Preoperative assessment of the risk factors that help to predict the prognosis after living donor liver transplantation.
BACKGROUND
The purpose of this study was to analyze various risk factors and to assess the preoperative risk score, which can predict the prognosis after living donor liver transplantation (LDLT).


METHODS
From February 2002 to August 2007, 84 adult to adult living donor liver transplantation donors and recipients were analyzed. First, the donor, recipient, and intraoperative factors were examined by univariate and multivariate analyses. We then gave a score of one point for each significant marginal factor (total point scores were called "risk score") and each risk score was examined by univariate analyses.


RESULTS
Recipients with the donor age 50 years or older, Model for End-Stage Liver Disease (MELD) score (> or =21), and hepatitis C virus-positive status had a significantly poor survival. Recipients between the risk score of 0 vs. scores of 2 + 3 (p < 0.001, log-rank) and risk score of 1 vs. scores of 2 + 3 (p = 0.003, log-rank) had significantly different survival.


CONCLUSIONS
Preoperative assessment of the risk score might help to predict recipient outcomes after living donor liver transplantation.
Yoshida
Ryuichi
R
Department of Gastroenterological Transplant Surgery and Surgical Oncology, Okayama University Graduate School of Medicine and Dentistry, 2-5-1, Shikata-Cyo, Okayama City, 700-8558, Okayama, Japan.
Iwamoto
Takayuki
T
Yagi
Takahito
T
Sato
Daisuke
D
Umeda
Yuzo
Y
Mizuno
Kenji
K
Shinoura
Susumu
S
Matsukawa
Hiroyoshi
H
Matsuda
Hiroaki
H
Sadamori
Hiroshi
H
Tanaka
Noriaki
N
D000328:Adult; D015331:Cohort Studies; D005260:Female; D006498:Hepatectomy; D006801:Humans; D017093:Liver Failure / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011300:Preoperative Care; D018570:Risk Assessment; D012307:Risk Factors; D015996:Survival Rate; D020858:Tissue and Organ Harvesting; D016896:Treatment Outcome
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