title: DNA and RNA quadruplex ligands.
abstract: Guanine-rich nucleic acids can adopt unusual structures called guanine quadruplexes (G4) based on stacked guanine quartets. Both RNA and DNA backbones are compatible with G4 formation. As RNA and DNA quadruplexes may be recognized by ligands, it is important to understand the rules that govern the stability and specificity of these complexes. We explore the binding of a pyridine dicarboxamide derivative to various oligoribo- and oligodeoxyribo-nucleotides.
authors.affiliation: Muséum national d'Histoire naturelle USM 503, INSERM U565, CNRS UMR5153, Paris, France.
authors.forename: Anne
authors.initials: A
authors.lastname: De Cian
authors.forename: Julien
authors.initials: J
authors.lastname: Gros
authors.forename: Aurore
authors.initials: A
authors.lastname: Guédin
authors.forename: Meriem
authors.initials: M
authors.lastname: Haddi
authors.forename: Sébastien
authors.initials: S
authors.lastname: Lyonnais
authors.forename: Lionel
authors.initials: L
authors.lastname: Guittat
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Riou
authors.forename: Chantal
authors.initials: C
authors.lastname: Trentesaux
authors.forename: Barbara
authors.initials: B
authors.lastname: Saccà
authors.forename: Laurent
authors.initials: L
authors.lastname: Lacroix
authors.forename: Patrizia
authors.initials: P
authors.lastname: Alberti
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Mergny
mesh_terms: D000818:Animals; D004247:DNA / Q000737:chemistry*; D054856:G-Quadruplexes; D006801:Humans; D008024:Ligands; D011725:Pyridines / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*; D016615:Telomere / Q000737:chemistry
chemical_list: C502660:2,6-N,N'-methyl-quinolinio-3-yl-pyridine dicarboxamide; D008024:Ligands; D011725:Pyridines; D011804:Quinolines; D012313:RNA; D004247:DNA