Mixed Candida albicans strain populations in colonized and infected mucosal tissues.
Multilocus sequence typing of six Candida albicans colonies from primary isolation plates revealed instances of colony-to-colony microvariation and carriage of two strain types in single oropharyngeal and vaginal samples. Higher rates of colony variation in commensal samples suggest selection of types from mixed populations either in the shift to pathogenicity or the response to antifungal treatment.
Jacobsen
Mette D
MD
Aberdeen Fungal Group, Institute of Medical Sciences, Aberdeen, UK.
Duncan
Amanda D
AD
Bain
Judith
J
Johnson
Elizabeth M
EM
Naglik
Julian R
JR
Shaw
Duncan J
DJ
Gow
Neil A R
NA
Odds
Frank C
FC
D000328:Adult; D002176:Candida albicans / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D002180:Candidiasis, Oral / Q000453:epidemiology* / Q000382:microbiology; D002181:Candidiasis, Vulvovaginal / Q000453:epidemiology* / Q000382:microbiology; D002353:Carrier State / Q000382:microbiology; D004271:DNA, Fungal / Q000032:analysis / Q000235:genetics; D005260:Female; D006801:Humans; D009092:Mucous Membrane / Q000382:microbiology*; D016533:Mycological Typing Techniques; D009960:Oropharynx / Q000382:microbiology; D017422:Sequence Analysis, DNA; D014621:Vagina / Q000382:microbiology; D055815:Young Adult
D004271:DNA, Fungal
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