Quality of life, anxiety and depression in sarcoidosis.
OBJECTIVE
This study sought to evaluate the quality of life and the presence of psychiatric disorders in patients with sarcoidosis.


METHODS
Data were collected from 80 consecutive outpatients with sarcoidosis presenting to the Sarcoidosis Center of the Respiratory Diseases Division at the University of Siena, Italy.


RESULTS
Forty-four percent of the subjects endorsed at least one psychiatric DSM-IV axis I diagnosis. Specifically, 25% of subjects met the criteria for Major Depressive Disorder, 6.3% for Panic Disorder, 6.3% for Bipolar Disorder, 5% for Generalized Anxiety Disorder and 1.3% for Obsessive Compulsive Disorder. Statistically significant correlations were found between Forced Expiratory Volume in the first second (FEV(1)), Forced Vital Capacity (FVC) and several domains of the Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q) questionnaire. Subjects with multi-systemic involvement, with asthenia and with a more severe radiographic stage and subjects receiving steroids, reported a poorer quality of life.


CONCLUSIONS
Sarcoidosis is associated with a high rate of psychiatric comorbidity and may contribute to a poorer quality of life. A referral for a psychiatric or psychological evaluation and counseling should be considered for many of the sarcoidosis patients.
Goracci
Arianna
A
Psychiatry Division, Department of Neuroscience, University of Siena School of Medicine, Viale Bracci 1, 53100 Siena, Italy. goracci3@unisi.it
Fagiolini
Andrea
A
Martinucci
Mirko
M
Calossi
Sara
S
Rossi
Serena
S
Santomauro
Tonino
T
Mazzi
Angela
A
Penza
Francesco
F
Fossi
Antonella
A
Bargagli
Elena
E
Pieroni
Maria Grazia
MG
Rottoli
Paola
P
Castrogiovanni
Paolo
P
D000203:Activities of Daily Living / Q000523:psychology; D000328:Adult; D001008:Anxiety Disorders / Q000175:diagnosis* / Q000523:psychology; D001247:Asthenia / Q000175:diagnosis / Q000523:psychology; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000523:psychology; D003865:Major Depressive Disorder / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000523:psychology; D016584:Panic Disorder / Q000175:diagnosis / Q000523:psychology; D011788:Quality of Life / Q000523:psychology*; D012507:Sarcoidosis / Q000175:diagnosis / Q000523:psychology*; D017565:Sarcoidosis, Pulmonary / Q000175:diagnosis / Q000523:psychology*; D012803:Sick Role; D014797:Vital Capacity