title: Differences in the expression pattern of P-glycoprotein and MRP1 in low-grade and high-grade gliomas.
abstract: Multidrug resistance in gliomas is the major challenges in the clinical setting. We investigated the expression of P-glycoprotein (Pgp) and multidrug resistance-related protein 1 (MRP1) in 50 gliomas using immunohistochemistry. Compared to Pgp, MRP1 positivity was observed in highest percentage of gliomas grade IV samples (p = 0.008). Unlike MRP1 expression observed in high-grade, gliomas grade II exhibited a greater number of Pgp positive samples as compared to grades III and IV (p = 0.026). Our results suggest that the difference between the histological grade gliomas regarding MRP1 and Pgp expression must have implications in the choice of chemotherapeutic protocols.
authors.affiliation: Laboratório de Hematologia Celular e Molecular, Serviço de Hematologia, Hospital do Câncer, Instituto Nacional de Câncer, Rio de Janeiro, Brazil.
authors.forename: Giselle Pinto
authors.initials: GP
authors.lastname: de Faria
authors.forename: José Antônio
authors.initials: JA
authors.lastname: de Oliveira
authors.forename: José Gustavo Pugliese
authors.initials: JG
authors.lastname: de Oliveira
authors.forename: Sérgio de Oliveira
authors.initials: Sde O
authors.lastname: Romano
authors.forename: Vivaldo Moura
authors.initials: VM
authors.lastname: Neto
authors.forename: Raquel Ciuvalschi
authors.initials: RC
authors.lastname: Maia
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000096:biosynthesis*; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D005910:Glioma / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000096:biosynthesis*; D009367:Neoplasm Staging; D055815:Young Adult
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D027425:ATP-Binding Cassette, Sub-Family C Proteins; C421109:multidrug resistance-associated protein 1