Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13.
The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.
Barton
Anne
A
Arthritis Research Campaign, Epidemiology Unit, The University of Manchester, Manchester, UK. anne.barton@manchester.ac.uk
Thomson
Wendy
W
Ke
Xiayi
X
Eyre
Steve
S
Hinks
Anne
A
Bowes
John
J
Plant
Darren
D
Gibbons
Laura J
LJ
Wilson
Anthony G
AG
Bax
Deborah E
DE
Morgan
Ann W
AW
Emery
Paul
P
Steer
Sophia
S
Hocking
Lynne
L
Reid
David M
DM
Wordsworth
Paul
P
Harrison
Pille
P
Worthington
Jane
J
D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics*; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics*; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
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