title: Imaging the pancreas: from ex vivo to non-invasive technology.
abstract: While many recently published reviews have covered non-invasive nuclear imaging techniques, the aim of this review is to focus on current developments in optical imaging technologies for investigating the pancreas. Several of these modalities are being developed into non-invasive, real-time monitoring routines for pancreatic diseases. However, they also provide pre-clinical ex vivo and/or intravital tools for three-dimensional quantitative assessments of cellular and molecular events, with levels of specificity and resolution difficult to achieve with other currently available modalities.
authors.affiliation: Department of Medical Biosciences, Umeå University, S-901 87, Umeå, Sweden.
authors.forename: D
authors.initials: D
authors.lastname: Holmberg
authors.forename: U
authors.initials: U
authors.lastname: Ahlgren
mesh_terms: D000818:Animals; D003952:Diagnostic Imaging / Q000379:methods*; D017930:Genes, Reporter / Q000235:genetics; D006801:Humans; D008164:Luminescent Proteins / Q000235:genetics / Q000378:metabolism; D010182:Pancreatic Diseases / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism
chemical_list: D008164:Luminescent Proteins
references.citation: Nat Med. 2006 Jan;12(1):144-8
references.pmid: 16380717
references.citation: Diabetes. 1989 Jun;38(6):808-14
references.pmid: 2656348
references.citation: Immunol Rev. 2008 Feb;221:200-13
references.pmid: 18275484
references.citation: Science. 1990 Apr 6;248(4951):73-6
references.pmid: 2321027
references.citation: Opt Lett. 2006 Aug 15;31(16):2450-2
references.pmid: 16880852
references.citation: Am J Gastroenterol. 2007 Feb;102(2):269-74
references.pmid: 17100970
references.citation: Nat Methods. 2008 Jul;5(7):609-12
references.pmid: 18516047
references.citation: Mol Ther. 2004 Mar;9(3):428-35
references.pmid: 15006610
references.citation: Curr Med Chem. 2006;13(23):2761-73
references.pmid: 17073627
references.citation: Mol Imaging. 2006 Apr-Jun;5(2):65-75
references.pmid: 16954020
references.citation: J Gastroenterol Hepatol. 2007 Dec;22(12):2256-60
references.pmid: 18031391
references.citation: Development. 2004 Oct;131(19):4665-75
references.pmid: 15329346
references.citation: Transplantation. 2006 May 27;81(10):1421-7
references.pmid: 16732180
references.citation: Nat Methods. 2007 Jan;4(1):31-3
references.pmid: 17143281
references.citation: Mol Imaging. 2007 Nov-Dec;6(6):369-83
references.pmid: 18053408
references.citation: Annu Rev Biomed Eng. 2004;6:209-28
references.pmid: 15255768
references.citation: Mol Imaging. 2004 Oct;3(4):333-42
references.pmid: 15802050
references.citation: Transplantation. 2005 Apr 15;79(7):768-76
references.pmid: 15818318
references.citation: Genes Dev. 2006 Aug 15;20(16):2208-13
references.pmid: 16912273
references.citation: J Mol Med (Berl). 2008 Jan;86(1):5-16
references.pmid: 17665159
references.citation: Science. 2002 Apr 19;296(5567):541-5
references.pmid: 11964482
references.citation: Curr Diab Rep. 2006 Aug;6(4):328-32
references.pmid: 16879787
references.citation: Nat Med. 2008 May;14(5):574-8
references.pmid: 18327249
references.citation: Science. 1991 Nov 22;254(5035):1178-81
references.pmid: 1957169
references.citation: Transplantation. 2004 Apr 27;77(8):1133-7
references.pmid: 15114073
references.citation: Endocr Rev. 2007 Oct;28(6):685-705
references.pmid: 17881611
references.citation: Transplant Proc. 2008 Mar;40(2):444-8
references.pmid: 18374096
references.citation: Genesis. 2005 Oct;43(2):80-6
references.pmid: 16108006
references.citation: Transplantation. 2006 Apr 27;81(8):1185-90
references.pmid: 16641606
references.citation: J Clin Endocrinol Metab. 2007 Dec;92(12):4706-11
references.pmid: 17895314
references.citation: J Clin Invest. 2005 Sep;115(9):2454-61
references.pmid: 16110329
references.citation: Diabetes. 2001 Aug;50(8):1763-70
references.pmid: 11473036
references.citation: Magn Reson Med. 2004 Dec;52(6):1228-33
references.pmid: 15562474
references.citation: Transplantation. 2007 Oct 15;84(7):893-8
references.pmid: 17984843