title: [Etiologic fraction and interaction of risk factors for primary hepatic carcinoma in Guangxi, China].
abstract: OBJECTIVE
  To explore etiologic fraction (EF) and interaction of hepatitis B virus (HBV) infection and other risk factors for primary hepatocellular carcinoma (PHC) in Guangxi, China.
  
  
  METHODS
  A hospital-based case-control study including 500 PHC patients and 500 nontumorous patients was carried out in Guangxi. EF and interactions of HBV infection and other risk factors for PHC were analyzed by crossover analysis and nonconditional multiple logistic regression.
  
  
  RESULTS
  HBV infection, family history of PHC, diabetes mellitus, eating raw fish, heavy alcohol consumption, frequently used drug, low income, mental oppression and blood type B all were risk factors for PHC. With EFs of 0.725, 0.186, 0.119, 0.486, 0.385, 0.438, 0.277, 0.607, 0.299, respectively and with etiologic fractions attributable to interaction [EF(A xB)] of 0.736, 0.643, 0.849, 0.551, 0.592, 0.618, 0.902, 0.577; and indices of interaction of 0.743, 0.651, 0.853, 0.560, 0.600, 0.626, 0.907, 0.586, respectively.
  
  
  CONCLUSIONS
  Main risk factors for PHC might include HBV infection, family history of PHC, diabetes mellitus, eating raw fish, heavy alcohol consumption, frequently used drug, low income, mental oppression and blood type B. HBV infection with other risk factors might exert synergistic action on developing PHC and increase the risk of PHC.
authors.affiliation: Department of Epidemiology, Public Health College, Guangxi Medical University, Nanning 530021, China.
authors.forename: Sheng-Kui
authors.initials: SK
authors.lastname: Tan
authors.forename: Xiao-Qiang
authors.initials: XQ
authors.lastname: Qiu
authors.forename: Hong-Ping
authors.initials: HP
authors.lastname: Yu
authors.forename: Xiao-Yun
authors.initials: XY
authors.lastname: Zeng
authors.forename: Zeng-Ming
authors.initials: ZM
authors.lastname: Xiao
authors.forename: Lang
authors.initials: L
authors.lastname: Hu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000209:etiology*; D002681:China / Q000453:epidemiology; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors