Laminar analysis of the role of GluR1 in experience-dependent and synaptic depression in barrel cortex.
Several synaptic depression mechanisms have been described for the hippocampus, cerebellum and neocortex in vitro, but little is known about which, if any, are engaged during experience-dependent depression (EDD). We found that EDD in the mouse barrel cortex depends on the AMPA subunit GluR1 in layers II/III and IV, but not in layer V, and that long-term depression is also GluR1 dependent in the IV-II/III, but not II/III-V, pathway.
Wright
Nicholas
N
Cardiff School of Biosciences, Cardiff University, Cardiff CF103US, UK.
Glazewski
Stanislaw
S
Hardingham
Neil
N
Phillips
Keith
K
Pervolaraki
Eleftheria
E
Fox
Kevin
K
D000704:Analysis of Variance; D000818:Animals; D036881:Long-Term Synaptic Depression / Q000235:genetics / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D018091:Receptors, AMPA / Q000172:deficiency / Q000502:physiology*; D012683:Sensory Deprivation / Q000502:physiology; D013003:Somatosensory Cortex / Q000033:anatomy & histology* / Q000502:physiology*; D009435:Synaptic Transmission / Q000235:genetics / Q000502:physiology*; D014738:Vibrissae / Q000294:innervation
D018091:Receptors, AMPA
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