title: IL27: its roles in the induction and inhibition of inflammation.
abstract: IL27 is the newest member of the IL6/IL12 family. It consists of Epstein-Barr virus-induced gene 3 (EBI3) and p28 subunits and signals through the IL27 receptor complex formed by WSX-1 and gp130 subunits. IL27-IL27 receptor interaction was initially shown to induce an early signal for the induction of Th1 responses. Recently other studies indicate that IL27 inhibits inflammatory Th17 lineage development. Despite the overall effects observed, the role of individual IL27 subunits remains controversial and is largely unclear. EBI3, while predominately found with p28 to form IL27, has different expression kinetics than p28. P28 has also been shown to signal independently of EBI3. Moreover, EBI3 has other potential binding partners such as the p35 subunit of IL12 and theoretically may regulate the inflammatory response through yet undiscovered mechanisms. Understanding the inflammatory and anti-inflammatory roles of IL27 and its subunits are essential before the immunological regulatory therapies can be developed.
authors.affiliation: Department of Pathology and Comprehensive Cancer Center, The Ohio State University Medical Center Columbus, OH, USA.
authors.forename: Joseph W
authors.initials: JW
authors.lastname: Carl
authors.forename: Xue-Feng
authors.initials: XF
authors.lastname: Bai
references.citation: Eur J Biochem. 2001 Jan;268(1):160-7
references.pmid: 11121117
references.citation: Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15047-52
references.pmid: 14657353
references.citation: J Immunol. 2004 Nov 1;173(9):5626-34
references.pmid: 15494513
references.citation: Immunity. 2006 Jun;24(6):677-688
references.pmid: 16782025
references.citation: J Exp Med. 2005 Jan 17;201(2):233-40
references.pmid: 15657292
references.citation: J Immunol. 2004 Jun 15;172(12):7635-41
references.pmid: 15187144
references.citation: J Exp Med. 2006 Aug 7;203(8):1875-81
references.pmid: 16880260
references.citation: Int Immunol. 2005 May;17(5):649-59
references.pmid: 15837713
references.citation: Nature. 2000 Oct 19;407(6806):916-20
references.pmid: 11057672
references.citation: J Immunol. 2004 Dec 15;173(12):7490-6
references.pmid: 15585875
references.citation: Am J Pathol. 2005 Apr;166(4):1217-28
references.pmid: 15793300
references.citation: Annu Rev Immunol. 2007;25:221-42
references.pmid: 17291186
references.citation: Immunity. 2002 Jun;16(6):779-90
references.pmid: 12121660
references.citation: Nature. 2006 May 11;441(7090):235-8
references.pmid: 16648838
references.citation: J Hum Genet. 2007;52(4):355-361
references.pmid: 17318299
references.citation: J Immunol. 2004 Aug 15;173(4):2479-85
references.pmid: 15294962
references.citation: J Immunol. 2005 Aug 1;175(3):1686-93
references.pmid: 16034109
references.citation: Nat Immunol. 2006 Sep;7(9):929-36
references.pmid: 16906167
references.citation: Int Immunol. 2007 Jan;19(1):93-8
references.pmid: 17118967
references.citation: Mol Immunol. 2007 Mar;44(7):1808-14
references.pmid: 17046061
references.citation: Immunity. 2000 Nov;13(5):715-25
references.pmid: 11114383
references.citation: J Immunol. 2002 Dec 15;169(12):7104-10
references.pmid: 12471147
references.citation: J Pathol. 2004 Feb;202(2):164-71
references.pmid: 14743498
references.citation: Nat Immunol. 2006 Sep;7(9):937-45
references.pmid: 16906166
references.citation: Nature. 2003 Feb 13;421(6924):744-8
references.pmid: 12610626
references.citation: Biochem Biophys Res Commun. 1998 May 8;246(1):82-90
references.pmid: 9600072
references.citation: Immunobiology. 2006;211(6-8):427-36
references.pmid: 16920482
references.citation: J Immunol. 2005 Aug 15;175(4):2191-200
references.pmid: 16081786
references.citation: Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16951-6
references.pmid: 12482940
references.citation: J Immunol. 2004 Nov 15;173(10):6465-71
references.pmid: 15528388
references.citation: Annu Rev Immunol. 2005;23:1-21
references.pmid: 15771564
references.citation: J Neurol Sci. 2005 May 15;232(1-2):3-9
references.pmid: 15850576
references.citation: J Immunol. 2004 Jul 15;173(2):1171-8
references.pmid: 15240707
references.citation: Am J Pathol. 2006 Jan;168(1):158-69
references.pmid: 16400019
references.citation: Trends Immunol. 2006 Jan;27(1):17-23
references.pmid: 16290228
references.citation: J Pathol. 2006 Jul;209(3):360-8
references.pmid: 16639698
references.citation: Biochem Biophys Res Commun. 2005 Jan 28;326(4):724-8
references.pmid: 15607729
references.citation: Nat Immunol. 2006 Sep;7(9):899-901
references.pmid: 16924249
references.citation: J Immunol. 2005 Aug 15;175(4):2401-7
references.pmid: 16081811
references.citation: J Exp Med. 2007 Jan 22;204(1):141-52
references.pmid: 17227910
references.citation: J Immunol. 2005 Jun 15;174(12):7684-91
references.pmid: 15944269
references.citation: J Interferon Cytokine Res. 2003 Sep;23(9):513-22
references.pmid: 14565860
references.citation: Med Microbiol Immunol. 2004 Feb;193(1):1-17
references.pmid: 12836019
references.citation: J Virol. 1996 Feb;70(2):1143-53
references.pmid: 8551575
references.citation: Mol Endocrinol. 2005 Aug;19(8):2047-59
references.pmid: 15860546
references.citation: Annu Rev Immunol. 1997;15:797-819
references.pmid: 9143707
references.citation: Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):12041-6
references.pmid: 9342359
references.citation: J Med Virol. 2004 Jul;73(3):432-8
references.pmid: 15170639
references.citation: J Immunol. 2006 May 15;176(10):5890-7
references.pmid: 16670296
references.citation: J Immunol. 2003 May 15;170(10):4886-90
references.pmid: 12734330
references.citation: J Immunol. 2004 Feb 15;172(4):2225-31
references.pmid: 14764690
references.citation: Immunity. 2001 Oct;15(4):569-78
references.pmid: 11672539
references.citation: Nat Rev Immunol. 2005 Jul;5(7):521-31
references.pmid: 15999093
references.citation: Biochem J. 1994 Jun 1;300 ( Pt 2):281-90
references.pmid: 8002928
references.citation: Cell. 2006 Sep 22;126(6):1121-33
references.pmid: 16990136