title: Antigen-presentation properties of plasmacytoid dendritic cells.
abstract: One of the remaining enigmas of the dendritic cell (DC) network is the potential contribution of plasmacytoid DCs (pDCs) to antigen presentation. Although the antigen-presentation capacity of conventional DCs (cDCs) is clearly defined, pDCs are generally attributed as having little, if any, antigen-presentation function. Instead, pDCs are regarded as immunomodulating cells, capable of directing the immune response through their secretion of large amounts of type I interferons. In this review, we examine the evidence for a potential role of pDC in antigen capture, processing, and presentation to T cells at sites of infection and in the lymph nodes.
authors.affiliation: The Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville, Victoria 3010, Australia.
authors.forename: José A
authors.initials: JA
authors.lastname: Villadangos
authors.forename: Louise
authors.initials: L
authors.lastname: Young
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D002465:Cell Movement; D045142:Cross-Priming; D003713:Dendritic Cells / Q000276:immunology* / Q000502:physiology; D006801:Humans; D007239:Infections / Q000276:immunology*; D008198:Lymph Nodes / Q000276:immunology; D008213:Lymphocyte Activation; D008285:Major Histocompatibility Complex / Q000276:immunology*; D010455:Peptides / Q000276:immunology / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
chemical_list: D010455:Peptides