Biological properties of trabecular meshwork cells.
The molecular and physiological mechanisms that lead to the progression of glaucoma are poorly understood. Despite the fact that glaucoma afflicts millions of people worldwide, research on the disease is limited by the current animal models that do not translate well to human forms of the disease. However, recent advances in culturing and manipulating human trabecular meshwork cells may provide a means to elucidate some of the mechanisms that cause glaucoma. This review focuses on the properties of trabecular meshwork cells, from their characteristic expression profile in vivo to their responsiveness to biochemical and biophysical signals in vitro. Hopefully the study of cultured trabecular meshwork cells will provide a better understanding of glaucoma and lead to new, much needed therapies.
Gasiorowski
Joshua Z
JZ
School of Veterinary Medicine, University of Wisconsin-Madison, Department of Surgical Sciences, Madison, WI 53706, USA.
Russell
Paul
P
D018929:Cell Culture Techniques; D003907:Dexamethasone / Q000494:pharmacology; D005901:Glaucoma / Q000473:pathology; D005938:Glucocorticoids / Q000494:pharmacology; D006801:Humans; D040542:Mechanotransduction, Cellular / Q000502:physiology; D008954:Models, Biological; D018384:Oxidative Stress / Q000502:physiology; D010587:Phagocytosis; D014129:Trabecular Meshwork / Q000166:cytology* / Q000187:drug effects; D016212:Transforming Growth Factor beta / Q000494:pharmacology
D005938:Glucocorticoids; D016212:Transforming Growth Factor beta; D003907:Dexamethasone
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