Increased thyroid volume, prevalence of thyroid antibodies and impaired fasting glucose in young adults from organochlorine cocktail polluted area: outcome of transgenerational transmission?
In 137 females (F) and 94 males (M) aged 21-35 years from organochlorines (OCs) polluted area (POLL) increased thyroid volume (ThV), prevalence of antibodies to thyroperoxidase (TPOab), thyrotropin receptor (TRab) and of impaired fasting glucose (IFG) was found compared to 116 F and 107 M from background pollution area (BCGR). In F and M from POLL also strikingly increased level of PCBs, DDE and HCB was found. Such findings were compared to the generation of their parents aged 41-55 years consisting of 320F/213M from POLL and 406F/231M from BCGR. However, in spite of strikingly lower level of those OCs in young adults from POLL, they showed about the same prevalence of adverse health signs as the old generation. From such reason 44 young F and 40 young M with lowest PCBs level from POLL were selected to obtain nearly the same PCB level as found in all young F and M from BCGR. In such PCB adjusted groups the prevalence of TPOab, TRab, IFG and increased ThV was still significantly higher than that in all young subjects from BCGR. At the same time, also the level of DDE and HCB in such PCBs adjusted groups was considerably lower. It was concluded that such adverse effects in young adults from POLL possibly did not result from their actual OCs levels, but very likely from their exposure to high OCs levels of their mothers during their prenatal and perinatal life. Thus, the data may be compatible with present views on transgenerational transmission of endocrine disruptors action.
Langer
Pavel
P
Laboratory of Diabetes and Nutrition, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, 833 06 Bratislava, Slovakia. pavel.langer@savba.sk
Kocan
Anton
A
Tajtáková
Mária
M
Koska
Juraj
J
Rádiková
Zofia
Z
Ksinantová
Lucia
L
Imrich
Richard
R
Hucková
Miloslava
M
Drobná
Beáta
B
Gasperíková
Daniela
D
Seböková
Elena
E
Klimes
Iwar
I
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D016009:Chi-Square Distribution; D003633:Dichlorodiphenyl Dichloroethylene / Q000097:blood; D004785:Environmental Pollutants / Q000097:blood / Q000633:toxicity*; D005215:Fasting; D005260:Female; D005659:Fungicides, Industrial / Q000097:blood; D005947:Glucose / Q000032:analysis*; D006581:Hexachlorobenzene / Q000097:blood; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000097:blood / Q000633:toxicity*; D007306:Insecticides / Q000097:blood; D007453:Iodide Peroxidase / Q000276:immunology; D008297:Male; D018811:Maternal Exposure; D008875:Middle Aged; D009929:Organ Size; D011078:Polychlorinated Biphenyls / Q000097:blood; D011989:Receptors, Thyrotropin / Q000276:immunology; D013961:Thyroid Gland / Q000187:drug effects*; D055815:Young Adult
D001323:Autoantibodies; D004785:Environmental Pollutants; D005659:Fungicides, Industrial; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides; D011989:Receptors, Thyrotropin; D003633:Dichlorodiphenyl Dichloroethylene; D006581:Hexachlorobenzene; D011078:Polychlorinated Biphenyls; D007453:Iodide Peroxidase; D005947:Glucose