Long-chain omega-3 polyunsaturated fatty acids in the blood of children and adolescents with juvenile bipolar disorder.
Reduced long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been reported in adult patients suffering from depression and bipolar disorder (BD). LCn-3PUFA status has not previously been examined in children and adolescents with BD compared with healthy controls. Fifteen children and adolescents (9-18 years, M +/- SD = 14.4 +/- 3.48) diagnosed with juvenile bipolar disorder (JBD) and fifteen healthy age and sex-matched controls were assessed for dietary intake and fasting red blood cell (RBC) membrane concentrations of LCn-3PUFA. Fatty acid concentrations were compared between participants diagnosed with JBD and controls after controlling for dietary intake. RBC membrane concentrations of EPA and DHA were not significantly lower in participants diagnosed with JBD compared with healthy controls (M +/- sem EPA = 3.37 +/- 0.26 vs. 3.69 +/- 0.27 microg/mL, P = 0.458; M +/- sem DHA = 22.08 +/- 2.23 vs. 24.61 +/- 2.38 microg/mL, P = 0.528) after controlling for intake. Red blood cell DHA was negatively (r = -0.55; P = 0.044) related to clinician ratings of depression. Although lower RBC concentrations of LCn-3PUFA were explained by lower intakes in the current study, previous evidence has linked reduced LCn-3PUFA to the aetiology of BD. As RBC DHA was also negatively related to symptoms of depression, a randomised placebo-controlled study examining supplementation with LCn-3PUFA as an adjunct to standard pharmacotherapy appears warranted in this patient population.
Clayton
Edward H
EH
NSW Department of Primary Industries, Wagga Wagga Agricultural Institute, Pine Gully Rd, Wagga Wagga, NSW, 2650, Australia. edward.clayton@dpi.nsw.gov.au
Hanstock
Tanya L
TL
Hirneth
Stephen J
SJ
Kable
Colin J
CJ
Garg
Manohar L
ML
Hazell
Philip L
PL
D000293:Adolescent; D001714:Bipolar Disorder / Q000097:blood*; D002648:Child; D004281:Docosahexaenoic Acids / Q000097:blood; D015118:Eicosapentaenoic Acid / Q000097:blood; D004912:Erythrocytes / Q000737:chemistry; D015525:Fatty Acids, Omega-3 / Q000097:blood*; D006801:Humans
D015525:Fatty Acids, Omega-3; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid
Neurochem Res. 1999 Mar;24(3):399-406
10215514
Bipolar Disord. 2001 Aug;3(4):202-10
11552959
Psychiatry Res. 1999 Mar 22;85(3):275-91
10333380
Lancet. 1998 Apr 18;351(9110):1213
9643729
J Clin Psychiatry. 2005 Jun;66(6):726-9
15960565
Neurosci Lett. 1996 Dec 20;220(3):171-4
8994220
Acta Psychiatr Scand. 2000 Sep;102(3):162-70
11008850
Pharmacol Res. 2007 Mar;55(3):217-23
17324586
JAMA. 1997 Mar 19;277(11):925-6
9062334
J Affect Disord. 2003 Nov;77(2):179-90
14607396
Psychiatry Res. 1997 Dec 5;73(3):159-71
9481807
J Lipid Res. 2006 Jan;47(1):172-80
16210728
Br J Psychiatry. 2006 Aug;189:109-17
16880479
J Affect Disord. 1994 Aug;31(4):281-94
7989643
J Am Acad Child Adolesc Psychiatry. 1995 Apr;34(4):454-63
7751259
J Affect Disord. 1998 Mar;48(2-3):149-55
9543204
J Clin Invest. 1996 Feb 15;97(4):1129-33
8613538
J Neurochem. 2001 May;77(3):796-803
11331408
J Lipid Res. 1986 Jan;27(1):114-20
3958609
Am J Clin Nutr. 2007 Nov;86(5):1278-85
17991636
J Affect Disord. 1996 Apr 26;38(1):35-46
8735157
Br J Psychiatry. 1978 Nov;133:429-35
728692
Br J Psychiatry. 2006 Jan;188:46-50
16388069
Nutr J. 2008 Feb 14;7:8
18275609
Biol Psychiatry. 1998 Mar 1;43(5):315-9
9513745
Int J Epidemiol. 2001 Apr;30(2):334-40
11369739
J Psychiatr Res. 2003 Jan-Feb;37(1):61-73
12482471
Prev Med. 2006 Jan;42(1):4-13
16337677
J Am Acad Child Adolesc Psychiatry. 1997 Sep;36(9):1168-76
9291717
J Clin Psychiatry. 2007 Jul;68(7):1056-61
17685742
J Neurol Neurosurg Psychiatry. 1960 Feb;23:56-62
14399272
Eur J Clin Nutr. 2005 Jul;59(7):817-25
15900310
Am J Clin Nutr. 1993 May;57(5 Suppl):801S-805S; discussion 805S-806
8475898
Neurochem Int. 1981 Mar;3(1):37-42
20487806
J Anim Sci. 1998 Apr;76(4):1216-31
9581947
Eur J Clin Nutr. 2004 May;58(5):761-70
15116079
Eur Neuropsychopharmacol. 2003 Mar;13(2):99-103
12650953
Arch Gen Psychiatry. 1983 Nov;40(11):1228-31
6639293
Bipolar Disord. 2000 Sep;2(3 Pt 2):281-93
11249806
BMJ. 1996 Feb 3;312(7026):287-92
8611787
Biol Psychiatry. 2004 Oct 1;56(7):490-6
15450784
J Chromatogr A. 1997 Aug 22;778(1-2):435-9
9299750
Lipids Health Dis. 2007 Sep 18;6:21
17877810
Acta Neuropsychiatr. 2007 Apr;19(2):92-103
26952820
Acta Psychiatr Scand Suppl. 1994;377:7-10
8053370
Am J Clin Nutr. 1991 Oct;54(4):668-73
1832813
Eur J Clin Nutr. 2007 Nov;61(11):1312-7
17299483
Med Hypotheses. 2007;68(3):515-24
17045757
Am J Psychiatry. 2003 Dec;160(12):2222-7
14638594
Prostaglandins Leukot Essent Fatty Acids. 1999 Apr;60(4):217-34
10397403
J Am Acad Child Adolesc Psychiatry. 2001 Apr;40(4):450-5
11314571