title: Focal nodular hyperplasia of the liver in patients previously treated for pediatric neoplastic diseases.
abstract: The discovery of a liver nodule during postcancer follow-up suggests malignancy recurrence. However, patients previously treated for pediatric cancers are at greater risk of developing benign hepatic tumors, raising the problems of getting an accurate noninvasive diagnosis. Here we report 3 cases of focal nodular hyperplasia of the liver in patients previously treated for pediatric neoplastic diseases. Radiologic findings and needle-biopsies remained insufficient in 2 cases to rule out metastasis or a potentially threatening tumor. Only surgical resection led to positive diagnosis and prevented complications. However, a review of the literature shows that if the nodule presents with typical features of focal nodular hyperplasia a close imaging follow-up is all that is recommended.
authors.affiliation: Département de Pédiatrie, Centre Léon Bérard, Lyon, France. marabell@lyon.fnclcc.fr
authors.forename: Aurélien
authors.initials: A
authors.lastname: Marabelle
authors.forename: Denis
authors.initials: D
authors.lastname: Campagne
authors.forename: Pierre
authors.initials: P
authors.lastname: Déchelotte
authors.forename: Jacques
authors.initials: J
authors.lastname: Chipponi
authors.forename: François
authors.initials: F
authors.lastname: Deméocq
authors.forename: Justyna
authors.initials: J
authors.lastname: Kanold
mesh_terms: D000236:Adenoma / Q000175:diagnosis; D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000150:complications*; D000328:Adult; D001707:Biopsy, Needle; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D002897:Chromosomes, Human, Pair 7; D002921:Cicatrix / Q000209:etiology; D003937:Diagnosis, Differential; D005260:Female; D020518:Focal Nodular Hyperplasia / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology / Q000601:surgery; D006086:Graft vs Host Disease / Q000473:pathology; D006801:Humans; D007680:Kidney Neoplasms / Q000150:complications*; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D008113:Liver Neoplasms / Q000175:diagnosis / Q000556:secondary; D008297:Male; D009006:Monosomy; D009447:Neuroblastoma / Q000150:complications* / Q000556:secondary; D010198:Pancytopenia / Q000150:complications / Q000235:genetics / Q000601:surgery; D011859:Radiography; D012074:Remission Induction; D014463:Ultrasonography; D009396:Wilms Tumor / Q000150:complications* / Q000556:secondary