DNA glue: 1-, 2- and 4-ethynylpyrenes in the structure of twisted intercalating nucleic acids (TINAs), DNA duplexes/triplexes and interstrand excimer formation.
Significant alterations in thermal stability of parallel DNA triplexes and antiparallel duplexes were observed upon changing the attachment of ethynylpyrenes from para to ortho in the structure of phenylmethylglycerol inserted as a bulge into DNA (TINA). Insertions of two ortho-TINAs as a pseudo-pair in the middle of the duplex resulted in formation of an excimer band at 505 nm for both 1- and 4-ethynylpyrene analogues.
Filichev
Vyacheslav V
VV
Institute of Fundamental Sciences, Massey University, Palmerston North, New Zealand. v.filichev@massey.ac.nz
Astakhova
Irina V
IV
Malakhov
Andrei D
AD
Korshun
Vladimir A
VA
Pedersen
Erik B
EB
D004247:DNA / Q000737:chemistry*; D007364:Intercalating Agents / Q000737:chemistry*; D009691:Nucleic Acid Denaturation; D011721:Pyrenes / Q000737:chemistry*; D013696:Temperature
D007364:Intercalating Agents; D011721:Pyrenes; C051802:triplex DNA; D004247:DNA