Identifying genetic components of drug response in mice.
Individual variations in drug response are crucial factors in both the development and deployment of therapy, yet we are still woefully ignorant of the majority of this genetic basis. Here we discuss the convergence of genetics and genomics to dissect such pharmacological variation, with emphasis on satisfying the requirements of both genetics and pharmacology itself, the appropriate use of model organisms and the often overlooked power of genetic dissection to inform understanding of physiological process.
Cotsapas
Chris
C
Center for Human Genetic Research, Massachusetts General Hospital, MA, USA. chrisc@chgr.mgh.harvard.edu
D000818:Animals; D004351:Drug Resistance / Q000187:drug effects / Q000235:genetics*; D014644:Genetic Variation / Q000187:drug effects / Q000235:genetics*; D023281:Genomics / Q000379:methods* / Q000639:trends; D006801:Humans; D051379:Mice; D023421:Models, Animal; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*
D004364:Pharmaceutical Preparations