New butyrylcholinesterase inhibitory steroid and peroxy acid from Leucas urticifolia.
A new steroid leucisterol (1) and a new peroxy acid urticic acid (2) along with methoxybenzyl benzoate (3), 4-hydroxy benzoic acid (4), beta-sitosterol (5), and ursolic acid (6), have been isolated from the chloroform soluble fraction of the whole plant of Leucas urticifolia. Their structures were elucidated on the basis of nuclear magnetic resonance (1D and 2D NMR) spectral data. Leucisterol showed potent inhibitory activity against butyrylcholinesterase enzyme.
Fatima
Itrat
I
International Center for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.
Ahmad
Ijaz
I
Anis
Itrat
I
Malik
Abdul
A
Afza
Nighat
N
Iqbal
Lubna
L
Latif
Mehreen
M
D002091:Butyrylcholinesterase / Q000378:metabolism*; D002800:Cholinesterase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D005229:Fatty Acids, Monounsaturated / Q000302:isolation & purification / Q000494:pharmacology*; D019686:Lamiaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008970:Molecular Weight; D010545:Peroxides / Q000302:isolation & purification / Q000494:pharmacology*; D010840:Phytosterols / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013256:Steroids / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D002800:Cholinesterase Inhibitors; D005229:Fatty Acids, Monounsaturated; D010545:Peroxides; D010840:Phytosterols; D010936:Plant Extracts; D013256:Steroids; C532261:leucisterol; C532262:urticic acid; D002091:Butyrylcholinesterase