Myelodysplasia and Good syndrome. A case report.
Good syndrome (GS) is a rare adult-onset immunodeficiency disease characterised by hypogammaglobulinaemia and thymoma. Here we describe a 72-year-old male patient who was diagnosed with GS when he was 62, after a two-year history of recurrent respiratory infections. A chest CT scan showed a mediastinal mass which was surgically removed; its histology revealed a thymoma. The patient was hypogammaglobulinaemic and his clinical condition dramatically improved after starting an appropriate dosage of IVIG. Two years ago he developed a normochromic normocytic anaemia requiring several transfusions. A bone marrow biopsy revealed a myelodysplastic syndrome. The patient started cyclosporine and the anaemia gradually improved, achieving transfusion independence.
Di Renzo
M
M
U.O. di Medicina III, Policlinico Le Scotte, Viale Bracci 16, Siena, Italy. cd28apo@hotmail.com
Pasqui
A L
AL
Voltolini
L
L
Gotti
G
G
Pompella
G
G
Auteri
A
A
D000368:Aged; D016572:Cyclosporine / Q000627:therapeutic use; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications / Q000175:diagnosis*; D008297:Male; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy
D016572:Cyclosporine
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