title: Synthesis and biological activity of anticoccidial agents: 5,6-diarylimidazo[2,1-b][1,3]thiazoles.
abstract: Novel 5,6-diarylimidazo[2,1-b][1,3]thiazoles bearing an amine substituent at the imidazothiazole 2-position have been synthesized and evaluated as anticoccidial agents in both in vitro and in vivo assays. Both subnanomolar in vitro activity and broad spectrum in vivo potency were detected for several compounds, particularly compound 10.
authors.affiliation: SCYNEXIS, Inc., Discovery Chemistry, PO Box 12878, Research Triangle Park, NC 27709-2878, USA. andrew.scribner@scynexis.com
authors.forename: Andrew
authors.initials: A
authors.lastname: Scribner
authors.forename: Susan
authors.initials: S
authors.lastname: Meitz
authors.forename: Michael
authors.initials: M
authors.lastname: Fisher
authors.forename: Matthew
authors.initials: M
authors.lastname: Wyvratt
authors.forename: Penny
authors.initials: P
authors.lastname: Leavitt
authors.forename: Paul
authors.initials: P
authors.lastname: Liberator
authors.forename: Anne
authors.initials: A
authors.lastname: Gurnett
authors.forename: Chris
authors.initials: C
authors.lastname: Brown
authors.forename: John
authors.initials: J
authors.lastname: Mathew
authors.forename: Donald
authors.initials: D
authors.lastname: Thompson
authors.forename: Dennis
authors.initials: D
authors.lastname: Schmatz
authors.forename: Tesfaye
authors.initials: T
authors.lastname: Biftu
mesh_terms: D000818:Animals; D003049:Coccidiostats / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D020650:Combinatorial Chemistry Techniques; D017869:Cyclic GMP-Dependent Protein Kinases / Q000037:antagonists & inhibitors; D004539:Eimeria / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D003049:Coccidiostats; D007093:Imidazoles; D047428:Protein Kinase Inhibitors; D013844:Thiazoles; D017869:Cyclic GMP-Dependent Protein Kinases