title: Study of association between atrophic gastritis and body mass index: a cross-sectional study in 10,197 Japanese subjects.
abstract: OBJECTIVE
  The aim of this study was to elucidate the association between body mass index (BMI) and both Helicobacter pylori and atrophic gastritis.
  
  
  METHODS
  The study involved 10,197 subjects participating in a Japanese mass endoscopic gastric cancer screening program. Atrophic gastritis was assessed by pepsinogen I to II ratio.
  
  
  RESULTS
  In logistic regression models, BMI had an inverse association with atrophic gastritis, with the odds ratios (OR) decreasing progressively to 0.67 (95% confidence interval [CI] 0.57-0.79, P<0.0001) in the highest BMI quintiles (BMI >or=25.66) group compared with the lowest BMI quintiles (BMI <20.97) group. In linear regression models, atrophic gastritis predicted BMI (regression coefficient -0.326, 95% CI -0.469, -0.184, P<0.0001), whereas H. pylori antibody was not a predictor (regression coefficient 0.072, 95% CI -0.053, 0.198, P=0.3).
  
  
  CONCLUSIONS
  A small, inverse association between BMI and atrophic gastritis was found in the general population. In contrast, no association was observed between H. pylori seropositivity and BMI.
authors.affiliation: Medical Sciences, Gardiner Institute, Western Infirmary, University of Glasgow, Glasgow G11 6NT, UK.
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Watabe
authors.forename: Toru
authors.initials: T
authors.lastname: Mitsushima
authors.forename: Mohammad H
authors.initials: MH
authors.lastname: Derakhshan
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yamaji
authors.forename: Makoto
authors.initials: M
authors.lastname: Okamoto
authors.forename: Takao
authors.initials: T
authors.lastname: Kawabe
authors.forename: Masao
authors.initials: M
authors.lastname: Omata
authors.forename: Kenneth E L
authors.initials: KE
authors.lastname: McColl
mesh_terms: D000328:Adult; D000367:Age Factors; D000907:Antibodies, Bacterial / Q000097:blood; D044466:Asian People / Q000706:statistics & numerical data; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D005757:Gastritis, Atrophic / Q000208:ethnology / Q000209:etiology / Q000503:physiopathology*; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000208:ethnology / Q000209:etiology / Q000382:microbiology / Q000503:physiopathology*; D016480:Helicobacter pylori / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D016017:Odds Ratio; D020116:Pepsinogen A / Q000097:blood; D020115:Pepsinogen C / Q000097:blood; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D000907:Antibodies, Bacterial; D020115:Pepsinogen C; D020116:Pepsinogen A
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