title: Top-down regulation of plasticity in the birdsong system: "premotor" activity in the nucleus HVC predicts song variability better than it predicts song features.
abstract: We studied real-time changes in brain activity during active vocal learning in the zebra finch songbird. The song nucleus HVC is required for the production of learned song. To quantify the relationship of HVC activity and behavior, HVC population activity during repeated vocal sequences (motifs) was recorded and temporally aligned relative to the motif, millisecond by millisecond. Somewhat surprisingly, HVC activity did not reliably predict any vocal feature except amplitude and, to a lesser extent, entropy and pitch goodness (sound periodicity). Variance in "premotor" HVC activity did not reliably predict variance in behavior. In contrast, HVC activity inversely predicted the variance of amplitude, entropy, frequency, pitch, and FM. We reasoned that, if HVC was involved in song learning, the relationship of HVC activity to learned features would be developmentally regulated. To test this hypothesis, we compared the HVC song feature relationships in adults and juveniles in the sensorimotor "babbling" period. We found that the relationship of HVC activity to variance in FM was developmentally regulated, with the greatest difference at an HVC vocalization lag of 50 ms. Collectively, these data show that, millisecond by millisecond, bursts in HVC activity predict song stability on-line during singing, whereas decrements in HVC activity predict plasticity. These relationships between neural activity and plasticity may play a role in vocal learning in songbirds by enabling the selective stabilization of parts of the song that match a learned tutor model.
authors.affiliation: Dept. of Neuroscience and Center for Neurobehavioral Development, Univ. of Minnesota Academic Health Center, Minneapolis, MN, USA.
authors.forename: Nancy F
authors.initials: NF
authors.lastname: Day
authors.forename: Amanda K
authors.initials: AK
authors.lastname: Kinnischtzke
authors.forename: Murtaza
authors.initials: M
authors.lastname: Adam
authors.forename: Teresa A
authors.initials: TA
authors.lastname: Nick
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D004569:Electroencephalography; D046369:Finches / Q000502:physiology*; D053400:High Vocal Center / Q000166:cytology* / Q000254:growth & development*; D008297:Male; D008954:Models, Biological; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D011237:Predictive Value of Tests; D011930:Reaction Time / Q000502:physiology; D013016:Sound; D014828:Vocalization, Animal / Q000502:physiology*
references.citation: J Neurosci. 2004 Jun 30;24(26):5849-62
references.pmid: 15229232
references.citation: Nat Rev Neurosci. 2001 Oct;2(10):704-16
references.pmid: 11584308
references.citation: Nature. 2005 Feb 10;433(7026):638-43
references.pmid: 15703748
references.citation: J Neurophysiol. 2007 Jan;97(1):806-16
references.pmid: 17079340
references.citation: Neuron. 2007 Jun 7;54(5):677-96
references.pmid: 17553419
references.citation: Am Sci. 1970 Nov-Dec;58(6):669-73
references.pmid: 5480089
references.citation: J Neurobiol. 2005 Mar;62(4):469-81
references.pmid: 15616963
references.citation: Proc Natl Acad Sci U S A. 1981 Dec;78(12):7815-9
references.pmid: 6950421
references.citation: Nature. 1995 Nov 2;378(6552):75-8
references.pmid: 7477292
references.citation: Nature. 2003 Feb 20;421(6925):844-8
references.pmid: 12594513
references.citation: J Neurosci. 2007 Nov 7;27(45):12308-20
references.pmid: 17989295
references.citation: J Neurophysiol. 2007 Jul;98(1):232-40
references.pmid: 17428907
references.citation: Ann N Y Acad Sci. 2004 Jun;1016:77-108
