title: Effect of nano-calcium-enriched milk on calcium metabolism in ovariectomized rats.
abstract: This study was designed to examine the effect of different kinds of calcium enrichment on serum and urine indices of mineral status in ovariectomized rats. Twenty-four 7-week-old Sprague-Dawley female rats were divided into four groups, ovariectomized, and fed diets containing the following: (1) Control, non-Ca-enriched milk; (2) OVX1, calcium carbonate-enriched milk; (3) OVX2, ionized Ca-enriched milk; and (4) OVX3, nano-Ca-enriched milk. After 18 weeks of feeding, the food efficiency ratio in the nano-Ca-fed group was significantly lower compared with those in the Control and OVX2 groups. There was no difference in serum and fecal Ca among the groups. The bone/total alkaline phosphatase ratio was significantly higher in rats fed milk enriched with nano-Ca (59%) and calcium carbonate (62%) than in control (44%) animals. Urinary Ca was the highest in the nano-Ca-enriched group; however, urinary excretions of deoxypyridinoline and hydroxyproline were significantly decreased in the nano-Ca-enriched group. The present results indicate that consumption of nano-Ca-enriched milk resulted in an increase of urinary excretion of calcium and a decrease in deoxypyridinoline and hydroxyproline in ovariectomized rats.
authors.affiliation: Department of Food Science and Technology, Sejong University, Seoul, Republic of Korea.
authors.forename: Heung-Sik
authors.initials: HS
authors.lastname: Park
authors.forename: Joungjwa
authors.initials: J
authors.lastname: Ahn
authors.forename: Hae-Soo
authors.initials: HS
authors.lastname: Kwak
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000596:Amino Acids / Q000652:urine; D000818:Animals; D002118:Calcium / Q000097:blood / Q000378:metabolism* / Q000652:urine; D002119:Calcium Carbonate / Q000008:administration & dosage / Q000494:pharmacology; D002136:Calcium, Dietary / Q000008:administration & dosage / Q000494:pharmacology*; D016503:Drug Delivery Systems; D005260:Female; D005527:Food, Fortified; D006909:Hydroxyproline / Q000652:urine; D053758:Nanoparticles; D015675:Osteocalcin / Q000097:blood; D010052:Ovariectomy; D010758:Phosphorus / Q000097:blood / Q000652:urine; D051381:Rats; D017207:Rats, Sprague-Dawley; D015430:Weight Gain / Q000187:drug effects
chemical_list: D000596:Amino Acids; D002136:Calcium, Dietary; D015675:Osteocalcin; D010758:Phosphorus; C036020:deoxypyridinoline; D000469:Alkaline Phosphatase; D002119:Calcium Carbonate; D006909:Hydroxyproline; D002118:Calcium