Novel oxidized derivatives of antifungal pyrrolnitrin from the bacterium Burkholderia cepacia K87.
The screening of antifungal active compounds from the fermentation extracts of soil-borne bacterium Burkholderia cepacia K87 afforded pyrrolnitrin (1) and two new pyrrolnitrin analogs, 3-chloro-4-(3-chloro-2-nitrophenyl)-5-methoxy-3-pyrrolin-2-one (2) and 4-chloro-3-(3-chloro-2-nitrophenyl)-5-methoxy-3-pyrrolin-2-one (3). Pyrrolnitrin showed strong antifungal activity against Rhizoctonia solani but the analogs (2 and 3) were found to be marginally active. The isolates, 2 and 3, are believed to be biodegraded derivatives of pyrrolnitrin.
Sultan
Zakir
Z
Department of Chemistry, Kongju National University, Kongju, Korea.
Park
Kyungseok
K
Lee
Sang Yeob
SY
Park
Jung Kon
JK
Varughese
Titto
T
Moon
Surk-Sik
SS
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D016956:Burkholderia cepacia / Q000737:chemistry* / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011764:Pyrrolnitrin / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D012232:Rhizoctonia / Q000187:drug effects; D012988:Soil Microbiology
D000935:Antifungal Agents; D011764:Pyrrolnitrin