Study of association between atrophic gastritis and body mass index: a cross-sectional study in 10,197 Japanese subjects.
OBJECTIVE
The aim of this study was to elucidate the association between body mass index (BMI) and both Helicobacter pylori and atrophic gastritis.


METHODS
The study involved 10,197 subjects participating in a Japanese mass endoscopic gastric cancer screening program. Atrophic gastritis was assessed by pepsinogen I to II ratio.


RESULTS
In logistic regression models, BMI had an inverse association with atrophic gastritis, with the odds ratios (OR) decreasing progressively to 0.67 (95% confidence interval [CI] 0.57-0.79, P<0.0001) in the highest BMI quintiles (BMI >or=25.66) group compared with the lowest BMI quintiles (BMI <20.97) group. In linear regression models, atrophic gastritis predicted BMI (regression coefficient -0.326, 95% CI -0.469, -0.184, P<0.0001), whereas H. pylori antibody was not a predictor (regression coefficient 0.072, 95% CI -0.053, 0.198, P=0.3).


CONCLUSIONS
A small, inverse association between BMI and atrophic gastritis was found in the general population. In contrast, no association was observed between H. pylori seropositivity and BMI.
Watabe
Hirotsugu
H
Medical Sciences, Gardiner Institute, Western Infirmary, University of Glasgow, Glasgow G11 6NT, UK.
Mitsushima
Toru
T
Derakhshan
Mohammad H
MH
Yamaji
Yutaka
Y
Okamoto
Makoto
M
Kawabe
Takao
T
Omata
Masao
M
McColl
Kenneth E L
KE
D000328:Adult; D000367:Age Factors; D000907:Antibodies, Bacterial / Q000097:blood; D044466:Asian People / Q000706:statistics & numerical data; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D005757:Gastritis, Atrophic / Q000208:ethnology / Q000209:etiology / Q000503:physiopathology*; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000208:ethnology / Q000209:etiology / Q000382:microbiology / Q000503:physiopathology*; D016480:Helicobacter pylori / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D016017:Odds Ratio; D020116:Pepsinogen A / Q000097:blood; D020115:Pepsinogen C / Q000097:blood; D018570:Risk Assessment; D012307:Risk Factors
D000907:Antibodies, Bacterial; D020115:Pepsinogen C; D020116:Pepsinogen A
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