Synthesis of 3'- and 6'-functionalized locked nucleic acid (LNA) analogues.
Two locked nucleic acid (LNA) analogues, i.e. a 3'-C-hydroxymethyl derivative and a 6'(R)-hydroxymethyl derivative of the LNA thymidine monomer, have been synthesized efficiently using convergent strategies. The hydroxymethyl group at the 3'-position or the 6'-position provides a versatile starting point for various modifications of LNA.
Sharma
Pawan K
PK
Department of Chemistry, Kurukshetra University, Kurukshetra-136 119, India. talk2pawan@gmail.com
Enderlin
Gerald
G
Kumar
Surender
S
Nielsen
Poul
P
D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D013936:Thymidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
D009841:Oligonucleotides; C477371:locked nucleic acid; D013936:Thymidine