Transcriptional regulation of lymphocyte development.
B lymphocytes and T lymphocytes develop from hematopoietic stem cells through a series of intermediates with progressively decreased lineage differentiation potential. Differentiation is preceded by increased accessibility of the chromatin at genes that are poised for expression in the progeny of a multipotent cell. During the process of differentiation there is increased expression of lineage-associated genes and repression of lineage-inappropriate genes resulting in commitment to differentiation through a specific lineage. These transcriptional events are coordinated by networks of transcription factors and their associated chromatin remodeling factors. The B lymphocyte lineage provides a paradigm for how these events unfold to promote specification and commitment to a single developmental pathway.
Dias
Sheila
S
Department of Pathology, The University of Chicago, Chicago, IL 60637, USA.
Xu
Wei
W
McGregor
Stephanie
S
Kee
Barbara
B
D002454:Cell Differentiation / Q000235:genetics*; D019070:Cell Lineage; D018507:Gene Expression Regulation, Developmental; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000378:metabolism; D008214:Lymphocytes / Q000166:cytology* / Q000378:metabolism; D008957:Models, Genetic; D014157:Transcription Factors / Q000378:metabolism / Q000502:physiology; D014158:Transcription, Genetic
D014157:Transcription Factors
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