title: Urinary metabolite concentrations of organophosphorous pesticides, bisphenol A, and phthalates among pregnant women in Rotterdam, the Netherlands: the Generation R study.
abstract: Concern about potential health impacts of low-level exposures to organophosphorus (OP) pesticides, bisphenol A (BPA), and phthalates among the general population is increasing. We measured levels of six dialkyl phosphate (DAP) metabolites of OP pesticides, a chlorpyrifos-specific metabolite (3,5,6-trichloro-2-pyridinol, TCPy), BPA, and 14 phthalate metabolites in urine samples of 100 pregnant women from the Generation R study, the Netherlands. The unadjusted and creatinine-adjusted concentrations were reported, and compared to National Health and Nutrition Examination Survey and other studies. In general, these metabolites were detectable in the urine of the women from the Generation R study and compared with other groups, they had relatively high-level exposures to OP pesticides and several phthalates but similar exposure to BPA. The median concentrations of total dimethyl (DM) metabolites was 264.0 n mol/g creatinine (Cr) and of total DAP was 316.0 n mol/g Cr. The median concentration of mono-ethyl phthalate (MEP) was 222.0 microg/g Cr; the median concentrations of mono-isobutyl phthalate (MiBP) and mono-n-butyl phthalate (MnBP) were above 50 microg/g Cr. The median concentrations of the three secondary metabolites of di-2-ethylhexyl phthalate (DEHP) were greater than 20 microg/g Cr. The data indicate that the Generation R study population provides a wide distribution of selected environmental exposures. Reasons for the relatively high levels and possible health effects need investigation.
authors.affiliation: Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, MD A3-05, PO Box 12233, Research Triangle Park, NC 27709, USA.
authors.forename: Xibiao
authors.initials: X
authors.lastname: Ye
authors.forename: Frank H
authors.initials: FH
authors.lastname: Pierik
authors.forename: Russ
authors.initials: R
authors.lastname: Hauser
authors.forename: Susan
authors.initials: S
authors.lastname: Duty
authors.forename: Jürgen
authors.initials: J
authors.lastname: Angerer
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Park
authors.forename: Alex
authors.initials: A
authors.lastname: Burdorf
authors.forename: Albert
authors.initials: A
authors.lastname: Hofman
authors.forename: Vincent W V
authors.initials: VW
authors.lastname: Jaddoe
authors.forename: Johan P
authors.initials: JP
authors.lastname: Mackenbach
authors.forename: Eric A P
authors.initials: EA
authors.lastname: Steegers
authors.forename: Henning
authors.initials: H
authors.lastname: Tiemeier
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Longnecker
mesh_terms: D000293:Adolescent; D000328:Adult; D001559:Benzhydryl Compounds; D002947:Cities; D015331:Cohort Studies; D004784:Environmental Monitoring / Q000379:methods*; D004785:Environmental Pollutants / Q000378:metabolism / Q000652:urine; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D005865:Gestational Age; D006801:Humans; D018811:Maternal Exposure; D009426:Netherlands; D009943:Organophosphorus Compounds / Q000378:metabolism / Q000652:urine; D010575:Pesticides / Q000378:metabolism / Q000652:urine; D010636:Phenols / Q000378:metabolism / Q000652:urine; D010795:Phthalic Acids / Q000378:metabolism / Q000652:urine; D011247:Pregnancy; D053719:Tandem Mass Spectrometry; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004785:Environmental Pollutants; D009943:Organophosphorus Compounds; D010575:Pesticides; D010636:Phenols; D010795:Phthalic Acids; C006780:bisphenol A; D000098826:Bisphenol A Compounds
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