title: Novel oxidized derivatives of antifungal pyrrolnitrin from the bacterium Burkholderia cepacia K87.
abstract: The screening of antifungal active compounds from the fermentation extracts of soil-borne bacterium Burkholderia cepacia K87 afforded pyrrolnitrin (1) and two new pyrrolnitrin analogs, 3-chloro-4-(3-chloro-2-nitrophenyl)-5-methoxy-3-pyrrolin-2-one (2) and 4-chloro-3-(3-chloro-2-nitrophenyl)-5-methoxy-3-pyrrolin-2-one (3). Pyrrolnitrin showed strong antifungal activity against Rhizoctonia solani but the analogs (2 and 3) were found to be marginally active. The isolates, 2 and 3, are believed to be biodegraded derivatives of pyrrolnitrin.
authors.affiliation: Department of Chemistry, Kongju National University, Kongju, Korea.
authors.forename: Zakir
authors.initials: Z
authors.lastname: Sultan
authors.forename: Kyungseok
authors.initials: K
authors.lastname: Park
authors.forename: Sang Yeob
authors.initials: SY
authors.lastname: Lee
authors.forename: Jung Kon
authors.initials: JK
authors.lastname: Park
authors.forename: Titto
authors.initials: T
authors.lastname: Varughese
authors.forename: Surk-Sik
authors.initials: SS
authors.lastname: Moon
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D016956:Burkholderia cepacia / Q000737:chemistry* / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011764:Pyrrolnitrin / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D012232:Rhizoctonia / Q000187:drug effects; D012988:Soil Microbiology
chemical_list: D000935:Antifungal Agents; D011764:Pyrrolnitrin