title: Efficient iron-catalyzed N-arylation of aryl halides with amines.
abstract: A practical and promising protocol was developed for N-arylations of various amines with differently substituted aryl halides. The processes are efficiently promoted by the catalyst system involving the environmentally benign Fe2O3 and the universal ligand L-proline. The versatility, convenient operation, low cost, and environmental friendliness, in combination with the high yields, render this method viable for use in both laboratory research and larger industrial scales.
authors.affiliation: Drug Discovery and Design Centre, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
authors.forename: Diliang
authors.initials: D
authors.lastname: Guo
authors.forename: He
authors.initials: H
authors.lastname: Huang
authors.forename: Jinyi
authors.initials: J
authors.lastname: Xu
authors.forename: Hualiang
authors.initials: H
authors.lastname: Jiang
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
mesh_terms: D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D006219:Halogens / Q000737:chemistry*; D007501:Iron / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000588:Amines; D006219:Halogens; D007501:Iron