[Impact of tumorcytogenetics in tumor diagnostics].
Most tumors are caused by acquired somatic mutations. For half a century now chromosomal anomalies in hematological neoplasia and to a much less extent in solid tumors are investigated by conventional cytogenetics. During all this time the significance of genetic factors for tumor classification increased continuously. Especially for haematological neoplasia, besides <<classical>> cytogenetic parameters, molecular genetic factors are becoming more and more important. For technical and analytical reasons conventional cytogenetics does not play a role in routine diagnostics of solid tumors. However, well known chromosome aberrations are increasingly investigated by fluorescence-in-situ Hybridization (FISH) and by molecular genetic methods. In the future microarray-based methods will become more and more important in the diagnostics of various tumors.
Wenzel
Friedel
F
Abteilung Medizinische Genetik, Universitäts-Kinderspital beider Basel, Basel.
Röthlisberger
Benno
B
D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis / Q000379:methods*; D004252:DNA Mutational Analysis / Q000379:methods*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods*; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics*