Significant effect of dimethylsulfoniopropionate on Parkinson's disease of senescence-accelerated mice induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
The induction of Parkinson's disease (PD) in senescence-accelerated mice (SAMP8) by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and the effects of dimethylsulfoniopropionate (DMSP) on induced PD model mice of SAMP8 were investigated for 5 wk. After many trials, the tail suspension test determining the PD symptoms indicated that an appropriate amount of MPTP clearly raises the SAMP8 mice to the PD-model mice. Moreover, DMSP administration to the PD-SAM model mice proved to completely reduce the PD symptoms in the mice and to accumulate large amounts of norepinephrine, dopamine and dioxyphenylacetate in the mouse brains without cerebellums. These results suggest that catecholamines accumulated in large quantities by the supplementation of DMSP to the double-diseased mice, PD-SAMP8 model mice, completely ameliorated the PD symptoms in these model mice.
Minematsu
Masaharu
M
Department of Nutritional Sciences for Well-being, Kansai University of Welfare Sciences 3-11-1, Asahigaoka, Kashiwara, Osaka 582-0026, Japan.
Nakajima
Kenji
K
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000494:pharmacology; D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000375:Aging; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D007103:Immobilization; D020267:MPTP Poisoning / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D051379:Mice; D009498:Neurotoxins / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism; D013452:Sulfonium Compounds / Q000494:pharmacology*; D014202:Tremor / Q000188:drug therapy
D009498:Neurotoxins; D013452:Sulfonium Compounds; D015102:3,4-Dihydroxyphenylacetic Acid; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; C068078:dimethylpropiothetin; D004298:Dopamine; D009638:Norepinephrine