Synthesis and properties of covalently linked antiparallel and parallel DNA duplexes.
We synthesized covalently linked antiparallel stranded (aps) and parallel stranded (ps) DNA duplexes. These modified duplexes contained an ethylene-linked T-T base pair at the duplex end. Thermal denaturation analysis of these modified duplexes indicated that the aps and ps DNA duplexes have similar thermal stabilities.
Ono
Takashi
T
Department of Material and Life Chemistry, Faculty of Engineering, Kanagawa University, Yokohama, Kanagawa 221-8686, Japan.
Saotome
Yuko
Y
Okamoto
Itaru
I
Ono
Akira
A
D004247:DNA / Q000138:chemical synthesis* / Q000737:chemistry; D009691:Nucleic Acid Denaturation; D009943:Organophosphorus Compounds / Q000737:chemistry; D013696:Temperature; D013941:Thymine / Q000737:chemistry
D009943:Organophosphorus Compounds; C434331:phosphoramidite; D004247:DNA; D013941:Thymine