[Expression and clinical significance of highly expressed protein in cancer (Hec 1) in human primary gallbladder carcinoma].
OBJECTIVE
To investigate the relationship between the expression of highly expressed protein in cancer (Hec 1) and infiltration, metastasis and prognosis of human primary gallbladder carcinoma (PGC).


METHODS
The expression of Hec 1 in was detected 108 patients with PGC by SABC immunohistochemistry with 15 cases of chronic cholecystitis as control. Then, a 5 year follow-up was carnedout in 96 out of 108 patients to analyze the correlation between Hec 1 and prognosis of the patients.


RESULTS
The clinical pathological characteristics of PGC and clinical outcome of the patients were associated with the expression of Hec 1. Hec 1 was highhy expressed in cancer tissues with lymph node metastasis and poor differentiation. Especially, a statistical correlation was found with more advanced Nevin stages of PGC (P < 0.05). Moreover, the 5-year survival rate of the patients with PGC whose expression of Hec 1 was positive was significantly lower than that of the patients without Hec 1 expression (P < 0.01).


CONCLUSIONS
Hec 1 may be associated with the development, infiltration and metastasis of PGC. The combination of Hec 1 expression in cancer tissues with clinical staging may faliliate the auurate predication of patients' prognosis.
Xiao
Guang-fa
GF
Department of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Tang
Hui-huan
HH
D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D003598:Cytoskeletal Proteins; D005260:Female; D005706:Gallbladder Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism; D011379:Prognosis
D003598:Cytoskeletal Proteins; C120529:NDC80 protein, human; D009687:Nuclear Proteins