From ribonucleoside 5'-aldehydes to ribonucleoside 5'-C-phosphonates as building blocks for oligonucleotide synthesis.
The synthetic approach towards selected monomers of ribonucleosidyl-5'-C-phosphonates I compatible with the phosphotriester condensation method is presented, together with the surprising and unexpected effect of TEA.3HF on the phosphonate moiety observed upon removal of the O-silyl protecting groups.
Petrová
Maqdalena
M
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám 2, 166 10 Prague 6, Czech Republic.
Králíková
Sárka
S
Budesínský
Milos
M
Rosenberg
Ivan
I
D000447:Aldehydes / Q000737:chemistry; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D063065:Organophosphonates / Q000737:chemistry*; D012265:Ribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry
D000447:Aldehydes; D009841:Oligonucleotides; D063065:Organophosphonates; D012265:Ribonucleotides