title: Interregional cerebral metabolic associativity during a continuous performance task (Part I): healthy adults.
abstract: One emerging hypothesis regarding psychiatric illnesses is that they arise from the dysregulation of normal circuits or neuroanatomical patterns. In order to study mood disorders within this framework, we explored normal metabolic associativity patterns in healthy volunteers as a prelude to examining the same relationships in affectively ill patients (Part II). We applied correlational analyses to regional brain activity as measured with FDG-PET during an auditory continuous performance task (CPT) in 66 healthy volunteers. This simple attention task controlled for brain activity that otherwise might vary amongst affective and cognitive states. There were highly significant positive correlations between homologous regions in the two hemispheres in thalamic, extrapyramidal, orbital frontal, medial temporal and cerebellar areas. Dorsal frontal, lateral temporal, cingulate, and especially insula, and inferior parietal areas showed less significant homologous associativity, suggesting more specific lateralized function. The medulla and bilateral thalami exhibited the most diverse interregional associations. A general pattern emerged of cortical regions covarying inversely with subcortical structures, particularly the frontal cortex with cerebellum, amygdala and thalamus. These analytical data may help to confirm known functional and neuroanatomical relationships, elucidate others as yet unreported, and serve as a basis for comparison to patients with psychiatric illness.
authors.affiliation: Uniformed Services University of the Health Sciences, PHS, HHS, Bethesda, MD, USA.
authors.forename: Mark W
authors.initials: MW
authors.lastname: Willis
authors.forename: Brenda E
authors.initials: BE
authors.lastname: Benson
authors.forename: Terence A
authors.initials: TA
authors.lastname: Ketter
authors.forename: Tim A
authors.initials: TA
authors.lastname: Kimbrell
authors.forename: Mark S
authors.initials: MS
authors.lastname: George
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Speer
authors.forename: Peter
authors.initials: P
authors.lastname: Herscovitch
authors.forename: Robert M
authors.initials: RM
authors.lastname: Post
mesh_terms: D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism*; D001931:Brain Mapping; D002452:Cell Count; D005947:Glucose / Q000378:metabolism; D006304:Health Status; D006801:Humans; D009415:Nerve Net / Q000502:physiology*; D049268:Positron-Emission Tomography
chemical_list: D005947:Glucose
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