Perinatal choline deficiency produces abnormal sensory inhibition in Sprague-Dawley rats.
Adequate choline levels in rodents during gestation have been shown to be critical to several functions, including certain learning and memory functions, when tested at adulthood. Choline is a selective agonist for the alpha7 nicotinic receptor which appears in development before acetylcholine is present. Normal sensory inhibition is dependent, in part, upon sufficient numbers of this receptor in the hippocampus. The present study assessed sensory inhibition in Sprague-Dawley rats gestated on normal (1.1 g/kg), deficient (0 g/kg) or supplemented (5 g/kg) choline in the maternal diet during the critical period for cholinergic cell development (E12-18). Rats gestated on deficient choline showed abnormal sensory inhibition when tested at adulthood, while rats gestated on normal or supplemented choline showed normal sensory inhibition. Assessment of hippocampal alpha-bungarotoxin to visualize nicotinic alpha7 receptors revealed no difference between the gestational choline levels. These data suggest that attention to maternal choline levels for human pregnancy may be important to the normal functioning of the offspring.
Stevens
Karen E
KE
Medical Research Service, Department of Veterans Affairs Medical Center, Denver, CO, USA. karen.stevens@ucdenver.edu
Adams
Catherine E
CE
Mellott
Tiffany J
TJ
Robbins
Emily
E
Kisley
Michael A
MA
D000161:Acoustic Stimulation / Q000379:methods; D000818:Animals; D000831:Animals, Newborn; D002038:Bungarotoxins / Q000378:metabolism; D002794:Choline / Q000008:administration & dosage / Q000494:pharmacology*; D002796:Choline Deficiency / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory / Q000187:drug effects / Q000502:physiology; D005260:Female; D006624:Hippocampus / Q000378:metabolism; D007266:Inhibition, Psychological; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time; D013216:Reflex, Startle / Q000502:physiology
D002038:Bungarotoxins; D002794:Choline
Ann N Y Acad Sci. 1992 Jul 1;658:111-27
1497255
Schizophr Res. 1993 Aug;10(2):131-41
8398945
Front Integr Neurosci. 2008 May 03;1:7
18958235
Brain Res Dev Brain Res. 1999 Jun 2;115(2):123-9
10407130
Science. 1998 Aug 7;281(5378):794-5
9714685
Brain Res Dev Brain Res. 2000 Sep 30;123(1):25-32
11020547
Genes Dev. 1998 Aug 1;12(15):2245-62
9694791
FASEB J. 2004 Mar;18(3):545-7
14715695
Neurosci Lett. 1996 Aug 9;213(3):201-4
8873149
Neurosci Biobehav Rev. 2006;30(5):696-712
16504295
Neuroscience. 1993 Jul;55(2):373-80
7690909
Dev Biol. 1974 Jan;36(1):130-41
4822829
J Neurophysiol. 2004 Apr;91(4):1545-55
14645379
Biol Psychiatry. 1990 Jan 15;27(2):183-92
2294981
Brain Res. 1997 Nov 21;776(1-2):111-6
9439802
Brain Res. 1991 Jul 26;555(1):91-8
1681997
Nutrition. 2000 Jul-Aug;16(7-8):669-71
10906592
Psychopharmacology (Berl). 1998 Apr;136(4):320-7
9600576
J Neurosci. 1998 Feb 15;18(4):1187-95
9454829
Nature. 1977 Apr 28;266(5605):848-50
865607
Behav Neurosci. 1989 Dec;103(6):1234-41
2610916
FASEB J. 2006 Jan;20(1):43-9
16394266
Schizophr Bull. 1996;22(3):431-45
8873294
Neuropharmacology. 1992 Oct;31(10):1041-8
1436386
Prog Exp Pers Res. 1964;72:1-47
14348121
J Neurosci. 1993 May;13(5):1965-75
8478687
J Nutr. 2002 Jul;132(7):1840-7
12097657
Learn Mem. 2006 Mar-Apr;13(2):127-34
16547161
Am J Psychiatry. 1993 Dec;150(12):1856-61
8238642
J Neurochem. 2004 Jun;89(5):1252-9
15147518
Psychopharmacology (Berl). 2005 Nov;183(1):13-9
16136299
Brain Res. 1998 Jun 1;794(2):225-38
9622639
Dev Biol. 1974 Jan;36(1):142-54
4822830
Annu Rev Nutr. 1994;14:269-96
7946521
Biol Psychiatry. 1983 Sep;18(9):989-1005
6416309
Clin Chim Acta. 1985 Jun 30;149(1):1-12
4028430
J Comp Neurol. 1988 Mar 1;269(1):87-95
3361006
Neuropsychopharmacology. 1996 Aug;15(2):152-62
8840351
Psychopharmacology (Berl). 2008 Jun;198(3):413-20
18446322
Brain Res Dev Brain Res. 1999 Mar 12;113(1-2):13-20
10064869
Int J Psychophysiol. 2008 Feb;67(2):91-100
18036692
Proc Natl Acad Sci U S A. 1994 Mar 1;91(5):1731-5
8127873
Pharmacol Biochem Behav. 1997 Aug;57(4):869-74
9259018
Pharmacol Ther. 2002 Feb-Mar;93(2-3):125-33
12191605
Brain Res Dev Brain Res. 1999 Dec 10;118(1-2):159-67
10611515
Arch Gen Psychiatry. 2006 Jun;63(6):630-8
16754836
Eur J Neurosci. 1997 Dec;9(12):2734-42
9517478
Brain Res. 2002 Feb 22;928(1-2):85-95
11844475
J Pediatr. 2006 Nov;149(5 Suppl):S131-6
17212955
Neurosci Biobehav Rev. 2003 Sep;27(4):385-99
12946691
Brain Res Dev Brain Res. 1999 Dec 10;118(1-2):51-9
10611503
Neuroreport. 1997 Sep 29;8(14):3045-51
9331912
Eur J Pharmacol. 2000 Mar 30;393(1-3):237-42
10771019
Biol Psychiatry. 2003 Feb 1;53(3):244-53
12559658
Brain Res Dev Brain Res. 2002 Dec 15;139(2):175-87
12480132
Schizophr Bull. 1998;24(2):189-202
9613620
Biol Psychiatry. 1986 Jul;21(8-9):787-98
3730461