title: A bifurcated pathway to thiazoles and imidazoles using a modular flow microreactor.
abstract: A scalable method for the preparation of 4,5-disubstituted thiazoles and imidazoles as distinct regioisomeric products using a modular flow microreactor has been devised. The process makes use of microfluidic reaction chips and packed immobilized-reagent columns to effect bifurcation of the reaction pathway.
authors.affiliation: Innovative Technology Centre (ACS), Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, U.K.
authors.forename: Ian R
authors.initials: IR
authors.lastname: Baxendale
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Smith
authors.forename: Lucia
authors.initials: L
authors.lastname: Tamborini
authors.forename: Ana-Florina
authors.initials: AF
authors.lastname: Voica
mesh_terms: D020650:Combinatorial Chemistry Techniques; D007093:Imidazoles / Q000138:chemical synthesis*; D008832:Microchemistry / Q000379:methods; D046210:Microfluidic Analytical Techniques / Q000379:methods*; D013844:Thiazoles / Q000138:chemical synthesis*
chemical_list: D007093:Imidazoles; D013844:Thiazoles