title: Effects of inspiratory pause on CO2 elimination and arterial PCO2 in acute lung injury.
abstract: A high respiratory rate associated with the use of small tidal volumes, recommended for acute lung injury (ALI), shortens time for gas diffusion in the alveoli. This may decrease CO(2) elimination. We hypothesized that a postinspiratory pause could enhance CO(2) elimination and reduce Pa(CO(2)) by reducing dead space in ALI. In 15 mechanically ventilated patients with ALI and hypercapnia, a 20% postinspiratory pause (Tp20) was applied during a period of 30 min between two ventilation periods without postinspiratory pause (Tp0). Other parameters were kept unchanged. The single breath test for CO(2) was recorded every 5 min to measure tidal CO(2) elimination (VtCO(2)), airway dead space (V(Daw)), and slope of the alveolar plateau. Pa(O(2)), Pa(CO(2)), and physiological and alveolar dead space (V(Dphys), V(Dalv)) were determined at the end of each 30-min period. The postinspiratory pause, 0.7 +/- 0.2 s, induced on average <0.5 cmH(2)O of intrinsic positive end-expiratory pressure (PEEP). During Tp20, VtCO(2) increased immediately by 28 +/- 10% (14 +/- 5 ml per breath compared with 11 +/- 4 for Tp0) and then decreased without reaching the initial value within 30 min. The addition of a postinspiratory pause significantly decreased V(Daw) by 14% and V(Dphys) by 11% with no change in V(Dalv). During Tp20, the slope of the alveolar plateau initially fell to 65 +/- 10% of baseline value and continued to decrease. Tp20 induced a 10 +/- 3% decrease in Pa(CO(2)) at 30 min (from 55 +/- 10 to 49 +/- 9 mmHg, P < 0.001) with no significant variation in Pa(O(2)). Postinspiratory pause has a significant influence on CO(2) elimination when small tidal volumes are used during mechanical ventilation for ALI.
authors.affiliation: Medical Intensive Care Unit, AP-HP, INSERM Unit 841, Centre Hospitalier Albert Chenevier-Henri Mondor, Créteil, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Devaquet
authors.forename: Björn
authors.initials: B
authors.lastname: Jonson
authors.forename: Lisbet
authors.initials: L
authors.lastname: Niklason
authors.forename: Anne-Gaëlle
authors.initials: AG
authors.lastname: Si Larbi
authors.forename: Leif
authors.initials: L
authors.lastname: Uttman
authors.forename: Jérôme
authors.initials: J
authors.lastname: Aboab
authors.forename: Laurent
authors.initials: L
authors.lastname: Brochard
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001784:Blood Gas Analysis; D002245:Carbon Dioxide / Q000097:blood* / Q000378:metabolism*; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000378:metabolism* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000378:metabolism / Q000503:physiopathology; D011175:Positive-Pressure Respiration; D012121:Respiration, Artificial; D012126:Respiratory Dead Space / Q000502:physiology; D012128:Respiratory Distress Syndrome / Q000378:metabolism / Q000503:physiopathology; D015656:Respiratory Mechanics / Q000502:physiology*; D013990:Tidal Volume / Q000502:physiology
chemical_list: D002245:Carbon Dioxide
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