Antifungal cyclic depsipeptide, eujavanicin A, isolated from Eupenicillium javanicum.
In the course of searching for new antifungal agents, a new cyclic depsipeptide, eujavanicin A (1), was isolated from Eupenicillium javanicum as an antifungal agent against the human pathogenic filamentous fungus Aspergillus fumigatus. The structure of 1 was established by spectroscopic and chemical investigations. The absolute stereochemistry was elucidated by Marfey's method and by chiral HPLC analysis.
Nakadate
Shou
S
School of Pharmaceutical Sciences, Ohu University, Misumido 31-1, Tomita-machi, Koriyama, Fukushima 963-8611, Japan.
Nozawa
Koohei
K
Sato
Hiroyasu
H
Horie
Hitoshi
H
Fujii
Yuichi
Y
Nagai
Masahiro
M
Hosoe
Tomoo
T
Kawai
Ken-ichi
K
Yaguchi
Takashi
T
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects*; D001412:Bacillus subtilis / Q000187:drug effects; D047630:Depsipeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D007564:Japan; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012477:Salmonella enteritidis / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
D000935:Antifungal Agents; D047630:Depsipeptides; C532732:eujavanicin A