Early efficacy of silodosin in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia.
OBJECTIVE
To evaluate the early efficacy of the alpha(1A)-adrenoceptor selective drug, silodosin, for the treatment of lower urinary tract symptoms suggestive of benign prostatic hyperplasia.


METHODS
A total of 68 patients with an International Prostate Symptom Score (IPSS) of >==8 and a Quality of Life (QOL) index of >==2 were included. Changes in the IPSS and QOL index were evaluated before and after 1, 2, 3, 4, 5, 6, 7, 14, and 28 days of twice daily oral administration of 4 mg silodosin. Next, changes in IPSS subscores as well as voiding, storage, and post micturition symptoms were assessed. Changes in total IPSS based on symptom severity were also determined.


RESULTS
Total IPSS and QOL index improved significantly from 19.38 +/- 7.46, 4.68 +/- 1.07 at baseline to 15.81 +/- 7.40, 4.22 +/- 1.30 at day 1. The subscores of voiding, storage, and post micturition symptoms were significantly decreased from 8.93 +/- 3.95, 7.97 +/- 3.88, and 2.49 +/- 1.70 at baseline to 7.28 +/- 4.09, 6.52 +/- 3.47, and 2.02 +/- 1.56 at day 1, respectively. This trend continued throughout the study. Regardless of severity, total IPSS were significantly decreased at day 1 and maintained throughout the study.


CONCLUSIONS
Silodosin may be considered a promising treatment for benign prostatic hyperplasia/lower urinary tract symptom patients.
Takao
Tetsuya
T
Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Tsujimura
Akira
A
Kiuchi
Hiroshi
H
Matsuoka
Yasuhiro
Y
Miyagawa
Yasushi
Y
Nonomura
Norio
N
Iwasa
Atsushi
A
Kameoka
Hiroshi
H
Kuroda
Hideya
H
Matsumiya
Kiyomi
K
Uchida
Kinya
K
Yoshimura
Kazuhiro
K
Okuyama
Akihiko
A
D018674:Adrenergic Antagonists / Q000627:therapeutic use*; D000368:Aged; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D008297:Male; D011470:Prostatic Hyperplasia / Q000150:complications*; D053448:Prostatism / Q000188:drug therapy* / Q000209:etiology*
D018674:Adrenergic Antagonists; D007211:Indoles; C095285:silodosin