Mechanisms and consequences of dendritic cell migration.
Dendritic cells (DCs) are critical for adaptive immunity and tolerance. Most DCs are strategically positioned as immune sentinels poised to respond to invading pathogens in tissues throughout the body. Differentiated DCs and their precursors also circulate in blood and can get rapidly recruited to sites of challenge. Within peripheral tissues, DCs collect antigenic material and then traffic to secondary lymphoid organs, where they communicate with lymphocytes to orchestrate adaptive immune responses. Hence, the migration and accurate positioning of DCs is indispensable for immune surveillance. Here, we review the molecular traffic signals that govern the migration of DCs throughout their life cycle.
Alvarez
David
D
Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
Vollmann
Elisabeth H
EH
von Andrian
Ulrich H
UH
D000818:Animals; D002465:Cell Movement; D002630:Chemotactic Factors / Q000276:immunology / Q000378:metabolism; D002633:Chemotaxis; D016207:Cytokines / Q000276:immunology / Q000378:metabolism*; D003713:Dendritic Cells / Q000276:immunology* / Q000502:physiology; D006801:Humans; D008221:Lymphoid Tissue / Q000276:immunology*; D019707:Receptors, Chemokine / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction; D013154:Spleen / Q000166:cytology / Q000276:immunology
D002630:Chemotactic Factors; D016207:Cytokines; D019707:Receptors, Chemokine
J Immunol. 1998 Aug 1;161(3):1083-6
9686565
Science. 2004 Aug 20;305(5687):1150-3
15326354
J Pathol. 1970 Jan;100(1):21-9
5470534
Nat Rev Immunol. 2003 Nov;3(11):867-78
14668803
Nat Immunol. 2003 Jun;4(6):579-85
12730692
J Immunol. 2007 Mar 1;178(5):2973-8
17312142
J Exp Med. 2004 Oct 4;200(7):847-56
15466619
J Exp Med. 2001 Aug 20;194(4):541-9
11514609
Arch Dermatol Res. 1999 Jun;291(6):357-61
10421063
J Exp Med. 1999 Feb 1;189(3):593-8
9927521
J Exp Med. 2001 Nov 5;194(9):1375-84
11696601
Immunol Cell Biol. 1994 Feb;72(1):79-86
7512535
Adv Drug Deliv Rev. 2001 Aug 23;50(1-2):3-20
11489331
EMBO J. 2004 Sep 1;23(17):3505-15
15318168
Nat Immunol. 2006 Mar;7(3):311-7
16462739
J Clin Invest. 2004 Sep;114(5):729-38
15343392
J Exp Med. 1989 Oct 1;170(4):1285-301
2794860
J Exp Med. 2007 Mar 19;204(3):489-95
17325198
Eur J Immunol. 2005 May;35(5):1342-6
15789340
Annu Rev Immunol. 2003;21:685-711
12615891
J Immunol. 1998 Apr 15;160(8):4067-73
9558117
Nature. 2004 Jan 8;427(6970):154-9
14712275
J Immunol. 2002 May 1;168(9):4361-71
11970978
Cell. 1999 Oct 1;99(1):23-33
10520991
Nat Immunol. 2004 Dec;5(12):1235-42
15516925
J Clin Invest. 2006 Nov;116(11):2935-44
17080194
J Immunol. 2000 Mar 1;164(5):2285-95
10679062
Blood. 2007 Jan 15;109(2):626-31
16985179
N Engl J Med. 2000 Oct 5;343(14):1020-34
11018170
J Immunol. 1998 Mar 1;160(5):2166-73
9498754
Nat Med. 2004 May;10(5):510-7
15098028
J Exp Med. 2005 Jul 4;202(1):135-43
15998792
Nat Biotechnol. 2005 Nov;23(11):1407-13
16258544
Immunology. 1995 Jan;84(1):31-5
7890303
Eur J Immunol. 2001 Oct;31(10):3085-93
11592085
J Immunol. 1999 Dec 1;163(11):5989-93
10570286
J Immunol. 2001 Jul 1;167(1):228-34
11418653
Immunology. 2008 Mar;123(3):438-46
17944899
Immunity. 2004 Aug;21(2):279-88
15308107
J Exp Med. 2001 Nov 5;194(9):1361-73
