Chiral phosphonate internucleotide linkage: a promising modification for chimeric oligonucleotides?
We have synthesized two different groups of oligonucleotides containing chiral isopolar nonisosteric phosphonate internucleotide linkages, and studied their properties in combination with natural phosphodiester ones. The improved synthetic procedures for the monomers preparation are also reported.
Liboska
Radek
R
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo n. 2, 166 10 Prague, Czech Republic.
Petrová
Magdalena
M
Pohl
Radek
R
Budesínsky
Milos
M
Hurychová
Vladimíra
V
Rosenberg
Ivan
I
D004247:DNA / Q000737:chemistry; D004722:Endoribonucleases / Q000737:chemistry; D007536:Isomerism; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D063065:Organophosphonates / Q000737:chemistry*; D012313:RNA / Q000737:chemistry
D009838:Oligodeoxyribonucleotides; D063065:Organophosphonates; D012313:RNA; D004247:DNA; D004722:Endoribonucleases; C031956:2-5A-dependent ribonuclease