title: Time interval in diagnosis and treatment of papillary thyroid cancer: a descriptive, retrospective study.
abstract: BACKGROUND
  Studies have investigated delays in the diagnosis of neoplasms to identify delays to treatment on the part of patients and primary care practitioners. The aim of the current study was to evaluate the time interval (TI) required for the diagnosis of symptomatic papillary thyroid carcinoma (PTC).
  
  
  METHODS
  The study included 97 patients with PTC. Other histologic types and incidental microcarcinomas were excluded. The primary outcome variable was the TI between the occurrence of a sign/symptom and thyroidectomy. TI was composed of: patient's TI (PTI), diagnostic TI (DTI), and therapeutic TI (TTI).
  
  
  RESULTS
  The TI between the occurrence of a sign/symptom and thyroidectomy averaged 3 months. PTI ranged from 25-85 days, DTI from 12-40 days, and TTI from 7-30 days. PTI was higher (P < .05) than DTI and TTI.
  
  
  CONCLUSIONS
  PTI is the most important factor affecting TI. Implementation of information may increase patient's alertness and reduce misinterpretation of signs/symptoms. Collaboration between specialists is fundamental to further reduce DTI and TTI.
authors.affiliation: Endocrine Surgery Research Center, Department of Surgical Sciences, University of Insubria, Varese, Italy. gianlorenzo.dionigi@uninsubria.it
authors.forename: Gianlorenzo
authors.initials: G
authors.lastname: Dionigi
authors.forename: Maria Laura
authors.initials: ML
authors.lastname: Tanda
authors.forename: Eliana
authors.initials: E
authors.lastname: Piantanida
authors.forename: Luigi
authors.initials: L
authors.lastname: Boni
authors.forename: Francesca
authors.initials: F
authors.lastname: Rovera
authors.forename: Renzo
authors.initials: R
authors.lastname: Dionigi
authors.forename: Luigi
authors.initials: L
authors.lastname: Bartalena
mesh_terms: D000231:Adenocarcinoma, Papillary / Q000175:diagnosis* / Q000628:therapy*; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D013965:Thyroidectomy; D013997:Time Factors; D055815:Young Adult