Taumycins A and B, two bioactive lipodepsipeptides from the Madagascar sponge Fascaplysinopsis sp.
Two closely related lipodepsipeptides, taumycins A and B (1 and 2) have been isolated from the Madagascar sponge Fascaplysinopsis sp. The two compounds have the same 12-membered oxodepsipeptide ring system in common. Both were toxic to brine shrimp larvae, and taumycin A (1 microM), but not taumycin B, inhibited growth of the human UT-7 leukemic cell line. The structure of the two compounds, likely to be derived from microorganisms, was established by MS and 1D and 2D NMR data.
Bishara
Ashgan
A
School of Chemistry and Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel.
Rudi
Amira
A
Aknin
Maurice
M
Neumann
Drorit
D
Ben-Califa
Nathalie
N
Kashman
Yoel
Y
D000818:Animals; D001156:Artemia / Q000254:growth & development; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D047630:Depsipeptides / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D006801:Humans; D007814:Larva / Q000187:drug effects; D008270:Madagascar; D010455:Peptides / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D011161:Porifera / Q000737:chemistry*
D047630:Depsipeptides; D010455:Peptides; C532773:taumycin A; C532774:taumycin B