In vitro activity of compounds isolated from Piper crassinervium against Trypanosoma cruzi.
This study describes the antichagasic potential of five compounds isolated from leaves of Piper crassinervium (Piperaceae). Two prenylated benzoic acid derivatives, one prenylated hydroquinone and two flavanones, were evaluated. The in vitro trypanocidal activity was determined against epimastigote forms of Trypanosoma cruzi (Y strain), the etiologic agent of Chagas disease. The most active compound was the prenylated hydroquinone [1,4-dihydroxy-2-(3(0),7(0)-dimethyl-1(0)-oxo-2(0)-E,6(0)-octadienyl)benzene] with an IC(50) value of 6.10 microg mL(-1), which was in the same order of activity if compared with the positive control benznidazole (IC(50) = 1.60 microg mL(-1)). This is the first report of trypanocidal activity for prenylated hydroquinone and benzoic acid derivatives.
Lopes
Adriana Aparecida
AA
Instituto de Quimica, Universidade Estadual Paulista, Araraquara, SP, Brazil.
López
Silvia Noelí
SN
Regasini
Luis Octávio
LO
Junior
João Marcos Batista
JM
Ambrósio
Daniela Luz
DL
Kato
Massuo Jorge
MJ
da Silva Bolzani
Vanderlan
V
Cicarelli
Regina Maria Barretto
RM
Furlan
Maysa
M
D000818:Animals; D031701:Piper / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D014344:Trypanocidal Agents / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects*
D010936:Plant Extracts; D014344:Trypanocidal Agents