The usefulness of circulating adipokine levels for the assessment of obesity-related health problems.
Because the prevalence of obesity has increased dramatically in recent years, one of the key targets of public health is obesity and its associated pathological conditions. Obesity occurs as a result of white adipose tissue enlargement, caused by adipocyte hyperplasia and/or hypertrophy. Recently, endocrine aspects of adipose tissue have become an active research area and these adipose tissue-derived factors are referred to as adipokines. These adipokines interact with a range of processes in many different organ systems and influence a various systemic phenomena. Therefore, dysregulated production of adipokines has been found to participate in the development of metabolic and vascular diseases related to obesity. The obese state is also known to be associated with increased local and systemic inflammation. Adipokines influence not only systemic insulin resistance and have pathophysiological roles in the metabolic syndrome and cardiovascular disease, but also contribute toward an increase in local and systemic inflammation. Thus, circulating levels of adipokines can be used as high-throughput biomarkers to assess the obesity-related health problems, including low grade inflammation. This review focuses on the usefulness of measuring circulating adipokine levels for the assessment of obesity-related health problems.
Inadera
Hidekuni
H
Department of Public Health, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. inadera@med.u-toyama.ac.jp
D054392:Adipokines / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D016207:Cytokines / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D024821:Metabolic Syndrome / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D009765:Obesity / Q000097:blood* / Q000150:complications*; D011237:Predictive Value of Tests
D054392:Adipokines; D015415:Biomarkers; D016207:Cytokines
J Clin Endocrinol Metab. 2002 Jun;87(6):2764-9
12050247
Diabet Med. 2003 Oct;20(10):828-31
14510864
Diabetes. 2004 Mar;53(3):585-90
14988241
J Clin Endocrinol Metab. 2005 Oct;90(10):5677-83
16076942
Diabetologia. 2003 May;46(5):625-33
12739017
Diabetes. 2006 Apr;55(4):1133-40
16567539
Diabetologia. 1991 Jun;34(6):416-22
1884900
Am J Epidemiol. 2007 Jan 15;165(2):164-74
17101706
J Clin Endocrinol Metab. 2005 Oct;90(10):5834-40
16091493
Biochem Biophys Res Commun. 1999 Apr 2;257(1):79-83
10092513
Arterioscler Thromb Vasc Biol. 2006 Apr;26(4):871-6
16456090
Nature. 2006 Dec 14;444(7121):860-7
17167474
Hypertension. 2004 Jun;43(6):1318-23
15123570
Diabetologia. 1998 Oct;41(10):1241-8
9794114
JAMA. 2004 Apr 14;291(14):1730-7
15082700
Circ Res. 2005 May 13;96(9):939-49
15890981
J Clin Endocrinol Metab. 2005 Jul;90(7):4170-6
15827100
Nephrol Dial Transplant. 2002 Mar;17(3):435-41
11865089
Diabetes Care. 2004 Oct;27(10):2450-7
15451915
Arterioscler Thromb Vasc Biol. 2001 Jun;21(6):961-7
11397704
Diabetes Care. 2003 Jul;26(7):2015-20
12832305
Am J Physiol Endocrinol Metab. 2003 Sep;285(3):E527-33
12736161
Obes Res. 2002 Jan;10(1):1-5
