title: A click chemistry approach towards nucleic acid major groove functionalization.
abstract: A synthetic strategy towards new aromatic nucleoside derivatives introducing additional aromatic functionality placed in the major groove of a modified DNA duplex is presented. The functionalities are introduced using Click Chemistry conditions and found to increase the overall duplex stability.
authors.affiliation: Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, 5230 Odense M, Denmark.
authors.forename: Nicolai K
authors.initials: NK
authors.lastname: Andersen
authors.forename: Lucie
authors.initials: L
authors.lastname: Spácilová
authors.forename: Michael D
authors.initials: MD
authors.lastname: Jensen
authors.forename: Petr
authors.initials: P
authors.lastname: Kocalka
authors.forename: Frank
authors.initials: F
authors.lastname: Jensen
authors.forename: Poul
authors.initials: P
authors.lastname: Nielsen
mesh_terms: D001671:Biochemistry / Q000379:methods; D004247:DNA / Q000737:chemistry*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D011741:Pyrimidine Nucleosides; D004247:DNA