title: Metabolism and the paradoxical effects of arsenic: carcinogenesis and anticancer.
abstract: Arsenic, a known human carcinogen, can induce tumors of the skin, urinary bladder, liver and lung etc.. On the other hand, arsenic is also a novel promising anticancer agent, and can be used effectively to treat acute promyelocytic leukemia (APL) and some other tumors. These paradoxical effects of arsenic not only result from direct or indirect influences on the genetic and epigenetic levels, but are also closely correlated with unique arsenic metabolism. This article reviews our recent studies as well as other reports on arsenic metabolism and epigenetic changes of DNA methylation during its metabolism. We also summarize the clinical use of arsenic trioxide (As2O3) to date and discuss new therapeutic strategies such as concurrent arsenic-radiation therapy to achieve local tumor control and enhance the radiosensitivity of solid tumors.
authors.affiliation: Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Chiba 263-8555, Japan. saisei@nirs.go.jp
authors.forename: Xing
authors.initials: X
authors.lastname: Cui
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Makoto
authors.initials: M
authors.lastname: Akashi
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Okayasu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity*; D001151:Arsenic / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity*; D002273:Carcinogens / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity*; D006801:Humans
chemical_list: D000970:Antineoplastic Agents; D002273:Carcinogens; D001151:Arsenic