Normalization of 14-3-3 in CJD.
We report on a 47-year-old woman with autopsy proven Creutzfeldt-Jakob disease (CJD), who had a positive initial 14-3-3 test but a subsequent negative test under pharmacologic suppression of the periodic epileptiform discharges on EEG. Multiple factors associated with a subsequent 14-3-3 test becoming negative are known. However none of these circumstances were applicable to our patient. This case history suggests sedative therapy in CJD may induce false negative 14-3-3 testing. This appears to be a relevant finding, since the differential diagnosis between non-convulsive status epilepticus and CJD is not always evident in the initial stage of the disease and some patients with CJD present with seizures.
Schrooten
Maarten
M
Department of Neurology, University of Leuven, Belgium. maarten.schrooten@uzleuven.be
De Vooght
Wouter
W
Weckhuysen
Sarah
S
Van Paesschen
Wim
W
Van Damme
Philip
P
D048948:14-3-3 Proteins / Q000134:cerebrospinal fluid*; D000927:Anticonvulsants / Q000627:therapeutic use; D001883:Borderline Personality Disorder / Q000150:complications; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D016292:Procedural Sedation / Q000009:adverse effects*; D007562:Creutzfeldt-Jakob Syndrome / Q000134:cerebrospinal fluid* / Q000150:complications / Q000175:diagnosis*; D004569:Electroencephalography; D005189:False Positive Reactions; D001068:Feeding and Eating Disorders / Q000150:complications; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D015151:Immunoblotting; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D013001:Somatoform Disorders / Q000150:complications; D013226:Status Epilepticus / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology
D048948:14-3-3 Proteins; D000927:Anticonvulsants; C482982:YWHAB protein, human