Chemical models and their mechanistic implications for the transformation of 6-cyanouridine 5'-monophosphate catalyzed by orotidine 5'-monophosphate decarboxylase.
Orotidine 5'-monophosphate decarboxylase (ODCase) catalyzes an unprecedented transformation of 6- cyanouridine 5'-monophosphate (6-CN-UMP) into barbiturate nucleoside 5'-monophosphate (6-hydroxyuridine 5'-monophosphate, BMP). The reactions of 6- cyano-1,3-dimethyluracil toward various nucleophilic conditions have been studied as chemical models in order to understand the possible mechanism for the ODCase-catalyzed transformation of 6-CN-UMP.
Chien
Tun-Cheng
TC
Department of Chemistry, College of Science, National Taiwan Normal University, Taipei 11677, Taiwan. tcchien@ntnu.edu.tw
Jen
Cheng-Hung
CH
Wu
Yuen-Jen
YJ
Liao
Chen-Chieh
CC
D001463:Barbiturates / Q000737:chemistry; D002384:Catalysis; D008956:Models, Chemical; D009964:Orotidine-5'-Phosphate Decarboxylase / Q000737:chemistry* / Q000378:metabolism; D014542:Uridine Monophosphate / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism
C513367:6-cyanouridine 5'-O-monophosphate; C541623:6-hydroxyuridine 5'-monophosphate; D001463:Barbiturates; D014542:Uridine Monophosphate; D009964:Orotidine-5'-Phosphate Decarboxylase