Novelty-induced locomotion is positively associated with cocaine ingestion in adolescent rats; anxiety is correlated in adults.
The present studies assessed the roles of sex, age, novelty-seeking and plus-maze behavior on cocaine drinking in rats. Cocaine/saccharin solution was available in three daily, 5-hour sessions then a saccharin-only solution was also available in following sessions. In the one-bottle drinking phase, early and late adolescent males, post-natal day 28 (PN28) and PN42, consumed more cocaine/saccharin solution than young adults (PN65), but females did not exhibit significant age differences. Adolescents of both sexes consumed more cocaine/saccharin than adults during choice drinking. Saccharin availability in the two-bottle trials decreased cocaine/saccharin consumption in PN28 and PN65 rats. After a drug-free period, cocaine-stimulated locomotion was lower in cocaine/saccharin drinking than saccharin-only males, indicating tolerance. We tested the hypothesis that individual differences in pre-screened behavioral traits would correlate with cocaine/saccharin consumption in PN28 and PN65 male rats. High locomotor responses to novelty were associated with greater cocaine/saccharin drinking in adults in one-bottle sessions. In the subsequent choice drinking phase, correlations were age-specific. Adolescents with high novelty-induced locomotion and adults that spent less time on open arms of the elevated plus-maze drank more cocaine/saccharin. Thus, behavioral phenotypes correlated with individual differences in cocaine/saccharin consumption in an age-related manner.
Walker
Q David
QD
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, United States.
Schramm-Sapyta
Nicole L
NL
Caster
Joseph M
JM
Waller
Samuel T
ST
Brooks
Matthew P
MP
Kuhn
Cynthia M
CM
D000375:Aging / Q000523:psychology*; D000818:Animals; D001007:Anxiety / Q000523:psychology*; D003042:Cocaine / Q000737:chemistry / Q000494:pharmacology; D019970:Cocaine-Related Disorders / Q000523:psychology*; D003627:Data Interpretation, Statistical; D004777:Environment; D005260:Female; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D019999:Pharmaceutical Solutions; D051381:Rats; D012201:Reward; D012727:Sex Characteristics
D019999:Pharmaceutical Solutions; D003042:Cocaine
NIDA Res Monogr. 1986;74:59-70
3122054
Dev Psychobiol. 1999 Sep;35(2):136-45
10461127
Psychopharmacology (Berl). 2007 Oct;194(3):403-11
17609932
Nat Neurosci. 2005 Nov;8(11):1450-7
16251987
Psychopharmacology (Berl). 2004 Jan;171(3):277-85
12961061
Psychopharmacology (Berl). 2001 Aug;156(4):435-44
11498721
Neurosci Biobehav Rev. 2000 Jun;24(4):417-63
10817843
Neuropsychopharmacology. 2004 May;29(5):869-78
14666123
Clin Pediatr (Phila). 1989 Dec;28(12):550-5
2582695
Psychopharmacology (Berl). 2001 Mar 1;154(2):143-52
11314676
Ann N Y Acad Sci. 2004 Jun;1021:167-74
15251887
Psychopharmacology (Berl). 2003 Apr;167(1):1-8
12607073
Drug Alcohol Depend. 1998 Jan 1;49(2):115-21
9543648
Pharmacol Biochem Behav. 2002 Nov;73(4):743-52
12213518
Endocrinology. 2005 Jan;146(1):137-46
15375029
Arch Gen Psychiatry. 1997 Jan;54(1):62-8
9006402
J Chromatogr B Biomed Sci Appl. 2000 Aug 18;745(2):315-23
11043750
Am J Drug Alcohol Abuse. 2004 Nov;30(4):749-64
15624547
Pharmacol Biochem Behav. 1992 Sep;43(1):243-8
1409810
Drug Alcohol Depend. 1997 Jun 6;46(1-2):53-67
9246553
Annu Rev Neurosci. 2006;29:565-98
16776597
J Pers Soc Psychol. 1998 Feb;74(2):387-406
9491584
Science. 1978 Apr 14;200(4338):211-3
24895
Proc Natl Acad Sci U S A. 1988 Jul;85(14):5274-8
2899326
J Neurosci. 2005 Jan 5;25(1):149-56
15634776
Horm Behav. 2006 Sep;50(3):463-8
