title: Acute mountain sickness in a subject with metabolic syndrome at high altitude.
abstract: Visitors at high altitude are increasing in age and comorbidities, which can lead to a failure in acclimatization. We describe the development of acute mountain sickness (AMS) in a 44-year-old man with metabolic syndrome and the time- and altitude-dependent correlation between the development of AMS and blood pressure and heart rate changes. Our observations support a dominant role of endothelial dysfunction in the pathogenesis of AMS and suggest new behavioral indications.
authors.affiliation: Department of Clinical and Experimental Medicine, University of Padova, Italy. giacomo.strapazzon@unipd.it
authors.forename: Giacomo
authors.initials: G
authors.lastname: Strapazzon
authors.forename: Annalisa
authors.initials: A
authors.lastname: Cogo
authors.forename: Andrea
authors.initials: A
authors.lastname: Semplicini
mesh_terms: D000208:Acute Disease; D000328:Adult; D000532:Altitude Sickness / Q000209:etiology*; D001794:Blood Pressure / Q000502:physiology; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications*; D009051:Mountaineering; D009390:Nepal; D010100:Oxygen / Q000378:metabolism; D010101:Oxygen Consumption / Q000502:physiology
chemical_list: D010100:Oxygen