title: Time constants of h current in layer ii stellate cells differ along the dorsal to ventral axis of medial entorhinal cortex.
abstract: Chronic recordings in the medial entorhinal cortex of behaving rats have found grid cells, neurons that fire when the rat is in a hexagonal array of locations. Grid cells recorded at different dorsal-ventral anatomical positions show systematic changes in size and spacing of firing fields. To test possible mechanisms underlying these differences, we analyzed properties of the hyperpolarization-activated cation current I(h) in voltage-clamp recordings from stellate cells in entorhinal slices from different dorsal-ventral locations. The time constant of h current was significantly different between dorsal and ventral neurons. The time constant of h current correlated with membrane potential oscillation frequency and the time constant of the sag potential in the same neurons. Differences in h current could underlie differences in membrane potential oscillation properties and contribute to grid cell periodicity along the dorsal-ventral axis of medial entorhinal cortex.
authors.affiliation: Center for Memory and Brain, Program in Neuroscience and Department of Psychology, Boston University, Boston, Massachusetts 02215, USA. giocomo@gmail.com
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Giocomo
authors.forename: Michael E
authors.initials: ME
authors.lastname: Hasselmo
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001683:Biological Clocks / Q000502:physiology; D027682:Cation Transport Proteins / Q000502:physiology; D018728:Entorhinal Cortex / Q000166:cytology / Q000502:physiology*; D005260:Female; D007395:Interneurons / Q000502:physiology*; D007473:Ion Channels / Q000502:physiology; D008297:Male; D008564:Membrane Potentials / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D009924:Organ Culture Techniques; D018408:Patch-Clamp Techniques; D051381:Rats; D020318:Rats, Long-Evans; D009435:Synaptic Transmission / Q000502:physiology; D013997:Time Factors
chemical_list: D027682:Cation Transport Proteins; D007473:Ion Channels
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