Currently available antitussives.
Cough is among the most common complaints for which patients seek medical attention. Acute cough, usually due to a viral upper respiratory tract infection, generates a huge expenditure on prescription and over-the-counter cough and cold preparations worldwide. Most of these agents, however, have not been shown to be more effective than placebo in adequately performed clinical trials. The goal of management in chronic cough is treatment of its underlying cause. However, certain situations will necessitate cough suppressant therapy for symptomatic relief. Unfortunately, currently available antitussives, such as the opioids, are not consistently effective, or achieve therapeutic effect at the expense of unpleasant or intolerable side effects. Safer and more effective cough suppressants are desperately needed. Potential novel antitussives will need to be evaluated in properly formulated clinical trials, measuring relevant subjective and objective end points in appropriate subject populations.
Dicpinigaitis
Peter V
PV
Albert Einstein College of Medicine and Montefiore Medical Center, Einstein Division, Bronx, NY 10461, USA. pdicpinigaitis@pol.net
D000208:Acute Disease; D000701:Analgesics, Opioid / Q000627:therapeutic use; D000996:Antitussive Agents / Q000627:therapeutic use*; D001993:Bronchodilator Agents / Q000627:therapeutic use; D002908:Chronic Disease; D003371:Cough / Q000188:drug therapy* / Q000209:etiology; D005100:Expectorants / Q000627:therapeutic use; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D009294:Narcotics / Q000627:therapeutic use; D010276:Parasympatholytics / Q000627:therapeutic use; D012141:Respiratory Tract Infections / Q000150:complications / Q000188:drug therapy
D000701:Analgesics, Opioid; D000996:Antitussive Agents; D001993:Bronchodilator Agents; D005100:Expectorants; D006633:Histamine Antagonists; D009294:Narcotics; D010276:Parasympatholytics