title: Circadian phase resetting via single and multiple control targets.
abstract: Circadian entrainment is necessary for rhythmic physiological functions to be appropriately timed over the 24-hour day. Disruption of circadian rhythms has been associated with sleep and neuro-behavioral impairments as well as cancer. To date, light is widely accepted to be the most powerful circadian synchronizer, motivating its use as a key control input for phase resetting. Through sensitivity analysis, we identify additional control targets whose individual and simultaneous manipulation (via a model predictive control algorithm) out-perform the open-loop light-based phase recovery dynamics by nearly 3-fold. We further demonstrate the robustness of phase resetting by synchronizing short- and long-period mutant phenotypes to the 24-hour environment; the control algorithm is robust in the presence of model mismatch. These studies prove the efficacy and immediate application of model predictive control in experimental studies and medicine. In particular, maintaining proper circadian regulation may significantly decrease the chance of acquiring chronic illness.
authors.affiliation: Department of Electrical and Computer Engineering, University of California Santa Barbara, Santa Barbara, California, USA.
authors.forename: Neda
authors.initials: N
authors.lastname: Bagheri
authors.forename: Jörg
authors.initials: J
authors.lastname: Stelling
authors.forename: Francis J
authors.initials: FJ
authors.lastname: Doyle
mesh_terms: D000465:Algorithms; D000818:Animals; D002940:Circadian Rhythm; D004331:Drosophila melanogaster / Q000502:physiology; D008027:Light
references.citation: J Neurosci. 2001 Sep 1;21(17):6644-56
references.pmid: 11517254
references.citation: J Biol Rhythms. 1998 Feb;13(1):70-87
references.pmid: 9486845
references.citation: J Biol Rhythms. 2005 Aug;20(4):375-86
references.pmid: 16077156
references.citation: Cell. 2003 Feb 7;112(3):329-41
references.pmid: 12581523
references.citation: Nat Neurosci. 2005 Mar;8(3):267-9
references.pmid: 15746913
references.citation: J Physiol. 2003 Jun 15;549(Pt 3):945-52
references.pmid: 12717008
references.citation: Proc Natl Acad Sci U S A. 2007 May 22;104(21):9081-6
references.pmid: 17502598
references.citation: Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13210-5
references.pmid: 15340155
references.citation: Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7051-6
references.pmid: 12775757
references.citation: Nat Cell Biol. 2003 Oct;5(10):859-61
references.pmid: 14523398
references.citation: Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14806-11
references.pmid: 14657377
references.citation: Cancer. 2003 Jan 1;97(1):155-69
references.pmid: 12491517
references.citation: Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):673-8
references.pmid: 11792856
references.citation: Bioinformatics. 2007 Feb 1;23(3):358-64
references.pmid: 17158515
references.citation: Science. 2003 Oct 10;302(5643):255-9
references.pmid: 12934012
references.citation: J R Soc Interface. 2008 Aug 6;5 Suppl 1:S17-28
references.pmid: 18426774
references.citation: Proc Natl Acad Sci U S A. 2006 May 9;103(19):7414-9
references.pmid: 16648247
references.citation: IET Syst Biol. 2008 Jan;2(1):16-23
references.pmid: 18248082
references.citation: J Theor Biol. 2004 Oct 21;230(4):521-32
references.pmid: 15363673
references.citation: Science. 2006 Aug 4;313(5787):644-9
references.pmid: 16809488
references.citation: Cancer Res. 2003 Nov 15;63(22):7545-52
references.pmid: 14633665
references.citation: Biophys J. 2005 Apr;88(4):2530-40
references.pmid: 15695639
references.citation: Am J Physiol Endocrinol Metab. 2004 Jul;287(1):E174-81
references.pmid: 15039146
references.citation: Nat Rev Neurosci. 2003 Aug;4(8):649-61
references.pmid: 12894240
references.citation: J Neurosci. 2002 Sep 1;22(17):7326-30
references.pmid: 12196553
references.citation: Nat Rev Cancer. 2003 May;3(5):350-61
references.pmid: 12724733
references.citation: EMBO Rep. 2006 Feb;7(2):199-204
references.pmid: 16374510
references.citation: Nature. 1996 Feb 8;379(6565):540-2
references.pmid: 8596632
references.citation: Aviat Space Environ Med. 2002 Oct;73(10):953-63
references.pmid: 12398256
references.citation: Nat Cell Biol. 2007 Nov;9(11):1327-34
references.pmid: 17952058
references.citation: Mol Syst Biol. 2006;2:58
references.pmid: 17102803