title: Disseminated intravascular coagulation (DIC) diagnosed based on the Japanese Association for Acute Medicine criteria is a dependent continuum to overt DIC in patients with sepsis.
abstract: BACKGROUND
  Sepsis is the most common disease associated with disseminated intravascular coagulation (DIC). To test the hypothesis that DIC diagnosed by the Japanese Association for Acute Medicine (JAAM) DIC scoring system (JAAM DIC) constitutes a dependent continuum to overt DIC diagnosed by the International Society on Thrombosis and Haemostasis (ISTH) overt DIC scoring system (ISTH overt DIC) in patients with sepsis, we conducted a retrospective study.
  
  
  METHODS
  The databases from two prospective, multicenter clinical investigations were analyzed. The inclusion criteria comprised patients with sepsis-related DIC, who met the JAAM DIC criteria.
  
  
  RESULTS
  The present study enrolled 166 patients, of whom 67 met the ISTH overt DIC criteria. All patients with sepsis who developed to overt DIC during the study period could be identified by the JAAM DIC diagnostic criteria in the first study. While the overall 28-day mortality was 31.3%, mortality (40.3%, p=0.0040) and the incidence of multiple organ dysfunction syndrome (70.1%, p=0.008) of the patients with the ISTH overt DIC was approximately one and a half times that of the patients associated with only the JAAM DIC. A stepwise increase in the ISTH overt DIC scores and the incidence of the ISTH overt DIC were also observed in accordance with the increase in the JAAM DIC scores.
  
  
  CONCLUSIONS
  DIC diagnosed based on the JAAM DIC diagnostic criteria exists in a dependent continuum to the ISTH overt DIC in patients with sepsis, thus enabling them to receive early treatment.
authors.affiliation: Division of Acute and Critical Care Medicine, Department of Anesthesiology, Hokkaido University Graduate School of Medicine, N17 W5, Kita-ku, Sapporo 060-8638 Japan. gando@med.hokudai.ac.jp
authors.forename: Satoshi
authors.initials: S
authors.lastname: Gando
authors.forename: Daizoh
authors.initials: D
authors.lastname: Saitoh
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ogura
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Mayumi
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Koseki
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Ikeda
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Ishikura
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Iba
authors.forename: Masashi
authors.initials: M
authors.lastname: Ueyama
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Eguchi
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Otomo
authors.forename: Kohji
authors.initials: K
authors.lastname: Okamoto
authors.forename: Shigeki
authors.initials: S
authors.lastname: Kushimoto
authors.forename: Shigeatsu
authors.initials: S
authors.lastname: Endo
authors.forename: Shuji
authors.initials: S
authors.lastname: Shimazaki
mesh_terms: D000328:Adult; D000368:Aged; D004211:Disseminated Intravascular Coagulation / Q000150:complications / Q000175:diagnosis* / Q000401:mortality; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D018805:Sepsis / Q000209:etiology*