title: Slow dynamic lymphoscintigraphy is not a reliable predictor of sentinel-node negativity in cutaneous melanoma.
abstract: We reviewed data from 160 consecutive patients (89 M/71 F; 53.5 [range, 9-88] years) who had under-gone lymphoscintigraphy and sentinel lymph node biopsy (SNB) in our hospital for histologically proven cutaneous malignant melanoma (CMM) (located on the upper limb: 33; lower limb: 57; trunk: 44; and head and neck: 26 patients), with a Breslow index > 1 mm and without clinical or radiologic evidence of metastatic spread. Colloidal (99m)Tc-rhenium sulfide (36-76 MBq) was injected intradermally in the four quadrants around the tumorectomy scar, followed by dynamic acquisition and static imaging. SN(s) were identified in 157 patients (overall identification rate, 98%). Fast (< 20 minutes), intermediate (20-30 minutes), or slow (> 30 minutes) lymphatic drainage was observed, respectively, in 122 (78%), 24 (15%), or 11 (7%) cases. Overall malignancy rate was 15%, respectively found in 19 (16%), 2 (8%), and 2 (18 %) patients with fast, intermediate, or slow drainage. No statistical difference between SN-positivity rates of patients with fast (19/122 = 16%) versus intermediate or slow drainage (4/35 = 11.4%) was observed (p = 0.69). Therefore, lymphoscintigraphic SN appearance time in CMM patients is unable both to predict SN metastasis and spare them from undergoing SN excision.
authors.affiliation: Nuclear Medicine Department, Saint-Louis Hospital AP-HP, Paris 7 University, Paris, France.
authors.forename: Marie-Elisabeth
authors.initials: ME
authors.lastname: Toubert
authors.forename: Pierre-Alexandre
authors.initials: PA
authors.lastname: Just
authors.forename: Georges
authors.initials: G
authors.lastname: Baillet
authors.forename: Delphine
authors.initials: D
authors.lastname: Kerob
authors.forename: Elif
authors.initials: E
authors.lastname: Hindié
authors.forename: Olivier
authors.initials: O
authors.lastname: Verola
authors.forename: Marc
authors.initials: M
authors.lastname: Revol
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Servant
authors.forename: Nicole
authors.initials: N
authors.lastname: Basset-Seguin
authors.forename: Celeste
authors.initials: C
authors.lastname: Lebbé
authors.forename: Elena
authors.initials: E
authors.lastname: Banti
authors.forename: Domenico
authors.initials: D
authors.lastname: Rubello
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Moretti
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis / Q000175:diagnosis*; D008220:Lymphography / Q000379:methods*; D008297:Male; D008545:Melanoma / Q000473:pathology*; D008875:Middle Aged; D011877:Radionuclide Imaging / Q000379:methods*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012211:Rhenium; D012680:Sensitivity and Specificity; D021701:Sentinel Lymph Node Biopsy; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*; D013671:Technetium Tc 99m Sulfur Colloid
chemical_list: D019275:Radiopharmaceuticals; C030406:technetium Tc rhenium-sulfur colloid; D013671:Technetium Tc 99m Sulfur Colloid; D012211:Rhenium