Effect of work conditions and work environments on the formation of 8-OH-dG in nurses and non-nurse female workers.
The purpose of our study was to examine the effects of job stress factors on oxidative DNA injuries among female workers. The levels of urinary 8-hydroxydeoxyguanosine (8-OH-dG) were measured along with a survey on work conditions and environments. The result showed that female workers in shift work excreted increased levels of 8-OH-dG in comparison with the result of those who were engaged in part time work (P < 0.01). Moreover, the nurses who marked higher depressive scores excreted significantly increased levels of urinary 8-OH-dG than the nurses who scored lower depressive states. The result revealed a positive correlation between 8-OH-dG levels of nurses in the 35-45 age group and the individual scores of their depressive states (r = 0.32, P < 0.05). Together, it was suggested that a heavy burden of work in addition to daily domestic roles increases urinary excretion levels of 8-OH-dG.
Ishihara
Itsuko
I
Department of Public Health and Occupational Health Nursing, School of Health Sciences, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Nakano
Masahiro
M
Ikushima
Miharu
M
Hara
Yoshiko
Y
Yoshimine
Toshiko
T
Haraga
Miki
M
Nakatani
Junko
J
Kawamoto
Rieko
R
Kasai
Hiroshi
H
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000293:Adolescent; D000328:Adult; D000368:Aged; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000652:urine; D003863:Depression / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009726:Nurses; D013315:Stress, Psychological / Q000652:urine
D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine