title: The coming of age of artificial intelligence in medicine.
abstract: This paper is based on a panel discussion held at the Artificial Intelligence in Medicine Europe (AIME) conference in Amsterdam, The Netherlands, in July 2007. It had been more than 15 years since Edward Shortliffe gave a talk at AIME in which he characterized artificial intelligence (AI) in medicine as being in its "adolescence" (Shortliffe EH. The adolescence of AI in medicine: will the field come of age in the '90s? Artificial Intelligence in Medicine 1993;5:93-106). In this article, the discussants reflect on medical AI research during the subsequent years and characterize the maturity and influence that has been achieved to date. Participants focus on their personal areas of expertise, ranging from clinical decision-making, reasoning under uncertainty, and knowledge representation to systems integration, translational bioinformatics, and cognitive issues in both the modeling of expertise and the creation of acceptable systems.
authors.affiliation: Department of Biomedical Informatics, Arizona State University, ABC1, 425 North Fifth Street, Phoenix, AZ 85004, USA. vimla@asu.edu
authors.forename: Vimla L
authors.initials: VL
authors.lastname: Patel
authors.forename: Edward H
authors.initials: EH
authors.lastname: Shortliffe
authors.forename: Mario
authors.initials: M
authors.lastname: Stefanelli
authors.forename: Peter
authors.initials: P
authors.lastname: Szolovits
authors.forename: Michael R
authors.initials: MR
authors.lastname: Berthold
authors.forename: Riccardo
authors.initials: R
authors.lastname: Bellazzi
authors.forename: Ameen
authors.initials: A
authors.lastname: Abu-Hanna
mesh_terms: D001185:Artificial Intelligence; D035843:Biomedical Research / Q000639:trends*; D006801:Humans; D008491:Medical Informatics Applications
references.citation: Arch Intern Med. 1994 Jul 11;154(13):1511-7
references.pmid: 8018007
references.citation: Int J Med Inform. 2008 Feb;77(2):81-97
references.pmid: 17188928
references.citation: J Biomed Inform. 2007 Dec;40(6):605-8
references.pmid: 17959422
references.citation: Methods Inf Med. 1990 Jan;29(1):1-2
references.pmid: 2407929
references.citation: Stud Health Technol Inform. 2007;129(Pt 2):834-9
references.pmid: 17911833
references.citation: J Am Med Inform Assoc. 1996 Nov-Dec;3(6):363-6
references.pmid: 8930853
references.citation: Artif Intell Med. 1993 Apr;5(2):93-106
references.pmid: 8358494
references.citation: Artif Intell Med. 1998 Sep-Oct;14(1-2):157-81
references.pmid: 9779888
references.citation: Nat Biotechnol. 2006 Jan;24(1):55-62
references.pmid: 16404398
references.citation: Artif Intell Med. 1998 Sep-Oct;14(1-2):119-37
references.pmid: 9779886
references.citation: N Engl J Med. 1982 Aug 19;307(8):468-76
references.pmid: 7048091
references.citation: Amyloid. 2005 Jun;12(2):120-6
references.pmid: 16011989
references.citation: Comput Methods Programs Biomed. 2007 Dec;88(3):191-6
references.pmid: 18022275
references.citation: Artif Intell Med. 2001 Aug;23(1):25-47
references.pmid: 11470215
references.citation: Bioinformatics. 2006 Jul 15;22(14):e464-71
references.pmid: 16873508
references.citation: Int J Med Inform. 2001 Sep;63(1-2):5-18
references.pmid: 11518661
references.citation: J Am Med Inform Assoc. 2005 Jul-Aug;12(4):377-82
references.pmid: 15802485
references.citation: J Biomed Inform. 2007 Oct;40(5):486-99
references.pmid: 17258510
references.citation: Nature. 2004 Jan 15;427(6971):247-52
references.pmid: 14724639
references.citation: J Biomed Inform. 2002 Apr;35(2):123-39
references.pmid: 12474426
references.citation: Artif Intell Med. 2006 Jul;37(3):163-5
references.pmid: 16690309
references.citation: AMIA Annu Symp Proc. 2003;:953
references.pmid: 14728458
references.citation: J Biomed Inform. 2008 Jun;41(3):413-31
references.pmid: 18343731
references.citation: Artif Intell Med. 2000 Aug;20(1):5-22
references.pmid: 11185420