Caspase cleavage is not for everyone.
During apoptosis, caspases cleave cellular substrates to break down and package the apoptotic cell for removal. Reporting in Cell, Mahrus et al. (2008) and Dix et al. (2008) use new approaches that identify hundreds of previously unrecognized caspase substrates, many of which appear to produce polypeptide fragments with potentially new functional activities.
Johnson
Carrie E
CE
Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.
Kornbluth
Sally
S
D017209:Apoptosis; D020169:Caspases / Q000378:metabolism*; D006801:Humans; D019169:Jurkat Cells; D011506:Proteins / Q000032:analysis* / Q000378:metabolism*; D013379:Substrate Specificity
D011506:Proteins; D020169:Caspases