title: High expression of vanilloid receptor-1 is associated with better prognosis of patients with hepatocellular carcinoma.
abstract: The vanilloid receptor-1 (VR1) is a ligand-gated, nonselective cation channel expressed predominantly by sensory neurons, but is also involved in carcinogenesis. To elucidate its role in hepatocarcinogenesis, we analyzed the expression of VR1 receptor in tumor and nontumor tissues from human hepatocellular carcinoma (HCC) samples. In situ hybridization analysis showed overexpression of VR1 mRNAs in 9/15 (60.0%) noncancer and 6/15 (40.0%) HCC samples. Immunohistochemistry of 62 HCC samples showed the expression of VR1 increased from normal liver or chronic hepatitis to cirrhosis. Marked expression of VR1 was noted in the majority [31/38 (81.6%)] of cirrhotic liver samples. In HCC, high expression of VR1 was observed in 30/62 (48.4%) cases. Clinicopathologic evaluation indicated a significant correlation between VR1 expression and histopathologic differentiation (P=0.001). Univariate analysis indicated that disease-free survival was significantly better in HCC patients with high versus those with low VR1 expression levels (P= 0.021). Our results indicate that VR1 has anti-HCC progression effects and can be potentially used as a prognostic indicator of HCC. The results suggest the potential beneficiary effects of VR1 expression on the prognosis of patients with HCC.
authors.affiliation: Department of Surgery, Xiangya 2nd Hospital, Central South University, Renmin Zhong Road 139, Changsha City, Hunan Province, China.
authors.forename: Xiongying
authors.initials: X
authors.lastname: Miao
authors.forename: Guoxing
authors.initials: G
authors.lastname: Liu
authors.forename: Xundi
authors.initials: X
authors.lastname: Xu
authors.forename: Chengzhi
authors.initials: C
authors.lastname: Xie
authors.forename: Fadi
authors.initials: F
authors.lastname: Sun
authors.forename: Yaohui
authors.initials: Y
authors.lastname: Yang
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.forename: Songwen
authors.initials: S
authors.lastname: Hua
authors.forename: Wentao
authors.initials: W
authors.lastname: Fan
authors.forename: Qinglong
authors.initials: Q
authors.lastname: Li
authors.forename: Shengfu
authors.initials: S
authors.lastname: Huang
authors.forename: Qunwei
authors.initials: Q
authors.lastname: Wang
authors.forename: Guoli
authors.initials: G
authors.lastname: Liu
authors.forename: Dewu
authors.initials: D
authors.lastname: Zhong
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D002454:Cell Differentiation / Q000235:genetics; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D019694:Hepatitis B, Chronic / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D006801:Humans; D017403:In Situ Hybridization; D008103:Liver Cirrhosis / Q000235:genetics / Q000378:metabolism; D008113:Liver Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics*; D011379:Prognosis; D012333:RNA, Messenger / Q000096:biosynthesis; D012334:RNA, Neoplasm / Q000096:biosynthesis; D016037:Single-Blind Method; D050916:TRPV Cation Channels / Q000096:biosynthesis / Q000235:genetics*
chemical_list: D009363:Neoplasm Proteins; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D050916:TRPV Cation Channels; C494484:TRPV1 receptor