Comparison of native or reformulated chicory fructans, or non-purified chicory, on rat cecal fermentation and mineral metabolism.
Chicory inulin has been identified as an effective prebiotic to promote active fermentation and lactobacilli proliferation in the large intestine, and to enhance calcium (Ca) digestive absorption and deposition in bones. The aim of this study was to compare, in a growing rat model, the effects on digestive fermentations and mineral metabolism of diets containing 7.5% inulin, using either a purified native inulin ((NAT)Inulin) or a reformulated inulin ((REF)Inulin, based on a combination of short- and long chain fructans) or dehydrated chicory. All the inulin diets elicited a marked enlargement of the cecum and acidification of the cecal contents (P < 0.01) and these diets promoted succinic acid rich fermentation together with substantial amounts of short-chain fatty acids (SCFA), especially butyrate. After 1 month of adaptation, all the inulin diets strongly enhanced Ca absorption compared to controls (P < 0.01), but this effect was no more observed after 3 months of adaptation. Magnesium (Mg) absorption was stimulated by the inulin diets after 1 and 3 months experiment. Bone parameters were significantly affected by the chicory diet (enhanced distal bone mineral density and breaking load) whereas the purified inulin diets were less effective. In conclusion, with the present model, both (NAT)Inulin and (REF)Inulin exerted similar effects as to (1) cecal fermentation and profile of end-products of bacterial metabolism, (2) stimulation of Ca and Mg digestive absorption and (3) overall effects on bone parameters. The particular effects of the chicory crude fractions on digestive fermentation and bone parameters suggest possible synergisms between inulin-type fructans and other nutrients.
Demigné
Christian
C
UMR1019, Unité Nutrition Humaine, INRA, Centre Clermont-Ferrand-Theix, 63122, St Genès Champanelle, France.
Jacobs
Heidi
H
Moundras
Corinne
C
Davicco
Marie-Jeanne
MJ
Horcajada
Marie-Noëlle
MN
Bernalier
Annick
A
Coxam
Véronique
V
D000222:Adaptation, Physiological; D000375:Aging / Q000378:metabolism / Q000502:physiology; D000818:Animals; D002118:Calcium / Q000378:metabolism / Q000493:pharmacokinetics*; D002432:Cecum / Q000378:metabolism* / Q000382:microbiology; D018651:Cichorium intybus / Q000737:chemistry; D004195:Disease Models, Animal; D005285:Fermentation; D005630:Fructans / Q000494:pharmacology; D007408:Intestinal Absorption / Q000187:drug effects / Q000502:physiology; D007444:Inulin / Q000494:pharmacology*; D008274:Magnesium / Q000378:metabolism / Q000493:pharmacokinetics*; D008297:Male; D008903:Minerals / Q000493:pharmacokinetics*; D019936:Probiotics; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D005630:Fructans; D008903:Minerals; D007444:Inulin; D008274:Magnesium; D002118:Calcium
Bone. 1993 Jul-Aug;14(4):595-608
8274302
Exp Physiol. 1991 Jul;76(4):615-8
1910768
Nutr Res Rev. 2004 Jun;17(1):89-98
19079918
Bone. 2008 Feb;42(2):246-9
18055288
Bone. 2006 Mar;38(3):394-9
16249132
Swiss Med Wkly. 2001 Mar 10;131(9-10):127-32
11416968
Br J Nutr. 2002 Oct;88(4):365-77
12323086
Appl Environ Microbiol. 2006 Aug;72(8):5204-10
16885266
Asia Pac J Clin Nutr. 2008;17 Suppl 1:135-7
18296321
Proc Nutr Soc. 2003 Feb;62(1):67-72
12740060
Life Sci. 1995;57(17):1579-87
7564905
J Appl Microbiol. 2007 Feb;102(2):452-60
17241351
Curr Rheumatol Rep. 2007 Apr;9(1):85-92
17437673
J Nutr. 2007 Nov;137(11 Suppl):2503S-2506S
17951493
Am J Physiol. 1993 May;264(5 Pt 1):G855-62
8388642
Br J Nutr. 2007 Feb;97(2):365-72
17298707
Br J Nutr. 2005 Apr;93 Suppl 1:S13-25
15877886
J Nutr. 2007 Nov;137(11 Suppl):2507S-2512S
17951494
J Nutr Sci Vitaminol (Tokyo). 2003 Dec;49(6):414-21
14974732
Exp Physiol. 1994 Mar;79(2):215-26
8003305
Br J Nutr. 2005 Aug;94(2):192-7
16115352
Scand J Gastroenterol. 1998 Oct;33(10):1062-8
9829361
J Nutr. 1991 Nov;121(11):1730-7
1941180
Am J Clin Nutr. 2007 Dec;86(6):1780-90
18065599
J Nutr. 2008 Jan;138(1):172S-177S
18156420
Exp Biol Med (Maywood). 2003 Jun;228(6):683-8
12773699
Pflugers Arch. 1979 Feb 14;379(1):43-7
34824
Br J Nutr. 2006 Sep;96(3):570-7
16925864
Physiol Rev. 2002 Jan;82(1):245-89
11773614
J Nutr. 2007 Oct;137(10):2208-12
17884999
J Nutr. 2007 Mar;137(3 Suppl 2):838S-46S
17311984
Bone. 2005 Nov;37(5):728-35
16126464
Eur J Clin Nutr. 1997 Jun;51(6):375-80
9192195