title: Elevated serum angiopoietin 2 levels are associated with increased mortality in sepsis.
abstract: The vascular growth factor angiopoietin 2 (Ang-2) is known to promote inflammation and endothelial dysfunction, but its prognostic capacity and relationship to outcomes in human sepsis are unknown. This is a prospective observational cohort study of 66 patients newly admitted to a tertiary care medical intensive care unit (ICU), which included ICU patients with no sepsis (n = 20) as well as those with sepsis (n = 10), severe sepsis (n = 12), and septic shock (n = 24). Clinical data were collected until hospital discharge, and Ang-2 and IL-6 levels were determined on specimens obtained after ICU admission. Serum Ang-2 correlated with IL-6 and severity-of-illness scores. In the septic cohort, circulating Ang-2 levels were significantly higher (P = 0.01) in those who died (24.9 ng/mL; interquartile range, 21.5-38.0 ng/mL) compared with those who survived (13.5 ng/mL; interquartile range, 8.1-21.6 ng/mL). Elevated circulating serum Ang-2 levels are associated with increased hospital mortality in patients with sepsis.
authors.affiliation: Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8057, USA. jonathan.siner@yale.edu
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Siner
authors.forename: Vineet
authors.initials: V
authors.lastname: Bhandari
authors.forename: Kathryn M
authors.initials: KM
authors.lastname: Engle
authors.forename: Jack A
authors.initials: JA
authors.lastname: Elias
authors.forename: Mark D
authors.initials: MD
authors.lastname: Siegel
mesh_terms: D018806:APACHE; D000328:Adult; D000368:Aged; D042702:Angiopoietin-2 / Q000097:blood*; D003422:Critical Care; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D018805:Sepsis / Q000097:blood* / Q000401:mortality*
chemical_list: D042702:Angiopoietin-2