Gender difference regarding schizandrin pharmacokinetics in rats.
The difference in the pharmacokinetics of schizandrin (SZ) in male and female rats was studied. SZ concentrations in the plasma were determined after the intragastric (i.g) administration of 10 mg/kg and the intravenous (i.v) administration of 5 mg/kg in male and female rats, respectively. It was found that the plasma concentrations of SZ in female rats were significantly higher than those in male rats. Drug absolute bioavailability, based on the area under curve (AUC(0-tn)), in female rats was roughly 20 times of that in male rats. The terminate half-life (T(1/2)) in male rats was shorter than that in female rats. These results demonstrate the existence of marked gender differences for SZ in rats.
Xu
Mei-Juan
MJ
Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, Peoples Republic of China.
Wang
Guang-Ji
GJ
Xie
Hai-Tang
HT
Li
Hao
H
Huang
Qing
Q
Wang
Rui
R
Jia
Yuan-Wei
YW
Lv
Tian
T
D000818:Animals; D001682:Biological Availability; D034242:Cyclooctanes / Q000493:pharmacokinetics*; D003627:Data Interpretation, Statistical; D005260:Female; D006207:Half-Life; D007275:Injections, Intravenous; D007441:Intubation, Gastrointestinal; D017705:Lignans / Q000493:pharmacokinetics*; D008297:Male; D013058:Mass Spectrometry; D011083:Polycyclic Compounds / Q000493:pharmacokinetics*; D051381:Rats; D012727:Sex Characteristics
D034242:Cyclooctanes; D017705:Lignans; D011083:Polycyclic Compounds; C011105:schizandrin
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