title: Label-free DNA sensor based on organic thin film transistors.
abstract: Organic thin film transistors (OTFTs) are excellent candidates for the application on disposable sensors due to their potentially low-cost fabrication process. A novel DNA sensor based on OTFTs with semiconducting polymer poly(3-hexylthiophene) has been fabricated by solution process. Both single- and double-strand DNA molecules are immobilized on the surface of the Au source/drain electrodes of different OTFT devices, producing a dramatic change in the performance of the devices, which is attributed to the increase of the contact resistances at the source/drain electrodes. Single-strand DNA and double-strand DNA are differentiated successfully in the experiments indicating that this is a promising technique for sensing DNA hybridization without labelling.
authors.affiliation: Department of Applied Physics, The Hong Kong Polytechnic University, Hong Kong, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Yan
authors.forename: Sheung Man
authors.initials: SM
authors.lastname: Mok
authors.forename: Jinjiang
authors.initials: J
authors.lastname: Yu
authors.forename: Helen L W
authors.initials: HL
authors.lastname: Chan
authors.forename: Mo
authors.initials: M
authors.lastname: Yang
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D004247:DNA / Q000737:chemistry* / Q000235:genetics; D004563:Electrochemistry / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008839:Microelectrodes; D020411:Oligonucleotide Array Sequence Analysis / Q000295:instrumentation* / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013194:Staining and Labeling; D014173:Transistors, Electronic
chemical_list: D004247:DNA