[Human embryonic stem cells. Perspectives for the study and therapy of neurological disorders].
The remarkable capability of human embryonic stem cells (hES cells) to differentiate into all somatic cell types and tissues opens promising perspectives for the development of novel therapeutic approaches for neurological disorders. This article provides an overview on the current state of research in this field. We present strategies and results on the generation of selected neural subtypes (dopaminergic neurons, retinal progenitors, motoneurons, oligodendrocytes) and discuss problems and risks associated with a potential clinical application of this novel cell source.
Nolden
L
L
Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, BRD.
Brüstle
O
O
D000826:Animal Testing Alternatives; D000818:Animals; D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology*; D002493:Central Nervous System Diseases / Q000235:genetics / Q000628:therapy*; D004252:DNA Mutational Analysis; D033041:Embryo Research; D053595:Embryonic Stem Cells / Q000637:transplantation*; D005786:Gene Expression Regulation / Q000235:genetics; D006650:Histocompatibility Testing; D006801:Humans; D009046:Motor Neurons / Q000166:cytology; D009416:Nerve Regeneration / Q000235:genetics / Q000502:physiology*; D009474:Neurons / Q000166:cytology*; D009836:Oligodendroglia / Q000166:cytology; D039904:Pluripotent Stem Cells / Q000637:transplantation*; D023822:Tissue Engineering