Transport pathways for arsenic and selenium: a minireview.
Arsenic and selenium are metalloids found in the environment. Arsenic is considered to pose the most significant potential threat to human health based on frequency of occurrence, toxicity and human exposure. Selenium, on the other hand, ranks only 147th in toxicity but, in contrast to arsenic, is a required micronutrient. Whether a toxin or micronutrient, their metabolism requires that cells to accumulate these metalloids. In this review we discuss the membrane proteins that transport arsenic and selenium into cells, from bacteria to humans, as well as some of the efflux proteins involved in detoxification.
Rosen
Barry P
BP
Department of Biochemistry and Molecular Biology, Wayne State University, School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA. brosen@med.wayne.edu
Liu
Zijuan
Z
D000818:Animals; D001151:Arsenic / Q000378:metabolism*; D001419:Bacteria; D001692:Biological Transport; D005658:Fungi; D008322:Mammals; D026901:Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism*; D012643:Selenium / Q000378:metabolism*
D026901:Membrane Transport Proteins; D012643:Selenium; D001151:Arsenic
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