Generation of effective vaccines against liver cancer by using photodynamic therapy.
Preclinical studies have shown that photodynamic therapy (PDT) enhances immune responses. To examine the role of the direct effects of PDT in liver cancer with regard to enhancement of the antitumor response, we injected PDT-generated H22 liver cancer cell lysate (as a tumor vaccine) intradermally into Kunming mice. In the control group, the cell lysate was substituted with normal saline solution. A liver tumor model was established by the injection of H22 cell suspension. We found that the PDT-generated vaccine significantly increased the percentages of CD4(+), CD8(+), and CD19(+) cells, inhibited tumor growth, and prolonged the survival time. Our findings suggest that PDT-generated vaccines can significantly enhance the antitumor immune response and may have the potential to be used as an adjuvant therapy clinically.
Zhang
Hongyu
H
Laser Medicine Laboratory of Tianjin Medical University, Tianjin, PR China.
Ma
Wenjiang
W
Li
Yingxin
Y
D000818:Animals; D019496:Cancer Vaccines / Q000302:isolation & purification* / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D003131:Combined Modality Therapy; D005260:Female; D007111:Immunity, Cellular; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D028022:Low-Level Light Therapy; D016131:Lymphocyte Subsets / Q000276:immunology; D008297:Male; D051379:Mice; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use
D019496:Cancer Vaccines; D017319:Photosensitizing Agents
Cancer Res. 1999 Apr 15;59(8):1941-6
10213504
Cancer Res. 2005 Feb 1;65(3):1018-26
15705903
Cancer Immunol Immunother. 2006 Aug;55(8):900-9
16215717
Cancer Res. 2002 Mar 15;62(6):1604-8
11912128
Anticancer Res. 2000 Jul-Aug;20(4):2665-76
10953341
World J Gastroenterol. 2004 Mar 1;10(5):630-3
14991927
Br J Cancer. 2003 Jun 2;88(11):1772-9
12771994
J Natl Cancer Inst. 1998 Jun 17;90(12):889-905
9637138
Cell. 2001 Aug 10;106(3):271-4
11509176
Cancer Lett. 2002 Sep 8;183(1):43-51
12049813