5-Fluorouracil: mechanisms of resistance and reversal strategies.
The purpose of this work is to review the published studies on the mechanisms of action and resistance of 5-fluorouracil. The review is divided into three main sections: mechanisms of anti-tumor action, studies of the resistance to the drug, and procedures for the identification of new genes involved in resistance with microarray techniques. The details of the induction and reversal of the drug resistance are also described.
Zhang
Ning
N
Department of Orthopaedics, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, 310009, P.R. China. zhangning98@gmail.com
Yin
Ying
Y
Xu
Sheng-Jie
SJ
Chen
Wei-Shan
WS
D000970:Antineoplastic Agents / Q000494:pharmacology; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D005472:Fluorouracil / Q000494:pharmacology* / Q000627:therapeutic use; D020869:Gene Expression Profiling; D006801:Humans
D000970:Antineoplastic Agents; D005472:Fluorouracil
Cancer Res. 1996 Jun 1;56(11):2602-6
8653704
J Biochem Mol Toxicol. 2006;20(2):88-92
16615077
Cancer Chemother Pharmacol. 2007 Feb;59(2):227-33
16724238
Onkologie. 2007 Sep;30(8-9):421-6
17848813
Anticancer Drugs. 2004 Feb;15(2):85-106
15075664
Biochemistry. 2004 Feb 24;43(7):1972-9
14967037
Oncol Rep. 2007 Oct;18(4):801-9
17786339
Anticancer Res. 2008 Jan-Feb;28(1A):9-14
18383818
Proc Natl Acad Sci U S A. 2004 Jan 20;101(3):793-8
14718668
Invest New Drugs. 2000 Nov;18(4):299-313
11081567
Mol Ther. 2004 May;9(5):666-73
15120327
Cancer Res. 2005 Apr 15;65(8):3162-70
15833846
J Pathol. 2005 Jan;205(2):275-92
15641020
Molecules. 2007 Nov 06;12(11):2450-7
18065949
Nucleic Acids Res. 2007;35(2):550-8
17169984
Biochim Biophys Acta. 2002 Jul 18;1587(2-3):206-14
12084462
Lancet. 2000 Mar 25;355(9209):1041-7
10744089
Gastroenterology. 2004 Dec;127(6):1678-84
15578504
Eur J Cancer Clin Oncol. 1983 Jun;19(6):807-15
6191988
Anticancer Res. 2007 Jul-Aug;27(4B):2241-9
17695509
Mol Pharmacol. 1988 Oct;34(4):480-4
2971872
J Clin Pharm Ther. 2008 Jun;33(3):307-14
18452418
Semin Oncol. 2003 Jun;30(3 Suppl 6):3-9
12802789
Cancer Lett. 2008 Aug 18;267(1):26-36
18420342
J Inorg Biochem. 1989 Dec;37(4):325-39
2628549
Clin Cancer Res. 1995 Jul;1(7):723-30
9816038
J Clin Oncol. 1995 Jul;13(7):1663-70
7602356
J Biol Chem. 1978 May 25;253(10):3563-7
649589
Ann Oncol. 2004 Jul;15(7):1025-32
15205195
Mol Cancer Ther. 2005 May;4(5):855-63
15897250
Cancer Lett. 2008 Sep 28;269(1):101-10
18538471
Biochem J. 2006 Feb 15;394(Pt 1):355-63
16259621
Clin Cancer Res. 1999 Mar;5(3):643-54
10100718
Stem Cells. 1996 Jan;14(1):41-6
8820950
Mol Cancer Ther. 2005 Mar;4(3):451-6
15767554
Cancer Chemother Pharmacol. 2007 May;59(6):839-45
17119966
Nucleic Acids Res. 1991 Nov 25;19(22):6139-44
1956773
World J Gastroenterol. 2007 Dec 14;13(46):6249-53
18069768
J Am Chem Soc. 2005 Feb 2;127(4):1116-7
15669847
Br J Cancer. 2000 Sep;83(6):792-9
10952785
Biomed Pharmacother. 2007 Jul;61(6):347-55
17399942
Int J Cancer. 2003 Aug 10;106(1):66-73
12794758
Bioorg Med Chem Lett. 2008 Apr 15;18(8):2701-8
18362071
Br J Cancer. 1999 Feb;79(3-4):627-30
10027340
Cancer Biol Ther. 2005 Feb;4(2):231-41
15684607
