Stereospecific total synthesis of somocystinamide A.
The first total synthesis of somocystinamide A, a disulfide dimer with extremely labile enamide functional groups, was accomplished in a concise and stereospecific manner. Somocystinamide A is reported to possess exceptionally potent antiangiogenic and tumoricidal activities. The current work should enable further pharmacological investigation of this important natural product.
Suyama
Takashi L
TL
Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.
Gerwick
William H
WH
D000577:Amides / Q000737:chemistry; D001688:Biological Products / Q000737:chemistry; D004220:Disulfides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D000577:Amides; D001688:Biological Products; D004220:Disulfides; C454639:Somocystinamide A
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