Interferon regulatory factor 4 and 8 in B-cell development.
Interferon regulatory factor 4 (IRF4) and 8 are members of the interferon regulatory factor family of transcription factors and have been shown to be essential for the development and function of T cells, macrophages and dendritic cells. A series of recent studies have further demonstrated critical functions for IRF4 and 8 at several stages of B-cell development including pre-B-cell development, receptor editing, germinal center reaction and plasma cell generation. Collectively, these new studies provide molecular insights into the function of IRF4 and 8 and underscore a requirement for IRF4 and 8 throughout B-cell development. This review focuses on the recent advances on the roles of IRF4 and 8 in B-cell development.
Lu
Runqing
R
Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198, USA. Rlu@unmc.edu
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D002454:Cell Differentiation / Q000276:immunology; D015322:Gene Rearrangement, B-Lymphocyte / Q000276:immunology; D006801:Humans; D051740:Ikaros Transcription Factor / Q000276:immunology / Q000378:metabolism*; D017578:Immunoglobulin Class Switching / Q000276:immunology; D050835:Interferon Regulatory Factors / Q000276:immunology / Q000378:metabolism*; D015851:Interleukin-7 / Q000276:immunology / Q000378:metabolism; D010950:Plasma Cells / Q000276:immunology* / Q000378:metabolism; D051560:Proto-Oncogene Proteins c-bcl-6 / Q000276:immunology / Q000378:metabolism; D000099185:Interferon Regulatory Factor-8; D000099218:Interferon Regulatory Factor-4
D051740:Ikaros Transcription Factor; D050835:Interferon Regulatory Factors; D015851:Interleukin-7; D051560:Proto-Oncogene Proteins c-bcl-6; D000099185:Interferon Regulatory Factor-8; D000099218:Interferon Regulatory Factor-4
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