Update on pancreatic intraepithelial neoplasia.
Pancreatic intraepithelial neoplasia (PanIN) is a histologically well-defined precursor to invasive ductal adenocarcinoma of the pancreas. PanINs are remarkably common lesions, particularly in the elderly population. Molecular studies have helped establish the progression of PanIN to invasive cancer, and recently genetically engineered mouse models have been generated that recapitulate the entire spectrum of lesions from precursor to invasive pancreatic cancer. Some PanIN lesions produce lobulocentric atrophy of the pancreatic parenchyma, and, when multifocal, this lobulocentric atrophy may be detectable using currently available imaging techniques such as endoscopic ultrasound. The association of acinar-ductal metaplasia with PanIN lesions has led some to hypothesize that PanINs develop from acinar cells that undergo acinar-ductal metaplasia.
Hruban
Ralph H
RH
The Sol Goldman Pancreatic Cancer Research Center, the Departments of Pathology and Oncology, Johns Hopkins Medical Institutions, Baltimore, MD, USA. rhruban@jhmi.edu
Maitra
Anirban
A
Goggins
Michael
M
Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4437-42
17360542
Mod Pathol. 2003 Sep;16(9):902-12
13679454
Cancer Res. 1993 Mar 1;53(5):953-6
8439969
Neoplasia. 2005 Jan;7(1):17-23
15720814
Genes Dev. 2006 Nov 15;20(22):3130-46
17114584
Am J Pathol. 2002 Nov;161(5):1541-7
12414502
Gastroenterology. 2002 Oct;123(4):1052-60
12360467
Cancer Cell. 2007 Mar;11(3):211-3
17349578
Am J Surg Pathol. 1998 Feb;22(2):163-9
9500216
Mol Imaging. 2007 Mar-Apr;6(2):131-9
17445507
Mod Pathol. 2003 Oct;16(10):996-1006
14559982
Clin Gastroenterol Hepatol. 2004 Jul;2(7):606-21
15224285
Am J Pathol. 2000 Jul;157(1):83-92
10880379
Nat Genet. 1994 Sep;8(1):27-32
7726912
Mol Cell Biol. 2002 Jan;22(2):635-43
11756558
Cancer Res. 2006 Jan 15;66(2):1208-17
16424060
Cancer. 1979 Apr;43(4):1418-28
445339
Am J Surg Pathol. 2001 May;25(5):579-86
11342768
Gastroenterology. 2006 Dec;131(6):1844-55
17087933
Cancer Res. 2004 Apr 1;64(7):2634-8
15059921
Clin Gastroenterol Hepatol. 2006 Jun;4(6):766-81; quiz 665
16682259
Am J Surg Pathol. 2004 Aug;28(8):977-87
15252303
Am J Pathol. 2000 Jun;156(6):2123-33
10854233
Cancer Res. 1997 Jun 1;57(11):2140-3
9187111
Cancer Cell. 2005 May;7(5):469-83
15894267
Am J Clin Pathol. 2002 May;117(5):791-6
12090430
Am J Pathol. 2000 May;156(5):1767-71
10793087
JAMA. 2000 Oct 18;284(15):1954-61
11035892
Cancer Res. 2003 Jul 1;63(13):3735-42
12839967
Am J Pathol. 2001 May;158(5):1677-83
11337365
Am J Surg Pathol. 2006 Sep;30(9):1067-76
16931950
Cancer Res. 2000 Apr 1;60(7):1835-9
10766168
Cancer Res. 2007 Jan 15;67(2):433-6
17234748
Cancer Res. 1994 Jul 1;54(13):3568-73
8012983
Nat Methods. 2004 Nov;1(2):141-7
15782177
Virchows Arch. 2005 Nov;447(5):800-5
16021508
Cancer Res. 2005 Mar 1;65(5):1619-26
15753353
Am J Surg Pathol. 2001 Aug;25(8):1047-53
11474289
Cancer Cell. 2007 Mar;11(3):291-302
17349585
Am J Pathol. 2002 May;160(5):1573-81
12000709
Cancer Cell. 2007 Mar;11(3):229-43
17349581
J Hepatobiliary Pancreat Surg. 2006;13(4):286-95
16858539
Clin Cancer Res. 2006 Sep 15;12(18):5411-6
17000674
Clin Cancer Res. 2006 Sep 15;12(18):5417-22
17000675
Cancer Cell. 2005 Sep;8(3):185-95
16169464
Cancer. 1999 Apr 15;85(8):1703-10
10223563
Gastroenterology. 2004 Jun;126(7):1674-80
15188160
Science. 1996 Jan 19;271(5247):350-3
8553070
Cancer Res. 1998 Oct 15;58(20):4740-4
9788631
Cancer Res. 2006 Jan 1;66(1):242-7
16397237
Cancer Res. 1976 Jul;36(7 PT 2):2690-8
1277176
J Natl Cancer Inst. 2003 Apr 16;95(8):622-5
12697855
Am J Surg Pathol. 2006 Jun;30(6):754-9
16723855
Cancer Epidemiol Biomarkers Prev. 1998 Jun;7(6):515-21
9641496
Pancreas. 2003 Apr;26(3):e48-54
12657964
Am J Surg Pathol. 2003 Dec;27(12):1495-501
14657708
Mod Pathol. 2002 Oct;15(10):1087-95
12379756
Am J Clin Pathol. 2002 Aug;118(2):194-201
12162677
Ann Diagn Pathol. 1998 Oct;2(5):286-92
9845751
J Natl Cancer Inst. 1997 Mar 19;89(6):442-6
9091646
Genes Dev. 2003 Dec 15;17(24):3112-26
14681207
Cancer Biol Ther. 2002 May-Jun;1(3):293-6
12432281
Cancer Biol Ther. 2003 Jan-Feb;2(1):78-83
12673124
J Hepatobiliary Pancreat Surg. 2007;14(3):243-54
17520199
Cancer Res. 2006 Jan 1;66(1):95-106
16397221
Cancer Res. 2007 Aug 1;67(15):7068-71
17652141
N Engl J Med. 2005 Oct 27;353(17):1784-92
16251534
Gastroenterology. 1996 Jan;110(1):227-31
8536861
Cancer Cell. 2003 Dec;4(6):437-50
14706336
Cancer Res. 2003 May 1;63(9):2005-9
12727809
Am J Pathol. 2007 Jul;171(1):263-73
17591971
Clin Cancer Res. 2000 Aug;6(8):2969-72
10955772
Cancer Res. 2000 Apr 1;60(7):2002-6
10766191
Cancer Res. 1997 Aug 1;57(15):3126-30
9242437
Am J Surg Pathol. 2007 Apr;31(4):645-6
17414117
Int J Cancer. 2006 Jan 15;118(2):405-11
16052519
Ann Intern Med. 1999 Aug 17;131(4):247-55
10454945