title: Design, synthesis and antiproliferative activity of two new heteroannelated (-)-muricatacin mimics.
abstract: Two new (-)-muricatacin mimics bearing a furano-furanone ring and an oxygen isostere in the side chain have been designed and synthesized and their in vitro antiproliferative activity was evaluated against several human tumour cell lines. Both analogues showed an increased activity against HL-60 cells with 17- and 185-fold higher potency than (-)-muricatacin. A straightforward synthesis of (-)-muricatacin is also disclosed.
authors.affiliation: Department of Chemistry, Faculty of Sciences, University of Novi Sad, Trg D. Obradovića 3, 21000 Novi Sad, Serbia. popsavin@ih.ns.ac.yu
authors.forename: Velimir
authors.initials: V
authors.lastname: Popsavin
authors.forename: Bojana
authors.initials: B
authors.lastname: Srećo
authors.forename: Goran
authors.initials: G
authors.lastname: Benedeković
authors.forename: Mirjana
authors.initials: M
authors.lastname: Popsavin
authors.forename: Jovana
authors.initials: J
authors.lastname: Francuz
authors.forename: Vesna
authors.initials: V
authors.lastname: Kojić
authors.forename: Gordana
authors.initials: G
authors.lastname: Bogdanović
mesh_terms: D029061:Annonaceae / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D018922:HL-60 Cells; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D005663:Furans; C082488:muricatacin