title: Clinicoradiological features of rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle: report of four cases and literature review.
abstract: BACKGROUND
  Rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle is a recently characterized rare tumor entity. Despite benign histological features and a reported favorable postoperative course, there is still limited clinical experience with this tumor.
  
  
  METHODS
  Retrospective analysis of the clinical, radiological, and surgical data in four patients with RGNT was performed. Mean age at diagnosis was 35 years, and the median follow-up was 19 (range 2-30) months. The results were compared with the literature.
  
  
  RESULTS
  Patient 1 presented on an emergency basis due to intratumoral hemorrhage and tumor enlargement followed by life-threatening obstructive hydrocephalus. Patient 2 suffered from headaches and left-sided hemiparesthesia 6 months prior to surgery. Patient 3 developed headaches with nausea and vomiting, followed by left-sided tinnitus 1 year prior to surgery. In patient 4, RGNT was detected incidentally. No differentiating radiological characteristics were seen except for the presence of minute satellite lesions in two patients. Histopathological findings were distinct and showed their typical biphasic neurocytic and glial architecture. No progression/recurrence was seen in the postoperative course.
  
  
  CONCLUSIONS
  The spectrum of presenting symptoms of RGNT is wide, nonspecific, and typically depends on tumor size and extent. This tumor entity should be considered in the differential diagnosis of posterior fossa masses in order to avoid undue surgical aggressiveness.
authors.affiliation: Department of Neurosurgery, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
authors.forename: Franz
authors.initials: F
authors.lastname: Marhold
authors.forename: Matthias
authors.initials: M
authors.lastname: Preusser
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Dietrich
authors.forename: Daniela
authors.initials: D
authors.lastname: Prayer
authors.forename: Thomas
authors.initials: T
authors.lastname: Czech
mesh_terms: D000328:Adult; D002551:Cerebral Ventricle Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D020546:Fourth Ventricle / Q000000981:diagnostic imaging* / Q000473:pathology; D018303:Ganglioglioma / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000628:therapy; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D005904:Glial Fibrillary Acidic Protein
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