title: A new family of tunable indolylphosphine ligands by one-pot assembly and their applications in Suzuki-Miyaura coupling of aryl chlorides.
abstract: This study describes a new class of indolylphosphine ligands, which can be easily accessed by a simple one-pot assembly from commercially available indoles, acid chlorides, and chlorophosphines. A combination of these three starting materials provides a high diversification of the ligand structure. The application of this ligand array in palladium-catalyzed Suzuki-Miyaura coupling reaction of aryl chlorides with arylboronic acids is described. A catalyst loading down to 0.01 mol % of Pd can be achieved.
authors.affiliation: Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The Hong Kong Polytechnic University, Kowloon, Hong Kong.
authors.forename: Chau Ming
authors.initials: CM
authors.lastname: So
authors.forename: Chung Chiu
authors.initials: CC
authors.lastname: Yeung
authors.forename: Chak Po
authors.initials: CP
authors.lastname: Lau
authors.forename: Fuk Yee
authors.initials: FY
authors.lastname: Kwong
mesh_terms: D001897:Boronic Acids; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry; D008024:Ligands; D008722:Methods; D010720:Phosphines / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D001897:Boronic Acids; D006843:Hydrocarbons, Chlorinated; D007211:Indoles; D008024:Ligands; D010720:Phosphines