title: Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells.
abstract: Little is known about the functional differences between the human skin myeloid dendritic cell (DC) subsets, epidermal CD207(+) Langerhans cells (LCs) and dermal CD14(+) DCs. We showed that CD14(+) DCs primed CD4(+) T cells into cells that induce naive B cells to switch isotype and become plasma cells. In contrast, LCs preferentially induced the differentiation of CD4(+) T cells secreting T helper 2 (Th2) cell cytokines and were efficient at priming and crosspriming naive CD8(+) T cells. A third DC population, CD14(-)CD207(-)CD1a(+) DC, which resides in the dermis, could activate CD8(+) T cells better than CD14(+) DCs but less efficiently than LCs. Thus, the human skin displays three DC subsets, two of which, i.e., CD14(+) DCs and LCs, display functional specializations, the preferential activation of humoral and cellular immunity, respectively.
authors.affiliation: Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX 75204, USA.
authors.forename: Eynav
authors.initials: E
authors.lastname: Klechevsky
authors.forename: Rimpei
authors.initials: R
authors.lastname: Morita
authors.forename: Maochang
authors.initials: M
authors.lastname: Liu
authors.forename: Yanying
authors.initials: Y
authors.lastname: Cao
authors.forename: Sebastien
authors.initials: S
authors.lastname: Coquery
authors.forename: Luann
authors.initials: L
authors.lastname: Thompson-Snipes
authors.forename: Francine
authors.initials: F
authors.lastname: Briere
authors.forename: Damien
authors.initials: D
authors.lastname: Chaussabel
authors.forename: Gerard
authors.initials: G
authors.lastname: Zurawski
authors.forename: A Karolina
authors.initials: AK
authors.lastname: Palucka
authors.forename: Yoram
authors.initials: Y
authors.lastname: Reiter
authors.forename: Jacques
authors.initials: J
authors.lastname: Banchereau
authors.forename: Hideki
authors.initials: H
authors.lastname: Ueno
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D016207:Cytokines / Q000276:immunology / Q000378:metabolism*; D004817:Epidermis / Q000276:immunology; D053804:Granzymes / Q000378:metabolism; D006801:Humans; D007156:Immunologic Memory; D007801:Langerhans Cells / Q000276:immunology* / Q000378:metabolism; D018950:Lipopolysaccharide Receptors / Q000276:immunology; D008213:Lymphocyte Activation; D012867:Skin / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
chemical_list: D016207:Cytokines; D018950:Lipopolysaccharide Receptors; D053804:Granzymes
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