title: The association of C (-260)-->T polymorphism in CD14 promoter and Chlamydia pneumoniae infection in ischemic stroke patients.
abstract: The C (-260) --> T polymorphism has been reported to regulate CD14 gene expression. It has also been implicated in atherosclerotic diseases, and in addition, it could be a genetic factor responsible for interindividual differences in the susceptibility to Chlamydia pneumoniae infection. This case-control study is aimed at evaluating the association between CD14 promoter polymorphisms, frequency of persistent C pneumoniae infection, and anti-chlamydial heat shock protein 60 (cHsp60) induction in stroke patients. Persistent C pneumoniae infection was observed in 43.3% of control subjects and 53.3% of patients (P = .005). The odds ratio of persistent infection was 3.25 for the CC genotype in stroke patients (P = .018). However, the serologic positive responses to cHsp60 in people with the TT genotype were significantly lower in stroke patients (9.3% vs 38.6%; P < .001). Our findings suggest that persistent C pneumoniae infection is independently associated with stroke in CC genotypes and the lowering of cHsp60 antibody levels in TT genotypes.
authors.affiliation: Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Tsun-Mei
authors.initials: TM
authors.lastname: Lin
authors.forename: Chih-Hung
authors.initials: CH
authors.lastname: Chen
authors.forename: Hua-Lin
authors.initials: HL
authors.lastname: Wu
authors.forename: Chiou-Huey
authors.initials: CH
authors.lastname: Wang
authors.forename: Yi-Ling
authors.initials: YL
authors.lastname: Chen
authors.forename: Hock-Liew
authors.initials: HL
authors.lastname: Eng
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D018834:Chaperonin 60 / Q000097:blood; D023521:Chlamydophila Infections / Q000150:complications* / Q000235:genetics* / Q000276:immunology; D016993:Chlamydophila pneumoniae / Q000276:immunology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D020521:Stroke / Q000150:complications* / Q000209:etiology / Q000235:genetics* / Q000276:immunology
chemical_list: D018834:Chaperonin 60; D018950:Lipopolysaccharide Receptors