title: Synthesis and study of 9-deazaguanosine derivatives as potential inhibitors of RNA virus replication.
abstract: 9-Deazaguanosine and the alpha and beta anomers of its 2'-C-methyl counter part, have been synthesized and evaluated against a broad range of RNA viruses, including hepatitis C virus.
authors.affiliation: Idenix Pharmaceuticals, Medicinal Chemistry Laboratory, Cap Gamma 1682 rue de la Valsière, 34189 Montpellier Cedex 4, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Hamann
authors.forename: Claire
authors.initials: C
authors.lastname: Pierra
authors.forename: Richard
authors.initials: R
authors.lastname: Storer
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Sommadossi
authors.forename: Anna Giulia
authors.initials: AG
authors.lastname: Loi
authors.forename: Alessandra
authors.initials: A
authors.lastname: Cadeddu
authors.forename: Maura
authors.initials: M
authors.lastname: Fanti
authors.forename: Nadia
authors.initials: N
authors.lastname: Boscu
authors.forename: Fabiola
authors.initials: F
authors.lastname: Bassetti
authors.forename: Michel
authors.initials: M
authors.lastname: Liuzzi
authors.forename: Gilles
authors.initials: G
authors.lastname: Gosselin
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005416:Flavivirus / Q000187:drug effects; D006151:Guanosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D016174:Hepacivirus / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects
chemical_list: C541634:9-deazaguanosine; D000998:Antiviral Agents; D006151:Guanosine