title: Presynaptic type III neuregulin 1 is required for sustained enhancement of hippocampal transmission by nicotine and for axonal targeting of alpha7 nicotinic acetylcholine receptors.
abstract: Both the neuregulin 1 (Nrg1) and alpha7 nicotinic acetylcholine receptor (alpha7*nAChRs) genes have been linked to schizophrenia and associated sensory-motor gating deficits. The prominence of nicotine addiction in schizophrenic patients is reflected in the normalization of gating deficits by nicotine self-administration. To assess the role of presynaptic type III Nrg1 at hippocampal-accumbens synapses, an important relay in sensory-motor gating, we developed a specialized preparation of chimeric circuits in vitro. Synaptic relays from Nrg1(tm1Lwr) heterozygote ventral hippocampal slices to wild-type (WT) nucleus accumbens neurons (1) lack a sustained, alpha7*nAChRs-mediated phase of synaptic potentiation seen in comparable WT/WT circuits and (2) are deficient in targeting alpha7*nAChRs to presynaptic sites. Thus, selective alteration of the level of presynaptic type III Nrg1 dramatically affects the modulation of glutamatergic transmission at ventral hippocampal to nucleus accumbens synapses.
authors.affiliation: Department of Neurosciences, Columbia University, New York, New York 10032, USA.
authors.forename: Chongbo
authors.initials: C
authors.lastname: Zhong
authors.forename: Chuang
authors.initials: C
authors.lastname: Du
authors.forename: Melissa
authors.initials: M
authors.lastname: Hancock
authors.forename: Marjolijn
authors.initials: M
authors.lastname: Mertz
authors.forename: David A
authors.initials: DA
authors.lastname: Talmage
authors.forename: Lorna W
authors.initials: LW
authors.lastname: Role
mesh_terms: D000818:Animals; D002038:Bungarotoxins / Q000494:pharmacology; D003513:Cycloheximide / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D005786:Gene Expression Regulation / Q000187:drug effects / Q000235:genetics; D005968:Glutamate Decarboxylase / Q000378:metabolism; D018698:Glutamic Acid / Q000378:metabolism; D006624:Hippocampus / Q000502:physiology*; D047908:Intracellular Signaling Peptides and Proteins / Q000172:deficiency / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D020880:Neuregulins; D009538:Nicotine / Q000494:pharmacology*; D018722:Nicotinic Agonists / Q000494:pharmacology*; D009714:Nucleus Accumbens / Q000502:physiology; D009924:Organ Culture Techniques; D018408:Patch-Clamp Techniques / Q000379:methods; D017729:Presynaptic Terminals / Q000378:metabolism*; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D011978:Receptors, Nicotinic / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors; D050598:Vesicular Glutamate Transport Protein 1 / Q000378:metabolism; D064569:alpha7 Nicotinic Acetylcholine Receptor; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D002038:Bungarotoxins; C579166:Chrna7 protein, mouse; D018691:Excitatory Amino Acid Antagonists; D047908:Intracellular Signaling Peptides and Proteins; D020880:Neuregulins; D018722:Nicotinic Agonists; C108113:Nrg3 protein, mouse; D011500:Protein Synthesis Inhibitors; D011978:Receptors, Nicotinic; C493465:Slc17a7 protein, mouse; D050598:Vesicular Glutamate Transport Protein 1; D064569:alpha7 Nicotinic Acetylcholine Receptor; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D009538:Nicotine; D003513:Cycloheximide; D005968:Glutamate Decarboxylase; C401141:glutamate decarboxylase 2
references.citation: J Neurosci. 2005 Jun 29;25(26):6084-91
references.pmid: 15987938
references.citation: Restor Neurol Neurosci. 1998 Jun;12(2-3):195-201
references.pmid: 12671315
references.citation: Neuron. 2006 May 4;50(3):443-52
references.pmid: 16675398
references.citation: J Cell Biol. 2008 May 5;181(3):511-21
references.pmid: 18458158
references.citation: J Neurosci. 2005 Oct 12;25(41):9378-83
references.pmid: 16221846
references.citation: Neuron. 2000 Jan;25(1):79-91
references.pmid: 10707974
references.citation: Prog Neurobiol. 2003 Jul;70(4):319-45
references.pmid: 12963091
references.citation: Mol Psychiatry. 2005 Jan;10(1):40-68; image 5
references.pmid: 15263907
references.citation: J Neurosci. 2005 May 18;25(20):4974-84
references.pmid: 15901778
references.citation: Ann Med. 2004;36(1):62-71
references.pmid: 15000348
references.citation: Neuron. 2007 May 24;54(4):583-97
references.pmid: 17521571
references.citation: Neuron. 2000 May;26(2):443-55
references.pmid: 10839362
references.citation: Neuron. 2005 Jun 2;46(5):703-13
references.pmid: 15924857
references.citation: Trends Pharmacol Sci. 2004 Jun;25(6):317-24
references.pmid: 15165747
references.citation: J Physiol. 2005 Jan 1;562(Pt 1):245-56
references.pmid: 15498813
references.citation: Science. 1995 Sep 22;269(5231):1692-6
references.pmid: 7569895
references.citation: Neuropsychopharmacology. 2005 May;30(5):843-52
references.pmid: 15689964
references.citation: Neurosci Biobehav Rev. 2005;29(6):1021-34
references.pmid: 15964073
references.citation: J Neurosci. 2005 Nov 30;25(48):11133-44
references.pmid: 16319313
references.citation: Hippocampus. 2004;14(3):337-44
references.pmid: 15132433
references.citation: Hum Mol Genet. 2007 Dec 1;16(23):2921-32
references.pmid: 17884806
references.citation: Neuron. 1998 Feb;20(2):255-70
references.pmid: 9491987
references.citation: J Neurosci. 2002 Sep 15;22(18):7903-12
references.pmid: 12223543
references.citation: Psychopharmacology (Berl). 2006 Mar;184(3-4):292-305
references.pmid: 16001117
references.citation: Eur Psychiatry. 2000 Mar;15(2):115-22
references.pmid: 10881208
references.citation: J Neurosci. 2006 Nov 1;26(44):11295-303
references.pmid: 17079657
references.citation: Eur Psychiatry. 2005 Jan;20(1):50-4
references.pmid: 15642444
references.citation: Exp Cell Res. 2003 Mar 10;284(1):14-30
references.pmid: 12648463
references.citation: Neuron. 2007 Apr 5;54(1):73-87
references.pmid: 17408579
references.citation: J Neurosci. 2007 Apr 25;27(17):4519-29
references.pmid: 17460065
references.citation: J Cell Biol. 2003 Jun 23;161(6):1133-41
references.pmid: 12821646
references.citation: J Neurosci. 2001 Aug 1;21(15):5660-9
references.pmid: 11466437
references.citation: Mol Cell Neurosci. 2006 Dec;33(4):381-8
references.pmid: 17029981