title: Cytogenetic abnormality 46,XX,add(21)(q11.2) in a patient with follicular dendritic cell sarcoma.
abstract: The case of a patient with follicular dendritic cell (FDC) sarcoma with chromosomal aberration add(21)(q11.2) is described. Cytogenetic studies showed the karyotype 46,XX,add(21)(q11.2)[3]/46,XX[17], although the encoded protein involved was not clarified. The abnormal pattern was quite simple, and different from a previous report. The clinical course of the FDC sarcoma in this case has been indolent, as for most FDC sarcoma patients. Although this patient suffered from breast carcinoma 6 years after the onset of FDC sarcoma, the carcinoma showed different histological and phenotypic profiles.
authors.affiliation: Tohoku University School of Medicine, Sendai, Japan.
authors.forename: Naomi
authors.initials: N
authors.lastname: Suzuki
authors.forename: Hiroki
authors.initials: H
authors.lastname: Katsusihma
authors.forename: Kengo
authors.initials: K
authors.lastname: Takeuchi
authors.forename: Shigeo
authors.initials: S
authors.lastname: Nakamura
authors.forename: Kenichi
authors.initials: K
authors.lastname: Ishizawa
authors.forename: Seiichi
authors.initials: S
authors.lastname: Ishii
authors.forename: Takuya
authors.initials: T
authors.lastname: Moriya
authors.forename: John F
authors.initials: JF
authors.lastname: DeCoteau
authors.forename: Ikuo
authors.initials: I
authors.lastname: Miura
authors.forename: Ryo
authors.initials: R
authors.lastname: Ichinohasama
mesh_terms: D002293:Adenocarcinoma, Scirrhous / Q000235:genetics; D001365:Axilla; D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000235:genetics; D018270:Carcinoma, Ductal, Breast / Q000235:genetics; D002869:Chromosome Aberrations; D002891:Chromosomes, Human, Pair 21; D054740:Dendritic Cell Sarcoma, Follicular / Q000235:genetics* / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D008198:Lymph Nodes / Q000473:pathology; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D009378:Neoplasms, Multiple Primary / Q000235:genetics*; D017464:Receptors, Complement 3d / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D017464:Receptors, Complement 3d