The small-molecule Bcl-2 inhibitor HA14-1 sensitizes cervical cancer cells, but not normal fibroblasts, to heavy-ion radiation.
This is the first study to demonstrate that the small-molecule Bcl-2 inhibitor HA14-1 renders human cervical cancer cells and their Bcl-2 overexpressing radioresistant counterparts, but not normal fibroblasts, more susceptible to heavy ions. Thus, Bcl-2 may be an attractive target for improving the efficacy of heavy-ion therapy.
Hamada
Nobuyuki
N
Department of Quantum Biology, Gunma University Graduate School of Medicine, Gunma, Japan. hamada@med.gunma-u.ac.jp
Kataoka
Keiko
K
Sora
Sakura
S
Hara
Takamitsu
T
Omura-Minamisawa
Motoko
M
Funayama
Tomoo
T
Sakashita
Tetsuya
T
Nakano
Takashi
T
Kobayashi
Yasuhiko
Y
D001578:Benzopyrans / Q000494:pharmacology*; D016923:Cell Death / Q000528:radiation effects; D002470:Cell Survival / Q000528:radiation effects; D005260:Female; D005347:Fibroblasts / Q000528:radiation effects; D020450:Heavy Ions; D006801:Humans; D009570:Nitriles / Q000494:pharmacology*; D017319:Photosensitizing Agents / Q000494:pharmacology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000037:antagonists & inhibitors*; D011836:Radiation Tolerance; D011839:Radiation, Ionizing; D014407:Tumor Cells, Cultured; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000532:radiotherapy*
D001578:Benzopyrans; D009570:Nitriles; D017319:Photosensitizing Agents; D019253:Proto-Oncogene Proteins c-bcl-2; C456800:ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate