Can genes for mammographic density inform cancer aetiology?
Mammographic density (MD) reflects variations in fat, stromal and epithelial tissues that are thought to be regulated by several genes. High MD is an established risk factor for breast cancer; therefore, genes that regulate MD may indirectly influence breast cancer. These genes might also be fewer in number and easier to identify than those for breast cancer risk outside of inherited predisposition syndromes. In this Perspective, we review the limited genetic studies of MD and propose future directions.
Kelemen
Linda E
LE
Department of Population Health Research, Alberta Cancer Board, 1,331 29th Street North West, Calgary, Alberta T2N 4N2, Canada.
Sellers
Thomas A
TA
Vachon
Celine M
CM
D014408:Biomarkers, Tumor / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D002394:Catechol O-Methyltransferase / Q000235:genetics; D047628:Estrogen Receptor alpha / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics; D008327:Mammography; D011110:Polymorphism, Genetic
D014408:Biomarkers, Tumor; C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; D007334:Insulin-Like Growth Factor I; D002394:Catechol O-Methyltransferase
J Clin Endocrinol Metab. 1992 Oct;75(4):1066-70
1400872
J Clin Invest. 1996 Jun 1;97(11):2569-75
8647950
Lancet Oncol. 2005 Oct;6(10):798-808
16198986
Int J Cancer. 2003 Oct 20;107(1):60-4
12925957
Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1993-7
17035411
Cancer Epidemiol Biomarkers Prev. 2004 Apr;13(4):573-82
15066922
Cancer Epidemiol Biomarkers Prev. 2005 Nov;14(11 Pt 1):2648-54
16284391
Br J Cancer. 2006 Jan 30;94(2):299-307
16404426
Breast Cancer Res Treat. 2005 Nov;94(2):115-22
16261410
AJR Am J Roentgenol. 1987 Jun;148(6):1087-92
3495132
Am J Epidemiol. 1989 Mar;129(3):518-26
2916545
J Clin Endocrinol Metab. 2000 Mar;85(3):1290-5
10720078
J Natl Cancer Inst. 2004 Mar 17;96(6):434-42
15026468
Am J Hum Genet. 1999 May;64(5):1371-7
10205268
J Endocrinol. 2005 Apr;185(1):11-7
15817823
Cancer. 1980 Dec 1;46(11):2433-7
7438019
Cancer Epidemiol Biomarkers Prev. 2005 Nov;14(11 Pt 1):2655-60
16284392
Pharmacogenetics. 1999 Dec;9(6):763-71
10634139
BMC Cancer. 2007 Feb 12;7:30
17295924
Cancer. 1991 Jun 1;67(11):2833-8
2025849
Breast Cancer Res Treat. 2004 Sep;87(2):149-56
15377839
Pharmacogenet Genomics. 2006 Aug;16(8):547-53
16847423
Biochem Biophys Res Commun. 2000 Aug 18;275(1):33-6
10944436
Breast Cancer Res Treat. 2004 Dec;88(3):217-30
15609124
J Clin Endocrinol Metab. 1997 Nov;82(11):3777-82
9360540
J Natl Cancer Inst. 1999 Oct 20;91(20):1778-9
10528030
Cancer Epidemiol Biomarkers Prev. 2007 Jul;16(7):1479-84
17627014
BMC Cancer. 2005 Aug 19;5:107
16111488
Cancer Res. 2006 Feb 1;66(3):1866-72
16452249
Cancer Causes Control. 2006 Aug;17(6):843-50
16783612
Cancer Epidemiol Biomarkers Prev. 2003 Sep;12(9):838-47
14504192
Breast Cancer Res. 2003;5(3):164-73
12793900
AJR Am J Roentgenol. 1997 Jun;168(6):1599-602
9168735
Breast Cancer Res Treat. 2003 Jan;77(1):27-36
12602902
J Clin Endocrinol Metab. 2000 Apr;85(4):1606-10
10770205
Breast Cancer Res. 2005;7(3):R336-44
15987428
Am J Hum Genet. 2004 Jan;74(1):106-20
14681826
J Clin Endocrinol Metab. 1998 Jul;83(7):2286-90
9661596
Mol Cancer Res. 2006 Mar;4(3):135-50
16547151
Biochem J. 1994 Nov 15;304 ( Pt 1):289-93
7998947
Cancer Res. 2001 May 15;61(10):3858-62
11358796
J Natl Cancer Inst. 1995 May 3;87(9):670-5
7752271
Lancet. 1999 Jun 12;353(9169):2070-1
10376643
J Natl Cancer Inst. 2003 Jan 1;95(1):30-7
12509398
Med Phys. 2000 Jan;27(1):4-12
10659732
Breast Cancer Res. 2004;6(4):R437-49
15217512
Mutat Res. 2003 Sep;544(1):9-41
12888106
