title: Carbamazepine-induced drug-induced hypersensitivity syndrome in a 14-year-old Japanese boy.
abstract: Drug-induced hypersensitivity syndrome (DIHS) is a life-threatening idiosyncratic drug reaction, and an early accurate diagnosis is essential for its treatment. We describe a 14-year-old boy with localization-related epilepsy, who developed severe adverse cutaneous and systemic reactions after 3 weeks of carbamazepine administration. During the course of the clinical symptoms, reactivation of human herpesvirus 6 (HHV-6) was proven by detection of the HHV-6 genome in serum and elevation of HHV-6 immunoglobulin G (IgG). He fulfilled the newly established criteria for DIHS. Among eight identified medications that can precipitate DIHS, four are antiepileptic drugs. Establishing a treatment strategy for DIHS is warranted to improve its outcome. Therefore, it is important to raise awareness of DIHS among epileptologists.
authors.affiliation: Department of Pediatrics, Ehime University Graduate School of Medicine, Toon, Ehime, Japan. yusuzuki@m.ehime-u.ac.jp
authors.forename: Yuka
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Mitsumasa
authors.initials: M
authors.lastname: Fukuda
authors.forename: Mikiko
authors.initials: M
authors.lastname: Tohyama
authors.forename: Manami
authors.initials: M
authors.lastname: Ishikawa
authors.forename: Masaki
authors.initials: M
authors.lastname: Yasukawa
authors.forename: Eiichi
authors.initials: E
authors.lastname: Ishii
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000009:adverse effects*; D002220:Carbamazepine / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology*; D004827:Epilepsy / Q000188:drug therapy; D004890:Erythema / Q000139:chemically induced; D015654:Herpesvirus 6, Human / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D008297:Male; D019349:Roseolovirus Infections / Q000150:complications
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine