Early familial dilated cardiomyopathy: identification with determination of disease state parameter from cine MR image data.
OBJECTIVE
To characterize early changes in cardiac anatomy and function for lamin A/C gene (LMNA) mutation carriers by using magnetic resonance (MR) imaging and to develop tools to analyze and visualize the findings.


METHODS
The ethical review board of the institution approved the study, and informed written consent was obtained. The patient group consisted of 12 subjects, seven women (mean age, 36 years; age range, 18-54 years) and five men (mean age, 28 years; age range, 18-39 years) of Finnish origin, who were each heterozygotes with one LMNA mutation that may cause familial dilated cardiomyopathy (DCM). All the subjects were judged to be healthy with transthoracic echocardiography. The control group consisted of 14 healthy subjects, 11 women (mean age, 41 years; range, 23-54 years) and three men (mean age, 45 years; range, 34-57 years), of Finnish origin. Cine steady state free precession MR imaging was performed with a 1.5-T system. The volumes, wall thickness, and wall motion of both left ventricle (LV) and right ventricle were assessed. A method combining multiple MR image parameters was used to generate a global cardiac function index, the disease state parameter (DSP). A visual fingerprint was generated to assess the severity of familial DCM.


RESULTS
The mean DSP of the patient group (0.69 +/- 0.15 [standard deviation]) was significantly higher than that of the control group (0.32 +/- 0.13) (P = .00002). One subject had an enlarged LV.


CONCLUSIONS
Subclinical familial DCM was identified by determination of the DSP with MR imaging, and this method might be used to recognize familial DCM at an early stage.
Koikkalainen
Juha R
JR
VTT Technical Research Centre of Finland, Tekniikankatu 1, FIN-33101 Tampere, Finland. juha.koikkalainen@vtt.fi
Antila
Margareta
M
Lötjönen
Jyrki M P
JM
Heliö
Tiina
T
Lauerma
Kirsi
K
Kivistö
Sari M
SM
Sipola
Petri
P
Kaartinen
Maija A
MA
Kärkkäinen
Satu T J
ST
Reissell
Eeva
E
Kuusisto
Johanna
J
Laakso
Markku
M
Oresic
Matej
M
Nieminen
Markku S
MS
Peuhkurinen
Keijo J
KJ
D000293:Adolescent; D000328:Adult; D002311:Cardiomyopathy, Dilated / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D005260:Female; D006801:Humans; D034904:Lamin Type A / Q000235:genetics; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009154:Mutation
C494847:LMNA protein, human; D034904:Lamin Type A