references.pmid: 15313771
references.citation: J Comp Neurol. 1976 Feb 15;165(4):457-86
references.pmid: 1262540
references.citation: J Neurophysiol. 2003 Dec;90(6):3931-49
references.pmid: 12944542
references.citation: J Neurobiol. 2005 Feb 5;62(2):231-42
references.pmid: 15459895
references.citation: J Neurophysiol. 2000 Sep;84(3):1204-23
references.pmid: 10979996
references.citation: J Neurobiol. 1999 Apr;39(1):14-28
references.pmid: 10213450
references.citation: Neuron. 1998 Oct;21(4):775-88
references.pmid: 9808464
references.citation: Nature. 2008 Jan 17;451(7176):305-10
references.pmid: 18202651
references.citation: Curr Opin Neurobiol. 1995 Aug;5(4):504-10
references.pmid: 7488853
references.citation: Science. 2001 Mar 30;291(5513):2564-9
references.pmid: 11283361
references.citation: Anim Behav. 2000 Jun;59(6):1167-1176
references.pmid: 10877896
references.citation: Nature. 2005 Feb 17;433(7027):710-6
references.pmid: 15716944
references.citation: Science. 2007 Mar 30;315(5820):1860-2
references.pmid: 17395832
references.citation: Nat Rev Neurosci. 2005 Nov;6(11):877-88
references.pmid: 16261181
references.citation: J Neurophysiol. 1963 Nov;26:1003-17
references.pmid: 14084161
references.citation: Z Tierpsychol. 1965 Dec;22(7):770-83
references.pmid: 5874921
references.citation: J Cogn Neurosci. 2004 Oct;16(8):1412-25
references.pmid: 15509387
references.citation: PLoS Biol. 2005 May;3(5):e153
references.pmid: 15826219
references.citation: Nat Neurosci. 1998 Oct;1(6):513-8
references.pmid: 10196550
references.citation: Science. 2008 May 2;320(5876):630-4
references.pmid: 18451295
references.citation: Science. 1984 May 25;224(4651):901-3
references.pmid: 6719123
references.citation: Proc Biol Sci. 2002 Dec 22;269(1509):2525-31
references.pmid: 12573066
references.citation: Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):14012-6
references.pmid: 11717459
references.citation: J Neurosci. 1994 Nov;14(11 Pt 2):6924-34
references.pmid: 7965088
references.citation: Proc Natl Acad Sci U S A. 1985 Sep;82(17):5997-6000
references.pmid: 16593601
references.citation: Nature. 2000 Apr 13;404(6779):762-6
references.pmid: 10783889
references.citation: J Neurosci. 1993 Nov;13(11):4737-47
references.pmid: 8229196
references.citation: J Neurosci. 2007 Aug 1;27(31):8387-94
references.pmid: 17670985
references.citation: Evolution. 1997 Apr;51(2):537-551
references.pmid: 28565357
references.citation: J Neurosci. 1990 May;10(5):1541-56
references.pmid: 2332796
references.citation: Nat Rev Neurosci. 2000 Nov;1(2):147-8
references.pmid: 11252778
references.citation: J Neurosci. 1983 May;3(5):1039-57
references.pmid: 6842281
references.citation: Science. 1996 Sep 27;273(5283):1871-5
references.pmid: 8791594
references.citation: Nature. 2002 Sep 5;419(6902):65-70
references.pmid: 12214232
references.citation: Nat Rev Neurosci. 2006 May;7(5):347-57
references.pmid: 16760915
references.citation: J Neurosci. 2005 Mar 16;25(11):2811-22
references.pmid: 15772341
references.citation: Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):4097-102
references.pmid: 9108111
references.citation: J Neurophysiol. 2006 Sep;96(3):1441-55
references.pmid: 16723412
references.citation: J Neurosci. 1994 Nov;14(11 Pt 1):6652-66
references.pmid: 7965067
references.citation: Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):1088-93
references.pmid: 16418265
references.citation: Neuron. 2005 Aug 4;47(3):423-35
references.pmid: 16055065
references.citation: Science. 2001 Jun 22;292(5525):2295-9
references.pmid: 11423653
references.citation: Annu Rev Neurosci. 1999;22:567-631
references.pmid: 10202549
references.citation: J Theor Biol. 1975 Sep;53(1):205-14
references.pmid: 1195756