title: Radiological classification of optic pathway gliomas: experience of a modified functional classification system.
abstract: Optic pathway gliomas (OPGs) in childhood are associated with neurofibromatosis type 1 (NF1) and since 1958 have been classified anatomically using the Dodge classification (DC). MR scanning permits a more detailed anatomical description than can be classified by this historical system. A modified Dodge classification (MDC) has been applied to MRI scans from a cohort of 72 patients (36.1% NF1-positive) from 4 centres participating in an international clinical trial. The MDC was feasible, applicable and more detailed than the original DC. NF1-positive cases more commonly involved both optic nerves (p = 0.021) and other multiple locations (p = 0.001). NF1-negative tumours more commonly involved the central chiasm (p = 0.005) and hypothalamus (p = 0.003). Fewer hypothalamus-positive tumours were associated with optic nerve involvement (p = 0.009), whereas more were associated with central chiasm involvement (p<0.001). From diagnosis to follow-up, there was concordance between DC and MDC in 51/72 cases (70.8%). The MDC is therefore proposed for use in clinical trials of new treatments for OPGs.
authors.affiliation: Nottingham University Hospitals NHS Trust, Queen's Medical Centre, Nottingham NG7 2UH, UK.
authors.forename: T
authors.initials: T
authors.lastname: Taylor
authors.forename: T
authors.initials: T
authors.lastname: Jaspan
authors.forename: G
authors.initials: G
authors.lastname: Milano
authors.forename: R
authors.initials: R
authors.lastname: Gregson
authors.forename: T
authors.initials: T
authors.lastname: Parker
authors.forename: T
authors.initials: T
authors.lastname: Ritzmann
authors.forename: C
authors.initials: C
authors.lastname: Benson
authors.forename: D
authors.initials: D
authors.lastname: Walker
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007029:Hypothalamic Neoplasms / Q000145:classification* / Q000175:diagnosis; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009456:Neurofibromatosis 1 / Q000150:complications; D020339:Optic Nerve Glioma / Q000145:classification* / Q000175:diagnosis; D019574:Optic Nerve Neoplasms / Q000145:classification* / Q000175:diagnosis; D010865:Pilot Projects; D011379:Prognosis; D016896:Treatment Outcome