Synthesis and study of 9-deazaguanosine derivatives as potential inhibitors of RNA virus replication.
9-Deazaguanosine and the alpha and beta anomers of its 2'-C-methyl counter part, have been synthesized and evaluated against a broad range of RNA viruses, including hepatitis C virus.
Hamann
Marie
M
Idenix Pharmaceuticals, Medicinal Chemistry Laboratory, Cap Gamma 1682 rue de la Valsière, 34189 Montpellier Cedex 4, France.
Pierra
Claire
C
Storer
Richard
R
Sommadossi
Jean-Pierre
JP
Loi
Anna Giulia
AG
Cadeddu
Alessandra
A
Fanti
Maura
M
Boscu
Nadia
N
Bassetti
Fabiola
F
Liuzzi
Michel
M
Gosselin
Gilles
G
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005416:Flavivirus / Q000187:drug effects; D006151:Guanosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D016174:Hepacivirus / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects
C541634:9-deazaguanosine; D000998:Antiviral Agents; D006151:Guanosine