Effects of a cyclooxygenase 2 inhibitor on fracture healing in a rat model.
Since the advent of cyclooxygenase 2 (COX-2) inhibitors, little research has been done on the effects of these medications on fracture healing. In the study reported here, we sought to determine whether a COX-2 inhibitor, celecoxib, affects strength and amount of healing callus formed after a fracture. Forty-eight male Sprague-Dawley rats were evaluated for impairment of fracture healing with celecoxib use. Compared with controls, celecoxib-treated rats had a significant decrease in force required for refracture (P = .0199). We do not recommend routine use of celecoxib in postfracture pain control, particularly when fracture union is tenuous.
Herbenick
Michael A
MA
Department of Orthopaedic Surgery, Wright State University School of Medicine, Dayton, OH 45409, USA. maherbenick@mvh.org
Sprott
Dominic
D
Stills
Harold
H
Lawless
Matthew
M
D000818:Animals; D000068579:Celecoxib; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D004195:Disease Models, Animal; D017102:Fracture Healing / Q000187:drug effects*; D008297:Male; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013449:Sulfonamides / Q000494:pharmacology*
D016861:Cyclooxygenase Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides; D000068579:Celecoxib