title: Molecular profiling of uterine cervix carcinoma: an overview with a special focus on rationally designed target-based anticancer agents.
abstract: Although conventional multimodality approaches allowed improvement in the prognosis of patients with cervix cancer, several tumors do not respond similarly to standard approaches. Recent advances in basic research and genomics have improved our understanding of the biologic basis of the tumor development and progression. Tumor profiling allows for more selective therapeutic strategies leading to the identification of biomarkers or indicators of treatment response and to increased clinical efficacy through development of targeted therapies. Several markers have been identified, that are involved in cellular proliferation, interaction with angiogenesis, extracellular matrice adhesion/invasion, apoptosis, cell cycle pathways and DNA repair mechanisms. In this report, molecular profiling of uterine cervix carcinoma were reviewed with a special focus on rationally designed target-based anticancer agents, in order to clarify and to summary the present state of art in these particular promising area in cervix cancer management.
authors.affiliation: Department of Radiotherapy, Institut Gustave-Roussy, Villejuif, France. nicolas.magne@igr.fr
authors.forename: Nicolas
authors.initials: N
authors.lastname: Magné
authors.forename: Cyrus
authors.initials: C
authors.lastname: Chargari
authors.forename: Eric
authors.initials: E
authors.lastname: Deutsch
authors.forename: Pierre
authors.initials: P
authors.lastname: Castadot
authors.forename: Mitra
authors.initials: M
authors.lastname: Ghalibafian
authors.forename: Jean
authors.initials: J
authors.lastname: Bourhis
authors.forename: Christine
authors.initials: C
authors.lastname: Haie-Meder
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D014408:Biomarkers, Tumor; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D014594:Uterine Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor