Relationship of elevated osteoprotegerin with insulin resistance, CRP, and TNF-alpha levels in men with type 2 diabetes.
OBJECTIVE
Our objective of this study is to investigate the relationship between plasma osteoprotegerin (OPG) levels in type 2 diabetes and its relationship with the insulin resistance, HbA(1c), CRP, and TNF-alpha levels.


METHODS
In a cross-sectional study, levels of OPG were determined in 50 subjects with type 2 diabetes and 59 control subjects without diabetes. The OPG levels between the groups were compared and their correlation with insulin resistance, glycemia and inflammatory markers CRP and TNF-alpha was determined.


RESULTS
OPG levels were elevated in subjects with diabetes (6.8+/-0.27 pmol/l), compared to control subjects (5.7+/-0.26 pmol/l). OPG levels significantly correlate with insulin, insulin resistance, CRP, and TNF-alpha.


CONCLUSIONS
OPG levels are significantly correlated with insulin resistance and may reflect the proinflammatory state in type 2 diabetes.
Yaturu
Subhashini
S
Department of Endocrinology, Overton Brooks VA Medical Center/LSUHSC, 510 East Stoner Avenue, 111E, Shreveport, LA 71101-4295, USA. Subhashini.Yaturu@va.gov
Rains
Justin
J
Jain
Sushil K
SK
D002097:C-Reactive Protein / Q000378:metabolism*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000503:physiopathology*; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D053244:Osteoprotegerin / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D002097:C-Reactive Protein; D006442:Glycated Hemoglobin; D053244:Osteoprotegerin; D014409:Tumor Necrosis Factor-alpha; C506030:TNFRSF11B protein, human; C517652:hemoglobin A1c protein, human