title: Structure-based optimization of protein tyrosine phosphatase-1 B inhibitors: capturing interactions with arginine 24.
authors.affiliation: Chemical and Screening Sciences, Wyeth Research, 200 Cambridgepark Drive, Cambridge, MA 02140, USA.
authors.forename: Zhao-Kui
authors.initials: ZK
authors.lastname: Wan
authors.forename: Jinbo
authors.initials: J
authors.lastname: Lee
authors.forename: Rajeev
authors.initials: R
authors.lastname: Hotchandani
authors.forename: Alessandro
authors.initials: A
authors.lastname: Moretto
authors.forename: Eva
authors.initials: E
authors.lastname: Binnun
authors.forename: Douglas P
authors.initials: DP
authors.lastname: Wilson
authors.forename: Steve J
authors.initials: SJ
authors.lastname: Kirincich
authors.forename: Bruce C
authors.initials: BC
authors.lastname: Follows
authors.forename: Manus
authors.initials: M
authors.lastname: Ipek
authors.forename: Weixin
authors.initials: W
authors.lastname: Xu
authors.forename: Diane
authors.initials: D
authors.lastname: Joseph-McCarthy
authors.forename: Yan-Ling
authors.initials: YL
authors.lastname: Zhang
authors.forename: May
authors.initials: M
authors.lastname: Tam
authors.forename: David V
authors.initials: DV
authors.lastname: Erbe
authors.forename: James F
authors.initials: JF
authors.lastname: Tobin
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Steve Y
authors.initials: SY
authors.lastname: Tam
authors.forename: Tarek S
authors.initials: TS
authors.lastname: Mansour
authors.forename: Junjun
authors.initials: J
authors.lastname: Wu
mesh_terms: D001120:Arginine / Q000737:chemistry*; D018360:Crystallography, X-Ray; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors* / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D001120:Arginine; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1