Calcium pre-rinse greatly increases overnight salivary fluoride after a 228 ppm fluoride rinse.
BACKGROUND
Large increases in salivary fluoride were reported 1 h after a calcium pre-rinse/NaF rinse.


OBJECTIVE
This study examined the persistence of these increases.


METHODS
12 subjects rinsed in the evening with water, with a 228 microg/g (ppm) F rinse or with 150 mmol/l calcium lactate followed by a 228 microg/g F rinse. In a second experiment these same patients rinsed with a 912 microg/g F rinse. Saliva samples were obtained the morning after rinsing, centrifuged and the supernatants analyzed.


RESULTS
The Ca pre-rinse/228 microg/g F rinse induced an increase in overnight salivary F over the 912 microg/g F rinse (approximately 2.5 times) and a statistically significant increase over the 228 mug/g F rinse (approximately 5.5 times).


CONCLUSIONS
The results suggest that a Ca pretreatment may increase the cariostatic effect of topical F agents.
Vogel
G L
GL
American Dental Association Foundation, Paffenbarger Research Center, Gaithersburg, MD 20899-8546, USA. jvogel@nist.gov
Chow
L C
LC
Carey
C M
CM
D000328:Adult; D000368:Aged; D017610:Calcium Compounds / Q000627:therapeutic use*; D002327:Cariostatic Agents / Q000032:analysis / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005260:Female; D005459:Fluorides / Q000032:analysis / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006801:Humans; D007773:Lactates / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes / Q000627:therapeutic use*; D012463:Saliva / Q000737:chemistry / Q000378:metabolism*; D012636:Secretory Rate / Q000502:physiology; D013997:Time Factors; D014867:Water; D055815:Young Adult
D017610:Calcium Compounds; D002327:Cariostatic Agents; D007773:Lactates; D009067:Mouthwashes; D014867:Water; C110051:calcium lactate; D005459:Fluorides
J Dent Res. 1997 Mar;76(3):761-7
9109825
J Dent Res. 1990 Feb;69 Spec No:606-13; discussion 634-6
2179321
Caries Res. 1996;30(6):458-64
8946096
J Dent Res. 1990 Feb;69 Spec No:780-5; discussion 820-3
2179341
J Dent Res. 1990 Feb;69 Spec No:522-8; discussion 556-7
2312891
J Dent Res. 2008 May;87(5):466-9
18434578
J Dent Res. 1992 Sep;71(9):1546-52
1522285
J Dent Res. 1992 Apr;71 Spec No:819-21
1592966
J Dent Res. 1992 Mar;71(3):448-52
1573075
Caries Res. 2004 Nov-Dec;38(6):542-50
15528909
J Dent Res. 1990 Feb;69 Spec No:601-5; discussion 634-6
2179320
Arch Oral Biol. 2007 Feb;52(2):110-20
17049334
Caries Res. 2006;40(2):178-80
16508278
Am J Dent. 2003 Oct;16(5):305-12
14677608
J Dent Res. 1990 Feb;69 Spec No:614-9; discussion 634-6
2179322
Caries Res. 2002 Mar-Apr;36(2):136-41
12037371
Caries Res. 1992;26(1):56-8
1568238
J Clin Periodontol. 1996 Dec;23(12):1084-92
8997652
J Am Dent Assoc. 2000 Jul;131(7):887-99
10916327
Caries Res. 2006;40(5):449-54
16946616
J Clin Dent. 2001;12(3):57-62
11505961
Eur J Oral Sci. 2006 Dec;114(6):489-93
17184230
J Dent Res. 2000 Apr;79(4):991-5
10831103
Am J Dent. 2003 Dec;16(6):369-74
15002949