Gastrointestinal symptoms in a sample of children with pervasive developmental disorders.
Objective To evaluate gastrointestinal (GI) problems in a large, well-characterized sample of children with pervasive developmental disorders (PDDs). Methods One hundred seventy two children entering one of two trials conducted by the Research Units on Pediatric Psychopharmacology (RUPP) Autism Network were assessed comprehensively prior to starting treatment and classified with regard to GI symptoms. Results Thirty nine (22.7%) were positive for GI problems, primarily constipation and diarrhea. Those with GI problems were no different from subjects without GI problems in demographic characteristics, measures of adaptive functioning, or autism symptom severity. Compared to children without GI problems, those with GI problems showed greater symptom severity on measures of irritability, anxiety, and social withdrawal. Those with GI problems were also less likely to respond to treatment.
Nikolov
Roumen N
RN
Yale Child Study Center, Yale University, P.O. Box 207900, New Haven, CT, USA. roumen.nikolov@yale.edu
Bearss
Karen E
KE
Lettinga
Jelle
J
Erickson
Craig
C
Rodowski
Maria
M
Aman
Michael G
MG
McCracken
James T
JT
McDougle
Christopher J
CJ
Tierney
Elaine
E
Vitiello
Benedetto
B
Arnold
L Eugene
LE
Shah
Bhavik
B
Posey
David J
DJ
Ritz
Louise
L
Scahill
Lawrence
L
D000223:Adaptation, Psychological; D000293:Adolescent; D001007:Anxiety / Q000523:psychology*; D001321:Autistic Disorder / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology*; D002648:Child; D002675:Child, Preschool; D003248:Constipation / Q000503:physiopathology*; D003967:Diarrhea / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D012720:Severity of Illness Index; D012920:Social Behavior Disorders / Q000523:psychology*
J Am Acad Child Adolesc Psychiatry. 2006 Sep;45(9):1114-23
16926619
J Clin Psychiatry. 2005;66 Suppl 10:19-25
16401146
N Engl J Med. 2002 Aug 1;347(5):314-21
12151468
J Psychosom Res. 2008 Jun;64(6):605-12
18501261
Am J Ment Defic. 1985 Mar;89(5):492-502
3158201
Am J Ment Retard. 2006 May;111(3):199-215
16597187
Pediatrics. 2006 Jul;118(1):e139-50
16818529
J Autism Dev Disord. 2007 Nov;37(10):1949-59
17186368
Res Dev Disabil. 2002 Jan-Feb;23(1):45-60
12071395
Curr Gastroenterol Rep. 2002 Jun;4(3):251-8
12010627
J Dev Behav Pediatr. 2006 Apr;27(2 Suppl):S128-36
16685179
Pediatrics. 2003 Oct;112(4):939-42
14523189
Am J Gastroenterol. 2000 Sep;95(9):2285-95
11007230
Curr Opin Pediatr. 2002 Oct;14(5):583-7
12352252
J Autism Dev Disord. 2005 Dec;35(6):713-27
16267642
Biol Psychiatry. 2007 Feb 15;61(4):492-7
17207470
Panminerva Med. 1995 Sep;37(3):137-41
8869369
J Clin Psychiatry. 2005;66 Suppl 10:3-8
16401144
Biol Psychiatry. 2007 Feb 15;61(4):429-37
16996486
Autism. 2003 Jun;7(2):165-71
12846385
Pediatrics. 2001 Oct;108(4):E58
11581466
Neurotoxicology. 2006 Sep;27(5):671-84
16644012
Am J Gastroenterol. 2005 Apr;100(4):979-81
15784047
Curr Opin Pediatr. 2003 Jun;15(3):339-43
12806268
J Pediatr. 1999 Nov;135(5):559-63
10547242
BMJ. 2002 Aug 24;325(7361):419-21
12193358
BMJ. 2002 Feb 16;324(7334):393-6
11850369
J Abnorm Child Psychol. 2008 Jan;36(1):117-28
17674186
Arch Gen Psychiatry. 2005 Nov;62(11):1266-74
16275814
J Autism Dev Disord. 2000 Apr;30(2):99-111
10832774
J Autism Dev Disord. 1997 Oct;27(5):501-17
9403369
Acta Paediatr. 1996 Sep;85(9):1076-9
8888921
J Pediatr Gastroenterol Nutr. 2006 Oct;43(4):477-82
17033522
Nat Genet. 2007 Mar;39(3):319-28
17322880
Am J Psychiatry. 2005 Jul;162(7):1361-9
15994720
Ment Retard Dev Disabil Res Rev. 2004;10(4):292-302
15666339