title: Systems pathology--or how to solve the complex problem of predictive pathology.
abstract: To understand the extreme complexity of biological events requires a systemic approach. This holds particularly for the disordered biological interactions that are characteristic of disease, the subject of pathology. Which options are available to untie the Gordian knot? In this contribution, the potential role of systems biology and, as a further development, systems pathology will be discussed.
authors.affiliation: Department of Pathology, Charité-University Medicine Berlin, Charitéplatz 1, 10117, Berlin, Germany. manfred.dietel@charite.de
authors.forename: Manfred
authors.initials: M
authors.lastname: Dietel
authors.forename: Reinhold
authors.initials: R
authors.lastname: Schäfer
mesh_terms: D003933:Diagnosis; D005544:Forecasting; D017143:Fuzzy Logic; D006801:Humans; D007256:Information Systems; D008954:Models, Biological; D010338:Pathology, Clinical; D049490:Systems Biology; D014584:User-Computer Interface
references.citation: Brain Nerve. 2011 Jan;63(1):88-9
references.pmid: 21516882
references.citation: Nat Rev Drug Discov. 2005 Dec;4(12):961-7
references.pmid: 16341061
references.citation: J Pathol. 2007 Aug;212(4):353-5
references.pmid: 17573671
references.citation: Nat Clin Pract Urol. 2007 Jan;4(1):39-45
references.pmid: 17211424
references.citation: Curr Opin Biotechnol. 2008 Aug;19(4):381-8
references.pmid: 18634875
references.citation: Mol Syst Biol. 2005;1:2005.0010
references.pmid: 16729045
references.citation: Brain Nerve. 2010 Dec;62(12):1358-9
references.pmid: 21305806
references.citation: Science. 1993 Dec 24;262(5142):1953
references.pmid: 8266084