Parathyroid hormone and the cardiovascular system.
The classical actions of parathyroid hormone (PTH) are well recognized, but its effects on other target tissues, such as the cardiovascular system, are less appreciated. Several studies have evaluated the effects of PTH in patients with primary hyperparathyroidism in order to understand potential cardiovascular effects in terms of hypertension, cardiovascular mortality, left ventricular function, and endothelial function. We review these studies and evaluate the cellular mechanisms that may affect these outcomes.
Fitzpatrick
Lorraine A
LA
Research and Development, Musculoskeletal Diseases, GlaxoSmithKline, 2301 Renaissance Boulevard, RN0420, King of Prussia, PA 19406, USA. lorraine.a.fitzpatrick@gsk.com
Bilezikian
John P
JP
Silverberg
Shonni J
SJ
D000818:Animals; D002318:Cardiovascular Diseases / Q000503:physiopathology; D002319:Cardiovascular System / Q000503:physiopathology*; D004195:Disease Models, Animal; D006801:Humans; D006961:Hyperparathyroidism / Q000503:physiopathology; D006973:Hypertension / Q000503:physiopathology; D010281:Parathyroid Hormone / Q000502:physiology*; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology
D010281:Parathyroid Hormone
J Hypertens. 1997 Nov;15(11):1271-6
9383176
Endocrinology. 1995 Jun;136(6):2497-504
7750471
Hypertension. 1999 Sep;34(3):484-90
10489398
Hypertension. 2000 May;35(5):1154-9
10818080
Surgery. 2001 Dec;130(6):986-90
11742327
J Clin Endocrinol Metab. 2005 Jun;90(6):3326-30
15769995
J Clin Invest. 1981 Apr;67(4):1215-27
6259214
Eur J Cardiovasc Prev Rehabil. 2004 Feb;11(1):69-74
15167209
J Cell Biochem. 2005 Jun 1;95(3):437-44
15786490
Am J Physiol. 1993 Jun;264(6 Pt 2):H1998-2006
8322930
World J Surg. 2002 Jun;26(6):657-60
12053214
J Clin Endocrinol Metab. 2000 Oct;85(10):3515-9
11061493
Br J Surg. 2000 Nov;87(11):1529-33
11091241
Cardiovasc Res. 1998 Jan;37(1):34-41
9539855
Calcif Tissue Int. 1996 Jan;58(1):70-1
8825242
Endocrinology. 1989 Aug;125(2):834-41
2752979
Arterioscler Thromb Vasc Biol. 1997 Jun;17(6):1135-42
9194765
Circulation. 2005 Apr 5;111(13):1666-71
15795327
Am J Med. 1998 Feb;104(2):115-22
9528728
J Clin Epidemiol. 1997 Aug;50(8):967-73
9291883
Miner Electrolyte Metab. 1995;21(1-3):77-81
7565468
Surgery. 1987 Jul;102(1):1-7
3589970
Clin Endocrinol (Oxf). 1999 Mar;50(3):321-8
10435057
Eur J Endocrinol. 2002 Oct;147(4):453-9
12370105
Nephrol Dial Transplant. 2007 Oct;22(10):2831-7
17545677
Metabolism. 2007 Jan;56(1):30-6
17161223
Nephrol Dial Transplant. 1997 May;12(5):933-8
9175045
World J Surg. 1992 Jul-Aug;16(4):732-5; discussion 736
1413842
Int J Cardiovasc Imaging. 2007 Jun;23(3):323-8
17036158
J Clin Endocrinol Metab. 2000 May;85(5):1815-21
10843158
South Med J. 1989 Sep;82(9):1116-8
2772681
Surgery. 2002 Dec;132(6):1126-32; discussion 1132
12490865
World J Surg. 2005 Jul;29(7):914-6
15951936
Endocrinology. 1992 Apr;130(4):2045-51
1312438
J Clin Hypertens. 1986 Dec;2(4):360-70
3543230
Clin Endocrinol (Oxf). 2005 Nov;63(5):493-8
16268799
J Intern Med. 2007 Jun;261(6):558-65
17547711
J Clin Endocrinol Metab. 1997 Jan;82(1):106-12
8989242
Surgery. 2005 Jun;137(6):632-8
15933631
World J Surg. 2004 Jan;28(1):108-11
14648050
Atherosclerosis. 2007 Oct;194(2):426-32
17030035
World J Surg. 1991 May-Jun;15(3):399-405; discussion 406-7
1853620
J Clin Endocrinol Metab. 1996 Jun;81(6):2149-53
8964843
Kidney Blood Press Res. 2003;26(1):27-33
12697974
Cardiovasc Res. 2000 Sep;47(4):813-8
10974230
Surgery. 2000 Dec;128(6):895-902
11114621
Circulation. 1997 Nov 18;96(10):3704-9
9396474
Surgery. 2003 Dec;134(6):1013-9; discussion 1019
14668735
Can J Physiol Pharmacol. 1983 Oct;61(10):1162-7
6315205
J Pharmacol Exp Ther. 1991 Jan;256(1):110-8
1988652
Horm Metab Res. 2006 Feb;38(2):125-9
16523414
Int J Cardiol. 1992 Jun;35(3):303-10
1612792
Endocrinology. 1995 Jul;136(7):3024-30
7789328