title: Synthesis and antiviral activity of novel derivatives of 2'-beta-C-methylcytidine.
abstract: A series of novel derivatives of 2'-C-beta-methylcytidine, involving nucleosides modified in the "upper part" of the pyrimidine base (N(4)- and/or 5-position), has been synthesized and evaluated for their inhibitory effect on in vitro replication of the hepatitis C virus and the yellow fever virus (both Flaviviridae).
authors.affiliation: Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Fogt
authors.forename: Piotr
authors.initials: P
authors.lastname: Januszczyk
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Framski
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Onishi
authors.forename: Kunisuke
authors.initials: K
authors.lastname: Izawa
authors.forename: Erik
authors.initials: E
authors.lastname: De Clercq
authors.forename: Johan
authors.initials: J
authors.lastname: Neyts
authors.forename: Jerzy
authors.initials: J
authors.lastname: Boryski
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003562:Cytidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D016174:Hepacivirus / Q000187:drug effects; D015005:Yellow fever virus / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D003562:Cytidine