title: A short C-rich PNA fragment capable to form novel G-quadruplex-PNA complexes.
abstract: In this work we investigated the interaction between the short ac(4)a C-rich peptide nucleic acid (PNA) probe and two intramolecular G-quadruplex targets having the same G-tetrad core, but different folding topologies. The T(G(4)T)(3)G(4)T and the recently reported tetra-end-linked-(TG(4)T)(4) G-rich oligonucleotides (GROs) were chosen and synthesized for this study. UV, CD, and MS experiments revealed the formation of novel 1:1 G-quadruplex-PNA complexes besides the expected DNA-PNA heteroduplexes.
authors.affiliation: Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Via D. Montesano 49, I-80131 Napoli, Italy.
authors.forename: Jussara
authors.initials: J
authors.lastname: Amato
authors.forename: Valérie
authors.initials: V
authors.lastname: Gabelica
authors.forename: Nicola
authors.initials: N
authors.lastname: Borbone
authors.forename: Frédéric
authors.initials: F
authors.lastname: Rosu
authors.forename: Edwin
authors.initials: E
authors.lastname: De Pauw
authors.forename: Giorgia
authors.initials: G
authors.lastname: Oliviero
authors.forename: Gennaro
authors.initials: G
authors.lastname: Piccialli
authors.forename: Luciano
authors.initials: L
authors.lastname: Mayol
mesh_terms: D002942:Circular Dichroism; D003596:Cytosine / Q000737:chemistry; D054856:G-Quadruplexes; D009841:Oligonucleotides / Q000737:chemistry; D020135:Peptide Nucleic Acids / Q000737:chemistry*
chemical_list: D009841:Oligonucleotides; D020135:Peptide Nucleic Acids; D003596:Cytosine