Non-septicemic melioidosis presenting as cardiac tamponade.
Melioidosis is endemic in Taiwan. It is caused by infection with Burkholderia pseudomallei. A prolonged course of oral eradication therapy to avoid relapse after an intensive intravenous therapy is recommended to treat melioidosis. Melioidosis with cardiac involvement is rare and is often combined with septicemia, for which the mortality rate is 20-60%. The initial clinical presentations of melioidosis mimic Mycobacterium tuberculosis infection, which is the most common etiology of bacterial pericarditis in Taiwan. We present a case of non-septicemic melioidosis that presented as non-suppurative cardiac tamponade and left subcarinal lymphadenopathy. Underlying diseases included hepatitis B-related liver cirrhosis and hepatocellular carcinoma. The patient was successfully treated with 2 weeks of intravenous ceftazidime and 12 weeks of oral doxycycline, trimethoprim-sulfamethoxazole, and amoxicillin/clavulanate. Melioidosis-related pericarditis should be considered in the differential diagnoses of bacterial pericarditis in Taiwan.
Chung
Hsing-Chun
HC
Division of Infectious Diseases and Division of Gastroenterology, Department of Internal Medicine, E-Da Hospital/I-Shou University, Kaohsiung County, Taiwan, Republic of China. ed102749@edah.org.tw
Lee
Ching-Tai
CT
Lai
Chung-Hsu
CH
Huang
Chun-Kai
CK
Lin
Jiun-Nong
JN
Liang
Shiou-Haur
SH
Lin
Hsi-Hsun
HH
D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000821:virology; D002305:Cardiac Tamponade / Q000209:etiology*; D003937:Diagnosis, Differential; D006509:Hepatitis B / Q000150:complications; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000821:virology; D008113:Liver Neoplasms / Q000150:complications / Q000821:virology; D008206:Lymphatic Diseases / Q000150:complications; D008297:Male; D008554:Melioidosis / Q000150:complications* / Q000188:drug therapy; D010493:Pericarditis / Q000209:etiology / Q000473:pathology
D000900:Anti-Bacterial Agents