Inhibitors targeting two-component signal transduction.
A two-component signal transduction system (TCS) is an attractive target for antibacterial agents. In this chapter, we review the TCS inhibitors developed during the past decade and introduce novel drug discovery systems to isolate the inhibitors of the YycG/YycF system, an essential TCS for bacterial growth, in an effort to develop a new class of antibacterial agents.
Watanabe
Takafumi
T
Department of Bioscience, Graduate School of Agriculture, Kinki University, 3327-204 Nakamachi, Nara 631-8505, Japan.
Okada
Ario
A
Gotoh
Yasuhiro
Y
Utsumi
Ryutaro
R
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000235:genetics; D018407:Bacterial Physiological Phenomena / Q000187:drug effects; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology; D015195:Drug Design; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics / Q000502:physiology; D000071677:Histidine Kinase; D008826:Microbial Sensitivity Tests; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D011494:Protein Kinases / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D014584:User-Computer Interface
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D047428:Protein Kinase Inhibitors; C119939:YycF protein, Bacteria; D011494:Protein Kinases; D000071677:Histidine Kinase