Nucleosides with 1,4-dioxane as sugar moiety.
A synthetic route towards novel nucleosides with 1,4- dioxane as the sugar moiety has been developed. The dioxane moiety features a second anomeric center, which has been phosphitylated giving a diastereomeric mixture of the corresponding phosphoramidites.
Madsen
Andreas Stahl
AS
Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark. asm@ifk.sdu.dk
Langkjaer
Niels
N
Wengel
Jesper
J
D004146:Dioxanes / Q000737:chemistry*; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D009943:Organophosphorus Compounds / Q000737:chemistry; D013237:Stereoisomerism
D004146:Dioxanes; D009705:Nucleosides; D009943:Organophosphorus Compounds; C434331:phosphoramidite; C025223:1,4-dioxane