The lens capsule.
The lens capsule is a modified basement membrane that completely surrounds the ocular lens. It is known that this extracellular matrix is important for both the structure and biomechanics of the lens in addition to providing informational cues to maintain lens cell phenotype. This review covers the development and structure of the lens capsule, lens diseases associated with mutations in extracellular matrix genes and the role of the capsule in lens function including those proposed for visual accommodation, selective permeability to infectious agents, and cell signaling.
Danysh
Brian P
BP
Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA.
Duncan
Melinda K
MK
D000065:Accommodation, Ocular; D000818:Animals; D001485:Basement Membrane / Q000378:metabolism; D001696:Biomechanical Phenomena; D002463:Cell Membrane Permeability; D005109:Extracellular Matrix / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D005128:Eye Diseases / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D006801:Humans; D007903:Lens Capsule, Crystalline / Q000196:embryology / Q000378:metabolism / Q000502:physiology*; D038081:Organogenesis / Q000502:physiology; D011247:Pregnancy; D015398:Signal Transduction / Q000502:physiology
D016326:Extracellular Matrix Proteins
Acta Anat (Basel). 1996;157(4):309-14
9259880
Semin Cell Dev Biol. 2006 Dec;17(6):726-40
17116415
Glycobiology. 2007 Sep;17(9):897-905
17442708
Dev Genet. 1989;10(4):287-91
2791349
Development. 1989 Oct;107(2):221-8
2632221
Invest Ophthalmol Vis Sci. 1995 Oct;36(11):2211-5
7558714
Ophthalmic Genet. 1997 Dec;18(4):161-73
9457747
J Cell Biol. 2002 Jun 24;157(7):1279-90
12082085
Invest Ophthalmol Vis Sci. 2000 Nov;41(12):3898-907
11053292
Eur J Biochem. 1992 Sep 1;208(2):359-66
1521532
Invest Ophthalmol Vis Sci. 1996 Jun;37(7):1282-93
8641831
Am J Anat. 1990 Feb;187(2):165-74
2301276
Matrix Biol. 2003 Sep;22(5):443-8
14614990
Histochem Cell Biol. 2007 Apr;127(4):363-74
17186266
Dev Dyn. 2000 Jun;218(2):213-34
10842354
Cell. 1998 Dec 11;95(6):859-70
9865703
Hum Mol Genet. 2007 Apr 1;16(7):798-807
17317786
Invest Ophthalmol Vis Sci. 1987 Nov;28(11):1761-6
3312076
Invest Ophthalmol Vis Sci. 2005 Dec;46(12):4652-60
16303962
J Mol Biol. 1998 Sep 11;282(1):99-109
9733643
Mol Vis. 2007 Mar 27;13:457-69
17417606
Histochem J. 1999 Mar;31(3):161-7
10421415
Am J Physiol. 1995 Dec;269(6 Pt 1):L766-75
8572238
Invest Ophthalmol Vis Sci. 2006 May;47(5):2053-60
16639015
J Biomech Eng. 2007 Feb;129(1):97-104
17227103
Vision Res. 1982;22(8):917-27
7135854
Vet Ophthalmol. 2000;3(4):227-234
11397308
Ann N Y Acad Sci. 1998 Apr 15;842:36-41
9599291
Bioessays. 2004 Apr;26(4):374-86
15057935
J Long Term Eff Med Implants. 1993;3(4):333-50
10146730
Biochem J. 1996 Nov 1;319 ( Pt 3):699-704
8920969
J Anat. 1995 Feb;186 ( Pt 1):31-42
7649817
J Biol Chem. 1995 Feb 17;270(7):3278-83
7531703
Brain Res Dev Brain Res. 2005 Apr 21;156(1):104-9
15862633
J Anat. 1998 Jul;193 ( Pt 1):1-21
9758133
Invest Ophthalmol Vis Sci. 2007 Jun;48(6):2483-90
17525174
Ophthalmic Res. 1999;31(5):337-45
10420118
Kidney Int. 2002 Sep;62(3):895-900
