Isolation and genotype analysis of rubella virus from a case of Guillain-Barré syndrome.
Rubella virus (RV) infection has sporadically been linked to Guillain-Barré syndrome (GBS), but the association with RV has been based only on clinical and/or serological backgrounds. In the present case it was possible to isolate RV (genotype 1a) from cerebrospinal fluid and peripheral blood mononuclear cells of an 18-year-old woman diagnosed with GBS after clinical manifestations of rubella. This report contributes to confirm RV as one of the triggering pathogens of this peripheral nervous system disease.
Figueiredo
C A
CA
Instituto Adolfo Lutz, Seção de Vírus Produtores de Exantemas, Av. Dr. Arnaldo, 355, São Paulo, SP, 01246-902, Brazil. figueiredocris@uol.com.br
Klautau
G B
GB
Afonso
A M S
AM
Castrignano
S B
SB
Oliveira
M I
MI
Curti
S P
SP
Squarcina
G G
GG
Narimatsu
K
K
Rasslan
Z
Z
Lima
C A C
CA
Golin
V
V
Tadeo
E F
EF
Spagunolo
F J
FJ
Cataldo
B
B
Durigon
E L
EL
D000293:Adolescent; D001769:Blood / Q000821:virology; D002555:Cerebrospinal Fluid / Q000821:virology; D005260:Female; D020275:Guillain-Barre Syndrome / Q000821:virology*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000821:virology; D012412:Rubella virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification