Triazole oxytocin antagonists: identification of aryl ether replacements for a biaryl substituent.
Several potent aryl ether/triazole oxytocin antagonists are described. The lead compound in this series had significantly improved aqueous solubility over related systems containing a biaryl substituent.
Brown
Alan
A
Discovery Chemistry, Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK. Alan.D.Brown@pfizer.com
Brown
Lindsay
L
Brown
T Bruce
TB
Calabrese
Andrew
A
Ellis
Dave
D
Puhalo
Nicholas
N
Smith
Chris R
CR
Wallace
Olga
O
Watson
Lesa
L
D000284:Administration, Oral; D000818:Animals; D015394:Molecular Structure; D010121:Oxytocin / Q000037:antagonists & inhibitors*; D051381:Rats; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D014230:Triazoles; D010121:Oxytocin