Peptoid architectures: elaboration, actuation, and application.
Peptoids are peptidomimetic oligomers composed of N-substituted glycine units. Their convenient synthesis enables strict control over the sequence of highly diverse monomers and is capable of generating extensive compound libraries. Recent studies are beginning to explore the relationship between peptoid sequence, structure and function. We describe new approaches to direct the conformation of the peptoid backbone, leading to secondary structures such as helices, loops, and turns. These advances are enabling the discovery of bioactive peptoids and will establish modules for the design and assembly of protein mimetics.
Yoo
Barney
B
Department of Chemistry, New York University, 100 Washington Square E., Room 1001, New York, NY 10003, USA.
Kirshenbaum
Kent
K
D000595:Amino Acid Sequence; D015195:Drug Design; D034444:Peptoids / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D017433:Protein Structure, Secondary
D034444:Peptoids