title: Acute trimethyltin exposure induces oxidative stress response and neuronal apoptosis in Sebastiscus marmoratus.
abstract: Trimethyltin (TMT) is a well-documented neurotoxicant that affects the function of central nervous system (CNS). In this study, we studied the neurotoxicity of TMT on the brain of marine fish Sebastiscus marmoratus. Our results showed that TMT acute exposure induced brain cell apoptosis in the telencephalon, optic tectum and cerebellum. In addition, we observed increased production of reactive oxygen species (ROS), nitric oxide (NO) and one asparate-specific cysteinyl protease named caspase-3 which are often associated with the processes of cell apoptosis, in the brain of S. marmoratus after acute treatment of TMT. Our results indicated that TMT induces neurotoxicity and oxidative stress in marine fish S. marmoratus. Our results suggested that TMT exposure in the environment may affect fish behaviors including schooling, sensory and motorial learnings, based on the observation of cell apoptosis in the cerebral regions.
authors.affiliation: Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen City 361005, PR China.
authors.forename: Xinli
authors.initials: X
authors.lastname: Wang
authors.forename: Jiali
authors.initials: J
authors.lastname: Cai
authors.forename: Jiliang
authors.initials: J
authors.lastname: Zhang
authors.forename: Chonggang
authors.initials: C
authors.lastname: Wang
authors.forename: Ang
authors.initials: A
authors.lastname: Yu
authors.forename: Yixin
authors.initials: Y
authors.lastname: Chen
authors.forename: Zhenghong
authors.initials: Z
authors.lastname: Zuo
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D001711:Biotransformation; D001921:Brain / Q000166:cytology / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D053148:Caspase 3 / Q000378:metabolism; D019363:Cytochrome P-450 CYP1A1 / Q000037:antagonists & inhibitors / Q000378:metabolism; D020287:In Situ Nick-End Labeling; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D009474:Neurons / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D009498:Neurotoxins / Q000493:pharmacokinetics / Q000633:toxicity*; D009569:Nitric Oxide / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D010473:Perciformes / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D014001:Tin / Q000378:metabolism; D014298:Trimethyltin Compounds / Q000493:pharmacokinetics / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000493:pharmacokinetics / Q000633:toxicity*
chemical_list: D009498:Neurotoxins; D017382:Reactive Oxygen Species; D014298:Trimethyltin Compounds; D014874:Water Pollutants, Chemical; C046488:trimethyltin; D009569:Nitric Oxide; D014001:Tin; D052247:Nitric Oxide Synthase Type II; D019363:Cytochrome P-450 CYP1A1; D053148:Caspase 3