title: Rapid and efficient microwave-assisted synthesis of highly sulfated organic scaffolds.
abstract: Sulfation of multiply hydroxylated small organic molecules is fraught with problems of poor yield, multitude of products and long reaction times. We have developed a rapid microwave-based method for synthesis of highly sulfated small organic molecules, which affords the per-sulfated product in moderate to excellent yields and high purity. The method is expected to be of value in the discovery of per-sulfated organic molecules as mimics of glycosaminoglycans, which are being increasingly recognized as modulators of key physiological functions.
authors.affiliation: Department of Medicinal Chemistry and Institute for Structural Biology and Drug Discovery, Richmond, VA, USA.
authors.forename: Arjun
authors.initials: A
authors.lastname: Raghuraman
authors.forename: Muhammad
authors.initials: M
authors.lastname: Riaz
authors.forename: Michael
authors.initials: M
authors.lastname: Hindle
authors.forename: Umesh R
authors.initials: UR
authors.lastname: Desai
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