title: The efficacy of aripiprazole in the treatment of multiple symptom domains in patients with acute schizophrenia: a pooled analysis of data from the pivotal trials.
abstract: OBJECTIVE
  To examine the efficacy of aripiprazole across symptoms in patients with acute exacerbation of schizophrenia or schizoaffective disorder.
  
  
  METHODS
  Data were pooled from five, 4-6-week acute studies. PANSS Total, Positive, Negative, and General Psychopathology Subscale improvements were analyzed, as well as all 30 individual PANSS items.
  
  
  RESULTS
  Aripiprazole had statistically significant decreases versus placebo on PANSS subscales at Week 4, similar to those seen with haloperidol. Aripiprazole-treated patients also showed significant decreases versus placebo in 26 of the 30 PANSS items (all p<0.05).
  
  
  CONCLUSIONS
  Aripiprazole demonstrates statistically and clinically significant efficacy across a range of symptoms in schizophrenia.
authors.affiliation: Department of Psychiatry, The Zucker Hillside Hospital, New York, NY, USA. psychiatry@lij.edu
authors.forename: John M
authors.initials: JM
authors.lastname: Kane
authors.forename: Sheila
authors.initials: S
authors.lastname: Assunção-Talbott
authors.forename: James M
authors.initials: JM
authors.lastname: Eudicone
authors.forename: Andrei
authors.initials: A
authors.lastname: Pikalov
authors.forename: Richard
authors.initials: R
authors.lastname: Whitehead
authors.forename: David T
authors.initials: DT
authors.lastname: Crandall
mesh_terms: D000208:Acute Disease; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D000068180:Aripiprazole; D003072:Cognition Disorders / Q000188:drug therapy / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D010879:Piperazines / Q000627:therapeutic use*; D010919:Placebos; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D015363:Quinolones / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D010879:Piperazines; D010919:Placebos; D015363:Quinolones; D000068180:Aripiprazole