Manganese superoxide dismutase gene Ala-9Val polymorphism might be related to the severity of abnormal involuntary movements in Korean schizophrenic patients.
OBJECTIVE
This study examined whether the manganese superoxide dismutase (MnSOD) gene Ala-9Val single-nucleotide polymorphism (SNP) is associated with neuroleptic-induced tardive dyskinesia (TD) and the severity of the abnormal involuntary movements in Korean schizophrenic patients.


METHODS
We investigated whether the MnSOD gene Ala-9Val SNP is associated with TD in Korean schizophrenic patients with (n=83) and without (n=126) TD who were matched for exposure to antipsychotics and other relevant variables.


RESULTS
Logistic regression analysis revealed that being older (p=0.026) was a risk factor for TD, but that there was no significant association between MnSOD gene and TD. Abnormal involuntary movements were more severe in carriers of the Ala allele than in noncarriers (p=0.044).


CONCLUSIONS
These findings do not support that the MnSOD gene Ala-9Val SNP is associated with TD in Korean schizophrenic patients. However, this polymorphism might be related to the severity of abnormal involuntary movements in this population.
Kang
Seung-Gul
SG
Department of Psychiatry, Korea University College of Medicine, Seoul, South Korea.
Choi
Jung-Eun
JE
An
Hyonggin
H
Park
Young-Min
YM
Lee
Heon-Jeong
HJ
Han
Changsu
C
Kim
Yong-Ku
YK
Kim
Seung-Hyun
SH
Cho
Sung Nam
SN
Joe
Sook-Haeng
SH
Jung
In-Kwa
IK
Kim
Leen
L
Lee
Min-Soo
MS
D000328:Adult; D000409:Alanine / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007723:Korea; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000209:etiology / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012559:Schizophrenia / Q000150:complications / Q000235:genetics; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D013482:Superoxide Dismutase / Q000235:genetics*; D014633:Valine / Q000235:genetics*
D013482:Superoxide Dismutase; D014633:Valine; D000409:Alanine