HLA-DRB1 polymorphisms distribution in chronic dysimmune polyneuropathy.
The frequency of HLA-DRB1*15 polymorphism, which is strongly associated to multiple sclerosis, was investigated in 84 adult patients with chronic dysimmune polyneuropathy and 272 healthy controls. No significant differences were detected between cases and controls and, among patients, according to gender, peripheral nerve antigen antibody seropositivity, and electrophysiological features. A trend towards an increase of HLA-DRB1*11 in anti-MAG neuropathy was detected.
Gironi
M
M
Department of Neurology, Don C. Gnocchi Foundation IRCCS, S. Maria Nascente, University of Milan, and Department of Biomedical Sciences and Technologies, Don Gnocchi Foundation, San Giuseppe Hospital, Via Capecelatro 66, Milan, Italy. mgironi@dongnocchi.it
Guerini
F R
FR
Beghi
E
E
Antonini
G
G
Martinelli-Boneschi
F
F
Ceresa
L
L
Morino
S
S
Agliardi
C
C
Ferrante
P
P
Nemni
R
R
D000368:Aged; D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006684:HLA-DR Antigens / Q000235:genetics* / Q000378:metabolism; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011115:Polyneuropathies / Q000235:genetics* / Q000378:metabolism / Q000473:pathology
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains