title: Intra-individual crossover comparison of gadobenate dimeglumine and gadopentetate dimeglumine for contrast-enhanced magnetic resonance angiography of the supraaortic vessels at 3 Tesla.
abstract: OBJECTIVE
  To compare gadobenate dimeglumine (Gd-BOPTA) and gadopentetate dimeglumine (Gd-DTPA) for contrast-enhanced magnetic resonance (MR) angiography of the supraaortic vessels at 3 Tesla.
  
  
  METHODS
  Twelve healthy volunteers each underwent two contrast-enhanced magnetic resonance angiography examinations, one with Gd-BOPTA and one with Gd-DTPA each at a dose of 0.1 mmol/kg bodyweight. The 2 examinations were performed in randomized order and were separated by at least 72 hours. Imaging was performed in the coronal plane at 3T (Magnetom TIM Trio Siemens) using a 12-channel neurovascular array coil. The MR sequence parameters were identical for all examinations. Maximum intensity projection reconstructions were evaluated separately and in matched-pairs by a single independent blinded reviewer in terms of qualitative (5-point scales for technical quality and vessel delineation) and quantitative (relative contrast-to-noise ratio) contrast enhancement across 19 arteries/arterial segments comprising the internal carotid arteries; anterior, middle, and posterior cerebral arteries; vertebral arteries; and basilar artery. Findings were compared using the Wilcoxon signed rank test.
  
  
  RESULTS
  The mean technical quality across all examinations was significantly (P = 0.031) greater after Gd-BOPTA. The overall median score for vessel delineation was also significantly higher for Gd-BOPTA than for Gd-DTPA (4.3 vs. 3.7; P = 0.005). Matched-pairs assessment revealed significant (P <or= 0.026) preference for Gd-BOPTA both globally and for assessments of the extracranial arteries, Circle of Willis and vessels distal to the Circle of Willis. The relative contrast-to-noise ratio was significantly (P <or= 0.021) greater after Gd-BOPTA, with overall increases of 23.3%, 26.7%, and 28.5% noted for the internal carotid, middle cerebral, and basilar arteries, respectively.
  
  
  CONCLUSIONS
  Significantly improved image quality and contrast enhancement is achieved at 3T with 0.1 mmol/kg Gd-BOPTA compared with 0.1 mmol/kg Gd-DTPA.
authors.affiliation: Department of Neuroradiology, University Hospital of Tübingen, Tübingen, Germany. Bueltmann.eva@mh-hannover.de
authors.forename: Eva
authors.initials: E
authors.lastname: Bueltmann
authors.forename: Gunter
authors.initials: G
authors.lastname: Erb
authors.forename: Miles A
authors.initials: MA
authors.lastname: Kirchin
authors.forename: Uwe
authors.initials: U
authors.lastname: Klose
authors.forename: Thomas
authors.initials: T
authors.lastname: Naegele
mesh_terms: D000293:Adolescent; D000328:Adult; D001011:Aorta / Q000502:physiology*; D003287:Contrast Media; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000295:instrumentation* / Q000379:methods; D008297:Male; D008536:Meglumine / Q000031:analogs & derivatives*; D009942:Organometallic Compounds; D055815:Young Adult
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine; D019786:Gadolinium DTPA