Synthesis and antiviral evaluation of conformationally fixed bicyclohexanyl nucleosides with ethenyl group at C3'-position.
Conformationally fixed bicyclo[3.1.0]hexanyl nucleosides 1 and 2 with C3'-ethenyl group were successfully synthesized and evaluated against various viruses. Carbenoid intramolecular cycloaddition and diastereoselective Grignard reaction were employed as the key reaction steps.
Kim
Won Hee
WH
College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan 609-735, Korea.
Kim
Kyung Ran
KR
Park
Ah-Young
AY
Lee
Hyung-Rock
HR
Kang
Jin-Ah
JA
Bae
Jang Ho
JH
Jeong
Lak Shin
LS
Moon
Hyung Ryong
HR
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000998:Antiviral Agents; D001643:Bridged Bicyclo Compounds; D000241:Adenosine