Synthesis and DNA binding studies of novel heterocyclic substituted quinoline schiff bases: a potent antimicrobial agent.
The present article deals with the synthesis of 2-chloroquinoline-3-carbaldehyde [(2-hydroxy-1-naphthyl) methylene] hydrazone (CQCMH) (2a-c) and 2-chloroquinoline-3-carbaldehyde [4-(dimethylamino) benzylidene] hydrazone (CQCDBH) (3a-c) from quinoline derivatives under suitable experimental conditions. The synthesized compounds were characterized by elemental analysis, FTIR, (1)HNMR, and mass spectral data. The selected compounds were studied for interaction with calf thymus-DNA (CT-DNA) by electronic spectra, viscosity measurements as well as thermal denaturation studies. On binding to DNA, the absorption spectrum underwent bathochromic and hypochromic shifts. The binding constant (K(b)) had value of 2.3 x 10(3) M(-1) for (2a) and 2.5 x 10(4) M(-1) for (3a). The viscosity measurements indicated that the viscosity of sonicated rod like DNA fragments increased. The synthesized derivatives have been screened for antibacterial and antifungal activities.
Lamani
Devappa S
DS
Department of Studies in Industrial Chemistry, Jnana Sahyadri Kuvempu University, Karnataka, India.
Venugopala Reddy
Kallam R
KR
Bhojya Naik
H S
HS
Savyasachi
A
A
Naik
H Raja
HR
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000378:metabolism; D004247:DNA / Q000378:metabolism*; D006835:Hydrazones / Q000138:chemical synthesis* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D011804:Quinolines / Q000138:chemical synthesis* / Q000378:metabolism; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000378:metabolism; D017550:Spectroscopy, Fourier Transform Infrared; D014783:Viscosity
D000890:Anti-Infective Agents; D006835:Hydrazones; D011804:Quinolines; D012545:Schiff Bases; D004247:DNA