Association between serum retinol-binding protein 4 and small dense low-density lipoprotein cholesterol levels in young adult women.
BACKGROUND
Serum retinol-binding protein 4 (RBP4) and small dense low-density lipoprotein (sdLDL) have been suggested to be associated with insulin resistance, but no information is available on the relationship between RBP4 and sdLDL.


METHODS
We determined serum RBP4, sdLDL-cholesterol, and other metabolic variables on 38 young women, aged 19-29 years. The homeostatic model assessment of insulin resistance (HOMA-IR) was used for the estimation of insulin resistance.


RESULTS
In simple regression analyses, RBP4 levels had significant correlations with total cholesterol (r=0.354, P=0.029), LDL-cholesterol (r=0.396, P=0.014), and sdLDL-cholesterol (r=0.510, P=0.001) levels. The sdLDL-cholesterol levels also correlated significantly with total cholesterol (r=0.402, P=0.012), LDL-cholesterol (r=0.627, P<0.001) and triglycerides (r=0.449, P=0.005). Stepwise multiple regression analyses showed only sdLDL-cholesterol (beta coefficient (ss)=0.510, P=0.001) level was a significant independent predictor of RBP4 levels (adjusted R(2)=0.240), whereas RBP4 (ss=0.289, P=0.026) level was one of major factors affecting sdLDL-cholesterol levels (adjusted R(2)=0.519). There was no significant association of HOMA-IR with RBP4 or sdLDL levels.


CONCLUSIONS
We showed an independent linkage between serum RBP4 and sdLDL-cholesterol levels in young adult women. These findings may contribute to understanding of lipoprotein metabolisms involved in diabetes and cardiovascular disease.
Usui
Shinichi
S
Department of Medical Technology, Okayama University Graduate School of Health Sciences, Okayama, Japan.
Ichimura
Mitsuko
M
Ikeda
Satoru
S
Okamoto
Motoi
M
D000328:Adult; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000473:pathology; D008078:Cholesterol, LDL / Q000097:blood*; D003920:Diabetes Mellitus / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D012044:Regression Analysis; D054839:Retinol-Binding Proteins, Plasma / Q000032:analysis / Q000378:metabolism*; D055815:Young Adult
D008078:Cholesterol, LDL; C101326:RBP4 protein, human; D054839:Retinol-Binding Proteins, Plasma