11786595
J Interferon Cytokine Res. 1999 Oct;19(10):1179-82
10547158
J Clin Endocrinol Metab. 2007 Jul;92(7):2590-7
17595259
Diabetes Care. 2006 Jun;29(6):1357-62
16732021
Circulation. 2005 Feb 22;111(7):932-9
15710760
FASEB J. 2005 Sep;19(11):1540-2
15985526
J Clin Endocrinol Metab. 2007 Dec;92(12):4883-8
17986645
Arterioscler Thromb Vasc Biol. 1998 Aug;18(8):1199-202
9714125
Arterioscler Thromb Vasc Biol. 2002 Oct 1;22(10):1668-73
12377747
J Clin Endocrinol Metab. 2007 Aug;92(8):3224-9
17550959
Eur Heart J. 2008 May;29(10):1307-15
18390868
J Clin Endocrinol Metab. 2008 Apr;93(4):1489-96
18211973
J Clin Endocrinol Metab. 2004 Apr;89(4):1844-8
15070954
J Clin Endocrinol Metab. 2004 Jan;89(1):150-6
14715842
Circulation. 2005 Sep 20;112(12):1756-62
16157772
Curr Drug Targets. 2003 Aug;4(6):487-92
12866663
Arterioscler Thromb Vasc Biol. 1998 Nov;18(11):1716-22
9812909
Nature. 2006 Dec 14;444(7121):875-80
17167476
Int J Obes (Lond). 2005 Jun;29(6):624-31
15824752
Horm Metab Res. 2004 Oct;36(10):721-7
15523599
J Clin Endocrinol Metab. 2002 Oct;87(10):4602-6
12364441
FASEB J. 2002 Sep;16(11):1335-47
12205025
Obes Res. 2003 Mar;11(3):368-72
12634431
Atherosclerosis. 2009 Mar;203(1):277-83
18656877
J Clin Endocrinol Metab. 2003 Jul;88(7):3236-40
12843170
Circulation. 2002 Dec 3;106(23):2908-12
12460870
J Clin Endocrinol Metab. 2007 May;92(5):1886-90
17299074
Diabetes. 2002 Jun;51(6):1884-8
12031977
J Clin Endocrinol Metab. 2004 Jun;89(6):2665-71
15181039
Thromb Haemost. 1989 Jun 30;61(3):370-3
2678583
Arch Intern Med. 2007 Jul 23;167(14):1510-7
17646605
Int J Obes Relat Metab Disord. 2004 Aug;28(8):993-7
15211360
Diabetes. 2002 May;51(5):1596-600
11978661
J Clin Endocrinol Metab. 2007 Aug;92(8):2944-51
17504892
Diabetes. 2005 Jul;54(7):2003-11
15983200
Horm Metab Res. 1997 Mar;29(3):111-4
9137980
Circulation. 2003 Feb 11;107(5):671-4
12578865
Clin Chim Acta. 2004 Jan;339(1-2):57-63
14687894
Circulation. 2002 Nov 26;106(22):2767-70
12451000
Diabetes. 2005 Aug;54(8):2277-86
16046292
J Biol Chem. 2003 Mar 14;278(11):9073-85
12496257
Heart. 2004 May;90(5):528-33
15084551
J Clin Endocrinol Metab. 2007 Jul;92(7):2764-72
17456573
J Clin Endocrinol Metab. 2006 Mar;91(3):1042-7
16394095
Circulation. 2003 Jan 28;107(3):391-7
12551861
Thromb Haemost. 1992 Oct 5;68(4):396-9
1448769
Arterioscler Thromb Vasc Biol. 2001 Jun;21(6):968-70
11397705
Diabetologia. 2004 Jun;47(6):1029-37
15168015
Diabetologia. 2007 Apr;50(4):814-23
17294166
N Engl J Med. 2007 Jan 18;356(3):213-5
17229948
Int J Obes Relat Metab Disord. 2004 Jun;28(6):783-9
15024400
Am J Cardiol. 2000 Mar 15;85(6):777-9, A9
12000061
Diabet Med. 1999 Mar;16(3):207-11
10227565
Clin Chim Acta. 2006 Feb;364(1-2):251-5
16111669
Diabet Med. 2004 May;21(5):497-9
15089799
Clin Lab. 2003;49(11-12):571-6
14651328
Diabetes Care. 2004 Jan;27(1):47-52
14693965
J Clin Invest. 2003 Dec;112(12):1821-30
14679177
J Am Coll Cardiol. 2003 Apr 16;41(8):1408-13
12706940
Lancet. 2003 Jan 18;361(9353):226-8
12547549
Horm Metab Res. 2002 Nov-Dec;34(11-12):671-3
12660880
Ann Rheum Dis. 2007 Apr;66(4):458-63
17040961
