title: Gastrointestinal symptoms in a sample of children with pervasive developmental disorders.
abstract: Objective To evaluate gastrointestinal (GI) problems in a large, well-characterized sample of children with pervasive developmental disorders (PDDs). Methods One hundred seventy two children entering one of two trials conducted by the Research Units on Pediatric Psychopharmacology (RUPP) Autism Network were assessed comprehensively prior to starting treatment and classified with regard to GI symptoms. Results Thirty nine (22.7%) were positive for GI problems, primarily constipation and diarrhea. Those with GI problems were no different from subjects without GI problems in demographic characteristics, measures of adaptive functioning, or autism symptom severity. Compared to children without GI problems, those with GI problems showed greater symptom severity on measures of irritability, anxiety, and social withdrawal. Those with GI problems were also less likely to respond to treatment.
authors.affiliation: Yale Child Study Center, Yale University, P.O. Box 207900, New Haven, CT, USA. roumen.nikolov@yale.edu
authors.forename: Roumen N
authors.initials: RN
authors.lastname: Nikolov
authors.forename: Karen E
authors.initials: KE
authors.lastname: Bearss
authors.forename: Jelle
authors.initials: J
authors.lastname: Lettinga
authors.forename: Craig
authors.initials: C
authors.lastname: Erickson
authors.forename: Maria
authors.initials: M
authors.lastname: Rodowski
authors.forename: Michael G
authors.initials: MG
authors.lastname: Aman
authors.forename: James T
authors.initials: JT
authors.lastname: McCracken
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: McDougle
authors.forename: Elaine
authors.initials: E
authors.lastname: Tierney
authors.forename: Benedetto
authors.initials: B
authors.lastname: Vitiello
authors.forename: L Eugene
authors.initials: LE
authors.lastname: Arnold
authors.forename: Bhavik
authors.initials: B
authors.lastname: Shah
authors.forename: David J
authors.initials: DJ
authors.lastname: Posey
authors.forename: Louise
authors.initials: L
authors.lastname: Ritz
authors.forename: Lawrence
authors.initials: L
authors.lastname: Scahill
mesh_terms: D000223:Adaptation, Psychological; D000293:Adolescent; D001007:Anxiety / Q000523:psychology*; D001321:Autistic Disorder / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology*; D002648:Child; D002675:Child, Preschool; D003248:Constipation / Q000503:physiopathology*; D003967:Diarrhea / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D012720:Severity of Illness Index; D012920:Social Behavior Disorders / Q000523:psychology*
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