The osteoarthritis initiative: report on the design rationale for the magnetic resonance imaging protocol for the knee.
OBJECTIVE
To report on the process and criteria for selecting acquisition protocols to include in the osteoarthritis initiative (OAI) magnetic resonance imaging (MRI) study protocol for the knee.


METHODS
Candidate knee MR acquisition protocols identified from the literature were first optimized at 3Tesla (T). Twelve knees from 10 subjects were scanned one time with each of 16 acquisitions considered most likely to achieve the study goals and having the best optimization results. The resultant images and multi-planar reformats were evaluated for artifacts and structural discrimination of articular cartilage at the cartilage-fluid, cartilage-fat, cartilage-capsule, cartilage-meniscus and cartilage-cartilage interfaces.


RESULTS
The five acquisitions comprising the final OAI MRI protocol were assembled based on the study goals for the imaging protocol, the image evaluation results and the need to image both knees within a 75 min time slot, including positioning. For quantitative cartilage morphometry, fat-suppressed, 3D dual-echo in steady state (DESS) acquisitions appear to provide the best universal cartilage discrimination.


CONCLUSIONS
The OAI knee MRI protocol provides imaging data on multiple articular structures and features relevant to knee OA that will support a broad range of existing and anticipated measurement methods while balancing requirements for high image quality and consistency against the practical considerations of a large multi-center cohort study. Strengths of the final knee MRI protocol include cartilage quantification capabilities in three planes due to multi-planar reconstruction of a thin slice, high spatial resolution 3D DESS acquisition and the multiple, non-fat-suppressed image contrasts measured during the T2 relaxation time mapping acquisition.
Peterfy
C G
CG
Synarc Inc, San Francisco, CA 94105, USA. charles.peterfy@synarc.com
Schneider
E
E
Nevitt
M
M
D000368:Aged; D002358:Cartilage, Articular / Q000473:pathology*; D002985:Clinical Protocols; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D021621:Imaging, Three-Dimensional; D007719:Knee Joint / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
NMR Biomed. 2006 Nov;19(7):781-821
17075961
Osteoarthritis Cartilage. 2006;14 Suppl A:A76-86
16716605
Radiology. 1997 Nov;205(2):546-50
9356643
Ann Rheum Dis. 2006 Apr;65(4):433-41
16126797
Osteoarthritis Cartilage. 2007 May;15(5):487-92
17188525
Osteoarthritis Cartilage. 2006;14 Suppl A:A95-111
16750915
AJR Am J Roentgenol. 2004 Aug;183(2):343-51
15269023
NMR Biomed. 2006 Nov;19(7):822-54
17075958
Ann Rheum Dis. 2009 Mar;68(3):349-56
18408248
Arthritis Rheum. 2005 Oct;52(10):3132-6
16200592
Surg Radiol Anat. 1994;16(4):429-38
7725201
Magn Reson Med. 2003 Dec;50(6):1229-36
14648571
AJR Am J Roentgenol. 2002 Jun;178(6):1568-9; author reply 1569-70
12034642
Osteoarthritis Cartilage. 2006;14 Suppl A:A10-3
16785055
Semin Musculoskelet Radiol. 2004 Dec;8(4):355-68
15643574
Ann Intern Med. 2003 Sep 2;139(5 Pt 1):330-6
12965941
J Magn Reson Imaging. 1996 Mar-Apr;6(2):329-35
9132098
Clin Orthop Relat Res. 2004 Oct;(427 Suppl):S175-81
15480063
Osteoarthritis Cartilage. 2007 Nov;15(11):1326-32
17560813
Osteoarthritis Cartilage. 2006;14 Suppl A:A46-75
16713720
Magn Reson Med. 2007 Feb;57(2):448-54
17260363
Arthritis Rheum. 2004 Jan;50(1):94-7
14730604
Semin Musculoskelet Radiol. 2004 Dec;8(4):329-53
15643573
J Magn Reson Imaging. 2000 Jun;11(6):678-85
10862068
Osteoarthritis Cartilage. 2006 Nov;14(11):1087-90
16901724
Ann Intern Med. 2001 Apr 3;134(7):541-9
11281736
J Orthop Res. 2008 Mar;26(3):281-91
17876836
Radiographics. 1997 Nov-Dec;17(6):1387-402
9397453
Curr Opin Rheumatol. 2007 Sep;19(5):435-43
17762608
J Bone Joint Surg Am. 1998 Sep;80(9):1276-84
9759811
Arthritis Rheum. 2004 Mar;50(3):811-6
15022323
Med Phys. 1984 Jul-Aug;11(4):425-48
6482839