title: Novel biomarkers for predicting preeclampsia.
abstract: Preeclampsia is a major cause of maternal morbidity and mortality worldwide. Despite decades of research into the condition, the ability of clinicians to predict preeclampsia prior to the onset of symptoms has not improved significantly. In this review, we will examine the pathophysiology underlying preeclampsia and will look at potential biomarkers for early prediction and diagnosis. In addition, we will explore potential future areas of research into the condition.
authors.affiliation: BHF Glasgow Cardiovascular Research Centre, University of Glasgow, G12 8TA Glasgow, United Kingdom.
authors.forename: David M
authors.initials: DM
authors.lastname: Carty
authors.forename: Christian
authors.initials: C
authors.lastname: Delles
authors.forename: Anna F
authors.initials: AF
authors.lastname: Dominiczak
mesh_terms: D028341:Activins / Q000378:metabolism; D043925:Angiogenesis Inducing Agents / Q000378:metabolism; D015703:Antigens, CD / Q000378:metabolism; D001057:Apolipoproteins E / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism*; D000071063:Endoglin; D005260:Female; D006801:Humans; D007265:Inhibins / Q000378:metabolism; D007333:Insulin Resistance; D011225:Pre-Eclampsia / Q000175:diagnosis* / Q000503:physiopathology; D011247:Pregnancy; D011266:Pregnancy-Associated Plasma Protein-A / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000378:metabolism
chemical_list: D043925:Angiogenesis Inducing Agents; D015703:Antigens, CD; D001057:Apolipoproteins E; D015415:Biomarkers; C064206:ENG protein, human; D000071063:Endoglin; D011956:Receptors, Cell Surface; C422405:activin A; C422362:inhibin A; D028341:Activins; D007265:Inhibins; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1; C430889:PAPPA2 protein, human; D011266:Pregnancy-Associated Plasma Protein-A
references.citation: Am J Obstet Gynecol. 2005 Jul;193(1):16-22
references.pmid: 16021053
references.citation: J Clin Pathol. 1998 Apr;51(4):324-5
references.pmid: 9659248
references.citation: Placenta. 2003 Apr;24 Suppl A:S21-7
references.pmid: 12842410
references.citation: J Korean Med Sci. 2006 Jun;21(3):452-6
references.pmid: 16778388
references.citation: Cochrane Database Syst Rev. 2006 Jul 19;(3):CD001059
references.pmid: 16855957
references.citation: BJOG. 2006 Nov;113(11):1264-9
references.pmid: 17010118
references.citation: J Rheumatol. 2008 Apr;35(4):631-4
references.pmid: 18278839
references.citation: Lancet. 1997 May 3;349(9061):1285-8
references.pmid: 9142063
references.citation: Hypertension. 2007 Jul;50(1):137-42
references.pmid: 17515455
references.citation: Nephrol Dial Transplant. 2006 Nov;21(11):3052-4
references.pmid: 16870672
references.citation: Acta Obstet Gynecol Scand. 2004 Jan;83(1):117
references.pmid: 14758802
references.citation: J Korean Med Sci. 2007 Oct;22(5):873-7
references.pmid: 17982238
references.citation: Fertil Steril. 2008 Jan;89(1):174-8
references.pmid: 17509577
references.citation: FEBS Lett. 2001 Aug 24;504(1-2):36-40
references.pmid: 11522292
references.citation: Eur J Obstet Gynecol Reprod Biol. 2004 Jan 15;112(1):9-15
references.pmid: 14687732
references.citation: J Clin Endocrinol Metab. 2002 Apr;87(4):1563-8
references.pmid: 11932283
references.citation: Electrophoresis. 2007 May;28(9):1407-17
references.pmid: 17427258
references.citation: J Clin Endocrinol Metab. 2003 May;88(5):2348-51
references.pmid: 12727995
references.citation: Placenta. 2004 Aug;25(7):608-22
references.pmid: 15193867
references.citation: Acta Obstet Gynecol Scand. 2002 Jun;81(6):540-3
references.pmid: 12047308
references.citation: Hum Reprod. 2000 Jul;15(7):1640-5
references.pmid: 10875882
references.citation: Obstet Gynecol. 2002 Jul;100(1):140-4
references.pmid: 12100816
references.citation: J Clin Endocrinol Metab. 2007 Jul;92(7):2672-9
references.pmid: 17426083
references.citation: Nat Med. 2006 Jun;12(6):642-9
references.pmid: 16751767
references.citation: Am J Obstet Gynecol. 2004 Jun;190(6):1541-7; discussion 1547-50
references.pmid: 15284729
references.citation: Eur J Obstet Gynecol Reprod Biol. 2005 Sep 1;122(1):33-9
references.pmid: 15935542
references.citation: Eur J Endocrinol. 2008 Feb;158(2):197-201
references.pmid: 18230826
