title: Acute phase protein response in goats.
abstract: Acute phase proteins (APPs) are important diagnostic indicators of inflammatory disturbances in animals. The objectives of the current study were to validate analytical methods for measuring haptoglobin (Hp), serum amyloid A (SAA), acid soluble glycoprotein (ASG), fibrinogen, and albumin concentrations in goats and to evaluate their response to an inflammatory stimulus in this species. Intra- and interassay coefficients of variation (CVs) were in the range 0.07-9.31% and 1.83-12.68%, respectively, for all APPs and showed good precision. All assays determined APPs in a linear manner at different sample dilutions with high correlation coefficients with the exception of fibrinogen, which was measured by the heat precipitation method. Subcutaneous injection of turpentine oil induced an increase in Hp, SAA, ASG, and fibrinogen serum concentrations and a decrease in albumin concentration.
authors.affiliation: Veterinary School, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
authors.forename: Félix H D
authors.initials: FH
authors.lastname: González
authors.forename: Fernando
authors.initials: F
authors.lastname: Tecles
authors.forename: Silvia
authors.initials: S
authors.lastname: Martínez-Subiela
authors.forename: Asta
authors.initials: A
authors.lastname: Tvarijonaviciute
authors.forename: Laura
authors.initials: L
authors.lastname: Soler
authors.forename: José J
authors.initials: JJ
authors.lastname: Cerón
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism*; D000818:Animals; D005340:Fibrinogen / Q000378:metabolism; D015511:Goat Diseases / Q000097:blood*; D006041:Goats; D006242:Haptoglobins / Q000378:metabolism; D007249:Inflammation / Q000097:blood / Q000662:veterinary*; D012680:Sensitivity and Specificity; D012709:Serum Albumin / Q000378:metabolism; D000685:Serum Amyloid A Protein / Q000378:metabolism
chemical_list: D000209:Acute-Phase Proteins; D006242:Haptoglobins; D012709:Serum Albumin; D000685:Serum Amyloid A Protein; D005340:Fibrinogen