Effect of adhesive matrix composition and terpinolene on indomethacin bioavailability in rats from transdermal therapeutic system.
Drug-in-adhesive matrix-type transdermal therapeutic systems for indomethacin (IND) were formulated and evaluated. Silicone and two types of polyacrylates were used as the bases of matrices. Terpinolene was used as a penetration enhancer. The physicochemical properties of matrices were determined. The bioavailability study of IND was performed in rats. The presence of IND in blood was demonstrated for each system. The calculated pharmacokinetics parameters for IND mainly depend on the solubility of IND in the adhesive layer. The positive influence of a penetration enhancer on IND bioavailability was observed only for one type of polyacrylate matrices.
Cal
Krzysztof
K
Department of Pharmaceutical Technology, Medical University of Gdansk, Gdansk, Poland. kcal@wp.pl
Sznitowska
Malgorzata
M
Janicki
Stanislaw
S
D000279:Administration, Cutaneous; D000818:Animals; D001682:Biological Availability; D000081005:Cyclohexane Monoterpenes; D007213:Indomethacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012828:Silicones / Q000008:administration & dosage; D012867:Skin / Q000378:metabolism*; D012995:Solubility; D013729:Terpenes / Q000494:pharmacology*
D000081005:Cyclohexane Monoterpenes; D012828:Silicones; D013729:Terpenes; C027009:terpinolene; D007213:Indomethacin