title: [Gamma-glytamiltransferase activity and cardiovascular diseases (ischemic heart disease and cerebral stroke)].
abstract: To investigate association between gamma-glytamiltransferase levels and the development of CVD. The data were taken from materials of the epidemiological study " Determinants of cardiovascular disease in Eastern Europe " , the HAPPIE project. We investigated representative samples from non-organized population of men and women 45 - 69 years old living in Novosibirsk - 9361 subjects (4275 men and 5086 women). The program of study included: questionnaire of previous CVD, smoking status and alcohol consumption; two blood pressure measurements; anthropometry, biochemical analysis (gamma-glytamiltransferase, total cholesterol, HDL cholesterol, and triglycerides) and rest ECG. Among all subjects we distinguished three groups: first - patients with diagnosed ischemic heart disease (angina pectoris or myocardial infarction) and without previous cerebral stroke; second - patients with previous cerebral stroke (without ischemic heart disease); third - patients without previous ischemic heart disease and cerebral stroke (control group). We revealed reliable data on sex-dependent difference of gamma-glytamiltransferase activity: men have higher gamma-glytamiltransferase activity compared with women in all age groups. Subjects who didn t take alcoholic drinks during the last year have noticeably lower gamma-glytamiltransferase level than those who took alcoholic drinks during that period. Gamma-glytamiltransferase activity was higher both in men and women in group with ischemic heart disease, than in control group. We did not reveal difference in gamma-glytamiltransferase activity between groups with cerebral stroke and control group. The similar patterns were revealed in subjects who didn't take alcoholic drinks during the last year.
authors.forename: Iu P
authors.initials: IuP
authors.lastname: Nikitin
authors.forename: S V
authors.initials: SV
authors.lastname: Burakov
authors.forename: G I
authors.initials: GI
authors.lastname: Simonova
authors.forename: S K
authors.initials: SK
authors.lastname: Maliutina
authors.forename: L V
authors.initials: LV
authors.lastname: Shcherbakova
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000201:enzymology* / Q000453:epidemiology*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000201:enzymology / Q000453:epidemiology; D018384:Oxidative Stress; D015995:Prevalence; D012426:Russia / Q000453:epidemiology; D012720:Severity of Illness Index; D020521:Stroke / Q000175:diagnosis / Q000201:enzymology / Q000453:epidemiology; D005723:gamma-Glutamyltransferase / Q000378:metabolism / Q000502:physiology*
chemical_list: D005723:gamma-Glutamyltransferase