[Dysregulation of homeostasis in severe sepsis: relevance and therapeutic options].
Severe sepsis and septic shock may have a lasting effect on all human endocrinologic, coagulatory and metabolic regulatory circuits with the consequence of severe dysregulation of homoeostasis. Adjunctive therapeutic options like intensive insulin therapy, low-dose hydrocortisone and modulation of coagulation by drotrecogin alfa (activated) are still controversial discussed, but should be used according to the national and international guidelines for a sophisticated treatment of septic heterostasis.
Sablotzki
Armin
A
Chefarzt der Klinik für Anästhesiologie, Intensiv- und Schmerztherapie sowie des Funktionsbereiches Palliativmedizin am Klinikum St. Georg gGmbH in Leipzig. armin.sablotzki@sanktgeorg.de
Dehne
Marius G
MG
Czeslick
Elke
E
D000890:Anti-Infective Agents / Q000627:therapeutic use; D001424:Bacterial Infections / Q000150:complications* / Q000628:therapy*; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use*; D008659:Metabolic Diseases / Q000150:complications* / Q000628:therapy*; D011486:Protein C / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000627:therapeutic use
D000890:Anti-Infective Agents; D007328:Insulin; D011486:Protein C; D011994:Recombinant Proteins; C421124:drotrecogin alfa activated; D006854:Hydrocortisone