Diurnal variation of plasma brain-derived neurotrophic factor (BDNF) in humans: an analysis of sex differences.
Scant information is available on the diurnal variation of peripheral neurotrophic factors, including brain-derived neurotrophic factor (BDNF), in human beings. We explored plasma and serum BDNF levels at three different clock times in a study of 28 healthy subjects of both sexes. Statistically significant diurnal variation in plasma BDNF level was detected in men, with the peak at 08:00 h and nadir at 22:00 h. At this time, the plasma BDNF concentration of men was significantly lower than that of women (p=.02). However, no diurnal variation was found either in plasma BDNF of women, in either the follicular or luteal phases of the menstrual cycle, or in serum BDNF level in both men and women. These findings support the concept of rhythmic variation in plasma BDNF regulation that seems to be sex-related.
Piccinni
Armando
A
Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, Italy.
Marazziti
Donatella
D
Del Debbio
Alessandro
A
Bianchi
Carolina
C
Roncaglia
Isabella
I
Mannari
Claudio
C
Origlia
Nicola
N
Catena Dell'Osso
Mario
M
Massimetti
Gabriele
G
Domenici
Luciano
L
Dell'Osso
Liliana
L
D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D012727:Sex Characteristics; D013997:Time Factors
D019208:Brain-Derived Neurotrophic Factor