title: Central neurocytoma: proton MR spectroscopy and diffusion weighted MR imaging findings.
abstract: OBJECTIVE
  To present proton magnetic resonance spectroscopy and diffusion-weighted imaging (DWI) findings of central neurocytoma (CN).
  
  
  METHODS
  Imaging findings of seven patients with the histopathological diagnosis of CN (five male and two female; age range, 21-28 years of age) were evaluated retrospectively. In addition to conventional magnetic resonance imaging features, we also assessed the metabolite ratios and tumor normalized apparent diffusion coefficient (NADC), which was calculated by dividing the tumor apparent diffusion coefficient (ADC) values by normal ADC. Approval from our institutional review board was obtained for this review.
  
  
  RESULTS
  The tumor choline/creatine ratios were 5.17+/-2.38, while N-acetyl aspartate/choline and N-acetyl aspartate/creatine ratios were 0.33+/-0.15 and 1.84+/-1.38, respectively. On DWI, tumors had heterogeneous hyperintense appearances when compared with the contralateral parietal lobe white matter and tumor NADC values were 0.63+/-0.05.
  
  
  CONCLUSIONS
  Significantly increased choline/creatine and decreased N-acetyl aspartate/choline ratios with lower NADC values in CN resemble high-grade gliomas and complicate the diagnosis. Familiarity its physiologic features would help to presurgical diagnosis of ventricular and exraventricular CNs.
authors.affiliation: Department of Radiology, Etlik, Ankara 06018, Turkey. kocaoglumurat@yahoo.com
authors.forename: Murat
authors.initials: M
authors.lastname: Kocaoglu
authors.forename: Fatih
authors.initials: F
authors.lastname: Ors
authors.forename: Nail
authors.initials: N
authors.lastname: Bulakbasi
authors.forename: Onder
authors.initials: O
authors.lastname: Onguru
authors.forename: Cuneyt
authors.initials: C
authors.lastname: Ulutin
authors.forename: Halil Ibrahim
authors.initials: HI
authors.lastname: Secer
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D011522:Protons; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D011522:Protons