title: A new family of small (4kDa) neurotoxins from the venoms of spiders of the genus Phoneutria.
abstract: A family of 4kDa neurotoxic peptides was purified from venoms of Phoneutria spiders. All have six cysteine residues, and low similarity with other neurotoxins. Three toxins caused moderate inhibition of L-type Ca(2+) channels. The structure of toxin PRTx27C3 was modeled and compared with toxin ADO1. The importance of four residues is suggested.
authors.affiliation: Dept. of Biochemistry and Immunology; Instituto de Ciências Biológicas, Brazil.
authors.forename: A D
authors.initials: AD
authors.lastname: Lúcio
authors.forename: F V
authors.initials: FV
authors.lastname: Campos
authors.forename: M
authors.initials: M
authors.lastname: Richardson
authors.forename: M N
authors.initials: MN
authors.lastname: Cordeiro
authors.forename: M S C
authors.initials: MS
authors.lastname: Mazzoni
authors.forename: M E
authors.initials: ME
authors.lastname: de Lima
authors.forename: M C
authors.initials: MC
authors.lastname: Pimenta
authors.forename: M P
authors.initials: MP
authors.lastname: Bemquerer
authors.forename: S G
authors.initials: SG
authors.lastname: Figueiredo
authors.forename: P C
authors.initials: PC
authors.lastname: Gomes
authors.forename: P S L
authors.initials: PS
authors.lastname: Beirão
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002121:Calcium Channel Blockers / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D020746:Calcium Channels, L-Type / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D051379:Mice; D008958:Models, Molecular; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009498:Neurotoxins / Q000737:chemistry* / Q000235:genetics / Q000302:isolation & purification / Q000633:toxicity; D011487:Protein Conformation; D017386:Sequence Homology, Amino Acid; D021241:Spectrometry, Mass, Electrospray Ionization; D013111:Spider Venoms / Q000737:chemistry* / Q000235:genetics / Q000302:isolation & purification / Q000633:toxicity; D013112:Spiders / Q000737:chemistry* / Q000235:genetics
chemical_list: D002121:Calcium Channel Blockers; D020746:Calcium Channels, L-Type; D009498:Neurotoxins; D013111:Spider Venoms