title: [The effect of basic fibroblast growth factor on the gene expression of decorin by periodontal ligament fibroblasts in culture].
abstract: OBJECTIVE
  To study the effect of basic fibroblast growth factor (bFGF) on the gene expression of decorin by periodontal ligament fibroblasts (PLFs) in culture, and discuss the effect of bFGF in periodontal regeneration.
  
  
  METHODS
  Human PLFs were cultured and stimulated by exogenous bFGF. Gene expression of decorin was assessed by semi-quantitive RT-PCR.
  
  
  RESULTS
  The mRNA expression of decorin was suppressed by bFGF and the effect was dose-dependent. When the dose of bFGF increased, the inhibitive effect decreased.
  
  
  CONCLUSIONS
  Decorin has many biological effects. The inhibitive effect may be one of important factors which participate in the healing process of periodontitis, and provide partly theoretical basis of bFGF in periodontal regeneration.
authors.affiliation: Dept. of Periodontology, Stomatology Hospital of Jilin University, Changchun 130041, China.
authors.forename: Si-cong
authors.initials: SC
authors.lastname: Wang
authors.forename: Chong-tao
authors.initials: CT
authors.lastname: Lin
authors.forename: Dai-bang
authors.initials: DB
authors.lastname: Nie
authors.forename: Hong-sheng
authors.initials: HS
authors.lastname: Ouyang
mesh_terms: D058575:Decorin; D016222:Fibroblast Growth Factor 2; D005347:Fibroblasts; D006801:Humans; D010513:Periodontal Ligament; D012333:RNA, Messenger; D012038:Regeneration
chemical_list: C546878:DCN protein, human; D058575:Decorin; D012333:RNA, Messenger; D016222:Fibroblast Growth Factor 2