[Correlation of OX40 gene rs17568A/G polymorphism with acute coronary syndrome in Chinese Han population].
OBJECTIVE
To study the correlation of OX40 Gene rs17568A/G polymorphism with acute coronary syndrome in Chinese Han population.


METHODS
228 ACS patients and 165 matched controls of Chinese Han population were selected to study the OX40 gene rs17568A/G polymorphism with PCR-RFLP method. DNA sequences of enzyme digested products were also analyzed.


RESULTS
All three genotypes, AA, AG and GG, were existed both in ACS patients and control group. OX40 gene rs17568A/G polymorphism frequencies were 29.4% for patients and 26.7% for control group respectively, in which the statistic significance was not observed (P > 0.05). Besides, no significant differences were found for G allele and genotype frequencies in different severity of coronary lesion. But the results demonstrated that the presence of G allele was associated with high density lipoprotein (HDL) cholesterol concentration in either patients or controls.


CONCLUSIONS
OX40 gene rs17568A/G polymorphism was not associated with acute coronary syndrome in Chinese population, however, this polymorphism has some influence on serum HDL-C level in Chinese population.
Chen
Yu-cheng
YC
Division of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China.
Zhang
Li
L
Liu
Rui
R
Li
Xian
X
Qiang
Ou
O
Zeng
Zhi
Z
D054058:Acute Coronary Syndrome / Q000097:blood / Q000208:ethnology / Q000235:genetics*; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D002681:China; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D053262:Receptors, OX40 / Q000235:genetics*
D008076:Cholesterol, HDL; D053262:Receptors, OX40; C505716:TNFRSF4 protein, human