Enhanced activity of fluorinated quaternary ammonium surfactants against Pseudomonas aeruginosa.
A novel series of fluorinated quaternary bisammonium surfactants has been synthesized in view to optimize their antimicrobial activities against Pseudomonas aeruginosa. As compared with commercial references, most of the new surfactants synthesized exhibit an enhanced activity which is discussed as a function of the nature of the spacer group between the quaternized nitrogen atoms and of the nature of the connector function between the nitrogen atoms and the perfluorinated carbon chains. It appears that the fluorinated "Gemini" surfactants bearing an amide connector can be an interesting alternative to hydrocarbon ammonium salts as preservatives and disinfectants against P. aeruginosa.
Massi
Lionel
L
Institut de Chimie de Nice FR 3037 CNRS, Laboratoire de Chimie des Matériaux Organiques et Métalliques, CMOM, UFR Sciences, Université de Nice-Sophia Antipolis, Parc Valrose, 06108 Nice Cedex 2, France. Lionel.Massi@unice.fr
Guittard
Frederic
F
Levy
Richard
R
Géribaldi
S
S
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002117:Calcitriol / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D054879:Halogenation; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D000644:Quaternary Ammonium Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D012015:Reference Standards; D013501:Surface-Active Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
C411462:1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3); D000900:Anti-Bacterial Agents; D000644:Quaternary Ammonium Compounds; D013501:Surface-Active Agents; D002117:Calcitriol