title: Comparison of photopic negative responses elicited by red and white xenon flashes in monkeys.
abstract: OBJECTIVE
  The photopic negative response (PhNR) is a negative component of the photopic electroretinogram (ERG), and is believed to originate mainly from the retinal ganglion cells. The PhNR is commonly elicited by red light-emitting diodes. The purpose of this study was to compare the amplitude of the PhNR elicited in monkeys by red stimuli and white stimuli obtained from a xenon light source.
  
  
  METHODS
  The PhNRs were elicited from six rhesus monkeys by photopically matched red and white xenon flashes (peak output, 600 nm) on a rod-saturating blue background. The amplitudes of the PhNR elicited by white flashes were compared with those elicited by the red flashes before and after the intravitreal injection of tetrodotoxin (TTX).
  
  
  RESULTS
  The differences in PhNR amplitudes between the red and white stimuli, and the changes in the PhNR amplitudes after the injection of TTX, were not statistically significant.
  
  
  CONCLUSIONS
  These results suggest that red and white xenon flashes are of approximately equal value for assessing inner retinal function using the PhNR under our recording conditions.
authors.affiliation: Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Miyata
authors.affiliation: Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan. ueno@med.nagoya-u.ac.jp.
authors.forename: Shinji
authors.initials: S
authors.lastname: Ueno
authors.affiliation: Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Mineo
authors.initials: M
authors.lastname: Kondo
authors.affiliation: Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Koyasu
authors.affiliation: Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Terasaki
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004596:Electroretinography; D008253:Macaca mulatta; D010775:Photic Stimulation; D012160:Retina / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D012165:Retinal Ganglion Cells / Q000502:physiology; D026941:Sodium Channel Blockers / Q000008:administration & dosage; D013779:Tetrodotoxin / Q000008:administration & dosage; D014978:Xenon
chemical_list: D026941:Sodium Channel Blockers; D014978:Xenon; D013779:Tetrodotoxin
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