title: Status of immune mediators in complex regional pain syndrome type I.
abstract: Complex regional pain syndrome type I (CRPS-I) can affect an extremity after minor trauma or operation. The pathogenesis of this syndrome is unclear. It has clinical signs of severe local inflammation as a result of an exaggerated inflammatory response, but neurogenic dysregulation is also a contributor. Several studies investigated the role of inflammatory mediators and cytokines thus far; however, the results are heterogeneous and vary between different settings. This review summarizes recent study results that show a clear underlying inflammatory response at the local site, where systemic responses seem to be inconsistent. An induction of CRPS-like symptoms by application of neuroinflammatory mediators was shown recently. Local inflammation is involved in the pathophysiology of CRPS-I. We must expand our knowledge of pathophysiologic mechanisms, and we are still far away from using inflammatory markers in diagnosis and follow-up of CRPS-I.
authors.affiliation: Berufsgenossenschaftliche Kliniken Bergmannsheil, Department of Surgery, Ruhr University Bochum, Buerkle-de-la-Camp-Pl.1, Bochum, Germany. christian.schinkel@ruhr-uni-bochum.de
authors.forename: Christian
authors.initials: C
authors.lastname: Schinkel
authors.forename: Martin H
authors.initials: MH
authors.lastname: Kirschner
mesh_terms: D000818:Animals; D006801:Humans; D007155:Immunologic Factors / Q000502:physiology*; D018836:Inflammation Mediators / Q000502:physiology*; D012019:Reflex Sympathetic Dystrophy / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology
chemical_list: D007155:Immunologic Factors; D018836:Inflammation Mediators
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