title: ppGpp analogues as antibacterial compounds.
abstract: Immediately after sensing the inception of amino acid starvation, bacteria respond pleiotropically with the stringent response via RelA, mainly resulting in the accumulation of the signal molecule (p)ppGpp. A series of analogues of ppGpp that inhibit RelA activity was prepared in order to control the ability of bacteria cells to react to the changes in their environment. Some of those compounds presented very clear inhibitory effect on both Gram positive and negative bacteria in vitro.
authors.affiliation: Hebrew University of Jerusalem, School of Pharmacy, Department of Medicinal Chemistry and Natural Products, Jerusalem, Israel.
authors.forename: Wexselblatt
authors.initials: W
authors.lastname: Ezequiel
authors.forename: Katzhendler
authors.initials: K
authors.lastname: Jehoshua
authors.forename: Glaser
authors.initials: G
authors.lastname: Gad
authors.forename: Vidavski
authors.initials: V
authors.lastname: Roee
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D006159:Guanosine Tetraphosphate / Q000031:analogs & derivatives*; D008025:Ligases / Q000037:antagonists & inhibitors*
chemical_list: D000900:Anti-Bacterial Agents; D006159:Guanosine Tetraphosphate; D008025:Ligases; C028812:guanosine 3',5'-polyphosphate synthetases