BCL6 expression correlates with monomorphic histology in children with posttransplantation lymphoproliferative disease.
Posttransplantation lymphoproliferative disease (PTLD) is a complication of organ transplantation with high mortality. Predicting response to first-line therapy, reduction of immune suppression, is difficult because of the heterogeneity of lesions and disease behavior. We sought to determine if BCL6 protein expression in PTLD cells is associated with poor outcome. In a cohort of 25 children with PTLD, 9 of the patients' tumor specimens were positive for BCL6 protein expression. Eight of 13 monomorphic lesions were BCL6 positive, compared with 1 of 11 evaluable polymorphic lesions (P=0.01). Only 1 of the patients with BCL6 expression responded to reduced immune suppression (P=0.19). Recipients of heart transplants who developed PTLD had reduced overall survival rates compared with recipients of other organ transplants who developed PTLD (P=0.04).
Porter
Christopher C
CC
Department of Pediatrics, Center for Cancer and Blood Disorders, The Children's Hospital and University of Colorado Denver, Aurora, CO, USA.
Liang
Xiayuan
X
Gralla
Jane
J
McGavran
Loris
L
Albano
Edythe A
EA
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004268:DNA-Binding Proteins / Q000032:analysis*; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D007223:Infant; D008232:Lymphoproliferative Disorders / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D016377:Organ Transplantation / Q000009:adverse effects* / Q000401:mortality; D011379:Prognosis; D051560:Proto-Oncogene Proteins c-bcl-6; D015996:Survival Rate
C084103:BCL6 protein, human; D004268:DNA-Binding Proteins; D051560:Proto-Oncogene Proteins c-bcl-6
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