Two novel triterpenoids from Dysoxylum hainanense.
Two novel rearranged oleanane-type triterpenes, dysoxyhainanin A ( 1) possessing a unique 1,3- cyclo-2,3- seco A ring with a formamido-containing appendage and dysoxyhainanin B ( 2) featuring an unprecedented 1,2-dinor-3,10:9,10- bisseco skeleton, were isolated from Dysoxylum hainanense. Dysoxyhainanin A ( 1) exhibited significant antibacterial activity against Gram-positive bacteria.
He
Xiu-Feng
XF
State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, P. R. China. jmyue@mail.shcnc.ac.cn
Wang
Xiao-Ning
XN
Gan
Li-She
LS
Yin
Sheng
S
Dong
Lei
L
Yue
Jian-Min
JM
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D018360:Crystallography, X-Ray; D029582:Meliaceae / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D014315:Triterpenes; C532776:dysoxyhainanin A; C532777:dysoxyhainanin B