Selective cytotoxic Ru(II) arene Cp* complex salts [R-PhRuCp*](+)X(-) for X = BF4(-), PF6(-), and BPh4(-).
A novel series of ionic Ru(II) arene Cp* sandwich complexes has been synthesized and characterized. Screening results for cytotoxicity against a range of human tumor cell lines and normal human cells indicate that the complexes show promising anticancer activity, which varies with changes in the arene ligand and the anionic counterion.
Loughrey
Bradley T
BT
Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Australia.
Healy
Peter C
PC
Parsons
Peter G
PG
Williams
Michael L
ML
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity*; D012428:Ruthenium / Q000737:chemistry*; D012492:Salts / Q000737:chemistry*
D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D012492:Salts; D012428:Ruthenium