Pellucid marginal degeneration and bilateral corneal perforation: case report and review of the literature.
OBJECTIVE
To review corneal perforation cases in pellucid marginal degeneration and report a case of bilateral spontaneous perforation at presentation in rigid gas permeable contact lens wear and pellucid marginal degeneration.


METHODS
Case report and literature review.


RESULTS
The presentation, clinical course, surgical intervention, pathologic analysis, and postoperative outcome of a case of bilateral spontaneous corneal perforation in pellucid marginal degeneration are detailed. All spontaneous corneal perforation cases associated with pellucid marginal degeneration are reviewed.


CONCLUSIONS
Pellucid marginal degeneration can lead to spontaneous corneal perforation resulting in the need for urgent therapeutic intervention. A potential for severe ocular morbidity should be considered in all patients with this disorder despite a seemingly stable disease and appropriate gas permeable contact lens wear. Unilateral perforation cases should be watched closely for development of complications in the fellow eye.
Lee
William Barry
WB
Eye Consultants of Atlanta/Piedmont Hospital, 95 Collier Road, Suite 3000, Atlanta, GA 30309, USA. lee0003@aol.com
O'Halloran
Henry S
HS
Grossniklaus
Hans E
HE
D000328:Adult; D003261:Contact Lenses; D003316:Corneal Diseases / Q000209:etiology* / Q000628:therapy; D019781:Corneal Topography; D004108:Dilatation, Pathologic / Q000150:complications / Q000628:therapy; D005260:Female; D007839:Functional Laterality; D006801:Humans; D015948:Keratoplasty, Penetrating; D012422:Rupture, Spontaneous; D014014:Tissue Adhesives / Q000627:therapeutic use; D014792:Visual Acuity / Q000502:physiology
D014014:Tissue Adhesives
Cornea. 2003 Oct;22(7):705-6
14508268
Cornea. 2003 Mar;22(2):169-74
12605056
J Refract Surg. 2004 Mar-Apr;20(2):162-5
15072316
Ophthalmology. 2004 Jun;111(6):1102-7
15177959
Arch Ophthalmol. 1978 Jul;96(7):1217-21
352310
Ophthalmology. 2000 Oct;107(10):1836-40
11013182
Surv Ophthalmol. 1984 Jan-Feb;28(4):293-322
6230745
Can J Ophthalmol. 2006 Feb;41(1):74-7
16462877
J Cataract Refract Surg. 2001 Oct;27(10):1698-700
11687374
Cornea. 2007 Jun;26(5):625-8
17525665
Arch Ophthalmol. 1984 Jun;102(6):895-6
6610406
Trans Am Ophthalmol Soc. 1999;97:187-98; discussion 198-203
10703124
CLAO J. 1998 Jul;24(3):186-7
9684079
Am J Ophthalmol. 1989 Feb 15;107(2):167-70
2643881
Arch Ophthalmol. 1997 Feb;115(2):274-5
9046266
CLAO J. 2002 Jul;28(3):140-5
12144233
Exp Eye Res. 1996 Apr;62(4):325-7
8795451
Bibl Ophthalmol. 1957;12(47):672-7
13382796
Cornea. 1997 Mar;16(2):232-4
9071539
Ophthalmology. 1994 Oct;101(10):1738-44
7936572
Br J Ophthalmol. 1996 May;80(5):409-12
8695560
Cornea. 2005 Jul;24(5):555-60
15968160