title: Wiring and firing neuronal networks: endocannabinoids take center stage.
abstract: Endocannabinoids (eCBs) function as retrograde messengers at both excitatory and inhibitory synapses, and control various forms of synaptic plasticity in the adult brain. The molecular machinery required for specific eCB functions during synaptic plasticity is well established. However, eCB signaling plays surprisingly fundamental roles in controlling the acquisition of neuronal identity during CNS development. Recent work suggests that selective recruitment of regulatory signaling networks to CB1 cannabinoid receptors dictates neuronal state-change decisions. In addition, the spatial localization and temporal precision of eCB actions emerges as a novel organizer in developing neuronal networks. Current challenges include fitting novel molecular candidates into regulatory eCB signaling pathways, and defining the temporal dynamics of context-dependent signaling mechanisms underpinning particular neuronal specification events.
authors.affiliation: Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1 :A1, Karolinska Institute, SE-17177 Stockholm, Sweden. Tibor.Harkany@ki.se
authors.forename: Tibor
authors.initials: T
authors.lastname: Harkany
authors.forename: Ken
authors.initials: K
authors.lastname: Mackie
authors.forename: Patrick
authors.initials: P
authors.lastname: Doherty
mesh_terms: D000818:Animals; D063385:Cannabinoid Receptor Modulators / Q000378:metabolism*; D063388:Endocannabinoids; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D043884:Receptor, Cannabinoid, CB1 / Q000502:physiology; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D063385:Cannabinoid Receptor Modulators; D063388:Endocannabinoids; D043884:Receptor, Cannabinoid, CB1
references.citation: Mol Cell Neurosci. 1996 Aug;8(2/3):120-8
references.pmid: 8954627
references.citation: J Cell Sci. 2008 May 15;121(Pt 10):1704-1717
references.pmid: 18445684
references.citation: Nature. 1996 Nov 7;384(6604):83-7
references.pmid: 8900284
references.citation: J Biol Chem. 2006 Apr 28;281(17):11910-6
references.pmid: 16501258
references.citation: Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9388-93
references.pmid: 15964987
references.citation: EMBO J. 2001 Nov 1;20(21):5887-97
references.pmid: 11689429
references.citation: Br J Pharmacol. 2006 Jun;148(4):387-95
references.pmid: 16682964
references.citation: J Cell Biol. 2006 Jul 3;174(1):127-39
references.pmid: 16818724
references.citation: Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2699-704
references.pmid: 18263732
references.citation: J Neurosci. 2006 May 24;26(21):5794-9
references.pmid: 16723537
references.citation: Cereb Cortex. 2006 Jul;16 Suppl 1:i3-17
references.pmid: 16766705
references.citation: Development. 2003 Apr;130(8):1479-91
references.pmid: 12620975
references.citation: J Neurosci. 2006 May 31;26(22):5901-9
references.pmid: 16738232
references.citation: Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19115-20
references.pmid: 16357196
references.citation: J Neurosci. 2004 May 26;24(21):4978-88
references.pmid: 15163690
references.citation: J Cell Biol. 2003 Feb 17;160(4):481-6
references.pmid: 12578907
references.citation: J Biol Chem. 2008 Apr 4;283(14):9341-9
references.pmid: 18227059
references.citation: J Neurosci. 2006 Feb 1;26(5):1551-61
references.pmid: 16452678
references.citation: Science. 2007 May 25;316(5828):1212-6
references.pmid: 17525344
references.citation: J Cell Biol. 2003 Nov 10;163(3):463-8
references.pmid: 14610053
references.citation: Neuropsychopharmacology. 2007 Nov;32(11):2249-59
references.pmid: 17356572
references.citation: Mol Pharmacol. 2005 May;67(5):1697-704
references.pmid: 15710746
references.citation: J Neurosci. 2001 May 15;21(10):RC146
references.pmid: 11319244
references.citation: Mol Cell Neurosci. 2008 Aug;38(4):526-36
references.pmid: 18562209
references.citation: Trends Neurosci. 2000 Jan;23(1):14-20
references.pmid: 10631784
references.citation: J Neurosci. 2007 Apr 4;27(14):3663-76
references.pmid: 17409230
references.citation: J Anat. 2004 Sep;205(3):213-8
references.pmid: 15379926
references.citation: J Neurosci. 2001 Dec 15;21(24):9770-81
references.pmid: 11739585
references.citation: J Clin Invest. 2005 Nov;115(11):3104-16
references.pmid: 16224541
references.citation: Br J Pharmacol. 2007 Dec;152(7):1092-101
references.pmid: 17876302
references.citation: Biochem Biophys Res Commun. 2007 Nov 3;362(4):928-34
references.pmid: 17765871
references.citation: Proc Natl Acad Sci U S A. 2008 Jun 24;105(25):8760-5
references.pmid: 18562289
references.citation: Mol Pharmacol. 2004 Aug;66(2):204-8
references.pmid: 15266010
references.citation: Science. 2008 May 16;320(5878):903-9
references.pmid: 18487186
references.citation: Neurosci Biobehav Rev. 2006;30(1):24-41
references.pmid: 16095697
references.citation: Nat Rev Neurosci. 2003 Nov;4(11):873-84
references.pmid: 14595399
references.citation: Nat Neurosci. 2005 Feb;8(2):164-72
references.pmid: 15665879
references.citation: Neurosci Res. 2008 Jun;61(2):192-200
references.pmid: 18395922
references.citation: Nature. 2001 Mar 29;410(6828):588-92
references.pmid: 11279497
references.citation: Nature. 2004 Sep 16;431(7006):312-6
references.pmid: 15372034
references.citation: J Physiol. 2007 Feb 1;578(Pt 3):773-85
references.pmid: 17110416
references.citation: Annu Rev Neurosci. 2006;29:37-76
references.pmid: 16776579
references.citation: J Neurosci. 2006 Dec 27;26(52):13531-6
references.pmid: 17192436
references.citation: Mol Cell Neurosci. 2008 May;38(1):89-97
references.pmid: 18378465
references.citation: Chem Phys Lipids. 2002 Dec 31;121(1-2):149-58
references.pmid: 12505697
references.citation: J Neurosci. 2006 May 3;26(18):4740-51
references.pmid: 16672646
references.citation: Prostaglandins Other Lipid Mediat. 2005 Sep;77(1-4):111-22
references.pmid: 16099396
references.citation: Nat Neurosci. 2008 Feb;11(2):152-9
references.pmid: 18204441
references.citation: Prog Neurobiol. 2002 Nov;68(4):247-86
references.pmid: 12498988
references.citation: Mol Pharmacol. 2007 Apr;71(4):976-84
references.pmid: 17182888