title: Tumor-infiltrating macrophages can predict favorable prognosis in hepatocellular carcinoma after resection.
abstract: OBJECTIVE
  To evaluate the prognostic value of tumor-associated macrophages (TAM), individually or synergistically with CD45RO + memory T cells (T(M)), in hepatocellular carcinoma (HCC) patients following resection.
  
  
  METHODS
  The infiltration of TAM and T(M) was assessed by immunohistochemistry in tissue microarray containing 302 HCC specimens. Correlations between TAM/T(M) infiltration and clinicopathologic features, disease-free survival (DFS) and overall survival (OS) were statistically analyzed.
  
  
  RESULTS
  High TAM infiltration was associated with both improved DFS (P = 0.0021) and OS (P = 0.0481). Multivariate analysis identified TAM infiltration as independent prognostic factor for DFS (P = 0.004) and OS (P = 0.049). A second analysis clarified the synergistic effect of TAM&T(M) infiltration for DFS (P = 0.004) and OS (P = 0.040).
  
  
  CONCLUSIONS
  Both TAM infiltration alone and concomitant infiltration of TAM&T(M) are associated with improved DFS/OS, suggesting that TAM could protect HCC patients from recurrence/metastasis and prolong survival by distinct mechanisms.
authors.affiliation: Liver Cancer Institute, Zhong Shan Hospital and Institutes of Biomedical Sciences, Shanghai Medical School, Fudan University, 136 Yi Xue Yuan Road, 200032, Shanghai, People's Republic of China.
authors.forename: Yi-Wei
authors.initials: YW
authors.lastname: Li
authors.forename: Shuang-Jian
authors.initials: SJ
authors.lastname: Qiu
authors.forename: Jia
authors.initials: J
authors.lastname: Fan
authors.forename: Qiang
authors.initials: Q
authors.lastname: Gao
authors.forename: Jian
authors.initials: J
authors.lastname: Zhou
authors.forename: Yong-Sheng
authors.initials: YS
authors.lastname: Xiao
authors.forename: Yang
authors.initials: Y
authors.lastname: Xu
authors.forename: Xiao-Ying
authors.initials: XY
authors.lastname: Wang
authors.forename: Jian
authors.initials: J
authors.lastname: Sun
authors.forename: Xiao-Wu
authors.initials: XW
authors.lastname: Huang
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000276:immunology / Q000473:pathology* / Q000601:surgery*; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D006801:Humans; D017493:Leukocyte Common Antigens / Q000276:immunology; D008113:Liver Neoplasms / Q000276:immunology / Q000473:pathology* / Q000601:surgery*; D008264:Macrophages / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D020411:Oligonucleotide Array Sequence Analysis; D011379:Prognosis; D017741:Survivors; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D004273:DNA, Neoplasm; D000509:alpha-Fetoproteins; D017493:Leukocyte Common Antigens
references.citation: Clin Cancer Res. 2007 Oct 1;13(19):5784-9
references.pmid: 17908969
references.citation: Clin Immunol. 2002 Mar;102(3):291-301
references.pmid: 11890716
references.citation: Annu Rev Immunol. 1997;15:323-50
references.pmid: 9143691
references.citation: Eur J Cancer. 2006 Apr;42(6):717-27
references.pmid: 16520032
references.citation: Science. 2006 Sep 29;313(5795):1960-4
references.pmid: 17008531
references.citation: Cancer Immunol Immunother. 1998 Jan;45(5):225-33
references.pmid: 9439645
references.citation: J Exp Clin Cancer Res. 2006 Sep;25(3):365-72
references.pmid: 17167977
references.citation: World J Gastroenterol. 2005 Nov 7;11(41):6521-4
references.pmid: 16425427
references.citation: Med Hypotheses. 2005;64(4):751-4
references.pmid: 15694692
references.citation: Int J Oncol. 2000 Sep;17(3):445-51
references.pmid: 10938382
references.citation: Clin Exp Metastasis. 2002;19(3):247-58
references.pmid: 12067205
references.citation: J Clin Oncol. 2007 Jun 20;25(18):2586-93
references.pmid: 17577038
references.citation: Oncol Rep. 2005 Aug;14(2):425-31
references.pmid: 16012726
references.citation: Clin Cancer Res. 2007 Mar 1;13(5):1472-9
references.pmid: 17332291
references.citation: Immunol Rev. 2004 Dec;202:96-105
references.pmid: 15546388
references.citation: Nature. 1992 Nov 19;360(6401):264-5
references.pmid: 1436108
references.citation: J Clin Invest. 2004 Sep;114(5):623-33
references.pmid: 15343380
references.citation: J Clin Oncol. 2007 Jun 20;25(18):2506-8
references.pmid: 17577026
references.citation: Immunity. 2004 Aug;21(2):137-48
references.pmid: 15308095
references.citation: FEBS Lett. 2006 May 29;580(13):3042-50
references.pmid: 16678166
references.citation: Cancer Res. 2006 Jan 15;66(2):605-12
references.pmid: 16423985
references.citation: Dig Liver Dis. 2002 Nov;34(11):794-801
references.pmid: 12546515
references.citation: Nature. 2001 Mar 1;410(6824):24-5
references.pmid: 11242022
references.citation: J Leukoc Biol. 1993 Dec;54(6):613-26
references.pmid: 8245715
references.citation: N Engl J Med. 2005 Dec 22;353(25):2654-66
references.pmid: 16371631
references.citation: CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108
references.pmid: 15761078
references.citation: Anticancer Res. 2003 Nov-Dec;23(6D):5015-22
references.pmid: 14981961
references.citation: Nat Rev Cancer. 2006 Jan;6(1):24-37
references.pmid: 16397525
references.citation: Eur J Surg Oncol. 2005 Sep;31(7):760-7
references.pmid: 15975760
references.citation: Hepatology. 2006 Feb;43(2 Suppl 1):S54-62
references.pmid: 16447271
references.citation: J Exp Med. 1991 May 1;173(5):1047-52
references.pmid: 2022919
references.citation: Cancer Cell. 2006 Aug;10(2):99-111
references.pmid: 16904609
references.citation: J Cancer Res Clin Oncol. 2006 May;132(5):293-301
references.pmid: 16421755
references.citation: Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2774-8
references.pmid: 8464888
references.citation: Blood. 2004 Oct 15;104(8):2224-34
references.pmid: 15231578
references.citation: Anticancer Res. 2004 Sep-Oct;24(5C):3335-42
references.pmid: 15515429
references.citation: Nat Rev Cancer. 2004 Jan;4(1):71-8
references.pmid: 14708027
references.citation: J Hepatol. 2006 Aug;45(2):246-53
references.pmid: 16580084
references.citation: Anticancer Res. 2002 Nov-Dec;22(6C):4269-75
references.pmid: 12553068
references.citation: Cancer Res. 2007 Sep 15;67(18):8874-81
references.pmid: 17875729
references.citation: Cancer Res. 2007 Apr 15;67(8):3500-4
references.pmid: 17413003