title: Pharmacodynamic evaluation of oral estradiol nanoparticles in estrogen deficient (ovariectomized) high-fat diet induced hyperlipidemic rat model.
abstract: OBJECTIVE
  It is believed that estrogen deficiency contributes importantly to the pathogenesis of menopausal metabolic syndrome and symptoms can be ameliorated with estradiol therapy. The present study reports efficacy of 17-beta estradiol encapsulated nanoparticles in treating the postmenopausal dyslipidemic condition.
  
  
  METHODS
  Estradiol encapsulated poly(lactide-co-glycolide) (PLGA) nanoparticles were prepared by emulsion-diffusion-evaporation method and evaluated in estrogen deficient (ovariectomized) high fat diet induced hyperlipidemic rat model.
  
  
  RESULTS
  The results obtained showed that estradiol nanoparticles were equally/more effective in treatment of estrogen deficient hyperlipidemic conditions at three times reduced dose and frequency in comparison to that of drug suspension administered orally.
  
  
  CONCLUSIONS
  Together, these results demonstrate the ability of nanoparticles in improving oral bioavailability/efficacy of estradiol.
authors.affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.
authors.forename: G
authors.initials: G
authors.lastname: Mittal
authors.forename: G
authors.initials: G
authors.lastname: Chandraiah
authors.forename: P
authors.initials: P
authors.lastname: Ramarao
authors.forename: M N V
authors.initials: MN
authors.lastname: Ravi Kumar
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood; D004032:Diet; D004041:Dietary Fats / Q000494:pharmacology*; D004958:Estradiol / Q000008:administration & dosage* / Q000494:pharmacology*; D005260:Female; D006949:Hyperlipidemias / Q000378:metabolism*; D019344:Lactic Acid; D053758:Nanoparticles; D010052:Ovariectomy; D010316:Particle Size; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D051381:Rats; D017207:Rats, Sprague-Dawley; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
chemical_list: D004041:Dietary Fats; D017392:Thiobarbituric Acid Reactive Substances; D014280:Triglycerides; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D004958:Estradiol; D002784:Cholesterol
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