The influence of lactose pseudopolymorphic form on salbutamol sulfate-lactose interactions in DPI formulations.
A series of 63- to 90-microm sieve-fractioned lactose pseudopolymorphs were investigated in terms of carrier functionality for dry powder inhaler (DPI) formulations. Stable alpha-anhydrous, alpha-monohydrate, and beta-anhydrous were chosen as model pseudopolymorphs. In addition, the beta-anhydrous was further purified to remove residual alpha-monohydrate content (beta-treated). The carriers were investigated in terms of morphology, particle size, crystallinity, and surface energy using inverse gas chromatography. Furthermore, the lactose samples carrier performance was evaluated by studying the aerosolization efficiency of the model drug, micronized salbutamol sulfate, from drug-carrier blends using a next generation impactor (NGI). In general, the aerosol performance of drug from carrier followed the rank order alpha-monohydrate > beta-anhydrous > beta-treated > alpha-anhydrous. Significant difference in carrier size was observed, specifically with relation to the amount of fines (where a rank order of beta-treated > beta-anhydrous > alpha-monohydrate > alpha-anhydrous. No direct relationship between fine content and particle morphology was observed. In comparison, an inverse relationship between surface energy and aerosolization efficiency was found, where a plot of fine particle fraction (aerodynamic diameter < 4.46 microm) against total surface energy resulted in R(2) = .977. Such observations are most likely due to increased particle carrier adhesion and reduced drug liberation during the aerosolization process, indicating surface chemistry (in this case due to the existence of different pseudopolymorphs) to play a dominating role in DPI systems.
Traini
Daniela
D
Advanced Drug Delivery Group, Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia. danielat@pharm.usyd.edu.au
Young
Paul M
PM
Thielmann
Frank
F
Acharya
Manaswini
M
D000336:Aerosols; D000420:Albuterol / Q000008:administration & dosage / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D002849:Chromatography, Gas; D007785:Lactose / Q000737:chemistry*; D008853:Microscopy; D009330:Nebulizers and Vaporizers; D010316:Particle Size; D014961:X-Ray Diffraction
D000336:Aerosols; D007785:Lactose; D000420:Albuterol