Chloroquine mediated molecular tuning of astrocytes for enhanced permissiveness to HIV infection.
We report in this study that minimum productive HIV infection in astrocytes (a predominant cell type in brain and persists for the entire life) occurs through endocytosis. The lysosomotropic agent chloroquine enhanced permissiveness of astrocytes to HIV infection possibly by circumventing degradation of endosome-entrapped viral particles. In particular, chloroquine may promote establishment of a stable long term viral reservoir in astrocytes and may eventually facilitate early onset of neurological complications.
Vijaykumar
Theophilus S
TS
Department of Neurology, Johns Hopkins University (JHU), Baltimore, MD, USA.
Nath
Avindra
A
Chauhan
Ashok
A
D018501:Antirheumatic Agents / Q000494:pharmacology*; D001253:Astrocytes / Q000187:drug effects* / Q000821:virology*; D001921:Brain / Q000166:cytology; D002478:Cells, Cultured; D002738:Chloroquine / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006678:HIV / Q000502:physiology*; D015658:HIV Infections / Q000473:pathology*; D006801:Humans; D019169:Jurkat Cells; D018942:Macrolides / Q000494:pharmacology
D018501:Antirheumatic Agents; D004791:Enzyme Inhibitors; D018942:Macrolides; C057620:bafilomycin A; D002738:Chloroquine
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