title: Mechanisms of action of antithymocyte globulin: old dogs with new tricks!
abstract: Understanding the mechanisms underlying immunological tolerance is the key to successful transplantation. Recent findings demonstrate that polyclonal antibodies such as the antithymocyte globulins preparations can provide wide spectrum immunomodulation, suggesting that their use in the immunosuppression therapeutic armamentarium may help in reducing the incidence of organ rejection and improving patients' outcome after hematopoietic stem cell transplantation.
authors.affiliation: Service d'Hematologie Clinique, Hopital Hotel-Dieu, CHU de Nantes, Nantes, France. mohamad.mohty@univ-nantes.fr
authors.forename: Mohamad
authors.initials: M
authors.lastname: Mohty
authors.forename: Beatrice
authors.initials: B
authors.lastname: Gaugler
mesh_terms: D015703:Antigens, CD / Q000276:immunology; D000961:Antilymphocyte Serum / Q000276:immunology* / Q000627:therapeutic use; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods*; D008214:Lymphocytes / Q000276:immunology
chemical_list: D015703:Antigens, CD; D000961:Antilymphocyte Serum