RAPping production of type I interferon in pDCs through mTOR.
The production of type I interferon -- the first line of defense against virus infection and critical for innate immunity -- in plasmacytoid dendritic cells relies on the mammalian target of rapamycin.
Costa-Mattioli
Mauro
M
Department of Biochemistry and the McGill Cancer Centre, McGill University, Montreal, Quebec, Canada.
Sonenberg
Nahum
N
D000818:Animals; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007370:Interferon Type I / Q000096:biosynthesis*; D011494:Protein Kinases / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*; D058570:TOR Serine-Threonine Kinases
D007370:Interferon Type I; D011494:Protein Kinases; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases