title: [A recurrent case of lipid-secreting carcinoma of the breast successfully treated with capecitabine].
abstract: We herein report a recurrent case of lipid-secreting carcinoma of the breast which was successfully treated with capecitabine. A 50-year-old female underwent a pectoralis-preserving mastectomy for left breast cancer in December 2002. The clinical staging of the disease was T2N1M0 (stage II B) and ER (-), PgR(-), HER2 (1+). Microscopic examinations revealed solid alveolar proliferation in the majority of the tumor cells, which had an abundant foamy cytoplasm. A variable amount of neutral lipid was also identified in the cytoplasm of the tumor cells by Sudan III staining. After the operation, the patient received two courses of systemic chemotherapy using docetaxel (60 mg/m(2)). In March 2004, she was diagnosed to have a recurrence in the thoracic wall. She received radiotherapy (total 50 Gy radiation), but it proved to be ineffective. In June 2004, treatment using capecitabine (2,400 mg/day) was therefore attempted. Two courses of the treatment resulted in a complete response of the tumor. The above patient has since continued to show a complete response with capecitabine for over 3.5 years.
authors.affiliation: Dept. of Surgery, Yamaguchi Grand Medical Center.
authors.forename: Ryuichiro
authors.initials: R
authors.lastname: Suto
authors.forename: Syungo
authors.initials: S
authors.lastname: Miyamoto
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Kaneda
authors.forename: Nobuya
authors.initials: N
authors.lastname: Zenpo
authors.forename: Satoru
authors.initials: S
authors.lastname: Kurata
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Nakayasu
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Kamei
mesh_terms: D001706:Biopsy; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D000069287:Capecitabine; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D005472:Fluorouracil / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D050356:Lipid Metabolism; D008327:Mammography; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000601:surgery
chemical_list: D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil