title: Inattentive/overactive children with histories of profound institutional deprivation compared with standard ADHD cases: a brief report.
abstract: BACKGROUND
  The Inattention/Overactivity/Impulsiveness (I/OA) behavioural cluster diagnostic of ADHD is recognized as a characteristic outcome of early institutional care.
  
  
  METHODS
  We compared the symptom and neuropsychological profiles of children with a history of I/OA and early severe deprivation (D-I/OA: n=13) with standard clinical ADHD cases (S-ADHD; N=20) and children who had experienced deprivation but were not pervasively I/OA (ERA-controls; n=22). The mean age of testing was around 13 years. D-I/OA and ERA-controls were selected from the English and Romanian Adoptees (ERA) study and had spent their early lives in the extremely depriving Romanian institutions of the Ceausescu regime and were later adopted into UK families.
  
  
  RESULTS
  ADHD symptoms for male D-I/OA and S-ADHD cases showed marked similarities across symptom domains. In contrast, girls with D-I/OA were more similar to ERA controls than to ADHD cases. Longitudinal data suggested that this was due to a remission of symptoms in D-I/OA girls. Neuropsychological profiles of males and females with D-I/OA, however, were similar: both were more impaired than S-ADHD and ERA controls.
  
  
  CONCLUSIONS
  Children with D-I/OA were more neuropsychologically impaired than S-ADHD despite the fact that only boys showed a persistent pattern of ADHD symptoms. These results need replication in a larger sample with groups matched for gender.
authors.affiliation: Developmental Brain-Behaviour Laboratory, School of Psychology, University of Southampton, Southampton, UK. ejb3@soton.ac.uk
authors.forename: E J S
authors.initials: EJ
authors.lastname: Sonuga-Barke
authors.forename: K
authors.initials: K
authors.lastname: Rubia
mesh_terms: D000293:Adolescent; D000300:Adoption / Q000523:psychology*; D001289:Attention Deficit Disorder with Hyperactivity / Q000523:psychology*; D002648:Child; D002674:Child, Institutionalized / Q000523:psychology*; D019955:Conduct Disorder / Q000523:psychology*; D004739:England; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000523:psychology*; D009483:Neuropsychological Tests; D011595:Psychomotor Agitation / Q000523:psychology; D011610:Psychosocial Deprivation; D012383:Romania; D013315:Stress, Psychological