title: [Screening of risk groups for discovering intracranial aneurysms before rupture].
abstract: In development of intracranial aneurysms contribute genetic factors together with smoking, hypertension, diabetes mellitus. Epidemiology studies suggest that as many as 5% of people harbour a cerebral aneurysm by age 75. Rupture of cerebral aneurysm is the most frequent cause of spontaneous subarachnoid haemorrhage (up to 80%.) Annual incidence of SAH is 10-14/100 000, but only 15-20% of aneurysms will rupture, and that will happen probably between 40-60 years. The morbidity and mortality of aneurismal subarachnoid (SAH) continues to be high. It is not possible to predict who has aneurysm and is it going to bleed or not, but it is possible to reveal high risk groups (polycystic kidney disease, Ehlers-Danlos sy, Marphan sy, family history of cerebral aneurysms, suspect de novo aneurysm formation in patients with prior history of cerebral aneurysm). Reviewing data from literature and reporting cases from each group with high risk, that have been screened and aneurysms discovered, authors wish to focus interest on this matter and propose screening program for these groups of patients. The mortality and morbidity in cases treated before rupture is significantly lower than after SAH, so screening programs could save many lives. According to our preliminara data, mostly based on control angiographies after 8-10 zears in patients previouslz operated for intracranial aneurysmas, from 15 angipgraphies 4 revealed new aneurysms (26% in 10 years period) with total number of 6 de novo formed aneurysms, which is not valid due to small number of patients but strongly suggests the importancy of screening program for risk groups.
authors.affiliation: Institut za neurohirurgiju KCS, Beograd.
authors.forename: Lj B
authors.initials: LjB
authors.lastname: Vujotić
authors.forename: M Lj
authors.initials: MLj
authors.lastname: Rakić
authors.forename: D V
authors.initials: DV
authors.lastname: Radulović
authors.forename: E E
authors.initials: EE
authors.lastname: Slavik
authors.forename: L R
authors.initials: LR
authors.lastname: Danilović
authors.forename: B D
authors.initials: BD
authors.lastname: Nestorović
authors.forename: L G
authors.initials: LG
authors.lastname: Rasulić
authors.forename: V T
authors.initials: VT
authors.lastname: Jovanović
mesh_terms: D000328:Adult; D017542:Aneurysm, Ruptured / Q000150:complications / Q000175:diagnosis; D002533:Cerebral Angiography; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications / Q000175:diagnosis*; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013345:Subarachnoid Hemorrhage / Q000209:etiology*