Piceatannol, a stilbene present in grapes, attenuates dextran sulfate sodium-induced colitis.
Piceatannol (3,5,3',4'-tetrahydroxy-trans-stilbene; PIC) is a polyphenol found in grapes. It is known as a protein kinase inhibitor that modifies multiple cellular targets, exerting immunosuppressive and antitumorigenic activities in several cell lines. The purpose of the present work was to evaluate the anti-inflammatory effect of PIC on dextran sulfate sodium (DSS)-induced colitis. Experimental colitis was induced in BALB/c mice by dissolving 5% DSS in their drinking water for 7 days. PIC (1, 2.5, 5, or 10 mg/kg body weight) was administrated daily per oral route for 7 days. A significant blunting of weight loss and clinical signs was observed in DSS-exposed, PIC-treated mice when compared to vehicle-treated mice. This was associated with a remarkable amelioration of the disruption of the colonic architecture, a significant reduction in colonic myeloperoxidase (MPO) activity, and a decrease in production of inflammatory mediators such as nitric oxide (NO), prostaglandin (PG) E2, and pro-inflammatory cytokines. The present data indicate that further evaluation of the potential of PIC as an agent for the prevention and/or treatment of inflammatory bowel diseases in human clinical studies is warranted.
Kim
Yoon Hee
YH
Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University, Chuncheon 200-702, Republic of Korea.
Kwon
Hyuck-Se
HS
Kim
Dae Hwan
DH
Cho
Han Jin
HJ
Lee
Hyun Suck
HS
Jun
Jong-Gab
JG
Park
Jung Han Yoon
JH
Kim
Jin-Kyung
JK
D000818:Animals; D003092:Colitis / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D003106:Colon / Q000276:immunology; D016264:Dextran Sulfate / Q000633:toxicity; D005260:Female; D007150:Immunohistochemistry; D018836:Inflammation Mediators / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D016328:NF-kappa B / Q000032:analysis; D009195:Peroxidase / Q000378:metabolism; D050796:STAT3 Transcription Factor / Q000032:analysis; D013267:Stilbenes / Q000627:therapeutic use*; D027843:Vitis / Q000737:chemistry*
D018836:Inflammation Mediators; D016328:NF-kappa B; D050796:STAT3 Transcription Factor; C494087:Stat3 protein, mouse; D013267:Stilbenes; C041525:3,3',4,5'-tetrahydroxystilbene; D016264:Dextran Sulfate; D009195:Peroxidase