title: Non-Newtonian bile flow in elastic cystic duct: one- and three-dimensional modeling.
abstract: Bile flow is thought to play an essential role in the pathophysiological genesis of cholelithiasis (gallstone formation) and in gallbladder pain. In this paper, we extend our previous study of the human biliary system (Li et al., 2007, J. Biomech. Eng., 129:164-173) to include two important factors: the non-Newtonian properties of bile, and elastic deformation of the cystic duct. A one-dimensional (1D) model is analyzed and compared with three-dimensional (3D) fluid-structure interaction simulations. It is found that non-Newtonian bile raises resistance to the flow of bile, which can be augmented significantly by the elastic deformation (collapse) of the cystic duct. We also show that the 1D model predicts the pressure drop of the cystic duct flow well for all cases considered (Newtonian or non-Newtonian flow, rigid or elastic ducts), when compared with the full 3D simulations.
authors.affiliation: Department of Mathematics, University of Glasgow, Glasgow G128QW, UK.
authors.forename: W G
authors.initials: WG
authors.lastname: Li
authors.forename: X Y
authors.initials: XY
authors.lastname: Luo
authors.forename: S B
authors.initials: SB
authors.lastname: Chin
authors.forename: N A
authors.initials: NA
authors.lastname: Hill
authors.forename: A G
authors.initials: AG
authors.lastname: Johnson
authors.forename: N C
authors.initials: NC
authors.lastname: Bird
mesh_terms: D001646:Bile / Q000502:physiology*; D001696:Biomechanical Phenomena; D003549:Cystic Duct / Q000503:physiopathology*; D005704:Gallbladder / Q000503:physiopathology*; D042882:Gallstones / Q000503:physiopathology; D006801:Humans; D008954:Models, Biological