Serotonin-dopamine interaction: an overview.
Central serotonergic and dopaminergic systems play a critical role in the regulation of normal and abnormal behaviours. Moreover, recent evidence suggests that the dysfunction of dopamine (DA) and serotonin (5-hydroxytriptamine, 5-HT) neurotransmission might underlie the pathophysiology of neuropsychiatric disorders, including depression, schizophrenia, attention deficit hyperactivity disorders, drug abuse, Gilles de la Tourette's syndrome and Parkinson's disease.
Esposito
Ennio
E
Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri, Via Nazionale, 66030 Santa Maria Imbaro, Chieti, Italy. esposito@negrisud.it
Di Matteo
Vincenzo
V
Di Giovanni
Giuseppe
G
D001519:Behavior / Q000502:physiology; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D001523:Mental Disorders / Q000503:physiopathology; D012701:Serotonin / Q000378:metabolism*; D009435:Synaptic Transmission / Q000502:physiology
D012701:Serotonin; D004298:Dopamine