title: Neuroleptic malignant syndrome without fever after addition of oxcarbazepine to long-term treatment with amisulpride.
abstract: OBJECTIVE
  Our goal was to report a case of malignant neuroleptic syndrome in a patient administered with both oxcarbazepine (OXCBZ) and amisulpride (AM).
  
  
  METHODS
  We present a case of a young man who presented with symptoms of malignant neuroleptic syndrome after progressive titration of OXCBZ (1,200 mg) added to the long-term treatment with AM (800 mg).
  
  
  RESULTS
  After discontinuation of AM and administration of dopaminergic drugs, his clinical symptoms improved gradually.
  
  
  CONCLUSIONS
  This case suggests that clinicians should consider the risk of neuroleptic malignant syndrome when OXCBZ is coadministered to patients undergoing long-term treatment with neuroleptics.
authors.affiliation: General Hospital of Thessaloniki, Greece. petrosangelopoulos@yahoo.gr
authors.forename: Petros
authors.initials: P
authors.lastname: Angelopoulos
authors.forename: Maria
authors.initials: M
authors.lastname: Markopoulou
authors.forename: Kyriakos
authors.initials: K
authors.lastname: Kyamidis
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Bobotas
mesh_terms: D000328:Adult; D000077582:Amisulpride; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002220:Carbamazepine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D009459:Neuroleptic Malignant Syndrome / Q000175:diagnosis / Q000209:etiology*; D000078330:Oxcarbazepine; D012559:Schizophrenia / Q000188:drug therapy*; D013469:Sulpiride / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D014150:Antipsychotic Agents; D002220:Carbamazepine; D013469:Sulpiride; D000077582:Amisulpride; D000078330:Oxcarbazepine