title: Aggressive combined modality therapy for recurrent colorectal cancer involving the duodenum and pancreas: a report of 5 cases.
abstract: We report 5 cases in which the recurrence of colorectal cancer (CRC) presented as a mass involving the duodenum and pancreas. The treatment approach for such recurrences is not standardized, and in particular, the benefits of pancreaticoduodenectomy for such cases are not known. We describe the successful use of aggressive multimodality treatment with chemotherapy, radiation, and en bloc surgical resection. Such trimodality therapy can result in durable palliation of symptoms and long-term survival for patients with recurrent CRC involving the duodenum and pancreas, even when other metastases are present.
authors.affiliation: Department of Gastrointestinal Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77005, USA. moverman@mdanderson.org
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Overman
authors.forename: David
authors.initials: D
authors.lastname: Fogelman
authors.forename: Aref
authors.initials: A
authors.lastname: Al-Kali
authors.forename: Christopher H
authors.initials: CH
authors.lastname: Crane
authors.forename: Douglas
authors.initials: D
authors.lastname: Evans
authors.forename: Eddie K
authors.initials: EK
authors.lastname: Abdalla
authors.forename: Peter
authors.initials: P
authors.lastname: Pisters
authors.forename: Scott
authors.initials: S
authors.lastname: Kopetz
authors.forename: Cathy
authors.initials: C
authors.lastname: Eng
authors.forename: Robert A
authors.initials: RA
authors.lastname: Wolff
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary / Q000628:therapy*; D000368:Aged; D015179:Colorectal Neoplasms / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D004379:Duodenal Neoplasms / Q000556:secondary / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy*; D010190:Pancreatic Neoplasms / Q000556:secondary / Q000628:therapy*; D019233:Retreatment