Role of B cells in systemic lupus erythematosus and rheumatoid arthritis.
B cell tolerance to many self-proteins is actively maintained by either purging self-reactive B receptors through clonal deletion and receptor editing, or by functional silencing known as anergy. However, these processes are clearly incomplete as B cell driven autoimmune diseases still occur. The significance of B cells in two such diseases, rheumatoid arthritis and systemic lupus erythematosus, is highlighted by the ameliorative effects of B cell depletion. It remains to be determined, however, whether the key role of the B cell in autoimmune disease is autoantibody production or another antibody-independent function.
Mandik-Nayak
Laura
L
Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, United States. Mandik-Nayakl@mlhs.org
Ridge
Natalie
N
Fields
Michele
M
Park
Audrey Y
AY
Erikson
Jan
J
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000628:therapy; D001323:Autoantibodies / Q000097:blood; D001324:Autoantigens / Q000276:immunology*; D015551:Autoimmunity / Q000276:immunology*; D016175:B-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D017637:Clonal Deletion / Q000276:immunology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology* / Q000628:therapy; D008212:Lymphocyte Depletion; D051379:Mice; D008822:Mice, Transgenic; D011947:Receptors, Antigen, B-Cell / Q000276:immunology* / Q000378:metabolism; D017634:Self Tolerance / Q000276:immunology
D001323:Autoantibodies; D001324:Autoantigens; D011947:Receptors, Antigen, B-Cell
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