Synthesis and antiviral activity of novel derivatives of 2'-beta-C-methylcytidine.
A series of novel derivatives of 2'-C-beta-methylcytidine, involving nucleosides modified in the "upper part" of the pyrimidine base (N(4)- and/or 5-position), has been synthesized and evaluated for their inhibitory effect on in vitro replication of the hepatitis C virus and the yellow fever virus (both Flaviviridae).
Fogt
Joanna
J
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
Januszczyk
Piotr
P
Framski
Grzegorz
G
Onishi
Tomoyuki
T
Izawa
Kunisuke
K
De Clercq
Erik
E
Neyts
Johan
J
Boryski
Jerzy
J
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003562:Cytidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D016174:Hepacivirus / Q000187:drug effects; D015005:Yellow fever virus / Q000187:drug effects
D000998:Antiviral Agents; D003562:Cytidine