Neoplasia and paracoccidioidomycosis.
Published studies on the association between cancer and paracoccidioidomycosis consist either isolated cases or clinical data based on hospital cohorts of paracoccidioidomycosis. The frequency of neoplasia in series of > or = 80 patients with paracoccidioidomycosis ranges from 0.16 to 14.1%, mean of 3.96%. There are only two retrospective controlled studies, one of them showing greater incidence of carcinoma in biopsy and necropsy samples of paracoccidioidomycosis (12 cases in 147 patients with the mycosis: 8.2%) than in the necropsies of the control group (320 cases in 7,302 necropsies: 4.9%). In the other, 22,409 autopsies were reviewed and 4,372 cases of cancer were found; of the 85 patients with paracoccidioidomycosis, 12 were diagnosed with cancer. No differences were observed in the frequency of malignancies between the group of patients with paracoccidioidomycosis (14.1%) and the control group (19.5%). Considering all the reported cases, carcinoma was more frequent than hematological malignancies, and was more often found at the same site or in a neighboring site affected by the mycosis, usually occurring after the diagnosis of the mycosis. Commonly, the basic cause of death was related to secondary infections or neoplasia. Lymphoma was associated with poorly organized rich in fungi granuloma. The clinical course and mortality were related to the cancer evolution or secondary infections and was worse in lymphoid series, metastatic carcinoma or in patients under cytotoxic chemotherapy. Additionally, as in several cases the clinical and histopathological data may mimick neoplasia, the correct diagnosis of both diseases is essential to guarantee an early and safe intervention.
Shikanai-Yasuda
M A
MA
Infectious and Parasitic Disease Dept., Laboratório de Investigação Médica em Imunologia do, Hospital das Clínica, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil. dmip.shikanai@hcnet.usp.br
Conceição
Y M T
YM
Kono
A
A
Rivitti
E
E
Campos
A F
AF
Campos
S V
SV
D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000150:complications / Q000453:epidemiology; D005260:Female; D006801:Humans; D007938:Leukemia / Q000150:complications / Q000453:epidemiology; D008223:Lymphoma / Q000150:complications / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications / Q000453:epidemiology; D010229:Paracoccidioidomycosis / Q000150:complications / Q000453:epidemiology
Prensa Med Argent. 1957 Feb 15;44(7):468-72
13453222
Mycopathologia. 1979 Sep 28;68(3):171-4
231206
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002 Nov;94(5):609-13
12424456
Rev Soc Bras Med Trop. 2000 May-Jun;33(3):309-12
10967600
Gen Dent. 2004 Jan-Feb;52(1):48-50
15055671
Allergol Immunopathol (Madr). 1980 May-Jun;8(3):185-8
7405765
Hospital (Rio J). 1948 Sep;34(3):313-26
18886753
J Neurosurg. 1978 Sep;49(3):425-8
682004
Br J Urol. 1992 Sep;70(3):329-30
1384922
Rev Inst Med Trop Sao Paulo. 1989 Mar-Apr;31(2):119-25
2690307
Mycopathologia. 1979 May 31;67(2):115-8
481558
J R Soc Med. 1991 Sep;84(9):562-3
1941863
Rev Inst Med Trop Sao Paulo. 1992 Mar-Apr;34(2):107-15
1340023
Diagn Cytopathol. 1992;8(2):198-9
1568417
Mycopathologia. 2005 Aug;160(1):25-8
16160765
Mycoses. 2003 Jun;46(5-6):229-32
12801369
Microbes Infect. 2002 Feb;4(2):139-44
11880044
Laryngoscope. 1984 May;94(5 Pt 1):608-11
6325837
Mycoses. 2006 Sep;49(5):393-6
16922791
J Med Vet Mycol. 1991;29(6):373-80
1815029
Med Mycol. 2006 Aug;44(5):399-404
16882606