Mouse model of relapse to the abuse of drugs: procedural considerations and characterizations.
To identify genetic risk factors involved in relapse to the abuse of drugs in humans, it is essential for researchers to develop a reliable mouse model of relapse by extending well-established extinction-reinstatement procedures in rats. Because of technical difficulties such as the relatively short duration of catheter patency in mice, few reports are available on the characterization of extinction-reinstatement behavior in wild-type and genetically engineered mutant mice. In this review, efforts are made to describe practical considerations during the establishment of extinction-reinstatement procedure in mice, including drug-primed, cue-induced, and stress-triggered reinstatement of previously extinguished drug-seeking behavior. Next, attention will be given to some characteristics of extinction-reinstatement behavior in mice. The present review might provide a new impetus in the exploration of genetic risk factors involved in relapse to drug dependence/addiction in humans using extinction-reinstatement procedures in widely available mutant mice.
Yan
Yijin
Y
Department of Neuropsychopharmacology & Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan.
Nabeshima
Toshitaka
T
D000818:Animals; D016739:Behavior, Addictive / Q000503:physiopathology / Q000523:psychology*; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D012008:Recurrence; D012054:Reinforcement, Psychology; D012646:Self Administration / Q000379:methods; D019966:Substance-Related Disorders / Q000503:physiopathology / Q000523:psychology*