title: Lung adenocarcinoma with micropapillary component presenting with metastatic scrotum tumor and cancer-to-cancer metastasis: A case report.
abstract: A 54-year-old man was admitted to the hospital presenting with a 3-month history of sclerosing dermal lesion in the external genitalia. A scrotal skin biopsy revealed a poorly-differentiated adenocarcinoma, immunohistochemically positive for cytokeratin 7 (CK7) and for thyroid transcription factor 1 (TTF-1), and negative for CK20. One month after admission, he died of respiratory failure. At autopsy, a consolidating lesion with vague margin was noted in the left lung as well as a well-circumscribed nodule in the right lobe of the thyroid. Histopathologically, pulmonary lesion was adenocarcinoma with a micropapillary component. On the other hand, thyroid tumor was diagnosed as a follicular variant of papillary carcinoma with foci of micropapillary adenocarcinoma. Positive immunohistochemistry for surfactant protein on micoropapillary component was useful to confirm that micropapillary component was of lung adenocarcinoma origin.
authors.affiliation: Division of Pathology, Department of Pathology, Kobe University, Graduate School of Medicine, Japan. kitazawa@med.kobe-u.ac.jp.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Mori
authors.forename: Riko
authors.initials: R
authors.lastname: Kitazawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kondo
authors.forename: Sohei
authors.initials: S
authors.lastname: Kitazawa
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