Atherosclerosis. 2006 Jun;186(2):411-9
16140306
N Engl J Med. 2006 Jun 15;354(24):2601-10
16775242
Circulation. 2002 Feb 5;105(5):564-9
11827920
Metabolism. 2005 Mar;54(3):330-4
15736110
Horm Metab Res. 1996 Dec;28(12):737-43
9013754
Int J Obes Relat Metab Disord. 1999 Apr;23(4):355-60
10340812
J Clin Endocrinol Metab. 2007 Mar;92(3):1168-71
17164313
Diabetes. 1994 Jan;43(1):104-9
8262307
J Clin Endocrinol Metab. 1999 Jan;84(1):272-8
9920095
J Clin Endocrinol Metab. 2007 Jul;92(7):2712-9
17440021
Diabetes. 1997 May;46(5):860-7
9133556
Diabetes Care. 2003 Oct;26(10):2883-9
14514596
Circulation. 2002 Feb 19;105(7):804-9
11854119
Arterioscler Thromb Vasc Biol. 2003 Jun 1;23(6):1042-7
12714437
Am J Physiol Endocrinol Metab. 2006 Oct;291(4):E843-8
16757549
Circulation. 2001 Nov 13;104(20):2395-400
11705814
Diabetes. 2004 May;53(5):1279-84
15111497
Nature. 2005 Jul 21;436(7049):356-62
16034410
Obes Surg. 2006 Jun;16(6):709-15
16756729
Int J Obes (Lond). 2005 Jan;29(1):146-50
15520826
J Clin Endocrinol Metab. 2007 May;92(5):1971-4
17341558
Diabetes Care. 2007 Jul;30(7):1802-6
17416795
J Clin Endocrinol Metab. 1998 Mar;83(3):859-62
9506740
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2003 Nov;147(1):63-9
15034607
Am J Physiol Endocrinol Metab. 2001 May;280(5):E745-51
11287357
J Am Coll Cardiol. 2005 Jul 19;46(2):379-80
16022972
Int J Cardiol. 2005 Jun 8;101(3):385-90
15907405
Diabetes. 2004 Sep;53(9):2473-8
15331562
Atherosclerosis. 2000 Feb;148(2):209-14
10657556
J Biol Chem. 1992 Jan 25;267(3):1805-10
1370481
Int J Obes Relat Metab Disord. 2004 Nov;28(11):1357-64
15356668
Diabetes Care. 2003 Dec;26(12):3226-9
14633806
Science. 1993 Jan 1;259(5091):87-91
7678183
Diabetes. 2006 Oct;55(10):2805-10
17003346
N Engl J Med. 2006 Sep 28;355(13):1393-4; author reply 1394-5
17014043
Obes Res. 2003 Aug;11(8):997-1001
12917505
J Clin Endocrinol Metab. 1997 Dec;82(12):4196-200
9398739
J Clin Endocrinol Metab. 2004 Aug;89(8):4053-61
15292348
Diabetologia. 1998 Jul;41(7):860-1
9686931
J Clin Endocrinol Metab. 2006 Nov;91(11):4415-23
16926246
Circulation. 1999 Dec 21-28;100(25):2473-6
10604883
Clin Chim Acta. 2004 Jun;344(1-2):1-12
15149866
J Am Coll Cardiol. 2005 Sep 20;46(6):1112-3
16168299
Arterioscler Thromb Vasc Biol. 1999 Apr;19(4):972-8
10195925
Arterioscler Thromb Vasc Biol. 2005 Mar;25(3):e15-6
15731480
Lancet. 2002 Jul 6;360(9326):57-8
12114044
Eur J Endocrinol. 2003 Oct;149(4):331-5
14514348
Am J Physiol Endocrinol Metab. 2006 Feb;290(2):E326-33
16144822
J Clin Endocrinol Metab. 2005 Aug;90(8):4792-6
15928248
Diabetes Care. 2007 May;30(5):1173-8
17259477
Eur Heart J. 2005 Aug;26(16):1640-6
15932907
J Clin Endocrinol Metab. 2003 Oct;88(10):4848-56
14557464
Nature. 1994 Dec 1;372(6505):425-32
7984236
J Clin Endocrinol Metab. 2001 Mar;86(3):1267-73
11238519
J Clin Endocrinol Metab. 2007 Dec;92(12):4569-74
17911172
N Engl J Med. 2006 Sep 28;355(13):1392; author reply 1394-5
17005964
N Engl J Med. 2006 Jun 15;354(24):2552-63
16775236
Hypertension. 2003 Sep;42(3):231-4
12860835
Mol Cell Endocrinol. 2001 Apr 25;175(1-2):81-92
11325518
