E-box protein E2-2 is a crucial regulator of plasmacytoid DC development.
DC play central roles in priming both innate and adaptive immune responses. Multiple DC subsets have been identified on the basis of their phenotype and function. Plasmacytoid DC (pDC) are professional IFN-producing cells that play an essential role in anti-viral immunity. A series of recent studies demonstrates that the regulation of pDC development is different from other types of DC. In this issue of the European Journal of Immunology, new insight is provided into how human pDC development is regulated by various transcription factors, in particular by the Ets family protein Spi-B and E-box protein E2-2.
Esashi
Eiji
E
Department of Immunology and Center for Cancer Immunology Research, University of Texas, M. D. Anderson Cancer Center, Houston, TX 77030, USA. eesashi@mdanderson.org
Liu
Yong-Jun
YJ
D004268:DNA-Binding Proteins / Q000378:metabolism*; D003713:Dendritic Cells / Q000166:cytology* / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism; D051820:TCF Transcription Factors / Q000378:metabolism*; D058118:Transcription Factor 7-Like 2 Protein; D014157:Transcription Factors / Q000378:metabolism*
D004268:DNA-Binding Proteins; D051820:TCF Transcription Factors; C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein; D014157:Transcription Factors; C076877:SPIB protein, human
J Exp Med. 2002 Dec 2;196(11):1415-25
12461077
Blood. 2000 Jan 1;95(1):138-46
10607696
Blood. 2000 Feb 1;95(3):879-85
10648399
J Exp Med. 2000 Jul 17;192(2):219-26
10899908
Mol Cell Biol. 1996 Jun;16(6):2898-905
8649400
Immunity. 2003 Dec;19(6):903-12
14670306
J Exp Med. 2000 Dec 18;192(12):1775-84
11120774
J Exp Med. 2004 Dec 6;200(11):1503-9
15583020
Immunity. 2007 Jun;26(6):741-50
17582346
Immunity. 2008 Apr;28(4):490-2
18400192
J Immunol. 2000 Feb 15;164(4):1855-61
10657634
J Immunol. 2005 Mar 1;174(5):2573-81
15728463
J Exp Med. 1996 Nov 1;184(5):1953-62
8920882
J Immunol. 2000 Jul 1;165(1):566-72
10861097
Annu Rev Immunol. 2005;23:275-306
15771572
Cell. 2005 Apr 22;121(2):295-306
15851035
Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8981-6
15184678
Eur J Immunol. 2008 Sep;38(9):2389-400
18792017
Blood. 2000 Nov 1;96(9):3029-39
11049981
Blood. 2004 Nov 1;104(9):2849-57
15242870
Immunity. 2008 Apr;28(4):509-20
18342552
J Exp Med. 2006 Jan 23;203(1):227-38
16418395