title: Cognitive therapy versus medication for depression: treatment outcomes and neural mechanisms.
abstract: Depression is one of the most prevalent and debilitating of the psychiatric disorders. Studies have shown that cognitive therapy is as efficacious as antidepressant medication at treating depression, and it seems to reduce the risk of relapse even after its discontinuation. Cognitive therapy and antidepressant medication probably engage some similar neural mechanisms, as well as mechanisms that are distinctive to each. A precise specification of these mechanisms might one day be used to guide treatment selection and improve outcomes.
authors.affiliation: University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. derubeis@psych.upenn.edu
authors.forename: Robert J
authors.initials: RJ
authors.lastname: DeRubeis
authors.forename: Greg J
authors.initials: GJ
authors.lastname: Siegle
authors.forename: Steven D
authors.initials: SD
authors.lastname: Hollon
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D003071:Cognition / Q000187:drug effects / Q000502:physiology; D015928:Cognitive Behavioral Therapy / Q000379:methods / Q000706:statistics & numerical data* / Q000639:trends*; D003866:Depressive Disorder / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D006801:Humans; D008032:Limbic System / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D017397:Prefrontal Cortex / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D055502:Secondary Prevention; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents
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