title: White fat progenitor cells reside in the adipose vasculature.
abstract: White adipose (fat) tissues regulate metabolism, reproduction, and life span. Adipocytes form throughout life, with the most marked expansion of the lineage occurring during the postnatal period. Adipocytes develop in coordination with the vasculature, but the identity and location of white adipocyte progenitor cells in vivo are unknown. We used genetically marked mice to isolate proliferating and renewing adipogenic progenitors. We found that most adipocytes descend from a pool of these proliferating progenitors that are already committed, either prenatally or early in postnatal life. These progenitors reside in the mural cell compartment of the adipose vasculature, but not in the vasculature of other tissues. Thus, the adipose vasculature appears to function as a progenitor niche and may provide signals for adipocyte development.
authors.affiliation: Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Tang
authors.forename: Daniel
authors.initials: D
authors.lastname: Zeve
authors.forename: Jae Myoung
authors.initials: JM
authors.lastname: Suh
authors.forename: Darko
authors.initials: D
authors.lastname: Bosnakovski
authors.forename: Michael
authors.initials: M
authors.lastname: Kyba
authors.forename: Robert E
authors.initials: RE
authors.lastname: Hammer
authors.forename: Michelle D
authors.initials: MD
authors.lastname: Tallquist
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Graff
mesh_terms: D052438:Adipocytes, White / Q000166:cytology* / Q000378:metabolism; D050156:Adipogenesis; D000273:Adipose Tissue / Q000098:blood supply* / Q000166:cytology; D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D001808:Blood Vessels / Q000166:cytology*; D019070:Cell Lineage; D049109:Cell Proliferation; D002469:Cell Separation; D002478:Cells, Cultured; D004318:Doxycycline / Q000494:pharmacology; D020869:Gene Expression Profiling; D051379:Mice; D008822:Mice, Transgenic; D039902:Multipotent Stem Cells / Q000166:cytology* / Q000378:metabolism; D047495:PPAR gamma / Q000235:genetics / Q000378:metabolism; D017154:Stromal Cells / Q000166:cytology* / Q000378:metabolism
chemical_list: D015703:Antigens, CD; D047495:PPAR gamma; D004318:Doxycycline
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