title: Treatment with LXR agonists after focal cerebral ischemia prevents brain damage.
abstract: Stroke is characterized by massive inflammation in areas surrounding the injury that magnifies damage to the brain. The liver X receptors (LXRs) are nuclear receptors that regulate cholesterol, lipid, and glucose metabolism. Synthetic LXR agonists have potent anti-inflammatory properties in a variety of settings, including neuroinflammation. However, the ability of LXR agonists to suppress stroke-associated inflammation has not been evaluated. Here, we have used time-lapse magnetic resonance imaging (MRI) to show that a single dose of an LXR ligand administered post-injury dramatically reduces brain damage in a model of acute brain ischemia. Neuroprotection was associated with suppression of neuroinflammation.
authors.affiliation: Department of Pharmacological Sciences, University of Milan,Via G. Balzaretti 9, 20133 Milan, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Sironi
authors.forename: Nico
authors.initials: N
authors.lastname: Mitro
authors.forename: Mauro
authors.initials: M
authors.lastname: Cimino
authors.forename: Paolo
authors.initials: P
authors.lastname: Gelosa
authors.forename: Uliano
authors.initials: U
authors.lastname: Guerrini
authors.forename: Elena
authors.initials: E
authors.lastname: Tremoli
authors.forename: Enrique
authors.initials: E
authors.lastname: Saez
mesh_terms: D000818:Animals; D001565:Benzoates / Q000627:therapeutic use*; D001596:Benzylamines / Q000627:therapeutic use*; D002545:Brain Ischemia / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D002544:Cerebral Infarction / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D004268:DNA-Binding Proteins / Q000819:agonists*; D004195:Disease Models, Animal; D008024:Ligands; D000071518:Liver X Receptors; D008279:Magnetic Resonance Imaging; D008297:Male; D057093:Orphan Nuclear Receptors; D051381:Rats; D017207:Rats, Sprague-Dawley; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists*
chemical_list: D001565:Benzoates; D001596:Benzylamines; D004268:DNA-Binding Proteins; C473027:GW 3965; D008024:Ligands; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D018160:Receptors, Cytoplasmic and Nuclear
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