title: Neocitreamicins I and II, novel antibiotics with activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci.
abstract: Two novel antibiotics, neocitreamicins I and II, were isolated from a fermentation broth of a Nocardia strain. This producing strain was obtained using an in situ diffusion chamber that facilitates the cultivation of soil microorganisms. The structures of neocitreamicins I and II were elucidated using UV, MS, and NMR data, and found to be related to the polycyclic xanthone antibiotics of the citreamicin class. The neocitreamicins showed in vitro activity against Gram-positive bacteria including strains of methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis.
authors.affiliation: NovoBiotic Pharmaceuticals, Cambridge, MA 02138, USA.
authors.forename: Aaron J
authors.initials: AJ
authors.lastname: Peoples
authors.forename: Qibo
authors.initials: Q
authors.lastname: Zhang
authors.forename: William P
authors.initials: WP
authors.lastname: Millett
authors.forename: Mithra T
authors.initials: MT
authors.lastname: Rothfeder
authors.forename: Brian C
authors.initials: BC
authors.lastname: Pescatore
authors.forename: Anne A
authors.initials: AA
authors.lastname: Madden
authors.forename: Losee L
authors.initials: LL
authors.lastname: Ling
authors.forename: Charles M
authors.initials: CM
authors.lastname: Moore
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D003470:Culture Media / Q000737:chemistry; D016983:Enterococcus / Q000187:drug effects*; D013058:Mass Spectrometry; D016106:Methicillin Resistance; D009615:Nocardia / Q000254:growth & development / Q000302:isolation & purification / Q000378:metabolism; D010080:Oxazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D012988:Soil Microbiology; D013057:Spectrum Analysis; D013211:Staphylococcus aureus / Q000187:drug effects*; D020713:Vancomycin Resistance
chemical_list: D000900:Anti-Bacterial Agents; D003470:Culture Media; D010080:Oxazoles
references.citation: J Antibiot (Tokyo). 1990 May;43(5):504-12
references.pmid: 2358403
references.citation: J Antibiot (Tokyo). 1982 Jun;35(6):645-52
references.pmid: 7150415
references.citation: J Antibiot (Tokyo). 1989 Jun;42(6):846-51
references.pmid: 2661510
references.citation: Science. 2002 May 10;296(5570):1127-9
references.pmid: 12004133
references.citation: J Antibiot (Tokyo). 1988 Apr;41(4):502-11
references.pmid: 3372357
references.citation: J Antibiot (Tokyo). 1991 Nov;44(11):1247-51
references.pmid: 1761421
references.citation: J Microbiol Methods. 2003 Dec;55(3):541-55
references.pmid: 14607398