title: [Dysregulation of homeostasis in severe sepsis: relevance and therapeutic options].
abstract: Severe sepsis and septic shock may have a lasting effect on all human endocrinologic, coagulatory and metabolic regulatory circuits with the consequence of severe dysregulation of homoeostasis. Adjunctive therapeutic options like intensive insulin therapy, low-dose hydrocortisone and modulation of coagulation by drotrecogin alfa (activated) are still controversial discussed, but should be used according to the national and international guidelines for a sophisticated treatment of septic heterostasis.
authors.affiliation: Chefarzt der Klinik für Anästhesiologie, Intensiv- und Schmerztherapie sowie des Funktionsbereiches Palliativmedizin am Klinikum St. Georg gGmbH in Leipzig. armin.sablotzki@sanktgeorg.de
authors.forename: Armin
authors.initials: A
authors.lastname: Sablotzki
authors.forename: Marius G
authors.initials: MG
authors.lastname: Dehne
authors.forename: Elke
authors.initials: E
authors.lastname: Czeslick
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use; D001424:Bacterial Infections / Q000150:complications* / Q000628:therapy*; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use*; D008659:Metabolic Diseases / Q000150:complications* / Q000628:therapy*; D011486:Protein C / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D007328:Insulin; D011486:Protein C; D011994:Recombinant Proteins; C421124:drotrecogin alfa activated; D006854:Hydrocortisone