title: [6-mercaptopurine-related hand-foot syndrome in a four-year-old child].
abstract: BACKGROUND
  Hand-foot syndrome (HFS) is a dose-dependent cutaneous side effect of cytostatic chemotherapy. It has also been described under the names of acral erythema and palmoplantar erythrodysesthesia. We report a case of HFS during treatment of acute lymphoblastic leukemia with 6-mercaptopurine (6-MP) (Purinethol) in a four-year-old child.
  
  
  METHODS
  A four-year-old boy treated for acute lymphoblastic leukemia developed dry and painful palmar and plantar erythema with fissures. The rash began three weeks after up-titration of 6-MP. There was no past history of cutaneous disease and no other potential trigger factors. The rash ceased after 6-MP withdrawal.
  
  
  CONCLUSIONS
  To our knowledge, this is the first case of HFS due to 6-MP therapy in a child. 6-MP is a major reference drug for the management of acute lymphoblastic leukemia. Numerous cytostatic drugs have been involved in such eruptions.
authors.affiliation: Service de dermatologie, hôpital Archet-2, CHU de Nice, B.P. 3079, 06202 Nice cedex 3, France. damiengiacchero@gmail.com
authors.forename: D
authors.initials: D
authors.lastname: Giacchero
authors.forename: F
authors.initials: F
authors.lastname: Monpoux
authors.forename: C
authors.initials: C
authors.lastname: Chiavérini
authors.forename: J-P
authors.initials: JP
authors.lastname: Lacour
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D002675:Child, Preschool; D003875:Drug Eruptions / Q000209:etiology*; D004890:Erythema / Q000139:chemically induced*; D005533:Foot Dermatoses / Q000139:chemically induced*; D006229:Hand Dermatoses / Q000139:chemically induced*; D006801:Humans; D008297:Male; D015122:Mercaptopurine / Q000009:adverse effects*; D010292:Paresthesia / Q000139:chemically induced*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D000964:Antimetabolites, Antineoplastic; D015122:Mercaptopurine