Role of crosstalk between phosphatidylinositol 3-kinase and extracellular signal-regulated kinase/mitogen-activated protein kinase pathways in artery-vein specification.
Functional and structural differences between arteries and veins lie at the core of the circulatory system, both in health and disease. Therefore, understanding how artery and vein cell identities are established is a fundamental biological challenge with significant clinical implications. Molecular genetic studies in zebrafish and other vertebrates in the past decade have begun to reveal in detail the complex network of molecular pathways that specify artery and vein cell fates during embryonic development. Recently, a chemical genetic approach has revealed evidence that artery-vein specification is governed by cross talk between phosphoinositide 3-kinase and extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) signaling in artery-vein specification. We discuss recent findings on the signaling pathways involved in artery-vein specification during zebrafish development and compare and contrast these results to those from mammalian systems. It is anticipated that the complementary approaches of genetics and chemical biology, involving a variety of model organisms and systems, will lead to a better understanding of artery-vein specification and possibly to novel therapeutic approaches to treat vascular diseases.
Hong
Charles C
CC
Division of Cardiovascular Medicine, Vanderbilt University Medical Center, 383 PRB, 2220 Pierce Ave, Nashville, TN 37232, USA. charles.c.hong@vanderbilt.edu
Kume
Tsutomu
T
Peterson
Randall T
RT
D000818:Animals; D001158:Arteries / Q000166:cytology / Q000201:enzymology* / Q000254:growth & development; D002450:Cell Communication / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology; D048049:Extracellular Signal-Regulated MAP Kinases / Q000502:physiology*; D006801:Humans; D020935:MAP Kinase Signaling System / Q000502:physiology*; D020928:Mitogen-Activated Protein Kinases / Q000502:physiology*; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology*; D014680:Veins / Q000166:cytology / Q000201:enzymology* / Q000254:growth & development
D019869:Phosphatidylinositol 3-Kinases; D048049:Extracellular Signal-Regulated MAP Kinases; D020928:Mitogen-Activated Protein Kinases
Cell. 2000 Jul 21;102(2):131-4
10943832
Dev Biol. 2001 Sep 15;237(2):398-409
11543623
Dev Cell. 2005 Mar;8(3):389-400
15737934
J Clin Invest. 2002 Feb;109(3):327-36
11827992
Genes Dev. 2003 Jun 1;17(11):1346-51
12782653
Development. 2004 Sep;131(17):4371-80
15294868
Dev Cell. 2006 Jun;10(6):783-95
16740480
Science. 1999 Nov 26;286(5445):1741-4
10576742
Nat Med. 2001 Jun;7(6):706-11
11385508
Dev Biol. 1997 Mar 1;183(1):37-48
9119113
Development. 2001 Oct;128(19):3675-83
11585794
J Biol Chem. 2002 Mar 15;277(11):9335-41
11744703
Arterioscler Thromb Vasc Biol. 2007 Mar;27(3):487-93
17185616
Nature. 1996 Oct 3;383(6599):407-13
8837770
PLoS One. 2008 Jun 11;3(6):e2401
18545664
Nature. 2001 Nov 8;414(6860):216-20
11700560
Development. 2005 Mar;132(5):941-52
15673567
Genes Dev. 2004 Apr 15;18(8):901-11
15107403
J Biol Chem. 2001 Sep 7;276(36):33428-34
11445586
Genes Dev. 2007 Oct 15;21(20):2511-24
17938237
Genes Dev. 2004 Oct 15;18(20):2474-8
15466159
J Morphol. 2000 Jun;244(3):167-76
10815000
Circ Res. 2006 Sep 15;99(6):656-62
16931799
Oncogene. 1999 Apr 1;18(13):2221-30
10327068
Development. 2002 Jan;129(2):361-72
11807029
Nat Rev Genet. 2002 Sep;3(9):717-24
12209146
Nat Biotechnol. 2004 May;22(5):595-9
15097998
Development. 2001 Sep;128(17):3359-70
11546752
Mol Cell Biol. 2003 Jan;23(1):14-25
12482957
Curr Opin Hematol. 2008 May;15(3):221-7
18391789
Curr Biol. 2006 Jul 11;16(13):1366-72
16824925
Dev Biol. 1998 May 15;197(2):248-69
9630750
Nature. 2005 Dec 15;438(7070):937-45
16355211
Nature. 2005 May 5;435(7038):98-104
15875024
Dev Biol. 2006 Jun 15;294(2):458-70
16678147
Cardiovasc Res. 2001 Feb 16;49(3):568-81
11166270
N Engl J Med. 1995 Oct 5;333(14):918-24
7666879
Development. 1998 Oct;125(19):3905-14
9729498
Annu Rev Physiol. 1996;58:483-507
8815804
Mech Dev. 2001 Oct;108(1-2):161-4
11578869
Circ Res. 2007 Feb 16;100(3):363-71
17234965
Nature. 1996 Apr 4;380(6573):435-9
8602241
Science. 2002 Jan 18;295(5554):457-62
11799232
Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6554-9
16617120
Dev Cell. 2002 Jul;3(1):127-36
12110173
Sci STKE. 2006 Oct 03;2006(355):pe39
17018851
Curr Top Dev Biol. 2003;53:1-114
12509125
Development. 2004 Jan;131(2):361-75
14681188
Nat Rev Genet. 2002 Sep;3(9):674-82
12209142
Development. 2003 Oct;130(19):4527-37
12925581