11696600
Proc Natl Acad Sci U S A. 2004 Jan 27;101(4):998-1003
14722354
Proc Natl Acad Sci U S A. 2007 May 15;104(20):8421-6
17485674
Cell. 2008 Feb 22;132(4):612-30
18295579
Curr Opin Immunol. 2006 Aug;18(4):503-11
16777395
J Immunol. 2000 Dec 15;165(12):6762-70
11120796
Cell Immunol. 1976 Aug;25(2):137-51
782728
J Immunol. 2005 Sep 1;175(5):2960-7
16116182
Eur J Immunol. 1998 Sep;28(9):2760-9
9754563
Nature. 2008 May 1;453(7191):51-5
18451854
Nat Immunol. 2005 Oct;6(10):1029-37
16155571
J Immunol. 2007 Mar 15;178(6):3437-46
17339438
Nat Immunol. 2003 Sep;4(9):891-8
12910265
Annu Rev Immunol. 2004;22:891-928
15032599
Arch Dermatol Res. 1997 Apr;289(5):277-84
9164638
Trends Cell Biol. 2000 Nov;10(11):466-73
11050418
J Immunol. 2000 Nov 1;165(9):4910-6
11046016
J Exp Med. 2004 Nov 15;200(10):1231-41
15534368
Immunity. 2003 Jul;19(1):71-82
12871640
J Exp Med. 2007 Dec 24;204(13):3147-56
18086865
Immunity. 2006 Dec;25(6):989-1001
17112751
J Immunol. 2001 Jan 1;166(1):361-9
11123313
Evid Based Complement Alternat Med. 2007 Mar;4(1):77-82
17342244
Annu Rev Immunol. 2007;25:381-418
17378762
Invest Ophthalmol Vis Sci. 2005 Apr;46(4):1201-7
15790880
Nat Immunol. 2006 Oct;7(10):1092-100
16951687
J Exp Med. 1997 Jun 16;185(12):2133-41
9182685
Eur J Immunol. 1998 Dec;28(12):4114-22
9862347
J Exp Med. 1988 Feb 1;167(2):646-51
3258010
Am J Respir Cell Mol Biol. 2004 Jun;30(6):761-70
14656746
J Exp Med. 1997 Dec 1;186(11):1819-29
9382881
Int Immunol. 2008 Jul;20(7):911-23
18495625
Microbes Infect. 1999 Nov;1(13):1079-84
10572310
Int Immunol. 2004 Jul;16(7):915-28
15159375
Cell. 2007 Nov 30;131(5):994-1008
18045540
J Immunol. 1993 May 1;150(9):3698-704
8473727
Proc Natl Acad Sci U S A. 1992 Feb 15;89(4):1398-402
1741395
Immunobiology. 2006;211(6-8):587-97
16920497
J Exp Med. 2003 Aug 18;198(4):615-21
12925677
J Immunol. 2007 Nov 1;179(9):5855-63
17947659
Int Immunol. 2005 Jul;17(7):943-50
15967782
J Invest Dermatol. 2008 Jun;128(6):1470-5
18185529
J Exp Med. 1999 Feb 1;189(3):447-50
9927506
J Immunol. 1997 Dec 15;159(12):6148-55
9550416
Eur J Immunol. 2000 Oct;30(10):2808-14
11069061
Am J Pathol. 2007 Oct;171(4):1249-57
17823289
Cell. 1994 Jan 28;76(2):301-14
7507411
J Immunol. 1997 Aug 15;159(4):1993-2000
9257866
Nat Immunol. 2007 Nov;8(11):1217-26
17922015
Science. 2006 Jan 6;311(5757):83-7
16322423
Blood. 2008 Jan 1;111(1):260-70
17925490
Immunity. 2005 Apr;22(4):439-50
15845449
Blood. 2002 Feb 1;99(3):946-56
11806998
Nat Rev Immunol. 2004 Jun;4(6):432-44
15173832
J Immunol. 2001 Aug 15;167(4):1862-6
11489962
J Immunol. 1994 Jul 1;153(1):256-61
8207240
Science. 2006 Jun 16;312(5780):1672-6
16778060
J Immunol. 1998 Sep 15;161(6):3096-102
9743376
Immunity. 2007 Oct;27(4):610-24
17936032
Nat Rev Immunol. 2006 Dec;6(12):907-18
17124512
Nat Cell Biol. 2006 Jun;8(6):615-22
16715077
J Exp Med. 1996 Dec 1;184(6):2417-22
8976197
Physiol Rev. 1999 Jan;79(1):181-213
9922371
Am J Physiol Lung Cell Mol Physiol. 2007 Dec;293(6):L1374-6
17934061
Semin Immunol. 2005 Aug;17(4):304-12
15946853
J Exp Med. 2005 Feb 21;201(4):509-15
15728234
J Exp Med. 2001 Oct 15;194(8):1111-22
11602640
Annu Rev Biochem. 1990;59:237-52
2197976
Annu Rev Immunol. 2005;23:127-59
15771568
