[An amphibian model for the study of evolutionary respiratory control].
Recent perinal advances have made possible that premature newborns survive increasingtly in earlier developmental stages. This babies requires sophisticated and costly critical intensive care to address the problems associated with inmadurity of the respiratory system. In addition respiratory instability and apnea reflecting inmaturity of the respiratory control system are major causes of morbidity and prolonged hospitalization in this highly vulnerable group of patients. These concerns have contributed to the development of research in respiratoy evolutionary neurobiology. While the majority of researchers working in this field use rodents as an animal model, recent research using in vitro brainstem preparations from bullfrog (Rana catesbeiana) have reveled the technical advantages of this model to study the basic principles underlying respiratory control and its ontogeny between vertebrates. The present article review the recent advances in the area of research with special interest on episodic breathing and the role of serotoninergic and GABAergic modulation of respiratory control during development.
Cuestas
Eduardo
E
Servicio de Pediatría y Neonatología, Hospital Privado, Centro Formador, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba. ecuestas@hospitalprivadosa.com.ar
Bas
José
J
D000663:Amphibians / Q000502:physiology*; D000818:Animals; D005075:Biological Evolution; D023421:Models, Animal; D009446:Neurobiology / Q000379:methods; D012123:Pulmonary Ventilation / Q000502:physiology; D011892:Rana catesbeiana; D012119:Respiration; D015656:Respiratory Mechanics / Q000502:physiology; D012143:Respiratory Physiological Phenomena; D012137:Respiratory System / Q000196:embryology*