Fluorescent agonists and antagonists for vasopressin/oxytocin G protein-coupled receptors: usefulness in ligand screening assays and receptor studies.
Different series of fluorescent agonists and antagonists have been developed and characterized for arginine-vasopressin and oxytocin G protein-coupled receptors. Both cyclic and linear peptide analogs of the neurohypophysial hormones are useful tools for investigating receptor localization and trafficking, analysing receptor structural organization, and developing new receptor-selective high-throughput ligand screening assays.
Mouillac
B
B
CNRS, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France. Bernard.Mouillac@igf.cnrs.fr.
Manning
M
M
Durroux
T
T
D065092:Antidiuretic Hormone Receptor Antagonists; D000943:Antigens, Differentiation / Q000378:metabolism; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005456:Fluorescent Dyes / Q000494:pharmacology*; D043562:Receptors, G-Protein-Coupled / Q000819:agonists* / Q000037:antagonists & inhibitors* / Q000378:metabolism; D018045:Receptors, Oxytocin / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism; D017483:Receptors, Vasopressin / Q000819:agonists / Q000378:metabolism
D065092:Antidiuretic Hormone Receptor Antagonists; D000943:Antigens, Differentiation; D005456:Fluorescent Dyes; D043562:Receptors, G-Protein-Coupled; D018045:Receptors, Oxytocin; D017483:Receptors, Vasopressin
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