Synthesis and biological activity of anticoccidial agents: 5,6-diarylimidazo[2,1-b][1,3]thiazoles.
Novel 5,6-diarylimidazo[2,1-b][1,3]thiazoles bearing an amine substituent at the imidazothiazole 2-position have been synthesized and evaluated as anticoccidial agents in both in vitro and in vivo assays. Both subnanomolar in vitro activity and broad spectrum in vivo potency were detected for several compounds, particularly compound 10.
Scribner
Andrew
A
SCYNEXIS, Inc., Discovery Chemistry, PO Box 12878, Research Triangle Park, NC 27709-2878, USA. andrew.scribner@scynexis.com
Meitz
Susan
S
Fisher
Michael
M
Wyvratt
Matthew
M
Leavitt
Penny
P
Liberator
Paul
P
Gurnett
Anne
A
Brown
Chris
C
Mathew
John
J
Thompson
Donald
D
Schmatz
Dennis
D
Biftu
Tesfaye
T
D000818:Animals; D003049:Coccidiostats / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D020650:Combinatorial Chemistry Techniques; D017869:Cyclic GMP-Dependent Protein Kinases / Q000037:antagonists & inhibitors; D004539:Eimeria / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D003049:Coccidiostats; D007093:Imidazoles; D047428:Protein Kinase Inhibitors; D013844:Thiazoles; D017869:Cyclic GMP-Dependent Protein Kinases