Extract from Acanthopanax senticosus harms (Siberian ginseng) activates NTS and SON/PVN in the rat brain.
The extract of the stem bark of Siberian ginseng, Acanthopanax senticosus Harms (ASH), is believed to play a body-coping role in stress through a brain noradrenergic mechanism. The present study was carried out to investigate the effect of ASH on the neuronal activation patterns of c-Fos expression in the rat brain. With ASH administration, c-Fos accumulated in both the supraoptic nuclei (SON) and paraventricular nuclei (PVN), which regulate stress response. Only the caudal regions in the nucleus of the solitary tract (NTS), a locus innervating both the SON and PVN, were activated. Such a neuro-anatomical pattern associated with ASH suggests the possible involvement of these stress-related brain loci.
Soya
Hideaki
H
Laboratory of Exercise Biochemistry, University of Tsukuba Graduate School of Comprehensive Human Sciences, Tsukuba, Japan. hsoya@taiiku.tsukuba.ac.jp
Deocaris
Custer C
CC
Yamaguchi
Kaoru
K
Ohiwa
Nao
N
Saito
Tsuyoshi
T
Nishijima
Takeshi
T
Kato
Morimasa
M
Tateoka
Masaru
M
Matsui
Takashi
T
Okamoto
Masahiro
M
Fujikawa
Takahiko
T
D000818:Animals; D001921:Brain / Q000378:metabolism*; D028001:Eleutherococcus / Q000235:genetics / Q000378:metabolism*; D008297:Male; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects* / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017552:Solitary Nucleus / Q000378:metabolism*; D013495:Supraoptic Nucleus / Q000187:drug effects* / Q000378:metabolism
D010936:Plant Extracts