Spiral ganglion neurones: an overview of morphology, firing behaviour, ionic channels and function.
The spiral ganglion cells provide the afferent innervation of the hair cells of the organ of Corti. Ninety-five percent of these cells (termed type I spiral ganglion neurones) are in synaptic contact with the inner hair cells, whereas about 5% of them are type II cells, which are responsible for the sensory innervation of the outer hair cells. To understand the function of the spiral ganglion neurones, it is important to explore their membrane properties, understand their activity patterns and describe the variety of ionic channels determining their behaviour. In this review, a brief description is given of the various experimental methods that allow the investigation of the spiral ganglion cells, followed by the discussion of their action potential firing patterns and ionic conductances. The presence, distribution and significance of the K(+) currents of the spiral ganglion cells are specifically addressed, along with the introduction of the putative subunit compositions of the relevant voltage-gated K(+) channels.
Rusznák
Zoltán
Z
Department of Physiology, Medical and Health Science Centre, University of Debrecen, Debrecen, P O Box 22, H-4012, Hungary. rz@phys.dote.hu
Szucs
Géza
G
D000200:Action Potentials / Q000502:physiology; D000375:Aging; D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000494:pharmacology; D015220:Calcium Channels / Q000378:metabolism; D002478:Cells, Cultured; D004546:Elapid Venoms / Q000494:pharmacology; D006652:Histological Techniques; D006801:Humans; D009414:Nerve Growth Factors / Q000494:pharmacology; D009474:Neurons / Q000502:physiology; D009925:Organ of Corti / Q000166:cytology; D011188:Potassium / Q000378:metabolism; D015221:Potassium Channels / Q000187:drug effects / Q000502:physiology*; D015222:Sodium Channels / Q000378:metabolism; D013136:Spiral Ganglion / Q000033:anatomy & histology / Q000502:physiology*
D019208:Brain-Derived Neurotrophic Factor; D015220:Calcium Channels; D004546:Elapid Venoms; D009414:Nerve Growth Factors; D015221:Potassium Channels; D015222:Sodium Channels; C518911:neurotropin 3, mouse; C020273:dendrotoxin; D011188:Potassium
J Comp Neurol. 2002 Jun 10;447(4):331-50
11992520
Ann Otol Rhinol Laryngol. 1990 May;99(5 Pt 1):340-8
2337313
J Physiol. 1993 Jan;460:407-25
8487202
Acta Otolaryngol. 1972 Feb-Mar;73(2):235-48
5015157
J Comp Neurol. 2000 Sep 25;425(3):436-46
10972943
Exp Brain Res. 1979 Jan 15;34(2):389-93
217706
Cell Mol Life Sci. 2003 Oct;60(10):2189-99
14618265
Biochem Biophys Res Commun. 1994 Jun 30;201(3):1263-9
8024570
Eur J Neurosci. 2002 Nov;16(10):1887-95
12453052
Nature. 1989 Aug 31;340(6236):715-8
2475782
Ann Otol Rhinol Laryngol Suppl. 1979 Nov-Dec;88(6 Pt 3 Suppl 62):1-17
118697
Hear Res. 1985 Jan;17(1):1-12
3997676
Hear Res. 2005 Mar;201(1-2):132-44
15721568
Hear Res. 1989 Nov;42(2-3):167-73
2481667
Cell Calcium. 1993 Mar;14(3):245-54
8500138
Eur J Neurosci. 1997 Nov;9(11):2348-58
9464929
Brain Res. 1989 May 15;487(1):9-15
2752290
J Neurochem. 1992 Jul;59(1):93-8
1351933
Exp Brain Res. 1987;65(2):261-70
3549347
J Physiol. 1999 Aug 1;518 ( Pt 3):667-80
10420005
Hear Res. 1978 Oct;1(1):31-4
230173
J Biol Chem. 2003 Oct 17;278(42):40890-8
12923191
Am J Physiol Renal Physiol. 2001 Feb;280(2):F214-22
