title: Primary multifocal osseous lymphoma in a child.
abstract: We report a case of primary multifocal osseous lymphoma in a 6-year-old girl presenting with multifocal osteolytic lesions without systemic symptoms or identifiable non-osseous primary tumor. The differential diagnoses for such a presentation include histiocytosis X, chronic recurrent multifocal osteomyelitis, acute lymphoblastic leukemia, metastatic disease, and primary bone lymphoma. Although non-Hodgkin lymphoma is common in the pediatric population, its presentation as a primary bone tumor, especially with multifocal disease, is extremely rare and is frequently misdiagnosed. We hope that awareness of this entity will help radiologists achieve timely diagnosis and intervention.
authors.affiliation: Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
authors.forename: Takashi S P
authors.initials: TS
authors.lastname: Sato
authors.forename: Polly J
authors.initials: PJ
authors.lastname: Ferguson
authors.forename: Geetika
authors.initials: G
authors.lastname: Khanna
mesh_terms: D018771:Arthralgia / Q000209:etiology; D001706:Biopsy / Q000379:methods; D001859:Bone Neoplasms / Q000150:complications / Q000175:diagnosis*; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging / Q000473:pathology; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals; D035583:Rare Diseases; D014057:Tomography, X-Ray Computed; D051598:Whole Body Imaging / Q000379:methods
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
references.citation: J Clin Oncol. 1989 Sep;7(9):1275-80
references.pmid: 2769328
references.citation: Radiographics. 2003 Nov-Dec;23(6):1371-83; discussion 1384-7
references.pmid: 14615550
references.citation: Am J Surg Pathol. 2000 Nov;24(11):1480-90
references.pmid: 11075849
references.citation: Am J Surg Pathol. 1998 Jul;22(7):795-804
references.pmid: 9669342
references.citation: Am J Clin Pathol. 2001 Jun;115(6):868-75
references.pmid: 11392884
references.citation: Skeletal Radiol. 1997 Jan;26(1):35-41
references.pmid: 9040141
references.citation: Am J Clin Pathol. 1999 Dec;112(6):836-43
references.pmid: 10587707
references.citation: J Bone Joint Surg Am. 2006 Mar;88(3):583-94
references.pmid: 16510826