title: Taumycins A and B, two bioactive lipodepsipeptides from the Madagascar sponge Fascaplysinopsis sp.
abstract: Two closely related lipodepsipeptides, taumycins A and B (1 and 2) have been isolated from the Madagascar sponge Fascaplysinopsis sp. The two compounds have the same 12-membered oxodepsipeptide ring system in common. Both were toxic to brine shrimp larvae, and taumycin A (1 microM), but not taumycin B, inhibited growth of the human UT-7 leukemic cell line. The structure of the two compounds, likely to be derived from microorganisms, was established by MS and 1D and 2D NMR data.
authors.affiliation: School of Chemistry and Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel.
authors.forename: Ashgan
authors.initials: A
authors.lastname: Bishara
authors.forename: Amira
authors.initials: A
authors.lastname: Rudi
authors.forename: Maurice
authors.initials: M
authors.lastname: Aknin
authors.forename: Drorit
authors.initials: D
authors.lastname: Neumann
authors.forename: Nathalie
authors.initials: N
authors.lastname: Ben-Califa
authors.forename: Yoel
authors.initials: Y
authors.lastname: Kashman
mesh_terms: D000818:Animals; D001156:Artemia / Q000254:growth & development; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D047630:Depsipeptides / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D006801:Humans; D007814:Larva / Q000187:drug effects; D008270:Madagascar; D010455:Peptides / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D011161:Porifera / Q000737:chemistry*
chemical_list: D047630:Depsipeptides; D010455:Peptides; C532773:taumycin A; C532774:taumycin B