title: MRI diagnosis of brown tumor based on magnetic susceptibility.
abstract: A 56-year-old male with chronic renal failure was incidentally found to have lytic bone lesions in the pubic symphysis, left femoral head, left acetabulum, left iliac bone, and L1 vertebra on computed tomography (CT). Subsequent magnetic resonance imaging (MRI) of the abdomen was performed (for evaluation of a renal lesion) which demonstrated marked loss of signal intensity in the L1 bone lesion on increasing TE gradient echo images, consistent with magnetic susceptibility effect due to hemosiderin. Brown tumor was confirmed at biopsy. The susceptibility imaging probes one particular histological characteristic of tissues and allows a restricted differential of lytic tumors that contain significant hemosiderin, including brown tumor.
authors.affiliation: Department of Radiology, University of Arizona Medical Center, Tucson, Arizona 85718, USA.
authors.forename: Negar G
authors.initials: NG
authors.lastname: Knowles
authors.forename: Deven L
authors.initials: DL
authors.lastname: Smith
authors.forename: Eric K
authors.initials: EK
authors.lastname: Outwater
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010002:Osteitis Fibrosa Cystica / Q000175:diagnosis*