title: [Preoperative evaluation of liver function using 99mTc-diethyl iminodiacetic acid based on single photon emission computed tomography].
abstract: OBJECTIVE
  To establish a three-dimentional liver function evaluation system using 99mTc-diethyl iminodiacetic acid (99mTc-EHIDA) scintigraphy based on single photon emission computed tomography (SPECT).
  
  
  METHODS
  Totally 16 patients with liver lesions were divided into cirrhosis group and non-cirrhosis group. SPECT was performed 2 days before operation and 5 days after operation. Serum liver functions were examined on the same day of scintigraphy. SPECT images of areas of interest of heart and liver were aquired. Time of the peak of EHIDA density in liver (Tpeak), five-minutes heart liver index (HLI5), blood clearance index (HH15), receptor index (LHL15), and the predictive values were calculated.
  
  
  RESULTS
  Tpeak was not significantly different between two groups, while HLI5, HH15, and LHL15 were significantly different (P = 0.033, P = 0.001, and P = 0.005). HLI, and LHL15 were significantly correlated with preoperative total protein and prealbumin levels (P = 0.003, P = 0.015, P = 0.022, P = 0.038) and post-operative prealbumin (P = 0.037, P = 0.042). The predictive values of HLI5 and LHL15 correlated well with postoperative HLI5 and LHL15 (r = 0.675, P = 0.016; r = 0.629, P = 0.028).
  
  
  CONCLUSIONS
  The three-dimentional liver function evaluation system using 99mTc-EHIDA based on liver SPECT may facilitate the further studies of risks of liver surgery.
authors.affiliation: Department of Liver Surgery, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors.forename: Shun-da
authors.initials: SD
authors.lastname: Du
authors.forename: Yi-lei
authors.initials: YL
authors.lastname: Mao
authors.forename: Fang
authors.initials: F
authors.lastname: Li
authors.forename: Meng
authors.initials: M
authors.lastname: Ouyang
authors.forename: Jun-xiang
authors.initials: JX
authors.lastname: Tong
authors.forename: Xin-ting
authors.initials: XT
authors.lastname: Sang
authors.forename: Zhi-ying
authors.initials: ZY
authors.lastname: Yang
authors.forename: Xin
authors.initials: X
authors.lastname: Lu
authors.forename: Tian-yi
authors.initials: TY
authors.lastname: Chi
authors.forename: Hai-tao
authors.initials: HT
authors.lastname: Zhao
authors.forename: Yi-yao
authors.initials: YY
authors.lastname: Xu
authors.forename: Hai-feng
authors.initials: HF
authors.lastname: Xu
authors.forename: Shou-xian
authors.initials: SX
authors.lastname: Zhong
authors.forename: Jie-fu
authors.initials: JF
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D057234:Preoperative Period; D019275:Radiopharmaceuticals / Q000008:administration & dosage*; D019784:Technetium Tc 99m Diethyl-iminodiacetic Acid / Q000008:administration & dosage*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019275:Radiopharmaceuticals; D019784:Technetium Tc 99m Diethyl-iminodiacetic Acid