Putative mechanisms of the relationship between obesity and migraine progression.
Studies suggest that obesity is associated with migraine progression from an episodic into a chronic form. We discuss putative mechanisms to justify this relationship. Several of the inflammatory mediators that are increased in obese individuals are important in migraine pathophysiology, including interleukins and calcitonin gene-related peptide. Both migraine and obesity are prothrombotic states. Substances that are important in metabolic control are nociceptive at certain levels. Hypothalamic dysfunction in the orexin pathways seems to be a risk factor for both conditions. In addition, we discuss the importance of metabolic syndrome and autonomic dysfunction in modulating the obesity/migraine progression relationship.
Bigal
Marcelo E
ME
Global Director for Scientific Affairs, Merck Research Laboratories, Whitehouse Station, NJ 08889, USA. marcelo_bigal@merck.com
Lipton
Richard B
RB
D000818:Animals; D002908:Chronic Disease; D018450:Disease Progression; D006801:Humans; D008881:Migraine Disorders / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology*; D009765:Obesity / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology*
Arch Intern Med. 2007 Oct 8;167(18):1964-70
17923596
Ann Neurol. 1993 Jan;33(1):48-56
8388188
Atherosclerosis. 2006 Sep;188(1):190-5
16313909
Neurology. 2006 Feb 28;66(4):545-50
16354886
J Clin Invest. 2004 May;113(10):1447-55
15146242
Eur J Haematol. 2006 Jun;76(6):516-20
16696775
Headache. 2006 Feb;46(2):200-7
16492228
Headache. 2006 Feb;46(2):197-9
16492227
Circulation. 2003 May 6;107(17):2190-5
12695289
Headache. 1998 Jul-Aug;38(7):497-506
15613165
Neurology. 1993 Jun;43(6 Suppl 3):S16-20
8389008
Pain. 2004 Jun;109(3):367-378
15157698
Brain Res. 1985 Mar 11;329(1-2):285-8
2983841
Headache. 1982 Nov;22(6):284-6
7174306
Pediatr Endocrinol Rev. 2004 Aug;1 Suppl 3:476-83
16444178
Clin Endocrinol (Oxf). 2006 Apr;64(4):355-65
16584505
Int J Obes Relat Metab Disord. 1998 Dec;22(12):1145-58
9877249
Int J Cardiol. 2007 Oct 31;122(1):29-33
17188378
Headache. 2005 Apr;45 Suppl 1:S3-S13
15833088
Neurology. 2007 May 22;68(21):1851-61
17515549
Health Aff (Millwood). 2003 Jan-Jun;Suppl Web Exclusives:W3-219-26
14527256
JAMA. 2006 Jan 11;295(2):190-8
16403931
Neurology. 1996 Oct;47(4):871-5
8857711
Cerebrovasc Brain Metab Rev. 1993 Fall;5(3):159-77
8217498
JAMA. 2006 Jul 19;296(3):283-91
16849661
Neurology. 2006 Jul 25;67(2):252-7
16864817
Neuro Endocrinol Lett. 2005 Aug;26(4):293-6
16135994
Cephalalgia. 2005 Jan;25(1):12-5
15606564
Neurology. 2003 Apr 22;60(8):1308-12
12707434
Annu Rev Psychol. 2004;55:125-48
14744212
Diabetologia. 2006 Apr;49(4):744-7
16496121
Headache. 2004 Jan;44(1):53-64
14979884
Int J Obes (Lond). 2007 Jan;31(1):177-88
16652128
Brain Res. 2005 May 17;1044(1):76-86
15862792
FEBS Lett. 2006 May 22;580(12):2917-21
16674947
Arq Neuropsiquiatr. 2005 Dec;63(4):931-3
16400407
Am J Med. 2006 May;119(5 Suppl 1):S3-9
16563945
Metabolism. 2007 Jan;56(1):87-93
17161230
Cephalalgia. 1998 Nov;18(9):618-21; discussion 591
9876885
Pain. 2003 Nov;106(1-2):81-9
14581114
Cell. 1995 Jan 13;80(1):15-8
7813011
Headache. 1987 Feb;27(2):102-6
3570762
J Pharmacol Exp Ther. 2005 Dec;315(3):1380-5
16160082
Eur J Endocrinol. 2005 Dec;153(6):963-9
16322403
Neurology. 2005 Feb 22;64(4):614-20
15728281
Headache. 2007 Jun;47(6):866-75
17578537