Characterization and activity of cephalosporin metal complexes.
Semi-synthetic cephalosporin antibiotics have structures similar to that of penicillins, and both groups of compounds are characterized by similar properties and determined by the same methods. Most antibiotics, including cephalosporins and their decomposition products, contain electron donor groups that can bind naturally occurring metal ions in vivo. Cephalosporin antibiotics exhibit a change in their toxicological properties and biological performance when they were tested as metal complexes. The proposed reason for such a behavior is the capability of chelate binding of the cephalosporins to the metals. In an attempt to understand the coordination mode of metals with cephalosporins, different spectroscopic techniques such as IR, UV-visible, NMR spectroscopy and voltammetric measurements were carried out to elucidate the structure of the metal-cephalosporin complexes. Synthesis, characterization and biological screening of the cephalosporins and of the cephalosporin-metal complexes are discussed in this review. However, little information is available on the influence of the metal ions on the pharmacokinetics of the cephalosporin derivatives.
Auda
S H
SH
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Mrestani
Y
Y
Fetouh
M I
MI
Neubert
R H H
RH
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001702:Biopharmaceutics; D002511:Cephalosporins / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D003300:Copper / Q000737:chemistry; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D007616:Kaolin; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008670:Metals / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D051381:Rats; D017208:Rats, Wistar; D012995:Solubility; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013818:Thermogravimetry; D015032:Zinc / Q000737:chemistry
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D002511:Cephalosporins; D008670:Metals; D007616:Kaolin; D003300:Copper; D015032:Zinc