Task-related modulation of visual neglect in cancellation tasks.
Unilateral neglect involves deficits of spatial exploration and awareness that do not always affect a fixed portion of extrapersonal space, but may vary with current stimulation and possibly with task demands. Here, we assessed any 'top-down', task-related influences on visual neglect, with novel experimental variants of the cancellation test. Many different versions of the cancellation test are used clinically, and can differ in the extent of neglect revealed, though the exact factors determining this are not fully understood. Few cancellation studies have isolated the influence of top-down factors, as typically the stimuli are changed also when comparing different tests. Within each of three cancellation studies here, we manipulated task factors, while keeping visual displays identical across conditions to equate purely bottom-up factors. Our results show that top-down task demands can significantly modulate neglect as revealed by cancellation on the same displays. Varying the target/non-target discrimination required for identical displays has a significant impact. Varying the judgement required can also have an impact on neglect even when all items are targets, so that non-targets no longer need filtering out. Requiring local versus global aspects of shape to be judged for the same displays also has a substantial impact, but the nature of discrimination required by the task still matters even when local/global level is held constant (e.g. for different colour discriminations on the same stimuli). Finally, an exploratory analysis of lesions among our neglect patients suggested that top-down task-related influences on neglect, as revealed by the new cancellation experiments here, might potentially depend on right superior temporal gyrus surviving the lesion.
Sarri
Margarita
M
UCL Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London WC1N 3AR, UK. m.sarri@ucl.ac.uk
Greenwood
Richard
R
Kalra
Lalit
L
Driver
Jon
J
D000328:Adult; D000368:Aged; D001288:Attention / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010364:Pattern Recognition, Visual / Q000502:physiology; D010468:Perceptual Disorders / Q000473:pathology / Q000503:physiopathology*; D010775:Photic Stimulation / Q000379:methods; D014794:Visual Fields / Q000502:physiology; D014796:Visual Perception / Q000502:physiology*; D055815:Young Adult
Neurology. 1973 Jun;23(6):658-64
4736313
J Clin Exp Neuropsychol. 2001 Oct;23(5):599-607
11778637
Nature. 1995 Feb 9;373(6514):521-3
7845464
J Exp Psychol Hum Percept Perform. 1995 Jun;21(3):451-68
7790827
J Neurosci. 2000 May 1;20(9):RC72
10777814
Neurocase. 2004 Feb;10(1):29-38
15849157
Nat Neurosci. 2005 Nov;8(11):1603-10
16234807
Neuropsychologia. 1994 Mar;32(3):275-88
8202223
Trends Cogn Sci. 2005 Feb;9(2):75-82
15668100
Nat Neurosci. 2003 May;6(5):448-50
12704393
J Exp Psychol Learn Mem Cogn. 1990 May;16(3):471-83
2140405
Brain Cogn. 2003 Nov;53(2):117-20
14607129
J Neurol Neurosurg Psychiatry. 2004 Sep;75(9):1356-8
15314135
J Neurosci. 1984 Jul;4(7):1863-74
6737043
J Cogn Neurosci. 2007 Jul;19(7):1081-8
17583985
Nat Rev Neurosci. 2003 Jan;4(1):26-36
12511859
Neuropsychologia. 1997 Nov;35(11):1425-36
9352520
Brain. 2007 Sep;130(Pt 9):2452-61
17660183
Neuron. 2007 Mar 15;53(6):905-18
17359924
Neurology. 1988 Aug;38(8):1207-11
3399068
J Neurol Neurosurg Psychiatry. 1993 Jun;56(6):717-9
8509794
J Neurol Neurosurg Psychiatry. 2002 Aug;73(2):160-6
12122175
Arch Phys Med Rehabil. 1987 Feb;68(2):98-102
3813864
J Neurosci. 1988 Oct;8(10):3757-69
3193178
J Cogn Neurosci. 1989 Fall;1(4):372-85
23971987
Neuroreport. 2006 May 29;17(8):833-6
16708024
Neuropsychologia. 2008 Jan 31;46(2):487-96
17945316
Psychol Rev. 1989 Jul;96(3):433-58
2756067
Neuropsychologia. 2006;44(12):2578-81
16750545
Int J Neurosci. 1992 Jan;62(1-2):45-56
1342013
Brain Cogn. 1998 Aug;37(3):439-59
9733559
Neuroreport. 2004 Oct 5;15(14):2189-93
15371731
Brain. 2007 Feb;130(Pt 2):431-41
17008330
Neurocase. 2006 Jun;12(3):127-35
16801148
J Exp Psychol Gen. 1985 Sep;114(3):285-310
3161978
Neuroimage. 2006 Oct 1;32(4):1747-59
16806986
Brain. 2004 Oct;127(Pt 10):2307-15
15292055
Brain Cogn. 1997 Aug;34(3):388-403
9292188
Brain. 2003 Sep;126(Pt 9):1986-97
12821519
Neuropsychologia. 1997 Jun;35(6):829-41
9204488
Neuroimage. 2007 May 1;35(4):1531-7
17391987
Cogn Psychol. 1980 Jan;12(1):97-136
7351125
Nature. 2001 Jun 21;411(6840):950-3
11418859
Cereb Cortex. 2005 Jun;15(6):870-6
15459080
Cortex. 1994 Sep;30(3):509-17
7805391
Int Disabil Stud. 1990 Jul-Sep;12(3):95-9
2096121
Cereb Cortex. 2005 Jun;15(6):770-86
15459076
Nature. 1998 Jul 2;394(6688):75-8
9665130
Behav Neurol. 2000;12(4):191-200
11568431
Cereb Cortex. 2004 Oct;14(10):1164-72
15142954
Neuropsychologia. 2006;44(3):436-44
16005032
Neuropsychologia. 2001;39(4):390-6
11164877
Arch Neurol. 1989 Feb;46(2):178-82
2916956
Philos Trans R Soc Lond B Biol Sci. 2007 May 29;362(1481):837-55
17395574
Neuropsychologia. 1992 Dec;30(12):1101-8
1484604
Arch Neurol. 1991 Dec;48(12):1263-6
1845031
Neuropsychologia. 2002;40(11):1794-803
12062891