[Relapse in acute promyelocytic leukemia and the role of hematopoietic stem cell transplantation in the treatment of APL].
The authors focused on relapses and transplantation treatment in APL. The incidence of relapses, their risk factors, and extramedullary relapses are reviewed. Considering treatment of relapses in APL, arsenic trioxide is now the standard treatment of APL relapse, however, treatment with gentuzumab ozogamicin should be considered when only a molecular relapse is detected. The following part of the issue is focused on the current status of hematopoietic stem cell transplantation in APL and on indications of transplantations from a modern APL therapy point of view.
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II interní klinika--oddelení klinické hematologie, Lékarská fakulta v Hradci Králové, Univerzita Karlova v Praze. zakpavel@fnhk.cz
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D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy / Q000628:therapy*; D012008:Recurrence; D012074:Remission Induction