A new family of tunable indolylphosphine ligands by one-pot assembly and their applications in Suzuki-Miyaura coupling of aryl chlorides.
This study describes a new class of indolylphosphine ligands, which can be easily accessed by a simple one-pot assembly from commercially available indoles, acid chlorides, and chlorophosphines. A combination of these three starting materials provides a high diversification of the ligand structure. The application of this ligand array in palladium-catalyzed Suzuki-Miyaura coupling reaction of aryl chlorides with arylboronic acids is described. A catalyst loading down to 0.01 mol % of Pd can be achieved.
So
Chau Ming
CM
Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The Hong Kong Polytechnic University, Kowloon, Hong Kong.
Yeung
Chung Chiu
CC
Lau
Chak Po
CP
Kwong
Fuk Yee
FY
D001897:Boronic Acids; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry; D008024:Ligands; D008722:Methods; D010720:Phosphines / Q000138:chemical synthesis / Q000737:chemistry*
D001897:Boronic Acids; D006843:Hydrocarbons, Chlorinated; D007211:Indoles; D008024:Ligands; D010720:Phosphines