title: Hetero-expanded purine nucleosides. Design, synthesis and preliminary biological activity.
abstract: Several thieno-expanded purine nucleoside analogues were synthesized for use as tools in ongoing investigations into nucleic acid structure and function in our laboratories. The inclusion of the thiophene ring system in the nucleoside endows the purine scaffold with advantages not previously available in other reported expanded purines. The synthesis and preliminary biological studies are reported herein.
authors.affiliation: University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA. kseley@umbc.edu
authors.forename: Katherine L
authors.initials: KL
authors.lastname: Seley-Radtke
authors.forename: Zhibo
authors.initials: Z
authors.lastname: Zhang
authors.forename: Orrette R
authors.initials: OR
authors.lastname: Wauchope
authors.forename: Sarah C
authors.initials: SC
authors.lastname: Zimmermann
authors.forename: Alexander
authors.initials: A
authors.lastname: Ivanov
authors.forename: Brent
authors.initials: B
authors.lastname: Korba
mesh_terms: D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011684:Purine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012324:RNA-Dependent RNA Polymerase / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D011684:Purine Nucleosides; D012324:RNA-Dependent RNA Polymerase
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