Verbal working memory dysfunction in schizophrenia: an FMRI investigation.
Impaired processing of working memory information is one of the cognitive deficits seen in patients with schizophrenia. This study aims at corroborating the differences in the brain activities involved in the process of working memory between patients with schizophrenia and the controls. Twelve patients with schizophrenia and 11 controls participated in the study. Functional magnetic resonance imaging (fMRI) was used to assess cortical activities during the performance of a two-back verbal working memory paradigm using the Korean alphabet as mnemonic content. Group analysis revealed that inferior fontal, middle frontal, and superior temporal region showed decreased cortical activities in the patient group compared to those of the controls. This study showed a decreased activation in inferior fontal (BA 47), middle frontal (BA 6), and superior temporal (BA 22/38) neural networks from the patient group and confirmed the earlier findings on the impaired working memory of schizophrenic patients in the fMRI investigation.
Pae
Chi-Un
CU
Department of Psychiatry, Kangnam St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.
Juh
Rahyeong
R
Yoo
Seung-Schik
SS
Choi
Byung-Gil
BG
Lim
Hyun-Kook
HK
Lee
Chul
C
Paik
In-Ho
IH
Jeun
Sin Su
SS
Lee
Chang-Uk
CU
D000293:Adolescent; D000328:Adult; D001921:Brain / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology; D001931:Brain Mapping; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000209:etiology / Q000503:physiopathology* / Q000523:psychology; D008570:Memory, Short-Term / Q000502:physiology*; D008875:Middle Aged; D009048:Motor Skills / Q000502:physiology; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D012559:Schizophrenia / Q000150:complications; D014706:Verbal Learning / Q000502:physiology*; D055815:Young Adult
D010100:Oxygen