title: [Analysis of chronic necrotizing pulmonary aspergillosis (CNPA) cases complicated with non-tuberculous mycobacteriosis (NTM)].
abstract: OBJECTIVE
  To clarify the clinical feature of chronic necrotizing pulmonary aspergillosis (CNPA) complicated with non-tuberculous mycobacteriosis (NTM).
  
  
  METHODS
  Forty-one CNPA cases underlying NTM were analyzed according to their clinical backgrounds.
  
  
  RESULTS
  Concerning the radiological type of prior NTM, CNPA cases were classified into two groups; 1) resembling pulmonary tuberculosis that usually shows cavitary lesion and 2) micronodule and bronchiectasis pattern, and more than half of cases (61.0%) were classified as the latter type. Average duration between prior NTM and CNPA was 1354 days. Isolation of Aspergillus spp. from sputum was 15 out of 41 (36.6%). Positive rates for Aspergillus galactomannan antigen and anti-aspergillus antibody were 58.5%, 46.3% respectively. With regard to subspecies of mycobacteria, M. avium was most frequent (82.9%). Since 6.8% of NTM cases develop CNPA within 10 years, careful observation of CNPA was required for the management of NTM.
authors.affiliation: Department of Respiratory Medicine, National Hospital Organization Dohoku National Hospital, 7 Hanasaki, Asahikawa-shi, Hokkaido 070-8644, Japan. fujiuchi@douhoku.hosp.go.jp
authors.forename: Satoru
authors.initials: S
authors.lastname: Fujiuchi
authors.forename: Michiko
authors.initials: M
authors.lastname: Sakunami
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Akinori
authors.initials: A
authors.lastname: Takeda
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nishigaki
authors.forename: Yuka
authors.initials: Y
authors.lastname: Fujita
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yamazaki
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Fujikane
mesh_terms: D000368:Aged; D001228:Aspergillosis / Q000150:complications*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008172:Lung Diseases, Fungal / Q000150:complications*; D008297:Male; D009165:Mycobacterium Infections, Nontuberculous / Q000150:complications*; D009336:Necrosis; D014397:Tuberculosis, Pulmonary / Q000150:complications*