Enantioselective radical conjugate addition to alpha'-phosphoric enones.
Catalytic enantioselective radical conjugate addition reactions using alpha'-phosphoric enone templates have been studied. The C 2-symmetric bisoxazoline-zinc(II) complex proves to be effective for high enantioselectivities and chemical yields. In addition, intermediate alpha-carbonyl alkyl radicals could be trapped with allyltributylstannane to afford anti-isomers as major products with high enantioselectivities.
Lee
Sunggi
S
Department of Chemistry, School of Molecular Science (BK-21), Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Korea.
Kim
Sunggak
S