Synthesis of oligonucleotide conjugated pyrrolepolyamide- and pyrrole-imidazole polyamide-2'-deoxyguanosine hybrids as novel gene expression control compounds.
DNA oligonucleotide conjugated pyrrolepolyamide- and pyrrole-imidazole polyamide-2'-deoxyguanosine hybrids were efficiently synthesized by a post-synthetic modification method through condensation of the 2-fluoro-2'-deoxyinosine moiety of oligonucleotide 9 and FmocNH-PyXPyPy (X = Py or Im) derivatives.
Kawashima
Etsuko
E
School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan. kawasima@ps.toyaku.ac.jp
Ohba
Yusuke
Y
Kamaike
Kazuo
K
D000241:Adenosine / Q000031:analogs & derivatives* / Q000737:chemistry; D005786:Gene Expression Regulation; D015316:Genetic Therapy; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry*
D009838:Oligodeoxyribonucleotides; D011758:Pyrroles; D000241:Adenosine