A brief educational intervention may increase public acceptance of emergency research without consent.
OBJECTIVE
We hypothesized that knowing the regulations regarding emergency research without consent would increase public support for this type of research.


METHODS
Randomized controlled trial. Consecutive patients presenting during eight 24-h periods received one of two interviews; the intervention interview included an educational paragraph.


RESULTS
There were 473 (74% of eligible) patients who participated: 51% (95% confidence interval [CI] 46-55) were willing to be enrolled in a study using exception to informed consent; 84% (95% CI 80-87) believed that current therapy for cardiac arrest offers ≥ 50% chance of full recovery, and these patients were less willing to enroll (odds ratio [OR] 0.5, 95% CI 0.3-0.9). The educational intervention increased willingness to enroll (OR 1.3, 95% CI 1.0-1.6, p = 0.03).


CONCLUSIONS
A brief educational intervention had only a modest effect on willingness to participate in emergency research without consent. It may be more important to educate patients on the shortcomings of current therapy than on the ethical and regulatory justifications for such research.
Goldstein
Joshua N
JN
Department of Emergency Medicine, Brigham & Women's Hospital, Boston, Massachusetts, USA.
Delaney
Kate E
KE
Pelletier
Andrea J
AJ
Fisher
Jonathan
J
Blanc
Phillip G
PG
Halsey
Mark
M
Pallin
Daniel J
DJ
Camargo
Carlos A
CA
D035843:Biomedical Research; D001900:Boston; D016009:Chi-Square Distribution; D016001:Confidence Intervals; D003710:Demography; D004636:Emergency Service, Hospital; D004638:Emergency Treatment; D005260:Female; D006801:Humans; D007258:Informed Consent; D007407:Interviews as Topic; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010353:Patient Education as Topic; D011639:Public Opinion; D011795:Surveys and Questionnaires