Pro12Ala polymorphism in PPAR gamma 2 associated with essential hypertension in Chinese nonagenarians/centenarians.
The Pro12Ala polymorphism of PPAR gamma 2 has been shown to influence hypertension and the benefit of longevity in previous studies. We examined whether the polymorphism was related to essential hypertension among long-lived subjects (is greater than 90 years). The Pro12Ala variant was examined using polymerase chain reaction restriction fragment length polymorphism in a population-based sample of 839 long-lived subjects (mean 94 years SD 4 years, aged 90-108 years). The genotype frequencies of the Pro12Ala polymorphism were 0.2% Ala12Ala, 9.4% Pro12Ala and 90.4% Pro12Pro in all participants. The frequency of the Ala12 allele was 3.45% in the hypertension group and 6.92% among the normotension group (P=0.001). Moreover, in the total study population, Ala12 allele carriers had lower levels of triglycerides (1.03+/-0.5 mmol/L (means+/-SD) vs. 1.25+/-0.61 mmol/L; P<0.001). In conclusion, these results suggest that the Pro12Ala polymorphism of the PPAR gamma 2 gene is associated with hypertension and triglycerides levels in Chinese nonagenarians/centenarians.
Lu
Zhenchan
Z
Department of Geriatrics, West China Hospital, West China Medical School, Sichuan University, No. 37 Guoxue Xiang, Ren Min Nan Lu, Chengdu, Sichuan Province 610041, China.
Dong
Birong
B
Mo
Xianming
X
Chen
Tie
T
Wu
Hongmei
H
Zhang
Yanling
Y
Xiao
Hengyi
H
D000369:Aged, 80 and over; D000483:Alleles; D044466:Asian People; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D047495:PPAR gamma / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors; D014280:Triglycerides / Q000235:genetics*
D047495:PPAR gamma; D014280:Triglycerides