title: Tracheobronchopathia osteochondroplastica: a rare large airway disorder.
abstract: Tracheobronchopathia osteochondroplastica (TO) is a rare disorder of the large airways characterized by the development of submucosal cartilaginous and bony nodules. The nodules involve the anterior and lateral walls and typically spare the posterior membranous wall. The clinical presentation of TO is variable and ranges from incidental diagnosis in asymptomatic patients during workup or management for unrelated medical problems, to devastating disease with central airway obstruction. Bronchoscopy remains the gold standard for diagnosing this condition. Radiographic studies play an important role in suggesting the diagnosis of TO and in the follow-up of this condition. The treatment of TO is usually symptomatic. with emphasis on the management and prevention of recurrent respiratory infections. Bronchoscopic or surgical treatment is usually reserved for symptomatic patients with severe airway narrowing and airflow obstruction.
authors.affiliation: Department of Medicine, The Warren Alpert Medical School, Brown University, Providence, RI 02912, USA. Muhanned_Abu-Hijleh@brown.edu
authors.forename: Muhanned
authors.initials: M
authors.lastname: Abu-Hijleh
authors.forename: David
authors.initials: D
authors.lastname: Lee
authors.forename: Sidney S
authors.initials: SS
authors.lastname: Braman
mesh_terms: D000402:Airway Obstruction / Q000000981:diagnostic imaging*; D001982:Bronchial Diseases / Q000175:diagnosis* / Q000628:therapy; D001999:Bronchoscopy; D002357:Cartilage Diseases / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D010009:Osteochondrodysplasias / Q000175:diagnosis* / Q000628:therapy; D014057:Tomography, X-Ray Computed; D014133:Tracheal Diseases / Q000175:diagnosis* / Q000628:therapy
references.citation: AJR Am J Roentgenol. 2001 Mar;176(3):713-7
references.pmid: 11222211
references.citation: Radiology. 1958 Dec;71(6):847-50
references.pmid: 13624038
references.citation: Chest. 1981 Dec;80(6):706-9
references.pmid: 7307593
references.citation: Eur Respir J. 2007 Dec;30(6):1138-42
references.pmid: 17928312
references.citation: Medicine (Baltimore). 2001 Nov;80(6):378-90
references.pmid: 11704714
references.citation: Riv Anat Patol Oncol. 1957 Sep;13(2):188-208
references.pmid: 13543201
references.citation: Lung. 2008 Sep-Oct;186(5):293-7
references.pmid: 18463923
references.citation: Eur J Cardiothorac Surg. 2002 Jan;21(1):140-2
references.pmid: 11788286
references.citation: Ann Thorac Surg. 2005 May;79(5):1676-81
references.pmid: 15854953
references.citation: Australas Radiol. 2005 Aug;49(4):319-21
references.pmid: 16097076
references.citation: Pathology. 1982 Oct;14(4):429-33
references.pmid: 6818508
references.citation: Acta Otolaryngol. 1960 Jan-Feb;51:79-83
references.pmid: 14407149
references.citation: Acta Otolaryngol. 1977 Jul-Aug;84(1-2):118-23
references.pmid: 409093
references.citation: Br J Radiol. 1990 Jan;63(745):31-2
references.pmid: 2306585
references.citation: Respir Med. 1997 Sep;91(8):499-502
references.pmid: 9338055
references.citation: Otolaryngol Head Neck Surg. 1997 Dec;117(6):S102-4
references.pmid: 9419117
references.citation: Chest. 1972 May;61(5):465-8
references.pmid: 5046845
references.citation: Eur J Respir Dis. 1983 Feb;64(2):129-33
references.pmid: 6832250
references.citation: Virchows Arch. 1997 Nov;431(5):359-63
references.pmid: 9463578
references.citation: Pediatr Pulmonol. 2006 Jan;41(1):95-7
references.pmid: 16284968
references.citation: Chest. 1990 Mar;97(3):763
references.pmid: 2306984
references.citation: Ann Otol Rhinol Laryngol. 1990 Sep;99(9 Pt 1):689-94
references.pmid: 2118745
references.citation: Br J Dis Chest. 1977 Oct;71(4):268-72
references.pmid: 588428
references.citation: Thorax. 1968 Jan;23(1):105-10
references.pmid: 4966103
references.citation: Prax Klin Pneumol. 1979 Oct;33(10):1060-3
references.pmid: 537993
references.citation: Am J Respir Crit Care Med. 2004 May 15;169(10):1096-102
references.pmid: 15132959
references.citation: J Pathol. 1982 Nov;138(3):235-9
references.pmid: 7131135
references.citation: Br J Anaesth. 2001 Sep;87(3):515-7
references.pmid: 11517145
references.citation: J Laryngol Otol. 1985 Mar;99(3):305-10
references.pmid: 3919129
references.citation: Semin Respir Crit Care Med. 2002 Apr;23(2):167-75
references.pmid: 16088609
references.citation: Arch Otolaryngol Head Neck Surg. 1995 Oct;121(10):1162-6
references.pmid: 7546585
references.citation: J Clin Pathol. 1967 Nov;20(6):814-20
references.pmid: 4972990
references.citation: J Comput Assist Tomogr. 2002 Jan-Feb;26(1):33-6
references.pmid: 11801902
references.citation: J Thorac Cardiovasc Surg. 2006 Sep;132(3):714-6
references.pmid: 16935146
references.citation: Am J Med. 1964 May;36:815-8
references.pmid: 14141456