Synthesis and antiviral evaluation of a seven-membered sugar ring nucleoside analog, 9-(5-deoxy-beta-D-allo-septanosyl)-adenine.
The first example of a nucleoside analogue bearing a 5'-deoxy-beta-D-allo-septanose as the sugar moiety was synthesized and evaluated as a potential inhibitor of several virus replication.
Sizun
Gwenaëlle
G
Idenix Pharmaceuticals: Medicinal Chemistry Laboratory, Cap Gamma, 1682 Rue de la Valsière, 34189 Montpellier Cedex 4, France.
Griffon
Jean-François
JF
Griffe
Ludovic
L
Dukhan
David
D
Storer
Richard
R
Sommadossi
Jean-Pierre
JP
Loi
Anna Giulia
AG
Musiu
Chiara
C
Poddesu
Barbara
B
Cadeddu
Alessandra
A
Fanti
Maura
M
Boscu
Nadia
N
Bassetti
Fabiola
F
Liuzzi
Michel
M
Gosselin
Gilles
G
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
C541635:9-(5-deoxyseptanosyl)adenine; D000998:Antiviral Agents; D000241:Adenosine