Exploring synthetic routes to nucleoside alkynylphosphonates.
Alkynylphosphonates belong to a very interesting family as they may be viewed as precursors to a wide range of functionalized derivatives. Considering our ongoing research on 5'-mononucleotides of biological interest, we embarked on the synthesis of such compounds. Despite a limited number of steps, the nucleosidic pathway appeared disappointing. Therefore, an osidic pathway was explored and proved to be interesting. The corresponding optimization study and the synthesis of a new series of nucleoside alkynylphosphonates are described herein.
Meurillon
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M
Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS-UM1-UM2, Equipe Nucléosides Effecteurs Phosphorylés, Université Montpellier 2, cc1705, place Eugène Bataillon, Montpellier, France.
Peyrottes
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S
Périgaud
C
C
D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry; D009711:Nucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry
D000475:Alkenes; D009711:Nucleotides; D063065:Organophosphonates