Coordinating development of medullary thymic epithelial cells.
Three papers in this issue of Immunity (Akiyama et al., 2008; Hikosaka et al., 2008; Irla et al., 2008) together reveal coordinating roles for autoreactive T cells and TNF receptor superfamily members in the development of medullary thymic epithelial cells.
Zhu
Mingzhao
M
The Department of Pathology and Committee on Immunology, The University of Chicago, Chicago, IL 60637, USA.
Fu
Yang-Xin
YX
D000818:Animals; D015551:Autoimmunity; D019013:CD40 Antigens / Q000378:metabolism; D023201:CD40 Ligand / Q000378:metabolism; D004847:Epithelial Cells / Q000166:cytology / Q000276:immunology*; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D053245:RANK Ligand / Q000378:metabolism; D053246:Receptor Activator of Nuclear Factor-kappa B / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D017634:Self Tolerance; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology* / Q000502:physiology; D014157:Transcription Factors / Q000378:metabolism; D000096927:AIRE Protein
D019013:CD40 Antigens; D023201:CD40 Ligand; D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B; D011948:Receptors, Antigen, T-Cell; D014157:Transcription Factors; D000096927:AIRE Protein