title: The different sources of variation in inbreeding depression, heterosis and outbreeding depression in a metapopulation of Physa acuta.
abstract: Understanding how parental distance affects offspring fitness, i.e., the effects of inbreeding and outbreeding in natural populations, is a major goal in evolutionary biology. While inbreeding is often associated with fitness reduction (inbreeding depression), interpopulation outcrossing may have either positive (heterosis) or negative (outbreeding depression) effects. Within a metapopulation, all phenomena may occur with various intensities depending on the focal population (especially its effective size) and the trait studied. However, little is known about interpopulation variation at this scale. We here examine variation in inbreeding depression, heterosis, and outbreeding depression on life-history traits across a full-life cycle, within a metapopulation of the hermaphroditic snail Physa acuta. We show that all three phenomena can co-occur at this scale, although they are not always expressed on the same traits. A large variation in inbreeding depression, heterosis, and outbreeding depression is observed among local populations. We provide evidence that, as expected from theory, small and isolated populations enjoy higher heterosis upon outcrossing than do large, open populations. These results emphasize the need for an integrated theory accounting for the effects of both deleterious mutations and genetic incompatibilities within metapopulations and to take into account the variability of the focal population to understand the genetic consequences of inbreeding and outbreeding at this scale.
authors.affiliation: Centre d'Ecologie Fonctionnelle et Evolutive UMR 5175, 34293 Montpellier, France.
authors.forename: Juan Sebastián
authors.initials: JS
authors.lastname: Escobar
authors.forename: Antoine
authors.initials: A
authors.lastname: Nicot
authors.forename: Patrice
authors.initials: P
authors.lastname: David
mesh_terms: D000818:Animals; D001947:Breeding; D005819:Genetic Markers; D014644:Genetic Variation; D005828:Genetics, Population; D006823:Hybrid Vigor / Q000235:genetics*; D012908:Snails / Q000235:genetics*
chemical_list: D005819:Genetic Markers
references.citation: Genet Res. 1999 Dec;74(3):329-40
references.pmid: 10689809
references.citation: Genetics. 2006 Feb;172(2):1337-47
references.pmid: 16322514
references.citation: Genetics. 1936 Mar;21(2):113-35
references.pmid: 17246786
references.citation: Heredity (Edinb). 2005 Dec;95(6):428-36
references.pmid: 16175196
references.citation: Evolution. 1991 May;45(3):622-629
references.pmid: 28568822
references.citation: Genet Res. 2002 Dec;80(3):197-204
references.pmid: 12688658
references.citation: Evolution. 2000 Apr;54(2):485-91
references.pmid: 10937225
references.citation: Genetica. 2003 Jan;117(1):3-16
references.pmid: 12656568
references.citation: Evolution. 1999 Jun;53(3):758-768
references.pmid: 28565642
references.citation: Evolution. 2002 Jan;56(1):131-42
references.pmid: 11913658
references.citation: Evolution. 2007 Nov;61(11):2655-70
references.pmid: 17894808
references.citation: Mol Ecol. 2007 Feb;16(3):463-75
references.pmid: 17257106
references.citation: Genet Res. 2000 Feb;75(1):75-81
references.pmid: 10740923
references.citation: J Theor Biol. 1966 Sep;12(1):12-45
references.pmid: 6015424
references.citation: Genetics. 1948 Sep;33(5):477-87
references.pmid: 17247292
references.citation: Oecologia. 1995 Sep;104(1):93-100
references.pmid: 28306918
references.citation: Genetics. 1963 Oct;48:1303-12
references.pmid: 14071753
references.citation: Evolution. 2001 Jun;55(6):1085-94
references.pmid: 11475044
references.citation: Heredity (Edinb). 1999 Sep;83 ( Pt 3):337-46
references.pmid: 10504432
references.citation: Genetics. 1931 Mar;16(2):97-159
references.pmid: 17246615
references.citation: Heredity (Edinb). 1999 Sep;83 ( Pt 3):260-70
references.pmid: 10504423
references.citation: Mol Ecol. 2006 May;15(6):1561-76
references.pmid: 16629811
references.citation: Heredity (Edinb). 2000 Mar;84 ( Pt 3):273-82
references.pmid: 10762398
references.citation: Genetics. 2001 Nov;159(3):1217-29
references.pmid: 11729164
references.citation: Mol Ecol. 2007 Jun;16(12):2474-87
references.pmid: 17561907
references.citation: Am J Bot. 1998 May;85(5):644
references.pmid: 21684945
references.citation: Evolution. 1989 Aug;43(5):1097-1109
references.pmid: 28564159
references.citation: Genetics. 2001 Aug;158(4):1737-53
references.pmid: 11514459
references.citation: Genetics. 1997 Apr;145(4):1219-28
references.pmid: 9093870
references.citation: Proc Natl Acad Sci U S A. 1937 Jun;23(6):307-20
references.pmid: 16577780
references.citation: Evolution. 1994 Jun;48(3):842-852
references.pmid: 28568280
references.citation: Evolution. 1994 Oct;48(5):1735-1741
references.pmid: 28568424
references.citation: Evolution. 2005 Jul;59(7):1389-99
references.pmid: 16153025
references.citation: Evolution. 2003 Dec;57(12):2678-87
references.pmid: 14761049
references.citation: Mol Ecol. 2004 Jul;13(7):2023-36
references.pmid: 15189223
references.citation: Evolution. 1990 Nov;44(7):1814-1822
references.pmid: 28567806
references.citation: Genet Res. 1999 Dec;74(3):237-44
references.pmid: 10689801
references.citation: Evolution. 2000 Aug;54(4):1157-72
references.pmid: 11005285
references.citation: Heredity (Edinb). 1999 Aug;83 ( Pt 2):103-9
references.pmid: 10469197
references.citation: Proc Biol Sci. 2007 Sep 22;274(1623):2357-64
references.pmid: 17623641
references.citation: Genetics. 1974 Aug;77(4):771-93
references.pmid: 4213910
references.citation: Evolution. 1999 Dec;53(6):1734-1743
references.pmid: 28565456
references.citation: Evol Bioinform Online. 2007 Feb 23;1:47-50
references.pmid: 19325852
references.citation: Heredity (Edinb). 2001 Aug;87(Pt 2):190-7
references.pmid: 11703509
references.citation: Trends Ecol Evol. 2004 Sep;19(9):489-96
references.pmid: 16701312
references.citation: Am J Bot. 1997 Dec;84(12):1685
references.pmid: 21708572
references.citation: Genet Res. 1999 Dec;74(3):215-21
references.pmid: 10689799
references.citation: Am Nat. 2000 Feb;155(2):154-167
references.pmid: 10686158
references.citation: Genetica. 1998;102-103(1-6):559-67
references.pmid: 9720298
references.citation: Heredity (Edinb). 2000 Apr;84 ( Pt 4):452-7
references.pmid: 10849069
references.citation: Evolution. 1999 Dec;53(6):1757-1768
references.pmid: 28565458
references.citation: Evolution. 1996 Feb;50(1):54-70
references.pmid: 28568860
references.citation: Genetics. 2003 Aug;164(4):1627-33
references.pmid: 12930766
references.citation: Proc Biol Sci. 2005 Jul 7;272(1570):1333-8
references.pmid: 16006327
references.citation: Genetics. 2003 Mar;163(3):955-72
references.pmid: 12663535
references.citation: Am J Bot. 2005 May;92(5):842-51
references.pmid: 21652465
references.citation: Genetics. 1993 Oct;135(2):367-74
references.pmid: 8244001
references.citation: Genetics. 2000 May;155(1):337-48
references.pmid: 10790407