11-Hydroxymonocerin from the plant endophytic fungus Exserohilum rostratum.
A new analogue of monocerin, 11-hydroxymonocerin (2), along with monocerin (1) and 12-hydroxymonocerin (3) were isolated from cultures of Exserohilum rostratum, a fungal strain endophytic in Stemona sp. The structure of 2 was determined by analysis of NMR and MS data and by comparison of spectroscopic data to those of 1. Monocerin (1) and 11-hydroxymonocerin (2) displayed activity against Plasmodium falciparum (K1, multidrug-resistant strain) with IC50 values of 0.68 and 7.70 microM, respectively. None of the compounds were cytotoxic against any of the tumor cell lines tested.
Sappapan
Ruengrit
R
Program in Biotechnology, Chulalongkorn University, Bangkok 10330 Thailand.
Sommit
Damrong
D
Ngamrojanavanich
Nattaya
N
Pengpreecha
Somchai
S
Wiyakrutta
Suthep
S
Sriubolmas
Nongluksna
N
Pudhom
Khanitha
K
D000818:Animals; D001203:Ascomycota / Q000737:chemistry*; D018432:Drug Resistance, Multiple / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D018515:Plant Leaves / Q000382:microbiology; D010963:Plasmodium falciparum / Q000187:drug effects; D041901:Stemonaceae / Q000382:microbiology
C532736:11-hydroxymonocerin; D007783:Lactones; C485193:monocerin