title: Intercellular adhesion molecule-1 gene K469E polymorphism and ischemic stroke: a case-control study in a Chinese population.
abstract: BACKGROUND
  Intercellular adhesion molecule-1 (ICAM-1) was involved in the pathogenetic mechanisms responsible for ischemic stroke (IS). Population-based sample have revealed gene-gender interaction in blood pressure which is major risk for IS. We sought to evaluate whether ICAM-1 K469E polymorphism was involved in the causation of IS and whether it was different between female and male.
  
  
  METHODS
  A 1:1 case-control study was conducted. The K469E polymorphism of ICAM-1 gene were analyzed by polymerase chain reaction (PCR) and restriction enzyme analysis in Chinese patients with IS (n = 309) and elderly subjects without IS (n = 309).
  
  
  RESULTS
  ICAM-1 K469E polymorphism was significantly associated with IS. Interestingly, a further analysis stratified by sex found that there was significance between 469E genotypes and IS in female, but not in male. Multiple regression analysis revealed that ICAM-1 K469E polymorphism was still significantly associated with IS, compared with ICAM-1 KK genotype in all population (OR = 1.60, P = 0.030). Stratified by sex, EE combined EK was contributory factor to IS in female (OR = 3.03, P = 0.004), but not in male. After adjustment for confounding factors, the interaction between female and ICAM-1 EK/EE genotypes was found (OR = 3.54, P = 0.001).
  
  
  CONCLUSIONS
  It is suggested that the ICAM-1 469E allele may be important in the pathogenesis of ischemic stroke, especially in female but not in male.
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei, 430030, China.
authors.forename: Xiao Xia
authors.initials: XX
authors.lastname: Li
authors.forename: Jian Ping
authors.initials: JP
authors.lastname: Liu
authors.forename: Jin Quan
authors.initials: JQ
authors.lastname: Cheng
authors.forename: Sheng Hong
authors.initials: SH
authors.lastname: Han
authors.forename: Yi Jie
authors.initials: YJ
authors.lastname: Geng
authors.forename: Sheng
authors.initials: S
authors.lastname: Wei
authors.forename: Shi Tong
authors.initials: ST
authors.lastname: Gao
authors.forename: Da Na
authors.initials: da N
authors.lastname: Huang
authors.forename: Shao Fa
authors.initials: SF
authors.lastname: Nie
mesh_terms: D000368:Aged; D019943:Amino Acid Substitution; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D005838:Genotype; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012737:Sex Factors; D020521:Stroke / Q000235:genetics*
chemical_list: D018799:Intercellular Adhesion Molecule-1
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