title: Exposure assessment of French women and their newborns to tetrabromobisphenol-A: occurrence measurements in maternal adipose tissue, serum, breast milk and cord serum.
abstract: A French monitoring study was initiated to evaluate the exposure of fetus and newborn to brominated flame retardants (BFR). A previously developed multi-residue analytical method was used for measuring the main classes of BFR (tetrabromobisphenol-A, and tri- to decabomodiphenyl ethers) in various human biological matrices. Analyzed samples (maternal and cord serum, adipose tissue and breast milk) were collected from 93 volunteer women during caesarean deliveries. TBBPA was detected in 44% of the analyzed breast milk samples, at levels varying from 0.06 to 37.34 ng g(-1) lipid weight, but was not detected in adipose tissue. This compound was also detected in 30% of the analyzed serum samples, with similar average values in maternal and cord serum (154 pg g(-1) fresh weight versus 199 pg g(-1) fresh weight, respectively). The interpretation of the collected data permitted the demonstration of (1) a significant exposure to TBBPA both for mothers and fetuses and (2) a possible risk of overexposure of newborns through breastfeeding.
authors.affiliation: Laboratoire d'Etude des Résidus et Contaminants dans les Aliments, USC INRA 2013, Ecole Nationale Vétérinaire de Nantes, BP 50707, F-44307 Nantes Cedex 3, France. laberca@vet-nantes.fr
authors.forename: Ronan
authors.initials: R
authors.lastname: Cariou
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Antignac
authors.forename: Daniel
authors.initials: D
authors.lastname: Zalko
authors.forename: Alain
authors.initials: A
authors.lastname: Berrebi
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Cravedi
authors.forename: Daniel
authors.initials: D
authors.lastname: Maume
authors.forename: Philippe
authors.initials: P
authors.lastname: Marchand
authors.forename: Fabrice
authors.initials: F
authors.lastname: Monteau
authors.forename: Anne
authors.initials: A
authors.lastname: Riu
authors.forename: François
authors.initials: F
authors.lastname: Andre
authors.forename: Bruno
authors.initials: B
authors.lastname: Le Bizec
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry*; D001942:Breast Feeding; D002585:Cesarean Section; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005411:Flame Retardants / Q000032:analysis*; D005602:France; D006801:Humans; D007231:Infant, Newborn; D018811:Maternal Exposure; D008895:Milk, Human / Q000737:chemistry*; D009035:Mothers; D011075:Polybrominated Biphenyls / Q000032:analysis* / Q000097:blood; D011247:Pregnancy
chemical_list: D005411:Flame Retardants; D011075:Polybrominated Biphenyls; C020806:tetrabromobisphenol A