Microstructural thalamic changes in schizophrenia: a combined anatomic and diffusion weighted magnetic resonance imaging study.
OBJECTIVE
Several magnetic resonance imaging (MRI) and postmortem studies have supported the role of the thalamus in the pathophysiology of schizophrenia. Interestingly, a recent small diffusion weighted imaging (DWI) study showed abnormal thalamic microstructure in patients with schizophrenia. The objective of our study was to use structural MRI and DWI to explore for the first time both thalamic volumes and integrity in schizophrenia.


METHODS
We measured thalamic volumes and apparent diffusion coefficient (ADC) measures bilaterally in 71 patients with schizophrenia, representative of those living in the geographically defined catchment area of South Verona (i.e., 100 000 inhabitants), and 75 individuals without schizophrenia. The presence of the adhesio interthalamica was also detected.


RESULTS
We found no significant differences in thalamus size between patients with schizophrenia and participants in the control group, with only a trend for decreased left volumes. No abnormal frequency of the adhesio interthalamica was found. In contrast, significantly increased thalamic ADC values were shown in schizophrenia patients. Age significantly inversely correlated with thalamic volumes in both groups and correlated positively with posterior ADCs in patients with schizophrenia. No significant associations between clinical variables and either volumes or ADC values were reported.


CONCLUSIONS
Widespread altered microstructure integrity and partially preserved thalamus size were found in schizophrenia patients. Therefore, subtle thalamic structural abnormalities are present in schizophrenia, even with maintained volumes. This may result from disruption at the cytoarchitecture level, ultimately supporting corticothalamic misconnection. Future imaging studies should further explore thalamic tissue coherence and its role for cognitive disturbances in patients at high risk for schizophrenia and in first-degree relatives.
Agarwal
Nivedita
N
Department of Medical and Morphological Research, Section of Radiology, University of Udine, Udine, Italy.
Rambaldelli
Gianluca
G
Perlini
Cinzia
C
Dusi
Nicola
N
Kitis
Omer
O
Bellani
Marcella
M
Cerini
Roberto
R
Isola
Miriam
M
Versace
Amelia
A
Balestrieri
Matteo
M
Gasparini
Anna
A
Mucelli
Roberto Pozzi
RP
Tansella
Michele
M
Brambilla
Paolo
P
D000328:Adult; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000175:diagnosis*; D013788:Thalamus / Q000033:anatomy & histology*
Schizophr Res. 2005 Feb 1;73(1):91-101
15567081
Int Rev Psychiatry. 2007 Aug;19(4):459-68
17671878
J Comp Neurol. 1982 Oct 20;211(2):193-214
7174890
Int Rev Psychiatry. 2007 Aug;19(4):313-4
17671864
Schizophr Res. 2001 Apr 15;49(1-2):1-52
11343862
Schizophr Res. 2002 May 1;55(1-2):89-92
11955967
Psychiatry Res. 2006 Oct 30;147(2-3):145-51
16945509
Neuropsychopharmacology. 2002 Apr;26(4):546-51
11927179
Am J Psychiatry. 2004 Feb;161(2):305-14
14754780
Eur Psychiatry. 2006 Jul;21(5):291-9
16406503
Schizophr Res. 2003 Apr 1;60(2-3):141-55
12591578
J Comp Neurol. 1985 Feb 8;232(2):219-28
3973091
Am J Psychiatry. 2001 Aug;158(8):1314-6
11481168
Schizophr Res. 2002 Dec 1;58(2-3):135-44
12409153
Am J Psychiatry. 2000 Apr;157(4):644-7
10739431
Psychiatry Res. 2006 Nov 22;148(1):61-6
17070020
Neurosci Lett. 2006 Jan 9;392(1-2):16-21
16171947
Neuroimage. 2005 Apr 15;25(3):771-82
15808978
Epidemiol Psichiatr Soc. 2005 Oct-Dec;14(4):188-93
16396426
Am J Psychiatry. 1996 Feb;153(2):191-9
8561198
Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9985-90
8790444
Arch Gen Psychiatry. 1990 Jan;47(1):35-44
2294854
Cereb Cortex. 2000 Mar;10(3):206-19
10731217
Am J Psychiatry. 1998 Dec;155(12):1784-6
9842796
Biol Psychiatry. 2006 Aug 1;60(3):235-41
16458267
J Neurophysiol. 1996 Sep;76(3):1367-95
8890259
Arch Gen Psychiatry. 2003 Oct;60(10):983-91
14557143
Am J Psychiatry. 2001 Apr;158(4):618-24
11282698
Science. 1994 Oct 14;266(5183):294-8
7939669
Biol Psychiatry. 2004 Feb 1;55(3):201-7
14744459
J Neurophysiol. 1982 Aug;48(2):521-44
7119861
Am J Psychiatry. 2005 Sep;162(9):1733-5
16135634
Schizophr Res. 2004 Dec 1;71(2-3):473-84
15474918
Br J Psychiatry. 2003 Aug;183:167-9
12893671
J Neuroimaging. 1998 Jul;8(3):159-63
9664852
Br J Psychiatry. 2007 Aug;191:113-9
17666494
Arch Neurol. 2002 Sep;59(9):1406-12
12223026
Brain Res. 2006 Oct 9;1114(1):125-37
16935269
Am J Psychiatry. 2006 Mar;163(3):463-9
16513868
J Neural Transm (Vienna). 2006 Jul;113(7):907-28
16252070
Biol Psychiatry. 2006 May 15;59(10):929-39
16427028
Am J Psychiatry. 2000 May;157(5):823-5
10784480
Schizophr Res. 2007 Jan;89(1-3):198-210
17010573
Neuroimage. 2002 Oct;17(2):631-42
12377139
Schizophr Res. 1992 Jul;7(2):95-100
1355358
Biol Psychiatry. 2000 Jun 1;47(11):944-53
10838062
Am J Psychiatry. 1999 Aug;156(8):1190-9
10450259
Schizophr Res. 2005 Jun 15;75(2-3):265-81
15885518
J Cogn Neurosci. 2005 Nov;17(11):1774-84
16269113
Am J Psychiatry. 1998 Dec;155(12):1711-7
9842780
Psychiatry Res. 1999 Oct 11;91(3):155-62
10641579
Arch Gen Psychiatry. 2007 Apr;64(4):401-9
17404117
Epidemiol Psichiatr Soc. 2005 Oct-Dec;14(4):194-7
16396427
Can J Psychiatry. 1997 Feb;42(1):27-33
9040920
Schizophr Bull. 1990;16(3):425-32
1981107
Schizophr Res. 2001 Oct 1;52(1-2):87-99
11595395
Schizophr Res. 2006 Jul;85(1-3):245-53
16730162
Psychiatry Res. 2000 Dec 27;97(2-3):129-35
11166085
Biol Psychiatry. 1998 May 1;43(9):649-59
9582998
Psychiatry Res. 2001 Dec 30;108(3):161-8
11756014
Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9276-80
10908653
Psychiatry Res. 2000 May 15;98(3):155-62
10821998
Neuroimage. 2006 Aug 1;32(1):16-22
16626974
Am J Psychiatry. 1995 May;152(5):704-14
7726310
Schizophr Res. 2001 Mar 30;48(2-3):177-85
11295371
Biol Psychiatry. 1999 May 15;45(10):1329-35
10349040
Arch Gen Psychiatry. 1990 Nov;47(11):1023-8
2241504
Schizophr Res. 2005 Jul 15;76(2-3):173-85
15949650
Br J Gen Pract. 1991 Nov;41(352):468-71
1807308