Focusing on symptoms rather than diagnoses in brain dysfunction: conscious and nonconscious expression in impulsiveness and decision-making.
Symptoms and syndromes in neuropathology, whether expressed in conscious or nonconscious behaviour, remain imbedded in often complex diagnostic categories. Symptom-based strategies for studying brain disease states are driven by assessments of presenting symptoms, signs, assay results, neuroimages and biomarkers. In the present account, symptom-based strategies are contrasted with existing diagnostic classifications. Topics include brain areas and regional circuitry underlying decision-making and impulsiveness, and motor and learned expressions of explicit and implicit processes. In three self-report studies on young adult and adolescent healthy individuals, it was observed that linear regression analyses between positive and negative affect, self-esteem, four different types of situational motivation: intrinsic, identified regulation, extrinsic regulation and amotivation, and impulsiveness predicted significant associations between impulsiveness with negative affect and lack of motivation (i.e., amotivation) and internal locus of control, on the one hand, and non-impulsiveness with positive affect, self-esteem, and high motivation (i.e., intrinsic motivation and identified regulation), on the other. Although presymptomatic, these cognitive-affective characterizations illustrate individuals' choice behaviour in appraisals of situations, events and proclivities essentially of distal perspective. Neuropathological expressions provide the proximal realities of symptoms and syndromes with underlying dysfunctionality of brain regions, circuits and molecular mechanisms.
Palomo
T
T
Servicio Psiquiatrico, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.
Beninger
R J
RJ
Kostrzewa
R M
RM
Archer
T
T
D000293:Adolescent; D000328:Adult; D001526:Behavioral Symptoms / Q000209:etiology*; D001927:Brain Diseases / Q000150:complications* / Q000175:diagnosis*; D002648:Child; D003243:Consciousness; D003657:Decision Making; D005260:Female; D006801:Humans; D007175:Impulsive Behavior; D016014:Linear Models; D008297:Male; D055815:Young Adult
Addiction. 1998 May;93(5):729-38
9692271
Psychopharmacology (Berl). 2001 Jul;156(2-3):234-58
11549226
Neuropsychologia. 2002;40(5):471-8
11749977
Trends Neurosci. 1989 Oct;12(10):366-75
2479133
Am J Med Genet B Neuropsychiatr Genet. 2004 Apr 1;126B(1):37-42
15048645
Psychopharmacology (Berl). 2000 Nov;152(4):362-75
11140328
Alcohol Clin Exp Res. 2006 Nov;30(11):1866-70
17067350
Schizophr Bull. 2007 May;33(3):635-41
17412710
Nat Neurosci. 2000 Mar;3(3):211-6
10700251
Neurotox Res. 2007 Jan;11(1):41-50
17449447
Alcohol Clin Exp Res. 2000 May;24(5):611-21
10832902
Nurs Econ. 1997 Jul-Aug;15(4):183-90
9282030
Int J Epidemiol. 2002 Dec;31(6):1235-9
12540728
J Neurochem. 2004 Sep;90(6):1464-76
15341530
Science. 2004 Oct 15;306(5695):503-7
15486304
Learn Mem. 2006 Sep-Oct;13(5):650-8
17015860
Science. 1997 Feb 28;275(5304):1293-5
9036851
Science. 2004 Jun 25;304(5679):1979-83
15218151
Nat Neurosci. 2002 Nov;5(11):1103-4; author reply 1104
12403997
Pers Soc Psychol Rev. 2005;9(4):312-33
16223354
Occup Health Nurs. 1971 Nov;19(11):23-5 passim
4398942
Psychol Bull. 1975 Jul;82(4):463-96
1099599
