title: Advanced Lemierre syndrome requiring surgery.
abstract: A 38-year-old homeless man was admitted with a 2-week history of a sore throat, increasing shortness of breath, and high fever. Clinical examination showed enlarged and tender submandibular and anterior cervical lymph nodes and a pronounced enlargement of the left peritonsillar region (Figure 1a). CT scan of the throat and the chest showed left peritonsillar abscess formation, occlusion of the left internal jugular vein with inflammatory wall thickening and perijugular soft tissue infiltration, pulmonary abscesses, and bilateral pleural effusions (Figures 1b-e, arrowed). Anaerobe blood cultures grew Fusobacterium necrophorum, leading to the diagnosis of Lemierre's syndrome. Treatment with high-dose amoxicillin and clavulanic acid improved the oropharyngeal condition, but the patient's general status declined further, marked by dyspnea and tachypnea. Repeated CT scans showed progressive lung abscesses and bilateral pleural empyema. Bilateral tonsillectomy, ligation of the left internal jugular vein, and staged decortication of bilateral empyema were performed. Total antibiotic therapy duration was 9 weeks, including a change to peroral clindamycin. Clinical and laboratory findings had returned to normal 12 weeks after surgery.The patient's history and the clinical and radiological findings are characteristic for Lemierre's syndrome. CT scans of the neck and the chest are the diagnostic methods of choice. F. necrophorum is found in over 80% of cases of Lemierre's syndrome and confirms the diagnosis. Prolonged antibiotic therapy is usually sufficient, but in selected patients, a surgical intervention may be necessary. Reported mortality rates are high, but in surviving patients, the recovery of pulmonary function is usually good.
authors.affiliation: Division of Infectious Diseases, University Hospital, Bern, Switzerland. robert.escher@insel.ch
authors.forename: R
authors.initials: R
authors.lastname: Escher
authors.forename: S
authors.initials: S
authors.lastname: Haltmeier
authors.forename: N
authors.initials: N
authors.lastname: von Steiger
authors.forename: A E
authors.initials: AE
authors.lastname: Dutly
authors.forename: A
authors.initials: A
authors.lastname: Arnold
authors.forename: R
authors.initials: R
authors.lastname: Kickuth
authors.forename: U
authors.initials: U
authors.lastname: Schiemann
mesh_terms: D000328:Adult; D005674:Fusobacterium Infections / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery*; D005675:Fusobacterium necrophorum / Q000302:isolation & purification*; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008297:Male; D010614:Pharynx / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed