title: A brief educational intervention may increase public acceptance of emergency research without consent.
abstract: OBJECTIVE
  We hypothesized that knowing the regulations regarding emergency research without consent would increase public support for this type of research.
  
  
  METHODS
  Randomized controlled trial. Consecutive patients presenting during eight 24-h periods received one of two interviews; the intervention interview included an educational paragraph.
  
  
  RESULTS
  There were 473 (74% of eligible) patients who participated: 51% (95% confidence interval [CI] 46-55) were willing to be enrolled in a study using exception to informed consent; 84% (95% CI 80-87) believed that current therapy for cardiac arrest offers ≥ 50% chance of full recovery, and these patients were less willing to enroll (odds ratio [OR] 0.5, 95% CI 0.3-0.9). The educational intervention increased willingness to enroll (OR 1.3, 95% CI 1.0-1.6, p = 0.03).
  
  
  CONCLUSIONS
  A brief educational intervention had only a modest effect on willingness to participate in emergency research without consent. It may be more important to educate patients on the shortcomings of current therapy than on the ethical and regulatory justifications for such research.
authors.affiliation: Department of Emergency Medicine, Brigham & Women's Hospital, Boston, Massachusetts, USA.
authors.forename: Joshua N
authors.initials: JN
authors.lastname: Goldstein
authors.forename: Kate E
authors.initials: KE
authors.lastname: Delaney
authors.forename: Andrea J
authors.initials: AJ
authors.lastname: Pelletier
authors.forename: Jonathan
authors.initials: J
authors.lastname: Fisher
authors.forename: Phillip G
authors.initials: PG
authors.lastname: Blanc
authors.forename: Mark
authors.initials: M
authors.lastname: Halsey
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Pallin
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Camargo
mesh_terms: D035843:Biomedical Research; D001900:Boston; D016009:Chi-Square Distribution; D016001:Confidence Intervals; D003710:Demography; D004636:Emergency Service, Hospital; D004638:Emergency Treatment; D005260:Female; D006801:Humans; D007258:Informed Consent; D007407:Interviews as Topic; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010353:Patient Education as Topic; D011639:Public Opinion; D011795:Surveys and Questionnaires