title: Natural products as inspiration for the development of asymmetric catalysis.
abstract: Biologically active natural products often contain particularly challenging structural features and functionalities in terms of synthesis. Perhaps the greatest difficulties are those caused by issues of stereochemistry. A useful strategy for synthesizing such molecules is to devise methods of bond formation that provide opportunities for using enantioselective catalysis. In using this tactic, the desire for a particular target structure ultimately drives the development of catalytic methods. New enantioselective catalytic methods contribute to a greater fundamental understanding of how bonds can be constructed and lead to valuable synthetic technologies that are useful for a variety of applications.
authors.affiliation: The Arnold and Mabel Beckman Laboratories of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, MC 164-30, Pasadena, California 91125, USA.
authors.forename: Justin T
authors.initials: JT
authors.lastname: Mohr
authors.forename: Michael R
authors.initials: MR
authors.lastname: Krout
authors.forename: Brian M
authors.initials: BM
authors.lastname: Stoltz
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry*; D002227:Carbazoles / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D004224:Diterpenes / Q000138:chemical synthesis / Q000737:chemistry; D007189:Indans / Q000138:chemical synthesis / Q000737:chemistry; D026121:Indole Alkaloids / Q000138:chemical synthesis / Q000737:chemistry; D007212:Indolizines / Q000138:chemical synthesis / Q000737:chemistry; D007769:Lactams / Q000138:chemical synthesis / Q000737:chemistry; D011719:Pyrazines / Q000138:chemical synthesis / Q000737:chemistry; D000068900:Sitagliptin Phosphate; D013141:Spiro Compounds / Q000138:chemical synthesis / Q000737:chemistry; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D001688:Biological Products; D002227:Carbazoles; D004224:Diterpenes; D007189:Indans; D026121:Indole Alkaloids; D007212:Indolizines; D007769:Lactams; D011719:Pyrazines; D013141:Spiro Compounds; D014230:Triazoles; C530546:cyanthiwigin F; C526622:fluvirucinine A1; C504098:minfiensine; C041254:flustramine B; C013352:indacrinone; D000068900:Sitagliptin Phosphate; C518918:marcfortine B
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