title: Comparison of perceived itch induced by skin prick-tests with histamine and codeine.
abstract: The role of personal factors makes it difficult to correlate subjective data, such as those obtained with the use of a visual analogue scale, and objective data, such as a quantity of injected histamine. In this study, prick tests with histamine and codeine on the forearms allowed a coherent variation in itch scores to be obtained over time, with highly significant differences from controls and with a peak at 4 minutes. These tests are therefore valuable for screening anti-pruritic agents. A significant difference between initial scores and scores for new prick tests after 7 days suggest that tachyphylaxis persists.
authors.affiliation: Pierre Fabre Research Institute, Toulouse, France.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Theunis
authors.forename: David
authors.initials: D
authors.lastname: Black
authors.forename: Arnaud
authors.initials: A
authors.lastname: Degouy
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Schmitt
authors.forename: Laurent
authors.initials: L
authors.lastname: Misery
mesh_terms: D000293:Adolescent; D000328:Adult; D000701:Analgesics, Opioid; D003061:Codeine; D004311:Double-Blind Method; D006632:Histamine; D017442:Histamine Agonists; D006801:Humans; D008297:Male; D011537:Pruritus / Q000139:chemically induced*; D012720:Severity of Illness Index; D012882:Skin Tests; D055815:Young Adult
chemical_list: D000701:Analgesics, Opioid; D017442:Histamine Agonists; D006632:Histamine; D003061:Codeine