title: Variability in initial nicotine sensitivity due to sex, history of other drug use, and parental smoking.
abstract: Initial sensitivity to nicotine's effects during early exposure to tobacco may relate to dependence vulnerability. We examined the association of initial nicotine sensitivity with individual difference factors of sex, other drug use history (i.e. cross-tolerance or cross-sensitization), and parental smoking status in young adult nonsmokers (N=131). Participants engaged in 4 sessions, the first 3 to assess the dose-response effects of nasal spray nicotine (0, 5, 10 microg/kg) on rewarding, mood, physiological, sensory processing, and performance effects, and the fourth to assess nicotine reinforcement using a choice procedure. Men had greater initial sensitivity than women to some self-reported effects of nicotine related to reward and incentive salience and to impairment in sensory processing, but men and women did not differ on most other effects. Prior marijuana use was associated with greater nicotine reward, nicotine reinforcement was greater in men versus women among those with prior marijuana use, and having parents who smoked was related to increased incentive salience. However, history of other drug use and parental smoking were not otherwise associated with initial nicotine sensitivity. These findings warrant replication with other methods of nicotine administration, especially cigarette smoking, and in more diverse samples of subjects naïve to nicotine. Yet, they suggest that sex differences in initial sensitivity to nicotine reward occur before the onset of dependence. They also suggest that parental smoking may not increase risk of nicotine dependence in offspring by altering initial nicotine sensitivity, and that cross-tolerance between other drugs and nicotine may not be robust in humans.
authors.affiliation: Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA 15213, USA. perkinska@upmc.edu
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Perkins
authors.forename: Sarah B
authors.initials: SB
authors.lastname: Coddington
authors.forename: Joshua L
authors.initials: JL
authors.lastname: Karelitz
authors.forename: Christopher
authors.initials: C
authors.lastname: Jetton
authors.forename: John A
authors.initials: JA
authors.lastname: Scott
authors.forename: Annette S
authors.initials: AS
authors.lastname: Wilson
authors.forename: Caryn
authors.initials: C
authors.lastname: Lerman
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D000339:Affect / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D003215:Conditioning, Eyelid / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D004493:Education; D005006:Ethnicity; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D017533:Marital Status; D009538:Nicotine / Q000008:administration & dosage / Q000494:pharmacology*; D018722:Nicotinic Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D010290:Parents; D011597:Psychomotor Performance / Q000187:drug effects; D012201:Reward; D018570:Risk Assessment; D012737:Sex Factors; D012907:Smoking / Q000453:epidemiology*; D012959:Socioeconomic Factors; D019966:Substance-Related Disorders / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D018722:Nicotinic Agonists; D009538:Nicotine
references.citation: Nicotine Tob Res. 2007 Sep;9(9):915-26
references.pmid: 17763107
references.citation: Prev Med. 2007 Jun;44(6):485-9
references.pmid: 17363048
references.citation: J Pers Soc Psychol. 1988 Jun;54(6):1063-70
references.pmid: 3397865
references.citation: Exp Clin Psychopharmacol. 2001 Aug;9(3):243-50
references.pmid: 11534534
references.citation: Addict Biol. 1996;1(2):133-41
references.pmid: 12893473
references.citation: Addict Behav. 2005 Mar;30(3):437-41
references.pmid: 15718061
references.citation: Addict Biol. 1998 Oct;3(4):383-404
references.pmid: 26735114
references.citation: Psychopharmacology (Berl). 2003 Aug;169(1):10-20
references.pmid: 12721780
references.citation: Nicotine Tob Res. 2005 Oct;7(5):747-59
