Transmission of different strains of Plasmodium cynomolgi to Aotus nancymaae monkeys and relapse.
Forty-four splenectomized Aotus nancymaae monkeys were infected with 6 different strains of Plasmodium cynomolgi, 11 via trophozoites and 33 via sporozoites. Sporozoites from Anopheles dirus, Anopheles freeborni, Anopheles gambiae, Anopheles maculatus, and Anopheles stephensi resulted in prepatent periods ranging from 9 to 39 days (median of 15 days). Importantly, relapse was demonstrated in 5 of 5 sporozoite-induced infections with the Rossan strain following treatment with chloroquine.
Collins
William E
WE
National Center for Zoonotic, Vector-Borne and Enteric Diseases, and Animal Resources Branch, Natl. Center for Preparedness, Detection and Control of Infectious Diseases, CDC, U.S. PHS, DHHS, Atlanta, Georgia 30341, USA. wec1@cdc.gov
Sullivan
JoAnn S
JS
Nace
Douglas
D
Williams
Tyrone
T
Williams
Allison
A
Barnwell
John W
JW
D000818:Animals; D000852:Anopheles / Q000469:parasitology; D000962:Antimalarials / Q000627:therapeutic use; D016645:Aotidae / Q000469:parasitology*; D002738:Chloroquine / Q000627:therapeutic use; D007303:Insect Vectors / Q000469:parasitology; D008288:Malaria / Q000188:drug therapy / Q000469:parasitology / Q000635:transmission / Q000662:veterinary*; D008992:Monkey Diseases / Q000188:drug therapy / Q000469:parasitology* / Q000635:transmission; D018512:Parasitemia / Q000469:parasitology / Q000635:transmission; D016789:Plasmodium cynomolgi / Q000145:classification / Q000502:physiology*; D012008:Recurrence
D000962:Antimalarials; D002738:Chloroquine