[Analysis of chronic necrotizing pulmonary aspergillosis (CNPA) cases complicated with non-tuberculous mycobacteriosis (NTM)].
OBJECTIVE
To clarify the clinical feature of chronic necrotizing pulmonary aspergillosis (CNPA) complicated with non-tuberculous mycobacteriosis (NTM).


METHODS
Forty-one CNPA cases underlying NTM were analyzed according to their clinical backgrounds.


RESULTS
Concerning the radiological type of prior NTM, CNPA cases were classified into two groups; 1) resembling pulmonary tuberculosis that usually shows cavitary lesion and 2) micronodule and bronchiectasis pattern, and more than half of cases (61.0%) were classified as the latter type. Average duration between prior NTM and CNPA was 1354 days. Isolation of Aspergillus spp. from sputum was 15 out of 41 (36.6%). Positive rates for Aspergillus galactomannan antigen and anti-aspergillus antibody were 58.5%, 46.3% respectively. With regard to subspecies of mycobacteria, M. avium was most frequent (82.9%). Since 6.8% of NTM cases develop CNPA within 10 years, careful observation of CNPA was required for the management of NTM.
Fujiuchi
Satoru
S
Department of Respiratory Medicine, National Hospital Organization Dohoku National Hospital, 7 Hanasaki, Asahikawa-shi, Hokkaido 070-8644, Japan. fujiuchi@douhoku.hosp.go.jp
Sakunami
Michiko
M
Yamamoto
Yasushi
Y
Takeda
Akinori
A
Nishigaki
Yutaka
Y
Fujita
Yuka
Y
Yamazaki
Yasuhiro
Y
Fujikane
Toshiaki
T
D000368:Aged; D001228:Aspergillosis / Q000150:complications*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008172:Lung Diseases, Fungal / Q000150:complications*; D008297:Male; D009165:Mycobacterium Infections, Nontuberculous / Q000150:complications*; D009336:Necrosis; D014397:Tuberculosis, Pulmonary / Q000150:complications*