Risk stratification in acute decompensated heart failure: the role of cardiac troponin.
Cardiac troponins provide important prognostic information in patients with acute decompensated heart failure. In a large study by the ADHERE Investigators, 6.2% of 67,924 patients with acute decompensated heart failure were positive for cardiac troponin; these individuals had lower blood pressure and lower ejection fraction than those who were negative for troponin. The study revealed that in-hospital mortality was significantly higher for troponin-positive patients than for troponin-negative individuals (8.0% vs 2.7%; P<0.001). Future studies need to define which treatment changes could improve outcome in troponin-positive patients with acute decompensated heart failure.
Mueller
Christian
C
University of Basel and Internal Medicine at University Hospital Basel, Basel, Switzerland. chmueller@uhbs.ch
D000208:Acute Disease; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D006333:Heart Failure / Q000097:blood* / Q000401:mortality* / Q000503:physiopathology / Q000628:therapy; D017052:Hospital Mortality; D006801:Humans; D016017:Odds Ratio; D018570:Risk Assessment; D013318:Stroke Volume; D016896:Treatment Outcome; D014336:Troponin / Q000097:blood*
D015415:Biomarkers; D014336:Troponin