title: Evaluation of high-field asymmetric waveform ion mobility spectrometry mass spectrometry for the analysis of the mycotoxin zearalenone.
abstract: A high-field asymmetric waveform ion mobility spectrometry (FAIMS)-based method for the determination of the mycotoxin zearalenone (ZON) and its metabolites alpha-zearalenol (alpha-ZOL), beta-zearalenol (beta-ZOL), and beta-zearalanol (beta-ZAL), in a cornmeal (maize) matrix is described. Detection limits achieved using the FAIMS device coupled with electrospray ionization (ESI) and mass spectrometric (MS) detection are 0.4 ng mL(-1) for ZON and 3 ng mL(-1) for alpha-ZOL+beta-ZOL, and beta-ZAL. This represents a significant improvement when compared to detection limits determined using ESI-MS or ESI-tandem mass spectrometry (MSMS) analytical methods. The developed flow-injection (FIA)-ESI-FAIMS-MS method was applied to reference materials ERM-BC-716 and ERM-BC-717 certified for ZON and excellent agreement with the certified values was observed.
authors.affiliation: Institute for National Measurement Standards, National Research Council Canada, 1200 Montreal Road, Ottawa, ON, Canada.
authors.forename: Margaret
authors.initials: M
authors.lastname: McCooeye
authors.forename: Beata
authors.initials: B
authors.lastname: Kolakowski
authors.forename: Joe
authors.initials: J
authors.lastname: Boison
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Mester
mesh_terms: D053000:Analytic Sample Preparation Methods; D013058:Mass Spectrometry / Q000379:methods*; D009183:Mycotoxins / Q000032:analysis*; D012015:Reference Standards; D012680:Sensitivity and Specificity; D021241:Spectrometry, Mass, Electrospray Ionization; D013997:Time Factors; D003313:Zea mays / Q000737:chemistry; D015025:Zearalenone / Q000032:analysis*
chemical_list: D009183:Mycotoxins; D015025:Zearalenone