Utilization of DC-SIGN for entry of feline coronaviruses into host cells.
The entry and dissemination of viruses in several families can be mediated by C-type lectins such as DC-SIGN. We showed that entry of the serotype II feline coronavirus strains feline infectious peritonitis virus (FIPV) WSU 79-1146 and DF2 into nonpermissive mouse 3T3 cells can be rescued by the expression of human DC-SIGN (hDC-SIGN) and that infection of a permissive feline cell line (Crandall-Reese feline kidney) was markedly enhanced by the overexpression of hDC-SIGN. Treatment with mannan considerably reduced infection of feline monocyte-derived cells expressing DC-SIGN, indicating a role for FIPV infection in vivo.
Regan
Andrew D
AD
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA.
Whittaker
Gary R
GR
D016475:3T3 Cells; D000818:Animals; D018826:CD13 Antigens / Q000502:physiology; D002415:Cats; D015815:Cell Adhesion Molecules / Q000502:physiology*; D016765:Coronavirus, Feline / Q000502:physiology*; D006801:Humans; D037181:Lectins, C-Type / Q000502:physiology*; D008351:Mannans / Q000494:pharmacology; D051379:Mice; D011956:Receptors, Cell Surface / Q000502:physiology*; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
D018826:CD13 Antigens; D015815:Cell Adhesion Molecules; D037181:Lectins, C-Type; D008351:Mannans; D011956:Receptors, Cell Surface; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
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