title: Bridging the gap between schizophrenia and psychotic mood disorders: Relating neurocognitive deficits to psychopathology.
abstract: BACKGROUND
  The neurobiological relationship between schizophrenia and psychotic mood disorders is not well understood. Neurocognitive deficits have been described in both types of disorders and have been proposed to reflect underlying neurobiological dysfunction. Examining the relationship between neurocognitive function and psychopathology could help illuminate the neurobiological relationship between schizophrenia and psychotic mood disorders.
  
  
  METHODS
  Participants included 72 individuals with DSM-IV schizophrenia, 25 individuals with schizoaffective disorder or bipolar disorder with psychotic features, and 72 community controls. Standardized scores and correlations between four domains of neurocognition and psychopathology were examined.
  
  
  RESULTS
  Individuals with schizophrenia and psychotic mood disorders scored similarly on several dimensions of neurocognitive function and psychopathology. The relationships between neurocognitive function and psychopathology were similar in the two groups.
  
  
  CONCLUSIONS
  Individuals with schizophrenia and psychotic mood disorders were similar in terms of both the level of impairment in neurocognitive function and psychopathology, as well as in the relationship between the two dimensions of illness. These results suggest that schizophrenia and psychotic mood disorders such as schizoaffective disorder and bipolar disorder with psychotic features are on a neurobiological continuum.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA. matthewsmith@northwestern.edu
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Smith
authors.forename: Deanna M
authors.initials: DM
authors.lastname: Barch
authors.forename: John G
authors.initials: JG
authors.lastname: Csernansky
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011618:Psychotic Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology*; D012559:Schizophrenia / Q000175:diagnosis / Q000453:epidemiology*; D012565:Schizophrenic Psychology; D012720:Severity of Illness Index
references.citation: Schizophr Res. 2004 Dec 15;72(1):41-51
references.pmid: 15531406
references.citation: Harv Rev Psychiatry. 2006 Mar-Apr;14(2):47-63
references.pmid: 16603472
references.citation: Schizophr Res. 2002 Jan 15;53(3):209-18
references.pmid: 11738534
references.citation: Schizophr Res. 2008 Feb;99(1-3):149-54
references.pmid: 18031992
references.citation: Schizophr Bull. 2000;26(1):119-36
references.pmid: 10755673
references.citation: Schizophr Res. 1998 May 25;31(2-3):99-111
references.pmid: 9689714
references.citation: Schizophr Bull. 2008 Jan;34(1):109-17
references.pmid: 17515440
references.citation: J Psychiatr Res. 2001 Mar-Apr;35(2):119-25
references.pmid: 11377441
references.citation: J Affect Disord. 2008 May;108(1-2):71-86
references.pmid: 18029027
references.citation: Arch Gen Psychiatry. 1995 May;52(5):341-51
references.pmid: 7726714
references.citation: Bipolar Disord. 2006 Apr;8(2):117-23
references.pmid: 16542181
references.citation: J Clin Psychiatry. 1999 Dec;60(12):874-82
references.pmid: 10665641
references.citation: Am J Psychiatry. 1970 Jan;126(7):983-7
references.pmid: 5409569
references.citation: Am J Psychiatry. 1995 May;152(5):755-64
references.pmid: 7726316
references.citation: Br J Psychiatry. 1980 Dec;137:497-504
references.pmid: 7214104
references.citation: J Abnorm Psychol. 2004 Nov;113(4):556-68
references.pmid: 15535788
references.citation: Psychiatry Res. 2006 Aug 30;143(2-3):255-87
references.pmid: 16857267
references.citation: Curr Opin Psychiatry. 2007 Jul;20(4):365-79
references.pmid: 17551352
references.citation: Schizophr Res. 2004 Dec 15;72(1):29-39
references.pmid: 15531405
references.citation: Biol Psychiatry. 2007 Jul 15;62(2):179-86
references.pmid: 17161829
references.citation: Compr Psychiatry. 2004 Sep-Oct;45(5):392-400
references.pmid: 15332203
references.citation: Arch Gen Psychiatry. 2007 May;64(5):566-76
references.pmid: 17485608
references.citation: Arch Gen Psychiatry. 1987 May;44(5):441-7
references.pmid: 3579495
references.citation: Arch Gen Psychiatry. 2005 Oct;62(10):1081-8
references.pmid: 16203953
references.citation: Annu Rev Clin Psychol. 2005;1:321-53
references.pmid: 17716091
references.citation: Schizophr Res. 2000 Apr 7;42(2):83-90
references.pmid: 10742646
references.citation: Psychiatry Res. 2002 May 15;110(1):49-61
references.pmid: 12007593
references.citation: Compr Psychiatry. 1995 Sep-Oct;36(5):353-61
references.pmid: 7497709
references.citation: Schizophr Bull. 2007 Jul;33(4):912-20
references.pmid: 17567627
references.citation: Am J Psychiatry. 2003 Jan;160(1):4-12
references.pmid: 12505793
references.citation: Eur Arch Psychiatry Clin Neurosci. 1996;246(2):63-70
references.pmid: 9063910
references.citation: Schizophr Bull. 2007 Jul;33(4):863-7
references.pmid: 17548844
references.citation: Arch Gen Psychiatry. 1998 Jun;55(6):492-9
references.pmid: 9633666
references.citation: Int Rev Psychiatry. 2005 Feb;17(1):9-19
references.pmid: 16194767
references.citation: J Abnorm Psychol. 2003 Feb;112(1):132-43
references.pmid: 12653421
references.citation: Am J Psychiatry. 2002 Dec;159(12):2027-35
references.pmid: 12450952