title: [Protein C system in patients with idiopathic pulmonary fibrosis--preliminary report].
abstract: BACKGROUND
  The natural anticoagulant-activated protein C system plays an important role in the pathogenesis of idiopathic pulmonary fibrosis. The purpose of this study was to evaluate the concentration of protein C (PC), protein S (PS), thrombomodulin (TM), selectin E (sSelE), and thrombin-antithrombin complex (TAT) in patients with idiopathic pulmonary fibrosis (IPF).
  
  
  METHODS
  Study group consisted of 11 patients aged 51.5 +/- 8.62 years with idiopathic pulmonary fibrosis and 20 healthy adults as control. Concentration of PC, PS TM, sSelE and TAT in plasma with ELISA method was assessed.
  
  
  RESULTS
  We observed significantly lower plasma concentration of PC (98.24 +/- 16.17% vs. 130.59 +/- 19.03%), PS (71.31 +/- +/- 12.95% vs. 93.47 +/- 18.63%), TM (2.67 +/- 0.40 ng/ml vs. 3.99 +/- 1.16 ng/ml) and significantly higher level of TAT complex (Me = 4.00 mg/ml vs. 2.20 mg/ml) and sSelE (Me = 36.40 ng/ml vs. 22.84 ng/ml) in patients with idiopathic pulmonary fibrosis as compared to controls.
  
  
  CONCLUSIONS
  In presented pilot study we observed decreased activity of protein C system and increased thrombin generation in peripheral blood of patients with idiopathic pulmonary fibrosis.
authors.affiliation: Zakład Zaburzeń Hemostazy, Katedra Patofizjologii Collegium Medicum im, Ludwika Rydygiera w Bydgoszczy, Uniwersytet Mikolaja Kopernika w Toruniu, ul. M. Skladowskiej-Curie 9, Bydgoszcz. kizpatofiz@cm.umk.pl
authors.forename: Anna
authors.initials: A
authors.lastname: Kiziewicz
authors.forename: Ewa
authors.initials: E
authors.lastname: Zekanowska
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Cieśliński
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Góralczyk
mesh_terms: D000328:Adult; D000368:Aged; D000990:Antithrombin III; D016022:Case-Control Studies; D019040:E-Selectin / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000097:blood* / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D010447:Peptide Hydrolases / Q000097:blood; D010865:Pilot Projects; D011486:Protein C / Q000032:analysis*; D017293:Protein S / Q000032:analysis; D012016:Reference Values; D018180:Thrombomodulin / Q000097:blood
chemical_list: D019040:E-Selectin; D011486:Protein C; D017293:Protein S; D018180:Thrombomodulin; C046193:antithrombin III-protease complex; D000990:Antithrombin III; D010447:Peptide Hydrolases