title: Catalytic asymmetric vinylogous mannich reaction of N-(2-thienyl)sulfonylimines.
abstract: Both cyclic and acyclic silyl dienol ethers participate efficiently in the asymmetric vinylogous Mannich reaction of N-2-thienylsulfonylimines catalyzed by copper(I) complexes of Fesulphos ligands. This procedure displays wide imine and nucleophile versatility, high enantiocontrol, and complete gamma-regioselectivity in most cases examined. The mild sulfonamide deprotection allows the resulting products to be readily transformed into optically active delta-lactams or 5-hydroxy-2-piperidone derivatives.
authors.affiliation: Departamento de Química Orgánica, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
authors.forename: Alvaro
authors.initials: A
authors.lastname: Salvador González
authors.forename: Ramón
authors.initials: R
authors.lastname: Gómez Arrayás
authors.forename: Marta
authors.initials: M
authors.lastname: Rodríguez Rivero
authors.forename: Juan C
authors.initials: JC
authors.lastname: Carretero