title: Long-term antireflux medication use following pediatric Nissen fundoplication.
abstract: OBJECTIVE
  Nissen fundoplication decreases the use of antireflux medications.
  
  
  METHODS
  Retrospective cohort study using discharge abstract data and pharmacy data.
  
  
  METHODS
  Twelve regional Kaiser Permanente hospitals in southern California.
  
  
  METHODS
  Three hundred forty-two patients underwent Nissen fundoplication.
  
  
  METHODS
  Nissen fundoplication.
  
  
  METHODS
  Use of antireflux medications.
  
  
  RESULTS
  The number of patients requiring antireflux medications decreased from 233 patients (68.1%) before Nissen fundoplication to 197 (57.6%) after Nissen fundoplication. Of the 233 patients, 176 (75.6%) were restarted on antireflux medications within 1 year after Nissen fundoplication. Use of antireflux medication decreased in neurologically healthy patients but was unchanged in neurologically impaired children.
  
  
  CONCLUSIONS
  Use of antireflux medication decreased after Nissen fundoplication. Neurologically healthy children showed the biggest decrease in antireflux medication use after Nissen fundoplication.
authors.affiliation: Division of Pediatric Surgery, Kaiser Permanente, Los Angeles Medical Center, 4760 Sunset Blvd, Third Floor, Los Angeles, CA 90027, USA. slleemd@yahoo.com
authors.forename: Steven L
authors.initials: SL
authors.lastname: Lee
authors.forename: Roman M
authors.initials: RM
authors.lastname: Sydorak
authors.forename: Vicki Y
authors.initials: VY
authors.lastname: Chiu
authors.forename: Jin-Wen
authors.initials: JW
authors.lastname: Hsu
authors.forename: Harry
authors.initials: H
authors.lastname: Applebaum
authors.forename: Philip I
authors.initials: PI
authors.lastname: Haigh
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D018662:Fundoplication; D005764:Gastroesophageal Reflux / Q000517:prevention & control* / Q000601:surgery; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D008297:Male; D054328:Proton Pump Inhibitors / Q000008:administration & dosage*
chemical_list: D054328:Proton Pump Inhibitors