Evolution of virulence in malaria.
The pathogenesis of severe malarial disease is not yet fully understood. It is clear that host immunopathology plays a central role, and a recent paper in BMC Evolutionary Biology suggests that the ability of the parasite to stimulate interleukin-10 production is a major factor and speculates on its impact on the coevolution of host and parasite.
Penman
Bridget
B
Department of Zoology, University of Oxford, Oxford, OX1 3PS, UK.
Gupta
Sunetra
S
D000818:Animals; D019143:Evolution, Molecular; D006790:Host-Parasite Interactions; D006801:Humans; D008288:Malaria / Q000276:immunology / Q000469:parasitology* / Q000473:pathology; D010963:Plasmodium falciparum / Q000276:immunology / Q000472:pathogenicity*; D014774:Virulence
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