Trends Cogn Sci. 2002 Oct 1;6(10):426-431
12413576
J Neurobiol. 2005 Jul;64(1):116-31
15883999
Schizophr Res. 2005 Jun 1;75(1):65-75
15820325
Addiction. 1999 May;94(5):697-707
10563034
Am J Psychiatry. 1997 Oct;154(10):1430-5
9326827
Int Rev Neurobiol. 2006;72:119-30
16697294
J Psychiatry Neurosci. 2008 Jan;33(1):47-53
18197272
Addict Behav. 1997 Jul-Aug;22(4):437-46
9290854
Br J Psychiatry. 1988 Feb;152:180-7
3167333
Neuropsychopharmacology. 2006 Jul;31(7):1393-405
16205781
Psychol Monogr. 1966;80(1):1-28
5340840
Brain Res. 1983 Oct;287(2):173-96
6357357
Psychiatry Res. 2001 Oct 10;104(1):27-37
11600187
Neurotox Res. 2008 Aug;14(1):57-70
18790725
J Pers Soc Psychol. 1994 Sep;67(3):357-65
7965599
Eur J Biochem. 1993 Apr 15;213(2):689-99
8386634
Psychiatry Res. 2006 Jan 30;146(1):1-11
16388934
Child Neuropsychol. 1999 Dec;5(4):230-41
10925707
Brain Cogn. 1999 Dec;41(3):351-64
10585241
Biol Psychiatry. 2001 Sep 15;50(6):418-24
11566158
Psychopharmacology (Berl). 2002 Dec;164(4):385-91
12457268
Brain Cogn. 2006 Mar;60(2):109-17
16481083
Psychol Med. 2002 Jan;32(1):105-17
11885567
J Pers Soc Psychol. 1988 Jun;54(6):1063-70
3397865
Mol Psychiatry. 2002;7(10):1039-53
12476318
Nat Neurosci. 2004 Aug;7(8):887-93
15235607
Psychopharmacology (Berl). 2004 Nov;176(2):182-94
15083253
Eur Psychiatry. 2006 Jun;21(4):270-3
16762532
Cell. 2006 May 19;125(4):785-99
16713568
Br J Clin Psychol. 1989 Feb;28(1):53-9
2522329
Psychiatry Res. 2005 Jun 30;135(3):191-201
15996748
Neurotox Res. 2007 Jul;12(1):43-60
17513199
Neuropsychologia. 2001;39(4):376-89
11164876
J Child Psychol Psychiatry. 2006 Mar-Apr;47(3-4):226-61
16492258
Brain. 2002 Mar;125(Pt 3):624-39
11872618
Pediatr Neurol. 2001 Sep;25(3):190-8
11587872
Cereb Cortex. 2006 Jan;16(1):106-14
15829733
J Int Neuropsychol Soc. 2006 Mar;12(2):210-23
16573855
Nat Rev Neurosci. 2003 Oct;4(10):829-39
14523382
Psychiatry Res. 2007 Jan 15;149(1-3):129-38
17046069
Neurotox Res. 2008 Aug;14(1):45-56
18790724
Biol Psychiatry. 2004 May 15;55(10):965-70
15121478
Ment Retard Dev Disabil Res Rev. 2000;6(2):142-7
10899808
Psychopharmacology (Berl). 2001 Jan;153(3):295-306
11271401
Neurotox Res. 2008 Aug;14(1):21-44
18790723
Hippocampus. 2001;11(6):776-82
11811672
J Neurosci. 2002 Jul 1;22(13):5619-29
12097513
Neuropsychologia. 2005;43(7):1099-106
15769495
Psychiatry Res. 1980 Oct;3(2):225-36
6171841
Psychophysiology. 1978 Mar;15(2):165-72
652911
Cereb Cortex. 2005 Jan;15(1):58-63
15217900
Biol Psychiatry. 2005 May 15;57(10):1209-11
15866563
Psychosom Med. 1964 Mar-Apr;26:125-34
14132974
Arch Neurol. 2004 May;61(5):641-4
15148138
J Psychopharmacol. 2003 Jun;17(2):216-22
12870570
Acta Psychiatr Scand. 2003 May;107(5):378-84
12752034
Neuropsychologia. 2000;38(8):1180-7
10838152
Science. 2005 Dec 9;310(5754):1624-5
16339434
Arch Gen Psychiatry. 1999 Apr;56(4):356-63
10197833
Arch Clin Neuropsychol. 2006 Feb;21(2):175-84
16307864
Annu Rev Neurosci. 2007;30:259-88
17600522
Br J Psychiatry. 2001 Apr;178:352-9
11282815
Arch Gen Psychiatry. 2005 Jul;62(7):799-805
15997022
Nature. 1995 Aug 17;376(6541):572-5
7637804
Alcohol Clin Exp Res. 2004 Nov;28(11):1657-65
15547452
Dialogues Clin Neurosci. 2006;8(1):9-16
16640109
Neuropsychologia. 2002;40(12):2013-22
12207998
Am J Ment Retard. 2007 Mar;112(2):79-93
17295556
Neurosci Biobehav Rev. 2007;31(4):597-618
17316796
