Metastatic hepatic epithelioid hemangioendothelioma in a teenage girl.
Hepatic epithelioid hemangioendothelioma (HEHE) is a rare malignant tumor characterized by its epithelioid structure and vascular endothelium origin. The clinical course of HEHE is variable, ranging from long-term survival without treatment to a rapidly progressive course with a fatal outcome. As a consequence, no standard treatment has been determined. We present a case of HEHE occurring in a 13-year-old girl, in which a novel treatment approach using antiangiogenic therapy was tried and was successful in slowing the progression of the disease.
Kassam
Alisha
A
Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Mandel
Karen
K
D000293:Adolescent; D020533:Angiogenesis Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016190:Carboplatin / Q000008:administration & dosage; D000068579:Celecoxib; D002945:Cisplatin / Q000008:administration & dosage; D018450:Disease Progression; D004317:Doxorubicin / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D018323:Hemangioendothelioma, Epithelioid / Q000098:blood supply / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use; D017093:Liver Failure / Q000209:etiology / Q000601:surgery; D008113:Liver Neoplasms / Q000098:blood supply / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D016031:Liver Transplantation / Q000941:ethics; D008175:Lung Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary*; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000209:etiology; D011720:Pyrazoles / Q000008:administration & dosage / Q000627:therapeutic use; D011859:Radiography; D011994:Recombinant Proteins; D013449:Sulfonamides / Q000008:administration & dosage / Q000627:therapeutic use; D013792:Thalidomide / Q000008:administration & dosage / Q000627:therapeutic use; D014747:Vinblastine / Q000008:administration & dosage / Q000627:therapeutic use
D020533:Angiogenesis Inhibitors; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011720:Pyrazoles; D011994:Recombinant Proteins; D013449:Sulfonamides; D013792:Thalidomide; D014747:Vinblastine; D004317:Doxorubicin; D016190:Carboplatin; D000068579:Celecoxib; D002945:Cisplatin