title: Labeling of Polymer Nanostructures for Medical Imaging: Importance of crosslinking extent, spacer length, and charge density.
abstract: Radiolabeling studies were employed to investigate the influence of structure on the efficiency of surface functionalization for poly(acrylic acid)-coated shell crosslinked nanoparticles (SCKs) with two types of amine-terminated DOTA chelators. An intricate interplay between the chemical and physical properties of both the DOTA derivative and the SCK nanostructures was revealed, demonstrating the importance of structural control.
authors.affiliation: Center of Materials Innovation and Department of Chemistry, Washington University in Saint Louis, Saint Louis, MO 63130.
authors.forename: Jinqi
authors.initials: J
authors.lastname: Xu
authors.forename: Guorong
authors.initials: G
authors.lastname: Sun
authors.forename: Raffaella
authors.initials: R
authors.lastname: Rossin
authors.forename: Aviv
authors.initials: A
authors.lastname: Hagooly
authors.forename: Zicheng
authors.initials: Z
authors.lastname: Li
authors.forename: Ken-Ichi
authors.initials: KI
authors.lastname: Fukukawa
authors.forename: Benjamin W
authors.initials: BW
authors.lastname: Messmore
authors.forename: Dennis A
authors.initials: DA
authors.lastname: Moore
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Welch
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Hawker
authors.forename: Karen L
authors.initials: KL
authors.lastname: Wooley
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