Hydroxyl and superoxide radical scavenging abilities of chromonyl-thiazolidine-2,4-dione compounds.
The oxygen free radical scavenging activities of 15 chromonyl-thiazolidine-2,4-dione compounds (CTDs) were examined in chemical systems producing superoxide anion radicals, O2(-*) (potassium superoxide-18-crown-6 ether-DMSO), and hydroxyl radicals, HO(*) (a Fenton reaction: Fe(II)-H2O2-sodium trifluoroacetate, pH 6.15). Chemiluminescence and electron spin resonance (ESR) spectroscopy using 5,5-dimethyl-1-pyrroline-1-oxide (DMPO) as spin trap were applied to evaluate antioxidant behaviour of CTDs towards the oxygen radicals. The results indicated that 11 of the 15 tested compounds showed a significant inhibitory effect on the chemiluminescence generated from the O2(-*)-generating system, ranging from 41 to 86%, and 13 CTDs quenched the ESR signal of the DMPO-OH spin adduct by 33-86%, at a concentration of 1 mmol L(-1). Our findings demonstrate that CTDs could be good free radical scavengers.
Kruk
Irena
I
Institute of Physics, Szczecin University of Technology, Al. Piastów 48/49, 70-311 Szczecin, Poland.
Bozdağ-Dündar
Oya
O
Ertan
Rahmiye
R
Aboul-Enein
Hassan Y
HY
Michalska
Teresa
T
D002867:Chromones / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D016166:Free Radical Scavengers / Q000737:chemistry*; D006861:Hydrogen Peroxide; D017665:Hydroxyl Radical / Q000737:chemistry*; D007501:Iron; D008163:Luminescent Measurements; D013481:Superoxides / Q000737:chemistry*; D045162:Thiazolidinediones / Q000737:chemistry*
D002867:Chromones; C045076:Fenton's reagent; D016166:Free Radical Scavengers; D045162:Thiazolidinediones; C500090:thiazolidine-2,4-dione; D013481:Superoxides; D017665:Hydroxyl Radical; D006861:Hydrogen Peroxide; D007501:Iron