title: Nucleic acid duplexes with zippers of additional nucleobases and aromatics in minor or major groove.
abstract: Two series of thymidine derivatives with additional nucleobases/aromatics attached to either the 5'(S)-C- or the 5-position were prepared by epoxide opening and/or "click chemistry" cycloaddition protocols and introduced into DNA duplexes. Interstrand base-base communication in the minor groove and intrastrand stacking interactions in the major groove were detected.
authors.affiliation: Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, 5230 Odense M, Denmark. pon@ifk.sdu.dk
authors.forename: Poul
authors.initials: P
authors.lastname: Nielsen
authors.forename: Khalil I
authors.initials: KI
authors.lastname: Shaikh
authors.forename: Lise J
authors.initials: LJ
authors.lastname: Nielsen
authors.forename: Nicolai K
authors.initials: NK
authors.lastname: Andersen
authors.forename: Lucie
authors.initials: L
authors.lastname: Spácilová
authors.forename: Henrik
authors.initials: H
authors.lastname: Nielsen
authors.forename: Petr
authors.initials: P
authors.lastname: Kocalka
authors.forename: Mikkel S
authors.initials: MS
authors.lastname: Christensen
mesh_terms: D004247:DNA / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis / Q000737:chemistry; D013696:Temperature; D013936:Thymidine / Q000031:analogs & derivatives*; D014230:Triazoles / Q000737:chemistry
chemical_list: D011741:Pyrimidine Nucleosides; D014230:Triazoles; D004247:DNA; D013936:Thymidine