Regulation of neural migration by the CREB/CREM transcription factors and altered Dab1 levels in CREB/CREM mutants.
The family of CREB transcription factors is involved in a variety of biological processes including the development and plasticity of the nervous system. To gain further insight into the roles of CREB family members in the development of the embryonic brain, we examined the migratory phenotype of CREB1(Nescre)CREM(-/-) mutants. We found that the lack of CREB/CREM genes is accompanied by anatomical defects in specific layers of the olfactory bulb, hippocampus and cerebral cortex. These changes are associated with decreased Dab1 expression in CREB1(Nescre)CREM(-/-) mutants. Our results indicate that the lack of CREB/CREM genes, specifically in neural and glial progenitors, leads to migration abnormalities during brain development, suggesting that unidentified age-dependent factors modulate the role of CREB/CREM genes in neural development.
Díaz-Ruiz
Carmen
C
Institute for Research in Biomedicine-Barcelona (IRB), Department of Cell Biology and CIBERNED (ISCIII), University of Barcelona, Barcelona Science Park, Lab A1-S1, Josep Samitier 1-5, Barcelona 08028, Spain.
Parlato
Rosanna
R
Aguado
Fernando
F
Ureña
Jesús M
JM
Burgaya
Ferran
F
Martínez
Albert
A
Carmona
Maria A
MA
Kreiner
Grzegorz
G
Bleckmann
Susanne
S
Del Río
Jose A
JA
Schütz
Günther
G
Soriano
Eduardo
E
D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000166:cytology / Q000196:embryology* / Q000502:physiology; D002465:Cell Movement / Q000502:physiology*; D051786:Cyclic AMP Response Element Modulator / Q000235:genetics / Q000378:metabolism*; D017362:Cyclic AMP Response Element-Binding Protein / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000502:physiology*
D017362:Cyclic AMP Response Element-Binding Protein; C103773:Dab1 protein, mouse; D009419:Nerve Tissue Proteins; D051786:Cyclic AMP Response Element Modulator