title: Salvileucalin B, a novel diterpenoid with an unprecedented rearranged neoclerodane skeleton from Salvia leucantha Cav.
abstract: Salvileucalin B (2), having an unprecedented rearranged neoclerodane skeleton, was isolated from the aerial parts of Salvia leucantha Cav. (Labiatae) along with salvileucalin A (1). The absolute structures were elucidated by spectroscopic analysis, X-ray crystallographic analysis, and vibrational circular dichroism. Compound 2 represents a novel neoclerodane, characterized by a tricyclo[3.2.1.0 (2,7)]octane substructure incorporating the exocyclic C-20 methylene of 1. This molecule exerted cytotoxic activity against A549 and HT-29 cells with IC50 values of 5.23 and 1.88 microg/mL, respectively.
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy & Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Aoyagi
authors.forename: Akira
authors.initials: A
authors.lastname: Yamazaki
authors.forename: Chihiro
authors.initials: C
authors.lastname: Nakatsugawa
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Fukaya
authors.forename: Koichi
authors.initials: K
authors.lastname: Takeya
authors.forename: Susumu
authors.initials: S
authors.lastname: Kawauchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Izumi
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D045785:Diterpenes, Clerodane; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D027544:Salvia / Q000737:chemistry*
chemical_list: D004224:Diterpenes; D045785:Diterpenes, Clerodane; C468586:neoclerodane; C533291:salvileucalin B