Burn-induced oxidative stress is altered by a low zinc status: kinetic study in burned rats fed a low zinc diet.
As an initial subdeficient status of zinc, considered as an essential antioxidant trace element, is frequent in burned patients, we aim to assess the effects of low zinc dietary intakes on burn-induced oxidative stress, in an animal model. After 8 weeks of conditioning diets containing 80 ppm (control group) or 10 ppm of zinc (depleted group), Wistar rats were 20% TBSA burned and sampled 1-10 days after injury. Kinetic evolutions of zinc status, plasma oxidative stress parameters, and antioxidant enzymes were also studied in blood and organs. The zinc-depleted diet induced, before injury, a significant decrease in zinc bone level and the increase of oxidative stress markers without stimulation of antioxidant enzyme activity. After burn, more markedly in zinc depleted animals than in controls, zinc levels decreased in plasma and bone, while increasing in liver. The decrease of thiol groups and GSH/GSSG ratio and the depression of GPx activity in liver are also moderately emphasized. Nevertheless, depleted zinc status could not be considered as determining for oxidative damages after burn injury. Further investigations must also be done to enlighten the mechanism of beneficial effects of zinc supplementation reported in burned patients.
Claeyssen
Richard
R
Centre de Recherches du Service de Santé des Armées, 24 Avenue des Maquis du Grésivaudan, BP87, 38702 La Tronche cedex, France.
Andriollo-Sanchez
Maud
M
Arnaud
Josiane
J
Touvard
Laurence
L
Alonso
Antonia
A
Chancerelle
Yves
Y
Roussel
Anne-Marie
AM
Agay
Diane
D
D000821:Animal Feed; D000818:Animals; D002056:Burns / Q000378:metabolism / Q000503:physiopathology*; D004032:Diet; D019587:Dietary Supplements; D005942:Gluconates / Q000008:administration & dosage* / Q000494:pharmacology*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014018:Tissue Distribution
D005942:Gluconates; D017392:Thiobarbituric Acid Reactive Substances; C030691:gluconic acid
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