title: Unilateral juvenile (virginal) hypertrophy of the breast.
abstract: Juvenile hypertrophy of the breast (JHB) is an uncommon, benign disorder and typically occurs in peri-pubertal females. The etiology ofJHB is uncertain. It may represent an end-organ hypersensitivity of the breast to normal levels of sex steroids. Clinically, it is characterized by rapid enlargement of breasts, either unilateral or bilateral. The definitive diagnosis is made by histopathologic examination. Treatment recommendations include surgery and hormonal therapy, although hormonal manipulation is still controversial in pediatric patients. Here we report a 13-year-old girl with unilateral JHB who did not require surgery or medical treatment.
authors.affiliation: Department of Pediatric Oncology, Dokuz Eylül University Institute of Oncology, Izmir, Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Güneş
authors.forename: Kamer
authors.initials: K
authors.lastname: Mutafoğlu-Uysal
authors.forename: Tülay
authors.initials: T
authors.lastname: Canda
authors.forename: Serdar
authors.initials: S
authors.lastname: Saydam
authors.forename: Ayşe Pinar
authors.initials: AP
authors.lastname: Cemeroğlu
authors.forename: Nur
authors.initials: N
authors.lastname: Olgun
mesh_terms: D000293:Adolescent; D001940:Breast / Q000473:pathology*; D005260:Female; D006801:Humans; D006984:Hypertrophy