title: The role of dopamine and serotonin in suicidal behaviour and aggression.
abstract: Serotonin and dopamine are two monoamines which are known to interact with each other. Their role for suicidal behaviour, aggression and mood are reviewed in this chapter. We found a substantial amount of evidence for the relevance of a serotonin and dopamine model of aggression, and for aggression as a major risk factor for suicide. Evidence was found that serotonin and dopamine also may be involved in depressed mood, and possibly the individual's ability to cope with imminent suicidality.
authors.affiliation: Department of Clinical Neurophysiology, Karolinska Hospital, Huddinge, SE 141 52 Stockholm, Sweden. erik.ryding@karolinska.se
authors.forename: Erik
authors.initials: E
authors.lastname: Ryding
authors.forename: Mats
authors.initials: M
authors.lastname: Lindström
authors.forename: Lil
authors.initials: L
authors.lastname: Träskman-Bendz
mesh_terms: D000374:Aggression; D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism; D003863:Depression / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D012307:Risk Factors; D012701:Serotonin / Q000378:metabolism*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D013405:Suicide
chemical_list: D004298:Dopamine; D012701:Serotonin; D050486:Serotonin Plasma Membrane Transport Proteins; D017367:Selective Serotonin Reuptake Inhibitors