Design and synthesis of novel oxindoles as potential non-nucleosidic reverse transcriptase inhibitors against HIV.
We describe here the synthesis of novel oxindoles by cycloproponation of its diazo derivatives. The synthesis involves the use of allyl methyl sulfide and allyl alcohol as olefins and rhodium acetate as catalyst. These oxindoles have been designed to act as non-nucleosidic reverse transcriptase inhibitors (NNRTIs) against HIV.
Kumari
Garima
G
Nucleic Acids Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad-211002, India.
Singh
Ramendra K
RK
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry; D015195:Drug Design; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D000078183:Oxindoles; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry
D019380:Anti-HIV Agents; D007211:Indoles; D000078183:Oxindoles; D018894:Reverse Transcriptase Inhibitors; C022960:2-oxindole