title: Pathological and phylogenetic features of prevalent canine distemper viruses in wild masked palm civets in Japan.
abstract: Ten wild masked palm civets infected with canine distemper virus (CDV), captured in Japan from 2005 to 2007, were histopathologically and phylogenetically analyzed. Phylogenetic analysis based on the amino acid sequences of the H protein of two CDV isolates from masked palm civets revealed that the two isolates were classified into the clade of recent isolates in Japan. Histopathologically marked lesions of virus encephalitis were present in the brain, whereas gastrointestinal lesions were absent or at a mild degree. The distribution of the lesions resembles that of recent CDV cases in dogs. Therefore, recent CDV infections in masked palm civets could be caused by recently prevalent CDV in dogs. The possibility of the masked palm civet as a spreader of CDV among wildlife is also discussed.
authors.affiliation: Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.
authors.forename: Ikuyo
authors.initials: I
authors.lastname: Takayama
authors.forename: Masahito
authors.initials: M
authors.lastname: Kubo
authors.forename: Akiko
authors.initials: A
authors.lastname: Takenaka
authors.forename: Kentaro
authors.initials: K
authors.lastname: Fujita
authors.forename: Takaaki
authors.initials: T
authors.lastname: Sugiyama
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Arai
authors.forename: Misako
authors.initials: M
authors.lastname: Yoneda
authors.forename: Hiroki
authors.initials: H
authors.lastname: Sato
authors.forename: Tokuma
authors.initials: T
authors.lastname: Yanai
authors.forename: Chieko
authors.initials: C
authors.lastname: Kai
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000473:pathology / Q000821:virology; D004216:Distemper / Q000150:complications / Q000453:epidemiology* / Q000473:pathology*; D004217:Distemper Virus, Canine / Q000235:genetics* / Q000302:isolation & purification; D018792:Encephalitis, Viral / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D005260:Female; D041981:Gastrointestinal Tract / Q000473:pathology / Q000821:virology; D005814:Genes, Viral; D007564:Japan / Q000453:epidemiology; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D015995:Prevalence; D020539:Sequence Analysis, Protein; D045949:Viverridae / Q000821:virology*