title: Reclassification of patients for aggressive cholesterol treatment: additive value of multislice coronary angiography to the National Cholesterol Education Program guidelines.
abstract: BACKGROUND
  National Cholesterol Education Program (NCEP) guidelines have been used to define treatment goals in patients with hypercholesterolemia. However, epidemiology-based guidelines are unable to identify all subjects with coronary artery disease for aggressive lipid intervention.
  
  
  OBJECTIVE
  We sought to evaluate the additive value of multislice computed tomography (MSCT) angiography to the NCEP guideline classification for lipid treatment.
  
  
  METHODS
  Multislice computed tomography was performed in 114 consecutive patients (mean age 57+/-14 y; 59% male) without known coronary artery disease. Subjects were classified into 3 categories (low-, intermediate-, and high-risk) according to their Framingham risk scores (FRS).
  
  
  RESULTS
  Traditional cardiac risk factors were common: hypertension 59%, diabetes 13%, and smoking 22%. On the basis of the FRS, 11% (n=12/114) of the patients met high-risk criteria requiring aggressive cholesterol reduction. Of those in the low- and intermediate-risk groups, MSCT found coronary plaque in 76% (n=77/102), with moderate or severe plaque in 38% (n=39/102), thus reclassifying them in the high-risk category. Use of statin drugs increased from 32% at baseline to 53% (p=0.002) based on MSCT results; statin dose was increased in 31% of the patients who were already on a statin. The mean low-density lipoprotein cholesterol (LDL-c) decreased from 114 mg/dL to 91 mg/dL after MSCT (p<0.001).
  
  
  CONCLUSIONS
  Multislice computed tomography reclassifies a high percentage of patients considered to be low- to intermediate-risk into the high-risk category based on their coronary artery lesions. Thus, the rise in MSCT use at present may have a large impact on clinician practice patterns in lipid-lowering therapy.
authors.affiliation: Department of Cardiology, Cleveland Clinic in Florida, Weston, Florida 33331, USA.
authors.forename: Tudor
authors.initials: T
authors.lastname: Scridon
authors.forename: Gian M
authors.initials: GM
authors.lastname: Novaro
authors.forename: Howard S
authors.initials: HS
authors.lastname: Bush
authors.forename: Craig R
authors.initials: CR
authors.lastname: Asher
authors.forename: Eric
authors.initials: E
authors.lastname: Dandes
authors.forename: Deepa
authors.initials: D
authors.lastname: Kabirdas
authors.forename: Cristiana
authors.initials: C
authors.lastname: Scridon
authors.forename: Bruce T
authors.initials: BT
authors.lastname: Kuo
authors.forename: Mitch
authors.initials: M
authors.lastname: Whiteman
authors.forename: Michael Y
authors.initials: MY
authors.lastname: Shen
mesh_terms: D000368:Aged; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000145:classification / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D017410:Practice Guidelines as Topic; D012307:Risk Factors; D014057:Tomography, X-Ray Computed
chemical_list: D000924:Anticholesteremic Agents
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