title: Can genes for mammographic density inform cancer aetiology?
abstract: Mammographic density (MD) reflects variations in fat, stromal and epithelial tissues that are thought to be regulated by several genes. High MD is an established risk factor for breast cancer; therefore, genes that regulate MD may indirectly influence breast cancer. These genes might also be fewer in number and easier to identify than those for breast cancer risk outside of inherited predisposition syndromes. In this Perspective, we review the limited genetic studies of MD and propose future directions.
authors.affiliation: Department of Population Health Research, Alberta Cancer Board, 1,331 29th Street North West, Calgary, Alberta T2N 4N2, Canada.
authors.forename: Linda E
authors.initials: LE
authors.lastname: Kelemen
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Sellers
authors.forename: Celine M
authors.initials: CM
authors.lastname: Vachon
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D002394:Catechol O-Methyltransferase / Q000235:genetics; D047628:Estrogen Receptor alpha / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics; D008327:Mammography; D011110:Polymorphism, Genetic
chemical_list: D014408:Biomarkers, Tumor; C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; D007334:Insulin-Like Growth Factor I; D002394:Catechol O-Methyltransferase
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