title: Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapy.
abstract: Patients with inefficient CD4+ T-cell recovery on virogically suppressive highly active antiretroviral therapy constitute a major clinical hurdle given the threat of HIV/AIDS disease progression. We show heightened circulating lipopolysaccharide associated with plasma enterobacterial DNA and highly activated Ki67+CD4+CD8+ in 24 immunologic-nonresponders (CD4+ T-cell < or = 200; HIV-RNA < or = 50) compared with 11 full responders (CD4+ T-cell > or= 400; HIV-RNA < or = 50). These data provide novel insight into INRs pathogenesis, since they correlate augmented systemic translocation of microbial bioproducts with T-cell hyperactivation.
authors.affiliation: Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases, San Paolo Hospital, University of Milan, Milan, Italy. giulia.marchetti@unimi.it
authors.forename: Giulia
authors.initials: G
authors.lastname: Marchetti
authors.forename: Giusi M
authors.initials: GM
authors.lastname: Bellistrì
authors.forename: Elisa
authors.initials: E
authors.lastname: Borghi
authors.forename: Camilla
authors.initials: C
authors.lastname: Tincati
authors.forename: Stefania
authors.initials: S
authors.lastname: Ferramosca
authors.forename: Maria
authors.initials: M
authors.lastname: La Francesca
authors.forename: Giulia
authors.initials: G
authors.lastname: Morace
authors.forename: Andrea
authors.initials: A
authors.lastname: Gori
authors.forename: Antonella D'Arminio
authors.initials: AD
authors.lastname: Monforte
mesh_terms: D000328:Adult; D000368:Aged; D023241:Antiretroviral Therapy, Highly Active; D018988:Bacterial Translocation / Q000276:immunology*; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D004269:DNA, Bacterial / Q000097:blood; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology* / Q000382:microbiology*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology; D008875:Middle Aged
chemical_list: D004269:DNA, Bacterial