title: Perinatal choline deficiency produces abnormal sensory inhibition in Sprague-Dawley rats.
abstract: Adequate choline levels in rodents during gestation have been shown to be critical to several functions, including certain learning and memory functions, when tested at adulthood. Choline is a selective agonist for the alpha7 nicotinic receptor which appears in development before acetylcholine is present. Normal sensory inhibition is dependent, in part, upon sufficient numbers of this receptor in the hippocampus. The present study assessed sensory inhibition in Sprague-Dawley rats gestated on normal (1.1 g/kg), deficient (0 g/kg) or supplemented (5 g/kg) choline in the maternal diet during the critical period for cholinergic cell development (E12-18). Rats gestated on deficient choline showed abnormal sensory inhibition when tested at adulthood, while rats gestated on normal or supplemented choline showed normal sensory inhibition. Assessment of hippocampal alpha-bungarotoxin to visualize nicotinic alpha7 receptors revealed no difference between the gestational choline levels. These data suggest that attention to maternal choline levels for human pregnancy may be important to the normal functioning of the offspring.
authors.affiliation: Medical Research Service, Department of Veterans Affairs Medical Center, Denver, CO, USA. karen.stevens@ucdenver.edu
authors.forename: Karen E
authors.initials: KE
authors.lastname: Stevens
authors.forename: Catherine E
authors.initials: CE
authors.lastname: Adams
authors.forename: Tiffany J
authors.initials: TJ
authors.lastname: Mellott
authors.forename: Emily
authors.initials: E
authors.lastname: Robbins
authors.forename: Michael A
authors.initials: MA
authors.lastname: Kisley
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000818:Animals; D000831:Animals, Newborn; D002038:Bungarotoxins / Q000378:metabolism; D002794:Choline / Q000008:administration & dosage / Q000494:pharmacology*; D002796:Choline Deficiency / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory / Q000187:drug effects / Q000502:physiology; D005260:Female; D006624:Hippocampus / Q000378:metabolism; D007266:Inhibition, Psychological; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time; D013216:Reflex, Startle / Q000502:physiology
chemical_list: D002038:Bungarotoxins; D002794:Choline
references.citation: Ann N Y Acad Sci. 1992 Jul 1;658:111-27
references.pmid: 1497255
references.citation: Schizophr Res. 1993 Aug;10(2):131-41
references.pmid: 8398945
references.citation: Front Integr Neurosci. 2008 May 03;1:7
references.pmid: 18958235
references.citation: Brain Res Dev Brain Res. 1999 Jun 2;115(2):123-9
references.pmid: 10407130
references.citation: Science. 1998 Aug 7;281(5378):794-5
references.pmid: 9714685
references.citation: Brain Res Dev Brain Res. 2000 Sep 30;123(1):25-32
references.pmid: 11020547
references.citation: Genes Dev. 1998 Aug 1;12(15):2245-62
references.pmid: 9694791
references.citation: FASEB J. 2004 Mar;18(3):545-7
references.pmid: 14715695
references.citation: Neurosci Lett. 1996 Aug 9;213(3):201-4
references.pmid: 8873149
references.citation: Neurosci Biobehav Rev. 2006;30(5):696-712
references.pmid: 16504295
references.citation: Neuroscience. 1993 Jul;55(2):373-80
references.pmid: 7690909
references.citation: Dev Biol. 1974 Jan;36(1):130-41
references.pmid: 4822829
references.citation: J Neurophysiol. 2004 Apr;91(4):1545-55
references.pmid: 14645379
references.citation: Biol Psychiatry. 1990 Jan 15;27(2):183-92
references.pmid: 2294981
references.citation: Brain Res. 1997 Nov 21;776(1-2):111-6
references.pmid: 9439802
