title: [Localization and age relations of ocular aberrations].
abstract: BACKGROUND
  The aim of this study was to analyze the distribution of total, corneal, and mainly internal human third- to sixth-order aberrations (HOA) and investigate possible correlations between wavefront errors and patient age.
  
  
  METHODS
  For this study 140 eyes of 140 subjects (age range 17-77 years) were measured three times each using Nidek Optical Path Difference scan. Mean value and standard deviation for each Zernike polynomial was computed for a 5-mm pupil diameter, and six different age groups were formed.
  
  
  RESULTS
  There was wide individual variation in the internal wavefront aberrations. The mean root-mean-square value for HOA was 0.4563 microm+/-0.296 microm. No positive correlation was found between Zernike polynomials and increasing age. In total spherical aberration however a significant difference was found between the 26-35-year and > or =56-year age groups (p=0.0002), as well as to internal and total coma (Z8) (p=0.0487 and p=0.0117, respectively).
  
  
  CONCLUSIONS
  The internal, corneal, and total wavefront aberrations varied widely among patients. Some significant differences were found between the age groups. No correlation between age and the internal, corneal, or total aberrations was found.
authors.affiliation: International Vision Correction Research Centre (IVCRC), Universitäts-Augenklinik Heidelberg, Ruprecht-Karls Universität Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Deutschland.
authors.forename: S C
authors.initials: SC
authors.lastname: Goebels
authors.forename: G U
authors.initials: GU
authors.lastname: Auffarth
authors.forename: M P
authors.initials: MP
authors.lastname: Holzer
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D003315:Cornea / Q000503:physiopathology*; D019781:Corneal Topography; D005260:Female; D006801:Humans; D007908:Lens, Crystalline / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012029:Refraction, Ocular; D012030:Refractive Errors / Q000175:diagnosis* / Q000503:physiopathology; D018709:Statistics, Nonparametric
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