title: Biological properties of trabecular meshwork cells.
abstract: The molecular and physiological mechanisms that lead to the progression of glaucoma are poorly understood. Despite the fact that glaucoma afflicts millions of people worldwide, research on the disease is limited by the current animal models that do not translate well to human forms of the disease. However, recent advances in culturing and manipulating human trabecular meshwork cells may provide a means to elucidate some of the mechanisms that cause glaucoma. This review focuses on the properties of trabecular meshwork cells, from their characteristic expression profile in vivo to their responsiveness to biochemical and biophysical signals in vitro. Hopefully the study of cultured trabecular meshwork cells will provide a better understanding of glaucoma and lead to new, much needed therapies.
authors.affiliation: School of Veterinary Medicine, University of Wisconsin-Madison, Department of Surgical Sciences, Madison, WI 53706, USA.
authors.forename: Joshua Z
authors.initials: JZ
authors.lastname: Gasiorowski
authors.forename: Paul
authors.initials: P
authors.lastname: Russell
mesh_terms: D018929:Cell Culture Techniques; D003907:Dexamethasone / Q000494:pharmacology; D005901:Glaucoma / Q000473:pathology; D005938:Glucocorticoids / Q000494:pharmacology; D006801:Humans; D040542:Mechanotransduction, Cellular / Q000502:physiology; D008954:Models, Biological; D018384:Oxidative Stress / Q000502:physiology; D010587:Phagocytosis; D014129:Trabecular Meshwork / Q000166:cytology* / Q000187:drug effects; D016212:Transforming Growth Factor beta / Q000494:pharmacology
chemical_list: D005938:Glucocorticoids; D016212:Transforming Growth Factor beta; D003907:Dexamethasone
references.citation: Invest Ophthalmol Vis Sci. 1983 Dec;24(12):1541-5
references.pmid: 6581147
references.citation: Curr Eye Res. 2008 Jan;33(1):59-72
references.pmid: 18214743
references.citation: Exp Eye Res. 2004 Nov;79(5):649-63
references.pmid: 15500824
references.citation: Invest Ophthalmol Vis Sci. 1994 Jan;35(1):281-94
references.pmid: 8300356
references.citation: Curr Eye Res. 1984 Jun;3(6):783-94
references.pmid: 6734259
references.citation: Exp Eye Res. 1982 Dec;35(6):611-24
references.pmid: 6185354
references.citation: Invest Ophthalmol Vis Sci. 2008 May;49(5):1916-23
references.pmid: 18223246
references.citation: J Biol Chem. 2008 Jan 4;283(1):603-612
references.pmid: 17984096
references.citation: Eye (Lond). 2000 Jun;14 ( Pt 3B):503-14
references.pmid: 11026980
references.citation: Invest Ophthalmol Vis Sci. 1997 Aug;38(9):1902-7
references.pmid: 9286282
references.citation: Invest Ophthalmol Vis Sci. 1999 Sep;40(10):2235-41
references.pmid: 10476788
references.citation: Prog Retin Eye Res. 1999 Sep;18(5):629-67
references.pmid: 10438153
references.citation: Invest Ophthalmol Vis Sci. 1998 Aug;39(9):1575-89
references.pmid: 9699547
references.citation: Invest Ophthalmol Vis Sci. 1990 Jul;31(7):1327-31
references.pmid: 2365563
references.citation: J Glaucoma. 2000 Dec;9(6):468-79
references.pmid: 11131754
references.citation: Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2495-505
references.pmid: 18515587
references.citation: Invest Ophthalmol Vis Sci. 1979 Oct;18(10):1043-9
references.pmid: 383640
references.citation: Invest Ophthalmol Vis Sci. 1995 Apr;36(5):787-95
references.pmid: 7706026
references.citation: Exp Eye Res. 2007 Mar;84(3):435-43
references.pmid: 17173894
references.citation: Invest Ophthalmol Vis Sci. 1990 Oct;31(10):2156-63
