title: Synthesis and properties of covalently linked antiparallel and parallel DNA duplexes.
abstract: We synthesized covalently linked antiparallel stranded (aps) and parallel stranded (ps) DNA duplexes. These modified duplexes contained an ethylene-linked T-T base pair at the duplex end. Thermal denaturation analysis of these modified duplexes indicated that the aps and ps DNA duplexes have similar thermal stabilities.
authors.affiliation: Department of Material and Life Chemistry, Faculty of Engineering, Kanagawa University, Yokohama, Kanagawa 221-8686, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Ono
authors.forename: Yuko
authors.initials: Y
authors.lastname: Saotome
authors.forename: Itaru
authors.initials: I
authors.lastname: Okamoto
authors.forename: Akira
authors.initials: A
authors.lastname: Ono
mesh_terms: D004247:DNA / Q000138:chemical synthesis* / Q000737:chemistry; D009691:Nucleic Acid Denaturation; D009943:Organophosphorus Compounds / Q000737:chemistry; D013696:Temperature; D013941:Thymine / Q000737:chemistry
chemical_list: D009943:Organophosphorus Compounds; C434331:phosphoramidite; D004247:DNA; D013941:Thymine