Drug rash with eosinophilia and systemic symptoms and graft-versus-host disease developing sequentially in a patient.
We describe a case of drug rash with eosinophilia and systemic symptoms (DRESS) and graft-versus-host disease (GvHD) developing sequentially in a patient displaying reactivation of CMV. We discuss the possibility that similar pathogenic mechanisms may be involved in the development of DRESS and GvHD.
Natkunarajah
J
J
Department of Dermatology, King's College Hospital, London, UK. janakan@fsmail.net
Watson
K
K
Diaz-Cano
S
S
Mufti
G
G
du Vivier
A
A
Creamer
D
D
D000900:Anti-Bacterial Agents / Q000009:adverse effects; D003587:Cytomegalovirus / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000139:chemically induced*; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D004802:Eosinophilia / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D006086:Graft vs Host Disease / Q000139:chemically induced* / Q000473:pathology; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000473:pathology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D008222:Lymphokines / Q000276:immunology; D008228:Lymphoma, Non-Hodgkin / Q000628:therapy; D008297:Male; D008875:Middle Aged; D014775:Virus Activation
D000900:Anti-Bacterial Agents; D008222:Lymphokines; C022173:stem cell inhibitory factor