title: New conformationally restricted DNA mimics.
abstract: Two novel bicyclic nucleotide monomers have been developed for use as DNA mimics. Melting temperature studies showed that these modifications decrease binding affinity towards complementary DNA and RNA.
authors.affiliation: Nucleic Acid Center, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark. tho@ifk.sdu.dk
authors.forename: Torben
authors.initials: T
authors.lastname: Højland
authors.forename: B Ravindra
authors.initials: BR
authors.lastname: Babu
authors.forename: Jesper
authors.initials: J
authors.lastname: Wengel
mesh_terms: D004247:DNA / Q000737:chemistry*; D018716:Molecular Mimicry; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D013696:Temperature
chemical_list: D009841:Oligonucleotides; C477371:locked nucleic acid; D004247:DNA