title: Treatment failure in Haemophilus influenzae due to a beta-lactamase low-level ampicillin-resistant organism.
abstract: Haemophilus influenzae is a rare causative organism of vertebral osteomyelitis in an adult. Cases reported in the literature were mainly caused by ampicillin-susceptible type b strains. Here we describe the first case of vertebral osteomyelitis due to a non-typeable, beta-lactamase low-level ampicillin-resistant H. influenzae strain with failure of prolonged intravenous amoxicillin treatment.
authors.affiliation: Department of Infectious Diseases, C5-P, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.
authors.forename: Vishnu
authors.initials: V
authors.lastname: van der Ploeg
authors.forename: Luc B S
authors.initials: LB
authors.lastname: Gelinck
authors.forename: Iris J A M
authors.initials: IJ
authors.lastname: Jonkers
authors.forename: Jacqueline S
authors.initials: JS
authors.lastname: Mourer
authors.forename: Alje P
authors.initials: AP
authors.lastname: van Dam
mesh_terms: D000368:Aged; D000658:Amoxicillin / Q000627:therapeutic use*; D000668:Ampicillin Resistance; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D006192:Haemophilus Infections / Q000188:drug therapy* / Q000382:microbiology; D006193:Haemophilus influenzae / Q000187:drug effects* / Q000201:enzymology / Q000302:isolation & purification; D006801:Humans; D008297:Male; D010019:Osteomyelitis / Q000188:drug therapy* / Q000382:microbiology; D017211:Treatment Failure; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D000900:Anti-Bacterial Agents; D000658:Amoxicillin; D001618:beta-Lactamases