[Clinical and prognostic analysis of nasopharyngeal carcinoma in 44 children and adolescents].
OBJECTIVE
To evaluate the clinical effect and prognostic factors of nasopharyngeal carcinoma in 44 children and adolescents.


METHODS
From June 1987 to December 2003,44 children and adolescents with nasopharyngeal carcinoma were treated by radiotherapy, and some patients also received chemotherapy. Kaplan-Meier method was used for the survival rate and univariate analysis, and Cox proportional hazard model was used in multivariate analysis.


RESULTS
The 3.5 year survival rate was 84.2% and 62.3%.In the univariate analysis, clinical stage, lymph node (N) stage, radiotherapy dose and chemotherapy were significant prognostic factors of survival.In the multivariate analysis, N stage and chemotherapy were the prognostic factors in the survival rate.


CONCLUSIONS
Most nasopharyngeal carcinomas belong to the advanced degree. These patients are sensitive to radiotherapy and chemotherapy. Combined modality therapy can improve the clinical effect of nasopharyngeal carcinoma in children and adolescents.
Hong
Ji-dong
JD
Department of Oncology, Xiangya Hospital, Central South University, Changsha 41008, China. hongjidong1966@126.com
Liao
Yu-ping
YP
Yuan
Jun
J
Wei
Rei
R
Wang
Xue-wei
XW
Mao
Hai-jiao
HJ
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy*; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D011379:Prognosis; D016019:Survival Analysis