One-pot synthesis of antiviral acyclovir and other nucleosides derivatives using doped natural phosphate as lewis acid catalyst.
Natural phosphate doped with iodine or potassium iodide is an active catalyst for the one-pot synthesis of acyclonucleosides. To demonstrate the utility of the new catalyst system, the highly important antiviral drug acyclovir was directly and regioselectively obtained from NAcG with no byproducts.
Lazrek
Hassan B
HB
Faculty of Science Semlalia, Unité de Chimie Biomoléculaire et Médicinale, Marrakech, Morocco. hblazrek50@gmail.com
Baddi
Laila
L
Smietana
Michael
M
Vasseur
Jean-Jacques
JJ
Sebti
Said
S
Zahouily
Mohamed
M
D000212:Acyclovir / Q000138:chemical synthesis*; D000998:Antiviral Agents / Q000138:chemical synthesis*; D002384:Catalysis; D007455:Iodine / Q000737:chemistry; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis*; D010710:Phosphates / Q000737:chemistry*
D000998:Antiviral Agents; D009705:Nucleosides; D010710:Phosphates; D007455:Iodine; D000212:Acyclovir