Formulations for delivery of therapeutic proteins.
Advances in biotechnology have now created a capacity to produce therapeutically active proteins on a commercial scale, opening the potential for their application in an array of disease conditions. The process of translation of the variety of different therapeutic proteins into the medicines used in clinics is now occurring. To assist in this translation, new formulations to deliver proteins could play an important role. These new formulations need to more adequately address the pharmacological and therapeutic requirement for each particular protein/peptide and, in that way, either improve present therapies or extend with new entries the current list of protein based medicines used in clinic.
Stolnik
Snjezana
S
Drug Delivery and Tissue Engineering Division, School of Pharmacy, University of Nottingham, University Park NG72RD, UK. snjezana.stolnik@nottingham.ac.uk
Shakesheff
Kevin
K
D000818:Animals; D003593:Cytoplasm / Q000378:metabolism; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D006801:Humans; D042541:Intracellular Space / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D011506:Proteins / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use*
D003692:Delayed-Action Preparations; D004364:Pharmaceutical Preparations; D011506:Proteins