Effect of Lactobacillus acidophilus strain L-55 on the development of atopic dermatitis-like skin lesions in NC/Nga mice.
In this study, we examined whether Lactobacillus acidophilus strain L-55 (strain L-55) suppresses the development of atopic dermatitis (AD)-like skin lesions induced by repeated application of 2,4,6-trinitrochlorobenzene (TNCB) in sensitized NC/Nga mice. The effect of strain L-55 was assessed by measuring clinical symptoms, ear swelling, scratching behavior and serum levels of total IgE. Strain L-55 was administered orally once a day: Strain L-55 at doses of 1 and 10 mg cells/mouse inhibited the development of AD-like skin lesions in dermatitis scores for the back. The increase of dermatitis score and ear swelling was also inhibited by strain L-55. In addition, strain L-55 also caused an inhibition of histological changes induced by repeated application of TNCB. Scratching behavior observed in the back and ear was inhibited by strain L-55. Furthermore elevated serum IgE levels observed by TNCB were also decreased by strain L-55. These results indicate that the inhibition of strain L-55 on AD-like lesions induced by repeated application of TNCB in sensitized NC/Nga mice occurred via a decrease in the serum total IgE level.
Sunada
Yosuke
Y
Fundamental Laboratory, Ohayo Dairy Products Co., Ltd., Okayama 701-1221, Japan.
Nakamura
Syoji
S
Kamei
Chiaki
C
D000818:Animals; D003876:Dermatitis, Atopic / Q000139:chemically induced / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D007073:Immunoglobulin E / Q000097:blood* / Q000187:drug effects; D007779:Lactobacillus acidophilus / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D010853:Picryl Chloride / Q000494:pharmacology; D012867:Skin / Q000187:drug effects / Q000276:immunology* / Q000382:microbiology / Q000473:pathology
D007073:Immunoglobulin E; D010853:Picryl Chloride