title: Nucleoside phosphonic acids in thymidine phosphorylase inhibition: structure-activity relationship.
abstract: A number of structurally diverse nucleoside phosphonic acids have been tested against human recombinant thymidine phosphorylase and human platelets supernatant using 2'-deoxy-5-nitrouridine as the substrate. We have selected several inhibitors working at micromolar level as lead structures for further evaluation.
authors.affiliation: Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo n. 2, 166 10 Prague 6, Czech Republic.
authors.forename: Natalya
authors.initials: N
authors.lastname: Panova
authors.forename: Ivana
authors.initials: I
authors.lastname: Kosiová
authors.forename: Magdalena
authors.initials: M
authors.lastname: Petrová
authors.forename: Václav
authors.initials: V
authors.lastname: Vanĕk
authors.forename: Radek
authors.initials: R
authors.lastname: Liboska
authors.forename: Sona
authors.initials: S
authors.lastname: Kovacková
authors.forename: Petr
authors.initials: P
authors.lastname: Kocalka
authors.forename: Sárka
authors.initials: S
authors.lastname: Králíková
authors.forename: Zdenĕk
authors.initials: Z
authors.lastname: Tocík
authors.forename: Ondrej
authors.initials: O
authors.lastname: Páv
authors.forename: Ondrej
authors.initials: O
authors.lastname: Paces
authors.forename: Dominik
authors.initials: D
authors.lastname: Rejman
authors.forename: Ivan
authors.initials: I
authors.lastname: Rosenberg
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000201:enzymology; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D009705:Nucleosides / Q000737:chemistry* / Q000494:pharmacology*; D063065:Organophosphonates / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013939:Thymidine Phosphorylase / Q000037:antagonists & inhibitors* / Q000737:chemistry
chemical_list: D004791:Enzyme Inhibitors; D009705:Nucleosides; D063065:Organophosphonates; D013939:Thymidine Phosphorylase