title: Brain-derived neurotrophic factor gene variation influences cerebrospinal fluid 3-methoxy-4-hydroxyphenylglycol concentrations in healthy volunteers.
abstract: Brain-derived neurotrophic factor (BDNF) has been shown to influence monoamine transmitter synthesis, metabolism and release. We investigated possible relationships between four BDNF gene polymorphisms and cerebrospinal fluid (CSF) concentrations of 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) in healthy volunteers (n = 132). All BDNF polymorphisms (270 C/T, -633 T/A, Val66Met, and 11757 G/C) were associated with MHPG (P < 0.02), but not with 5-HIAA and HVA concentrations. At a second clinical investigation 8-20 years after CSF sampling 30% of the subjects had experienced various psychiatric disorders. Development of a psychiatric disorder was predicted by low 5-HIAA concentrations (P = 0.01). The results suggest that BDNF gene variation participates in regulation of norepinephrine turnover rates in the central nervous system of human subjects.
authors.affiliation: Department of Clinical Neuroscience, Karolinska Institute and Hospital, Stockholm, Sweden. erik.jonsson@ki.se
authors.forename: Erik G
authors.initials: EG
authors.lastname: Jönsson
authors.forename: Peter
authors.initials: P
authors.lastname: Saetre
authors.forename: Bodil
authors.initials: B
authors.lastname: Edman-Ahlbom
authors.forename: Anna
authors.initials: A
authors.lastname: Sillén
authors.forename: Agneta
authors.initials: A
authors.lastname: Gunnar
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Andreou
authors.forename: Ingrid
authors.initials: I
authors.lastname: Agartz
authors.forename: Göran
authors.initials: G
authors.lastname: Sedvall
authors.forename: Håkan
authors.initials: H
authors.lastname: Hall
authors.forename: Lars
authors.initials: L
authors.lastname: Terenius
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry / Q000235:genetics; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005820:Genetic Testing; D005838:Genotype; D006719:Homovanillic Acid / Q000032:analysis / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000032:analysis / Q000134:cerebrospinal fluid; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000032:analysis / Q000134:cerebrospinal fluid*; D019965:Neurocognitive Disorders / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D009638:Norepinephrine / Q000378:metabolism*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011237:Predictive Value of Tests; D012701:Serotonin / Q000378:metabolism; D055815:Young Adult
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D012701:Serotonin; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D009638:Norepinephrine; D006719:Homovanillic Acid
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