Antidepressant behavioral effects of duloxetine and amitriptyline in the rat forced swimming test.
OBJECTIVE
To compare the effects of the antidepressant drugs duloxetine and amitriptyline on depressive behaviors in rats.


METHODS
Fifteen male Wistar rats were given systemic injections of duloxetine, amitriptyline or saline prior to a Forced Swimming Test (FST). Immobility and number of stops were measured. Data were analyzed by one-way ANOVA and Kruskall-Wallis.


RESULTS
Rats given injections of duloxetine displayed fewer stops than the amitriptyline and control group (p< 0.05). The control group and Amitriptyline showed no difference (p=0.8).


CONCLUSIONS
Duloxetine reduced depressive behaviors in the Forced Swimming Test been more effective than amitriptyline.
Menezes
Honório Sampaio
HS
IC, Cardiology University Foundation, Porto Alegre, Brazil. hsmenezes@computech.com.br
Bueno
Bárbara Beatriz Moreira
BB
Ciulla
Leandro
L
Schuh
Alexandre
A
Luz
Fernanda de Freitas
Fde F
Alves
Rafael José Vargas
RJ
Abegg
Milena Pacheco
MP
Cirino
Sílvia Letícia Merceo Bacchi
SL
D000639:Amitriptyline / Q000627:therapeutic use*; D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003863:Depression / Q000188:drug therapy* / Q000523:psychology; D004195:Disease Models, Animal; D000068736:Duloxetine Hydrochloride; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013550:Swimming / Q000523:psychology*; D013876:Thiophenes / Q000627:therapeutic use*
D000928:Antidepressive Agents; D013876:Thiophenes; D000639:Amitriptyline; D000068736:Duloxetine Hydrochloride