Multiple basal cell carcinomas in xeroderma pigmentosum treated with imiquimod 5% cream.
We report successful treatment of multiple basal cell carcinomas with imiquimod 5% cream in a 16-year-old boy with xeroderma pigmentosum and review the possibility of prophylactic role of imiquimod in the disease. Imiquimod cream was applied uniformly over all the basal cell carcinoma lesions and background pigmented skin, once at bedtime on every alternate day for 12 weeks. Besides the basal cell carcinomas, the background hyperpigmentation and keratotic papules also cleared, and the skin texture improved. The lesions did not recur at the treated sites during the follow up of 1 year.
Malhotra
Amit Kumar
AK
Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
Gupta
Somesh
S
Khaitan
Binod K
BK
Verma
Kaushal K
KK
D000293:Adolescent; D000634:Aminoquinolines / Q000008:administration & dosage*; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002280:Basal Cell Carcinoma / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D000077271:Imiquimod; D008297:Male; D009824:Ointments; D012878:Skin Neoplasms / Q000150:complications / Q000188:drug therapy*; D014983:Xeroderma Pigmentosum / Q000150:complications / Q000188:drug therapy*
D000634:Aminoquinolines; D000970:Antineoplastic Agents; D009824:Ointments; D000077271:Imiquimod