title: Effects of thrombosed vena cava filters on blood flow: flow visualization and numerical modeling.
abstract: Inferior vena cava (IVC) filters are used to prevent pulmonary embolism (PE) in patients with deep vein thrombosis for whom anticoagulation is contraindicated. IVC filters have been shown to be effective in trapping embolized clots and preventing PE; however, among the commercially available designs, the optimal balance of clot capture efficiency, clot dissolution, and prevention of to vena cava occlusion is unknown. Clot capture efficiency has been quantified in numerous in vitro studies, in which model clots are released into a mock circulation system, with the relative capture efficiency of various IVC filters analyzed statistically. In general, two-stage filters have been found to be more efficient than one-stage filters. However, other factors may play a role in the ultimate dissolution of clots and in the overall effect of the resulting blood flow on caval vasculature. Clot dissolution has been shown to increase with increasing wall shear stress, while low and oscillating wall shear stresses are known to have a deleterious effect on vessel walls, causing intimal hyperplasia. This paper describes the effect of IVC filters on blood flow, velocity patterns, and wall shear stress by flow visualization and computational fluid dynamics.
authors.affiliation: Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, White Oak Bldg 62, Rm 2210, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA. sandy.stewart@fda.hhs.gov
authors.forename: Sandy F C
authors.initials: SF
authors.lastname: Stewart
authors.forename: Ronald A
authors.initials: RA
authors.lastname: Robinson
authors.forename: Robert A
authors.initials: RA
authors.lastname: Nelson
authors.forename: Richard A
authors.initials: RA
authors.lastname: Malinauskas
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular; D013927:Thrombosis / Q000503:physiopathology*; D016306:Vena Cava Filters