title: [Clinical significance of prostatic intraepithelial neoplasm and atypical small acinar proliferation: relationship with prostate cancer].
abstract: BACKGROUND
  Prostatic intraepithelial neoplasia (PIN) and atypical small acinar proliferation (ASAP) in the setting of prostatic needle biopsies are considered premalignant although questions still remain.
  
  
  OBJECTIVE
  In this paper, we have studied the clinical relevance of these histologic findings.
  
  
  METHODS
  We collected 138 subjects (108 PIN, 30 ASAP); in 67% we performed a second biopsy and the rate of cancer in this late biopsy were 19% and 27% respectively. We cannot identify any clinical factor to predict the finding of cancer in the re-biopsy (PSA, age, digital rectal examination, prostatic volume).
  
  
  RESULTS
  In the follow-up, we observed higher rates of cancer for the ASAP; the finding of ASAP was the single clinical or histopathological factor that was an independent predictor of cancer.
  
  
  CONCLUSIONS
  We observed that the finding of ASAP was an indication for re-biopsy because of the higher rates of cancer; on the contrary, the paper of PIN in the prostatic needle biopsy still requires further investigation.
authors.affiliation: Servicio de Urología, Hospital Infanta Cristina Parla, Madrid. carlospascualmateo@yahoo.es
authors.forename: C
authors.initials: C
authors.lastname: Pascual Mateo
authors.forename: M
authors.initials: M
authors.lastname: Luján Galán
authors.forename: N
authors.initials: N
authors.lastname: Rodríguez García
authors.forename: L
authors.initials: L
authors.lastname: Llanes González
authors.forename: A
authors.initials: A
authors.lastname: Berenguer Sánchez
mesh_terms: D001706:Biopsy; D049109:Cell Proliferation; D006801:Humans; D008297:Male; D008875:Middle Aged; D019048:Prostatic Intraepithelial Neoplasia / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology*; D012189:Retrospective Studies