references.pmid: 16191746
references.citation: Behav Genet. 1995 Mar;25(2):161-77
references.pmid: 7733857
references.citation: Nicotine Tob Res. 2002 Nov;4(4):405-22
references.pmid: 12521400
references.citation: J Chromatogr. 1981 Jan 2;222(1):61-70
references.pmid: 6783675
references.citation: J Pharmacol Exp Ther. 2001 Mar;296(3):849-56
references.pmid: 11181916
references.citation: Am J Public Health. 1997 Mar;87(3):359-64
references.pmid: 9096534
references.citation: J Psychopharmacol. 1992 Jan;6(2):176-90
references.pmid: 22291349
references.citation: J Pharmacol Exp Ther. 1994 Aug;270(2):628-38
references.pmid: 8071855
references.citation: Pharmacol Biochem Behav. 2000 Feb;65(2):247-54
references.pmid: 10672976
references.citation: Exp Clin Psychopharmacol. 1998 May;6(2):209-16
references.pmid: 9608353
references.citation: Nicotine Tob Res. 2005 Jun;7(3):317-33
references.pmid: 16085500
references.citation: Am J Psychiatry. 2003 Nov;160(11):1978-84
references.pmid: 14594744
references.citation: Addiction. 2005 Sep;100(9):1352-7
references.pmid: 16128724
references.citation: CMAJ. 2006 Aug 1;175(3):255-61
references.pmid: 16880445
references.citation: Alcohol. 1994 Mar-Apr;11(2):167-76
references.pmid: 8204204
references.citation: Nicotine Tob Res. 1999 Dec;1(4):301-15
references.pmid: 11072427
references.citation: J Pharmacol Exp Ther. 1991 Oct;259(1):392-402
references.pmid: 1920127
references.citation: Drug Alcohol Depend. 2007 May 11;88(2-3):251-8
references.pmid: 17129681
references.citation: Alcohol Clin Exp Res. 1991 Feb;15(1):94-101
references.pmid: 2024739
references.citation: Addict Behav. 2004 Dec;29(9):1851-5
references.pmid: 15530728
references.citation: Psychopharmacology (Berl). 2000 Jun;150(3):244-52
references.pmid: 10923751
references.citation: Alcohol Clin Exp Res. 1995 Oct;19(5):1111-20
references.pmid: 8561278
references.citation: Addiction. 2005 Oct;100(10):1518-25
references.pmid: 16185213
references.citation: Addiction. 2004 Aug;99(8):1049-61
references.pmid: 15265102
references.citation: Prev Med. 2006 Aug;43(2):125-8
references.pmid: 16697036
references.citation: Eur J Pharmacol. 1995 Jun 6;279(1):59-64
references.pmid: 7556383
references.citation: Am J Public Health. 2006 Feb;96(2):299-308
references.pmid: 16380569
references.citation: Psychopharmacology (Berl). 1997 Jun;131(4):361-70
references.pmid: 9226738
references.citation: Exp Clin Psychopharmacol. 2000 Nov;8(4):462-71
references.pmid: 11127418
references.citation: Psychopharmacology (Berl). 2006 Oct;188(3):355-63
references.pmid: 16960700
references.citation: Biol Psychol. 1998 Jan;47(1):1-43
references.pmid: 9505132
references.citation: Am J Psychiatry. 1992 Nov;149(11):1534-8
references.pmid: 1415821
references.citation: Drug Alcohol Depend. 2000 May 1;59 Suppl 1:S41-60
references.pmid: 10773437
references.citation: Psychopharmacology (Berl). 2005 Jul;180(2):306-15
references.pmid: 15719224
references.citation: Nicotine Tob Res. 2004 Oct;6(5):765-7; discussion 865-7
references.pmid: 15700911
references.citation: Nat Neurosci. 2005 Nov;8(11):1481-9
references.pmid: 16251991
references.citation: Nicotine Tob Res. 2001 May;3(2):141-50
references.pmid: 11403728
references.citation: Addict Behav. 2006 May;31(5):788-801
references.pmid: 15993005
references.citation: Pharmacol Biochem Behav. 1994 Feb;47(2):295-9
references.pmid: 8146220
references.citation: Oncogene. 2002 Oct 21;21(48):7326-40
references.pmid: 12379876
references.citation: Psychopharmacology (Berl). 2001 Jul;156(2-3):266-72
references.pmid: 11549228
references.citation: J Neurosci. 2006 Feb 8;26(6):1872-9
references.pmid: 16467536
references.citation: Drug Alcohol Depend. 2005 Jul;79(1):83-93
references.pmid: 15943947
references.citation: Neuropharmacology. 1999 Apr;38(4):587-95
references.pmid: 10221762
references.citation: Psychopharmacology (Berl). 1999 Mar;142(4):327-33
references.pmid: 10229056
references.citation: Drug Alcohol Depend. 2008 May 1;95(1-2):107-14
references.pmid: 18325694