title: Unlocked nucleic acid (UNA) and UNA derivatives: thermal denaturation studies.
abstract: A study on the thermal stability of duplexes formed between unlocked nucleic acid (UNA) modified DNA and RNA oligonucleotides and complementary DNA and RNA is presented. The acyclic UNA monomers are shown to induce a decrease in duplex thermal stability.
authors.affiliation: Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark. tje@ifk.sdu.dk
authors.forename: Troels Bundgaard
authors.initials: TB
authors.lastname: Jensen
authors.forename: Niels
authors.initials: N
authors.lastname: Langkjaer
authors.forename: Jesper
authors.initials: J
authors.lastname: Wengel
mesh_terms: D004247:DNA / Q000737:chemistry; D009691:Nucleic Acid Denaturation; D009841:Oligonucleotides / Q000737:chemistry*; D012313:RNA / Q000737:chemistry; D013696:Temperature; D014498:Uracil / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D009841:Oligonucleotides; C477371:locked nucleic acid; D014498:Uracil; D012313:RNA; D004247:DNA