Management of evaporative dry eye in ectrodactyly-ectodermal dysplasia-clefting syndrome.
OBJECTIVE
The purpose of this study is to report the features of dry eye and ocular surface disease in an unusual case of ectrodactyly-ectodermal dysplasia-clefting (EEC) syndrome.


METHODS
A single observational case report of a 22-year-old Japanese male with evaporative dry eye and corneal epithelial disease because of lipid layer abnormality resulting from meibomian gland agenesis was treated successfully with low dose lipid base ointment application.


CONCLUSIONS
The clinical features of the dry eye and ocular surface disease and management issues are discussed.


CONCLUSIONS
Low dose lipid base ointment application may be a promising treatment modality for the ocular surface disease in ectrodactyly-ectodermal dysplasia (EEC)-clefting syndrome, which seems to help in alleviating the subjective complaints and in improving the objective clinical findings.
Ota
Yu
Y
Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Matsumoto
Yukihiro
Y
Dogru
Murat
M
Goto
Eiki
E
Uchino
Yuichi
Y
Endo
Koji
K
Tsubota
Kazuo
K
D000328:Adult; D003316:Corneal Diseases / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D015352:Dry Eye Syndromes / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D004476:Ectodermal Dysplasia / Q000150:complications* / Q000235:genetics; D005124:Eye Abnormalities / Q000150:complications* / Q000235:genetics; D005532:Foot Deformities, Congenital / Q000150:complications* / Q000235:genetics; D006228:Hand Deformities, Congenital / Q000150:complications* / Q000235:genetics; D006801:Humans; D008055:Lipids / Q000172:deficiency; D008297:Male; D008537:Meibomian Glands / Q000002:abnormalities*; D015242:Ofloxacin / Q000008:administration & dosage; D009824:Ointments; D009883:Ophthalmic Solutions / Q000008:administration & dosage; D013577:Syndrome; D013666:Tears / Q000378:metabolism
D008055:Lipids; D009824:Ointments; D009883:Ophthalmic Solutions; D015242:Ofloxacin