Wound healing, anti-microbial and antioxidant potential of Dendrophthoe falcata (L.f) Ettingsh.
Dendrophthoe falcata (L.f) Ettingsh (Loranthaceae) of the order Santalales, is used ethnomedicinally for treating ulcers, asthma, impotence, paralysis, skin diseases, and wounds. In this context, validations of the ethnotherapeutic claims of the plant in wound healing activity was studied, besides anti-microbial activity and antioxidant activity were performed to understand the mechanism of wound healing potency. The ethanolic extract of aerial parts of Dendrophthoe falcata ethanolic extract (DFEE) was investigated for the evaluation of its healing efficiency on excision and incision wound models in rats. The results showed that Dendrophthoe falcata extract has potent wound healing capacity as evident from the wound contraction and increased tensile strength. Hydroxyproline and hexosamine expressions were also well correlative with the healing pattern observed. Three of the fractions A-C (petroleum ether, chloroform and ethanol, respectively) obtained from the extract exhibited significant antimicrobial activity against the organisms: Staphylococcus aureus, Staphylococcus pyogenes, Staphylococcus epidermidis, Micrococcus luteus, Bacillus subtilis, Bacillus cereus, Klebsiella pneumoniae, Enterobacter aerogenes, Pseudomonas aeroginosa, Serratia marcescens, and five fungi Candida albicans, Candida tropicalis: dimorphic fungi, Aspergillus fumigatus, Aspergillus niger: systemic fungi, and some infectious bacteria Escherichia coli, and Salmonella typhi. The results also indicated that DFEE possesses potent antioxidant activity by inhibiting lipid peroxidation, reduced glutathione, superoxide dismutase levels and increased the catalase activity.
Pattanayak
S P
SP
Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi 835215, India. shakti.pattanayak@yahoo.co.in
Sunita
P
P
D000818:Animals; D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D004195:Disease Models, Animal; D005260:Female; D005658:Fungi / Q000187:drug effects; D028183:Loranthaceae / Q000737:chemistry*; D008297:Male; D008519:Medicine, Traditional; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013718:Tensile Strength / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects*
D000890:Anti-Infective Agents; D000975:Antioxidants; D010936:Plant Extracts