title: Recent progress of SRC family kinase inhibitors as anticancer agents.
abstract: Src family of protein tyrosine kinases (SFKs) play key roles in regulating signal transduction in cellular processes. However, hyper-activated SFKs lead to uncontrolled cell proliferation and cancers. Many SFKs inhibitors were designed and synthesized as anticancer agents in the past several years and great progress has been made. Herein, some predominant examples of SFKs inhibitors recently developed are reviewed and special attentions are paid to the most important ATP binding site inhibitors.
authors.affiliation: Jiangsu Key Laboratory of Carcinogenesis and Intervention, Department of Medicinal Chemistry, China Pharmaceutical University, No. 24, Tongjiaxiang Rd, Nanjing 210009, Jiangsu Province, PR China.
authors.forename: Xin
authors.initials: X
authors.lastname: Cao
authors.forename: Qi-Dong
authors.initials: QD
authors.lastname: You
authors.forename: Zhi-Yu
authors.initials: ZY
authors.lastname: Li
authors.forename: Xiao-Jian
authors.initials: XJ
authors.lastname: Wang
authors.forename: Xiao-Yun
authors.initials: XY
authors.lastname: Lu
authors.forename: Xiao-Rong
authors.initials: XR
authors.lastname: Liu
authors.forename: Dan
authors.initials: D
authors.lastname: Xu
authors.forename: Bao
authors.initials: B
authors.lastname: Liu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D001665:Binding Sites / Q000187:drug effects; D015195:Drug Design; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D013329:Structure-Activity Relationship; D019061:src-Family Kinases / Q000037:antagonists & inhibitors*
chemical_list: D000970:Antineoplastic Agents; D019061:src-Family Kinases