title: Tetracyclic terpenoids from Dasyscyphus niveus, dasyscyphins D and E.
abstract: Cultures of the ascomycete Dasyscyphus niveus have yielded two new tetracyclic dasyscyphin-type terpenoids (1 and 2), and their structures were elucidated by NMR spectroscopy and X-ray crystallography. The absolute configuration of dasyscyphin D (1) was determined by synthesis and NMR spectroscopy of diastereomeric MTPA esters. Both compounds inhibited the germination of conidia of Magnaporthe grisea at 25 microg/mL.
authors.affiliation: Institut für Organische Chemie, Universität Hamburg, Martin-Luther-King-Platz 6, D-20146 Hamburg, Germany.
authors.forename: Johannes C
authors.initials: JC
authors.lastname: Liermann
authors.forename: Heinz
authors.initials: H
authors.lastname: Kolshorn
authors.forename: Heidrun
authors.initials: H
authors.lastname: Anke
authors.forename: Eckhard
authors.initials: E
authors.lastname: Thines
authors.forename: Till
authors.initials: T
authors.lastname: Opatz
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D029964:Fagus / Q000382:microbiology; D005260:Female; D005858:Germany; D006801:Humans; D020082:Magnaporthe / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000935:Antifungal Agents; D004224:Diterpenes; C532734:dasyscyphin D; C532735:dasyscyphin E