title: Acute ophthalmoparesis accompanied with Influenza A infection.
abstract: We report the first adult case of Influenza A virus infection with acute unilateral oculomotor nerve palsy. Unlike previous reports, our patient showed isolated unilateral oculomotor nerve palsy as soon as she developed general symptoms with Influenza A infection, and demonstrated no significant increases of anti-ganglioside antibodies including anti-GQ1b IgG antibody. She recovered immediately after treatment of oseltamivir phosphate. As for the mechanism by which Influenza A infection caused ophthalmoparesis, small vessel vasculitis due to direct invasion of the virus was speculated. Although influenza encephalitis/encephalopathy including acute necrotizing encephalopathy are most frequently reported in children, it is noteworthy that influenza virus can also cause focal neurological signs such as ophthalmoparesis in adult cases.
authors.affiliation: Department of Neurology, Kumamoto Medical Center, National Hospital Organization, Graduate School of Medical Sciences, Kumamoto University, Kumamoto. y-stsh@pg8.so-net.ne.jp
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamashita
authors.forename: Yanosuke
authors.initials: Y
authors.lastname: Kouzaki
authors.forename: Ryoko
authors.initials: R
authors.lastname: Kawano
authors.forename: Makoto
authors.initials: M
authors.lastname: Tokunaga
authors.forename: Makoto
authors.initials: M
authors.lastname: Uchino
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification; D007251:Influenza, Human / Q000150:complications* / Q000188:drug therapy; D009886:Ophthalmoplegia / Q000150:complications*; D053139:Oseltamivir / Q000627:therapeutic use
chemical_list: D053139:Oseltamivir