Serum homocysteine in pre-eclampsia and eclampsia.
Pre-eclampsia and eclampsia are common obstetrical problem causing adverse effects on pregnancy outcome. Large bodies of evidences suggest that hyperhomocysteinemia is a causal factor of pre-eclampsia/eclampsia. This study designed to explore the association between hyperhomocysteinemia and pre-eclampsia/eclampsia, the knowledge of which expected to be used for prevention of pre-eclampsia and eclampsia. In a case-control study serum homocysteine was measured in 136 controls (healthy pregnant), 84 pre-eclamptic and 120 eclamptic pregnant women. Serum homocysteine in patients with pre-eclampsia (9.54 +/- 3.21 micromol/L) and eclampsia (10.57 +/- 3.39 micromol/L) found to be significantly increased compared to controls (6.86 +/- 2.47 micromol/L) (p < 0.001). Between pre-eclampsia and eclampsia, homocysteine found to be raised more in eclampsia compared to pre-eclampsia (p < 0.03). In conclusion, hyperhomocysteinemia is associated with pre-eclampsia as well as eclampsia, but in eclampsia the severity of homocysteine elevation is more compared to that in pre-eclampsia.
Hoque
Md Mozammel
MM
Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh. m_mhoque@yahoo.com
Bulbul
Tania
T
Mahal
Monzarin
M
Islam
Nur-A-Farzana
NA
Ferdausi
Munira
M
D000328:Adult; D001459:Bangladesh; D016022:Case-Control Studies; D004461:Eclampsia / Q000097:blood / Q000503:physiopathology*; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood / Q000503:physiopathology*; D010865:Pilot Projects; D011225:Pre-Eclampsia / Q000097:blood / Q000503:physiopathology*; D011247:Pregnancy; D012307:Risk Factors
D006710:Homocysteine