HDL-cholesterol and incidence of breast cancer in the ARIC cohort study.
OBJECTIVE
An association of low plasma HDL-cholesterol with risk of breast cancer has been suggested by multiple studies; the evidence, however, is not conclusive. We examined the possible association of low HDL-cholesterol with incidence of breast cancer using data from the Atherosclerosis Risk in Communities Study (ARIC) cohort, a prospective study of a randomly selected sample of women and men from four U.S. communities.


METHODS
Among 7,575 female members of the ARIC cohort, 359 cases of incident breast cancer were ascertained during the follow-up from 1987 through 2000.


RESULTS
In analysis adjusted for age, race, body mass index, smoking, and reproductive variables, we observed no association of low baseline HDL-cholesterol (<50mg/dL) with incident breast cancer in the total sample (hazard ratio [HR]=1.08 [95% confidence interval (CI), 0.84-1.40]) and a modest association (HR=1.67 [95% CI, 1.06-2.63]) among women who were premenopausal at baseline. No association was observed among women who were postmenopausal at baseline. Removal from analysis of the first 5 years of follow-up did not appreciably change the observed associations.


CONCLUSIONS
Results of our study suggest that low HDL-cholesterol among premenopausal women may be a marker of increased breast cancer risk.
Kucharska-Newton
Anna M
AM
Department of Epidemiology, University of North Carolina at Chapel Hill, NC, USA. Anna_Newton@unc.edu
Rosamond
Wayne D
WD
Mink
Pamela J
PJ
Alberg
Anthony J
AJ
Shahar
Eyal
E
Folsom
Aaron R
AR
D015415:Biomarkers / Q000097:blood; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood*; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D017697:Premenopause; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012680:Sensitivity and Specificity
D015415:Biomarkers; D008076:Cholesterol, HDL
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