title: Recent developments in microwave-assisted protein chemistries - can this be integrated into the drug discovery and validation process?
abstract: Over the past 30 years, biotechnology has evolved as a multibillion dollar industry. A large sector of this industry is associated with translating human genetic information to discover, develop and commercialize bio-therapeutics. A broad range of disciplines across the Life Sciences is necessary for the selection of bio-molecules as biotechnological drug targets. Global and targeted proteomic approaches, as well as in-depth characterization of select proteins, are part of the process necessary for drug discovery and validation. Recently, microwave-assisted proteomic methodologies have emerged as useful tools for increasing the bio-catalysis and, therefore, throughput of analytical processes associated with protein characterization. Several microwave-assisted protocols that have become integrated into the drug discovery research process in the biotechnology industry are discussed.
authors.affiliation: Genentech Inc., Department of Protein Chemistry, 1 DNA Way, MS 413A, South San Francisco, CA 94080, USA.
authors.forename: Wendy N
authors.initials: WN
authors.lastname: Sandoval
authors.forename: Victoria C
authors.initials: VC
authors.lastname: Pham
authors.forename: Jennie R
authors.initials: JR
authors.lastname: Lill
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D001709:Biotechnology / Q000379:methods; D055808:Drug Discovery / Q000379:methods*; D008872:Microwaves; D011506:Proteins / Q000737:chemistry / Q000378:metabolism; D040901:Proteomics / Q000379:methods*; D020539:Sequence Analysis, Protein / Q000379:methods
chemical_list: D000596:Amino Acids; D011506:Proteins