A rat model of chronic kidney disease-mineral bone disorder.
Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) is a newly defined syndrome encompassing patients with chronic kidney disease that have a triad of biochemical alterations in calcium, phosphorus and parathyroid hormone, vascular calcification, and bone abnormalities. Here we describe a novel Cy/+ rat model of slowly progressive kidney disease spontaneously developing the three components of CKD-MBD when fed a normal phosphorus diet. Since the renal disorder progressed 'naturally' we studied the effect of dietary manipulation during the course of the disease. Animals with early, but established, chronic kidney disease were fed a casein-based or a grain-based protein diet both of which had equivalent total phosphorus contents. The two different sources of dietary protein had profound effects on the progression of CKD-MBD, likely due to differences in intestinal bioavailability of phosphorus. Although both dietary treatments resulted in the same serum phosphorous levels, the casein-fed animals had increased urinary phosphorus excretion and elevated serum FGF23 compared to the grain-fed rats. This model should help identify early changes in the course of chronic kidney disease that may lead to CKD-MBD.
Moe
Sharon M
SM
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46260, USA. smoe@iupui.edu
Chen
Neal X
NX
Seifert
Mark F
MF
Sinders
Rachel M
RM
Duan
Dana
D
Chen
Xianming
X
Liang
Yun
Y
Radcliff
J Scott
JS
White
Kenneth E
KE
Gattone
Vincent H
VH
D000818:Animals; D002364:Caseins / Q000008:administration & dosage / Q000494:pharmacology; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000378:metabolism*; D004195:Disease Models, Animal; D018450:Disease Progression; D002523:Edible Grain; D005346:Fibroblast Growth Factors / Q000032:analysis; D007408:Intestinal Absorption; D007676:Kidney Failure, Chronic / Q000150:complications*; D008903:Minerals / Q000378:metabolism*; D010758:Phosphorus / Q000097:blood / Q000493:pharmacokinetics / Q000652:urine; D051381:Rats
D002364:Caseins; C505605:Fgf23 protein, rat; D008903:Minerals; D010758:Phosphorus; D005346:Fibroblast Growth Factors
J Am Soc Nephrol. 2005 Dec;16(12):3517-26
16207829
Kidney Int. 2005 Oct;68(4):1815-24
16164659
Kidney Int. 2006 Nov;70(9):1577-83
16955099
Kidney Int. 2007 Jan;71(1):31-8
17091124
Adv Chronic Kidney Dis. 2007 Jan;14(1):3-12
17200038
Am J Physiol Renal Physiol. 2007 Feb;292(2):F599-606
16968889
Kidney Int. 2007 Feb;71(4):298-303
17149373
Kidney Int. 2007 Nov;72(10):1255-61
17805238
J Am Soc Nephrol. 2008 Feb;19(2):213-6
18094365
Kidney Int. 2000 Jan;57(1):159-66
10620197
Semin Dial. 2000 May-Jun;13(3):152-5
10833774
Kidney Int. 2001 Jan;59(1):52-61
11135057
Am J Kidney Dis. 2001 Jan;37(1 Suppl 2):S54-7
11158862
Kidney Int. 2002 Feb;61(2):638-47
11849407
J Am Soc Nephrol. 2002 Sep;13(9):2299-308
12191974
J Clin Endocrinol Metab. 2002 Nov;87(11):4957-60
12414858
Nephrol Dial Transplant. 2002 Dec;17(12):2132-7
12454223
J Am Soc Nephrol. 2003 Jun;14(6):1559-67
12761256
Kidney Int. 2003 Aug;64(2):441-50
12846739
J Environ Qual. 2003 Jul-Aug;32(4):1481-9
12931905
Nephrol Dial Transplant. 2003 Sep;18(9):1770-6
12937223
J Nutr. 2004 Jun;134(6):1504-7
15173419
J Nutr. 2004 Aug;134(8):1874-80
15284369
Kidney Int. 1973 Aug;4(2):141-5
4355426
J Bone Miner Res. 1987 Dec;2(6):595-610
3455637
Transplant Proc. 1990 Dec;22(6):2582-3
2264162
Am J Pathol. 1991 Sep;139(3):693-6
1887867
Kidney Int. 1993 Mar;43(3):522-34
8455352
Am J Kidney Dis. 1996 Jun;27(6):865-79
8651252
Am J Kidney Dis. 1997 Feb;29(2):265-72
9016899
J Bone Miner Res. 1999 Feb;14(2):256-63
9933480
J Am Soc Nephrol. 2005 Jan;16(1):109-16
15563564
Am J Kidney Dis. 2005 May;45(5):963
15861369
Kidney Int. 2005 Sep;68(3):1258-66
16105059
Endocr Rev. 2006 May;27(3):221-41
16467171