title: Statins alone are ineffective in cerebral malaria but potentiate artesunate.
authors.forename: Anne-Lise
authors.initials: AL
authors.lastname: Bienvenu
authors.forename: Stéphane
authors.initials: S
authors.lastname: Picot
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage*; D037621:Artemisinins / Q000008:administration & dosage*; D000077332:Artesunate; D000069059:Atorvastatin; D004195:Disease Models, Animal; D004357:Drug Synergism; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage; D000077340:Fluvastatin; D006538:Heptanoic Acids / Q000008:administration & dosage; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage*; D007211:Indoles / Q000008:administration & dosage; D016779:Malaria, Cerebral / Q000188:drug therapy* / Q000469:parasitology; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000469:parasitology; D051379:Mice; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D017035:Pravastatin / Q000008:administration & dosage; D011758:Pyrroles / Q000008:administration & dosage; D019821:Simvastatin / Q000008:administration & dosage
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D005229:Fatty Acids, Monounsaturated; D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007211:Indoles; D018696:Neuroprotective Agents; D011758:Pyrroles; D000077340:Fluvastatin; D000077332:Artesunate; D000069059:Atorvastatin; D019821:Simvastatin; D017035:Pravastatin
references.citation: Antimicrob Agents Chemother. 2007 Jul;51(7):2654-5
references.pmid: 17502414
references.citation: J Infect Dis. 2006 Apr 1;193(7):987-95
references.pmid: 16518761
references.citation: Vasc Health Risk Manag. 2007;3(5):611-3
references.pmid: 18078012
references.citation: Circulation. 2005 Jul 5;112(1):117-24
references.pmid: 15998696
references.citation: Stroke. 2005 Jun;36(6):1298-300
references.pmid: 15879346
references.citation: Fundam Clin Pharmacol. 2005 Feb;19(1):117-25
references.pmid: 15660968
references.citation: Lancet Infect Dis. 2007 May;7(5):358-68
references.pmid: 17448939