references.citation: Nat Med. 2002 Dec;8(12):1439-44
references.pmid: 12447357
references.citation: Analyst. 2003 Jan;128(1):32-6
references.pmid: 12572799
references.citation: Metabolism. 1998 Jan;47(1):70-4
references.pmid: 9440480
references.citation: Obstet Gynecol. 2004 Dec;104(6):1367-91
references.pmid: 15572504
references.citation: Ultrasound Obstet Gynecol. 2006 Jan;27(1):13-7
references.pmid: 16374755
references.citation: Am J Obstet Gynecol. 1999 Jul;181(1):131-6
references.pmid: 10411808
references.citation: Clin Endocrinol (Oxf). 2006 Apr;64(4):469-73
references.pmid: 16584522
references.citation: Am J Obstet Gynecol. 2007 Jul;197(1):35.e1-7
references.pmid: 17618748
references.citation: Prenat Diagn. 2008 Jan;28(1):7-10
references.pmid: 18000943
references.citation: Cochrane Database Syst Rev. 2004;(1):CD004659
references.pmid: 14974075
references.citation: Kidney Int. 2006 Nov;70(10):1847-57
references.pmid: 17021608
references.citation: Lancet. 2006 Apr 8;367(9517):1145-54
references.pmid: 16616557
references.citation: Lancet. 2002 Jul 6;360(9326):57-8
references.pmid: 12114044
references.citation: J Clin Endocrinol Metab. 2004 Feb;89(2):770-5
references.pmid: 14764795
references.citation: Baillieres Best Pract Res Clin Obstet Gynaecol. 2000 Dec;14(6):969-80
references.pmid: 11141344
references.citation: Am J Transplant. 2005 Oct;5(10):2479-88
references.pmid: 16162198
references.citation: BJOG. 2003 Jan;110(1):46-52
references.pmid: 12504935
references.citation: J Neurochem. 2002 Aug;82(4):809-18
references.pmid: 12358786
references.citation: Hypertension. 2003 Nov;42(5):891-4
references.pmid: 14517227
references.citation: Nature. 2007 Jun 7;447(7145):661-78
references.pmid: 17554300
references.citation: Clin Chim Acta. 2007 Jan;375(1-2):49-56
references.pmid: 16942764
references.citation: Am J Clin Nutr. 2000 May;71(5 Suppl):1256S-61S
references.pmid: 10799399
references.citation: Ultrasound Obstet Gynecol. 2003 Feb;21(2):165-9
references.pmid: 12601840
references.citation: Am J Hum Genet. 2005 Jul;77(1):127-31
references.pmid: 15889386
references.citation: Health Technol Assess. 2008 Mar;12(6):iii-iv, 1-270
references.pmid: 18331705
references.citation: Hypertens Pregnancy. 2003;22(1):45-55
references.pmid: 12648442
references.citation: J Korean Med Sci. 2007 Feb;22(1):94-8
references.pmid: 17297258
references.citation: J Clin Pathol. 2001 Aug;54(8):652-4
references.pmid: 11477126
references.citation: Am J Obstet Gynecol. 2006 Feb;194(2):551-6
references.pmid: 16458660
references.citation: Hypertens Pregnancy. 2002;21(2):127-33
references.pmid: 12175441
references.citation: Hypertens Pregnancy. 2005;24(3):303-11
references.pmid: 16263602
references.citation: Br Med J. 1980 Mar 8;280(6215):671-3
references.pmid: 6153917
references.citation: Mol Cell Proteomics. 2008 Feb;7(2):290-8
references.pmid: 17951555
references.citation: Prenat Diagn. 2002 Sep;22(9):778-82
references.pmid: 12224070
references.citation: N Engl J Med. 2006 Sep 7;355(10):992-1005
references.pmid: 16957146
references.citation: J Am Soc Nephrol. 2004 Sep;15(9):2440-8
references.pmid: 15339993
references.citation: Hum Reprod Update. 2005 Mar-Apr;11(2):123-35
references.pmid: 15618291
references.citation: J Clin Invest. 2003 Mar;111(5):649-58
references.pmid: 12618519
references.citation: Obstet Gynecol. 1997 Mar;89(3):403-8
references.pmid: 9052594
references.citation: Br J Obstet Gynaecol. 1996 Dec;103(12):1191-6
references.pmid: 8968234
references.citation: J Clin Endocrinol Metab. 2002 Apr;87(4):1762-7
references.pmid: 11932314
references.citation: Nature. 2007 Jun 7;447(7145):655-60
references.pmid: 17554299
references.citation: Am J Obstet Gynecol. 2007 Jul;197(1):28.e1-6
references.pmid: 17618745
references.citation: Nephrol Dial Transplant. 2007 Oct;22(10):2778-80
references.pmid: 17616538
references.citation: Eur Urol. 2005 Nov;48(5):865-71
references.pmid: 15964125
references.citation: BJOG. 2000 Oct;107(10):1265-70
references.pmid: 11028579
references.citation: Acta Obstet Gynecol Scand. 2005 Feb;84(2):117-21
references.pmid: 15683369
references.citation: Mol Cell Proteomics. 2002 Oct;1(10):763-80
references.pmid: 12438560
references.citation: Acta Obstet Gynecol Scand. 2007;86(8):930-7
references.pmid: 17653877