title: Bipolar disorders and quality of life: the impact of attention deficit/hyperactivity disorder and substance abuse in euthymic patients.
abstract: Patients with bipolar disorders (BPD) display high rates of comorbidities, especially substance abuse (20-40%) and attention deficit/hyperactivity disorder (ADHD) (6%-20%). However, there are virtually no data evaluating the role of current ADHD on the global functioning of patients with BPD. The recent literature suggests that impairments in quality of life are a key prognostic feature for predicting the long course of BPD. The aim of this study was to investigate the intrinsic impact of adult ADHD and substance abuse in patients with BPD on levels of social adaptation, functioning and vitality. Seventy-three outpatients with BPD I or II, all euthymic and being treated with mood stabilizers, were evaluated using the following measures: 1) the Diagnostic Interview of Genetics Study for DSM-IV criteria; 2) the ADHD Self-Report Scale (ASRS) (screening of adult ADHD); 3) measures of quality of life: social adaptation (Social Adjustment Scale Self-Report (SAS-SR)), well-being (Short Form 36 (SF-36) Health Survey), and the Brief Psychiatric Rating Scale. In this clinical sample, 30% met the ADHD criteria and 22% were substance abusers. The results showed that the presence of ADHD in BPD patients significantly predicted a low social functioning and adaptation by comparison with BPD patients without ADHD. By contrast, we failed to detect a significant impact of substance abuse on those functional outcomes. This is the first step towards improved screening for comorbidities and an understanding of their crucial role in the prognosis of the disorder, as well as in defining new multilevel therapeutic strategies.
authors.affiliation: INSERM, U796, 2 ter Rue d'Alésia, Paris 75014, France. o.sentissi@ch-sainte-anne.fr
authors.forename: Othman
authors.initials: O
authors.lastname: Sentissi
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Navarro
authors.forename: Hercilia
authors.initials: H
authors.lastname: De Oliveira
authors.forename: David
authors.initials: D
authors.lastname: Gourion
authors.forename: Marie Chantal
authors.initials: MC
authors.lastname: Bourdel
authors.forename: Franck Jean
authors.initials: FJ
authors.lastname: Baylé
authors.forename: Jean Pierre
authors.initials: JP
authors.lastname: Olié
authors.forename: Marie France
authors.initials: MF
authors.lastname: Poirier
mesh_terms: D000328:Adult; D000339:Affect; D000927:Anticonvulsants / Q000627:therapeutic use; D018692:Antimanic Agents / Q000627:therapeutic use; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000523:psychology* / Q000534:rehabilitation; D001714:Bipolar Disorder / Q000175:diagnosis / Q000523:psychology* / Q000534:rehabilitation; D015897:Comorbidity; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life / Q000523:psychology*; D012917:Social Adjustment; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000523:psychology* / Q000534:rehabilitation
chemical_list: D000927:Anticonvulsants; D018692:Antimanic Agents