[A case of advanced small cell lung cancer complicated by chronic renal failure treated with amrubicin].
A 64-year old man first visited our clinic approximately 10 years ago because of diabetic nephropathy that had developed into chronic renal failure. He was hospitalized to examine a left S10 tumor shadow. Based on the results of these examinations, a primary left S10 T2N0M1, ED small cell lung cancer, was diagnosed. During his outpatient visits nephropathy was found. Following admission, he began dialysis (HD). During the detailed examinations, chemotherapy with amrubicin (AMR)was performed and the blood concentration of the drug was measured. The results showed no significant variations in blood concentration before and after the dialysis. While PR was achieved in this patient, a reduction in grade 4 eosinophils was observed as an adverse reaction.
Isogai
Sumito
S
Dept. Internal Medicine, Division of Respirology Medicine and Clinical Allergy, School of Medicine, Fujita Health University.
Totani
Yoshitaka
Y
Kohashi
Yasuo
Y
Mieno
Yuuki
Y
Imizu
Hiromi
H
Yoneda
Yukiko
Y
Shimizu
Hideyasu
H
Hoshino
Tami
T
Uchiyama
Yasuhiro
Y
Takeuchi
Yasuo
Y
Hayashi
Masamichi
M
Saitoh
Yuji
Y
Sasaki
Fumihiko
F
Okazawa
Mitsushi
M
Sakakibara
Hiroki
H
D018943:Anthracyclines / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use*; D018288:Carcinoma, Small Cell / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D008175:Lung Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D014057:Tomography, X-Ray Computed
D018943:Anthracyclines; C055866:amrubicin