From cochlear cell death pathways to new pharmacological therapies.
Ototoxic drugs, intense sound or age-related hearing loss recruit most of the apoptotic pathways, but also several additional enzymatic pathways which eventually result in cell death. Here, we discuss therapeutic strategies based on the inhibition of regulators or executors of apoptotic cell death pathways and on the use of antioxidants.
Wang
Jing
J
INSERM U 583, Laboratoire de Physiopathologie et thérapie des déficits sensoriels et moteurs, Montpellier, France.
Puel
Jean-Luc
JL
D000367:Age Factors; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects*; D003051:Cochlea / Q000293:injuries / Q000503:physiopathology*; D015195:Drug Design; D006319:Hearing Loss, Sensorineural / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D015398:Signal Transduction / Q000187:drug effects
D000975:Antioxidants