title: Angiogenesis in salivary carcinomas with and without myoepithelial differentiation.
abstract: To investigate whether salivary carcinomas with and without myoepithelial differentiation could present differences regarding degree of angiogenesis, we compared tumor vascularization between adenoid cystic (31 cases) and epithelial-myoepithelial carcinomas (14) versus mucoepidermoid (37) carcinoma. The expression of peroxiredoxin I was also studied to verify the potential relationship between cellular metabolism and microvascular density. Microvascular density for CD34 and CD105 were significantly lower in carcinomas with myoepithelial differentiation. However, no correlation was found between degree of angiogenesis and amounts of myoepithelial cells. High-grade peroxiredoxin I expression was found in 73.7% of mucoepidermoid carcinomas, whereas 85.1% of carcinomas with myoepithelial differentiation presented low-grade expression. In conclusion, carcinomas with myoepithelial differentiation, regardless of the amounts of myoepithelial cells, are associated to a significantly lower vascular density. The reasons for this lower angiogenic activity remain to be determined but could be related to metabolic characteristics of the cancer cells.
authors.affiliation: Department of Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, Sao Paulo, Brazil.
authors.forename: A F
authors.initials: AF
authors.lastname: Costa
authors.forename: A P D
authors.initials: AP
authors.lastname: Demasi
authors.forename: V L L
authors.initials: VL
authors.lastname: Bonfitto
authors.forename: J F L
authors.initials: JF
authors.lastname: Bonfitto
authors.forename: C
authors.initials: C
authors.lastname: Furuse
authors.forename: V C
authors.initials: VC
authors.lastname: Araújo
authors.forename: K
authors.initials: K
authors.lastname: Metze
authors.forename: A
authors.initials: A
authors.lastname: Altemani
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000378:metabolism; D018952:Antigens, CD34 / Q000378:metabolism; D003528:Carcinoma, Adenoid Cystic / Q000473:pathology; D018277:Carcinoma, Mucoepidermoid / Q000473:pathology; D002454:Cell Differentiation; D000071063:Endoglin; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009208:Myoepithelioma / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000473:pathology*; D011956:Receptors, Cell Surface / Q000378:metabolism; D012468:Salivary Gland Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D015703:Antigens, CD; D018952:Antigens, CD34; C064206:ENG protein, human; D000071063:Endoglin; D011956:Receptors, Cell Surface
references.citation: J Surg Oncol. 2006 May 1;93(6):446-55
references.pmid: 16615157
references.citation: FASEB J. 2003 Jun;17(9):984-92
references.pmid: 12773481
references.citation: Br J Cancer. 2000 Feb;82(4):844-51
references.pmid: 10732757
references.citation: Cancer Metastasis Rev. 1990 Nov;9(3):171-4
references.pmid: 1705485
references.citation: Nat Biotechnol. 1997 Aug;15(8):778-83
references.pmid: 9255794
references.citation: J Pathol. 1996 Apr;178(4):363-6
references.pmid: 8691311
references.citation: Cancer Res. 1994 Jul 1;54(13):3333-6
references.pmid: 8012945
references.citation: Virchows Arch. 2007 Jul;451(1):65-71
references.pmid: 17593387
references.citation: APMIS. 2004 Jul-Aug;112(7-8):413-30
references.pmid: 15563306
references.citation: J Clin Pathol. 1998 Jul;51(7):506-11
references.pmid: 9797726
references.citation: BMC Cancer. 2007 Jun 01;7:95
references.pmid: 17543095
references.citation: Anticancer Res. 2001 Nov-Dec;21(6B):4311-6
references.pmid: 11908685
references.citation: Microsc Res Tech. 2001 Feb 15;52(4):437-49
references.pmid: 11170303
references.citation: Science. 2003 Apr 25;300(5619):650-3
references.pmid: 12714747
references.citation: Semin Cancer Biol. 2003 Apr;13(2):159-67
references.pmid: 12654259
references.citation: J Cell Sci. 2003 Jul 1;116(Pt 13):2677-85
references.pmid: 12746487
references.citation: J Mammary Gland Biol Neoplasia. 2005 Jul;10(3):249-60
references.pmid: 16807804
references.citation: Nature. 2000 Nov 9;408(6809):239-47
references.pmid: 11089981
references.citation: Prog Histochem Cytochem. 2003;38(4):343-426
references.pmid: 14509196
references.citation: Hum Pathol. 2006 Jul;37(7):861-6
references.pmid: 16784986
references.citation: J Clin Oncol. 1995 Mar;13(3):765-82
references.pmid: 7533829
references.citation: BMC Cancer. 2006 May 02;6:110
references.pmid: 16650286
references.citation: J Natl Cancer Inst. 2002 Jun 19;94(12):883-93
references.pmid: 12072542
references.citation: World J Gastroenterol. 2003 Jun;9(6):1144-55
references.pmid: 12800214
references.citation: Int J Cancer. 1993 May 28;54(3):363-70
references.pmid: 8509210
references.citation: Oncogene. 2000 Jul 20;19(31):3449-59
references.pmid: 10918603
references.citation: J Cell Physiol. 2001 Jul;188(1):1-7
references.pmid: 11382917
references.citation: J Biol Chem. 1999 Jan 8;274(2):584-94
references.pmid: 9872992
references.citation: Anticancer Res. 1998 Sep-Oct;18(5A):3621-8
references.pmid: 9858949
references.citation: Int J Surg Pathol. 2005 Jan;13(1):57-65
references.pmid: 15735856