Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis in a Chinese Han population.
BACKGROUND
Rhinitis and asthma are very common diseases involving genetic and environmental factors. Most patients with asthma also have rhinitis, which suggests the concept of 'one airway, one disease.' A disintegrin and metalloproteinase 33 (ADAM33) is the first asthma-susceptible gene to be discovered by positional cloning. To evaluate the potential influence of ADAM33 gene polymorphisms on allergic rhinitis (AR) and allergic asthma (AS), a case-control study was conducted on the Han population of northeast China.


METHODS
Six polymorphic sites (V4, T+1, T2, T1, S1, and Q-1) were genotyped in 128 patients with AR, 181 patients with AS, and 151 healthy controls (CTR). Genotypes were determined by the polymerase chain restriction fragment length polymorphism (PCR-RFLP) method. Data were analyzed using the chi-square test with Haploview software.


RESULTS
The single nucleotide polymorphisms (SNPs), V4 G/C, T+1 A/G, and T1 G/A, of the ADAM33 gene may be the causal variants in AR, whereas ADAM33 V4 G/C, T2 A/G, T1 G/A, and Q-1A/G may participate in the susceptibility of AS.


CONCLUSIONS
These results suggest that polymorphisms of the ADAM33 gene may modify individual susceptibility to AR and AS in a Chinese Han population.
Su
Dongju
D
Department of Respiratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, PR China. sudongju@yahoo.com.cn
Zhang
Ximei
X
Sui
Hong
H
Lü
Fuzhen
F
Jin
Lianhong
L
Zhang
Jing
J
D051722:ADAM Proteins / Q000235:genetics*; D000328:Adult; D000483:Alleles; D001249:Asthma / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D015331:Cohort Studies; D005006:Ethnicity; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012221:Rhinitis, Allergic, Perennial / Q000235:genetics*
D051722:ADAM Proteins; C450441:ADAM33 protein, human
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