title: Sequence variant on 8q24 confers susceptibility to urinary bladder cancer.
abstract: We conducted a genome-wide SNP association study on 1,803 urinary bladder cancer (UBC) cases and 34,336 controls from Iceland and The Netherlands and follow up studies in seven additional case-control groups (2,165 cases and 3,800 controls). The strongest association was observed with allele T of rs9642880 on chromosome 8q24, 30 kb upstream of MYC (allele-specific odds ratio (OR) = 1.22; P = 9.34 x 10(-12)). Approximately 20% of individuals of European ancestry are homozygous for rs9642880[T], and their estimated risk of developing UBC is 1.49 times that of noncarriers. No association was observed between UBC and the four 8q24 variants previously associated with prostate, colorectal and breast cancers, nor did rs9642880 associate with any of these three cancers. A weaker signal, but nonetheless of genome-wide significance, was captured by rs710521[A] located near TP63 on chromosome 3q28 (allele-specific OR = 1.19; P = 1. 15 x 10(-7)).
authors.affiliation: Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.
authors.forename: Lambertus A
authors.initials: LA
authors.lastname: Kiemeney
authors.forename: Steinunn
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authors.lastname: Thorlacius
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authors.lastname: Sulem
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authors.initials: KK
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authors.forename: Julius
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authors.lastname: Gudmundsson
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authors.forename: Jon T
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authors.lastname: Bergthorsson
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authors.forename: Thorarinn
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authors.lastname: Blondal
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authors.lastname: Swinkels
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authors.lastname: Gudbjartsson
authors.forename: Sigurjon A
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authors.lastname: Gudjonsson
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authors.lastname: Thorleifsson
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authors.lastname: Mouy
authors.forename: Steinunn
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authors.lastname: Snorradottir
authors.forename: Donatella
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authors.lastname: Placidi
authors.forename: Marcello
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authors.lastname: Campagna
authors.forename: Cecilia
authors.initials: C
authors.lastname: Arici
authors.forename: Kvetoslava
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authors.lastname: Koppova
authors.forename: Eugene
authors.initials: E
authors.lastname: Gurzau
authors.forename: Peter
authors.initials: P
authors.lastname: Rudnai
authors.forename: Eliane
authors.initials: E
authors.lastname: Kellen
authors.forename: Silvia
authors.initials: S
authors.lastname: Polidoro
authors.forename: Simonetta
authors.initials: S
authors.lastname: Guarrera
authors.forename: Carlotta
authors.initials: C
authors.lastname: Sacerdote
authors.forename: Manuel
authors.initials: M
authors.lastname: Sanchez
authors.forename: Berta
authors.initials: B
authors.lastname: Saez
authors.forename: Gabriel
authors.initials: G
authors.lastname: Valdivia
authors.forename: Charlotta
authors.initials: C
authors.lastname: Ryk
authors.forename: Petra
authors.initials: P
authors.lastname: de Verdier
authors.forename: Annika
authors.initials: A
authors.lastname: Lindblom
authors.forename: Klaus
authors.initials: K
authors.lastname: Golka
authors.forename: D Timothy
authors.initials: DT
authors.lastname: Bishop
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Knowles
authors.forename: Sigfus
authors.initials: S
authors.lastname: Nikulasson
authors.forename: Vigdis
authors.initials: V
authors.lastname: Petursdottir
authors.forename: Eirikur
authors.initials: E
authors.lastname: Jonsson
authors.forename: Gudmundur
authors.initials: G
authors.lastname: Geirsson
authors.forename: Baldvin
authors.initials: B
authors.lastname: Kristjansson
authors.forename: Jose I
authors.initials: JI
authors.lastname: Mayordomo
authors.forename: Gunnar
authors.initials: G
authors.lastname: Steineck
authors.forename: Stefano
authors.initials: S
authors.lastname: Porru
authors.forename: Frank
authors.initials: F
authors.lastname: Buntinx
authors.forename: Maurice P
authors.initials: MP
authors.lastname: Zeegers
authors.forename: Tony
authors.initials: T
authors.lastname: Fletcher
authors.forename: Rajiv
authors.initials: R
authors.lastname: Kumar
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Matullo
authors.forename: Paolo
authors.initials: P
authors.lastname: Vineis
authors.forename: Anne E
authors.initials: AE
authors.lastname: Kiltie
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Gulcher
authors.forename: Unnur
authors.initials: U
authors.lastname: Thorsteinsdottir
authors.forename: Augustine
authors.initials: A
authors.lastname: Kong
authors.forename: Thorunn
authors.initials: T
authors.lastname: Rafnar
authors.forename: Kari
authors.initials: K
authors.lastname: Stefansson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001483:Base Sequence; D016022:Case-Control Studies; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D001749:Urinary Bladder Neoplasms / Q000235:genetics*
chemical_list: D005819:Genetic Markers
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