Concentration of 68Ga via solvent extraction.
The metallic cation, (68)Ga (III) is suitable for complexation with chelators either naked or conjugated with biological macromolecules, however, such labeling procedure requires high chemical purity and concentrated solutions of (68)Ga (III), which cannot be sufficiently fulfilled by the presently available (68)Ge/(68)Ga generator eluate. A method to increase the concentration and purity of (68)Ga obtained from a commercial (68)Ge/(68)Ga generator has been developed. The (68)Ga eluate (1M HCl) is extracted in methyl ethyl ketone, which is evaporated and taken in a small volume of buffer.
Bokhari
Tanveer Hussain
TH
Isotope Production Division, Pakistan Institute of Nuclear Science & Technology, P.O. Nilore, Islamabad, Pakistan.
Mushtaq
A
A
Khan
Islam Ullah
IU
D002074:Butanones; D005857:Germanium / Q000302:isolation & purification*; D007553:Isotope Labeling / Q000379:methods*; D008722:Methods; D011868:Radioisotopes / Q000302:isolation & purification; D012997:Solvents
D002074:Butanones; D011868:Radioisotopes; D012997:Solvents; D005857:Germanium; C005222:methylethyl ketone