title: Crown ether ring-fused nucleosides: synthesis and conformational properties.
abstract: We here describe the synthesis of a series of novel bicyclic ribonucleoside derivatives, with 18-crown-6 ether moieties attached via their ribose 2- and 3- positions, as first examples of crown ether ring-fused nucleosides, to be evaluated as antiviral and/or antitumoral agents.
authors.affiliation: Dipartimento di Chimica Organica e Biochimica, Università degli Studi di Napoli Federico II, Complesso Universitario di Monte S. Angelo, via Cinthia, Napoli, Italy.
authors.forename: Cinzia
authors.initials: C
authors.lastname: Coppola
authors.forename: Jennifer
authors.initials: J
authors.lastname: D'Onofrio
authors.forename: Giovanni
authors.initials: G
authors.lastname: Di Fabio
authors.forename: Lorenzo
authors.initials: L
authors.lastname: De Napoli
authors.forename: Daniela
authors.initials: D
authors.lastname: Montesarchio
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry; D043844:Crown Ethers / Q000138:chemical synthesis* / Q000737:chemistry; D009690:Nucleic Acid Conformation; D012263:Ribonucleosides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D043844:Crown Ethers; D012263:Ribonucleosides