A bifurcated pathway to thiazoles and imidazoles using a modular flow microreactor.
A scalable method for the preparation of 4,5-disubstituted thiazoles and imidazoles as distinct regioisomeric products using a modular flow microreactor has been devised. The process makes use of microfluidic reaction chips and packed immobilized-reagent columns to effect bifurcation of the reaction pathway.
Baxendale
Ian R
IR
Innovative Technology Centre (ACS), Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, U.K.
Ley
Steven V
SV
Smith
Christopher D
CD
Tamborini
Lucia
L
Voica
Ana-Florina
AF
D020650:Combinatorial Chemistry Techniques; D007093:Imidazoles / Q000138:chemical synthesis*; D008832:Microchemistry / Q000379:methods; D046210:Microfluidic Analytical Techniques / Q000379:methods*; D013844:Thiazoles / Q000138:chemical synthesis*
D007093:Imidazoles; D013844:Thiazoles