Transient neonatal myelosuppression after fetal exposure to maternal chemotherapy. Case report and review of the literature.
Transient neonatal myelosuppression (TNM) is a rare but potentially life-threatening adverse effect of fetal exposure to maternal chemotherapy during pregnancy. We report a case of TNM in a preterm infant born to a mother diagnosed with acute lymphoblastic leukemia during pregnancy. The mother received chemotherapy during the second and third trimester. The neonate was successfully treated with supportive care. In addition, we also conducted a medical literature review and identified another 14 cases of TNM. Although the long-term outcome of these children is not known, short-term survival is relatively good. Prompt recognition and aggressive treatment of infants at risk for TNM is mandatory.
Udink ten Cate
Floris E A
FE
Subdivision of Neonatology, Department of Pediatrics, VU University Medical Center, Amsterdam, The Netherlands.
ten Hove
Christine H
CH
Nix
Wendy M L E
WM
de Vries
Johanna I P
JI
van de Loosdrecht
Arjan A
AA
van Elburg
Ruurd M
RM
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001853:Bone Marrow / Q000187:drug effects* / Q000196:embryology / Q000473:pathology; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006801:Humans; D008431:Maternal-Fetal Exchange; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology / Q000628:therapy*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy* / Q000473:pathology; D011256:Pregnancy Outcome; D033581:Stem Cell Transplantation; D016896:Treatment Outcome