Development of meloxicam-loaded electrospun polyvinyl alcohol mats as a transdermal therapeutic agent.
This study reports on the use of electrospun polyvinyl alcohol (PVA) nanofiber mats loaded with meloxicam (MX) as a transdermal drug delivery system. The amounts of MX loaded in the base PVA solution (10% w/v solution) were 2.5, 5, 10 and 20% weight, based on the dry weight of PVA (% wt). The average diameters of these fibers ranged from 121-185 nm. In all concentrations of MX loaded in spun PVA fiber mats, an amorphous nanodispersion of MX with PVA was obtained. Both the degree of swelling and the weight loss of the electrospun PVA mats were greater than those of the as-cast PVA films. The tensile strength of the as-spun fiber mats was lower than that of the as-cast PVA films, but the strain at the maximum of the as-spun fiber mats was about six times higher than that of the as-cast PVA films. The skin permeation flux of the MX permeated from MX-loaded as-spun PVA were significantly higher than from MX-loaded as-cast PVA films, and increased when the MX content in both MX-loaded as-spun PVA and MX-loaded as-cast PVA films was increased. Our research suggests a potential use for MX-loaded electrospun PVA mats as a transdermal drug delivery system.
Ngawhirunpat
Tanasait
T
Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand. tanasait@email.pharm.su.ac.th
Opanasopit
Praneet
P
Rojanarata
Theerasak
T
Akkaramongkolporn
Prasert
P
Ruktanonchai
Uracha
U
Supaphol
Pitt
P
D000279:Administration, Cutaneous; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004553:Electric Conductivity; D055664:Electrochemical Techniques / Q000379:methods*; D000077239:Meloxicam; D015394:Molecular Structure; D010539:Permeability; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D012996:Solutions / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*; D013696:Temperature; D013718:Tensile Strength; D013843:Thiazines / Q000737:chemistry* / Q000627:therapeutic use*; D013844:Thiazoles / Q000737:chemistry* / Q000627:therapeutic use*; D014783:Viscosity
D000894:Anti-Inflammatory Agents, Non-Steroidal; D012996:Solutions; D013843:Thiazines; D013844:Thiazoles; D011142:Polyvinyl Alcohol; D000077239:Meloxicam