Pulmonary haemorrhage associated with neonatal neurological disease.
Pulmonary haemorrhage (PH) following a neurological insult is referred to as neurogenic pulmonary haemorrhage. This entity has not been described in neonates. We conducted a retrospective study of 50 neonates with PH, with and without a preceding neurological insult. Among 10/22 neonates with a preceding neurological insult, no other predisposing factor or factor associated with PH was identified. Although we speculate that in some neonates, PH may have a neurogenic origin, similar to that described in older patients, a more detailed prospective study is required. Such a prospective study requires sufficient patient numbers and clinical measures to permit a statistically powered analysis of the risk of developing a PH in those with and without neurological injury before we can confidently assert that a neurogenic injury has a causative role in PH.
Lodha
Abhay
A
Division of Neonatology, Department of Pediatrics, The Hospital for Sick Children and University of Toronto, Toronto, Canada. abhay.lodha@calgaryhealthregion.ca
Shah
Prakesh S
PS
Hellmann
Jonathan
J
D005260:Female; D006470:Hemorrhage / Q000209:etiology* / Q000401:mortality; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases; D008171:Lung Diseases / Q000209:etiology* / Q000401:mortality; D008297:Male; D009422:Nervous System Diseases / Q000150:complications* / Q000401:mortality; D011446:Prospective Studies; D012189:Retrospective Studies