Role of p53 family in birth defects: lessons from zebrafish.
p53 Protein family is an important teratologic suppressor, but in certain conditions it can cause congenital abnormalities. p53 Family performs this dual role in development by integrating information from cell's interior with that from the environment to determine the choice between life and death. Understanding of p53 family developmental functions may lead to new therapeutic approaches for treatment and prevention of birth defects. Zebrafish is becoming the vertebrate system of choice for studying p53 family role in development.
Danilova
Nadia
N
Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, California 90095-1606, USA. ndanilova@ucla.edu
Sakamoto
Kathleen M
KM
Lin
Shuo
S
D000818:Animals; D000013:Congenital Abnormalities / Q000235:genetics*; D004625:Embryo, Nonmammalian / Q000002:abnormalities* / Q000378:metabolism / Q000528:radiation effects; D018507:Gene Expression Regulation, Developmental / Q000235:genetics / Q000528:radiation effects; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*; D015027:Zebrafish / Q000196:embryology / Q000235:genetics / Q000378:metabolism*; D029961:Zebrafish Proteins / Q000235:genetics / Q000378:metabolism*
D020033:Protein Isoforms; D016159:Tumor Suppressor Protein p53; D029961:Zebrafish Proteins