Expression and function of ETA and ETB receptors in SSc.
Endothelin (ET) receptors are widely expressed within the human body with one of their major functions being regulation of the vascular tone. Pulmonary arterial hypertension and other complications associated with SSc are related to the function and or dysregulation of these receptors. As ET receptors also play a crucial role in SSc, this review will discuss the expression and physiological functions of ET receptors in the human organism, their signalling pathways, the complications of diseases they are associated with and their importance as a therapeutic target in SSc.
Frommer
K W
KW
Department of Internal Medicine and Rheumatology, Justus-Liebig University Giessen, Kerckhoff-Klinik Bad Nauheim, Bad Nauheim, Germany. k.frommer@kerckhoff-klinik.de
Müller-Ladner
U
U
D003331:Coronary Vessels / Q000378:metabolism; D065130:Endothelin A Receptor Antagonists; D065131:Endothelin B Receptor Antagonists; D006801:Humans; D007672:Kidney Cortex / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D044022:Receptor, Endothelin A / Q000032:analysis / Q000378:metabolism*; D044023:Receptor, Endothelin B / Q000032:analysis / Q000378:metabolism*; D012595:Scleroderma, Systemic / Q000188:drug therapy / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D014661:Vasoconstriction / Q000502:physiology
D065130:Endothelin A Receptor Antagonists; D065131:Endothelin B Receptor Antagonists; D044022:Receptor, Endothelin A; D044023:Receptor, Endothelin B