Atherosclerosis. 2006 Apr;185(2):340-6
16054150
Cancer Res. 2007 Sep 1;67(17):8412-8
17804758
Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):2-19
15668470
Breast Cancer Res. 2002;4(3):R5
12052257
Cancer Epidemiol Biomarkers Prev. 2006 Jan;15(1):172-4
16434607
J Natl Cancer Inst. 2006 Sep 6;98(17):1215-26
16954474
Clin Radiol. 1991 Jun;43(6):385-8
2070577
Pharmacogenetics. 1996 Jun;6(3):243-50
8807664
Cancer Res. 2004 Feb 15;64(4):1237-41
14973115
Breast Cancer Res. 2007;9(1):R18
17300730
J Natl Cancer Inst Monogr. 2000;(27):113-24
10963623
Cancer Epidemiol Biomarkers Prev. 1999 Oct;8(10):843-54
10548311
Nature. 2007 Jun 28;447(7148):1087-93
17529967
Biochem J. 2000 Oct 1;351(Pt 1):67-77
10998348
Nat Genet. 2007 Jul;39(7):870-4
17529973
J Clin Endocrinol Metab. 1998 Jan;83(1):235-40
9435448
Pharmacogenet Genomics. 2006 Apr;16(4):237-43
16538170
Int J Cancer. 2002 Nov 1;102(1):91-5
12353239
AJR Am J Roentgenol. 2002 Jul;179(1):15-20
12076896
Cancer Epidemiol Biomarkers Prev. 2003 Sep;12(9):853-9
14504194
Cancer Epidemiol Biomarkers Prev. 2006 Aug;15(8):1502-8
16896040
Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):1998-2003
16103451
Cancer Epidemiol Biomarkers Prev. 2006 Mar;15(3):449-55
16537700
J Lipid Res. 2006 Jul;47(7):1457-62
16625024
Carcinogenesis. 1999 Aug;20(8):1607-13
10426814
Mutat Res. 2002 Apr 26;516(1-2):41-7
11943609
Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12263-8
12218173
Cancer Res. 1992 Jan 1;52(1):77-83
1345763
J Natl Cancer Inst. 1997 Apr 16;89(8):549-56
9106643
J Clin Endocrinol Metab. 2001 Mar;86(3):1274-80
11238520
AJR Am J Roentgenol. 1978 Jun;130(6):1157-8
418657
Cancer Epidemiol Biomarkers Prev. 2008 Jan;17(1):258-60
18199735
Am J Epidemiol. 1982 Mar;115(3):438-43
7064978
Cancer Epidemiol Biomarkers Prev. 2006 Jun;15(6):1159-69
16775176
Cancer Epidemiol Biomarkers Prev. 2005 Oct;14(10):2316-25
16214911
Br J Radiol. 1987 May;60(713):459-62
3580756
Endocr J. 1999 Apr;46(2):279-84
10460012
Endocrinology. 2003 Aug;144(8):3382-98
12865317
Cancer Res. 1999 Jun 15;59(12):2825-8
10383140
Nat Rev Cancer. 2004 Jul;4(7):505-18
15229476
Nat Genet. 2007 Jul;39(7):865-9
17529974
J Natl Cancer Inst. 2006 Oct 4;98(19):1382-96
17018785
Cancer Epidemiol Biomarkers Prev. 2008 Apr;17(4):880-8
18398029
Am J Epidemiol. 2005 May 15;161(10):901-15
15870154
Carcinogenesis. 2000 Apr;21(4):551-5
10753184
Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):623-5
17372263
J Natl Cancer Inst. 1977 Nov;59(5):1397-400
909098
N Engl J Med. 2002 Sep 19;347(12):886-94
12239257
J Natl Cancer Inst. 1995 Nov 1;87(21):1622-9
7563205
Am J Epidemiol. 2004 Oct 15;160(8):729-40
15466495
AJR Am J Roentgenol. 1976 Jun;126(6):1130-7
179369
Neurosci Lett. 1999 Dec 17;277(1):9-12
10643885
Carcinogenesis. 2000 Feb;21(2):189-93
10657957
J Cell Biochem. 2005 Oct 15;96(3):490-505
16092128
Hum Mol Genet. 2006 Jan 1;15(1):1-10
16306136
Breast Cancer Res Treat. 2008 Nov;112(1):109-22
18064566
N Engl J Med. 2006 Jan 19;354(3):270-82
16421368
Int J Cancer. 2004 Nov 20;112(4):683-8
15382051
J Natl Cancer Inst. 2006 Sep 6;98(17):1204-14
16954473
Diabetes. 2008 Feb;57(2):494-502
17977952
Phys Med Biol. 1994 Oct;39(10):1629-38
15551535
J Natl Cancer Inst. 1992 Aug 5;84(15):1170-9
1635085
Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):612-7
16614099
Cancer Epidemiol Biomarkers Prev. 2006 Mar;15(3):462-7
16537702
J Natl Cancer Inst. 2003 Apr 2;95(7):556-8
12671024
Am J Epidemiol. 2004 Feb 15;159(4):319-35
14769635
Am J Hum Genet. 2003 May;72(5):1117-30
12677558
Cancer Epidemiol Biomarkers Prev. 2008 Jan;17(1):27-32
18199708
Cancer Causes Control. 2005 Dec;16(10):1195-202
16215870