Identification of a methioninase inhibitor, myrsinoic acid B, from Myrsine seguinii Lév., and its inhibitory activities.
A methioninase inhibitor from Myrsine seguinii was purified and identified as myrsinoic acid B. Its inhibitory activities as to crude methioninase from periodontal bacteria such as Fusobacterium nucleatum, Porphyromonas gingivalis, and Treponema denticola were determined. The IC50 values were 10.5, 82.4, and 30.3 microM respectively.
Ito
Satomi
S
Central Laboratory, Lotte Co., Ltd, Saitama, Japan. itou_satomi@lotte.co.jp
Narise
Atsushi
A
Shimura
Susumu
S
D000475:Alkenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001572:Benzofurans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002087:Butyrates / Q000037:antagonists & inhibitors; D013437:Carbon-Sulfur Lyases / Q000037:antagonists & inhibitors*; D016967:Fusobacterium nucleatum / Q000378:metabolism; D020128:Inhibitory Concentration 50; D008767:Methylmercury Compounds / Q000037:antagonists & inhibitors; D015394:Molecular Structure; D010518:Periodontitis / Q000382:microbiology; D016966:Porphyromonas gingivalis / Q000378:metabolism; D029623:Primulaceae / Q000737:chemistry*; D013045:Species Specificity; D048373:Treponema denticola / Q000378:metabolism
D000475:Alkenes; D001572:Benzofurans; D002087:Butyrates; D008767:Methylmercury Compounds; C468150:myrsinoic acid B; C005087:alpha-ketobutyric acid; D013437:Carbon-Sulfur Lyases; C021558:L-methionine gamma-lyase