Pathological findings of multifocal choroiditis with panuveitis and punctate inner choroidopathy.
OBJECTIVE
To compare the pathological findings between multifocal choroiditis with panuveitis (MCP) and punctate inner choroidopathy (PIC).


METHODS
Fourteen eyes of 14 patients clinically diagnosed as having MCP or PIC who underwent surgical excision of choroidal neovascularization (CNV) were studied. Immunohistochemical findings of the excised CNV in MCP (eight eyes) and PIC (six eyes) cases were compared. Antibodies against vascular endothelial growth factor (VEGF), CD68, CD3, and CD20 were used as primary antibodies.


RESULTS
Expression of VEGF and CD68 in the CNV was observed in all MCF and PIC cases. In three of eight eyes with MCP, intraocular inflammatory findings were found clinically, while immunohistochemical study demonstrated infiltration of CD20-positive B lymphocytes in the CNV. No B lymphocyte infiltration was found in the six eyes with PIC. No differences in pathological findings were found between the five MCP eyes without intraocular inflammation and the six PIC eyes, with all eyes showing no B lymphocyte infiltration.


CONCLUSIONS
In MPC cases showing clinical inflammatory findings, infiltration of B lymphocytes was also observed histopathologically, suggesting that the presence of inflammatory cells in the anterior chamber or vitreous body clinically is an indicator of active inflammatory CNV. However, this study clarifies that MCP eyes without intraocular inflammation and PIC eyes are not different in histopathological findings.
Shimada
Hiroyuki
H
Department of Ophthalmology, School of Medicine, Nihon University, Tokyo, Japan. sshimada@olive.ocn.ne.jp.
Yuzawa
Mitsuko
M
Department of Ophthalmology, School of Medicine, Nihon University, Tokyo, Japan.
Hirose
Tokihito
T
Department of Ophthalmology, School of Medicine, Nihon University, Tokyo, Japan.
Nakashizuka
Hiroyuki
H
Department of Ophthalmology, School of Medicine, Nihon University, Tokyo, Japan.
Hattori
Takayuki
T
Department of Ophthalmology, School of Medicine, Nihon University, Tokyo, Japan.
Kazato
Yoko
Y
Department of Ophthalmology, School of Medicine, Nihon University, Tokyo, Japan.
D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D020256:Choroidal Neovascularization / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D002833:Choroiditis / Q000473:pathology*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D015864:Panuveitis / Q000473:pathology*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D015703:Antigens, CD; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A
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