[Significance of the glutaminergic system for obsessive-compulsive disorder].
Obsessive-compulsive disorder (OCD) is a frequent disorder and glutamate seems to be an important transmitter. The effect of glutamate depends on the level as well as the effect mediated through glutamate receptors. The level is altered in brain areas that are involved in OCD. Genes encoding receptors, enzymes involved in the metabolism and transport proteins are located in regions that are related to OCD. Pharmacogenetic studies examining the genetic variations in the glutaminate system are lacking. The aim was to examine the current knowledge on the glutaminate system in the development and maintenance of OCD.
Nissen
Judith Becker
JB
Børne- og Ungdomspsykiatrisk Regionscenter, Arhus Universitetshospital, DK-8240 Risskov. jbbn@dadlnet.dk
Thomsen
Per Hove
PH
D001921:Brain / Q000378:metabolism; D018698:Glutamic Acid / Q000134:cerebrospinal fluid / Q000378:metabolism; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D010597:Pharmacogenetics; D017470:Receptors, Glutamate / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*
D017470:Receptors, Glutamate; D018698:Glutamic Acid