title: Levels of angiogenic factors in pregnancy and post-partum bleeding.
abstract: We have studied if serum levels of soluble fms-like tyrosine kinase-1 (sFlt-1) and placenta growth factor (PlGF) in pregnancy could predict excess post-partum bleeding. In 392 normotensive singleton pregnancies, concentrations of sFlt-1 and PlGF in the first, second, and third trimester were compared between women with and without excess post-partum bleeding, defined as blood loss volume of at least 500 mL. Mean concentrations of sFlt-1 were consistently higher in all three trimesters among women who had excess post-partum bleeding compared to women without this, but significantly higher only in the second trimester. For PlGF, there were no significant differences between the groups. High concentrations of the anti-angiogenic factor sFlt-1 in maternal circulation during pregnancy may be associated with an increased risk of excess post-partum bleeding.
authors.affiliation: Department of Obstetrics and Gynecology, Akershus University Hospital and the Faculty of Medicine, University of Oslo, Norway. anne.eskild@medisin.uio.no
authors.forename: Anne
authors.initials: A
authors.lastname: Eskild
authors.forename: Stig
authors.initials: S
authors.lastname: Jeansson
authors.forename: Pål A
authors.initials: PA
authors.lastname: Jenum
authors.forename: Anne C
authors.initials: AC
authors.lastname: Staff
authors.forename: Ravi
authors.initials: R
authors.lastname: Thadhani
authors.forename: Ananth
authors.initials: A
authors.lastname: Karumanchi
authors.forename: Lars J
authors.initials: LJ
authors.lastname: Vatten
mesh_terms: D016022:Case-Control Studies; D005260:Female; D006801:Humans; D000072483:Placenta Growth Factor; D006473:Postpartum Hemorrhage / Q000097:blood*; D011247:Pregnancy / Q000097:blood*; D011257:Pregnancy Proteins / Q000097:blood*; D018709:Statistics, Nonparametric; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood*
chemical_list: C000608036:PGF protein, human; D011257:Pregnancy Proteins; D000072483:Placenta Growth Factor; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1