Pituitary autoimmunity: 30 years later.
Pituitary autoimmunity encompasses a spectrum of conditions ranging from histologically proven forms of lymphocytic hypophysitis to the presence of pituitary antibodies in apparently healthy subjects. Hypophysitis is a rare but increasingly recognized disorder that typically presents as a mass in the sella turcica. It mimics clinically and radiologically other non-functioning sellar masses, such as the more common pituitary adenoma. Hypophysitis shows a striking temporal association with pregnancy, and it has been recently described during immunotherapies that block CTLA-4. Several candidate pituitary autoantigens have been described in the last decade, although none has proven useful as a diagnostic tool. This review summarizes the advances made in the field since the publication of the first review on pituitary autoimmunity, and the challenges that await clarification.
Caturegli
Patrizio
P
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States. pcat@jhmi.edu
Lupi
Isabella
I
Landek-Salgado
Melissa
M
Kimura
Hiroaki
H
Rose
Noel R
NR
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D010900:Pituitary Diseases / Q000276:immunology*; D010902:Pituitary Gland / Q000276:immunology*; D010907:Pituitary Hormones / Q000276:immunology
D010907:Pituitary Hormones
J Clin Endocrinol Metab. 2006 Jul;91(7):2484-9
16621907
Eur J Clin Invest. 2005 Feb;35(2):126-32
15667584
Exp Clin Endocrinol Diabetes. 2004 May;112(5):231-5
15146367
J Endocrinol. 1998 Jun;157(3):475-80
9691980
J Clin Endocrinol Metab. 2002 Sep;87(9):4137-41
12213861
Diabetes Res. 1986 Mar;3(3):111-4
3011344
Clin Endocrinol (Oxf). 1993 May;38(5):495-500
8080469
Clin Endocrinol (Oxf). 2008 Aug;69(2):269-78
18194487
Diabetes Res. 1987 Feb;4(2):63-6
3034474
Clin Endocrinol (Oxf). 1994 Jun;40(6):809-10
8033375
Endocr J. 2003 Dec;50(6):697-702
14709840
Ann N Y Acad Sci. 2007 Jun;1107:129-35
17804540
Endocrine. 2003 Dec;22(3):335-40
14709807
Acta Biomed. 2007;78 Suppl 1:248-54
17465338
Endocr J. 2006 Oct;53(5):593-601
16896268
J Clin Endocrinol Metab. 1998 Feb;83(2):609-18
9467582
Clin Endocrinol (Oxf). 1986 Oct;25(4):411-20
3497738
Arch Intern Med. 1980 Sep;140(9):1243-5
6250507
Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):949-54
17215373
Endocr J. 2000 Aug;47(4):407-16
11075721
J Lab Clin Med. 1998 Jul;132(1):25-31
9665368
Ann Intern Med. 1986 Aug;105(2):200-3
3014939
J Neurosurg. 2004 Aug;101(2):262-71
15309917
Endocrinol Jpn. 1991 Apr;38(2):121-9
1661231
J Clin Endocrinol Metab. 2007 Jun;92(6):2176-81
17341554
Clin Endocrinol (Oxf). 2001 Mar;54(3):327-33
11298084
Eur J Endocrinol. 2008 Feb;158(2):147-52
18230820
J Clin Endocrinol Metab. 2007 Feb;92(2):604-7
17090639
Horm Res. 2001;55(6):288-92
11805433
J Endocrinol. 2002 Nov;175(2):417-23
12429039
Lancet. 1982 Apr 3;1(8275):755-9
6121222
J Clin Endocrinol Metab. 2003 Feb;88(2):650-4
12574195
Lancet. 1975 Jul 19;2(7925):97-101
49739
Clin Endocrinol (Oxf). 2008 Aug;69(2):285-91
18221394
Eur J Endocrinol. 2002 Dec;147(6):767-75
12457452
J Immunol Methods. 1993 Jun 4;162(1):31-40
8509651
Autoimmunity. 2003 May;36(3):155-9
12911282
J Clin Endocrinol Metab. 1988 Oct;67(4):633-8
3417843
Diabetes Care. 1997 May;20(5):864-6
9135957