Association of CT60 polymorphism of the CTLA4 gene with Graves' disease in Taiwanese children.
BACKGROUND
The CTLA4 gene is involved in the activity of T cells.


OBJECTIVE
To determine the association between Graves' disease (GD) susceptibility and CT60 polymorphism of the CTLA4 gene.


METHODS
189 children with GD and 620 healthy controls.


METHODS
We determined the genotype with restriction fragment length polymorphism and compared results.


RESULTS
Genotype G/G was significantly associated with GD (odds ratio [OR] = 1.71, 95% confidence interval [CI] 1.20-2.44, Pc = 0.006); however, allele A could reverse its effect. Allele G was significantly more frequent (OR = 1.61, 95% CI 1.18-2.19, Pc = 0.0049) but allele A (OR = 0.62, 95% CI 0.46-0.85, Pc = 0.0049) and phenotype A (OR = 0.58, 95% CI 0.41-0.83, Pc = 0.006) were less frequent in patients with GD than in controls.


CONCLUSIONS
The CT60 SNP was associated with susceptibility to GD. The G allele increased the risk of GD.
Tsai
Suei-Tsau
ST
Department of Pediatrics, Taiwan Adventist Hospital, Taipei, Taiwan.
Huang
Chi-Yu
CY
Lo
Fu-Sung
FS
Chang
Ya-Ting
YT
Tanizawa
Takakuni
T
Chen
Chi-Kai
CK
Wang
Zen-Chong
ZC
Liu
Hsin-Fu
HF
Chu
Chen-Chung
CC
Lin
Marie
M
Lin
Chao-Hsu
CH
Li
Hsin-Jung
HJ
Lee
Yann-Jinn
YJ
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000483:Alleles; D015703:Antigens, CD / Q000235:genetics*; D060908:CTLA-4 Antigen; D002648:Child; D002675:Child, Preschool; D004247:DNA / Q000096:biosynthesis / Q000235:genetics; D005260:Female; D005838:Genotype; D006111:Graves Disease / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D007223:Infant; D008297:Male; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013601:T-Lymphocytes / Q000378:metabolism; D013624:Taiwan / Q000453:epidemiology; D013960:Thyroid Function Tests; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood
D015703:Antigens, CD; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; D013972:Thyrotropin; D004247:DNA; D013974:Thyroxine