Relationship between hypomagnesemia and glucose homeostasis.
BACKGROUND
Controversial data are available on the relationship between magnesium metabolism and glucose homeostasis.


METHODS
We performed a retrospective analysis to retrieve results of serum magnesium and fasting plasma glucose (FPG) tests (7,659 outpatients >35 years old).


RESULTS
Subjects with FPG value > 7.0 mmol/L were more likely to had hypomagnesemia. The frequency of hypomagnesemia was also significantly higher among those with high FPG values > 7.0 mmol/L. In multivariable linear regression analysis, magnesium was significantly associated with FPG only in patients with FPG > 7.0 mmol/L.


CONCLUSIONS
Magnesium metabolism could be implicated in the glucose homeostasis, especially in patients with FPG values suggestive for diabetes.
Montagnana
Martina
M
Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico-Biomediche, Università di Verona, Italy. martina.montagnana@med.lu.se
Lippi
Giuseppe
G
Targher
Giovanni
G
Salvagno
Gian Luca
GL
Guidi
Gian Cesare
GC
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000097:blood*; D005260:Female; D006801:Humans; D008274:Magnesium / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
D001786:Blood Glucose; D008274:Magnesium