title: Testing percutaneous arterial closure devices: an animal model.
abstract: The ovine superficial femoral artery was used for testing the efficacy of percutaneous arterial closure devices (PACDs) in their developmental stage. Two topical devices containing chitostan, one staple-mediated PACD and a porcine small intestinal submucosa plug, were tested by follow-up angiography in 37 sheep. Absence or presence of bleeding and time to bleeding cessation were the main criteria for evaluation of PAVD efficacy. The results of these tests directed modification of individual PACDs and improved their efficacy.
authors.affiliation: Dotter Interventional Institute, Oregon Health Sciences University, Portland, OR 97201, USA.
authors.forename: Rui-Fang
authors.initials: RF
authors.lastname: Ni
authors.forename: Pawanrat
authors.initials: P
authors.lastname: Kranokpiraksa
authors.forename: Dusan
authors.initials: D
authors.lastname: Pavcnik
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kakizawa
authors.forename: Barry T
authors.initials: BT
authors.lastname: Uchida
authors.forename: Frederick S
authors.initials: FS
authors.lastname: Keller
authors.forename: Josef
authors.initials: J
authors.lastname: Rösch
mesh_terms: D000792:Angiography; D000818:Animals; D048271:Chitosan / Q000494:pharmacology*; D005260:Female; D005263:Femoral Artery / Q000000981:diagnostic imaging / Q000601:surgery*; D006489:Hemostatic Techniques / Q000295:instrumentation*; D007413:Intestinal Mucosa / Q000637:transplantation*; D023421:Models, Animal; D012756:Sheep; D017792:Surgical Stapling; D013552:Swine; D014654:Vascular Patency; D014656:Vascular Surgical Procedures / Q000295:instrumentation*; D014945:Wound Healing
chemical_list: D048271:Chitosan