Two new patients with Curry-Jones syndrome with trichoblastoma and medulloblastoma suggest an etiologic role of the sonic hedgehog-patched-GLI pathway.
Curry-Jones syndrome (OMIM #601707) is a rare multiple malformation disorder of unknown etiology, associated with brain and skull abnormalities, polysyndactyly, and defects of the eyes, skin and gastrointestinal tract. We report on two new cases of Curry-Jones syndrome with previously unreported features, including benign and malignant neoplasms. The first patient had typical features of Curry-Jones syndrome as well as multiple intra-abdominal smooth muscle hamartomas and trichoblastoma of the skin. The second patient was born with occipital meningoceles and developed a desmoplastic medulloblastoma. Routine lymphocyte karyotype, GLI3 gene analysis and Patched (PTCH) gene analysis on both patients and chromosome microarray analysis on the first patient were normal. We review the previously reported cases of Curry-Jones syndrome and compare our patients' findings. In view of the association of trichoblastoma with basal cell carcinoma and desmoplastic medulloblastoma with nevoid basal cell carcinoma syndrome (NBCCS) and PTCH mutations, we hypothesize that Curry-Jones syndrome is caused by malfunction of an element in the sonic hedgehog pathway.
Grange
Dorothy K
DK
Division of Genetics and Genomic Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110, USA. grange_d@kids.wustl.edu
Clericuzio
Carol L
CL
Bayliss
Susan J
SJ
Berk
David R
DR
Heideman
Richard L
RL
Higginson
Julie K
JK
Julian
Stephanie
S
Lind
Anne
A
D000015:Abnormalities, Multiple / Q000209:etiology / Q000235:genetics / Q000473:pathology; D061085:Agenesis of Corpus Callosum; D001932:Brain Neoplasms / Q000209:etiology / Q000473:pathology; D002675:Child, Preschool; D003103:Coloboma / Q000209:etiology / Q000473:pathology; D005260:Female; D041981:Gastrointestinal Tract / Q000002:abnormalities; D006222:Hamartoma / Q000209:etiology / Q000473:pathology; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology; D007223:Infant; D051741:Kruppel-Like Transcription Factors / Q000235:genetics / Q000378:metabolism; D008297:Male; D008527:Medulloblastoma / Q000209:etiology / Q000473:pathology; D008588:Meningocele / Q000209:etiology / Q000473:pathology; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D000072079:Patched Receptors; D000072081:Patched-1 Receptor; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism; D012878:Skin Neoplasms / Q000209:etiology / Q000473:pathology; D012886:Skull / Q000002:abnormalities; D013576:Syndactyly / Q000209:etiology / Q000473:pathology; D013577:Syndrome; D000074290:Zinc Finger Protein Gli3
C065683:GLI3 protein, human; D051741:Kruppel-Like Transcription Factors; D009419:Nerve Tissue Proteins; C000606236:PTCH1 protein, human; D000072079:Patched Receptors; D000072081:Patched-1 Receptor; D011956:Receptors, Cell Surface; D000074290:Zinc Finger Protein Gli3