title: [Hepar lobatum carcinomatusum: a rare cause of portal hypertension complicating hepatic metastases in breast cancer].
abstract: Hepar lobatum carcinomatosum is an acquired liver dysmorphy associated with liver metastases of carcinoma, usually breast carcinoma. It may cause portal hypertension. The pathogenesis of this condition appears to be related to multifocal occlusion of intrahepatic branches of the portal vein by neoplasic thrombi and desmoplastic changes. The prognosis is poor despite apparent tumor regression on imaging. We report a case of variceal bleeding revealing a hepar lobatum carcinomatosum. Magnetic resonance imaging supported this diagnosis which was suspected in the clinical context.
authors.affiliation: Service d'Hépatologie et de Soins Intensifs Digestifs, Hôpital Universitaire Jean-minjoz, Besançon cedex, France. jpcervoni@chu-besancon.fr
authors.forename: J-P
authors.initials: JP
authors.lastname: Cervoni
authors.forename: A
authors.initials: A
authors.lastname: Dobrin
authors.forename: N
authors.initials: N
authors.lastname: Sailley
authors.forename: L
authors.initials: L
authors.lastname: Chaigneau
authors.forename: T
authors.initials: T
authors.lastname: Thevenot
authors.forename: C
authors.initials: C
authors.lastname: Richou
authors.forename: C
authors.initials: C
authors.lastname: Vanlemmens
authors.forename: V
authors.initials: V
authors.lastname: Di Martino
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000150:complications* / Q000556:secondary*; D005260:Female; D006801:Humans; D006975:Hypertension, Portal / Q000209:etiology*; D008113:Liver Neoplasms / Q000150:complications* / Q000556:secondary*; D008875:Middle Aged