title: Triazole oxytocin antagonists: identification of aryl ether replacements for a biaryl substituent.
abstract: Several potent aryl ether/triazole oxytocin antagonists are described. The lead compound in this series had significantly improved aqueous solubility over related systems containing a biaryl substituent.
authors.affiliation: Discovery Chemistry, Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK. Alan.D.Brown@pfizer.com
authors.forename: Alan
authors.initials: A
authors.lastname: Brown
authors.forename: Lindsay
authors.initials: L
authors.lastname: Brown
authors.forename: T Bruce
authors.initials: TB
authors.lastname: Brown
authors.forename: Andrew
authors.initials: A
authors.lastname: Calabrese
authors.forename: Dave
authors.initials: D
authors.lastname: Ellis
authors.forename: Nicholas
authors.initials: N
authors.lastname: Puhalo
authors.forename: Chris R
authors.initials: CR
authors.lastname: Smith
authors.forename: Olga
authors.initials: O
authors.lastname: Wallace
authors.forename: Lesa
authors.initials: L
authors.lastname: Watson
mesh_terms: D000284:Administration, Oral; D000818:Animals; D015394:Molecular Structure; D010121:Oxytocin / Q000037:antagonists & inhibitors*; D051381:Rats; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D014230:Triazoles; D010121:Oxytocin