Molecular characterization of a variant of Bacillus anthracis-specific phage AP50 with improved bacteriolytic activity.
The genome sequence of a Bacillus anthracis-specific clear plaque mutant phage, AP50c, contains 31 open reading frames spanning 14,398 bp, has two mutations compared to wild-type AP50t, and has a colinear genome architecture highly similar to that of gram-positive Tectiviridae phages. Spontaneous AP50c-resistant B. anthracis mutants exhibit a mucoid colony phenotype.
Sozhamannan
Shanmuga
S
Naval Medical Research Center, Silver Spring, Maryland 20910, USA. Shanmuga.Sozhamannan@med.navy.mil
McKinstry
Michael
M
Lentz
Shannon M
SM
Jalasvuori
Matti
M
McAfee
Farrell
F
Smith
Angela
A
Dabbs
Jason
J
Ackermann
Hans-W
HW
Bamford
Jaana K H
JK
Mateczun
Alfred
A
Read
Timothy D
TD
D017103:Bacillus Phages / Q000235:genetics*; D001408:Bacillus anthracis / Q000821:virology*; D001433:Bacteriolysis; D001483:Base Sequence; D004279:DNA, Viral / Q000235:genetics*; D023061:Gene Order; D016679:Genome, Viral; D008969:Molecular Sequence Data; D020125:Mutation, Missense; D017354:Point Mutation; D017422:Sequence Analysis, DNA; D026801:Synteny; D017916:Tectiviridae / Q000235:genetics; D010948:Viral Plaque Assay; D014771:Virion / Q000648:ultrastructure
D004279:DNA, Viral
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