title: Evidence for the co-circulation of dengue virus type 3 genotypes III and V in the Northern region of Brazil during the 2002-2004 epidemics.
abstract: The reintroduction of dengue virus type 3 (DENV-3) in Brazil in 2000 and its subsequent spread throughout the country was associated with genotype III viruses, the only DENV-3 genotype isolated in Brazil prior to 2002. We report here the co-circulation of two different DENV-3 genotypes in patients living in the Northern region of Brazil during the 2002-2004 epidemics. Complete genomic sequences of viral RNA were determined from these epidemics, and viruses belonging to genotypes V (Southeast Asia/South Pacific) and III were identified. This recent co-circulation of different DENV-3 genotypes in South America may have implications for pathological and epidemiological dynamics.
authors.affiliation: Instituto Carlos Chagas, Curitiba, PR, Brasil.
authors.forename: Meri Bordignon
authors.initials: MB
authors.lastname: Nogueira
authors.forename: Vanessa
authors.initials: V
authors.lastname: Stella
authors.forename: Juliano
authors.initials: J
authors.lastname: Bordignon
authors.forename: Weber Cheli
authors.initials: WC
authors.lastname: Batista
authors.forename: Luana de
authors.initials: Ld
authors.lastname: Borba
authors.forename: Luis Hildebrando Pereira da
authors.initials: LH
authors.lastname: Silva
authors.forename: Federico Guillermo
authors.initials: FG
authors.lastname: Hoffmann
authors.forename: Christian Macagnan
authors.initials: CM
authors.lastname: Probst
authors.forename: Claudia Nunes Duarte dos
authors.initials: CN
authors.lastname: Santos
mesh_terms: D001938:Brazil / Q000453:epidemiology; D003715:Dengue / Q000453:epidemiology / Q000821:virology*; D003716:Dengue Virus / Q000145:classification / Q000235:genetics*; D004196:Disease Outbreaks; D005838:Genotype; D006801:Humans; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D012367:RNA, Viral