Cancer cell metabolism: Warburg and beyond.
Described decades ago, the Warburg effect of aerobic glycolysis is a key metabolic hallmark of cancer, yet its significance remains unclear. In this Essay, we re-examine the Warburg effect and establish a framework for understanding its contribution to the altered metabolism of cancer cells.
Hsu
Peggy P
PP
Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology Department of Biology, Cambridge, MA 02142, USA.
Sabatini
David M
DM
D000818:Animals; D053898:Biosynthetic Pathways; D019069:Cell Respiration; D004734:Energy Metabolism; D006019:Glycolysis; D006801:Humans; D009369:Neoplasms / Q000378:metabolism*