Hemophagocytic lymphohistiocytosis associated with Epstein Barr virus and Leishmania donovani coinfection in a child from Cyprus.
We present a case of a 9-month-old girl from Cyprus with hemophagocytic lymphohistiocytosis associated with Epstein Barr virus and Leishmania donovani coinfection. Treatment with liposomal amphotericin B resulted in a dramatic resolution of clinical and laboratory abnormalities. To our knowledge, this is the first reported case of a coinfection-associated hemophagocytic lymphohistiocytosis and the first clinical report of visceral leishmaniasis infection in Europe by L. donovani.
Koliou
Maria G
MG
Department of Pediatrics, Infectious Diseases and Immunology Unit, Archbishop Makarios Hospital, Nicosia, Cyprus. mkoliou@spidernet.com.cy
Soteriades
Elpidoforos S
ES
Ephros
Moshe
M
Mazeris
Apostolos
A
Antoniou
Maria
M
Elia
Avraam
A
Novelli
Vas
V
D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D003535:Cyprus; D020031:Epstein-Barr Virus Infections / Q000150:complications; D005260:Female; D004854:Herpesvirus 4, Human; D006801:Humans; D007223:Infant; D007893:Leishmania donovani; D007898:Leishmaniasis, Visceral / Q000150:complications; D051359:Lymphohistiocytosis, Hemophagocytic / Q000469:parasitology* / Q000821:virology*
D000666:Amphotericin B