ppGpp analogues as antibacterial compounds.
Immediately after sensing the inception of amino acid starvation, bacteria respond pleiotropically with the stringent response via RelA, mainly resulting in the accumulation of the signal molecule (p)ppGpp. A series of analogues of ppGpp that inhibit RelA activity was prepared in order to control the ability of bacteria cells to react to the changes in their environment. Some of those compounds presented very clear inhibitory effect on both Gram positive and negative bacteria in vitro.
Ezequiel
Wexselblatt
W
Hebrew University of Jerusalem, School of Pharmacy, Department of Medicinal Chemistry and Natural Products, Jerusalem, Israel.
Jehoshua
Katzhendler
K
Gad
Glaser
G
Roee
Vidavski
V
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D006159:Guanosine Tetraphosphate / Q000031:analogs & derivatives*; D008025:Ligases / Q000037:antagonists & inhibitors*
D000900:Anti-Bacterial Agents; D006159:Guanosine Tetraphosphate; D008025:Ligases; C028812:guanosine 3',5'-polyphosphate synthetases