title: Non-septicemic melioidosis presenting as cardiac tamponade.
abstract: Melioidosis is endemic in Taiwan. It is caused by infection with Burkholderia pseudomallei. A prolonged course of oral eradication therapy to avoid relapse after an intensive intravenous therapy is recommended to treat melioidosis. Melioidosis with cardiac involvement is rare and is often combined with septicemia, for which the mortality rate is 20-60%. The initial clinical presentations of melioidosis mimic Mycobacterium tuberculosis infection, which is the most common etiology of bacterial pericarditis in Taiwan. We present a case of non-septicemic melioidosis that presented as non-suppurative cardiac tamponade and left subcarinal lymphadenopathy. Underlying diseases included hepatitis B-related liver cirrhosis and hepatocellular carcinoma. The patient was successfully treated with 2 weeks of intravenous ceftazidime and 12 weeks of oral doxycycline, trimethoprim-sulfamethoxazole, and amoxicillin/clavulanate. Melioidosis-related pericarditis should be considered in the differential diagnoses of bacterial pericarditis in Taiwan.
authors.affiliation: Division of Infectious Diseases and Division of Gastroenterology, Department of Internal Medicine, E-Da Hospital/I-Shou University, Kaohsiung County, Taiwan, Republic of China. ed102749@edah.org.tw
authors.forename: Hsing-Chun
authors.initials: HC
authors.lastname: Chung
authors.forename: Ching-Tai
authors.initials: CT
authors.lastname: Lee
authors.forename: Chung-Hsu
authors.initials: CH
authors.lastname: Lai
authors.forename: Chun-Kai
authors.initials: CK
authors.lastname: Huang
authors.forename: Jiun-Nong
authors.initials: JN
authors.lastname: Lin
authors.forename: Shiou-Haur
authors.initials: SH
authors.lastname: Liang
authors.forename: Hsi-Hsun
authors.initials: HH
authors.lastname: Lin
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000821:virology; D002305:Cardiac Tamponade / Q000209:etiology*; D003937:Diagnosis, Differential; D006509:Hepatitis B / Q000150:complications; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000821:virology; D008113:Liver Neoplasms / Q000150:complications / Q000821:virology; D008206:Lymphatic Diseases / Q000150:complications; D008297:Male; D008554:Melioidosis / Q000150:complications* / Q000188:drug therapy; D010493:Pericarditis / Q000209:etiology / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents