title: A technological update of molecular diagnostics for infectious diseases.
abstract: Identification of a causative pathogen is essential for the choice of treatment for most infectious diseases. Many FDA approved molecular assays; usually more sensitive and specific compared to traditional tests, have been developed in the last decade. A new trend of high throughput and multiplexing assays are emerging thanks to technological developments for the human genome sequencing project. The applications of microarray and ultra high throughput sequencing technologies for diagnostic microbiology are reviewed. The race for the $1000 genome technology by 2014 will have a profound impact in diagnosis and treatment of infectious diseases in the near future.
authors.affiliation: Moores Cancer Center, University of California, San Diego, 3855 Health Sciences Drive, 0815, La Jolla, CA 92093, USA. ytliu@ucsd.edu
authors.forename: Yu-Tsueng
authors.initials: YT
authors.lastname: Liu
mesh_terms: D003141:Communicable Diseases / Q000175:diagnosis* / Q000382:microbiology / Q000821:virology; D004269:DNA, Bacterial / Q000032:analysis*; D004279:DNA, Viral / Q000032:analysis*; D020869:Gene Expression Profiling / Q000379:methods; D006801:Humans; D008828:Microbiological Techniques; D025202:Molecular Diagnostic Techniques; D020411:Oligonucleotide Array Sequence Analysis; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D017422:Sequence Analysis, DNA
chemical_list: D004269:DNA, Bacterial; D004279:DNA, Viral
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