Role of STAT3 in inflammatory bowel disease.
Signal transducers and activators of transcription 3 (STAT3) play an important role in various autoimmune disorders including inflammatory bowel disease (IBD). Recent studies have revealed that STAT3 activation plays distinctly different roles between innate immune responses and acquired immune responses in colitis. STAT3-mediated activation of acquired immune responses plays a pathogenic role in colitis by enhancing the survival of pathogenic T cells. In contrast, STAT3-mediated activation of innate responses contributes to the suppression of colitis. This review will summarize the current understanding of the roles of STAT3 in IBD and the potential of targeting STAT3 for the treatment of IBD, emphasizing recent observations.
Sugimoto
Ken
K
Experimental Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States. sugiken@jg8.so-net.ne.jp
D006801:Humans; D007110:Immunity, Active / Q000276:immunology / Q000502:physiology; D007113:Immunity, Innate / Q000276:immunology / Q000502:physiology; D015212:Inflammatory Bowel Diseases / Q000276:immunology / Q000503:physiopathology*; D050796:STAT3 Transcription Factor / Q000502:physiology*
D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human
Science. 2001 May 11;292(5519):1115-8
11352068
Gastroenterology. 2001 Mar;120(4):925-37
11231946
J Clin Invest. 2008 Feb;118(2):534-44
18172556
Gastroenterology. 1996 Dec;111(6):1706-13
8942753
Gastroenterology. 2002 Jun;122(7):1829-41
12055591
J Clin Invest. 2004 May;113(9):1296-306
15124021
Gastroenterology. 2004 Apr;126(4):989-96; discussion 947
15057738
Annu Rev Immunol. 2002;20:495-549
11861611
Gastroenterology. 2002 Dec;123(6):1877-88
12454845
Int Immunopharmacol. 2004 May;4(5):679-91
15120652
Immunity. 2002 Feb;16(2):219-30
11869683
Am J Physiol. 1999 Sep;277(3):G495-9
10484372
Hepatology. 2004 May;39(5):1332-42
15122762
Nat Med. 2002 Oct;8(10):1089-97
12219085
Curr Opin Immunol. 1999 Dec;11(6):648-56
10631550
Inflamm Bowel Dis. 2007 Aug;13(8):1016-23
17476678
J Immunol. 2000 May 1;164(9):4878-82
10779797
Gastroenterology. 2002 Jun;122(7):2011-25
12055606
J Biol Chem. 2003 May 9;278(19):16777-81
12615922
Front Biosci. 2001 Oct 01;6:D1321-57
11578958
Gastroenterology. 2006 Nov;131(5):1501-17
17101324
Am J Gastroenterol. 2005 Jan;100(1):73-4
15654783
Gastroenterology. 1999 Jul;117(1):58-64
10381910
Mol Cell Biol. 1993 Jan;13(1):276-88
7678052
Lab Invest. 1998 Dec;78(12):1503-12
9881950
Inflamm Bowel Dis. 2005 Feb;11(2):91-8
15677901
EMBO J. 1999 Sep 1;18(17):4657-68
10469645
J Immunol. 1998 Nov 1;161(9):4652-60
9794394
Immunity. 1999 Jan;10(1):39-49
10023769
Cytokine. 2004 Apr 21;26(2):45-56
15050604
Nat Rev Mol Cell Biol. 2002 Sep;3(9):651-62
12209125
Nat Rev Immunol. 2004 May;4(5):371-9
15122202
Am J Physiol Gastrointest Liver Physiol. 2006 Apr;290(4):G827-38
16537974
Gastroenterology. 2004 May;126(6):1620-33
15168372
Inflamm Bowel Dis. 2003 Jul;9(4):246-59
12902848
Oncogene. 2000 May 15;19(21):2607-11
10851059
J Exp Med. 1996 Jul 1;184(1):241-51
8691138
J Cell Sci. 2004 Mar 15;117(Pt 8):1281-3
15020666
Hum Gene Ther. 2000 Aug 10;11(12):1731-41
10954907
Nat Med. 2002 Jun;8(6):567-73
12042806
Annu Rev Immunol. 2001;19:683-765
11244051
Immunity. 2004 Aug;21(2):241-54
15308104
Nat Med. 2008 Mar;14(3):247-9
18323844
J Exp Med. 2006 Oct 2;203(10):2271-9
16982811
Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1879-84
12571365
Postgrad Med J. 2000 Aug;76(898):473-8
10908374
N Engl J Med. 2002 Aug 8;347(6):417-29
12167685
Nature. 2007 Feb 8;445(7128):648-51
17187052
Immunity. 1995 Aug;3(2):171-4
7648390
J Exp Med. 2001 Feb 19;193(4):471-81
11181699
Immunity. 2001 Jul;15(1):149-58
11485746
J Immunol. 2002 Jul 1;169(1):460-8
12077277
Annu Rev Immunol. 2000;18:143-64
10837055
Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3801-4
9108058
Immunity. 2004 Jun;20(6):681-93
15189734
J Biol Chem. 2004 Mar 12;279(11):10304-15
14701802
N Engl J Med. 2000 Jun 1;342(22):1633-7
10833209
Nat Med. 2000 May;6(5):583-8
10802717
Am J Gastroenterol. 2005 Jan;100(1):64-72
15654782