Decreased CXCL12 (SDF-1) plasma levels in early Alzheimer's disease: a contribution to a deficient hematopoietic brain support?
The chemokine CXCL12 (also known as stromal cell-derived factor 1, SDF-1) controls many aspects of bone marrow-derived stem cell functions and has been associated with neurogenesis as well with recruitment of brain resident and non-resident circulating cells towards sites of lesion in the central nervous system (CNS). Disrupting this line of chemokine-mediated intercellular communication may contribute to the pathogenesis of Alzheimer's disease (AD). In this study, decreased CXCL12 plasma levels in patients with early AD (p = 0.003) were found, which significantly inversely correlated with CSF tau protein levels (r = -0.373; p = 0.042) and positively with CXCL12 CSF levels (r = 0.429; p = 0.018) and with changes of cognitive functions over the time period of 15 months (r = 0.583; p = 0.009). Our findings indicate a lack of chemotactic activity in early AD and support the view of a deficient regenerative hematopoietic brain support in early AD with putative pathogenic and therapeutic relevance.
Laske
Christoph
C
Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany. christoph.laske@med.uni-tuebingen.de
Stellos
Konstantinos
K
Eschweiler
Gerhard W
GW
Leyhe
Thomas
T
Gawaz
Meinrad
M
D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000453:epidemiology; D001921:Brain / Q000378:metabolism*; D054377:Chemokine CXCL12 / Q000097:blood* / Q000134:cerebrospinal fluid*; D003072:Cognition Disorders / Q000175:diagnosis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016298:Hematopoietic Cell Growth Factors / Q000172:deficiency*; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D012720:Severity of Illness Index; D016875:tau Proteins / Q000097:blood
C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D016298:Hematopoietic Cell Growth Factors; D016875:tau Proteins