[Coagulopathy and differentiation syndrome: the main complications of the initial treatment of acute promyelocytic leukemia].
Two main causes of early mortality of acute promyelocytic leukemia (APL) are rewieved, unique type ofcoagulopathy typical for APL and differentiation syndrome sometimes complicating treatment of APL with all-trans retinoic acid (ATRA) or arsenic trioxide (ATO). The information covers analysis of the patophysiologies of both conditions and also recommendations considering treatments and preventive measures.
Korístek
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Interní hematoonkologická klinika Lékarské fakulty MU a FN Brno. Zdenek.Koristek@seznam.cz
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D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000009:adverse effects* / Q000627:therapeutic use; D004211:Disseminated Intravascular Coagulation / Q000209:etiology*; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000150:complications / Q000188:drug therapy*; D007964:Leukocytosis / Q000139:chemically induced*; D010087:Oxides / Q000009:adverse effects* / Q000627:therapeutic use; D012131:Respiratory Insufficiency / Q000139:chemically induced*; D013577:Syndrome; D013921:Thrombocytopenia / Q000209:etiology; D014212:Tretinoin / Q000009:adverse effects* / Q000627:therapeutic use
D000970:Antineoplastic Agents; D001152:Arsenicals; D010087:Oxides; D014212:Tretinoin; D000077237:Arsenic Trioxide