title: 5-HT2C receptor agonists with potential anorectic activity.
abstract: Substituted 2,3,4,4a-tetrahydropyrazino[2,1-c][1,4]benzoxazin-5-(1H)-ones were synthesized and evaluated as 5-HT(2C) receptor agonists for the possible treatment of obesity. A number of compounds exhibited 5-HT(2C) agonist binding activity with compound 19 showing the most potent in vitro activity.
authors.affiliation: College of Pharmacy and Research Institute of Drug Development, Chonnam National University, 300 Yongbong-Dong, BukGu, Gwangju 500-757, Korea.
authors.forename: Goo
authors.initials: G
authors.lastname: Yoon
authors.forename: Hee Jin
authors.initials: HJ
authors.lastname: Jeong
authors.forename: Jeong Ju
authors.initials: JJ
authors.lastname: Kim
authors.forename: Seung Hoon
authors.initials: SH
authors.lastname: Cheon
mesh_terms: D000818:Animals; D001067:Appetite Depressants / Q000138:chemical synthesis* / Q000494:pharmacology*; D048588:Benzoxazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D016466:CHO Cells; D002855:Chromatography, Thin Layer; D006224:Cricetinae; D003412:Cricetulus; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D011719:Pyrazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D044405:Receptor, Serotonin, 5-HT2C / Q000187:drug effects*; D017366:Serotonin Receptor Agonists / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D001067:Appetite Depressants; D048588:Benzoxazines; D007202:Indicators and Reagents; D011719:Pyrazines; D044405:Receptor, Serotonin, 5-HT2C; D017366:Serotonin Receptor Agonists