title: Ethnicity and left ventricular diastolic function in hypertension an ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) substudy.
abstract: OBJECTIVE
  We investigated whether diastolic function differs between hypertensive patients of African-Caribbean or white European origin and established whether differences could be explained by confounding variables.
  
  
  BACKGROUND
  African Caribbeans are known to have a higher prevalence of heart failure than white Europeans but it is unclear whether this is a result of known risk factors. Tissue Doppler technology now allows accurate quantification of diastolic function, which is recognized as an important factor in the development of heart failure.
  
  
  METHODS
  Participants from a single center participating in the ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial), composed of patients with hypertension but no evidence of heart failure, were studied. Left ventricular structure and function were measured in 509 patients using conventional and tissue Doppler echocardiography. Diastolic function was assessed using the tissue Doppler early diastolic velocity E' (averaged from 3 left ventricular segments) and the ratio of this and the transmitral early filling velocity E (E/E').
  
  
  RESULTS
  In African-Caribbean patients, mean E' was significantly lower (7.7 cm/s vs. 8.6 cm/s, p = 0.003) and mean E/E' was significantly higher (8.85 vs. 7.93, p = 0.003). After adjustment for confounding variables-age, gender, systolic blood pressure, pulse pressure, cholesterol, smoking, ejection fraction, left ventricular mass index, and diabetes mellitus-the effect of African-Caribbean ethnicity on diastolic function remained highly significant (E': 7.52 vs. 8.51; p < 0.001; E/E': 8.89 vs. 7.93; p = 0.003; African Caribbeans vs. white Europeans for both comparisons).
  
  
  CONCLUSIONS
  Diastolic function is significantly worse in hypertensive patients of African-Caribbean origin than in white Europeans. This difference in diastolic performance is not due to known confounding variables.
authors.affiliation: International Centre for Circulatory Health, St Mary's Hospital and Imperial College London, London, United Kingdom. andrewsharp@doctors.org.uk
authors.forename: Andrew
authors.initials: A
authors.lastname: Sharp
authors.forename: Robyn
authors.initials: R
authors.lastname: Tapp
authors.forename: Darrel P
authors.initials: DP
authors.lastname: Francis
authors.forename: Simon A
authors.initials: SA
authors.lastname: McG Thom
authors.forename: Alun D
authors.initials: AD
authors.lastname: Hughes
authors.forename: Alice V
authors.initials: AV
authors.lastname: Stanton
authors.forename: Andrew
authors.initials: A
authors.lastname: Zambanini
authors.forename: Nish
authors.initials: N
authors.lastname: Chaturvedi
authors.forename: Sheila
authors.initials: S
authors.lastname: Byrd
authors.forename: Neil R
authors.initials: NR
authors.lastname: Poulter
authors.forename: Peter S
authors.initials: PS
authors.lastname: Sever
authors.forename: Jamil
authors.initials: J
authors.lastname: Mayet
mesh_terms: D000328:Adult; D000368:Aged; D044383:Black People; D003971:Diastole; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D006973:Hypertension / Q000208:ethnology* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016277:Ventricular Function, Left; D014900:West Indies / Q000208:ethnology; D044465:White People