title: In vitro activity of compounds isolated from Piper crassinervium against Trypanosoma cruzi.
abstract: This study describes the antichagasic potential of five compounds isolated from leaves of Piper crassinervium (Piperaceae). Two prenylated benzoic acid derivatives, one prenylated hydroquinone and two flavanones, were evaluated. The in vitro trypanocidal activity was determined against epimastigote forms of Trypanosoma cruzi (Y strain), the etiologic agent of Chagas disease. The most active compound was the prenylated hydroquinone [1,4-dihydroxy-2-(3(0),7(0)-dimethyl-1(0)-oxo-2(0)-E,6(0)-octadienyl)benzene] with an IC(50) value of 6.10 microg mL(-1), which was in the same order of activity if compared with the positive control benznidazole (IC(50) = 1.60 microg mL(-1)). This is the first report of trypanocidal activity for prenylated hydroquinone and benzoic acid derivatives.
authors.affiliation: Instituto de Quimica, Universidade Estadual Paulista, Araraquara, SP, Brazil.
authors.forename: Adriana Aparecida
authors.initials: AA
authors.lastname: Lopes
authors.forename: Silvia Noelí
authors.initials: SN
authors.lastname: López
authors.forename: Luis Octávio
authors.initials: LO
authors.lastname: Regasini
authors.forename: João Marcos Batista
authors.initials: JM
authors.lastname: Junior
authors.forename: Daniela Luz
authors.initials: DL
authors.lastname: Ambrósio
authors.forename: Massuo Jorge
authors.initials: MJ
authors.lastname: Kato
authors.forename: Vanderlan
authors.initials: V
authors.lastname: da Silva Bolzani
authors.forename: Regina Maria Barretto
authors.initials: RM
authors.lastname: Cicarelli
authors.forename: Maysa
authors.initials: M
authors.lastname: Furlan
mesh_terms: D000818:Animals; D031701:Piper / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D014344:Trypanocidal Agents / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects*
chemical_list: D010936:Plant Extracts; D014344:Trypanocidal Agents