Biological accelerator mass spectrometry at Uppsala University.
A new research programme for the biological applications of accelerator mass spectrometry has been initiated at Uppsala University and the first results are presented. A (14)C-labelled pharmaceutical substance has been dissolved in human blood, plasma and urine and diluted over 3 orders of magnitude. The measured drug concentrations were found to be in good agreement with the predicted values. Furthermore, the effect of the sample preparation background contribution has been studied as the sample amount was varied down to sub-microl sizes.
Salehpour
Mehran
M
Ion Physics, Angström Laboratory, Department of Engineering Sciences, Box 534, Uppsala University, SE-751 21 Uppsala, Sweden. mehran.salehpour@angstrom.uu.se
Possnert
Göran
G
Bryhni
Helge
H
Palminger-Hallén
Ira
I
Ståhle
Lars
L
D006801:Humans; D013058:Mass Spectrometry / Q000295:instrumentation* / Q000379:methods; D010315:Particle Accelerators; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000097:blood / Q000652:urine
D004364:Pharmaceutical Preparations