title: One-pot synthesis of antiviral acyclovir and other nucleosides derivatives using doped natural phosphate as lewis acid catalyst.
abstract: Natural phosphate doped with iodine or potassium iodide is an active catalyst for the one-pot synthesis of acyclonucleosides. To demonstrate the utility of the new catalyst system, the highly important antiviral drug acyclovir was directly and regioselectively obtained from NAcG with no byproducts.
authors.affiliation: Faculty of Science Semlalia, Unité de Chimie Biomoléculaire et Médicinale, Marrakech, Morocco. hblazrek50@gmail.com
authors.forename: Hassan B
authors.initials: HB
authors.lastname: Lazrek
authors.forename: Laila
authors.initials: L
authors.lastname: Baddi
authors.forename: Michael
authors.initials: M
authors.lastname: Smietana
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Vasseur
authors.forename: Said
authors.initials: S
authors.lastname: Sebti
authors.forename: Mohamed
authors.initials: M
authors.lastname: Zahouily
mesh_terms: D000212:Acyclovir / Q000138:chemical synthesis*; D000998:Antiviral Agents / Q000138:chemical synthesis*; D002384:Catalysis; D007455:Iodine / Q000737:chemistry; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis*; D010710:Phosphates / Q000737:chemistry*
chemical_list: D000998:Antiviral Agents; D009705:Nucleosides; D010710:Phosphates; D007455:Iodine; D000212:Acyclovir