The effect of blastomere biopsy on preimplantation mouse embryo development and global gene expression.
The blastomere biopsy procedure does not affect preimplantation embryo development or global patterns of gene expression in a mouse model of Preimplantation Genetic Testing (PGT). However, zona breaching, which is inherent to the blastomere biopsy procedure, causes significant premature and sometimes abnormal hatching.
Duncan
Francesca E
FE
Center for Research on Reproduction and Women's Health, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Stein
Paula
P
Williams
Carmen J
CJ
Schultz
Richard M
RM
D000818:Animals; D001706:Biopsy; D001757:Blastomeres / Q000473:pathology*; D004624:Embryo Transfer / Q000379:methods*; D047108:Embryonic Development / Q000502:physiology*; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D051379:Mice; D023421:Models, Animal; D019836:Preimplantation Diagnosis / Q000379:methods; D020554:Sperm Injections, Intracytoplasmic; D013997:Time Factors
Fertil Steril. 2004 Aug;82(2):302-3
15302274
Dev Biol. 1994 Nov;166(1):259-67
7958450
Hum Reprod. 2003 Sep;18(9):1937-43
12923153
Bioessays. 1993 Aug;15(8):531-8
8135766
Fertil Steril. 2007 Dec;88(6):1497-504
17945219
Reproduction. 2004 Sep;128(3):301-11
15333781
Hum Reprod. 1990 Aug;5(6):708-14
2254404
Dev Biol. 2004 Aug 15;272(2):483-96
15282163
Nat Rev Genet. 2002 Dec;3(12):941-53
12459724
Fertil Steril. 2003 Dec;80(6):1502-3
14667890
Nature. 1988 Mar 31;332(6163):459-61
3352746
Prenat Diagn. 2001 Sep;21(9):767-80
11559914
Fertil Steril. 2007 Mar;87(3):496-503
17141767
J Reprod Fertil. 1989 Jul;86(2):679-88
2760894
Dev Biol. 2005 Oct 15;286(2):493-506
16168984
Fertil Steril. 2008 Nov;90(5):2017.e5-9
18402943
Reproduction. 2007 Jul;134(1):63-72
17641089
Aust N Z J Obstet Gynaecol. 2005 Oct;45(5):360-4
16171467