title: Serum homocysteine in pre-eclampsia and eclampsia.
abstract: Pre-eclampsia and eclampsia are common obstetrical problem causing adverse effects on pregnancy outcome. Large bodies of evidences suggest that hyperhomocysteinemia is a causal factor of pre-eclampsia/eclampsia. This study designed to explore the association between hyperhomocysteinemia and pre-eclampsia/eclampsia, the knowledge of which expected to be used for prevention of pre-eclampsia and eclampsia. In a case-control study serum homocysteine was measured in 136 controls (healthy pregnant), 84 pre-eclamptic and 120 eclamptic pregnant women. Serum homocysteine in patients with pre-eclampsia (9.54 +/- 3.21 micromol/L) and eclampsia (10.57 +/- 3.39 micromol/L) found to be significantly increased compared to controls (6.86 +/- 2.47 micromol/L) (p < 0.001). Between pre-eclampsia and eclampsia, homocysteine found to be raised more in eclampsia compared to pre-eclampsia (p < 0.03). In conclusion, hyperhomocysteinemia is associated with pre-eclampsia as well as eclampsia, but in eclampsia the severity of homocysteine elevation is more compared to that in pre-eclampsia.
authors.affiliation: Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh. m_mhoque@yahoo.com
authors.forename: Md Mozammel
authors.initials: MM
authors.lastname: Hoque
authors.forename: Tania
authors.initials: T
authors.lastname: Bulbul
authors.forename: Monzarin
authors.initials: M
authors.lastname: Mahal
authors.forename: Nur-A-Farzana
authors.initials: NA
authors.lastname: Islam
authors.forename: Munira
authors.initials: M
authors.lastname: Ferdausi
mesh_terms: D000328:Adult; D001459:Bangladesh; D016022:Case-Control Studies; D004461:Eclampsia / Q000097:blood / Q000503:physiopathology*; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood / Q000503:physiopathology*; D010865:Pilot Projects; D011225:Pre-Eclampsia / Q000097:blood / Q000503:physiopathology*; D011247:Pregnancy; D012307:Risk Factors
chemical_list: D006710:Homocysteine