[Estimating genetic distance and phylogenetic tree of HPA-1-3, 5, and 15 in different populations].
According to the human platelet alloantigens (HPA) polymorphisms in five systems, the distributions of HPA-1 -3, 5, and 15 systems in 1 000 Chinese donors were carried out by using a polymerase chain reaction with sequence-specific primers (PCR-SSP) method. The genetic distance and phylogenetic tree between Chinese Hans and other populations were estimated by using DISPAN and PHYLIP software. As presented by the phylogenetic tree, Asian had a convergence with European first, and grouped together with African. Beninese which came from Africa was on the top of dendrogram. Indian was located between Asian and European. Brazilian was converged with other Europe populations. Oceanian Polynexiya had been shown specifically to cluster with Asia populations. These results proved the "out of Africa theory" from one side, and it also confirmed that early migration of Asian is from south to southeast, and east Asia., thus it is probable that Europeans are migrated from south to north, and west Europe. As genetic distance was estimated effectively by HPA systems, HPA systems could serve as the genetic marker in human migration and evolution research.
Feng
Ming-Liang
ML
Shanghai Blood Center, Shanghai 200051, China. fengml@sh163.net
Huang
Hui
H
Shen
Tong
T
Zhang
Xi
X
Yin
Biao
B
Yang
Jian-Hao
JH
Liu
Da-Zhuang
DZ
D015703:Antigens, CD / Q000235:genetics; D016824:Antigens, Human Platelet / Q000235:genetics*; D044466:Asian People; D044383:Black People; D058851:GPI-Linked Proteins; D005787:Gene Frequency / Q000235:genetics; D006801:Humans; D039661:Integrin beta3; D009363:Neoplasm Proteins / Q000235:genetics; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D044469:Racial Groups; D044465:White People
C115212:2a alloantigen, human; C071221:2b alloantigen, human; C044561:3a alloantigen, human; C083448:3b alloantigen, human; C071092:5a alloantigen, human; C055973:5b alloantigen, human; D015703:Antigens, CD; D016824:Antigens, Human Platelet; C120523:CD109 protein, human; D058851:GPI-Linked Proteins; C061248:ITGB3 protein, human; D039661:Integrin beta3; D009363:Neoplasm Proteins; C083451:human platelet antigen 1b