Physicochemical stability of NOX-E36, a 40mer L-RNA (Spiegelmer) for therapeutic applications.
Spiegelmers are structured mirror-image oligonucleotides that are designed to bind and inhibit pharmacologically relevant target molecules. The synthesis and purification of mirror-image oligonucleotides is comparable to the manufacturing of standard oligonucleotides that consist of naturally configured nucleotides. Due to the use of the non-natural L-nucleotides in Spiegelmers, these oligonucleotides show an exceptional biostability. Further, they also display a high physicochemical stability in solution. These properties make them interesting substances for drug development.
Maasch
Christian
C
NOXXON Pharma AG, Max-Dohrn-Strasse 8-10, D-10589 Berlin, Germany.
Buchner
Klaus
K
Eulberg
Dirk
D
Vonhoff
Stefan
S
Klussmann
Sven
S
D052157:Aptamers, Nucleotide / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D002460:Cell Line; D018932:Chemokine CCL2 / Q000037:antagonists & inhibitors*; D002633:Chemotaxis / Q000187:drug effects; D006801:Humans; D007249:Inflammation / Q000188:drug therapy
D052157:Aptamers, Nucleotide; C111835:CCL2 protein, human; D018932:Chemokine CCL2; C541611:NOX-E36 aptamer