title: Double primary malignancy in colorectal cancer patients--MSI is the useful marker for predicting double primary tumors.
abstract: OBJECTIVE
  The incidence of double primary malignancies (DPM) is known to be higher in colorectal cancer patients than the general population. And, the role of microsatellite instability (MSI) in DPM has been previously studied. We evaluated the clinical features and association between MSI and colorectal cancer patients with DPM.
  
  
  METHODS
  From September 1994 to May 2004, we reviewed 2,301 colorectal cancer patients with regard to secondary primary malignancies. A subgroup analysis was performed for MSI after January 2003.
  
  
  RESULTS
  One hundred forty-five patients (6.3%) had a DPM identified. In DPM group, 57 patients had a synchronous DPM (39.3%), and 88 patients had a metachronous malignancy (60.7%). Male gender (p<0.001) and colon cancer (p<0.001) were the factors related with the development of the DPM. Most of the second malignancies occurred within 3 years after the primary operation. The common second malignancies were stomach (58 patients, 40%) and lung (21 patients, 14.5%). In the subgroup analysis, there was a higher frequency of DPM in the MSI group when compared to the microsatellite stable group (p=0.021).
  
  
  CONCLUSIONS
  The careful pre- and postoperative evaluation should be paid for detecting DPM as well as for detecting recurrence in colorectal cancer patients. The results of this study suggest that MSI might be a useful marker for the detection of DPM in colorectal cancer patients.
authors.affiliation: Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Ilwon-dong 50, Gangnam-gu, Seoul 135-710, South Korea.
authors.forename: H R
authors.initials: HR
authors.lastname: Yun
authors.forename: L J
authors.initials: LJ
authors.lastname: Yi
authors.forename: Y K
authors.initials: YK
authors.lastname: Cho
authors.forename: J H
authors.initials: JH
authors.lastname: Park
authors.forename: Y B
authors.initials: YB
authors.lastname: Cho
authors.forename: S H
authors.initials: SH
authors.lastname: Yun
authors.forename: H C
authors.initials: HC
authors.lastname: Kim
authors.forename: H K
authors.initials: HK
authors.lastname: Chun
authors.forename: W Y
authors.initials: WY
authors.lastname: Lee
mesh_terms: D015179:Colorectal Neoplasms / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D053842:Microsatellite Instability; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000235:genetics*; D013274:Stomach Neoplasms / Q000556:secondary; D016019:Survival Analysis; D013997:Time Factors
chemical_list: D005819:Genetic Markers
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