title: Temporal organization of the cell cycle.
abstract: The coordination of growth, DNA replication and division in proliferating cells can be adequately explained by a 'clock + checkpoint' model. The clock is an underlying cyclical sequence of states; the checkpoints ensure that the cycle proceeds without mistakes. From the molecular complexities of the control system in modern eukaryotes, we isolate a simple network of positive and negative feedbacks that embodies a 'clock + checkpoints'. The model accounts for the fundamental physiological properties of mitotic cell divisions, evokes a new view of the meiotic program, and suggests how the control system may have evolved in the first place.
authors.affiliation: Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA. tyson@vt.edu
authors.forename: John J
authors.initials: JJ
authors.lastname: Tyson
authors.forename: Bela
authors.initials: B
authors.lastname: Novak
mesh_terms: D002453:Cell Cycle / Q000502:physiology*; D018844:Cyclin-Dependent Kinases / Q000502:physiology; D005057:Eukaryotic Cells / Q000166:cytology; D008954:Models, Biological
chemical_list: D018844:Cyclin-Dependent Kinases
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