title: Task-evoked BOLD responses are normal in areas of diaschisis after stroke.
abstract: OBJECTIVE
  Cerebral infarction can cause diaschisis, a reduction of blood flow and metabolism in areas of the cortex distant from the site of the lesion. Although the functional magnetic resonance imaging (fMRI) blood oxygen level dependent (BOLD) signal is increasingly used to examine the neural correlates of recovery in stroke, its reliability in areas of diaschisis is uncertain.
  
  
  METHODS
  The effect of chronic diaschisis as measured by resting positron emission tomography on task-evoked BOLD responses during word-stem completion in a block design fMRI study was examined in 3 patients, 6 months after a single left hemisphere stroke involving the inferior frontal gyrus and operculum.
  
  
  RESULTS
  The BOLD responses were minimally affected in areas of chronic diaschisis.
  
  
  CONCLUSIONS
  Within the confines of this study, the mechanism underlying the BOLD signal, which includes a mismatch between neuronally driven increases in blood flow and a corresponding increase in oxygen use, appears to be intact in areas of chronic diaschisis.
authors.affiliation: Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA. damien.fair@wustl.edu
authors.forename: Damien A
authors.initials: DA
authors.lastname: Fair
authors.forename: Abraham Z
authors.initials: AZ
authors.lastname: Snyder
authors.forename: Lisa Tabor
authors.initials: LT
authors.lastname: Connor
authors.forename: Binyam
authors.initials: B
authors.lastname: Nardos
authors.forename: Maurizio
authors.initials: M
authors.lastname: Corbetta
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D001931:Brain Mapping; D002536:Cerebral Arteries / Q000473:pathology / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology*; D007091:Image Processing, Computer-Assisted; D007806:Language Disorders / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009483:Neuropsychological Tests; D010101:Oxygen Consumption / Q000502:physiology; D049268:Positron-Emission Tomography / Q000379:methods*; D011237:Predictive Value of Tests; D020521:Stroke / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology*
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