Actin and microtubules: working together to control spindle polarity.
Centrosomes are frequently amplified in cancer cells, but centrosome clustering pathways act to minimize their detrimental impact on mitosis. Recent data published online in Genes & Developments by Kwon et al. (2008) suggest that these pathways involve microtubule motors, actin, and focal adhesions. Since centrosomal amplification is rarely seen in normal cells, could blocking clustering lead to the selective killing of tumor cells?
Xu
Fengfeng L
FL
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Saunders
William S
WS
D000199:Actins / Q000502:physiology*; D000818:Animals; D064127:Aurora Kinases; D018385:Centrosome / Q000378:metabolism / Q000502:physiology*; D022001:Focal Adhesions / Q000502:physiology; D008870:Microtubules / Q000502:physiology*; D008938:Mitosis / Q000502:physiology; D008954:Models, Biological; D020409:Molecular Motor Proteins / Q000378:metabolism / Q000502:physiology; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D008941:Spindle Apparatus / Q000502:physiology*
D000199:Actins; D020409:Molecular Motor Proteins; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases