title: A simple clinico-histopathological composite scoring system is highly predictive of graft outcomes in marginal donors.
abstract: The predictive value of pre-implantation biopsies versus clinical scores has not been studied extensively in marginal donors. Pre-implantation biopsies were performed in 313 kidneys from donors that were > or = 50 years of age (training set, n = 191; validation set, n = 122). The value of the donor clinical parameters and histological results in predicting 1-year estimated glomerular filtration rate (eGFR) <25 mL/min/1.73 m(2) was retrospectively evaluated. In multivariate analysis, the only clinical parameters associated with low eGFR were donor hypertension and a serum creatinine level > or =150 micromol/L before organ recovery. Clinical scores (Nyberg and Pessione) were not significantly associated with graft function. Regarding histological parameters, univariate analysis showed that glomerulosclerosis (GS) (p = 0.02), arteriolar hyalinosis (p = 0.03) and the Pirani (p = 0.02) and chronic allograft damage index (CADI) (p = 0.04) histological scores were associated with low eGFR. The highest performance in predicting low eGFR was achieved using a composite score that included donor serum creatinine (> or =150 micromol/L or <150 micromol/L), donor hypertension and GS (> or =10% or <10%). The validation set confirmed the critical importance of taking into account biopsy and clinical parameters during marginal donor evaluation. In conclusion, clinical scores are weak predictors of graft outcomes with marginal donors. Instead, a simple and convenient composite score strongly predicts graft function and survival and may facilitate optimal allocation of marginal donors.
authors.affiliation: Service de Transplantation Rénale et de Soins Intensifs, Hôpital Necker, APHP, Paris, F-75015 France. dany.anglicheau@nck.aphp.fr
authors.forename: D
authors.initials: D
authors.lastname: Anglicheau
authors.forename: A
authors.initials: A
authors.lastname: Loupy
authors.forename: C
authors.initials: C
authors.lastname: Lefaucheur
authors.forename: F
authors.initials: F
authors.lastname: Pessione
authors.forename: I
authors.initials: I
authors.lastname: Létourneau
authors.forename: I
authors.initials: I
authors.lastname: Côté
authors.forename: K
authors.initials: K
authors.lastname: Gaha
authors.forename: L-H
authors.initials: LH
authors.lastname: Noël
authors.forename: N
authors.initials: N
authors.lastname: Patey
authors.forename: D
authors.initials: D
authors.lastname: Droz
authors.forename: F
authors.initials: F
authors.lastname: Martinez
authors.forename: J
authors.initials: J
authors.lastname: Zuber
authors.forename: D
authors.initials: D
authors.lastname: Glotz
authors.forename: E
authors.initials: E
authors.lastname: Thervet
authors.forename: C
authors.initials: C
authors.lastname: Legendre
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D005923:Glomerulosclerosis, Focal Segmental / Q000473:pathology; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007668:Kidney / Q000473:pathology; D016030:Kidney Transplantation / Q000379:methods* / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D003404:Creatinine