Nucleic acid duplexes with zippers of additional nucleobases and aromatics in minor or major groove.
Two series of thymidine derivatives with additional nucleobases/aromatics attached to either the 5'(S)-C- or the 5-position were prepared by epoxide opening and/or "click chemistry" cycloaddition protocols and introduced into DNA duplexes. Interstrand base-base communication in the minor groove and intrastrand stacking interactions in the major groove were detected.
Nielsen
Poul
P
Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, 5230 Odense M, Denmark. pon@ifk.sdu.dk
Shaikh
Khalil I
KI
Nielsen
Lise J
LJ
Andersen
Nicolai K
NK
Spácilová
Lucie
L
Nielsen
Henrik
H
Kocalka
Petr
P
Christensen
Mikkel S
MS
D004247:DNA / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis / Q000737:chemistry; D013696:Temperature; D013936:Thymidine / Q000031:analogs & derivatives*; D014230:Triazoles / Q000737:chemistry
D011741:Pyrimidine Nucleosides; D014230:Triazoles; D004247:DNA; D013936:Thymidine