title: Multifocal VEP and OCT in optic neuritis: a topographical study of the structure-function relationship.
abstract: OBJECTIVE
  To investigate topographical relationship between amplitude of multifocal visual evoked potentials (mfVEP) and retinal nerve fibre layer (RNFL) thickness following acute optic neuritis (ON).
  
  
  METHODS
  Fifty patients with a clinical diagnosis of acute unilateral ON between 6 and 36 months prior to the study and 25 age-matched controls underwent mfVEP testing (Accumap V 2.1, ObjectiVision Pty Ltd, Sydney, Australia) and OCT imaging (fast RNFL protocol, Stratus, software version 3.0, Carl Zeiss Meditec, Inc., Dublin, CA). RNFL thickness and mfVEP amplitude were measured for upper, temporal and lower retinal sectors and corresponding areas of the visual field in affected eyes of ON patients and control eyes. Inter-eye asymmetry coefficients for both RNFL thickness and mfVEP amplitude were calculated for each zone, and corresponding coefficients were correlated between each other.
  
  
  RESULTS
  There was highly significant reduction of RNFL thickness and mean mfVEP amplitude in all three retinal sectors of the affected eye. Largest reduction of RNFL thickness was noticed in temporal sector and of mfVEP amplitude in corresponding central part of the visual field. RNFL thickness correlated highly with amplitude of the mfVEP derived from corresponding areas of the visual field in all three zones.
  
