title: Association of MICA alleles with psoriatic arthritis and its clinical forms. A multicenter Italian study.
abstract: OBJECTIVE
  Analysis of the association between psoriatic arthritis (PsA) clinical forms and MICA gene transmembrane polymorphisms.
  
  
  METHODS
  Patients were classified as having peripheral asymmetric oligoarthritis (AO), peripheral symmetric poly-arthritis (PA) and spondylitis (SP), or disease combinations (PA/SP, OA/SP). Two hundred and twenty-six patients with PsA were typed for MICA exon 5 microsatellite (TM) by heteroduplex analysis and compared with 225 normal controls.
  
  
  RESULTS
  MICA-TM microsatellite typing revealed that, among the different clinical forms of PsA, only the combined PA/SP subset shows a significant positive association with MICA-A9 and a lower frequency of MICA-A4, A5 genotype in PsA patients with a decrease, only in the PA/SP cohort, of all MICA-A5 combinations except MICA-A5, -A9.
  
  
  CONCLUSIONS
  These results suggest a role for genes within the HLA region in the pathogenesis of PsA, and reinforce the idea that the different forms of PsA may have heterogeneous genetic basis.
authors.affiliation: 2nd Chair of Rheumatology and Rheumatology Unit, Department of Medical Sciences, University of Cagliari, Cagliari, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Mameli
authors.forename: A
authors.initials: A
authors.lastname: Cauli
authors.forename: E
authors.initials: E
authors.lastname: Taccari
authors.forename: R
authors.initials: R
authors.lastname: Scarpa
authors.forename: L
authors.initials: L
authors.lastname: Punzi
authors.forename: G
authors.initials: G
authors.lastname: Lapadula
authors.forename: R
authors.initials: R
authors.lastname: Peluso
authors.forename: R
authors.initials: R
authors.lastname: Ramonda
authors.forename: A
authors.initials: A
authors.lastname: Spadaro
authors.forename: F
authors.initials: F
authors.lastname: Iannone
authors.forename: V
authors.initials: V
authors.lastname: Fanni
authors.forename: A
authors.initials: A
authors.lastname: Vacca
authors.forename: G
authors.initials: G
authors.lastname: Passiu
authors.forename: M T
authors.initials: MT
authors.lastname: Fiorillo
authors.forename: C
authors.initials: C
authors.lastname: Carcassi
authors.forename: R
authors.initials: R
authors.lastname: Sorrentino
authors.forename: A
authors.initials: A
authors.lastname: Mathieu
mesh_terms: D015535:Arthritis, Psoriatic / Q000145:classification / Q000235:genetics*; D016022:Case-Control Studies; D015331:Cohort Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D007558:Italy; D018895:Microsatellite Repeats / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A