title: Re-identification of clinical isolates of the Pseudallescheria boydii-complex involved in near-drowning.
abstract: Fungal infections caused by the members of the genera Pseudallescheria and/or Scedosporium are important complications in patients after near-drowning. As the taxonomy of Pseudallescheria and Scedosporium has been revised, clinical isolates from 11 patients, after near-drowning, previously identified as P. boydii or S. apiospermum had to be re-identified. S. apiospermum, now separated from P. boydii as a distinct species, was found most frequently (n = 8), while S. aurantiacum, recently described as new species and P. boydii were less common (n = 2 and n = 1, respectively). Three patients near-drowned during the Tsunami 2004 were infected by different species of the P. boydii complex. In vitro testing resulted in lowest minimal inhibitory concentration (MICs) for voriconazole (range 0.25-2.0 microg ml(-1)).
authors.affiliation: Laboratory for Pseudallescheria boydii/Scedosporium spp., Division of Mycology, Robert Koch-Institute, Berlin, Germany. tintelnotk@rki.de
authors.forename: Kathrin
authors.initials: K
authors.lastname: Tintelnot
authors.forename: N
authors.initials: N
authors.lastname: Wagner
authors.forename: Michael
authors.initials: M
authors.lastname: Seibold
authors.forename: G S
authors.initials: GS
authors.lastname: de Hoog
authors.forename: Regine
authors.initials: R
authors.lastname: Horré
mesh_terms: D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000494:pharmacology; D001921:Brain / Q000382:microbiology; D002675:Child, Preschool; D004271:DNA, Fungal / Q000032:analysis; D021903:DNA, Ribosomal Spacer / Q000032:analysis; D005260:Female; D006801:Humans; D007223:Infant; D008168:Lung / Q000382:microbiology; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D008271:Mycetoma / Q000382:microbiology*; D016533:Mycological Typing Techniques; D015701:Near Drowning / Q000150:complications*; D011541:Pseudallescheria / Q000145:classification* / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D021681:Scedosporium / Q000145:classification* / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D012867:Skin / Q000382:microbiology; D013045:Species Specificity
chemical_list: D000935:Antifungal Agents; D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer