Eating the enemy within: autophagy in infectious diseases.
Autophagy is emerging as a central component of antimicrobial host defense against diverse viral, bacterial, and parasitic infections. In addition to pathogen degradation, autophagy has other functions during infection such as innate and adaptive immune activation. As an important host defense pathway, microbes have also evolved mechanisms to evade, subvert, or exploit autophagy. Additionally, some fungal pathogens harness autophagy within their own cells to promote pathogenesis. This review will highlight our current understanding of autophagy in infection, focusing on the most recent advances in the field, and will discuss the potential implications of these studies in the design of anti-infective therapeutics.
Orvedahl
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A
Howard Hughes Medical Institute and Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.
Levine
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D000818:Animals; D001343:Autophagy / Q000276:immunology*; D001424:Bacterial Infections / Q000276:immunology* / Q000628:therapy; D005075:Biological Evolution; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D009181:Mycoses / Q000276:immunology* / Q000628:therapy; D010272:Parasitic Diseases / Q000276:immunology* / Q000628:therapy; D014777:Virus Diseases / Q000276:immunology* / Q000628:therapy
Autophagy. 2007 Nov-Dec;3(6):581-5
17700057
J Virol. 2008 Mar;82(5):2241-9
18077704
Cell Microbiol. 2005 Jul;7(7):981-93
15953030
J Cell Biol. 2003 Dec 8;163(5):1123-31
14662750
PLoS Biol. 2005 May;3(5):e156
15884975
Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):6031-6
17389386
Science. 2006 Apr 28;312(5773):580-3
16645096
Cell Microbiol. 2003 Jul;5(7):455-68
12814436
J Immunol. 2006 Oct 15;177(8):5163-8
17015701
J Virol. 1998 Nov;72(11):8586-96
9765397
Autophagy. 2007 Nov-Dec;3(6):620-2
17786022
Autophagy. 2008 Jan;4(1):20-7
17932459
Autophagy. 2007 May-Jun;3(3):245-8
17224624
Cell Res. 2006 Nov;16(11):895-901
17088896
Mol Cell. 2008 Jun 20;30(6):678-88
18570871
Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14578-83
16983090
J Clin Invest. 2006 Sep;116(9):2366-77
16955139
Cell. 2008 Jan 11;132(1):27-42
18191218
J Exp Med. 2007 Jan 22;204(1):25-31
17190837
Autophagy. 2006 Apr-Jun;2(2):91-5
16874104
Science. 2007 Mar 9;315(5817):1398-401
17272685
Cell Microbiol. 2008 Mar;10(3):593-605
17979984
PLoS Pathog. 2008 Feb 8;4(2):e25
18248095
J Biol Chem. 2006 Apr 21;281(16):11384-96
16497676
Nat Genet. 2007 Feb;39(2):207-11
17200669
Science. 2006 Sep 8;313(5792):1438-41
16888103
Eukaryot Cell. 2007 Dec;6(12):2437-47
17921348
Immunity. 2008 Jun;28(6):799-809
18513998
Autophagy. 2008 Jan;4(1):46-53
18340111
Microbiology (Reading). 2007 Jan;153(Pt 1):51-8
17185534
PLoS Pathog. 2007 Aug 10;3(8):e111
17696608
Nat Rev Microbiol. 2004 Apr;2(4):301-14
15031729
Science. 2008 Feb 15;319(5865):921-6
18187620
J Biol Chem. 2006 Apr 21;281(16):11374-83
16495224
Autophagy. 2007 Sep-Oct;3(5):442-51
