Securing mucosal borders--migrant monocytes to the rescue.
Gr1(+) "inflammatory" monocytes are emerging as key players in the innate immune response to infection and vaccination. In a recent issue of Immunity, Dunay et al. (2008) report a surprisingly crucial role for inflammatory monocytes in mucosal resistance to the parasitic agent Toxoplasma gondii.
Yap
George S
GS
Center for Immunity and Inflammation, Department of Medicine, UMDNJ-New Jersey Medical School, Newark, NJ 07101, USA. yapgs@umdnj.edu
Iwasaki
Akiko
A
D000818:Animals; D007113:Immunity, Innate; D051379:Mice; D009000:Monocytes / Q000276:immunology*; D009092:Mucous Membrane / Q000276:immunology / Q000469:parasitology*; D014122:Toxoplasma / Q000502:physiology*; D014124:Toxoplasmosis, Animal / Q000276:immunology* / Q000469:parasitology