New depot forms of AZT and 3TC based on their phosphonate derivatives: anti-HIV activity and pharmacokinetic parameters.
New phosphonate depot forms of AZT and 3TC were synthesized and their anti-HIV properties in cell systems, cellular uptake, intracellular transformations and some pharmacokinetic and toxicological data were studied.
Kukhanova
M K
MK
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilov St, 119991 Moscow, Russia. kukhan86@hotmail.com
Jasco
M V
MV
Shipitzyn
A V
AV
Yanvarev
D V
DV
Khandazhynskaya
A L
AL
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D002460:Cell Line; D004285:Dogs; D019259:Lamivudine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D051379:Mice; D063065:Organophosphonates / Q000737:chemistry; D015215:Zidovudine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology
D000998:Antiviral Agents; D063065:Organophosphonates; D019259:Lamivudine; D015215:Zidovudine