A novel synthesis of 1-nosyl 3,3-dichloro-beta-lactams and derivatives.
We report herein an efficient and simple route to synthesize 1-nosyl 3,3-dichloro-beta-lactams using a Staudinger reaction between N-nosyl imines and dichloroketene. The resulting dichloroazetidines were opened to afford highly functionalized building blocks.
Tato
Francisco
F
Laboratoire de Chimie Moléculaire et Thio-organique, ENSICAEN, Université de Caen Basse-Normandie, CNRS, 6, Boulevard du Maréchal Juin, 14050, Caen, France.
Reboul
Vincent
V
Metzner
Patrick
P
D001384:Azetidines; D005030:Ethylenes / Q000737:chemistry; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry; D007097:Imines / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D047090:beta-Lactams / Q000138:chemical synthesis*
D001384:Azetidines; D005030:Ethylenes; D006843:Hydrocarbons, Chlorinated; D007097:Imines; D007659:Ketones; D047090:beta-Lactams; C008223:ketene