title: Thyroid volume is associated with family history of thyroid disease in pregnant women with adequate iodine intake: a cross-sectional study in southern Brazil.
abstract: Maternal euthyroidism is important for fetal neural development. For this reason, adequate iodine nutrition during pregnancy is an important public health objective and should be periodically revised. The objective of this study was to measure urinary iodine (UI) excretion and the factors associated with thyroid volume (TV), in a group of healthy pregnant women in southern Brazil, to evaluate iodine nutrition. The median UI of the 147 women was 224 microg/l (P25=164 microg/l and P75=286 microg/l). Serum levels of free T4 and thyroglobulin did not correlate with UI, but there was a weak inverse correlation between serum TSH levels and UI (r=-0.200; p=0.02). TV, calculated through ultrasound in 57 women, was significantly associated with family history of thyroid diseases (p=0.002) and BMI (p=0.03), but there was no association with UI, corrected or not for creatinine, serum free T4, TSH or thyroglobulin, current or past smoking, gestational age, parity or oral contraceptive.
  
  
  CONCLUSIONS
  The healthy pregnant women studied had adequate iodine intake. In this situation, the main thyroid size determinants are probably genetic factors.
authors.affiliation: Post-Graduation Program in Medicine: Medical Sciences, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: R
authors.initials: R
authors.lastname: Soares
authors.forename: R
authors.initials: R
authors.lastname: Vanacor
authors.forename: D
authors.initials: D
authors.lastname: Manica
authors.forename: L B
authors.initials: LB
authors.lastname: Dorneles
authors.forename: V L
authors.initials: VL
authors.lastname: Resende
authors.forename: M C
authors.initials: MC
authors.lastname: Bertoluci
authors.forename: T W
authors.initials: TW
authors.lastname: Furlanetto
mesh_terms: D000328:Adult; D001938:Brazil; D003430:Cross-Sectional Studies; D004032:Diet; D005260:Female; D005865:Gestational Age; D006801:Humans; D007455:Iodine / Q000378:metabolism*; D039382:Maternal Nutritional Physiological Phenomena; D011247:Pregnancy; D013954:Thyroglobulin / Q000097:blood; D013959:Thyroid Diseases / Q000097:blood* / Q000652:urine; D013961:Thyroid Gland / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D014284:Triiodothyronine; D013954:Thyroglobulin; D007455:Iodine; D013974:Thyroxine
references.citation: Endocr Pract. 2002 Jan-Feb;8(1):23-8
references.pmid: 11939756
references.citation: Clin Chem. 1996 Feb;42(2):239-43
references.pmid: 8595717
references.citation: Clin Endocrinol (Oxf). 2000 Nov;53(5):629-34
references.pmid: 11106925
references.citation: J Clin Ultrasound. 2002 May;30(4):226-31
references.pmid: 11981932
references.citation: Eur J Clin Nutr. 1999 May;53(5):401-7
references.pmid: 10369497
references.citation: N Engl J Med. 1999 Aug 19;341(8):549-55
references.pmid: 10451459
references.citation: J Endocrinol Invest. 2002 May;25(5):442-6
references.pmid: 12035941
references.citation: Arq Bras Endocrinol Metabol. 2004 Dec;48(6):842-8
references.pmid: 15761558
references.citation: J Clin Endocrinol Metab. 2000 Dec;85(12):4534-7
references.pmid: 11134104
references.citation: Endocr Rev. 1997 Jun;18(3):404-33
references.pmid: 9183570
references.citation: J Clin Endocrinol Metab. 2004 May;89(5):2071-7
references.pmid: 15126523
references.citation: N Engl J Med. 2004 Jul 15;351(3):241-9
references.pmid: 15254282
references.citation: J Endocrinol Invest. 2003 May;26(5):389-96
references.pmid: 12906364
references.citation: Best Pract Res Clin Endocrinol Metab. 2004 Jun;18(2):133-52
references.pmid: 15157832
references.citation: Thyroid. 1999 Nov;9(11):1069-74
references.pmid: 10595454
references.citation: Clin Endocrinol (Oxf). 1994 Sep;41(3):375-9
references.pmid: 7955445
references.citation: J Clin Endocrinol Metab. 2000 Apr;85(4):1367-9
references.pmid: 10770167
references.citation: Eur J Endocrinol. 2004 Nov;151 Suppl 3:U25-37
references.pmid: 15554884
references.citation: Exp Clin Endocrinol Diabetes. 2005 Oct;113(9):507-15
references.pmid: 16235152
references.citation: Public Health Nutr. 2007 Dec;10(12A):1606-11
references.pmid: 18053287