The CCN family of proteins: structure-function relationships.
The CCN proteins are key signalling and regulatory molecules involved in many vital biological functions, including cell proliferation, angiogenesis, tumourigenesis and wound healing. How these proteins influence such a range of functions remains incompletely understood but is probably related to their discrete modular nature and a complex array of intra- and inter-molecular interactions with a variety of regulatory proteins and ligands. Although certain aspects of their biology can be attributed to the four individual modules that constitute the CCN proteins, recent results suggest that some of their biological functions require cooperation between modules. Indeed, the modular structure of CCN proteins provides important insight into their structure-function relationships.
Holbourn
Kenneth P
KP
Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK.
Acharya
K Ravi
KR
Perbal
Bernard
B
D000595:Amino Acid Sequence; D000818:Animals; D055511:CCN Intercellular Signaling Proteins / Q000737:chemistry* / Q000502:physiology*; D002455:Cell Division; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000737:chemistry / Q000502:physiology; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000503:physiopathology; D018919:Neovascularization, Physiologic; D011487:Protein Conformation; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D014945:Wound Healing
D055511:CCN Intercellular Signaling Proteins; D018969:Insulin-Like Growth Factor Binding Proteins
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