title: Pathological findings of multifocal choroiditis with panuveitis and punctate inner choroidopathy.
abstract: OBJECTIVE
  To compare the pathological findings between multifocal choroiditis with panuveitis (MCP) and punctate inner choroidopathy (PIC).
  
  
  METHODS
  Fourteen eyes of 14 patients clinically diagnosed as having MCP or PIC who underwent surgical excision of choroidal neovascularization (CNV) were studied. Immunohistochemical findings of the excised CNV in MCP (eight eyes) and PIC (six eyes) cases were compared. Antibodies against vascular endothelial growth factor (VEGF), CD68, CD3, and CD20 were used as primary antibodies.
  
  
  RESULTS
  Expression of VEGF and CD68 in the CNV was observed in all MCF and PIC cases. In three of eight eyes with MCP, intraocular inflammatory findings were found clinically, while immunohistochemical study demonstrated infiltration of CD20-positive B lymphocytes in the CNV. No B lymphocyte infiltration was found in the six eyes with PIC. No differences in pathological findings were found between the five MCP eyes without intraocular inflammation and the six PIC eyes, with all eyes showing no B lymphocyte infiltration.
  
  
  CONCLUSIONS
  In MPC cases showing clinical inflammatory findings, infiltration of B lymphocytes was also observed histopathologically, suggesting that the presence of inflammatory cells in the anterior chamber or vitreous body clinically is an indicator of active inflammatory CNV. However, this study clarifies that MCP eyes without intraocular inflammation and PIC eyes are not different in histopathological findings.
authors.affiliation: Department of Ophthalmology, School of Medicine, Nihon University, Tokyo, Japan. sshimada@olive.ocn.ne.jp.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Shimada
authors.affiliation: Department of Ophthalmology, School of Medicine, Nihon University, Tokyo, Japan.
authors.forename: Mitsuko
authors.initials: M
authors.lastname: Yuzawa
authors.affiliation: Department of Ophthalmology, School of Medicine, Nihon University, Tokyo, Japan.
authors.forename: Tokihito
authors.initials: T
authors.lastname: Hirose
authors.affiliation: Department of Ophthalmology, School of Medicine, Nihon University, Tokyo, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakashizuka
authors.affiliation: Department of Ophthalmology, School of Medicine, Nihon University, Tokyo, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Hattori
authors.affiliation: Department of Ophthalmology, School of Medicine, Nihon University, Tokyo, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kazato
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D020256:Choroidal Neovascularization / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D002833:Choroiditis / Q000473:pathology*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D015864:Panuveitis / Q000473:pathology*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D015703:Antigens, CD; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A
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