title: [Expression of cyclin G1 in laryngeal squamous cell carcinoma and its clinicopathologic significance].
abstract: OBJECTIVE
  To evaluate the expression of cyclin G1 and its relationship with clinical pathological characters, p53 expression and microvessel density (MVD) in laryngeal squamous cell carcinoma (LSCC), and to investigate the prognostic value of cyclin G1 in LSCC.
  
  
  METHODS
  Using immunohistochemistry, 81 cases of LSCC were evaluated for cyclin G1 and p52 expression, MVD was assessed by CD34 staining. In 20 cases, similar assessment was made in the adjacent normal mucosa.
  
  
  RESULTS
  Compared to the normal laryngeal mucosa, the expressions of cyclin Gl, p53 and MVD were higher in LSCC than that in normal tissues. The positive rates of cyclin G1 and p53 expressions in LSCC were 61.7% (50/81) and 65.4% (53/81), respectively. The positive rates of cyclin G1 in LSCC with or without p53 expression were 71.7% (38/53) and 42.9% (12/28), respectively. The expression of cyclin G1 was significantly correlated with p53 (P = 0.011). The mean value of MVD was (51.23 +/- 16.46 mv) in cyclin G1 positive group, and(30.74 +/- 12.29 mv) in the negative group, and the difference was significant (P = 0.005). Furthermore, the over-expression of cyclin G1 was related to the histological grade, cervical lymph node metastases and 5 year survival (P = 0.002, 0.013 and 0.032 respectively).
  
  
  CONCLUSIONS
  Cyclin G1 is highly expressed in laryngeal squamous cell carcinoma, and is associated with the expression of p53 protein and tumor angiogenesis. It may play an important role in carcinogenesis and metastasis in LSCC, and may be one of prognostic indices for LSCC patients.
authors.affiliation: Department of Pathogenic Biology, College of Public Health and Tropical Disease, Southern Medical University, Guangzhou 510515, China.
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Cui
authors.forename: Ai-Jun
authors.initials: AJ
authors.lastname: Liu
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Wei
authors.forename: Xiao-Guang
authors.initials: XG
authors.lastname: Chen
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000378:metabolism; D056766:Cyclin G1 / Q000235:genetics / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism*; D008198:Lymph Nodes / Q000378:metabolism*; D008207:Lymphatic Metastasis / Q000175:diagnosis*; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D056766:Cyclin G1; D018809:Proliferating Cell Nuclear Antigen