Carbocyclic L-nucleoside analogs as potential antiviral agents.
The syntheses of several carbocyclic L-nucleoside analogs starting from enantiomerically pure (1R,2S)-2-benzyloxymethylcyclopent-3-enol are described. The key step is the coupling of a protected nucleobase with different cyclopentane derivatives following a modified Mitsunobu protocol.
Jessel
Soenke
S
Organic Chemistry, Department of Chemistry, Faculty of Science, University of Hamburg, Martin-Luther-King-Platz 6, D-20146 Hamburg, Germany.
Meier
Chris
C
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry; D003517:Cyclopentanes / Q000138:chemical synthesis / Q000737:chemistry; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry
D000998:Antiviral Agents; D003517:Cyclopentanes; D009705:Nucleosides