Pathological and phylogenetic features of prevalent canine distemper viruses in wild masked palm civets in Japan.
Ten wild masked palm civets infected with canine distemper virus (CDV), captured in Japan from 2005 to 2007, were histopathologically and phylogenetically analyzed. Phylogenetic analysis based on the amino acid sequences of the H protein of two CDV isolates from masked palm civets revealed that the two isolates were classified into the clade of recent isolates in Japan. Histopathologically marked lesions of virus encephalitis were present in the brain, whereas gastrointestinal lesions were absent or at a mild degree. The distribution of the lesions resembles that of recent CDV cases in dogs. Therefore, recent CDV infections in masked palm civets could be caused by recently prevalent CDV in dogs. The possibility of the masked palm civet as a spreader of CDV among wildlife is also discussed.
Takayama
Ikuyo
I
Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.
Kubo
Masahito
M
Takenaka
Akiko
A
Fujita
Kentaro
K
Sugiyama
Takaaki
T
Arai
Tetsuro
T
Yoneda
Misako
M
Sato
Hiroki
H
Yanai
Tokuma
T
Kai
Chieko
C
D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000473:pathology / Q000821:virology; D004216:Distemper / Q000150:complications / Q000453:epidemiology* / Q000473:pathology*; D004217:Distemper Virus, Canine / Q000235:genetics* / Q000302:isolation & purification; D018792:Encephalitis, Viral / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D005260:Female; D041981:Gastrointestinal Tract / Q000473:pathology / Q000821:virology; D005814:Genes, Viral; D007564:Japan / Q000453:epidemiology; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D015995:Prevalence; D020539:Sequence Analysis, Protein; D045949:Viverridae / Q000821:virology*