Translating the Diabetes Prevention Program into the community. The DEPLOY Pilot Study.
BACKGROUND
The Diabetes Prevention Program (DPP) found that an intensive lifestyle intervention can reduce the development of diabetes by more than half in adults with prediabetes, but there is little information about the feasibility of offering such an intervention in community settings. This study evaluated the delivery of a group-based DPP lifestyle intervention in partnership with the YMCA.


METHODS
This pilot cluster-randomized trial was designed to compare group-based DPP lifestyle intervention delivery by the YMCA to brief counseling alone (control) in adults who attended a diabetes risk-screening event at one of two semi-urban YMCA facilities and who had a BMI>or=24 kg/m2, >or=2 diabetes risk factors, and a random capillary blood glucose of 110-199 mg/dL. Multivariate regression was used to compare between-group differences in changes in body weight, blood pressures, HbA1c, total cholesterol, and HDL-cholesterol after 6 and 12 months.


RESULTS
Among 92 participants, controls were more often women (61% vs 50%) and of nonwhite race (29% vs 7%). After 6 months, body weight decreased by 6.0% (95% CI=4.7, 7.3) in intervention participants and 2.0% (95% CI=0.6, 3.3) in controls (p<0.001; difference between groups). Intervention participants also had greater changes in total cholesterol (-22 mg/dL vs +6 mg/dL controls; p<0.001). These differences were sustained after 12 months, and adjustment for differences in race and gender did not alter these findings. With only two matched YMCA sites, it was not possible to adjust for potential clustering by site.


CONCLUSIONS
The YMCA may be a promising channel for wide-scale dissemination of a low-cost approach to lifestyle diabetes prevention.
Ackermann
Ronald T
RT
Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. rtackerm@iupui.edu
Finch
Emily A
EA
Brizendine
Edward
E
Zhou
Honghong
H
Marrero
David G
DG
D003376:Counseling; D003920:Diabetes Mellitus / Q000517:prevention & control*; D005260:Female; D006293:Health Promotion; D006801:Humans; D016018:Least-Squares Analysis; D008019:Life Style; D008297:Male; D008875:Middle Aged; D010353:Patient Education as Topic; D010865:Pilot Projects; D015397:Program Evaluation; D014481:United States
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