Uniformity in clinical and HLA-DR status regardless of age and gender within fulminant type 1 diabetes.
To clarify the detailed clinical features and HLA subtype in the patients with fulminant type 1 diabetes, we investigated consecutive 250 case records registered to the committee of the Japan Diabetes Society between 2000/7/15 and 2006/6/30. After the classification with age at onset or gender, clinical data and HLA DR were evaluated. As a result, the prevalence of male patients, BMI, HbA(1c) and ALT levels at the onset increased significantly according to the elder quartile, but no other data showed any significant difference. Only age at onset and blood glucose level were significantly higher in male patients than in female patients without pregnancy by multivariate analysis. The distribution of HLA DR was not different in any subtype by gender or age at onset. Our present study revealed common feature in clinical and HLA-DR status regardless of age and gender within fulminant type 1 diabetes except pregnant women.
Imagawa
Akihisa
A
First Department of Internal Medicine, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki 569-8686, Japan.
Hanafusa
Toshiaki
T
Iwahashi
Hiromi
H
Uchigata
Yasuko
Y
Kanatsuka
Azuma
A
Kawasaki
Eiji
E
Kobayashi
Tetsuro
T
Shimada
Akira
A
Shimizu
Ikki
I
Maruyama
Taro
T
Makino
Hideichi
H
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology* / Q000378:metabolism; D005260:Female; D006684:HLA-DR Antigens / Q000276:immunology*; D006801:Humans; D007223:Infant; D007564:Japan; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D012737:Sex Factors; D055815:Young Adult
D001786:Blood Glucose; D002096:C-Peptide; D006684:HLA-DR Antigens