title: Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis in a Chinese Han population.
abstract: BACKGROUND
  Rhinitis and asthma are very common diseases involving genetic and environmental factors. Most patients with asthma also have rhinitis, which suggests the concept of 'one airway, one disease.' A disintegrin and metalloproteinase 33 (ADAM33) is the first asthma-susceptible gene to be discovered by positional cloning. To evaluate the potential influence of ADAM33 gene polymorphisms on allergic rhinitis (AR) and allergic asthma (AS), a case-control study was conducted on the Han population of northeast China.
  
  
  METHODS
  Six polymorphic sites (V4, T+1, T2, T1, S1, and Q-1) were genotyped in 128 patients with AR, 181 patients with AS, and 151 healthy controls (CTR). Genotypes were determined by the polymerase chain restriction fragment length polymorphism (PCR-RFLP) method. Data were analyzed using the chi-square test with Haploview software.
  
  
  RESULTS
  The single nucleotide polymorphisms (SNPs), V4 G/C, T+1 A/G, and T1 G/A, of the ADAM33 gene may be the causal variants in AR, whereas ADAM33 V4 G/C, T2 A/G, T1 G/A, and Q-1A/G may participate in the susceptibility of AS.
  
  
  CONCLUSIONS
  These results suggest that polymorphisms of the ADAM33 gene may modify individual susceptibility to AR and AS in a Chinese Han population.
authors.affiliation: Department of Respiratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, PR China. sudongju@yahoo.com.cn
authors.forename: Dongju
authors.initials: D
authors.lastname: Su
authors.forename: Ximei
authors.initials: X
authors.lastname: Zhang
authors.forename: Hong
authors.initials: H
authors.lastname: Sui
authors.forename: Fuzhen
authors.initials: F
authors.lastname: Lü
authors.forename: Lianhong
authors.initials: L
authors.lastname: Jin
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
mesh_terms: D051722:ADAM Proteins / Q000235:genetics*; D000328:Adult; D000483:Alleles; D001249:Asthma / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D015331:Cohort Studies; D005006:Ethnicity; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012221:Rhinitis, Allergic, Perennial / Q000235:genetics*
chemical_list: D051722:ADAM Proteins; C450441:ADAM33 protein, human
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