title: Evolutionary medicine: update on the relevance to family practice.
abstract: OBJECTIVE
  To review the relevance of evolutionary medicine to family practice and family physician training.
  
  
  METHODS
  Articles were located through a MEDLINE search, using the key words evolution, Darwin, and adaptation. Most references presented level III evidence (expert opinion), while a minority provided level II evidence (epidemiologic studies).
  
  
  RESULTS
  Evolutionary medicine deals with the interplay of biology and the environment in the understanding of human disease. Yet medical schools have virtually ignored the need for family physicians to have more than a cursory knowledge of this topic. A review of the main trends in this field most relevant to family practice revealed that a basic knowledge of evolutionary medicine might help in explaining the causation of diseases to patients. Evolutionary medicine has also proven key to explaining the reasons for the development of antibiotic resistance and has the potential to explain cancer pathogenesis. As an organizing principle, this field also has potential in the teaching of family medicine.
  
  
  CONCLUSIONS
  Evolutionary medicine should be studied further and incorporated into medical training and practice. Its practical utility will be proven through the generation of testable hypotheses and their application in relation to disease causation and possible prevention.
authors.affiliation: Department of Pathology and Laboratory Medicine, Dalhousie University, 5788 University Ave, Halifax, NS B3H 2Y9. nauglerc@dal.ca
authors.forename: Christopher T
authors.initials: CT
authors.lastname: Naugler
mesh_terms: D000220:Adaptation, Biological; D005075:Biological Evolution; D004501:Education, Medical / Q000379:methods; D005194:Family Practice / Q000193:education*; D006801:Humans; D008954:Models, Biological; D017145:Models, Educational
references.citation: Philos Ethics Humanit Med. 2007 Apr 03;2:4
references.pmid: 17407602
references.citation: N Engl J Med. 1985 Jan 31;312(5):283-9
references.pmid: 2981409
references.citation: Lancet Oncol. 2002 Apr;3(4):244-51
references.pmid: 12067687
references.citation: Perspect Biol Med. 1998 Autumn;42(1):44-74
references.pmid: 9894356
references.citation: Am J Hum Genet. 1962 Dec;14:353-62
references.pmid: 13937884
references.citation: J R Soc Med. 1997 Jul;90(7):397-9
references.pmid: 9290423
references.citation: Q Rev Biol. 2001 Dec;76(4):417-32
references.pmid: 11783396
references.citation: Vaccine. 2000 Feb 25;18(16):1567-83
references.pmid: 10689131
references.citation: Psychopathology. 2008;41(1):17-27
references.pmid: 17952017
references.citation: Trends Immunol. 2001 Dec;22(12):665-9
references.pmid: 11738996
references.citation: Ann Hum Genet. 1975 May;38(4):461-9
references.pmid: 1190737
references.citation: Q Rev Biol. 1994 Sep;69(3):353-67
references.pmid: 7972680
references.citation: Med Hypotheses. 2008;70(3):691-2
references.pmid: 17689879
references.citation: Clin Microbiol Infect. 2007 Mar;13(3):222-35
references.pmid: 17391376
references.citation: Exp Gerontol. 2003 Jan-Feb;38(1-2):13-25
references.pmid: 12543257
references.citation: Science. 1997 Oct 3;278(5335):63-6
references.pmid: 9311928
references.citation: Arch Gen Psychiatry. 2000 Jan;57(1):14-20
references.pmid: 10632228
references.citation: Curr Biol. 2007 May 1;17(9):783-8
references.pmid: 17442572
references.citation: Curr Opin Microbiol. 2006 Aug;9(4):388-94
references.pmid: 16815736
references.citation: Pediatr Infect Dis J. 2006 Oct;25(10):977-80
references.pmid: 17006310
references.citation: Proc Natl Acad Sci U S A. 1981 Nov;78(11):6858-62
references.pmid: 6947260
references.citation: J Fam Pract. 2006 Apr;55(4):320-5
references.pmid: 16608671
references.citation: Prev Med. 2005 Jun;40(6):904-9
references.pmid: 15850894
references.citation: CMAJ. 2007 Oct 9;177(8):877-83
references.pmid: 17923655
references.citation: Prev Med. 2002 Feb;34(2):109-18
references.pmid: 11817903
references.citation: J Infect Dis. 2005 Jul 1;192(1):178-86
references.pmid: 15942909
references.citation: Med Educ. 2006 May;40(5):471-2
references.pmid: 16635141
references.citation: Nature. 1987 Sep 24-30;329(6137):289-90
references.pmid: 3114647
references.citation: Blood. 2004 Nov 15;104(10):3364-71
references.pmid: 15280204
references.citation: Psychosom Med. 1998 Jul-Aug;60(4):510-20
references.pmid: 9710299
references.citation: Prog Neuropsychopharmacol Biol Psychiatry. 2006 Jul;30(5):766-73
references.pmid: 16580111
references.citation: Med Hypotheses. 2002 Sep;59(3):325-9
references.pmid: 12208162