title: Antidepressant behavioral effects of duloxetine and amitriptyline in the rat forced swimming test.
abstract: OBJECTIVE
  To compare the effects of the antidepressant drugs duloxetine and amitriptyline on depressive behaviors in rats.
  
  
  METHODS
  Fifteen male Wistar rats were given systemic injections of duloxetine, amitriptyline or saline prior to a Forced Swimming Test (FST). Immobility and number of stops were measured. Data were analyzed by one-way ANOVA and Kruskall-Wallis.
  
  
  RESULTS
  Rats given injections of duloxetine displayed fewer stops than the amitriptyline and control group (p< 0.05). The control group and Amitriptyline showed no difference (p=0.8).
  
  
  CONCLUSIONS
  Duloxetine reduced depressive behaviors in the Forced Swimming Test been more effective than amitriptyline.
authors.affiliation: IC, Cardiology University Foundation, Porto Alegre, Brazil. hsmenezes@computech.com.br
authors.forename: Honório Sampaio
authors.initials: HS
authors.lastname: Menezes
authors.forename: Bárbara Beatriz Moreira
authors.initials: BB
authors.lastname: Bueno
authors.forename: Leandro
authors.initials: L
authors.lastname: Ciulla
authors.forename: Alexandre
authors.initials: A
authors.lastname: Schuh
authors.forename: Fernanda de Freitas
authors.initials: Fde F
authors.lastname: Luz
authors.forename: Rafael José Vargas
authors.initials: RJ
authors.lastname: Alves
authors.forename: Milena Pacheco
authors.initials: MP
authors.lastname: Abegg
authors.forename: Sílvia Letícia Merceo Bacchi
authors.initials: SL
authors.lastname: Cirino
mesh_terms: D000639:Amitriptyline / Q000627:therapeutic use*; D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003863:Depression / Q000188:drug therapy* / Q000523:psychology; D004195:Disease Models, Animal; D000068736:Duloxetine Hydrochloride; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013550:Swimming / Q000523:psychology*; D013876:Thiophenes / Q000627:therapeutic use*
chemical_list: D000928:Antidepressive Agents; D013876:Thiophenes; D000639:Amitriptyline; D000068736:Duloxetine Hydrochloride