Synthesis of (-)-hamigeran B.
The synthesis of (-)-hamigeran B has been achieved, based on a new approach to cyclopentane construction, the rhodium-mediated intramolecular C-H insertion of alpha-aryl-alpha-diazoketones. The endo-isopropyl group was installed by selective hydrogenation of a cyclopropylidene substituent.
Taber
Douglass F
DF
Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA. taberdf@udel.edu
Tian
Weiwei
W
D003517:Cyclopentanes / Q000737:chemistry; D006865:Hydrogenation; D007659:Ketones / Q000737:chemistry; D009285:Naphthoquinones / Q000138:chemical synthesis*; D012238:Rhodium / Q000737:chemistry; D013237:Stereoisomerism
D003517:Cyclopentanes; D007659:Ketones; D009285:Naphthoquinones; C483756:hamigeran B; D012238:Rhodium
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