title: Developing drugs for core social and communication impairment in autism.
abstract: There are many challenges to studying drug effects on core social and language impairment in autism. Drugs such as fenfluramine, naltrexone, and secretin do not appear to be efficacious for these core symptoms. Risperidone has led to improvement in some aspects of social relatedness when used to treat irritability in autism. More research is needed on the utility of selective serotonin reuptake inhibitors, cholinergic drugs, glutamatergic drugs, and oxytocin for core autistic symptoms.
authors.affiliation: Department of Psychiatry, Indiana University School of Medicine, 1111 West 10th Street, Indianapolis, IN 46202-4800, USA. dposey@iupui.edu
authors.forename: David J
authors.initials: DJ
authors.lastname: Posey
authors.forename: Craig A
authors.initials: CA
authors.lastname: Erickson
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: McDougle
mesh_terms: D000293:Adolescent; D001321:Autistic Disorder / Q000175:diagnosis / Q000188:drug therapy*; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000175:diagnosis / Q000188:drug therapy*; D003147:Communication Disorders / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D011619:Psychotropic Drugs / Q000009:adverse effects / Q000627:therapeutic use*; D012106:Research; D012919:Social Behavior; D016896:Treatment Outcome
chemical_list: D011619:Psychotropic Drugs
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