Salvileucalin B, a novel diterpenoid with an unprecedented rearranged neoclerodane skeleton from Salvia leucantha Cav.
Salvileucalin B (2), having an unprecedented rearranged neoclerodane skeleton, was isolated from the aerial parts of Salvia leucantha Cav. (Labiatae) along with salvileucalin A (1). The absolute structures were elucidated by spectroscopic analysis, X-ray crystallographic analysis, and vibrational circular dichroism. Compound 2 represents a novel neoclerodane, characterized by a tricyclo[3.2.1.0 (2,7)]octane substructure incorporating the exocyclic C-20 methylene of 1. This molecule exerted cytotoxic activity against A549 and HT-29 cells with IC50 values of 5.23 and 1.88 microg/mL, respectively.
Aoyagi
Yutaka
Y
School of Pharmacy, Tokyo University of Pharmacy & Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Yamazaki
Akira
A
Nakatsugawa
Chihiro
C
Fukaya
Haruhiko
H
Takeya
Koichi
K
Kawauchi
Susumu
S
Izumi
Hiroshi
H
D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D045785:Diterpenes, Clerodane; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D027544:Salvia / Q000737:chemistry*
D004224:Diterpenes; D045785:Diterpenes, Clerodane; C468586:neoclerodane; C533291:salvileucalin B