title: Finding genes underlying human disease.
abstract: With the surge in genome-wide association studies (GWAS), many have asked the question 'Are linkage studies dead?' In this article, we survey the approaches used in mapping human disease genes, reviewing the analysis strategies that preceded and laid the groundwork for GWAS. We note that earlier approaches are still useful and the development of new methodology is warranted.
authors.affiliation: Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA. cmstein@cwru.edu
authors.forename: C M
authors.initials: CM
authors.lastname: Stein
authors.forename: R C
authors.initials: RC
authors.lastname: Elston
mesh_terms: D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D014644:Genetic Variation; D015894:Genome, Human; D055106:Genome-Wide Association Study / Q000379:methods* / Q000706:statistics & numerical data / Q000639:trends; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide
references.citation: Stat Appl Genet Mol Biol. 2003;2:Article2
references.pmid: 16646780
references.citation: Am J Hum Genet. 1996 May;58(5):1072-84
references.pmid: 8651268
references.citation: Nature. 2004 Aug 12;430(7001):743-7
references.pmid: 15269782
references.citation: Am J Hum Genet. 1993 Mar;52(3):506-16
references.pmid: 8447318
references.citation: Ann Hum Genet. 2007 Jan;71(Pt 1):96-106
references.pmid: 17227480
references.citation: Am J Hum Genet. 2002 Dec;71(6):1330-41
references.pmid: 12454799
references.citation: Science. 1989 Sep 8;245(4922):1073-80
references.pmid: 2570460
references.citation: Ann Hum Genet. 2007 Nov;71(Pt 6):804-14
references.pmid: 17578507
references.citation: Genet Epidemiol. 2005 Jul;29(1):12-22
references.pmid: 15838848
references.citation: Am J Hum Genet. 1990 Feb;46(2):222-8
references.pmid: 2301392
references.citation: Am J Hum Genet. 1980 May;32(3):314-31
references.pmid: 6247908
references.citation: Genet Epidemiol. 2005 Nov;29(3):195-203
references.pmid: 16094613
references.citation: Am J Hum Genet. 1990 Feb;46(2):229-41
references.pmid: 2301393
references.citation: Am J Hum Genet. 1998 May;62(5):1198-211
references.pmid: 9545414
references.citation: Behav Genet. 1972 Mar;2(1):3-19
references.pmid: 4157472
references.citation: Am J Hum Genet. 1989 Mar;44(3):397-401
references.pmid: 2563634
references.citation: Eur J Hum Genet. 2000 Jul;8(7):545-51
references.pmid: 10909856
references.citation: Nat Rev Genet. 2002 Apr;3(4):299-309
references.pmid: 11967554
references.citation: Genet Epidemiol. 2005;29 Suppl 1:S72-6
references.pmid: 16342185
references.citation: Genet Epidemiol. 2007 Jan;31(1):18-30
references.pmid: 17096358
references.citation: BMC Genet. 2005 Dec 30;6 Suppl 1:S73
references.pmid: 16451687
references.citation: Am J Hum Genet. 1992 Jun;50(6):1235-42
references.pmid: 1598904
references.citation: Am J Hum Genet. 2001 Feb;68(2):466-77
references.pmid: 11170894
references.citation: Genet Epidemiol. 1987;4(3):193-201
references.pmid: 3609719
references.citation: Am J Hum Genet. 2001 May;68(5):1197-206
references.pmid: 11309685
references.citation: Am J Hum Genet. 2008 Feb;82(2):352-65
references.pmid: 18252216
references.citation: Am J Hum Genet. 1993 Feb;52(2):362-74
references.pmid: 8430697
references.citation: Nat Biotechnol. 2008 Mar;26(3):256
references.pmid: 18327223
references.citation: J Theor Biol. 1968 Aug;20(2):129-63
references.pmid: 5727236
references.citation: Am J Hum Genet. 1989 Mar;44(3):388-96
references.pmid: 2916582
references.citation: Science. 1996 Sep 13;273(5281):1516-7
references.pmid: 8801636
references.citation: Nature. 1995 Dec 21-28;378(6559):789-92
references.pmid: 8524414
references.citation: Hum Hered. 2005;60(4):206-10
references.pmid: 16391488
references.citation: Annu Rev Genomics Hum Genet. 2007;8:327-42
references.pmid: 17506660
references.citation: Genet Epidemiol. 2008 Nov;32(7):647-57
references.pmid: 18481794
references.citation: Nat Genet. 1995 Nov;11(3):241-7
references.pmid: 7581446
references.citation: Am J Hum Genet. 2005 Jan;76(1):152-6
references.pmid: 15540158
references.citation: Genet Epidemiol. 1997;14(6):987-92
references.pmid: 9433612
references.citation: Nature. 2007 Jun 7;447(7145):661-78
references.pmid: 17554300
references.citation: Am J Hum Genet. 2002 Apr;70(4):845-57
references.pmid: 11875755
references.citation: Biometrics. 1999 Dec;55(4):997-1004
references.pmid: 11315092
references.citation: Am J Hum Genet. 2005 Nov;77(5):754-67
references.pmid: 16252236
references.citation: Hum Hered. 2007;64(2):91-6
references.pmid: 17476108
references.citation: Nat Genet. 2007 Jul;39(7 Suppl):S37-42
references.pmid: 17597780
references.citation: Genet Epidemiol. 1997;14(6):719-35
references.pmid: 9433569
references.citation: Genet Epidemiol. 2000 Mar;18(3):217-35
references.pmid: 10723107
references.citation: Genetics. 2000 Jun;155(2):945-59
references.pmid: 10835412
references.citation: Am J Hum Genet. 1998 May;62(5):1228-42
references.pmid: 9599188
references.citation: Am J Hum Genet. 1999 Dec;65(6):1760-9
references.pmid: 10577930
references.citation: Nature. 2003 Dec 18;426(6968):789-96
references.pmid: 14685227
references.citation: Science. 1990 Dec 21;250(4988):1684-9
references.pmid: 2270482
references.citation: Genet Epidemiol. 1989;6(2):349-60
references.pmid: 2721929
references.citation: Am J Hum Genet. 1999 Jul;65(1):236-45
references.pmid: 10364537