Synthesis of carbocyclic 2-substituted adenine nucleoside and related analogs.
2-Iodonoraristeromycin, 2-iodoaristeromycin and related analogs were synthesized to investigate their inhibitory activities against human and Plasmodium falciparum S-adenosyl-L-homocysteine hydrolases.
Zulfiqar
Fazila
F
Department of Biomolecular Science, Faculty of Engineering, Gifu University, Gifu, Japan.
Kojima
Hiroharu
H
Nakanishi
Masayuki
M
Ando
Takayuki
T
Kitade
Yukio
Y
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D015394:Molecular Structure; D009699:N-Glycosyl Hydrolases / Q000037:antagonists & inhibitors*; D010963:Plasmodium falciparum / Q000201:enzymology*
C030034:aristeromycin; D009699:N-Glycosyl Hydrolases; D000241:Adenosine