title: Focal nodular hyperplasia-like lesion of the liver in a child previously treated for nephroblastoma.
abstract: Described herein is the case of an 8-year-old boy who developed a hepatic nodular lesion after having received anti-neoplastic therapy for nephroblastoma. Histological examination of the excised specimen indicated a disordered arrangement of hepatic components with hemangioma-like features. This case was diagnosed as a variant of focal nodular hyperplasia. It is speculated that this hepatic lesion is a late complication of treatment for nephroblastoma and might develop from congenital malformative area of the liver.
authors.affiliation: Department of Pathology, Miyagi Children's Hospital, Sendai, Japan. jtakeyama@yahoo.co.jp
authors.forename: Junji
authors.initials: J
authors.lastname: Takeyama
authors.forename: Ryo
authors.initials: R
authors.lastname: Ando
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Sato
authors.forename: Masaki
authors.initials: M
authors.lastname: Nio
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Shimanuki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sato
authors.forename: Masue
authors.initials: M
authors.lastname: Imaizumi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury; D002648:Child; D003131:Combined Modality Therapy; D003609:Dactinomycin / Q000008:administration & dosage; D020518:Focal Nodular Hyperplasia / Q000139:chemically induced*; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D009392:Nephrectomy; D014750:Vincristine / Q000008:administration & dosage; D009396:Wilms Tumor / Q000188:drug therapy*
chemical_list: D003609:Dactinomycin; D014750:Vincristine