title: Effect of bradyarrhythmia on the plasma levels of N-terminal pro-brain natriuretic peptide.
abstract: To investigate the effect of bradyarrhythmia on the plasma levels of NT-proBNP, patients without defined ventricular diseases were enrolled in this study: group A, 42 patients without arrhythmia; group B, 43 patients with sick sinus syndrome; group C, 22 patients with II degrees atrioventricular block (AVB); group D, 35 patients with III degrees AVB and group E, 35 patients with persistent atrial fibrillation. The plasma levels of NT-proBNP were determined and analyzed. The NT-proBNP levels were lower in group A and B than in group C, D and E (P<0.01), and in group C than in group D and E (P<0.001). Multivariate analysis revealed age and the severity of atrioventricular asynchrony were independent determinants of NT-proBNP levels (P<0.001). These results implicated that the plasma levels of NT-proBNP in patients with bradyarrhythmia increased in proportion to aggravation of atrioventricular asynchrony.
authors.forename: Wenzhi
authors.initials: W
authors.lastname: Pan
authors.forename: Yangang
authors.initials: Y
authors.lastname: Su
authors.forename: Kai
authors.initials: K
authors.lastname: Hu
authors.forename: Xianhong
authors.initials: X
authors.lastname: Shu
authors.forename: Junbo
authors.initials: J
authors.lastname: Ge
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001919:Bradycardia / Q000097:blood* / Q000175:diagnosis* / Q000503:physiopathology; D002304:Cardiac Pacing, Artificial; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011498:Protein Precursors / Q000097:blood
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; D011498:Protein Precursors; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain