Neuropathic pain: translational research and impact for patient care.
Neuropathic pain syndromes (ie, pain after a lesion or disease of the peripheral or central nervous system) are clinically characterized by spontaneous pain (ongoing, paroxysms) and evoked types of pain (hyperalgesia, allodynia). Different pathophysiologic mechanisms occur solitarily or combined at peripheral nociceptors, spinal cord, or in the brain, which cause a broad variety of signs and symptoms. Currently, the medical management is still arduous. Therefore, a new concept was proposed in which pain is analyzed on the basis of underlying mechanisms. The increased knowledge of pain-generating mechanisms and their translation into signs and symptoms may allow for a dissection of the individual mechanisms, and it ultimately should be possible to design optimal treatments for each patient.
Maag
Rainer
R
Division of Neurological Pain Research and Therapy, Department of Neurology, Christian-Albrechts-University Kiel, Schittenhelmstr. 10, 24105 Kiel, Germany.
Baron
Ralf
R
D000344:Afferent Pathways / Q000502:physiology; D006801:Humans; D009433:Neural Inhibition / Q000502:physiology; D009437:Neuralgia / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy*; D009619:Nociceptors / Q000502:physiology
Pain. 2001 May;92(1-2):139-45
11323135
Pain. 2005 Feb;113(3):386-394
15661448
Exp Neurol. 1996 Sep;141(1):113-9
8797673
J Neurobiol. 2004 Oct;61(1):55-71
15362153
Nature. 2000 May 11;405(6783):183-7
10821274
Neurobiol Dis. 2001 Feb;8(1):1-10
11162235
J Neurosci. 2001 Mar 15;21(6):1868-75
11245671
Pain. 2005 Aug;116(3):213-219
15964681
J Neurosurg. 1968 Jul;29(1):48-50
5244625
Can J Neurol Sci. 1993 Feb;20(1):69-72
8467433
Pain. 2005 Apr;114(3):397-407
15777865
Neuroreport. 2001 Nov 16;12(16):3475-8
11733694
Brain. 2002 Feb;125(Pt 2):421-35
11844741
Neurosci Lett. 1981 Dec 11;27(2):211-6
7322453
Lancet. 2002 May 11;359(9318):1655-60
12020526
Brain. 1993 Dec;116 ( Pt 6):1477-96
8293282
Acta Neuropathol. 2003 Jun;105(6):593-602
12734666
J Clin Invest. 2005 Sep;115(9):2393-401
16110328
Ann Neurol. 1993 May;33(5):465-72
8388678
Nat Rev Neurosci. 2003 Jul;4(7):529-39
12838328
J Biol Chem. 2005 Jan 7;280(1):618-27
15513920
Pain. 2003 Mar;102(1-2):1-8
12620591
Brain Behav Immun. 2005 Mar;19(2):104-11
15664782
Pain. 2000 Nov;88(2):161-168
11050371
Neurosci Lett. 1987 Nov 10;82(1):35-40
3696482
Neurosci Lett. 1994 Jan 3;165(1-2):97-100
8015746
Pain. 1994 Jun;57(3):375-382
7936715
Neurobiol Dis. 1996;3(3):205-14
8980021
Brain Res Brain Res Rev. 2004 Nov;46(3):295-309
15571771
Neuroscience. 1997 Nov;81(1):255-62
9300418
Brain. 2005 Aug;128(Pt 8):1847-54
15958509
Muscle Nerve. 2004 Mar;29(3):387-92
14981738
Lancet. 2000 Sep 2;356(9232):785-7
11022922
Muscle Nerve. 2006 Jan;33(1):42-8
16228968
Ann Neurol. 1998 Nov;44(5):789-95
9818935
J Neurol. 2005 Jun;252(6):677-86
15778907
Brain. 2003 Mar;126(Pt 3):567-78
12566278
Curr Opin Neurol. 2003 Oct;16(5):623-8
14501847
Neurobiol Dis. 1998 Oct;5(4):209-27
9848092
J Neurol Neurosurg Psychiatry. 1979 May;42(5):422-35
448382
Neurology. 2005 Jul 26;65(2):311-3
16043808
Pain. 1995 Oct;63(1):11-20
8577481
Brain. 2004 May;127(Pt 5):1159-71
14985268
Ann N Y Acad Sci. 2000;909:12-24
10911921
Diabet Med. 2004 Sep;21(9):976-82
15317601
J Neurosci. 2004 May 19;24(20):4832-9
15152043
Science. 2000 Apr 14;288(5464):306-13
10764638
Nat Clin Pract Neurol. 2006 Feb;2(2):95-106
16932531
Eur J Neurosci. 2001 Jun;13(11):2105-14
11422451
Pain. 1992 May;49(2):163-173
1608643
J Neurocytol. 1993 May;22(5):334-41
8315414
Pain. 1988 Jan;32(1):89-94
3340426
Brain. 1994 Feb;117 ( Pt 1):185-97
8149211
Anesthesiology. 2000 Mar;92(3):691-8
10719948
Pain. 1992 Nov;51(2):175-194
1484715
Pain. 2000 Nov;88(2):125-133
11050367
Eur J Pain. 2006 Feb;10(2):127-35
16310716
Pain. 1998 Sep;77(3):227-229
9808347
Pain. 1997 Jan;69(1-2):55-63
9060013