title: Association of cyclooxygenase-2 and interleukin-1 receptor antagonist gene polymorphisms with the time interval between labor induction and delivery.
abstract: OBJECTIVE
  The interval between induction and delivery may change in association with different polymorphisms in genes regulating inflammation.
  
  
  METHODS
  Seventy participants in a trial for induction of labor at term were tested for a -765 G>C cyclooxygenase-2 and an intron 2 length interleukin-1 receptor antagonist gene polymorphism.
  
  
  RESULTS
  The interleukin-1 receptor antagonist allele 2 frequency was 33.3% in the 12 women who delivered at < or =10 hours, compared with 13.8% in those delivered >10 hours (P = .03). The interleukin-1 receptor antagonist allele 2 frequency was 25.0% in women induced because of postdates as opposed to 7.9% induced for other indications (P = .01). The cyclooxygenase-2 allele C frequency was 30.0% in 35 women delivered at < or =20 hours as opposed to 11.4% in women delivered at >20 hours (P = .01). The cyclooxygenase-2 allele C frequency was 26.9% in 26 subjects induced because of postdates as opposed to 13.6% induced for other indications (P = .07).
  
  
  CONCLUSIONS
  Cyclooxygenase-2 allele C and interleukin-1 receptor antagonist allele 2 are associated with a reduced time interval from labor induction to delivery.
authors.affiliation: Department of Obstetrics and Gynecology, New York Hospital Queens, New York, NY, USA.
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Skupski
authors.forename: Neil
authors.initials: N
authors.lastname: Normand
authors.forename: Gary S
authors.initials: GS
authors.lastname: Eglinton
authors.forename: Steven S
authors.initials: SS
authors.lastname: Witkin
mesh_terms: D000328:Adult; D020070:Cervical Ripening / Q000502:physiology*; D051546:Cyclooxygenase 2 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D007751:Labor, Induced; D016104:Oligohydramnios / Q000628:therapy; D011110:Polymorphism, Genetic; D011247:Pregnancy; D013997:Time Factors; D014219:Trial of Labor
chemical_list: D053590:Interleukin 1 Receptor Antagonist Protein; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human