Paraspinal synovial sarcoma as an unusual postradiation complication in pediatric abdominal neuroblastoma.
The development of a soft-tissue sarcoma is an infrequent but well-known long-term complication of radiotherapy. Malignant fibrous histiocytomas, extraskeletal osteosarcomas, fibrosarcomas, malignant peripheral nerve sheath tumors, and angiosarcomas are most frequently encountered. Radiation-associated synovial sarcomas are uncommon and exceedingly rare in pediatric patients. We report an unusual case of paraspinal synovial sarcoma presenting in an adolescent female 13 years after radiation therapy for her neuroblastoma.
Mullah-Ali
Ali
A
Departments of Pediatric Hematology/Oncology, Division of Pediatrics, McMaster University, Hamilton, Ontario, Canada. mullah_ali@hotmail.com
Ramsay
Jennifer A
JA
Bourgeois
Jacqueline M
JM
Hodson
Ian
I
Macdonald
Paula
P
Midia
Mehran
M
Portwine
Carol
C
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics / Q000648:ultrastructure; D041321:Chromosomes, Human, X / Q000235:genetics / Q000648:ultrastructure; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D003606:Dacarbazine / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D007223:Infant; D008159:Lumbar Vertebrae; D008466:Mechlorethamine / Q000008:administration & dosage; D019042:Muscle Neoplasms / Q000188:drug therapy / Q000209:etiology* / Q000235:genetics / Q000532:radiotherapy; D009381:Neoplasms, Radiation-Induced / Q000188:drug therapy / Q000209:etiology* / Q000235:genetics / Q000532:radiotherapy; D016609:Neoplasms, Second Primary / Q000188:drug therapy / Q000209:etiology* / Q000235:genetics / Q000532:radiotherapy; D009447:Neuroblastoma / Q000188:drug therapy / Q000532:radiotherapy*; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D012074:Remission Induction; D012186:Retroperitoneal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D013584:Sarcoma, Synovial / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics / Q000532:radiotherapy; D013130:Spinal Stenosis / Q000209:etiology; D014178:Translocation, Genetic; D014750:Vincristine / Q000008:administration & dosage
D015514:Oncogene Proteins, Fusion; C116512:SYT-SSX fusion protein; D008466:Mechlorethamine; D014750:Vincristine; D005047:Etoposide; D003606:Dacarbazine; D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin; D007069:Ifosfamide