Apoptotic and non-apoptotic programmed cardiomyocyte death in ventricular remodelling.
A defining cellular event in the transition from compensated hypertrophy to dilated cardiomyopathy is cardiomyocyte drop-out due to apoptosis, programmed necrosis, and autophagy. The importance of apoptosis in heart failure has been recognized for over a decade, while other forms of programmed cell death have more recently been appreciated, and their pathophysiological roles continue to be defined in experimental and clinical heart failure. The major focus of this review is on apoptosis in heart failure, with a discussion of molecular cross-talk between apoptosis, autophagy, and programmed necrosis.
Dorn
Gerald W
GW
Center for Pharmacogenomics and Cardiovascular Division, Department of Internal Medicine, Washington University, 660 S. Euclid Ave., Campus Box 8086, St Louis, MO 63110, USA. gdorn@dom.wustl.ed
D000818:Animals; D017209:Apoptosis; D001343:Autophagy; D006332:Cardiomegaly / Q000473:pathology / Q000503:physiopathology; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006333:Heart Failure / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000378:metabolism; D017202:Myocardial Ischemia / Q000473:pathology / Q000503:physiopathology; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000473:pathology*; D009336:Necrosis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D015398:Signal Transduction; D013312:Stress, Physiological; D020257:Ventricular Remodeling
D008565:Membrane Proteins; D024101:Mitochondrial Proteins; C501741:Nix protein, mouse; D019253:Proto-Oncogene Proteins c-bcl-2
J Cell Sci. 2002 Dec 15;115(Pt 24):4727-34
12432061
Curr Opin Cell Biol. 2005 Dec;17(6):617-25
16243507
Ann Med. 2007;39(8):594-607
17934906
J Mol Cell Cardiol. 2008 Mar;44(3):551-60
18178218
Cell. 1999 Apr 16;97(2):189-98
10219240
J Clin Invest. 2005 Aug;115(8):2108-18
16075055
J Clin Invest. 2005 Mar;115(3):527-37
15765134
J Am Coll Cardiol. 2004 Jan 21;43(2):295-301
14736452
Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6794-9
17420462
Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):8144-9
10393962
Nat Clin Pract Cardiovasc Med. 2006 Mar;3 Suppl 1:S8-13
16501638
J Biol Chem. 2002 Jun 21;277(25):22896-901
11943770
Nature. 2004 Dec 23;432(7020):1032-6
15525940
Circulation. 2005 Dec 13;112(24):3777-85
16344406
Cell. 2008 Jan 11;132(1):27-42
18191218
N Engl J Med. 1997 Apr 17;336(16):1131-41
9099657
J Pathol. 2003 Feb;199(2):229-36
12533836
Arch Biochem Biophys. 1979 Jul;195(2):468-77
112926
Circulation. 2003 Feb 25;107(7):984-91
12600911
Circulation. 1995 May 1;91(9):2314-8
7729016
J Clin Invest. 2007 Oct;117(10):2825-33
17909626
Cardiol Clin. 2001 Feb;19(1):113-26
11787805
Nature. 2007 Mar 22;446(7134):444-8
17334357
J Immunol. 2001 Mar 1;166(5):3130-42
11207265
EMBO Rep. 2005 Apr;6(4):321-6
15809659
Br J Cancer. 1993 Feb;67(2):205-8
8431353
Cell Struct Funct. 2002 Dec;27(6):421-9
12576635
Circ Res. 1997 Aug;81(2):137-44
9242174
Circ Res. 2002 Aug 9;91(3):226-31
12169648
Physiology (Bethesda). 2007 Feb;22:56-64
17289931
Oncogene. 2004 Apr 12;23(16):2766-73
15077140
Autophagy. 2006 Jul-Sep;2(3):212-4
16874110
Cell Death Differ. 2005 Nov;12 Suppl 2:1542-52
16247502
Circulation. 2005 Aug 30;112(9):1274-83
16129812
J Clin Invest. 2005 Mar;115(3):565-71
15765138
Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14495-500
16983089
Nat Clin Pract Cardiovasc Med. 2006 Dec;3(12):681-8
17122801
Arch Biochem Biophys. 1979 Jul;195(2):460-7
38751
Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5156-60
9560245
J Exp Med. 1997 Apr 21;185(8):1481-6
9126928
Am J Physiol Heart Circ Physiol. 2001 May;280(5):H2313-20
11299236
J Clin Invest. 2007 Sep;117(9):2431-44
17694179
Circulation. 2007 Jun 26;115(25):3197-204
