title: Phomoeuphorbins A-D, azaphilones from the fungus Phomopsis euphorbiae.
abstract: Four azaphilones, named phomoeuphorbins A-D (1-4) were isolated from cultures of Phomopsis euphorbiae, an endophytic fungus isolated from Trewia nudiflora. Structures of 1-4 were established on the basis of spectroscopic analyses, including application of 2D NMR spectroscopic techniques. Phomoeuphorbins A and C exhibited very weak inhibitory activities against HIV replication in C8166 cells in vitro.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.
authors.forename: Bu-Zhu
authors.initials: BZ
authors.lastname: Yu
authors.forename: Gao-Hong
authors.initials: GH
authors.lastname: Zhang
authors.forename: Zhi-Zhi
authors.initials: ZZ
authors.lastname: Du
authors.forename: Yong-Tang
authors.initials: YT
authors.lastname: Zheng
authors.forename: Jian-Chu
authors.initials: JC
authors.lastname: Xu
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Luo
mesh_terms: D001578:Benzopyrans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D005658:Fungi / Q000737:chemistry*; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010860:Pigments, Biological / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects
chemical_list: D001578:Benzopyrans; D010860:Pigments, Biological; C494154:azaphilone; C535021:phomoeuphorbin A; C535022:phomoeuphorbin C