title: Zirconocene-mediated synthesis of cyclobutabenzenes.
abstract: A new, mild, one-pot method for the synthesis of cyclobutabenzenes by the zirconium-promoted cross-coupling reaction of aryllithium compounds and alkenyl bromides is reported. Formation of an arynezirconocene complex and its regioselective coupling with an alkenyl bromide are the key steps of the process. This method allows the regio- and diastereoselective synthesis of functionalized cyclobutabenzene derivatives from simple and easily available starting materials.
authors.affiliation: Instituto Universitario de Química Organometálica Enrique Moles, Unidad Asociada al CSIC, Universidad de Oviedo, Julián Clavería 8, 33006-Oviedo, Spain. barluenga@uniovi.es
authors.forename: José
authors.initials: J
authors.lastname: Barluenga
authors.forename: Jonás
authors.initials: J
authors.lastname: Calleja
authors.forename: María J
authors.initials: MJ
authors.lastname: Antón
authors.forename: Lucía
authors.initials: L
authors.lastname: Alvarez-Rodrigo
authors.forename: Félix
authors.initials: F
authors.lastname: Rodríguez
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Fañanás
mesh_terms: D001554:Benzene / Q000138:chemical synthesis* / Q000737:chemistry; D003503:Cyclobutanes / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D015040:Zirconium / Q000737:chemistry*
chemical_list: D003503:Cyclobutanes; D009942:Organometallic Compounds; C023398:Zirconocene dichloride; D015040:Zirconium; D001554:Benzene