title: Hemophagocytic lymphohistiocytosis associated with Epstein Barr virus and Leishmania donovani coinfection in a child from Cyprus.
abstract: We present a case of a 9-month-old girl from Cyprus with hemophagocytic lymphohistiocytosis associated with Epstein Barr virus and Leishmania donovani coinfection. Treatment with liposomal amphotericin B resulted in a dramatic resolution of clinical and laboratory abnormalities. To our knowledge, this is the first reported case of a coinfection-associated hemophagocytic lymphohistiocytosis and the first clinical report of visceral leishmaniasis infection in Europe by L. donovani.
authors.affiliation: Department of Pediatrics, Infectious Diseases and Immunology Unit, Archbishop Makarios Hospital, Nicosia, Cyprus. mkoliou@spidernet.com.cy
authors.forename: Maria G
authors.initials: MG
authors.lastname: Koliou
authors.forename: Elpidoforos S
authors.initials: ES
authors.lastname: Soteriades
authors.forename: Moshe
authors.initials: M
authors.lastname: Ephros
authors.forename: Apostolos
authors.initials: A
authors.lastname: Mazeris
authors.forename: Maria
authors.initials: M
authors.lastname: Antoniou
authors.forename: Avraam
authors.initials: A
authors.lastname: Elia
authors.forename: Vas
authors.initials: V
authors.lastname: Novelli
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D003535:Cyprus; D020031:Epstein-Barr Virus Infections / Q000150:complications; D005260:Female; D004854:Herpesvirus 4, Human; D006801:Humans; D007223:Infant; D007893:Leishmania donovani; D007898:Leishmaniasis, Visceral / Q000150:complications; D051359:Lymphohistiocytosis, Hemophagocytic / Q000469:parasitology* / Q000821:virology*
chemical_list: D000666:Amphotericin B