title: Psychiatric disorder in young adults born very preterm: role of family history.
abstract: OBJECTIVE
  To investigate whether young adults born very preterm (VPT) (<33 weeks) are at increased risk for psychiatric illness in adulthood and whether a family history of psychiatric disorder further increases this risk.
  
  
  METHODS
  We assessed 169 VPT and 101 term born individuals using the Clinical Interview Schedule - Revised.
  
  
  RESULTS
  Young adults born VPT had an increased risk for psychiatric disorder compared to controls (OR=3.1, 95% CI=1.1-8.6, p=0.03). Those born VPT who had a history of psychiatric disorder in a first-degree relative, had an increase in risk for psychiatric disorder compared to those born VPT without a family history (OR=5.2, 95% CI=1.8-14.9, p=0.002).
  
  
  CONCLUSIONS
  Individuals born VPT are at increased risk of psychiatric illness in young adulthood compared to controls. In addition, a family history of psychiatric disorder in a first-degree relative may leave young adults born VPT particularly vulnerable to psychiatric illness.
authors.affiliation: NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, King's College London, De Crespigny Park, London, SE5 8AF, UK. m.walshe@iop.kcl.ac.uk
authors.forename: M
authors.initials: M
authors.lastname: Walshe
authors.forename: L
authors.initials: L
authors.lastname: Rifkin
authors.forename: M
authors.initials: M
authors.lastname: Rooney
authors.forename: E
authors.initials: E
authors.lastname: Healy
authors.forename: C
authors.initials: C
authors.lastname: Nosarti
authors.forename: J
authors.initials: J
authors.lastname: Wyatt
authors.forename: D
authors.initials: D
authors.lastname: Stahl
authors.forename: R M
authors.initials: RM
authors.lastname: Murray
authors.forename: M
authors.initials: M
authors.lastname: Allin
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D001523:Mental Disorders / Q000453:epidemiology* / Q000235:genetics*; D055815:Young Adult