title: Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors.
abstract: Biological systems are integrated networks constantly responding to internal and external stimulators. Understanding the intrinsic response to an imbalanced system provides the opportunity to develop therapeutic approaches to reinstate the natural balanced state. Increasing evidence suggests that members of the nuclear receptor superfamily integrate both inflammatory and metabolic signals to maintain homeostasis in immune cells such as macrophages and lymphocytes. PPAR and LXR are nuclear receptors activated by fatty acid and cholesterol derivatives respectively that control the expression of an array of genes involved in lipid metabolism and inflammation. Recent studies have uncovered distinct mechanisms for transcriptional regulation of metabolic and inflammatory target genes by PPAR and LXR and have expanded the biology of these receptors to include roles in alternative macrophage activation and adaptive immunity.
authors.affiliation: Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, 675 Charles E. Young Drive, Los Angeles, CA 90049, USA.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Hong
authors.forename: Peter
authors.initials: P
authors.lastname: Tontonoz
mesh_terms: D000818:Animals; D000917:Antibody Formation; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000235:genetics / Q000378:metabolism; D000071518:Liver X Receptors; D008262:Macrophage Activation; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D008954:Models, Biological; D057093:Orphan Nuclear Receptors; D047492:Peroxisome Proliferator-Activated Receptors / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D004268:DNA-Binding Proteins; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D047492:Peroxisome Proliferator-Activated Receptors; D018160:Receptors, Cytoplasmic and Nuclear
references.citation: Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1268-73
references.pmid: 12540828
references.citation: Annu Rev Cell Dev Biol. 2000;16:459-81
references.pmid: 11031244
references.citation: J Biol Chem. 2006 Oct 27;281(43):32197-206
references.pmid: 16943198
references.citation: Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16237-42
references.pmid: 12444248
references.citation: Mol Cell. 2003 Oct;12(4):805-16
references.pmid: 14580333
references.citation: Nat Rev Immunol. 2003 Jan;3(1):23-35
references.pmid: 12511873
references.citation: Cell. 2005 Sep 9;122(5):707-21
references.pmid: 16143103
references.citation: Nature. 1990 Oct 18;347(6294):645-50
references.pmid: 2129546
references.citation: Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5306-11
references.pmid: 11309497
references.citation: Nature. 1999 Jul 22;400(6742):378-82
references.pmid: 10432118
references.citation: Cell Metab. 2008 Jun;7(6):496-507
references.pmid: 18522831
references.citation: Mol Cell. 2000 Mar;5(3):545-55
references.pmid: 10882139
references.citation: Cell. 2008 Jul 11;134(1):97-111
references.pmid: 18614014
references.citation: Nature. 1996 Oct 24;383(6602):728-31
references.pmid: 8878485
references.citation: Genes Dev. 2000 Jan 15;14(2):121-41
references.pmid: 10652267
references.citation: Nature. 2005 Sep 29;437(7059):759-63
references.pmid: 16127449
references.citation: Mol Cell. 2007 Jan 12;25(1):57-70
references.pmid: 17218271
references.citation: J Invest Dermatol. 2003 Feb;120(2):246-55
references.pmid: 12542530
references.citation: J Biol Chem. 1997 Feb 7;272(6):3137-40
references.pmid: 9013544
references.citation: Proc Natl Acad Sci U S A. 2002 May 28;99(11):7604-9
references.pmid: 12032330
references.citation: Cell Metab. 2007 Aug;6(2):137-43
references.pmid: 17681149
references.citation: J Biol Chem. 2003 Mar 21;278(12):10443-9
references.pmid: 12531895
references.citation: Endocr Rev. 1999 Oct;20(5):649-88
references.pmid: 10529898
references.citation: Annu Rev Biochem. 2001;70:341-67
references.pmid: 11395411
references.citation: Cell. 1998 Apr 17;93(2):241-52
references.pmid: 9568716
references.citation: Nature. 1992 Aug 27;358(6389):771-4
references.pmid: 1324435
references.citation: Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7614-9
references.pmid: 9636198
references.citation: J Clin Invest. 2006 Mar;116(3):607-14
references.pmid: 16511593
references.citation: Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4277-82
references.pmid: 18337495
references.citation: Mol Endocrinol. 2008 Jun;22(6):1394-402
references.pmid: 18323470
references.citation: Cell Metab. 2008 Jun;7(6):485-95
references.pmid: 18522830
references.citation: Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7355-9
references.pmid: 8041794
references.citation: Cell. 1998 May 29;93(5):693-704
references.pmid: 9630215
references.citation: Cell. 1995 Dec 15;83(6):841-50
references.pmid: 8521508
references.citation: Annu Rev Cell Dev Biol. 2004;20:455-80
references.pmid: 15473848
references.citation: Cell. 1994 Dec 30;79(7):1147-56
references.pmid: 8001151
references.citation: Genes Dev. 1994 May 15;8(10):1224-34
references.pmid: 7926726
references.citation: Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17813-8
references.pmid: 15601766
references.citation: Nat Med. 2001 Jan;7(1):48-52
references.pmid: 11135615
references.citation: Science. 2003 Oct 17;302(5644):453-7
references.pmid: 12970571
references.citation: Annu Rev Cell Dev Biol. 2000;16:145-71
references.pmid: 11031233
references.citation: Nature. 2007 Jun 28;447(7148):1116-20
references.pmid: 17515919
references.citation: Science. 2000 Sep 1;289(5484):1524-9
references.pmid: 10968783
references.citation: Nat Med. 2003 Feb;9(2):213-9
references.pmid: 12524534
references.citation: J Clin Invest. 2007 Aug;117(8):2337-46
references.pmid: 17657314
references.citation: J Clin Invest. 2004 Dec;114(11):1564-76
references.pmid: 15578089
references.citation: Circulation. 1999 Jun 22;99(24):3125-31
references.pmid: 10377075
references.citation: Mol Cell. 2001 Jan;7(1):161-71
references.pmid: 11172721
references.citation: Proc Natl Acad Sci U S A. 2003 May 27;100(11):6712-7
references.pmid: 12740443
references.citation: Cell. 2004 Oct 15;119(2):299-309
references.pmid: 15479645