Whole structure-activity relationships of the fat-accumulation inhibitor (-)-ternatin: recognition of the importance of each amino acid residue.
A series of Ala and Aoc analogues of (-)-ternatin were prepared, and their bioactivities were assessed by a fat-accumulation inhibition assay using 3T3-L1 adipocytes, which led to the discovery of key structure-activity relationships (SAR).
Shimokawa
Kenichiro
K
Department of Chemistry, Graduate School of Science, Nagoya University, Furo-cho, Chikusa, Nagoya 464-8602, Japan.
Iwase
Yoshiaki
Y
Miwa
Ryoka
R
Yamada
Kaoru
K
Uemura
Daisuke
D
D041721:3T3-L1 Cells; D017667:Adipocytes / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D000596:Amino Acids / Q000737:chemistry*; D000818:Animals; D005223:Fats / Q000037:antagonists & inhibitors* / Q000378:metabolism; D051379:Mice; D008968:Molecular Conformation; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000596:Amino Acids; D005223:Fats; D010456:Peptides, Cyclic; C085773:ternatin heptapeptide