Effects of dietary conjugated linoleic acid in advanced experimental polycystic kidney disease.
OBJECTIVE
Several dietary interventions, including those involving conjugated linoleic acid (CLA), slow progression of polycystic kidney disease (PKD) when initiated in the early stages of disease in Han:SPRD-cy rats. However, in humans, kidney disease is often undetected until extensive renal injury has developed. The objective of this study therefore was to determine whether initiating dietary CLA intervention in advanced PKD would slow disease progression.


METHODS
Adult male Han:SPRD-cy rats with advanced kidney disease were fed diets with or without 1% CLA for 16 weeks. Disease progression was assessed by serum urea, proteinuria, and creatinine clearance, and morphological and immunohistochemical measurements for pathologic change.


RESULTS
Renal injury was lower in the PKD rats given CLA compared to those given the control diet as indicated by a reduction in inflammation (42% less), fibrosis (28% less), oxidative damage (30% less) and proliferating cells (35% less). Diet had no effect on body, kidney, or liver weight, serum urea, serum creatinine, creatinine clearance, proteinuria, or cyst volume.


CONCLUSIONS
Late dietary intervention with CLA reduced some disease-associated pathologies, but did not alter renal function in adult Han:SPRD-cy rats. The long-term anti-inflammatory, antioxidant, and antiproliferative benefits of CLA in advanced kidney disease remain to be determined.
Scatliff
Candice E
CE
Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
Bankovic-Calic
Neda
N
Ogborn
Malcolm R
MR
Aukema
Harold M
HM
D000818:Animals; D018450:Disease Progression; D044243:Linoleic Acids, Conjugated / Q000008:administration & dosage*; D008297:Male; D007690:Polycystic Kidney Diseases / Q000178:diet therapy* / Q000517:prevention & control*; D051381:Rats
D044243:Linoleic Acids, Conjugated