title: Proteomics of human neurodegenerative diseases.
abstract: The technology, experimental approaches, and bioinformatics that support proteomic research are evolving rapidly. The application of these new capabilities to the study of neurodegenerative diseases is providing insight into the biochemical pathogenesis of neurodegeneration as well as fueling major efforts in biomarker discovery. Here, we review the fundamentals of commonly used proteomic approaches and the outcomes of these investigations with autopsy and cerebrospinal fluid samples from patients with neurodegenerative diseases.
authors.affiliation: Department of Pathology, University of Washington, Harborview Medical Centre, Seattle, Washington 98104, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: C Dirk
authors.initials: CD
authors.lastname: Keene
authors.forename: Catherine
authors.initials: C
authors.lastname: Pan
authors.forename: Kathleen S
authors.initials: KS
authors.lastname: Montine
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Montine
mesh_terms: D001921:Brain / Q000473:pathology; D001923:Brain Chemistry / Q000235:genetics; D006801:Humans; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000235:genetics; D019636:Neurodegenerative Diseases / Q000134:cerebrospinal fluid / Q000235:genetics* / Q000473:pathology; D011506:Proteins / Q000737:chemistry; D040901:Proteomics / Q000379:methods*
chemical_list: D009419:Nerve Tissue Proteins; D011506:Proteins
references.citation: J Biol Chem. 2004 Mar 26;279(13):13256-64
references.pmid: 14722078
references.citation: Methods Enzymol. 2008;440:295-308
references.pmid: 18423226
references.citation: Microsc Res Tech. 2001 Jan 1;52(1):31-7
references.pmid: 11135446
references.citation: Free Radic Biol Med. 2002 Aug 15;33(4):562-71
references.pmid: 12160938
references.citation: Clin Chem. 2005 Feb;51(2):336-45
references.pmid: 15563479
references.citation: Annu Rev Pathol. 2006;1:151-70
references.pmid: 18039111
references.citation: FEBS Lett. 2006 Oct 30;580(25):5807-14
references.pmid: 17027006
references.citation: Electrophoresis. 2004 Jul;25(14):2402-12
references.pmid: 15274023
references.citation: Clin Chem. 2007 May;53(5):852-8
references.pmid: 17395711
references.citation: Am J Clin Pathol. 2008 Apr;129(4):526-9
references.pmid: 18343778
references.citation: J Proteome Res. 2005 Mar-Apr;4(2):358-68
references.pmid: 15822911
references.citation: Brain Res Mol Brain Res. 2003 Oct 21;118(1-2):140-6
references.pmid: 14559363
references.citation: Mol Cell Proteomics. 2005 Dec;4(12):2000-9
references.pmid: 16199891
references.citation: J Proteome Res. 2004 Jan-Feb;3(1):97-103
references.pmid: 14998169
references.citation: Expert Rev Mol Diagn. 2005 Sep;5(5):661-72
references.pmid: 16149870
references.citation: Neurobiol Aging. 2005 Feb;26(2):207-27
references.pmid: 15582749
references.citation: J Alzheimers Dis. 2005 Mar;8(4):339-46
references.pmid: 16556965
references.citation: Neuropathology. 2007 Oct;27(5):494-506
references.pmid: 18018486
references.citation: Electrophoresis. 2004 Aug;25(15):2564-75
references.pmid: 15300777
references.citation: Curr Opin Mol Ther. 2005 Dec;7(6):557-64
references.pmid: 16372405
references.citation: Am J Pathol. 2007 Sep;171(3):993-1002
references.pmid: 17675576
references.citation: Brain Res. 2007 May 7;1148:243-8
references.pmid: 17395167
references.citation: J Proteome Res. 2006 Oct;5(10):2769-79
references.pmid: 17022648
references.citation: J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Feb 15;847(1):12-23
references.pmid: 17118720
references.citation: Ann Neurol. 2006 Feb;59(2):237-47
references.pmid: 16437581
references.citation: Biochem Biophys Res Commun. 1984 May 16;120(3):885-90
references.pmid: 6375662
references.citation: FASEB J. 2006 Jul;20(9):1473-83
references.pmid: 16816122
references.citation: Proteomics. 2004 Dec;4(12):4010-8
references.pmid: 15540204
references.citation: Expert Rev Mol Diagn. 2006 May;6(3):387-98
references.pmid: 16706741
references.citation: Methods Mol Biol. 2008;439:241-56
references.pmid: 18370108
references.citation: Proteomics. 2001 Dec;1(12):1519-28
references.pmid: 11747211
references.citation: Exp Gerontol. 2007 Apr;42(4):263-74
references.pmid: 17188442
references.citation: Pain. 2003 Apr;102(3):251-6
references.pmid: 12670666
references.citation: Am J Pathol. 1998 Apr;152(4):879-84
references.pmid: 9546347
references.citation: Dis Markers. 2005;21(2):81-92
references.pmid: 15920295
references.citation: J Alzheimers Dis. 2006 Aug;9(3):293-348
references.pmid: 16914840
references.citation: Neurosurg Clin N Am. 2001 Oct;12(4):631-8, vii
references.pmid: 11524285
references.citation: FASEB J. 2005 May;19(7):869-71
references.pmid: 15746184
references.citation: J Alzheimers Dis. 2005 Apr;7(2):125-33; discussion 173-80
references.pmid: 15851850
references.citation: Exp Neurol. 2005 Dec;196(2):273-81
references.pmid: 16154129
references.citation: Proteomics. 2003 Aug;3(8):1486-94
references.pmid: 12923774
