title: Spatial updating and the maintenance of visual constancy.
abstract: Spatial updating is the means by which we keep track of the locations of objects in space even as we move. Four decades of research have shown that humans and non-human primates can take the amplitude and direction of intervening movements into account, including saccades (both head-fixed and head-free), pursuit, whole-body rotations and translations. At the neuronal level, spatial updating is thought to be maintained by receptive field locations that shift with changes in gaze, and evidence for such shifts has been shown in several cortical areas. These regions receive information about the intervening movement from several sources including motor efference copies when a voluntary movement is made and vestibular/somatosensory signals when the body is in motion. Many of these updating signals arise from brainstem regions that monitor our ongoing movements and subsequently transmit this information to the cortex via pathways that likely include the thalamus. Several issues of debate include (1) the relative contribution of extra-retinal sensory and efference copy signals to spatial updating, (2) the source of an updating signal for real life, three-dimensional motion that cannot arise from brain areas encoding only two-dimensional commands, and (3) the reference frames used by the brain to integrate updating signals from various sources. This review highlights the relevant spatial updating studies and provides a summary of the field today. We find that spatial constancy is maintained by a highly evolved neural mechanism that keeps track of our movements, transmits this information to relevant brain regions, and then uses this information to change the way in which single neurons respond. In this way, we are able to keep track of relevant objects in the outside world and interact with them in meaningful ways.
authors.affiliation: Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, USA. eliana@cabernet.wustl.edu
authors.forename: E M
authors.initials: EM
authors.lastname: Klier
authors.forename: D E
authors.initials: DE
authors.lastname: Angelaki
mesh_terms: D000818:Animals; D005133:Eye Movements / Q000502:physiology*; D019416:Head Movements / Q000502:physiology*; D006801:Humans; D009949:Orientation; D010775:Photic Stimulation / Q000379:methods; D013028:Space Perception / Q000502:physiology*; D014785:Vision, Ocular / Q000502:physiology*; D014794:Visual Fields / Q000502:physiology
references.citation: Nat Neurosci. 2005 Jul;8(7):941-9
references.pmid: 15951810
references.citation: J Neurophysiol. 1998 Nov;80(5):2785-9
references.pmid: 9819282
references.citation: J Neurophysiol. 1997 Sep;78(3):1373-83
references.pmid: 9310428
references.citation: Science. 1991 May 31;252(5010):1313-5
references.pmid: 1925545
references.citation: J Neurophysiol. 2007 Feb;97(2):1738-55
references.pmid: 17093130
references.citation: J Neurophysiol. 1996 Dec;76(6):3617-32
references.pmid: 8985862
references.citation: Science. 1995 Jul 7;269(5220):95-8
references.pmid: 7604286
references.citation: J Neurophysiol. 2004 Jun;91(6):2628-48
references.pmid: 14762161
references.citation: J Comput Neurosci. 2006 Aug;21(1):51-70
references.pmid: 16633937
references.citation: Science. 1980 Jun 6;208(4448):1163-5
references.pmid: 6769161
references.citation: J Neurosci. 2004 Oct 20;24(42):9291-302
references.pmid: 15496665
references.citation: J Neurophysiol. 2006 May;95(5):2751-67
references.pmid: 16291805
references.citation: Exp Brain Res. 1998 Sep;122(1):93-100
references.pmid: 9772116
references.citation: J Neurophysiol. 1997 Jun;77(6):3180-92
references.pmid: 9212267
references.citation: J Neurophysiol. 2001 Oct;86(4):2112-7
references.pmid: 11600667
references.citation: J Neurophysiol. 2004 Mar;91(3):1381-402
references.pmid: 14573558
references.citation: Exp Brain Res. 2001 Mar;137(1):45-57
references.pmid: 11310171
references.citation: Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):4026-31
