[Preoperative evaluation of liver function using 99mTc-diethyl iminodiacetic acid based on single photon emission computed tomography].
OBJECTIVE
To establish a three-dimentional liver function evaluation system using 99mTc-diethyl iminodiacetic acid (99mTc-EHIDA) scintigraphy based on single photon emission computed tomography (SPECT).


METHODS
Totally 16 patients with liver lesions were divided into cirrhosis group and non-cirrhosis group. SPECT was performed 2 days before operation and 5 days after operation. Serum liver functions were examined on the same day of scintigraphy. SPECT images of areas of interest of heart and liver were aquired. Time of the peak of EHIDA density in liver (Tpeak), five-minutes heart liver index (HLI5), blood clearance index (HH15), receptor index (LHL15), and the predictive values were calculated.


RESULTS
Tpeak was not significantly different between two groups, while HLI5, HH15, and LHL15 were significantly different (P = 0.033, P = 0.001, and P = 0.005). HLI, and LHL15 were significantly correlated with preoperative total protein and prealbumin levels (P = 0.003, P = 0.015, P = 0.022, P = 0.038) and post-operative prealbumin (P = 0.037, P = 0.042). The predictive values of HLI5 and LHL15 correlated well with postoperative HLI5 and LHL15 (r = 0.675, P = 0.016; r = 0.629, P = 0.028).


CONCLUSIONS
The three-dimentional liver function evaluation system using 99mTc-EHIDA based on liver SPECT may facilitate the further studies of risks of liver surgery.
Du
Shun-da
SD
Department of Liver Surgery, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Mao
Yi-lei
YL
Li
Fang
F
Ouyang
Meng
M
Tong
Jun-xiang
JX
Sang
Xin-ting
XT
Yang
Zhi-ying
ZY
Lu
Xin
X
Chi
Tian-yi
TY
Zhao
Hai-tao
HT
Xu
Yi-yao
YY
Xu
Hai-feng
HF
Zhong
Shou-xian
SX
Huang
Jie-fu
JF
D000328:Adult; D000368:Aged; D000818:Animals; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D057234:Preoperative Period; D019275:Radiopharmaceuticals / Q000008:administration & dosage*; D019784:Technetium Tc 99m Diethyl-iminodiacetic Acid / Q000008:administration & dosage*; D015899:Tomography, Emission-Computed, Single-Photon
D019275:Radiopharmaceuticals; D019784:Technetium Tc 99m Diethyl-iminodiacetic Acid