In vitro activities at pH 5.0 and pH 7.0 and in vivo efficacy of flucytosine against Aspergillus fumigatus.
The antifungal agent flucytosine was found to be active in vitro against Aspergillus fumigatus isolates when the MIC was determined at pH 5.0 instead of pH 7.0. The in vitro MIC at pH 5.0 corresponded to the in vivo efficacy of flucytosine monotherapy in a murine model of invasive aspergillosis.
Verweij
Paul E
PE
Department of Medical Microbiology, Radboud University Nijmegen Medical Center, P.O. Box 9101, Nijmegen 6500 HB, The Netherlands. p.verweij@mmb.umcn.nl
Te Dorsthorst
Debbie T A
DT
Janssen
Willem H P
WH
Meis
Jacques F G M
JF
Mouton
Johan W
JW
D000818:Animals; D021461:Animals, Outbred Strains; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy* / Q000382:microbiology; D001232:Aspergillus fumigatus / Q000187:drug effects*; D004195:Disease Models, Animal; D005260:Female; D005437:Flucytosine / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D006863:Hydrogen-Ion Concentration; D051379:Mice; D008826:Microbial Sensitivity Tests; D016896:Treatment Outcome
D000935:Antifungal Agents; D005437:Flucytosine
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