Base-modified ribonucleosides as potential anti-hepatitis C virus agents.
Four novel series of base modified ribonucleoside analogues were synthesized and evaluated as potential anti-HCV agents. For two compounds notable anti-HCV activity was observed The triphosphates of bicyclic pyrimidine ribonucleosides were studied as substrates/inhibitors of HCV RNA-dependent RNA polymerase (RdRp, NS5B protein) and RNA helicase/NTPase (NS3 protein).
Ivanov
A V
AV
Engelhardt Institute of Molecular Biology RAS, 119991 Moscow, Russia.
Smirnova
O A
OA
Golubeva
N A
NA
Ivanov
M A
MA
Tunitskaya
V L
VL
Shipitsyn
A V
AV
Alexandrova
L A
LA
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D016174:Hepacivirus / Q000187:drug effects* / Q000201:enzymology; D020365:RNA Helicases / Q000378:metabolism; D012324:RNA-Dependent RNA Polymerase / Q000378:metabolism; D012263:Ribonucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012265:Ribonucleotides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D017361:Viral Nonstructural Proteins / Q000378:metabolism; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases
D000998:Antiviral Agents; D020365:RNA Helicases; D012324:RNA-Dependent RNA Polymerase; D012263:Ribonucleosides; D012265:Ribonucleotides; D017361:Viral Nonstructural Proteins; C084422:NS3 protein, hepatitis C virus; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases; C087036:NS-5 protein, hepatitis C virus