title: Correlation of Fourier domain optical coherence tomography retinal nerve fiber layer maps with visual fields in nonarteritic ischemic optic neuropathy.
abstract: To correlate peripapillary retinal nerve fiber layer (NFL) loss and visual field defects in nonarteritic ischemic optic neuropathy (NAION).
  
  
  
  Patients with NAION and control subjects were enrolled in a case-control study. Participants were scanned with a Fourier domain optical coherence tomography (OCT) system. Peripapillary NFL thickness was averaged in hemispheric, quadrant, and octant divisions. Standard achromatic static perimetry was used to assess visual fields.
  
  
  
  The reproducibility of peripapillary NFL parameters was excellent in both the healthy and NAION groups. Eyes in the NAION group showed a significant decrease of peripapillary NFL thickness in terms of the overall average, all quadrant averages, and all octants. There were statistically significant correlations between the peripapillary NFL and visual fields in terms of both overall averages and superior-inferior differences.
  
  
  
  In NAION, the visual field and peripapillary NFL losses are correlated in both severity and location. Fourier domain OCT provides reproducible measurement of the peripapillary NFL and may be useful in the assessment of NAION.
authors.affiliation: Department of Ophthalmology, University of Southern California, Los Angeles, California, USA.
authors.forename: Tarek
authors.initials: T
authors.lastname: Alasil
authors.forename: Ou
authors.initials: O
authors.lastname: Tan
authors.forename: Ake Tzu-hui
authors.initials: AT
authors.lastname: Lu
authors.forename: David
authors.initials: D
authors.lastname: Huang
authors.forename: Alfredo A
authors.initials: AA
authors.lastname: Sadun
mesh_terms: D005260:Female; D005583:Fourier Analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D018917:Optic Neuropathy, Ischemic / Q000473:pathology* / Q000503:physiopathology; D015203:Reproducibility of Results; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*; D014794:Visual Fields
references.citation: Arch Ophthalmol. 2006 Aug;124(8):1111-7
references.pmid: 16908813
references.citation: J Neuroophthalmol. 2007 Sep;27(3):176-9
references.pmid: 17895816
references.citation: J Opt Soc Am A Opt Image Sci Vis. 2007 May;24(5):1426-30
references.pmid: 17429489
references.citation: Ophthalmology. 2008 Feb;115(2):298-305.e2
references.pmid: 17698200
references.citation: Ophthalmology. 2008 May;115(5):904-10
references.pmid: 17870170
references.citation: Clin Neurosci. 1997;4(5):251-63
references.pmid: 9292252
references.citation: Invest Ophthalmol Vis Sci. 2007 Feb;48(2):763-73
references.pmid: 17251476
references.citation: Invest Ophthalmol Vis Sci. 2007 Aug;48(8):3662-8
references.pmid: 17652736
references.citation: BMC Ophthalmol. 2006 Nov 20;6:34
references.pmid: 17116264
references.citation: Am J Ophthalmol. 2005 Jan;139(1):44-55
references.pmid: 15652827
references.citation: Biometrics. 2000 Jun;56(2):645-6
references.pmid: 10877330
references.citation: J Neuroophthalmol. 2003 Jun;23(2):157-63
references.pmid: 12782932
references.citation: Nat Med. 2001 Apr;7(4):502-7
references.pmid: 11283681
references.citation: Bull Soc Belge Ophtalmol. 2006;(302):123-32
references.pmid: 17265794