title: Community perspectives on the ethical issues surrounding adolescent HIV vaccine trials in South Africa.
abstract: Adolescents globally are at high risk for HIV acquisition and are the targets of HIV prevention interventions such as HIV vaccines. In order to understand stakeholders' attitudes towards the ethical issues of adolescent involvement in HIV vaccine trials, we conducted focus group discussions with key members of a semi-urban, informal Cape Town community with high HIV prevalence in which HIV vaccine trials are taking place. Themes were identified from focus group transcripts by four researchers, and included necessity of guardian consent, age of independent consent, and confidentiality of in-trial medical results. In general, ethical adolescent HIV vaccine trials will be feasible in this community.
authors.affiliation: Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa. hbjaspan@hotmail.com
authors.forename: Heather B
authors.initials: HB
authors.lastname: Jaspan
authors.forename: Nosiphiwo F
authors.initials: NF
authors.lastname: Soka
authors.forename: Ann E
authors.initials: AE
authors.lastname: Strode
authors.forename: Catherine
authors.initials: C
authors.lastname: Mathews
authors.forename: Daniella
authors.initials: D
authors.lastname: Mark
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Flisher
authors.forename: Robin
authors.initials: R
authors.lastname: Wood
authors.forename: Linda-Gail
authors.initials: LG
authors.lastname: Bekker
mesh_terms: D016915:AIDS Vaccines / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D001294:Attitude to Health; D026688:Bioethical Issues; D002986:Clinical Trials as Topic; D003159:Community-Institutional Relations; D003219:Confidentiality; D005260:Female; D017144:Focus Groups; D006801:Humans; D007258:Informed Consent; D008297:Male; D018579:Patient Selection; D035842:Research Subjects / Q000523:psychology; D013019:South Africa; D055815:Young Adult
chemical_list: D016915:AIDS Vaccines
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