Imaging the pancreas: from ex vivo to non-invasive technology.
While many recently published reviews have covered non-invasive nuclear imaging techniques, the aim of this review is to focus on current developments in optical imaging technologies for investigating the pancreas. Several of these modalities are being developed into non-invasive, real-time monitoring routines for pancreatic diseases. However, they also provide pre-clinical ex vivo and/or intravital tools for three-dimensional quantitative assessments of cellular and molecular events, with levels of specificity and resolution difficult to achieve with other currently available modalities.
Holmberg
D
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Department of Medical Biosciences, Umeå University, S-901 87, Umeå, Sweden.
Ahlgren
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D000818:Animals; D003952:Diagnostic Imaging / Q000379:methods*; D017930:Genes, Reporter / Q000235:genetics; D006801:Humans; D008164:Luminescent Proteins / Q000235:genetics / Q000378:metabolism; D010182:Pancreatic Diseases / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism
D008164:Luminescent Proteins
Nat Med. 2006 Jan;12(1):144-8
16380717
Diabetes. 1989 Jun;38(6):808-14
2656348
Immunol Rev. 2008 Feb;221:200-13
18275484
Science. 1990 Apr 6;248(4951):73-6
2321027
Opt Lett. 2006 Aug 15;31(16):2450-2
16880852
Am J Gastroenterol. 2007 Feb;102(2):269-74
17100970
Nat Methods. 2008 Jul;5(7):609-12
18516047
Mol Ther. 2004 Mar;9(3):428-35
15006610
Curr Med Chem. 2006;13(23):2761-73
17073627
Mol Imaging. 2006 Apr-Jun;5(2):65-75
16954020
J Gastroenterol Hepatol. 2007 Dec;22(12):2256-60
18031391
Development. 2004 Oct;131(19):4665-75
15329346
Transplantation. 2006 May 27;81(10):1421-7
16732180
Nat Methods. 2007 Jan;4(1):31-3
17143281
Mol Imaging. 2007 Nov-Dec;6(6):369-83
18053408
Annu Rev Biomed Eng. 2004;6:209-28
15255768
Mol Imaging. 2004 Oct;3(4):333-42
15802050
Transplantation. 2005 Apr 15;79(7):768-76
15818318
Genes Dev. 2006 Aug 15;20(16):2208-13
16912273
J Mol Med (Berl). 2008 Jan;86(1):5-16
17665159
Science. 2002 Apr 19;296(5567):541-5
11964482
Curr Diab Rep. 2006 Aug;6(4):328-32
16879787
Nat Med. 2008 May;14(5):574-8
18327249
Science. 1991 Nov 22;254(5035):1178-81
1957169
Transplantation. 2004 Apr 27;77(8):1133-7
15114073
Endocr Rev. 2007 Oct;28(6):685-705
17881611
Transplant Proc. 2008 Mar;40(2):444-8
18374096
Genesis. 2005 Oct;43(2):80-6
16108006
Transplantation. 2006 Apr 27;81(8):1185-90
16641606
J Clin Endocrinol Metab. 2007 Dec;92(12):4706-11
17895314
J Clin Invest. 2005 Sep;115(9):2454-61
16110329
Diabetes. 2001 Aug;50(8):1763-70
11473036
Magn Reson Med. 2004 Dec;52(6):1228-33
15562474
Transplantation. 2007 Oct 15;84(7):893-8
17984843