Synthesis and immunostimulatory properties of the phosphorothioate analogues of cdiGMP.
The synthesis of mono- and bisphosphorothioate analogues of 3',5'-cyclic diguanylic acid (cdiGMP) via the modified H-phosphonate chemistry is reported. The immunostimulatory properties of these analogues were compared with those of cdiGMP.
Yan
Hongbin
H
Department of Chemistry, Brock University, 500 Glenridge Avenue, St. Catharines, Ont., Canada L2S 3A1. tyan@brocku.ca
Wang
Xiaolu
X
KuoLee
Rhonda
R
Chen
Wangxue
W
D001980:Bronchi / Q000378:metabolism; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D006152:Cyclic GMP / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D006801:Humans; D007107:Immune System; D007249:Inflammation; D008956:Models, Chemical; D009504:Neutrophils / Q000378:metabolism; D063065:Organophosphonates / Q000737:chemistry; D010710:Phosphates / Q000737:chemistry*; D014612:Vaccines / Q000737:chemistry
D063065:Organophosphonates; D010710:Phosphates; D014612:Vaccines; C062025:bis(3',5')-cyclic diguanylic acid; D006152:Cyclic GMP; C035638:thiophosphoric acid