[Preparation and dissolution in vitro of esomeprazole zinc solid dispersion].
OBJECTIVE
To prepare esomeprazole zinc solid dispersion (EZSD) to improve its dissolution in vitro.


METHODS
EZ solid dispersions were prepared by solvent method using PVP K30 and PEG 6000 as carriers. The in vitro dissolution of the EZ solid dispersions enteric capsules was analyzed. The existence status of EZ in the carrier was determined by differential scanning calorimeter (DSC).


RESULTS
The dissolution of EZ increased first and then decreased with the increase of the ratio of carries. The dissolution of the solid dispersions with PEG 6000 as carrier was faster than that with PVP K30 as carrier. The EZ was amorphously dispersed in the solid dispersion.


CONCLUSIONS
The in vitro dissolution rate of EZ is significantly improved by the solid dispersion.
Xie
Ping
P
Institute of Chemical Engineering, Sichuan University, Chengdu 610065, China.
Xie
Yong-mei
YM
Song
Hang
H
Song
Xin
X
Zuo
Yuan-jie
YJ
Qiu
Yu
Y
Tang
Xiao-hai
XH
D004337:Drug Carriers; D064098:Esomeprazole / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D011205:Povidone / Q000737:chemistry; D054328:Proton Pump Inhibitors / Q000138:chemical synthesis / Q000737:chemistry*; D012995:Solubility; D015032:Zinc / Q000737:chemistry*
D004337:Drug Carriers; D054328:Proton Pump Inhibitors; D011092:Polyethylene Glycols; D011205:Povidone; D015032:Zinc; D064098:Esomeprazole