title: Developmental switch in requirement for PKA RIIbeta in NMDA-receptor-dependent synaptic plasticity at Schaffer collateral to CA1 pyramidal cell synapses.
abstract: The cAMP/protein kinase A (PKA) signaling cascade is crucial for synaptic plasticity in a wide variety of species. PKA regulates Ca2+ permeation through NMDA receptors (NMDARs) and induction of NMDAR-dependent synaptic plasticity at the Schaffer collateral to CA1 pyramidal cell synapse. Whereas the role of PKA in induction of NMDAR-dependent LTP at CA1 synapses is established, the identity of PKA isoforms involved in this phenomenon is less clear. Here we report that protein synthesis-independent NMDAR-dependent LTP at the Schaffer collateral-CA1 synapse in the hippocampus is deficient, but NMDAR-dependent LTD is normal, in young (postnatal day 10 (P10)-P14) mice lacking PKA RIIbeta, the PKA regulatory protein that links PKA to NMDARs at synaptic sites. In contrast, in young adult (P21-P28) mice lacking PKA RIIbeta, LTP is normal and LTD is abolished. These findings indicate that distinct PKA isoforms may subserve distinct forms of synaptic plasticity and are consistent with a developmental switch in the signaling cascades required for LTP induction.
authors.affiliation: Dominick P. Purpura Department of Neuroscience, Kennedy Center Room 602B, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
authors.forename: Yupeng
authors.initials: Y
authors.lastname: Yang
authors.forename: Koichi
authors.initials: K
authors.lastname: Takeuchi
authors.forename: Alma
authors.initials: A
authors.lastname: Rodenas-Ruano
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Takayasu
authors.forename: Michael V L
authors.initials: MV
authors.lastname: Bennett
authors.forename: R Suzanne
authors.initials: RS
authors.lastname: Zukin
mesh_terms: D018750:6-Cyano-7-nitroquinoxaline-2,3-dione / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D001703:Biophysics; D054757:Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit / Q000172:deficiency / Q000502:physiology*; D004558:Electric Stimulation; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D006624:Hippocampus / Q000166:cytology*; D066298:In Vitro Techniques; D051379:Mice; D018345:Mice, Knockout; D016202:N-Methylaspartate / Q000494:pharmacology; D009434:Neural Pathways / Q000502:physiology; D009473:Neuronal Plasticity / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D017966:Pyramidal Cells / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology*; D013569:Synapses / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D013997:Time Factors; D014633:Valine / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D054757:Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit; D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D016202:N-Methylaspartate; D018750:6-Cyano-7-nitroquinoxaline-2,3-dione; C056639:2-amino-5-phosphopentanoic acid; D014633:Valine
references.citation: Nat Rev Mol Cell Biol. 2004 Dec;5(12):959-70
references.pmid: 15573134
references.citation: Neuron. 1998 Nov;21(5):1163-75
references.pmid: 9856471
references.citation: Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14859-64
references.pmid: 9405704
references.citation: J Biol Chem. 1997 May 2;272(18):12107-15
references.pmid: 9115280
references.citation: Cell. 1995 Dec 29;83(7):1211-22
references.pmid: 8548807
references.citation: Nature. 1994 May 19;369(6477):230-2
references.pmid: 8183343
references.citation: Neuron. 1992 Nov;9(5):967-75
references.pmid: 1419003
references.citation: Eur J Neurosci. 2000 Jan;12(1):360-6
references.pmid: 10651891
references.citation: Neuron. 1997 Jun;18(6):969-82
references.pmid: 9208864
references.citation: J Neurosci. 2004 Oct 13;24(41):9049-58
