Synthesis of novel cyclopropyl nucleoside analogues as potential antiherpetic agent.
Synthesis of novel cyclopropyl pyrimidine and purine nucleoside derivatives was successfully achieved using one pot reactions including an alkylation, an oxirane-ring opening reaction and a lactonization and a hydroboration-oxidation as the key steps in order to find new antiherpetic agent.
Kang
Jin-Ah
JA
College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan 609-735, Korea.
Park
Ah-Young
AY
Lee
Hyung-Rock
HR
Kim
Won Hee
WH
Chun
Pusoon
P
Jeong
Lak Shin
LS
Moon
Hyung Ryong
HR
D000225:Adenine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry; D006564:Herpesviridae / Q000187:drug effects; D013941:Thymine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
D000998:Antiviral Agents; D000225:Adenine; D013941:Thymine