  
  CONCLUSIONS
  We demonstrated strong topographical associations between structural and functional measures of optic nerve integrity in patients with ON.
authors.affiliation: Department of Ophthalmology, Save Sight Institute, University of Sydney, P.O. Box 4337, Sydney, NSW 2001, Australia. sasha@eye.usyd.edu.au
authors.forename: Alexander
authors.initials: A
authors.lastname: Klistorner
authors.forename: H
authors.initials: H
authors.lastname: Arvind
authors.forename: T
authors.initials: T
authors.lastname: Nguyen
authors.forename: R
authors.initials: R
authors.lastname: Garrick
authors.forename: M
authors.initials: M
authors.lastname: Paine
authors.forename: S
authors.initials: S
authors.lastname: Graham
authors.forename: J
authors.initials: J
authors.lastname: O'Day
authors.forename: C
authors.initials: C
authors.lastname: Yiannikas
mesh_terms: D000328:Adult; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology / Q000502:physiology; D009900:Optic Nerve / Q000473:pathology / Q000503:physiopathology; D009902:Optic Neuritis / Q000473:pathology / Q000503:physiopathology; D055351:Retinal Neurons / Q000473:pathology / Q000502:physiology; D041623:Tomography, Optical Coherence; D014794:Visual Fields / Q000502:physiology
references.citation: Invest Ophthalmol Vis Sci. 2007 Oct;48(10):4549-56
references.pmid: 17898277
references.citation: Arch Neurol. 2006 Jun;63(6):847-50
references.pmid: 16769865
references.citation: Retina. 1994;14(5):445-51
references.pmid: 7899721
references.citation: Electroencephalogr Clin Neurophysiol. 1983 Apr;55(4):427-35
references.pmid: 6187536
references.citation: Arch Ophthalmol. 2003 Jul;121(7):944-9
references.pmid: 12860795
references.citation: Ann Neurol. 2005 Feb;57(2):210-5
references.pmid: 15668965
references.citation: Doc Ophthalmol. 2008 Jan;116(1):19-27
references.pmid: 17680288
references.citation: Brain. 2008 Jan;131(Pt 1):277-87
references.pmid: 18056739
references.citation: J Neurol. 1999 Sep;246(9):770-5
references.pmid: 10525973
references.citation: Ophthalmology. 2001 May;108(5):905-12
references.pmid: 11320021
references.citation: Am J Pathol. 2000 Jul;157(1):267-76
references.pmid: 10880396
references.citation: Neurology. 2007 May 1;68(18):1488-94
references.pmid: 17470751
references.citation: Brain. 2004 Nov;127(Pt 11):2498-505
references.pmid: 15342363
references.citation: Invest Ophthalmol Vis Sci. 2001 Aug;42(9):2145-52
references.pmid: 11481284
references.citation: Ophthalmology. 2000 Dec;107(12):2283-99
references.pmid: 11097611
references.citation: Doc Ophthalmol. 2005 Nov;111(3):159-67
references.pmid: 16523233
references.citation: Ophthalmology. 2006 Feb;113(2):323.e1-323.e2
references.pmid: 16406544
references.citation: Arch Ophthalmol. 2005 Jun;123(6):729-39
references.pmid: 15955974
references.citation: N Engl J Med. 1998 Jan 29;338(5):278-85
references.pmid: 9445407
references.citation: Ann Neurol. 2005 Sep;58(3):383-91
references.pmid: 16075460
references.citation: J Glaucoma. 2006 Apr;15(2):110-6
references.pmid: 16633223
references.citation: Prog Retin Eye Res. 2000 Sep;19(5):607-46
references.pmid: 10925245
references.citation: Brain. 1991 Dec;114 ( Pt 6):2437-50
references.pmid: 1782525
references.citation: Doc Ophthalmol. 2004 Sep;109(2):189-99
references.pmid: 15881265
references.citation: Ophthalmology. 2000 Oct;107(10):1809-15
references.pmid: 11013178
references.citation: Invest Ophthalmol Vis Sci. 2000 May;41(6):1580-7
references.pmid: 10798679
references.citation: J Neurol Sci. 2007 Dec 15;263(1-2):3-14
references.pmid: 17673257
references.citation: Ann Neurol. 2005 Jun;57(6):904-13
references.pmid: 15929047
references.citation: Ann Neurol. 2001 Jul;50(1):121-7
references.pmid: 11456302
references.citation: Ann Neurol. 2005 May;57(5):622-33
references.pmid: 15852380
references.citation: Invest Ophthalmol Vis Sci. 1999 Oct;40(11):2520-7
references.pmid: 10509645
references.citation: Curr Opin Ophthalmol. 2005 Dec;16(6):346-50
references.pmid: 16264344
references.citation: Eur J Neurol. 2007 Aug;14(8):841-9
references.pmid: 17662003
references.citation: Invest Ophthalmol Vis Sci. 2005 Jul;46(7):2440-3
references.pmid: 15980233
references.citation: Br J Ophthalmol. 2003 Jul;87(7):899-901
references.pmid: 12812895
references.citation: Am J Ophthalmol. 2002 Jan;133(1):29-39
references.pmid: 11755837
references.citation: Brain. 2005 Nov;128(Pt 11):2705-12
references.pmid: 16230320
references.citation: Curr Opin Ophthalmol. 1999 Apr;10(2):140-6
references.pmid: 10537765
references.citation: J Neurol. 2005 Nov;252 Suppl 5:v16-24
references.pmid: 16254697
references.citation: Neuroimage. 2006 May 15;31(1):286-93
references.pmid: 16446103
references.citation: J Glaucoma. 2000 Feb;9(1):10-9
references.pmid: 10708226
references.citation: Invest Ophthalmol Vis Sci. 1998 May;39(6):937-50
references.pmid: 9579473
references.citation: Brain. 2001 Sep;124(Pt 9):1813-20
references.pmid: 11522583
references.citation: Arch Neurol. 2008 Jan;65(1):26-35
references.pmid: 18195137
references.citation: Acta Ophthalmol Scand. 2006 Dec;84(6):790-4
references.pmid: 17083540
references.citation: Ophthalmology. 2006 Feb;113(2):324-32
references.pmid: 16406539
references.citation: Electroencephalogr Clin Neurophysiol. 1994 Jan;90(1):65-81
references.pmid: 7509275
references.citation: Neurology. 1995 Feb;45(2):244-50
references.pmid: 7854520
references.citation: J Neurol Sci. 2003 Feb 15;206(2):193-8
references.pmid: 12559510
references.citation: J Physiol. 1961 Dec;159:203-21
references.pmid: 13883391
references.citation: Curr Neurol Neurosci Rep. 2007 May;7(3):239-44
references.pmid: 17488590
references.citation: Invest Ophthalmol Vis Sci. 2000 Nov;41(12):4032-8
references.pmid: 11053309
references.citation: Ann Neurol. 2006 Jun;59(6):963-9
references.pmid: 16718705
references.citation: Invest Ophthalmol Vis Sci. 1977 Sep;16(9):841-9
references.pmid: 408291
references.citation: Aust N Z J Ophthalmol. 1998 May;26 Suppl 1:S91-4
references.pmid: 9685035
references.citation: Invest Ophthalmol Vis Sci. 2004 Feb;45(2):492-8
references.pmid: 14744890