title: The combined effect of norepinephrine transporter gene and negative life events in major depression of Chinese Han population.
abstract: The aim of the present study was to detect the combined effect of negative life events and the norepinephrine transporter (NET) gene on the development of major depression (MD) in a Chinese population. We recruited 388 unrelated patients affected with MD and 388 healthy controls in this study. The score of 32 was used as a cut-off value for grouping the negative life events into the severe and moderate forms using the Life Events Scale (LES). SNPs including rs2242446 and rs5569 of the NET gene were genotyped. The chi-square (chi (2)) test showed allelic association for the T-182C polymorphism (chi (2) = 6.46, corrected P = 0.011) and also showed genotypic association (chi (2) = 6.87, corrected P = 0.034). Multifactor dimensionality reduction (MDR) showed that the interaction between the rs2242446-rs5569 combination and negative life events had a CV consistency of 10 and PE of 0.3487. Compared with those having both T-G-MN combination used as reference group, we found that the OR scaled up from 1 to 7.39 (95%CI 3.40-16.06) in the C-A-SN group. The present study suggests that the combined effect of rs2242446 and rs5569 in the NET gene could modify the response to the negative life events in triggering MD.
authors.affiliation: Department of Psychiatry, First Hospital of Shanxi Medical University, 030001, Taiyuan, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Sun
authors.forename: Yong
authors.initials: Y
authors.lastname: Xu
authors.forename: Yanfang
authors.initials: Y
authors.lastname: Wang
authors.forename: Huijun
authors.initials: H
authors.lastname: Duan
authors.forename: Shan
authors.initials: S
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Ren
authors.forename: Juyi
authors.initials: J
authors.lastname: Peng
authors.forename: Qiaorong
authors.initials: Q
authors.lastname: Du
authors.forename: Yan
authors.initials: Y
authors.lastname: Shen
authors.forename: Qi
authors.initials: Q
authors.lastname: Xu
authors.forename: Kerang
authors.initials: K
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D001923:Brain Chemistry / Q000235:genetics*; D004252:DNA Mutational Analysis; D003865:Major Depressive Disorder / Q000208:ethnology / Q000235:genetics* / Q000523:psychology; D004777:Environment; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000378:metabolism*; D050484:Norepinephrine Plasma Membrane Transport Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics; D055815:Young Adult
chemical_list: D050484:Norepinephrine Plasma Membrane Transport Proteins; D009638:Norepinephrine
references.citation: J Psychiatry Neurosci. 2007 Mar;32(2):121-8
references.pmid: 17353941
references.citation: Mol Psychiatry. 2005 Feb;10(2):220-4
references.pmid: 15263905
references.citation: Depress Anxiety. 1996-1997;4(4):153-9
references.pmid: 9166647
references.citation: Science. 2003 Jul 18;301(5631):386-9
references.pmid: 12869766
references.citation: Am J Psychiatry. 1999 Jun;156(6):837-41
references.pmid: 10360120
references.citation: J Consult Clin Psychol. 2004 Jun;72(3):511-22
references.pmid: 15279534
references.citation: Arch Gen Psychiatry. 1994 May;51(5):411-22
references.pmid: 8179465
references.citation: Annu Rev Clin Psychol. 2007;3:137-58
references.pmid: 17716051
references.citation: J Nerv Ment Dis. 1998 Nov;186(11):661-9
references.pmid: 9824167
references.citation: Biol Psychiatry. 2004 Aug 15;56(4):292-5
references.pmid: 15312818
references.citation: Acta Psychiatr Scand Suppl. 2003;(418):61-6
references.pmid: 12956817
references.citation: Neuropsychobiology. 2004;49(4):174-7
references.pmid: 15118352
references.citation: J Affect Disord. 2004 Oct 1;82(1):119-23
references.pmid: 15465584
references.citation: Mol Psychiatry. 2002;7(1):118-22
references.pmid: 11803458
references.citation: Am J Psychiatry. 1981 Jan;138(1):1-13
references.pmid: 7446757
references.citation: Science. 2002 Aug 2;297(5582):851-4
references.pmid: 12161658
references.citation: Brain Res Bull. 2001 Nov 15;56(5):487-94
references.pmid: 11750794
references.citation: J Gerontol B Psychol Sci Soc Sci. 2002 Jan;57(1):P87-94
references.pmid: 11773227
references.citation: Biochem Biophys Res Commun. 1995 Oct 24;215(3):1145-50
references.pmid: 7488042
references.citation: Int J Neuropsychopharmacol. 2007 Aug;10(4):437-47
references.pmid: 16756688
references.citation: Biol Psychiatry. 2004 Apr 1;55(7):733-8
references.pmid: 15039002
references.citation: Neuropsychobiology. 2004;50(4):301-4
references.pmid: 15539861
references.citation: J Child Psychol Psychiatry. 2003 Oct;44(7):977-87
references.pmid: 14531580
references.citation: Dtsch Med Wochenschr. 2006 Jan 5;131(1-2):35-40
references.pmid: 16374742
references.citation: Psychiatry Res. 1999 Jul 30;87(1):1-5
references.pmid: 10512149
references.citation: Biol Psychiatry. 2006 Jul 15;60(2):84-92
references.pmid: 16300747
references.citation: Br J Psychiatry. 2001 Oct;179:308-16
references.pmid: 11581110
references.citation: J Clin Psychiatry. 1998;59 Suppl 14:11-4
references.pmid: 9818625
references.citation: Br J Psychiatry. 2006 Mar;188:210-5
references.pmid: 16507960
references.citation: Neuropsychopharmacology. 2002 Apr;26(4):489-93
references.pmid: 11927173
references.citation: Control Clin Trials. 1998 Dec;19(6):589-601
references.pmid: 9875838
references.citation: Arch Gen Psychiatry. 2005 May;62(5):529-35
references.pmid: 15867106
references.citation: Depress Anxiety. 2003;17(1):26-33
references.pmid: 12577275
references.citation: Genet Epidemiol. 2003 Sep;25(2):115-21
references.pmid: 12916020