title: Primary infection with simian immunodeficiency virus: plasmacytoid dendritic cell homing to lymph nodes, type I interferon, and immune suppression.
abstract: Plasmacytoid dendritic cells (pDCs) are antigen-presenting cells that develop into type-I interferon (IFN-I)-producing cells in response to pathogens. Their role in human immunodeficiency virus (HIV) pathogenesis needs to be understood. We analyzed their dynamics in relation to innate and adaptive immunity very early during the acute phase of simian immunodeficiency virus (SIV) infection in 18 macaques. pDC counts decreased in blood and increased in peripheral lymph nodes, consistent with early recruitment in secondary lymphoid tissues. These changes correlated with the kinetic and intensity of viremia and were associated with a peak of plasma IFN-I. IFN-I and viremia were positively correlated with functional activity of the immune suppression associated enzyme indoleamine-2,3-dioxygenase (IDO) and FoxP3(+)CD8(+) T cells, which both negatively correlated with SIV-specific T-cell proliferation and CD4(+) T-cell activation. These data suggest that pDCs and IFN-I play a key role in shaping innate and adaptive immunity toward suppressive pathways during the acute phase of SIV/HIV primary infection.
authors.affiliation: Division of Immuno-Virology SIV, Commissariat à l'Energie Atomique, Institute of Emerging Diseases and Innovative Therapies IMETI, Fontenay-aux-Roses, Université Paris-Sud, Unité Mixte de Recherche E01, Orsay, France
authors.forename: Benoît
authors.initials: B
authors.lastname: Malleret
authors.forename: Benjamin
authors.initials: B
authors.lastname: Manéglier
authors.forename: Ingrid
authors.initials: I
authors.lastname: Karlsson
authors.forename: Pierre
authors.initials: P
authors.lastname: Lebon
authors.forename: Michelina
authors.initials: M
authors.lastname: Nascimbeni
authors.forename: Leïla
authors.initials: L
authors.lastname: Perié
authors.forename: Patricia
authors.initials: P
authors.lastname: Brochard
authors.forename: Benoît
authors.initials: B
authors.lastname: Delache
authors.forename: Julien
authors.initials: J
authors.lastname: Calvo
authors.forename: Thibault
authors.initials: T
authors.lastname: Andrieu
authors.forename: Odile
authors.initials: O
authors.lastname: Spreux-Varoquaux
authors.forename: Anne
authors.initials: A
authors.lastname: Hosmalin
authors.forename: Roger
authors.initials: R
authors.lastname: Le Grand
authors.forename: Bruno
authors.initials: B
authors.lastname: Vaslin
mesh_terms: D000210:Acute-Phase Reaction / Q000276:immunology; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000473:pathology; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism / Q000473:pathology; D002465:Cell Movement / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism / Q000473:pathology / Q000502:physiology; D007108:Immune Tolerance / Q000276:immunology*; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000378:metabolism; D007370:Interferon Type I / Q000097:blood*; D020382:Interleukin-18 / Q000378:metabolism; D053645:Interleukin-2 Receptor alpha Subunit / Q000378:metabolism; D008198:Lymph Nodes / Q000276:immunology*; D008252:Macaca fascicularis; D016097:Simian Acquired Immunodeficiency Syndrome / Q000097:blood / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D015302:Simian Immunodeficiency Virus / Q000276:immunology; D014766:Viremia / Q000276:immunology / Q000378:metabolism
chemical_list: D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D007370:Interferon Type I; D020382:Interleukin-18; D053645:Interleukin-2 Receptor alpha Subunit