Chemistry and structure-activity relationship of antibacterial nucleoside natural products.
Synthetic methodology of the caprazamycins, which are promising antibacterial nucleoside natural products, was developed. Palmitoylcaprazol, which possesses a simple fatty acyl side chain at the diazepanone moiety of caprazamycins, has been synthesized and exhibited antibacterial activity against pathogens threatening a public health. Simplification of the caprazamycins was further pursued to develop diketopiperazine analogs.
Ichikawa
Satoshi
S
Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo, Japan. ichikawa@pharm.hokudai.ac.jp
Matsuda
Akira
A
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001381:Azepines / Q000138:chemical synthesis / Q000737:chemistry; D001685:Biological Factors / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014529:Uridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
D000900:Anti-Bacterial Agents; D001381:Azepines; D001685:Biological Factors; C512216:caprazol; D014529:Uridine