title: The effect of virus dose on the development of Marek's disease in two strains of chickens.
abstract: The effect of inoculating different doses of Marek's disease virus on the consequent lymphocyte-associated viraemia titres, survival time and mortality was studied in two strains of chickens, one highly susceptible (a strain of Rhode Island Red) and one moderately resistant (a strain of Light Sussex) to Marek's disease. In both strains an increase in the infecting dose of virus increased the ensuing viraemia, and there was an inverse relationship between virus dose and survival time. There was a negative correlation between viraemia titres and survival time. The modulation of infecting dose had no effect on overall mortality among the susceptible, Rhode Island Red strain, chickens, but did influence the mortality of the Light Sussex strain chickens. It was suggested that the outcome of infection within an individual may be determined by a rather subtle interaction between the infection and transformation of a limiting number of target cells and an immune response directed against such infected or transformed cells, and that in different breeds of chickens these two factors may differ in importance.
authors.affiliation: Houghton Poultry Research Station, Houghton Huntingdon, Cambs., England.
authors.forename: P C
authors.initials: PC
authors.lastname: Powell
authors.forename: A M
authors.initials: AM
authors.lastname: Lawn
authors.forename: L N
authors.initials: LN
authors.lastname: Payne
authors.forename: M
authors.initials: M
authors.lastname: Rennie
authors.forename: L J
authors.initials: LJ
authors.lastname: Ross