The formation of nicotinamide by administration of di(2-ethylhexyl)phthalate does not cause growth retardation in young rats in contrast with excess exogenous administration of nicotinamide.
We investigated the relationship between protein and tryptophan intake and the adverse-effect-level of di(2-ethylhexyl)phthalate (DEHP). Growth retardation of young rats due to DEHP was strengthened by increasing protein level. The addition of tryptophan to the diet caused extreme increases in the nicotinamide formation, but no growth retardation was observed.
Fukuwatari
Tsutomu
T
Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, Shiga, USA. fukkie@shc.usp.ac.jp
Shibata
Katsumi
K
D000818:Animals; D004051:Diethylhexyl Phthalate / Q000378:metabolism / Q000494:pharmacology*; D006128:Growth / Q000187:drug effects*; D008297:Male; D009536:Niacinamide / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D009536:Niacinamide; D004051:Diethylhexyl Phthalate