title: Dynamic kinetic resolution of racemic beta-haloalcohols: direct access to enantioenriched epoxides.
abstract: The direct chemo-enzymatic DKR of racemic beta-haloalcohols is reported, yielding the corresponding optically active epoxides in a single step. The mutant haloalcohol dehalogenase HheC Cys153Ser Trp249Phe is used for the asymmetric ring closure, whereas racemization of the remaining enantiomer of the haloalcohol is achieved using the new iridacycle 3, one of the most effective racemization catalysts to date for beta-haloalcohols.
authors.affiliation: Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Haak
authors.forename: Florian
authors.initials: F
authors.lastname: Berthiol
authors.forename: Thomas
authors.initials: T
authors.lastname: Jerphagnon
authors.forename: Arnaud J A
authors.initials: AJ
authors.lastname: Gayet
authors.forename: Chiara
authors.initials: C
authors.lastname: Tarabiono
authors.forename: Christiaan P
authors.initials: CP
authors.lastname: Postema
authors.forename: Vincent
authors.initials: V
authors.lastname: Ritleng
authors.forename: Michel
authors.initials: M
authors.lastname: Pfeffer
authors.forename: Dick B
authors.initials: DB
authors.lastname: Janssen
authors.forename: Adriaan J
authors.initials: AJ
authors.lastname: Minnaard
authors.forename: Ben L
authors.initials: BL
authors.lastname: Feringa
authors.forename: Johannes G
authors.initials: JG
authors.lastname: de Vries
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D004852:Epoxy Compounds / Q000737:chemistry*; D006219:Halogens / Q000737:chemistry*; D007700:Kinetics; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D004852:Epoxy Compounds; D006219:Halogens