Properties of superparamagnetic iron oxide nanoparticles assembled on nucleic acids.
We report the direct modification of SPIOs with a biomolecule, and the sequence-specific assembly of the modified SPIOs was achieved with the aptamer-small molecule interaction. In addition, the transverse relaxation rate of the aqueous solutions containing the modified SPIOs was altered by the dispersion state.
Tanaka
Kazuo
K
Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Nishikyoku, Kyoto 615-8510, Japan.
Kitamura
Narufumi
N
Chujo
Yoshiki
Y
D052157:Aptamers, Nucleotide / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry*; D006427:Hemin / Q000737:chemistry; D008279:Magnetic Resonance Imaging; D053768:Metal Nanoparticles / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular
D052157:Aptamers, Nucleotide; D005290:Ferric Compounds; C000499:ferric oxide; D006427:Hemin; D004247:DNA