles; D014179:Neurotransmitter Uptake Inhibitors; C456900:indolin-2-one; D009638:Norepinephrine