title: Trends in large-scale mouse mutagenesis: from genetics to functional genomics.
abstract: The primary goal of mouse mutagenesis programmes is to develop a fundamental research infrastructure for mammalian functional genomics and to produce human disease models. Many large-scale programmes have been ongoing since 1997; these culminated in the International Knockout Mouse Consortium (IKMC) in 2007 with the aim to establish knockout and conditional mouse strains for all mouse genes. This article traces the origins and rationale of these large-scale mouse mutagenesis programmes.
authors.affiliation: Mutagenesis and Genomics Team, RIKEN BioResource Center, 3-1-1 Koyadai, Tsukuba, Ibaraki, Japan. gondo@brc.riken.jp
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Gondo
mesh_terms: D000818:Animals; D030541:Databases, Genetic; D004195:Disease Models, Animal; D005038:Ethylnitrosourea; D023281:Genomics / Q000379:methods / Q000639:trends*; D051379:Mice / Q000235:genetics*; D008822:Mice, Transgenic; D008954:Models, Biological; D016296:Mutagenesis / Q000502:physiology*; D009369:Neoplasms / Q000139:chemically induced / Q000235:genetics
chemical_list: D005038:Ethylnitrosourea