Effect of acid suppression on gastric myoelectrical activity in GERD.
OBJECTIVE
The study aimed to investigate whether acid suppression influences gastric myoelectrical activity in patients with reflux disease.


METHODS
Twenty-eight patients with erosive esophagitis underwent electrogastrography. All patients were studied before and after esomeprazole. Subjects were divided into mild or moderate esophagitis in order to determine any variation in response related to esophagitis severity.


RESULTS
The reflux symptom improved from 4.2 at baseline to 1.0 at week 8 (P < 0.001). A significant increase in postprandial gastric 3 cycle per minute (normal) activity was observed at week 8 (P < 0.05). There was also significantly increased postprandial gastric 3 cycle per minute (normal) activity in moderate esophagitis (P < 0.05).


CONCLUSIONS
The effect of acid suppression on gastric myoelectrical activity is subtle with an enhancement in normal gastric myoelectrical activity. The myoelectrical response to acid suppression appears to be associated with esophagitis severity.
Chen
Chien-Lin
CL
Department of Medicine, Buddhist Tzu Chi General Hospital and University School of Medicine, Hualien 970, Taiwan. harry.clchen@msa.hinet.net
Yi
Chih-Hsun
CH
Kuo
Terry B J
TB
Yang
Cheryl C H
CC
D000328:Adult; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000494:pharmacology*; D004334:Drug Administration Schedule; D064098:Esomeprazole / Q000008:administration & dosage / Q000494:pharmacology*; D004942:Esophagitis, Peptic / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016065:Myoelectric Complex, Migrating / Q000187:drug effects*; D019518:Postprandial Period; D012720:Severity of Illness Index; D016896:Treatment Outcome; D055815:Young Adult
D000897:Anti-Ulcer Agents; D064098:Esomeprazole