title: MYH9 is associated with nondiabetic end-stage renal disease in African Americans.
abstract: As end-stage renal disease (ESRD) has a four times higher incidence in African Americans compared to European Americans, we hypothesized that susceptibility alleles for ESRD have a higher frequency in the West African than the European gene pool. We carried out a genome-wide admixture scan in 1,372 ESRD cases and 806 controls and found a highly significant association between excess African ancestry and nondiabetic ESRD (lod score = 5.70) but not diabetic ESRD (lod = 0.47) on chromosome 22q12. Each copy of the European ancestral allele conferred a relative risk of 0.50 (95% CI = 0.39-0.63) compared to African ancestry. Multiple common SNPs (allele frequencies ranging from 0.2 to 0.6) in the gene encoding nonmuscle myosin heavy chain type II isoform A (MYH9) were associated with two to four times greater risk of nondiabetic ESRD and accounted for a large proportion of the excess risk of ESRD observed in African compared to European Americans.
authors.affiliation: Department of Epidemiology, School of Medicine and Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21287, USA. wkao@jhsph.edu
authors.forename: W H Linda
authors.initials: WH
authors.lastname: Kao
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Klag
authors.forename: Lucy A
authors.initials: LA
authors.lastname: Meoni
authors.forename: David
authors.initials: D
authors.lastname: Reich
authors.forename: Yvette
authors.initials: Y
authors.lastname: Berthier-Schaad
authors.forename: Man
authors.initials: M
authors.lastname: Li
authors.forename: Josef
authors.initials: J
authors.lastname: Coresh
authors.forename: Nick
authors.initials: N
authors.lastname: Patterson
authors.forename: Arti
authors.initials: A
authors.lastname: Tandon
authors.forename: Neil R
authors.initials: NR
authors.lastname: Powe
authors.forename: Nancy E
authors.initials: NE
authors.lastname: Fink
authors.forename: John H
authors.initials: JH
authors.lastname: Sadler
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Weir
authors.forename: Hanna E
authors.initials: HE
authors.lastname: Abboud
authors.forename: Sharon G
authors.initials: SG
authors.lastname: Adler
authors.forename: Jasmin
authors.initials: J
authors.lastname: Divers
authors.forename: Sudha K
authors.initials: SK
authors.lastname: Iyengar
authors.forename: Barry I
authors.initials: BI
authors.lastname: Freedman
authors.forename: Paul L
authors.initials: PL
authors.lastname: Kimmel
authors.forename: William C
authors.initials: WC
authors.lastname: Knowler
authors.forename: Orly F
authors.initials: OF
authors.lastname: Kohn
authors.forename: Kristopher
authors.initials: K
authors.lastname: Kramp
authors.forename: David J
authors.initials: DJ
authors.lastname: Leehey
authors.forename: Susanne B
authors.initials: SB
authors.lastname: Nicholas
authors.forename: Madeleine V
authors.initials: MV
authors.lastname: Pahl
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Schelling
authors.forename: John R
authors.initials: JR
authors.lastname: Sedor
authors.forename: Denyse
authors.initials: D
authors.lastname: Thornley-Brown
authors.forename: Cheryl A
authors.initials: CA
authors.lastname: Winkler
authors.forename: Michael W
authors.initials: MW
authors.lastname: Smith
authors.forename: Rulan S
authors.initials: RS
authors.lastname: Parekh
mesh_terms: D001741:Black or African American / Q000235:genetics; D016022:Case-Control Studies; D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics*; D015331:Cohort Studies; D017931:DNA Primers / Q000737:chemistry; D003920:Diabetes Mellitus / Q000235:genetics* / Q000473:pathology; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D015894:Genome, Human; D005923:Glomerulosclerosis, Focal Segmental / Q000235:genetics / Q000473:pathology; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000235:genetics* / Q000473:pathology; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D020409:Molecular Motor Proteins / Q000235:genetics*; D018995:Myosin Heavy Chains / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011446:Prospective Studies; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: D017931:DNA Primers; C103814:MYH9 protein, human; D020409:Molecular Motor Proteins; D018995:Myosin Heavy Chains
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