title: Ketoprofen spray-dried microspheres based on Eudragit RS and RL: study of the manufacturing parameters.
abstract: The preparation of ketoprofen spray-dried microspheres can be affected by the long drug recrystallization time. Polymer type and drug-polymer ratio as well as manufacturing parameters affect the preparation. The purpose of this work was to evaluate the possibility to obtain ketoprofen spray-dried microspheres using the Eudragit RS and RL; the influence of the spray-drying parameters on morphology, dimension, and physical stability of microspheres was studied. Ketoprofen microspheres based on Eudragit blend can be prepared by spray-drying and the nebulization parameters do not influence significantly particle properties; nevertheless, they can be affected by drying and storage methods. No effect of the container material is found.
authors.affiliation: Department of Drug Sciences, University of Sassari, Sassari, Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Rassu
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Gavini
authors.forename: Gianpiera
authors.initials: G
authors.lastname: Spada
authors.forename: Paolo
authors.initials: P
authors.lastname: Giunchedi
authors.forename: Salvatore
authors.initials: S
authors.lastname: Marceddu
mesh_terms: D000180:Acrylic Resins / Q000032:analysis / Q000138:chemical synthesis*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004355:Drug Stability; D007660:Ketoprofen / Q000032:analysis / Q000138:chemical synthesis*; D008863:Microspheres; D010316:Particle Size
chemical_list: D000180:Acrylic Resins; C050528:Eudragit RS; D007660:Ketoprofen