Pro- and anti-fibrotic effects of TGF-beta in scleroderma.
The University of California at Davis 200 and 206 (UCD-200/206) lines of chickens have proven to be the animal model that best reflects the situation in human SSc. We have demonstrated a misbalance of pro-fibrotic (TGF-beta1) and anti-fibrotic (TGF-beta2 and -beta3) TGF-beta isoforms as a possible cause for fibrotic alterations in this model. This opens new avenues for diagnosis and therapy for this still intractable condition.
Sgonc
R
R
Division of Experimental Pathophysiology and Immunology, Laboratory of Autoimmunity, Biocenter, Medical University of Innsbruck, Peter-Mayr-Strasse 4a, A-6020 Innsbruck, Austria.
Wick
G
G
D000818:Animals; D002645:Chickens; D005355:Fibrosis; D023421:Models, Animal; D012595:Scleroderma, Systemic / Q000378:metabolism* / Q000473:pathology; D012867:Skin / Q000378:metabolism* / Q000473:pathology; D016212:Transforming Growth Factor beta / Q000502:physiology*
D016212:Transforming Growth Factor beta
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