Synthesis of new non-nucleosidic ligand building blocks for solid-phase oligonucleotide assembly.
Synthesis of new non-nucleosidic building blocks that incorporate 2,2'-biquinoline is described. Starting from readily available bicinchoninic acid, the corresponding bifunctional monomeric reagents for solid-phase oligonucleotide synthesis, phosphoramidite and H-phosphonate, have been prepared. The compounds developed may be useful for the design of sequence-specific artificial nucleases.
Jamil
Adnan
A
Division of Chemical Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK.
Zubin
Evgeny M
EM
Stetsenko
Dmitry A
DA
D007202:Indicators and Reagents; D008024:Ligands; D009841:Oligonucleotides / Q000138:chemical synthesis*; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D012260:Ribonucleases / Q000737:chemistry
D007202:Indicators and Reagents; D008024:Ligands; D009841:Oligonucleotides; D011804:Quinolines; D012260:Ribonucleases