title: Clinical practice of rTMS reveals a functional dissociation between agency and hallucinations in schizophrenia.
abstract: We report here the case of a hospitalized 11 year-old boy (YP) with a positive diagnosis of 'Childhood Onset Schizophrenia'. YP experienced verbal-auditory hallucinations, a delusion of alien control and hetero-aggressive behaviour. Antipsychotic drugs were unsuccessful and furthermore provoked severe acute dystonia. fMRI-guided rTMS applied over several cortical regions provided the means to reveal for the first time a functional dissociation between auditory-verbal hallucinations and agency. These results demonstrate the efficacy of rTMS for young patients suffering from drug-resistant hallucinations but they furthermore question the physiopathology of the hallucinatory process by suggesting that agency and hallucinations may be sub-served by different neural networks.
authors.affiliation: Université Lille Nord de France, CNRS UMR-8160, CHRU de Lille, 59037 Lille, France. r-jadri@chru-lille.fr
authors.forename: Renaud
authors.initials: R
authors.lastname: Jardri
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Delevoye-Turrell
authors.forename: Bernard
authors.initials: B
authors.lastname: Lucas
authors.forename: Delphine
authors.initials: D
authors.lastname: Pins
authors.forename: Virginie
authors.initials: V
authors.lastname: Bulot
authors.forename: Christine
authors.initials: C
authors.lastname: Delmaire
authors.forename: Pierre
authors.initials: P
authors.lastname: Thomas
authors.forename: Pierre
authors.initials: P
authors.lastname: Delion
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Goeb
mesh_terms: D001931:Brain Mapping; D002648:Child; D004213:Dissociative Disorders / Q000175:diagnosis* / Q000209:etiology; D004558:Electric Stimulation; D006212:Hallucinations / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D012561:Schizophrenia, Childhood / Q000150:complications* / Q000473:pathology; D012565:Schizophrenic Psychology; D050781:Transcranial Magnetic Stimulation / Q000379:methods*
chemical_list: D010100:Oxygen