Silver-promoted domino Pd-catalyzed amination/direct arylation: access to polycyclic heteroaromatics.
Novel tetracyclic and pentacyclic indole derivatives can be prepared from readily available gem-dibromovinyl substrates in a single step by means of an efficient Pd-catalyzed domino Buchwald-Hartwig amination/direct arylation reaction. Enhanced reactivity and selectivity are obtained by the addition of silver salts.
Bryan
Christopher S
CS
Davenport Laboratories, Department of Chemistry, University of Toronto, Toronto, Ontario, Canada M5S.
Lautens
Mark
M
D000586:Amination; D002384:Catalysis; D007211:Indoles / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D011083:Polycyclic Compounds / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*
D007211:Indoles; D011083:Polycyclic Compounds; D012834:Silver; D010165:Palladium