title: [Short stature in chronic kidney disease: physiopathology and treatment with growth hormone].
abstract: Growth failure is frequent and a clinically important issue in children with chronic kidney disease (CKD). Many factors contribute to impaired growth in these children, including abnormalities in the growth hormone (GH)--insulin-like growth factor 1 (IGF-1) axis, malnutrition, acidosis, renal bone disease and glucocorticoid associated treatment. The management of growth failure in children with CKD is complicated by the presence of other-disease related complications requiring medical intervention. Despite evidence of GH efficacy and safety in this population, this therapy is still underutilized. This review shows the impact, the causes and the treatment of growth failure in children with CKD.
authors.affiliation: Clínica Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brazil.
authors.forename: Josenilson Campos de
authors.initials: JC
authors.lastname: Oliveira
authors.forename: Adriana A
authors.initials: AA
authors.lastname: Siviero-Miachon
authors.forename: Angela Maria
authors.initials: AM
authors.lastname: Spinola-Castro
authors.forename: Vera Maria Santoro
authors.initials: VM
authors.lastname: Belangero
authors.forename: Gil
authors.initials: G
authors.lastname: Guerra-Junior
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D001827:Body Height / Q000187:drug effects; D006130:Growth Disorders / Q000188:drug therapy* / Q000503:physiopathology; D019382:Human Growth Hormone / Q000378:metabolism / Q000627:therapeutic use*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007676:Kidney Failure, Chronic / Q000150:complications*
chemical_list: D000305:Adrenal Cortex Hormones; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I