title: Taenia taeniaeformis: colonic hyperplasia in heavily infected rats.
abstract: Only one study previously mentioned the involvement of colon during Taenia taeniaeformis larvae infection in rats with inconsistent occurrence of lesions. Present study aimed to determine the consistency of histopathologic changes in colonic epithelia, and the proliferation of mucosal cells through BrdU and PCNA immunohistochemistry. Results demonstrated that crypt hyperplasia of the colon was found in all infected rats, although variable in degree even in a single tissue section. Cystic cavities were frequently seen in severely hyperplastic mucosa. Proliferative zone lengths were significantly increased and PCNA positive cells were observed throughout the colonic crypt lengths at 9 but not at 6 weeks post infection. Cell proliferation involving the major types of cells in the epithelial colon was also increased in infected rats at 9 weeks post infection, with labeling indices significantly greater than the control rats throughout the BrdU time course labeling. Findings suggested that massive increases in epithelial cells and depth of colonic crypts were due to a remarkable increase in cell proliferation. The study concluded that enteropathy in the colon during T. taeniaeformis infection could be consistently observed in heavily infected rats.
authors.affiliation: Department of Medicine, Surgery and Zootechnics, College of Veterinary Medicine, Central Mindanao University, Musuan, Bukidnon 8710, Philippines.
authors.forename: Jose Trinipil
authors.initials: JT
authors.lastname: Lagapa
authors.forename: Yuzaburo
authors.initials: Y
authors.lastname: Oku
authors.forename: Masao
authors.initials: M
authors.lastname: Kamiya
mesh_terms: D000818:Animals; D001973:Bromodeoxyuridine; D003106:Colon / Q000469:parasitology / Q000473:pathology*; D006965:Hyperplasia / Q000469:parasitology / Q000473:pathology; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000469:parasitology / Q000473:pathology; D008297:Male; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D013621:Taenia / Q000472:pathogenicity*; D013622:Taeniasis / Q000469:parasitology / Q000473:pathology*
chemical_list: D018809:Proliferating Cell Nuclear Antigen; D001973:Bromodeoxyuridine