title: Management of evaporative dry eye in ectrodactyly-ectodermal dysplasia-clefting syndrome.
abstract: OBJECTIVE
  The purpose of this study is to report the features of dry eye and ocular surface disease in an unusual case of ectrodactyly-ectodermal dysplasia-clefting (EEC) syndrome.
  
  
  METHODS
  A single observational case report of a 22-year-old Japanese male with evaporative dry eye and corneal epithelial disease because of lipid layer abnormality resulting from meibomian gland agenesis was treated successfully with low dose lipid base ointment application.
  
  
  CONCLUSIONS
  The clinical features of the dry eye and ocular surface disease and management issues are discussed.
  
  
  CONCLUSIONS
  Low dose lipid base ointment application may be a promising treatment modality for the ocular surface disease in ectrodactyly-ectodermal dysplasia (EEC)-clefting syndrome, which seems to help in alleviating the subjective complaints and in improving the objective clinical findings.
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Ota
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Murat
authors.initials: M
authors.lastname: Dogru
authors.forename: Eiki
authors.initials: E
authors.lastname: Goto
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Uchino
authors.forename: Koji
authors.initials: K
authors.lastname: Endo
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tsubota
mesh_terms: D000328:Adult; D003316:Corneal Diseases / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D015352:Dry Eye Syndromes / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D004476:Ectodermal Dysplasia / Q000150:complications* / Q000235:genetics; D005124:Eye Abnormalities / Q000150:complications* / Q000235:genetics; D005532:Foot Deformities, Congenital / Q000150:complications* / Q000235:genetics; D006228:Hand Deformities, Congenital / Q000150:complications* / Q000235:genetics; D006801:Humans; D008055:Lipids / Q000172:deficiency; D008297:Male; D008537:Meibomian Glands / Q000002:abnormalities*; D015242:Ofloxacin / Q000008:administration & dosage; D009824:Ointments; D009883:Ophthalmic Solutions / Q000008:administration & dosage; D013577:Syndrome; D013666:Tears / Q000378:metabolism
chemical_list: D008055:Lipids; D009824:Ointments; D009883:Ophthalmic Solutions; D015242:Ofloxacin