title: Hydrolysis of single linkage in long DNA using oligonucleotide-multiphosphonate conjugates and Ce IV/EDTA.
abstract: Only one phosphodiester linkage in long DNA was hydrolyzed simply by using two components: oligonucleotide-multiphosphonate conjugates ("gapmers") and Ce(IV)/EDTA (Fig. 1).
authors.affiliation: Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, 153-8904, Japan.
authors.forename: Yuta
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Tuomas
authors.initials: T
authors.lastname: Lönnberg
authors.forename: Makoto
authors.initials: M
authors.lastname: Komiyama
mesh_terms: D002563:Cerium / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D004492:Edetic Acid / Q000737:chemistry*; D005029:Ethylenediamines / Q000737:chemistry*; D006868:Hydrolysis; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D063065:Organophosphonates / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000737:chemistry*
chemical_list: D005029:Ethylenediamines; D009841:Oligonucleotides; D063065:Organophosphonates; D009943:Organophosphorus Compounds; C418473:ethylenediaminetetrakis(methylphosphonic) acid; C041182:(nitrilotris(methylene))triphosphonic acid; D002563:Cerium; D004247:DNA; D004492:Edetic Acid