title: Water intoxication induced by low-dose oral cyclophosphamide in a patient with anti-neutrophil cytoplasmic antibody-related glomerulonephritis.
abstract: We reported the case of a 70-year-old woman with moderate renal failure due to anti-neutrophil cytoplasmic antibody-related glomerulonephritis who developed symptomatic water intoxication (serum Na: 108 mEq/L) following treatment with oral low-dose cyclophosphamide (CY) (50mg/day). Estimated glomerular filtration rate was 29.5 mL/min/1.73 m(2). She had drunk >2 L of fluid in 12 h prior to the development of cerebral oedema. This rare case suggests that oral low-dose CY could be an occult cause of water intoxication in patients with chronic kidney disease taking large fluid volumes.
authors.affiliation: Division of Blood Purification , Hamamatsu University School of Medicine.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kato
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sugiura
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Taro
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authors.lastname: Misaki
authors.forename: Takayuki
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authors.lastname: Yasuda
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Fujigaki
authors.forename: Akira
authors.initials: A
authors.lastname: Hishida
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