Clin Exp Pharmacol Physiol. 1998 Nov;25(11):887-95
9807659
Cancer Invest. 2006 Apr-May;24(3):235-41
16809149
Int J Oncol. 2004 May;24(5):1279-88
15067352
Cancer Lett. 2007 Mar 8;247(1):40-7
16644108
Yeast. 2007 Oct;24(10):861-70
17640085
Int J Cancer. 2008 Aug 1;123(3):577-85
18498133
Biochem Biophys Res Commun. 2005 Jul 1;332(2):433-40
15896711
Biochemistry. 1987 Dec 29;26(26):8606-13
3126806
Oncol Rep. 2006 May;15(5):1293-8
16596200
Mol Pharmacol. 1985 Jul;28(1):80-5
2991733
Biochem Pharmacol. 1980 Jun 1;29(11):1549-53
6446915
Cancer Res. 1995 Apr 1;55(7):1407-12
7882343
Int J Cancer. 2004 Nov 1;112(2):200-12
15352031
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Sep 1;62(Pt 9):840-3
16946460
Digestion. 2008;77 Suppl 1:13-22
18204257
J Biol Chem. 2002 Sep 20;277(38):35481-8
12089154
Int J Urol. 2004 Nov;11(11):993-1000
15509204
Biochim Biophys Acta. 1977 Dec 23;473(2):73-92
145246
Appl Microbiol Biotechnol. 2007 Feb;74(2):282-9
17216455
Oncology. 2002;62(4):354-62
12138244
Biochem Biophys Res Commun. 2008 Jul 4;371(3):531-5
18452707
Clin Cancer Res. 2005 Feb 1;11(3):1277-86
15709199
RNA. 2008 Apr;14(4):666-74
18314501
World J Gastroenterol. 2004 Jul 1;10(13):1979-83
15222051
Cancer Sci. 2006 Jun;97(6):492-8
16734727
Am J Pathol. 1999 Dec;155(6):1861-7
10595916
Cancer Res. 1954 Feb;14(2):119-23
13126946
Nature. 1999 Sep 2;401(6748):86-90
10485711
Clin Cancer Res. 2005 Jul 15;11(14):5067-8
16033817
Clin Cancer Res. 2000 Nov;6(11):4432-41
11106264
Cancer Res. 2007 Feb 1;67(3):940-5
17283124
Biochemistry. 2006 Jun 20;45(24):7415-28
16768437
Cancer Sci. 2007 Apr;98(4):577-83
17425594
Cancer Biol Ther. 2008 Aug;7(8):1305-12
18497562
Nat Rev Cancer. 2003 May;3(5):330-8
12724731
Mol Cancer. 2006 May 18;5:20
16709241
Cancer Res. 1988 Oct 15;48(20):5894-900
3167844
J Clin Oncol. 1989 Jul;7(7):890-9
2661735
Cancer Res. 1990 Sep 15;50(18):5834-40
1697502
Biochim Biophys Acta. 2002 Jul 18;1587(2-3):194-205
12084461
Pharmacol Ther. 1989;40(3):349-71
2646650
Oncogene. 2006 May 25;25(22):3160-9
16407826
Nat Med. 2001 Oct;7(10):1111-7
11590433
Exp Cell Res. 2003 Aug 15;288(2):403-14
12915131
Semin Cancer Biol. 2005 Aug;15(4):277-89
15914026
J Clin Oncol. 2000 Jan;18(1):136-47
10623704
Cancer Lett. 2004 Oct 8;214(1):19-33
15331170
Clin Cancer Res. 2004 Jun 15;10(12 Pt 1):4176-84
15217955
Cancer Res. 2004 Nov 15;64(22):8167-76
15548681
Biochem Pharmacol. 1989 Jan 15;38(2):335-42
2914018
Clin Cancer Res. 2001 Sep;7(9):2832-9
11555601
Int J Cancer. 2002 Apr 1;98(4):498-504
11920608
Genetics. 2008 May;179(1):323-30
18493057
Br J Cancer. 2007 Oct 8;97(7):919-26
17848948
Pharmacol Ther. 1990;48(3):381-95
1707544
Molecules. 2006 Nov 02;11(11):849-57
18007391
Cell. 2004 Jan 9;116(1):121-37
14718172
Biochem Pharmacol. 1996 May 17;51(10):1293-301
8787544
J Biol Chem. 1987 Jun 15;262(17):8235-41
2954951
Oncogene. 1994 Jun;9(6):1799-805
8183579
Biochem Biophys Res Commun. 2007 Jul 27;359(2):304-10
17537404
Biochem Biophys Res Commun. 2004 Apr 9;316(3):781-9
15033468
FEBS Lett. 2004 Mar 12;561(1-3):207-12
15013779
Mol Cell Biol. 2004 Dec;24(24):10766-76
15572680
Oral Oncol. 2004 Jan;40(1):63-70
14662417
Biochem Pharmacol. 1997 Mar 7;53(5):689-96
9113088