PCA-HPR: a principle component analysis model for human promoter recognition.
We describe a promoter recognition method named PCA-HPR to locate eukaryotic promoter regions and predict transcription start sites (TSSs). We computed codon (3-mer) and pentamer (5-mer) frequencies and created codon and pentamer frequency feature matrices to extract informative and discriminative features for effective classification. Principal component analysis (PCA) is applied to the feature matrices and a subset of principal components (PCs) are selected for classification. Our system uses three neural network classifiers to distinguish promoters versus exons, promoters versus introns, and promoters versus 3' un-translated region (3'UTR). We compared PCA-HPR with three well-known existing promoter prediction systems such as DragonGSF, Eponine and FirstEF. Validation shows that PCA-HPR achieves the best performance with three test sets for all the four predictive systems.
Li
Xiaomeng
X
Department of Electronic Engineering, City University of Hong Kong, Kowloon, Hong Kong. sgusico@hotmail.com
Zeng
Jia
J
Yan
Hong
H
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