Circulating levels of lectin-like oxidized low-density lipoprotein receptor-1 are associated with inflammatory markers.
Lectin-like oxidized-low-density lipoprotein receptor-1 (LOX-1) is increasingly linked to atherosclerotic plaque formation and the soluble form of this receptor may reflect activities of disease. We investigated the associations among levels of sLOX-1, oxidized-low-density lipoprotein (ox-LDL), cytokines and the extension of atherosclerosis in patients with coronary artery disease (CAD). Lipid, TNF-alpha, IL-6, C reactive protein (CRP), ox-LDL, peroxy radical and sLOX-1 levels were measured in 29 controls and 60 patients with CAD, 30 of which with one or two vessels involved (group 1), and 30 patients with three or four vessels involved (group 2). The serum levels of sLOX-1 were significantly and progressively higher in group 1 [611 (346-1,313) pg/ml, median (interquartile range)] and in group 2 [2,143 (824-3,201) pg/ml] than in control subjects [268 (111-767) pg/ml]. LOX-1 levels positively correlated with IL-6 (r = 0.38, P = 0.0042), TNF-alpha (r = 0.38, P = 0.0037), CRP levels (r = 0.32, P = 0.027) and age (r = 0.25, P = 0.048). In the multivariate analysis TNF-alpha resulted the only independent determinant of LOX-1 serum levels (beta-value = 0.304, P = 0.017). These findings suggest that sLOX-1 levels are up-regulated during CAD progression and are associated with inflammatory markers. The measurement of the circulating soluble form of this receptor may be potentially useful in predicting CAD progression in humans.
Lubrano
Valter
V
Institute of Clinical Physiology CNR and G. Monasterio foundation, Via Moruzzi, 1, 56124, Pisa, Italy.
Del Turco
Serena
S
Nicolini
Giuseppina
G
Di Cecco
Pietro
P
Basta
Giuseppina
G
D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D003324:Coronary Artery Disease / Q000097:blood*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008055:Lipids / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D051127:Scavenger Receptors, Class E / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
D015415:Biomarkers; D015850:Interleukin-6; D008055:Lipids; D008077:Lipoproteins, LDL; D051127:Scavenger Receptors, Class E; D014409:Tumor Necrosis Factor-alpha; C099252:oxidized low density lipoprotein; D002097:C-Reactive Protein
Circulation. 1996 Mar 15;93(6):1107-13
8653830
Circ Res. 1998 Aug 10;83(3):322-7
9710125
Int J Cardiol. 2009 May 15;134(2):285-7
18367271
Arterioscler Thromb Vasc Biol. 2001 Apr;21(4):560-6
11304473
Biochem J. 1998 Aug 15;334 ( Pt 1):9-13
9693095
Biochem J. 2008 Jan 15;409(2):349-55
18092947
Circ Res. 2005 Jul 22;97(2):176-84
15961718
Arterioscler Thromb Vasc Biol. 2000 Mar;20(3):715-20
10712396
Circulation. 2005 Aug 9;112(6):812-8
16061745
J Biol Chem. 2002 Nov 29;277(48):45898-903
12270921
J Lipid Res. 2008 Jul;49(7):1438-44
18408244
Circ Res. 2004 Oct 29;95(9):877-83
15472120
J Biol Chem. 2001 Mar 2;276(9):6343-9
11102451
J Clin Invest. 1995 Mar;95(3):1262-70
7533787
Circulation. 1994 Jan;89(1):36-44
8281670
FEBS Lett. 1998 Nov 27;440(1-2):29-32
9862418
Cytokine Growth Factor Rev. 1996 Oct;7(3):231-40
8971478
Nature. 1997 Mar 6;386(6620):73-7
9052782
Circ Res. 2007 Jun 8;100(11):1634-42
17478727