Levels of angiogenic factors in pregnancy and post-partum bleeding.
We have studied if serum levels of soluble fms-like tyrosine kinase-1 (sFlt-1) and placenta growth factor (PlGF) in pregnancy could predict excess post-partum bleeding. In 392 normotensive singleton pregnancies, concentrations of sFlt-1 and PlGF in the first, second, and third trimester were compared between women with and without excess post-partum bleeding, defined as blood loss volume of at least 500 mL. Mean concentrations of sFlt-1 were consistently higher in all three trimesters among women who had excess post-partum bleeding compared to women without this, but significantly higher only in the second trimester. For PlGF, there were no significant differences between the groups. High concentrations of the anti-angiogenic factor sFlt-1 in maternal circulation during pregnancy may be associated with an increased risk of excess post-partum bleeding.
Eskild
Anne
A
Department of Obstetrics and Gynecology, Akershus University Hospital and the Faculty of Medicine, University of Oslo, Norway. anne.eskild@medisin.uio.no
Jeansson
Stig
S
Jenum
Pål A
PA
Staff
Anne C
AC
Thadhani
Ravi
R
Karumanchi
Ananth
A
Vatten
Lars J
LJ
D016022:Case-Control Studies; D005260:Female; D006801:Humans; D000072483:Placenta Growth Factor; D006473:Postpartum Hemorrhage / Q000097:blood*; D011247:Pregnancy / Q000097:blood*; D011257:Pregnancy Proteins / Q000097:blood*; D018709:Statistics, Nonparametric; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood*
C000608036:PGF protein, human; D011257:Pregnancy Proteins; D000072483:Placenta Growth Factor; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1