title: Optimization of a series of multi-isoform PI3 kinase inhibitors.
abstract: Optimization of the cellular and pharmacological activity of a novel series of PI3 kinase inhibitors targeting multiple isoforms is described.
authors.affiliation: UCB, Granta Park, Great Abington, Cambridge CB21 6GS, UK. benjamin.perry@addexpharma.com
authors.forename: Benjamin
authors.initials: B
authors.lastname: Perry
authors.forename: Rebekah
authors.initials: R
authors.lastname: Beevers
authors.forename: Gavin
authors.initials: G
authors.lastname: Bennett
authors.forename: George
authors.initials: G
authors.lastname: Buckley
authors.forename: Tom
authors.initials: T
authors.lastname: Crabbe
authors.forename: Lewis
authors.initials: L
authors.lastname: Gowers
authors.forename: Lynwen
authors.initials: L
authors.lastname: James
authors.forename: Kerry
authors.initials: K
authors.lastname: Jenkins
authors.forename: Chris
authors.initials: C
authors.lastname: Lock
authors.forename: Verity
authors.initials: V
authors.lastname: Sabin
authors.forename: Sara
authors.initials: S
authors.lastname: Wright
mesh_terms: D000284:Administration, Oral; D000818:Animals; D048588:Benzoxazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D020650:Combinatorial Chemistry Techniques; D020128:Inhibitory Concentration 50; D007527:Isoenzymes / Q000037:antagonists & inhibitors; D008297:Male; D015394:Molecular Structure; D000081082:Phosphoinositide-3 Kinase Inhibitors; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
chemical_list: D048588:Benzoxazines; D007527:Isoenzymes; D000081082:Phosphoinositide-3 Kinase Inhibitors; D011720:Pyrazoles