Stem cells for kidney repair: useful tool for acute renal failure?
Several cell types isolated from adult tissues have been reported to differentiate into mature kidney cells that may participate in renal repair after systemic administration. Chen et al. report that local mesenchymal stem cells derived from adult mouse kidneys are another source of cells with similar properties. Although these cells have the potential to differentiate into endothelial-lineage cell types, their therapeutic benefit to the ischemic kidney is mainly via the production of renoprotective factors.
Yokoo
Takashi
T
Project Laboratory for Kidney Regeneration, Division of Nephrology and Hypertension, Department of Internal Medicine, Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, Japan. tyokoo@jikei.ac.jp
Kawamura
Tetsuya
T
Kobayashi
Eiji
E
D058186:Acute Kidney Injury / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007684:Kidney Tubules / Q000473:pathology; D012038:Regeneration; D044968:Regenerative Medicine / Q000379:methods; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000166:cytology / Q000502:physiology