title: [Natural course of the arteriovenous malformations of the brain].
abstract: Arteriovenous cerebral malformations represent congenital malformations. Considering the anatomical characteristics of the cerebral angiomas and their localization, in a great number of cases they demand a combined therapeutic approach--surgery, embolization and radiotherapy. Besides the constant progress of technology, 5% of all cerebral angiomas can not be completely excluded from the circulation. Therefore, the need to understand their natural course became a necessity. Our results point to the fact that they are vascular malformations of a considerably more benign clinical course than the aneurysms. Our clinical model points to an annual risk of hemorrhage which is 3.3% with total mortality of 5.3%, especially if the size of the angioma is 2.5-5 cm, localized in the motor zone of the brain, with combined type of vein drainage and arterial supply from the vertebrobasilary confluence. Epilepsy caused by the cerebral angioma is in 26.7% refractory to medicamentous therapy and in 25% (every 4th patient) will have hemorrhage with an annual risk of 0.14%.
authors.affiliation: Institut za neurohirurgiju KCS, Beograd.
authors.forename: G M
authors.initials: GM
authors.lastname: Tasić
authors.forename: A
authors.initials: A
authors.lastname: Kostić
authors.forename: B M
authors.initials: BM
authors.lastname: Djurović
authors.forename: V T
authors.initials: VT
authors.lastname: Jovanović
authors.forename: I M
authors.initials: IM
authors.lastname: Nikolić
authors.forename: A M
authors.initials: AM
authors.lastname: Erić
authors.forename: M B
authors.initials: MB
authors.lastname: Joković
authors.forename: M V
authors.initials: MV
authors.lastname: Mićović
mesh_terms: D000293:Adolescent; D000328:Adult; D002543:Cerebral Hemorrhage / Q000209:etiology; D002648:Child; D005260:Female; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000145:classification / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged