title: Stereoselective syntheses of the C(1)-C(9) fragment of amphidinolide C.
abstract: Stereoselective syntheses of the C(1)-C(9) fragments 18 and 28 of amphidinolide C have been developed. The first-generation sequence involves a diastereoselective chelate-controlled [3 + 2]-annulation reaction of 6 and 7, while the second-generation synthesis involves an intramolecular hetero-Michael cyclization of 8.
authors.affiliation: Department of Chemistry, Scripps Florida, Jupiter, Florida 33458, USA.
authors.forename: Robert H
authors.initials: RH
authors.lastname: Bates
authors.forename: J Brad
authors.initials: JB
authors.lastname: Shotwell
authors.forename: William R
authors.initials: WR
authors.lastname: Roush
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D006801:Humans; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D051379:Mice; D013237:Stereoisomerism; D013379:Substrate Specificity; D000097442:Amphidinolides
chemical_list: D018942:Macrolides; C429132:amphidinolide C; D000097442:Amphidinolides
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