title: Parathyroid hormone and the cardiovascular system.
abstract: The classical actions of parathyroid hormone (PTH) are well recognized, but its effects on other target tissues, such as the cardiovascular system, are less appreciated. Several studies have evaluated the effects of PTH in patients with primary hyperparathyroidism in order to understand potential cardiovascular effects in terms of hypertension, cardiovascular mortality, left ventricular function, and endothelial function. We review these studies and evaluate the cellular mechanisms that may affect these outcomes.
authors.affiliation: Research and Development, Musculoskeletal Diseases, GlaxoSmithKline, 2301 Renaissance Boulevard, RN0420, King of Prussia, PA 19406, USA. lorraine.a.fitzpatrick@gsk.com
authors.forename: Lorraine A
authors.initials: LA
authors.lastname: Fitzpatrick
authors.forename: John P
authors.initials: JP
authors.lastname: Bilezikian
authors.forename: Shonni J
authors.initials: SJ
authors.lastname: Silverberg
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000503:physiopathology; D002319:Cardiovascular System / Q000503:physiopathology*; D004195:Disease Models, Animal; D006801:Humans; D006961:Hyperparathyroidism / Q000503:physiopathology; D006973:Hypertension / Q000503:physiopathology; D010281:Parathyroid Hormone / Q000502:physiology*; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology
chemical_list: D010281:Parathyroid Hormone
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