A new linker group for functionalization of nucleic acids.
A new linker bearing two orthogonal precursor groups - an amino group for the reaction with electrophilic agents, and also a terminal triple bond for the reaction with an aliphatic azido group (1,3-dipolar cycloaddition reaction) for the introduction of the different residues into nucleosides is designed and synthesized. 5'-Triphosphates of various nucleosides bearing proposed linker group have been obtained.
Vasileva
Svetlana
S
Institute of Chemical Biology & Fundamental Medicine, Lavrentev Ave, 8, Novosibirsk, 630090 Russia. Vasilieva_2001@mail.ru
Konevetz
Dmitrii
D
Budilkin
Boris
B
Abramova
Tatiana
T
Kasatkina
Nina
N
Silnikov
Vladimir
V
D000081:Acetamides / Q000138:chemical synthesis / Q000737:chemistry; D003845:Deoxycytosine Nucleotides / Q000737:chemistry; D003853:Deoxyribonucleosides / Q000737:chemistry*; D003854:Deoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry; D015224:Dideoxynucleosides / Q000737:chemistry; D004987:Ethers / Q000138:chemical synthesis / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010797:Phthalimides / Q000138:chemical synthesis / Q000737:chemistry*
D000081:Acetamides; D003845:Deoxycytosine Nucleotides; D003853:Deoxyribonucleosides; D003854:Deoxyribonucleotides; D015224:Dideoxynucleosides; D004987:Ethers; C541626:N-3-phthalimidopropyl progargyl ether; D010797:Phthalimides; C541627:propynyloxypropyl trifluoroacetamide; C024107:2'-deoxycytidine 5'-triphosphate