title: Antifungal cyclic depsipeptide, eujavanicin A, isolated from Eupenicillium javanicum.
abstract: In the course of searching for new antifungal agents, a new cyclic depsipeptide, eujavanicin A (1), was isolated from Eupenicillium javanicum as an antifungal agent against the human pathogenic filamentous fungus Aspergillus fumigatus. The structure of 1 was established by spectroscopic and chemical investigations. The absolute stereochemistry was elucidated by Marfey's method and by chiral HPLC analysis.
authors.affiliation: School of Pharmaceutical Sciences, Ohu University, Misumido 31-1, Tomita-machi, Koriyama, Fukushima 963-8611, Japan.
authors.forename: Shou
authors.initials: S
authors.lastname: Nakadate
authors.forename: Koohei
authors.initials: K
authors.lastname: Nozawa
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Sato
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Horie
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Fujii
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nagai
authors.forename: Tomoo
authors.initials: T
authors.lastname: Hosoe
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Kawai
authors.forename: Takashi
authors.initials: T
authors.lastname: Yaguchi
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects*; D001412:Bacillus subtilis / Q000187:drug effects; D047630:Depsipeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D007564:Japan; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012477:Salmonella enteritidis / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D047630:Depsipeptides; C532732:eujavanicin A