Caudal end of the rat spinal dorsal horn.
We have previously demonstrated that the transformation of the caudal spinal cord through the conus medullaris to the filum terminale takes place in three steps. In the conus medullaris the twin layers of CGRP-immunoreactive and IB4-labeled primary afferent fibers as well as the translucent portion of the superficial dorsal horn equivalent to the substantia gelatinosa discontinue before the complete removal of the dorsal horn. Parallel with these changes VGLUT1-immunoreactive myelinated primary afferent fibers arborize not only in the deep layers but also in the entire extension of the remaining dorsal horn, while scattered CGRP fibers still remains at the margin of and deep in the dorsal horn. PKCgamma-immunoreactive dorsal horn neurons discontinue parallel with the disappearance of the IB4-labeled nerve fibers. These observations suggest that in the dorsal horn certain neurons are linked to the substantia gelatinosa, while others are substantia gelatinosa-independent neurons.
Réthelyi
Miklós
M
Szentágothai János Laboratory, Department of Anatomy, Histology and Embryology, Semmelweis University, Tuzoltó utca 58, Budapest, Hungary. rethelyi@ana.sote.hu
Horváth-Oszwald
Erzsébet
E
Boros
Csaba
C
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism; D005260:Female; D006023:Glycoproteins / Q000378:metabolism; D037102:Lectins / Q000378:metabolism; D008297:Male; D009412:Nerve Fibers / Q000378:metabolism; D009475:Neurons, Afferent / Q000378:metabolism; D020671:Posterior Horn Cells / Q000033:anatomy & histology / Q000378:metabolism*; D011493:Protein Kinase C / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000166:cytology*; D053675:Versicans; D050598:Vesicular Glutamate Transport Protein 1 / Q000378:metabolism
D006023:Glycoproteins; D037102:Lectins; C493466:Slc17a7 protein, rat; C508324:Vcan protein, rat; D050598:Vesicular Glutamate Transport Protein 1; D053675:Versicans; C087857:protein kinase C gamma; D011493:Protein Kinase C; D015740:Calcitonin Gene-Related Peptide