[Volume regulated anion channel and ischemia/reperfusion injury of myocardium].
It has been shown that a lot of diseases were related with the change or loss of Cl- channel functions. Among the Cl- channels, volume-regulated anion channel (VRAC) plays important roles in myocardial ischemia/reperfusion injury, cardiac arrhythmia and apoptosis; it may become a new target in the clinical treatment of heart diseases. This paper presents an overview of the physiological characteristics of VRAC and its relations with myocardial ischemia/reperfusion injury.
Li
Ping
P
Department of Emergency, China-Japan Union Hospital, Jilin University, Changchun 130033, China.
Sun
Xiaoli
X
D018118:Chloride Channels / Q000145:classification / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D015428:Myocardial Reperfusion Injury / Q000378:metabolism*
D018118:Chloride Channels