Phomoeuphorbins A-D, azaphilones from the fungus Phomopsis euphorbiae.
Four azaphilones, named phomoeuphorbins A-D (1-4) were isolated from cultures of Phomopsis euphorbiae, an endophytic fungus isolated from Trewia nudiflora. Structures of 1-4 were established on the basis of spectroscopic analyses, including application of 2D NMR spectroscopic techniques. Phomoeuphorbins A and C exhibited very weak inhibitory activities against HIV replication in C8166 cells in vitro.
Yu
Bu-Zhu
BZ
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.
Zhang
Gao-Hong
GH
Du
Zhi-Zhi
ZZ
Zheng
Yong-Tang
YT
Xu
Jian-Chu
JC
Luo
Xiao-Dong
XD
D001578:Benzopyrans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D005658:Fungi / Q000737:chemistry*; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010860:Pigments, Biological / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects
D001578:Benzopyrans; D010860:Pigments, Biological; C494154:azaphilone; C535021:phomoeuphorbin A; C535022:phomoeuphorbin C