J Leukoc Biol. 2007 Dec;82(6):1375-81
17709402
Immunology. 1979 Dec;38(4):797-808
93086
J Immunol. 1999 Mar 1;162(5):2472-5
10072485
Am J Pathol. 2001 Jul;159(1):237-43
11438470
Immunity. 2003 Jul;19(1):47-57
12871638
J Exp Med. 1999 Sep 6;190(5):629-38
10477548
J Exp Med. 1999 Feb 1;189(3):451-60
9927507
J Exp Med. 2007 Dec 24;204(13):3119-31
18086861
FASEB J. 2002 Apr;16(6):625-7
11919175
Blood. 2005 Feb 15;105(4):1590-7
15494425
Arch Dermatol Res. 1999 Jul-Aug;291(7-8):447-52
10482016
EMBO J. 2006 Nov 29;25(23):5560-8
17093498
J Immunol. 1995 Oct 1;155(7):3292-5
7561021
J Immunol. 2003 Apr 1;170(7):3514-21
12646612
J Exp Med. 2002 May 6;195(9):1145-54
11994419
Nat Med. 1999 Aug;5(8):919-23
10426316
Nat Rev Immunol. 2007 Jan;7(1):19-30
17170756
Cancer Res. 1999 Jan 1;59(1):56-8
9892184
J Exp Med. 1998 Jul 20;188(2):373-86
9670049
J Exp Med. 2003 Sep 1;198(5):715-24
12953093
Adv Immunol. 2007;93:265-78
17383544
Immunity. 2000 Sep;13(3):355-64
11021533
Nat Rev Immunol. 2007 Sep;7(9):678-89
17717539
Nat Immunol. 2002 Dec;3(12):1135-41
12415265
Nat Immunol. 2004 Dec;5(12):1243-50
15543150
J Clin Invest. 2007 Jan;117(1):185-94
17200718
J Immunol. 2001 Mar 15;166(6):3672-7
11238606
Annu Rev Cell Dev Biol. 2005;21:581-603
16212508
Nat Immunol. 2006 Mar;7(3):265-73
16444257
J Immunol. 2002 May 15;168(10):5117-23
11994465
J Exp Med. 1990 May 1;171(5):1753-71
2185332
Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12694-9
11070085
Eur J Immunol. 2006 Oct;36(10):2781-94
16981228
J Exp Med. 2005 Sep 5;202(5):687-96
16147979
Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10871-6
18663225
J Exp Med. 2007 Jan 22;204(1):171-80
17190836
J Immunol. 1998 Sep 1;161(5):2501-8
9725249
Annu Rev Immunol. 2000;18:767-811
10837075
J Anat. 1986 Oct;148:25-46
3693091
J Exp Med. 2007 Oct 1;204(10):2349-62
17846148
J Invest Dermatol. 1992 Nov;99(5):109S-110S
1431199
J Immunol. 1999 Apr 15;162(8):4567-75
10201996
J Immunol. 2000 Mar 15;164(6):2978-86
10706685
J Immunol. 2007 Feb 15;178(4):2000-7
17277103
J Immunol. 1989 Oct 15;143(8):2431-8
2571637
Nature. 2007 Sep 27;449(7161):419-26
17898760
J Immunol. 2000 Oct 1;165(7):4062-8
11034417
Science. 2007 Aug 3;317(5838):666-70
17673663
Immunity. 2005 May;22(5):643-54
15894281
Nat Rev Immunol. 2005 Dec;5(12):953-64
16322748
J Exp Med. 2001 Jan 15;193(2):207-18
11148224
Trends Immunol. 2005 Jul;26(7):360-6
15978522
Mol Cell Biol. 2000 Jun;20(11):4106-14
10805752
J Exp Med. 2003 Oct 6;198(7):1023-34
14530375
Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6347-52
17404233
Eur J Immunol. 2002 Jul;32(7):2074-83
12115629
J Exp Med. 2006 Nov 27;203(12):2763-77
17116732
J Exp Med. 1999 Feb 15;189(4):627-36
9989977
Nat Immunol. 2007 Nov;8(11):1207-16
17922016
J Immunol. 2005 Jan 1;174(1):244-51
15611246
Nat Immunol. 2000 Oct;1(4):353-7
11017109
Nat Immunol. 2007 Jun;8(6):578-83
17450143
Nat Rev Immunol. 2002 Nov;2(11):872-80
12415310
J Exp Med. 1999 Oct 18;190(8):1183-8
10523616
J Immunol. 2002 Mar 1;168(5):2139-46
11859099
J Exp Med. 2000 Sep 4;192(5):705-18
10974036
J Leukoc Biol. 2004 Feb;75(2):275-85
14597730
J Exp Med. 2007 Dec 24;204(13):3133-46
18086862
Nature. 1993 Jan 7;361(6407):82-5
8421498
J Immunol. 2007 Oct 1;179(7):4616-25
17878359