title: [The influence of the HIV pandemic on the incidence of malignant ocular tumours in Southern Malawi (Blantyre)].
abstract: BACKGROUND
  The HIV pandemic in Southeast Africa is a challenge to the poorly staffed and poorly financed health systems of the affected countries. A dramatic increase of HIV-associated ocular malignancies has been observed in Malawi. This study investigated the frequency of malignant ocular tumours at the only eye hospital in the south of Malawi.
  
  
  METHODS
  A retrospective analysis of all patients who underwent removal of conjunctival growth suspicious for malignancy was performed for the period from 1989 to 2006. In addition a consecutive group of 49 patients with malignant ocular tumours was offered an HIV test.
  
  
  RESULTS
  The number of patients undergoing surgery for suspected ocular surface squamous neoplasia (OSSN) increased from 32 cases in 1989 to 467 in 2006. Of the patients with malignant ocular tumours, 80% (39 of 49) had OSSN, and 76% of the patients with OSSN were HIV positive.
  
  
  CONCLUSIONS
  OSSN has become the most frequent malignant ocular tumour in the south of Malawi. The incidence of OSSN seems to have increased dramatically from 1989 to 2006--in parallel to increasing HIV infection rates.
authors.affiliation: Zentrum für Augenheilkunde, Universitäts-Augenklinik Tübingen, Schleichstrasse 12, Tübingen. martin.spitzer@med.uni-tuebingen.de
authors.forename: M S
authors.initials: MS
authors.lastname: Spitzer
authors.forename: T
authors.initials: T
authors.lastname: Chirambo
authors.forename: P
authors.initials: P
authors.lastname: Kayange
authors.forename: P
authors.initials: P
authors.lastname: Szurman
authors.forename: E
authors.initials: E
authors.lastname: Yoeruek
authors.forename: K U
authors.initials: KU
authors.lastname: Bartz-Schmidt
authors.forename: H N
authors.initials: HN
authors.lastname: Batumba
mesh_terms: D000293:Adolescent; D000328:Adult; D015984:Causality; D015897:Comorbidity; D004196:Disease Outbreaks / Q000706:statistics & numerical data*; D005134:Eye Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D015658:HIV Infections / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008295:Malawi / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D055815:Young Adult
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