title: Design and synthesis of peptide-oligonucleotide conjugates as potential artificial ribonucleases.
abstract: A series of peptide-oligonucleotide conjugates was synthesized. The peptide fragment was attached to the middle part of DNA sequence. For this purpose the new amidophosphite dC with linker at C5-position was synthesized.
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, Siberian Division of Russian Academy of Sciences, Lavrent'ev ave. 8, Novosibirsk, Russia. inna_serpokrylova@biosset.com
authors.forename: Inna
authors.initials: I
authors.lastname: Serpokrylova
authors.forename: Ludmila
authors.initials: L
authors.lastname: Koroleva
authors.forename: Nadezhda
authors.initials: N
authors.lastname: Svischeva
authors.forename: Daria
authors.initials: D
authors.lastname: Novopashina
authors.forename: Vladimir
authors.initials: V
authors.lastname: Silnikov
mesh_terms: D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D017905:Phosphites / Q000138:chemical synthesis / Q000737:chemistry; D012260:Ribonucleases / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D009838:Oligodeoxyribonucleotides; D009943:Organophosphorus Compounds; D010455:Peptides; D017905:Phosphites; C434331:phosphoramidite; D012260:Ribonucleases