title: Registration of 3-D CT and 2-D flat images of mouse via affine transformation.
abstract: It is difficult to directly coregister the 3-D fluorescence molecular tomography (FMT) image of a small tumor in a mouse whose maximal diameter is only a few millimeters with a larger CT image of the entire animal that spans about 10 cm. This paper proposes a new method to register 2-D flat and 3-D CT image first to facilitate the registration between small 3-D FMT images and large 3-D CT images. A novel algorithm combining differential evolution and improved simplex method for the registration between the 2-D flat and 3-D CT images is introduced and validated with simulated images and real images of mice. The visualization of the alignment of the 3-D FMT and CT image through 2-D registration shows promising results.
authors.affiliation: State Key Laboratory of Industrial Control Technology, Zhejiang University, Hangzhou 310027, China. zxia@iipc.zju.edu.cn
authors.forename: Zheng
authors.initials: Z
authors.lastname: Xia
authors.forename: Xishi
authors.initials: X
authors.lastname: Huang
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Zhou
authors.forename: Youxian
authors.initials: Y
authors.lastname: Sun
authors.forename: Vasilis
authors.initials: V
authors.lastname: Ntziachristos
authors.forename: Stephen T C
authors.initials: ST
authors.lastname: Wong
mesh_terms: D000465:Algorithms; D000818:Animals; D021621:Imaging, Three-Dimensional / Q000379:methods*; D051379:Mice; D008856:Microscopy, Fluorescence / Q000379:methods*; D013382:Subtraction Technique; D013899:Thoracic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D014057:Tomography, X-Ray Computed / Q000379:methods*