Risk factors for posterior cystoid retinal degeneration in central serous chorioretinopathy.
OBJECTIVE
To identify factors associated with the development of posterior cystoid retinal degeneration (PCRD) in central serous chorioretinopathy (CSC).


METHODS
The authors retrospectively studied 51 eyes of 51 patients with chronic CSC and subretinal or intraretinal exudation documented by optical coherence tomography (OCT), and evaluated the association of hypertension, systemic use of corticosteroids, duration of symptoms, subretinal fibrosis, and large laser scars with the development of PCRD.


RESULTS
Twenty-four eyes (47%) had PCRD and 27 eyes (53%) had serous macular detachment without cystoid retinal changes. Multivariate analysis showed that a duration of symptoms exceeding 5 years (odds ratio [OR], 25.4; 95% confidence interval [CI], 2.8-233.2; P = 0.004) and subretinal fibrosis (OR, 19.1; 95% CI, 1.8-205.1; P = 0.015) were significantly associated with PCRD.


CONCLUSIONS
Disease duration longer than 5 years and subretinal fibrosis are associated with the development of PCRD in CSC. Prospective evaluations could substantiate the associations found in this study and further clarify their significance.
Piccolino
Felice Cardillo
FC
Fondazione per la Macula Onlus, Genova. felice.cardillopiccolino@unito.it
De La Longrais
Roberta Rigault
RR
Manea
Marilisa
M
Cicinelli
Simonetta
S
Ravera
Giambattista
G
D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D015862:Choroid Diseases / Q000150:complications*; D002921:Cicatrix / Q000150:complications / Q000209:etiology; D003560:Cysts / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D005355:Fibrosis; D006801:Humans; D053685:Laser Therapy / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D012160:Retina / Q000473:pathology; D012162:Retinal Degeneration / Q000175:diagnosis / Q000209:etiology*; D012164:Retinal Diseases / Q000150:complications*; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D041623:Tomography, Optical Coherence
D000305:Adrenal Cortex Hormones