The nuclear receptor tailless is required for neurogenesis in the adult subventricular zone.
The tailless (Tlx) gene encodes an orphan nuclear receptor that is expressed by neural stem/progenitor cells in the adult brain of the subventricular zone (SVZ) and the dentate gyrus (DG). The function of Tlx in neural stem cells of the adult SVZ remains largely unknown. We show here that in the SVZ of the adult brain Tlx is exclusively expressed in astrocyte-like B cells. An inducible mutation of the Tlx gene in the adult brain leads to complete loss of SVZ neurogenesis. Furthermore, analysis indicates that Tlx is required for the transition from radial glial cells to astrocyte-like neural stem cells. These findings demonstrate the crucial role of Tlx in the generation and maintenance of NSCs in the adult SVZ in vivo.
Liu
Hai-Kun
HK
Division of Molecular Biology of the Cell I, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Belz
Thorsten
T
Bock
Dagmar
D
Takacs
Andrea
A
Wu
Hui
H
Lichter
Peter
P
Chai
Minqiang
M
Schütz
Günther
G
D000818:Animals; D002552:Cerebral Ventricles / Q000166:cytology*; D051379:Mice; D039902:Multipotent Stem Cells / Q000166:cytology; D009474:Neurons / Q000166:cytology*; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000502:physiology*
C490258:Nr2e1 protein, mouse; D018160:Receptors, Cytoplasmic and Nuclear
Nature. 2004 Jan 1;427(6969):78-83
14702088
Curr Top Dev Biol. 2005;69:67-99
16243597
J Neurosci. 1997 Jul 1;17(13):5046-61
9185542
Nature. 1997 Dec 4;390(6659):515-7
9394001
Nature. 2008 Feb 21;451(7181):1004-7
18235445
Development. 1995 Mar;121(3):839-53
7720587
Trends Neurosci. 2003 Mar;26(3):125-31
12591214
Neuron. 2006 Jul 20;51(2):187-99
16846854
Nat Neurosci. 2003 Nov;6(11):1127-34
14583753
Nat Neurosci. 2004 Nov;7(11):1233-41
15494728
Science. 2000 Feb 25;287(5457):1433-8
10688783
Science. 2007 Mar 2;315(5816):1243-9
17303719
Nat Neurosci. 2005 Jul;8(7):865-72
15951811
J Neurosci. 2002 Jan 15;22(2):437-45
11784788
Curr Opin Cell Biol. 2006 Dec;18(6):704-9
17046226
Cell Prolif. 1994 May;27(5):279-89
10465012
Neuron. 2004 Mar 25;41(6):881-90
15046721
Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):111-6
16373498
J Neurosci. 2002 Feb 1;22(3):629-34
11826091
Eur J Neurosci. 2007 Oct;26(8):2222-7
17953618
Neuron. 2002 Dec 19;36(6):1021-34
12495619
Genesis. 2000 Nov-Dec;28(3-4):147-55
11105057
J Dent Res. 1981 Aug;60 Spec No C:1611-20
6943171
Genes Dev. 2006 May 15;20(10):1308-20
16702404
Cell. 1999 Jan 8;96(1):25-34
9989494
Nat Genet. 1999 Jan;21(1):70-1
9916792
Cell. 1999 Jun 11;97(6):703-16
10380923
J Neurosci. 2004 Sep 22;24(38):8333-45
15385616
Science. 2007 Jul 20;317(5836):381-4
17615304
J Neurosci. 2007 Apr 18;27(16):4297-302
17442813
Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17528-32
15574494