Obesity and type 2 diabetes are associated with an increased risk of developing cancer and a worse prognosis; epidemiological and mechanistic evidence.
Both obesity and Type 2 diabetes are independently associated with an increased risk of developing cancer and an increased mortality. The etiology is yet to be determined but insulin resistance and hyperinsulinemia maybe important factors. Hyperglycemia, hyperlipidemia and inflammatory cytokines in addition to the insulin-like growth factors are also possible factors involved in the process.
LeRoith
D
D
Division of Endocrinology and Diabetes, Department of Medicine, Mount Sinai School of Medicine, New York, USA. derek.leroith@mssm.edu
Novosyadlyy
R
R
Gallagher
E J
EJ
Lann
D
D
Vijayakumar
A
A
Yakar
S
S
D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000453:epidemiology / Q000235:genetics; D004195:Disease Models, Animal; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000175:diagnosis* / Q000453:epidemiology* / Q000209:etiology* / Q000235:genetics; D009765:Obesity / Q000150:complications* / Q000453:epidemiology / Q000235:genetics; D011379:Prognosis; D012307:Risk Factors; D015398:Signal Transduction / Q000235:genetics* / Q000502:physiology