[Anticardiolipin and anti-beta2 glycoprotein-1 antibodies patients with breast carcinoma: a pilot study].
BACKGROUND
Thrombosis - the main manifestation of antiphospholipid syndrome (APS) - is at the same time observed in some patients with malignancies.


OBJECTIVE
Evaluation of prevalence of some antiphospholipid antibodies (aPL) in serum of patients with breast carcinoma and the possible correlation between aPL seropositivity and clinical symptoms.


METHODS
40 patients with breast carcinoma and 38 patients with non-malignant diseases of breast were studied. Anticardiolipin antibodies (aCL) and antibodies to beta2 glycoprotein-I (anti-beta2GPI) were detected by ELISA.


RESULTS
The aCL as well as anti-beta2GPI were positive in 1 patient with breast carcinoma, who at the same time presented with symptoms of APS. In the control group 2 patients were positive for anti-beta2GPI.


CONCLUSIONS
We have not observed a difference of aPL prevalence between the group of patients with breast carcinoma and controls. The association of breast cancer and aPL seropositivity deserves further investigations.
Zimmermann-Górska
Irena
I
Katedra i Klinika Reumatologiczno-Rehabilitacyjna i Chorób Wewnetrznych, Uniwersytet Medyczny im. Karola Marcinkowskiego, Poznań. zimmermanngorska@hotmail.com
Grodecka-Gazdecka
Sylwia
S
Białkowska-Puszczewicz
Grazyna
G
Puszczewicz
Mariusz
M
Goździecka
Magdalena
M
Kondarewicz
Paweł
P
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017153:Antibodies, Anticardiolipin / Q000097:blood*; D000925:Anticoagulants / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood / Q000276:immunology*; D002277:Carcinoma / Q000097:blood / Q000276:immunology*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008875:Middle Aged; D010865:Pilot Projects; D012016:Reference Values; D012307:Risk Factors; D053482:beta 2-Glycoprotein I / Q000097:blood*
D017153:Antibodies, Anticardiolipin; D000925:Anticoagulants; D053482:beta 2-Glycoprotein I