title: [Determination of ADAMTS13 antigen and activity levels in patients with acute myocardial infarction and acute ischemic stroke].
abstract: OBJECTIVE
  To investigate the ADAMTS13 antigen levels and activity in patients with acute myocardial infarction (AMI) and acute ischemic stroke (AIS), and explore its significance in these diseases.
  
  
  METHODS
  ADAMTS13 activity levels were detected by a new developed Frests-vWF73 kit, ADAMTS13 antigen levels by ELISA kit, and vWF multimers by electrophoresis.
  
  
  RESULTS
  ADAMTS13 antigen in normal control, AMI and AIS was (878 +/- 198), (618 +/- 188) and (702 +/- 155) U/L, and ADAMTS13 activity was (81.7 +/- 13.9)%, (59.2 +/- 22.1 )% and (65.4 +/- 15.8)%, respectively, being significantly decreased in AMI and AIS patients.
  
  
  CONCLUSIONS
  ADMATS13 might involve in arterial infarction diseases.
authors.affiliation: iangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
authors.forename: Ning-Zheng
authors.initials: NZ
authors.lastname: Dong
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.forename: Shun-Dong
authors.initials: SD
authors.lastname: Ji
authors.forename: Chang-Geng
authors.initials: CG
authors.lastname: Ruan
mesh_terms: D051722:ADAM Proteins / Q000097:blood*; D000071120:ADAMTS13 Protein; D000368:Aged; D000369:Aged, 80 and over; D020520:Brain Infarction / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D014841:von Willebrand Factor / Q000378:metabolism
chemical_list: D014841:von Willebrand Factor; D051722:ADAM Proteins; D000071120:ADAMTS13 Protein; C099604:ADAMTS13 protein, human