Multiscale agent-based cancer modeling.
Agent-based modeling (ABM) is an in silico technique that is being used in a variety of research areas such as in social sciences, economics and increasingly in biomedicine as an interdisciplinary tool to study the dynamics of complex systems. Here, we describe its applicability to integrative tumor biology research by introducing a multi-scale tumor modeling platform that understands brain cancer as a complex dynamic biosystem. We summarize significant findings of this work, and discuss both challenges and future directions for ABM in the field of cancer research.
Zhang
Le
L
Harvard-MIT (HST) Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Wang
Zhihui
Z
Sagotsky
Jonathan A
JA
Deisboeck
Thomas S
TS
D000465:Algorithms; D001932:Brain Neoplasms / Q000473:pathology / Q000503:physiopathology; D019295:Computational Biology; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000473:pathology / Q000503:physiopathology; D049490:Systems Biology
Neuro Oncol. 1999 Jan;1(1):44-51
11550301
J Theor Biol. 2006 Nov 7;243(1):98-113
16860344
Biosystems. 2000 Feb;55(1-3):119-27
10745115
J Theor Biol. 2007 Jan 7;244(1):96-107
16949103
J Appl Physiol (1985). 1995 Jan;78(1):349-58
7713836
J Neurosurg. 1994 Sep;81(3):427-36
8057151
Proc Natl Acad Sci U S A. 2002 May 14;99 Suppl 3:7280-7
12011407
J Neurol Sci. 2003 Dec 15;216(1):1-10
14607296
J Math Biol. 1998 Sep;37(3):235-52
9785481
Biophys J. 1993 Dec;65(6):2673-9
8312501
J Theor Biol. 2006 Feb 21;238(4):771-9
16126230
Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1994 Feb;49(2):1685-9
9961383
Acta Biotheor. 2002;50(4):223-37
12675529
Int J Cancer. 1994 Jan 2;56(1):72-7
8262681
Proc Natl Acad Sci U S A. 2002 May 14;99 Suppl 3:7199-200
11997445
Cell Prolif. 2000 Oct;33(5):317-29
11063134
Expert Rev Anticancer Ther. 2006 Oct;6(10):1361-76
17069522
PLoS Comput Biol. 2006 Aug 18;2(8):e108
16933983
J Theor Biol. 2003 Oct 7;224(3):325-37
12941591
Acta Neuropathol. 1992;84(2):190-7
1523973
Bull Math Biol. 1998 Sep;60(5):857-99
9739618
J Theor Biol. 2002 Dec 7;219(3):343-70
12419662
Cell. 2006 Dec 1;127(5):905-15
17129778
Shock. 2001 Oct;16(4):266-73
11580108
Br J Cancer. 2002 Jan 7;86(1):14-8
11857005
Cancer Res. 2004 Oct 1;64(19):6892-9
15466178
Int J Cancer. 1996 Jul 17;67(2):275-82
8760599
Phys Rev E Stat Nonlin Soft Matter Phys. 2005 May;71(5 Pt 1):051910
16089574
J Theor Biol. 2005 Nov 7;237(1):1-16
15935392
J Theor Biol. 2004 Aug 7;229(3):395-411
15234206
J Neurosci Res. 1982;8(2-3):491-507
6296418
Biosystems. 2005 Apr;80(1):57-69
15740835
IMA J Math Appl Med Biol. 1997 Sep;14(3):189-205
9306674
FASEB J. 2004 Apr;18(6):731-3
14766791
Math Comput Model. 2009 Jan 1;49(1-2):307-319
20047002
Philos Trans A Math Phys Eng Sci. 2006 Jun 15;364(1843):1563-78
16766361
Chaos. 1995;5(1):82-7
11538314
Biophys J. 1994 Jul;67(1):64-70
7919025
Crit Care Med. 2004 Oct;32(10):2050-60
15483414
Cancer Res. 1990 Sep 15;50(18):6039-44
2393868
J Theor Biol. 2004 Dec 7;231(3):357-76
15501468
J Theor Biol. 2005 Apr 21;233(4):469-81
15748909