Beta2-microglobulin abnormalities in antipsychotic-naïve schizophrenia: evidence for immune pathogenesis.
Studies examining immune dysfunction in schizophrenia have reported decreased type-1 T-helper cell specific immunity (Th1) and increased type-2 T-helper cell specific immunity (Th2) and related abnormalities in inflammatory system. Beta2-Microglobulin (beta2M) influences the development of dendritic cells, which play a significant role in regulating the differentiation of naive CD4+ T cells into Th1 or Th2 lineages. The present study examined serum beta2M in antipsychotic-naïve schizophrenia patients (n=43) in comparison with age, sex, handedness and socioeconomic status matched healthy controls (n=43). Serum beta2M was significantly higher in schizophrenia patients (1692.6+/-354.4 ng/mL) than healthy controls (1409.6+/-246.9 ng/mL) (t=4.3; p<0.0001). There was a significant positive correlation between beta2M level and total psychopathology score (r=0.32; p=0.035). These novel observations suggest that beta2M abnormalities might have a potential association with the pathogenesis of schizophrenia.
Chittiprol
Seetharamaiah
S
Department of Neurochemistry, National Institute of Mental Health and Neurosciences, Bangalore 560029, India.
Venkatasubramanian
Ganesan
G
Neelakantachar
Narendran
N
Allha
Naveen
N
Shetty
Kurudunje Taranath
KT
Gangadhar
Bangalore N
BN
D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008163:Luminescent Measurements; D008297:Male; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000188:drug therapy / Q000276:immunology*; D012720:Severity of Illness Index; D001613:beta 2-Microglobulin / Q000097:blood* / Q000276:immunology
D014150:Antipsychotic Agents; D001613:beta 2-Microglobulin