title: Synthesis and antiviral evaluation of a seven-membered sugar ring nucleoside analog, 9-(5-deoxy-beta-D-allo-septanosyl)-adenine.
abstract: The first example of a nucleoside analogue bearing a 5'-deoxy-beta-D-allo-septanose as the sugar moiety was synthesized and evaluated as a potential inhibitor of several virus replication.
authors.affiliation: Idenix Pharmaceuticals: Medicinal Chemistry Laboratory, Cap Gamma, 1682 Rue de la Valsière, 34189 Montpellier Cedex 4, France.
authors.forename: Gwenaëlle
authors.initials: G
authors.lastname: Sizun
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Griffon
authors.forename: Ludovic
authors.initials: L
authors.lastname: Griffe
authors.forename: David
authors.initials: D
authors.lastname: Dukhan
authors.forename: Richard
authors.initials: R
authors.lastname: Storer
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Sommadossi
authors.forename: Anna Giulia
authors.initials: AG
authors.lastname: Loi
authors.forename: Chiara
authors.initials: C
authors.lastname: Musiu
authors.forename: Barbara
authors.initials: B
authors.lastname: Poddesu
authors.forename: Alessandra
authors.initials: A
authors.lastname: Cadeddu
authors.forename: Maura
authors.initials: M
authors.lastname: Fanti
authors.forename: Nadia
authors.initials: N
authors.lastname: Boscu
authors.forename: Fabiola
authors.initials: F
authors.lastname: Bassetti
authors.forename: Michel
authors.initials: M
authors.lastname: Liuzzi
authors.forename: Gilles
authors.initials: G
authors.lastname: Gosselin
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: C541635:9-(5-deoxyseptanosyl)adenine; D000998:Antiviral Agents; D000241:Adenosine