Absence of human herpes virus-8 (HHV8) in nephrogenic systemic fibrosis.
BACKGROUND
Nephrogenic systemic fibrosis (NSF) is a fibrosing disorder that exhibits CD34 expression in the majority of lesional spindle cells. Several features of NSF bear similarity to Kaposi sarcoma.


RESULTS
Skin lesions procured from two male NSF patients were found to be negative for HHV8 (LNA-1) by means of immunohistochemistry.


CONCLUSIONS
This finding negates a role for HHV8 in the pathogenesis of NSF.
O'Donnell
Patrick J
PJ
Department of Pathology, Baystate Medical Center, Tufts University School of Medicine, Springfield, MA, USA. patrick.odonnell@bhs.org
Duke
Wayne H
WH
Pantanowitz
Liron
L
Nephrol Dial Transplant. 2006 Apr;21(4):1104-8
16431890
Am J Dermatopathol. 2001 Oct;23(5):383-93
11801769
Curr Opin Rheumatol. 2006 Nov;18(6):614-7
17053507
Kaohsiung J Med Sci. 2002 Aug;18(8):393-6
12476682
Virchows Arch A Pathol Anat Histopathol. 1987;412(2):161-8
3122416
Blood. 2006 Jul 1;108(1):141-51
16543476
J Invest Dermatol. 1999 Oct;113(4):613-6
10504449
Am J Dermatopathol. 2003 Aug;25(4):358
12876500
Am J Clin Pathol. 2004 Mar;121(3):335-42
15023037
Arch Dermatol. 1991 Apr;127(4):523-9
2006877
J Cutan Pathol. 2008 May;35(5):520-2
18399814
Urol J. 2004 Spring;1(2):111-4
17874397
Nephrol Dial Transplant. 1998 Sep;13(9):2373-6
9761528
Exp Dermatol. 2005 Jan;14(1):41-9
15660918
J Clin Pathol. 2005 Aug;58(8):856-9
16049289
Lancet. 2000 Sep 16;356(9234):1000-1
11041404
J Cutan Pathol. 2005 Aug;32(7):484-90
16008692
J Korean Med Sci. 2001 Feb;16(1):130-4
11289393
Am J Kidney Dis. 2006 Jan;47(1):167-70
16377398
J Am Coll Radiol. 2008 Jan;5(1):23-8
18180005
J Am Coll Radiol. 2008 Jan;5(1):36-9
18180007
Clin Exp Dermatol. 2004 Mar;29(2):188-91
14987280
Am J Clin Pathol. 2004 Mar;121(3):330-4
15023036