title: Suzuki-Miyaura coupling of aryl tosylates catalyzed by an array of indolyl phosphine-palladium catalysts.
abstract: A family of indolyl phosphine ligands was applied to Suzuki-Miyaura cross-coupling of aryl tosylates. Catalyst loading can be reduced to 0.2 mol % for coupling of nonactivated aryl tosylate. A challenging example for room temperature coupling is realized. The scope of this highly active Pd/L2 system can be extended to other boron nucleophiles, including trifluoroborate salts and boronate esters. The ligand structural comparisons toward the reactivity in tosylate couplings are also described.
authors.affiliation: Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
authors.forename: Chau Ming
authors.initials: CM
authors.lastname: So
authors.forename: Chak Po
authors.initials: CP
authors.lastname: Lau
authors.forename: Albert S C
authors.initials: AS
authors.lastname: Chan
authors.forename: Fuk Yee
authors.initials: FY
authors.lastname: Kwong