Serum total antioxidant statuses of survivors and nonsurvivors after acute paraquat poisoning.
BACKGROUND
The plasma paraquat (PQ) concentration is an excellent prognostic indicator. However, at the bedside, it is difficult to predict survivors even with known PQ concentrations. We examined the association of total antioxidant status (TAS) in serum to clinical outcome in patients with acute PQ intoxication.


METHODS
After acute PQ intoxication, 296 patients were admitted to the Institute of Pesticide Poisoning, Soonchunhyang University Cheonan Hospital, from January through December 2007. Serum total antioxidant levels in emergency department were compared between a survivor group and a nonsurvivor group.


RESULTS
Age, the amount of PQ ingested, plasma PQ concentration, leukocyte count, blood urea nitrogen (BUN), serum creatinine, uric acid, aspartate aminotransferase, alanine aminotransferase (ALT), and amylase in the emergency department were individually associated with the clinical outcome (p < 0.001), but TAS was not. Multiple logistic regression found the odds ratio (95% confidence interval) to be 10.79 (3.45-33.74) for plasma PQ concentration, but 0.43 (0.02-8.52) for TAS in serum. TAS was not associated with survival.


CONCLUSIONS
TAS in serum was not a significant influence on the clinical outcome in patients with acute PQ intoxication.
Yang
Jong-Oh
JO
Department of Internal Medicine, College of Medicine, Soonchunhyang University, Cheonan, Republic of Korea.
Gil
Hyo-Wook
HW
Kang
Mun-Soo
MS
Lee
Eun-Young
EY
Hong
Sae-Yong
SY
D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D016001:Confidence Intervals; D005260:Female; D006540:Herbicides / Q000097:blood / Q000506:poisoning*; D006801:Humans; D008111:Liver Function Tests; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010269:Paraquat / Q000097:blood / Q000506:poisoning*; D012189:Retrospective Studies; D017741:Survivors; D007507:Therapeutic Irrigation; D016896:Treatment Outcome
D000975:Antioxidants; D006540:Herbicides; D010269:Paraquat