Influence of phosphorohydrazone derivatives of benzopyrones on polymerization and viscosity of fibrin.
The synthesis and antitumour and antibacterial activity of coumarin and chromone phosphorohydrazones have been reported. This study describes influence of phosphorohydrazones derivatives of coumarin and chromone on the polymerization and viscosity of fibrin. The fibrin polymerization assay was performed by the Shen and Lorand method and the clot viscosity was measured on the basis of Shen and Lorand and Marchi and coworkers methods. Among the eight compounds tested, one coumarin derivative and two chromone derivatives showed significant activity.
Michalska
Marta
M
Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Medical University of Łódź, Łódź, Poland.
Pajak
Wojciech
W
Kołodziejska
Justyna
J
Lazarenkow
Andrzej
A
Nawrot-Modranka
Jolanta
J
D001704:Biopolymers / Q000737:chemistry; D002867:Chromones / Q000737:chemistry / Q000494:pharmacology*; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology*; D005337:Fibrin / Q000737:chemistry* / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D015394:Molecular Structure; D013056:Spectrophotometry, Ultraviolet; D014783:Viscosity / Q000187:drug effects
D001704:Biopolymers; D002867:Chromones; D003374:Coumarins; D005337:Fibrin