[Study on mass transfer behavior of hemoglobin-based nanocapsule surface].
Three dimensional structure of the surface is an important factor that influences the mass transfer behavior of hemoglobin-based nanocapsule surface. In this paper, the modified double emulsion method was used to fabricate the blood substitute of hemoglobin-based nanocapsules, and with the use of different molecular weight of PEG as probes, the effects of different technical conditions (such as primary emulsion, double emulsion, polymer, solvent, et al) in the processing on the three dimensional structure of the nanocapsule surface were investigated in details. Researches indicated that the water-soluable solvent, such as ethyl acetate and acetone could effectively modulate the pore size of the nanocapsule surface. With the increasing of the ratio of water-soluble solvent, the pore size of the nanocapsules firstly increased and then decreased. The increasing of the extra-water volume, the prolongation of the solvent evaporation time, and the improvement of the stirring speed resulted in a bigger pore size, but the increasing of the solvent volume and PEG polymer could reduce the pore size of nanocapsule surface.
Sheng
Yan
Y
Engineering Research Center of Biomedical Materials Under Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.
Yuan
Yuan
Y
Shan
Xiaoqian
X
Zhang
Xiaolan
X
Cao
Xuying
X
D000096:Acetone / Q000737:chemistry; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001802:Blood Substitutes / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D002417:Cattle; D004655:Emulsions; D006454:Hemoglobins / Q000737:chemistry*; D053769:Nanocapsules / Q000737:chemistry*; D016062:Porosity; D012997:Solvents; D013499:Surface Properties
D001672:Biocompatible Materials; D001802:Blood Substitutes; D004655:Emulsions; D006454:Hemoglobins; D053769:Nanocapsules; D012997:Solvents; D000096:Acetone