Design, synthesis, and biological evaluation of new mitonafide derivatives as potential antitumor drugs.
A series of potential DNA-binding antitumor agents, 2-[omega-(alkylamino)alkyl]-6-{[omega-(alkylamino)alkyl]amino}-1H-benzo[de]isoquinolin-1,3(2H)-diones and 1,7-bis{6-[(omega-(dimethylamino)alkyl)amino]-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl}-4-methyl-4-azaheptanes, have been prepared as mitonafide derivatives. Their DNA-binding ability and cytotoxic activity have been evaluated. Some of the target compounds have shown high DNA affinity as well as relevant cytotoxic properties.
Antonini
Ippolito
I
Department of Chemical Sciences, University of Camerino, Via S. Agostino 1, 62032 Camerino, Italy. ippolito.antonini@unicam.it
Volpini
Rosaria
R
Dal Ben
Diego
D
Lambertucci
Catia
C
Cristalli
Gloria
G
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001372:Aza Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D003110:Colonic Neoplasms / Q000378:metabolism / Q000473:pathology; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D015195:Drug Design; D019073:HT29 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D007364:Intercalating Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D007546:Isoquinolines / Q000138:chemical synthesis / Q000494:pharmacology*; D053644:Naphthalimides / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D001372:Aza Compounds; D007364:Intercalating Agents; D007546:Isoquinolines; D053644:Naphthalimides; C019215:mitonafide; D004247:DNA