title: Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer.
abstract: Three recent genome-wide association studies identified associations between markers in the chromosomal region 15q24-25.1 and the risk of lung cancer. We conducted a genome-wide association analysis to investigate associations between single-nucleotide polymorphisms (SNPs) and the risk of lung cancer, in which we used blood DNA from 194 case patients with familial lung cancer and 219 cancer-free control subjects. We identified associations between common sequence variants at 15q24-25.1 (that spanned LOC123688 [a hypothetical gene], PSMA4, CHRNA3, CHRNA5, and CHRNB4) and lung cancer. The risk of lung cancer was more than fivefold higher among those subjects who had both a family history of lung cancer and two copies of high-risk alleles rs8034191 (odds ratio [OR] = 7.20, 95% confidence interval [CI] = 2.21 to 23.37) or rs1051730 (OR = 5.67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects. Thus, further research to elucidate causal variants in the 15q24-25.1 locus that are associated with lung cancer is warranted.
authors.affiliation: Washington University, St Louis, MO 63110, USA.
authors.forename: Pengyuan
authors.initials: P
authors.lastname: Liu
authors.forename: Haris G
authors.initials: HG
authors.lastname: Vikis
authors.forename: Daolong
authors.initials: D
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Lu
authors.forename: Yian
authors.initials: Y
authors.lastname: Wang
authors.forename: Ann G
authors.initials: AG
authors.lastname: Schwartz
authors.forename: Susan M
authors.initials: SM
authors.lastname: Pinney
authors.forename: Ping
authors.initials: P
authors.lastname: Yang
authors.forename: Mariza
authors.initials: M
authors.lastname: de Andrade
authors.forename: Gloria M
authors.initials: GM
authors.lastname: Petersen
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Wiest
authors.forename: Pamela R
authors.initials: PR
authors.lastname: Fain
authors.forename: Adi
authors.initials: A
authors.lastname: Gazdar
authors.forename: Colette
authors.initials: C
authors.lastname: Gaba
authors.forename: Henry
authors.initials: H
authors.lastname: Rothschild
authors.forename: Diptasri
authors.initials: D
authors.lastname: Mandal
authors.forename: Teresa
authors.initials: T
authors.lastname: Coons
authors.forename: Juwon
authors.initials: J
authors.lastname: Lee
authors.forename: Elena
authors.initials: E
authors.lastname: Kupert
authors.forename: Daniela
authors.initials: D
authors.lastname: Seminara
authors.forename: John
authors.initials: J
authors.lastname: Minna
authors.forename: Joan E
authors.initials: JE
authors.lastname: Bailey-Wilson
authors.forename: Xifeng
authors.initials: X
authors.lastname: Wu
authors.forename: Margaret R
authors.initials: MR
authors.lastname: Spitz
authors.forename: Timothy
authors.initials: T
authors.lastname: Eisen
authors.forename: Richard S
authors.initials: RS
authors.lastname: Houlston
authors.forename: Christopher I
authors.initials: CI
authors.lastname: Amos
authors.forename: Marshall W
authors.initials: MW
authors.lastname: Anderson
authors.forename: Ming
authors.initials: M
authors.lastname: You
mesh_terms: D016022:Case-Control Studies; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics; D015986:Confounding Factors, Epidemiologic; D004273:DNA, Neoplasm / Q000032:analysis*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012107:Research Design; D017422:Sequence Analysis, DNA; D012907:Smoking / Q000009:adverse effects
chemical_list: D004273:DNA, Neoplasm
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