An oncogenic role for the multiple endocrine neoplasia type 1 gene in prostate cancer.
Prostate cancer is the second leading cause of cancer related deaths in US men, largely because of metastasis, which is ultimately fatal. A better understanding of metastasis biology will lead to improved prognostication and therapeutics. We previously reported 11q13.1 gain was independently predictive of recurrence after radical prostatectomy. Multiple endocrine neoplasia I (MEN1) maps to this region of copy number gain in aggressive prostate tumors and was shown to be the only gene at this locus at increased expression in prostate cancer. Here, we demonstrate an oncogenic role for MEN1 in prostate cancer using a variety of independent assays.
Paris
P L
PL
Department of Urology, University of California at San Francisco Comprehensive Cancer Center, UCSF, San Francisco, CA 94143, USA.
Sridharan
S
S
Hittelman
A B
AB
Kobayashi
Y
Y
Perner
S
S
Huang
G
G
Simko
J
J
Carroll
P
P
Rubin
M A
MA
Collins
C
C
D014408:Biomarkers, Tumor / Q000235:genetics*; D045744:Cell Line, Tumor; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D011471:Prostatic Neoplasms / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D034741:RNA, Small Interfering; D020133:Reverse Transcriptase Polymerase Chain Reaction; D046888:Tissue Array Analysis
D014408:Biomarkers, Tumor; C105373:MEN1 protein, human; D011518:Proto-Oncogene Proteins; D034741:RNA, Small Interfering
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