title: 11-Hydroxymonocerin from the plant endophytic fungus Exserohilum rostratum.
abstract: A new analogue of monocerin, 11-hydroxymonocerin (2), along with monocerin (1) and 12-hydroxymonocerin (3) were isolated from cultures of Exserohilum rostratum, a fungal strain endophytic in Stemona sp. The structure of 2 was determined by analysis of NMR and MS data and by comparison of spectroscopic data to those of 1. Monocerin (1) and 11-hydroxymonocerin (2) displayed activity against Plasmodium falciparum (K1, multidrug-resistant strain) with IC50 values of 0.68 and 7.70 microM, respectively. None of the compounds were cytotoxic against any of the tumor cell lines tested.
authors.affiliation: Program in Biotechnology, Chulalongkorn University, Bangkok 10330 Thailand.
authors.forename: Ruengrit
authors.initials: R
authors.lastname: Sappapan
authors.forename: Damrong
authors.initials: D
authors.lastname: Sommit
authors.forename: Nattaya
authors.initials: N
authors.lastname: Ngamrojanavanich
authors.forename: Somchai
authors.initials: S
authors.lastname: Pengpreecha
authors.forename: Suthep
authors.initials: S
authors.lastname: Wiyakrutta
authors.forename: Nongluksna
authors.initials: N
authors.lastname: Sriubolmas
authors.forename: Khanitha
authors.initials: K
authors.lastname: Pudhom
mesh_terms: D000818:Animals; D001203:Ascomycota / Q000737:chemistry*; D018432:Drug Resistance, Multiple / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D018515:Plant Leaves / Q000382:microbiology; D010963:Plasmodium falciparum / Q000187:drug effects; D041901:Stemonaceae / Q000382:microbiology
chemical_list: C532736:11-hydroxymonocerin; D007783:Lactones; C485193:monocerin