J Clin Endocrinol Metab. 2001 May;86(5):1930-5
11344187
Circulation. 2004 Dec 21;110(25):3842-8
15596567
Diabetes. 2006 Jul;55(7):1954-60
16804063
Cytokine. 2006 Sep;35(5-6):247-52
17079158
JAMA. 2003 Apr 9;289(14):1799-804
12684358
Arterioscler Thromb Vasc Biol. 2003 Jan 1;23(1):85-9
12524229
Nat Med. 2001 Aug;7(8):947-53
11479628
J Clin Endocrinol Metab. 2007 Dec;92(12):4827-34
17878249
J Clin Endocrinol Metab. 2001 Aug;86(8):3815-9
11502817
Diabetes. 2001 May;50(5):1126-33
11334417
Nat Med. 2002 Nov;8(11):1288-95
12368907
Arterioscler Thromb Vasc Biol. 2000 Jun;20(6):1595-9
10845877
J Clin Endocrinol Metab. 2004 Jun;89(6):2697-703
15181044
Am J Physiol Heart Circ Physiol. 2007 Apr;292(4):H1655-63
17142348
Diabetes. 2003 Feb;52(2):239-43
12540592
J Clin Endocrinol Metab. 2006 Dec;91(12):5044-50
16984981
Obes Res. 2005 Oct;13(10):1764-71
16286524
J Clin Endocrinol Metab. 2003 Nov;88(11):5452-5
14602788
Int J Obes (Lond). 2006 Sep;30(9):1347-55
16534530
Diabetologia. 2003 Nov;46(11):1483-8
14534780
Biochem Biophys Res Commun. 1996 Apr 16;221(2):286-9
8619847
Int J Obes (Lond). 2005 Nov;29(11):1308-14
15953938
Diabetologia. 2005 Jun;48(6):1084-7
15902402
Diabetologia. 2003 Apr;46(4):459-69
12687327
J Clin Endocrinol Metab. 2006 Nov;91(11):4277-86
16912132
Eur Heart J. 2006 Oct;27(19):2300-9
16864609
J Clin Endocrinol Metab. 2007 Nov;92(11):4313-8
17698903
Diabetes Care. 2007 May;30(5):1168-72
17337499
J Biol Chem. 1996 May 3;271(18):10697-703
8631877
Diabetes. 1988 Dec;37(12):1595-607
3056758
Br J Plast Surg. 2004 Apr;57(3):190-4
15006519
Diabetes. 2006 May;55(5):1337-41
16644690
Diabetologia. 1998 Jan;41(1):65-71
9498632
Obes Res. 2001 Jul;9(7):414-7
11445664
Circulation. 2003 Feb 11;107(5):690-5
12578870
Immunol Res. 2001;24(2):163-76
11594454
Am J Epidemiol. 1983 Jan;117(1):19-26
6823949
Diabetes Care. 2006 Nov;29(11):2457-61
17065684
Lancet. 1991 Aug 24;338(8765):515-6
1678476
Arterioscler Thromb Vasc Biol. 1999 Aug;19(8):1986-91
10446082
J Clin Endocrinol Metab. 2003 Apr;88(4):1730-6
12679465
Obesity (Silver Spring). 2007 Sep;15(9):2225-32
17890490
Acta Obstet Gynecol Scand. 2004 Apr;83(4):341-7
15005780
J Clin Invest. 2003 Dec;112(12):1796-808
14679176
Int J Obes (Lond). 2005 Nov;29(11):1315-20
16044175
J Clin Endocrinol Metab. 2000 Sep;85(9):3338-42
10999830
Clin Exp Immunol. 2000 Sep;121(3):437-43
10971508
J Clin Endocrinol Metab. 2004 Jun;89(6):2548-56
15181022
Arterioscler Thromb Vasc Biol. 1998 Jan;18(1):1-6
9445248
J Clin Endocrinol Metab. 2002 Oct;87(10):4652-6
12364452
Horm Metab Res. 2001 Oct;33(10):602-7
11607880
JAMA. 1999 Dec 8;282(22):2131-5
10591334
J Clin Endocrinol Metab. 2006 Sep;91(9):3418-25
16804048
N Engl J Med. 1985 Dec 19;313(25):1557-63
3934538
Eur J Endocrinol. 2005 Jul;153(1):91-8
15994750
Diabetes. 2001 Oct;50(10):2199-202
11574398
Endocr Rev. 2006 Dec;27(7):762-78
17056740
Nature. 2001 Jan 18;409(6818):307-12
11201732
Heart. 2006 Oct;92(10):1420-4
16621874
Diabetologia. 2007 Sep;50(9):1930-1937
17639305
Obes Res. 2003 Sep;11(9):1048-54
12972674
J Clin Endocrinol Metab. 2007 Jun;92(6):2330-5
17405846