Severe eosinophilia as a manifestation of acute graft-versus-host disease.
Significant peripheral eosinophilia in association with acute graft-versus-host disease (GVHD) is rare. Here we report a case of eosinophilia in a 30-year-old woman with relapsed acute myelogenous leukemia after an allogeneic bone marrow transplant who was treated with donor lymphocyte infusion (DLI). A month after the DLI, she developed a pruritic erythematous rash, hepatic enzyme elevations and eosinophilia that peaked at 23,300 cells/mm(3). A diagnosis of acute GVHD was made and the patient was treated with corticosteroids with a resolution of all of the aforementioned findings. The authors suggest that eosinophilia in a bone marrow transplantation patient should raise suspicion of GVHD.
Paralkar
Vikram R
VR
Department of Internal Medicine, Temple University Hospital, Philadelphia, PA 19140, USA. vikram.paralkar@tuhs.temple.edu
Goradia
Ami
A
Luger
Selina M
SM
Loren
Alison W
AW
D000328:Adult; D016026:Bone Marrow Transplantation; D004802:Eosinophilia / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006086:Graft vs Host Disease / Q000175:diagnosis* / Q000188:drug therapy; D020544:Graft vs Leukemia Effect; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000473:pathology / Q000628:therapy*; D017710:Lymphocyte Transfusion; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis; D016879:Salvage Therapy
D005938:Glucocorticoids