Forensic toxicological implication of an autopsy case of mixed drug overdose involving clomipramine, chlorpromazine and flunitrazepam.
A case of fatal poisoning involving clomipramine, chlorpromazine and flunitrazepam is presented. Quantitative toxicological analysis showed that the concentrations of clomipramine, chlorpromazine and 7-aminoflunitrazepam (a metabolite of flunitrazepam) in the femoral blood were 3.24 microg/ml, 0.36 Kg/ml and 0.61 microg/ml, respectively, and large amounts of drugs were also detected from the stomach contents. We concluded that the cause of death was due to the combined use of clomipramine, chlorpromazine and flunitrazepam.
Kinoshita
Hiroshi
H
Department of Legal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. kinochin@hyo-med.ac.jp
Nishiguchi
Minori
M
Kasuda
Shogo
S
Takahashi
Motonori
M
Ouchi
Harumi
H
Minami
Takako
T
Matsui
Kiyoshi
K
Yamamura
Takehiko
T
Motomura
Hiroyuki
H
Ohtsu
Nao
N
Yoshida
Shie
S
Adachi
Nobuyuki
N
Ohta
Takehiko
T
Komeda
Motoo
M
Ameno
Kiyoshi
K
Hishida
Shigeru
S
D000328:Adult; D002746:Chlorpromazine / Q000032:analysis / Q000506:poisoning*; D002997:Clomipramine / Q000032:analysis / Q000506:poisoning*; D005260:Female; D005445:Flunitrazepam / Q000032:analysis / Q000506:poisoning*; D006801:Humans; D011619:Psychotropic Drugs / Q000032:analysis / Q000506:poisoning*; D013405:Suicide
D011619:Psychotropic Drugs; D005445:Flunitrazepam; D002997:Clomipramine; D002746:Chlorpromazine