11208596
Hear Res. 1991 Sep;55(1):81-91
1752797
J Comp Neurol. 1946 Apr;84:141-219
20982804
Hear Res. 1985;20(1):79-84
2416731
J Neurophysiol. 1988 Sep;60(3):853-68
3171663
Acta Physiol Hung. 2004;91(2):83-98
15484709
J Neurosci. 1996 Jul 15;16(14):4457-67
8699256
Hear Res. 2006 Dec;222(1-2):89-99
17079103
Nat Neurosci. 2002 Feb;5(2):147-54
11802170
Neurochem Res. 1998 Aug;23(8):1133-8
9704604
Hear Res. 1984 Aug;15(2):113-21
6490538
J Comp Neurol. 1984 Feb 20;223(2):163-76
6200517
Neuron. 1995 Jun;14(6):1153-64
7605630
J Physiol. 1984 Feb;347:685-96
6707972
J Pharmacol Exp Ther. 1998 Jun;285(3):1051-60
9618407
J Neurophysiol. 1998 May;79(5):2503-12
9582223
J Comp Neurol. 1975 Sep 15;163(2):129-58
1100684
Acta Otolaryngol. 1983 Mar-Apr;95(3-4):263-76
6837281
Acta Otolaryngol Suppl. 1987;438:1-18
3479885
Neuroscience. 1997 Apr;77(3):673-82
9070744
J Neurophysiol. 1997 Jun;77(6):3145-56
9212264
Nat New Biol. 1971 Jun 16;231(24):222-3
4326045
J Neurophysiol. 1997 Dec;78(6):3019-27
9405521
J Neurophysiol. 1999 Dec;82(6):3307-15
10601462
Brain Res Dev Brain Res. 2000 Feb 7;119(2):297-305
10675781
Neuroreport. 1999 Aug 20;10(12):2579-86
10574373
ORL J Otorhinolaryngol Relat Spec. 1995 Mar-Apr;57(2):68-77
7537360
J Neurophysiol. 2003 Jul;90(1):444-55
12660354
Neuroreport. 2004 Mar 1;15(3):437-41
15094499
J Electron Microsc Tech. 1990 Jun;15(2):144-54
2355266
Hear Res. 1999 Dec;138(1-2):73-80
10575116
Neuroreport. 2006 Feb 6;17(2):135-9
16407759
Acta Otolaryngol. 1987 Jul-Aug;104(1-2):29-39
3661162
J Histochem Cytochem. 2003 Jan;51(1):1-4
12502748
J Physiol. 2003 Apr 1;548(Pt 1):1-20
12611922
J Comp Neurol. 1975 May 15;161(2):159-81
47866
Neuroscience. 2002;109(1):169-82
11784708
J Neurosci. 2002 Feb 15;22(4):1385-96
11850465
Hear Res. 1993 Sep;69(1-2):215-20
8226342
J Neurosci. 2004 Jan 21;24(3):733-42
14736859
Hear Res. 1997 Aug;110(1-2):179-90
9282900
Hear Res. 2003 Jan;175(1-2):165-70
12527134
J Neurosci. 2004 Nov 10;24(45):10167-75
15537887
J Physiol. 1972 Oct;226(1):263-87
5083170
Hear Res. 1999 Oct;136(1-2):151-8
10511634
Neuroscience. 2006;137(1):275-86
16289350
Trends Neurosci. 2004 Apr;27(4):210-7
15046880
Cell Tissue Res. 2003 Aug;313(2):177-86
12845523
Neuroreport. 2001 Feb 12;12(2):275-9
11209934
Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6324-7
1631126
J Neurophysiol. 1997 Mar;77(3):1294-305
9084597
J Neurosci. 2001 Sep 1;21(17):6553-60
11517244
Acta Otolaryngol. 1996 Jul;116(4):552-60
8831841
J Comp Neurol. 1998 Dec 7;402(1):129-39
9831050
J Neurosci. 2005 Aug 17;25(33):7558-66
16107643
J Neurosci. 2005 Jul 20;25(29):6857-68
16033895
Hear Res. 1994 Nov;80(2):233-40
7896581
J Neurosci Methods. 2000 Dec 15;104(1):77-86
11163413
J Neurosci. 1993 Aug;13(8):3599-611
8393487
Neuroreport. 2006 Apr 3;17(5):475-9
16543810
Hear Res. 1985 May;18(2):111-20
4044415
Toxicon. 2001 Jan;39(1):15-26
10936620
Brain Res. 1999 Nov 6;846(2):196-203
10556636
Acta Otolaryngol. 1980 Nov-Dec;90(5-6):391-7
7211332
J Neurophysiol. 1992 Oct;68(4):1384-400
1331356
Hear Res. 1983 Feb;9(2):173-84
6833161
Acta Otolaryngol. 1967;:Suppl 226:1-78
4872926
Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7693-8
9636212
Acta Otolaryngol. 1979 Mar-Apr;87(3-4):381-7
443019
Hear Res. 1986;21(2):161-5
3700254
J Acoust Soc Am. 1982 Nov;72(5):1441-9
7175031
