A case report of nephrotic syndrome due to collapsing focal segmental glomerulosclerosis treated with low-density lipoprotein apheresis.
We herein report the case of a 73-year-old woman with steroid and cyclosporine resistant collapsing focal segmental glomerulosclerosis (FSGS) whose refractory proteinuria and hypoproteinemia were controlled with low-density lipoprotein apheresis (LDL-A). She was initially treated with steroid therapy, including methylprednisolone pulse and cyclosporine therapy. However, her hypoproteinemia, accompanied with renal insufficiency, persisted despite these therapies. We treated her using LDL-A and found improvement in her urine protein excretion, hyperlipidemia, hypoproteinemia, and renal function as a result of this treatment. This suggests that LDL-A may therefore be an effective therapy for nephrotic syndrome due to collapsing FSGS.
Miyazono
Motoaki
M
Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan. Email: miyazono@cc.saga-u.ac.jp
Tomiyoshi
Yoshiyuki
Y
Kishi
Tomoya
T
Ikeda
Yuji
Y
Sakemi
Takanobu
T
Sanai
Toru
T
Node
Koichi
K
D000368:Aged; D001781:Blood Component Removal / Q000379:methods*; D016572:Cyclosporine / Q000627:therapeutic use; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications / Q000628:therapy*; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008077:Lipoproteins, LDL / Q000097:blood; D008775:Methylprednisolone / Q000008:administration & dosage; D009404:Nephrotic Syndrome / Q000209:etiology / Q000628:therapy*
D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D008077:Lipoproteins, LDL; D016572:Cyclosporine; D008775:Methylprednisolone