title: Extract from Acanthopanax senticosus harms (Siberian ginseng) activates NTS and SON/PVN in the rat brain.
abstract: The extract of the stem bark of Siberian ginseng, Acanthopanax senticosus Harms (ASH), is believed to play a body-coping role in stress through a brain noradrenergic mechanism. The present study was carried out to investigate the effect of ASH on the neuronal activation patterns of c-Fos expression in the rat brain. With ASH administration, c-Fos accumulated in both the supraoptic nuclei (SON) and paraventricular nuclei (PVN), which regulate stress response. Only the caudal regions in the nucleus of the solitary tract (NTS), a locus innervating both the SON and PVN, were activated. Such a neuro-anatomical pattern associated with ASH suggests the possible involvement of these stress-related brain loci.
authors.affiliation: Laboratory of Exercise Biochemistry, University of Tsukuba Graduate School of Comprehensive Human Sciences, Tsukuba, Japan. hsoya@taiiku.tsukuba.ac.jp
authors.forename: Hideaki
authors.initials: H
authors.lastname: Soya
authors.forename: Custer C
authors.initials: CC
authors.lastname: Deocaris
authors.forename: Kaoru
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Nao
authors.initials: N
authors.lastname: Ohiwa
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Saito
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nishijima
authors.forename: Morimasa
authors.initials: M
authors.lastname: Kato
authors.forename: Masaru
authors.initials: M
authors.lastname: Tateoka
authors.forename: Takashi
authors.initials: T
authors.lastname: Matsui
authors.forename: Masahiro
authors.initials: M
authors.lastname: Okamoto
authors.forename: Takahiko
authors.initials: T
authors.lastname: Fujikawa
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D028001:Eleutherococcus / Q000235:genetics / Q000378:metabolism*; D008297:Male; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects* / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017552:Solitary Nucleus / Q000378:metabolism*; D013495:Supraoptic Nucleus / Q000187:drug effects* / Q000378:metabolism
chemical_list: D010936:Plant Extracts