Blocking them all: beta-arrestins inhibit cellular signaling.
beta-arrestins are scaffold proteins that link G protein-coupled receptors to multiple "nonclassical" signaling pathways. In this issue of Molecular Cell, Mo et al. (2008) show that beta-arrestin1 also switches off signaling through the STAT1 transcription factor, thereby inhibiting interferon-induced antiviral responses.
Lohse
Martin J
MJ
Institute of Pharmacology and Toxicology, University of Würzburg, Versbacher Strasse 9, 97078 Würzburg, Germany. lohse@toxi.uni-wuerzburg.de
Klenk
Christoph
C
D000818:Animals; D019390:Arrestins / Q000235:genetics / Q000378:metabolism*; D007372:Interferons / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism; D050794:STAT1 Transcription Factor / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D014158:Transcription, Genetic; D000071557:beta-Arrestins
D019390:Arrestins; D043562:Receptors, G-Protein-Coupled; D050794:STAT1 Transcription Factor; D000071557:beta-Arrestins; D007372:Interferons