Synthesis and biological evaluation of 5''-iodoneplanocin A and its analogues.
5''-Iodoneplanocin A was enantiopurely synthesized as potential antiviral and antitumor agents starting from D-ribose using an addition-iodination-elimination reaction, a RCM reaction and an oxidative rearrangement.
Park
Ah-Young
AY
College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan 609-735, Korea.
Kim
Kyung Ran
KR
Lee
Hyung-Rock
HR
Kang
Jin-Ah
JA
Kim
Won Hee
WH
Jeong
Lak Shin
LS
Moon
Hyung Ryong
HR
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011684:Purine Nucleosides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
C541638:5''-iodoneplanocin A; D000998:Antiviral Agents; D011684:Purine Nucleosides; D000241:Adenosine