Sleep symptoms and their clinical correlates in Machado-Joseph disease.
OBJECTIVE
To evaluate the presence of sleep symptoms in Machado-Joseph disease/spinocerebellar ataxia type 3 (MJD/SCA3).


METHODS
We used a sleep questionnaire and the Epworth Sleepiness Scale to compare 53 patients with MJD/SCA3 and 106 controls.


RESULTS
Patients with MJD/SCA3 reported more symptoms of insomnia, restless leg syndrome and REM sleep behavior disorder as well as nocturnal cramps, snoring and nocturnal apnea. Insomnia was the most frequently reported sleep-related complaint in the MJD/SCA3 group.


CONCLUSIONS
Our results indicate that sleep disorders are common in patients with MJD/SCA3 and probably have a multifactorial etiology, with components of a primary sleep disorder in addition to sleep-disrupting symptoms such as nocturia and cramps.
D'Abreu
A
A
University of Campinas, Brazil.
França
M
M
Conz
L
L
Friedman
J H
JH
Nucci
A M
AM
Cendes
F
F
Lopes-Cendes
I
I
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D007407:Interviews as Topic; D017827:Machado-Joseph Disease / Q000150:complications* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012890:Sleep; D012893:Sleep Wake Disorders / Q000150:complications*; D012913:Snoring / Q000150:complications; D011795:Surveys and Questionnaires; D055815:Young Adult