title: [Open food challenge with milk, egg white and wheat].
abstract: BACKGROUND
  A method for open food challenge test to determine food allergy has not been established in an evidence-based manner.
  
  
  METHODS
  We conducted an analysis of 438 open food challenges of raw milk (n=133, mean age 2.7+/-1.9 years), boiled egg white (n=216, 2.8+/-2.1 years) or udon noodles (n=89, 2.7+/-1.7 years) for the patients aged 1 year or more. Doses were increased (trace amounts, 1 g, 2 g, 5 g, 10 g, 20-30 g) every 20 minutes.
  
  
  RESULTS
  In total, 151 (38.5%) of food challenges were positive. The positive rates of milk, egg and wheat challenges were 35.8%, 42.4% and 33.3%, respectively. Of these, 76.2%, 32.5%, 27.8% and 0.7% had, respectively, skin, respiratory, gastrointestinal and cardiovascular symptoms. Although the prevalence of positive challenge increased with level of specific IgE, it did not correlate with the threshold amount of positive food challenge or the severity of symptoms. Among the challenge positive patients, 10.6% required injection of antihistamines, corticosteroids or adrenalines for the treatment of the symptoms.
  
  
  CONCLUSIONS
  This challenge protocol seemed to be appropriate and safe.
authors.affiliation: Department of Allergy, Aichi Children's Health and Medical Center. koumei_itoh@mx.achmc.pref.aichi.jp
authors.forename: Komei
authors.initials: K
authors.lastname: Ito
authors.forename: Masaki
authors.initials: M
authors.lastname: Futamura
authors.forename: Yuri
authors.initials: Y
authors.lastname: Takaoka
authors.forename: Masashi
authors.initials: M
authors.lastname: Morishita
authors.forename: Kumiko
authors.initials: K
authors.lastname: Nakanishi
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Sakamoto
mesh_terms: D000818:Animals; D002417:Cattle; D002675:Child, Preschool; D004529:Egg White; D005512:Food Hypersensitivity / Q000175:diagnosis*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007223:Infant; D008892:Milk / Q000276:immunology*; D014908:Triticum / Q000276:immunology*
chemical_list: D007073:Immunoglobulin E