title: The generation and maintenance of genetic variation by frequency-dependent selection: constructing polymorphisms under the pairwise interaction model.
abstract: Frequency-dependent selection remains the most commonly invoked heuristic explanation for the maintenance of genetic variation. For polymorphism to exist, new alleles must be both generated and maintained in the population. Here we use a construction approach to model frequency-dependent selection with mutation under the pairwise interaction model. The pairwise interaction model is a general model of frequency-dependent selection at the genotypic level. We find that frequency-dependent selection is able to generate a large number of alleles at a single locus. The construction process generates multiallelic polymorphisms with a wide range of allele-frequency distributions and genotypic fitness relationships. Levels of polymorphism and mean fitness are uncoupled, so constructed polymorphisms remain permanently invasible to new mutants; thus the model never settles down to an equilibrium state. Analysis of constructed fitness sets reveals signatures of heterozygote advantage and positive frequency dependence.
authors.affiliation: Allan Wilson Centre for Molecular Ecology and Evolution, Department of Zoology, University of Otago, Dunedin, New Zealand, 9054.
authors.forename: Meredith V
authors.initials: MV
authors.lastname: Trotter
authors.forename: Hamish G
authors.initials: HG
authors.lastname: Spencer
mesh_terms: D005787:Gene Frequency; D005828:Genetics, Population; D006801:Humans; D008957:Models, Genetic; D011110:Polymorphism, Genetic / Q000235:genetics*; D012641:Selection, Genetic
references.citation: Genetics. 2007 Jul;176(3):1729-40
references.pmid: 17483410
references.citation: Evolution. 2008 Feb;62(2):255-65
references.pmid: 18302709
references.citation: Evolution. 2004 Dec;58(12):2783-7
references.pmid: 15696755
references.citation: Genetics. 2007 Jul;176(3):1625-33
references.pmid: 17483422
references.citation: Genetics. 1966 Aug;54(2):595-609
references.pmid: 5968643
references.citation: Nature. 1973 Nov 9;246(5428):96-8
references.pmid: 4585855
references.citation: Proc R Soc Lond B Biol Sci. 1979 Sep 21;205(1161):453-74
references.pmid: 42055
references.citation: Am Nat. 2007 Nov;170(5):663-80
references.pmid: 17926289
references.citation: Genetics. 1988 Oct;120(2):605-13
references.pmid: 3197961
references.citation: Genetics. 1981 Feb;97(2):475-93
references.pmid: 17249079
references.citation: Nature. 2006 Jun 1;441(7093):633-6
references.pmid: 16738659
references.citation: Anim Behav. 1999 Oct;58(4):907-916
references.pmid: 10512664
references.citation: Genetics. 1986 May;113(1):161-76
references.pmid: 3710142
references.citation: Trends Ecol Evol. 1991 Mar;6(3):100-1
references.pmid: 21232435
references.citation: Mol Biol Evol. 1996 Jan;13(1):261-77
references.pmid: 8583899
references.citation: Genetics. 1981 Feb;97(2):457-73
references.pmid: 17249078
references.citation: Am Nat. 2006 Aug;168(2):182-93
references.pmid: 16874628
references.citation: Evolution. 1971 Jun;25(2):281-285
references.pmid: 28563106
references.citation: Genetics. 1990 May;125(1):215-30
references.pmid: 2341034
references.citation: Mol Biol Evol. 1985 May;2(3):206-16
references.pmid: 3871004
references.citation: Genetics. 1992 Jan;130(1):211-21
references.pmid: 1732162
references.citation: Genetics. 1978 Jan;88(1):149-69
references.pmid: 17248790
references.citation: Trends Ecol Evol. 1990 Oct;5(10):337-40
references.pmid: 21232387
references.citation: Genetics. 1966 Aug;54(2):577-94
references.pmid: 5968642
references.citation: Genetics. 1983 Sep;105(1):135-55
references.pmid: 17246152
references.citation: Evolution. 1977 Mar;31(1):85-90
references.pmid: 28567726
references.citation: Genetics. 1969 Apr;61(4):875-91
references.pmid: 17248443