title: Bilateral deep brain stimulation of the globus pallidus internus in tardive dystonia.
abstract: Tardive dystonia is a disabling movement disorder as a consequence of exposure to neuroleptic drugs. We followed 6 patients with medically refractory tardive dystonia treated by bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) for 21 +/- 18 months. At last follow-up, the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) motor score improved by 86% +/- 14%, and the BFMDRS disability score improved by 80% +/- 12%. Bilateral GPi-DBS is a beneficial therapeutic option for the long-term relief of tardive dystonia.
authors.affiliation: Department of Clinical Neuroscience, Institute of Health Biosciences, Graduate School of Medicine, University of Tokushima, Tokushima, Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Sako
authors.forename: Satoshi
authors.initials: S
authors.lastname: Goto
authors.forename: Hideki
authors.initials: H
authors.lastname: Shimazu
authors.forename: Nagako
authors.initials: N
authors.lastname: Murase
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Matsuzaki
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tamura
authors.forename: Hideo
authors.initials: H
authors.lastname: Mure
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Tomogane
authors.forename: Norio
authors.initials: N
authors.lastname: Arita
authors.forename: Hiroo
authors.initials: H
authors.lastname: Yoshikawa
authors.forename: Shinji
authors.initials: S
authors.lastname: Nagahiro
authors.forename: Ryuji
authors.initials: R
authors.lastname: Kaji
mesh_terms: D000328:Adult; D001703:Biophysics; D046690:Deep Brain Stimulation / Q000379:methods*; D004421:Dystonia / Q000628:therapy*; D005260:Female; D005917:Globus Pallidus / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome