Function and dysfunction of the PI system in membrane trafficking.
The phosphoinositides (PIs) function as efficient and finely tuned switches that control the assembly-disassembly cycles of complex molecular machineries with key roles in membrane trafficking. This important role of the PIs is mainly due to their versatile nature, which is in turn determined by their fast metabolic interconversions. PIs can be tightly regulated both spatially and temporally through the many PI kinases (PIKs) and phosphatases that are distributed throughout the different intracellular compartments. In spite of the enormous progress made in the past 20 years towards the definition of the molecular details of PI-protein interactions and of the regulatory mechanisms of the individual PIKs and phosphatases, important issues concerning the general principles of the organisation of the PI system and the coordination of the different PI-metabolising enzymes remain to be addressed. The answers should come from applying a systems biology approach to the study of the PI system, through the integration of analyses of the protein interaction data of the PI enzymes and the PI targets with those of the 'phenomes' of the genetic diseases that involve these PI-metabolising enzymes.
Vicinanza
Mariella
M
Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy.
D'Angelo
Giovanni
G
Di Campli
Antonella
A
De Matteis
Maria Antonietta
MA
D019870:1-Phosphatidylinositol 4-Kinase / Q000235:genetics / Q000378:metabolism; D000818:Animals; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007425:Intracellular Membranes / Q000737:chemistry / Q000378:metabolism; D008563:Membrane Lipids / Q000737:chemistry / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism*; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics / Q000378:metabolism; D021381:Protein Transport / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D008563:Membrane Lipids; D010716:Phosphatidylinositols; D019870:1-Phosphatidylinositol 4-Kinase; D010744:Phosphoric Monoester Hydrolases
Traffic. 2003 Nov;4(11):754-71
14617358
EMBO J. 1999 Feb 15;18(4):871-81
10022830
Mol Biol Cell. 2008 Apr;19(4):1415-26
18256276
Curr Opin Cell Biol. 1998 Aug;10(4):542-9
9719877
Biochemistry. 2007 Sep 25;46(38):10909-20
17713930
J Am Soc Nephrol. 2002 Aug;13(8):2171-7
12138151
J Biol Chem. 2007 Sep 21;282(38):28226-36
17644513
Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):11934-9
16880396
J Biol Chem. 2005 Apr 29;280(17):17346-52
15741173
Nat Rev Neurosci. 2007 Dec;8(12):921-34
17971783
Mol Cell. 2002 Jan;9(1):95-108
11804589
Biochem Biophys Res Commun. 2006 Apr 7;342(2):537-46
16487940
J Biol Chem. 2008 Feb 1;283(5):2804-13
18039667
Science. 2002 Aug 16;297(5584):1193-6
12183633
Nat Cell Biol. 1999 Aug;1(4):249-52
10559924
Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12177-82
14530412
J Cell Sci. 1999 Jun;112 ( Pt 12):1957-65
10341214
J Biol Chem. 2000 May 5;275(18):13901-6
10788515
Traffic. 2007 Nov;8(11):1554-67
17908202
J Biol Chem. 2002 Nov 22;277(47):44898-904
12244116
Mol Biol Cell. 2006 Nov;17(11):4856-65
16971510
Autophagy. 2007 Jan-Feb;3(1):35-7
16969129
Traffic. 2005 Sep;6(9):711-9
16101675
Nat Rev Mol Cell Biol. 2008 Feb;9(2):99-111
18216767
Biochem Soc Trans. 2004 Apr;32(Pt 2):393-6
15046615
J Cell Sci. 2006 Nov 15;119(Pt 22):4650-66
17077126
Biochem J. 2002 May 1;363(Pt 3):657-66
11964166
EMBO J. 2002 Sep 16;21(18):4915-26
12234931
Biochem Biophys Res Commun. 2006 Jul 7;345(3):1264-72
16712798
J Cell Biol. 2008 Feb 25;180(4):803-12
18299350
EMBO J. 2006 Aug 23;25(16):3750-61
16902405
FEBS Lett. 2007 Feb 20;581(4):644-50
17257598
J Cell Sci. 2006 Jul 15;119(Pt 14):2953-9
16787938
Curr Biol. 1998 Nov 5;8(22):1219-22
9811604
Mol Cell. 2001 Feb;7(2):443-9
11239472
Proc Natl Acad Sci U S A. 2002 May 14;99(10):6767-72
11997453
Mol Biol Cell. 2008 Feb;19(2):711-21
18077555
FEBS Lett. 2004 Feb 13;559(1-3):77-83
14960311
Science. 2001 Feb 9;291(5506):1047-51
11161217
Biochim Biophys Acta. 2007 Jun;1771(6):761-8
17500031
Curr Opin Cell Biol. 2005 Apr;17(2):141-9
15780590
J Cell Sci. 2005 Aug 1;118(Pt 15):3555-66
16079295
Mol Genet Metab. 2006 Sep-Oct;89(1-2):121-8
16777452
J Biol Chem. 2006 Nov 24;281(47):36369-77
17003043
Nat Cell Biol. 2007 Feb;9(2):176-83
17187061
J Biol Chem. 2005 Feb 18;280(7):6109-17
15533940
Nat Cell Biol. 2001 Jul;3(7):658-66
11433298
J Biol Chem. 2000 Mar 31;275(13):9653-63
10734117
Physiology (Bethesda). 2005 Aug;20:271-84
16024515
Nat Rev Drug Discov. 2006 Nov;5(11):903-18
17080027
J Biol Chem. 2004 Apr 2;279(14):14294-306
14732715
Nature. 2004 May 20;429(6989):309-14
15152255
Curr Opin Cell Biol. 2006 Aug;18(4):371-8
16806880
J Cell Physiol. 2006 Mar;206(3):586-93
16222711
Am J Hum Genet. 2005 Feb;76(2):260-7
15627218
Eur J Biochem. 1997 Apr 15;245(2):512-9
9151987
J Cell Biol. 2000 Oct 30;151(3):627-38
11062263
J Biol Chem. 2003 Sep 5;278(36):34617-30
12813048
Nat Cell Biol. 2005 May;7(5):501-9
15821731
Biochem J. 2006 Aug 15;398(1):1-13
16856876
J Biol Chem. 2005 Apr 1;280(13):12799-809
15632132
Nature. 2000 Nov 16;408(6810):369-73
11099045
J Biol Chem. 1998 Apr 24;273(17):10240-8
9553075
Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16099-104
12451172
Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3640-5
10097090
Immunol Rev. 2007 Oct;219:17-36
17850479
Annu Rev Cell Dev Biol. 2003;19:287-332
14570572
Mol Biol Cell. 2008 Jul;19(7):2718-28
18434594
J Biol Chem. 2004 Oct 22;279(43):44683-9
15271978
EMBO Rep. 2007 Mar;8(3):241-6
17330069
J Cell Biol. 2002 Jul 22;158(2):209-14
12119359
J Biol Chem. 2007 Nov 2;282(44):32093-105
17823121
Mol Cell. 2002 Jan;9(1):109-19
11804590
Nature. 2005 Dec 1;438(7068):597-604
16319879
J Cell Biol. 2005 Aug 15;170(4):607-18
16103228
Pediatr Nephrol. 2004 Jul;19(7):714-21
15146321
Curr Opin Cell Biol. 2008 Aug;20(4):360-70
18490149
Proc Natl Acad Sci U S A. 2004 Jan 13;101(2):546-51
14704270
J Biol Chem. 2002 Dec 13;277(50):48730-6
12198132
J Biol Chem. 2006 Dec 1;281(48):36891-6
17012226
Curr Opin Cell Biol. 2002 Apr;14(2):203-13
11891120
Mol Biol Cell. 2003 Feb;14(2):625-41
12589059
Nat Cell Biol. 2004 Jun;6(6):487-92
15170460
J Biol Chem. 2007 Aug 17;282(33):23878-91
17556371
J Biol Chem. 2002 Dec 13;277(50):48965-75
12388557
Dev Cell. 2007 Dec;13(6):796-811
18061563
J Biol Chem. 2008 Jul 11;283(28):19836-44
18490450
Mol Biol Cell. 2007 Jul;18(7):2646-55
17494868
Cell. 2003 Aug 8;114(3):299-310
12914695
Nat Cell Biol. 2002 Jul;4(7):469-77
12055636
Cell. 2006 May 19;125(4):801-14
16713569
Dev Cell. 2007 Sep;13(3):377-90
17765681
J Biol Chem. 1997 Jun 20;272(25):15986-92
9188501
FEBS Lett. 2001 Feb 9;490(1-2):79-83
11172815
J Cell Sci. 2008 Apr 15;121(Pt 8):1252-63
18388313
Methods Enzymol. 2003;360:238-58
12622153
Nature. 2003 Dec 18;426(6968):803-9
14685229
J Am Soc Nephrol. 2002 Jan;13(1):125-133
11752029
Science. 2001 Nov 30;294(5548):1939-42
11729322
Nature. 2006 Oct 12;443(7112):651-7
17035995
J Cell Sci. 2001 Jun;114(Pt 12):2255-63
11493665
J Cell Biol. 2002 Mar 18;156(6):1015-28
11889142
J Cell Biol. 2006 Feb 27;172(5):693-704
16492811
Mol Biol Cell. 2002 Nov;13(11):4060-73
12429846
Biochim Biophys Acta. 2008 Jan;1784(1):159-85
17997386
Traffic. 2007 Aug;8(8):1052-67
17651088
Science. 2001 Feb 9;291(5506):1051-5
11161218
Methods Enzymol. 2003;366:64-84
14674240
Biochem J. 1998 Apr 1;331 ( Pt 1):217-23
9512482
Nature. 1997 Nov 13;390(6656):187-92
9367158
J Cell Biol. 2000 Oct 30;151(3):601-12
11062261
Mol Biol Cell. 2007 Feb;18(2):688-96
17182843
Br J Pharmacol. 2007 Dec;152(8):1141-4
17922021
Cell. 2002 May 3;109(3):347-58
12015984
Nucleic Acids Res. 2008 Jan;36(Database issue):D77-82
17932064
Mol Biol Cell. 2008 Mar;19(3):1046-61
18172025
Curr Opin Cell Biol. 2006 Apr;18(2):168-78
16488588
J Cell Biol. 2007 Oct 8;179(1):101-15
17923531
Biochemistry. 2000 Oct 10;39(40):12485-93
11015230
Traffic. 2006 Nov;7(11):1539-50
17010122
Biochim Biophys Acta. 2007 Mar;1771(3):353-404
17382260
Clin Genet. 2007 Jan;71(1):1-11
17204041
Harvey Lect. 2004-2005;100:103-22
16970176
Nat Cell Biol. 1999 Sep;1(5):280-7
10559940
J Biol Chem. 1998 Sep 4;273(36):23126-33
9722541
Cell. 2005 May 6;121(3):437-50
15882625
Biochem Soc Symp. 2007;(74):129-39
17233586
Nat Cell Biol. 2004 May;6(5):393-404
15107860
Traffic. 2007 Oct;8(10):1365-74
17645435
Cell. 2006 Apr 7;125(1):99-111
16615893
Nat Cell Biol. 2005 Sep;7(9):880-6
16100512
Nat Rev Mol Cell Biol. 2008 Feb;9(2):151-61
18216771
Cell Signal. 2006 Nov;18(11):1906-13
16563698
Nat Rev Genet. 2006 Aug;7(8):606-19
16847462
Nat Rev Drug Discov. 2006 Apr;5(4):333-42
16582877
Nature. 1992 Jul 16;358(6383):239-42
1321346
Nat Cell Biol. 2005 Jan;7(1):48-55
15580264
Mol Cell. 1998 Jul;2(1):157-62
9702203
Nature. 2004 May 13;429(6988):141-3
15141195
J Cell Biol. 2006 Jul 31;174(3):425-36
16864656
Nature. 2007 Sep 6;449(7158):62-7
17687330