title: Etiology and short-term prognosis of severe mitral regurgitation.
abstract: OBJECTIVE
  To describe the etiology and to document the course of severe mitral regurgitation (MR).
  
  
  METHODS
  Prospective registry of 272 patients diagnosed with chronic severe MR in an echocardiographic study.
  
  
  RESULTS
  Mean age was 70.2 +/- 13.8 years and 143 patients were women (53%). The most frequent causes of regurgitation were rheumatic disease (72 patients; 26%), ischemic etiology (58; 21%), valve prolapse (57; 21%), and dilated cardiomyopathy (49; 18%). A total of 43 patients (16%) died during follow-up (mean 0.9 +/- 0.3 years, total 2,785 patient-months): 30 from cardiac causes, 9 from non-cardiac causes, and 4 from unknown causes. Actuarial transplant-free survival was 87% at 6 months, and 81% at 1 year. Renal disease, previous stroke, ischemic etiology, and poor left ventricular ejection fraction were independent predictors of mortality.
  
  
  CONCLUSIONS
  Rheumatic disease is still the main cause of severe MR in Spain. Patients with severe MR have advanced age and present poor short-term prognosis.
authors.affiliation: Cardiology Department, Hospital Universitario Gregorio Marañón, Dr. Esquerdo, 46, 28007 Madrid, Spain. mmselles@secardiologia.es
authors.forename: Manuel
authors.initials: M
authors.lastname: Martínez-Sellés
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: García-Fernández
authors.forename: Edith
authors.initials: E
authors.lastname: Larios
authors.forename: Mar
authors.initials: M
authors.lastname: Moreno
authors.forename: Angel
authors.initials: A
authors.lastname: Pinto
authors.forename: José Antonio
authors.initials: JA
authors.lastname: García-Robles
authors.forename: Esther
authors.initials: E
authors.lastname: Pérez-David
authors.forename: Francisco
authors.initials: F
authors.lastname: Fernández-Avilés
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D008944:Mitral Valve Insufficiency / Q000209:etiology* / Q000503:physiopathology*; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012042:Registries; D013030:Spain; D015996:Survival Rate
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