title: Uniformity in clinical and HLA-DR status regardless of age and gender within fulminant type 1 diabetes.
abstract: To clarify the detailed clinical features and HLA subtype in the patients with fulminant type 1 diabetes, we investigated consecutive 250 case records registered to the committee of the Japan Diabetes Society between 2000/7/15 and 2006/6/30. After the classification with age at onset or gender, clinical data and HLA DR were evaluated. As a result, the prevalence of male patients, BMI, HbA(1c) and ALT levels at the onset increased significantly according to the elder quartile, but no other data showed any significant difference. Only age at onset and blood glucose level were significantly higher in male patients than in female patients without pregnancy by multivariate analysis. The distribution of HLA DR was not different in any subtype by gender or age at onset. Our present study revealed common feature in clinical and HLA-DR status regardless of age and gender within fulminant type 1 diabetes except pregnant women.
authors.affiliation: First Department of Internal Medicine, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki 569-8686, Japan.
authors.forename: Akihisa
authors.initials: A
authors.lastname: Imagawa
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Hanafusa
authors.forename: Hiromi
authors.initials: H
authors.lastname: Iwahashi
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Uchigata
authors.forename: Azuma
authors.initials: A
authors.lastname: Kanatsuka
authors.forename: Eiji
authors.initials: E
authors.lastname: Kawasaki
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Akira
authors.initials: A
authors.lastname: Shimada
authors.forename: Ikki
authors.initials: I
authors.lastname: Shimizu
authors.forename: Taro
authors.initials: T
authors.lastname: Maruyama
authors.forename: Hideichi
authors.initials: H
authors.lastname: Makino
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology* / Q000378:metabolism; D005260:Female; D006684:HLA-DR Antigens / Q000276:immunology*; D006801:Humans; D007223:Infant; D007564:Japan; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D012737:Sex Factors; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D006684:HLA-DR Antigens