title: Microbiology. Desperately seeking new antibiotics.
authors.affiliation: Antibacterial Disease Performance Unit, Infectious Diseases Center of Excellence, GlaxoSmithKline, Collegeville, PA 19426, USA. david.j.payne@gsk.com
authors.forename: David J
authors.initials: DJ
authors.lastname: Payne
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D001424:Bacterial Infections / Q000188:drug therapy* / Q000517:prevention & control; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D003598:Cytoskeletal Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015195:Drug Design; D024881:Drug Resistance, Bacterial; D029968:Escherichia coli Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects; D000071677:Histidine Kinase; D006801:Humans; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D011494:Protein Kinases / Q000378:metabolism*; D011725:Pyridines / Q000378:metabolism / Q000494:pharmacology*; D013449:Sulfonamides / Q000494:pharmacology / Q000627:therapeutic use; D013844:Thiazoles / Q000378:metabolism / Q000494:pharmacology*; D014774:Virulence / Q000235:genetics; D037521:Virulence Factors / Q000037:antagonists & inhibitors / Q000378:metabolism; D024482:Vitamin K 2 / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D003598:Cytoskeletal Proteins; D029968:Escherichia coli Proteins; C071525:FtsZ protein, Bacteria; C531088:LED209; C531944:PC190723; D047428:Protein Kinase Inhibitors; D011725:Pyridines; C455504:QseC protein, E coli; D013449:Sulfonamides; D013844:Thiazoles; D037521:Virulence Factors; D024482:Vitamin K 2; D011494:Protein Kinases; D000071677:Histidine Kinase