Oxidants and the pathogenesis of lung diseases.
The increasing number of population-based and epidemiologic associations between oxidant pollutant exposures and cardiopulmonary disease exacerbation, decrements in pulmonary function, and mortality underscores the important detrimental effects of oxidants on public health. Because inhaled oxidants initiate a number of pathologic processes, including inflammation of the airways, which may contribute to the pathogenesis and/or exacerbation of airways disease, it is critical to understand the mechanisms through which exogenous and endogenous oxidants interact with molecules in the cells, tissues, and epithelial lining fluid of the lung. Furthermore, it is clear that interindividual variation in response to a given exposure also exists across an individual lifetime. Because of the potential impact that oxidant exposures may have on reproductive outcomes and infant, child, and adult health, identification of the intrinsic and extrinsic factors that may influence susceptibility to oxidants remains an important issue. In this review, we discuss mechanisms of oxidant stress in the lung, the role of oxidants in lung disease pathogenesis and exacerbation (eg, asthma, chronic obstructive pulmonary disease, and acute respiratory distress syndrome), and the potential risk factors (eg, age, genetics) for enhanced susceptibility to oxidant-induced disease.
Ciencewicki
Jonathan
J
Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Trivedi
Shweta
S
Kleeberger
Steven R
SR
D000367:Age Factors; D000393:Air Pollutants / Q000633:toxicity*; D000485:Allergens; D000818:Animals; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008171:Lung Diseases / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D016877:Oxidants / Q000378:metabolism / Q000633:toxicity*; D018384:Oxidative Stress; D010126:Ozone / Q000378:metabolism / Q000633:toxicity*; D011494:Protein Kinases / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism / Q000633:toxicity*; D012307:Risk Factors; D014157:Transcription Factors / Q000378:metabolism
D000393:Air Pollutants; D000485:Allergens; D016877:Oxidants; D017382:Reactive Oxygen Species; D014157:Transcription Factors; D010126:Ozone; D011494:Protein Kinases
Pharmacogenetics. 1991 Nov;1(2):110-3
1844868
N Engl J Med. 2000 Dec 14;343(24):1742-9
11114312
Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8945-50
15184672
J Appl Toxicol. 2007 May-Jun;27(3):284-90
17265450
Am J Respir Crit Care Med. 2003 Feb 1;167(3):395-9
12411284
Environ Health Perspect. 2004 Oct;112(14):1365-71
15471726
Chem Res Toxicol. 2002 Jul;15(7):896-906
12118999
Environ Health Perspect. 1998 Jun;106(6):325-9
9618348
Environ Res. 2003 Nov;93(3):279-84
14615238
Annu Rev Pharmacol Toxicol. 2007;47:89-116
16968214
Epidemiology. 2001 Mar;12(2):200-8
11246581
Inhal Toxicol. 2007 Feb;19(2):161-8
17169863
J Exp Med. 2005 Jul 4;202(1):47-59
15998787
JAMA. 2006 Mar 8;295(10):1127-34
16522832
Environ Health Perspect. 2000 Feb;108(2):173-6
