Single nucleotide polymorphisms associated with coronary heart disease predict incident ischemic stroke in the atherosclerosis risk in communities study.
Ischemic stroke and coronary heart disease (CHD) may share genetic factors contributing to a common etiology. This study investigates whether 51 single nucleotide polymorphisms (SNPs) associated with CHD in multiple antecedent studies are associated with incident ischemic stroke in the Atherosclerosis Risk in Communities (ARIC) study. From the multiethnic ARIC cohort of 14,215 individuals, 495 validated ischemic strokes were identified. Cox proportional hazards models, adjusted for age and gender, identified three SNPs in Whites and two SNPs in Blacks associated with incident stroke (p <or= 0.05). The rs11628722 polymorphism in SERPINA9 was associated with incident stroke in Whites and Blacks, even after taking into account traditional risk factors. The idea that ischemic stroke and CHD may share some common genetic factors, such as variation in SERPINA9, should be investigated in other studies.
Morrison
Alanna C
AC
Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Alanna.C.Morrison@uth.tmc.edu
Bare
Lance A
LA
Luke
May M
MM
Pankow
James S
JS
Mosley
Thomas H
TH
Devlin
James J
JJ
Willerson
James T
JT
Boerwinkle
Eric
E
D044383:Black People / Q000235:genetics / Q000706:statistics & numerical data; D002545:Brain Ischemia / Q000453:epidemiology / Q000235:genetics; D003327:Coronary Disease / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D015994:Incidence; D002537:Intracranial Arteriosclerosis / Q000453:epidemiology / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology / Q000235:genetics; D009363:Neoplasm Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D012307:Risk Factors; D015843:Serpins / Q000235:genetics*; D020521:Stroke / Q000453:epidemiology* / Q000235:genetics*; D044465:White People / Q000235:genetics / Q000706:statistics & numerical data
D009363:Neoplasm Proteins; C476825:SERPINA9 protein, human; D015843:Serpins
Circulation. 1998 May 12;97(18):1837-47
9603539
Am J Epidemiol. 1989 Apr;129(4):687-702
2646917
Stroke. 1999 Apr;30(4):736-43
10187871
N Engl J Med. 2000 Oct 19;343(16):1148-55
11036120
Stroke. 1991 Mar;22(3):312-8
2003301
J Thromb Thrombolysis. 2004 Feb;17(1):51-61
15277788
Neurochem Res. 2006 Aug;31(8):1035-44
16933151
Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2763-8
17008591
Nat Rev Genet. 2006 Oct;7(10):812-20
16983377
Am J Epidemiol. 2007 Jul 1;166(1):28-35
17443022
Genet Med. 2007 Oct;9(10):682-9
18073581
Genome Biol. 2006;7(5):216
16737556
Diabetes Care. 1999 Jul;22(7):1077-83
10388971
Circulation. 2007 Feb 6;115(5):e69-171
17194875
J Am Coll Cardiol. 2008 Jan 29;51(4):435-43
18222353
N Engl J Med. 1996 Oct 3;335(14):1001-9
8801446
Crit Rev Biomed Eng. 1999;27(1-2):75-148
10638850
Cytometry. 2000 Feb 1;39(2):131-40
10679731