title: Thrombocytosis associated with malignant ovarian lesions within a pediatric/adolescent population.
abstract: OBJECTIVE
  To determine if there is an association between pediatric ovarian malignancies and elevated platelet counts:
  
  
  METHODS
  Retrospective chart review.
  
  
  METHODS
  Large referral children's hospital.
  
  
  METHODS
  154 patients taken to the operating room between February 1993 and February 2006 with an adnexal mass where ovarian tissue was submitted for pathological analysis.
  
  
  METHODS
  The principle outcome was the presence of ovarian malignancy.
  
  
  RESULTS
  We found that there is an increase in thrombocytosis among individuals with ovarian malignancy, with as high as 33% of those with ovarian germ cell tumors demonstrating preoperative thrombocytosis.
  
  
  CONCLUSIONS
  These results suggest that thrombocytosis may be a useful marker for ovarian malignancy in this population. Further studies will be needed to determine if there is any prognostic value to thrombocytosis among these patients, with a potential value for counseling and future intervention based on these findings.
authors.affiliation: Division of Gynecology, Department of Surgery, Children's Hospital Boston, Boston, Massachusetts 02115, USA.
authors.forename: L B
authors.initials: LB
authors.lastname: Haddad
authors.forename: M R
authors.initials: MR
authors.lastname: Laufer
mesh_terms: D000293:Adolescent; D014408:Biomarkers, Tumor / Q000097:blood; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010049:Ovarian Diseases / Q000097:blood* / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D010051:Ovarian Neoplasms / Q000097:blood* / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D010976:Platelet Count; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D013922:Thrombocytosis / Q000453:epidemiology / Q000209:etiology*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor