title: The role of high frequency oscillatory ventilation in the management of children with severe traumatic brain injury and concomitant lung pathology.
abstract: OBJECTIVE
  To report the use of high frequency oscillatory ventilation (HFOV) in two children with severe traumatic brain injury and concurrent lung pathology where conventional mechanical ventilation was ineffective.
  
  
  METHODS
  : Case report.
  
  
  METHODS
  Regional intensive care unit in a pediatric teaching hospital.
  
  
  METHODS
  Two severely head-injured children (both with postresuscitation Glasgow Coma Scores of 3), one of whom was age 11 yrs and developed an invasive fungal (rhizomucor) pneumonia, while the other age 5 yrs had bilateral lung contusions. Both were treated according to local head injury guidelines, which included conventional ventilation. Despite increasing conventional ventilatory support, CO2 removal became problematic in both cases, making the intracranial pressure control and consequent maintenance of adequate cerebral perfusion pressure difficult. In both patients, a dramatic reduction in intracranial pressure and improvement in cerebral perfusion pressure was observed soon after the use of HFOV. Additionally, inotropic support was weaned by 50% in both children after commencing HFOV. A significant increase in the mean arterial blood pressure occurred in one child with HFOV.
  
  
  METHODS
  Use of HFOV as an alternative to conventional mechanical ventilation.
  
  
  CONCLUSIONS
  HFOV may have utility in the management of selected cases of severe brain trauma with concurrent lung pathology where conventional ventilation is ineffective.
authors.affiliation: Department of Child Life & Health, University of Edinburgh, Royal Hospital for Sick Children of Edinburgh, Edinburgh, UK.
authors.forename: Tsz-Yan M
authors.initials: TY
authors.lastname: Lo
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Jones
authors.forename: Julie A
authors.initials: JA
authors.lastname: Freeman
authors.forename: Jillian
authors.initials: J
authors.lastname: McFadzean
authors.forename: Robert A
authors.initials: RA
authors.lastname: Minns
mesh_terms: D001930:Brain Injuries / Q000503:physiopathology; D002648:Child; D006612:High-Frequency Ventilation; D006784:Hospitals, Teaching; D006801:Humans; D008168:Lung / Q000473:pathology*; D008297:Male; D015599:Trauma Severity Indices