title: Congenital deformities and developmental abnormalities of the mandibular condyle in the temporomandibular joint.
abstract: The temporomandibular joint (TMJ) consists of the mandibular condyle and the articular eminence of the temporal bone. The morphological development of the TMJ during prenatal life lags behind other joints in terms of both the timing of its appearance and its progress. At birth, the joint is still largely underdeveloped. There are many causes of the various growth disturbances and abnormalities of the mandibular condyle and related structures. Growth disturbances in the development of the mandibular condyle may occur in utero late in the first trimester and may result in disorders such as aplasia or hypoplasia of the mandibular condyle. Meanwhile, hyperplasia of the mandibular condyle is not visible at birth and seems to be gradually acquired during growth. In the present review article, the congenital abnormalities of the mandibular condyle are classified morphologically into three major groups and two subgroups from a clinical standpoint: (1) hypoplasia or aplasia of the mandibular condyle, including (i) primary condylar aplasia and hypoplasia, (ii) secondary condylar hypoplasia; (2) hyperplasia; and (3) bifidity. In addition, the molecular-based etiology of anomalies of the mandibular condyle is also discussed.
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Medicine, Kanazawa Medical University, Ishikawa, Japan. k-k@kanazawa-med.ac.jp
authors.forename: Keiseki
authors.initials: K
authors.lastname: Kaneyama
authors.forename: Natsuki
authors.initials: N
authors.lastname: Segami
authors.forename: Toshihisa
authors.initials: T
authors.lastname: Hatta
mesh_terms: D000293:Adolescent; D000328:Adult; D001934:Branchial Region / Q000002:abnormalities / Q000196:embryology; D003394:Craniofacial Dysostosis / Q000196:embryology / Q000473:pathology; D005260:Female; D006053:Goldenhar Syndrome / Q000196:embryology / Q000473:pathology; D006801:Humans; D006965:Hyperplasia / Q000196:embryology; D007231:Infant, Newborn; D008297:Male; D008335:Mandibular Condyle / Q000002:abnormalities* / Q000196:embryology; D008059:Mucopolysaccharidosis I / Q000196:embryology / Q000473:pathology; D011247:Pregnancy; D013577:Syndrome; D013704:Temporomandibular Joint / Q000002:abnormalities* / Q000196:embryology