Hyperacute rejection of living related kidney grafts caused by endothelial cell-specific antibodies: case reports.
We describe two cases of hyperacute humoral rejection of living related kidney grafts despite negative pretransplantation T- and B-lymphocyte flow cytometric crossmatches and blood group identity. Retrospectively, antiendothelial IgG antibodies were detected on a panel of umbilical cord cells in the first case, and IgM antibodies against donor endothelial precursor cells were detected using a new endothelial cell crossmatch kit in the second case. Standard crossmatch methods using donor lymphocytes failed to detect these pathogenic antibodies and did not predict the danger of hyperacute rejection.
Grandtnerová
B
B
Transplant Centre, Faculty Hospital, Martin, Slovakia. grandtnerova_barbara@stonline.sk
Mäcková
N
N
Hovoricová
B
B
Jahnová
E
E
D000208:Acute Disease; D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology; D004730:Endothelium, Vascular / Q000276:immunology; D005190:Family; D005260:Female; D006084:Graft Rejection / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood*; D007518:Isoantibodies / Q000097:blood*; D016030:Kidney Transplantation / Q000276:immunology* / Q000473:pathology; D019520:Living Donors; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007518:Isoantibodies