title: Assessment of Hematological and Biochemical parameters with extended D-Ribose ingestion.
abstract: D-ribose, a naturally occurring pentose carbohydrate, has been shown to replenish high- energy phosphates following myocardial ischemia and high intensity, repetitive exercise. Human studies have mainly involved short-term assessment, including potential toxicity. Reports describing adverse effects of D-ribose with prolonged ingestion have been lacking. Therefore, this study assessed the toxicity of extended consumption of D-ribose in healthy adults. Nineteen subjects ingested 20 grams/Day (10 grams, twice a Day) of ribose with serial measurements of biochemical and hematological parameters at Days 0, 7, and 14. No significant toxic changes over the 14-day assessment period occurred in complete blood count, albumin, alkaline phosphatase, gamma glutamyltransferase, alanine amiotransferase, and aspartate aminotransferase. However, D-ribose did produce an asymptomatic, mild hypoglycemia of short duration. Uric acid levels increased at Day 7, but decreased to baseline values by Day 14. D-ribose consumption for 14 days appears not to produce significant toxic changes in both hematological and biochemical parameters in healthy human volunteers.
authors.affiliation: Human Performance Laboratory, St. Cloud State University, St. Cloud, MN, USA. jgseifert@stcloudstate.edu
authors.forename: John
authors.initials: J
authors.lastname: Seifert
authors.forename: Angela
authors.initials: A
authors.lastname: Frelich
authors.forename: Linda
authors.initials: L
authors.lastname: Shecterle
authors.forename: John
authors.initials: J
authors.lastname: St Cyr
references.citation: Eur J Heart Fail. 2003 Oct;5(5):615-9
references.pmid: 14607200
references.citation: Lancet. 1992 Aug 29;340(8818):507-10
references.pmid: 1354276
references.citation: Am J Physiol. 1991 Aug;261(2 Pt 1):C342-7
references.pmid: 1908187
references.citation: Nihon Rinsho. 1996 Dec;54(12):3188-94
references.pmid: 8976090
references.citation: Am J Physiol Regul Integr Comp Physiol. 2004 Jan;286(1):R182-8
references.pmid: 14660478
references.citation: J Appl Physiol (1985). 2001 Jul;91(1):231-8
references.pmid: 11408435
references.citation: Klin Wochenschr. 1991 Jan 4;69(1):31-6
references.pmid: 1901925
references.citation: Food Chem Toxicol. 2007 Jan;45(1):144-52
references.pmid: 17011102
references.citation: Int J Sport Nutr Exerc Metab. 2003 Mar;13(1):76-86
references.pmid: 12660407
references.citation: J Appl Physiol (1985). 2001 Oct;91(4):1775-81
references.pmid: 11568162
references.citation: J Strength Cond Res. 2003 Feb;17(1):47-52
references.pmid: 12580655
references.citation: Proc Soc Exp Biol Med. 1957 Jul;95(3):551-5
references.pmid: 13453503
references.citation: Clin J Sport Med. 2006 Jan;16(1):68-71
references.pmid: 16377979
references.citation: J Appl Physiol (1985). 2001 Nov;91(5):2275-81
references.pmid: 11641371
references.citation: J Strength Cond Res. 2006 Aug;20(3):519-22
references.pmid: 16937963
references.citation: Int J Sport Nutr Exerc Metab. 2005 Dec;15(6):653-64
references.pmid: 16521849
references.citation: J Clin Invest. 1958 May;37(5):719-35
references.pmid: 13539215
references.citation: Pharm World Sci. 1994 Apr 15;16(2):40-54
references.pmid: 8032341
references.citation: J Mol Cell Cardiol. 1984 Sep;16(9):863-6
references.pmid: 6436498
references.citation: Am J Physiol. 1988 Sep;255(3 Pt 1):C271-7
references.pmid: 3421309