title: The molecular regulation of Chinook salmon gonadotropin beta-subunit gene transcription.
abstract: Expression of the gonadotropin beta-subunit genes is tightly regulated both cell-specifically and by the regulatory hormones to achieve the appropriate gonadotropic hormone levels required for reproductive development and function. Although the cDNA sequences of these genes are highly conserved across species, their promoter sequences are not and few functional studies have been carried out to understand the molecular mechanisms through which their expression is regulated. We and others have carried out several studies on the LHbeta gene promoter of Chinook salmon (Oncorhynchus tschawytscha), and also isolated the FSHbeta gene from the same species. We present here a review of these studies and also novel data pertaining to both genes, in an attempt to collate the current understanding of the molecular regulation of the gonadotropin beta-subunit genes in these fish.
authors.affiliation: Department of Biological Sciences, National University of Singapore, Singapore.
authors.forename: Sihui
authors.initials: S
authors.lastname: Wang
authors.forename: Yunhua
authors.initials: Y
authors.lastname: Zhu
authors.forename: Philippa
authors.initials: P
authors.lastname: Melamed
mesh_terms: D028341:Activins / Q000502:physiology; D000818:Animals; D001483:Base Sequence; D019556:COS Cells; D002460:Cell Line; D002522:Chlorocebus aethiops; D004268:DNA-Binding Proteins / Q000502:physiology; D037201:Follicle Stimulating Hormone, beta Subunit / Q000235:genetics*; D005786:Gene Expression Regulation; D006062:Gonadotropins / Q000235:genetics*; D006801:Humans; D037101:Luteinizing Hormone, beta Subunit / Q000235:genetics*; D008969:Molecular Sequence Data; D057105:Nuclear Receptor Subfamily 4, Group A, Member 1; D011401:Promoter Regions, Genetic / Q000502:physiology*; D011987:Receptors, Steroid / Q000502:physiology; D012474:Salmon / Q000235:genetics*; D016415:Sequence Alignment; D051785:Smad Proteins / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology; D015854:Up-Regulation
chemical_list: D004268:DNA-Binding Proteins; D037201:Follicle Stimulating Hormone, beta Subunit; D006062:Gonadotropins; D037101:Luteinizing Hormone, beta Subunit; C539821:NR4A1 protein, human; D057105:Nuclear Receptor Subfamily 4, Group A, Member 1; D011987:Receptors, Steroid; D051785:Smad Proteins; D014157:Transcription Factors; C016844:salmon gonadotropin; D028341:Activins