title: CHECK (Cohort Hip and Cohort Knee): similarities and differences with the Osteoarthritis Initiative.
abstract: OBJECTIVE
  To describe the osteoarthritis study population of CHECK (Cohort Hip and Cohort Knee) in comparison with relevant selections of the study population of the Osteoarthritis Initiative (OAI) based on clinical status and radiographic parameters.
  
  
  METHODS
  In The Netherlands a prospective 10-year follow-up study was initiated by the Dutch Arthritis Association on participants with early osteoarthritis-related complaints of hip and/or knee: CHECK. In parallel in the USA an observational 4-year follow-up study, the OAI, was started by the National Institutes of Health, on patients with or at risk of symptomatic knee osteoarthritis. For comparison with CHECK, the entire cohort and a subgroup of individuals excluding those with exclusively hip pain were compared with relevant subpopulations of the OAI.
  
  
  RESULTS
  At baseline, CHECK included 1002 participants with in general similar characteristics as described for the OAI. However, significantly fewer individuals in CHECK had radiographic knee osteoarthritis at baseline when compared with the OAI (p<0.001). In contrast, at baseline, the CHECK cohort reported higher scores on pain, stiffness and functional disability (Western Ontario and McMaster osteoarthritis index) when compared with the OAI (all p<0.001). These differences were supported by physical health status in contrast to mental health (Short Form 36/12) was at baseline significantly worse for the CHECK participants (p<0.001).
  
  
  CONCLUSIONS
  Although both cohorts focus on the early phase of osteoarthritis, they differ significantly with respect to structural (radiographic) and clinical (health status) characteristics, CHECK expectedly representing participants in an even earlier phase of disease.
authors.affiliation: University Medical Center Utrecht, Department of Rheumatology and Clinical Immunology (F02.127), PO Box 85500, 3508 GA Utrecht, The Netherlands. j.wesseling@umcutrecht.nl
authors.forename: J
authors.initials: J
authors.lastname: Wesseling
authors.forename: J
authors.initials: J
authors.lastname: Dekker
authors.forename: W B
authors.initials: WB
authors.lastname: van den Berg
authors.forename: S M A
authors.initials: SM
authors.lastname: Bierma-Zeinstra
authors.forename: M
authors.initials: M
authors.lastname: Boers
authors.forename: H A
authors.initials: HA
authors.lastname: Cats
authors.forename: P
authors.initials: P
authors.lastname: Deckers
authors.forename: K J
authors.initials: KJ
authors.lastname: Gorter
authors.forename: P H T G
authors.initials: PH
authors.lastname: Heuts
authors.forename: W K H A
authors.initials: WK
authors.lastname: Hilberdink
authors.forename: M
authors.initials: M
authors.lastname: Kloppenburg
authors.forename: R G H H
authors.initials: RG
authors.lastname: Nelissen
authors.forename: F G J
authors.initials: FG
authors.lastname: Oosterveld
authors.forename: J C M
authors.initials: JC
authors.lastname: Oostveen
authors.forename: L D
authors.initials: LD
authors.lastname: Roorda
authors.forename: M A
authors.initials: MA
authors.lastname: Viergever
authors.forename: S
authors.initials: S
authors.lastname: ten Wolde
authors.forename: F P J G
authors.initials: FP
authors.lastname: Lafeber
authors.forename: J W J
authors.initials: JW
authors.lastname: Bijlsma
mesh_terms: D000368:Aged; D004185:Disability Evaluation; D018450:Disease Progression; D004812:Epidemiologic Methods; D005221:Fatigue / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D020370:Osteoarthritis, Knee / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D010146:Pain / Q000209:etiology; D011379:Prognosis; D016059:Range of Motion, Articular
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