J Comp Neurol. 1998 Oct 26;400(3):299-309
9779936
Proc Natl Acad Sci U S A. 1979 Mar;76(3):1506-9
312502
J Physiol. 1990 Feb;421:263-91
2348394
Am J Physiol. 1999 Oct;277(4):C638-44
10516093
J Physiol. 2003 Oct 15;552(Pt 2):525-33
14561834
Exp Brain Res. 1992;91(1):1-11
1363789
Brain Res. 1985 Jul 8;338(1):1-11
3896390
J Neurosci Res. 2000 Oct 1;62(1):40-55
11002286
Nature. 2000 May 11;405(6783):149-55
10821263
Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):883-8
10639174
Neuroscience. 1988 Jan;24(1):29-38
3285238
J Physiol. 1990 Jan;420:185-206
1691290
J Neurosci. 1990 Nov;10(11):3664-84
1700083
Acta Otolaryngol Suppl. 1987;436:76-84
3478961
J Comp Neurol. 1987 Jun 22;260(4):591-604
3611412
Int J Dev Neurosci. 1993 Aug;11(4):507-12
8237466
J Comp Neurol. 1980 Jul 15;192(2):265-91
7400399
Neuroscience. 1992 Dec;51(3):631-9
1283207
Brain Res. 1976 Jun 18;109(3):487-96
1276931
J Neurophysiol. 2002 Jun;87(6):2734-40
12037175
Hear Res. 1997 Jun;108(1-2):157-79
9213129
Hear Res. 1998 Jul;121(1-2):112-24
9682814
Brain Res. 2008 May 19;1210:148-62
18410910
Laryngoscope. 1990 Feb;100(2 Pt 2 Suppl 50):19-24
2299966
J Comp Neurol. 1987 Jan 22;255(4):560-70
3819031
Neuroreport. 1992 Dec;3(12):1145-8
1337286
Hear Res. 1994 May;75(1-2):121-30
8071139
Hear Res. 1993 Sep;69(1-2):182-93
7693641
Neuroscience. 1992 Dec;51(3):621-30
1336823
Hear Res. 1999 Sep;135(1-2):124-34
10491961
Science. 1985 Nov 15;230(4727):745-52
2414845
J Comp Neurol. 1990 Nov 15;301(3):443-60
2262601
J Physiol. 1990 Dec;431:291-318
1712843
Acta Otolaryngol. 2007 Jan;127(1):8-12
17364322
J Neurosci. 1995 Dec;15(12):8011-22
8613738
Int Tinnitus J. 2007;13(1):21-8
17691659
Brain Res. 1998 Sep 14;805(1-2):181-90
9733963
Hear Res. 2004 Jul;193(1-2):1-8
15219314
Hear Res. 1991 Jan;51(1):55-72
2013546
Hear Res. 2003 Mar;177(1-2):71-80
12618319
J Neurosci. 1995 Mar;15(3 Pt 2):2338-53
7891171
J Comp Neurol. 1992 May 8;319(2):312-8
1381729
Am J Physiol. 1996 Dec;271(6 Pt 1):C1817-27
8997181
Pflugers Arch. 1994 Oct;428(3-4):382-90
7816560
Curr Opin Neurobiol. 1991 Aug;1(2):215-20
1821184
J Neurosci. 2000 Jan 1;20(1):114-22
10627587
Hear Res. 1995 Nov;91(1-2):196-201
8647721
J Histochem Cytochem. 1976 Feb;24(2):468-70
1254943
Acta Otolaryngol. 1997 Jul;117(4):545-52
9288210
Neuroreport. 1997 Feb 10;8(3):591-6
9106729
J Acoust Soc Am. 1978 Feb;63(2):442-55
670542
Dev Biol. 1998 Sep 1;201(1):90-100
9733576
Neuroreport. 2000 Apr 7;11(5):957-61
10790863
Acta Otolaryngol. 1981 May-Jun;91(5-6):451-6
7023177
J Comp Neurol. 2001 Jan 8;429(2):289-98
11116221
Hear Res. 1990 Jan;43(2-3):251-61
2312416
Acta Otolaryngol. 1969 Feb-Mar;67(2):239-54
5374642
Mol Pharmacol. 1994 Jun;45(6):1227-34
7517498
Hear Res. 1989 Apr;38(3):229-42
2708165
Arch Klin Exp Ohren Nasen Kehlkopfheilkd. 1971;200(4):275-91
5159190
Acta Otolaryngol. 1975 Jan-Feb;79(1-2):11-23
1146528
Hear Res. 1988 Nov;36(2-3):213-20
2905359
J Neurosci. 1991 Sep;11(9):2865-80
1880553
Glia. 1997 Jun;20(2):127-34
9179597
J Neurophysiol. 1998 Dec;80(6):2824-35
9862887
Acta Otolaryngol. 2005 Sep;125(9):929-34
16193584
Am J Otolaryngol. 1985 Nov-Dec;6(6):453-67
3909832
Hear Res. 1985;20(3):199-205
3878839
Brain Res Brain Res Protoc. 2003 Feb;10(3):139-47
12565684
Acta Otolaryngol. 1980 Jan-Feb;89(1-2):53-62
7405577
J Physiol. 2002 Aug 1;542(Pt 3):763-78
12154177