Impact of depressive symptoms on visceral sensitivity among patients with different subtypes of irritable bowel syndrome.
The etiology of irritable bowel syndrome (IBS) is complex and multifaceted. Psychosocial factors play a role in such a process. Several reports suggest that IBS patients have increased psychopathology scores as compared with population controls. The influence of depressive symptoms on rectal sensitivity thresholds vary across different studies. The influence of predominant bowel habits on rectal sensitivity thresholds as determined by barostat-based investigations is not well established. The present report aimed to investigate the influence of depressive symptoms on rectal sensitivity in different subtypes of IBS patients (diarrhea/constipation-predominant vs. alternating subtypes). Depressive symptoms correlated well with first pain sensitivity threshold in alternating patients (n = 8; [rho] = -0.77; p = 0.02) but not in diarrhea/constipation predominant symptoms (n = 11; [rho] = -0.44; p = 0.27). These data suggest that depressive symptoms might impact pain thresholds differently according to the subtype of IBS.
de Medeiros
Maria Teresa Gonçalves
MT
Department of Clinical Medicine, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brasil. mtgmce@yahoo.com.br
Carvalho
André Férrer
AF
de Oliveira Lima
José Wellington
JW
Dos Santos
Armênio Aguiar
AA
de Oliveira
Ricardo Brandt
RB
Nobre E Souza
Miguel Angelo
MA
D000328:Adult; D003863:Depression / Q000503:physiopathology* / Q000523:psychology*; D005260:Female; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology*; D008297:Male; D009619:Nociceptors / Q000503:physiopathology; D017288:Pain Threshold / Q000502:physiology*; D010555:Personality Inventory; D012007:Rectum / Q000294:innervation*