title: m7GTP alphaS is a strong and stable inhibitor of cap-dependent translation.
abstract: Two diastereomers of 7-methylguanosine 5'-O-(1-thiotriphosphate) have been synthesized and resolved by RP HPLC. Preliminary studies revealed that these new analogs of mRNA cap are characterized by high affinity for eIF4E, resistance towards DcpS pyrophosphatase and high potency to inhibit cap-dependent translation.
authors.affiliation: Division of Biophysics, Institute of Experimental Physics, University of Warsaw, 02-089 Warsaw, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Kowalska
authors.forename: Maciej
authors.initials: M
authors.lastname: Lukaszewicz
authors.forename: Joanna
authors.initials: J
authors.lastname: Zuberek
authors.forename: Marcin
authors.initials: M
authors.lastname: Ziemniak
authors.forename: Malwina
authors.initials: M
authors.lastname: Strenkowska
authors.forename: Edward
authors.initials: E
authors.lastname: Darzynkiewicz
authors.forename: Jacek
authors.initials: J
authors.lastname: Jemielity
mesh_terms: D000818:Animals; D039561:Eukaryotic Initiation Factor-4E / Q000378:metabolism; D006160:Guanosine Triphosphate / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D014176:Protein Biosynthesis / Q000187:drug effects*; D011500:Protein Synthesis Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D012314:RNA Cap Analogs / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011817:Rabbits; D013237:Stereoisomerism
chemical_list: C541620:7-methylguanosine 5'-O-(1-thiotriphosphate); D039561:Eukaryotic Initiation Factor-4E; D011500:Protein Synthesis Inhibitors; D012314:RNA Cap Analogs; D006160:Guanosine Triphosphate