Immunological synapse: center of attention again.
The functional role of molecular clustering in the center of the immunological synapse is controversial. In this issue of Immunity, Cemerski et al. (2008) report that the synapse center can serve as a major site of sustained signal transduction.
Valitutti
Salvatore
S
INSERM, U563, Centre de Physiopathologie de Toulouse Purpan, Section Dynamique moléculaire des interactions lymphocytaires, Toulouse, F-31300 France.
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology* / Q000378:metabolism; D002450:Cell Communication; D006801:Humans; D007365:Intercellular Junctions / Q000276:immunology* / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
D011948:Receptors, Antigen, T-Cell