Stathmin reveals dissociable roles of the basolateral amygdala in parental and social behaviors.
Innate parental behaviors and adult social interactions are essential for survival of the individual along with the species as a whole. Because these behaviors require threat assessment of the environment, it is plausible that they are regulated by the amygdala-associated neural circuitry of fear. However, the amygdala is not a single anatomic and functional unit, and nuclei of the amygdala have multiple inter- and intra-connections. This poses a question as to the exact role of different amygdala nuclei in these behaviors and the mechanisms involved. The basolateral complex of the amygdala nuclei (BLA) is particularly interesting in this regard: although the BLA role in forming memories for learned fear is established, the BLA role in innate behaviors is not well understood. We recently demonstrated that mice without an inhibitor of microtubules, stathmin, a gene enriched in BLA-associated circuitry, have deficiency in innate and learned fear. Here we show that the deficiency in fear processing in stathmin(-/-) females leads to improper threat assessment, which in turn affects innate parental care and adult social interactions. Profound deficiency is observed in maternal behavior of stathmin(-/-) females: they lack motivation for retrieving pups and are unable to choose a safe location for nest-building. Remarkably, stathmin(-/-) females have an enhancement in social interactions. BLA lesions in WT mice produce similar effects in maternal and social behaviors, confirming vital BLA participation. The findings implicate stathmin as the critical molecular component linking the BLA-associated neural circuitry with innate parental behaviors and adult social interactions.
Martel
Guillaume
G
Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA.
Nishi
Akinori
A
Shumyatsky
Gleb P
GP
D000679:Amygdala / Q000378:metabolism / Q000502:physiology* / Q000601:surgery; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000502:physiology; D005239:Fear / Q000502:physiology; D005260:Female; D005786:Gene Expression Regulation; D016762:Genes, fos / Q000235:genetics; D006728:Hormones / Q000378:metabolism; D007150:Immunohistochemistry; D007323:Instinct; D008297:Male; D008425:Maternal Behavior / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D012919:Social Behavior; D050777:Stathmin / Q000235:genetics / Q000378:metabolism*
D006728:Hormones; D050777:Stathmin; C493994:Stmn1 protein, mouse
Neurosci Biobehav Rev. 2003 Oct;27(6):543-54
14599435
Cell Struct Funct. 1999 Oct;24(5):345-57
15216892
Mol Psychiatry. 2001 Jan;6(1):13-34
11244481
Neuropsychologia. 2003;41(2):235-40
12459222
Neurosci Biobehav Rev. 2002 May;26(3):321-52
12034134
Biol Psychiatry. 2002 Jan 1;51(1):27-43
11801229
Science. 2007 Aug 24;317(5841):1079-83
17717184
Dev Psychobiol. 2007 Jan;49(1):12-21
17186513
Cell. 2002 Dec 13;111(6):905-18
12526815
Biol Psychiatry. 2004 Aug 1;56(3):151-60
15271583
Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15218-23
17005717
Neurosci Biobehav Rev. 1999 May;23(5):743-60
10392663
Prog Brain Res. 2006;156:3-29
17015072
Cell. 2005 Nov 18;123(4):697-709
16286011
J Exp Anal Behav. 1988 Nov;50(3):361-74
3209954
Curr Opin Neurobiol. 2004 Apr;14(2):148-55
15082318
Ann N Y Acad Sci. 2003 Apr;985:174-84
12724158
J Comp Neurol. 2005 Dec 5;493(1):122-31
16254987
Horm Behav. 2006 Nov;50(4):506-17
16890230
Neuroscience. 1999;93(3):855-67
10473251
Physiol Behav. 1980 Nov;25(5):731-43
7443835
Eur J Neurosci. 2003 Apr;17(8):1680-94
12752386
Nature. 1998 Jun 4;393(6684):470-4
9624002
Annu Rev Neurosci. 2000;23:155-84
10845062
Nat Rev Neurosci. 2002 Jul;3(7):563-73
12094212
Behav Cogn Neurosci Rev. 2005 Jun;4(2):119-35
16251728
Histochemistry. 1993 Dec;100(6):431-40
7512949