Myasthenia gravis: presentation and outcome in 104 patients managed in a single institution.
OBJECTIVE
Few studies have attempted to delineate the clinical profile of myasthenia gravis (MG) among people of Arab ancestry. Therefore, we sought to clarify the clinical profile, the outcome of treatment and the role of thymectomy in non-thymomatous MG in Saudi Arabia.


METHODS
We retrospectively studied 104 patients followed over a mean period of 7.2 years (range, 1 to 22 years) at the King Khaled University Hospital, Riyadh, Saudi Arabia. Disease outcomes were compared among thymectomized and non-thymectomized patients according to the post-intervention status criteria of the Myasthenia Gravis Foundation of America (MGFA).


RESULTS
Age of onset was 22.5+/-9.3 years (meanA+/-SD) in females and 28.2+/-15.9 years in males, with peaks in the second and third decades among females and the third and fourth decades among males. At diagnosis, a majority of patients had moderate generalized weakness, equivalent to MGFA class III severity. After medical treatment with or without thymectomy, 9.6% of all patients had achieved complete stable remission, 3.8% had pharmacological remission, 27.9% had minimal manifestations, 23.1% were improved, 20.2% were unchanged and 15.4% were worse. Only thymectomized patients without a thymoma achieved remission, a significant benefit over those who had no thymectomy (P=.02).


CONCLUSIONS
MG presents at a younger age among Saudi Arabs compared to other racial groups. Thymectomy conferred significant benefits towards achievement of remission.
Al-Moallem
Mansour A
MA
Department of Medicine, King Khaled University Hospital, King Saud University, Riyadh, Saudi Arabia.
Alkali
Nura H
NH
Hakami
Mohammed A
MA
Zaidan
Radwan M
RM
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D018912:Arabs; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000208:ethnology / Q000628:therapy*; D012074:Remission Induction / Q000379:methods; D012189:Retrospective Studies; D012529:Saudi Arabia / Q000453:epidemiology / Q000208:ethnology; D012720:Severity of Illness Index; D013934:Thymectomy; D016896:Treatment Outcome; D055815:Young Adult
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