title: Diagnostic significance of serum glycated albumin in diabetic dogs.
abstract: Measurements of serum fructosamine, glycated hemoglobin, and glycated albumin (GA) are increasingly used to complement serum glucose concentration for better management of diabetes mellitus. Fructosamine tests are currently not performed in veterinary medicine in Japan. As such, the measurement of GA may serve as a replacement test. Therefore, in the current study, serum GA and fructosamine were evaluated for a positive correlation in dogs, and, depending on the correlation, a reference range of GA percentage would also be determined from healthy control dogs. The degree of glycemic control in diabetic dogs was determined by fructosamine concentration. A positive correlation between GA and fructosamine was observed with both normal and diabetic animals. In addition, the reference interval of serum GA percentage in control dogs was determined to be 11.4-11.9% (95% confidence interval). Interestingly, no significant difference in serum GA percentages was observed between samples from diabetic dogs with excellent glycemic control and control dogs. However, good, fair, and poor glycemic control diabetic dogs resulted in a significant increase in serum GA percentages in comparison with control dogs. These results suggest that serum GA may be a useful diagnostic indicator, substituting for fructosamine, to monitor glycemic control in diabetic dogs.
authors.affiliation: Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino, Tokyo, Japan.
authors.forename: Toshinori
authors.initials: T
authors.lastname: Sako
authors.forename: Akihiro
authors.initials: A
authors.lastname: Mori
authors.forename: Peter
authors.initials: P
authors.lastname: Lee
authors.forename: Tomoya
authors.initials: T
authors.lastname: Takahashi
authors.forename: Takehito
authors.initials: T
authors.lastname: Izawa
authors.forename: Sino
authors.initials: S
authors.lastname: Karasawa
authors.forename: Miho
authors.initials: M
authors.lastname: Furuuchi
authors.forename: Daigo
authors.initials: D
authors.lastname: Azakami
authors.forename: Mina
authors.initials: M
authors.lastname: Mizukoshi
authors.forename: Hisashi
authors.initials: H
authors.lastname: Mizutani
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kiyosawa
authors.forename: Toshiro
authors.initials: T
authors.lastname: Arai
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood / Q000662:veterinary*; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D005260:Female; D019270:Fructosamine / Q000097:blood; D017127:Glycation End Products, Advanced; D008297:Male; D009919:Orchiectomy / Q000662:veterinary; D010052:Ovariectomy / Q000662:veterinary; D012709:Serum Albumin / Q000378:metabolism*; D013045:Species Specificity; D000093423:Glycated Serum Albumin
chemical_list: D015415:Biomarkers; D017127:Glycation End Products, Advanced; D012709:Serum Albumin; D019270:Fructosamine; D000093423:Glycated Serum Albumin