Patterns of molecular evolution associated with two selective sweeps in the Tb1-Dwarf8 region in maize.
We focused on a region encompassing a major maize domestication locus, Tb1, and a locus involved in the flowering time variation, Dwarf8 (D8), to investigate the consequences of two closely linked selective sweeps on nucleotide variation and gain some insights into maize geographical diffusion, through climate adaptation. First, we physically mapped D8 at approximately 300 kb 3' of Tb1. Second, we analyzed patterns of nucleotide variation at Tb1, D8, and seven short regions (400-700 bp) located in the Tb1-D8 region sequenced on a 40 maize inbred lines panel encompassing early-flowering temperate and late-flowering tropical lines. The pattern of polymorphism along the region is characterized by two valleys of depleted polymorphism while the region in between exhibits an appreciable amount of diversity. Our results reveal that a region approximately 100 kb upstream of the D8 gene exhibits hallmarks of divergent selection between temperate and tropical lines and is likely closer than the D8 gene to the target of selection for climate adaptation. Selection in the tropical lines appears more recent than in the temperate lines, suggesting an initial domestication of early-flowering maize. Simulation results indicate that the polymorphism pattern is consistent with two interfering selective sweeps at Tb1 and D8.
Camus-Kulandaivelu
Letizia
L
INRA, UMR 0320/UMR 8120 Genetique Vegetale, F-91190 Gif-sur-Yvette, France.
Chevin
Luis-Miguel
LM
Tollon-Cordet
Christine
C
Charcosset
Alain
A
Manicacci
Domenica
D
Tenaillon
Maud I
MI
D002980:Climate; D019143:Evolution, Molecular; D017343:Genes, Plant; D014644:Genetic Variation; D018745:Genome, Plant; D010940:Plant Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D013997:Time Factors; D003313:Zea mays / Q000235:genetics*
C120414:D8 protein, Zea mays; D010940:Plant Proteins; C105292:TB1 protein, Zea mays
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