Non-cannabinoid constituents from a high potency Cannabis sativa variety.
Six new non-cannabinoid constituents were isolated from a high potency Cannabis sativa L. variety, namely 5-acetoxy-6-geranyl-3-n-pentyl-1,4-benzoquinone (1), 4,5-dihydroxy-2,3,6-trimethoxy-9,10-dihydrophenanthrene (2), 4-hydroxy-2,3,6,7-tetramethoxy-9,10-dihydrophenanthrene (3), 4,7-dimethoxy-1,2,5-trihydroxyphenanthrene (4), cannflavin C (5) and beta-sitosteryl-3-O-beta-d-glucopyranoside-2'-O-palmitate (6). In addition, five known compounds, alpha-cannabispiranol (7), chrysoeriol (8), 6-prenylapigenin (9), cannflavin A (10) and beta-acetyl cannabispiranol (11) were identified, with 8 and 9 being reported for the first time from cannabis. Some isolates displayed weak to strong antimicrobial, antileishmanial, antimalarial and anti-oxidant activities. Compounds 2-4 were inactive as analgesics.
Radwan
Mohamed M
MM
National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
Elsohly
Mahmoud A
MA
Slade
Desmond
D
Ahmed
Safwat A
SA
Wilson
Lisa
L
El-Alfy
Abir T
AT
Khan
Ikhlas A
IA
Ross
Samir A
SA
D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000302:isolation & purification / Q000494:pharmacology; D001688:Biological Products / Q000302:isolation & purification / Q000494:pharmacology*; D002188:Cannabis / Q000737:chemistry*; D047309:Flavones / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure
D000700:Analgesics; D000890:Anti-Infective Agents; D000962:Antimalarials; D000975:Antioxidants; D000981:Antiprotozoal Agents; D001688:Biological Products; D047309:Flavones
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