A retrospective epidemiological study of clinical signs and familial predisposition associated with aseptic meningitis in the Norwegian population of Nova Scotia duck tolling retrievers born 1994-2003.
Aseptic meningitis (AM) is a disease that causes grave clinical signs such as intensive neck pain, fever, and lethargy. The severity of this disease is reflected in the fact that affected animals require long-term, and in chronic cases, lifelong therapy with corticosteroids. A number of dogs must be euthanized because of therapeutic failure. In recent years, the Norwegian population of Nova Scotia duck tolling retrievers has experienced an increase in individuals with AM. The aim of the present study was to investigate the prevalence of AM and to pursue the suspicion of hereditary factors influencing an accumulation of AM cases in the breed. Using the Norwegian Kennel Club registery, a random sample (362 dogs) stratified by year of birth was drawn from the total population born from 1994 to 2003 (1525 individuals). The owners were contacted and questioned about clinical signs of AM in their dogs. Subsequently, the practising veterinarians and the breeders of positive responders were contacted in order to confirm a clinical diagnosis of AM and to identify possible affected family members. Pedigrees of AM positive individuals and affected relatives were investigated. The study estimated a prevalence of AM of 2.5%. For all affected dogs, it was possible to trace the pedigree of both parents of affected dogs back to a specific founder dog. The genealogical investigation strongly indicates that genetic factors are involved in the etiology of the disease.
Anfinsen
Kristin P
KP
Department of Companion Animal Clinical Sciences, Norwegian School of Veterinary Science, Postboks 8146 Dep, 0033 Oslo, Norway.
Berendt
Mette
M
Liste
Flora J H
FJ
Haagensen
Therese R
TR
Indrebo
Astrid
A
Lingaas
Frode
F
Stigen
Oyvind
O
Alban
Lis
L
D000818:Animals; D004198:Disease Susceptibility / Q000662:veterinary; D004283:Dog Diseases / Q000453:epidemiology* / Q000235:genetics*; D004285:Dogs; D005260:Female; D020022:Genetic Predisposition to Disease; D008297:Male; D008582:Meningitis, Aseptic / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary*; D009664:Norway / Q000453:epidemiology; D010375:Pedigree; D015995:Prevalence; D012189:Retrospective Studies
J Vet Intern Med. 1988 Jan-Mar;2(1):26-35
3065492
J Am Vet Med Assoc. 1991 Mar 1;198(5):849-56
2026537
Vet Res Commun. 2003 Sep;27 Suppl 1:763-5
14535516
Nihon Juigaku Zasshi. 1990 Feb;52(1):55-61
2313952
J Neuroimmunol. 1998 Aug 14;89(1-2):182-90
9726841
J Comp Pathol. 1987 Mar;97(2):121-8
2885350
J Vet Intern Med. 1995 Sep-Oct;9(5):304-14
8531175
J Am Vet Med Assoc. 1989 Jun 1;194(11):1595-7
2753780
Vet Pathol. 1995 Jul;32(4):337-45
7483207
J Am Vet Med Assoc. 1992 Nov 15;201(10):1553-8
1363239
Tierarztl Prax. 1996 Oct;24(5):514-8
8999602
Res Vet Sci. 1995 Mar;58(2):103-8
7761686
Vet Pathol. 1981 Mar;18(2):219-23
7467081
Vet Rec. 1993 Apr 3;132(14):361-2
8488643
J Vet Intern Med. 2002 May-Jun;16(3):262-8
12041655
Zentralbl Veterinarmed A. 1999 Mar;46(2):75-85
10216444
Vet Rec. 1978 Jun 17;102(24):519-22
675999
Toxicol Pathol. 1989;17(1 Pt 2):129-37
2568680
J Small Anim Pract. 2000 Jul;41(7):295-301
10976624
Vet Rec. 1973 Apr 7;92(14):363-6
4146411