Optimal wavelet transform for the detection of microaneurysms in retina photographs.
In this paper, we propose an automatic method to detect microaneurysms in retina photographs. Microaneurysms are the most frequent and usually the first lesions to appear as a consequence of diabetic retinopathy. So, their detection is necessary for both screening the pathology and follow up (progression measurement). Automating this task, which is currently performed manually, would bring more objectivity and reproducibility. We propose to detect them by locally matching a lesion template in subbands of wavelet transformed images. To improve the method performance, we have searched for the best adapted wavelet within the lifting scheme framework. The optimization process is based on a genetic algorithm followed by Powell's direction set descent. Results are evaluated on 120 retinal images analyzed by an expert and the optimal wavelet is compared to different conventional mother wavelets. These images are of three different modalities: there are color photographs, green filtered photographs, and angiographs. Depending on the imaging modality, microaneurysms were detected with a sensitivity of respectively 89.62%, 90.24%, and 93.74% and a positive predictive value of respectively 89.50%, 89.75%, and 91.67%, which is better than previously published methods.
Quellec
Gwénolé
G
INSTITUT TELECOM, TELECOM Bretag, F-29200 Brest, France.
Lamard
Mathieu
M
Josselin
Pierre Marie
PM
Cazuguel
Guy
G
Cochener
Béatrice
B
Roux
Christian
C
D000465:Algorithms; D000783:Aneurysm / Q000473:pathology*; D001185:Artificial Intelligence; D003930:Diabetic Retinopathy / Q000473:pathology*; D005451:Fluorescein Angiography / Q000379:methods; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods*; D010781:Photography / Q000379:methods*; D015203:Reproducibility of Results; D012161:Retinal Artery / Q000473:pathology*; D042262:Retinoscopy / Q000379:methods*; D012680:Sensitivity and Specificity
IEEE Trans Med Imaging. 2000 Mar;19(3):203-10
10875704
Ophthalmology. 1997 Feb;104(2):252-60
9052629
Ophthalmology. 2003 Sep;110(9):1677-82
13129861
IEEE Trans Med Imaging. 2006 Sep;25(9):1223-32
16967807
Pharmacoeconomics. 1995;8 Suppl 1:33-9
10159001
Med Biol Eng Comput. 2002 Jan;40(1):2-13
11954703
Conf Proc IEEE Eng Med Biol Soc. 2004;2006:329-32
17271677
Diabet Med. 2000 Aug;17(8):588-94
11073180
IEEE Trans Med Imaging. 1989;8(3):263-9
18230524
IEEE Trans Med Imaging. 2005 May;24(5):584-92
15889546
Comput Methods Programs Biomed. 2000 Jul;62(3):165-75
10837904
Diabet Med. 2002 Feb;19(2):105-12
11874425
IEEE Trans Med Imaging. 2001 Jul;20(7):595-604
11465466
IEEE Trans Image Process. 2001;10(7):1010-9
18249674
Ophthalmology. 1984 Jan;91(1):1-9
6709312