title: Initial experience with ropinirole PR (prolonged release).
abstract: Ropinirole is a non-ergolinic dopamine agonist, which has been used for over 10 years for the treatment of Parkinson's disease. A new formulation (PR = prolonged release) has been developed, which allows the drug to be released slowly (continuously) so that it only has to be given once daily. Switching from the previous ropinirole immediate release ( ropinirole IR) to the prolonged release (ropinirole PR) formulation at the nearest equivalent total daily dose, can take place overnight and the acceptance and tolerability are good. The advantages are once-daily dosing, faster titration with good tolerability and more stable plasma levels. The new formulation is regarded as valuable addition to the currently available medications.
authors.affiliation: Dept. Neurology, Deutsche Klinik für Diagnostik, Germany. jost.neuro@dkd-wiesbaden.de
authors.forename: Wolfgang H
authors.initials: WH
authors.lastname: Jost
authors.forename: Carsten
authors.initials: C
authors.lastname: Buhmann
authors.forename: Gerd
authors.initials: G
authors.lastname: Fuchs
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Greulich
authors.forename: Sibylla
authors.initials: S
authors.lastname: Hummel
authors.forename: Alexei
authors.initials: A
authors.lastname: Korchounov
authors.forename: Martina
authors.initials: M
authors.lastname: Müngersdorf
authors.forename: Michael
authors.initials: M
authors.lastname: Schwarz
authors.forename: Mechthild
authors.initials: M
authors.lastname: Spiegel-Meixensberger
mesh_terms: D000978:Antiparkinson Agents / Q000008:administration & dosage*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004334:Drug Administration Schedule; D006801:Humans; D007211:Indoles / Q000008:administration & dosage*; D010300:Parkinson Disease / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D000978:Antiparkinson Agents; D007211:Indoles; C046649:ropinirole
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