Some observations on detritylation in solid-phase oligonucleotide synthesis.
The quality of oligodeoxyribonucleotides prepared by solid phase synthesis under different acid treatment time was compared. Much shorter acid delivery time did not lead to significant decrease of the full length products.
Millar
Shannon
S
Department of Chemistry, Brock University, St. Catharines, ON, L2S 3A1, Canada.
Yan
Hongbin Tony
HT
Sanghvi
Yogesh S
YS
Pon
Richard
R
D002851:Chromatography, High Pressure Liquid; D019075:Electrophoresis, Capillary; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D013936:Thymidine / Q000737:chemistry; D014320:Triphenylmethyl Compounds / Q000737:chemistry*
D009838:Oligodeoxyribonucleotides; D014320:Triphenylmethyl Compounds; D013936:Thymidine