Pharmacologic modulation of ACE2 expression.
Angiotensin-converting enzyme 2 (ACE2) is an enzymatically active homologue of angiotensin-converting enzyme that degrades angiotensin I, angiotensin II, and other peptides. Recent studies have shown that under pathologic conditions, ACE2 expression in the kidney is altered. In this review, we briefly summarize recent studies dealing with pharmacologic interventions that modulate ACE2 expression. ACE2 amplification may have a potential therapeutic role for kidney disease and hypertension.
Soler
María José
MJ
Division of Nephrology and Hypertension, Department of Medicine, Feinberg School of Medicine, Northwestern University, 320 East Superior, Chicago, IL 60611, USA.
Barrios
Clara
C
Oliva
Raymond
R
Batlle
Daniel
D
D000803:Angiotensin I / Q000096:biosynthesis* / Q000187:drug effects; D000804:Angiotensin II / Q000096:biosynthesis* / Q000187:drug effects; D047228:Angiotensin II Type 1 Receptor Blockers / Q000627:therapeutic use; D000085962:Angiotensin-Converting Enzyme 2; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use; D018450:Disease Progression; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D007703:Peptidyl-Dipeptidase A / Q000096:biosynthesis* / Q000187:drug effects*; D044140:Receptor, Angiotensin, Type 1 / Q000187:drug effects; D012084:Renin-Angiotensin System / Q000187:drug effects
D047228:Angiotensin II Type 1 Receptor Blockers; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D044140:Receptor, Angiotensin, Type 1; D000804:Angiotensin II; D000803:Angiotensin I; D007703:Peptidyl-Dipeptidase A; C000705307:ACE2 protein, human; D000085962:Angiotensin-Converting Enzyme 2
Diabetes. 2008 Apr;57(4):1018-25
18235039
Circ Res. 2006 Mar 3;98(4):463-71
16514079
Am J Physiol Regul Integr Comp Physiol. 2007 Jan;292(1):R373-81
16946085
Hypertension. 2008 May;51(5):1312-7
18391097
Hypertension. 2004 May;43(5):993-1002
15007034
Am J Physiol Cell Physiol. 2006 Feb;290(2):C420-6
16176966
Kidney Int. 2006 Jul;70(1):34-41
16710353
Hypertension. 2003 Oct;42(4):749-53
12874086
Hypertension. 2004 May;43(5):1120-5
15078862
Circ Res. 2005 Oct 28;97(9):946-53
16179584
Curr Hypertens Rep. 2008 Feb;10(1):70-7
18367030
Am J Hypertens. 2007 Oct;20(10):1119-24
17903697
Am J Physiol Renal Physiol. 2006 Dec;291(6):F1308-14
16788142
Life Sci. 2006 Apr 4;78(19):2166-71
16303146
J Am Soc Nephrol. 2006 Nov;17(11):3067-75
17021266
Kidney Int. 2007 Sep;72(5):614-23
17579661
Med Hypotheses. 2005;64(3):476-8
15617852
Transl Res. 2008 Apr;151(4):208-16
18355768
Diabetes. 2006 Jul;55(7):2132-9
16804085
Nature. 2002 Jun 20;417(6891):822-8
12075344
Am J Hypertens. 2008 May;21(5):576-81
18437150
Hypertens Res. 2006 Nov;29(11):865-74
17345786
Cardiovasc Res. 2007 Jul 1;75(1):29-39
17499227
J Pathol. 2004 Jun;203(2):631-7
15141377
Virology. 2006 Sep 30;353(2):474-81
16860835
Exp Physiol. 2008 May;93(5):564-9
18192339
Am J Physiol Heart Circ Physiol. 2005 Sep;289(3):H1013-9
15833808
Exp Physiol. 2008 May;93(5):648-57
18296494
Exp Physiol. 2008 May;93(5):549-56
18223023
Circ Res. 2000 Sep 1;87(5):E1-9
10969042
Hypertension. 2004 Dec;44(6):907-12
15477383
Nature. 2005 Jul 7;436(7047):112-6
16001071
Kidney Int. 2005 Nov;68(5):2189-96
16221218
Gut. 2005 Dec;54(12):1790-6
16166274
Am J Pathol. 2008 May;172(5):1174-83
18403595
Hypertension. 2006 Oct;48(4):572-8
16908757
Am J Physiol Renal Physiol. 2007 Jul;293(1):F245-54
17409278
J Biol Chem. 2000 Oct 27;275(43):33238-43
10924499
Placenta. 2006 Feb-Mar;27(2-3):200-7
16338465
Curr Opin Nephrol Hypertens. 2008 May;17(3):250-7
18408475
Hypertension. 2006 Apr;47(4):718-26
16505206
Am J Pathol. 2007 Aug;171(2):438-51
17600118
Am J Physiol Heart Circ Physiol. 2006 Nov;291(5):H2166-72
16766648