title: Counteracting clotting in sepsis.
abstract: The complexity of factors that regulate bleeding and coagulation has long confounded researchers. Andrew Wei and Shaun Jackson help clear the air by examining clinical findings pointing to a mechanistic basis for a common bleeding disorder, immune thrombocytopenic purpura. Mark Kahn tackles two research studies that could lead to improved therapies for a coagulation syndrome that hits people with severe sepsis.
authors.affiliation: University of Pennsylvania, 925 BRB II/III, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA. markkahn@med.upenn.edu
authors.forename: Mark L
authors.initials: ML
authors.lastname: Kahn
mesh_terms: D001777:Blood Coagulation / Q000502:physiology*; D006801:Humans; D011486:Protein C / Q000378:metabolism; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood*; D044463:Receptor, PAR-1 / Q000378:metabolism*; D018805:Sepsis / Q000097:blood / Q000628:therapy*
chemical_list: D011486:Protein C; D044463:Receptor, PAR-1