title: Pregnancy outcome in women before and after cervical conisation: population based cohort study.
abstract: OBJECTIVE
  To examine the consequences of cervical conisation in terms of adverse outcome in subsequent pregnancies.
  
  
  METHODS
  Population based cohort study.
  
  
  METHODS
  Data on cervical conisation derived from the Cancer Registry of Norway and on pregnancy outcome from the Medical Birth Registry of Norway, 1967-2003. 15 108 births occurred in women who had previously undergone cervical conisation and 57 136 who subsequently underwent cervical conisation. In the same period there were 2 164 006 births to women who had not undergone relevant treatment (control).
  
  
  RESULTS
  The proportion of preterm delivery was 17.2% in women who gave birth after cervical conisation versus 6.7% in women who gave birth before cervical conisation and 6.2% in women who had not undergone cervical conisation. The relative risk of a late abortion (<24 weeks' gestation) was 4.0 (95% confidence interval 3.3 to 4.8) in women who gave birth after cervical conisation compared with no cervical conisation. The relative risk of delivery was 4.4 (3.8 to 5.0) at 24-27 weeks, 3.4 (3.1 to 3.7) at 28-32 weeks, and 2.5 (2.4 to 2.6) at 33-36 weeks. The relative risk of preterm delivery declined during the study period and especially of delivery before 28 weeks' gestation.
  
  
  CONCLUSIONS
  Cervical conisation influences outcome in subsequent pregnancies in terms of an increased risk of preterm delivery, especially in the early gestational age groups in which the clinical significance is highest. A careful clinical approach should be taken in the selection of women for cervical conisation and in the clinical care of pregnancies after a cervical conisation.
authors.affiliation: Department of Obstetrics and Gynecology, Haukeland University Hospital, Institute of Clinical Medicine, University of Bergen, 5021 Bergen, Norway. Susanne.Albrechtsen@Helse-Bergen.no
authors.forename: Susanne
authors.initials: S
authors.lastname: Albrechtsen
authors.forename: Svein
authors.initials: S
authors.lastname: Rasmussen
authors.forename: Steinar
authors.initials: S
authors.lastname: Thoresen
authors.forename: Lorentz M
authors.initials: LM
authors.lastname: Irgens
authors.forename: Ole Erik
authors.initials: OE
authors.lastname: Iversen
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology*; D000328:Adult; D001724:Birth Weight; D015331:Cohort Studies; D019092:Conization / Q000009:adverse effects*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007752:Obstetric Labor, Premature / Q000209:etiology*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000601:surgery*; D011256:Pregnancy Outcome; D002583:Uterine Cervical Neoplasms / Q000601:surgery*; D002578:Uterine Cervical Dysplasia / Q000601:surgery*
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