title: New biocompatible polypyrrole-based films with good blood compatibility and high electrical conductivity.
abstract: A novel O-butyryl chitosan (OBCS)-grafted polypyrrole (PPy) film was described. The immobilization was accomplished by photocrosslinking the OBCS onto PPy films under ultraviolet light irradiation. The surfaces of OBCS-grafted PPy film were characterized by attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy and electron spectroscopy for chemical analysis (ESCA). The blood compatibility of the OBCS-grafted PPy film was evaluated by platelet-rich plasma (PRP) contacting experiments and protein adsorption experiments in vitro. These results have demonstrated that the surface with immobilized OBCS shows much less platelet adhesive and fibrinogen adsorption compared to the control surface. The bulk conductivity values of PPy films were measured by a modified four-probe method. The composite films have both good blood compatibility and high electrical conductivity that make them suitable for using as potential biomaterials, such as electrically conducting blood vessel and functionally haemocompatible substrate of biosensor used directly in whole blood.
authors.affiliation: College of Chemistry and Environment Science, Nanjing Normal University, Nanjing 210097, China.
authors.forename: Chun
authors.initials: C
authors.lastname: Mao
authors.forename: Aiping
authors.initials: A
authors.lastname: Zhu
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wu
authors.forename: Xiangbai
authors.initials: X
authors.lastname: Chen
authors.forename: Jinheung
authors.initials: J
authors.lastname: Kim
authors.forename: Jian
authors.initials: J
authors.lastname: Shen
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D001769:Blood / Q000276:immunology*; D048271:Chitosan / Q000737:chemistry; D004553:Electric Conductivity; D006648:Histocompatibility / Q000276:immunology*; D006801:Humans; D011108:Polymers / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D001672:Biocompatible Materials; D011108:Polymers; D011758:Pyrroles; C067635:polypyrrole; D048271:Chitosan