title: [Progressive multifocal leukoencephalopathy in the province of Cadiz, Spain].
abstract: BACKGROUND
  Progressive multifocal leukoencephalopathy (PML), which is caused by the reactivation of an infection due to the JC human polyoma virus, affects immunocompromised patients and more especially those infected by the human immunodeficiency virus. It produces a multifocal neurological clinical picture due to the destruction of oligodendrocytes and the subsequent demyelination.
  
  
  OBJECTIVE
  To analyse the epidemiological, semiological and radiological characteristics of a sample of patients diagnosed with PML in the province of Cadiz, and to study their rates of survival.
  
  
  METHODS
  Our sample consisted of 23 patients with PML who presented an unfavourable immunological situation and deficient therapeutic compliance. Factors studied included time to progression of the symptoms, clinical features, neuroimaging and survival.
  
  
  RESULTS
  The mean time elapsed between the appearance of symptoms and diagnosis was 30 days. There was a wide range of manifestations: motor symptoms were the most prevalent and cognitive compromise was far less common. All the patients submitted to magnetic resonance imaging of the head and only eight of those who underwent computerised axial tomography displayed multiple insults. The mean survival time was 60 days in the case of the seven deaths and over two years in those who survived.
  
  
  CONCLUSIONS
  The symptoms of the patients were similar to those reported in the literature, except for the absence of dementia. Magnetic resonance imaging was better than tomography at detecting multiple, dispersed insults and is more cost-effective for diagnosing PML. The survival time of most of the patients was higher than that reported in previous studies.
authors.affiliation: Servicio de Neurología, Hospital Universitario de Puerto Real, Puerto Real, Cádiz, España. mbgg@comcadiz.com
authors.forename: M B
authors.initials: MB
authors.lastname: Gómez-González
authors.forename: J A
authors.initials: JA
authors.lastname: Girón-González
authors.forename: M A
authors.initials: MA
authors.lastname: Rodríguez-Iglesias
authors.forename: M T
authors.initials: MT
authors.lastname: Pérez-Gracia
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology; D000328:Adult; D018450:Disease Progression; D005260:Female; D015658:HIV Infections / Q000473:pathology; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging / Q000191:economics; D008297:Male; D013030:Spain / Q000453:epidemiology; D015996:Survival Rate; D014057:Tomography, X-Ray Computed