Regulation of Wilms' tumor gene expression by nerve growth factor and follicle-stimulating hormone in the immature mouse ovary.
This study investigated the regulation of Wilms' tumor gene (WT1) in the ovary by nerve growth factor and FSH to better understand signals that initiate early follicular growth. Nerve growth factor showed a direct stimulatory effect on endogenous expression of WT1, whereas FSH attenuated basal and nerve growth factor-stimulated WT1 protein expression, which most likely depended on FSH responsiveness according to the follicle growth stage.
Roh
Jaesook
J
Department of Obstetrics & Gynecology, Hanyang Medical University, Seoul, Korea. rohjaesook@hanyang.ac.kr
Bae
Jeehyeon
J
Lee
Kangseok
K
Mayo
Kelly
K
Shea
Lonnie
L
Woodruff
Teresa K
TK
D000375:Aging / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002460:Cell Line; D002478:Cells, Cultured; D005260:Female; D005640:Follicle Stimulating Hormone / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects* / Q000502:physiology; D016162:Genes, Wilms Tumor / Q000502:physiology*; D006107:Granulosa Cells / Q000166:cytology / Q000502:physiology; D051379:Mice; D023421:Models, Animal; D020932:Nerve Growth Factor / Q000494:pharmacology*; D006080:Ovarian Follicle / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D010053:Ovary / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D025721:WT1 Proteins / Q000235:genetics / Q000378:metabolism*
D025721:WT1 Proteins; D005640:Follicle Stimulating Hormone; D020932:Nerve Growth Factor
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