title: [Cryptococcal meningitis as a diagnostic problem in a patient with SLE--case report].
abstract: Systemic erythematosus lupus (SLE) is a disease with wide range of clinical manifestations, signs and symptoms. Disease outcome depends mostly on the affection of kidneys and central nervous system by the disease. Very important cause of death in patients with SLE is infection. Infections are very common among these patients due to aggressive immunosuppressive treatment that is needed for the disease inflammatory activity control. In this case report we have presented a patient with SLE who initially had severe renal affection, but also complications of immunosuppressive therapy that was administered. Even though the disease was accidentally diagnosed, it had a severe clinical progress. Because of lupus nephropathy, in the early phase of the disease we administered aggressive immunosuppressive therapy (combined parenteral therapy of glucocorticoides and cyclophosphamide). As an outcome of the combined effect of disease and immunosuppressive agents used in the treatment of the disease, the patient had increased infective diathesis (repeated infections caused by S. enteritidis--urinary infections and sepsis). During one of the disease flares the patient was hospitalized an opportunistic infection developed. It was meningitis caused by C. neoformans. This opportunistic mycosis infection presented with clinically totally nonspecific signs and symptoms of CNS affection. Therefore, we suspected affection of CNS with SLE. Even though all diagnostic procedures were made on time and that adequate antifungal and supportive agents were applied very early after the infection onset, the outcome was fatal. Because of infective diathesis in patients with SLE, which present with common and opportunistic infections, and due to high mortality rates caused by these infections, we have tried to emphasise the importance of taking adequate specimens early after infection outcome for these rare infective agents like C. neophormans. In recent medical literature are dominant cases reported in Asia. Reports from Europe are very rare, and this case is the one of that kind in Croatia.
authors.affiliation: Zavod za klinicku immunologiju i reumatologiju, Klinika za unutarnje bolesti Medicinskog fakulteta, KBC Zagreb.
authors.forename: Dubravka
authors.initials: D
authors.lastname: Bosnić
authors.forename: Mislav
authors.initials: M
authors.lastname: Cerovec
authors.forename: Branimir
authors.initials: B
authors.lastname: Anić
authors.forename: Miroslav
authors.initials: M
authors.lastname: Mayer
authors.forename: Mirna
authors.initials: M
authors.lastname: Sentić
authors.forename: Marko
authors.initials: M
authors.lastname: Baresić
authors.forename: Jasenka
authors.initials: J
authors.lastname: Markeljević
authors.forename: Nada
authors.initials: N
authors.lastname: Cikes
mesh_terms: D000328:Adult; D006801:Humans; D016867:Immunocompromised Host; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008297:Male; D016919:Meningitis, Cryptococcal / Q000150:complications / Q000175:diagnosis*; D009894:Opportunistic Infections / Q000175:diagnosis*