Synthesis of novel carbazole based macrocyclic amides as potential antimicrobial agents.
A series of carbazole based macrocyclic diamides with thia and oxy linkages have been synthesized and the inhibitory activity of the cyclophane amides against human pathogenic bacteria and plant pathogenic fungi are documented. (S)-1,10-Bi-2-naphthol [(S)-BINOL] based chiral carbazolophane amide emerged as the most interesting compound in this series exhibiting excellent antibacterial and antifungal activities.
Rajakumar
Perumal
P
Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai, India. perumalrajakumar@hotmail.com
Sekar
Karuppannan
K
Shanmugaiah
Vellasamy
V
Mathivanan
Narayanasamy
N
D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002227:Carbazoles / Q000737:chemistry*; D015195:Drug Design; D005658:Fungi / Q000187:drug effects; D006801:Humans; D047028:Macrocyclic Compounds / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D010944:Plants / Q000382:microbiology
D000577:Amides; D000890:Anti-Infective Agents; D002227:Carbazoles; D047028:Macrocyclic Compounds; C041514:carbazole