Efficient iron-catalyzed N-arylation of aryl halides with amines.
A practical and promising protocol was developed for N-arylations of various amines with differently substituted aryl halides. The processes are efficiently promoted by the catalyst system involving the environmentally benign Fe2O3 and the universal ligand L-proline. The versatility, convenient operation, low cost, and environmental friendliness, in combination with the high yields, render this method viable for use in both laboratory research and larger industrial scales.
Guo
Diliang
D
Drug Discovery and Design Centre, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
Huang
He
H
Xu
Jinyi
J
Jiang
Hualiang
H
Liu
Hong
H
D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D006219:Halogens / Q000737:chemistry*; D007501:Iron / Q000737:chemistry*; D015394:Molecular Structure
D000588:Amines; D006219:Halogens; D007501:Iron