[Study on the value of Helieobacter pylori (H. pylori) stool antigen immunocard STAT in the diagnosis of H. pylori infection: a meta-analysis].
OBJECTIVE
To evaluate the accuracy of the Helicobacter pylori (H. pylori) stool antigen (HpSA) test and ImmunoCard STAT HpSA in the primary diagnosis of H. pylori infection.


METHODS
We searched Medline (1966-2007.4), EMbase (1985-2007.4), Chinese Journals Full-text Database (CJFD) (1994-2007) etc. to identify Clinical Trials of ImmunoCard STAT HpSA for the primary diagnosis of H. pylori infection. Meta-analysis was conducted using the method recommended by The Cochrane Collaboration Center.


RESULTS
Eleven trials were included with pooled sensitivity, pooled specificity as 0.93 (95% CI: 0.91-0.94), 0.93 (95% CI: 0.90- 0.95), respectively. Pooled positive likelihood ratio and pooled negative likelihood ratio were 12.01 (95% CI: 8.90-16.19), 0.08 (95% CI: 0.07-0.11), respectively with the pooled diagnostic odds ratio as 160.14(95% CI :100.43-255.34). The area under the summary receiver operating characteristic (SROC) was 0.974 +/- 0.005.


CONCLUSIONS
ImmunoCard STAT HpSA appeared to be an accurate non-invasive method for the initial diagnosis of H. pylori infection.
Hong
Wan-dong
WD
Department of Gastroenterology, the First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China.
Zhu
Qi-huai
QH
Chen
Xiang-rong
XR
D000942:Antigens, Bacterial / Q000276:immunology*; D005243:Feces / Q000382:microbiology*; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000276:immunology*; D016480:Helicobacter pylori / Q000276:immunology* / Q000302:isolation & purification* / Q000472:pathogenicity; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity
D000942:Antigens, Bacterial; D011933:Reagent Kits, Diagnostic