title: Synthesis and antiviral evaluation of conformationally fixed bicyclohexanyl nucleosides with ethenyl group at C3'-position.
abstract: Conformationally fixed bicyclo[3.1.0]hexanyl nucleosides 1 and 2 with C3'-ethenyl group were successfully synthesized and evaluated against various viruses. Carbenoid intramolecular cycloaddition and diastereoselective Grignard reaction were employed as the key reaction steps.
authors.affiliation: College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan 609-735, Korea.
authors.forename: Won Hee
authors.initials: WH
authors.lastname: Kim
authors.forename: Kyung Ran
authors.initials: KR
authors.lastname: Kim
authors.forename: Ah-Young
authors.initials: AY
authors.lastname: Park
authors.forename: Hyung-Rock
authors.initials: HR
authors.lastname: Lee
authors.forename: Jin-Ah
authors.initials: JA
authors.lastname: Kang
authors.forename: Jang Ho
authors.initials: JH
authors.lastname: Bae
authors.forename: Lak Shin
authors.initials: LS
authors.lastname: Jeong
authors.forename: Hyung Ryong
authors.initials: HR
authors.lastname: Moon
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D001643:Bridged Bicyclo Compounds; D000241:Adenosine