Neural correlates of multisensory cue integration in macaque MSTd.
Human observers combine multiple sensory cues synergistically to achieve greater perceptual sensitivity, but little is known about the underlying neuronal mechanisms. We recorded the activity of neurons in the dorsal medial superior temporal (MSTd) area during a task in which trained monkeys combined visual and vestibular cues near-optimally to discriminate heading. During bimodal stimulation, MSTd neurons combined visual and vestibular inputs linearly with subadditive weights. Neurons with congruent heading preferences for visual and vestibular stimuli showed improvements in sensitivity that parallel behavioral effects. In contrast, neurons with opposite preferences showed diminished sensitivity under cue combination. Responses of congruent cells were more strongly correlated with monkeys' perceptual decisions than were responses of opposite cells, suggesting that the monkey monitored the activity of congruent cells to a greater extent during cue integration. These findings show that perceptual cue integration occurs in nonhuman primates and identify a population of neurons that may form its neural basis.
Gu
Yong
Y
Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, Missouri 63110, USA.
Angelaki
Dora E
DE
Deangelis
Gregory C
GC
D000200:Action Potentials / Q000502:physiology; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal; D003463:Cues; D007839:Functional Laterality; D019416:Head Movements / Q000502:physiology; D007699:Kinesthesis; D008253:Macaca mulatta; D008959:Models, Neurological; D009039:Motion Perception / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D009949:Orientation / Q000502:physiology*; D010775:Photic Stimulation / Q000379:methods; D011336:Probability; D011594:Psychometrics / Q000379:methods; D011601:Psychophysics; D011930:Reaction Time / Q000502:physiology; D017603:Signal Detection, Psychological / Q000502:physiology*; D013702:Temporal Lobe / Q000166:cytology*; D014796:Visual Perception / Q000502:physiology
J Neurosci. 2006 Oct 25;26(43):11138-47
17065454
Trends Cogn Sci. 2006 Jun;10(6):278-85
16713325
J Neurophysiol. 1988 Aug;60(2):580-603
3171643
J Neurosci. 2007 Sep 5;27(36):9742-56
17804635
J Neurophysiol. 2003 Apr;89(4):1994-2013
12686576
Vision Res. 1999 Oct;39(21):3621-9
10746132
Trends Neurosci. 2004 Dec;27(12):712-9
15541511
J Neurosci. 2007 Feb 21;27(8):1922-32
17314288
J Comp Neurol. 1981 Jul 1;199(3):293-326
7263951
Percept Psychophys. 2003 Nov;65(8):1188-96
14710954
Cereb Cortex. 2004 Apr;14(4):452-65
15028649
Annu Rev Neurosci. 1998;21:227-77
9530497
J Neurosci. 2001 Jul 1;21(13):4809-21
11425908
Philos Trans R Soc Lond B Biol Sci. 2002 Aug 29;357(1424):1053-62
12217173
J Neurophysiol. 1988 Aug;60(2):621-44
3171645
Cereb Cortex. 1991 Jan-Feb;1(1):1-47
1822724
J Neurophysiol. 1993 Jan;69(1):128-42
8433128
J Neurosci. 1994 Jul;14(7):4109-24
8027765
Vision Res. 2003 Nov;43(24):2539-58
13129541
Philos Trans R Soc Lond B Biol Sci. 2004 Jun 29;359(1446):929-41
15306408
J Neurophysiol. 1989 Sep;62(3):642-56
2769352
Nat Neurosci. 2007 Dec;10(12):1608-14
17965712
Nat Neurosci. 2005 Jan;8(1):99-106
15608633
J Neurosci. 2005 Jul 13;25(28):6499-508
16014711
Curr Biol. 2004 Feb 3;14(3):257-62
14761661
Percept Psychophys. 2001 Nov;63(8):1293-313
11800458
J Neurosci. 1986 Jan;6(1):134-44
3944614
J Vis. 2004 Dec 01;4(12):967-92
15669906
Vis Neurosci. 1996 Jan-Feb;13(1):87-100
8730992
Nat Neurosci. 2007 Aug;10(8):1038-47
17618278
Neuron. 2004 Apr 22;42(2):297-310
15091344
Nat Neurosci. 2006 Nov;9(11):1432-8
17057707
J Neurosci. 2006 Sep 13;26(37):9567-78
16971541
J Neurosci. 2006 Jan 4;26(1):73-85
16399674
J Neurosci. 1992 Dec;12(12):4745-65
1464765
Ann N Y Acad Sci. 1999 May 28;871:272-81
10372078
J Neurophysiol. 1998 Oct;80(4):1816-27
9772241
J Neurophysiol. 1999 Mar;81(3):1355-64
10085361
J Neurophysiol. 1991 Jun;65(6):1329-45
1875243
Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2167-72
14766982
J Comp Neurol. 1986 Jun 8;248(2):164-89
3722457
J Neurosci. 1995 Jul;15(7 Pt 2):5192-208
7623145
J Neurosci. 1996 Feb 15;16(4):1486-510
8778300
Nature. 2002 Jan 24;415(6870):429-33
11807554