title: Folic acid in ruminant nutrition: a review.
abstract: Folic acid plays an essential role in DNA and methionine metabolism. Micro-organisms in the rumen can synthesise folates, but it has not been verified that these amounts are sufficient to achieve the best efficiency of dairy cows. However, the amount of folates synthesised in the rumen could possibly, to some extent, be affected by the forage:concentrate ratio. Degradation of orally supplemented folic acid in the rumen seems to be very high (about 97%), as supplementation of folic acid hardly increases folate concentrations in the digesta at the duodenum. However, it must be considered that dietary supplements of folic acid higher than 0.5 mg/kg body weight increased serum folate concentrations in all available studies and milk folate concentrations in most studies. Additionally, milk production tended to be increased in some studies. Therefore, degradation of folic acid in the rumen may be overestimated as folates can be absorbed at the proximal duodenum. For future research it is necessary to consider the whole flow and the metabolic pathways of folates from the rumen to duodenum, blood, tissue, milk and transfer to calf to declare requirement values for cows. Consequently, the present review discusses current knowledge and emphasises areas for future research.
authors.affiliation: Institute of Animal Nutrition, Friedrich-Loeffler-Institute, Federal Research Institute of Animal Health, Bundesallee 50, 38116 Braunschweig, Germany. veronika.ragaller@fli.bund.de
authors.forename: Veronika
authors.initials: V
authors.lastname: Ragaller
authors.forename: Liane
authors.initials: L
authors.lastname: Hüther
authors.forename: Peter
authors.initials: P
authors.lastname: Lebzien
mesh_terms: D000821:Animal Feed; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D002417:Cattle / Q000378:metabolism*; D003612:Dairying; D019587:Dietary Supplements; D004386:Duodenum / Q000378:metabolism / Q000382:microbiology; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism*; D007408:Intestinal Absorption; D008099:Liver / Q000737:chemistry / Q000378:metabolism; D008892:Milk / Q000737:chemistry / Q000378:metabolism; D012417:Rumen / Q000378:metabolism* / Q000382:microbiology
chemical_list: D005492:Folic Acid