Brain-derived neurotrophic factor gene variation influences cerebrospinal fluid 3-methoxy-4-hydroxyphenylglycol concentrations in healthy volunteers.
Brain-derived neurotrophic factor (BDNF) has been shown to influence monoamine transmitter synthesis, metabolism and release. We investigated possible relationships between four BDNF gene polymorphisms and cerebrospinal fluid (CSF) concentrations of 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) in healthy volunteers (n = 132). All BDNF polymorphisms (270 C/T, -633 T/A, Val66Met, and 11757 G/C) were associated with MHPG (P < 0.02), but not with 5-HIAA and HVA concentrations. At a second clinical investigation 8-20 years after CSF sampling 30% of the subjects had experienced various psychiatric disorders. Development of a psychiatric disorder was predicted by low 5-HIAA concentrations (P = 0.01). The results suggest that BDNF gene variation participates in regulation of norepinephrine turnover rates in the central nervous system of human subjects.
Jönsson
Erik G
EG
Department of Clinical Neuroscience, Karolinska Institute and Hospital, Stockholm, Sweden. erik.jonsson@ki.se
Saetre
Peter
P
Edman-Ahlbom
Bodil
B
Sillén
Anna
A
Gunnar
Agneta
A
Andreou
Dimitrios
D
Agartz
Ingrid
I
Sedvall
Göran
G
Hall
Håkan
H
Terenius
Lars
L
D000328:Adult; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry / Q000235:genetics; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005820:Genetic Testing; D005838:Genotype; D006719:Homovanillic Acid / Q000032:analysis / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000032:analysis / Q000134:cerebrospinal fluid; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000032:analysis / Q000134:cerebrospinal fluid*; D019965:Neurocognitive Disorders / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D009638:Norepinephrine / Q000378:metabolism*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011237:Predictive Value of Tests; D012701:Serotonin / Q000378:metabolism; D055815:Young Adult
D019208:Brain-Derived Neurotrophic Factor; D012701:Serotonin; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D009638:Norepinephrine; D006719:Homovanillic Acid
Eur Arch Psychiatry Clin Neurosci. 1994;244(1):26-32
7918698
Brain Res. 1994 Sep 5;656(1):147-56
7804829
Science. 2002 Jun 21;296(5576):2225-9
12029063
Dev Biol. 1995 Jul;170(1):169-82
7601307
Acta Psychiatr Scand. 1985 Mar;71(3):230-6
2580421
J Psychiatr Res. 2000 May-Jun;34(3):239-44
10867119
Exp Neurol. 1995 May;133(1):50-63
7601263
Prog Neuropsychopharmacol Biol Psychiatry. 2006 Jul;30(5):924-33
16581172
Arch Gen Psychiatry. 1976 Oct;33(10):1193-7
971028
Eur J Neurosci. 2005 Apr;21(7):2019-23
15869495
Biol Psychiatry. 2001 Nov 15;50(10):783-91
11720697
J Neurosci. 2002 May 15;22(10):4153-62
12019333
Exp Neurol. 1999 Dec;160(2):500-7
10619567
Cell. 2003 Jan 24;112(2):257-69
12553913
J Clin Psychiatry. 1990 Apr;51 Suppl:31-41; discussion 42-3
1691169
Mol Psychiatry. 2001 Jan;6(1):83-6
11244490
Pain. 2008 Jun;136(3):348-355
17822849
Mol Psychiatry. 2002;7(6):579-93
12140781
Alcohol. 1985 May-Jun;2(3):415-8
2411275
Biol Psychiatry. 1996 Nov 15;40(10):1032-43
8915563
Acta Psychiatr Scand. 1984 Mar;69(3):201-19
6201041
Bioinformatics. 2005 Aug 15;21(16):3445-7
15947021
Int J Obes Relat Metab Disord. 2001 Sep;25(9):1286-93
11571589
Genes Brain Behav. 2007 Nov;6(8):706-16
17376155
J Psychiatr Res. 1986;20(1):19-29
2423688
Prog Neuropsychopharmacol Biol Psychiatry. 2001 May;25(4):691-707
11383973
Eur J Neurosci. 1995 Feb 1;7(2):223-33
7757259
Int J Exp Diabetes Res. 2001;2(3):201-9
12369708
BMC Psychiatry. 2004 Mar 04;4:4
15102340
Bioinformatics. 2005 Jan 15;21(2):263-5
15297300
Arch Gen Psychiatry. 1980 Oct;37(10):1113-6
6158928
Psychopharmacology (Berl). 1976 Jul 28;48(2):147-53
826926
Psychiatry Res. 2003 Jan 20;122(1):21-35
12589880
Brain Res Dev Brain Res. 1994 Sep 16;81(2):318-24
7813052