title: Current views of the risk of stroke for migraine with and migraine without aura.
abstract: The association between migraine and stroke is complex and is a continued focus of attention. Several observational studies have identified migraine as an independent risk factor for ischemic stroke. However, a distinction should be made between migraine with and migraine without aura. The migraine-stroke association is mostly apparent for young women with migraine with aura. The association between migraine with aura and stroke is weaker in older age groups, which may be due to the fact that traditional cardiovascular risk factors are more prominent with increasing age. Most studies have not found an association between migraine without aura and ischemic stroke. Although there are several hypotheses about the biologic link between migraine with aura and ischemic stroke, the precise mechanisms remain unclear. However, because the absolute risk of stroke is low in patients with migraine with aura, and migraine without aura is likely not associated with ischemic stroke, most migraine patients will not experience a stroke event.
authors.affiliation: Division of Aging, Brigham and Women's Hospital, 1620 Tremont Street, Boston, MA 02120, USA. tkurth@rics.bwh.harvard.edu
authors.forename: Tobias
authors.initials: T
authors.lastname: Kurth
authors.forename: Hans-Christoph
authors.initials: HC
authors.lastname: Diener
mesh_terms: D006801:Humans; D020325:Migraine with Aura / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D020326:Migraine without Aura / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D012307:Risk Factors; D020521:Stroke / Q000209:etiology*
references.citation: Headache. 2004 Jul-Aug;44(7):642-51
references.pmid: 15209685
references.citation: Neurology. 1999 May 12;52(8):1622-5
references.pmid: 10331688
references.citation: Neurology. 1989 Sep;39(9):1239-42
references.pmid: 2475821
references.citation: Arch Neurol. 1997 Apr;54(4):362-8
references.pmid: 9109736
references.citation: JAMA. 1975 Feb 17;231(7):718-22
references.pmid: 1172861
references.citation: Heart. 2004 Nov;90(11):1315-20
references.pmid: 15486131
references.citation: Cephalalgia. 2004;24 Suppl 1:9-160
references.pmid: 14979299
references.citation: Cephalalgia. 2002 Mar;22(2):107-11
references.pmid: 11972577
references.citation: Headache. 2004 May;44 Suppl 1:S5-12
references.pmid: 15149488
references.citation: Neurology. 2002 Aug 13;59(3):435-7
references.pmid: 12177380
references.citation: Neurology. 2001 Nov 27;57(10):1805-11
references.pmid: 11723268
references.citation: Stroke. 2005 Feb;36(2):e1-3
references.pmid: 15604424
references.citation: Stroke. 2004 Jul;35(7):1574-8
references.pmid: 15143296
references.citation: Neurology. 1998 Nov;51(5):1465-9
references.pmid: 9818884
references.citation: Am J Med. 2005 Mar;118 Suppl 1:36S-44S
references.pmid: 15841886
references.citation: Ann Neurol. 1984 Oct;16(4):481-8
references.pmid: 6093682
references.citation: Arch Neurol. 1995 Feb;52(2):129-34
references.pmid: 7848119
references.citation: Lancet Neurol. 2005 Sep;4(9):533-42
references.pmid: 16109360
references.citation: Arch Neurol. 1990 Apr;47(4):458-62
references.pmid: 2181979
references.citation: Ann Neurol. 1998 Jan;43(1):25-31
references.pmid: 9450765
references.citation: BMJ. 2005 Jan 8;330(7482):63
references.pmid: 15596418
references.citation: Br J Obstet Gynaecol. 1995 Feb;102(2):153-9
references.pmid: 7756208
references.citation: Headache. 1998 Nov-Dec;38(10):779-81
references.pmid: 11279903
references.citation: Cephalalgia. 2001 Mar;21(2):120-8
references.pmid: 11422094
references.citation: Am J Med. 2005 Mar;118 Suppl 1:3S-10S
references.pmid: 15841882
references.citation: JAMA. 1992 Jan 1;267(1):64-9
references.pmid: 1727198
references.citation: Neurology. 2005 Mar 22;64(6):1020-6
references.pmid: 15781820
references.citation: Brain. 1998 Feb;121 ( Pt 2):303-16
references.pmid: 9549508
references.citation: Cephalalgia. 2002 May;22(4):303-8
references.pmid: 12100093
references.citation: N Engl J Med. 1994 Dec 22;331(25):1689-92
references.pmid: 7969360
references.citation: Neurology. 2005 May 24;64(10 Suppl 2):S9-15
references.pmid: 15911785
references.citation: BMJ. 1995 Apr 1;310(6983):830-3
references.pmid: 7711619
references.citation: BMJ. 1999 Jan 2;318(7175):13-8
references.pmid: 9872876
references.citation: Lancet. 2000 Nov 11;356(9242):1648-51
references.pmid: 11089825
references.citation: Neurology. 2001 Jul 24;57(2):334-6
references.pmid: 11468324
references.citation: Neuroepidemiology. 1999;18(2):85-91
references.pmid: 10023131
references.citation: Headache. 1989 Oct;29(9):560-1
references.pmid: 2583992
references.citation: Stroke. 1997 Jan;28(1):26-30
references.pmid: 8996483
references.citation: Cell. 1996 Nov 1;87(3):543-52
references.pmid: 8898206
references.citation: BMJ. 1993 Jul 31;307(6899):289-92
references.pmid: 8374374
references.citation: Neurology. 2004 Feb 24;62(4):563-8
references.pmid: 14981171
references.citation: N Engl J Med. 2005 Mar 31;352(13):1293-304
references.pmid: 15753114
references.citation: Cephalalgia. 2001 Mar;21(2):137-9
references.pmid: 11422096
references.citation: J Neurol Neurosurg Psychiatry. 2002 Dec;73(6):747-50
references.pmid: 12438482
references.citation: Neurology. 2004 Apr 27;62(8):1399-401
references.pmid: 15111681
references.citation: Lancet. 1996 Jun 1;347(9014):1503-6
references.pmid: 8684100
references.citation: Headache. 2003 Feb;43(2):90-5
references.pmid: 12558760
references.citation: Stroke. 1994 May;25(5):974-9
references.pmid: 8165693
references.citation: Headache. 2004 May;44 Suppl 1:S20-30
references.pmid: 15149490
references.citation: J Clin Epidemiol. 1989;42(8):773-80
references.pmid: 2760669
references.citation: Lancet. 2004 Jan 31;363(9406):381-91
references.pmid: 15070571
references.citation: Arch Neurol. 2004 Aug;61(8):1237-40
references.pmid: 15313840
references.citation: Neuroepidemiology. 1993;12(2):70-81
references.pmid: 8232706
references.citation: Cephalalgia. 1988;8 Suppl 7:1-96
references.pmid: 3048700
references.citation: Cerebrovasc Dis. 1998 Nov-Dec;8(6):327-30
references.pmid: 9774749
references.citation: Cephalalgia. 2005 Aug;25(8):575-80
references.pmid: 16033382
references.citation: Neurology. 2005 Feb 22;64(4):614-20
references.pmid: 15728281
references.citation: JAMA. 2004 Jan 28;291(4):427-34
references.pmid: 14747499
references.citation: Cephalalgia. 2000 Oct;20(8):687-95
references.pmid: 11167896
references.citation: Neurology. 2005 May 10;64(9):1573-7
references.pmid: 15883318