Estimating the impact of vaccination on acute simian-human immunodeficiency virus/simian immunodeficiency virus infections.
The dynamics of HIV infection have been studied in humans and in a variety of animal models. The standard model of infection has been used to estimate the basic reproductive ratio of the virus, calculated from the growth rate of virus in acute infection. This method has not been useful in studying the effects of vaccination, since, for the vaccines developed so far, early growth rates of virus do not differ between control and vaccinated animals. Here, we use the standard model of viral dynamics to derive the reproductive ratio from the peak viral load and nadir of target cell numbers in acute infection. We apply this method to data from studies of vaccination in SHIV and SIV infection and demonstrate that vaccination can reduce the reproductive ratio by 2.3- and 2-fold, respectively. This method allows the comparison of vaccination efficacies among different viral strains and animal models in vivo.
Petravic
Janka
J
Complex Systems in Biology Group, Centre for Vascular Research, University of New South Wales 2052, New South Wales, Australia.
Ribeiro
Ruy M
RM
Casimiro
Danilo R
DR
Mattapallil
Joseph J
JJ
Roederer
Mario
M
Shiver
John W
JW
Davenport
Miles P
MP
D000208:Acute Disease; D000818:Animals; D018791:CD4 Lymphocyte Count; D006678:HIV / Q000276:immunology*; D008253:Macaca mulatta; D019713:Receptors, CCR5 / Q000502:physiology; D018449:SAIDS Vaccines / Q000276:immunology*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000276:immunology; D014611:Vaccination / Q000662:veterinary*; D019562:Viral Load
D019713:Receptors, CCR5; D018449:SAIDS Vaccines
Lancet. 1999 Nov 20;354(9192):1782-5
10577640
Nature. 2002 Jan 17;415(6869):331-5
11797011
J Exp Med. 2006 Jun 12;203(6):1533-41
16735692
J Virol. 2004 Sep;78(18):10096-103
15331742
Nature. 2005 Apr 28;434(7037):1093-7
15793563
Nature. 1995 Jan 12;373(6510):117-22
7529365
J Virol. 2005 Aug;79(15):10059-62
16014966
J Virol. 2003 Nov;77(21):11708-17
14557656
J Acquir Immune Defic Syndr. 2006 Mar;41(3):259-65
16540926
J Virol. 2006 Oct;80(19):9861-4
16973590
J Virol. 2005 Jul;79(14):9228-35
15994817
J Virol. 1999 Jun;73(6):4829-39
10233944
Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7247-51
8692977
Nature. 1995 Jan 12;373(6510):123-6
7816094
Cell. 2002 Jul 26;110(2):135-8
12150921
J Infect Dis. 2001 Feb 15;183(4):555-62
11170980
J Theor Biol. 2000 Apr 7;203(3):285-301
10716909
J Virol. 2007 Aug;81(15):8025-9
17507462
J Virol. 1997 Oct;71(10):7518-25
9311831
Nat Med. 2002 Mar;8(3):207-10
11875482
PLoS Med. 2006 Dec;3(12):e484
17147468
Science. 1996 Mar 15;271(5255):1582-6
8599114
J Exp Med. 1999 Sep 20;190(6):841-50
10499922
Immunol Rev. 2007 Apr;216:164-75
17367342
Nature. 2007 Sep 27;449(7161):390
17898737
AIDS. 1999 Jun 18;13(9):1015-9
10397529
Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):19079-84
18025463
Proc Biol Sci. 2001 Apr 22;268(1469):847-54
11345331
J Exp Med. 1999 May 17;189(10):1545-54
10330433
J Virol. 2003 Apr;77(8):5037-8
12663814