title: A dog with osteosarcoma which metastasized to the eye months before metastasis to other organs.
abstract: A 9-year-old male Shih Tzu with osteosarcoma had a forelimb amputation and underwent chemotherapy. During chemotherapy, the right eye was enucleated due to refractory glaucoma, and was diagnosed as anterior uveal malignant melanoma. The dog lived for 4 months after the enucleation without treatment. After the dog died, the mass in the eye was re-evaluated immunohistochemically, and it was diagnosed as metastasis of appendicular osteosarcoma. Metastasis of appendicular osteosarcoma to the anterior chamber is quite rare, and the clinical course which showed clinically detectable metastases to the eye before systemic multi-organ metastases was quite unique.
authors.affiliation: Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
authors.forename: Hiroto
authors.initials: H
authors.lastname: Yoshikawa
authors.forename: Yuya
authors.initials: Y
authors.lastname: Nakamoto
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Ozawa
authors.forename: Ryan M
authors.initials: RM
authors.lastname: Dickinson
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D015353:Eye Enucleation / Q000662:veterinary; D005134:Eye Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000556:secondary* / Q000601:surgery / Q000662:veterinary*; D017809:Fatal Outcome; D008297:Male; D009362:Neoplasm Metastasis / Q000473:pathology*; D012516:Osteosarcoma / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery / Q000662:veterinary
chemical_list: D000970:Antineoplastic Agents