Synthesis of nucleoside-based antiviral drugs in ionic liquids.
Nucleoside-based antiviral drugs have been synthesized using imidazolium-based ionic liquids as reaction medium. The ionic liquids were proved to be better solvents for all the nucleoside in terms of solubility and reaction medium as compared to conventional molecular solvents.
Kumar
Vineet
V
Laboratory of Synthetic Chemistry, SAIC-Frederick Inc., National Cancer Institute-Frederick, 1050 Boyles Street, Frederick, MD 21702, USA.
Malhotra
Sanjay V
SV
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001973:Bromodeoxyuridine / Q000031:analogs & derivatives / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D006678:HIV / Q000378:metabolism; D006801:Humans; D007093:Imidazoles / Q000737:chemistry; D052578:Ionic Liquids / Q000737:chemistry*; D008956:Models, Chemical; D009705:Nucleosides / Q000737:chemistry*; D018139:Simplexvirus / Q000378:metabolism; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D018119:Stavudine / Q000737:chemistry; D014271:Trifluridine / Q000737:chemistry
D000998:Antiviral Agents; D007093:Imidazoles; D052578:Ionic Liquids; D009705:Nucleosides; D012997:Solvents; C020235:brivudine; D018119:Stavudine; D001973:Bromodeoxyuridine; D014271:Trifluridine