Association of arsenic and kidney dysfunction in people with diabetes and validation of its effects in rats.
We studied villagers with and without diabetes from arsenic-endemic areas and a nearby control site in Xinjiang Autonomous Region, PR China. Water and urinary arsenic were assayed for exposure measurement. Urinary NAG (N-acetyl-beta-glucosaminidase), a kidney function test, blood glucose, triglyceride, cholesterol, high density lipid and low density lipid were measured. Villagers from endemic areas were found to have higher urinary arsenic concentrations. The NAG results also suggest that chronic arsenic exposure presents a significant adverse impact on the kidney function of villagers in the endemic areas. However, blood glucose levels of diabetes individuals were lower than those from the control site. These observations were validated in rats which were chronically exposed to arsenic in drinking water. The distinct relationship between chronic arsenic exposure and diabetes mellitus requires further investigation. A rodent model is a useful tool for study of this type.
Wang
Jian Ping
JP
The University of Queensland, National Research Centre for Environmental Toxicology, Faculty of Health Sciences, 39 Kessels Road, Coopers Plains, Brisbane, QLD 4108, Australia.
Wang
Sheng Ling
SL
Lin
Qin
Q
Zhang
Ling
L
Huang
Daphne
D
Ng
Jack C
JC
D000818:Animals; D001151:Arsenic / Q000032:analysis / Q000652:urine; D020261:Arsenic Poisoning / Q000150:complications*; D001786:Blood Glucose / Q000032:analysis; D002681:China / Q000453:epidemiology; D002784:Cholesterol / Q000097:blood; D048909:Diabetes Complications; D005260:Female; D005966:Glucuronidase / Q000652:urine; D006801:Humans; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000209:etiology*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D051381:Rats; D012424:Rural Population; D014280:Triglycerides / Q000097:blood; D014874:Water Pollutants, Chemical / Q000032:analysis
D001786:Blood Glucose; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; D014874:Water Pollutants, Chemical; D002784:Cholesterol; C033263:N-acetyl-beta-glucuronidase; D005966:Glucuronidase; D001151:Arsenic