Lack of increase in time to blood culture positivity in a patient with persistent methicillin-resistant Staphylococcus aureus bacteremia predicts failure of antimicrobial therapy.
Time to positivity is an available parameter in automated blood culture systems. We report a patient with persistent methicillin-resistant Staphylococcus aureus bacteremia who received various regimens for treatment of methicillin-resistant S. aureus, and demonstrate that monitoring of the time to positive blood culture might be helpful in the early recognition of treatment failure.
Liao
Chun-Hsing
CH
Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan.
Huang
Yu-Tsung
YT
Chu
Fang-Yeh
FY
Lin
Tsui-Hsien
TH
Hsueh
Po-Ren
PR
D000081:Acetamides / Q000627:therapeutic use; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016470:Bacteremia / Q000188:drug therapy / Q000382:microbiology*; D001769:Blood / Q000382:microbiology*; D002408:Catheters, Indwelling / Q000382:microbiology; D005260:Female; D006801:Humans; D000069349:Linezolid; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification*; D023303:Oxazolidinones / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology*; D013997:Time Factors; D017211:Treatment Failure; D014640:Vancomycin / Q000627:therapeutic use
D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D014640:Vancomycin; D000069349:Linezolid