references.citation: Brain Res. 1991 Jul 26;555(1):91-8
references.pmid: 1681997
references.citation: Nutrition. 2000 Jul-Aug;16(7-8):669-71
references.pmid: 10906592
references.citation: Psychopharmacology (Berl). 1998 Apr;136(4):320-7
references.pmid: 9600576
references.citation: J Neurosci. 1998 Feb 15;18(4):1187-95
references.pmid: 9454829
references.citation: Nature. 1977 Apr 28;266(5605):848-50
references.pmid: 865607
references.citation: Behav Neurosci. 1989 Dec;103(6):1234-41
references.pmid: 2610916
references.citation: FASEB J. 2006 Jan;20(1):43-9
references.pmid: 16394266
references.citation: Schizophr Bull. 1996;22(3):431-45
references.pmid: 8873294
references.citation: Neuropharmacology. 1992 Oct;31(10):1041-8
references.pmid: 1436386
references.citation: Prog Exp Pers Res. 1964;72:1-47
references.pmid: 14348121
references.citation: J Neurosci. 1993 May;13(5):1965-75
references.pmid: 8478687
references.citation: J Nutr. 2002 Jul;132(7):1840-7
references.pmid: 12097657
references.citation: Learn Mem. 2006 Mar-Apr;13(2):127-34
references.pmid: 16547161
references.citation: Am J Psychiatry. 1993 Dec;150(12):1856-61
references.pmid: 8238642
references.citation: J Neurochem. 2004 Jun;89(5):1252-9
references.pmid: 15147518
references.citation: Psychopharmacology (Berl). 2005 Nov;183(1):13-9
references.pmid: 16136299
references.citation: Brain Res. 1998 Jun 1;794(2):225-38
references.pmid: 9622639
references.citation: Dev Biol. 1974 Jan;36(1):142-54
references.pmid: 4822830
references.citation: Annu Rev Nutr. 1994;14:269-96
references.pmid: 7946521
references.citation: Biol Psychiatry. 1983 Sep;18(9):989-1005
references.pmid: 6416309
references.citation: Clin Chim Acta. 1985 Jun 30;149(1):1-12
references.pmid: 4028430
references.citation: J Comp Neurol. 1988 Mar 1;269(1):87-95
references.pmid: 3361006
references.citation: Neuropsychopharmacology. 1996 Aug;15(2):152-62
references.pmid: 8840351
references.citation: Psychopharmacology (Berl). 2008 Jun;198(3):413-20
references.pmid: 18446322
references.citation: Brain Res Dev Brain Res. 1999 Mar 12;113(1-2):13-20
references.pmid: 10064869
references.citation: Int J Psychophysiol. 2008 Feb;67(2):91-100
references.pmid: 18036692
references.citation: Proc Natl Acad Sci U S A. 1994 Mar 1;91(5):1731-5
references.pmid: 8127873
references.citation: Pharmacol Biochem Behav. 1997 Aug;57(4):869-74
references.pmid: 9259018
references.citation: Pharmacol Ther. 2002 Feb-Mar;93(2-3):125-33
references.pmid: 12191605
references.citation: Brain Res Dev Brain Res. 1999 Dec 10;118(1-2):159-67
references.pmid: 10611515
references.citation: Arch Gen Psychiatry. 2006 Jun;63(6):630-8
references.pmid: 16754836
references.citation: Eur J Neurosci. 1997 Dec;9(12):2734-42
references.pmid: 9517478
references.citation: Brain Res. 2002 Feb 22;928(1-2):85-95
references.pmid: 11844475
references.citation: J Pediatr. 2006 Nov;149(5 Suppl):S131-6
references.pmid: 17212955
references.citation: Neurosci Biobehav Rev. 2003 Sep;27(4):385-99
references.pmid: 12946691
references.citation: Brain Res Dev Brain Res. 1999 Dec 10;118(1-2):51-9
references.pmid: 10611503
references.citation: Neuroreport. 1997 Sep 29;8(14):3045-51
references.pmid: 9331912
references.citation: Eur J Pharmacol. 2000 Mar 30;393(1-3):237-42
references.pmid: 10771019
references.citation: Biol Psychiatry. 2003 Feb 1;53(3):244-53
references.pmid: 12559658
references.citation: Brain Res Dev Brain Res. 2002 Dec 15;139(2):175-87
references.pmid: 12480132
references.citation: Schizophr Bull. 1998;24(2):189-202
references.pmid: 9613620
references.citation: Biol Psychiatry. 1986 Jul;21(8-9):787-98
references.pmid: 3730461