Labeling of Polymer Nanostructures for Medical Imaging: Importance of crosslinking extent, spacer length, and charge density.
Radiolabeling studies were employed to investigate the influence of structure on the efficiency of surface functionalization for poly(acrylic acid)-coated shell crosslinked nanoparticles (SCKs) with two types of amine-terminated DOTA chelators. An intricate interplay between the chemical and physical properties of both the DOTA derivative and the SCK nanostructures was revealed, demonstrating the importance of structural control.
Xu
Jinqi
J
Center of Materials Innovation and Department of Chemistry, Washington University in Saint Louis, Saint Louis, MO 63130.
Sun
Guorong
G
Rossin
Raffaella
R
Hagooly
Aviv
A
Li
Zicheng
Z
Fukukawa
Ken-Ichi
KI
Messmore
Benjamin W
BW
Moore
Dennis A
DA
Welch
Michael J
MJ
Hawker
Craig J
CJ
Wooley
Karen L
KL
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