Effective synthesis of photosensitive oligodeoxynucleotides.
In this paper, the synthesis of various vinyl substituted photosensitive pyrimidine nucleosides and nucleotides is described; starting from 5-Iodo-2'-deoxyuridine (IdU) or oligodeoxynucleotides (ODN) containing IdU, which has been attached using an automated batch stop-flow microwave apparatus. The utility of the Pd(0) cross-coupling to photosensitive pyrimidine is expanded herein to include the reaction of glass-supported ODN containing IdU under Heck and Suzuki conditions.
Ogino
Masayuki
M
Innovation Plaza Ishikawa, Japan Science and Technolgy Agency, Nomi, Ishikawa 923-1211, Japan.
Taya
Yuta
Y
Fujimoto
Kenzo
K
D007065:Idoxuridine / Q000737:chemistry*; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry / Q000528:radiation effects; D010165:Palladium / Q000737:chemistry; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis / Q000737:chemistry
D009838:Oligodeoxyribonucleotides; D011741:Pyrimidine Nucleosides; D010165:Palladium; D007065:Idoxuridine