The significance of potassium chloride sensitivity test and urinary uronic acid level in the diagnosis of chronic pelvic pain syndrome.
OBJECTIVE
Noninvasive tests are needed for the diagnosis of chronic pelvic pain syndrome. We evaluated the significance of potassium chloride sensitivity test and urinary CTAB-precipitable uronate level in patients with chronic pelvic pain syndrome (CPPS).


METHODS
We included 25 patients with interstitial cystitis (IC), and 30 patients with chronic prostatitis (CP) who applied to our outpatient clinic with the complaints of frequency, dysuria and pain on urination between the years 2003 and 2005. Thirty-five subjects were studied as healthy controls. All patients underwent cystoscopy, cystometry, voiding diary, sodium chloride, and potassium chloride filling tests. Visual analog scale (VAS) was used to determine pain scores. Patients with CP also underwent NaCl and KCl voiding tests. Urinary CTAB-precipitable uronate levels were obtained in all subjects.


RESULTS
KCl test had a good sensitivity for IC. As for the patients with CP, KCl voiding test was useful, but KCl filling test was not. Urinary CTAB-precipitable uronate level was found to be significantly higher in patients with IC and CP than controls, and in patients with IC than in patients with CP.


CONCLUSIONS
The results of our study suggest that KCl voiding test is a good candidate to be used in the diagnostic workup of patients with category III CP, and urinary CTAB-precipitable uronate level measurement may be a noninvasive diagnostic aid for IC and CP.
Alp
Bilal Firat
BF
Department of Urology, Maresal Cakmak Hospital, Erzurum, Turkey.
Akyol
Ilker
I
Adayener
Cuneyt
C
Senkul
Temucin
T
Gultepe
Mustafa
M
Baykal
Kadir
K
Iseri
Cuneyt
C
D000328:Adult; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement / Q000379:methods*; D011189:Potassium Chloride; D011472:Prostatitis / Q000175:diagnosis* / Q000652:urine*; D014574:Uronic Acids / Q000652:urine*
D014574:Uronic Acids; D011189:Potassium Chloride
Eur Urol. 2004 Dec;46(6):681-9
15548433
Urol Clin North Am. 1994 Feb;21(1):21-30
8284842
Urology. 2001 Mar;57(3):428-32; discussion 432-3
11248610
Int Urol Nephrol. 1999;31(4):431-5
10668936
Urology. 1990 Aug;36(2):146-53
2385883
J Urol. 2002 Sep;168(3):1054-7
12187221
Neurourol Urodyn. 2007;26(2):267-70
17078084
J Urol. 2000 Oct;164(4):1381-4
10992419
Clin Chim Acta. 2007 Mar;378(1-2):206-15
17261277
J Urol. 2001 Mar;165(3):842-5
11176483
J Urol. 1998 Jun;159(6):1862-6; discussion 1866-7
9598476
Anal Biochem. 1973 Aug;54(2):484-9
4269305
Tech Urol. 1996 Fall;2(3):171-3
9118427
Ann Clin Biochem. 1975 Sep;12(5):207-11
15637905
J Urol. 2004 Aug;172(2):548-50
15247726
J Urol. 2002 Aug;168(2):556-7
12131308
J Urol. 1993 Apr;149(4):716-8
8455229
Urology. 1995 Apr;45(4):587-90
7716839
J Urol. 2005 Jul;174(1):344-9
15947687
J Urol. 1993 Jan;149(1):31-5
8417212
Urology. 1999 Aug;54(2):229-33
10443716
J Urol. 1999 Sep;162(3 Pt 1):699-701
10458346
J Urol. 2000 May;163(5):1577-83
10751891
Int J Urol. 2007 Aug;14(8):738-42
17681066