[Assessment of effectiveness of different doses of methylprednisolone on intraabdominal adhesion prevention].
BACKGROUND
To assess the effectiveness of different doses of methylprednisolone on preventing intraabdominal adhesions established experimentally in rats.


METHODS
Forty female Wistar rats were divided into four groups: high-dose steroid (16 mg/kg), low-dose steroid (10 mg/kg), serum physiologic, and control. Following median laparotomy and procedure for adhesion formation in all rats, 16 mg/kg methylprednisolone (high-dose steroid group), 10 mg/kg methylprednisolone (low-dose steroid group), or serum physiologic (serum physiologic group) was administered into the intraperitoneal space, topically. No additional procedure was applied to rats in Group 4 (Control). All rats were sacrificed on day 15 postoperatively, and intraperitoneal adhesions were assessed according to Linsky's scale.


RESULTS
No significant differences were determined between the groups with respect to severity (p=0.867), degree (p=0.919), extent (p=0.876), and general scores (p=0.574) of adhesion formation. Wound infection rates were also similar in the four groups (p>0.05).


CONCLUSIONS
There was no difference in the effectiveness of different methylprednisolone doses, administered topically, in preventing intraabdominal adhesion formation, and furthermore, steroids do not prevent intraabdominal adhesion development.
Kirdak
Turkay
T
Department Of Surgery, Uludag University Medical Faculty, Bursa, Turkey. tkirdak@uludag.edu.tr
Uysal
Erdal
E
Korun
Nusret
N
D034861:Abdominal Wall / Q000473:pathology*; D000287:Administration, Topical; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D000267:Tissue Adhesions; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
D005938:Glucocorticoids; D008775:Methylprednisolone