title: RegB/RegA, a global redox-responding two-component system.
abstract: The RegB-RegA regulon from Rhodobacter capsulatus and Rhodobacter sphaeroides encodes proteins involved in numerous energy-generating and energy-utilizing processes such as photosynthesis, carbon fixation, nitrogen fixation, hydrogen utilization, aerobic and anaerobic respiration, denitrification, electron transport and aerotaxis. The redox signal that is detected by the membrane-bound sensor kinase, RegB, has been identified to be the ubiquinone pool in the membrane. Regulation of RegB autophosphorylation also involves a redox-active cysteine that is present in the cytosolic region of RegB. Both phosphorylated and unphosphorylated forms of the cognate response regulator RegA are capable of activating or repressing a variety of genes in the regulon. Highly conserved homologues of RegB and RegA have been found in a wide number of photosynthetic and nonphotosynthetic bacteria with evidence suggesting that RegB/RegA have a fundamental role in the transcription of redox-regulated genes in many bacterial species.
authors.affiliation: Department of Biology, Indiana University, Myers Hall, 915 E. Third St., Bloomington, IN 47405-7170, USA.
authors.forename: Jiang
authors.initials: J
authors.lastname: Wu
authors.forename: Carl E
authors.initials: CE
authors.lastname: Bauer
mesh_terms: D000595:Amino Acid Sequence; D001419:Bacteria / Q000235:genetics; D018407:Bacterial Physiological Phenomena; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D001483:Base Sequence; D001665:Binding Sites / Q000235:genetics; D004269:DNA, Bacterial / Q000235:genetics / Q000378:metabolism; D004579:Electron Transport; D008954:Models, Biological; D008969:Molecular Sequence Data; D009586:Nitrogen Fixation; D010084:Oxidation-Reduction; D010788:Photosynthesis; D011494:Protein Kinases / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D018085:Regulon; D016992:Rhodobacter / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D015534:Trans-Activators / Q000737:chemistry / Q000235:genetics / Q000502:physiology
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial; C072722:RegA protein, Bacteria; C091084:RegA protein, Rhodobacter; C091081:RegB protein, Rhodobacter; D015534:Trans-Activators; D011494:Protein Kinases