title: Application of ion exchange resin in floating drug delivery system.
abstract: The purpose of this study was to explore the application of low-density ion exchange resin (IER) Tulsion(R) 344, for floating drug delivery system (FDDS), and study the effect of its particle size on rate of complexation, water uptake, drug release, and in situ complex formation. Batch method was used for the preparation of complexes, which were characterized by physical methods. Tablet containing resin with high degree of crosslinking showed buoyancy lag time (BLT) of 5-8 min. Decreasing the particle size of resin showed decrease in water uptake and drug release, with no significant effect on the rate of complexation and in situ complex formation for both preformed complexes (PCs) and physical mixtures (PMs). Thus, low-density and high degree of crosslinking of resin and water uptake may be the governing factor for controlling the initial release of tablet containing PMs but not in situ complex formation. However, further sustained release may be due to in situ complex formation.
authors.affiliation: Department of Pharmaceutics, Bharati Vidyapeeth Deemed University, Poona College of Pharmacy, Erandwane, Pune, Maharashtra, India. abhiupadhye_a@rediffmail.com
authors.forename: Abhijeet A
authors.initials: AA
authors.lastname: Upadhye
authors.forename: Anshuman A
authors.initials: AA
authors.lastname: Ambike
authors.forename: Kakasaheb R
authors.initials: KR
authors.lastname: Mahadik
authors.forename: Anant
authors.initials: A
authors.lastname: Paradkar
mesh_terms: D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D007475:Ion Exchange Resins / Q000737:chemistry*; D010316:Particle Size; D012995:Solubility; D013997:Time Factors; D014961:X-Ray Diffraction
chemical_list: D003692:Delayed-Action Preparations; D007475:Ion Exchange Resins