title: Sustained elevated levels of circulating vasopressin selectively stimulate the proliferation of kidney tubular cells via the activation of V2 receptors.
abstract: The hypothalamic hormone vasopressin (AVP) has known mitogenic effects on various cell types. This study was designed to determine whether sustained elevated levels of circulating AVP could influence cell proliferation within adult tissues known to express different AVP receptors, including the pituitary, adrenal gland, liver, and kidney. Plasmatic AVP was chronically increased by submitting animals to prolonged hyperosmotic stimulation or implanting them with a AVP-containing osmotic minipump. After several days of either treatment, increased cell proliferation was detected only within the kidney. This kidney cell proliferation was not affected by the administration of selective V1a or V1b receptor antagonists but was either inhibited or mimicked by the administration of a selective V2 receptor antagonist or agonist, respectively. Kidney proliferative cells mostly concerned a subpopulation of differentiated tubular cells known to express the V2 receptors and were associated with the phosphorylation of ERK. These data indicate that in the adult rat, sustained elevated levels of circulating AVP stimulates the proliferation of a subpopulation of kidney tubular cells expressing the V2 receptor, providing the first illustration of a mitogenic effect of AVP via the activation of the V2 receptor subtype.
authors.affiliation: Départements d'Endocrinologie, Institut de Génomique Fonctionnelle, 141 Rue de la Cardonille, 34094 Montpellier cedex 05, France.
authors.forename: Gérard
authors.initials: G
authors.lastname: Alonso
authors.forename: Evelyne
authors.initials: E
authors.lastname: Galibert
authors.forename: Véra
authors.initials: V
authors.lastname: Boulay
authors.forename: Anne
authors.initials: A
authors.lastname: Guillou
authors.forename: Alexandra
authors.initials: A
authors.lastname: Jean
authors.forename: Valérie
authors.initials: V
authors.lastname: Compan
authors.forename: Gilles
authors.initials: G
authors.lastname: Guillon
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology; D007684:Kidney Tubules / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009994:Osmolar Concentration; D051381:Rats; D017207:Rats, Sprague-Dawley; D017483:Receptors, Vasopressin / Q000502:physiology*; D012965:Sodium Chloride / Q000494:pharmacology
chemical_list: D017483:Receptors, Vasopressin; D001127:Arginine Vasopressin; D012965:Sodium Chloride; D003894:Deamino Arginine Vasopressin