[Expression of MMP-2, MMP-9 and collagen type IV and their relationship in colorectal carcinomas].
OBJECTIVE
To investigate the expression of MMP-2, MMP-9 and collagen type IV and their relationship in colorectal carcinomas.


METHODS
The expressions of collagen type IV, MMP-2 and MMP-9 was in normal and colorectal cancer tissues of 30 patients whose clinical stages were Dukes'B and C was detected with immunohistochennical staining. And the relationship among collagen type IV, MMP-2 and MMP-9 was analysed.


RESULTS
The expression of collagen type IV was significantly decreased in colorectal cancer tissues. The expression of MMP-2 and MMP-9 was not detected in normal colorectal tissues but it was significantly increased in colorectal cancer tissues. There was a negative correlation between the expression of collagen type IV and MMP-9.


CONCLUSIONS
The expression of collagen type IV in colorectal cancer tissues is lower than that in normal tissues. MMP-9 may play an important role in the degradation of collagen type IV in colorectal cancer.
Wu
Wei
W
Department of Geriatric Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.
He
Jian-tai
JT
Ruan
Jing-de
JD
Wang
Rong-bing
RB
Zhang
Yang-de
YD
D000328:Adult; D000368:Aged; D024141:Collagen Type IV / Q000235:genetics* / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000235:genetics* / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D009367:Neoplasm Staging
D024141:Collagen Type IV; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9