Synthesis of collagen-like sequential polypeptides containing O-phospho-L-hydroxyproline and preparation of electrospun composite fibers for possible dental application.
A synthetic route is described for collagen-like polypeptides constructed from O-phospho-L-hydroxyproline [Hyp(PO(3)H(2))] residues. Using the synthetic polypeptides and a natural protein, gelatin, fine fibers and their network structures (ESNWs) were prepared via electrospinning. The composite ESNWs can induce the mineralization of calcium phosphate. The phosphoryl groups of the Hyp(PO(3)H(2)) residues affect both the crystalline phase and amount of the calcium phosphate, depending on the chemical structure in the repeating sequence. The composite ESNWs can be developed as a biocompatible replacement of the extracellular matrix of hard tissues, and thus can be applied as dental materials for restoration of dental cavities or as a sealant for pits and fissures.
Ohkawa
Kousaku
K
Institute of High Polymer Research, Faculty of Textile Science and Technology, Shinshu University, Tokida 3-15-1, Ueda 386-8567, Nagano Prefecture, Japan. kohkawa@giptc.shinshu-u.ac.jp
Hayashi
Shinya
S
Kameyama
Naoto
N
Yamamoto
Hiroyuki
H
Yamaguchi
Mina
M
Kimoto
Shigenari
S
Kurata
Shigeaki
S
Shinji
Hisaaki
H
D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D002130:Calcium Phosphates / Q000737:chemistry; D003094:Collagen / Q000737:chemistry*; D003460:Crystallization; D003764:Dental Materials / Q000138:chemical synthesis / Q000737:chemistry; D055664:Electrochemical Techniques; D005780:Gelatin / Q000737:chemistry; D006909:Hydroxyproline / Q000737:chemistry*; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry; D013499:Surface Properties
D001672:Biocompatible Materials; D002130:Calcium Phosphates; D003764:Dental Materials; D010455:Peptides; D005780:Gelatin; D003094:Collagen; C020243:calcium phosphate; D006909:Hydroxyproline