Effects of arginine residue introduction upon interaction and complexation behavior of peptide ribonucleic acids (PRNAs) with RNA: synthesis and properties of alpha-containing arginine.
A novel nucleic acid model using alpha-peptide ribonucleic acid (alpha-PRNA) possessing alternative alpha-PRNA/arginine sequences, where the arginine residue would be expected to stabilize the complex not only by the conventional hydrogen-bonding interactions between the complementary nucleobase pairs but also through the electrostatic interactions between positively charged side-chain groups and RNA's phosphate anions on the backbone. These alpha-PRNA form stable sequence-specific complex with the complementary RNA.
Wada
Takehiko
T
Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, Sendai, 980-8577, Miyagi, Japan. hiko@tagen.tohoku.ac.jp
Sawa
Nobuya
N
Sato
Hirofumi
H
Futaki
Shiroh
S
Inoue
Yoshihisa
Y
D001120:Arginine / Q000737:chemistry*; D001881:Borates / Q000737:chemistry; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry; D009691:Nucleic Acid Denaturation; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D012313:RNA / Q000138:chemical synthesis / Q000737:chemistry*
D001881:Borates; D009841:Oligonucleotides; D010455:Peptides; D012313:RNA; D004247:DNA; D001120:Arginine