title: Morphological study of acute zonal occult outer retinopathy (AZOOR) by multiplanar optical coherence tomography.
abstract: OBJECTIVE
  We set out to determine whether morphological retinal changes occur in patients with acute zonal occult outer retinopathy (AZOOR).
  
  
  METHODS
  Five patients diagnosed with AZOOR were studied. They included two men and three women, with an age range of 23-51 years. Symptoms and findings were retrospectively and prospectively collected. The three-dimensional multiplanar optical coherence tomography (OCT) Ophthalmoscope was used to examine the morphology of the retina in patients who were examined between April 2000 to December 2004. Standardized full-field electroretinograms (ERGs) and multifocal ERGs (mfERGs) were recorded.
  
  
  RESULTS
  All the patients reported an acute onset of visual disturbances including a decrease of central vision and photopsia. The a- and b-waves of full-field ERGs were decreased, and the mfERGs in the central area were reduced. Ophthalmoscopic examination showed no obvious fundus abnormalities. OCT Ophthalmoscopic images of a cross-sectional plane revealed hyporeflection at the level of the photoreceptor layer in the macular region in three of five patients, and presence of one or two layers in which the inner/outer segment junction of the photoreceptor layer was absent in the other two patients. En-face, constant depth C-scans, which present the image parallel to the retina, revealed an abnormal, patchy hyper-reflection in the affected eyes of two patients and in the non-affected eye in one of these two patients.
  
  
  CONCLUSIONS
  The changes in OCT Ophthalmoscope B-scan images indicate morphological damage to the photoreceptors, which probably accounts for the functional alterations. The alterations in the C-scan image in the normal fellow eye of one patient suggest that morphological changes may precede symptomatic changes.
authors.affiliation: Department of Ophthalmology, Asahikawa Medical Collage, Asahikawa, Japan. ytakai@med.nagoya-u.ac.jp
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Takai
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ishiko
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kagokawa
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Fukui
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takahashi
authors.forename: Akitoshi
authors.initials: A
authors.lastname: Yoshida
mesh_terms: D000208:Acute Disease; D000328:Adult; D004596:Electroretinography; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000295:instrumentation; D008297:Male; D008875:Middle Aged; D019721:Ophthalmoscopes; D020419:Photoreceptor Cells, Vertebrate / Q000473:pathology; D011446:Prospective Studies; D012164:Retinal Diseases / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000295:instrumentation; D014786:Vision Disorders / Q000209:etiology; D014794:Visual Fields; D055815:Young Adult