title: Subcutaneous sarcoidosis.
abstract: Subcutaneous sarcoidosis has been reported to occur in 1.4% to 6% of patients with systemic sarcoidosis. Most reported cases are in women, most often in their fifth and sixth decades, and appear as multiple, asymptomatic, hardly indurated subcutaneous nodules without changes in the overlying epidermis. The lesions are characteristically located in the upper extremities, mainly in the forearms, and usually are bilateral and asymmetric. In most cases the lesions appear at the beginning of systemic sarcoidosis and are not associated with chronic fibrotic disease. Histopathologically, sarcoidosis is characterized by noncaseating naked granulomas involving fat lobules, with minimal to no septal involvement.
authors.affiliation: Department of Dermatology, Hospital de Bellvitge, IDIBELL, University of Barcelona, C/Feixa Llarga s/n, Hospitalet de Llobregat, 08907-Barcelona, Spain. jmarcoval@csub.scs.es
authors.forename: Joaquim
authors.initials: J
authors.lastname: Marcoval
authors.forename: Abelardo
authors.initials: A
authors.lastname: Moreno
authors.forename: Juan
authors.initials: J
authors.lastname: Mañá
authors.forename: Jordi
authors.initials: J
authors.lastname: Peyri
mesh_terms: D003937:Diagnosis, Differential; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D012507:Sarcoidosis / Q000188:drug therapy / Q000473:pathology*; D012871:Skin Diseases / Q000188:drug therapy / Q000473:pathology*; D040521:Subcutaneous Tissue / Q000473:pathology*
chemical_list: D005938:Glucocorticoids