title: Cost-effectiveness of different strategies for amplified Mycobacterium tuberculosis direct testing for cases of pulmonary tuberculosis.
abstract: We conducted a decision analysis to assess and compare four algorithms for amplified Mycobacterium tuberculosis direct (MTD) testing of respiratory specimens in terms of cost-effectiveness. The most cost-effective strategy was one in which smear-positive specimens but not smear-negative specimens were diluted prior to MTD testing.
authors.affiliation: Johns Hopkins University Center for Tuberculosis Research, 1550 Orleans Street, Room 1M-06, Baltimore, MD 21231, USA.
authors.forename: Renata L
authors.initials: RL
authors.lastname: Guerra
authors.forename: Nancy M
authors.initials: NM
authors.lastname: Hooper
authors.forename: James F
authors.initials: JF
authors.lastname: Baker
authors.forename: Roya
authors.initials: R
authors.lastname: Alborz
authors.forename: Derek T
authors.initials: DT
authors.lastname: Armstrong
authors.forename: Julia A
authors.initials: JA
authors.lastname: Kiehlbauch
authors.forename: Marcus B
authors.initials: MB
authors.lastname: Conde
authors.forename: Susan E
authors.initials: SE
authors.lastname: Dorman
mesh_terms: D003362:Cost-Benefit Analysis; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000302:isolation & purification*; D021141:Nucleic Acid Amplification Techniques / Q000191:economics* / Q000379:methods*; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis* / Q000382:microbiology
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