title: Transepidermal water loss (TEWL) reflects skin barrier function of dog.
abstract: The correlation between skin barrier function and transepidermal water loss (TEWL) was evaluated in dogs. Stratum corneum (SC) of 10 healthy dogs was removed by tape stripping (TS), which decreased the corneal layer to allow for permeation of fluorescent dye into skin. TEWL of damaged skin was measured with the closed-chamber-type TEWL analyzer, CC-01. The frequency of TS was directly related to the decrease of SC and the increased permeation of fluorescent dye, and TEWL increased with increasing impairment of skin barrier function. The results suggest that increased TEWL reflects impaired canine skin barrier function.
authors.affiliation: Department of Veterinary Internal Medicine, Faculty of Agriculture, Tokyo University of Agriculture & Technology, Fuchu, Tokyo, Japan.
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Shimada
authors.forename: Toru
authors.initials: T
authors.lastname: Yoshihara
authors.forename: Masahiko
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Konno
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Momoi
authors.forename: Koji
authors.initials: K
authors.lastname: Nishifuji
authors.forename: Toshiroh
authors.initials: T
authors.lastname: Iwasaki
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000503:physiopathology; D004285:Dogs / Q000502:physiology*; D004817:Epidermis / Q000502:physiology*; D005260:Female; D005456:Fluorescent Dyes; D008297:Male; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000503:physiopathology / Q000662:veterinary; D012879:Skin Physiological Phenomena; D014870:Water Loss, Insensible / Q000502:physiology*
chemical_list: D005456:Fluorescent Dyes