Synthesis and antiviral evaluation of 7-fluoro-7-deaza-2-aminopurine nucleoside derivatives.
Three 7-fluoro-7-deaza-2-aminopurine nucleoside derivatives were synthesized and evaluated as potential inhibitors of RNA virus replication, including hepatitis C virus (HCV).
Leroy
Frederic
F
Idenix Pharmaceuticals, Medicinal Chemistry Laboratory, Cap Gamma, 1682 Rue de la Valsière, 34189 Montpellier Cedex 4, France. Leroy.frederic@idenix.com
Chaves
Dominique
D
Dukhan
David
D
Storer
Richard
R
Sommadossi
Jean-Pierre
JP
Loi
Anna Giulia
AG
Cadeddu
Alessandra
A
Fanti
Maura
M
Boscu
Nadia
N
Bassetti
Fabiola
F
Liuzzi
Michel
M
Gosselin
Gilles
G
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D016174:Hepacivirus / Q000187:drug effects; D011684:Purine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000998:Antiviral Agents; D011684:Purine Nucleosides