title: Physicochemical stability of NOX-E36, a 40mer L-RNA (Spiegelmer) for therapeutic applications.
abstract: Spiegelmers are structured mirror-image oligonucleotides that are designed to bind and inhibit pharmacologically relevant target molecules. The synthesis and purification of mirror-image oligonucleotides is comparable to the manufacturing of standard oligonucleotides that consist of naturally configured nucleotides. Due to the use of the non-natural L-nucleotides in Spiegelmers, these oligonucleotides show an exceptional biostability. Further, they also display a high physicochemical stability in solution. These properties make them interesting substances for drug development.
authors.affiliation: NOXXON Pharma AG, Max-Dohrn-Strasse 8-10, D-10589 Berlin, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Maasch
authors.forename: Klaus
authors.initials: K
authors.lastname: Buchner
authors.forename: Dirk
authors.initials: D
authors.lastname: Eulberg
authors.forename: Stefan
authors.initials: S
authors.lastname: Vonhoff
authors.forename: Sven
authors.initials: S
authors.lastname: Klussmann
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D002460:Cell Line; D018932:Chemokine CCL2 / Q000037:antagonists & inhibitors*; D002633:Chemotaxis / Q000187:drug effects; D006801:Humans; D007249:Inflammation / Q000188:drug therapy
chemical_list: D052157:Aptamers, Nucleotide; C111835:CCL2 protein, human; D018932:Chemokine CCL2; C541611:NOX-E36 aptamer