title: Acyclovir-resistant chronic verrucous vaccine strain varicella in a patient with neuroblastoma.
abstract: A 21-month-old girl with neuroblastoma developed chronic verrucous Oka strain varicella-zoster infection during chemotherapy. Virus isolated from the patient demonstrated high-level acyclovir resistance, and its thymidine kinase had no in vitro enzymatic activity. After foscarnet therapy, she underwent stem cell transplantation without varicella reactivation. This is only the second reported case of resistant varicella zoster virus caused by Oka strain virus.
authors.affiliation: Division of Pediatric Hematology/Oncology, University of Alabama at Birmingham, Birmingham, AL, USA. Coleman.Bryan@med.navy.mil
authors.forename: Coleman J
authors.initials: CJ
authors.lastname: Bryan
authors.forename: Mark N
authors.initials: MN
authors.lastname: Prichard
authors.forename: Shannon
authors.initials: S
authors.lastname: Daily
authors.forename: Geraldine
authors.initials: G
authors.lastname: Jefferson
authors.forename: Caroll
authors.initials: C
authors.lastname: Hartline
authors.forename: Kevin A
authors.initials: KA
authors.lastname: Cassady
authors.forename: Lee
authors.initials: L
authors.lastname: Hilliard
authors.forename: Masako
authors.initials: M
authors.lastname: Shimamura
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D002644:Chickenpox / Q000188:drug therapy / Q000209:etiology*; D019433:Chickenpox Vaccine / Q000009:adverse effects*; D002908:Chronic Disease; D024882:Drug Resistance, Viral; D005260:Female; D014645:Herpesvirus 3, Human / Q000187:drug effects*; D006801:Humans; D016867:Immunocompromised Host; D007223:Infant; D009447:Neuroblastoma / Q000150:complications* / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D019433:Chickenpox Vaccine; D000212:Acyclovir