title: Brain serotonin transporter binding of [123I]ADAM: within-subject variation between summer and winter data.
abstract: The neurotransmitter serotonin (5-HT) controls several physiological functions, and a disturbance of the 5-HT system is implicated in many psychiatric conditions. Seasonal variation has been suggested in the 5-HT system. We investigated within-subject seasonal variation in brain serotonin transporter (SERT) binding with the SERT-ligand [(123)I]ADAM and single photon emission computed tomography (SPECT) in 12 healthy individuals. No systematic variation was found in the midbrain or thalamus areas between scans done in summer and winter. Our results suggest that factors other than season are more important in causing within-subject variation of brain SERT binding between summer and winter.
authors.affiliation: Department of Clinical Physiology and Nuclear Medicine, HUSLAB/Helsinki University Central Hospital, Helsinki, Finland. anu.koskela@helsinki.fi
authors.forename: Anu
authors.initials: A
authors.lastname: Koskela
authors.forename: Tomi
authors.initials: T
authors.lastname: Kauppinen
authors.forename: Anna
authors.initials: A
authors.lastname: Keski-Rahkonen
authors.forename: Elina
authors.initials: E
authors.lastname: Sihvola
authors.forename: Jaakko
authors.initials: J
authors.lastname: Kaprio
authors.forename: Aila
authors.initials: A
authors.lastname: Rissanen
authors.forename: Aapo
authors.initials: A
authors.lastname: Ahonen
mesh_terms: D051722:ADAM Proteins / Q000378:metabolism*; D000328:Adult; D001921:Brain / Q000378:metabolism*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D011485:Protein Binding; D012621:Seasons; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*
chemical_list: D007457:Iodine Radioisotopes; D050486:Serotonin Plasma Membrane Transport Proteins; D051722:ADAM Proteins