title: Evolutionary steps of sex chromosomes are reflected in retrogenes.
abstract: It has been shown that selective pressure to compensate for the silencing of the sex chromosomes during male meiosis resulted in many X-linked genes being duplicated as functional retrogenes on autosomes. The silencing of male sex chromosomes was probably stratified during evolution, in accordance with their stratified diversification. Here I show that the timing of the retrocopying events is associated with the timing of the X-Y differentiation of the region of the X chromosome housing the parental copy of the gene.
authors.affiliation: Smurfit Institute of Genetics, University of Dublin, Trinity College, Dublin, Ireland. aoife.mclysaght@tcd.ie
authors.forename: Aoife
authors.initials: A
authors.lastname: McLysaght
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D050172:Genes, X-Linked / Q000502:physiology; D006801:Humans; D008322:Mammals / Q000235:genetics; D008954:Models, Biological; D010802:Phylogeny; D018626:Retroelements / Q000235:genetics*; D012730:Sex Chromosomes / Q000235:genetics*
chemical_list: D018626:Retroelements