title: Pacifastin-related peptides: structural and functional characteristics of a family of serine peptidase inhibitors.
abstract: Members of the pacifastin family are serine peptidase inhibitors, found in arthropods and have many members within different insect orders. Based on their structural characteristics, inhibitors of this peptide family are divided into two groups (I and II). Members of both groups exhibit specificity towards different types of serine peptidases. In addition, group I inhibitors display species selectivity. The specificity and selectivity of these inhibitors depends on the nature of their P1 residue and on additional interaction sites at the inhibitor's surface. Functional analysis studies have shown that crustacean pacifastin plays a key role in the immune response, whereas insect pacifastin-like peptides have multiple regulatory functions in processes involved in immunity, reproduction, phase transition, etc.
authors.affiliation: Department of Animal Physiology, Zoological Institute K.U. Leuven, Naamsestraat 59, B-3000 Leuven, Belgium. Bert.Breugelmans@bio.kuleuven.be
authors.forename: Bert
authors.initials: B
authors.lastname: Breugelmans
authors.forename: Gert
authors.initials: G
authors.lastname: Simonet
authors.forename: Vincent
authors.initials: V
authors.lastname: van Hoef
authors.forename: Sofie
authors.initials: S
authors.lastname: Van Soest
authors.forename: Jozef
authors.initials: J
authors.lastname: Vanden Broeck
mesh_terms: D000818:Animals; D001517:Coleoptera / Q000737:chemistry; D004175:Diptera / Q000737:chemistry; D006430:Hemiptera / Q000737:chemistry; D009987:Orthoptera / Q000737:chemistry; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000494:pharmacology*; D015842:Serine Proteinase Inhibitors / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D011506:Proteins; D015842:Serine Proteinase Inhibitors; C106709:pacifastin