Development of biodegradable crosslinked urethane-doped polyester elastomers.
Traditional crosslinked polyester elastomers are inherently weak, and the strategy of increasing crosslink density to improve their mechanical properties makes them brittle materials. Biodegradable polyurethanes, although strong and elastic, do not fare well in dynamic environments due to the onset of permanent deformation. The design and development of a soft, strong and completely elastic (100% recovery from deformation) material for tissue engineering still remains a challenge. Herein, we report the synthesis and evaluation of a new class of biodegradable elastomers, crosslinked urethane-doped polyesters (CUPEs), which is able to satisfy the need for soft, strong, and elastic biomaterials. Tensile strength of CUPE was as high as 41.07+/-6.85 MPa with corresponding elongation at break of 222.66+/-27.84%. The initial modulus ranged from 4.14+/-1.71 MPa to 38.35+/-4.5 MPa. Mechanical properties and degradation rates of CUPE could be controlled by varying the choice of diol used for synthesis, the polymerization conditions, as well as the concentration of urethane bonds in the polymer. The polymers demonstrated good in vitro and in vivo biocompatibilities. Preliminary hemocompatibility evaluation indicated that CUPE adhered and activated lesser number of platelets compared to PLLA. Good mechanical properties and easy processability make these materials well suited for soft tissue engineering applications. The introduction of CUPEs provides new avenues to meet the versatile requirements of tissue engineering and other biomedical applications.
Dey
Jagannath
J
Department of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA.
Xu
Hao
H
Shen
Jinhui
J
Thevenot
Paul
P
Gondi
Sudershan R
SR
Nguyen
Kytai T
KT
Sumerlin
Brent S
BS
Tang
Liping
L
Yang
Jian
J
D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D020724:Elastomers / Q000737:chemistry; D005260:Female; D006801:Humans; D051379:Mice; D041681:NIH 3T3 Cells; D011091:Polyesters / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D014520:Urethane / Q000737:chemistry
D001672:Biocompatible Materials; D020724:Elastomers; D011091:Polyesters; D014520:Urethane
J Biomater Sci Polym Ed. 2001;12(8):851-73
11718481
Biomaterials. 2004 Jan;25(1):177-87
14580921
Biomaterials. 2005 Jun;26(18):3961-71
15626443
J Mater Sci Mater Med. 2003 Sep;14(9):767-73
15348396
Biomacromolecules. 2005 Sep-Oct;6(5):2833-42
16153125
Tissue Eng. 2005 Sep-Oct;11(9-10):1562-73
16259610
Tissue Eng. 2005 Nov-Dec;11(11-12):1876-86
16411834
J Cell Biol. 1979 Oct;83(1):126-42
511936
Biomaterials. 2006 Aug;27(24):4315-24
16675010
J Appl Physiol (1985). 2005 Jun;98(6):2321-7
15894540
Arterioscler Thromb Vasc Biol. 2005 Jun;25(6):1128-34
15705929
Circ Res. 2006 Jan 6;98(1):25-35
16397155
Circulation. 2006 Feb 28;113(8):1108-13
16490815
Nat Biotechnol. 2002 Jun;20(6):602-6
12042865
Ann N Y Acad Sci. 2002 Jun;961:251-4
12081910
Biomaterials. 2007 Dec;28(36):5407-17
17915310
J Biomed Mater Res B Appl Biomater. 2005 Jul;74(1):570-81
15889440
Matrix Biol. 2000 Aug;19(4):353-7
10963996
Biomaterials. 2005 Dec;26(35):7377-86
16023195
J Biomater Sci Polym Ed. 1998;9(3):271-95
9556762
Biomaterials. 2003 Dec;24(28):5163-71
14568433
Biomaterials. 2008 May;29(15):2315-25
18295329
Biomaterials. 2006 Mar;27(9):1889-98
16290904
J Biomech. 1992 Aug;25(8):925-7
1639836
Biomaterials. 2004 Oct;25(22):5261-9
15110477
Biomaterials. 2004 Nov;25(26):5681-703
15147815
Trends Cell Biol. 1998 Nov;8(11):437-41
9854310
FASEB J. 2006 May;20(7):811-27
16675838
Biotechnology (N Y). 1995 Feb;13(2):142-50
9634754
Biomaterials. 2004 Jan;25(1):85-96
14580912
J Biomed Mater Res A. 2003 Dec 1;67(3):876-85
14613236
Biomaterials. 2001 Nov;22(21):2849-55
11561890
Biomaterials. 2005 Sep;26(27):5454-64
15860202
J Biomed Mater Res. 2002 Sep 5;61(3):493-503
12115475
Biomacromolecules. 2004 Jul-Aug;5(4):1399-404
15244457
Tissue Eng. 2006 Jul;12(7):1945-53
16889524
J Clin Invest. 1986 Jul;78(1):130-7
2941452
J Biomed Mater Res A. 2007 Sep 15;82(4):907-16
17335023
Biomaterials. 2004 Aug;25(19):4749-57
15120521
J Bone Joint Surg Am. 1976 Dec;58(8):1074-82
1002748
J Biomed Mater Res. 2002 Dec 5;62(3):438-46
12209930
J Biomater Sci Polym Ed. 2001;12(1):35-53
11334188
J Biomed Mater Res. 1999 Oct;47(1):8-17
10400875