title: Intravenous sedation with low-dose dexmedetomidine: its potential for use in dentistry.
abstract: This study investigated the physiologic and sedative parameters associated with a low-dose infusion of dexmedetomidine (Dex). Thirteen healthy volunteers were sedated with Dex at a loading dose of 6 mcg/kg/h for 5 minutes and a continuous infusion dose of 0.2 mcg/kg/h for 25 minutes. The recovery process was observed for 60 minutes post infusion. The tidal volume decreased significantly despite nonsignificant changes in respiratory rate, minute ventilation, oxygen saturation, and end-tidal carbon dioxide. The mean arterial pressure and heart rate also decreased significantly but within clinically acceptable levels. Amnesia to pin prick was present in 69% of subjects. A Trieger dot test plot error ratio did not show a significant change at 30 minutes post infusion despite a continued significant decrease in bispectral index. We conclude that sedation with a low dose of Dex appears to be safe and potentially efficacious for young healthy patients undergoing dental procedures.
authors.affiliation: Department of Dental Anesthesiology, Ohu University School of Dentistry, Fukushima, Japan. maromaro@ce.mbn.or.jp
authors.forename: Sachie
authors.initials: S
authors.lastname: Ogawa
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Seino
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ito
authors.forename: Shinya
authors.initials: S
authors.lastname: Yamazaki
authors.forename: Steven
authors.initials: S
authors.lastname: Ganzberg
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Kawaai
mesh_terms: D000328:Adult; D000647:Amnesia / Q000139:chemically induced; D000762:Anesthesia Recovery Period; D000766:Anesthesia, Dental / Q000379:methods*; D001775:Blood Circulation / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D016292:Procedural Sedation / Q000379:methods*; D020927:Dexmedetomidine / Q000008:administration & dosage / Q000494:pharmacology*; D004569:Electroencephalography / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000494:pharmacology*; D007262:Infusions, Intravenous; D010865:Pilot Projects; D012119:Respiration / Q000187:drug effects; D055815:Young Adult
chemical_list: D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine
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