Role of copper in human neurological disorders.
Copper is a trace element present in all tissues and is required for cellular respiration, peptide amidation, neurotransmitter biosynthesis, pigment formation, and connective tissue strength. Copper is a cofactor for numerous enzymes and plays an important role in central nervous system development; low concentrations of copper may result in incomplete development, whereas excess copper maybe injurious. Copper may be involved in free radical production, via the Haber-Weiss reaction, that results in mitochondrial damage, DNA breakage, and neuronal injury. Evidence of abnormal copper transport and aberrant copper-protein interactions in numerous human neurological disorders supports the critical importance of this trace metal for proper neurodevelopment and neurological function. The biochemical phenotypes of human disorders that involve copper homeostasis suggest possible biomarkers of copper status that may be applicable to general populations.
Desai
Vishal
V
Unit on Pediatric Genetics, Program in Molecular Medicine, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Kaler
Stephen G
SG
D000544:Alzheimer Disease / Q000378:metabolism; D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism; D003300:Copper / Q000378:metabolism*; D004247:DNA / Q000378:metabolism; D005341:Fibrinolysin / Q000172:deficiency; D006801:Humans; D006816:Huntington Disease / Q000378:metabolism; D009422:Nervous System Diseases / Q000235:genetics / Q000378:metabolism*; D010300:Parkinson Disease / Q000378:metabolism; D017096:Prion Diseases / Q000378:metabolism
D003300:Copper; D004247:DNA; D005341:Fibrinolysin