title: [The expression of inhibitor-1 of DNA binding/differentiation-1 and thrombospondin-1 in mucoepidermoid carcinoma of different malignant degree].
abstract: OBJECTIVE
  To study the expression of inhibitor-1 of DNA binding/differentiation-1 (Id-1) and thrombospondin-1 (TSP-1) genes in mucoepidermoid carcinoma of different malignant degree and analyze the relationship between them.
  
  
  METHODS
  Using immunohistochemistry (IHC) staining technique, TSP-1 and Id-1 proteins in the mucoepidermoid carcinoma of different malignant degree, including well-differentiated, moderately differentiated and poorly differentiated mucoepidermoid carcinoma, and normal salivary gland tissues were detected.
  
  
  RESULTS
  The positive rate of Id-1 and TSP-1 in normal salivary glands were apparently lower than that in malignant mucoepidermoid carcinoma(P = 0.000, P = 0.013). The positive rate of Id-1 in moderately and poorly differentiated mucoepidermoid carcinoma was higher than that of the well-differentiated (P = 0.001, P = 0.002). However, the positive expression of Id-1 showed no relationship between the moderately and poorly differentiated mucoepidermoid carcinoma(P > 0.05). The positive rate of TSP-1 in poorly differentiated mucoepidermoid carcinoma was less than that of the well-differentiated(P = 0.014). The positive expression of TSP-1 showed no relationship between the moderately and poorly differentiated mucoepidermoid carcinoma(P > 0.05), and the positive expression of it also showed no relationship between the moderately and well differentiated mucoepidermoid carcinoma (P > 0.05). The expression of Id-1 and TSP-1 showed negative correlation(r = -0.394, P = 0.002).
  
  
  CONCLUSIONS
  The expression of TSP-1 may inhibit the development of the mucoepidermoid carcinoma, contrarily, the expression of Id-1 may prompt the development of the mucoepidermoid carcinoma. The expression of Id-1 and TSP-1 has negative correlation.
authors.affiliation: State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China.
authors.forename: Sen
authors.initials: S
authors.lastname: Yang
authors.forename: An
authors.initials: A
authors.lastname: Li
authors.forename: Li-juan
authors.initials: LJ
authors.lastname: Guo
authors.forename: Tao
authors.initials: T
authors.lastname: Yu
authors.forename: Ren-guo
authors.initials: RG
authors.lastname: Gong
authors.forename: Rui-sheng
authors.initials: RS
authors.lastname: Xu
authors.forename: Qing-hong
authors.initials: QH
authors.lastname: Gao
authors.forename: Ming
authors.initials: M
authors.lastname: Xuan
authors.forename: Chang-mei
authors.initials: CM
authors.lastname: Wang
authors.forename: Xiao-yi
authors.initials: XY
authors.lastname: Wang
mesh_terms: D000368:Aged; D018277:Carcinoma, Mucoepidermoid; D002454:Cell Differentiation; D004247:DNA; D006801:Humans; D007150:Immunohistochemistry; D012468:Salivary Gland Neoplasms; D019700:Thrombospondin 1
chemical_list: D019700:Thrombospondin 1; D004247:DNA