Development of A3 adenosine receptor ligands.
4'-Thioadenosines have been discovered as novel templates for A(3) adenosine ligands. Among these, 4'-thioadenosine-5'-monoalkyluronamides were discovered as novel potent and selective A(3) adenosine receptor agonists, while 4'-thioadenosine-5'-dialkyluronamides and truncated 4'-thioadenosine derivatives exhibited potent and selective antagonism at the A(3) adenosine receptor.
Jeong
Lak Shin
LS
Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea. lakjeong@ewha.ac.kr
D000241:Adenosine / Q000031:analogs & derivatives*; D058909:Adenosine A3 Receptor Agonists; D058918:Adenosine A3 Receptor Antagonists; D006801:Humans; D008024:Ligands; D013872:Thionucleosides / Q000737:chemistry* / Q000494:pharmacology
D058909:Adenosine A3 Receptor Agonists; D058918:Adenosine A3 Receptor Antagonists; D008024:Ligands; D013872:Thionucleosides; D000241:Adenosine