title: Diffusion tensor analysis of corpus callosum in progressive supranuclear palsy.
abstract: BACKGROUND
  Progressive supranuclear palsy (PSP) is a neurodegenerative disease featuring parkinsonism, supranuclear ophthalmoplegia, dysphagia, and frontal lobe dysfunction. The corpus callosum which consists of many commissure fibers probably reflects cerebral cortical function. Several previous reports showed atrophy or diffusion abnormalities of anterior corpus callosum in PSP patients, but partitioning method used in these studies was based on data obtained in nonhuman primates. In this study, we performed a diffusion tensor analysis using a new partitioning method for the human corpus callosum.
  
  
  METHODS
  Seven consecutive patients with PSP were compared with 29 age-matched patients with Parkinson's Disease (PD) and 19 age-matched healthy control subjects. All subjects underwent diffusion tensor magnetic resonance imaging, and the corpus callosum was partitioned into five areas on the mid-sagittal plane according to a recently established topography of human corpus callosum (CC1-prefrontal area, CC2-premotor and supplementary motor area, CC3-motor area, CC4-sensory area, CC5-parietal, temporal, and occipital area). Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were measured in each area and differences between groups were analyzed.
  
  
  RESULTS
  In the PSP group, FA values were significantly decreased in CC1 and CC2, and ADC values were significantly increased in CC1 and CC2. Receiver operating characteristic analysis showed excellent reliability of FA and ADC analyses of CC1 for differentiating PSP from PD.
  
  
  CONCLUSIONS
  The anterior corpus callosum corresponding to the prefrontal, premotor, and supplementary motor cortices is affected in PSP patients. This analysis can be an additional test for further confirmation of the diagnosis of PSP.
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan. sito@faculty.chiba-u.jp
authors.forename: Shoichi
authors.initials: S
authors.lastname: Ito
authors.forename: Takahiro
authors.initials: T
authors.lastname: Makino
authors.forename: Wakako
authors.initials: W
authors.lastname: Shirai
authors.forename: Takamichi
authors.initials: T
authors.lastname: Hattori
mesh_terms: D000368:Aged; D016880:Anisotropy; D003337:Corpus Callosum; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging; D005240:Feasibility Studies; D005260:Female; D005625:Frontal Lobe; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D013494:Supranuclear Palsy, Progressive / Q000175:diagnosis*
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