title: Study on the oxidative stress status among cement plant workers.
abstract: The cement industry is considered as a major pollution problem because of dust and particulate matter emitted at various steps of cement production. In the present study, volunteer male workers from a cement factory were studied for oxidative and nitrosative stress biomarkers in relation to their serum levels of aluminum (Al) and chromium (Cr). The subjects were divided into two groups of direct and indirect exposure. Subject who worked in production steps were considered as direct exposure group, and those who worked in administration building were considered as indirect exposure group. For comparison, healthy subjects at the same age and socioeconomic status were tested as a control group. Serum levels of lipid peroxidation (LP), total antioxidant capacity (TAC), total thiol molecules (TTM), and nitric oxide (NO) as well as Al and Cr were measured. The results indicated a significant increase in Al (P = 0.001) and Cr (P = 0.009) levels in direct-exposed workers in comparison to healthy control group. Further, a significant increase in Al (P = 0.002) and Cr (P = 0.009) levels was observed in direct-exposed workers as compared to indirect-exposed one. Serum levels of TTM and TAC were significantly lower in both direct- and indirect-exposed groups in comparison to healthy control group (P = 0.00). Serum TTM and TAC were significantly lower in direct-exposed workers as compared to indirect-exposed ones (P = 0.00 and P = 0.024, respectively). There was no significant difference on the level of LP and NO among groups. A correlation was found between serum level of Cr, TAC, and platelets between direct- and indirect-exposed groups (P < 0.05). Further correlation was found among serum level of Cr and those of TTM, platelets, and chronic disease (P < 0.05). Chronic disease had a significant influence adjusted to other predictor variables on the post-shift values of Al (P < 0.05). Although plasma levels of Al and Cr were found in normal ranges, analyses confirm their role in impairment of TMM and TAC.
authors.affiliation: Faculty of Pharmacy, and Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: S
authors.initials: S
authors.lastname: Pournourmohammadi
authors.forename: P
authors.initials: P
authors.lastname: Khazaeli
authors.forename: S
authors.initials: S
authors.lastname: Eslamizad
authors.forename: A
authors.initials: A
authors.lastname: Tajvar
authors.forename: A
authors.initials: A
authors.lastname: Mohammadirad
authors.forename: M
authors.initials: M
authors.lastname: Abdollahi
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D017607:Aluminum Compounds / Q000097:blood; D000975:Antioxidants / Q000032:analysis; D017608:Chromium Compounds / Q000097:blood; D003252:Construction Materials / Q000009:adverse effects*; D004391:Dust; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009569:Nitric Oxide / Q000097:blood; D009784:Occupational Diseases / Q000097:blood / Q000209:etiology*; D016273:Occupational Exposure / Q000009:adverse effects*; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D010976:Platelet Count; D013438:Sulfhydryl Compounds / Q000097:blood
chemical_list: D000395:Air Pollutants, Occupational; D017607:Aluminum Compounds; D000975:Antioxidants; D017608:Chromium Compounds; D004391:Dust; D013438:Sulfhydryl Compounds; D009569:Nitric Oxide; D008315:Malondialdehyde