Counteracting clotting in sepsis.
The complexity of factors that regulate bleeding and coagulation has long confounded researchers. Andrew Wei and Shaun Jackson help clear the air by examining clinical findings pointing to a mechanistic basis for a common bleeding disorder, immune thrombocytopenic purpura. Mark Kahn tackles two research studies that could lead to improved therapies for a coagulation syndrome that hits people with severe sepsis.
Kahn
Mark L
ML
University of Pennsylvania, 925 BRB II/III, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA. markkahn@med.upenn.edu
D001777:Blood Coagulation / Q000502:physiology*; D006801:Humans; D011486:Protein C / Q000378:metabolism; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood*; D044463:Receptor, PAR-1 / Q000378:metabolism*; D018805:Sepsis / Q000097:blood / Q000628:therapy*
D011486:Protein C; D044463:Receptor, PAR-1