title: Effect of cationic comb-type copolymer on the B-Z transition of poly(dG-dC).poly(dG-dC).
abstract: The structural transition of a double helical DNA from B-DNA to Z-DNA, B-Z transition, has been received growing attention because of its potential roles in biological systems and its applicability to nanobiotechnology. It was known that the B-Z transition is induced by cationic molecules. However, there are only a few reports describing cationic polymers as potential B-Z inducers. In this study, we demonstrated that cationic comb-type copolymer, poly(L-lysine)-graft-dextran, induced the B-Z transition in which distinct intermediate formation was involved. Furthermore, we suggested that the grafted-dextran plays an important role in the B-Z transition.
authors.affiliation: Institute for Materials Chemistry and Engineering, Kyushu University, Motooka 744, Nishi-ku, Fukuoka 819-8581, Japan.
authors.forename: Naohiko
authors.initials: N
authors.lastname: Shimada
authors.forename: Arihiro
authors.initials: A
authors.lastname: Kano
authors.forename: Atsushi
authors.initials: A
authors.lastname: Maruyama
mesh_terms: D002942:Circular Dichroism; D043542:DNA, Z-Form / Q000737:chemistry*; D003911:Dextrans / Q000737:chemistry*; D011089:Polydeoxyribonucleotides / Q000737:chemistry*; D011107:Polylysine / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D043542:DNA, Z-Form; D003911:Dextrans; D011089:Polydeoxyribonucleotides; C113090:poly(lysine)-graft-dextran; D011107:Polylysine; C019530:poly(dC-dG)