Systems pathology--or how to solve the complex problem of predictive pathology.
To understand the extreme complexity of biological events requires a systemic approach. This holds particularly for the disordered biological interactions that are characteristic of disease, the subject of pathology. Which options are available to untie the Gordian knot? In this contribution, the potential role of systems biology and, as a further development, systems pathology will be discussed.
Dietel
Manfred
M
Department of Pathology, Charité-University Medicine Berlin, Charitéplatz 1, 10117, Berlin, Germany. manfred.dietel@charite.de
Schäfer
Reinhold
R
D003933:Diagnosis; D005544:Forecasting; D017143:Fuzzy Logic; D006801:Humans; D007256:Information Systems; D008954:Models, Biological; D010338:Pathology, Clinical; D049490:Systems Biology; D014584:User-Computer Interface
Brain Nerve. 2011 Jan;63(1):88-9
21516882
Nat Rev Drug Discov. 2005 Dec;4(12):961-7
16341061
J Pathol. 2007 Aug;212(4):353-5
17573671
Nat Clin Pract Urol. 2007 Jan;4(1):39-45
17211424
Curr Opin Biotechnol. 2008 Aug;19(4):381-8
18634875
Mol Syst Biol. 2005;1:2005.0010
16729045
Brain Nerve. 2010 Dec;62(12):1358-9
21305806
Science. 1993 Dec 24;262(5142):1953
8266084