Finding genes underlying human disease.
With the surge in genome-wide association studies (GWAS), many have asked the question 'Are linkage studies dead?' In this article, we survey the approaches used in mapping human disease genes, reviewing the analysis strategies that preceded and laid the groundwork for GWAS. We note that earlier approaches are still useful and the development of new methodology is warranted.
Stein
C M
CM
Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA. cmstein@cwru.edu
Elston
R C
RC
D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D014644:Genetic Variation; D015894:Genome, Human; D055106:Genome-Wide Association Study / Q000379:methods* / Q000706:statistics & numerical data / Q000639:trends; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide
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