title: 5-Fluorouracil: mechanisms of resistance and reversal strategies.
abstract: The purpose of this work is to review the published studies on the mechanisms of action and resistance of 5-fluorouracil. The review is divided into three main sections: mechanisms of anti-tumor action, studies of the resistance to the drug, and procedures for the identification of new genes involved in resistance with microarray techniques. The details of the induction and reversal of the drug resistance are also described.
authors.affiliation: Department of Orthopaedics, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, 310009, P.R. China. zhangning98@gmail.com
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Yin
authors.forename: Sheng-Jie
authors.initials: SJ
authors.lastname: Xu
authors.forename: Wei-Shan
authors.initials: WS
authors.lastname: Chen
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D005472:Fluorouracil / Q000494:pharmacology* / Q000627:therapeutic use; D020869:Gene Expression Profiling; D006801:Humans
chemical_list: D000970:Antineoplastic Agents; D005472:Fluorouracil
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