[Efficacy of antimicrobial prophylaxis in neurosurgical operations].
OBJECTIVE
It is reported that antimicrobial prophylaxis (AMP) reduces the incidence of surgical site infection (SSI) in neurological surgery. However, a great deal of variation exists regarding the type of antibiotics, dose, timing and duration. In this study, the authors analyzed the incidence of SSI comparing two different AMP protocols.


METHODS
Five hundred and fifty patients who had undergone neurosurgeries at our institute between April 2005 and August 2007 were reviewed retrospectively. They were divided into the protocol F (309 patients with two or more days AMP) and the protocol P (241 patients with one-day AMP).


RESULTS
Baseline characteristics were not statistically different between two protocols. The overall rate of SSI was 1.5%. Although SSI showed a trend of low SSI incidence in the protocol P (0.8%), this was not statistically significant compared with that in the protocol F (1.9%).


CONCLUSIONS
The one-day (< 24 hours) administration of AMP is enough to prevent SSI in neurological surgery.
Morofuji
Yoichi
Y
Department of Neurosurgery, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
Ishizaka
Shunsuke
S
Takeshita
Tomonori
T
Toyoda
Keisuke
K
Ujifuku
Kenta
K
Hirose
Makoto
M
Izumo
Tsuyoshi
T
Tsunoda
Keishi
K
Hayashi
Kentaro
K
Matsuo
Takayuki
T
Kitagawa
Naoki
N
Suyama
Kazuhiko
K
Nagata
Izumi
I
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D019072:Antibiotic Prophylaxis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D019990:Perioperative Care; D017410:Practice Guidelines as Topic; D012189:Retrospective Studies; D013530:Surgical Wound Infection / Q000517:prevention & control*; D013997:Time Factors
D000900:Anti-Bacterial Agents