title: Fast time-domain diffuse optical tomography using pseudorandom bit sequences.
abstract: We report a novel time-domain diffuse optical tomography to determine the optical properties in a faster speed than the conventional ones. Instead of using the ultrashort pulse laser, a 2.5 Gbps pseudorandom bit sequence is used to modulate the near-infrared light for tissue-like phantom illumination. The time-resolved signal can be retrieved very quickly by demodulation with the reference signal. The system impulse response has a full width at half maximum around 800 picoseconds and the 2-dimentional maps of optical properties can be obtained within a few seconds. The high signal-to-noise ratio and the environmental illumination insensitivity warrant a great potential for applications in clinical noninvasive breast cancer detection.
authors.affiliation: Division of Bioengineering, National University of Singapore, Singapore.
authors.forename: Weirong
authors.initials: W
authors.lastname: Mo
authors.forename: Nanguang
authors.initials: N
authors.lastname: Chen
mesh_terms: D003198:Computer Simulation; D017076:Computer-Aided Design; D003627:Data Interpretation, Statistical; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005336:Fiber Optic Technology / Q000295:instrumentation*; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods*; D008962:Models, Theoretical; D012815:Signal Processing, Computer-Assisted; D041622:Tomography, Optical / Q000379:methods*