Site-specific modification by functionality-transfer oligonucleotide with the photo-inducible reactivity.
Previously, we reported that S-vinyl thioguanosine analogs exhibited the efficient functionality-transfer reaction with selectivity toward cytidine. This technique was applied to the inhibition and the labelling of DNA or RNA. In this study, we aimed at developing functionality-transfer oligonucleotide with the photo-inducible reactivity. This photo-induced transfer reaction proceeded only to d(m)C but not to dC and dT at the target site of the complementary ODN.
Onizuka
Kazumitsu
K
Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Taniguchi
Yosuke
Y
Nishioka
Takamasa
T
Sasaki
Shigeki
S
D002851:Chromatography, High Pressure Liquid; D003841:Deoxycytidine / Q000737:chemistry; D009841:Oligonucleotides / Q000737:chemistry* / Q000528:radiation effects; D055668:Photochemical Processes; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013872:Thionucleosides / Q000737:chemistry; D014753:Vinyl Compounds / Q000737:chemistry*
D009841:Oligonucleotides; D013872:Thionucleosides; D014753:Vinyl Compounds; D003841:Deoxycytidine