Evaluation of characteristics and degree of remodeling in coronary atherosclerotic lesions by 64-detector multislice computed tomography (MSCT).
BACKGROUND
Multislice computed tomography (MSCT) permits reliable imaging of not only the coronary artery lumen but also vessel wall. It is assumed that both lipid-rich plaques and those that display positive remodeling are more prone to rupture and erosion with subsequent coronary events. The purpose of this study was to assess the correlation between the characteristics of coronary arteries by MSCT and several measures of coronary heart disease (CHD) risk.


METHODS
This study consisted of 424 consecutive participants who received MSCT and coronary angiography (CAG). We assessed coronary artery findings including coronary artery calcification (CAC), degree of remodeling and narrowing of lumen and characteristics including uric acid (UA) and high-sensitivity C-reactive protein (hs-CRP). Statistical analyses were conducted for four subgroups classified by the presence of significant stenosis and positive remodeling.


RESULTS
Hs-CRP was 2.10+/-2.70mg/L in positive remodeling (+) and stenosis (+) group (PS), 1.05+/-0.97mg/L in positive remodeling (-) and stenosis (+) group (nPS), 0.94+/-0.88mg/L in positive remodeling (+) and stenosis (-) group (PnS) and 0.44+/-0.49mg/L in positive remodeling (-) and stenosis (-) group (nPnS). The results of logistic regression analysis showed that hs-CRP was higher in PS compared with the other groups (p<0.001) and higher in nPS and PnS compared with nPnS (p<0.05).


CONCLUSIONS
Regardless of significant stenosis, positive remodeling by MSCT correlates to the increase of hs-CRP.
Tanaka
Muhei
M
Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Kajii cho, Hirokoji, Kawaramachi dori, Kamikyo ku, Japan.
Tomiyasu
Ki-ichiro
K
Fukui
Michiaki
M
Akabame
Satoshi
S
Kobayashi-Takenaka
Yoshiko
Y
Nakano
Koji
K
Kadono
Mayuko
M
Hasegawa
Goji
G
Oda
Yohei
Y
Nakamura
Naoto
N
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D002097:C-Reactive Protein / Q000378:metabolism; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology*; D003331:Coronary Vessels / Q000473:pathology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008055:Lipids / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D012306:Risk; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014527:Uric Acid / Q000378:metabolism
D008055:Lipids; D014527:Uric Acid; D002097:C-Reactive Protein