title: A rat model of chronic kidney disease-mineral bone disorder.
abstract: Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) is a newly defined syndrome encompassing patients with chronic kidney disease that have a triad of biochemical alterations in calcium, phosphorus and parathyroid hormone, vascular calcification, and bone abnormalities. Here we describe a novel Cy/+ rat model of slowly progressive kidney disease spontaneously developing the three components of CKD-MBD when fed a normal phosphorus diet. Since the renal disorder progressed 'naturally' we studied the effect of dietary manipulation during the course of the disease. Animals with early, but established, chronic kidney disease were fed a casein-based or a grain-based protein diet both of which had equivalent total phosphorus contents. The two different sources of dietary protein had profound effects on the progression of CKD-MBD, likely due to differences in intestinal bioavailability of phosphorus. Although both dietary treatments resulted in the same serum phosphorous levels, the casein-fed animals had increased urinary phosphorus excretion and elevated serum FGF23 compared to the grain-fed rats. This model should help identify early changes in the course of chronic kidney disease that may lead to CKD-MBD.
authors.affiliation: Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46260, USA. smoe@iupui.edu
authors.forename: Sharon M
authors.initials: SM
authors.lastname: Moe
authors.forename: Neal X
authors.initials: NX
authors.lastname: Chen
authors.forename: Mark F
authors.initials: MF
authors.lastname: Seifert
authors.forename: Rachel M
authors.initials: RM
authors.lastname: Sinders
authors.forename: Dana
authors.initials: D
authors.lastname: Duan
authors.forename: Xianming
authors.initials: X
authors.lastname: Chen
authors.forename: Yun
authors.initials: Y
authors.lastname: Liang
authors.forename: J Scott
authors.initials: JS
authors.lastname: Radcliff
authors.forename: Kenneth E
authors.initials: KE
authors.lastname: White
authors.forename: Vincent H
authors.initials: VH
authors.lastname: Gattone
mesh_terms: D000818:Animals; D002364:Caseins / Q000008:administration & dosage / Q000494:pharmacology; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000378:metabolism*; D004195:Disease Models, Animal; D018450:Disease Progression; D002523:Edible Grain; D005346:Fibroblast Growth Factors / Q000032:analysis; D007408:Intestinal Absorption; D007676:Kidney Failure, Chronic / Q000150:complications*; D008903:Minerals / Q000378:metabolism*; D010758:Phosphorus / Q000097:blood / Q000493:pharmacokinetics / Q000652:urine; D051381:Rats
chemical_list: D002364:Caseins; C505605:Fgf23 protein, rat; D008903:Minerals; D010758:Phosphorus; D005346:Fibroblast Growth Factors
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