title: Pellucid marginal degeneration and bilateral corneal perforation: case report and review of the literature.
abstract: OBJECTIVE
  To review corneal perforation cases in pellucid marginal degeneration and report a case of bilateral spontaneous perforation at presentation in rigid gas permeable contact lens wear and pellucid marginal degeneration.
  
  
  METHODS
  Case report and literature review.
  
  
  RESULTS
  The presentation, clinical course, surgical intervention, pathologic analysis, and postoperative outcome of a case of bilateral spontaneous corneal perforation in pellucid marginal degeneration are detailed. All spontaneous corneal perforation cases associated with pellucid marginal degeneration are reviewed.
  
  
  CONCLUSIONS
  Pellucid marginal degeneration can lead to spontaneous corneal perforation resulting in the need for urgent therapeutic intervention. A potential for severe ocular morbidity should be considered in all patients with this disorder despite a seemingly stable disease and appropriate gas permeable contact lens wear. Unilateral perforation cases should be watched closely for development of complications in the fellow eye.
authors.affiliation: Eye Consultants of Atlanta/Piedmont Hospital, 95 Collier Road, Suite 3000, Atlanta, GA 30309, USA. lee0003@aol.com
authors.forename: William Barry
authors.initials: WB
authors.lastname: Lee
authors.forename: Henry S
authors.initials: HS
authors.lastname: O'Halloran
authors.forename: Hans E
authors.initials: HE
authors.lastname: Grossniklaus
mesh_terms: D000328:Adult; D003261:Contact Lenses; D003316:Corneal Diseases / Q000209:etiology* / Q000628:therapy; D019781:Corneal Topography; D004108:Dilatation, Pathologic / Q000150:complications / Q000628:therapy; D005260:Female; D007839:Functional Laterality; D006801:Humans; D015948:Keratoplasty, Penetrating; D012422:Rupture, Spontaneous; D014014:Tissue Adhesives / Q000627:therapeutic use; D014792:Visual Acuity / Q000502:physiology
chemical_list: D014014:Tissue Adhesives
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