Titanocene(III)-catalyzed formation of indolines and azaindolines.
Reductive cyclization of epoxides tethered to substituted anilines and aminopyridines in the presence of 3 mol % of titanocene dichloride and stoichiometric manganese metal promotes a radical annulation to form 3,3-disubstituted indolines and azaindolines.
Wipf
Peter
P
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA. pwipf@pitt.edu
Maciejewski
John P
JP
D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis*; D009942:Organometallic Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction
D001372:Aza Compounds; D007211:Indoles; D009942:Organometallic Compounds; C406884:titanocene; C057812:indoline
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