IL17 and IFNgamma production by peripheral blood mononuclear cells from clinically isolated syndrome to secondary progressive multiple sclerosis.
We evaluated the spontaneous IL17, IFNgamma and IL10 production by peripheral blood mononuclear cells from patients affected by clinically isolated syndromes (CIS) suggestive of multiple sclerosis (MS) both in acute phase and in remission, relapsing remitting MS (RRMS) both in relapse and in remission, not-relapsing secondary progressive MS (SPMS) and controls. We observed higher IL17 levels in CIS patients both in acute phase and in remission than in SPMS patients and controls. On the contrary no difference in IL17 production was observed among RRMS patients and CIS, SPMS patients and controls. IFNgamma levels were significantly higher in CIS patients in acute phase than in CIS and RRMS patients in remission, SPMS patients and controls. Moreover, we observed higher IFNgamma spontaneous production in relapsing RRMS patients than in remitting RRMS and SPMS patients and controls. IL10 levels were significantly higher in remitting CIS and in relapsing RRMS patients than in SPMS patients and controls. There was no difference in IFNgamma, IL10 and IL17 levels between SPMS patients and controls. Our data suggest that IL17 might play a crucial role mainly in the early phase of MS, while IFNgamma seems to be involved both in the early phase and in the following relapses of the disease.
Frisullo
Giovanni
G
Institute of Neurology, Department of Neuroscience, Catholic University, Largo Agostino Gemelli 8, 00168 Rome, Italy.
Nociti
Viviana
V
Iorio
Raffaele
R
Patanella
Agata Katia
AK
Marti
Alessandro
A
Caggiula
Marcella
M
Mirabella
Massimiliano
M
Tonali
Pietro Attilio
PA
Batocchi
Anna Paola
AP
D000328:Adult; D003711:Demyelinating Diseases / Q000097:blood; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis*; D016753:Interleukin-10 / Q000096:biosynthesis*; D020381:Interleukin-17 / Q000096:biosynthesis*; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood*; D020528:Multiple Sclerosis, Chronic Progressive / Q000097:blood; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood
C508609:IL10 protein, human; D020381:Interleukin-17; D016753:Interleukin-10; D007371:Interferon-gamma