Influences of gender on the interaction between sympathetic nerve traffic and central adiposity.
BACKGROUND
Sympathetic activation promotes insulin resistance and arterial hypertension with increasing adiposity. A difference in the relationship between adiposity and sympathetic activity between women and men could contribute to the known gender difference in cardiovascular disease risk.


OBJECTIVE
We tested whether muscle sympathetic nerve activity (MSNA) is correlated differently with waist circumference, waist to hip ratio (WHR), and body mass index (BMI) in women and men.


METHODS
We pooled data from two microneurography centers (Berlin, Germany; Gdansk, Poland) for a cross-sectional study.


METHODS
We studied 111 normotensive, healthy Caucasian subjects (70 males and 41 females). Age ranged between 19 and 62 yr and BMI ranged between 18 and 40 kg/m(2).


METHODS
No intervention was applied during the study.


METHODS
Supine heart rate, blood pressure, and MSNA were recorded after at least 30 min rest.


RESULTS
MSNA in bursts per minute was age dependent in both sexes [r (male) = 0.56, r (female) = 0.34, P < 0.01]. Controlling for waist and hip circumferences, age dependence remained highly significant in men (r = 0.43) and women (r = 0.43). Adjusting for age, in men, waist circumference (r = 0.29), WHR (r = 0.39), and BMI (r = 0.31) were predictive for MSNA and directly correlated (P < 0.01) but not in women. Adjusting for BMI, in men, only WHR (r = 0.40) remained predictive for MSNA.


CONCLUSIONS
These data support the hypothesis of a gender difference in the regulation of the sympathetic nervous system, in which MSNA mainly relates to WHR in men but not women. The phenomenon may contribute to the sexual dimorphism in cardiovascular disease risk.
Tank
Jens
J
Institute of Clinical Pharmacology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany.
Heusser
Karsten
K
Diedrich
Andre
A
Hering
Dagmara
D
Luft
Friedrich C
FC
Busjahn
Andreas
A
Narkiewicz
Krzysztof
K
Jordan
Jens
J
D050154:Adiposity / Q000502:physiology*; D000328:Adult; D000375:Aging / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000294:innervation / Q000502:physiology; D012727:Sex Characteristics; D013564:Sympathetic Nervous System / Q000502:physiology*; D055105:Waist Circumference
Am J Physiol. 1996 Feb;270(2 Pt 1):E363-6
8779960
Clin Pharmacol Ther. 2006 May;79(5):500-8
16678551
Hypertension. 2000 Jul;36(1):26-32
10904008
Am J Cardiol. 1994 Mar 1;73(7):460-8
8141087
Eur Heart J. 2008 Apr;29(7):932-40
18334475
Hypertension. 2003 Mar;41(3 Pt 2):763-7
12623993
J Hypertens. 2007 Jul;25(7):1411-9
17563563
Circulation. 2003 Jun 17;107(23):2949-54
12796139
Int J Obes Relat Metab Disord. 1997 Nov;21(11):1053-7
9368830
Hypertension. 1993 Apr;21(4):498-503
8458648
Hypertension. 2000 Oct;36(4):531-7
11040231
J Clin Endocrinol Metab. 1999 Jul;84(7):2270-4
10404789
Circulation. 1998 Aug 25;98(8):772-6
9727547
Arch Intern Med. 1995 Dec 11-25;155(22):2443-8
7503603
Circulation. 1997 Nov 18;96(10):3423-9
9396437
J Appl Physiol (1985). 1995 Mar;78(3):802-6
7775321
Int J Obes Relat Metab Disord. 2004 Aug;28(8):1018-25
15197408
Pharmacol Toxicol. 1993 Nov;73(5):243-53
8115306
Am J Physiol. 1997 Jun;272(6 Pt 1):E976-80
9227440
Acta Physiol Scand. 2003 Mar;177(3):337-43
12609004
J Clin Invest. 1993 Oct;92(4):1730-5
8408625
J Hypertens. 2004 Dec;22(12):2363-9
15614031
Circulation. 2002 Nov 12;106(20):2533-6
12427647
Obesity (Silver Spring). 2007 Jul;15(7):1694-701
17636087
Hypertension. 2005 Apr;45(4):522-5
15767469
Braz J Med Biol Res. 2001 Apr;34(4):475-8
11285458
J Clin Endocrinol Metab. 2003 Oct;88(10):4955-9
14557480
Am J Physiol Heart Circ Physiol. 2004 Jul;287(1):H414-8
14988078
Diabetes Obes Metab. 2006 Nov;8(6):603-10
17026484
Blood Press. 2006;15(2):68-70
16754268
J Neurosci. 2003 Jul 9;23(14):5998-6004
12853417