The association of C (-260)-->T polymorphism in CD14 promoter and Chlamydia pneumoniae infection in ischemic stroke patients.
The C (-260) --> T polymorphism has been reported to regulate CD14 gene expression. It has also been implicated in atherosclerotic diseases, and in addition, it could be a genetic factor responsible for interindividual differences in the susceptibility to Chlamydia pneumoniae infection. This case-control study is aimed at evaluating the association between CD14 promoter polymorphisms, frequency of persistent C pneumoniae infection, and anti-chlamydial heat shock protein 60 (cHsp60) induction in stroke patients. Persistent C pneumoniae infection was observed in 43.3% of control subjects and 53.3% of patients (P = .005). The odds ratio of persistent infection was 3.25 for the CC genotype in stroke patients (P = .018). However, the serologic positive responses to cHsp60 in people with the TT genotype were significantly lower in stroke patients (9.3% vs 38.6%; P < .001). Our findings suggest that persistent C pneumoniae infection is independently associated with stroke in CC genotypes and the lowering of cHsp60 antibody levels in TT genotypes.
Lin
Tsun-Mei
TM
Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, Tainan, Taiwan.
Chen
Chih-Hung
CH
Wu
Hua-Lin
HL
Wang
Chiou-Huey
CH
Chen
Yi-Ling
YL
Eng
Hock-Liew
HL
D000368:Aged; D016022:Case-Control Studies; D018834:Chaperonin 60 / Q000097:blood; D023521:Chlamydophila Infections / Q000150:complications* / Q000235:genetics* / Q000276:immunology; D016993:Chlamydophila pneumoniae / Q000276:immunology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D020521:Stroke / Q000150:complications* / Q000209:etiology / Q000235:genetics* / Q000276:immunology
D018834:Chaperonin 60; D018950:Lipopolysaccharide Receptors