Albumin competitively inhibits glycation of less abundant proteins.
Glycation, a non-enzymatic reaction between glucose and protein is the primary cause of diabetic complications. Albumin, the most abundant plasma protein undergoes glycation both in vivo and in vitro. The influence of albumin on glycation of less abundant proteins has not been addressed. For the first time, we show that albumin competitively inhibits the glycation of less abundant proteins. This study suggests that at least in the initial stages of diabetes, albumin may protect other proteins from glycation.
Bhonsle
Hemangi S
HS
Division of Organic Chemistry, National Chemical Laboratory, Pune, India.
Singh
Sameer Kumar
SK
Srivastava
Ghanshyam
G
Boppana
Ramanamurthy
R
Kulkarni
Mahesh J
MJ
D001059:Apoproteins / Q000737:chemistry / Q000378:metabolism; D001667:Binding, Competitive; D002256:Carbonic Anhydrases / Q000378:metabolism; D048909:Diabetes Complications / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000737:chemistry / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D066298:In Vitro Techniques; D007328:Insulin / Q000737:chemistry / Q000378:metabolism; D007700:Kinetics; D009211:Myoglobin / Q000737:chemistry / Q000378:metabolism; D010206:Papain / Q000378:metabolism; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D012709:Serum Albumin / Q000737:chemistry* / Q000378:metabolism*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D001059:Apoproteins; D017127:Glycation End Products, Advanced; D007328:Insulin; D009211:Myoglobin; D011506:Proteins; D012709:Serum Albumin; C010857:apomyoglobin; D010206:Papain; D002256:Carbonic Anhydrases