title: Does neuregulin-1 play a role in Type A behavior? The cardiovascular risk in young Finns study.
abstract: BACKGROUND
  Neuregulin-1 proteins are related to physiological correlates of Type A in terms of cardiac reactivity. Furthermore, neuregulin-1 gene (NRG1) may play a role in cardiovascular disease such as atherosclerosis and coronary heart disease i.e. the suggested "outcomes" of Type A behavior. Therefore, NRG1 is hypothesized to be associated with Type A behavior.
  
  
  METHODS
  The study examined whether Type A behavior pattern is associated with the single nucleotide polymorphism (SNP) SNP8NRG221533 of the NRG1. The subjects were 631 men and women participating in the population-based Cardiovascular Risk in Young Finns study in 1992 and 2001. Type A was self-assessed with the Framingham Type A Scale and reassessed nine years later.
  
  
  RESULTS
  Type A was associated with NRG1 genotype. Carriers of genotype CC scored lower on Type A compared to the others.
  
  
  CONCLUSIONS
  Our study has pinpointed a SNP in NRG1 that predicts Type A behavior. As previous evidence suggests an association for NRG1 with beta-adrenergic stimulation, its role underlying Type A is discussed.
authors.affiliation: Department of Psychology, University of Helsinki, Finland. liisa.keltikangas-jarvinen@helsinki.fi.
authors.forename: Helena M
authors.initials: HM
authors.lastname: Service
authors.forename: Mirka
authors.initials: M
authors.lastname: Hintsanen
authors.forename: Taina
authors.initials: T
authors.lastname: Hintsa
authors.forename: Terho
authors.initials: T
authors.lastname: Lehtimäki
authors.forename: Olli T
authors.initials: OT
authors.lastname: Raitakari
authors.forename: Jorma S
authors.initials: JS
authors.lastname: Viikari
authors.forename: Liisa
authors.initials: L
authors.lastname: Keltikangas-Järvinen
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