Differences in the expression pattern of P-glycoprotein and MRP1 in low-grade and high-grade gliomas.
Multidrug resistance in gliomas is the major challenges in the clinical setting. We investigated the expression of P-glycoprotein (Pgp) and multidrug resistance-related protein 1 (MRP1) in 50 gliomas using immunohistochemistry. Compared to Pgp, MRP1 positivity was observed in highest percentage of gliomas grade IV samples (p = 0.008). Unlike MRP1 expression observed in high-grade, gliomas grade II exhibited a greater number of Pgp positive samples as compared to grades III and IV (p = 0.026). Our results suggest that the difference between the histological grade gliomas regarding MRP1 and Pgp expression must have implications in the choice of chemotherapeutic protocols.
de Faria
Giselle Pinto
GP
Laboratório de Hematologia Celular e Molecular, Serviço de Hematologia, Hospital do Câncer, Instituto Nacional de Câncer, Rio de Janeiro, Brazil.
de Oliveira
José Antônio
JA
de Oliveira
José Gustavo Pugliese
JG
Romano
Sérgio de Oliveira
Sde O
Neto
Vivaldo Moura
VM
Maia
Raquel Ciuvalschi
RC
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000096:biosynthesis*; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D005910:Glioma / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000096:biosynthesis*; D009367:Neoplasm Staging; D055815:Young Adult
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D027425:ATP-Binding Cassette, Sub-Family C Proteins; C421109:multidrug resistance-associated protein 1