title: Reengineering clinical research science: a focus on translational research.
abstract: The burden of disease in the United States is high. Mental illness is currently the leading cause of disease burden among 15- to 44-year-olds. This phenomenon is occurring despite the many advances that have been made in clinical research. Several efficacious interventions are available to treat many of these disorders; however, they are greatly underutilized within community settings. Achievements in basic science such as the completion of the Human Genome project have provided access to the examination of the neurobiology of mental disorders. To address the overall burden of disease, a reengineering of clinical science must take place. Adopting a translational framework will capitalize on the synergy of integrating basic science and clinical knowledge to inform real-world practices. This article will define and discuss translational research and the current National Institutes of Health initiatives that have been developed to support its implementation.
authors.affiliation: Developmental Traslational Research, National Institute of Mental Health, Bethesda, MD 20892-9617, USA. cferrell@mail.nih.gov
authors.forename: Courtney B
authors.initials: CB
authors.lastname: Ferrell
mesh_terms: D001690:Biological Science Disciplines / Q000379:methods; D035843:Biomedical Research / Q000193:education / Q000379:methods; D015510:Clinical Medicine; D003144:Communication Barriers; D017281:Cost of Illness; D004059:Diffusion of Innovation; D006801:Humans; D001523:Mental Disorders / Q000628:therapy; D009315:National Institute of Mental Health (U.S.); D009316:National Institutes of Health (U.S.); D012109:Research Support as Topic; D014481:United States