title: Suppression of pleiotropic effects of functional cryptochrome genes by Terminal Flower 1.
abstract: TERMINAL FLOWER 1 (TFL1) encodes a protein with similarity to animal phosphatidylethanolamine-binding proteins and is required for normal trafficking to the protein storage vacuole. In Arabidopsis thaliana the tfl1 mutation produces severe developmental abnormalities. Here we show that most aspects of the tfl1 phenotype are lost in the cry1 cry2 double-mutant background lacking cryptochromes 1 and 2. The inhibition of hypocotyl growth by light is reduced in the tfl1 mutant but this effect is absent in the cry1 or cry2 mutant background. Although the promotion of flowering under long rather than short days is a key function of cryptochromes, in the tfl1 background, cryptochromes promoted flowering under short days. Thus, normal CRY control of photoperiod-dependent flowering and hypocotyl growth inhibition requires a functional TFL1 gene.
authors.affiliation: IFEVA, Fisiología Vegetal, Facultad de Agronomía, Universidad de Buenos Aires, Buenos Aires, Argentina.
authors.forename: Ana Sabrina
authors.initials: AS
authors.lastname: Buchovsky
authors.forename: Bárbara
authors.initials: B
authors.lastname: Strasser
authors.forename: Pablo D
authors.initials: PD
authors.lastname: Cerdán
authors.forename: Jorge J
authors.initials: JJ
authors.lastname: Casal
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000254:growth & development*; D029681:Arabidopsis Proteins / Q000502:physiology*; D056931:Cryptochromes; D005420:Flavoproteins / Q000502:physiology*; D035264:Flowers / Q000254:growth & development*; D018546:Hypocotyl / Q000254:growth & development*; D009154:Mutation / Q000235:genetics; D010641:Phenotype; D013489:Suppression, Genetic
chemical_list: D029681:Arabidopsis Proteins; C538962:CRY1 protein, Arabidopsis; C103618:CRY2 protein, Arabidopsis; D056931:Cryptochromes; D005420:Flavoproteins; C102864:TFL1 protein, Arabidopsis
references.citation: Science. 1997 Jan 3;275(5296):80-3
references.pmid: 8974397
references.citation: Science. 1998 Feb 27;279(5355):1360-3
references.pmid: 9478898
references.citation: Trends Plant Sci. 2004 Jun;9(6):309-14
references.pmid: 15165563
references.citation: Plant J. 2006 Feb;45(4):630-50
references.pmid: 16441353
references.citation: Mol Gen Genet. 1991 Sep;229(1):57-66
references.pmid: 1896021
references.citation: Plant Cell. 2007 Mar;19(3):767-78
references.pmid: 17369370
references.citation: Q Rev Biol. 2005 Sep;80(3):287-316
references.pmid: 16250465
references.citation: Nature. 2002 Sep 19;419(6904):308-12
references.pmid: 12239570
references.citation: Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18813-8
references.pmid: 18003924
references.citation: Nature. 1996 Nov 7;384(6604):59-62
references.pmid: 8900276
references.citation: Development. 2001 Jun;128(12):2291-9
references.pmid: 11493548
references.citation: Plant Physiol. 2001 Sep;127(1):252-61
references.pmid: 11553753
references.citation: Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18801-6
references.pmid: 18003908
references.citation: Plant J. 1999 Aug;19(3):279-87
references.pmid: 10476075
references.citation: Plant J. 1996 Oct;10(4):755-60
references.pmid: 8893551
references.citation: Nature. 1993 Nov 11;366(6451):162-6
references.pmid: 8232555
references.citation: Science. 2007 Oct 12;318(5848):261-5
references.pmid: 17872410
references.citation: Plant Cell. 1991 Sep;3(9):877-892
references.pmid: 12324621
references.citation: Evolution. 2003 Sep;57(9):1959-72
references.pmid: 14575319
references.citation: Science. 1999 Dec 3;286(5446):1962-5
references.pmid: 10583961
references.citation: Nature. 2003 Jun 19;423(6942):881-5
references.pmid: 12815435
references.citation: Nature. 2001 Apr 26;410(6832):1116-20
references.pmid: 11323677
references.citation: Nature. 1995 Oct 12;377(6549):522-4
references.pmid: 7566148
references.citation: Plant Physiol. 2004 Sep;136(1):2621-32
references.pmid: 15375207
references.citation: Science. 1999 Dec 3;286(5446):1960-2
references.pmid: 10583960
references.citation: Nature. 1995 Oct 12;377(6549):495-500
references.pmid: 7566146
references.citation: Nat Genet. 2001 Dec;29(4):435-40
references.pmid: 11726930
references.citation: Science. 2004 Feb 13;303(5660):1003-6
references.pmid: 14963328
references.citation: Plant Cell. 2002;14 Suppl:S207-25
references.pmid: 12045278
references.citation: Development. 1999 May;126(10):2073-82
references.pmid: 10207133
references.citation: Proc Natl Acad Sci U S A. 2005 May 24;102(21):7748-53
references.pmid: 15894619
references.citation: Development. 1999 Mar;126(6):1109-20
references.pmid: 10021331
references.citation: Plant Cell. 1993 Jun;5(6):639-655
references.pmid: 12271079
references.citation: Development. 1998 May;125(9):1609-15
references.pmid: 9521899