title: Estimating child mortality due to diarrhoea in developing countries.
abstract: OBJECTIVE
  The major objective of this study is to provide estimates of diarrhoea mortality at country, regional and global level by employing the Child Health Epidemiology Reference Group (CHERG) standard.
  
  
  METHODS
  A systematic and comprehensive literature review was undertaken of all studies published since 1980 reporting under-5 diarrhoea mortality. Information was collected on characteristics of each study and its population. A regression model was used to relate these characteristics to proportional mortality from diarrhoea and to predict its distribution in national populations.
  
  
  RESULTS
  Global deaths from diarrhoea of children aged less than 5 years were estimated at 1.87 million (95% confidence interval, CI: 1.56-2.19), approximately 19% of total child deaths. WHO African and South-East Asia Regions combined contain 78% (1.46 million) of all diarrhoea deaths occurring among children in the developing world; 73% of these deaths are concentrated in just 15 developing countries.
  
  
  CONCLUSIONS
  Planning and evaluation of interventions to control diarrhoea deaths and to reduce under-5 mortality is obstructed by the lack of a system that regularly generates cause-of-death information. The methods used here provide country-level estimates that constitute alternative information for planning in settings without adequate data.
authors.affiliation: Child and Adolescent Health, World Health Organization, Geneva, Switzerland. pintoc@who.int
authors.forename: Cynthia
authors.initials: C
authors.lastname: Boschi-Pinto
authors.forename: Lana
authors.initials: L
authors.lastname: Velebit
authors.forename: Kenji
authors.initials: K
authors.lastname: Shibuya
mesh_terms: D046688:Child Mortality / Q000639:trends*; D002675:Child, Preschool; D003906:Developing Countries / Q000706:statistics & numerical data; D003967:Diarrhea / Q000401:mortality*; D006801:Humans; D007223:Infant; D007226:Infant Mortality / Q000639:trends*; D007231:Infant, Newborn; D012042:Registries
references.citation: Emerg Infect Dis. 2003 May;9(5):565-72
references.pmid: 12737740
references.citation: Lancet. 2003 Jun 28;361(9376):2226-34
references.pmid: 12842379
references.citation: J Trop Pediatr. 1985 Oct;31(5):268-72
references.pmid: 3877814
references.citation: Bull World Health Organ. 1992;70(6):705-14
references.pmid: 1486666
references.citation: Rev Epidemiol Sante Publique. 1989;37(2):161-6
references.pmid: 2772361
references.citation: Ann Trop Paediatr. 1993;13(4):345-52
references.pmid: 7506881
references.citation: Bull World Health Organ. 1996;74(5):547-52
references.pmid: 9002335
references.citation: J Diarrhoeal Dis Res. 1991 Dec;9(4):323-7
references.pmid: 1800564
references.citation: Int J Epidemiol. 2006 Jun;35(3):691-704
references.pmid: 16507643
references.citation: World Health Stat Q. 1992;45(2-3):180-91
references.pmid: 1462653
references.citation: Lancet. 2005 Mar 26-Apr 1;365(9465):1147-52
references.pmid: 15794969
references.citation: Lancet. 2005 Mar 5-11;365(9462):891-900
references.pmid: 15752534
references.citation: J Trop Pediatr. 1987 Aug;33(4):190-3
references.pmid: 3669135
references.citation: Lancet. 1991 Oct 19;338(8773):993-7
references.pmid: 1681351
references.citation: Lancet. 1990 Jul 28;336(8709):201-6
references.pmid: 1973770
references.citation: Bull World Health Organ. 2005 Aug;83(8):618-25
references.pmid: 16184281
references.citation: Lancet. 2005 Jun 11-17;365(9476):2031-40
references.pmid: 15950717
references.citation: Trans R Soc Trop Med Hyg. 1992 Mar-Apr;86(2):216-20
references.pmid: 1440794
references.citation: Salud Publica Mex. 1994 Mar-Apr;36(2):243-6
references.pmid: 8073339
references.citation: Trop Med Int Health. 1999 Jun;4(6):433-41
