title: Multiple capillary hemangiomas: a distinctive lesion of multicentric Castleman's disease and POEMS syndrome.
abstract: A diagnosed case of Castleman's disease, proven by biopsy from enlarged inguinal lymph nodes, presented with multiple, asymptomatic, erythematous papules and nodules prevalent since nine years over the trunk and extremities. The lesions had been gradually increasing in number and size. The patient had had plasmacytoma of the lower thoracic vertebra 12 years ago, for which he was adequately treated with chemotherapy and local radiotherapy. Dermatological examination revealed erythematous papules and nodules on the face, trunk, and extremities that were diagnostic of capillary hemangiomas. Histopathology of the erythematous, soft papule was suggestive of capillary hemangioma. Contrast-enhanced computerized tomography of the abdomen and pelvis showed multiple retroperitoneal nodes suggestive of Castleman's disease along with multiple osteolytic lesions in the pelvic girdle and vertebrae. The patient was treated with injection rituximab and is currently under follow-up. We report this case to highlight a rare association between Castleman's disease and POEMS syndrome.
authors.affiliation: Department of Dermatology, Seth GSMC and KEM Hospital, Parel, Mumbai-12, India. vidyakharkar@gmail.com
authors.forename: Rachita
authors.initials: R
authors.lastname: Misri
authors.forename: Vidya
authors.initials: V
authors.lastname: Kharkar
authors.forename: Ameet
authors.initials: A
authors.lastname: Dandale
authors.forename: Vidula
authors.initials: V
authors.lastname: Patel
authors.forename: Sunanda
authors.initials: S
authors.lastname: Mahajan
authors.forename: Uday
authors.initials: U
authors.lastname: Khopkar
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D058846:Antibodies, Monoclonal, Murine-Derived; D005871:Castleman Disease / Q000150:complications* / Q000188:drug therapy; D018324:Hemangioma, Capillary / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000209:etiology* / Q000473:pathology; D016878:POEMS Syndrome / Q000150:complications*; D000069283:Rituximab; D012878:Skin Neoplasms / Q000209:etiology* / Q000473:pathology / Q000601:surgery
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D007155:Immunologic Factors; D000069283:Rituximab