title: Preparation and use of therapeutic antibodies primarily of human origin.
abstract: Therapeutic antibodies include polyclonal immunoglobulins isolated from regular or high-titered human plasma, sera from immunized animals, and monoclonal antibodies. This array of therapeutic antibodies is used for the prevention and treatment of many infectious diseases, antibody immunodeficiencies, autoimmune and inflammatory diseases, neurological disorders, and cancers. Polyclonal human immunoglobulins are available for intramuscular injection (IGIM), intravenous infusion (IGIV) and subcutaneous infusion (SCIG). We review these products and detail the therapeutic use of polyclonal human antibodies in the treatment of antibody immunodeficiencies, including their occasional local side effects (tenderness, sterile abscesses), minor systemic side effects (chills, muscle aches, malaise, headaches) and major side effects (aseptic meningitis, nephropathy, thrombosis).
authors.affiliation: Department of Pediatrics, UCLA Medical Center, Los Angeles, CA 90095, USA. estiehm@mednet.ucla.edu
authors.forename: E Richard
authors.initials: ER
authors.lastname: Stiehm
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Keller
authors.forename: Girish N
authors.initials: GN
authors.lastname: Vyas
mesh_terms: D000818:Animals; D000906:Antibodies / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000917:Antibody Formation / Q000276:immunology*; D015195:Drug Design; D006801:Humans; D007106:Immune Sera / Q000276:immunology; D007154:Immune System Diseases / Q000628:therapy*; D007074:Immunoglobulin G / Q000627:therapeutic use; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007167:Immunotherapy / Q000295:instrumentation / Q000379:methods*; D008962:Models, Theoretical
chemical_list: D000906:Antibodies; D000911:Antibodies, Monoclonal; D007106:Immune Sera; D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous