DNA and RNA quadruplex ligands.
Guanine-rich nucleic acids can adopt unusual structures called guanine quadruplexes (G4) based on stacked guanine quartets. Both RNA and DNA backbones are compatible with G4 formation. As RNA and DNA quadruplexes may be recognized by ligands, it is important to understand the rules that govern the stability and specificity of these complexes. We explore the binding of a pyridine dicarboxamide derivative to various oligoribo- and oligodeoxyribo-nucleotides.
De Cian
Anne
A
Muséum national d'Histoire naturelle USM 503, INSERM U565, CNRS UMR5153, Paris, France.
Gros
Julien
J
Guédin
Aurore
A
Haddi
Meriem
M
Lyonnais
Sébastien
S
Guittat
Lionel
L
Riou
Jean-François
JF
Trentesaux
Chantal
C
Saccà
Barbara
B
Lacroix
Laurent
L
Alberti
Patrizia
P
Mergny
Jean-Louis
JL
D000818:Animals; D004247:DNA / Q000737:chemistry*; D054856:G-Quadruplexes; D006801:Humans; D008024:Ligands; D011725:Pyridines / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*; D016615:Telomere / Q000737:chemistry
C502660:2,6-N,N'-methyl-quinolinio-3-yl-pyridine dicarboxamide; D008024:Ligands; D011725:Pyridines; D011804:Quinolines; D012313:RNA; D004247:DNA