Synthesis of novel fluorophores for labelling of oligonucleotides.
Some novel fluorophores, viz. 2-(4-Carboxymethyl-naphthalene-1-carbonyl)-benzoic acid (1), 7, 12-Dioxo-7, 12 dihydro-benzo[a] anthracene 5-yl]-acetic acid (2), [7,12-Dibenzylidine-7,12-Dihydro-benzo[a] anthracene-5-yl]-acetic acid (3), 2-[1-(4-carboxy methyl naphthalene-1-yl)-2-phenyl-vinyl]-benzoic acid (4) and (12-benzylidine-7-oxo-7, 12-dihydro-benzo[a] anthracene-5-yl)-acetic acid (5) have been designed and synthesized. These fluorophores have shown very good fluorescence signals in UV-visible region.
Singh
Ajay
A
Nucleic Acids Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad-211002, India.
Singh
Ramendra K
RK
D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D015345:Oligonucleotide Probes / Q000737:chemistry*; D011084:Polycyclic Aromatic Hydrocarbons / Q000138:chemical synthesis / Q000737:chemistry
D005456:Fluorescent Dyes; D015345:Oligonucleotide Probes; D011084:Polycyclic Aromatic Hydrocarbons