title: Sensitivity analysis: from model parameters to system behaviour.
abstract: Sensitivity analysis addresses the manner in which model behaviour depends on model parametrization. Global sensitivity analysis makes use of statistical tools to address system behaviour over a wide range of operating conditions, whereas local sensitivity analysis focuses attention on a specific set of nominal parameter values. This narrow focus allows a complete analytical treatment and straightforward interpretation in the local case. Sensitivity analysis is a valuable tool for model construction and interpretation, and can be applied in medicine and biotechnology to predict the effect of interventions.
authors.affiliation: Department of Applied Mathematics, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1. bingalls@math.uwaterloo.ca
authors.forename: Brian
authors.initials: B
authors.lastname: Ingalls
mesh_terms: D000818:Animals; D006801:Humans; D008954:Models, Biological; D049490:Systems Biology