title: A preliminary study of direct application of atelocollagen into a wound lesion in the dog cornea.
abstract: OBJECTIVE
  To evaluate the effectiveness of atelocollagen for canine corneal wound healing.
  
  
  METHODS
  Atelocollagen was used to fill a transplant bed in the central cornea, which was then covered with a contact lens. The wound healing process was analyzed clinically, morphologically, and biochemically.
  
  
  RESULTS
  At the early healing stage, both the pupillary zone and details of the iris were observed. The stromal collagen fibrils normalized in a time-dependent manner. Type III collagen in the wound area was detected faintly throughout the experimental period.
  
  
  CONCLUSIONS
  This novel method is advantageous for accelerating wound healing without causing inflammation.
authors.affiliation: Department of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan.
authors.forename: Aya
authors.initials: A
authors.lastname: Nagayasu
authors.forename: Yoshinao
authors.initials: Y
authors.lastname: Hosaka
authors.forename: Ayako
authors.initials: A
authors.lastname: Yamasaki
authors.forename: Keiko
authors.initials: K
authors.lastname: Tsuzuki
authors.forename: Hiromi
authors.initials: H
authors.lastname: Ueda
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Honda
authors.forename: Kazushige
authors.initials: K
authors.lastname: Takehana
mesh_terms: D000818:Animals; D002452:Cell Count; D003094:Collagen / Q000008:administration & dosage*; D024061:Collagen Type III / Q000378:metabolism; D003261:Contact Lenses; D003315:Cornea / Q000378:metabolism; D065306:Corneal Injuries; D003319:Corneal Stroma / Q000378:metabolism / Q000648:ultrastructure; D004195:Disease Models, Animal; D004285:Dogs; D004337:Drug Carriers / Q000008:administration & dosage*; D019573:Epithelium, Corneal / Q000502:physiology / Q000648:ultrastructure; D005260:Female; D008297:Male; D046529:Microscopy, Electron, Transmission; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D024061:Collagen Type III; D004337:Drug Carriers; C059821:atelocollagen; D003094:Collagen