title: Chemical synthesis of RNA including 5-taurinomethyluridine and 5-taurinomethyl-2-thiouridine.
abstract: Recently, novel base-modified uridine derivatives, 5-taurinomethyluridine (tau m(5)U) and 5-taurinomethyl-2-thiouridine (tau m(5)s(2)U) have been discovered from mammalian mitochondrial tRNAs, and these modified ribonucleosides were found to exist at the first position of the anticodon. We herein report efficient reactions for the synthesis of RNA oligomers including these base-modified ribonucleosides.
authors.affiliation: Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The Universitiy of Tokyo, Kashiwa, Chiba 277-8562, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Ogata
authors.forename: Takeshi
authors.initials: T
authors.lastname: Wada
mesh_terms: D000577:Amides / Q000737:chemistry; D009843:Oligoribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D010756:Phosphoric Acids / Q000737:chemistry; D012313:RNA / Q000138:chemical synthesis; D013891:Thiouridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D014529:Uridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: C540247:5-taurinomethyl-2-thiouridine; C522070:5-taurinomethyluridine; D000577:Amides; D009843:Oligoribonucleotides; D010756:Phosphoric Acids; D013891:Thiouridine; D012313:RNA; C011067:phosphoramidic acid; D014529:Uridine