Caspofungin-resistant Candida tropicalis strains causing breakthrough fungemia in patients at high risk for hematologic malignancies.
We identified three cases of C. tropicalis strains causing breakthrough fungemia in allogeneic stem cell recipients receiving caspofungin prophylaxis and treatment. Three genetically unrelated isolates with high echinocandin MICs were identified. Each strain carried a characteristic mutation conferring an amino acid substitution within Fks1p hot spot 1.
Garcia-Effron
Guillermo
G
Public Health Research Institute, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey , USA.
Kontoyiannis
Dimitrios P
DP
Lewis
Russell E
RE
Perlin
David S
DS
D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000494:pharmacology*; D041022:Candida tropicalis / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D002177:Candidiasis / Q000382:microbiology / Q000517:prevention & control*; D000077336:Caspofungin; D025141:Drug Resistance, Fungal; D054714:Echinocandins / Q000494:pharmacology*; D016469:Fungemia / Q000382:microbiology / Q000517:prevention & control*; D019337:Hematologic Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology*; D006801:Humans; D055666:Lipopeptides; D008297:Male; D008875:Middle Aged
D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077336:Caspofungin
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