Type I interferon-associated cytotoxic inflammation in cutaneous lupus erythematosus.
Inappropriate activation of innate immune mechanisms, in particular of the type I interferon (IFN) system, is regarded to play an important role in the pathogenesis of lupus erythematosus (LE). Type I IFN serum levels have been shown to correlate with the disease activity in systemic LE and additionally play a proinflammatory role in the development of LE skin lesions. Recent studies demonstrated a close morphological association between the expression pattern of IFN-inducible chemokines (MxA, CXCL10) and typical histological features of cutaneous LE. These and other studies suggest that a complex network of IFN-associated cytokines, chemokines and adhesion molecules orchestrates and promotes tissue injury observed in LE skin.
Wenzel
Joerg
J
Department of Dermatology, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany. joerg.wenzel@ukb.uni-bonn.de
Zahn
Sabine
S
Bieber
Thomas
T
Tüting
Thomas
T
D000818:Animals; D018925:Chemokines / Q000276:immunology / Q000378:metabolism; D003602:Cytotoxicity, Immunologic; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation; D007370:Interferon Type I / Q000276:immunology* / Q000378:metabolism; D008178:Lupus Erythematosus, Cutaneous / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000378:metabolism; D051193:Toll-Like Receptors / Q000276:immunology
D018925:Chemokines; D007370:Interferon Type I; D051193:Toll-Like Receptors