title: [2% ibopamine vs. water-drinking test as a provocative test for glaucoma].
abstract: OBJECTIVE
  To compare the 2% ibopamine provocative test with the water drinking test as a provocative test for glaucoma.
  
  
  METHODS
  Primary open-angle glaucoma patients and normal individuals were selected from CEROF-Universidade Federal de Goiânia UFG, and underwent the 2% ibopamine provocative test and the water drinking test in a randomized fashion, at least 1 week apart. Intraocular pressure (IOP) before and after both tests, Bland-Altman graph, sensitivity and specificity (as measured by ROC curves) were obtained for both methods.
  
  
  RESULTS
  Forty-seven eyes from 25 patients were included (27 eyes from 15 glaucoma patients and 20 eyes from 10 normal individuals), with a mean age of 54.2 +/- 12.7 years. The mean MD of glaucoma patients was -2.8 +/- 2.11 dB. There was no statistically difference in the baseline IOP (p=0.8) comparing glaucoma patients, but positive after the provocative tests (p=0.03), and in the IOP variation (4.4 +/- 1.3 mmHg for ibopamine and 3.2 +/- 2.2 mmHg for water drinking test, p=0.01). There was no difference in all studied parameters for normal individuals. The Bland-Altman graph showed high dispersion comparing both methods. The areas under the ROC curve were 0.987 for the ibopamine provocative test, and 0.807 for the water-drinking test.
  
  
  CONCLUSIONS
  In this selected subgroup of glaucoma patients with early visual field defect, the ibopamine provocative test has shown better sensitivity/specificity than the water drinking test.
authors.affiliation: Setor de Glaucoma, CEROF, Universidade Federal de Goiânia, Goiânia (GO), Brasil. . lmagacho@brturbo.com.br
authors.forename: Leopoldo
authors.initials: L
authors.lastname: Magacho
authors.forename: Ricardo
authors.initials: R
authors.lastname: Reis
authors.forename: Mara Agi
authors.initials: MA
authors.lastname: Pigini
authors.forename: Marcos Pereira de
authors.initials: MP
authors.lastname: Avila
mesh_terms: D003846:Deoxyepinephrine / Q000031:analogs & derivatives*; D003941:Diagnostic Techniques, Ophthalmological; D004326:Drinking; D004812:Epidemiologic Methods; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008875:Middle Aged; D009184:Mydriatics; D014867:Water
chemical_list: D009184:Mydriatics; D014867:Water; C023487:ibopamine; D003846:Deoxyepinephrine