Cytogenetic abnormality 46,XX,add(21)(q11.2) in a patient with follicular dendritic cell sarcoma.
The case of a patient with follicular dendritic cell (FDC) sarcoma with chromosomal aberration add(21)(q11.2) is described. Cytogenetic studies showed the karyotype 46,XX,add(21)(q11.2)[3]/46,XX[17], although the encoded protein involved was not clarified. The abnormal pattern was quite simple, and different from a previous report. The clinical course of the FDC sarcoma in this case has been indolent, as for most FDC sarcoma patients. Although this patient suffered from breast carcinoma 6 years after the onset of FDC sarcoma, the carcinoma showed different histological and phenotypic profiles.
Suzuki
Naomi
N
Tohoku University School of Medicine, Sendai, Japan.
Katsusihma
Hiroki
H
Takeuchi
Kengo
K
Nakamura
Shigeo
S
Ishizawa
Kenichi
K
Ishii
Seiichi
S
Moriya
Takuya
T
DeCoteau
John F
JF
Miura
Ikuo
I
Ichinohasama
Ryo
R
D002293:Adenocarcinoma, Scirrhous / Q000235:genetics; D001365:Axilla; D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000235:genetics; D018270:Carcinoma, Ductal, Breast / Q000235:genetics; D002869:Chromosome Aberrations; D002891:Chromosomes, Human, Pair 21; D054740:Dendritic Cell Sarcoma, Follicular / Q000235:genetics* / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D008198:Lymph Nodes / Q000473:pathology; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D009378:Neoplasms, Multiple Primary / Q000235:genetics*; D017464:Receptors, Complement 3d / Q000032:analysis
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D017464:Receptors, Complement 3d