references.citation: Biochemistry. 2005 Mar 1;44(8):2885-99
references.pmid: 15723531
references.citation: Neurology. 2006 Apr 25;66(8):1218-22
references.pmid: 16481598
references.citation: Mol Cell Proteomics. 2006 Jul;5(7):1193-204
references.pmid: 16565515
references.citation: Int Rev Neurobiol. 2006;73:29-98
references.pmid: 16737901
references.citation: Brain Res. 2003 Mar 28;967(1-2):152-60
references.pmid: 12650976
references.citation: Eur J Clin Chem Clin Biochem. 1995 Jan;33(1):53-8
references.pmid: 7756441
references.citation: J Alzheimers Dis. 2001 Feb;3(1):117-119
references.pmid: 12214080
references.citation: J Neurosurg. 1983 Sep;59(3):369-83
references.pmid: 6886750
references.citation: Proteomics. 2004 Aug;4(8):2229-33
references.pmid: 15274116
references.citation: Am J Pathol. 2002 May;160(5):1725-31
references.pmid: 12000724
references.citation: Am J Physiol. 1992 Jan;262(1 Pt 2):R20-4
references.pmid: 1733335
references.citation: Ann Neurol. 2007 Feb;61(2):120-9
references.pmid: 17167789
references.citation: Brain Pathol. 2007 Apr;17(2):139-45
references.pmid: 17388944
references.citation: Electrophoresis. 2000 Jun;21(11):2266-83
references.pmid: 10892737
references.citation: Proteomics. 2005 Aug;5(12):3060-5
references.pmid: 16021609
references.citation: Proteomics. 2006 Dec;6(23):6326-53
references.pmid: 17083142
references.citation: Proteomics. 2006 Apr;6(7):2305-13
references.pmid: 16552785
references.citation: Eur Neurol. 1993;33(2):134-42
references.pmid: 8467820
references.citation: Dis Markers. 2006;22(1-2):3-26
references.pmid: 16410649
references.citation: J Biol Chem. 2004 Aug 27;279(35):37061-8
references.pmid: 15220353
references.citation: J Neuropathol Exp Neurol. 2008 Feb;67(2):117-24
references.pmid: 18219256
references.citation: J Biol Chem. 2004 Jun 18;279(25):26685-97
references.pmid: 15060066
references.citation: J Neurochem. 2002 Sep;82(6):1524-32
references.pmid: 12354300
references.citation: Anal Chem. 2005 Jul 15;77(14):4626-39
references.pmid: 16013882
references.citation: Nat Methods. 2007 Oct;4(10):828-33
references.pmid: 17901873
references.citation: J Proteome Res. 2008 Feb;7(2):720-30
references.pmid: 18186601
references.citation: Arch Neurol. 2007 Mar;64(3):366-70
references.pmid: 17353378
references.citation: Acta Neuropathol. 2004 Jun;107(6):497-503
references.pmid: 15024581
references.citation: Neurology. 2006 Jul 11;67(1):64-8
references.pmid: 16832079
references.citation: Mol Cell Proteomics. 2004 Dec;3(12):1154-69
references.pmid: 15385600
references.citation: Dement Geriatr Cogn Disord. 2007;24(6):434-40
references.pmid: 17971664
references.citation: Biochim Biophys Acta. 1999 Dec 27;1473(2-3):391-9
references.pmid: 10594376
references.citation: Science. 1991 Feb 8;251(4994):675-8
references.pmid: 1899488
references.citation: Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15688-93
references.pmid: 15507493
references.citation: Neurol Res. 2006 Mar;28(2):155-63
references.pmid: 16551433
references.citation: J Chromatogr B Analyt Technol Biomed Life Sci. 2002 May 5;771(1-2):167-96
references.pmid: 12015998
references.citation: Anal Chem. 2003 Feb 15;75(4):768-74
references.pmid: 12622365
references.citation: Nat Biotechnol. 1999 Oct;17(10):994-9
references.pmid: 10504701
references.citation: Eur Neurol. 1993;33(2):129-33
references.pmid: 8467819
references.citation: Mol Cell Proteomics. 2002 Apr;1(4):323-33
references.pmid: 12096114
references.citation: Science. 2001 May 4;292(5518):929-34
references.pmid: 11340206
references.citation: J Neuropathol Exp Neurol. 2000 Jul;59(7):585-91
references.pmid: 10901229
references.citation: FASEB J. 2005 Nov;19(13):1923-5
references.pmid: 16129700
references.citation: Eur Neurol. 1993;33(2):126-8
references.pmid: 8467818
references.citation: FASEB J. 2005 Dec;19(14):2060-2
references.pmid: 16186172
references.citation: J Alzheimers Dis. 2007 May;11(2):153-64
references.pmid: 17522440
references.citation: Otolaryngol Clin North Am. 2005 Aug;38(4):569-76
references.pmid: 16005717
references.citation: Med Clin North Am. 2002 May;86(3):591-614
references.pmid: 12171060
references.citation: Proteomics. 2004 Dec;4(12):3943-52
references.pmid: 15526345
references.citation: Cell Mol Life Sci. 2000 Nov;57(12):1810-6
references.pmid: 11130185
references.citation: J Biol Chem. 2006 Apr 21;281(16):10825-38
references.pmid: 16443603
references.citation: J Neurochem. 2005 Dec;95(5):1461-71
references.pmid: 16313519
references.citation: J Am Soc Mass Spectrom. 1994 Nov;5(11):976-89
references.pmid: 24226387
references.citation: Acta Neuropathol. 2006 May;111(5):401-12
references.pmid: 16609851
references.citation: Neuroreport. 2002 Apr 16;13(5):611-5
references.pmid: 11973456
references.citation: Neurology. 2007 Mar 13;68(11):812-9
references.pmid: 17353469
references.citation: J Cell Mol Med. 2007 Jul-Aug;11(4):839-51
references.pmid: 17760844
references.citation: J Alzheimers Dis. 2004 Jun;6(3):257-68
references.pmid: 15201480