title: New depot forms of AZT and 3TC based on their phosphonate derivatives: anti-HIV activity and pharmacokinetic parameters.
abstract: New phosphonate depot forms of AZT and 3TC were synthesized and their anti-HIV properties in cell systems, cellular uptake, intracellular transformations and some pharmacokinetic and toxicological data were studied.
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilov St, 119991 Moscow, Russia. kukhan86@hotmail.com
authors.forename: M K
authors.initials: MK
authors.lastname: Kukhanova
authors.forename: M V
authors.initials: MV
authors.lastname: Jasco
authors.forename: A V
authors.initials: AV
authors.lastname: Shipitzyn
authors.forename: D V
authors.initials: DV
authors.lastname: Yanvarev
authors.forename: A L
authors.initials: AL
authors.lastname: Khandazhynskaya
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D002460:Cell Line; D004285:Dogs; D019259:Lamivudine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D051379:Mice; D063065:Organophosphonates / Q000737:chemistry; D015215:Zidovudine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; D019259:Lamivudine; D015215:Zidovudine