Brain serotonin transporter binding of [123I]ADAM: within-subject variation between summer and winter data.
The neurotransmitter serotonin (5-HT) controls several physiological functions, and a disturbance of the 5-HT system is implicated in many psychiatric conditions. Seasonal variation has been suggested in the 5-HT system. We investigated within-subject seasonal variation in brain serotonin transporter (SERT) binding with the SERT-ligand [(123)I]ADAM and single photon emission computed tomography (SPECT) in 12 healthy individuals. No systematic variation was found in the midbrain or thalamus areas between scans done in summer and winter. Our results suggest that factors other than season are more important in causing within-subject variation of brain SERT binding between summer and winter.
Koskela
Anu
A
Department of Clinical Physiology and Nuclear Medicine, HUSLAB/Helsinki University Central Hospital, Helsinki, Finland. anu.koskela@helsinki.fi
Kauppinen
Tomi
T
Keski-Rahkonen
Anna
A
Sihvola
Elina
E
Kaprio
Jaakko
J
Rissanen
Aila
A
Ahonen
Aapo
A
D051722:ADAM Proteins / Q000378:metabolism*; D000328:Adult; D001921:Brain / Q000378:metabolism*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D011485:Protein Binding; D012621:Seasons; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*
D007457:Iodine Radioisotopes; D050486:Serotonin Plasma Membrane Transport Proteins; D051722:ADAM Proteins