title: Hemodynamic performance of the Edwards Prima Plus stentless valve at 1 year.
abstract: OBJECTIVE
  The Edwards Prima Plus stentless valve bioprosthesis (EPPSV) is a porcine aortic root cylinder with resected coronary ostia, fixed in glutaraldehyde at low pressure, and chemically treated to prevent calcification. Utilization of this valve was approved in January 2005 in Japan. The purpose of this study was to evaluate the early hemodynamic performance of EPPSVs in our experience.
  
  
  METHODS
  From April 2005 to January 2006, a total of 21 patients underwent aortic valve replacement with EPPSVs. The hemodynamic performance of EPPSVs was evaluated at the time of discharge (2 weeks) and at 1 year by transthoracic two-dimensional Doppler echocardiography.
  
  
  RESULTS
  There was one non-valve-related early death and one non-valve-related late death. Hemodynamic data were available for comparison from the time of discharge and at 1 year postoperatively in 19 patients (mean valve size 22 +/- 1 mm). Hemodynamic follow-up showed a significant decrease in the peak and mean transvalvular pressure gradients at discharge (37 +/- 16 and 18 +/- 8 mmHg, respectively) and 1 year postoperatively (25 +/- 7 and 12 +/- 4 mmHg, respectively) (P < 0.01). The effective orifice area increased significantly between the time of discharge (1.31 +/- 0.31 cm2) and 1 year (1.57 +/- 0.37 cm2) (P < 0.05) postoperatively. The left ventricular mass index was significantly reduced from the time of discharge (167 +/- 49 g/m2) to 1 year postoperatively (126 +/- 47 g/m2) (P < 0.001).
  
  
  CONCLUSIONS
  EPPSVs have been associated with high early transprosthetic gradients. Such gradients tend to regress, with significant improvement at 1 year and concomitant regression of left ventricular hypertrophy.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Anjo Kosei Hospital, 28 Higashihirokute Anjo-cho, Anjo, Aichi 446-8602, Japan. keizo-5254r@yahoo.co.jp
authors.forename: Keizo
authors.initials: K
authors.lastname: Tanaka
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Kinoshita
authors.forename: Kazuya
authors.initials: K
authors.lastname: Fujinaga
authors.forename: Shinji
authors.initials: S
authors.lastname: Kanemitsu
authors.forename: Jin
authors.initials: J
authors.lastname: Tanaka
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Suzuki
authors.forename: Toshiya
authors.initials: T
authors.lastname: Tokui
mesh_terms: D000368:Aged; D000818:Animals; D001024:Aortic Valve Stenosis / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D001705:Bioprosthesis; D018618:Echocardiography, Doppler, Color; D005260:Female; D005500:Follow-Up Studies; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000295:instrumentation*; D006439:Hemodynamics; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery; D008297:Male; D011474:Prosthesis Design; D013318:Stroke Volume; D013552:Swine; D013997:Time Factors; D016896:Treatment Outcome; D016277:Ventricular Function, Left
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