title: Uremic lung: new insights into a forgotten condition.
abstract: The high mortality rate of acute kidney injury (AKI) despite advances in dialysis led to a renewed appreciation of the impact of AKI on distant organ dysfunction. Mechanistic studies demonstrated that AKI induces increased lung vascular permeability, soluble and cellular inflammation, and dysregulated salt and water channels. AKI also affects the brain, heart, liver, bone marrow, and gastrointestinal tract. Klein et al. now demonstrate that interleukin-6 is a direct mediator of AKI-induced lung changes.
authors.affiliation: Nephrology Division, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Scheel
authors.forename: Manchang
authors.initials: M
authors.lastname: Liu
authors.forename: Hamid
authors.initials: H
authors.lastname: Rabb
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications* / Q000401:mortality; D000818:Animals; D016207:Cytokines; D006801:Humans; D007107:Immune System; D007249:Inflammation; D008171:Lung Diseases / Q000209:etiology* / Q000473:pathology; D014511:Uremia / Q000150:complications*
chemical_list: D016207:Cytokines