title: [Levels of environmental endocrine disruptors in umbilical cord blood and maternal blood of low-birth-weight infants].
abstract: OBJECTIVE
  To monitor the biological levels of environmental endocrine disruptors (EDs, phthalates and surfactants) in the umbilical cord blood and maternal blood of low-birth-weight infants.
  
  
  METHODS
  All 30 umbilical cord blood samples and 21 maternal blood samples were collected from low-birth-weight infants. The concentration of four kinds of phthalates (di-2-ethylhexyl phthalate, DEHP; mono-2-ethylhexyl phthalate, MEHP; di-ethyl phthalate, DEP; di-n-butyl phthalate, DBP) and two kinds of surfactants (4-nonylphenol, 4-NP; octylphenol, OP) in these blood samples were measured by using reversed-phase high performance liquid chromatography.
  
  
  RESULTS
  The mean birth weight and birth length of low-birth-weight infants were (2158.48 +/- 125.06) g and (45.36 +/- 2.52) cm, respectively. The concentrations of DEP, MEHP, DBP, DEHP, 4-NP and OP were 18.90, 11.87, 7.67, 8.84, 1.51 and 2. 86 mg/L in maternal blood, and the detective rates were 86.7%, 63.3%, 60.0%, 63.3%, 56.7% and 66.7%, respectively. In umbilical cord blood, the concentrations of those EDs were 11.92, 9.94, 5.71, 5.20, 1.12 and 1.19 mg/L; the detective rates were 86.7%, 63.3%, 60.0%, 63.3%, 56.7% and 66.7%. No matter in maternal blood or in umbilical cord blood, the contents and detective rates of phthalates were higher than the surfactants. The concentration of MEHP was higher than its primer, DEHP. The contents of the target EDs in umbilical cord blood were less than those in the matched maternal blood. The percentages were 47.82% -84.05%.
  
  
  CONCLUSIONS
  People could be exposed to EDs from embryo period. And this should be paid attention by the related departments.
authors.affiliation: Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Lin
authors.forename: Li-Xing
authors.initials: LX
authors.lastname: Zheng
authors.forename: Yue-Ping
authors.initials: YP
authors.lastname: Gu
authors.forename: Jie-Yun
authors.initials: JY
authors.lastname: Wang
authors.forename: Yun-Hui
authors.initials: YH
authors.lastname: Zhang
authors.forename: Wei-Min
authors.initials: WM
authors.lastname: Song
mesh_terms: D004051:Diethylhexyl Phthalate / Q000097:blood*; D052244:Endocrine Disruptors / Q000097:blood*; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007223:Infant; D007230:Infant, Low Birth Weight / Q000097:blood*; D007231:Infant, Newborn; D009035:Mothers; D013501:Surface-Active Agents
chemical_list: D052244:Endocrine Disruptors; D013501:Surface-Active Agents; D004051:Diethylhexyl Phthalate