title: [Kappa light chain deposition disease, presenting as Sjögren's syndrome, successfully treated by high-dose melphalan and autologous blood stem transplantation].
abstract: BACKGROUND
  Light chain deposition disease is a systemic disorder characterised by tissue deposition of monoclonal immunoglobulin light chains without tinctorial properties. It has been exceptionally reported with salivary involvement mimicking Sjögren's syndrome and peripheral neuropathy.
  
  
  METHODS
  We report a case of light chain deposition disease associated with plasma cell dyscrasia presenting as sicca syndrome with salivary glands hypertrophy and polyneuropathy successfully treated by high dose melphalan and autologous blood stem transplantation.
  
  
  CONCLUSIONS
  Light chain deposition disease should be recognized as an aetiology of sicca syndrome and peripheral neuropathy. Further studies should assess the prevalence of sicca syndrome in light chain deposition disease and better characterise the neurological manifestations.
authors.affiliation: Service de médecine interne, hôpital Jean-Minjoz, CHU de Besançon, boulevard Fleming, 25030 Besançon cedex, France. cfoguem@chu-besancon.fr
authors.forename: C
authors.initials: C
authors.lastname: Foguem
authors.forename: B
authors.initials: B
authors.lastname: Kantelip
authors.forename: E
authors.initials: E
authors.lastname: Deconinck
authors.forename: C
authors.initials: C
authors.lastname: Hafsaoui
authors.forename: N
authors.initials: N
authors.lastname: Méaux-Ruault
authors.forename: H
authors.initials: H
authors.lastname: Gil
authors.forename: N
authors.initials: N
authors.lastname: Magy-Bertrand
authors.forename: J-L
authors.initials: JL
authors.lastname: Dupond
mesh_terms: D001706:Biopsy; D003937:Diagnosis, Differential; D004576:Electromyography; D005260:Female; D006801:Humans; D006984:Hypertrophy; D007145:Immunoglobulin kappa-Chains; D008558:Melphalan / Q000008:administration & dosage*; D010265:Paraproteinemias / Q000150:complications / Q000175:diagnosis; D010523:Peripheral Nervous System Diseases / Q000150:complications / Q000175:diagnosis; D012469:Salivary Glands / Q000473:pathology; D012796:Sialography; D012859:Sjogren's Syndrome / Q000175:diagnosis*; D033581:Stem Cell Transplantation; D014057:Tomography, X-Ray Computed; D014182:Transplantation, Autologous
chemical_list: D007145:Immunoglobulin kappa-Chains; D008558:Melphalan