title: Total synthesis of hyacinthacine A1, a glycosidase inhibitor.
abstract: A practical and enantioselective total synthesis of hyacinthacine A1 is achieved involving syn allylic epoxide opening with retention using Pd catalysis and "domino" hydrogenation (five steps in one pot) sequences.
authors.affiliation: Organic Division-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India. srivaric@iict.res.in
authors.forename: Srivari
authors.initials: S
authors.lastname: Chandrasekhar
authors.forename: Bibhuti Bhusan
authors.initials: BB
authors.lastname: Parida
authors.forename: Chegondi
authors.initials: C
authors.lastname: Rambabu
mesh_terms: D002384:Catalysis; D004852:Epoxy Compounds; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors*; D006865:Hydrogenation; D010165:Palladium; D011763:Pyrrolizidine Alkaloids / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D004852:Epoxy Compounds; D011763:Pyrrolizidine Alkaloids; C508850:hyacinthacine A1; D010165:Palladium; D006026:Glycoside Hydrolases