references.pmid: 2211012
references.citation: Exp Eye Res. 2003 Dec;77(6):749-56
references.pmid: 14609563
references.citation: Invest Ophthalmol Vis Sci. 2003 Dec;44(12):5301-8
references.pmid: 14638730
references.citation: Invest Ophthalmol Vis Sci. 2001 Jun;42(7):1505-13
references.pmid: 11381054
references.citation: J Cell Physiol. 2004 Jul;200(1):45-52
references.pmid: 15137056
references.citation: Exp Eye Res. 1988 Jun;46(6):881-95
references.pmid: 3197758
references.citation: J Glaucoma. 1997 Aug;6(4):246-9
references.pmid: 9264304
references.citation: Jpn J Ophthalmol. 1989;33(1):95-102
references.pmid: 2659860
references.citation: Am J Ophthalmol. 1971 Jan;71(1 Pt 2):366-85
references.pmid: 5542135
references.citation: Ophthalmology. 1984 Jun;91(6):580-95
references.pmid: 6540429
references.citation: Invest Ophthalmol Vis Sci. 1996 Nov;37(12):2402-13
references.pmid: 8933757
references.citation: Mol Vis. 2007 Aug 01;13:1363-74
references.pmid: 17768383
references.citation: Tissue Eng. 2006 Feb;12(2):413-21
references.pmid: 16548699
references.citation: Invest Ophthalmol Vis Sci. 2007 Mar;48(3):1164-72
references.pmid: 17325160
references.citation: Invest Ophthalmol Vis Sci. 2007 Feb;48(2):715-26
references.pmid: 17251470
references.citation: Invest Ophthalmol Vis Sci. 1987 Jun;28(6):945-53
references.pmid: 3583633
references.citation: Am J Ophthalmol. 2008 Jan;145(1):114-9
references.pmid: 17988642
references.citation: Nat Med. 2001 Mar;7(3):304-9
references.pmid: 11231628
references.citation: Invest Ophthalmol Vis Sci. 2003 Dec;44(12):5174-81
references.pmid: 14638714
references.citation: Curr Eye Res. 1991 Dec;10(12):1101-12
references.pmid: 1802612
references.citation: Invest Ophthalmol Vis Sci. 2008 Jan;49(1):262-9
references.pmid: 18172101
references.citation: Invest Ophthalmol Vis Sci. 1993 Jun;34(7):2228-36
references.pmid: 8505204
references.citation: J Biomed Mater Res A. 2006 Oct;79(1):185-92
references.pmid: 16817223
references.citation: Exp Eye Res. 1994 Dec;59(6):723-7
references.pmid: 7698265
references.citation: Invest Ophthalmol Vis Sci. 2000 Jul;41(8):2229-38
references.pmid: 10892867
references.citation: Curr Eye Res. 2000 May;20(5):347-50
references.pmid: 10855028
references.citation: Mol Vis. 2002 Jul 15;8:241-50
references.pmid: 12131877
references.citation: Acta Ophthalmol Scand. 2005 Feb;83(1):104-8
references.pmid: 15715567
references.citation: J Biomed Mater Res A. 2005 Dec 1;75(3):603-11
references.pmid: 16106433
references.citation: Invest Ophthalmol Vis Sci. 1996 Nov;37(12):2426-33
references.pmid: 8933759
references.citation: Ophthalmology. 1984 Jun;91(6):564-79
references.pmid: 6462622
references.citation: Curr Eye Res. 1989 Nov;8(11):1121-30
references.pmid: 2612200
references.citation: Invest Ophthalmol Vis Sci. 2005 Aug;46(8):2857-68
references.pmid: 16043860
references.citation: Curr Eye Res. 1995 Dec;14(12):1095-1100
references.pmid: 8974838
references.citation: Mol Vis. 2007 Dec 17;13:2282-8
references.pmid: 18199969
references.citation: Invest Ophthalmol Vis Sci. 2003 Nov;44(11):4796-804
references.pmid: 14578401
references.citation: Exp Eye Res. 2007 Feb;84(2):275-84
references.pmid: 17126833
references.citation: Biochem Biophys Res Commun. 2003 Aug 22;308(2):346-52
references.pmid: 12901875
references.citation: J Clin Invest. 1993 Apr;91(4):1367-73
references.pmid: 7682570
references.citation: Exp Cell Res. 2005 Feb 15;303(2):218-28
references.pmid: 15652337
references.citation: Invest Ophthalmol Vis Sci. 2008 Feb;49(2):629-35
references.pmid: 18235008