A versatile synthetic approach for the development of libraries of 5', 3'-bis-conjugated oligonucleotides.
A versatile approach to develop libraries of diverse 5',3'-bis-conjugated oligonucleotides (ODNs) is here described. The usage of ad hoc derivatized solid supports, to which the first nucleoside unit is attached through a phosphate linkage, opens easy synthetic access to a large variety of hybrid bis-conjugated oligomers. The G-quadruplex forming d((5')TGGGAG(3')) sequence, as a potential anti-HIV agent, has been here used as a model system.
Di Fabio
Giovanni
G
Dipartimento di Chimica Organica e Biochimica, Università degli Studi di Napoli Federico II, Complesso Universitario di Monte S. Angelo, via Cinthia, 4, I-80126 Napoli, Italy. giovanni.difabio@unina.it
Coppola
Cinzia
C
D'Onofrio
Jennifer
J
De Napoli
Lorenzo
L
Montesarchio
Daniela
D
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry; D054856:G-Quadruplexes; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D054852:Small Molecule Libraries
D019380:Anti-HIV Agents; D009838:Oligodeoxyribonucleotides; D054852:Small Molecule Libraries