A convenient approach towards 2'-O-modified RNA-oligonucleotides on solid support using universal nucleosides.
Here we report a novel synthetic pathway for an efficient modification of RNA-oligonucleotides on solid-support using universal nucleosides bearing a 2'-O-aminopropyl-tether.
Haas
Jens
J
Johann Wolfgang Goethe-University Frankfurt, Department of Chemistry, D-60438 Frankfurt am Main, Germany.
Engels
Joachim W
JW
D000577:Amides / Q000737:chemistry; D001671:Biochemistry / Q000379:methods; D002264:Carboxylic Acids / Q000737:chemistry; D009705:Nucleosides / Q000737:chemistry*; D009843:Oligoribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D010756:Phosphoric Acids / Q000737:chemistry
D000577:Amides; D002264:Carboxylic Acids; D009705:Nucleosides; D009843:Oligoribonucleotides; D010756:Phosphoric Acids; C011067:phosphoramidic acid