[Determination of ADAMTS13 antigen and activity levels in patients with acute myocardial infarction and acute ischemic stroke].
OBJECTIVE
To investigate the ADAMTS13 antigen levels and activity in patients with acute myocardial infarction (AMI) and acute ischemic stroke (AIS), and explore its significance in these diseases.


METHODS
ADAMTS13 activity levels were detected by a new developed Frests-vWF73 kit, ADAMTS13 antigen levels by ELISA kit, and vWF multimers by electrophoresis.


RESULTS
ADAMTS13 antigen in normal control, AMI and AIS was (878 +/- 198), (618 +/- 188) and (702 +/- 155) U/L, and ADAMTS13 activity was (81.7 +/- 13.9)%, (59.2 +/- 22.1 )% and (65.4 +/- 15.8)%, respectively, being significantly decreased in AMI and AIS patients.


CONCLUSIONS
ADMATS13 might involve in arterial infarction diseases.
Dong
Ning-Zheng
NZ
iangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Liu
Fang
F
Ji
Shun-Dong
SD
Ruan
Chang-Geng
CG
D051722:ADAM Proteins / Q000097:blood*; D000071120:ADAMTS13 Protein; D000368:Aged; D000369:Aged, 80 and over; D020520:Brain Infarction / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D014841:von Willebrand Factor / Q000378:metabolism
D014841:von Willebrand Factor; D051722:ADAM Proteins; D000071120:ADAMTS13 Protein; C099604:ADAMTS13 protein, human