title: Circulating levels of lectin-like oxidized low-density lipoprotein receptor-1 are associated with inflammatory markers.
abstract: Lectin-like oxidized-low-density lipoprotein receptor-1 (LOX-1) is increasingly linked to atherosclerotic plaque formation and the soluble form of this receptor may reflect activities of disease. We investigated the associations among levels of sLOX-1, oxidized-low-density lipoprotein (ox-LDL), cytokines and the extension of atherosclerosis in patients with coronary artery disease (CAD). Lipid, TNF-alpha, IL-6, C reactive protein (CRP), ox-LDL, peroxy radical and sLOX-1 levels were measured in 29 controls and 60 patients with CAD, 30 of which with one or two vessels involved (group 1), and 30 patients with three or four vessels involved (group 2). The serum levels of sLOX-1 were significantly and progressively higher in group 1 [611 (346-1,313) pg/ml, median (interquartile range)] and in group 2 [2,143 (824-3,201) pg/ml] than in control subjects [268 (111-767) pg/ml]. LOX-1 levels positively correlated with IL-6 (r = 0.38, P = 0.0042), TNF-alpha (r = 0.38, P = 0.0037), CRP levels (r = 0.32, P = 0.027) and age (r = 0.25, P = 0.048). In the multivariate analysis TNF-alpha resulted the only independent determinant of LOX-1 serum levels (beta-value = 0.304, P = 0.017). These findings suggest that sLOX-1 levels are up-regulated during CAD progression and are associated with inflammatory markers. The measurement of the circulating soluble form of this receptor may be potentially useful in predicting CAD progression in humans.
authors.affiliation: Institute of Clinical Physiology CNR and G. Monasterio foundation, Via Moruzzi, 1, 56124, Pisa, Italy.
authors.forename: Valter
authors.initials: V
authors.lastname: Lubrano
authors.forename: Serena
authors.initials: S
authors.lastname: Del Turco
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Nicolini
authors.forename: Pietro
authors.initials: P
authors.lastname: Di Cecco
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Basta
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D003324:Coronary Artery Disease / Q000097:blood*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008055:Lipids / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D051127:Scavenger Receptors, Class E / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D008055:Lipids; D008077:Lipoproteins, LDL; D051127:Scavenger Receptors, Class E; D014409:Tumor Necrosis Factor-alpha; C099252:oxidized low density lipoprotein; D002097:C-Reactive Protein
references.citation: Circulation. 1996 Mar 15;93(6):1107-13
references.pmid: 8653830
references.citation: Circ Res. 1998 Aug 10;83(3):322-7
references.pmid: 9710125
references.citation: Int J Cardiol. 2009 May 15;134(2):285-7
references.pmid: 18367271
references.citation: Arterioscler Thromb Vasc Biol. 2001 Apr;21(4):560-6
references.pmid: 11304473
references.citation: Biochem J. 1998 Aug 15;334 ( Pt 1):9-13
references.pmid: 9693095
references.citation: Biochem J. 2008 Jan 15;409(2):349-55
references.pmid: 18092947
references.citation: Circ Res. 2005 Jul 22;97(2):176-84
references.pmid: 15961718
references.citation: Arterioscler Thromb Vasc Biol. 2000 Mar;20(3):715-20
references.pmid: 10712396
references.citation: Circulation. 2005 Aug 9;112(6):812-8
references.pmid: 16061745
references.citation: J Biol Chem. 2002 Nov 29;277(48):45898-903
references.pmid: 12270921
references.citation: J Lipid Res. 2008 Jul;49(7):1438-44
references.pmid: 18408244
references.citation: Circ Res. 2004 Oct 29;95(9):877-83
references.pmid: 15472120
references.citation: J Biol Chem. 2001 Mar 2;276(9):6343-9
references.pmid: 11102451
references.citation: J Clin Invest. 1995 Mar;95(3):1262-70
references.pmid: 7533787
references.citation: Circulation. 1994 Jan;89(1):36-44
references.pmid: 8281670
references.citation: FEBS Lett. 1998 Nov 27;440(1-2):29-32
references.pmid: 9862418
references.citation: Cytokine Growth Factor Rev. 1996 Oct;7(3):231-40
references.pmid: 8971478
references.citation: Nature. 1997 Mar 6;386(6620):73-7
references.pmid: 9052782
references.citation: Circ Res. 2007 Jun 8;100(11):1634-42
references.pmid: 17478727