Chemosensory and caloric mechanisms influence distinct components of mortality rate.
Both caloric and chemosensory mechanisms influence lifespan, but the relative importance of each of these mechanisms in mediating effects of dietary restriction on lifespan has been unclear. Here we demonstrate that chemosensory mechanisms consistently influence initial mortality rate, whereas caloric mechanisms consistently influence age-dependent acceleration of mortality rate. Based on this analysis, life-extending effects of dietary restriction are mediated primarily by caloric mechanisms in rats and nematodes and by both mechanisms in mice and flies.
Yen
Kelvin
K
Department of Neuroscience, Mount Sinai School of Medicine, One Gustave Levy Place, Box 1065, New York, NY 10029, USA.
Mobbs
Charles V
CV
D000367:Age Factors; D000818:Animals; D031204:Caloric Restriction / Q000379:methods / Q000401:mortality*; D019411:Clinical Laboratory Techniques; D004044:Dietary Proteins / Q000008:administration & dosage; D004175:Diptera; D002149:Energy Intake / Q000502:physiology*; D008136:Longevity / Q000502:physiology*; D051379:Mice; D009348:Nematoda; D051381:Rats; D015996:Survival Rate
D004044:Dietary Proteins