title: Effects of cypermethrin on some clinico-hemato-biochemical and pathological parameters in male dwarf goats (Capra hircus).
abstract: This study was carried out on 30 dwarf bucks to determine the effects of cypermethrin (CY) on clinical, hemato-biochemical and histopathological parameters. Animals were divided randomly into five equal groups, and each group was dipped in 0%, 0.1%, 0.4%, 0.8% or 1.6% CY, on days 0 and 15. Animals were monitored for clinical signs. Blood and serum samples were collected on day 0 and then fortnightly till day 75. Severe clinical signs comprising itching, restlessness, salivation, skin scratching and head shaking appeared at high doses (0.8% and 1.6% CY). Erythrocyte counts, hemoglobin, hematocrit, total protein, globulin and fibrinogen decreased significantly while total leukocyte counts, alanine aminotransferase and aspartate aminotransferase concentration increased significantly in all the treated groups. In the liver, necrosis of hepatocytes along with cytoplasmic vacuolation and fibroblasts proliferation were observed at a high dose of CY (1.6%). Microscopically kidneys showed congestion of parenchyma and condensation of epithelial cells of tubules along with deposition of casts in tubules. Shrinkage of glomerular capillaries and increased urinary spaces were pronounced in the high-dose group. Lungs exhibited accumulation of fibrinous exudation, thickening of alveolar walls, collapse and broken alveoli in animals treated with a high dose of CY. It was concluded that CY caused dose-dependent effects on all parameters studied. High doses of CY (0.8% and 1.6% solution) affected the parameters on erythrocytes and leukocytes for whole evaluation period, while effects on plasma proteins were transient and on ALT, AST and fibrinogen were transient but lasted a few weeks longer.
authors.affiliation: Department of Veterinary Pathology, University of Agriculture, Faisalabad, Pakistan. ahrar1122@yahoo.com
authors.forename: Ahrar
authors.initials: A
authors.lastname: Khan
authors.forename: Hafiz A M
authors.initials: HA
authors.lastname: Faridi
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ali
authors.forename: Muhammad Zargham
authors.initials: MZ
authors.lastname: Khan
authors.forename: Muhammad
authors.initials: M
authors.lastname: Siddique
authors.forename: Iftikhar
authors.initials: I
authors.lastname: Hussain
authors.forename: Maqbool
authors.initials: M
authors.lastname: Ahmad
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006041:Goats / Q000097:blood* / Q000254:growth & development / Q000378:metabolism*; D007306:Insecticides / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008297:Male; D009928:Organ Specificity; D011722:Pyrethrins / Q000633:toxicity*; D018675:Toxicity Tests / Q000379:methods
chemical_list: D007306:Insecticides; D011722:Pyrethrins; C017160:cypermethrin