Gender-specific disruptions in emotion processing in younger adults with depression.
BACKGROUND
One of the principal theories regarding the biological basis of major depressive disorder (MDD) implicates a dysregulation of emotion-processing circuitry. Gender differences in how emotions are processed and relative experience with emotion processing might help to explain some of the disparities in the prevalence of MDD between women and men. This study sought to explore how gender and depression status relate to emotion processing.


METHODS
This study employed a 2 (MDD status) x 2 (gender) factorial design to explore differences in classifications of posed facial emotional expressions (N=151).


RESULTS
For errors, there was an interaction between gender and depression status. Women with MDD made more errors than did nondepressed women and men with MDD, particularly for fearful and sad stimuli (Ps <.02), which they were likely to misinterpret as angry (Ps <.04). There was also an interaction of diagnosis and gender for response cost for negative stimuli, with significantly greater interference from negative faces present in women with MDD compared to nondepressed women (P=.01). Men with MDD, conversely, performed similarly to control men (P=.61).


CONCLUSIONS
These results provide novel and intriguing evidence that depression in younger adults (<35 years) differentially disrupts emotion processing in women as compared to men. This interaction could be driven by neurobiological and social learning mechanisms, or interactions between them, and may underlie differences in the prevalence of depression in women and men.
Wright
Sara L
SL
Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, Michigan 48105, USA. sarawrig@med.umich.edu
Langenecker
Scott A
SA
Deldin
Patricia J
PJ
Rapport
Lisa J
LJ
Nielson
Kristy A
KA
Kade
Allison M
AM
Own
Lawrence S
LS
Akil
Huda
H
Young
Elizabeth A
EA
Zubieta
Jon-Kar
JK
D000223:Adaptation, Psychological; D000328:Adult; D003865:Major Depressive Disorder / Q000523:psychology*; D004192:Discrimination, Psychological; D004644:Emotions; D005149:Facial Expression; D005260:Female; D005783:Gender Identity; D006801:Humans; D008297:Male; D010364:Pattern Recognition, Visual; D011930:Reaction Time; D055815:Young Adult
J Gen Intern Med. 2001 Sep;16(9):606-13
11556941
Scand J Psychol. 2000 Sep;41(3):243-6
11041306
Emotion. 2004 Jun;4(2):201-6
15222856
Psychol Bull. 1996 Sep;120(2):163-88
8831295
Neuroreport. 2004 Feb 9;15(2):219-23
15076740
Scand J Psychol. 2002 Apr;43(2):123-30
12004949
J Pers Soc Psychol. 1995 Jul;69(1):176-90
7643299
Psychiatry Res. 1998 Jun 2;79(1):59-72
9676828
Neuropsychology. 2002 Jan;16(1):102-10
11853351
Psychiatry Res. 1992 Jun;42(3):241-51
1496056
Psychiatry Res. 2007 Aug 30;152(2-3):143-54
17445911
J Abnorm Psychol. 1991 Nov;100(4):569-82
1757671
J Abnorm Psychol. 1993 Aug;102(3):358-68
8408947
Ann N Y Acad Sci. 1999 Jun 29;877:614-37
10415674
Psychol Bull. 1994 May;115(3):424-43
8016286
J Pers Soc Psychol. 1999 Nov;77(5):1061-72
10573880
Biol Psychiatry. 1996 Nov 1;40(9):859-71
8896772
Cogn Neuropsychiatry. 2006 May;11(3):250-71
17354071
J Soc Psychol. 1991 Dec;131(6):815-22
1816467
Clin Psychol Rev. 1999 Aug;19(5):553-70
10467491
Soc Sci Med. 2006 May;62(9):2246-57
16289741
J Pers Soc Psychol. 1998 Jul;75(1):166-77
9686457
J Affect Disord. 1986 Jul-Aug;11(1):43-50
2944927
Am J Psychiatry. 2002 Jul;159(7):1133-45
12091191
Cogn Process. 2005 Jun;6(2):136-41
18219511
J Clin Exp Neuropsychol. 2005 Apr;27(3):320-33
15969355
Biol Psychiatry. 1996 Oct 15;40(8):697-705
8894061
J Pers Soc Psychol. 1998 Mar;74(3):686-703
9523412
Biol Psychiatry. 1992 May 1;31(9):947-53
1637932