title: Normalization of 14-3-3 in CJD.
abstract: We report on a 47-year-old woman with autopsy proven Creutzfeldt-Jakob disease (CJD), who had a positive initial 14-3-3 test but a subsequent negative test under pharmacologic suppression of the periodic epileptiform discharges on EEG. Multiple factors associated with a subsequent 14-3-3 test becoming negative are known. However none of these circumstances were applicable to our patient. This case history suggests sedative therapy in CJD may induce false negative 14-3-3 testing. This appears to be a relevant finding, since the differential diagnosis between non-convulsive status epilepticus and CJD is not always evident in the initial stage of the disease and some patients with CJD present with seizures.
authors.affiliation: Department of Neurology, University of Leuven, Belgium. maarten.schrooten@uzleuven.be
authors.forename: Maarten
authors.initials: M
authors.lastname: Schrooten
authors.forename: Wouter
authors.initials: W
authors.lastname: De Vooght
authors.forename: Sarah
authors.initials: S
authors.lastname: Weckhuysen
authors.forename: Wim
authors.initials: W
authors.lastname: Van Paesschen
authors.forename: Philip
authors.initials: P
authors.lastname: Van Damme
mesh_terms: D048948:14-3-3 Proteins / Q000134:cerebrospinal fluid*; D000927:Anticonvulsants / Q000627:therapeutic use; D001883:Borderline Personality Disorder / Q000150:complications; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D016292:Procedural Sedation / Q000009:adverse effects*; D007562:Creutzfeldt-Jakob Syndrome / Q000134:cerebrospinal fluid* / Q000150:complications / Q000175:diagnosis*; D004569:Electroencephalography; D005189:False Positive Reactions; D001068:Feeding and Eating Disorders / Q000150:complications; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D015151:Immunoblotting; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D013001:Somatoform Disorders / Q000150:complications; D013226:Status Epilepticus / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology
chemical_list: D048948:14-3-3 Proteins; D000927:Anticonvulsants; C482982:YWHAB protein, human