title: The future of pediatric acute kidney injury management--biomarkers.
abstract: Acute kidney injury (AKI) represents a common and devastating problem in clinical medicine. A major reason is the lack of early biomarkers for AKI, and hence an unacceptable delay in initiating therapy. Fortunately, the application of innovative technologies has uncovered several novel biomarkers. The most promising of these are included in a putative AKI biomarker panel, consisting of neutrophil gelatinase-associated lipocalin, interleukin-18, and kidney injury molecule-1. These biomarkers have completed initial validation, and have entered the prospective screening stage in the biomarker development process, facilitated by the development of commercial tools for their reproducible measurement across laboratories. The availability of a panel of validated biomarkers will revolutionize renal and critical care, and enable the practice of personalized and predictive medicine at an unprecedented level.
authors.affiliation: Departments of Pediatrics and Developmental Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA. prasad.devarajan@cchmc.org
authors.forename: Prasad
authors.initials: P
authors.lastname: Devarajan
mesh_terms: D058186:Acute Kidney Injury / Q000378:metabolism*; D015415:Biomarkers / Q000032:analysis*; D002648:Child; D006801:Humans; D011379:Prognosis; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers
references.citation: J Clin Invest. 2001 May;107(9):1145-52
references.pmid: 11342578
references.citation: J Am Soc Nephrol. 2006 Jun;17(6):1503-20
references.pmid: 16707563
references.citation: Am J Physiol Renal Physiol. 2006 Feb;290(2):F517-29
references.pmid: 16174863
references.citation: J Am Soc Nephrol. 2005 Oct;16(10):3046-52
references.pmid: 16148039
references.citation: J Pathol. 2007 Jun;212(2):209-17
references.pmid: 17471468
references.citation: Crit Care. 2007;11(4):R84
references.pmid: 17678545
references.citation: Curr Opin Nephrol Hypertens. 2008 Mar;17(2):127-32
references.pmid: 18277143
references.citation: Pediatr Nephrol. 2006 Jul;21(7):989-94
references.pmid: 16773412
references.citation: J Am Soc Nephrol. 2007 Mar;18(3):904-12
references.pmid: 17267747
references.citation: Cancer Ther. 2007;5(B):463-470
references.pmid: 18449360
references.citation: Pediatr Nephrol. 2008 Dec;23(12):2151-7
references.pmid: 17394022
references.citation: Crit Care. 2007;11(6):R127
references.pmid: 18070344
references.citation: Pediatr Nephrol. 2007 Dec;22(12):2089-95
references.pmid: 17874137
references.citation: Am J Nephrol. 2004 May-Jun;24(3):307-15
references.pmid: 15148457
references.citation: Kidney Int. 2006 Jul;70(1):199-203
references.pmid: 16710348
references.citation: Am J Transplant. 2006 Jul;6(7):1639-45
references.pmid: 16827865
references.citation: Am J Physiol Renal Physiol. 2004 Mar;286(3):F552-63
references.pmid: 14600030
references.citation: Clin J Am Soc Nephrol. 2008 May;3(3):665-73
references.pmid: 18337554
references.citation: Annu Rev Pharmacol Toxicol. 2008;48:463-93
references.pmid: 17937594
references.citation: Pediatr Nephrol. 2006 Jun;21(6):856-63
references.pmid: 16528543
references.citation: J Surg Res. 2008 Mar;145(1):170-5
references.pmid: 17658553
references.citation: Am J Kidney Dis. 2004 Mar;43(3):405-14
references.pmid: 14981598
references.citation: J Am Soc Nephrol. 2003 Oct;14(10):2534-43
references.pmid: 14514731
references.citation: Crit Care. 2007;11(3):141
references.pmid: 17581273
references.citation: Semin Nephrol. 2007 Nov;27(6):637-51
references.pmid: 18061846
references.citation: J Am Soc Nephrol. 2005 Nov;16(11):3365-70
references.pmid: 16177006
references.citation: J Biol Chem. 1998 Feb 13;273(7):4135-42
references.pmid: 9461608
references.citation: Kidney Int. 2002 Jul;62(1):237-44
references.pmid: 12081583
references.citation: Transplantation. 2007 Jul 15;84(1):104-12
references.pmid: 17627245
references.citation: Lancet. 2005 Apr 2-8;365(9466):1231-8
references.pmid: 15811456
references.citation: Kidney Int. 2003 May;63(5):1714-24
references.pmid: 12675847
references.citation: Toxicol Sci. 2008 Jan;101(1):159-70
references.pmid: 17934191
references.citation: N Engl J Med. 2008 Jan 17;358(3):312; author reply 313
references.pmid: 18203334
references.citation: Contrib Nephrol. 2007;156:203-12
references.pmid: 17464129
references.citation: Kidney Int. 2008 Feb;73(4):465-72
references.pmid: 18094680
references.citation: Kidney Int. 2008 Apr;73(7):863-9
references.pmid: 18059454
references.citation: Nephrol Dial Transplant. 2008 Feb;23(2):566-72
references.pmid: 17911094