title: Reference values for alpha1-acid glycoprotein, alpha1-antitrypsin, albumin, haptoglobin, C-reactive protein, IgA, IgG and IgM during pregnancy.
abstract: The objective of this study was to establish reference intervals and decision limits for the interpretation of the acute phase proteins alpha(1)-acid glycoprotein (orosomucoid), alpha(1)-antitrypsin, C-reactive protein (CRP), haptoglobin and albumin, IgA, IgG and IgM during pregnancy by longitudinal sampling from 52 healthy women with normal pregnancies. Each woman was sampled in weeks 7-17; weeks 17-24; weeks 24-28; weeks 28-31; weeks 31-34; weeks 34-38 and predelivery (-14-0 days prior to delivery) and postpartum (>6 weeks after delivery). The 2.5th and 97.5th percentiles were calculated according to the recommendations of the International Federation of Clinical Chemistry on the statistical treatment of reference values. Reference values for alpha(1)-acid glycoprotein, alpha(1)-antitrypsin, albumin, haptoglobin, CRP, IgA, IgG and IgM are reported. Most of these proteins changed during normal pregnancy, as a reflection of the major physiological and biochemical changes that occur in pregnancy. A laboratory test result from a pregnant woman should be compared with pregnancy-specific reference intervals.
authors.affiliation: Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden. anders.larsson@akademiska.se
authors.forename: Anders
authors.initials: A
authors.lastname: Larsson
authors.forename: Maria
authors.initials: M
authors.lastname: Palm
authors.forename: Lars-Olof
authors.initials: LO
authors.lastname: Hansson
authors.forename: Samar
authors.initials: S
authors.lastname: Basu
authors.forename: Ove
authors.initials: O
authors.lastname: Axelsson
mesh_terms: D000328:Adult; D000418:Albumins / Q000378:metabolism; D001724:Birth Weight; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006242:Haptoglobins / Q000378:metabolism; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007231:Infant, Newborn; D008297:Male; D009961:Orosomucoid / Q000378:metabolism; D011247:Pregnancy / Q000097:blood / Q000276:immunology*; D012016:Reference Values; D000515:alpha 1-Antitrypsin / Q000097:blood
chemical_list: D000418:Albumins; D006242:Haptoglobins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D009961:Orosomucoid; D000515:alpha 1-Antitrypsin; D002097:C-Reactive Protein