title: Brominated flame retardants and other organochlorine pollutants in human adipose tissue samples from the Czech Republic.
abstract: Brominated flame retardants (BFRs) represented by polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecane (HBCD) together with major persistent organochlorine pollutants, polychlorinated biphenyls (PCBs) and selected organochlorine pesticides (OCPs), were determined in adipose tissue samples (n=98) obtained by liposuction of Czech subjects. Compared to other organochlorine pollutants (mostly PCBs and DDTs), levels of PBDE were lower by 2 orders of magnitude ranging from 0.2 to 54.3 ng/g lipid weight. PBDE congeners No. 47, 99, 153 and 183 were the most abundant constituting up to 90% of these pollutants in adipose tissue. The PBDEs content measured in this study was comparable with data reported in similar samples collected in Spain, Sweden, Belgium and Japan, whilst slightly lower than in the United States. Regarding PCBs, the dominating congeners were No. 138, 153 and 180 representing up to 90% of indicator congeners. The levels of PCBs were similar to those found in other European countries. While no age dependency was found for PBDEs, an increase of PCB and OCP levels with age was observed. Different exposure routes of donors were documented by the absence of the relationship between PCBs and OCPs.
authors.affiliation: Department of Food Chemistry and Analysis, Institute of Chemical Technology Prague, Technická 3, 166 28 Prague 6, Czech Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Pulkrabová
authors.forename: Petra
authors.initials: P
authors.lastname: Hrádková
authors.forename: Jana
authors.initials: J
authors.lastname: Hajslová
authors.forename: Jan
authors.initials: J
authors.lastname: Poustka
authors.forename: Michaela
authors.initials: M
authors.lastname: Nápravníková
authors.forename: Václav
authors.initials: V
authors.lastname: Polácek
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry*; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D018153:Czech Republic; D005260:Female; D005411:Flame Retardants / Q000032:analysis*; D006801:Humans; D006842:Hydrocarbons, Brominated / Q000032:analysis*; D008297:Male; D008875:Middle Aged
chemical_list: D005411:Flame Retardants; D006842:Hydrocarbons, Brominated