title: Progression of atherosclerosis in hemodialysis patients: effect of adiponectin on carotid intima media thickness.
abstract: OBJECTIVE
  We investigated the parameters related to the progression of common carotid artery intima media thickness (IMT) in hemodialysis (HD) patients.
  
  
  METHODS
  IMT was examined in 85 patients by ultrasonography at baseline and after 12 months. The difference in IMT between these two time points was calculated (DeltaIMT). We defined DeltaIMT< or =0.00 as 'progression', and DeltaIMT0.00 as 'stable'. Body fat distribution was calculated on computed tomography. Total adiponectin (T-Ad) and high molecular weight adiponectin (H-Ad) were measured by ELISA.
  
  
  RESULTS
  There were no significant differences between the two groups in all profiles except for the ratio of H-Ad to T-Ad (HMWR) at baseline. In the 'progression' group, IMT increased from 1.56+/-0.89 to 1.77+/-0.94 mm (p<0.001) and visceral fat area (60.3+/-30.7 to 69.2+/-37.5, cm2; p<0.01) increased. In the 'stable' group, HMWR increased from 31.3+/-5.4 to 37.6+/-7.3% (p<0.001). Multiple logistic regression analysis selected DeltaHMWR (p=0.031, odds ratio=0.928) independently of IMT progression. The correlation coefficient was -0.254 (p=0.019) between DeltaIMT and DeltaHMWR.
  
  
  CONCLUSIONS
  We found that an increase in HMWR was related to the stable state of IMT in HD patients.
authors.affiliation: Oyokyo Kidney Research Institute, Hirosaki, Japan. staff@oyokyo.jp
authors.forename: Megumi
authors.initials: M
authors.lastname: Tsushima
authors.forename: Yuriko
authors.initials: Y
authors.lastname: Terayama
authors.forename: Akishi
authors.initials: A
authors.lastname: Momose
authors.forename: Tomihisa
authors.initials: T
authors.lastname: Funyu
authors.forename: Chikara
authors.initials: C
authors.lastname: Ohyama
mesh_terms: D052242:Adiponectin / Q000502:physiology*; D000368:Aged; D050197:Atherosclerosis / Q000378:metabolism / Q000473:pathology*; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D017539:Tunica Intima / Q000000981:diagnostic imaging / Q000473:pathology*; D014463:Ultrasonography
chemical_list: D052242:Adiponectin