title: Caspase cleavage is not for everyone.
abstract: During apoptosis, caspases cleave cellular substrates to break down and package the apoptotic cell for removal. Reporting in Cell, Mahrus et al. (2008) and Dix et al. (2008) use new approaches that identify hundreds of previously unrecognized caspase substrates, many of which appear to produce polypeptide fragments with potentially new functional activities.
authors.affiliation: Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.
authors.forename: Carrie E
authors.initials: CE
authors.lastname: Johnson
authors.forename: Sally
authors.initials: S
authors.lastname: Kornbluth
mesh_terms: D017209:Apoptosis; D020169:Caspases / Q000378:metabolism*; D006801:Humans; D019169:Jurkat Cells; D011506:Proteins / Q000032:analysis* / Q000378:metabolism*; D013379:Substrate Specificity
chemical_list: D011506:Proteins; D020169:Caspases