title: Timing in cellular Ca2+ signaling.
abstract: Calcium (Ca2+) signals are generated across a broad time range. Kinetic considerations impact how information is processed to encode and decode Ca2+ signals, the choreography of responses that ensure specific and efficient signaling and the overall temporal amplification such that ephemeral Ca2+ signals have lasting physiological value. The reciprocal importance of timing for Ca2+ signaling, and Ca2+ signaling for timing is exemplified by the altered kinetic profiles of Ca2+ signals in certain diseases and the likely role of basal Ca2+ fluctuations in the perception of time itself.
authors.affiliation: Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Boulware
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Marchant
mesh_terms: D002118:Calcium / Q000737:chemistry; D020013:Calcium Signaling / Q000502:physiology*; D025461:Feedback, Physiological; D007700:Kinetics; D008954:Models, Biological; D013997:Time Factors
chemical_list: D002118:Calcium
references.citation: Nature. 1995 Jun 29;375(6534):784-7
references.pmid: 7596410
references.citation: Nat Rev Mol Cell Biol. 2000 Oct;1(1):11-21
references.pmid: 11413485
references.citation: Neuron. 2003 Apr 24;38(2):253-63
references.pmid: 12718859
references.citation: Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4700-5
references.pmid: 17360587
references.citation: Nat Cell Biol. 2002 Nov;4(11):E263-72
references.pmid: 12415286
references.citation: Cell Calcium. 2007 Mar;41(3):207-19
references.pmid: 16914198
references.citation: Nature. 2002 May 16;417(6886):295-9
references.pmid: 12015605
references.citation: Neuroscience. 2007 Dec 5;150(2):335-45
references.pmid: 17949918
references.citation: Physiol Rev. 2006 Jan;86(1):25-88
references.pmid: 16371595
references.citation: Trends Neurosci. 2006 Jan;29(1):48-57
references.pmid: 16325278
references.citation: Nature. 1998 Apr 30;392(6679):933-6
references.pmid: 9582075
references.citation: Curr Biol. 1997 Jul 1;7(7):510-8
references.pmid: 9210378
references.citation: Nature. 1998 Oct 22;395(6704):805-8
references.pmid: 9796815
references.citation: Proc Natl Acad Sci U S A. 2005 May 24;102(21):7577-82
references.pmid: 15890781
references.citation: Trends Pharmacol Sci. 2006 Feb;27(2):78-84
references.pmid: 16412523
references.citation: Nat Neurosci. 2000 Nov;3 Suppl:1178-83
references.pmid: 11127835
references.citation: Science. 2003 Feb 28;299(5611):1410-3
references.pmid: 12610310
references.citation: Nature. 1997 Apr 24;386(6627):855-8
references.pmid: 9126747
references.citation: Annu Rev Physiol. 2008;70:273-99
references.pmid: 17850212
references.citation: Mol Cell. 2007 Feb 23;25(4):491-503
references.pmid: 17317623
references.citation: J Cell Biol. 2005 Jul 18;170(2):183-90
references.pmid: 16009725
references.citation: Nature. 2006 Dec 7;444(7120):707-12
references.pmid: 17151658
references.citation: Cell. 2005 Dec 2;123(5):849-60
references.pmid: 16325579
references.citation: J Neurochem. 2001 Nov;79(4):849-58
references.pmid: 11723177
references.citation: Cell. 2007 Dec 14;131(6):1047-58
references.pmid: 18083096
references.citation: Philos Trans R Soc Lond B Biol Sci. 2001 Nov 29;356(1415):1725-33
references.pmid: 11710979
references.citation: Cell. 1997 Oct 31;91(3):367-73
references.pmid: 9363945
references.citation: Nat Med. 2007 Dec;13(12):1490-5
references.pmid: 17965720
references.citation: Nat Rev Neurosci. 2007 Mar;8(3):182-93
references.pmid: 17311005
references.citation: Science. 2007 Mar 9;315(5817):1423-6
references.pmid: 17347443
