title: Influence of the formulation components on the properties of the system SLN-dextran hydrogel for the modified release of drugs.
abstract: A system composed by solid lipid nanoparticles (SLN) entrapped into a chemical hydrogel of dextran was recently proposed for the controlled release of lipophilic drugs in oral formulations. This study reports now an extension of such study focused on the investigation of how the nature and the amount of the formulation components are able to modify the properties of the system. In particular the concentration of the two surfactants used for the nanosuspension stabilization, the nature of the lipid phase used for the nanoparticles preparation, as well as the concentration and the derivatization degree of the polymer employed for the gel preparation were investigated. The effects of these variables on the physicochemical properties of the nanoparticles and/or on the release profiles of the model drug (S)-(+)-2-(4-isobutylphenyl)-propionic acid (ibuprofen) were reported and discussed. Rheological experiments on samples of SLN, dextran hydrogel, and SLN-dextran hydrogel were also performed.
authors.affiliation: Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, Rome, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Paolicelli
authors.forename: Felice
authors.initials: F
authors.lastname: Cerreto
authors.forename: Stefania
authors.initials: S
authors.lastname: Cesa
authors.forename: Michelle
authors.initials: M
authors.lastname: Feeney
authors.forename: Federica
authors.initials: F
authors.lastname: Corrente
authors.forename: Carlotta
authors.initials: C
authors.lastname: Marianecci
authors.forename: Maria Antonietta
authors.initials: MA
authors.lastname: Casadei
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D003911:Dextrans / Q000737:chemistry*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry; D007052:Ibuprofen / Q000008:administration & dosage*; D008055:Lipids / Q000737:chemistry*; D008689:Methacrylates / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D012212:Rheology; D013501:Surface-Active Agents / Q000737:chemistry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003911:Dextrans; D008055:Lipids; D008689:Methacrylates; D013501:Surface-Active Agents; C514458:methacrylated dextran; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D007052:Ibuprofen