Helicobacter and gastric malignancies.
Individuals infected with Helicobacter pylori, a stomach colonizing bacteria, have an increased risk of developing gastric malignancies. The risk for developing cancer relates to the physiologic and histologic changes that H. pylori infection induces in the stomach. In the last year numerous studies have been conducted in order to characterize the association between H. pylori infection and gastric cancer. These studies range from epidemiologic approaches aiming at the identification of environmental, host genetic, and bacterial factors associated with risk of gastric cancer, to molecular and cell biology approaches aiming at understanding the interaction between H. pylori and the transforming epithelial cell. In this review an account of the last year's research activity on the relationship between H. pylori and gastric cancer will be given.
Ferreira
António Carlos
AC
IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal.
Isomoto
Hajime
H
Moriyama
Masatsugu
M
Fujioka
Toshio
T
Machado
José Carlos
JC
Yamaoka
Yoshio
Y
D000818:Animals; D000942:Antigens, Bacterial / Q000235:genetics / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D044127:Epigenesis, Genetic; D005753:Gastric Mucosa / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology; D016481:Helicobacter Infections / Q000150:complications* / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology; D016480:Helicobacter pylori / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology; D006801:Humans; D015398:Signal Transduction; D013274:Stomach Neoplasms / Q000150:complications / Q000276:immunology / Q000382:microbiology* / Q000503:physiopathology; D037521:Virulence Factors / Q000235:genetics / Q000378:metabolism
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D037521:Virulence Factors; C080866:cagA protein, Helicobacter pylori
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