Common variants of FUT2 are associated with plasma vitamin B12 levels.
We identified a strong association (P = 5.36 x 10(-17)) between rs492602 in FUT2 and plasma vitamin B(12) levels in a genome-wide scan (n = 1,658) and an independent replication sample (n = 1,059) from the Nurses' Health Study. Women homozygous for the rs492602[G] allele had higher B(12) levels. This allele is in strong linkage disequilibrium with the FUT2 nonsecretor variant encoding W143X, suggesting a plausible mechanism for altered B(12) absorption and plasma levels.
Hazra
Aditi
A
Department of Epidemiology, Harvard School of Public Health, Program in Molecular and Genetic Epidemiology, Boston, Massachusetts 02115, USA.
Kraft
Peter
P
Selhub
Jacob
J
Giovannucci
Edward L
EL
Thomas
Gilles
G
Hoover
Robert N
RN
Chanock
Stephen J
SJ
Hunter
David J
DJ
D000328:Adult; D005260:Female; D005647:Fucosyltransferases / Q000235:genetics*; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D015894:Genome, Human; D006720:Homozygote; D006801:Humans; D008875:Middle Aged; D009726:Nurses; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D014805:Vitamin B 12 / Q000097:blood* / Q000235:genetics; D000097631:Galactoside 2-alpha-L-fucosyltransferase
D005647:Fucosyltransferases; D014805:Vitamin B 12; D000097631:Galactoside 2-alpha-L-fucosyltransferase
J Pathol. 2008 Jul;215(3):308-16
18498114
Exp Biol Med (Maywood). 2007 Nov;232(10):1266-74
17959839
Hum Mutat. 2004 Apr;23(4):327-33
15024727
Dig Liver Dis. 2002 Sep;34 Suppl 2:S72-7
12408446
QJM. 2007 Aug;100(8):495-9
17636160
Am J Gastroenterol. 2002 Apr;97(4):861-6
12003420
PLoS Med. 2008 Feb;5(2):e31
18271619
World J Gastroenterol. 2005 Dec 7;11(45):7078-83
16437651
Epidemiology. 2006 Nov;17(6):650-7
17028506
Genetics. 2001 Jun;158(2):747-56
11404338
J Nutr Sci Vitaminol (Tokyo). 2004 Oct;50(5):305-8
15754489
Int J Cancer. 2008 May 1;122(9):2057-61
18092327
Nat Genet. 2007 Jul;39(7):870-4
17529973
J Biol Chem. 1995 Mar 3;270(9):4640-9
7876235
J Lab Clin Med. 1987 Apr;109(4):454-63
3819580