title: The Translational Research Working Group developmental pathway for anticancer agents (drugs or biologics).
abstract: The Translational Research Working Group (TRWG) was created as a national initiative to evaluate the current status of the National Cancer Institute's investment in translational research and envision its future. The TRWG conceptualized translational research as a set of six developmental processes or pathways focused on various clinical goals. One of those pathways describes the development of agents-both small molecules and biologics-for the treatment and prevention of cancer. The Agents Developmental Pathway was conceived not as a comprehensive description of the corresponding real-world processes, but rather as a tool designed to facilitate movement of an agent through the translational process to the point where it can begin definitive clinical testing. This article presents the Agents Developmental Pathway and discusses key challenges associated with the processes described.
authors.affiliation: University of Chicago, Chicago, Illinois, USA.
authors.forename: Richard L
authors.initials: RL
authors.lastname: Schilsky
authors.forename: Gary
authors.initials: G
authors.lastname: Gordon
authors.forename: Tona M
authors.initials: TM
authors.lastname: Gilmer
authors.forename: Sara A
authors.initials: SA
authors.lastname: Courtneidge
authors.forename: Lynn M
authors.initials: LM
authors.lastname: Matrisian
authors.forename: Oren
authors.initials: O
authors.lastname: Grad
authors.forename: William G
authors.initials: WG
authors.lastname: Nelson
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001688:Biological Products / Q000627:therapeutic use*; D015415:Biomarkers / Q000032:analysis; D019496:Cancer Vaccines / Q000627:therapeutic use*; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D009316:National Institutes of Health (U.S.); D009369:Neoplasms / Q000628:therapy*; D016730:Program Development; D012985:Software Design; D014481:United States
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D015415:Biomarkers; D019496:Cancer Vaccines
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