title: Is the blood B-cell subset profile diagnostic for Sjogren syndrome?
abstract: OBJECTIVE
  To evaluate the relevance of the blood B-cell subset profile for the diagnosis of Sjögren syndrome.
  
  
  METHODS
  The distribution of mature blood B cells from Bm1 through Bm5 was determined in 161 patients, of whom 25 fulfilled the American-European Consensus Group criteria for primary SS (pSS), and 136 served as disease controls.
  
  
  RESULTS
  The percentage of Bm2 and Bm2' cells was increased in the patients with pSS compared with 54 patients with rheumatoid arthritis (RA) and 18 with systemic lupus erythematosus (SLE) (p<0.001 for the two comparisons). In contrast, those of early Bm5 (eBm5) and Bm5 were decreased in patients with pSS, compared with patients with RA and with SLE (p<0.001 for the two comparisons). The receiver operating characteristic curves allowed for an optimising cut-off value of Bm2+Bm2' cells at 71.1% for 88.0% sensitivity and 83.1% specificity, that of eBm5+Bm5 cells at < or =13.5% for 84.0% sensitivity and 83.1% specificity, and, consequently, that of Bm2+Bm2'/eBm5+Bm5 at > or =5 for 88.0% sensitivity and 84.6% specificity.
  
  
  CONCLUSIONS
  Given its presentation as a signature for pSS, relative to RA and SLE, such a distribution of B-cell subsets might provide a useful diagnostic tool.
authors.affiliation: EA Immunologie et Pathologie, Université Européenne de Bretagne, et Université de Bretagne Occidentale, Brest, et Centre Hospitalier Universitaire de Brest, Brest F29609, France.
authors.forename: A
authors.initials: A
authors.lastname: Binard
authors.forename: L
authors.initials: L
authors.lastname: Le Pottier
authors.forename: V
authors.initials: V
authors.lastname: Devauchelle-Pensec
authors.forename: A
authors.initials: A
authors.lastname: Saraux
authors.forename: P
authors.initials: P
authors.lastname: Youinou
authors.forename: J-O
authors.initials: JO
authors.lastname: Pers
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000276:immunology; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D003937:Diagnosis, Differential; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012859:Sjogren's Syndrome / Q000175:diagnosis* / Q000276:immunology
chemical_list: D015415:Biomarkers
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