Progression of atherosclerosis in hemodialysis patients: effect of adiponectin on carotid intima media thickness.
OBJECTIVE
We investigated the parameters related to the progression of common carotid artery intima media thickness (IMT) in hemodialysis (HD) patients.


METHODS
IMT was examined in 85 patients by ultrasonography at baseline and after 12 months. The difference in IMT between these two time points was calculated (DeltaIMT). We defined DeltaIMT< or =0.00 as 'progression', and DeltaIMT0.00 as 'stable'. Body fat distribution was calculated on computed tomography. Total adiponectin (T-Ad) and high molecular weight adiponectin (H-Ad) were measured by ELISA.


RESULTS
There were no significant differences between the two groups in all profiles except for the ratio of H-Ad to T-Ad (HMWR) at baseline. In the 'progression' group, IMT increased from 1.56+/-0.89 to 1.77+/-0.94 mm (p<0.001) and visceral fat area (60.3+/-30.7 to 69.2+/-37.5, cm2; p<0.01) increased. In the 'stable' group, HMWR increased from 31.3+/-5.4 to 37.6+/-7.3% (p<0.001). Multiple logistic regression analysis selected DeltaHMWR (p=0.031, odds ratio=0.928) independently of IMT progression. The correlation coefficient was -0.254 (p=0.019) between DeltaIMT and DeltaHMWR.


CONCLUSIONS
We found that an increase in HMWR was related to the stable state of IMT in HD patients.
Tsushima
Megumi
M
Oyokyo Kidney Research Institute, Hirosaki, Japan. staff@oyokyo.jp
Terayama
Yuriko
Y
Momose
Akishi
A
Funyu
Tomihisa
T
Ohyama
Chikara
C
D052242:Adiponectin / Q000502:physiology*; D000368:Aged; D050197:Atherosclerosis / Q000378:metabolism / Q000473:pathology*; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D017539:Tunica Intima / Q000000981:diagnostic imaging / Q000473:pathology*; D014463:Ultrasonography
D052242:Adiponectin