[Quetiapine-induced leucopenia].
We describe the case of a 20-year-old man with schizophrenia who was treated with the dibenzothiazepine antipsychotic drug quetiapine in oral doses of 900 mg daily. At admission the patient had a normal blood count. 15 weeks after initiation of treatment asymptomatic cytopenia was discovered with leucocytes of 2.2 billion/l and thrombocytes of 114 billion/l. Two weeks after discontinuation of quetiapine the leucopenia subsided. Physicians should be aware of leucopenia as a potential adverse effect to quetiapine, especially in patients with symptoms of infections or cytopenia.
Penninga
Elisabeth I
EI
Klinisk Farmakologisk Enhed, Bispebjerg Hospital, DK-2400 København NV. ip08@bbh.hosp.dk
Dalhoff
Kim Peder
KP
Lykkegaard
Signe E
SE
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D003987:Dibenzothiazepines / Q000009:adverse effects*; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced*; D008297:Male; D000069348:Quetiapine Fumarate; D012559:Schizophrenia / Q000188:drug therapy
D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate