title: Cancer of the larynx in Puerto Rico.
abstract: BACKGROUND
  Cancer of the larynx is the fourteenth most common cancer in the world. The purpose of this cross-sectional study is to examine the characteristics of laryngeal cancer in Puerto Rico. The study evaluates whether this type of cancer is increasing, to what degree gender differences occur; and describe common types of medical treatment.
  
  
  METHODS
  Information on cases of laryngeal cancer for the period of 1997 to 2002 was collected at the Puerto Rico Central Cancer Registry, Department of Health. The incidence of laryngeal cancer in Puerto Rico during the study period was estimated. Sex differences in case-fatality rate and other variables were analyzed. Medical treatments for laryngeal cancer were also analyzed.
  
  
  RESULTS
  The study revealed that the average incidence of laryngeal cancer in Puerto Rico was 3.8 x 100,000 from 1997-1998 and 3.5 x 100,000 from 2001-2002 (-1.07 APC). Of all the cases (n = 848) of laryngeal cancer reviewed, 88% were male. Females were more likely to be diagnosed before age 50 than males (p = 0.02). In this study, women had twice the probability of being alive at the end of the study period (OR = 1.97; CI: 1.14-3.45). The two most frequent types of single treatments for laryngeal cancer were radiation (39%) and surgery (33%).
  
  
  CONCLUSIONS
  Cases oflaryngeal cancer are decreasing in Puerto Rico. Significant differences by sex were observed, especially the stage of the disease at the time of diagnosis. Future studies on medical treatment modalities that better preserve vocal function concurrently with voice therapy are recommended.
authors.affiliation: University of Puerto Rico, Medical Sciences Campus, School of Health Professions, Department of Graduate Programs, Speech-Language Pathology Programs, PO Box 365067, San Juan, PR 00936-5067. albertvillanueva@cprs.rcm.upr.edu
authors.forename: Albert
authors.initials: A
authors.lastname: Villanueva-Reyes
authors.forename: Edythe
authors.initials: E
authors.lastname: Strand
authors.forename: Cruz María
authors.initials: CM
authors.lastname: Nazario
authors.forename: Margarita
authors.initials: M
authors.lastname: Irizarry-Ramírez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011647:Puerto Rico / Q000453:epidemiology; D012737:Sex Factors
references.citation: Laryngoscope. 2003 Sep;113(9):1595-9
references.pmid: 12972940
references.citation: P R Health Sci J. 1996 Dec;15(4):251-5
references.pmid: 9097341
references.citation: N Engl J Med. 2003 Nov 27;349(22):2091-8
references.pmid: 14645636
references.citation: Int J Epidemiol. 1993 Jun;22(3):377-84
references.pmid: 8359951
references.citation: Laryngoscope. 2004 Nov;114(11):1880-91
references.pmid: 15510009
references.citation: Med Arh. 2005;59(4):250-4
references.pmid: 16018395
references.citation: Am J Otolaryngol. 2006 Jan-Feb;27(1):1-4
references.pmid: 16360814
references.citation: Tumori. 2006 Jan-Feb;92(1):72-5
references.pmid: 16683387
references.citation: Eur J Surg Oncol. 2006 Nov;32(9):984-8
references.pmid: 16626921
references.citation: Sao Paulo Med J. 2004 Sep 2;122(5):188-94
references.pmid: 15558139
references.citation: Arch Bronconeumol. 2005 Jun;41(6):307-12
references.pmid: 15989887
references.citation: P R Health Sci J. 2003 Sep;22(3):259-64
references.pmid: 14619452
references.citation: B-ENT. 2005;1(2):97-100
references.pmid: 16044742
references.citation: Asian Pac J Cancer Prev. 2005 Apr-Jun;6(2):202-7
references.pmid: 16101334
references.citation: N Engl J Med. 1991 Jun 13;324(24):1685-90
references.pmid: 2034244
references.citation: J Chin Med Assoc. 2006 Mar;69(3):120-4
references.pmid: 16599017
references.citation: Int J Radiat Oncol Biol Phys. 2005 Dec 1;63(5):1378-86
references.pmid: 16095847
references.citation: Bosn J Basic Med Sci. 2004 Oct;4(4):25-7
references.pmid: 15628992
references.citation: Neoplasma. 2005;52(6):483-8
references.pmid: 16284693
references.citation: J Appl Genet. 2005;46(4):407-13
references.pmid: 16278516
references.citation: Int J Cancer. 2005 Sep 1;116(3):451-7
references.pmid: 15810012