title: A case report of nephrotic syndrome due to collapsing focal segmental glomerulosclerosis treated with low-density lipoprotein apheresis.
abstract: We herein report the case of a 73-year-old woman with steroid and cyclosporine resistant collapsing focal segmental glomerulosclerosis (FSGS) whose refractory proteinuria and hypoproteinemia were controlled with low-density lipoprotein apheresis (LDL-A). She was initially treated with steroid therapy, including methylprednisolone pulse and cyclosporine therapy. However, her hypoproteinemia, accompanied with renal insufficiency, persisted despite these therapies. We treated her using LDL-A and found improvement in her urine protein excretion, hyperlipidemia, hypoproteinemia, and renal function as a result of this treatment. This suggests that LDL-A may therefore be an effective therapy for nephrotic syndrome due to collapsing FSGS.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan. Email: miyazono@cc.saga-u.ac.jp
authors.forename: Motoaki
authors.initials: M
authors.lastname: Miyazono
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Tomiyoshi
authors.forename: Tomoya
authors.initials: T
authors.lastname: Kishi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Takanobu
authors.initials: T
authors.lastname: Sakemi
authors.forename: Toru
authors.initials: T
authors.lastname: Sanai
authors.forename: Koichi
authors.initials: K
authors.lastname: Node
mesh_terms: D000368:Aged; D001781:Blood Component Removal / Q000379:methods*; D016572:Cyclosporine / Q000627:therapeutic use; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications / Q000628:therapy*; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008077:Lipoproteins, LDL / Q000097:blood; D008775:Methylprednisolone / Q000008:administration & dosage; D009404:Nephrotic Syndrome / Q000209:etiology / Q000628:therapy*
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D008077:Lipoproteins, LDL; D016572:Cyclosporine; D008775:Methylprednisolone