Advances in susceptibility genetics of intervertebral degenerative disc disease.
The traditional view that the etiology of lumbar disc herniation is primarily due to age, gender, occupation, smoking and exposure to vehicular vibration dominated much of the last century. Recent research indicates that heredity may be largely responsible for the degeneration as well as herniation of intervertebral discs. Since 1998, genetic influences have been confirmed by the identification of several genes forms associated with disc degeneration. These researches are paving the way for a better understanding of the biologic mechanisms. Now, many researchers unanimously agree that lumbar disc herniation appears to be similar to other complex diseases, whose etiology has both environmental and hereditary influence, each with a part of contribution and relative risk. Then addressing the etiological of lumbar disc herniation, it is important to integrate heredity with the environment factors. For the purpose of this review, we have limited our discussion to several susceptibility genes associated with disc degeneration.
Zhang
Yin'gang
Y
Department of Orthopaedics of the First Affiliated Hospital, Medical College of Xi'an Jiaotong University, Xi'an 710061, China. zyingang@mail.xjtu.edu.cn
Sun
Zhengming
Z
Liu
Jiangtao
J
Guo
Xiong
X
D024042:Collagen Type I / Q000235:genetics; D024141:Collagen Type IV / Q000235:genetics; D024081:Collagen Type IX / Q000235:genetics; D024121:Collagen Type X / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D007403:Intervertebral Disc / Q000378:metabolism* / Q000473:pathology; D007405:Intervertebral Disc Displacement / Q000235:genetics* / Q000473:pathology; D019278:Matrix Metalloproteinase 3 / Q000235:genetics; D018167:Receptors, Calcitriol / Q000235:genetics
C120768:COL9A3 protein, human; D024042:Collagen Type I; D024141:Collagen Type IV; D024081:Collagen Type IX; D024121:Collagen Type X; D018167:Receptors, Calcitriol; D019278:Matrix Metalloproteinase 3
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