Etiology and short-term prognosis of severe mitral regurgitation.
OBJECTIVE
To describe the etiology and to document the course of severe mitral regurgitation (MR).


METHODS
Prospective registry of 272 patients diagnosed with chronic severe MR in an echocardiographic study.


RESULTS
Mean age was 70.2 +/- 13.8 years and 143 patients were women (53%). The most frequent causes of regurgitation were rheumatic disease (72 patients; 26%), ischemic etiology (58; 21%), valve prolapse (57; 21%), and dilated cardiomyopathy (49; 18%). A total of 43 patients (16%) died during follow-up (mean 0.9 +/- 0.3 years, total 2,785 patient-months): 30 from cardiac causes, 9 from non-cardiac causes, and 4 from unknown causes. Actuarial transplant-free survival was 87% at 6 months, and 81% at 1 year. Renal disease, previous stroke, ischemic etiology, and poor left ventricular ejection fraction were independent predictors of mortality.


CONCLUSIONS
Rheumatic disease is still the main cause of severe MR in Spain. Patients with severe MR have advanced age and present poor short-term prognosis.
Martínez-Sellés
Manuel
M
Cardiology Department, Hospital Universitario Gregorio Marañón, Dr. Esquerdo, 46, 28007 Madrid, Spain. mmselles@secardiologia.es
García-Fernández
Miguel Angel
MA
Larios
Edith
E
Moreno
Mar
M
Pinto
Angel
A
García-Robles
José Antonio
JA
Pérez-David
Esther
E
Fernández-Avilés
Francisco
F
D000368:Aged; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D008944:Mitral Valve Insufficiency / Q000209:etiology* / Q000503:physiopathology*; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012042:Registries; D013030:Spain; D015996:Survival Rate
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