The role of dopamine and serotonin in suicidal behaviour and aggression.
Serotonin and dopamine are two monoamines which are known to interact with each other. Their role for suicidal behaviour, aggression and mood are reviewed in this chapter. We found a substantial amount of evidence for the relevance of a serotonin and dopamine model of aggression, and for aggression as a major risk factor for suicide. Evidence was found that serotonin and dopamine also may be involved in depressed mood, and possibly the individual's ability to cope with imminent suicidality.
Ryding
Erik
E
Department of Clinical Neurophysiology, Karolinska Hospital, Huddinge, SE 141 52 Stockholm, Sweden. erik.ryding@karolinska.se
Lindström
Mats
M
Träskman-Bendz
Lil
L
D000374:Aggression; D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism; D003863:Depression / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D012307:Risk Factors; D012701:Serotonin / Q000378:metabolism*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D013405:Suicide
D004298:Dopamine; D012701:Serotonin; D050486:Serotonin Plasma Membrane Transport Proteins; D017367:Selective Serotonin Reuptake Inhibitors