[HLA-DM polymorphisms in Guizhou Han individuals].
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to determine genetic polymorphisms at HLA-DMA/DMB loci in 125 healthy unrelated Han individuals from Guizhou Province. We found that the frequencies of DMA*0101, DMA*0102, and DMA*0103 alleles were 0.720, 0.242, and 0.036, respectively. The frequencies of DMB*0101, DMB*0102, DMB*0103, and DMB*0104 alleles were 0.620, 0.156, 0.188, and 0.036, respectively. Common genotypes for DMA were DMA*0101/0101 and 0101/0102. Common genotypes for DMB were DMB*0101/0101, 0101/0102, and 0101/0103. These results showed that the genetic polymorphism of HLA-DM gene in Han individuals from Guizhou Province is distinct from other regions.
Jiang
Hong-Mei
HM
Department of Clinical Microbiology and Immunology, Guiyang Medical College, Guiyang 550004, China. jhmzq@yahoo.com.cn
Wang
Yong-Xia
YX
Wang
Yong
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D002681:China / Q000208:ethnology; D005260:Female; D006681:HLA-D Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D055815:Young Adult
D006681:HLA-D Antigens; C084245:HLA-DM antigens