Modification of the side chain of micromolide, an anti-tuberculosis natural product.
This paper describes a series of modifications of the side chain of micromolide, an anti-tuberculosis natural product. Most of the synthesized compounds showed significantly decreased activities, which suggests that the long aliphatic side chain of micromolide and its double bond are essential to its activity.
Yuan
Hai
H
Drug Discovery Program, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA.
He
Rong
R
Wan
Baojie
B
Wang
Yuehong
Y
Pauli
Guido F
GF
Franzblau
Scott G
SG
Kozikowski
Alan P
AP
D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001688:Biological Products / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry; D013329:Structure-Activity Relationship; D014376:Tuberculosis / Q000188:drug therapy*
D000475:Alkenes; D000995:Antitubercular Agents; D001688:Biological Products; D007783:Lactones; C532529:micromolide