title: Water-assisted femtosecond laser machining of electrospray nozzles on glass microfluidic devices.
abstract: Using water-assisted femtosecond laser machining, we fabricated electrospray nozzles on glass coverslips and on assembled microfluidic devices. Machining the nozzles after device assembly facilitated alignment of the nozzles over the microchannels. The basic nozzle design is a through-hole in the coverslip to pass liquids and a trough machined around the through-hole to confine the electrospray and prevent liquid from wicking across the glass surface. Electrospray from the nozzles was stable with and without pressure-driven flow applied and was evaluated using mass spectra of the peptide bradykinin.
authors.affiliation: Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Ran
authors.initials: R
authors.lastname: An
authors.forename: Michelle D
authors.initials: MD
authors.lastname: Hoffman
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Donoghue
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Hunt
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Jacobson
mesh_terms: D004867:Equipment Design; D019544:Equipment Failure Analysis; D017022:Flow Injection Analysis / Q000295:instrumentation*; D005898:Glass / Q000737:chemistry* / Q000528:radiation effects*; D007834:Lasers; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D055672:Static Electricity; D014867:Water
chemical_list: D014867:Water