title: A highly stereoselective organocatalytic tandem aminoxylation/aza-Michael reaction for the synthesis of tetrahydro-1,2-oxazines.
abstract: A facile stereoselective synthesis of multifunctionalized tetrahydro-1,2-oxazines (THOs) has been achieved by the organocatalyzed asymmetric tandem alpha-aminoxylation/aza-Michael reaction for the C-O/C-N bond formations in moderate to good yields with excellent diastereo- (>99:1 dr) and enantioselectivities (92% to >99% ee).
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.
authors.forename: Di
authors.initials: D
authors.lastname: Zhu
authors.forename: Min
authors.initials: M
authors.lastname: Lu
authors.forename: Pei Juan
authors.initials: PJ
authors.lastname: Chua
authors.forename: Bin
authors.initials: B
authors.lastname: Tan
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.forename: Xinhao
authors.initials: X
authors.lastname: Yang
authors.forename: Guofu
authors.initials: G
authors.lastname: Zhong
mesh_terms: D000588:Amines / Q000737:chemistry*; D001372:Aza Compounds / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D006834:Hydrazines / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D055601:Organic Chemistry Phenomena; D010078:Oxazines / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction; D012997:Solvents
chemical_list: D000588:Amines; D001372:Aza Compounds; D006834:Hydrazines; D010078:Oxazines; D012997:Solvents; C029424:hydrazine; D006859:Hydrogen