Preparation of mannosylated oligoribonucleotides.
Multivalent mannosides were synthesized for attachment to oligoribonucleotides via 3,4-diethoxy-3-cyclobutene-1,2-dione (squarate). The conjugates have potential to be used in receptor-mediated endocytosis of small interference RNAs into dendritic cells through interactions with mannose-binding lectins.
Zhao
Yuyan
Y
Department of Chemistry, Brock University, St. Catharines, ON, L2S 3A1, Canada.
Yan
Hongbin Tony
HT
D008362:Mannosides / Q000138:chemical synthesis / Q000737:chemistry*; D009843:Oligoribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D034741:RNA, Small Interfering / Q000737:chemistry
D008362:Mannosides; D009843:Oligoribonucleotides; D034741:RNA, Small Interfering