title: Targeting glycogen synthase kinase-3 (GSK-3) in the treatment of Type 2 diabetes.
abstract: BACKGROUND
  In spite of its rather specific name, glycogen synthase kinase-3 (GSK-3) is an eclectic cellular regulator that modulates an array of processes from nuclear transcription, to neurological functions and metabolism. The enzyme is also a focal point for diverse signaling pathways that act to suppress its activity.
  
  
  OBJECTIVE
  To review recent evidence supporting the important role GSK-3 plays in glucose homeostasis and discuss the therapeutic potential of inhibiting this enzyme in the treatment of diabetes and insulin resistance.
  
  
  CONCLUSIONS
  Despite its pleiotropic nature, GSK-3 has significant promise as a target for diabetes due to functional partitioning of the enzyme, tissue-selectivity and acute dosage-dependency of effects of inhibition, suggesting useful therapeutic windows.
authors.affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
authors.forename: Katrina
authors.initials: K
authors.lastname: MacAulay
authors.forename: James R
authors.initials: JR
authors.lastname: Woodgett
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D038362:Glycogen Synthase Kinase 3 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000502:physiology; D007333:Insulin Resistance; D015398:Signal Transduction; D013379:Substrate Specificity
chemical_list: D004791:Enzyme Inhibitors; D007328:Insulin; D038362:Glycogen Synthase Kinase 3
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