title: A new linker group for functionalization of nucleic acids.
abstract: A new linker bearing two orthogonal precursor groups - an amino group for the reaction with electrophilic agents, and also a terminal triple bond for the reaction with an aliphatic azido group (1,3-dipolar cycloaddition reaction) for the introduction of the different residues into nucleosides is designed and synthesized. 5'-Triphosphates of various nucleosides bearing proposed linker group have been obtained.
authors.affiliation: Institute of Chemical Biology & Fundamental Medicine, Lavrentev Ave, 8, Novosibirsk, 630090 Russia. Vasilieva_2001@mail.ru
authors.forename: Svetlana
authors.initials: S
authors.lastname: Vasileva
authors.forename: Dmitrii
authors.initials: D
authors.lastname: Konevetz
authors.forename: Boris
authors.initials: B
authors.lastname: Budilkin
authors.forename: Tatiana
authors.initials: T
authors.lastname: Abramova
authors.forename: Nina
authors.initials: N
authors.lastname: Kasatkina
authors.forename: Vladimir
authors.initials: V
authors.lastname: Silnikov
mesh_terms: D000081:Acetamides / Q000138:chemical synthesis / Q000737:chemistry; D003845:Deoxycytosine Nucleotides / Q000737:chemistry; D003853:Deoxyribonucleosides / Q000737:chemistry*; D003854:Deoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry; D015224:Dideoxynucleosides / Q000737:chemistry; D004987:Ethers / Q000138:chemical synthesis / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010797:Phthalimides / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000081:Acetamides; D003845:Deoxycytosine Nucleotides; D003853:Deoxyribonucleosides; D003854:Deoxyribonucleotides; D015224:Dideoxynucleosides; D004987:Ethers; C541626:N-3-phthalimidopropyl progargyl ether; D010797:Phthalimides; C541627:propynyloxypropyl trifluoroacetamide; C024107:2'-deoxycytidine 5'-triphosphate