title: Coexistence of T-cell lymphoblastic lymphoma and myelodysplastic syndrome in a child.
abstract: A 10-year-old girl presented with T-cell lymphoblastic lymphoma of the mediastinum coexisting with myelodysplastic syndrome. Bone marrow examination showed trilineage dysplasia with no evidence of lymphoma cells. Intensive chemotherapy led to a marked reduction in the mediastinal tumor, but no improvement in bone marrow findings. Unrelated cord blood transplantation was performed, resulting in completely chimeric bone marrow cells. A possible explanation for the simultaneous presentation of T-cell lymphoblastic lymphoma and myelodysplastic syndrome is that transformation occurs in pluripotent stem cells differentiating into myeloid and lymphoid cells.
authors.affiliation: Department of Pediatrics, Seirei Hamamatsu General Hospital, Hamamatsu, Shizuoka, Japan. matr@sis.seirei.or.jp
authors.forename: Tadashi
authors.initials: T
authors.lastname: Matsubayashi
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Ohro
authors.forename: Tomoihiro
authors.initials: T
authors.lastname: Yagyuu
authors.forename: Jun
authors.initials: J
authors.lastname: Miyahara
mesh_terms: D001856:Bone Marrow Examination; D002471:Cell Transformation, Neoplastic; D002648:Child; D036101:Cord Blood Stem Cell Transplantation; D005260:Female; D006801:Humans; D016399:Lymphoma, T-Cell / Q000150:complications* / Q000473:pathology; D008479:Mediastinal Neoplasms / Q000150:complications* / Q000473:pathology; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000473:pathology