Genoketides A1 and A2, new octaketides and biosynthetic intermediates of chrysophanol produced by Streptomyces sp. AK 671.
The new aromatic polyketides genoketide A1, genoketide A2 and prechrysophanol glucuronide are biosynthetic intermediates of the octaketide chrysophanol. They were isolated from the alkaliphilic strain Streptomyces sp. AK 671 together with the new metabolite chrysophanol glucuronide. The structures of the compounds were elucidated by mass spectrometry and NMR methods. Genoketide A2 exhibited a slight and prechrysophanol glucuronide a more pronounced inhibition of the proliferation of L5178y lymphoma cells.
Fiedler
Hans-Peter
HP
Mikrobiologisches Institut, Universität Tübingen, Tübingen, Germany. hans-peter.fiedler@uni-tuebingen.de
Dieter
Anke
A
Gulder
Tobias A M
TA
Kajahn
Inga
I
Hamm
Andreas
A
Brown
Ros
R
Jones
Amanda L
AL
Goodfellow
Michael
M
Müller
Werner E G
WE
Bringmann
Gerhard
G
D000880:Anthraquinones / Q000378:metabolism*; D000903:Antibiotics, Antineoplastic / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D018942:Macrolides / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D013302:Streptomyces / Q000378:metabolism*
D000880:Anthraquinones; D000903:Antibiotics, Antineoplastic; D018942:Macrolides; C027113:chrysophanic acid