Transforming growth factor beta (TGFbeta1, TGFbeta2 and TGFbeta3) null-mutant phenotypes in embryonic gonadal development.
The role transforming growth factor beta (TGFb) isoforms TGFb1, TGFb2 and TGFb3 have in the regulation of embryonic gonadal development was investigated with the use of null-mutant (i.e. knockout) mice for each of the TGFb isoforms. Late embryonic gonadal development was investigated because homozygote TGFb null-mutant mice generally die around birth, with some embryonic loss as well. In the testis, the TGFb1 null-mutant mice had a decrease in the number of germ cells at birth, postnatal day 0 (P0). In the testis, the TGFb2 null-mutant mice had a decrease in the number of seminiferous cords at embryonic day 15 (E15). In the ovary, the TGFb2 null-mutant mice had an increase in the number of germ cells at P0. TGFb isoforms appear to have a role in gonadal development, but interactions between the isoforms is speculated to compensate in the different TGFb isoform null-mutant mice.
Memon
Mushtaq A
MA
Department of Veterinary Clinical Sciences, Washington State University, Pullman, WA 99164-4234, USA.
Anway
Matthew D
MD
Covert
Trevor R
TR
Uzumcu
Mehmet
M
Skinner
Michael K
MK
D000818:Animals; D034961:Antigens, Nuclear / Q000378:metabolism; D017209:Apoptosis; D002452:Cell Count; D004622:Embryo, Mammalian / Q000166:cytology / Q000378:metabolism; D047108:Embryonic Development / Q000235:genetics*; D005260:Female; D005838:Genotype; D007150:Immunohistochemistry; D020287:In Situ Nick-End Labeling; D008297:Male; D051379:Mice; D009154:Mutation / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D010053:Ovary / Q000166:cytology / Q000196:embryology* / Q000378:metabolism*; D010641:Phenotype; D051381:Rats; D012671:Seminiferous Tubules / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D012744:Sex Ratio; D013737:Testis / Q000166:cytology / Q000196:embryology* / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism; D053773:Transforming Growth Factor beta1 / Q000235:genetics / Q000378:metabolism; D053781:Transforming Growth Factor beta2 / Q000172:deficiency / Q000235:genetics / Q000378:metabolism; D053782:Transforming Growth Factor beta3 / Q000172:deficiency / Q000235:genetics / Q000378:metabolism
D034961:Antigens, Nuclear; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; D053781:Transforming Growth Factor beta2; D053782:Transforming Growth Factor beta3
Important Adv Oncol. 1987;:75-86
2456983
Reproduction. 2003 Aug;126(2):133-48
12887271
Reproduction. 2006 Aug;132(2):233-46
16885532
Bioessays. 2002 Oct;24(10):904-14
12325123
Mol Endocrinol. 1993 Jan;7(1):67-76
8446109
Cardiovasc Res. 2002 Nov;56(2):312-22
12393102
Biol Reprod. 2005 Feb;72(2):492-501
15496517
Reprod Toxicol. 2004 Aug-Sep;18(6):765-74
15279874
J Biol Chem. 2006 Jun 16;281(24):16799-813
16617054
Mol Cell Biol. 1991 Mar;11(3):1185-94
1996085
Cell Tissue Res. 2005 Oct;322(1):107-15
15983782
Mol Cell Endocrinol. 2002 May 31;191(1):35-43
12044917
Mol Reprod Dev. 2006 Oct;73(10):1211-20
16868931
Biol Reprod. 1993 Jan;48(1):40-5
8418916
Anim Reprod Sci. 2003 Oct 15;78(3-4):165-83
12818643
Biol Reprod. 2002 Jun;66(6):1838-45
12021070
Biol Reprod. 2004 Jul;71(1):319-30
15028632
J Endocrinol. 2005 Nov;187(2):205-15
16293768
Biol Reprod. 1999 Jun;60(6):1304-13
10330085
Dev Biol. 1998 Nov 15;203(2):323-33
9808783
Cell Growth Differ. 1991 Feb;2(2):77-83
2069871
Science. 1988 Feb 12;239(4841 Pt 1):783-5
3422517
Cell Tissue Res. 2003 Jul;313(1):1-10
12838410
Nature. 1992 Oct 22;359(6397):693-9
1436033
Nature. 1987 Oct 8-14;329(6139):539-41
2889143
Biol Reprod. 1997 Feb;56(2):357-67
9116134
Mol Endocrinol. 1989 Apr;3(4):625-34
2725526
Apoptosis. 2006 May;11(5):739-48
16532270
Int J Androl. 2003 Jun;26(3):147-60
12755993
Endocrinology. 2007 Aug;148(8):4032-43
17478551
Mol Cell Endocrinol. 1990 Mar 26;70(1):73-80
2160384
Adv Cancer Res. 1988;51:107-45
2906217
Mol Endocrinol. 2002 Dec;16(12):2780-92
12456799
Hum Reprod Update. 2005 Sep-Oct;11(5):461-71
16006439
Eur Cytokine Netw. 1996 Sep;7(3):363-74
8954178
Endocrinology. 2005 Dec;146(12):5135-43
16166221
Mol Endocrinol. 1989 Dec;3(12):1977-86
2628733
Mol Reprod Dev. 1994 Oct;39(2):239-46
7826627
Reproduction. 2006 Aug;132(2):177-8
16885527
Nat Genet. 1995 Dec;11(4):415-21
7493022
J Androl. 2003 Sep-Oct;24(5):736-45
12954667
Biol Reprod. 2000 Mar;62(3):477-90
10684787
Circulation. 2001 Jun 5;103(22):2745-52
11390347
Nat Genet. 1995 Dec;11(4):409-14
7493021
Anat Embryol (Berl). 2002 Dec;206(1-2):73-83
12478370
Histochem Cell Biol. 1998 Dec;110(6):613-8
9860260
Dev Biol. 2005 Apr 15;280(2):321-43
15882576
Endocrinology. 1991 Mar;128(3):1441-9
1847858
Mol Endocrinol. 1989 Dec;3(12):1926-34
2628730
Reprod Fertil Dev. 2005;17(4):435-8
15899155