title: Molecular biology of pancreatic cancer.
abstract: Pancreatic cancer is a leading cause of cancer death. This devastating disease has the horrible honour of close to equal incidence and mortality rates. Late diagnosis and a constitutive resistance to every chemotherapy approach are responsible for this scenario. However, molecular biology tools in cooperation with translational efforts have dissected several secrets that underlie pancreatic cancer. Progressive acquisition of malignant, invasive phenotypes from pre-malignant lesions, recent revelations on core signalling pathways and new targeted designed trials offer a better future for pancreatic cancer patients. This review will summarise recent advances in the molecular biology of pancreatic cancer.
authors.affiliation: Translational Oncology Unit CSIC/JAM at Medical Oncology Division, University Hospital La Paz, Universidad Autónoma de Madrid, Madrid, Spain.
authors.forename: Cristóbal
authors.initials: C
authors.lastname: Belda-Iniesta
authors.forename: Immaculada
authors.initials: I
authors.lastname: Ibáñez de Cáceres
authors.forename: Jorge
authors.initials: J
authors.lastname: Barriuso
authors.forename: Javier
authors.initials: J
authors.lastname: de Castro Carpeño
authors.forename: Manuel
authors.initials: M
authors.lastname: González Barón
authors.forename: Jaime
authors.initials: J
authors.lastname: Feliú
mesh_terms: D020022:Genetic Predisposition to Disease; D006801:Humans; D008967:Molecular Biology; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy
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