title: Design of a potential colonic drug delivery system of mesalamine.
abstract: The aim of the present investigation was to develop a site-specific colonic drug delivery system, built on the principles of the combination of pH and time sensitivity. Press-coated mesalamine tablets with a coat of HPMC E-15 were over-coated with Eudragit S100. The in vitro drug release study was conducted using sequential dissolution technique at pH 1.2, 6.0, 7.2 and 6.4 mimicking different regions of gastrointestinal tract. The optimized batch (F2) showed less than 6% of drug release before reaching colonic pH 6.4 and complete drug release was obtained thereafter within 2 hr. A short-term dissolution stability study demonstrated statistical insignificant difference in drug release.
authors.affiliation: Department of Pharmaceutics and Pharmaceutical Technology, L.M. College of Pharmacy, Ahmedabad, India. mukeshgohel@hotmail.com
authors.forename: Mukesh C
authors.initials: MC
authors.lastname: Gohel
authors.forename: Rajesh K
authors.initials: RK
authors.lastname: Parikh
authors.forename: Stavan A
authors.initials: SA
authors.lastname: Nagori
authors.forename: Mahesh R
authors.initials: MR
authors.lastname: Dabhi
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D002626:Chemistry, Pharmaceutical; D003106:Colon / Q000378:metabolism*; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D006863:Hydrogen-Ion Concentration; D065347:Hypromellose Derivatives; D019804:Mesalamine / Q000008:administration & dosage*; D008747:Methylcellulose / Q000031:analogs & derivatives; D011109:Polymethacrylic Acids / Q000737:chemistry; D012995:Solubility; D013607:Tablets; D013997:Time Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D011109:Polymethacrylic Acids; D013607:Tablets; C038300:methylmethacrylate-methacrylic acid copolymer; D065347:Hypromellose Derivatives; D019804:Mesalamine; D008747:Methylcellulose