Prenatal and perinatal risk factors for neuroblastoma.
Neuroblastoma is a rare embryonal tumor of childhood for which risk factors are not well known. Using a nested case-control design, we investigated prenatal, perinatal and neonatal risk factors in detail by linking 245 pediatric neuroblastoma cases identified in the Swedish Cancer Register diagnosed in the year 1973-1995 with the Swedish Medical Birth Register. Five living controls per case were randomly selected from the birth registry, matched by gender and age. Increased risks were associated with maternal anemia during pregnancy (odds ratio (OR) = 2.95, 95% confidence interval (CI): 1.53, 5.69), neonatal respiratory distress (OR = 3.61, 95% CI: 1.41, 9.24) and low (below or equal to 7) 1-min Apgar score (OR = 2.23, 95% CI: 1.41, 3.52). Increased risks were limited to cases diagnosed before 1 year of age. Markers of prenatal, perinatal and neonatal distress may be associated with neuroblastoma in infancy, but not with diagnoses at 1 year or above.
Bluhm
Elizabeth
E
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA. elizabeth.c.bluhm@medstar.net
McNeil
Dawn Elizabeth
DE
Cnattingius
Sven
S
Gridley
Gloria
G
El Ghormli
Laure
L
Fraumeni
Joseph F
JF
D000328:Adult; D000740:Anemia / Q000453:epidemiology*; D001034:Apgar Score; D016022:Case-Control Studies; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008498:Medical Record Linkage; D009447:Neuroblastoma / Q000453:epidemiology* / Q000209:etiology*; D016017:Odds Ratio; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology*; D011446:Prospective Studies; D012042:Registries; D012131:Respiratory Insufficiency / Q000150:complications / Q000453:epidemiology*; D018570:Risk Assessment; D012307:Risk Factors; D016019:Survival Analysis; D015996:Survival Rate; D013548:Sweden / Q000453:epidemiology; D055815:Young Adult
Cancer Causes Control. 1996 Jul;7(4):437-48
8813432
Curr Res Anesth Analg. 1953 Jul-Aug;32(4):260-7
13083014
Am J Hum Genet. 1997 Mar;60(3):474-85
9042906
Pediatr Blood Cancer. 2005 Oct 15;45(5):649-55
15547919
Br J Cancer. 1991 Jun;63(6):993-9
2069856
J Natl Cancer Inst. 1987 May;78(5):797-804
3471992
Am J Epidemiol. 2004 Apr 15;159(8):721-31
15051581
Am J Epidemiol. 1996 May 15;143(10):996-1001
8629618
Am J Epidemiol. 2001 Jul 15;154(2):106-14
11447042
Nat Rev Cancer. 2003 Mar;3(3):203-16
12612655
N Engl J Med. 1993 Aug 19;329(8):536-41
8336753
Oncology. 1985;42(6):358-63
2999670
Paediatr Perinat Epidemiol. 2001 Oct;15(4):328-37
11703680
Epidemiology. 2002 Sep;13(5):575-80
12192228
Paediatr Perinat Epidemiol. 2001 Jan;15(1):47-53
11237115
Am J Clin Nutr. 2005 May;81(5):1218S-1222S
15883455
Cancer. 1988 Jun 1;61(11):2202-6
3365650
Proc Natl Acad Sci U S A. 2002 May 14;99(10):7021-6
12011461
J Natl Cancer Inst. 1985 Apr;74(4):789-92
3857376
J Natl Cancer Inst. 1995 Jun 21;87(12):908-14
7666480
Am J Epidemiol. 2007 Mar 1;165(5):486-95
17164463
Clin Pharmacol Ther. 2007 May;81(5):685-91
17314929
Ann N Y Acad Sci. 2000;900:125-36
10818399
Nat Med. 2004 Aug;10(8):789-99
15286780
J Pediatr. 2004 Apr;144(4):444-8
15069390
Med Pediatr Oncol. 1997 Oct;29(4):272-9
9251733
Acta Paediatr Scand. 1984 Jan;73(1):69-74
6702453
Epidemiol Rev. 2002;24(2):91-101
12762085
Int J Cancer. 1996 Mar 15;65(6):774-7
8631590
Epidemiol Rev. 1993;15(2):414-43
8174665
J Clin Epidemiol. 2001 Jul;54(7):702-9
11438411
Am J Epidemiol. 1985 Jun;121(6):924-9
4014183
N Engl J Med. 2005 Nov 24;353(21):2243-53
16306521
Cancer. 2007 Mar 1;109(5):983-92
17285600
Am J Dis Child. 1968 Feb;115(2):253-61
5636501
Cancer Biol Ther. 2004 Jan;3(1):29-35
14726713
Top Magn Reson Imaging. 2006 Apr;17(2):127-36
17198229
Med Pediatr Oncol. 1991;19(2):115-21
1849220
Eur J Pediatr. 2007 May;166(5):433-41
17345098
Cancer Causes Control. 2002 Jun;13(5):401-5
12146844
Scand J Soc Med. 1990 Jun;18(2):143-8
2367825
Am J Epidemiol. 1993 Mar 15;137(6):629-38
8470664
Pediatr Res. 1969 Sep;3(5):389-97
4310035
Cancer Epidemiol Biomarkers Prev. 1995 Jul-Aug;4(5):441-5
7549797
Cancer Cell. 2006 Nov;10(5):413-23
17097563
Clin Pharmacol Ther. 2003 Sep;74(3):288-94
12966372
J Clin Oncol. 2002 Mar 1;20(5):1209-14
11870162