references.pmid: 10444319
references.citation: Indian J Pediatr. 1996 May-Jun;63(3):363-8
references.pmid: 10830012
references.citation: Indian J Pediatr. 1992 Sep-Oct;59(5):567-71
references.pmid: 1459678
references.citation: J Diarrhoeal Dis Res. 1993 Mar;11(1):25-9
references.pmid: 8315250
references.citation: Rev Saude Publica. 1995 Apr;29(2):132-9
references.pmid: 8525323
references.citation: Int J Epidemiol. 1993 Feb;22(1):72-80
references.pmid: 8449650
references.citation: J Trop Pediatr. 1991 Feb;37(1):31-6
references.pmid: 2023300
references.citation: Trop Med Int Health. 1997 Jan;2(1):28-37
references.pmid: 9018300
references.citation: Med Trop (Mars). 1984 Jan-Mar;44(1):27-31
references.pmid: 6738335
references.citation: J Epidemiol Community Health. 2000 Apr;54(4):247-53
references.pmid: 10827906
references.citation: Int J Epidemiol. 1992 Oct;21(5):911-5
references.pmid: 1468852
references.citation: Bull Pan Am Health Organ. 1985;19(1):29-39
references.pmid: 4027452
references.citation: Int J Epidemiol. 1997 Oct;26(5):1090-6
references.pmid: 9363532
references.citation: Acta Paediatr. 2001 Jun;90(6):682-90
references.pmid: 11440104
references.citation: Stud Fam Plann. 1982 Nov;13(11):315-27
references.pmid: 6965183
references.citation: Lancet Infect Dis. 2002 Jan;2(1):25-32
references.pmid: 11892493
references.citation: Rev Panam Salud Publica. 2000 May;7(5):303-12
references.pmid: 10893970
references.citation: Int J Epidemiol. 2003 Dec;32(6):1041-51
references.pmid: 14681271
references.citation: Int J Epidemiol. 1987 Jun;16(2):239-45
references.pmid: 3610450
references.citation: Bull Soc Pathol Exot. 1993;86(5):373-9
references.pmid: 8124110
references.citation: Bull World Health Organ. 1990;68(5):577-85
references.pmid: 2289294
references.citation: J Trop Med Hyg. 1990 Apr;93(2):87-97
references.pmid: 2325198
references.citation: Trop Med Parasitol. 1992 Dec;43(4):229-33
references.pmid: 1293726
references.citation: N Engl J Med. 1990 Oct 4;323(14):929-35
references.pmid: 2205798
references.citation: Bull World Health Organ. 2005 Mar;83(3):171-7
references.pmid: 15798840
references.citation: Ann Trop Paediatr. 1987 Jun;7(2):91-9
references.pmid: 2441658
references.citation: J Trop Pediatr. 1990 Dec;36(6):287-93
references.pmid: 2280435
references.citation: Trans R Soc Trop Med Hyg. 1986;80(6):851-8
references.pmid: 3603635
references.citation: J R Soc Health. 1993 Oct;113(5):247-9
references.pmid: 8230076
references.citation: Bull World Health Organ. 1982;60(4):605-13
references.pmid: 6982783
references.citation: Lancet. 1993 Jul 3;342(8862):7-12
references.pmid: 8100345
references.citation: J Trop Pediatr. 1991 Oct;37(5):254-61
references.pmid: 1784061
references.citation: Soc Sci Med. 1996 Jun;42(11):1599-604
references.pmid: 8771643
references.citation: Int J Epidemiol. 1980 Mar;9(1):25-33
references.pmid: 7419328
references.citation: Am J Trop Med Hyg. 1987 May;36(3):598-602
references.pmid: 3578657
references.citation: Arch Dis Child. 1987 May;62(5):487-90
references.pmid: 3606182
references.citation: Soc Sci Med. 1997 Oct;45(7):1031-40
references.pmid: 9257395
references.citation: Bull World Health Organ. 2002;80(5):391-8
references.pmid: 12077615
references.citation: Int J Epidemiol. 2001 Jun;30(3):509-14
references.pmid: 11416073
references.citation: J Biosoc Sci. 1990 Jul;22(3):349-63
references.pmid: 2401677
references.citation: Int J Epidemiol. 1993;22 Suppl 1:S56-63
references.pmid: 8307676
references.citation: Stud Fam Plann. 1989 May-Jun;20(3):136-46
references.pmid: 2734810
references.citation: Bull World Health Organ. 2003;81(3):197-204
references.pmid: 12764516
references.citation: Bull World Health Organ. 2006 Mar;84(3):181-8
references.pmid: 16583076
references.citation: Bull World Health Organ. 1998;76(2):161-71
references.pmid: 9648357