Acute hepatitis A in a pregnant woman at delivery.
We report a case of acute hepatitis A in a 30-year-old pregnant woman with hepatitis onset occurring at time of delivery. Both neonate and her mother were isolated from other patients. The hepatitis A virus (HAV) genotype was Ia. Total anti-HAV antibodies and HAV RNA were not detected from the newborn in a serum collected the first day of life; neither clinical symptoms nor increased ALT levels were observed during the six first days of life. The mother quickly and fully recovered. Hepatitis A has been scarcely reported during pregnancy; four cases, to our knowledge, have been previously described close to delivery. HAV vertical transmission seems to be very rare. No severe outcome has been described in mothers and newborns. Nevertheless, HAV infection might represent a concern in pregnant women in industrialized countries in view of its mortality rate among susceptible adults and its potential involvement in nosocomial outbreaks.
Motte
Anne
A
Laboratoire de Virologie, Fédération Hospitalière de Bactériologie-Virologie Clinique, Centre Hospitalo-Universitaire Timone, 264 rue Saint-Pierre, 13385 Marseille cedex 05, France.
Blanc
Julie
J
Minodier
Philippe
P
Colson
Philippe
P
D000208:Acute Disease; D036861:Delivery, Obstetric; D005260:Female; D005838:Genotype; D006506:Hepatitis A / Q000175:diagnosis / Q000635:transmission / Q000821:virology; D035922:Hepatitis A Antibodies / Q000097:blood; D017957:Hepatitis A Virus, Human / Q000145:classification* / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology*; D012367:RNA, Viral / Q000097:blood; D020133:Reverse Transcriptase Polymerase Chain Reaction
D035922:Hepatitis A Antibodies; D012367:RNA, Viral