Resistin in human colorectal cancer: increased expression independently of resistin promoter -420C > G genotype.
A single nucleotide polymorphism (SNP) -420C > G of the resistin gene was screened in 248 colorectal cancer (CRC) patients and 256 controls. No significant difference in genotype distribution was found. However, we found an upregulation in 92% of the samples in the levels of resistin protein in cancer tissue (n = 83). Immunohistochemical analysis revealed heterogenous staining of resistin predominantly in the cancer tissue. Further, resistin induced secretion of MMP-2 and MMP-9 from monocytes. The results of this study suggest that resistin may play a partial role in CRC but that the -420C > G resistin polymorphism is not a potential genetic susceptibility factor.
Wågsater
Dick
D
Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institute, Stockholm, Sweden. Dick.Wagsater@ki.se
Mumtaz
Melad
M
Lofgren
Sture
S
Hugander
Anders
A
Dimberg
Jan
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005838:Genotype; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000235:genetics; D008875:Middle Aged; D011401:Promoter Regions, Genetic; D052243:Resistin / Q000235:genetics*; D013548:Sweden
D052243:Resistin