title: Multicentric transitional cell carcinoma of the vagina and the ureter.
abstract: Primary transitional cell carcinoma (TCC) of the vagina represents an extremely rare neoplasm and is associated with multicentric TCC of the urinary tract in all described cases. A case of multicentric TCC of the vagina and the left ureter in a 73-year-old woman is reported. Immunohistochemical analysis of cytokeratin expression was performed. Immunohistochemistry proved to play an important role in the differential diagnosis of vaginal TCC, supported the morphological diagnosis of TCC, and largely excluded the diagnosis of vaginal papillary carcinoma with transitional features as a morphological variant of squamous cell carcinoma. Subsequent urological examination revealed multicentric TCC of the left ureter. During the follow up, the metastases of the vaginal TCC into the regional inguinal lymph nodes were diagnosed, suggesting that indolent clinical course is not a rule in this type of tumor.
authors.affiliation: Department of Pathology, Masaryk University and University Hospital, 625 00 Brno, Czech Republic. marherman@post.cz
authors.forename: Marketa
authors.initials: M
authors.lastname: Hermanova
authors.forename: Vit
authors.initials: V
authors.lastname: Vitezslav
authors.forename: Richard
authors.initials: R
authors.lastname: Husicka
authors.forename: Renata
authors.initials: R
authors.lastname: Neumanova
authors.forename: Dalibor
authors.initials: D
authors.lastname: Pacik
mesh_terms: D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000737:chemistry / Q000556:secondary* / Q000628:therapy; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D009378:Neoplasms, Multiple Primary; D010166:Palliative Care; D014516:Ureteral Neoplasms / Q000737:chemistry / Q000473:pathology*; D014625:Vaginal Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy