title: Does previous fundoplication alter the surgical approach to esophageal adenocarcinoma?
abstract: OBJECTIVE
  The primary aim of this study was to test the widespread assumption that the viability of the gastric fundus is compromised by fundoplication, thereby limiting the use of stomach to reconstruct the upper gastrointestinal tract after esophageal resection.
  
  
  METHODS
  Between February 1991 and February 2006, a consecutive series of 142 patients with esophageal adenocarcinoma (EADC) underwent esophageal resection. To reconstruct the upper gastrointestinal tract, all patients had a narrow gastric tube (greater curvature of stomach based on the right gastroepiploic artery) transposed through the posterior mediastinum to the left neck where an anastomosis to the cervical esophagus was performed. From a prospective database, 15 patients were identified to have undergone an 'open' fundoplication (transabdominal Nissen, n=11; transthoracic Belsey, n=4) from 12 to 23 years earlier. Outcomes were compared between patients with EADC who had undergone previous fundoplication, and patients with EADC who never had antireflux surgery.
  
  
  RESULTS
  Gastric transposition and cervical esophagogastrostomy were technically feasible in all patients. No significant differences in outcome were found between patient groups. Gastric necrosis developed in only one patient, who had not undergone previous fundoplication. Anastomotic leak rates after esophageal resection and reconstruction were not statistically different based on whether patients had undergone previous fundoplication (2/15, 13.3%) or not (16/127, 12.6%; p=0.99).
  
  
  CONCLUSIONS
  With careful attention to surgical technique, previous fundoplication does not preclude the use of stomach to reconstruct the foregut after esophageal resection, refuting the notion that previous antireflux surgery is a relative contraindication to, or alters the approach to esophageal cancer surgery.
authors.affiliation: Department of Surgery, Royal University Hospital and the College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. alan.casson@usask.ca
authors.forename: Alan G
authors.initials: AG
authors.lastname: Casson
authors.forename: Koroush
authors.initials: K
authors.lastname: Madani
authors.forename: Sarika
authors.initials: S
authors.lastname: Mann
authors.forename: Ronghua
authors.initials: R
authors.lastname: Zhao
authors.forename: Bruce
authors.initials: B
authors.lastname: Reeder
authors.forename: Hyun Ja
authors.initials: HJ
authors.lastname: Lim
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000714:Anastomosis, Surgical / Q000009:adverse effects / Q000379:methods; D000075202:Contraindications; D004938:Esophageal Neoplasms / Q000601:surgery*; D016629:Esophagectomy / Q000009:adverse effects* / Q000379:methods; D004947:Esophagus / Q000601:surgery; D005260:Female; D018662:Fundoplication / Q000379:methods; D005748:Gastric Fundus / Q000503:physiopathology / Q000601:surgery*; D005764:Gastroesophageal Reflux / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D016019:Survival Analysis; D016896:Treatment Outcome