title: Small RNA-directed heterochromatin formation in the context of development: what flies might learn from fission yeast.
abstract: A link between the RNAi system and heterochromatin formation has been established in several model organisms including Schizosaccharomyces pombe and Arabidopsis thaliana. However, the data to support a role for small RNAs and the associated machinery in transcriptional gene silencing in animal systems is more tenuous. Using the S. pombe system as a model, we analyze the role of small RNA pathway components and associated small RNAs in regulating transposable elements and potentially directing heterochromatin formation at these elements in Drosophila melanogaster.
authors.affiliation: Department of Biology, Washington University, St Louis, MO 63130, USA. khuising@wustl.edu
authors.forename: Kathryn L
authors.initials: KL
authors.lastname: Huisinga
authors.forename: Sarah C R
authors.initials: SC
authors.lastname: Elgin
mesh_terms: D000818:Animals; D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism; D004251:DNA Transposable Elements / Q000502:physiology*; D004331:Drosophila melanogaster; D020868:Gene Silencing / Q000502:physiology*; D006570:Heterochromatin / Q000235:genetics / Q000378:metabolism*; D012331:RNA, Fungal / Q000235:genetics / Q000378:metabolism*; D018749:RNA, Plant / Q000235:genetics / Q000378:metabolism; D034741:RNA, Small Interfering / Q000235:genetics / Q000378:metabolism*; D012568:Schizosaccharomyces / Q000235:genetics / Q000378:metabolism*
chemical_list: D004251:DNA Transposable Elements; D006570:Heterochromatin; D012331:RNA, Fungal; D018749:RNA, Plant; D034741:RNA, Small Interfering
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