title: Action in the axon: generation and transport of signaling endosomes.
abstract: Neurons extend axonal processes over long distances, necessitating efficient transport mechanisms to convey target-derived neurotrophic survival signals from remote distal axons to cell bodies. Retrograde transport, powered by dynein motors, supplies cell bodies with survival signals in the form of 'signaling endosomes'. In this review, we will discuss new advances in our understanding of the motor proteins that bind to and move signaling components in a retrograde direction and discuss mechanisms that might specify distinct neuronal responses to spatially restricted neurotrophin signals. Disruption of retrograde transport leads to a variety of neurodegenerative diseases, highlighting the role of retrograde transport of signaling endosomes for axonal maintenance and the importance of efficient transport for neuronal survival and function.
authors.affiliation: Department of Pediatric Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.
authors.forename: Katharina E
authors.initials: KE
authors.lastname: Cosker
authors.forename: Stephanie L
authors.initials: SL
authors.lastname: Courchesne
authors.forename: Rosalind A
authors.initials: RA
authors.lastname: Segal
mesh_terms: D000818:Animals; D001370:Axonal Transport / Q000502:physiology*; D001369:Axons / Q000502:physiology*; D011992:Endosomes / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
references.citation: Trends Cell Biol. 2004 May;14(5):233-40
references.pmid: 15130579
references.citation: Traffic. 2007 Nov;8(11):1503-20
references.pmid: 17822405
references.citation: Science. 2003 May 2;300(5620):808-12
references.pmid: 12730604
references.citation: Neuron. 2003 Jul 3;39(1):69-84
references.pmid: 12848933
references.citation: J Neurosci. 1997 Sep 15;17(18):7007-16
references.pmid: 9278536
references.citation: Exp Neurol. 2004 Feb;185(2):232-40
references.pmid: 14736504
references.citation: Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12270-5
references.pmid: 17640889
references.citation: J Cell Biol. 1995 Jul;130(1):149-56
references.pmid: 7540615
references.citation: Trends Cell Biol. 2007 Nov;17(11):519-28
references.pmid: 18029183
references.citation: Neuron. 2001 Dec 6;32(5):767-70
references.pmid: 11738023
references.citation: J Neurosci. 2005 May 25;25(21):5236-47
references.pmid: 15917464
references.citation: Nat Rev Neurosci. 2005 Mar;6(3):201-14
references.pmid: 15711600
references.citation: J Biol Chem. 1996 Jan 19;271(3):1687-94
references.pmid: 8576170
references.citation: Mol Biol Cell. 1996 Feb;7(2):331-43
references.pmid: 8688562
references.citation: Hum Mol Genet. 2007 Dec 1;16(23):2911-20
references.pmid: 17855450
references.citation: Ann Neurol. 2006 Jul;60(1):95-104
references.pmid: 16802286
references.citation: Cell. 2004 Jul 23;118(2):243-55
references.pmid: 15260993
references.citation: J Neurosci. 1999 Oct 1;19(19):8207-18
references.pmid: 10493722
references.citation: Hum Mol Genet. 2008 May 1;17(9):1245-52
references.pmid: 18203753
references.citation: Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13666-71
references.pmid: 17698956
references.citation: Nat Cell Biol. 2008 Feb;10(2):149-59
references.pmid: 18193038
references.citation: Nat Neurosci. 2001 Oct;4(10):981-8
references.pmid: 11544482
references.citation: J Neurosci. 2001 Feb 1;21(3):RC125
references.pmid: 11157096
references.citation: J Neurosci. 1999 Sep 15;19(18):7889-900
references.pmid: 10479691
references.citation: Neuron. 2003 Jul 3;39(1):57-68
references.pmid: 12848932
references.citation: Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9595-600
references.pmid: 16769894
references.citation: J Neurosci. 2008 Feb 27;28(9):1997-2005
references.pmid: 18305234
references.citation: Nat Neurosci. 2004 Jun;7(6):596-604
references.pmid: 15122257
references.citation: J Neurosci. 2007 Dec 26;27(52):14515-24
references.pmid: 18160659
references.citation: Neuron. 2008 May 22;58(4):532-45
references.pmid: 18498735
references.citation: Am J Hum Genet. 2002 Nov;71(5):1189-94
references.pmid: 12355402
references.citation: J Neurosci Res. 2007 Sep;85(12):2640-7
references.pmid: 17279546
references.citation: Science. 1997 Aug 22;277(5329):1097-100
references.pmid: 9262478
references.citation: J Clin Invest. 2004 Jan;113(2):231-42
references.pmid: 14722615
references.citation: Annu Rev Neurosci. 2000;23:39-71
references.pmid: 10845058
references.citation: J Neurobiol. 2004 Feb 5;58(2):230-43
references.pmid: 14704955
references.citation: Nat Rev Neurosci. 2005 Aug;6(8):615-25
references.pmid: 16062170
references.citation: Neuron. 2001 Dec 6;32(5):801-14
references.pmid: 11738027
references.citation: Annu Rev Neurosci. 2003;26:299-330
references.pmid: 12598680
references.citation: Biochem Soc Trans. 1995 Feb;23(1):50-4
references.pmid: 7758764
references.citation: Nat Genet. 2003 Apr;33(4):455-6
references.pmid: 12627231
references.citation: J Neurosci. 1996 Dec 15;16(24):7950-64
references.pmid: 8987823
references.citation: Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12913-8
references.pmid: 17646655
references.citation: Hum Mol Genet. 2006 Jan 15;15(2):233-50
references.pmid: 16321985
references.citation: J Cell Biol. 2008 Jun 16;181(6):1027-39
references.pmid: 18559670
references.citation: Hum Mol Genet. 2008 Jul 1;17(13):1946-55
references.pmid: 18364389
references.citation: Curr Opin Neurobiol. 2002 Jun;12(3):268-74
references.pmid: 12049932
references.citation: Curr Opin Neurobiol. 2005 Feb;15(1):40-8
references.pmid: 15721743
references.citation: Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9909-14
references.pmid: 9275225