Unlocked nucleic acid (UNA) and UNA derivatives: thermal denaturation studies.
A study on the thermal stability of duplexes formed between unlocked nucleic acid (UNA) modified DNA and RNA oligonucleotides and complementary DNA and RNA is presented. The acyclic UNA monomers are shown to induce a decrease in duplex thermal stability.
Jensen
Troels Bundgaard
TB
Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark. tje@ifk.sdu.dk
Langkjaer
Niels
N
Wengel
Jesper
J
D004247:DNA / Q000737:chemistry; D009691:Nucleic Acid Denaturation; D009841:Oligonucleotides / Q000737:chemistry*; D012313:RNA / Q000737:chemistry; D013696:Temperature; D014498:Uracil / Q000031:analogs & derivatives* / Q000737:chemistry
D009841:Oligonucleotides; C477371:locked nucleic acid; D014498:Uracil; D012313:RNA; D004247:DNA