Cross-talk between anti-beta1-adrenoceptor antibodies in dilated cardiomyopathy and Chagas' heart disease.
Anti-beta(1)-adrenoceptor autoantibodies, first described in sera of patients with Chagas' disease, are now well documented in patients with idiopathic dilated cardiomyopathy. The following review summarizes the knowledge we have about the structural basis of receptor-antibody interactions, about their mechanisms of action and about their pathogenicity. While the origin of anti-receptor antibodies with agonist-like activity in Chagas' disease might be ascribed to recognition by anti-parasite antibodies of an epitope, localized on the second extracellular loop of the beta(1)-adrenoceptor, the origin of such antibodies in idiopathic dilated cardiomyopathy remains unknown. The hypothesis of a similar origin for anti-receptor antibodies in both diseases is forwarded.
Levin
Mariano J
MJ
Laboratorio de Biología Molecular de la Enfermedad de Chagas, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigación, Ciencia y Tecnica, Buenos Aires, Argentina.
Hoebeke
Johan
J
D000595:Amino Acid Sequence; D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D002311:Cardiomyopathy, Dilated / Q000276:immunology*; D002598:Chagas Cardiomyopathy / Q000276:immunology* / Q000469:parasitology; D006801:Humans; D008969:Molecular Sequence Data; D018342:Receptors, Adrenergic, beta-1 / Q000276:immunology*; D014349:Trypanosoma cruzi / Q000276:immunology
D001323:Autoantibodies; D018342:Receptors, Adrenergic, beta-1