title: Gluten ataxia.
abstract: Gluten ataxia is an immune-mediated disease triggered by the ingestion of gluten in genetically susceptible individuals. It should be considered in the differential diagnosis of all patients with idiopathic sporadic ataxia. Early diagnosis and treatment with a gluten free diet can improve ataxia and prevent its progression. Readily available and sensitive markers of gluten ataxia include antigliadin antibodies. IgA deposits against TG2 in the small bowel and at extraintestinal sites are proving to be additional reliable and perhaps more specific markers of the whole spectrum of gluten sensitivity. They may also hold the key to its pathogenesis.
authors.affiliation: Department of Neurology, The Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Trust, Sheffield, UK. m.hadjivassiliou@sheffield.ac.uk
authors.forename: Marios
authors.initials: M
authors.lastname: Hadjivassiliou
authors.forename: David S
authors.initials: DS
authors.lastname: Sanders
authors.forename: Nicola
authors.initials: N
authors.lastname: Woodroofe
authors.forename: Claire
authors.initials: C
authors.lastname: Williamson
authors.forename: Richard A
authors.initials: RA
authors.lastname: Grünewald
mesh_terms: D001259:Ataxia / Q000139:chemically induced* / Q000453:epidemiology; D002446:Celiac Disease / Q000453:epidemiology / Q000503:physiopathology*; D002526:Cerebellar Diseases / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology*; D000939:Epitopes / Q000032:analysis; D005983:Glutens / Q000633:toxicity*; D006801:Humans; D015995:Prevalence; D011689:Purkinje Cells / Q000187:drug effects / Q000473:pathology / Q000502:physiology
chemical_list: D000939:Epitopes; D005983:Glutens
references.citation: J Neurol Neurosurg Psychiatry. 2003 Sep;74(9):1221-4
references.pmid: 12933922
references.citation: J Neurol Neurosurg Psychiatry. 1999 Jan;66(1):32-5
references.pmid: 9886447
references.citation: Mov Disord. 2004 Apr;19(4):478-82
references.pmid: 15077250
references.citation: Intern Med. 2006;45(3):135-40
references.pmid: 16508226
references.citation: Pediatr Neurol. 2006 Apr;34(4):312-4
references.pmid: 16638509
references.citation: Brain. 2003 Mar;126(Pt 3):685-91
references.pmid: 12566288
references.citation: Brain. 2001 May;124(Pt 5):1013-9
references.pmid: 11335703
references.citation: Trends Immunol. 2004 Nov;25(11):578-82
references.pmid: 15489185
references.citation: Eur J Gastroenterol Hepatol. 2003 Apr;15(4):407-13
references.pmid: 12655262
references.citation: Nat Med. 1997 Jul;3(7):797-801
references.pmid: 9212111
references.citation: Neurology. 2003 May 27;60(10):1674-5
references.pmid: 12771263
references.citation: Neurology. 2002 Apr 23;58(8):1221-6
references.pmid: 11971090
references.citation: Ann Neurol. 2001 Apr;49(4):540-3
references.pmid: 11310636
references.citation: Brain. 2002 May;125(5):961-8
references.pmid: 11960886
references.citation: Neurology. 2006 Feb 14;66(3):373-7
references.pmid: 16476935
references.citation: Neurology. 1999 Oct 22;53(7):1606-8
references.pmid: 10534283
references.citation: Ann Neurol. 2001 Dec;50(6):827-8
references.pmid: 11761488
references.citation: Neurology. 2004 Jan 13;62(1):132-3
references.pmid: 14718716
references.citation: Neurology. 1985 Aug;35(8):1199-201
references.pmid: 4022355
references.citation: Brain. 1995 Oct;118 ( Pt 5):1087-93
references.pmid: 7496772
references.citation: Lancet. 1998 Nov 14;352(9140):1582-5
references.pmid: 9843103
references.citation: Ann Med. 2001 Sep;33(6):445-9
references.pmid: 11585106
references.citation: Neurology. 2001 Feb 13;56(3):385-8
references.pmid: 11171906
references.citation: Brain. 1966 Dec;89(4):683-722
references.pmid: 4163580
references.citation: J Exp Med. 2002 Mar 18;195(6):747-57
references.pmid: 11901200
references.citation: Gut. 2004 May;53(5):641-8
references.pmid: 15082580
references.citation: Neurology. 1988 Apr;38(4):642-5
references.pmid: 2832786
references.citation: J Neurol Neurosurg Psychiatry. 2005 Jul;76(7):1011-3
references.pmid: 15965215