Jerantinines A-G, cytotoxic Aspidosperma alkaloids from Tabernaemontana corymbosa.
Seven new indole alkaloids of the Aspidosperma type, jerantinines A-G (1-7), were isolated from a leaf extract of the Malayan Tabernaemontana corymbosa. The structures were established using NMR and MS analysis. Five of the alkaloids isolated and two derivatives (1-5, 8, 9) displayed pronounced in vitro cytotoxicity against human KB cells (IC50 < 1 microg/mL).
Lim
Kuan-Hon
KH
Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Hiraku
Osamu
O
Komiyama
Kanki
K
Kam
Toh-Seok
TS
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007624:KB Cells; D008296:Malaysia; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D030014:Tabernaemontana / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D026121:Indole Alkaloids