title: Mammographic density, lobular involution, and risk of breast cancer.
abstract: In this review, we propose that age-related changes in mammographic density and breast tissue involution are closely related phenomena, and consider their potential relevance to the aetiology of breast cancer. We propose that the reduction in mammographic density that occurs with increasing age, parity and menopause reflects the involution of breast tissue. We further propose that age-related changes in both mammographic density and breast tissue composition are observable and measurable phenomena that resemble Pike's theoretical construct of 'breast tissue ageing'. Extensive mammographic density and delayed breast involution are both associated with an increased risk of breast cancer and are consistent with the hypothesis of the Pike model that cumulative exposure of breast tissue to hormones and growth factors that stimulate cell division, as well as the accumulation of genetic damage in breast cells, are major determinants of breast cancer incidence.
authors.affiliation: Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Canada.
authors.forename: O M
authors.initials: OM
authors.lastname: Ginsburg
authors.forename: L J
authors.initials: LJ
authors.lastname: Martin
authors.forename: N F
authors.initials: NF
authors.lastname: Boyd
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000209:etiology*; D005260:Female; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D012307:Risk Factors
references.citation: Cancer Epidemiol Biomarkers Prev. 2004 Dec;13(12):2090-5
references.pmid: 15598766
references.citation: Cancer Res. 2007 Sep 1;67(17):8412-8
references.pmid: 17804758
references.citation: Annu Rev Cell Dev Biol. 2006;22:287-309
references.pmid: 16824016
references.citation: Cancer. 1976 May;37(5):2486-92
references.pmid: 1260729
references.citation: Cancer. 1994 Jul 1;74(1 Suppl):424-9
references.pmid: 8004616
references.citation: Phys Med Biol. 1987 Jun;32(6):675-95
references.pmid: 3039542
references.citation: N Engl J Med. 2007 Jan 18;356(3):227-36
references.pmid: 17229950
references.citation: Cancer Detect Prev. 1992;16(1):67-72
references.pmid: 1532349
references.citation: N Engl J Med. 1985 Jan 17;312(3):146-51
references.pmid: 3965932
references.citation: AJR Am J Roentgenol. 1976 Jun;126(6):1130-7
references.pmid: 179369
references.citation: Nature. 1983 Jun 30;303(5920):767-70
references.pmid: 6866078
references.citation: J Natl Cancer Inst. 1992 Aug 5;84(15):1170-9
references.pmid: 1635085
references.citation: Lancet Oncol. 2005 Oct;6(10):798-808
references.pmid: 16198986
references.citation: J Natl Cancer Inst. 2006 Nov 15;98(22):1600-7
references.pmid: 17105983
references.citation: J Natl Cancer Inst. 2007 Mar 7;99(5):386-95
references.pmid: 17341730
references.citation: J Natl Cancer Inst. 1996 Mar 20;88(6):359-64
references.pmid: 8609645
references.citation: Cancer Epidemiol Biomarkers Prev. 2002 Oct;11(10 Pt 1):1048-53
references.pmid: 12376506
references.citation: Breast Cancer Res. 2008;10(1):201
references.pmid: 18226174
references.citation: Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):732-9
references.pmid: 16614116
references.citation: Cancer. 1987 Dec 1;60(11):2751-60
references.pmid: 3677009
references.citation: Cancer Epidemiol Biomarkers Prev. 1999 Oct;8(10):873-9
references.pmid: 10548315
references.citation: Epidemiol Rev. 1993;15(1):196-208
references.pmid: 8405204
references.citation: Epidemiol Rev. 1987;9:146-74
references.pmid: 3315715
references.citation: Cancer Epidemiol Biomarkers Prev. 2007 May;16(5):921-8
references.pmid: 17507617
references.citation: Cancer Epidemiol Biomarkers Prev. 2006 Jun;15(6):1159-69
references.pmid: 16775176
references.citation: N Engl J Med. 2005 Jul 21;353(3):229-37
references.pmid: 16034008
references.citation: N Engl J Med. 2002 Sep 19;347(12):886-94
references.pmid: 12239257
references.citation: J Natl Cancer Inst. 1995 Nov 1;87(21):1622-9
references.pmid: 7563205
references.citation: Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):612-7
references.pmid: 16614099
references.citation: Cancer Causes Control. 2000 Aug;11(7):653-62
references.pmid: 10977110
references.citation: Curr Opin Genet Dev. 2001 Feb;11(1):54-9
references.pmid: 11163151
references.citation: Cancer Epidemiol Biomarkers Prev. 2005 Feb;14(2):343-9
references.pmid: 15734956