title: Metabolomics-based methods for early disease diagnostics.
abstract: The emerging field of metabolomics, in which a large number of small-molecule metabolites from body fluids or tissues are detected quantitatively in a single step, promises immense potential for early diagnosis, therapy monitoring and for understanding the pathogenesis of many diseases. Metabolomics methods are mostly focused on the information-rich analytical techniques of NMR spectroscopy and mass spectrometry (MS). Analysis of the data from these high-resolution methods using advanced chemometric approaches provides a powerful platform for translational and clinical research and diagnostic applications. In this review, the current trends and recent advances in NMR- and MS-based metabolomics are described with a focus on the development of advanced NMR and MS methods, improved multivariate statistical data analysis and recent applications in the area of cancer, diabetes, inborn errors of metabolism and cardiovascular diseases.
authors.affiliation: Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA. ngowda@purdue.edu
authors.forename: G A Nagana
authors.initials: GA
authors.lastname: Gowda
authors.forename: Shucha
authors.initials: S
authors.lastname: Zhang
authors.forename: Haiwei
authors.initials: H
authors.lastname: Gu
authors.forename: Vincent
authors.initials: V
authors.lastname: Asiago
authors.forename: Narasimhamurthy
authors.initials: N
authors.lastname: Shanaiah
authors.forename: Daniel
authors.initials: D
authors.lastname: Raftery
mesh_terms: D000818:Animals; D004194:Disease; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D055432:Metabolomics / Q000379:methods*; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D013997:Time Factors
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