title: Acute exercise increases expression of extracellular superoxide dismutase in skeletal muscle and the aorta.
abstract: Exercise dramatically increases oxygen consumption and causes oxidative stress. Superoxide dismutase (SOD) is important in the first-line defence mechanisms against oxidative stress. To investigate the effect of acute exercise on the expression of SOD, we examined the expression of mRNA for three SOD isozymes, in mice run on a treadmill to exhaustion. Six hours after exercise, the expression of extracellular SOD (EC-SOD) mRNA increased significantly in skeletal muscle and persisted for 24 h, whereas no change was observed for cytoplasmic and mitochondrial SOD mRNA. Moreover, acute exercise also induced EC-SOD mRNA in the aorta. These results suggest that a single bout of exercise is enough to augment the expression EC-SOD mRNA in skeletal muscle and the aorta, and may partly explain the beneficial effect of exercise.
authors.affiliation: Department of Molecular Predictive Medicine and Sport Science, School of Medicine, Kyorin University, Mitaka, Tokyo, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Hitomi
authors.forename: Sumiko
authors.initials: S
authors.lastname: Watanabe
authors.forename: Takako
authors.initials: T
authors.lastname: Kizaki
authors.forename: Takuya
authors.initials: T
authors.lastname: Sakurai
authors.forename: Tohru
authors.initials: T
authors.lastname: Takemasa
authors.forename: Shukoh
authors.initials: S
authors.lastname: Haga
authors.forename: Tomomi
authors.initials: T
authors.lastname: Ookawara
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Suzuki
authors.forename: Hideki
authors.initials: H
authors.lastname: Ohno
mesh_terms: D000818:Animals; D001011:Aorta / Q000201:enzymology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018482:Muscle, Skeletal / Q000201:enzymology*; D005082:Physical Exertion; D012333:RNA, Messenger / Q000378:metabolism; D013482:Superoxide Dismutase / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D012333:RNA, Messenger; C499090:Sod3 protein, mouse; D013482:Superoxide Dismutase