Clinical evaluation of a dentifrice containing calcium sodium phosphosilicate (novamin) for the treatment of dentin hypersensitivity.
OBJECTIVE
To evaluate the efficacy of a dentifrice containing calcium sodium phosphosilicate (NovaMin) study versus a placebo and a commercially-available SrCl2 containing dentifrice for the treatment of dentin hypersensitivity.


METHODS
This was a 6-week, randomized, parallel-arm, double-blind clinical study. 71 subjects ranging in age from 21 to 56 years old completed the study. Evaporative and thermal stimuli were used to measure pain using a VAS scale. Measurements were obtained at baseline, 2 weeks and 6 weeks.


RESULTS
The placebo and the NovaMin groups showed a statistically significant decrease in sensitivity by both measures after 6 weeks (P < 0.05). The SrCl2 group showed a statistically significant decrease from baseline at the 2-week time point, but not at the 6-week time point for the evaporative stimulus. The percent reduction in sensitivity at 6 weeks for the NovaMin test group was 35% for air and 39% for cold water stimulus, versus 11% for air and 22% for cold water for the SrCl2 paste. The reductions for the placebo paste were 21% for the air stimulus and 18% for water. A cross tabulation measure of the reduction in sensitivity at each time point for all three treatments showed that the NovaMin product was more effective than either of the other products. For the air stimulus in the NovaMin group, 58% of subjects improved at each time point compared with 26% for the SrCl2 group and 20% for the placebo group. These results demonstrate that the NovaMin dentifrice was more effective at reducing sensitivity compared with a commercial dentifrice and placebo control.
Du Min
Quan
Q
School of Stomatology, Wuhan University, Wuhan, China.
Bian
Zhuan
Z
Jiang
Han
H
Greenspan
David C
DC
Burwell
Anora K
AK
Zhong
Jipin
J
Tai
Bao Jun
BJ
D000328:Adult; D000388:Air; D001031:Apatites / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry; D002130:Calcium Phosphates / Q000627:therapeutic use; D002254:Carbonates / Q000737:chemistry; D003080:Cold Temperature; D003802:Dentifrices / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D005898:Glass / Q000737:chemistry; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010919:Placebos; D017640:Silicates / Q000627:therapeutic use; D013324:Strontium / Q000627:therapeutic use; D013997:Time Factors; D014099:Toothbrushing / Q000295:instrumentation
D001031:Apatites; D001672:Biocompatible Materials; D002130:Calcium Phosphates; D002254:Carbonates; D003802:Dentifrices; C510984:NovaMin; D010919:Placebos; D017640:Silicates; C413465:hydroxycarbonate apatite; C076375:rhenanite; C025700:strontium chloride; D013324:Strontium