title: Propolis suppresses tumor angiogenesis by inducing apoptosis in tube-forming endothelial cells.
abstract: We have reported that propolis suppresses tumor-induced angiogenesis in vivo and in vitro, but antiangiogenic mechanism of propolis at cellular level remains unclear. In this study, we observed that propolis not only inhibited tube formation but also induced apoptosis of endothelial cells. These results suggest that propolis exerts its antiangiogenic effects at least in part through induction of apoptosis.
authors.affiliation: Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan. ohtat@u-shizuoka-ken.ac.jp
authors.forename: Toshiro
authors.initials: T
authors.lastname: Ohta
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kunimasa
authors.forename: Tomomi
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Miwa
authors.initials: M
authors.lastname: Sakamoto
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kaji
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D017209:Apoptosis / Q000187:drug effects* / Q000235:genetics; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D042783:Endothelial Cells / Q000187:drug effects* / Q000378:metabolism; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D005260:Female; D006801:Humans; D051379:Mice; D008813:Mice, Inbred ICR; D009389:Neovascularization, Pathologic / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D011429:Propolis / Q000494:pharmacology* / Q000627:therapeutic use; D012510:Sarcoma 180 / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D014471:Umbilical Veins / Q000166:cytology / Q000187:drug effects / Q000378:metabolism
chemical_list: D020533:Angiogenesis Inhibitors; D011429:Propolis