title: Treatment planning for a synchrotron-based radiotherapy modality.
abstract: Contrast enhanced radiotherapy (CERT) achieves biologically localised dose enhancement through the preferential uptake of high-Z media by the tumour cells. A treatment planning software originally developed for boron neutron capture therapy (BNCT) has been developed to evaluate treatment plans for CERT. A realistic test case of a brain tumour based on actual CT scans was used to calculate dose distributions with and without the presence of an iodinated contrast medium. An enhancement of dose was observed at all depths with the introduction of iodine and the corresponding dose enhancement factors were calculated for various concentrations.
authors.affiliation: Department of Medical Physics, University Hospital Birmingham NHS Trust, Birmingham B15 2TH, UK. s.manolopoulos@bham.ac.uk
authors.forename: S
authors.initials: S
authors.lastname: Manolopoulos
authors.forename: C
authors.initials: C
authors.lastname: Wojnecki
authors.forename: S
authors.initials: S
authors.lastname: Green
authors.forename: R P
authors.initials: RP
authors.lastname: Hugtenburg
authors.forename: B
authors.initials: B
authors.lastname: Jones
mesh_terms: D016754:Boron Neutron Capture Therapy / Q000379:methods*; D001932:Brain Neoplasms / Q000532:radiotherapy*; D003287:Contrast Media; D006801:Humans; D007455:Iodine; D011879:Radiotherapy Dosage; D012984:Software; D017356:Synchrotrons; D014054:Tomography
chemical_list: D003287:Contrast Media; D007455:Iodine