title: Ezetimibe alone reduces low-density lipoprotein cholesterol in HIV-infected patients receiving combination antiretroviral therapy.
abstract: In this crossover study of ezetimibe monotherapy in 48 antiretroviral-treated patients with human immunodeficiency virus infection, the mean changes in low-density lipoprotein cholesterol were -5.3% (-11 mg/dL) and +5.5% (+4 mg/dL) with ezetimibe treatment and placebo, respectively (P = .04). Ezetimibe was safe and effective in reducing low-density lipoprotein cholesterol and is an option for patients who cannot tolerate treatment with a statin.
authors.affiliation: University of North Carolina, Chapel Hill, NC 27599, USA. wohl@med.unc.edu
authors.forename: David A
authors.initials: DA
authors.lastname: Wohl
authors.forename: David
authors.initials: D
authors.lastname: Waters
authors.forename: Ross J
authors.initials: RJ
authors.lastname: Simpson
authors.forename: Susan
authors.initials: S
authors.lastname: Richard
authors.forename: Amanda
authors.initials: A
authors.lastname: Schnell
authors.forename: Sonia
authors.initials: S
authors.lastname: Napravnik
authors.forename: Jessica
authors.initials: J
authors.lastname: Keys
authors.forename: J Joseph
authors.initials: JJ
authors.lastname: Eron
authors.forename: Priscilla
authors.initials: P
authors.lastname: Hsue
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000494:pharmacology*; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D001384:Azetidines / Q000494:pharmacology*; D008078:Cholesterol, LDL / Q000097:blood*; D000069438:Ezetimibe; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D006937:Hypercholesterolemia / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D010919:Placebos / Q000008:administration & dosage
chemical_list: D019380:Anti-HIV Agents; D001384:Azetidines; D008078:Cholesterol, LDL; D010919:Placebos; D000069438:Ezetimibe
references.citation: HIV Med. 2005 Jan;6(1):37-44
references.pmid: 15670251
references.citation: Lancet. 2006 Aug 5;368(9534):476-82
references.pmid: 16890834
references.citation: AIDS. 2006 Nov 14;20(17):2159-64
references.pmid: 17086055
references.citation: N Engl J Med. 2006 Jan 19;354(3):251-60
references.pmid: 16421366
references.citation: PLoS Med. 2004 Oct;1(1):e19
references.pmid: 15526045
references.citation: JAMA. 2004 Jul 14;292(2):191-201
references.pmid: 15249568
references.citation: JAMA. 2001 May 16;285(19):2486-97
references.pmid: 11368702
references.citation: N Engl J Med. 2007 Apr 26;356(17):1723-35
references.pmid: 17460226
references.citation: J Am Coll Cardiol. 2004 Aug 4;44(3):720-32
references.pmid: 15358046
references.citation: N Engl J Med. 2008 Apr 3;358(14):1431-43
references.pmid: 18376000
references.citation: N Engl J Med. 2003 Nov 20;349(21):1993-2003
references.pmid: 14627784
references.citation: AIDS. 2006 Aug 1;20(12):1675-7
references.pmid: 16868453
references.citation: J Clin Endocrinol Metab. 2007 Jul;92(7):2506-12
references.pmid: 17456578
references.citation: Lipids Health Dis. 2007 Jun 13;6:15
references.pmid: 17565701