Synthesis of novel bicyclic nucleosides with 3,6-anhydro sugar moiety.
Based on the biological importance of conformationally restricted nucleoside analogues, we have efficiently synthesized 3,6-anhydro sugar moiety with 3-C-hydroxymethyl substituent from 1,2;5,6-di-O-isopropylidene-D-glucose and condensed 15 with silylated nucleobases to afford the bicyclic nucleoside with 3,6-anhydro skeleton as potential antiviral agent.
Kim
Myong Jung
MJ
Foundation for Applied Molecular Evolution, Gainesville, Florida 32601, USA. mkim@ffame.org
D000998:Antiviral Agents / Q000138:chemical synthesis*; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis*; D005947:Glucose / Q000031:analogs & derivatives* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis*
D000998:Antiviral Agents; D001643:Bridged Bicyclo Compounds; D009705:Nucleosides; C080557:3,6-anhydroglucose; D005947:Glucose