[Short stature in chronic kidney disease: physiopathology and treatment with growth hormone].
Growth failure is frequent and a clinically important issue in children with chronic kidney disease (CKD). Many factors contribute to impaired growth in these children, including abnormalities in the growth hormone (GH)--insulin-like growth factor 1 (IGF-1) axis, malnutrition, acidosis, renal bone disease and glucocorticoid associated treatment. The management of growth failure in children with CKD is complicated by the presence of other-disease related complications requiring medical intervention. Despite evidence of GH efficacy and safety in this population, this therapy is still underutilized. This review shows the impact, the causes and the treatment of growth failure in children with CKD.
Oliveira
Josenilson Campos de
JC
Clínica Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brazil.
Siviero-Miachon
Adriana A
AA
Spinola-Castro
Angela Maria
AM
Belangero
Vera Maria Santoro
VM
Guerra-Junior
Gil
G
D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D001827:Body Height / Q000187:drug effects; D006130:Growth Disorders / Q000188:drug therapy* / Q000503:physiopathology; D019382:Human Growth Hormone / Q000378:metabolism / Q000627:therapeutic use*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007676:Kidney Failure, Chronic / Q000150:complications*
D000305:Adrenal Cortex Hormones; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I