title: Chiral phosphonate internucleotide linkage: a promising modification for chimeric oligonucleotides?
abstract: We have synthesized two different groups of oligonucleotides containing chiral isopolar nonisosteric phosphonate internucleotide linkages, and studied their properties in combination with natural phosphodiester ones. The improved synthetic procedures for the monomers preparation are also reported.
authors.affiliation: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo n. 2, 166 10 Prague, Czech Republic.
authors.forename: Radek
authors.initials: R
authors.lastname: Liboska
authors.forename: Magdalena
authors.initials: M
authors.lastname: Petrová
authors.forename: Radek
authors.initials: R
authors.lastname: Pohl
authors.forename: Milos
authors.initials: M
authors.lastname: Budesínsky
authors.forename: Vladimíra
authors.initials: V
authors.lastname: Hurychová
authors.forename: Ivan
authors.initials: I
authors.lastname: Rosenberg
mesh_terms: D004247:DNA / Q000737:chemistry; D004722:Endoribonucleases / Q000737:chemistry; D007536:Isomerism; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D063065:Organophosphonates / Q000737:chemistry*; D012313:RNA / Q000737:chemistry
chemical_list: D009838:Oligodeoxyribonucleotides; D063065:Organophosphonates; D012313:RNA; D004247:DNA; D004722:Endoribonucleases; C031956:2-5A-dependent ribonuclease