title: Chemical models and their mechanistic implications for the transformation of 6-cyanouridine 5'-monophosphate catalyzed by orotidine 5'-monophosphate decarboxylase.
abstract: Orotidine 5'-monophosphate decarboxylase (ODCase) catalyzes an unprecedented transformation of 6- cyanouridine 5'-monophosphate (6-CN-UMP) into barbiturate nucleoside 5'-monophosphate (6-hydroxyuridine 5'-monophosphate, BMP). The reactions of 6- cyano-1,3-dimethyluracil toward various nucleophilic conditions have been studied as chemical models in order to understand the possible mechanism for the ODCase-catalyzed transformation of 6-CN-UMP.
authors.affiliation: Department of Chemistry, College of Science, National Taiwan Normal University, Taipei 11677, Taiwan. tcchien@ntnu.edu.tw
authors.forename: Tun-Cheng
authors.initials: TC
authors.lastname: Chien
authors.forename: Cheng-Hung
authors.initials: CH
authors.lastname: Jen
authors.forename: Yuen-Jen
authors.initials: YJ
authors.lastname: Wu
authors.forename: Chen-Chieh
authors.initials: CC
authors.lastname: Liao
mesh_terms: D001463:Barbiturates / Q000737:chemistry; D002384:Catalysis; D008956:Models, Chemical; D009964:Orotidine-5'-Phosphate Decarboxylase / Q000737:chemistry* / Q000378:metabolism; D014542:Uridine Monophosphate / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism
chemical_list: C513367:6-cyanouridine 5'-O-monophosphate; C541623:6-hydroxyuridine 5'-monophosphate; D001463:Barbiturates; D014542:Uridine Monophosphate; D009964:Orotidine-5'-Phosphate Decarboxylase