title: Delayed cytotoxic effects of methyl jasmonate and cis-jasmone induced apoptosis in prostate cancer cells.
abstract: Advanced prostate cancer cells are typically hormone independent, resistant to apoptosis and do not respond to chemotherapeutic agents. The ability of methyl jasmonate (MJ) and cis-jasmone (CJ) to inhibit growth in hormone independent prostate cancer cell lines, PC-3 and DU-145, was evaluated. CJ and MJ inhibited cell growth, induced cell cycle arrest and apoptosis. Detailed studies with the PC-3 cell line revealed that 2 mM CJ or MJ treatment resulted in caspase 3 activation and Tumor Necrosis Factor Receptor 1 (TNFR1) activation, all hallmarks of apoptosis. These phytochemicals could be useful in the management of advanced prostate cancer.
authors.affiliation: Cancer Research Center/Chemistry Department, University of Nevada, Las Vegas, Las Vegas, Nevada, USA. yeruvavenkatl@uams.edu
authors.forename: Laxmi
authors.initials: L
authors.lastname: Yeruva
authors.forename: Keon J
authors.initials: KJ
authors.lastname: Pierre
authors.forename: Madhavi
authors.initials: M
authors.lastname: Bathina
authors.forename: Abiodun
authors.initials: A
authors.lastname: Elegbede
authors.forename: Stephen W
authors.initials: SW
authors.lastname: Carper
mesh_terms: D000085:Acetates / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D017209:Apoptosis; D053148:Caspase 3 / Q000096:biosynthesis; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003517:Cyclopentanes / Q000494:pharmacology*; D006801:Humans; D008297:Male; D054883:Oxylipins / Q000494:pharmacology*; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000096:biosynthesis
chemical_list: D000085:Acetates; D000972:Antineoplastic Agents, Phytogenic; D003517:Cyclopentanes; D054883:Oxylipins; D047888:Receptors, Tumor Necrosis Factor, Type I; C072239:methyl jasmonate; D053148:Caspase 3; C086299:jasmone