Drug-related hepatotoxicity and hepatic failure following combined androgen blockade.
Androgen deprivation therapy has been the mainstay of treatment for metastatic prostate cancer and of less advanced cancers as neoadjuvant and adjuvant treatment. Abnormal liver function test, in particular elevated transaminases, is an adverse reaction more frequently noticed during androgen deprivation therapy with antiandrogen. We report the case of a patient with acute hepatic failure associated with the use of bicalutamide.
Castro Beza
Inmaculada
I
Department of Radiation Oncology, Hospital Punta de Europa, Algeciras, Cádiz, Spain. icastro78@yahoo.es
Sánchez Ruiz
Jesús
J
Peracaula Espino
Francisco José
FJ
Villanego Beltrán
M Isabel
MI
D000726:Androgen Antagonists / Q000009:adverse effects*; D000813:Anilides / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D017809:Fatal Outcome; D006801:Humans; D017114:Liver Failure, Acute / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D009570:Nitriles / Q000009:adverse effects*; D011471:Prostatic Neoplasms / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D014105:Tosyl Compounds / Q000009:adverse effects*; D000637:Transaminases / Q000097:blood; D016896:Treatment Outcome
D000726:Androgen Antagonists; D000813:Anilides; D009570:Nitriles; D014105:Tosyl Compounds; C053541:bicalutamide; D000637:Transaminases
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