[Expression of proline-rich tyrosine kinase-2 in human primary colorectal carcinoma and its prognostic implication].
OBJECTIVE
To investigate the expression of proline-rich tyrosine kinase-2 (Pyk2) in human primary colorectal carcinoma (CRC) and it's prognostic significance.


METHODS
The expression of Pyk2 was retrospectively examined with immunohistochemistry (IHC) in 108 tissues of primary CRC. The correlation of Pyk2 expression to prognosis and relevant clinical factors were analyzed.


RESULTS
The rate of Pyk2 low-expression in CRC was 56.5% (61/108). The expression of Pyk2 correlated significantly to the histological grade (P < 0.05) and the TNM stage (P < 0.05), while no correlation between Pyk2 expression and age, tumor size (P > 0.05). Patients with Pyk2 over-expression had significantly higher 5-year survival rate (66.0%) than those with Pyk2 low-expression (31.4%). Pyk2 expression, together with carcinoma histologic grade and TNM stage were prognostic factors to CRC on the multivariate analysis.


CONCLUSIONS
Pyk2 expression can be a prognostic factor to the CRC patients together with other predictors.
Zhang
Zong-nai
ZN
Department of General Surgery, First Hospital, Peking University, Beijing 100034, China.
Wang
Xin
X
Li
Ting
T
Yin
Hong-fang
HF
Wan
Yuan-lian
YL
Liu
Yu-cun
YC
Zhu
Jing
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000473:pathology; D005260:Female; D051418:Focal Adhesion Kinase 2 / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis
D051418:Focal Adhesion Kinase 2