Neonatal pemphigus vulgaris.
A male newborn with skin erosions was born to a 32-year-old woman who was under treatment for pemphigus vulgaris that had been diagnosed 16 months earlier. Antibodies to desmoglein (Dsg)1 and Dsg3 were analyzed by enzyme-linked immunosorbent assay. Index values of antibodies to Dsg1 and Dsg3 were 49 (normal index values, <14) and 121 (normal index values, <7), respectively. Those findings concluded a diagnosis of neonatal pemphigus vulgaris. No new vesicles or bullae appeared in the newborn after the birth. Non-corticosteroid ointments produced prompt epithelialization on the erosive lesions. All the eruptions disappeared in 3 weeks. The level of serum anti-Dsg3 autoantibodies when measured at the 76th day was negative (<5).
Gushi
Makiko
M
Division of Dermatology, Department of Organ-oriented Medicine, School of Medicine, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan. mgusi@yuuai.info
Yamamoto
Yu-Ichi
Y
Mine
Yoshiko
Y
Awazawa
Ryoko
R
Nonaka
Kimiko
K
Taira
Kiyohito
K
Asato
Yutaka
Y
Hagiwara
Keisuke
K
Uezato
Hiroshi
H
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D001323:Autoantibodies / Q000097:blood; D015415:Biomarkers / Q000097:blood; D051183:Desmoglein 1 / Q000276:immunology; D051184:Desmoglein 3 / Q000276:immunology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010392:Pemphigus / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D011247:Pregnancy; D011248:Pregnancy Complications; D012867:Skin / Q000473:pathology; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D001323:Autoantibodies; D015415:Biomarkers; C495297:DSG1 protein, human; C071894:DSG3 protein, human; D051183:Desmoglein 1; D051184:Desmoglein 3