Insights from experimental studies into allodynia and its treatment.
Migraine is a common disorder that often is accompanied by cutaneous allodynia. Cutaneous allodynia on the head has been linked to sensitization of neurons in the trigeminal nucleus caudalis in animal models of migraine. In addition, migraine with allodynia is refractory to acute treatment with triptans. Understanding the mechanisms of allodynia, preventing its development, and finding effective treatments have become a priority in headache research. This paper reviews recent research on the pathogenesis of headache and the generation of allodynia. We discuss the regions of the nervous system that are involved in generating and maintaining headache pain and allodynia. We also discuss recent advances in the treatment of migraine based on translation research.
Oshinsky
Michael L
ML
Department of Neurology, Thomas Jefferson University, 1020 Locust Street, Suite 398 JAH, Philadelphia, PA 19107, USA. michael.oshinsky@jefferson.edu
D000700:Analgesics / Q000627:therapeutic use; D000818:Animals; D004351:Drug Resistance; D006801:Humans; D006930:Hyperalgesia / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*; D008881:Migraine Disorders / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy*
D000700:Analgesics
J Neurol Neurosurg Psychiatry. 1960 Feb;23:23-32
14444681
Eur J Pain. 2003;7(4):345-51
12821405
Curr Pharm Des. 2005;11(23):2961-76
16178756
Pain. 1991 Mar;44(3):293-299
1828878
Pain. 2003 Apr;102(3):283-288
12670670
Neurosci Lett. 2004 Sep 16;368(1):82-6
15342139
Stroke. 2002 Dec;33(12):3030-2
12468808
Nature. 1996 Dec 12;384(6609):560-4
8955268
Brain Res. 2005 Jun 28;1048(1-2):218-27
15922311
Funct Neurol. 2000;15 Suppl 3:28-35
11200798
Yonsei Med J. 2002 Jun;43(3):370-6
12089747
Science. 1981 Sep 25;213(4515):1527-9
7280675
Neurology. 2005 Aug 9;65(3):444-7
16087911
J Pharmacol Exp Ther. 2005 Mar;312(3):1161-9
15572651
Neurology. 2005 May 24;64(10 Suppl 2):S16-20
15911782
Joint Bone Spine. 2005 Oct;72(5):359-71
16214069
Rev Neurol (Paris). 2005 Jul;161(6-7):658-60
16141951
Brain. 2001 Dec;124(Pt 12):2490-502
11701602
Pain Suppl. 1986;3:S1-226
3461421
Brain. 1984 Dec;107 ( Pt 4):1179-88
6509313
Pain. 2001 Jan;89(2-3):107-10
11166465
Eur Neurol. 1996;36 Suppl 2:28-31
8791030
Pain. 2004 Jan;107(1-2):33-40
14715386
Neurology. 1986 Jul;36(7):995-7
3520384
Ann Neurol. 2000 May;47(5):614-24
10805332
Pain. 1999 Feb;79(2-3):105-11
10068155
Headache. 1987 Jan;27(1):45-50
3557962
J Neurosci. 2003 Nov 26;23(34):10988-97
14645495
Brain Res Bull. 2002 Sep 30;58(6):561-7
12372559
Brain Res Brain Res Rev. 2004 Nov;46(3):295-309
15571771
Cerebrovasc Brain Metab Rev. 1993 Fall;5(3):159-77
8217498
Neuropharmacology. 2005 Feb;48(2):252-63
15695164
Neurosci Lett. 2002 Apr 19;323(1):75-7
11911993
J Neurophysiol. 1998 Feb;79(2):964-82
9463456
Eur J Neurol. 2004 Oct;11(10):671-7
15469451
Pain. 2003 May;103(1-2):75-81
12749961
Neuroreport. 1996 Jan 31;7(2):526-8
8730821
Acta Neurol Scand Suppl. 1993;147:1-27
7694438
Life Sci. 2004 Oct 8;75(21):2527-38
15363658
Headache. 1981 Mar;21(2):49-54
7239900
Neuropharmacology. 2004 Aug;47(2):175-83
15223296
Trends Neurosci. 2003 Dec;26(12):696-705
14624855
J Neurophysiol. 2005 Sep;94(3):1659-63
16105951
Lancet. 1999 Jun 19;353(9170):2145-8
10382712
Prog Neurobiol. 1992;38(4):397-421
1574584
Brain. 2000 Aug;123 ( Pt 8):1703-9
10908199
BMC Neurol. 2006 Jan 04;6:1
16393343
Br J Pharmacol. 2001 Jun;133(4):586-94
11399676
J Neurophysiol. 2000 Oct;84(4):2078-112
11024099
Ann Neurol. 2004 Sep;56(3):371-81
15349864
Cephalalgia. 2005 Sep;25(9):735-42
16109056
J Neurophysiol. 1999 Feb;81(2):479-93
10036252
Pain. 1999 Feb;79(2-3):281-90
10068174
Anesth Analg. 2005 Sep;101(3):800-806
16115994
Neurology. 1994 Sep;44(9):1587-92
7936279
J Comp Neurol. 1996 Sep 30;373(4):549-74
8889944
Headache. 2005 Jul-Aug;45(7):850-61
15985101
J Comp Neurol. 2005 Dec 5;493(1):9-14
16258903