[Selection of antipsychotic drugs in a psychiatric hospital based on the results of CATIE study].
OBJECTIVE
To choose typical or atypical antipsychotic drugs for treatment of schizophrenic patients in a psychiatric hospital.


METHODS
A standard method was used; this method considers four main evaluation criteria and four secondary criteria. The typical antipsychotic drug, perphenazine, was compared with the atypical antipsychotic drugs (olanzapine, quetiapine, risperidone and ziprasidone). The measures of efficacy of the most important criteria come from the clinical trial Clinical Antipsychotic Trials for Intervention Effectiveness (CATIE).


RESULTS
The scores of the different antipsychotic drugs were as follows: perphenazine, 59.68; olanzapine, 52.98; risperidone, 51.53; ziprasidone, 46.42 and quetiapine, 45.41. Olanzapine was equal to perphenazine when the cost criteria was reduced by 72.97%.


CONCLUSIONS
The typical antipsychotic drug perphenazine is the drug receiving the best assessment for the treatment of schizophrenia. Olanzapine is an alternative if its cost is reduced.
Gutiérrez-Suela
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Servicio de Farmacia, Sagrat Cor, Serveis de Salut Mental, Martorell, Barcelona, España. farmacia@hscjscormar.org
D000293:Adolescent; D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D006778:Hospitals, Psychiatric; D006801:Humans; D008875:Middle Aged; D012559:Schizophrenia / Q000188:drug therapy*; D055815:Young Adult
D014150:Antipsychotic Agents