10656859
N Engl J Med. 2008 Apr 17;358(16):1700-11
18420502
Am J Respir Crit Care Med. 1995 Jan;151(1):33-40
7812569
Thorax. 2007 Mar;62(3):231-6
17040936
Pediatr Pulmonol. 2000 Aug;30(2):79-85
10922128
Am J Respir Crit Care Med. 1999 Dec;160(6):1934-42
10588609
Free Radic Res. 2006 Sep;40(9):901-9
17015269
J Pharmacol Exp Ther. 2007 Jul;322(1):351-9
17460151
Epidemiology. 2004 Mar;15(2):143-9
15127905
Mutat Res. 2005 Aug 1;585(1-2):60-70
15923135
J Biol Chem. 1999 Jan 22;274(4):2234-42
9890986
Am J Respir Crit Care Med. 1996 Aug;154(2 Pt 1):300-7
8756798
Am J Physiol Lung Cell Mol Physiol. 2004 Oct;287(4):L685-703
15355860
Am J Respir Crit Care Med. 2008 Jun 15;177(12):1331-7
18337595
Epidemiology. 1997 May;8(3):298-303
9115026
Pharmacol Ther. 2006 Aug;111(2):476-94
16458359
Neuroscience. 1997 Oct;80(3):685-96
9276486
FASEB J. 2007 Jul;21(9):2237-46
17384144
Inhal Toxicol. 2005 Aug;17(9):467-73
16020041
Am J Respir Crit Care Med. 2000 Oct;162(4 Pt 1):1273-6
11029330
Nat Genet. 1997 Dec;17(4):475-8
9398854
J Allergy Clin Immunol. 2006 Oct;118(4):823-30
17030233
Environ Health Perspect. 2008 May;116(5):680-6
18470315
Environ Health Perspect. 2008 Jan;116(1):110-5
18197308
Pediatrics. 2003 Jul;112(1 Pt 2):233-9
12837915
J Immunol. 2001 May 1;166(9):5763-72
11313420
Am J Respir Crit Care Med. 2007 Oct 15;176(8):742-7
17673694
Environ Health Perspect. 2007 Sep;115(9):1283-92
17805417
Eur Respir J. 2007 Oct;30(4):616-22
17906084
Proc Nutr Soc. 2005 Nov;64(4):510-26
16313695
Am J Respir Crit Care Med. 2002 Aug 15;166(4):490-5
12186826
Environ Health Perspect. 2001 Jun;109 Suppl 3:351-6
11427384
Chem Res Toxicol. 2001 Oct;14(10):1371-7
11599928
J Allergy Clin Immunol. 2004 Aug;114(2):260-4
15316500
Am J Respir Cell Mol Biol. 2000 May;22(5):620-7
10783135
Respir Med. 1999 Jun;93(6):389-96
10464820
Environ Health Perspect. 2003 Nov;111(14):1773-8
14594630
Free Radic Biol Med. 1999 Dec;27(11-12):1251-8
10641718
Am J Epidemiol. 2000 Mar 15;151(6):602-13
10733042
Free Radic Biol Med. 1995 Dec;19(6):935-41
8582671
Eur Respir J Suppl. 2003 May;40:39s-46s
12762573
Toxicol Appl Pharmacol. 1996 Dec;141(2):416-24
8975766
Thorax. 2001 Jan;56(1):13-8
11120898
Toxicol Appl Pharmacol. 1996 Jul;139(1):135-43
8685896
Semin Respir Crit Care Med. 2006 Aug;27(4):337-49
16909368
Chem Res Toxicol. 2001 Jul;14(7):879-87
11453735
Prog Lipid Res. 1997 Mar;36(1):1-21
9373618
Paediatr Perinat Epidemiol. 2004 Sep;18(5):327-35
15367319
Toxicol Appl Pharmacol. 2005 Oct 1;208(1):37-45
16164960
J Appl Physiol (1985). 1996 May;80(5):1560-7
8727540
Biochemistry. 2007 May 8;46(18):5604-15
17425286
Am J Respir Crit Care Med. 2003 Nov 15;168(10):1199-204
12969868
Environ Health Perspect. 2007 Dec;115(12):1732-7
18087591
Thorax. 2004 Jan;59(1):8-10
14694237
Amino Acids. 2003 Dec;25(3-4):375-96
14661098
Free Radic Biol Med. 1997;22(7):1301-7
9098106
Clin Exp Allergy. 2007 Sep;37(9):1312-9
17845411
Toxicol Appl Pharmacol. 1998 Jun;150(2):338-49
9653065
