title: [Efficacy of antimicrobial prophylaxis in neurosurgical operations].
abstract: OBJECTIVE
  It is reported that antimicrobial prophylaxis (AMP) reduces the incidence of surgical site infection (SSI) in neurological surgery. However, a great deal of variation exists regarding the type of antibiotics, dose, timing and duration. In this study, the authors analyzed the incidence of SSI comparing two different AMP protocols.
  
  
  METHODS
  Five hundred and fifty patients who had undergone neurosurgeries at our institute between April 2005 and August 2007 were reviewed retrospectively. They were divided into the protocol F (309 patients with two or more days AMP) and the protocol P (241 patients with one-day AMP).
  
  
  RESULTS
  Baseline characteristics were not statistically different between two protocols. The overall rate of SSI was 1.5%. Although SSI showed a trend of low SSI incidence in the protocol P (0.8%), this was not statistically significant compared with that in the protocol F (1.9%).
  
  
  CONCLUSIONS
  The one-day (< 24 hours) administration of AMP is enough to prevent SSI in neurological surgery.
authors.affiliation: Department of Neurosurgery, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Morofuji
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Ishizaka
authors.forename: Tomonori
authors.initials: T
authors.lastname: Takeshita
authors.forename: Keisuke
authors.initials: K
authors.lastname: Toyoda
authors.forename: Kenta
authors.initials: K
authors.lastname: Ujifuku
authors.forename: Makoto
authors.initials: M
authors.lastname: Hirose
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Izumo
authors.forename: Keishi
authors.initials: K
authors.lastname: Tsunoda
authors.forename: Kentaro
authors.initials: K
authors.lastname: Hayashi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Matsuo
authors.forename: Naoki
authors.initials: N
authors.lastname: Kitagawa
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Suyama
authors.forename: Izumi
authors.initials: I
authors.lastname: Nagata
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D019072:Antibiotic Prophylaxis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D019990:Perioperative Care; D017410:Practice Guidelines as Topic; D012189:Retrospective Studies; D013530:Surgical Wound Infection / Q000517:prevention & control*; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents