Acute ophthalmoparesis accompanied with Influenza A infection.
We report the first adult case of Influenza A virus infection with acute unilateral oculomotor nerve palsy. Unlike previous reports, our patient showed isolated unilateral oculomotor nerve palsy as soon as she developed general symptoms with Influenza A infection, and demonstrated no significant increases of anti-ganglioside antibodies including anti-GQ1b IgG antibody. She recovered immediately after treatment of oseltamivir phosphate. As for the mechanism by which Influenza A infection caused ophthalmoparesis, small vessel vasculitis due to direct invasion of the virus was speculated. Although influenza encephalitis/encephalopathy including acute necrotizing encephalopathy are most frequently reported in children, it is noteworthy that influenza virus can also cause focal neurological signs such as ophthalmoparesis in adult cases.
Yamashita
Satoshi
S
Department of Neurology, Kumamoto Medical Center, National Hospital Organization, Graduate School of Medical Sciences, Kumamoto University, Kumamoto. y-stsh@pg8.so-net.ne.jp
Kouzaki
Yanosuke
Y
Kawano
Ryoko
R
Tokunaga
Makoto
M
Uchino
Makoto
M
D000328:Adult; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification; D007251:Influenza, Human / Q000150:complications* / Q000188:drug therapy; D009886:Ophthalmoplegia / Q000150:complications*; D053139:Oseltamivir / Q000627:therapeutic use
D053139:Oseltamivir