[Fabrication, characterization and drug release characteristics of drug loaded poly (L-lactic acid) fiber].
To develop a long-term released and implantable biodegradable fiber carrier for hydrophobic drug incorporation, fibers were fabricated by organic phase separation method. The structure of the fiber was observed by scanning electron microscopy and the state of the drug dispersed in the polymer was measured by differential scanning colorimetry (DSC) and Fouvier transform infrared spectroscopy (FTIR). The drug loading content and release profiles were determined by high performance liquid chromatography (HPLC) and ultra-violet spectrophotometry, respectively. Blank and drug loaded fibers were successfully fabricated and the drug was entirely encapsulated into the fiber. The drug was dispersed in the polymer with minicrystal and noncrystal form. The drug release profile was long-term sustained and could be regulated. The PLLA fibers in micrometer range successfully fabricated by organic phase separation method could be taken as sustained release and implantable drug carrier.
Gao
Hao
H
Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210038, China.
Ping
Qineng
Q
Gu
Yueqing
Y
D020341:Absorbable Implants; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry; D004343:Drug Implants / Q000008:administration & dosage / Q000138:chemical synthesis*; D019344:Lactic Acid / Q000008:administration & dosage* / Q000737:chemistry; D009553:Nimodipine / Q000008:administration & dosage; D011091:Polyesters; D011108:Polymers / Q000008:administration & dosage* / Q000737:chemistry
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004343:Drug Implants; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D009553:Nimodipine