title: Schizophrenia: a computational reinforcement learning perspective.
authors.affiliation: Department of Psychology, Program in Neuroscience, University of Arizona, Tucson, AZ 85721, USA. mfrank@u.arizona.edu
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Frank
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use; D002394:Catechol O-Methyltransferase / Q000502:physiology; D003072:Cognition Disorders / Q000188:drug therapy / Q000503:physiopathology; D003342:Corpus Striatum / Q000187:drug effects / Q000503:physiopathology; D004298:Dopamine / Q000502:physiology; D006801:Humans; D008570:Memory, Short-Term / Q000187:drug effects / Q000502:physiology; D009042:Motivation; D009415:Nerve Net / Q000187:drug effects / Q000503:physiopathology; D016571:Neural Networks, Computer; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology; D017397:Prefrontal Cortex / Q000187:drug effects / Q000503:physiopathology*; D011337:Probability Learning; D017447:Receptors, Dopamine D1 / Q000187:drug effects / Q000502:physiology; D017448:Receptors, Dopamine D2 / Q000187:drug effects / Q000502:physiology; D012201:Reward; D012559:Schizophrenia / Q000188:drug therapy / Q000503:physiopathology*
chemical_list: D014150:Antipsychotic Agents; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D002394:Catechol O-Methyltransferase; D004298:Dopamine
references.citation: J Comput Neurosci. 2006 Apr;20(2):153-66
references.pmid: 16699839
references.citation: Philos Trans R Soc Lond B Biol Sci. 2007 Sep 29;362(1485):1641-54
references.pmid: 17428775
references.citation: Mol Psychiatry. 2008 Mar;13(3):239, 267-76
references.pmid: 17684497
references.citation: J Neurosci. 2004 Sep 22;24(38):8214-22
references.pmid: 15385604
references.citation: Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16311-6
references.pmid: 17913879
references.citation: Brain Res Brain Res Rev. 1998 Dec;28(3):309-69
references.pmid: 9858756
references.citation: Brain Res Cogn Brain Res. 2005 Dec;25(3):851-61
references.pmid: 16289773
references.citation: Schizophr Bull. 2008 Sep;34(5):835-47
references.pmid: 18591195
references.citation: Behav Pharmacol. 2003 Feb;14(1):49-53
references.pmid: 12576881
references.citation: BMC Psychiatry. 2008 May 08;8:34
references.pmid: 18466609
references.citation: Biol Cybern. 2005 Jun;92(6):427-37
references.pmid: 15915357
references.citation: Nat Neurosci. 2008 Jan;11(1):103-7
references.pmid: 18066057
references.citation: Arch Gen Psychiatry. 1987 Jul;44(7):660-9
references.pmid: 3606332
references.citation: J Clin Invest. 2007 Mar;117(3):672-82
references.pmid: 17290303
references.citation: Ann N Y Acad Sci. 2003 Nov;1003:398-401
references.pmid: 14684471
references.citation: Science. 2007 Nov 23;318(5854):1309-12
references.pmid: 17962524
references.citation: Science. 2007 Dec 7;318(5856):1642-5
references.pmid: 18063800
references.citation: Nature. 2006 Jun 15;441(7095):876-9
references.pmid: 16778890
references.citation: Behav Pharmacol. 2003 Nov;14(7):563-7
references.pmid: 14557724
references.citation: Nature. 2008 Jun 12;453(7197):879-84
references.pmid: 18496528
references.citation: Biol Cybern. 2001 Jun;84(6):401-10
references.pmid: 11417052
references.citation: J Neurosci. 1996 Mar 1;16(5):1936-47
references.pmid: 8774460
references.citation: Am J Psychiatry. 2003 Jan;160(1):13-23
references.pmid: 12505794
references.citation: Neuropsychologia. 2006;44(10):1663-73
references.pmid: 16730032
references.citation: J Cogn Neurosci. 2005 Jan;17(1):51-72
references.pmid: 15701239
references.citation: Am J Psychiatry. 2003 Dec;160(12):2209-15
references.pmid: 14638592
references.citation: Arch Gen Psychiatry. 2003 Dec;60(12):1187-92
references.pmid: 14662550
references.citation: Cogn Affect Behav Neurosci. 2001 Jun;1(2):137-60
references.pmid: 12467110
references.citation: J Neurosci. 2000 Nov 15;20(22):8443-51
references.pmid: 11069952
references.citation: Brain. 2008 May;131(Pt 5):1323-31
references.pmid: 18344561
references.citation: Biol Psychiatry. 1999 Aug 1;46(3):312-28
references.pmid: 10435197
references.citation: Schizophr Res. 2003 Apr 1;60(2-3):285-98
references.pmid: 12591590
references.citation: J Neurosci. 2007 May 16;27(20):5506-14
references.pmid: 17507572
references.citation: Neural Netw. 2004 May;17(4):471-510
references.pmid: 15109680
references.citation: Mol Psychiatry. 2008 Aug;13(8):821-7
references.pmid: 18317466
references.citation: Mol Psychiatry. 2009 Jan;14(1):60-70
references.pmid: 17893706
references.citation: Schizophr Bull. 2008 Sep;34(5):816-8
references.pmid: 18640995
references.citation: Psychopharmacology (Berl). 2007 Apr;191(3):507-20
references.pmid: 17031711
references.citation: Behav Neurosci. 2006 Jun;120(3):497-517
references.pmid: 16768602
references.citation: Neuropsychologia. 2008 Nov;46(13):3144-56
references.pmid: 18687347
references.citation: Psychol Rev. 1992 Jan;99(1):45-77
references.pmid: 1546118
references.citation: Proc Natl Acad Sci U S A. 2007 May 8;104(19):8125-30
references.pmid: 17483451
references.citation: Nat Neurosci. 2005 Dec;8(12):1704-11
references.pmid: 16286932
references.citation: Neuropsychologia. 2008 Apr;46(5):1326-37
references.pmid: 18242647
references.citation: Mol Psychiatry. 2004 Dec;9(12):1060-1
references.pmid: 15278099
references.citation: Synapse. 1987;1(2):133-52
references.pmid: 2905529
references.citation: Int Rev Neurobiol. 2007;78:41-68
references.pmid: 17349857
references.citation: Biol Psychiatry. 2007 Oct 1;62(7):756-64
references.pmid: 17300757
references.citation: Neuropsychopharmacology. 2007 Jul;32(7):1583-99
references.pmid: 17164816
references.citation: Science. 2004 Dec 10;306(5703):1940-3
references.pmid: 15528409
references.citation: Network. 2006 Mar;17(1):61-84
references.pmid: 16613795
references.citation: Psychol Rev. 2006 Apr;113(2):300-326
references.pmid: 16637763
references.citation: Science. 2008 Aug 8;321(5890):848-51
references.pmid: 18687967
references.citation: Neural Comput. 2006 Feb;18(2):283-328
references.pmid: 16378516
references.citation: Mol Psychiatry. 2008 Mar;13(3):233-8
references.pmid: 18285755
references.citation: Neuron. 2002 Oct 10;36(2):241-63
references.pmid: 12383780
references.citation: J Neurosci. 2007 Oct 17;27(42):11424-30
references.pmid: 17942737
references.citation: Arch Gen Psychiatry. 2001 Mar;58(3):280-8
references.pmid: 11231835
references.citation: Brain. 2007 Sep;130(Pt 9):2387-400
references.pmid: 17690132