Rearranged and unrearranged angucyclinones from Indonesian Streptomyces spp.
Two Indonesian Streptomyces strains, ICBB8309 and ICBB8415, were investigated for their ability to produce antibiotic compounds. In addition to the known antibiotics actiphenol, naramycin B, and sabaramycin, six new angucyclinones were identified. The isolation, structure elucidation and biological activities for the six new compounds are presented. The angucyclinones 7-deoxo-6-deoxy-7-hydroxy-8-O-methylrabelomycin, 1-deoxo-1-hydroxy-8-O-methylrabelomycin, and the angucycline 7-deoxo-7-hydroxy-1-O-alpha-rhamnosyl-8-O-methyltetrangulol have common angular backbones, while angucyclinone C, limamycin A, and limamycin B appear to be rearranged angucyclinones.
Fotso
Serge
S
Department of Pharmaceutical Sciences, College of Pharmacy, Corvallis, Oregon 97331-3507, USA.
Mahmud
Taifo
T
Zabriskie
T Mark
TM
Santosa
Dwi Andreas
DA
Proteau
Philip J
PJ
D000880:Anthraquinones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D007214:Indonesia; D020102:Mycobacterium smegmatis / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013302:Streptomyces / Q000737:chemistry* / Q000302:isolation & purification
D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; C510997:angucyclinone