Circular DNA formation on the bimolecular triplex of anthracene-modified oligonucleotide conjugate.
DNA is usually found in nature as a double stranded helix but there are many other structural forms that it can adopt. Triple helical DNA structures are one of these arrangements that DNA can form through some folding interactions. These structures have attracted great interest in the field of DNA recognition due to their higher affinity and selectivity. Here we introduced a bimolecular triplex structure formed by a anthracene-DNA conjugate through a well characterized photodimerization reaction in the presence of complementary target and evaluated the system for the target discrimination by using a mismatch target. Results indicated that the system could provide moderate discrimination.
Arslan
Pelin
P
Department of Applied Chemistry and Biochemistry, Graduate School of Science and Technology, Kumamoto University, Kumamoto 860-8555, Japan.
Ihara
Toshihiro
T
Jyo
Akinori
A
D000873:Anthracenes / Q000737:chemistry* / Q000528:radiation effects; D020029:Base Pairing; D004247:DNA / Q000737:chemistry*; D004270:DNA, Circular / Q000737:chemistry*; D009838:Oligodeoxyribonucleotides / Q000737:chemistry* / Q000528:radiation effects
D000873:Anthracenes; D004270:DNA, Circular; D009838:Oligodeoxyribonucleotides; C051802:triplex DNA; D004247:DNA