Trends Cogn Sci. 2005 Aug;9(8):355-7
16006177
Br J Haematol. 1975 Oct;31(2):209-15
1201239
J Affect Disord. 2003 Jan;73(1-2):105-11
12507743
Science. 2003 Jun 13;300(5626):1755-8
12805551
Arch Gen Psychiatry. 2003 Jun;60(6):601-9
12796223
Neurotox Res. 2002 Aug-Sep;4(5-6):489-502
12754162
Hum Mol Genet. 2001 Jul 15;10(15):1611-7
11468279
Trends Neurosci. 2007 May;30(5):188-93
17368565
Mol Psychiatry. 2005 Aug;10(8):758-64
15940305
Pharmacopsychiatry. 2006 Feb;39 Suppl 1:S10-4
16508890
Brain. 2000 Nov;123 ( Pt 11):2189-202
11050020
Neuropsychology. 2003 Jul;17(3):420-8
12959508
Science. 2007 Nov 23;318(5854):1257
18033875
Int J Psychophysiol. 2006 Nov;62(2):203-11
16828187
Nat Neurosci. 1999 Nov;2(11):1032-7
10526345
Psychiatry Res. 2004 Jun 30;127(1-2):101-9
15261709
Ciba Found Symp. 1976 Dec 7-9;(51):201-25
1052031
J Abnorm Psychol. 1988 Aug;97(3):346-53
3192830
Mol Psychiatry. 2007 Jan;12(1):87-93
16969366
Pharmacol Biochem Behav. 1986 Jul;25(1):141-4
3018790
Cognition. 1994 Apr-Jun;50(1-3):7-15
8039375
Psychiatry Clin Neurosci. 2001 Apr;55(2):111-4
11285088
Am J Psychiatry. 2005 May;162(5):915-23
15863793
Alcohol Clin Exp Res. 2003 May;27(5):773-9
12766621
Nat Neurosci. 2005 Nov;8(11):1458-63
16251988
J Exp Psychol Learn Mem Cogn. 2003 Mar;29(2):224-34
12696811
Alcohol Alcohol. 2003 Jan-Feb;38(1):40-4
12554606
Nat Rev Neurosci. 2004 Nov;5(11):863-73
15496864
J Neurochem. 1986 Sep;47(3):794-9
2942640
Prog Neuropsychopharmacol Biol Psychiatry. 2005 Jun;29(5):713-7
15908092
Psychol Med. 2003 Nov;33(8):1335-40
14672242
Cell. 2006 Oct 6;127(1):49-58
17018276
Neuropsychology. 2005 Nov;19(6):799-805
16351355
J Pers Assess. 1996 Jun;66(3):488-524
8667144
J Biol Chem. 2006 Jul 7;281(27):18802-15
16651266
Cell. 2004 Feb 6;116(3):467-79
15016380
Prog Hematol. 1986;14:23-53
3511517
Alcohol Alcohol. 2003 Mar-Apr;38(2):151-6
12634263
Behav Neurosci. 2004 Dec;118(6):1324-30
15598141
Biol Psychiatry. 1997 May 15;41(10):1045-61
9129785
Addict Behav. 1999 May-Jun;24(3):449-53
10400285
Nature. 2004 Jul 22;430(6998):419-21
15269759
Schizophr Res. 2004 Aug 1;69(2-3):189-201
15469193
Neurotox Res. 2008 Aug;14(1):71-8
18790726
Cogn Affect Behav Neurosci. 2006 Jun;6(2):91-101
17007230
Eur J Neurosci. 1999 Aug;11(8):2906-16
10457187
Alcohol Clin Exp Res. 2004 Sep;28(9):1338-46
15365304
Bipolar Disord. 2004 Jun;6(3):204-12
15117399
Cogn Affect Behav Neurosci. 2002 Dec;2(4):341-53
12641178
Psychol Med. 2000 Sep;30(5):1025-36
12027040
Trends Neurosci. 1992 Sep;15(9):340-5
1382333
Alcohol Clin Exp Res. 2001 Feb;25(2):185-91
11236831
Lancet. 2005 Jul 16-22;366(9481):237-48
16023516
Alcohol Clin Exp Res. 2004 Apr;28(4):667-75
15100620
Neuropsychologia. 2004;42(11):1447-58
15246283
Ann N Y Acad Sci. 2007 Dec;1121:1-9
17846153
Conscious Cogn. 1999 Dec;8(4):497-509
10600247
Brain Cogn. 2005 Feb;57(1):21-5
15629209
Psychol Bull. 1984 Nov;96(3):465-90
6393179
Nebr Symp Motiv. 1990;38:237-88
2130258
J Clin Psychol. 2001 Jun;57(6):815-28
11344467
Neuron. 2006 Mar 2;49(5):765-75
16504951
Neuron. 2007 Aug 16;55(4):648-61
17698016
Psychol Sci. 2007 Nov;18(11):958-64
17958709
Psychopharmacology (Berl). 1999 Oct;146(4):348-61
10550486
Alcohol Alcohol. 2000 Jan;35(1):52-4
10684777
Arch Gen Psychiatry. 1990 Feb;47(2):181-8
2405807
Addiction. 2001 Jun;96(6):815-22
11399213
Neurotox Res. 2008 Oct;14(2-3):141-50
