title: Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13.
abstract: The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.
authors.affiliation: Arthritis Research Campaign, Epidemiology Unit, The University of Manchester, Manchester, UK. anne.barton@manchester.ac.uk
authors.forename: Anne
authors.initials: A
authors.lastname: Barton
authors.forename: Wendy
authors.initials: W
authors.lastname: Thomson
authors.forename: Xiayi
authors.initials: X
authors.lastname: Ke
authors.forename: Steve
authors.initials: S
authors.lastname: Eyre
authors.forename: Anne
authors.initials: A
authors.lastname: Hinks
authors.forename: John
authors.initials: J
authors.lastname: Bowes
authors.forename: Darren
authors.initials: D
authors.lastname: Plant
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Gibbons
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Wilson
authors.forename: Deborah E
authors.initials: DE
authors.lastname: Bax
authors.forename: Ann W
authors.initials: AW
authors.lastname: Morgan
authors.forename: Paul
authors.initials: P
authors.lastname: Emery
authors.forename: Sophia
authors.initials: S
authors.lastname: Steer
authors.forename: Lynne
authors.initials: L
authors.lastname: Hocking
authors.forename: David M
authors.initials: DM
authors.lastname: Reid
authors.forename: Paul
authors.initials: P
authors.lastname: Wordsworth
authors.forename: Pille
authors.initials: P
authors.lastname: Harrison
authors.forename: Jane
authors.initials: J
authors.lastname: Worthington
mesh_terms: D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics*; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics*; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
references.citation: Cytokine Growth Factor Rev. 2006 Oct;17(5):349-66
references.pmid: 16911870
references.citation: J Biol Chem. 2005 Mar 25;280(12):10955-63
references.pmid: 15677453
references.citation: Neurology. 2004 Sep 28;63(6):1108-10
references.pmid: 15452312
references.citation: Nat Genet. 2007 Dec;39(12):1431-3
references.pmid: 17982455
references.citation: Arthritis Rheum. 2005 Nov;52(11):3433-8
references.pmid: 16255021
references.citation: Immunity. 2003 Nov;19(5):637-40
references.pmid: 14614850
references.citation: Hum Mol Genet. 2008 Aug 1;17(15):2274-9
references.pmid: 18434327
references.citation: Nature. 2007 Jun 7;447(7145):661-78
references.pmid: 17554300
references.citation: Nat Genet. 2007 Dec;39(12):1477-82
references.pmid: 17982456
references.citation: Nat Genet. 2008 Oct;40(10):1216-23
references.pmid: 18794853
references.citation: Pharmacol Res. 2007 Jun;55(6):537-44
references.pmid: 17544292
references.citation: Nature. 2007 Jul 26;448(7152):470-3
references.pmid: 17611496