Design, synthesis, structure-activity relationship and antibacterial activity series of novel imidazo fused quinolone carboxamides.
A series of novel 7,8 and 1,8 imidazo fused quinolone carboxamides are synthesized and evaluated against antibacterial activity. 1,8 Imidazo fused quinolones exhibit moderate antibacterial activity. Molecular modeling studies were carried out to optimize the pharmacophore.
Reddy
G Venkat
GV
Fluoroorganic Division, Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad, Andhrapradesh 500007, India.
Kanth
S Ravi
SR
Maitraie
D
D
Narsaiah
B
B
Rao
P Shanthan
PS
Kishore
K Hara
KH
Murthy
U S N
US
Ravi
B
B
Kumar
B Ashok
BA
Parthasarathy
T
T
D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D015195:Drug Design; D008826:Microbial Sensitivity Tests; D015363:Quinolones / Q000737:chemistry*; D013329:Structure-Activity Relationship
D000577:Amides; D000900:Anti-Bacterial Agents; D015363:Quinolones