Caudate nucleus volumes in frontotemporal lobar degeneration: differential atrophy in subtypes.
OBJECTIVE
Frontostriatal circuits involving the caudate nucleus have been implicated in frontotemporal lobar degeneration (FTLD). We assessed caudate nucleus volumetrics in FTLD and subtypes: frontotemporal dementia (FTD, n = 12), semantic dementia (SD, n = 13), and progressive nonfluent aphasia (PNFA, n = 9) in comparison with healthy controls (n = 27) and subjects with Alzheimer disease (AD, n = 19).


METHODS
Diagnoses were based on accepted clinical criteria. Manual volume measurement of the head and body of the caudate, excluding the tail, was conducted on T1-weighted brain MR imaging scans, using a published protocol, by a single analyst blinded to the diagnosis.


RESULTS
Paired t tests (P < .05) showed that the right caudate nucleus volume was significantly larger than the left in controls and PNFA. No hemispheric asymmetry was found in AD, FTD, and SD. Across the groups, there was a positive partial correlation between the left caudate nucleus volume and Mini-Mental State Examination (MMSE) scores (r = 0.393, n = 76, P = .001) with higher left caudate volumes associated with higher MMSE scores. Multivariate analysis of covariance was used to assess the statistical significance between the subject groups (AD, FTD, SD, PNFA, and controls) as independent variables and raw right/left caudate volumes at the within-subject level (covariates: age and intracranial volume; P < .05). Control volume was largest, followed by AD (93% of control volume), SD (92%), PNFA (79%), and FTD (75%).


CONCLUSIONS
Volume of the head and body of the caudate nucleus differs in subtypes of FTLD, due to differential frontostriatal dysfunction in subtypes being reflected in structural change in the caudate, and is correlated with cognition.
Looi
J C L
JC
Academic Unit of Psychological Medicine, Research Centre for Neurosciences of Ageing, Australian National University Medical School, The Canberra Hospital, Canberra, Australia. Jeffrey.looi@anu.edu.au
Lindberg
O
O
Zandbelt
B B
BB
Ostberg
P
P
Andersen
C
C
Botes
L
L
Svensson
L
L
Wahlund
L-O
LO
D000328:Adult; D000368:Aged; D001284:Atrophy / Q000473:pathology; D002421:Caudate Nucleus / Q000473:pathology*; D003704:Dementia / Q000473:pathology*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
J Psychiatr Res. 1975 Nov;12(3):189-98
1202204
Magn Reson Med. 2000 Dec;44(6):973-7
11108637
Psychiatry Res. 2008 Aug 30;163(3):279-88
18657402
Neurology. 1998 Dec;51(6):1546-54
9855500
Lancet Neurol. 2005 Nov;4(11):771-80
16239184
Arch Neurol. 1993 Aug;50(8):873-80
8352676
Cereb Cortex. 2006 Oct;16(10):1508-21
16373457
Brain Res Brain Res Rev. 1995 Jan;20(1):91-127
7711769
Neuropsychologia. 1997 Apr;35(4):533-45
9106281
J Psychosom Res. 2002 Aug;53(2):647-54
12169339
Acad Radiol. 2000 Aug;7(8):627-34
10952114
Annu Rev Neurosci. 1986;9:357-81
3085570
Neurosci Lett. 2007 May 29;419(2):113-8
17485168
Psychiatry Res. 2009 Feb 28;171(2):138-43
19176278
Cereb Cortex. 2006 Jul;16(7):916-28
16207933
J Comput Assist Tomogr. 1998 Jan-Feb;22(1):139-52
9448779
Neuroimage. 2007 Jul 1;36(3):497-510
17478101
Neurobiol Learn Mem. 1995 Mar;63(2):133-42
7663886
J Speech Hear Disord. 1987 Nov;52(4):367-87
3312817
J Neurol Neurosurg Psychiatry. 2007 Nov;78(11):1165-6
17940166
J Clin Exp Neuropsychol. 1999 Aug;21(4):435-43
10550804
Psychol Bull. 1979 Mar;86(2):420-8
18839484