references.pmid: 11904446
references.citation: J Neurophysiol. 2008 Apr;99(4):1799-809
references.pmid: 18256164
references.citation: J Neurosci. 2007 Dec 12;27(50):13590-602
references.pmid: 18077671
references.citation: J Comput Neurosci. 2007 Apr;22(2):191-209
references.pmid: 17120151
references.citation: J Neurophysiol. 1995 May;73(5):1988-2003
references.pmid: 7623096
references.citation: Neuron. 2005 Oct 6;48(1):149-58
references.pmid: 16202715
references.citation: J Neurosci. 2003 Jul 16;23(15):6209-14
references.pmid: 12867504
references.citation: J Neurophysiol. 1987 Aug;58(2):300-18
references.pmid: 3655869
references.citation: Behav Brain Res. 2005 Sep 8;163(2):194-203
references.pmid: 15970337
references.citation: J Comp Physiol Psychol. 1950 Dec;43(6):482-9
references.pmid: 14794830
references.citation: Acta Otolaryngol. 1995 Jan;115(1):3-8
references.pmid: 7762380
references.citation: J Physiol. 2007 Jul 15;582(Pt 2):647-64
references.pmid: 17510192
references.citation: J Neurophysiol. 2004 Oct;92(4):2380-93
references.pmid: 15190097
references.citation: Vision Res. 1976 Jan;16(1):99-106
references.pmid: 1258395
references.citation: Exp Brain Res. 1993;96(2):335-46
references.pmid: 8270026
references.citation: Neuron. 2003 Jul 17;39(2):361-73
references.pmid: 12873391
references.citation: Exp Brain Res. 2000 Sep;134(1):66-73
references.pmid: 11026727
references.citation: J Neurosci. 2003 Sep 3;23(22):8135-42
references.pmid: 12954876
references.citation: Neuroreport. 2002 Feb 11;13(2):253-5
references.pmid: 11893920
references.citation: Nat Neurosci. 2007 May;10(5):640-6
references.pmid: 17396123
references.citation: J Neurophysiol. 2004 Apr;91(4):1608-19
references.pmid: 14668290
references.citation: J Vis. 2003 Dec 04;3(11):761-70
references.pmid: 14765959
references.citation: Exp Brain Res. 1983;49(3):381-92
references.pmid: 6641836
references.citation: J Neurophysiol. 2007 Feb;97(2):1209-20
references.pmid: 17135474
references.citation: J Mot Behav. 1995 Jun;27(2):114-122
references.pmid: 12736121
references.citation: Adv Otorhinolaryngol. 1988;41:71-5
references.pmid: 3265009
references.citation: Neurosci Lett. 2002 Jan 18;318(1):34-8
references.pmid: 11786219
references.citation: J Neurophysiol. 1990 Aug;64(2):489-508
references.pmid: 2213128
references.citation: J Neurophysiol. 2003 May;89(5):2564-76
references.pmid: 12740406
references.citation: Exp Brain Res. 1992;89(2):425-34
references.pmid: 1623984
references.citation: Vision Res. 1995 Aug;35(15):2191-9
references.pmid: 7667931
references.citation: Trends Cogn Sci. 2006 Dec;10(12):551-7
references.pmid: 17071127
references.citation: Exp Brain Res. 2001 Nov;141(1):33-51
references.pmid: 11685409
references.citation: Eur J Neurosci. 2001 Mar;13(6):1177-89
references.pmid: 11285015
references.citation: Nat Neurosci. 2001 Jun;4(6):627-32
references.pmid: 11369944
references.citation: J Neurophysiol. 2003 Mar;89(3):1519-27
references.pmid: 12612015
references.citation: J Neurophysiol. 2007 Jul;98(1):105-21
references.pmid: 17493922
references.citation: Brain Cogn. 1995 Oct;29(1):1-22
references.pmid: 8845120
references.citation: J Neurosci. 2002 Jan 1;22(1):RC196
references.pmid: 11756525
references.citation: Cereb Cortex. 1995 Sep-Oct;5(5):470-81
references.pmid: 8547793
references.citation: Invest Ophthalmol Vis Sci. 1994 Feb;35(2):509-14
references.pmid: 8113001
references.citation: J Neurophysiol. 2007 Jul;98(1):537-44
references.pmid: 17442766
references.citation: Proc Biol Sci. 2002 Apr 7;269(1492):735-9
references.pmid: 11934366
references.citation: J Neurophysiol. 1983 Jan;49(1):45-63
references.pmid: 6827303
references.citation: Nature. 2006 Nov 16;444(7117):374-7
references.pmid: 17093408
references.citation: Brain Res. 1979 Nov 9;177(1):3-17
references.pmid: 115546
references.citation: Philos Trans R Soc Lond B Biol Sci. 1997 Oct 29;352(1360):1449-59
references.pmid: 9368933
references.citation: J Neurophysiol. 2006 Sep;96(3):1676-82
references.pmid: 16760354
references.citation: Exp Brain Res. 1994;102(1):1-9
