title: Building biologically active nucleic acid nanocomplexes.
abstract: The Bioplex technology allows the hybridization of functional entities to various forms of nucleic acids by the use of synthetic nucleic acid analogs. Such supramolecular assemblies can be made in a predetermined fashion and can confer new properties. The Zorro technology is based on a novel construct generated to simultaneously bind to both DNA strands. Such compounds may have gene silencing activity.
authors.affiliation: Department of Laboratory Medicine, Clinical Research Center, Karolinska Institutet, Karolinska University Hospital, 141 86 Huddinge, Sweden.
authors.forename: C I Edvard
authors.initials: CI
authors.lastname: Smith
authors.forename: Karin E
authors.initials: KE
authors.lastname: Lundin
authors.forename: Oscar E
authors.initials: OE
authors.lastname: Simonson
authors.forename: Pedro M D
authors.initials: PM
authors.lastname: Moreno
authors.forename: Mathias G
authors.initials: MG
authors.lastname: Svahn
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Wenska
authors.forename: Roger
authors.initials: R
authors.lastname: Strömberg
mesh_terms: D021581:Active Transport, Cell Nucleus; D002467:Cell Nucleus / Q000378:metabolism; D004247:DNA / Q000737:chemistry; D020868:Gene Silencing; D049329:Nanostructures / Q000737:chemistry*; D009693:Nucleic Acid Hybridization; D009696:Nucleic Acids / Q000378:metabolism; D009841:Oligonucleotides / Q000737:chemistry*; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D010957:Plasmids / Q000737:chemistry
chemical_list: D009696:Nucleic Acids; D009841:Oligonucleotides; D020135:Peptide Nucleic Acids; C477371:locked nucleic acid; D004247:DNA