title: Suppressor of cytokine signaling-1 reduces high glucose-induced TGF-beta1 and fibronectin synthesis in human mesangial cells.
abstract: Janus kinase (JAK) signal transducers, and activators of transcription (STAT), contribute to diabetic nephropathy. Here we show that one of the suppressors of cytokine signaling (SOCS) proteins, SOCS-1, was upregulated in human mesangial cells (HMCs) under high glucose conditions, along with the activation of JAK2, STAT1, and STAT3. Overexpression of SOCS-1 in HMCs inhibited HG-induced JAK2/STAT activation, c-Fos/c-Jun expression, and increased synthesis of TGF-beta1 and fibronectin. These data suggest that SOCS-1 inhibits HG-induced overexpression of TGF-beta1 and synthesis of fibronectin in HMC, which may be via JAK/STAT pathway.
authors.affiliation: Department of Pathology, Hebei Medical University, No. 361 East Zhongshan Road, Shijiazhuang, Hebei 050017, China.
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Shi
authors.forename: Yanling
authors.initials: Y
authors.lastname: Zhang
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
authors.forename: Chunyang
authors.initials: C
authors.lastname: Du
authors.forename: Song
authors.initials: S
authors.lastname: Zhao
authors.forename: Zhao
authors.initials: Z
authors.lastname: Qi
authors.forename: Qingxian
authors.initials: Q
authors.lastname: Zhang
authors.forename: Huijun
authors.initials: H
authors.lastname: Duan
mesh_terms: D002478:Cells, Cultured; D005353:Fibronectins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D053614:Janus Kinase 2 / Q000378:metabolism; D050527:Mesangial Cells / Q000187:drug effects / Q000378:metabolism*; D010766:Phosphorylation; D016760:Proto-Oncogene Proteins c-fos / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D016755:Proto-Oncogene Proteins c-jun / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D050794:STAT1 Transcription Factor / Q000378:metabolism; D050796:STAT3 Transcription Factor / Q000378:metabolism; D000071222:Suppressor of Cytokine Signaling 1 Protein; D050826:Suppressor of Cytokine Signaling Proteins / Q000235:genetics / Q000378:metabolism*; D053773:Transforming Growth Factor beta1 / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D014443:Tyrosine / Q000378:metabolism
chemical_list: D005353:Fibronectins; D016760:Proto-Oncogene Proteins c-fos; D016755:Proto-Oncogene Proteins c-jun; C108944:SOCS1 protein, human; D050794:STAT1 Transcription Factor; C494079:STAT1 protein, human; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D000071222:Suppressor of Cytokine Signaling 1 Protein; D050826:Suppressor of Cytokine Signaling Proteins; D053773:Transforming Growth Factor beta1; D014443:Tyrosine; C507924:JAK2 protein, human; D053614:Janus Kinase 2; D005947:Glucose