A common human leucocyte antigen-DP genotype is associated with resistance to HIV-1 infection in Kenyan sex workers.
Human leucocyte antigen-DP presents peptides to CD4 T cells and plays an important role in parasitic infections and autoimmune diseases, yet its influence on HIV-1 susceptibility has not been well studied. Here, we report several human leucocyte antigen-DP genotypes associated with HIV-1 susceptibility in Kenyan sex workers. Among these, one common genotype stands out. DPA1*010301 (frequency = 60.4%) was associated with HIV-1 resistance (P = 0.033, odds ratio = 1.585, 95% confidence interval = 1.036-2.425) and slower seroconversion (P = 0.001, log rank = 0.595, 95% confidence interval = 0.433-0.817). The discovery of common human leucocyte antigen-DP genotypes contributing to HIV-1 immunity may help overcome difficulties encountered with highly polymorphic human leucocyte antigens.
Hardie
Rae-Anne
RA
Department of Medical Microbiology, University of Manitoba, Canada.
Knight
Erin
E
Bruneau
Brigitte
B
Semeniuk
Christina
C
Gill
Kulvinder
K
Nagelkerke
Nico
N
Kimani
Joshua
J
Wachihi
Charles
C
Ngugi
Elizabeth
E
Luo
Ma
M
Plummer
Francis A
FA
D003430:Cross-Sectional Studies; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology / Q000635:transmission; D006679:HIV Seropositivity / Q000235:genetics; D015497:HIV-1; D006682:HLA-DP Antigens / Q000235:genetics*; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D011477:Sex Work
D006682:HLA-DP Antigens
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