Computational study of growth and remodelling in the aortic arch.
Opening angles (OAs) are associated with growth and remodelling in arteries. One curiosity has been the relatively large OAs found in the aortic arch of some animals. Here, we use computational models to explore the reasons behind this phenomenon. The artery is assumed to contain a smooth muscle/collagen phase and an elastin phase. In the models, growth and remodelling of smooth muscle/collagen depends on wall stress and fluid shear stress. Remodelling of elastin, which normally turns over very slowly, is neglected. The results indicate that OAs generally increase with longitudinal curvature (torus model), earlier elastin production during development, and decreased wall stiffness. Correlating these results with available experimental data suggests that all of these effects may contribute to the large OAs in the aortic arch. The models also suggest that the slow turnover rate of elastin limits longitudinal growth. These results should promote increased understanding of the causes of residual stress in arteries.
Alford
Patrick W
PW
Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA.
Taber
Larry A
LA
D000818:Animals; D001013:Aorta, Thoracic / Q000254:growth & development* / Q000502:physiology; D001783:Blood Flow Velocity; D004548:Elasticity; D004549:Elastin / Q000502:physiology*; D008954:Models, Biological; D009131:Muscle, Smooth, Vascular / Q000502:physiology*; D033081:Shear Strength
D004549:Elastin
Am J Physiol. 1989 Apr;256(4 Pt 2):H931-9
2705563
J Biomech Eng. 1998 Feb;120(1):9-17
9675674
J Appl Physiol (1985). 1991 Jun;70(6):2455-70
1885439
Histochemistry. 1993 Jul;100(1):17-26
8226106
J Gen Physiol. 1977 Apr;69(4):449-61
853286
Am J Physiol Heart Circ Physiol. 2004 Jun;286(6):H2361-8
15148060
J Biomech Eng. 1996 Feb;118(1):62-73
8833076
J Cardiovasc Pharmacol. 1984 Nov-Dec;6(6):1161-9
6084775
J Biomech Eng. 1998 Jun;120(3):348-54
10412402
J Biomech Eng. 2001 Dec;123(6):528-35
11783722
J Biomech Eng. 1986 May;108(2):189-92
3079517
J Biomech Eng. 2004 Jun;126(3):371-81
15341175
J Biomech Eng. 1999 Dec;121(6):591-7
10633258
Biomech Model Mechanobiol. 2007 Sep;6(5):321-31
17119902
Circ Res. 2002 May 3;90(8):918-25
11988494
Circulation. 1993 Nov;88(5 Pt 1):2235-47
8222118
Biomech Model Mechanobiol. 2003 Nov;2(2):109-26
14586812
J Biomech Eng. 1988 Feb;110(1):82-4
3347028
J Biomech Eng. 1998 Feb;120(1):18-21
9675675
Biomech Model Mechanobiol. 2008 Dec;7(6):427-41
17909868
Biorheology. 2001;38(2-3):75-87
11381166
Biochim Biophys Acta. 1980 Jul 15;630(4):519-29
6772235
J Vasc Res. 1995 Nov-Dec;32(6):398-405
8562812
J Biomech. 2005 Jun;38(6):1255-61
15863110
J Theor Biol. 2004 Jan 7;226(1):53-64
14637054
Hypertension. 2007 Jul;50(1):255-60
17485596
J Biomech. 2002 Oct;35(10):1367-77
12231282
Arterioscler Thromb Vasc Biol. 2007 Feb;27(2):346-51
17122449
Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2754-63
17237244
J Biomech. 1994 Apr;27(4):455-67
8188726
J Theor Biol. 2007 May 7;246(1):87-99
17240401
J Biomech. 2007;40(10):2214-21
17174959
J Theor Biol. 2007 Oct 7;248(3):460-70
17631909
Mol Cell Biol. 2006 Mar;26(5):1700-9
16478991
J Biomech Eng. 1997 Nov;119(4):438-44
9407283
J Biomech Eng. 1991 Nov;113(4):446-51
1762442
Biomech Model Mechanobiol. 2008 Aug;7(4):245-62
17786493
Dev Biol. 1986 Nov;118(1):103-11
3770292
J Biomech Eng. 2002 Aug;124(4):378-87
12188204