references.pmid: 7895785
references.citation: J Neurophysiol. 2001 Nov;86(5):2344-52
references.pmid: 11698524
references.citation: J Neurophysiol. 2003 May;89(5):2839-53
references.pmid: 12740415
references.citation: J Neurophysiol. 2005 Nov;94(5):3228-48
references.pmid: 15888534
references.citation: J Neurophysiol. 2006 Apr;95(4):2692-7
references.pmid: 16371458
references.citation: Philos Trans R Soc Lond B Biol Sci. 2007 Mar 29;362(1479):375-82
references.pmid: 17255021
references.citation: Eur J Neurosci. 2006 Oct;24(8):2375-88
references.pmid: 17074057
references.citation: J Neurophysiol. 1987 Oct;58(4):832-49
references.pmid: 3681398
references.citation: J Neurophysiol. 2005 Dec;94(6):4300-13
references.pmid: 16107519
references.citation: Psychol Res. 1995;58(3):169-76
references.pmid: 8570785
references.citation: Exp Brain Res. 1999 Mar;125(1):50-60
references.pmid: 10100976
references.citation: J Neurophysiol. 1990 Aug;64(2):575-81
references.pmid: 2213134
references.citation: Science. 2002 May 24;296(5572):1480-2
references.pmid: 12029137
references.citation: Annu Rev Neurosci. 1997;20:303-30
references.pmid: 9056716
references.citation: J Neurophysiol. 2005 Jul;94(1):722-33
references.pmid: 15788513
references.citation: Exp Brain Res. 2006 Mar;169(4):532-48
references.pmid: 16374631
references.citation: Brain. 1992 Oct;115 ( Pt 5):1387-402
references.pmid: 1422794
references.citation: J Neurophysiol. 2005 Jul;94(1):468-78
references.pmid: 15716372
references.citation: Nature. 1998 Aug 27;394(6696):887-91
references.pmid: 9732870
references.citation: Science. 1999 Jul 9;285(5425):257-60
references.pmid: 10398603
references.citation: J Neurophysiol. 2005 Mar;93(3):1510-22
references.pmid: 15483070
references.citation: J Neurophysiol. 2005 Aug;94(2):1432-42
references.pmid: 15857971
references.citation: J Neurophysiol. 2003 Sep;90(3):2029-52
references.pmid: 12724361
references.citation: J Neurol Neurosurg Psychiatry. 2000 Feb;68(2):234-7
references.pmid: 10644797
references.citation: Exp Brain Res. 2005 Aug;164(4):431-41
references.pmid: 15895218
references.citation: J Comput Neurosci. 2008 Apr;24(2):157-78
references.pmid: 17636448
references.citation: Ann Neurol. 1995 Nov;38(5):739-48
references.pmid: 7486865
references.citation: Exp Brain Res. 1999 Sep;128(1-2):170-80
references.pmid: 10473755
references.citation: Science. 1992 Jan 3;255(5040):90-2
references.pmid: 1553535
references.citation: Perception. 1991;20(3):393-402
references.pmid: 1762882
references.citation: Science. 1983 Sep 16;221(4616):1193-5
references.pmid: 6612334
references.citation: J Neurophysiol. 1986 Jul;56(1):196-207
references.pmid: 3746396
references.citation: Nature. 1995 May 18;375(6528):232-5
references.pmid: 7746323
references.citation: Exp Brain Res. 1997 Jun;115(2):267-82
references.pmid: 9224855
references.citation: Rev Oculomot Res. 1989;3:361-90
references.pmid: 2486330
references.citation: J Neurosci. 1995 Oct;15(10):6461-74
references.pmid: 7472409
references.citation: J Neurophysiol. 2004 Mar;91(3):1403-23
references.pmid: 14573557
references.citation: Neuroreport. 1998 May 11;9(7):1469-73
references.pmid: 9631450
references.citation: Brain Res. 1996 Jul 15;727(1-2):221-4
references.pmid: 8842402
references.citation: J Neurophysiol. 2007 Apr;97(4):2958-64
references.pmid: 17287442
references.citation: Nat Neurosci. 2003 Aug;6(8):877-81
references.pmid: 12872128
references.citation: Neural Comput. 2007 Sep;19(9):2353-86
references.pmid: 17650063
references.citation: Exp Brain Res. 2005 Mar;161(4):432-40
references.pmid: 15578170
references.citation: Nature. 2002 Jan 24;415(6870):429-33
references.pmid: 11807554
references.citation: Exp Brain Res. 1991;84(1):47-56
references.pmid: 1855564
references.citation: Vision Res. 1976 Jan;16(1):107-14
references.pmid: 1258384
references.citation: J Neurophysiol. 2004 May;91(5):2205-14
references.pmid: 14668294
references.citation: J Neurophysiol. 2005 Nov;94(5):3249-58
references.pmid: 15888533