12164871
Invest Ophthalmol Vis Sci. 1987 Mar;28(3):506-14
3549611
Ophthalmology. 1979 Sep;86(9):1559-70
575919
Matrix Biol. 2002 Aug;21(5):415-23
12225806
Coll Relat Res. 1981;1(1):95-128
7049547
Proc Natl Acad Sci U S A. 1981 May;78(5):3218-21
6789333
J Biol Chem. 1969 Apr 25;244(8):2041-8
5781998
Arch Ophthalmol. 1993 May;111(5):706-8
8489458
FASEB J. 2003 Dec;17(15):2257-9
14525950
BMC Biochem. 2006 Jan 17;7:2
16417632
Vision Res. 2007 Jun;47(13):1781-9
17467027
Invest Ophthalmol Vis Sci. 1993 Nov;34(12):3355-65
7693608
J Anat. 1972 Jul;112(Pt 2):207-14
5077192
J Cataract Refract Surg. 1997 Mar;23(2):160-5
9113564
J Biotechnol. 2007 Apr 30;129(2):290-307
17337080
Matrix Biol. 2000 Dec;19(7):569-80
11102747
Biomech Model Mechanobiol. 2009 Jun;8(3):217-31
18622755
Invest Ophthalmol Vis Sci. 2002 Jul;43(7):2301-8
12091431
Dev Dyn. 2002 Mar;223(2):273-84
11836791
Cells Tissues Organs. 2005;179(1-2):43-55
15942192
Acta Ophthalmol (Copenh). 1976 Jul;54(3):301-10
181943
J Physiol. 1969 Mar;201(1):1-19
5773553
Dev Biol. 2007 Mar 1;303(1):165-80
17196957
Prog Retin Eye Res. 2003 Nov;22(6):749-67
14575723
BMC Dev Biol. 2006 Mar 07;6:13
16522196
Curr Eye Res. 1991 Jun;10(6):501-11
1893767
J Biochem. 1993 Sep;114(3):358-62
8282726
Genes Dev. 1996 Dec 1;10(23):2981-92
8956999
EMBO J. 1998 Aug 3;17(15):4249-56
9687493
EMBO J. 1991 Nov;10(11):3137-46
1717261
J AAPOS. 1999 Dec;3(6):381-2
10613586
J Cell Sci. 2002 Jul 1;115(Pt 13):2747-56
12077365
J Cataract Refract Surg. 1993 Mar;19(2):209-12
8487162
Int J Dev Biol. 1989 Dec;33(4):487-90
2641354
Exp Eye Res. 1973 Apr;15(4):441-59
4702379
J Opt Soc Am A Opt Image Sci Vis. 2002 Jan;19(1):144-51
11778717
Biochem J. 1978 Jan 1;169(1):55-9
629753
EMBO J. 2002 Apr 2;21(7):1535-44
11927538
Mol Cell Biol. 2002 Oct;22(19):6820-30
12215539
Exp Eye Res. 1970 Jul;10(1):8-14
5456784
Invest Ophthalmol Vis Sci. 1998 Jan;39(1):84-93
9430549
Histol Histopathol. 2007 Oct;22(10):1077-84
17616934
Int J Dev Biol. 2004;48(8-9):783-91
15558471
Invest Ophthalmol Vis Sci. 1997 Mar;38(3):569-78
9071209
Dev Biol. 2008 Jun 15;318(2):276-88
18455718
Mol Vis. 2008 May 09;14:857-61
18483563
Biosci Rep. 2001 Aug;21(4):537-63
11900326
Am J Anat. 1983 May;167(1):71-82
6346854
J Cell Biol. 1986 Nov;103(5):1689-97
2430974
Am J Med Genet A. 2004 Oct 1;130A(2):138-45
15372515
Vision Res. 1999 Jun;39(11):1991-2015
10343784
Exp Eye Res. 1981 Oct;33(4):447-58
7197633
Arch Ophthalmol. 1995 Jan;113(1):103-9
7826283
Am J Pathol. 1989 Apr;134(4):813-25
2650557
J Biol Chem. 1988 Mar 25;263(9):4302-8
3346249
Dev Dyn. 1997 Oct;210(2):130-45
9337134
Exp Eye Res. 1978 Feb;26(2):177-90
305361
Lab Invest. 2002 Dec;82(12):1617-30
12480912
Biochem J. 2005 Jul 1;389(Pt 1):145-50
15769253
Development. 2004 Apr;131(7):1619-28
14998921
Matrix Biol. 2008 Mar;27(2):150-60
17997086
Gene Expr Patterns. 2004 Oct;4(6):687-93
15465490
Mol Vis. 2008 Jun 30;14:1187-203
18596883
J Cataract Refract Surg. 1993 Mar;19(2):205-8
8487161
Arch Biochem Biophys. 1989 Mar;269(2):576-85
2521995
J Clin Invest. 1968 Sep;47(9):1973-99
5675423
Exp Eye Res. 1984 Jun;38(6):579-92
