Recognizing and controlling biomolecules with "Smart" hybridization-based switches.
The rules that govern the formation of DNA duplex structures are well known. On one hand, this process is used in the design of probe molecules that report the presence of target nucleic acids by responding to changes of structure and reactivity. On the other hand, molecules may be developed that transduce changes of nucleic acid structure to changes of peptide structure, and vice versa. Applications in the fields of bioanalytical chemistry and synthetic biology are discussed.
Seitz
Oliver
O
Institute of Chemistry, Humboldt University Berlin, Brook-Taylor-Str. 2, D-12489 Berlin, Germany. oliver.seitz@chemie.hu-berlin.de
Grossmann
Tom N
TN
Thurley
Stefanie
S
Röglin
Lars
L
D004789:Enzyme Activation; D009693:Nucleic Acid Hybridization; D015341:Nucleic Acid Probes / Q000737:chemistry*; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D017422:Sequence Analysis, DNA; D018909:src Homology Domains; D019061:src-Family Kinases / Q000378:metabolism
D015341:Nucleic Acid Probes; D020135:Peptide Nucleic Acids; D019061:src-Family Kinases