Mediastinal seminoma in a patient with multiple endocrine neoplasia type 1.
A patient with multiple endocrine neoplasia type 1 (MEN1) developed a mediastinal seminoma. The patient was a 46-year-old man who presented with respiratory symptoms. A diagnosis of mediastinal seminoma was pathologically confirmed and a complete remission was achieved by chemotherapy. During his hospital stay, hyperparathyroidism and multiple pancreatic tumors associated with hypergastrinemia were found. A diagnosis of MEN1 was made genetically. Although patients with MEN1 manifest a variety of neoplastic disorders, no cases of concurrent seminoma and MEN1 have previously been reported. In addition, no etiological relationship between seminoma and MEN1 has yet been reported.
Tanabe
Tsuyoshi
T
The First Department of Internal Medicine, Shinshu University School of Medicine, and Shinhu University Hospital, Matsumoto. tanatuyo@shinshu-u.ac.jp
Yasuo
Masanori
M
Tsushima
Kenji
K
Urushihata
Kazuhisa
K
Yamamoto
Hiroshi
H
Hanaoka
Masayuki
M
Koizumi
Tomonobu
T
Fujimoto
Keisaku
K
Yamazaki
Yoshitaka
Y
Hirose
Yoshiki
Y
Hamano
Hideaki
H
Sakurai
Akihiro
A
Kubo
Keishi
K
D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D008875:Middle Aged; D018761:Multiple Endocrine Neoplasia Type 1 / Q000175:diagnosis*; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000188:drug therapy; D012074:Remission Induction; D018239:Seminoma / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology