Carbamazepine-induced drug-induced hypersensitivity syndrome in a 14-year-old Japanese boy.
Drug-induced hypersensitivity syndrome (DIHS) is a life-threatening idiosyncratic drug reaction, and an early accurate diagnosis is essential for its treatment. We describe a 14-year-old boy with localization-related epilepsy, who developed severe adverse cutaneous and systemic reactions after 3 weeks of carbamazepine administration. During the course of the clinical symptoms, reactivation of human herpesvirus 6 (HHV-6) was proven by detection of the HHV-6 genome in serum and elevation of HHV-6 immunoglobulin G (IgG). He fulfilled the newly established criteria for DIHS. Among eight identified medications that can precipitate DIHS, four are antiepileptic drugs. Establishing a treatment strategy for DIHS is warranted to improve its outcome. Therefore, it is important to raise awareness of DIHS among epileptologists.
Suzuki
Yuka
Y
Department of Pediatrics, Ehime University Graduate School of Medicine, Toon, Ehime, Japan. yusuzuki@m.ehime-u.ac.jp
Fukuda
Mitsumasa
M
Tohyama
Mikiko
M
Ishikawa
Manami
M
Yasukawa
Masaki
M
Ishii
Eiichi
E
D000293:Adolescent; D000927:Anticonvulsants / Q000009:adverse effects*; D002220:Carbamazepine / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology*; D004827:Epilepsy / Q000188:drug therapy; D004890:Erythema / Q000139:chemically induced; D015654:Herpesvirus 6, Human / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D008297:Male; D019349:Roseolovirus Infections / Q000150:complications
D000927:Anticonvulsants; D002220:Carbamazepine