title: Two-component signaling systems and cell cycle control in Caulobacter crescentus.
abstract: Recent work on the regulation ofprokaryotic growth and development by two-component systems (TCS) has revealed unsuspected levels of complexity. In the dimorphic freshwater bacterium Caulobacter crescentus, TCS provide stringent temporal and spatial control of cellular development and cell-cycle progression. While the environmental signals modulating TCS regulatory networks are largely unknown, the components of the network and their interactions with each other are increasingly well-defined. Here, we present an overview of TCS regulation of cell-cycle control in C. crescentus.
authors.affiliation: Department of Biochemistry and Molecular Biology, The University of Chicago, Gordon Center for Integrative Science, 929 E. 57th Street, Chicago, IL 60637, USA.
authors.forename: Erin B
authors.initials: EB
authors.lastname: Purcell
authors.forename: Cara C
authors.initials: CC
authors.lastname: Boutte
authors.forename: Sean
authors.initials: S
authors.lastname: Crosson
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology; D016935:Caulobacter crescentus / Q000166:cytology* / Q000235:genetics / Q000378:metabolism*; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000235:genetics / Q000502:physiology; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology; D005798:Genes, Bacterial; D000071677:Histidine Kinase; D008954:Models, Biological; D010447:Peptide Hydrolases / Q000378:metabolism; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology
chemical_list: D001426:Bacterial Proteins; D018797:Cell Cycle Proteins; C097706:CtrA protein, Caulobacter; D004268:DNA-Binding Proteins; C066312:DnaA protein, Bacteria; D014157:Transcription Factors; D011494:Protein Kinases; D000071677:Histidine Kinase; D010447:Peptide Hydrolases