16836997
J Neurosci. 2000 Jun 1;20(11):4226-32
10818158
J Neurosci Methods. 1985 Aug;14(3):149-67
2864480
Drug Alcohol Depend. 1995 Nov;40(1):1-7
8746918
J Anxiety Disord. 2005;19(3):275-94
15686857
Trends Pharmacol Sci. 2004 May;25(5):273-9
15120494
Exp Clin Psychopharmacol. 2005 Nov;13(4):367-75
16366767
Pharmacol Biochem Behav. 1992 Sep;43(1):45-51
1409818
Drug Alcohol Depend. 1996 Sep;42(1):27-37
8889401
J Addict Dis. 2004;23(1):93-109
15077843
Science. 1989 Sep 29;245(4925):1511-3
2781295
Pharmacol Biochem Behav. 2001 Feb;68(2):291-9
11267634
Neuropsychopharmacology. 2002 Aug;27(2):212-24
12093595
Neuroscience. 2000;95(4):1061-70
10682713
Psychopharmacology (Berl). 2002 Nov;164(2):121-37
12404074
J Subst Abuse. 1994;6(1):1-20
8081104
Neuropsychopharmacology. 2007 Mar;32(3):625-37
16794567
PLoS One. 2007 Aug 01;2(8):e698
17668074
Psychopharmacology (Berl). 2005 Dec;183(2):218-25
16175404
Neuropharmacology. 1978 Dec;17(12):1081-4
570650
Neuropsychopharmacology. 2004 May;29(5):929-42
14735136
Brain Res. 1995 Nov 6;698(1-2):46-52
8581502
Neuropsychopharmacology. 2005 Apr;30(4):705-12
15496937
Psychopharmacology (Berl). 2003 Sep;169(2):141-9
12764575
Science. 2004 Aug 13;305(5686):1017-9
15310907
Behav Brain Res. 1996 May;77(1-2):23-43
8762157
Neuroscience. 1998 Apr;83(3):681-9
9483552
Psychopharmacology (Berl). 2003 Oct;170(1):9-16
12838382
Psychol Med. 2006 Mar;36(3):299-312
16472412
Pharmacol Biochem Behav. 2006 Jun;84(2):344-52
16815539
Prog Neuropsychopharmacol Biol Psychiatry. 1998 Jan;22(1):229-39
9533178
Am J Psychiatry. 2003 Jun;160(6):1041-52
12777258
Neuropsychopharmacology. 2006 Jun;31(6):1193-202
16237396
Neurotoxicol Teratol. 2008 Sep-Oct;30(5):412-8
18508233
Behav Pharmacol. 2001 Jul;12(4):267-75
11548112
Ann N Y Acad Sci. 2004 Jun;1021:148-59
15251884
J Pharmacol Exp Ther. 1991 Apr;257(1):444-56
2020002
Psychopharmacology (Berl). 1989;98(3):408-11
2501818
Eur J Neurosci. 2002 May;15(9):1542-50
12028365
Psychoneuroendocrinology. 2005 Oct;30(9):880-91
15975729
NIDA Res Monogr. 1985;56:178-92
3929100
Drug Alcohol Depend. 1998 Jun-Jul;51(1-2):13-22
9716927
Life Sci. 1980 Apr 21;26(16):1275-82
6991841
Brain Res. 2005 Jul 5;1049(1):128-31
15935999
Exp Clin Psychopharmacol. 2007 Feb;15(1):37-47
17295583
J Exp Anal Behav. 1998 Sep;70(2):185-201
9768506
Psychopharmacology (Berl). 1997 Feb;129(3):277-84
9084067
Science. 2004 Aug 13;305(5686):1014-7
15310906
Pharmacol Biochem Behav. 2003 May;75(2):411-8
12873633
Arch Gen Psychiatry. 2003 Aug;60(8):837-44
12912767
J Neurosci. 2000 Dec 1;20(23):8876-85
11102497
Pharmacol Biochem Behav. 2008 May;89(3):314-23
18275993
J Pharmacol Exp Ther. 1991 Apr;257(1):457-65
2020003
Pharmacol Biochem Behav. 1995 Aug;51(4):725-9
7675851
Pharmacol Biochem Behav. 2002 Oct;73(3):663-71
12151042
Physiol Rev. 1991 Jan;71(1):155-234
1986388
Psychopharmacology (Berl). 2007 Aug;193(2):247-60
17426961
Am J Drug Alcohol Abuse. 2003 Aug;29(3):539-51
14510039
Trends Pharmacol Sci. 1992 May;13(5):177-84
1604710
Nebr Symp Motiv. 2004;50:127-58
15160640
Behav Neurosci. 2003 Oct;117(5):927-38
14570543
Psychopharmacology (Berl). 1991;103(4):455-61
2062985
Neurosci Biobehav Rev. 1996;20(1):1-25
8622814
Pharmacol Biochem Behav. 1992 Sep;43(1):235-41
1409809
Behav Neurosci. 2001 Jun;115(3):683-94
11439457
Neurochem Int. 2005 Feb;46(3):189-203
15670635
Drug Alcohol Depend. 2004 Dec 7;76 Suppl:S45-52
15555816
Biol Psychiatry. 2003 Dec 15;54(12):1330-7
14675796
Neurosci Biobehav Rev. 2004 Oct;28(6):533-46
15527861
Trends Neurosci. 1999 Nov;22(11):521-7
10529820
Ann N Y Acad Sci. 2004 Jun;1021:27-32
15251871
J Exp Anal Behav. 1993 Jul;60(1):219-38
8354968