title: [Effects of Rhodiola rosea on body weight and intake of sucrose and water in depressive rats induced by chronic mild stress].
abstract: OBJECTIVE
  To explore the effects of Rhodiola rosea on the body weight and the intake of sucrose and water in depressive rats induced by chronic mild stress.dz
  
  
  METHODS
  A total of 70 male SD rats were divided into seven groups, including normal control group (treated with 0.5% sodium carboxymethycellulose), untreated group, negative control group (treated with 0.5% sodium carboxymethycellulose), positive control group (treated with fluoxetine), low-, medium- and high-dose Rhodiola rosea group (treated with 1.5, 3, 6 g/kg Rhodiola rosea respectively). Except for rats in normal control group, the other sixty rats endured chronic stress for 4 weeks to establish the depression model. After that, rats were administered Rhodiola rosea for 3 weeks. During the whole experiment, the body weight, and sucrose intake, tap water intake of all rats were examined once a week.
  
  
  RESULTS
  After the termination of the stress regime, compared with the normal control group, the body weight and 1% sucrose intake in depressive rats were decreased. After 3-week Rhodiola rosea treatment, the body weight and 1% sucrose intake increased in rats of the low-dose Rhodiola rosea group and recovered to the level of the normal control group.
  
  
  CONCLUSIONS
  Low-dose Rhodiola rosea can increase the body weight and sucrose intake of depressive rats, making them recover to normal status.
authors.affiliation: Division of Neuroscience, Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong Province 510080, China.
authors.forename: Qiao-Ge
authors.initials: QG
authors.lastname: Chen
authors.forename: Yuan-Shan
authors.initials: YS
authors.lastname: Zeng
authors.forename: Jiu-Yu
authors.initials: JY
authors.lastname: Tang
authors.forename: Ya-Jing
authors.initials: YJ
authors.lastname: Qin
authors.forename: Sui-Jun
authors.initials: SJ
authors.lastname: Chen
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Zhong
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D003863:Depression / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D004326:Drinking / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D008517:Phytotherapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D029771:Rhodiola / Q000737:chemistry*; D013315:Stress, Psychological / Q000188:drug therapy; D013395:Sucrose / Q000008:administration & dosage
chemical_list: D004365:Drugs, Chinese Herbal; D013395:Sucrose