title: LRRK2 R1628P increases risk of Parkinson's disease: replication evidence.
abstract: We showed that the frequency of a LRRK2 variant (c.4883G > C, R1628P) was higher in Parkinson's disease (PD) compared to controls (8.4 vs. 3.4%, P = 0.046, OR 2.5, 95% CI 1.1-5.6). In the multivariate logistic regression (with adjustments made for the effect of age, age of onset, and gender), the heterozygous R1628P genotype was associated with an increased risk of PD compared to controls (OR 3.3, 95% CI 1.4- 7.9, P = 0.007). We provided an independent confirmation that the R1628P variant increases the risk of PD among Chinese.
authors.affiliation: Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Outram Road, Singapore, 169608, Singapore. gnrtek@sgh.com.sg
authors.forename: E K
authors.initials: EK
authors.lastname: Tan
authors.forename: Louis C
authors.initials: LC
authors.lastname: Tan
authors.forename: H Q
authors.initials: HQ
authors.lastname: Lim
authors.forename: R
authors.initials: R
authors.lastname: Li
authors.forename: M
authors.initials: M
authors.lastname: Tang
authors.forename: Yuen
authors.initials: Y
authors.lastname: Yih
authors.forename: R
authors.initials: R
authors.lastname: Pavanni
authors.forename: K M
authors.initials: KM
authors.lastname: Prakash
authors.forename: S
authors.initials: S
authors.lastname: Fook-Chong
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000208:ethnology* / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics* / Q000502:physiology*; D012306:Risk
chemical_list: C495280:LRRK2 protein, human; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D017346:Protein Serine-Threonine Kinases
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