title: Association of longer telomeres with better health in centenarians.
abstract: Prior animal model studies have demonstrated an association between telomere length and longevity. Our study examines telomere length in centenarians in good health versus poor health. Using DNA from blood lymphocytes, telomere length was measured by quantitative polymerase chain reaction in 38 sex- and age-matched centenarians (ages 97-108). "Healthy" centenarians (n = 19) with physical function in the independent range and the absence of hypertension, congestive heart failure, myocardial infarction, peripheral vascular disease, dementia, cancer, stroke, chronic obstructive pulmonary disease, and diabetes were compared to centenarians with physical function limitations and > or =2 of the above conditions (n = 19). Healthy centenarians had significantly longer telomeres than did unhealthy centenarians (p =.0475). Our study demonstrated that investigations of the association between telomere length and exceptional longevity must take into account the health status of the individuals. This raises the possibility that perhaps it is not exceptional longevity but one's function and health that may be associated with telomere length.
authors.affiliation: New England Centenarian Study, Geriatrics Section of the Department of Medicine, Boston Medical Center, Boston University School of Medicine, 88 East Newton Street, Boston, MA 02118, USA. laterry@bu.edu
authors.forename: Dellara F
authors.initials: DF
authors.lastname: Terry
authors.forename: Vikki G
authors.initials: VG
authors.lastname: Nolan
authors.forename: Stacy L
authors.initials: SL
authors.lastname: Andersen
authors.forename: Thomas T
authors.initials: TT
authors.lastname: Perls
authors.forename: Richard
authors.initials: R
authors.lastname: Cawthon
mesh_terms: D000203:Activities of Daily Living; D000369:Aged, 80 and over / Q000502:physiology*; D005260:Female; D006304:Health Status; D006801:Humans; D008136:Longevity / Q000502:physiology*; D008297:Male; D016615:Telomere / Q000648:ultrastructure
references.citation: Md State Med J. 1965 Feb;14:61-5
references.pmid: 14258950
references.citation: Lancet. 2004 Feb 14;363(9408):507-10
references.pmid: 14975611
references.citation: Int J Epidemiol. 2006 Dec;35(6):1424-9
references.pmid: 16997848
references.citation: Epidemiology. 2006 Mar;17(2):190-4
references.pmid: 16477260
references.citation: Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12135-9
references.pmid: 17623782
references.citation: J Gerontol A Biol Sci Med Sci. 2003 Mar;58(3):232-7
references.pmid: 12634289
references.citation: Neurobiol Aging. 2003 Jan-Feb;24(1):77-84
references.pmid: 12493553
references.citation: Arterioscler Thromb Vasc Biol. 2003 May 1;23(5):842-6
references.pmid: 12649083
references.citation: J Gerontol A Biol Sci Med Sci. 2006 Aug;61(8):871-3
references.pmid: 16912107
references.citation: Arch Intern Med. 2008 Feb 11;168(3):277-83
references.pmid: 18268168
references.citation: Cell. 1999 Mar 5;96(5):701-12
references.pmid: 10089885
references.citation: Hypertension. 2001 Feb;37(2 Pt 2):381-5
references.pmid: 11230304
references.citation: Lancet. 2001 Aug 11;358(9280):472-3
references.pmid: 11513915
references.citation: Nucleic Acids Res. 2002 May 15;30(10):e47
references.pmid: 12000852
references.citation: Nat Genet. 2004 Jun;36(6):607-11
references.pmid: 15122256
references.citation: Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16374-8
references.pmid: 16258070
references.citation: Exp Cell Res. 1965 Mar;37:614-36
references.pmid: 14315085
references.citation: Lancet. 2003 Feb 1;361(9355):393-5
references.pmid: 12573379
references.citation: Ann Neurol. 2006 Aug;60(2):181-7
references.pmid: 16807921
references.citation: Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17312-5
references.pmid: 15574496
references.citation: Aging Cell. 2006 Aug;5(4):325-30
references.pmid: 16913878
references.citation: Hypertension. 2004 Feb;43(2):182-5
references.pmid: 14732735
references.citation: Aging Cell. 2005 Dec;4(6):287-90
references.pmid: 16300480