title: Rearranged and unrearranged angucyclinones from Indonesian Streptomyces spp.
abstract: Two Indonesian Streptomyces strains, ICBB8309 and ICBB8415, were investigated for their ability to produce antibiotic compounds. In addition to the known antibiotics actiphenol, naramycin B, and sabaramycin, six new angucyclinones were identified. The isolation, structure elucidation and biological activities for the six new compounds are presented. The angucyclinones 7-deoxo-6-deoxy-7-hydroxy-8-O-methylrabelomycin, 1-deoxo-1-hydroxy-8-O-methylrabelomycin, and the angucycline 7-deoxo-7-hydroxy-1-O-alpha-rhamnosyl-8-O-methyltetrangulol have common angular backbones, while angucyclinone C, limamycin A, and limamycin B appear to be rearranged angucyclinones.
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, Corvallis, Oregon 97331-3507, USA.
authors.forename: Serge
authors.initials: S
authors.lastname: Fotso
authors.forename: Taifo
authors.initials: T
authors.lastname: Mahmud
authors.forename: T Mark
authors.initials: TM
authors.lastname: Zabriskie
authors.forename: Dwi Andreas
authors.initials: DA
authors.lastname: Santosa
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Proteau
mesh_terms: D000880:Anthraquinones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D007214:Indonesia; D020102:Mycobacterium smegmatis / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013302:Streptomyces / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; C510997:angucyclinone