title: Limbic and cortical information processing in the nucleus accumbens.
abstract: The nucleus accumbens regulates goal-directed behaviors by integrating information from limbic structures and the prefrontal cortex. Here, we review recent studies in an attempt to provide an integrated view of the control of information processing in the nucleus accumbens in terms of the regulation of goal-directed behaviors and how disruption of these functions might underlie the pathological states in drug addiction and other psychiatric disorders. We propose a model that could account for the results of several studies investigating limbic-system interactions in the nucleus accumbens and their modulation by dopamine and provide testable hypotheses for how these might relate to the pathophysiology of major psychiatric disorders.
authors.affiliation: Department of Psychiatry, McGill University, Montreal, Quebec, H3A 1A1, Canada. yukiori.goto@mcgill.ca
authors.forename: Yukiori
authors.initials: Y
authors.lastname: Goto
authors.forename: Anthony A
authors.initials: AA
authors.lastname: Grace
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D006801:Humans; D008032:Limbic System / Q000502:physiology*; D008606:Mental Processes / Q000502:physiology*; D008954:Models, Biological; D009434:Neural Pathways / Q000502:physiology; D009714:Nucleus Accumbens / Q000502:physiology*
references.citation: J Neurosci. 2001 Feb 15;21(4):RC131
references.pmid: 11160416
references.citation: Neuroscience. 2005;136(4):1049-71
references.pmid: 16226842
references.citation: Nat Rev Neurosci. 2008 May;9(5):344-56
references.pmid: 18425089
references.citation: Trends Neurosci. 2007 May;30(5):220-7
references.pmid: 17400299
references.citation: Neuroscience. 1988 Jan;24(1):19-28
references.pmid: 3368048
references.citation: J Neurosci. 2008 May 7;28(19):5088-98
references.pmid: 18463262
references.citation: J Neurophysiol. 1989 Apr;61(4):780-98
references.pmid: 2723720
references.citation: J Neurosci. 2001 Jun 15;21(12):4498-504
references.pmid: 11404437
references.citation: J Neurosci. 1994 Jan;14(1):88-106
references.pmid: 7904306
references.citation: Neuron. 2002 Oct 10;36(2):241-63
references.pmid: 12383780
references.citation: Behav Neurosci. 2003 Feb;117(1):150-68
references.pmid: 12619918
references.citation: Cortex. 1993 Jun;29(2):293-304
references.pmid: 8348826
references.citation: J Clin Psychiatry. 2004;65 Suppl 14:11-7
references.pmid: 15554783
references.citation: Neuropsychopharmacology. 2000 Sep;23(3):223-39
references.pmid: 10942847
references.citation: Nat Neurosci. 2004 May;7(5):446-51
references.pmid: 15114356
references.citation: Neuron. 2005 Jul 21;47(2):255-66
references.pmid: 16039567
references.citation: Science. 2001 Jun 29;292(5526):2499-501
references.pmid: 11375482
references.citation: Aust N Z J Psychiatry. 1991 Jun;25(2):277-83
references.pmid: 1652243
references.citation: J Neurosci. 2006 Feb 1;26(5):1579-87
references.pmid: 16452681
references.citation: Neurosci Lett. 1994 Aug 1;176(2):173-7
references.pmid: 7830940
references.citation: Eur J Neurosci. 2005 Sep;22(5):1214-20
references.pmid: 16176364
references.citation: Nat Neurosci. 2001 Dec;4(12):1217-23
references.pmid: 11694884
references.citation: J Comp Neurol. 2005 Nov 28;492(4):442-55
references.pmid: 16228995
references.citation: Ann N Y Acad Sci. 1992 Jul 1;658:111-27
references.pmid: 1497255
references.citation: Neuroscience. 1999 Mar;89(3):637-41
references.pmid: 10199600
references.citation: Eur J Neurosci. 1993 Feb 1;5(2):107-17
references.pmid: 7903183
references.citation: Nat Neurosci. 2005 Jun;8(6):805-12
references.pmid: 15908948
references.citation: Neuroscience. 1998 Oct;86(3):1001-9
references.pmid: 9692735
references.citation: Annu Rev Neurosci. 1979;2:447-65
references.pmid: 44174
references.citation: Neuron. 2006 Apr 6;50(1):13-8
references.pmid: 16600851
references.citation: Annu Rev Neurosci. 2000;23:185-215
references.pmid: 10845063
references.citation: Neuroscience. 1998 Mar;83(1):169-76
references.pmid: 9466407
references.citation: Ann N Y Acad Sci. 1999 Jun 29;877:49-63
references.pmid: 10415642
references.citation: Mol Cell Biochem. 1982 Mar 19;43(2):65-80
references.pmid: 6123940
references.citation: Psychopharmacology (Berl). 2007 Apr;191(3):587-98
references.pmid: 16972104
references.citation: Annu Rev Neurosci. 2006;29:565-98
references.pmid: 16776597
references.citation: Cereb Cortex. 2007 Sep;17 Suppl 1:i171-81
references.pmid: 17726000
references.citation: Behav Brain Res. 2005 May 28;160(2):222-35
references.pmid: 15863219
references.citation: Brain Res Bull. 2001 May 1;55(1):71-7
references.pmid: 11427340
references.citation: Science. 2005 Nov 25;310(5752):1340-3
references.pmid: 16311338
references.citation: Nat Neurosci. 1998 Aug;1(4):318-23
references.pmid: 10195166
references.citation: Behav Brain Res. 1991 Dec 13;46(1):17-29
references.pmid: 1786111
references.citation: Behav Brain Res. 2002 Dec 2;137(1-2):149-63
references.pmid: 12445721
references.citation: Biol Psychiatry. 1999 Jul 1;46(1):56-72
references.pmid: 10394474
references.citation: Brain Res Brain Res Rev. 2000 Mar;31(2-3):330-41
references.pmid: 10719160
references.citation: J Neurosci. 1998 Jul 1;18(13):5095-102
references.pmid: 9634575
references.citation: Schizophr Res. 2007 Jan;89(1-3):339-49
references.pmid: 17055703
references.citation: J Comp Neurol. 1986 Sep 1;251(1):84-99
references.pmid: 3760260
references.citation: J Neurosci. 2002 Oct 15;22(20):9070-7
references.pmid: 12388614
references.citation: Psychopharmacology (Berl). 2004 Jun;174(1):151-62
references.pmid: 15205886
references.citation: J Comp Neurol. 2002 Apr 29;446(2):151-65
references.pmid: 11932933
references.citation: J Neurosci. 1997 Mar 15;17(6):2143-67
references.pmid: 9045740
references.citation: Ann N Y Acad Sci. 1999 Jun 29;877:140-56
references.pmid: 10415648
references.citation: J Neurosci. 1995 May;15(5 Pt 1):3622-39
references.pmid: 7751934
references.citation: Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4147-52
references.pmid: 17360491
references.citation: J Neurosci. 2007 Oct 17;27(42):11424-30
references.pmid: 17942737
references.citation: Trends Cogn Sci. 2001 Aug 1;5(8):321-323
references.pmid: 11476991
references.citation: J Neurosci. 2008 Jun 18;28(25):6372-82
references.pmid: 18562607
references.citation: Epilepsia. 2000 Dec;41(12):1626-32
references.pmid: 11114222