A click chemistry approach towards nucleic acid major groove functionalization.
A synthetic strategy towards new aromatic nucleoside derivatives introducing additional aromatic functionality placed in the major groove of a modified DNA duplex is presented. The functionalities are introduced using Click Chemistry conditions and found to increase the overall duplex stability.
Andersen
Nicolai K
NK
Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, 5230 Odense M, Denmark.
Spácilová
Lucie
L
Jensen
Michael D
MD
Kocalka
Petr
P
Jensen
Frank
F
Nielsen
Poul
P
D001671:Biochemistry / Q000379:methods; D004247:DNA / Q000737:chemistry*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry
D011741:Pyrimidine Nucleosides; D004247:DNA