title: Helicobacter pylori induces gastritis and oxidative stress after distal gastrectomy.
abstract: OBJECTIVE
  Helicobacter pylori is a carcinogen for gastric cancer. There have been few reports on carcinogenesis about H. pylori infection in the gastric remnant after distal gastrectomy. The relationship between carcinogenesis and H. pylori infection was studied by means of inflammation and oxidative stress.
  
  
  METHODS
  Ninety-seven patients who had undergone curative distal gastrectomy for gastric cancer were studied. All patients underwent endoscopic examination 3 months after surgery. The presence of H. pylori was determined using urease rapid test, hematoxylin-eosin staining, and immunohistochemical staining. Fifty-one patients were positive (group A) and 46 patients were negative (group B). The grades of remnant gastritis were scored by updated Sydney System. 8-Hydroxydeoxyguanosine (8-OHdG) as an oxidative stress marker, was analyzed immunohistochemically, and graded in 4 grades.
  
  
  RESULTS
  Both the neutrophil infiltration score and 8-OHdG expression score was higher in group A than group B (p = 0.03 and 0.05). The correlation between the 8-OHdG expression score and the neutrophil infiltration score was significant (p = 0.02).
  
  
  CONCLUSIONS
  As gastritis is related to oxidative stress, H. pylori infection is suspected to play an important role in carcinogenesis in the gastric remnant.
authors.affiliation: Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abenoku, Osaka 545-8585, Japan. fuku@eva.hi-ho.ne.jp
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Fukuhara
authors.forename: Harushi
authors.initials: H
authors.lastname: Osugi
authors.forename: Masashi
authors.initials: M
authors.lastname: Takemura
authors.forename: Shigeru
authors.initials: S
authors.lastname: Lee
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Morimura
authors.forename: Satoru
authors.initials: S
authors.lastname: Kishida
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nishizawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Iwasaki
authors.forename: Ken
authors.initials: K
authors.lastname: Gyobu
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000378:metabolism; D005500:Follow-Up Studies; D005743:Gastrectomy / Q000009:adverse effects*; D005753:Gastric Mucosa / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D018530:Gastric Stump; D005756:Gastritis / Q000175:diagnosis / Q000378:metabolism / Q000382:microbiology*; D005763:Gastroenterostomy; D016481:Helicobacter Infections / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D016480:Helicobacter pylori; D006801:Humans; D018384:Oxidative Stress; D013274:Stomach Neoplasms / Q000378:metabolism / Q000382:microbiology* / Q000601:surgery
chemical_list: D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine