title: The frequency of sacroiliitis in familial Mediterranean fever and the role of HLA-B27 and MEFV mutations in the development of sacroiliitis.
abstract: The objective of this study was to investigate the frequency of sacroiliitis in familial Mediterranean fever (FMF) patients and the role of HLA-B27 and MEFV mutations in the development of sacroiliitis. The study group consisted of 256 FMF patients (male 128, female 128, mean age 27.2 +/- 6.3 years). After evaluation of the medical records, 70 patients (27.4%) were determined to have one or more of musculoskeletal manifestations. Sacroiliitis was determined in 18 (32.7%) FMF patients. The frequency of sacroiliitis among all FMF patients was found to be 7%. HLA-B27 was 47% and 6.3% in FMF patients with and without sacroiliitis, respectively. The frequency of M694V mutations in FMF patients with sacroiliitis was 93.7%. Sacroiliitis may be seen more frequently in FMF patients than expected. HLA-B27 positivity and/or M694V mutation may play a role in the development of sacroiliitis and the severity of seronegative spondyloarthropathy.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Eskişehir Osmangazi University, Eskişehir, Turkey.
authors.forename: Timuçin
authors.initials: T
authors.lastname: Kaşifoğlu
authors.forename: Cüneyt
authors.initials: C
authors.lastname: Calişir
authors.forename: Döndü U
authors.initials: DU
authors.lastname: Cansu
authors.forename: Cengiz
authors.initials: C
authors.lastname: Korkmaz
mesh_terms: D000293:Adolescent; D000328:Adult; D003598:Cytoskeletal Proteins / Q000235:genetics*; D010505:Familial Mediterranean Fever / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D005260:Female; D015796:HLA-B27 Antigen / Q000235:genetics*; D006304:Health Status; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D017354:Point Mutation; D000071198:Pyrin; D011859:Radiography; D012189:Retrospective Studies; D012446:Sacroiliac Joint / Q000000981:diagnostic imaging* / Q000503:physiopathology; D012720:Severity of Illness Index; D013167:Spondylitis, Ankylosing / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics; D055815:Young Adult
chemical_list: D003598:Cytoskeletal Proteins; D015796:HLA-B27 Antigen; C000604192:MEFV protein, human; D000071198:Pyrin
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