One or two enzyme-linked immunosorbent assay tests on the first serum sample for initial diagnosis of HIV-1 infection?
In France, the first sample for the initial diagnosis of HIV-1 infection must be tested with two antibody assays: one being an enzyme-linked immunosorbent assay. If one is positive, confirmation tests are performed. We evaluated the performance of initial diagnostic strategies based on the use of one versus two enzyme-linked immunosorbent assay tests, either an antigen-antibody test or a simple antibody assay. We found that a single antigen-antibody test was more efficient than a combination of the two tests.
Costagliola
Dominique
D
INSERM, U 720, Paris, France. dcostagliola@ccde.chups.jussieu.fr
Damond
Florence
F
Palmer
Pierre
P
Rouzioux
Christine
C
Brun-Vezinet
Françoise
F
D015492:AIDS Serodiagnosis / Q000379:methods*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D015658:HIV Infections / Q000175:diagnosis*; D015497:HIV-1; D006801:Humans; D012680:Sensitivity and Specificity