title: A protein interaction network analysis for yeast integral membrane protein.
abstract: Although the yeast Saccharomyces cerevisiae is the best exemplified single-celled eukaryote, the vast number of protein-protein interactions of integral membrane proteins of Saccharomyces cerevisiae have not been characterized by experiments. Here, based on the kernel method of Greedy Kernel Principal Component analysis plus Linear Discriminant Analysis, we identify 300 protein-protein interactions involving 189 membrane proteins and get the outcome of a highly connected protein-protein interactions network. Furthermore, we study the global topological features of integral membrane proteins network of Saccharomyces cerevisiae. These results give the comprehensive description of protein-protein interactions of integral membrane proteins and reveal global topological and robustness of the interactome network at a system level. This work represents an important step towards a comprehensive understanding of yeast protein interactions.
authors.affiliation: Intelligent Computing Lab, Hefei Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei Anhui, 230031, China.
authors.forename: Ming-Guang
authors.initials: MG
authors.lastname: Shi
authors.forename: De-Shuang
authors.initials: DS
authors.lastname: Huang
authors.forename: Xue-Ling
authors.initials: XL
authors.lastname: Li
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D016002:Discriminant Analysis; D008565:Membrane Proteins / Q000378:metabolism*; D025341:Principal Component Analysis; D025941:Protein Interaction Mapping / Q000706:statistics & numerical data; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D020798:Two-Hybrid System Techniques
chemical_list: D008565:Membrane Proteins; D029701:Saccharomyces cerevisiae Proteins