title: The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone.
abstract: The embryonic subventricular zone (SVZ) is a critical site for generating cortical projection neurons; however, molecular mechanisms regulating neurogenesis specifically in the SVZ are largely unknown. The transcription factor Eomes/Tbr2 is transiently expressed in cortical SVZ progenitor cells. Here we demonstrate that conditional inactivation of Tbr2 during early brain development causes microcephaly and severe behavioral deficits. In Tbr2 mutants the number of SVZ progenitor cells is reduced and the differentiation of upper cortical layer neurons is disturbed. Neurogenesis in the adult dentate gyrus but not the subependymal zone is abolished. These studies establish Tbr2 as a key regulator of neurogenesis in the SVZ.
authors.affiliation: Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom.
authors.forename: Sebastian J
authors.initials: SJ
authors.lastname: Arnold
authors.forename: Guo-Jen
authors.initials: GJ
authors.lastname: Huang
authors.forename: Amanda F P
authors.initials: AF
authors.lastname: Cheung
authors.forename: Takumi
authors.initials: T
authors.lastname: Era
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Nishikawa
authors.forename: Elizabeth K
authors.initials: EK
authors.lastname: Bikoff
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Molnár
authors.forename: Elizabeth J
authors.initials: EJ
authors.lastname: Robertson
authors.forename: Matthias
authors.initials: M
authors.lastname: Groszer
mesh_terms: D000818:Animals; D002552:Cerebral Ventricles / Q000166:cytology* / Q000196:embryology; D051379:Mice; D009474:Neurons / Q000166:cytology*; D020825:T-Box Domain Proteins / Q000502:physiology*
chemical_list: C491198:Eomes protein, mouse; D020825:T-Box Domain Proteins
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