The ototoxic effect of boric acid solutions applied into the middle ear of guinea pigs.
This study analyzed the ototoxic effects of boric acid solutions. Boric acid solutions have been used as otologic preparations for many years. Boric acid is commonly found in solutions prepared with alcohol or distilled water but can also be found in a powder form. These preparations are used for both their antiseptic and acidic qualities in external and middle ear infections. We investigated the ototoxic effect of boric acid solutions on guinea pigs. We are unaware of any similar, previously published study of this subject in English. The study was conducted on 28 young albino guinea pigs. Prior to application of the boric acid solution under general anesthesia, an Auditory Brainstem Response (ABRs) test was applied to the right ear of the guinea pigs. Following the test, a perforation was created on the tympanic membrane of the right ear of each guinea pig and small gelfoam pieces were inserted into the perforated area. Test solutions were administered to the middle ear for 10 days by means of a transcanal route. Fifteen days after inserting the gelfoams in all of the guinea pigs, we anasthesized the guinea pigs and removed the gelfoams from the perforated region of the ear and then performed an ABRs on each guinea pig. The ABRs were within the normal range before the applications. After the application, no significant changes were detected in the ABRs thresholds in neither the saline group nor the group administered boric acid and distilled water solution; however, significant changes were detected in the ABRs thresholds of the Gentamicine and boric acid and alcohol solution groups. We believe that a 4% boric acid solution prepared with distilled water can be a more reliable preparation than a 4% boric acid solution prepared with alcohol.
Oztürkcan
Sedat
S
Department of Otorhinolaryngology and Head and Neck Surgery, Atatürk Research and Training Hospital, Ministry of Health, Izmir, Turkey.
Dündar
Riza
R
Katilmis
Hüseyin
H
Ilknur
Ali Ekber
AE
Aktaş
Sinem
S
Haciömeroğlu
Senem
S
D000818:Animals; D001309:Auditory Threshold; D001888:Boric Acids / Q000008:administration & dosage / Q000009:adverse effects*; D004427:Ear Diseases / Q000139:chemically induced* / Q000175:diagnosis; D004432:Ear, Middle / Q000187:drug effects*; D016057:Evoked Potentials, Auditory, Brain Stem; D006168:Guinea Pigs; D007306:Insecticides / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D012996:Solutions
D001888:Boric Acids; D007306:Insecticides; D012996:Solutions; C032688:boric acid
Am J Otol. 1993 Mar;14(2):141-6
8503487
Otol Neurotol. 2007 Aug;28(5):605-8
17450104
Pediatr Infect Dis J. 2001 Jan;20(1):104-7; discussion 120-2
11176587
J Laryngol Otol. 2003 Jan;117(1):39-42
12590854
Arch Otolaryngol Head Neck Surg. 1990 Apr;116(4):406-10
2317321
East Afr Med J. 2006 Jun;83(6):322-5
16989377
Med J Aust. 1975 Oct 18;2(16):634-8
1207541
J Laryngol Otol. 1998 Oct;112(10):925-8
10211213
Acta Otolaryngol Suppl. 1992;493:43-55
1636422
HNO. 1989 Sep;37(9):386-8
2808014
Laryngoscope. 1976 Aug;86(8):1177-87
181649