Efficacy of carvedilol for ischemia/reperfusion-induced oxidative renal injury in rats.
In renal transplantation, ischemia/reperfusion (I/R) injury is related to production of reactive oxygen species. In addition to its antihypertensive action due to nonselective beta-adrenergic blocking activity, carvedilol has potent antioxidant activity. This study was designed to investigate the effects of carvedilol on I/R injury in rats. On postoperative days 2 and 4, serum creatinine levels were higher among the control and the metoprolol treatment groups compared with the carvedilol treatment group (P < .005). However, there were no significant differences on postoperative day 7. In conclusion, increased antioxidant modulation by carvedilol attenuated renal I/R injury.
Hayashi
T
T
Department of Urology, Kinki University School of Medicine, Osaka-Sayama, Japan. taihaya@ican.zaq.ne.jp
Saitou
Y
Y
Nose
K
K
Nishioka
T
T
Ishii
T
T
Uemura
H
H
D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002227:Carbazoles / Q000627:therapeutic use*; D000077261:Carvedilol; D003404:Creatinine / Q000097:blood; D007668:Kidney / Q000187:drug effects / Q000293:injuries*; D007677:Kidney Function Tests; D008297:Male; D008790:Metoprolol / Q000627:therapeutic use; D009392:Nephrectomy; D011412:Propanolamines / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012079:Renal Circulation / Q000187:drug effects / Q000502:physiology*; D015427:Reperfusion Injury / Q000150:complications* / Q000188:drug therapy*
D000959:Antihypertensive Agents; D002227:Carbazoles; D011412:Propanolamines; D000077261:Carvedilol; D003404:Creatinine; D008790:Metoprolol