17568179
Autophagy. 2007 Mar-Apr;3(2):117-25
17204850
Nature. 2007 Dec 20;450(7173):1253-7
18097414
Nature. 2008 Jan 17;451(7176):350-4
18202661
Science. 2005 Feb 4;307(5710):727-31
15576571
Autophagy. 2007 Sep-Oct;3(5):472-3
17495517
Autophagy. 2008 Apr;4(3):280-5
18059171
Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12497-502
18713860
Nat Immunol. 2008 Aug;9(8):908-16
18604211
Cell. 2004 Dec 17;119(6):753-66
15607973
Immunity. 2007 Jan;26(1):79-92
17182262
Autophagy. 2006 Jan-Mar;2(1):24-9
16874088
Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1829-34
17267617
Mol Microbiol. 2003 Jan;47(2):321-33
12519185
Autophagy. 2008 Aug;4(6):744-53
18483470
Nat Genet. 2007 May;39(5):596-604
17435756
Cell. 2005 Jan 28;120(2):159-62
15680321
J Clin Invest. 2006 Aug;116(8):2161-72
16886061
Cell. 2005 Sep 23;122(6):927-39
16179260
Eur J Immunol. 2003 May;33(5):1250-9
12731050
Cell Microbiol. 2007 Apr;9(4):1073-85
17166233
J Virol. 2007 Oct;81(19):10815-7
17670838
Eukaryot Cell. 2007 Jun;6(6):997-1005
17416896
Cell. 2006 Feb 24;124(4):783-801
16497588
Immunity. 2007 Sep;27(3):505-17
17892853
Virology. 2008 May 10;374(2):240-8
18353420
Cell Host Microbe. 2007 Mar 15;1(1):23-35
18005679
Development. 2008 Aug;135(14):2347-60
18567846
Nat Cell Biol. 2006 Jul;8(7):688-99
16799551
AIDS. 2008 Mar 30;22(6):695-9
18356598
EMBO J. 2008 Apr 9;27(7):1110-21
18337753
Science. 2005 Jan 28;307(5709):593-6
15591165
Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):190-5
11756670
Folia Microbiol (Praha). 2007;52(6):631-6
18450226
Virology. 2006 Jun 5;349(2):254-63
16643977
Nature. 2007 Jun 7;447(7145):661-78
17554300
Mol Microbiol. 2006 Aug;61(3):655-74
16803590
Nat Genet. 2007 Jul;39(7):830-2
17554261
Immunity. 2007 Jul;27(1):135-44
17658277
Immunity. 2007 Jul;27(1):11-21
17663981
PLoS Pathog. 2006 Oct;2(10):e102
17040126
Cell Cycle. 2007 Aug 1;6(15):1837-49
17671424
Nat Cell Biol. 2007 Oct;9(10):1102-9
17909521
Eukaryot Cell. 2005 Nov;4(11):1765-74
16278443
Nat Rev Drug Discov. 2007 Apr;6(4):304-12
17396135
J Exp Med. 2006 Sep 4;203(9):2063-71
16940170
Cell Death Differ. 2007 Feb;14(2):230-9
16794605
J Biol Chem. 2008 Feb 8;283(6):3454-3464
18039653
J Virol. 2008 Sep;82(18):9143-53
18596087
Science. 2004 Nov 5;306(5698):1037-40
15528445
Cell Res. 2007 Jun;17(6):520-30
17563756
Nat Rev Immunol. 2007 Oct;7(10):767-77
17767194
J Mol Med (Berl). 2007 Aug;85(8):811-23
17340132
Proc Natl Acad Sci U S A. 2005 May 31;102(22):7922-7
15894616
Autophagy. 2008 Apr;4(3):309-14
18188005
Infect Immun. 2008 Jan;76(1):278-88
17923513
J Virol. 2007 Nov;81(22):12543-53
17804493
Cell. 2005 May 20;121(4):567-577
15907470
Nature. 2007 Apr 12;446(7137):745-7
17429391
Autophagy. 2008 Apr;4(3):361-3
18212533
J Biochem. 2006 Aug;140(2):161-6
16954534
J Biol Chem. 2007 Jan 26;282(4):2695-706
17135247
Cell. 2007 Mar 9;128(5):931-46
17350577
Autophagy. 2007 Sep-Oct;3(5):527-36
17617735
J Clin Invest. 2008 Mar;118(3):1186-97
18259613
J Biol Chem. 2006 Oct 13;281(41):30373-82
16857678