references.citation: J Biol Chem. 2005 May 6;280(18):17678-86
references.pmid: 15743764
references.citation: Nature. 2004 Jan 8;427(6970):121-8
references.pmid: 14712268
references.citation: J Neurosci. 2004 Sep 29;24(39):8394-8
references.pmid: 15456810
references.citation: Nat Immunol. 2006 Jan;7(1):25-32
references.pmid: 16357855
references.citation: Neuron. 2007 May 3;54(3):357-69
references.pmid: 17481390
references.citation: J Cell Biol. 2003 Jul 21;162(2):293-303
references.pmid: 12860966
references.citation: Nature. 2005 Mar 3;434(7029):99-104
references.pmid: 15744307
references.citation: Trends Pharmacol Sci. 2005 Dec;26(12):645-53
references.pmid: 16253351
references.citation: Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):157-61
references.pmid: 9874788
references.citation: Biochim Biophys Acta. 2006 Nov;1763(11):1216-28
references.pmid: 17005265
references.citation: Biol Cell. 2000 Jul;92(3-4):277-84
references.pmid: 11043415
references.citation: Science. 1998 Feb 6;279(5352):870-3
references.pmid: 9452388
references.citation: Science. 1995 Sep 29;269(5232):1863-5
references.pmid: 7569925
references.citation: Cell Calcium. 2005 Sep-Oct;38(3-4):439-46
references.pmid: 16099039
references.citation: J Neurobiol. 1991 Oct;22(7):659-73
references.pmid: 1722506
references.citation: Neuron. 2005 Jan 20;45(2):257-68
references.pmid: 15664177
references.citation: Science. 1998 Jan 9;279(5348):227-30
references.pmid: 9422695
references.citation: Neuropsychopharmacology. 2008 Jan;33(1):18-41
references.pmid: 17728696
references.citation: Biochim Biophys Acta. 1992 Dec 11;1113(3-4):295-305
references.pmid: 1450203
references.citation: Nature. 1986 Feb 13-19;319(6054):600-2
references.pmid: 3945348
references.citation: Nature. 2001 Jun 14;411(6839):801-5
references.pmid: 11459059
references.citation: Cell Signal. 2003 Mar;15(3):243-53
references.pmid: 12531423
references.citation: J Biol Chem. 2004 Mar 12;279(11):10206-14
references.pmid: 14699099
references.citation: Science. 2008 Mar 14;319(5869):1543-6
references.pmid: 18339943
references.citation: J Cell Biol. 2005 Nov 7;171(3):537-47
references.pmid: 16275756
references.citation: Nat Rev Neurosci. 2008 Jan;9(1):65-75
references.pmid: 18094707
references.citation: J Physiol. 1999 Nov 15;521 Pt 1:201-11
references.pmid: 10562345
references.citation: Physiol Rev. 2007 Apr;87(2):457-506
references.pmid: 17429038
references.citation: J Physiol. 2002 Dec 1;545(2):615-27
references.pmid: 12456838
references.citation: Neuron. 2006 Oct 19;52(2):255-69
references.pmid: 17046689
references.citation: Nature. 2001 Jun 28;411(6841):1053-7
references.pmid: 11429606
references.citation: Circulation. 2006 Sep 5;114(10):1012-9
references.pmid: 16908766
references.citation: Science. 2003 Oct 31;302(5646):885-9
references.pmid: 14593183
references.citation: Biochem J. 2006 Jul 15;397(2):313-20
references.pmid: 16551267
references.citation: J Biol Chem. 2006 Aug 11;281(32):22882-95
references.pmid: 16766529
references.citation: J Neurosci. 2005 May 11;25(19):4844-55
references.pmid: 15888660
references.citation: Dev Biol. 2005 Jun 1;282(1):39-54
references.pmid: 15936328
references.citation: Science. 2007 Dec 14;318(5857):1789-92
references.pmid: 18084825
references.citation: Dev Biol. 2007 Jul 1;307(1):1-13
references.pmid: 17531967
references.citation: Nat Methods. 2007 Nov;4(11):943-50
references.pmid: 17965719
references.citation: Neuron. 2004 Sep 16;43(6):859-69
references.pmid: 15363396
references.citation: Cell. 2007 Oct 5;131(1):80-92
references.pmid: 17923089
references.citation: Biochim Biophys Acta. 2007 Aug;1772(8):937-46
