title: Regulation of Wilms' tumor gene expression by nerve growth factor and follicle-stimulating hormone in the immature mouse ovary.
abstract: This study investigated the regulation of Wilms' tumor gene (WT1) in the ovary by nerve growth factor and FSH to better understand signals that initiate early follicular growth. Nerve growth factor showed a direct stimulatory effect on endogenous expression of WT1, whereas FSH attenuated basal and nerve growth factor-stimulated WT1 protein expression, which most likely depended on FSH responsiveness according to the follicle growth stage.
authors.affiliation: Department of Obstetrics & Gynecology, Hanyang Medical University, Seoul, Korea. rohjaesook@hanyang.ac.kr
authors.forename: Jaesook
authors.initials: J
authors.lastname: Roh
authors.forename: Jeehyeon
authors.initials: J
authors.lastname: Bae
authors.forename: Kangseok
authors.initials: K
authors.lastname: Lee
authors.forename: Kelly
authors.initials: K
authors.lastname: Mayo
authors.forename: Lonnie
authors.initials: L
authors.lastname: Shea
authors.forename: Teresa K
authors.initials: TK
authors.lastname: Woodruff
mesh_terms: D000375:Aging / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002460:Cell Line; D002478:Cells, Cultured; D005260:Female; D005640:Follicle Stimulating Hormone / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects* / Q000502:physiology; D016162:Genes, Wilms Tumor / Q000502:physiology*; D006107:Granulosa Cells / Q000166:cytology / Q000502:physiology; D051379:Mice; D023421:Models, Animal; D020932:Nerve Growth Factor / Q000494:pharmacology*; D006080:Ovarian Follicle / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D010053:Ovary / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D025721:WT1 Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D025721:WT1 Proteins; D005640:Follicle Stimulating Hormone; D020932:Nerve Growth Factor
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