Transepidermal water loss (TEWL) reflects skin barrier function of dog.
The correlation between skin barrier function and transepidermal water loss (TEWL) was evaluated in dogs. Stratum corneum (SC) of 10 healthy dogs was removed by tape stripping (TS), which decreased the corneal layer to allow for permeation of fluorescent dye into skin. TEWL of damaged skin was measured with the closed-chamber-type TEWL analyzer, CC-01. The frequency of TS was directly related to the decrease of SC and the increased permeation of fluorescent dye, and TEWL increased with increasing impairment of skin barrier function. The results suggest that increased TEWL reflects impaired canine skin barrier function.
Shimada
Kenichiro
K
Department of Veterinary Internal Medicine, Faculty of Agriculture, Tokyo University of Agriculture & Technology, Fuchu, Tokyo, Japan.
Yoshihara
Toru
T
Yamamoto
Masahiko
M
Konno
Katsuhiko
K
Momoi
Yasuyuki
Y
Nishifuji
Koji
K
Iwasaki
Toshiroh
T
D000818:Animals; D004283:Dog Diseases / Q000503:physiopathology; D004285:Dogs / Q000502:physiology*; D004817:Epidermis / Q000502:physiology*; D005260:Female; D005456:Fluorescent Dyes; D008297:Male; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000503:physiopathology / Q000662:veterinary; D012879:Skin Physiological Phenomena; D014870:Water Loss, Insensible / Q000502:physiology*
D005456:Fluorescent Dyes