Alpha(1) and alpha(2)-adrenoreceptor antagonists in streptozotocin- and vincristine-induced hyperalgesia.
The effect of alpha(1)- and alpha(2)-adrenoreceptor antagonists (prazosin and yohimbine, respectively) on streptozotocin (STZ)- and vincristine (VIN)-induced hyperalgesia in rats was studied. In two experimental models, yohimbine (1.0 mg/kg ip) completely abolished STZ and VIN-induced hyperalgesia. This effect was markedly prolonged in diabetic rats. Prazosin (0.3 mg/kg ip) attenuated and delayed development of STZ-induced hyperalgesia. In VIN-elicited neuropathy, the administration of prazosin not only delayed hyperalgesia but also produced antinociception. After cessation of drug administration, a significant decrease in nociceptive threshold was observed. The obtained results seem to indicate that both alpha(1)- and alpha(2)-adrenoreceptors are engaged in diabetic (STZ) and toxic (VIN) neuropathy.
Bujalska
Magdalena
M
Department of Pharmacodynamics, Medical University of Warsaw, Krakowskie Przedmieście 26/28, PL 00-927 Warszawa, Poland. mbujalska@gmail.com
Araźna
Monika
M
Makulska-Nowak
Helena
H
Gumułka
Stanisław W
SW
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D003929:Diabetic Neuropathies / Q000139:chemically induced* / Q000517:prevention & control; D006930:Hyperalgesia / Q000139:chemically induced* / Q000188:drug therapy*; D008297:Male; D010147:Pain Measurement; D011224:Prazosin / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D014750:Vincristine / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D015016:Yohimbine / Q000494:pharmacology* / Q000627:therapeutic use
D000317:Adrenergic alpha-Antagonists; D000903:Antibiotics, Antineoplastic; D015016:Yohimbine; D014750:Vincristine; D013311:Streptozocin; D011224:Prazosin