Structural insights into the mechanisms of antibody-mediated neutralization of flavivirus infection: implications for vaccine development.
Flaviviruses are a group of small RNA viruses that cause severe disease in humans worldwide and are the target of several vaccine development programs. A primary goal of these efforts is to elicit a protective humoral response directed against the envelope proteins arrayed on the surface of the flavivirus virion. Advances in the structural biology of these viruses has catalyzed rapid progress toward understanding the complexity of the flavivirus immunogen and the molecular basis of antibody-mediated neutralization. These insights have identified factors that govern the potency of neutralizing antibodies and will inform the design and evaluation of novel vaccines.
Pierson
Theodore C
TC
Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institutes of Health, 33 North Drive, Building 33, Room 1E19A.2, Bethesda, MD 20892, USA. piersontc@mail.nih.gov
Fremont
Daved H
DH
Kuhn
Richard J
RJ
Diamond
Michael S
MS
D000914:Antibodies, Viral / Q000276:immunology*; D000956:Antigens, Viral / Q000737:chemistry / Q000276:immunology; D003167:Complement Activation; D005416:Flavivirus / Q000737:chemistry* / Q000276:immunology*; D018177:Flavivirus Infections / Q000276:immunology* / Q000628:therapy; D006801:Humans; D018448:Models, Immunological; D014759:Viral Envelope Proteins / Q000737:chemistry / Q000276:immunology; D014765:Viral Vaccines / Q000737:chemistry* / Q000276:immunology*
D000914:Antibodies, Viral; D000956:Antigens, Viral; D014759:Viral Envelope Proteins; D014765:Viral Vaccines
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