[Cytogenetic and molecular genetic alterations on chromosome 4q in human hepatocellular carcinoma].
The carcinogenesis of hepatocellular carcinoma (HCC) is a multi-factor, multi-step, multi-gene and complicated process. Specific chromosome losses and corresponding inactivation of tumor suppressor genes (TSGs) are frequently detected during the development of HCC. A high frequency of loss on chromosome 4q in HCC has been reported, suggesting that the dysfunction of specific TSGs on this chromosome arm is involved in the development and progression of HCC. In this article, we reviewed the studies on chromosomal loss of 4q in HCC patients using cytogenetic and molecular genetic technologies, such as fluorescence in situ hybridization (FISH), comparative genomic hybridization (CGH) and loss of heterozygosity (LOH) analysis; we also summarized the regions of chromosome 4q with high frequency of loss in HCC patients from different countries, and discussed their relationships with clinical parameters including hepatitis B virus (HBV) infection, tumor differentiation and tumor size, and listed potential TSGs on chromosome 4q in HCC patients.
Zhang
Hua-Kun
HK
State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, PR China.
Wang
Hui-Yun
HY
Xia
Jian-Chuan
JC
D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000378:metabolism; D002872:Chromosome Deletion; D002894:Chromosomes, Human, Pair 4; D055028:Comparative Genomic Hybridization; D004268:DNA-Binding Proteins / Q000378:metabolism; D016147:Genes, Tumor Suppressor; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008113:Liver Neoplasms / Q000235:genetics* / Q000378:metabolism; D019656:Loss of Heterozygosity / Q000235:genetics; D018895:Microsatellite Repeats; D009363:Neoplasm Proteins / Q000378:metabolism; D009687:Nuclear Proteins; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D054595:Protein Tyrosine Phosphatase, Non-Receptor Type 13 / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
D004268:DNA-Binding Proteins; C473950:NAP1L5 protein, human; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; C487762:PRDM5 protein, human; D014157:Transcription Factors; C516742:PTPN13 protein, human; D054595:Protein Tyrosine Phosphatase, Non-Receptor Type 13