title: Transcriptional and epigenetic regulations of embryonic stem cells.
abstract: Embryonic stem cells (ESCs) are characterized by their broad developmental potential and the capacity to self-renew. The advent of high-throughput technologies has facilitated genome-wide studies of transcriptional network, resulting in an ever-increasing repertoire of transcription factors implicated in the maintenance of the embryonic stem cell state. While the transcriptional circuitry continues to expand, epigenetic regulation has also gained attention as an important process in stem cell function. Herein, we discuss the recent advancements made in understanding the transcriptional and epigenetic regulations of embryonic stem cells.
authors.affiliation: Gene Regulation Laboratory, Genome Institute of Singapore, Singapore 138672, Singapore.
authors.forename: Jia-Hui
authors.initials: JH
authors.lastname: Ng
authors.forename: Jian-Chien Dominic
authors.initials: JC
authors.lastname: Heng
authors.forename: Yuin-Han
authors.initials: YH
authors.lastname: Loh
authors.forename: Huck-Hui
authors.initials: HH
authors.lastname: Ng
mesh_terms: D019175:DNA Methylation; D053595:Embryonic Stem Cells / Q000502:physiology*; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase; D063146:Polycomb-Group Proteins; D011496:Protein Methyltransferases / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D063146:Polycomb-Group Proteins; D012097:Repressor Proteins; D000076983:Histone Methyltransferases; D011496:Protein Methyltransferases; D011495:Histone-Lysine N-Methyltransferase