6-Aryl- and 6-heteroarylpurines via cyclotrimerization.
Transition metal complex catalysed cocyclotrimerization of 6-alkynylpurines 1 with various diynes 2 and 6-(diynyl)purines 4 with nitriles 5 enabled to synthesize series of substituted 6-arylpurines 3 and 6-heteroarylpurines 6 in good yields. The obtained 6-aryl- and 6-heteroarylpurines were tested for cytostatic activity.
Turek
Pavel
P
Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 166 10 Prague 6, Czech Republic. pavel.turek@uochb.cas.cz
Hocek
Michal
M
Kotora
Martin
M
D000818:Animals; D002460:Cell Line; D045744:Cell Line, Tumor; D003035:Cobalt / Q000737:chemistry; D054697:Cytostatic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D053280:Diynes / Q000737:chemistry; D006801:Humans; D051379:Mice; D009570:Nitriles / Q000737:chemistry; D011687:Purines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D054697:Cytostatic Agents; D053280:Diynes; D009570:Nitriles; D011687:Purines; D003035:Cobalt