19073422
Trends Cogn Sci. 2006 Mar;10(3):108-16
16469524
J Clin Psychol. 1995 Nov;51(6):768-74
8778124
Behav Neurosci. 2000 Apr;114(2):374-88
10832798
J Neurosci. 1999 Jul 1;19(13):5473-81
10377356
Science. 2005 Dec 9;310(5754):1680-3
16339445
Annu Rev Pharmacol Toxicol. 1996;36:359-78
8725394
Trends Neurosci. 2007 May;30(5):194-202
17408759
Neuropsychopharmacology. 2002 Sep;27(3):421-9
12225699
Psychopharmacology (Berl). 2006 May;186(1):32-40
16557416
Behav Neurosci. 2001 Oct;115(5):993-1001
11584932
Nat Neurosci. 1999 Sep;2(9):844-7
10461225
Am Psychol. 1994 Aug;49(8):709-24
8092614
J Neurochem. 1958 Oct;3(1):41-51
13611557
Int J Dev Neurosci. 1986;4(1):81-8
2844061
Psychol Rev. 1999 Jan;106(1):3-19
10197361
Psychol Bull. 2001 May;127(3):291-324
11393298
Neuropsychopharmacology. 2006 Sep;31(9):2011-21
16482083
Psychiatry Res. 1997 Mar 24;69(2-3):89-95
9109176
Nat Rev Neurosci. 2006 Jan;7(1):54-64
16371950
J Neurosci. 2007 Jan 24;27(4):951-6
17251437
Am J Clin Nutr. 1989 Sep;50(3 Suppl):607-15; discussion 615-7
2773840
Behav Pharmacol. 2005 May;16(3):181-6
15864073
Psychopharmacology (Berl). 2000 Apr;149(2):147-52
10805609
Psychol Med. 2002 Apr;32(3):417-27
11989987
Biol Psychiatry. 2001 Nov 15;50(10):783-91
11720697
Psychopharmacology (Berl). 2007 Nov;194(4):545-54
17628790
Psychopharmacology (Berl). 2007 Sep;193(4):475-86
17492273
J Neural Transm (Vienna). 2001;108(6):617-27
11478414
Psychol Rev. 2006 Apr;113(2):300-326
16637763
Eur J Pharmacol. 1984 Sep 17;104(3-4):245-51
6094214
Alcohol Clin Exp Res. 2007 Jul;31(7):1169-78
17511749
Cleft Palate J. 1978 Jan;15(1):56-62
272242
Psychiatry Res. 2007 Apr 15;150(3):245-53
17316823
Psychopharmacology (Berl). 2000 May;150(1):90-101
10867981
Neurosci Lett. 2002 Aug 16;328(3):233-6
12147314
Brain Cogn. 1993 Jul;22(2):244-65
8373576
Trends Cogn Sci. 2007 Jun;11(6):258-65
17475537
Trends Cogn Sci. 2005 Apr;9(4):159-62; discussion 162-4
15808493
Neuropsychopharmacology. 2008 Feb;33(3):497-512
17460616
Acta Neuropsychiatr. 2007 Aug;19(4):244-50
26952891
Mol Psychiatry. 1999 Jul;4(4):385-8
10483057
Neurotox Res. 2004;6(3):159-73
15325956
J Neurosci. 1997 Apr 1;17(7):2626-36
9065522
Neuroscience. 2003;116(3):743-52
12573716
Cell Mol Biol (Noisy-le-grand). 2000 Jun;46(4):743-60
10875437
Int J Neuropsychopharmacol. 2007 Jun;10(3):383-99
16925890
Psychopharmacology (Berl). 1999 Oct;146(4):400-12
10550490
Brain Cogn. 2004 Jun;55(1):41-53
15134842
Conscious Cogn. 2006 Jun;15(2):372-85
16289992
Psychopharmacology (Berl). 2001 Jul;156(2-3):284-90
11549230
Psychiatry Res. 2006 Sep 30;144(1):1-15
16914207
Psychiatry Res. 2000 Apr 24;94(1):9-18
10788673
Nat Neurosci. 2005 Sep;8(9):1255-62
16116457
Mol Psychiatry. 2003 Apr;8(4):445-52
12740602
J Abnorm Psychol. 1971 Jun;77(3):223-35
5556930
J Abnorm Psychol. 1957 Jul;55(1):6-10
13462652
Psychopharmacology (Berl). 2005 Jun;180(1):57-62
15650841
Psychopharmacology (Berl). 2005 Nov;182(4):570-8
16163530
Psychol Med. 2001 May;31(4):679-93
11352370
Cereb Cortex. 1996 Mar-Apr;6(2):215-25
8670652
Science. 2006 Aug 4;313(5787):684-7
16888142
Neuropsychologia. 2006;44(8):1315-24
16513144
Cell Mol Biol (Noisy-le-grand). 2000 May;46(3):491-500
10872737
Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):11032-7
11005874
Neuropsychologia. 2002;40(10):1675-89
11992656