Virulence evolution in response to vaccination: the case of malaria.
One theory of why some pathogens are virulent (i.e., they damage their host) is that they need to extract resources from their host in order to compete for transmission to new hosts, and this resource extraction can damage the host. Here we describe our studies in malaria that test and support this idea. We go on to show that host immunity can exacerbate selection for virulence and therefore that vaccines that reduce pathogen replication may select for more virulent pathogens, eroding the benefits of vaccination and putting the unvaccinated at greater risk. We suggest that in disease contexts where wild-type parasites can be transmitted through vaccinated hosts, evolutionary outcomes need to be considered.
Mackinnon
M J
MJ
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK. mmackinnon@kilifi.kemri-wellcome.org
Gandon
S
S
Read
A F
AF
D000293:Adolescent; D000328:Adult; D000818:Animals; D005075:Biological Evolution; D002648:Child; D002675:Child, Preschool; D004195:Disease Models, Animal; D006790:Host-Parasite Interactions; D006801:Humans; D007223:Infant; D008288:Malaria / Q000453:epidemiology / Q000276:immunology / Q000469:parasitology / Q000517:prevention & control*; D017780:Malaria Vaccines / Q000008:administration & dosage*; D051379:Mice; D008875:Middle Aged; D016788:Plasmodium chabaudi / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology; D010963:Plasmodium falciparum / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology; D014611:Vaccination; D014774:Virulence / Q000235:genetics*
D017780:Malaria Vaccines
Evolution. 2006 Jul;60(7):1358-71
16929653
Science. 2003 May 30;300(5624):1362-4
12775814
Science. 2001 May 11;292(5519):1099-102
11352063
BMC Evol Biol. 2004 Sep 08;4:30
15355551
Evolution. 2003 Dec;57(12):2792-804
14761058
Q Rev Biol. 1996 Mar;71(1):37-78
8919665
Evolution. 2006 Jan;60(1):13-23
16568627
Evolution. 2002 Feb;56(2):213-23
11926490
J R Soc Interface. 2007 Oct 22;4(16):803-17
17264055
Int J Parasitol. 2005 Feb;35(2):145-53
15710435
Philos Trans R Soc Lond B Biol Sci. 2004 Jun 29;359(1446):965-86
15306410
Nat Genet. 2002 Dec;32(4):569-77
12457190
Exp Parasitol. 1995 Aug;81(1):90-6
7628572
Am J Trop Med Hyg. 2003 Mar;68(3):366-71
12685646
J Theor Biol. 1994 Aug 7;169(3):253-65
7967617
Trends Microbiol. 2003 May;11(5):206-7; author reply 208-9
12781521
Parasitology. 2003 Feb;126(Pt 2):103-12
12636347
Trop Med Int Health. 2006 Jan;11(1):115-24
16398762
Am J Trop Med Hyg. 2001 Jan-Feb;64(1-2 Suppl):57-67
11425178
Am Nat. 2006 Jul;168(1):41-53
16874614
Trends Microbiol. 2003 Mar;11(3):112-3; author reply 113-4
12648940
Infect Immun. 1993 Dec;61(12):5198-204
8225594
Proc Biol Sci. 2000 May 22;267(1447):985-90
10874747
Bull World Health Organ. 1999;77(8):624-40
10516785
Q Rev Biol. 1991 Mar;66(1):1-22
2052670
Am Nat. 2005 Jun;165(6):E155-67
15937740
Proc R Soc Lond B Biol Sci. 1983 Jun 22;218(1212):259-85
6136042
J Evol Biol. 2006 Sep;19(5):1620-30
16910991
Infect Genet Evol. 2002 Jul;1(4):287-96
12798007
J Theor Biol. 1996 Jun 7;180(3):181-7
8759527
Proc Biol Sci. 1997 Oct 22;264(1387):1435-43
9364784
Trends Microbiol. 2002 Jul;10(7):314-7
12110209
Nature. 2001 Dec 13;414(6865):751-6
11742400
Bull World Health Organ. 1976;54(6):685-93
800968
Evolution. 2004 Mar;58(3):455-69
15119430
Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6571-6
9177259
Proc Biol Sci. 1998 Feb 22;265(1393):317-25
9523434
Nature. 1985 Jun 6-12;315(6019):493-6
4000277
Proc Biol Sci. 2004 May 22;271(1543):1073-80
15293862
Lancet. 1990 Dec 15;336(8729):1457-60
1979090
Trends Microbiol. 1994 Mar;2(3):73-6
8156274
J Hyg (Lond). 1975 Oct;75(2):237-47
1058245
J Hyg (Lond). 1957 Jun;55(2):192-206
13439171
Trends Microbiol. 1994 Mar;2(3):76-81
8156275
Am J Trop Med Hyg. 1999 Jul;61(1 Suppl):4-19
10432041
J Infect Dis. 2000 Mar;181(3):1206-9
10720557
Virology. 2000 Feb 1;267(1):36-48
10648181
Trends Microbiol. 2003 May;11(5):205-6; author reply 208-9
12781520
Evolution. 2008 Sep;62(9):2359-71
18540947
Infect Immun. 1999 Feb;67(2):733-9
9916084
Parasitology. 1982 Oct;85 (Pt 2):411-26
6755367
Am J Trop Med Hyg. 2006 Apr;74(4):554-63
16606983
Evolution. 2006 May;60(5):957-69
16817536
Proc Natl Acad Sci U S A. 2005 May 24;102(21):7624-8
15894623
Proc Biol Sci. 1995 Sep 22;261(1362):389-93
8587880
J Infect Dis. 2002 Mar 15;185(6):820-7
11920300
Evolution. 1987 Sep;41(5):1127-1130
28563417
Trans R Soc Trop Med Hyg. 1999 May-Jun;93(3):283-6
10492760
Evolution. 1999 Jun;53(3):689-703
28565637
Am Nat. 2005 Nov;166(5):531-42
16224719
Am J Trop Med Hyg. 1992 May;46(5):503-10
1599043
Trends Microbiol. 2003 Jan;11(1):15-20
12526850
JAMA. 2005 Mar 23;293(12):1461-70
15784869
Nature. 1953 Aug 8;172(4371):228-30
13087170
J Theor Biol. 1983 Feb 7;100(3):411-26
6834864
PLoS Biol. 2004 Sep;2(9):E230
15221031
Evolution. 2003 Jul;57(7):1489-97
12940354
Proc Biol Sci. 1999 Apr 7;266(1420):741-8
10331293
Evolution. 2000 Feb;54(1):64-71
10937184
Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3715-9
8170975
Infect Immun. 1995 Jun;63(6):2323-6
7768616
Proc Biol Sci. 2007 Oct 22;274(1625):2629-38
17711832
Proc Biol Sci. 2001 Nov 22;268(1483):2331-7
11703873