Correlation between IL-10 gene expression and HPV infection in cervical cancer: a mechanism for immune response escape.
The present study was performed to determine IL-10 expression in cervical tissues in Mexican women according to the severity of the malignity and its association with HPV infection. IL-10 expression showed a clear tendency to increase during the different cervical cancer stages: 37% in LGSIL; 62% in HGSIL; and 84% in cancer. However, all the patients that expressed IL-10 were HPV positives; we found an association with HPV 16. These results suggest a clear relationship between IL-10, HPV and the stage of cervical cancer disease; this event could contribute to the immunosuppressive micro-environment in the tumor site.
Bermudez-Morales
Victor H
VH
Division of Molecular Biology of Pathogens, National Institute of Public Health, Morelos, Mexico.
Gutierrez
Lourdes X
LX
Alcocer-Gonzalez
Juan M
JM
Burguete
Ana
A
Madrid-Marina
Vicente
V
D017931:DNA Primers; D004273:DNA, Neoplasm / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008800:Mexico; D009367:Neoplasm Staging; D030361:Papillomavirus Infections / Q000150:complications* / Q000453:epidemiology / Q000276:immunology*; D015995:Prevalence; D012333:RNA, Messenger / Q000235:genetics; D012334:RNA, Neoplasm / Q000235:genetics / Q000302:isolation & purification; D020133:Reverse Transcriptase Polymerase Chain Reaction; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000235:genetics* / Q000276:immunology / Q000473:pathology*
D017931:DNA Primers; D004273:DNA, Neoplasm; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D016753:Interleukin-10