Dopaminergic modulation of semantic priming in Parkinson disease.
OBJECTIVE
Our purpose is to examine the effect of D2/D3 agonists on semantic priming.


BACKGROUND
Dopamine seems to restrict the semantic network in semantic priming. However, which dopamine receptor mediates this effect is unknown.


METHODS
To better understand the receptors involved, 15 nondemented Parkinson disease patients performed a lexical decision task before and 1 hour after they received their first morning medication dose, 8 after D2 and D3 agonists pramipexole or ropinirole, and 7 after L-dopa. Semantic priming was measured for closely, distantly, and unrelated word pairs across a stimulus onset asynchrony of 700 ms.


RESULTS
Closely related pairs were recognized significantly faster than unrelated and distantly related pairs before the drugs, as well as after D2/D3 agents. After L-dopa, closely related pairs remained faster than unrelated, but not faster than distantly related pairs.


CONCLUSIONS
This suggests that D1 receptors may mediate the dopaminergic modulation of semantic priming.
Pederzolli
Andrew S
AS
The Ohio State University College of Medicine and Public Health, Columbus, OH, USA.
Tivarus
Madalina E
ME
Agrawal
Punit
P
Kostyk
Sandra K
SK
Thomas
Karen M
KM
Beversdorf
David Q
DQ
D000978:Antiparkinson Agents / Q000627:therapeutic use; D052160:Benzothiazoles / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy / Q000235:genetics*; D000077487:Pramipexole; D017447:Receptors, Dopamine D1 / Q000235:genetics*; D017448:Receptors, Dopamine D2 / Q000235:genetics*
D000978:Antiparkinson Agents; D052160:Benzothiazoles; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D000077487:Pramipexole
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