title: Forensic toxicological implication of an autopsy case of mixed drug overdose involving clomipramine, chlorpromazine and flunitrazepam.
abstract: A case of fatal poisoning involving clomipramine, chlorpromazine and flunitrazepam is presented. Quantitative toxicological analysis showed that the concentrations of clomipramine, chlorpromazine and 7-aminoflunitrazepam (a metabolite of flunitrazepam) in the femoral blood were 3.24 microg/ml, 0.36 Kg/ml and 0.61 microg/ml, respectively, and large amounts of drugs were also detected from the stomach contents. We concluded that the cause of death was due to the combined use of clomipramine, chlorpromazine and flunitrazepam.
authors.affiliation: Department of Legal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. kinochin@hyo-med.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kinoshita
authors.forename: Minori
authors.initials: M
authors.lastname: Nishiguchi
authors.forename: Shogo
authors.initials: S
authors.lastname: Kasuda
authors.forename: Motonori
authors.initials: M
authors.lastname: Takahashi
authors.forename: Harumi
authors.initials: H
authors.lastname: Ouchi
authors.forename: Takako
authors.initials: T
authors.lastname: Minami
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Matsui
authors.forename: Takehiko
authors.initials: T
authors.lastname: Yamamura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Motomura
authors.forename: Nao
authors.initials: N
authors.lastname: Ohtsu
authors.forename: Shie
authors.initials: S
authors.lastname: Yoshida
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Adachi
authors.forename: Takehiko
authors.initials: T
authors.lastname: Ohta
authors.forename: Motoo
authors.initials: M
authors.lastname: Komeda
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Ameno
authors.forename: Shigeru
authors.initials: S
authors.lastname: Hishida
mesh_terms: D000328:Adult; D002746:Chlorpromazine / Q000032:analysis / Q000506:poisoning*; D002997:Clomipramine / Q000032:analysis / Q000506:poisoning*; D005260:Female; D005445:Flunitrazepam / Q000032:analysis / Q000506:poisoning*; D006801:Humans; D011619:Psychotropic Drugs / Q000032:analysis / Q000506:poisoning*; D013405:Suicide
chemical_list: D011619:Psychotropic Drugs; D005445:Flunitrazepam; D002997:Clomipramine; D002746:Chlorpromazine