New platinum(II) complexes targeting the loops of the human telomeric G-quadruplex.
Two novel series of platinum(II) complexes have been designed and shown to interact with the human telomeric G-quadruplex-DNA via different binding modes: i- terpyridine-platinum (Pt-tpy) complexes covalently interact with quadruplex-DNA via selective platination of adenine residues of the loops, their interaction being driven by the aromatic surface of the ligand; ii- platinum-quinacridine hybrid (Pt-MPQ) interacts with quadruplex-DNA via a dual noncovalent/covalent binding mode, targeting preferentially guanines constitutive of external G-quartets. Therefore, platinum complexes presented herein constitute potential agents for irreversible trapping of G-quadruplex.DNA.
Bertrand
Hélène
H
Institut Curie - CNRS UMR 176, Centre Universitaire, Bât. 110, 91405 Orsay, France.
Bombard
Sophie
S
Monchaud
David
D
Teulade-Fichou
Marie-Paule
MP
D000166:Acridines / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D054856:G-Quadruplexes; D006801:Humans; D008958:Models, Molecular; D009944:Organoplatinum Compounds / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D016615:Telomere / Q000737:chemistry*
D000166:Acridines; D009944:Organoplatinum Compounds; D011725:Pyridines; D004247:DNA