Lancet. 2002 Feb 2;359(9304):386-91
11844508
Am J Respir Cell Mol Biol. 2002 Feb;26(2):175-82
11804867
J Toxicol Environ Health A. 2007 Feb 1;70(3-4):284-94
17365591
Occup Environ Med. 2008 Nov;65(11):736-42
18524839
Toxicol Sci. 2004 Feb;77(2):263-71
14657513
Pediatrics. 2004 Jun;113(6):e628-31
15173546
Pulm Pharmacol Ther. 2007;20(5):596-605
16919984
Methods Enzymol. 1994;233:229-40
8015460
Am J Physiol Cell Physiol. 2006 Jan;290(1):C262-70
16162662
Am J Respir Crit Care Med. 2005 Apr 15;171(8):804-5
15817805
Chest. 2001 Oct;120(4):1136-9
11591550
Free Radic Biol Med. 1996;21(5):669-81
8891669
Am J Physiol Lung Cell Mol Physiol. 2000 Dec;279(6):L1137-45
11076804
Toxicol Appl Pharmacol. 2002 Oct 1;184(1):1-10
12392963
Am J Physiol. 1997 Dec;273(6):L1265-75
9435583
Environ Health Perspect. 2002 Aug;110 Suppl 4:565-8
12194888
Free Radic Biol Med. 2002 Sep 15;33(6):847-56
12208372
J Clin Invest. 2000 May;105(10):1455-63
10811853
Am J Respir Crit Care Med. 2003 May 15;167(10):1380-6
12522029
Mediators Inflamm. 2006;2006(2):36735
16883063
Epidemiology. 2000 Sep;11(5):502-11
10955401
Thorax. 2008 Jun;63(6):555-63
18511640
Am J Respir Cell Mol Biol. 2008 Dec;39(6):673-82
18566336
Am J Respir Crit Care Med. 1999 Feb;159(2):473-9
9927360
Lancet. 2007 Feb 17;369(9561):571-7
17307103
J Allergy Clin Immunol. 2003 Jan;111(1):72-8
12532099
J Allergy Clin Immunol. 2004 Nov;114(5):1116-23
15536419
Free Radic Biol Med. 2002 Mar 15;32(6):492-502
11958950
Am J Physiol Lung Cell Mol Physiol. 2008 Jan;294(1):L121-30
17981957
Am J Respir Crit Care Med. 1996 Oct;154(4 Pt 1):1055-60
8887607
Pediatrics. 2003 Feb;111(2):284-90
12563052
Am J Respir Crit Care Med. 1999 Jul;160(1):216-20
10390403
Am J Respir Crit Care Med. 1996 Mar;153(3):904-9
8630571
Am Rev Respir Dis. 1985 Jan;131(1):36-40
3966712
J Pathol. 2004 Feb;202(2):145-56
14743496
Br J Nutr. 2009 Jan;101(1):86-92
18507882
Am J Respir Cell Mol Biol. 2006 Feb;34(2):174-81
16195535
Free Radic Biol Med. 2005 Feb 15;38(4):515-26
15649654
Thorax. 1997 Dec;52 Suppl 5:S1-28
9474238
Arch Biochem Biophys. 1999 Aug 15;368(2):303-18
10441382
Antioxid Redox Signal. 2006 Jan-Feb;8(1-2):88-98
16487041
Am J Respir Crit Care Med. 1994 Mar;149(3 Pt 1):818-24
7509706
Toxicol Appl Pharmacol. 2002 Nov 1;184(3):127-35
12460740
Environ Health Perspect. 2008 Apr;116(4):550-8
18414642
Am J Epidemiol. 2000 Jan 1;151(1):50-6
10625173
Shock. 1998 May;9(5):336-40
9617882
Am J Respir Crit Care Med. 2006 May 1;173(9):970-6
16456144
J Biol Chem. 2000 Jun 2;275(22):16702-8
10748119
Am J Respir Crit Care Med. 2001 May;163(6):1426-31
11371413
J Biol Chem. 2000 Sep 1;275(35):27258-65
10867014
Annu Rev Public Health. 2005;26:89-113
15760282
Am J Respir Crit Care Med. 1995 Nov;152(5 Pt 2):S77-121
7582322
Lung. 2006 Mar-Apr;184(2):51-5
16622773
Pflugers Arch. 2008 Sep;456(6):1085-95
18369661
Respir Res. 2006 Jun 01;7:85
16740162
Free Radic Biol Med. 2004 Mar 1;36(5):673-81
14980710
Exp Lung Res. 1989 Dec;15(6):881-94
2612445
