title: Changes in platelet function in Dachshunds with early stages of myxomatous mitral valve disease.
abstract: The aim of this study was to evaluate platelet function in Dachshunds during early stages of myxomatous mitral valve disease. Clinical examination and echocardiography were performed in 34 wirehaired standard sized Dachshunds. Platelet function was evaluated using the PFA-100 (reported as closure time). In addition, whole blood platelet aggregation response and hemostatic markers were evaluated. Significant longer PFA-100 closure time (CT) was found in 12 Dachshunds with mild mitral regurgitation (MR) compared to 22 Dachshunds with minimal MR. Only five Dachshunds responded to adenosine diphosphate in the whole blood aggregation analyses. There were no differences between the two dog groups in plasma fibrinogen, plasma von Willebrand factor (vWf) or vWf multimer distribution; however, there was a significant correlation between CT and plasma vWf concentration and CT and plasma fibrinogen concentration. The higher CT found in Dachshunds with mild MR suggests a form of platelet dysfunction in Dachshunds with MR.
authors.affiliation: Department of Basic Animal and Veterinary Sciences, University of Copenhagen, 7 Groennegaardsvej, Frederiksberg C DK-1870, Denmark. som@life.ku.dk
authors.forename: S G
authors.initials: SG
authors.lastname: Moesgaard
authors.forename: T M
authors.initials: TM
authors.lastname: Sørensen
authors.forename: A
authors.initials: A
authors.lastname: Sterup
authors.forename: I
authors.initials: I
authors.lastname: Tarnow
authors.forename: A T
authors.initials: AT
authors.lastname: Kristensen
authors.forename: A L
authors.initials: AL
authors.lastname: Jensen
authors.forename: L H
authors.initials: LH
authors.lastname: Olsen
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000378:metabolism / Q000473:pathology*; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D016014:Linear Models; D008297:Male; D008944:Mitral Valve Insufficiency / Q000097:blood / Q000662:veterinary*; D010974:Platelet Aggregation / Q000502:physiology; D010979:Platelet Function Tests / Q000662:veterinary; D014841:von Willebrand Factor / Q000378:metabolism
chemical_list: D014841:von Willebrand Factor; D005340:Fibrinogen