Introduction to bacterial signal transduction networks.
Transcriptional analysis using a DNA microarray is an extremely efficient method for analyzing two-component signal transduction networks. Here we introduce three such networks in Escherichia coli that were clarified using a DNA microarray: a PhoQ/PhoP system that senses extracellular Mg2+ and controls the gene expression for adaptation to environmental Mg2+ deprivation (Mg2+ stimulon); an EvgS/EvgA signal transduction system that activates expression of multiple drug efflux pumps and acid resistance genes; and a signal transduction cascade between EvgS/EvgA and PhoQ/PhoP.
Eguchi
Yoko
Y
Department of Bioscience, Graduate School of Agriculture, Kinki University, 3327 204 Nakamachi, Nara 631-8505, Japan.
Utsumi
Ryutaro
R
D018407:Bacterial Physiological Phenomena; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics / Q000502:physiology; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism; D005798:Genes, Bacterial; D008274:Magnesium / Q000378:metabolism; D053858:Metabolic Networks and Pathways; D008954:Models, Biological; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; C489314:EvgA protein, E coli; C465223:EvgS protein, E coli; C465562:PhoP protein, E coli; C079792:PhoQ protein, Bacteria; D014157:Transcription Factors; D011494:Protein Kinases; D008274:Magnesium