Curr Opin Allergy Clin Immunol. 2008 Feb;8(1):49-56
18188018
FASEB J. 1998 Jun;12(9):665-71
9619445
Am J Physiol Lung Cell Mol Physiol. 2004 Jun;286(6):L1169-78
14729514
Immunopharmacol Immunotoxicol. 2007;29(3-4):403-12
18075853
Ann Allergy Asthma Immunol. 2001 Feb;86(2):232-8
11258696
Am J Respir Cell Mol Biol. 1993 Dec;9(6):594-602
8257591
Pediatrics. 2006 Jul;118(1):156-64
16818561
Environ Health Perspect. 2005 Apr;113(4):375-82
15811825
J Toxicol Environ Health A. 2008;71(3):149-65
18097943
J Immunol. 2007 Oct 1;179(7):4367-75
17878331
Inhal Toxicol. 2007 Jul;19(9):759-65
17613084
Chem Res Toxicol. 2000 Oct;13(10):1011-9
11080050
Neurotoxicol Teratol. 2007 Mar-Apr;29(2):211-8
17197156
Circulation. 2004 Jun 1;109(21):2655-71
15173049
Intensive Care Med. 1993;19(2):78-81
8486874
Eur Respir J. 2007 Oct;30(4):677-83
17652311
Inhal Toxicol. 2007 Nov;19(14):1121-33
17987464
Birth Defects Res C Embryo Today. 2007 Sep;81(3):144-54
17963272
Clin Exp Pharmacol Physiol. 2006 Mar;33(3):269-72
16487273
Inhal Toxicol. 2003 Jan;15(1):39-52
12476359
Am J Respir Crit Care Med. 2005 Jan 15;171(2):171-6
15486341
J Biol Chem. 1991 Mar 5;266(7):4244-50
1847917
Br J Surg. 1994 Sep;81(9):1300-5
7953392
J Allergy Clin Immunol. 2001 Apr;107(4):623-6
11295649
J Biol Chem. 2000 Dec 8;275(49):38848-55
10969075
Free Radic Res. 1994 Aug;21(2):95-106
7921168
Environ Health Perspect. 2007 Jul;115(7):1118-24
17637932
Am J Epidemiol. 2002 Jan 1;155(1):17-25
11772780
Am J Respir Cell Mol Biol. 1996 Aug;15(2):275-82
8703485
Annu Rev Med. 2005;56:383-400
15660518
J Allergy Clin Immunol. 1998 Oct;102(4 Pt 1):539-54
9802360
Toxicol Appl Pharmacol. 2007 Apr 1;220(1):72-82
17307210
Eur Respir J. 2003 Aug;22(2):335-41
12952270
Am Rev Respir Dis. 1993 Nov;148(5):1363-72
8239177
N Engl J Med. 2007 Dec 6;357(23):2338-47
18057336
Am J Respir Cell Mol Biol. 2006 Nov;35(5):579-86
16763223
Allergy. 2008 Apr;63(4):438-46
18315731
Adv Exp Med Biol. 1999;463:123-31
10352677
Environ Res. 2007 Jun;104(2):250-7
17303107
Am J Respir Crit Care Med. 2000 Oct;162(4 Pt 1):1450-4
11029360
Am J Physiol. 1990 Jun;258(6 Pt 1):L313-20
2360644
J Toxicol Environ Health A. 2008;71(3):238-43
18097949
Arch Environ Health. 1994 Jul-Aug;49(4):246-50
8031179
Respir Med. 2005 Jan;99(1):84-90
15672854
J Physiol. 2002 Aug 15;543(Pt 1):201-9
12181292
Am J Respir Crit Care Med. 2004 Dec 15;170(12):1317-23
15466253
N Engl J Med. 2007 Nov 8;357(19):1946-55
17989387
Inhal Toxicol. 2007;19 Suppl 1:177-82
17886065
Am J Respir Cell Mol Biol. 2002 Jan;26(1):42-51
11751202
Clin Exp Allergy. 2001 Mar;31(3):387-90
11260149
N Engl J Med. 2004 Sep 9;351(11):1057-67
15356303
COPD. 2004 Apr;1(1):59-70
16997739
Arch Biochem Biophys. 1991 Aug 1;288(2):481-7
1654835
J Basic Clin Physiol Pharmacol. 2001;12(1):59-68
11414508
Am J Respir Crit Care Med. 2001 May;163(6):1304-9
11371392
J Allergy Clin Immunol. 2006 Aug;118(2):455-65
16890772
Am J Epidemiol. 2005 Aug 1;162(3):238-52
15987727
J Korean Med Sci. 2005 Oct;20(5):759-63
16224148