17562954
Science. 2003 Apr 4;300(5616):65-7
12677047
Circulation. 1999 Nov 9;100(19 Suppl):II369-75
10567332
Am J Pathol. 1995 Jun;146(6):1325-31
7778672
Circ Res. 2004 Dec 10;95(12):1200-6
15539635
Nature. 2001 Mar 29;410(6828):549-54
11279485
J Pharmacol Sci. 2006;100(5):315-22
16552170
Cell. 1995 Aug 11;82(3):415-24
7634331
N Engl J Med. 1996 Oct 17;335(16):1190-6
8815941
N Engl J Med. 1996 Oct 17;335(16):1182-9
8815940
Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13807-12
16174725
Cell Death Differ. 2007 Jan;14(1):146-57
16645637
Nat Rev Mol Cell Biol. 2008 Jan;9(1):47-59
18097445
J Card Fail. 2002 Dec;8(6 Suppl):S512-7
12555167
Circ Res. 2008 Feb 29;102(4):472-9
18096822
Circulation. 2003 Dec 16;108(24):3036-41
14638549
Nat Cell Biol. 2003 Feb;5(2):97-9
12563272
J Biol Chem. 2005 Nov 18;280(46):38505-12
16061478
Prog Cardiovasc Dis. 1974 Jul-Aug;17(1):73-86
4599470
Recent Adv Stud Cardiac Struct Metab. 1976 May 26-29;12:453-63
1032000
Nature. 1999 Feb 4;397(6718):441-6
9989411
Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10140-5
9707614
Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12825-30
12226479
N Engl J Med. 2005 Jun 9;352(23):2413-23
15944426
J Clin Invest. 1975 Jul;56(1):56-64
124746
Nat Rev Immunol. 2005 Mar;5(3):189-200
15719025
Trends Cardiovasc Med. 2005 Jul;15(5):185-9
16165015
Arch Biochem Biophys. 1979 Jul;195(2):453-9
383019
Cardiovasc Res. 2005 Jun 1;66(3):454-61
15914110
J Clin Invest. 2007 Sep;117(9):2692-701
17694177
Cell Death Differ. 2005 Sep;12(9):1240-54
16094404
Circ Res. 2005 Nov 11;97(10):1009-17
16210547
Nature. 2001 Jul 5;412(6842):95-9
11452314
Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):8121-6
9223325
J Clin Invest. 2005 Mar;115(3):572-83
15765139
Nat Rev Mol Cell Biol. 2005 Jun;6(6):505-10
15928714
Curr Pharm Des. 2003;9(9):707-14
12570788
Cell. 2004 Jan 23;116(2):205-19
14744432
Cell Metab. 2007 May;5(5):326-7
17488635
Nature. 2000 Jan 6;403(6765):98-103
10638761
Nat Clin Pract Cardiovasc Med. 2005 Dec;2(12):628-38
16306919
Circ Res. 2000 Feb 18;86(3):255-63
10679475
Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):7614-6
10393865
Circulation. 2008 Jan 22;117(3):396-404
18178777
Nat Cell Biol. 2001 Nov;3(11):E255-63
11715037
Lancet. 2006 Jan 28;367(9507):356-67
16443044
Circulation. 1999 Jun 15;99(23):3071-8
10368127
Circ Res. 1998 Jul 13;83(1):15-26
9670914
Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6252-6
11972044
Science. 2003 Apr 4;300(5616):135-9
12624178
Trends Cell Biol. 2004 Apr;14(4):184-93
15066636
EMBO J. 2004 Sep 1;23(17):3559-69
15297879
J Cell Biochem. 2001;82(4):634-46
11500941
Physiol Rev. 2007 Oct;87(4):1285-342
17928585
J Biol Chem. 2006 Jan 20;281(3):1442-8
16291751
Mol Cell Biol. 2000 Aug;20(15):5454-68
10891486
Circulation. 2007 Mar 20;115(11):1456-63
17372187
Circulation. 2006 Jul 4;114(1 Suppl):I79-86
16820650
Circulation. 2006 Sep 5;114(10):1020-7
16923753
Am J Cardiol. 1988 Sep 9;62(8):94E-98E
2970785
Physiol Rev. 1992 Apr;72(2):369-417
1372998
Circ Res. 1999 Dec 9;85(12):e70-7
10590251
Circ Res. 2000 Nov 10;87(10):856-64
11073880
FEBS Lett. 2002 Feb 13;512(1-3):1-7
11852041
Circ Res. 2006 Dec 8;99(12):1347-54
17082476
J Clin Invest. 2005 Oct;115(10):2679-88
16200202
Oncogene. 2004 Apr 12;23(16):2785-96
15077142
Am J Physiol Heart Circ Physiol. 2006 Jul;291(1):H1-H19
16501026
Circ Res. 2003 Apr 18;92(7):715-24
12649263
Nature. 2008 Jul 10;454(7201):232-5
18454133
Nat Rev Mol Cell Biol. 2002 Jun;3(6):401-10
12042762
J Biol Chem. 1999 Jan 1;274(1):7-10
9867803
Genes Dev. 1999 Aug 1;13(15):1899-911
10444588
Nat Med. 2002 Jul;8(7):725-30
12053174
J Am Coll Cardiol. 1992 Jun;19(7):1622-33
1350597
J Am Coll Cardiol. 2000 Jun;35(7):1769-77
10841223
Am J Pathol. 2008 Jul;173(1):2-13
18535182