title: Click chemistry and oligonucleotides: how a simple reaction can do so much.
abstract: Copper catalyzed Alkyne Azide 1,3-dipolar cycloaddition (CuAAC) "click reaction" was applied for the construction of oligonucleotide conjugates, circular objects and phosphodiester glyco-clusters. To this end, several strategies were developed to introduce either alkyne or azide functions into an oligonucleotide.
authors.affiliation: IBMM, UMR5247 CNRS Université Montpellier 1, Université Montpellier 2, Place E. Bataillon, CC1704, 34095 Montpellier Cedex 5, France. morvan@univ-montp2.fr
authors.forename: François
authors.initials: F
authors.lastname: Morvan
authors.forename: Albert
authors.initials: A
authors.lastname: Meyer
authors.forename: Gwladys
authors.initials: G
authors.lastname: Pourceau
authors.forename: Sébastien
authors.initials: S
authors.lastname: Vidal
authors.forename: Yann
authors.initials: Y
authors.lastname: Chevolot
authors.forename: Eliane
authors.initials: E
authors.lastname: Souteyrand
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Vasseur
mesh_terms: D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D002241:Carbohydrates / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D009841:Oligonucleotides / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000737:chemistry; D010455:Peptides / Q000737:chemistry
chemical_list: D000480:Alkynes; D001386:Azides; D002241:Carbohydrates; D009841:Oligonucleotides; D009943:Organophosphorus Compounds; D010455:Peptides; C434331:phosphoramidite; D003300:Copper