Synthesis and antiviral evaluation of 4-fluoropyrazole-3-carboxamide nucleoside derivatives.
A series of novel 4-fluoro-1H-pyrazole-3-carboxamide nucleoside analogues were synthesized and evaluated as potential inhibitors of RNA virus replication, including hepatitis C virus (HCV).
Leroy
Frederic
F
Idenix Pharmaceuticals, Medicinal Chemistry Laboratory, Cap Gamma, 1682 Rue de la Valsière, 34189 Montpellier Cedex 4, France. leroy.frederic@idenix.com
Chaves
Dominique
D
Dukhan
David
D
Storer
Richard
R
Sommadossi
Jean-Pierre
JP
Loi
Anna Giulia
AG
Cadeddu
Alessandra
A
Fanti
Maura
M
Boscu
Nadia
N
Bassetti
Fabiola
F
Liuzzi
Michel
M
Gosselin
Gilles
G
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D016174:Hepacivirus / Q000187:drug effects; D012254:Ribavirin / Q000031:analogs & derivatives*
D000998:Antiviral Agents; D012254:Ribavirin