title: Encoded and multiplexed surface plasmon resonance sensor platform.
abstract: We present a flexible new sensor system that combines the joint advantages of (i) discretely functionalized, code-bearing, microparticles and (ii) label-free detection using grating-coupled surface plasmon resonance. This system offers the possibility of simultaneously investigating the real-time binding kinetics of a variety of molecular interactions. One single multiplexed assay could employ a wide range of immobilization chemistries, surface preparation methods, and formats. Thus, the new system offers a very high level of assay conformability to the end user, particularly when compared to fixed microarrays.
authors.affiliation: Cambridge Research Laboratory, Toshiba Research Europe Limited, 208 Cambridge Science Park, Milton Road, Cambridge, UK.
authors.forename: Katja F
authors.initials: KF
authors.lastname: Kastl
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Lowe
authors.forename: Carl E
authors.initials: CE
authors.lastname: Norman
mesh_terms: D003365:Costs and Cost Analysis; D006801:Humans; D011485:Protein Binding; D012680:Sensitivity and Specificity; D012822:Silicon Dioxide / Q000737:chemistry; D020349:Surface Plasmon Resonance / Q000191:economics / Q000295:instrumentation* / Q000379:methods*; D013997:Time Factors
chemical_list: D012822:Silicon Dioxide