Functional analysis of the SUMOylation pathway in Drosophila.
SUMOylation, a reversible process used as a 'fine-tuning' mechanism to regulate the role of multiple proteins, is conserved throughout evolution. This post-translational modification affects several cellular processes by the modulation of subcellular localization, activity or stability of a variety of substrates. A growing number of proteins have been identified as targets for SUMOylation, although, for many of them, the role of SUMO conjugation on their function is unknown. The use of model systems might facilitate the study of SUMOylation implications in vivo. In the present paper, we have compiled what is known about SUMOylation in Drosophila melanogaster, where the use of genetics provides new insights on SUMOylation's biological roles.
Talamillo
Ana
A
Functional Genomics Unit, CIC bioGUNE, Technology Park, Building 801-A, 48160 Derio, Bizkaia, Spain.
Sánchez
Jonatan
J
Barrio
Rosa
R
D000818:Animals; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000033:anatomy & histology / Q000196:embryology / Q000235:genetics / Q000378:metabolism*; D007107:Immune System / Q000502:physiology; D009024:Morphogenesis; D009424:Nervous System Physiological Phenomena; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction / Q000502:physiology*; D025841:Small Ubiquitin-Related Modifier Proteins / Q000235:genetics / Q000378:metabolism*
D029721:Drosophila Proteins; D025841:Small Ubiquitin-Related Modifier Proteins