title: Weight regain is related to decreases in physical activity during weight loss.
abstract: OBJECTIVE
  To examine whether adaptations in physical activity energy expenditure (PAEE) and resting metabolic rate (RMR) during weight loss were associated with future weight regain in overweight/obese, older women.
  
  
  METHODS
  Thirty-four overweight/obese (BMI = 25-40 kg x m(-2)), postmenopausal women underwent a 20-wk weight loss intervention of hypocaloric diet with (low- or high-intensity) or without treadmill walking (weekly caloric deficit was approximately 11,760 kJ), with a subsequent 12-month follow-up. RMR (via indirect calorimetry), PAEE (by RT3 accelerometer), and body composition (by dual-energy x-ray absorptiometry) were measured before and after intervention. Body weight and self-reported information on physical activity were collected after intervention and at 6 and 12 months after intervention.
  
  
  RESULTS
  The intervention resulted in decreases in body weight, lean mass, fat mass, percent body fat, RMR, and PAEE (P < 0.001 for all). Weight regain was 2.9 +/- 3.3 kg (-3.1 to +9.2 kg) at 6 months and 5.2 +/- 5.0 kg (-2.3 to +21.7 kg) at 12 months after intervention. The amount of weight regained after 6 and 12 months was inversely associated with decreases in PAEE during the weight loss intervention (r = -0.521, P = 0.002 and r = -0.404, P = 0.018, respectively), such that women with larger declines in PAEE during weight loss experienced greater weight regain during follow-up. Weight regain was not associated with changes in RMR during intervention or with self-reported physical activity during follow-up.
  
  
  CONCLUSIONS
  This study demonstrates that although both RMR and PAEE decreased during weight loss in postmenopausal women, maintaining high levels of daily physical activity during weight loss may be important to mitigate weight regain after weight loss.
authors.affiliation: Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. xwang@wfubmc.edu
authors.forename: Xuewen
authors.initials: X
authors.lastname: Wang
authors.forename: Mary F
authors.initials: MF
authors.lastname: Lyles
authors.forename: Tongjian
authors.initials: T
authors.lastname: You
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Berry
authors.forename: W Jack
authors.initials: WJ
authors.lastname: Rejeski
authors.forename: Barbara J
authors.initials: BJ
authors.lastname: Nicklas
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D001481:Basal Metabolism; D001823:Body Composition; D031204:Caloric Restriction; D015444:Exercise; D005260:Female; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause; D015430:Weight Gain; D015431:Weight Loss
references.citation: Am J Clin Nutr. 2005 Jul;82(1 Suppl):222S-225S
references.pmid: 16002825
references.citation: Am J Clin Nutr. 1990 Apr;51(4):578-83
references.pmid: 2321566
references.citation: Am J Clin Nutr. 2002 Mar;75(3):499-504
references.pmid: 11864855
references.citation: Ann Med Exp Biol Fenn. 1957;35(3):307-15
references.pmid: 13470504
references.citation: J Clin Epidemiol. 1993 Feb;46(2):153-62
references.pmid: 8437031
references.citation: Am J Clin Nutr. 1999 Jun;69(6):1189-93
references.pmid: 10357738
references.citation: Int J Obes Relat Metab Disord. 2000 Apr;24(4):395-403
references.pmid: 10805494
references.citation: Arch Intern Med. 2000 Jul 24;160(14):2177-84
references.pmid: 10904461
references.citation: Annu Rev Nutr. 2001;21:323-41
references.pmid: 11375440
references.citation: J Am Diet Assoc. 1993 Sep;93(9):1017-24
references.pmid: 8360406
references.citation: Int J Obes Relat Metab Disord. 1993 May;17(5):279-86
references.pmid: 8389337
references.citation: Am J Clin Nutr. 1998 Oct;68(4):956S-961S
references.pmid: 9771879
references.citation: N Engl J Med. 1988 Feb 25;318(8):467-72
references.pmid: 3340128
references.citation: Obes Res. 1999 Jan;7(1):43-50
references.pmid: 10023729
references.citation: Obesity (Silver Spring). 2006 Apr;14(4):710-6
references.pmid: 16741274
references.citation: Am J Clin Nutr. 1997 Sep;66(3):551-6
references.pmid: 9280172
references.citation: Am J Clin Nutr. 2000 May;71(5):1138-46
references.pmid: 10799376
references.citation: Am J Clin Nutr. 2000 Nov;72(5):1088-94
references.pmid: 11063433
references.citation: Am J Epidemiol. 1990 Jul;132(1):107-13
references.pmid: 2192545
references.citation: Int J Obes Relat Metab Disord. 1992 Sep;16(9):667-74
references.pmid: 1328091
references.citation: Metabolism. 1988 Oct;37(10):930-6
references.pmid: 3173112
references.citation: Int J Obes Relat Metab Disord. 2004 Apr;28(4):514-9
references.pmid: 14968129
references.citation: J Am Diet Assoc. 2005 May;105(5 Suppl 1):S63-6
references.pmid: 15867898
references.citation: Int J Obes Relat Metab Disord. 2000 Jan;24(1):55-9
references.pmid: 10702751
references.citation: Br J Nutr. 1998 Dec;80(6):511-9
references.pmid: 10211049
references.citation: Am J Clin Nutr. 1956 Mar-Apr;4(2):169-75
references.pmid: 13302165
references.citation: J Am Diet Assoc. 2002 Sep;102(9):1252-6
references.pmid: 12792622
references.citation: Obes Rev. 2000 May;1(1):21-6
references.pmid: 12119641
references.citation: Am J Physiol. 1992 Aug;263(2 Pt 1):E296-300
references.pmid: 1514610
references.citation: Obes Res. 1998 Sep;6 Suppl 2:51S-209S
references.pmid: 9813653
references.citation: J Sports Med Phys Fitness. 1999 Dec;39(4):336-40
references.pmid: 10726435
references.citation: Med Sci Sports Exerc. 2001 Dec;33(12):2145-56
references.pmid: 11740312
references.citation: J Clin Epidemiol. 1997 May;50(5):541-6
references.pmid: 9180646
references.citation: Obes Rev. 2005 Feb;6(1):67-85
references.pmid: 15655039
references.citation: Ann Intern Med. 1993 Oct 1;119(7 Pt 2):764-70
references.pmid: 8363212
references.citation: Curr Opin Clin Nutr Metab Care. 2004 Nov;7(6):599-605
references.pmid: 15534426
references.citation: N Engl J Med. 1995 Mar 9;332(10):621-8
references.pmid: 7632212