N-Methyl scanning mutagenesis generates protease-resistant G protein ligands with improved affinity and selectivity.
Fiacco
Stephen V
SV
Chemistry Department, University of Southern California, 3710 McClintock Avenue, Los Angeles, USA.
Roberts
Richard W
RW
D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D019204:GTP-Binding Proteins / Q000378:metabolism*; D008024:Ligands; D008969:Molecular Sequence Data; D016296:Mutagenesis; D009842:Oligopeptides / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000378:metabolism*; D011485:Protein Binding; D015202:Protein Engineering / Q000379:methods*; D013379:Substrate Specificity
D008024:Ligands; D009842:Oligopeptides; D010447:Peptide Hydrolases; D019204:GTP-Binding Proteins
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