references.pmid: 17616360
references.citation: Physiol Rev. 2007 Apr;87(2):593-658
references.pmid: 17429043
references.citation: Neuron. 2003 Oct 9;40(2):319-30
references.pmid: 14556711
references.citation: Science. 2006 Aug 25;313(5790):1141-4
references.pmid: 16931766
references.citation: Am J Physiol. 1997 Sep;273(3 Pt 1):C822-5
references.pmid: 9316401
references.citation: Nat Neurosci. 2006 Oct;9(10):1237-9
references.pmid: 16998481
references.citation: EMBO J. 2002 Jul 15;21(14):3590-7
references.pmid: 12110572
references.citation: J Biol Chem. 1995 Apr 7;270(14):8102-7
references.pmid: 7713913
references.citation: J Physiol. 2000 Dec 15;529 Pt 3:625-46
references.pmid: 11118494
references.citation: Biol Reprod. 2002 Jun;66(6):1828-37
references.pmid: 12021069
references.citation: J Biol Chem. 2005 May 27;280(21):20530-8
references.pmid: 15769749
references.citation: J Theor Biol. 1981 Jun 21;90(4):531-44
references.pmid: 6272030
references.citation: Cell. 2004 Oct 1;119(1):19-31
references.pmid: 15454078
references.citation: Nat Rev Mol Cell Biol. 2003 Jul;4(7):517-29
references.pmid: 12838335
references.citation: Neuron. 2007 May 24;54(4):567-81
references.pmid: 17521570
references.citation: J Biol Chem. 2001 Aug 3;276(31):29353-60
references.pmid: 11384969
references.citation: Dev Biol. 2006 Dec 15;300(2):534-44
references.pmid: 16996050
references.citation: EMBO J. 1999 Oct 1;18(19):5285-99
references.pmid: 10508162
references.citation: Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2011-6
references.pmid: 18250319
references.citation: Science. 2005 Oct 21;310(5747):496-8
references.pmid: 16239477
references.citation: J Neurochem. 1998 Sep;71(3):1075-85
references.pmid: 9721732
references.citation: J Cell Sci. 2006 Mar 1;119(Pt 5):828-36
references.pmid: 16478784
references.citation: Nature. 2003 Feb 6;421(6923):634-9
references.pmid: 12571597
references.citation: Dev Biol. 2001 Feb 15;230(2):258-77
references.pmid: 11161577
references.citation: Endocr Rev. 2005 Feb;26(1):63-77
references.pmid: 15689573
references.citation: Nature. 1998 Apr 30;392(6679):936-41
references.pmid: 9582076
references.citation: J Biol Chem. 2004 Aug 20;279(34):35595-603
references.pmid: 15208303
references.citation: Cell. 1998 Oct 30;95(3):307-18
references.pmid: 9814702
references.citation: Nat Neurosci. 2000 Sep;3(9):881-6
references.pmid: 10966618
references.citation: Curr Biol. 2005 Apr 26;15(8):765-70
references.pmid: 15854911
references.citation: Dev Cell. 2002 Jun;2(6):695-706
references.pmid: 12062082
references.citation: J Cell Biol. 2007 Nov 19;179(4):717-31
references.pmid: 17998397
references.citation: Annu Rev Physiol. 2006;68:193-221
references.pmid: 16460271
references.citation: Mol Cell. 2001 Mar;7(3):651-60
references.pmid: 11463389
references.citation: Curr Biol. 2001 May 1;11(9):R352-5
references.pmid: 11369246
references.citation: J Neurosci. 2008 Jan 2;28(1):133-42
references.pmid: 18171931
references.citation: J Biol Chem. 2000 Jul 21;275(29):21905-13
references.pmid: 10764773
references.citation: J Cell Biol. 2003 Jun 9;161(5):899-909
references.pmid: 12782683
references.citation: J Neurosci. 2003 Jan 1;23(1):103-11
references.pmid: 12514206
references.citation: Dev Biol. 1993 Dec;160(2):512-8
references.pmid: 8253280
references.citation: Science. 2003 Mar 21;299(5614):1859-63
references.pmid: 12649474
references.citation: Nature. 1997 Apr 24;386(6627):759-60
references.pmid: 9126727
references.citation: Proc Natl Acad Sci U S A. 2007 May 29;104(22):9301-6
references.pmid: 17517596