Mechanisms of EHD/RME-1 protein function in endocytic transport.
The evolutionarily conserved Eps15 homology domain (EHD)/receptor-mediated endocytosis (RME)-1 family of C-terminal EH domain proteins has recently come under intense scrutiny because of its importance in intracellular membrane transport, especially with regard to the recycling of receptors from endosomes to the plasma membrane. Recent studies have shed new light on the mode by which these adenosine triphosphatases function on endosomal membranes in mammals and Caenorhabditis elegans. This review highlights our current understanding of the physiological roles of these proteins in vivo, discussing conserved features as well as emerging functional differences between individual mammalian paralogs. In addition, these findings are discussed in light of the identification of novel EHD/RME-1 protein and lipid interactions and new structural data for proteins in this family, indicating intriguing similarities to the Dynamin superfamily of large guanosine triphosphatases.
Grant
Barth D
BD
Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA. grant@biology.rutgers.edu
Caplan
Steve
S
D000818:Animals; D001692:Biological Transport; D004705:Endocytosis; D006801:Humans; D050356:Lipid Metabolism; D009711:Nucleotides / Q000378:metabolism; D011485:Protein Binding; D033921:Vesicular Transport Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
D009711:Nucleotides; D033921:Vesicular Transport Proteins
Biochemistry. 2004 Jun 15;43(23):7552-62
15182197
Mol Biol Cell. 2004 Aug;15(8):3698-708
15155807
J Biol Chem. 2004 Sep 17;279(38):40062-75
15247266
Traffic. 2002 Aug;3(8):575-89
12121420
J Cell Sci. 2003 May 15;116(Pt 10):1893-903
12668726
J Biol Chem. 2003 Oct 3;278(40):39104-13
12860994
Nature. 1991 May 30;351(6325):411-4
1674590
Nature. 1992 Feb 20;355(6362):733-5
1311055
Cell. 1992 Sep 4;70(5):729-40
1516131
Mol Cell Biol. 1993 Sep;13(9):5814-28
7689153
Nature. 1995 Mar 9;374(6518):190-2
7877694
Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9530-4
7568168
J Biol Chem. 1996 Sep 13;271(37):22310-4
8798389
J Cell Biol. 1996 Nov;135(4):913-24
8922376
Bioessays. 1996 Nov;18(11):885-93
8939066
Annu Rev Biochem. 1997;66:639-78
9242920
Genes Dev. 1997 Sep 1;11(17):2239-49
9303539
Science. 1998 Aug 28;281(5381):1357-60
9721102
EMBO J. 1998 Nov 16;17(22):6541-50
9822599
Mol Biol Cell. 1999 Feb;10(2):501-13
9950691
Nature. 1999 Apr 8;398(6727):481-6
10206643
Nat Rev Mol Cell Biol. 2004 Nov;5(11):886-96
15520808
J Biol Chem. 2005 Apr 29;280(17):17213-20
15710626
Mol Biol Cell. 2005 Aug;16(8):3642-58
15930129
J Cell Sci. 2005 Sep 15;118(Pt 18):4093-101
16155252
Dev Cell. 2005 Dec;9(6):791-804
16326391
Mol Biol Cell. 2006 Jan;17(1):163-77
16251358
Traffic. 2006 Jan;7(1):52-60
16445686
Mol Biol Cell. 2006 Mar;17(3):1286-97
16394106
Nature. 2006 May 25;441(7092):528-31
16648839
Mol Biol Cell. 2006 Jul;17(7):3156-75
16641372
J Biol Chem. 2006 Nov 10;281(45):34640-50
16966331
Exp Cell Res. 2007 Jan 15;313(2):219-31
17097635
Traffic. 2007 Jan;8(1):47-60
17132146
BMC Cell Biol. 2007;8:3
17233914
J Cell Sci. 2007 Mar 1;120(Pt 5):802-14
17284518
Biochem Biophys Res Commun. 2007 Jun 8;357(3):792-9
17451652
J Biol Chem. 2007 Jun 1;282(22):16612-22
17412695
Mol Biol Cell. 2007 Aug;18(8):2828-37
17507647
Nat Cell Biol. 2007 Sep;9(9):1066-73
17704769
J Biomol NMR. 2007 Dec;39(4):323-9
17899392
Traffic. 2007 Dec;8(12):1873-86
17868075
Curr Biol. 2007 Nov 20;17(22):1913-24
17997305
EMBO J. 2008 Feb 6;27(3):558-69
18200045
Mol Biol Cell. 2008 May;19(5):2059-68
18287531
Traffic. 2008 Jun;9(6):995-1018
18331452
Mol Membr Biol. 2004 Jul-Aug;21(4):269-77
15371016
Science. 2004 Sep 24;305(5692):1972-5
15448273
Cell Biochem Biophys. 2004;41(2):295-318
15475615
Nat Struct Biol. 2000 Nov;7(11):1018-22
11062555
Nat Cell Biol. 2001 Jun;3(6):567-72
11389441
Nat Cell Biol. 2001 Jun;3(6):573-9
11389442
J Biol Chem. 2001 Aug 31;276(35):33054-60
11423532
J Biol Chem. 2001 Nov 16;276(46):43103-10
11533061
FEBS Lett. 2002 Feb 20;513(1):24-9
11911876
J Cell Biol. 2002 May 13;157(4):679-91
12011113
EMBO J. 2002 Jun 3;21(11):2557-67
12032069
Biochem Biophys Res Commun. 2002 May 3;293(2):698-704
12054525
Nature. 2007 Oct 18;449(7164):923-7
17914359
Trends Biochem Sci. 1990 Nov;15(11):430-4
2126155
Exp Cell Res. 1999 Nov 25;253(1):186-209
10579923
Am J Physiol Cell Physiol. 2003 Nov;285(5):C1009-18
12839834
Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12414-9
14519844
Sci STKE. 2003 Dec 16;2003(213):re17
14679291
J Biol Chem. 2004 Mar 12;279(11):10593-605
14676205
Traffic. 2004 Mar;5(3):194-210
15086794
Mol Biol Cell. 2004 May;15(5):2410-22
15020713