title: [Infectious bursal disease: distribution and persistence of the virus in inoculated chickens. Study on the transmission of the disease].
abstract: The distribution, concentration and persistence of infectious bursal disease virus (IBDV) in the lymphoid organs of inoculated chickens, and its persistence in contaminated premises was examined. The virus only multiplied in the bursa of Fabricius where it induced degeneration and necrosis of the lymphoid cells. It persisted for 10 days in this organ and the highest viral concentrations were observed between the 4th and 8th day following inoculation. The virus was found at a low concentration in the spleen and thymus only during the viraemia phase. The inoculated chickens shed virus in the excreta during the first days of infection. The disease was transmitted to other chickens by direct contact with birds which had been inoculated 4, 10 and 14 days previously with IBDV. Litter on which infected chickens had been reared had a high level of infectivity for 30 days after removal from the chickens and still had some infectivity after 60 days. The long life of the virus in an infected house explains its persistence on infected farms and its transmission to successive flocks.
authors.affiliation: Faculté de Médecine vétérinaire de l'Université de Liège, Bruxelles, Belgium.
authors.forename: H
authors.initials: H
authors.lastname: Vindevogel
authors.forename: M
authors.initials: M
authors.lastname: Gouffaux
authors.forename: G
authors.initials: G
authors.lastname: Meulemans
authors.forename: J P
authors.initials: JP
authors.lastname: Duchatel
authors.forename: P
authors.initials: P
authors.lastname: Halen