references.pmid: 15483123
references.citation: Nat Neurosci. 2003 Feb;6(2):136-43
references.pmid: 12536214
references.citation: Neuron. 2004 Sep 30;44(1):5-21
references.pmid: 15450156
references.citation: EMBO J. 2007 Nov 28;26(23):4879-90
references.pmid: 17972919
references.citation: Pharmacol Rev. 1999 Mar;51(1):7-61
references.pmid: 10049997
references.citation: Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8851-5
references.pmid: 7568030
references.citation: Nat Neurosci. 2003 Jan;6(1):15-6
references.pmid: 12469130
references.citation: Nat Rev Neurosci. 2000 Nov;1(2):133-41
references.pmid: 11252776
references.citation: J Neurosci. 2000 Jun 15;20(12):4446-51
references.pmid: 10844013
references.citation: Science. 1998 Jun 19;280(5371):1940-2
references.pmid: 9632393
references.citation: Neuron. 1996 Feb;16(2):415-21
references.pmid: 8789956
references.citation: Annu Rev Neurosci. 2002;25:103-26
references.pmid: 12052905
references.citation: J Biol Chem. 1992 Aug 25;267(24):16816-23
references.pmid: 1512224
references.citation: Science. 1999 Jul 2;285(5424):93-6
references.pmid: 10390370
references.citation: Annu Rev Physiol. 2002;64:355-405
references.pmid: 11826273
references.citation: J Neurosci. 2006 Apr 19;26(16):4338-49
references.pmid: 16624954
references.citation: Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1571-6
references.pmid: 8643673
references.citation: Nature. 1996 Aug 15;382(6592):622-6
references.pmid: 8757131
references.citation: J Neurosci. 2007 Sep 19;27(38):10278-88
references.pmid: 17881534
references.citation: Nat Rev Neurosci. 2004 Dec;5(12):952-62
references.pmid: 15550950
references.citation: Prog Neurobiol. 2003 Dec;71(6):401-37
references.pmid: 15013227
references.citation: J Cell Biol. 2003 Jan 6;160(1):101-12
references.pmid: 12507994
references.citation: J Biol Chem. 1997 Feb 14;272(7):3993-8
references.pmid: 9020105
references.citation: Science. 1996 Nov 15;274(5290):1133-8
references.pmid: 8895456
references.citation: Cereb Cortex. 2003 Aug;13(8):864-9
references.pmid: 12853373
references.citation: Eur J Cell Biol. 2006 Jul;85(7):635-42
references.pmid: 16600423
references.citation: Curr Opin Neurobiol. 1997 Jun;7(3):397-403
references.pmid: 9232801
references.citation: J Neurobiol. 2006 Feb 15;66(3):205-19
references.pmid: 16329119
references.citation: Neurosci Lett. 1993 Oct 29;161(2):124-8
references.pmid: 8272253
references.citation: Trends Cell Biol. 1999 Jun;9(6):216-21
references.pmid: 10354567
references.citation: Trends Neurosci. 2002 Nov;25(11):571-7
references.pmid: 12392932
references.citation: Nat Rev Neurosci. 2007 Jun;8(6):413-26
references.pmid: 17514195
references.citation: Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3579-84
references.pmid: 17360685
references.citation: Sci STKE. 2004 Oct 19;2004(255):re16
references.pmid: 15494561
references.citation: J Biol Chem. 1997 Feb 21;272(8):5157-66
references.pmid: 9030583
references.citation: J Neurosci. 1994 Feb;14(2):645-54
references.pmid: 7905515
references.citation: Neuron. 2000 Jul;27(1):107-19
references.pmid: 10939335
references.citation: Nat Neurosci. 2001 Feb;4(2):159-63
references.pmid: 11175876
references.citation: Learn Mem. 1994 May-Jun;1(1):74-82
references.pmid: 10467587
references.citation: Nat Neurosci. 2000 Nov;3(11):1098-106
references.pmid: 11036266
references.citation: Cell. 1997 Mar 7;88(5):615-26
references.pmid: 9054501
references.citation: Nat Neurosci. 2006 Apr;9(4):501-10
references.pmid: 16531999
references.citation: Curr Opin Neurobiol. 1998 Feb;8(1):139-48
references.pmid: 9568401
references.citation: J Neurosci. 1998 Dec 15;18(24):10297-303
references.pmid: 9852567