title: Frajunolides E-K, briarane diterpenes from Junceella fragilis.
abstract: Chemical investigation of the gorgonian octocoral Junceella fragilis, collected in Taiwan, resulted in the isolation of seven new briarane-type diterpenes, frajunolides E-K (1-7), in addition to 14 known briaranes, praelolide, junceellin, junceellolides A-E, and K, 11a,20a-epoxy-4-deacetoxyjunceelolide D, umbraculolide A, junceellonoid A, and juncins Y, Z, and ZI, as well as ergosterol peroxide. The structures of 1-7 were determined by analysis of HRESIMS and 2D NMR spectroscopic data. Cytotoxicity and in vitro anti-inflammatory activities of compounds 1-7 were also evaluated.
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, Republic of China.
authors.forename: Chia-Ching
authors.initials: CC
authors.lastname: Liaw
authors.forename: Ya-Ching
authors.initials: YC
authors.lastname: Shen
authors.forename: Yun-Sheng
authors.initials: YS
authors.lastname: Lin
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.forename: Yao-Haur
authors.initials: YH
authors.lastname: Kuo
authors.forename: Ashraf Taha
authors.initials: AT
authors.lastname: Khalil
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D019833:Genistein / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects / Q000201:enzymology; D019906:Nuclear Magnetic Resonance, Biomolecular; D010196:Pancreatic Elastase / Q000096:biosynthesis / Q000187:drug effects; D013624:Taiwan
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D004224:Diterpenes; D019833:Genistein; D010196:Pancreatic Elastase