6468538
Hum Mol Genet. 2005 Nov 1;14(21):3161-8
16159887
Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3448-52
8159767
Mol Vis. 2002 Jul 10;8:226-34
12118240
Exp Eye Res. 1996 Mar;62(3):253-60
8690034
Invest Ophthalmol Vis Sci. 1999 Aug;40(9):2025-32
10440257
J Clin Invest. 2001 Jul;108(2):165-7
11457866
J Biol Chem. 1997 Dec 12;272(50):31525-32
9395489
Curr Probl Cardiol. 2008 Jan;33(1):7-39
18155514
Histochem J. 1986 Aug;18(8):405-12
3781873
J Biol Chem. 2004 Jan 23;279(4):2772-80
14610079
Trans Ophthalmol Soc U K. 1977 Apr;97(1):100-3
271370
Exp Cell Res. 1978 Aug;115(1):127-42
210028
Dev Biol. 2006 Nov 1;299(1):63-77
16973147
Invest Ophthalmol Vis Sci. 2007 Sep;48(9):4192-9
17724206
Nature. 2000 Apr 13;404(6779):725-8
10783877
Biochem Biophys Res Commun. 2000 Aug 18;275(1):53-9
10944440
J Histochem Cytochem. 1986 Jan;34(1):93-102
3510247
Dev Growth Differ. 2005 May;47(4):213-23
15921496
Invest Ophthalmol Vis Sci. 1997 Feb;38(2):357-63
9040468
Science. 2007 Sep 7;317(5843):1397-400
17690259
Curr Top Eye Res. 1980;3:281-330
7344838
J Struct Biol. 2000 Jul;131(1):44-55
10945969
Vet Ophthalmol. 2006 Sep-Oct;9(5):266-80
16939454
J Histochem Cytochem. 2003 Nov;51(11):1467-78
14566019
Lab Invest. 1987 Feb;56(2):170-9
3807316
Anat Rec. 1987 Jul;218(3):329-37
3631545
Dev Biol. 1961 Apr;3:175-209
13716849
Curr Opin Cell Biol. 2004 Oct;16(5):558-64
15363807
Development. 1999 Sep;126(17):3957-68
10433923
Diabetes. 1988 Aug;37(8):1144-50
3134265
Genes Dev. 2000 Sep 1;14(17):2123-33
10970876
Dev Biol. 2005 Apr 1;280(1):1-14
15766743
Arch Biochem Biophys. 1979 Dec;198(2):370-8
518091
Exp Eye Res. 2000 Jul;71(1):81-90
10880278
Curr Eye Res. 1989 Dec;8(12):1271-7
2697512
Invest Ophthalmol Vis Sci. 1977 Apr;16(4):364-75
844993
J Cell Biol. 1980 Aug;86(2):688-93
6447156
Anat Rec (Hoboken). 2008 Dec;291(12):1619-27
18951502
Eur J Biochem. 1999 Feb;259(3):917-25
10092882
Nature. 1968 Jan 6;217(5123):38-40
4865590
Am J Physiol. 1995 Feb;268(2 Pt 1):L336-46
7864154
Am J Physiol. 1996 Jan;270(1 Pt 1):L3-27
8772523
Mol Vis. 2008 Mar 17;14:533-41
18385788
Prog Retin Eye Res. 2007 Nov;26(6):555-97
17905638
Tissue Cell. 1986;18(1):83-97
3515629
J Am Soc Nephrol. 2005 Jun;16(6):1703-10
15872080
Coll Relat Res. 1985 Jun;5(3):233-44
2412754
Differentiation. 1984;27(1):53-8
6468804
Matrix Biol. 2001 Apr;20(2):77-85
11334709
Ophthalmic Genet. 2000 Dec;21(4):217-25
11135492
Biochemistry. 2005 Sep 13;44(36):12203-13
16142919
J Histochem Cytochem. 1999 Dec;47(12):1495-506
10567433
J Cell Biol. 1987 Dec;105(6 Pt 1):2559-68
3693393
J Cell Biol. 1996 Dec;135(5):1403-13
8947561
J Physiol. 1971 Jan;212(1):147-80
5101807
Ophthalmology. 1998 Jun;105(6):951-68
9627642
Int Ophthalmol Clin. 2006 Summer;46(3):39-61
16929224
Mol Cell Biol. 2000 Mar;20(6):2260-8
10688672
J Cell Sci. 1999 Jul;112 ( Pt 13):2155-65
10362545
EMBO J. 1998 Apr 1;17(7):1860-70
9524110
Bioessays. 1996 Feb;18(2):123-32
8851045
J Biol Chem. 2003 Feb 7;278(6):4238-49
12435733
Invest Ophthalmol. 1966 Dec;5(6):583-9
5954530
J Cataract Refract Surg. 1990 Sep;16(5):551-8
2231368
