title: A novel synthesis of 1-nosyl 3,3-dichloro-beta-lactams and derivatives.
abstract: We report herein an efficient and simple route to synthesize 1-nosyl 3,3-dichloro-beta-lactams using a Staudinger reaction between N-nosyl imines and dichloroketene. The resulting dichloroazetidines were opened to afford highly functionalized building blocks.
authors.affiliation: Laboratoire de Chimie Moléculaire et Thio-organique, ENSICAEN, Université de Caen Basse-Normandie, CNRS, 6, Boulevard du Maréchal Juin, 14050, Caen, France.
authors.forename: Francisco
authors.initials: F
authors.lastname: Tato
authors.forename: Vincent
authors.initials: V
authors.lastname: Reboul
authors.forename: Patrick
authors.initials: P
authors.lastname: Metzner
mesh_terms: D001384:Azetidines; D005030:Ethylenes / Q000737:chemistry; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry; D007097:Imines / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D047090:beta-Lactams / Q000138:chemical synthesis*
chemical_list: D001384:Azetidines; D005030:Ethylenes; D006843:Hydrocarbons, Chlorinated; D007097:Imines; D007659:Ketones; D047090:beta-Lactams; C008223:ketene