title: AKT1 (E17K) mutation in pancreatic cancer.
abstract: The prevalence of a novel somatic mutation (E17K) in the pleckstrin homology domain of AKT1 was investigated in pancreatic cancer using a quantitative pyrosequencing assay. This mutation was un-detectable in pancreatic cancer tissue samples (n=65) and pancreatic cell line (n=10) DNA suggesting that pancreatic cancer progression is mainly dependent on the K-Ras mutation.
authors.affiliation: Department of Haematological Medicine, Kings College London, 123 Coldharbour Lane, London.
authors.forename: Azim
authors.initials: A
authors.lastname: Mohamedali
authors.forename: Nicholas C
authors.initials: NC
authors.lastname: Lea
authors.forename: Roger M
authors.initials: RM
authors.lastname: Feakins
authors.forename: Kavita
authors.initials: K
authors.lastname: Raj
authors.forename: Ghulam J
authors.initials: GJ
authors.lastname: Mufti
authors.forename: Hemant M
authors.initials: HM
authors.lastname: Kocher
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D045744:Cell Line, Tumor; D002462:Cell Membrane / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D011905:Genes, ras; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D017434:Protein Structure, Tertiary; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics* / Q000378:metabolism
chemical_list: D019869:Phosphatidylinositol 3-Kinases; C494918:AKT1 protein, human; D051057:Proto-Oncogene Proteins c-akt