Task-evoked BOLD responses are normal in areas of diaschisis after stroke.
OBJECTIVE
Cerebral infarction can cause diaschisis, a reduction of blood flow and metabolism in areas of the cortex distant from the site of the lesion. Although the functional magnetic resonance imaging (fMRI) blood oxygen level dependent (BOLD) signal is increasingly used to examine the neural correlates of recovery in stroke, its reliability in areas of diaschisis is uncertain.


METHODS
The effect of chronic diaschisis as measured by resting positron emission tomography on task-evoked BOLD responses during word-stem completion in a block design fMRI study was examined in 3 patients, 6 months after a single left hemisphere stroke involving the inferior frontal gyrus and operculum.


RESULTS
The BOLD responses were minimally affected in areas of chronic diaschisis.


CONCLUSIONS
Within the confines of this study, the mechanism underlying the BOLD signal, which includes a mismatch between neuronally driven increases in blood flow and a corresponding increase in oxygen use, appears to be intact in areas of chronic diaschisis.
Fair
Damien A
DA
Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA. damien.fair@wustl.edu
Snyder
Abraham Z
AZ
Connor
Lisa Tabor
LT
Nardos
Binyam
B
Corbetta
Maurizio
M
D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D001931:Brain Mapping; D002536:Cerebral Arteries / Q000473:pathology / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology*; D007091:Image Processing, Computer-Assisted; D007806:Language Disorders / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009483:Neuropsychological Tests; D010101:Oxygen Consumption / Q000502:physiology; D049268:Positron-Emission Tomography / Q000379:methods*; D011237:Predictive Value of Tests; D020521:Stroke / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology*
Stroke. 1990 Jan;21(1):52-5
2300991
Curr Opin Neurol. 2004 Dec;17(6):705-9
15542979
Neurology. 2000 Dec 26;55(12):1883-94
11134389
AJNR Am J Neuroradiol. 2004 Jan;25(1):92-6
14729536
Magn Reson Med. 1999 Jun;41(6):1152-61
10371447
J Neurosci. 2008 Jan 30;28(5):1022-9
18234880
Brain Res. 1989 Dec 18;504(2):338-42
2598034
J Physiol. 1890 Jan;11(1-2):85-158.17
16991945
Stroke. 2006 Oct;37(10):2514-20
16946162
Stroke. 1993 Jan;24(1):84-7
8418556
Clin Nucl Med. 1992 Jul;17(7):581-6
1638841
Magn Reson Med. 1994 Dec;32(6):749-63
7869897
Arch Neurol. 2004 Feb;61(2):283-8
14967781
Annu Rev Neurosci. 2006;29:449-76
16776593
Ann Nucl Med. 2002 Jun;16(4):249-54
12126094
Trans Am Neurol Assoc. 1981;105:459-61
19645126
Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1834-9
9465103
J Cereb Blood Flow Metab. 2000 Aug;20(8):1149-65
10950376
Neurorehabil Neural Repair. 2007 Sep-Oct;21(5):412-28
17369516
Nat Neurosci. 2005 Nov;8(11):1603-10
16234807
Proc Natl Acad Sci U S A. 2002 May 28;99(11):7699-704
12032346
Stroke. 1988 Jul;19(7):840-5
3133840