title: Changes in neuronal excitability serve as a mechanism of long-term memory for operant conditioning.
abstract: Learning can lead to changes in the intrinsic excitability of neurons. However, the extent to which these changes persist and the role they have in the expression of memory remain unclear. We found that in vitro analogs of operant conditioning produced a long-term (24 h) increase in the excitability of an identified neuron (B51) that is critical for the expression of feeding in Aplysia. This increase in excitability, which was cAMP dependent, contributed to the associative modification of the feeding circuitry, providing a mechanism for long-term memory.
authors.affiliation: Department of Neurobiology and Anatomy, W.M. Keck Center for Neurobiology of Learning and Memory, The University of Texas Medical School at Houston, 6431 Fannin Street, Suite MSB 7.046, Houston, Texas 77030, USA.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Mozzachiodi
authors.forename: Fred D
authors.initials: FD
authors.lastname: Lorenzetti
authors.forename: Douglas A
authors.initials: DA
authors.lastname: Baxter
authors.forename: John H
authors.initials: JH
authors.lastname: Byrne
mesh_terms: D015124:8-Bromo Cyclic Adenosine Monophosphate / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D001048:Aplysia; D001522:Behavior, Animal; D003216:Conditioning, Operant / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D000242:Cyclic AMP / Q000494:pharmacology; D004307:Dose-Response Relationship, Radiation; D004558:Electric Stimulation / Q000379:methods; D005518:Food Preferences; D007839:Functional Laterality; D017952:Ganglia, Invertebrate / Q000166:cytology; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000502:physiology / Q000528:radiation effects; D008568:Memory / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D009474:Neurons / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D018408:Patch-Clamp Techniques / Q000379:methods; D010525:Peripheral Nerves / Q000528:radiation effects; D018709:Statistics, Nonparametric; D013873:Thionucleotides / Q000494:pharmacology
chemical_list: C105593:8-bromoadenosine-3',5'-cyclic monophosphorothioate; D013873:Thionucleotides; D015124:8-Bromo Cyclic Adenosine Monophosphate; D000242:Cyclic AMP
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