title: From ribonucleoside 5'-aldehydes to ribonucleoside 5'-C-phosphonates as building blocks for oligonucleotide synthesis.
abstract: The synthetic approach towards selected monomers of ribonucleosidyl-5'-C-phosphonates I compatible with the phosphotriester condensation method is presented, together with the surprising and unexpected effect of TEA.3HF on the phosphonate moiety observed upon removal of the O-silyl protecting groups.
authors.affiliation: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám 2, 166 10 Prague 6, Czech Republic.
authors.forename: Maqdalena
authors.initials: M
authors.lastname: Petrová
authors.forename: Sárka
authors.initials: S
authors.lastname: Králíková
authors.forename: Milos
authors.initials: M
authors.lastname: Budesínský
authors.forename: Ivan
authors.initials: I
authors.lastname: Rosenberg
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D063065:Organophosphonates / Q000737:chemistry*; D012265:Ribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000447:Aldehydes; D009841:Oligonucleotides; D063065:Organophosphonates; D012265:Ribonucleotides