title: Challenges and opportunities for local and systemic delivery of siRNA and antisense oligonucleotides.
authors.affiliation: RNA Therapeutics, Merck Research Laboratories, West Point, Pennsylvania, USA. laura_sepplorenzino@merck.com
authors.forename: L
authors.initials: L
authors.lastname: Sepp-Lorenzino
authors.forename: Mk
authors.initials: M
authors.lastname: Ruddy
mesh_terms: D016503:Drug Delivery Systems; D015894:Genome, Human / Q000502:physiology*; D006801:Humans; D020319:Oligodeoxyribonucleotides, Antisense / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use*; D034741:RNA, Small Interfering / Q000008:administration & dosage / Q000627:therapeutic use*; D013678:Technology, Pharmaceutical / Q000379:methods / Q000639:trends*
chemical_list: D020319:Oligodeoxyribonucleotides, Antisense; D034741:RNA, Small Interfering