Hydrolysis of single linkage in long DNA using oligonucleotide-multiphosphonate conjugates and Ce IV/EDTA.
Only one phosphodiester linkage in long DNA was hydrolyzed simply by using two components: oligonucleotide-multiphosphonate conjugates ("gapmers") and Ce(IV)/EDTA (Fig. 1).
Suzuki
Yuta
Y
Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, 153-8904, Japan.
Lönnberg
Tuomas
T
Komiyama
Makoto
M
D002563:Cerium / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D004492:Edetic Acid / Q000737:chemistry*; D005029:Ethylenediamines / Q000737:chemistry*; D006868:Hydrolysis; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D063065:Organophosphonates / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000737:chemistry*
D005029:Ethylenediamines; D009841:Oligonucleotides; D063065:Organophosphonates; D009943:Organophosphorus Compounds; C418473:ethylenediaminetetrakis(methylphosphonic) acid; C041182:(nitrilotris(methylene))triphosphonic acid; D002563:Cerium; D004247:DNA; D004492:Edetic Acid