Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer.
Three recent genome-wide association studies identified associations between markers in the chromosomal region 15q24-25.1 and the risk of lung cancer. We conducted a genome-wide association analysis to investigate associations between single-nucleotide polymorphisms (SNPs) and the risk of lung cancer, in which we used blood DNA from 194 case patients with familial lung cancer and 219 cancer-free control subjects. We identified associations between common sequence variants at 15q24-25.1 (that spanned LOC123688 [a hypothetical gene], PSMA4, CHRNA3, CHRNA5, and CHRNB4) and lung cancer. The risk of lung cancer was more than fivefold higher among those subjects who had both a family history of lung cancer and two copies of high-risk alleles rs8034191 (odds ratio [OR] = 7.20, 95% confidence interval [CI] = 2.21 to 23.37) or rs1051730 (OR = 5.67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects. Thus, further research to elucidate causal variants in the 15q24-25.1 locus that are associated with lung cancer is warranted.
Liu
Pengyuan
P
Washington University, St Louis, MO 63110, USA.
Vikis
Haris G
HG
Wang
Daolong
D
Lu
Yan
Y
Wang
Yian
Y
Schwartz
Ann G
AG
Pinney
Susan M
SM
Yang
Ping
P
de Andrade
Mariza
M
Petersen
Gloria M
GM
Wiest
Jonathan S
JS
Fain
Pamela R
PR
Gazdar
Adi
A
Gaba
Colette
C
Rothschild
Henry
H
Mandal
Diptasri
D
Coons
Teresa
T
Lee
Juwon
J
Kupert
Elena
E
Seminara
Daniela
D
Minna
John
J
Bailey-Wilson
Joan E
JE
Wu
Xifeng
X
Spitz
Margaret R
MR
Eisen
Timothy
T
Houlston
Richard S
RS
Amos
Christopher I
CI
Anderson
Marshall W
MW
You
Ming
M
D016022:Case-Control Studies; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics; D015986:Confounding Factors, Epidemiologic; D004273:DNA, Neoplasm / Q000032:analysis*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012107:Research Design; D017422:Sequence Analysis, DNA; D012907:Smoking / Q000009:adverse effects
D004273:DNA, Neoplasm
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