Hypocalcemia in a patient with osteosarcoma and 22q11.2 deletion syndrome.
Hypocalcemia is a rare complication of osteosarcoma, having been described in only 4 reports. We present the case of a 16-year-old male with metastatic osteosarcoma of the right humerus who was found to have severe asymptomatic hypocalcemia. Cytogenetic analysis of peripheral blood revealed a microdeletion in band 22q11.2. Following amputation of the tumor-bearing extremity, the patient's calcium levels increased, but did not normalize. These findings suggested that the etiology of his hypocalcemia was osteoblastic utilization of calcium by the tumor, exacerbated by 22q11.2 deletion syndrome.
Mussai
Francis J
FJ
Pediatric Oncology Branch, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Cunningham
Lea C
LC
Rezvani
Geoffrey
G
Stratakis
Constantine A
CA
Reynolds
James C
JC
Nesterova
Galina
G
Henshaw
Robert M
RM
Levine
Jason E
JE
Helman
Lee J
LJ
Arthur
Diane C
DC
Kim
Su Young
SY
D015502:Absorptiometry, Photon; D000293:Adolescent; D000671:Amputation, Surgical; D001859:Bone Neoplasms / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D004062:DiGeorge Syndrome / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D006811:Humerus / Q000473:pathology / Q000601:surgery; D006996:Hypocalcemia / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D017403:In Situ Hybridization; D008297:Male; D012516:Osteosarcoma / Q000150:complications* / Q000473:pathology / Q000503:physiopathology
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