Type 2 diabetes mellitus: a high-risk condition for cardiovascular disease irrespective of the different degrees of obesity.
BACKGROUND
Measurement of body weight with body mass index (BMI) is often utilized to stratify cardiovascular disease (CVD) risk.


OBJECTIVE
To determine CVD risk profile and disease burden in subjects with type 2 diabetes mellitus (T2DM) across different categories of body weight as defined by BMI.


METHODS
Prospective observational study.


METHODS
CVD risk including metabolic syndrome (MetS) and prevalence of macrovascular complications were determined for each category of body weight as defined by the World Health Organisation (WHO) classification.


RESULTS
A total of 390 subjects were included in this study of which 35.9% were non-obese (BMI <30 kg/m(2)). Although increasing obesity as defined by BMI was associated with higher prevalence of central abdominal obesity, hypertension and MetS (P < 0.05), dyslipidaemia and macrovascular complications were not significantly different across the various body weight categories (P = NS). Similar observation was seen in non-obese (BMI <30 kg/m(2)) and obese subjects (BMI >30 kg/m(2)). Among non-obese (including normal weight) cohort, the majority of these subjects had adverse CVD risk profile including presence of at least two co-existing risk factors.


CONCLUSIONS
Subjects with T2DM possess adverse CVD risk factors with significant burden of macrovascular disease irrespective of their baseline body weight.
Song
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SH
Diabetes Centre, Northern General Hospital, Sheffield, UK. soon_song@hotmail.com
Hardisty
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CA
D000328:Adult; D000368:Aged; D015992:Body Mass Index; D001835:Body Weight; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000453:epidemiology; D003925:Diabetic Angiopathies / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D024821:Metabolic Syndrome / Q000150:complications*; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000453:epidemiology / Q000378:metabolism; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D055815:Young Adult