Sensing necrosis with Mincle.
The mechanisms that lead to inflammation after necrotic cell death are poorly understood. New data show that the C-type lectin Mincle is involved in this process.
Brown
Gordon D
GD
Institute of Infectious Disease and Molecular Medicine, Clinical Laboratory Sciences, Division of Immunology, University of Cape Town, Observatory 7925, Cape Town, South Africa. gordon.brown@mweb.co.za
D000818:Animals; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D018836:Inflammation Mediators / Q000276:immunology*; D037181:Lectins, C-Type / Q000276:immunology*; D008565:Membrane Proteins / Q000276:immunology; D018448:Models, Immunological; D009336:Necrosis / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*
D018836:Inflammation Mediators; D037181:Lectins, C-Type; D008565:Membrane Proteins