Association between daily ambulatory activity patterns and exercise performance in patients with intermittent claudication.
OBJECTIVE
To determine the association between daily ambulatory activity patterns and exercise performance in patients with intermittent claudication.


METHODS
One hundred thirty-three patients limited by intermittent claudication participated in this study. Patients were assessed on their ambulatory activity patterns for 1 week with a small, lightweight step activity monitor attached to the ankle using elastic velcro straps above the lateral malleolus of the right leg. The step activity monitor recorded the number of strides taken on a minute-to-minute basis and the time spent ambulating. Patients also were characterized on ankle-brachial index (ABI), ischemic window (IW) after a treadmill test, as well as initial claudication distance (ICD), and absolute claudication distance (ACD) during treadmill exercise.


RESULTS
The patient characteristics (mean +/- SD) were as follows: ABI = 0.71 +/- 0.23, IW = 0.54 +/- 0.72 mm Hg.min.meter(-1), ICD = 236 +/- 198 meters, and ACD = 424 +/- 285 meters. The patients took 3366 +/- 1694 strides/day, and were active for 272 +/- 103 min/day. The cadence for the 30 highest, consecutive minutes of each day (15.1 +/- 7.2 strides/min) was correlated with ICD (r = 0.316, P < .001) and ACD (r = 0.471, P < 0.001), and the cadence for the 60 highest, consecutive minutes of each day (11.1 +/- 5.4 strides/min) was correlated with ICD (r = 0.290, P < .01) and ACD (r = 0.453, P < .001). Similarly, the cadences for the highest 1, 5, and 20 consecutive minutes, and the cadence for the 30 highest, nonconsecutive minutes all were correlated with ICD and ACD (P < .05). None of the ambulatory cadences were correlated with ABI (P > .05) or with ischemic window (P > .05).


CONCLUSIONS
Daily ambulatory cadences are associated with severity of intermittent claudication, as measured by ACD and ICD, but not with peripheral hemodynamic measures.
Gardner
Andrew W
AW
CMRI Metabolic Research Program, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73117, USA. andrew-gardner@ouhsc.edu
Montgomery
Polly S
PS
Scott
Kristy J
KJ
Blevins
Steve M
SM
Afaq
Azhar
A
Nael
Raha
R
D000203:Activities of Daily Living; D000368:Aged; D000842:Ankle / Q000098:blood supply; D001794:Blood Pressure; D001916:Brachial Artery / Q000503:physiopathology; D003430:Cross-Sectional Studies; D005080:Exercise Test; D017079:Exercise Tolerance; D006801:Humans; D007383:Intermittent Claudication / Q000209:etiology / Q000503:physiopathology*; D007511:Ischemia / Q000150:complications* / Q000503:physiopathology; D035002:Lower Extremity / Q000098:blood supply*; D008875:Middle Aged; D018670:Monitoring, Ambulatory / Q000379:methods; D012720:Severity of Illness Index; D013997:Time Factors; D016138:Walking
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