Ann Ophthalmol. 1994 Mar-Apr;26(2):36-8
8010701
J Exp Zool. 1971 Jan;176(1):15-24
4925671
Nat Genet. 1995 Aug;10(4):400-6
7670489
J Cataract Refract Surg. 1991 Jan;17(1):27-31
2005555
Trends Biochem Sci. 1991 Jul;16(7):268-71
1926336
Nat Rev Mol Cell Biol. 2005 Aug;6(8):646-56
16064139
J Am Soc Nephrol. 1991 Mar;1(9):1095-108
1912408
J Cataract Refract Surg. 1999 Feb;25(2):246-50
9951672
Invest Ophthalmol Vis Sci. 1984 Jan;25(1):108-12
6607906
Curr Eye Res. 1987 Sep;6(9):1165-9
3665571
Front Biosci. 1997 Mar 01;2:d126-46
9159220
FASEB J. 2005 May;19(7):716-28
15857886
Invest Ophthalmol Vis Sci. 1993 Sep;34(10):2825-34
8360016
Invest Ophthalmol Vis Sci. 2006 Mar;47(3):777-85
16505007
Exp Eye Res. 2001 Mar;72(3):311-8
11180980
Eur J Biochem. 1991 May 23;198(1):141-50
2040276
Anat Rec. 1970 Sep;168(1):105-25
5469558
EMBO J. 2004 Jan 14;23(1):89-99
14685281
Invest Ophthalmol Vis Sci. 1987 Mar;28(3):500-5
3557863
Dev Biol. 2008 Jan 15;313(2):752-66
18089288
Trans Am Ophthalmol Soc. 1930;28:195-211
16692859
J Biol Chem. 2006 Dec 22;281(51):39620-9
17023412
Mol Vis. 2004 Apr 02;10:254-9
15073582
Brain Res Dev Brain Res. 1999 May 14;114(2):171-8
10320756
J Physiol. 1969 Mar;201(1):21-47
5775812
EMBO J. 2003 Jan 15;22(2):236-45
12514129
Biomaterials. 2006 Mar;27(8):1670-8
16199085
Mol Biol Cell. 2007 Nov;18(11):4222-31
17699594
Dev Biol. 2007 Jun 15;306(2):658-68
17493607
Exp Eye Res. 2000 Dec;71(6):591-7
11095911
Invest Ophthalmol Vis Sci. 1997 Feb;38(2):396-404
9040473
Exp Eye Res. 2005 Jan;80(1):31-6
15652523
Biochem J. 1993 Dec 1;296 ( Pt 2):489-96
8257442
Nephrol Dial Transplant. 1997 Aug;12(8):1595-9
9269635
J Histochem Cytochem. 2003 Mar;51(3):285-96
12588956
Invest Ophthalmol Vis Sci. 2003 Feb;44(2):691-6
12556400
Differentiation. 1984;28(1):53-61
6394411
J Mol Biol. 1986 May 5;189(1):205-16
2946868
Respir Res. 2001;2(1):10-9
11686860
Matrix Biol. 1995 Feb;14(6):439-45
7795882
Mol Cell Biol. 2005 Aug;25(15):6846-56
16024816
Invest Ophthalmol Vis Sci. 1983 Apr;24(4):396-402
6601087
J Histochem Cytochem. 2003 Apr;51(4):503-11
12642629
Dev Biol. 1979 Apr;69(2):589-600
437354
Jpn J Ophthalmol. 2001 Jan-Feb;45(1):103-4
11163053
J Cell Sci. 2000 Sep;113 ( Pt 18):3173-85
10954416
Br J Ophthalmol. 2008 Mar;92(3):348-50
18211940
J AAPOS. 2006 Apr;10(2):182-3
16678759
Mol Cell Biol. 2000 Sep;20(18):7007-12
10958695
EMBO J. 1998 Aug 3;17(15):4213-25
9687490
Z Mikrosk Anat Forsch. 1989;103(6):971-84
2626867
Ophthalmic Genet. 1997 Sep;18(3):119-28
9361309
Z Zellforsch Mikrosk Anat. 1970;107(2):199-209
5447673
J Biomech Eng. 2007 Feb;129(1):121-5
17227107
WormBook. 2005 Sep 01;:1-15
18050423
Am J Anat. 1988 Nov;183(3):212-25
3213827
Physiol Rev. 2005 Jul;85(3):979-1000
15987800
J Invest Dermatol. 1982 Jul;79 Suppl 1:65s-68s
7045246
Exp Eye Res. 1999 Dec;69(6):603-10
10620389
Ophthalmic Res. 2005 May-Jun;37(3):156-8
15925909
Histol Histopathol. 1992 Apr;7(2):231-6
1515706
J Exp Med. 1975 Jun 1;141(6):1238-48
1092795
Invest Ophthalmol Vis Sci. 2008 Oct;49(10):4490-6
18515568
Acta Ophthalmol (Copenh). 1974;52(5):688-706
4138136
J Cell Biol. 1982 Oct;95(1):333-9
7142291