5-HT2C receptor agonists with potential anorectic activity.
Substituted 2,3,4,4a-tetrahydropyrazino[2,1-c][1,4]benzoxazin-5-(1H)-ones were synthesized and evaluated as 5-HT(2C) receptor agonists for the possible treatment of obesity. A number of compounds exhibited 5-HT(2C) agonist binding activity with compound 19 showing the most potent in vitro activity.
Yoon
Goo
G
College of Pharmacy and Research Institute of Drug Development, Chonnam National University, 300 Yongbong-Dong, BukGu, Gwangju 500-757, Korea.
Jeong
Hee Jin
HJ
Kim
Jeong Ju
JJ
Cheon
Seung Hoon
SH
D000818:Animals; D001067:Appetite Depressants / Q000138:chemical synthesis* / Q000494:pharmacology*; D048588:Benzoxazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D016466:CHO Cells; D002855:Chromatography, Thin Layer; D006224:Cricetinae; D003412:Cricetulus; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D011719:Pyrazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D044405:Receptor, Serotonin, 5-HT2C / Q000187:drug effects*; D017366:Serotonin Receptor Agonists / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D001067:Appetite Depressants; D048588:Benzoxazines; D007202:Indicators and Reagents; D011719:Pyrazines; D044405:Receptor, Serotonin, 5-HT2C; D017366:Serotonin Receptor Agonists