Role of IGF-1 in glucose regulation and cardiovascular disease.
IGF-1 is a peptide hormone that is expressed in most tissues. It shares significant structural and functional similarities with insulin, and is implicated in the pathogenesis of insulin resistance and cardiovascular disease. Recombinant human IGF-1 has been used in Type 2 diabetes to improve insulin sensitivity and aid glycemic control. There is evidence supporting IGF-1 as a vascular protective factor and it may also be beneficial in the treatment of chronic heart failure. Further understanding of the effects of IGF-1 signaling in health and disease may lead to novel approaches to the prevention and treatment of diabetes and cardiovascular disease.
Abbas
Afroze
A
BHF Clinical Research Fellow, Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK. a.abbas@leeds.ac.uk
Grant
Peter J
PJ
Kearney
Mark T
MT
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D050197:Atherosclerosis / Q000503:physiopathology; D001786:Blood Glucose / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000097:blood* / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000097:blood / Q000503:physiopathology* / Q000517:prevention & control; D004730:Endothelium, Vascular / Q000503:physiopathology; D013006:Growth Hormone / Q000502:physiology; D006333:Heart Failure / Q000188:drug therapy; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000502:physiology; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D020928:Mitogen-Activated Protein Kinases / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000502:physiology; D032383:Myocytes, Cardiac / Q000502:physiology; D010179:Pancreas / Q000503:physiopathology; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D017526:Receptor, IGF Type 1 / Q000502:physiology; D013234:Stem Cells / Q000502:physiology
D001786:Blood Glucose; C032231:IGFBP1 protein, human; D018970:Insulin-Like Growth Factor Binding Protein 1; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D019869:Phosphatidylinositol 3-Kinases; D017526:Receptor, IGF Type 1; D020928:Mitogen-Activated Protein Kinases