title: Laminar analysis of the role of GluR1 in experience-dependent and synaptic depression in barrel cortex.
abstract: Several synaptic depression mechanisms have been described for the hippocampus, cerebellum and neocortex in vitro, but little is known about which, if any, are engaged during experience-dependent depression (EDD). We found that EDD in the mouse barrel cortex depends on the AMPA subunit GluR1 in layers II/III and IV, but not in layer V, and that long-term depression is also GluR1 dependent in the IV-II/III, but not II/III-V, pathway.
authors.affiliation: Cardiff School of Biosciences, Cardiff University, Cardiff CF103US, UK.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Wright
authors.forename: Stanislaw
authors.initials: S
authors.lastname: Glazewski
authors.forename: Neil
authors.initials: N
authors.lastname: Hardingham
authors.forename: Keith
authors.initials: K
authors.lastname: Phillips
authors.forename: Eleftheria
authors.initials: E
authors.lastname: Pervolaraki
authors.forename: Kevin
authors.initials: K
authors.lastname: Fox
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D036881:Long-Term Synaptic Depression / Q000235:genetics / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D018091:Receptors, AMPA / Q000172:deficiency / Q000502:physiology*; D012683:Sensory Deprivation / Q000502:physiology; D013003:Somatosensory Cortex / Q000033:anatomy & histology* / Q000502:physiology*; D009435:Synaptic Transmission / Q000235:genetics / Q000502:physiology*; D014738:Vibrissae / Q000294:innervation
chemical_list: D018091:Receptors, AMPA
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