Synthesis of the peptide nucleic acid (PNA) incorporating 2-amino-6-vinylpurine derivative and evaluation of the reactivity.
Previously, we established a new strategy of synchronous cross linking reaction activated by hybridization to target genes. In this strategy, the highly reactive cross-linking agent, 2-amino-6-vinylpurine nucleoside analog, is generated from its stable precursors by a hybridization-promoted activation process with selectivity to cytosine. In this paper, we wish to report the synthesis of the peptide nucleic acids (PNAs) incorporating 2-amino-6-vinylpurine derivatives and the evaluation of their reactivity to target DNA.
Imoto
Shuhei
S
Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai-Shi, Miyagi, Japan.
Shimotazawa
Azusa
A
Hirohama
Tomoya
T
Goto
Makoto
M
Nagatsugi
Fumi
F
D003432:Cross-Linking Reagents / Q000737:chemistry*; D003596:Cytosine / Q000737:chemistry; D004247:DNA / Q000737:chemistry; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D011687:Purines / Q000737:chemistry*; D014753:Vinyl Compounds / Q000737:chemistry*
C432203:2-amino-6-vinylpurine; D003432:Cross-Linking Reagents; D020135:Peptide Nucleic Acids; D011687:Purines; D014753:Vinyl Compounds; D003596:Cytosine; D004247:DNA