C-Reactive protein, insulin resistance, and metabolic syndrome in a population with a high burden of subclinical infection: insights from the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study.
OBJECTIVE
To explore relationships between C-reactive protein (CRP), subclinical infection, insulin resistance, and metabolic syndrome.


METHODS
Data from 1,174 Eskimos, aged >/=18 years, from the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study were analyzed; 40 participants with diabetes were eliminated. Baseline assessment included interviews, physical exam, and blood and urine sampling. Metabolic syndrome was assessed using Adult Treatment Panel III criteria. CRP and antibodies to common pathogens were measured.


RESULTS
Although CRP was related in univariate analyses to insulin resistance and metabolic syndrome, relations were attenuated or eliminated after adjustment for relevant covariates. CRP was not higher among those with impaired fasting glucose (IFG), and pathogen burden was not related to insulin resistance, metabolic syndrome, or IFG.


CONCLUSIONS
Pathogen burden and inflammation do not seem to be related to insulin resistance, metabolic syndrome, or IFG in this population. The inflammatory process may reflect insulin resistance or its correlates but most likely is not causative.
Howard
Barbara V
BV
MedStar Research Institute, Hyattsville, Maryland, USA. barbara.v.howard@medstar.net
Best
Lyle
L
Comuzzie
Anthony
A
Ebbesson
Sven O E
SO
Epstein
Stephen E
SE
Fabsitz
Richard R
RR
Howard
Wm James
WJ
Silverman
Angela
A
Wang
Hong
H
Zhu
Jianhui
J
Umans
Jason
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000032:analysis*; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000209:etiology / Q000276:immunology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000453:epidemiology* / Q000209:etiology; D007333:Insulin Resistance / Q000276:immunology / Q000502:physiology*; D004930:Inuit; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000276:immunology; D008875:Middle Aged
D002097:C-Reactive Protein
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