title: Comparison of native or reformulated chicory fructans, or non-purified chicory, on rat cecal fermentation and mineral metabolism.
abstract: Chicory inulin has been identified as an effective prebiotic to promote active fermentation and lactobacilli proliferation in the large intestine, and to enhance calcium (Ca) digestive absorption and deposition in bones. The aim of this study was to compare, in a growing rat model, the effects on digestive fermentations and mineral metabolism of diets containing 7.5% inulin, using either a purified native inulin ((NAT)Inulin) or a reformulated inulin ((REF)Inulin, based on a combination of short- and long chain fructans) or dehydrated chicory. All the inulin diets elicited a marked enlargement of the cecum and acidification of the cecal contents (P < 0.01) and these diets promoted succinic acid rich fermentation together with substantial amounts of short-chain fatty acids (SCFA), especially butyrate. After 1 month of adaptation, all the inulin diets strongly enhanced Ca absorption compared to controls (P < 0.01), but this effect was no more observed after 3 months of adaptation. Magnesium (Mg) absorption was stimulated by the inulin diets after 1 and 3 months experiment. Bone parameters were significantly affected by the chicory diet (enhanced distal bone mineral density and breaking load) whereas the purified inulin diets were less effective. In conclusion, with the present model, both (NAT)Inulin and (REF)Inulin exerted similar effects as to (1) cecal fermentation and profile of end-products of bacterial metabolism, (2) stimulation of Ca and Mg digestive absorption and (3) overall effects on bone parameters. The particular effects of the chicory crude fractions on digestive fermentation and bone parameters suggest possible synergisms between inulin-type fructans and other nutrients.
authors.affiliation: UMR1019, Unité Nutrition Humaine, INRA, Centre Clermont-Ferrand-Theix, 63122, St Genès Champanelle, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Demigné
authors.forename: Heidi
authors.initials: H
authors.lastname: Jacobs
authors.forename: Corinne
authors.initials: C
authors.lastname: Moundras
authors.forename: Marie-Jeanne
authors.initials: MJ
authors.lastname: Davicco
authors.forename: Marie-Noëlle
authors.initials: MN
authors.lastname: Horcajada
authors.forename: Annick
authors.initials: A
authors.lastname: Bernalier
authors.forename: Véronique
authors.initials: V
authors.lastname: Coxam
mesh_terms: D000222:Adaptation, Physiological; D000375:Aging / Q000378:metabolism / Q000502:physiology; D000818:Animals; D002118:Calcium / Q000378:metabolism / Q000493:pharmacokinetics*; D002432:Cecum / Q000378:metabolism* / Q000382:microbiology; D018651:Cichorium intybus / Q000737:chemistry; D004195:Disease Models, Animal; D005285:Fermentation; D005630:Fructans / Q000494:pharmacology; D007408:Intestinal Absorption / Q000187:drug effects / Q000502:physiology; D007444:Inulin / Q000494:pharmacology*; D008274:Magnesium / Q000378:metabolism / Q000493:pharmacokinetics*; D008297:Male; D008903:Minerals / Q000493:pharmacokinetics*; D019936:Probiotics; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005630:Fructans; D008903:Minerals; D007444:Inulin; D008274:Magnesium; D002118:Calcium
references.citation: Bone. 1993 Jul-Aug;14(4):595-608
references.pmid: 8274302
references.citation: Exp Physiol. 1991 Jul;76(4):615-8
references.pmid: 1910768
references.citation: Nutr Res Rev. 2004 Jun;17(1):89-98
references.pmid: 19079918
references.citation: Bone. 2008 Feb;42(2):246-9
references.pmid: 18055288
references.citation: Bone. 2006 Mar;38(3):394-9
references.pmid: 16249132
references.citation: Swiss Med Wkly. 2001 Mar 10;131(9-10):127-32
references.pmid: 11416968
references.citation: Br J Nutr. 2002 Oct;88(4):365-77
references.pmid: 12323086
references.citation: Appl Environ Microbiol. 2006 Aug;72(8):5204-10
references.pmid: 16885266
references.citation: Asia Pac J Clin Nutr. 2008;17 Suppl 1:135-7
references.pmid: 18296321
references.citation: Proc Nutr Soc. 2003 Feb;62(1):67-72
references.pmid: 12740060
references.citation: Life Sci. 1995;57(17):1579-87
references.pmid: 7564905
references.citation: J Appl Microbiol. 2007 Feb;102(2):452-60
references.pmid: 17241351
references.citation: Curr Rheumatol Rep. 2007 Apr;9(1):85-92
references.pmid: 17437673
references.citation: J Nutr. 2007 Nov;137(11 Suppl):2503S-2506S
references.pmid: 17951493
references.citation: Am J Physiol. 1993 May;264(5 Pt 1):G855-62
references.pmid: 8388642
references.citation: Br J Nutr. 2007 Feb;97(2):365-72
references.pmid: 17298707
references.citation: Br J Nutr. 2005 Apr;93 Suppl 1:S13-25
references.pmid: 15877886
references.citation: J Nutr. 2007 Nov;137(11 Suppl):2507S-2512S
references.pmid: 17951494
references.citation: J Nutr Sci Vitaminol (Tokyo). 2003 Dec;49(6):414-21
references.pmid: 14974732
references.citation: Exp Physiol. 1994 Mar;79(2):215-26
references.pmid: 8003305
references.citation: Br J Nutr. 2005 Aug;94(2):192-7
references.pmid: 16115352
references.citation: Scand J Gastroenterol. 1998 Oct;33(10):1062-8
references.pmid: 9829361
references.citation: J Nutr. 1991 Nov;121(11):1730-7
references.pmid: 1941180
references.citation: Am J Clin Nutr. 2007 Dec;86(6):1780-90
references.pmid: 18065599
references.citation: J Nutr. 2008 Jan;138(1):172S-177S
references.pmid: 18156420
references.citation: Exp Biol Med (Maywood). 2003 Jun;228(6):683-8
references.pmid: 12773699
references.citation: Pflugers Arch. 1979 Feb 14;379(1):43-7
references.pmid: 34824
references.citation: Br J Nutr. 2006 Sep;96(3):570-7
references.pmid: 16925864
references.citation: Physiol Rev. 2002 Jan;82(1):245-89
references.pmid: 11773614
references.citation: J Nutr. 2007 Oct;137(10):2208-12
references.pmid: 17884999
references.citation: J Nutr. 2007 Mar;137(3 Suppl 2):838S-46S
references.pmid: 17311984
references.citation: Bone. 2005 Nov;37(5):728-35
references.pmid: 16126464
references.citation: Eur J Clin Nutr. 1997 Jun;51(6):375-80
references.pmid: 9192195