title: Role of STAT3 in inflammatory bowel disease.
abstract: Signal transducers and activators of transcription 3 (STAT3) play an important role in various autoimmune disorders including inflammatory bowel disease (IBD). Recent studies have revealed that STAT3 activation plays distinctly different roles between innate immune responses and acquired immune responses in colitis. STAT3-mediated activation of acquired immune responses plays a pathogenic role in colitis by enhancing the survival of pathogenic T cells. In contrast, STAT3-mediated activation of innate responses contributes to the suppression of colitis. This review will summarize the current understanding of the roles of STAT3 in IBD and the potential of targeting STAT3 for the treatment of IBD, emphasizing recent observations.
authors.affiliation: Experimental Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States. sugiken@jg8.so-net.ne.jp
authors.forename: Ken
authors.initials: K
authors.lastname: Sugimoto
mesh_terms: D006801:Humans; D007110:Immunity, Active / Q000276:immunology / Q000502:physiology; D007113:Immunity, Innate / Q000276:immunology / Q000502:physiology; D015212:Inflammatory Bowel Diseases / Q000276:immunology / Q000503:physiopathology*; D050796:STAT3 Transcription Factor / Q000502:physiology*
chemical_list: D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human
references.citation: Science. 2001 May 11;292(5519):1115-8
references.pmid: 11352068
references.citation: Gastroenterology. 2001 Mar;120(4):925-37
references.pmid: 11231946
references.citation: J Clin Invest. 2008 Feb;118(2):534-44
references.pmid: 18172556
references.citation: Gastroenterology. 1996 Dec;111(6):1706-13
references.pmid: 8942753
references.citation: Gastroenterology. 2002 Jun;122(7):1829-41
references.pmid: 12055591
references.citation: J Clin Invest. 2004 May;113(9):1296-306
references.pmid: 15124021
references.citation: Gastroenterology. 2004 Apr;126(4):989-96; discussion 947
references.pmid: 15057738
references.citation: Annu Rev Immunol. 2002;20:495-549
references.pmid: 11861611
references.citation: Gastroenterology. 2002 Dec;123(6):1877-88
references.pmid: 12454845
references.citation: Int Immunopharmacol. 2004 May;4(5):679-91
references.pmid: 15120652
references.citation: Immunity. 2002 Feb;16(2):219-30
references.pmid: 11869683
references.citation: Am J Physiol. 1999 Sep;277(3):G495-9
references.pmid: 10484372
references.citation: Hepatology. 2004 May;39(5):1332-42
references.pmid: 15122762
references.citation: Nat Med. 2002 Oct;8(10):1089-97
references.pmid: 12219085
references.citation: Curr Opin Immunol. 1999 Dec;11(6):648-56
references.pmid: 10631550
references.citation: Inflamm Bowel Dis. 2007 Aug;13(8):1016-23
references.pmid: 17476678
references.citation: J Immunol. 2000 May 1;164(9):4878-82
references.pmid: 10779797
references.citation: Gastroenterology. 2002 Jun;122(7):2011-25
references.pmid: 12055606
references.citation: J Biol Chem. 2003 May 9;278(19):16777-81
references.pmid: 12615922
references.citation: Front Biosci. 2001 Oct 01;6:D1321-57
references.pmid: 11578958
references.citation: Gastroenterology. 2006 Nov;131(5):1501-17
references.pmid: 17101324
references.citation: Am J Gastroenterol. 2005 Jan;100(1):73-4
references.pmid: 15654783
references.citation: Gastroenterology. 1999 Jul;117(1):58-64
references.pmid: 10381910
references.citation: Mol Cell Biol. 1993 Jan;13(1):276-88
references.pmid: 7678052
references.citation: Lab Invest. 1998 Dec;78(12):1503-12
references.pmid: 9881950
references.citation: Inflamm Bowel Dis. 2005 Feb;11(2):91-8
references.pmid: 15677901
references.citation: EMBO J. 1999 Sep 1;18(17):4657-68
references.pmid: 10469645
references.citation: J Immunol. 1998 Nov 1;161(9):4652-60
references.pmid: 9794394
references.citation: Immunity. 1999 Jan;10(1):39-49
references.pmid: 10023769
references.citation: Cytokine. 2004 Apr 21;26(2):45-56
references.pmid: 15050604
references.citation: Nat Rev Mol Cell Biol. 2002 Sep;3(9):651-62
references.pmid: 12209125
references.citation: Nat Rev Immunol. 2004 May;4(5):371-9
references.pmid: 15122202
references.citation: Am J Physiol Gastrointest Liver Physiol. 2006 Apr;290(4):G827-38
references.pmid: 16537974
references.citation: Gastroenterology. 2004 May;126(6):1620-33
references.pmid: 15168372
references.citation: Inflamm Bowel Dis. 2003 Jul;9(4):246-59
references.pmid: 12902848
references.citation: Oncogene. 2000 May 15;19(21):2607-11
references.pmid: 10851059
references.citation: J Exp Med. 1996 Jul 1;184(1):241-51
references.pmid: 8691138
references.citation: J Cell Sci. 2004 Mar 15;117(Pt 8):1281-3
references.pmid: 15020666
references.citation: Hum Gene Ther. 2000 Aug 10;11(12):1731-41
references.pmid: 10954907
references.citation: Nat Med. 2002 Jun;8(6):567-73
references.pmid: 12042806
references.citation: Annu Rev Immunol. 2001;19:683-765
references.pmid: 11244051
references.citation: Immunity. 2004 Aug;21(2):241-54
references.pmid: 15308104
references.citation: Nat Med. 2008 Mar;14(3):247-9
references.pmid: 18323844
references.citation: J Exp Med. 2006 Oct 2;203(10):2271-9
references.pmid: 16982811
references.citation: Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1879-84
references.pmid: 12571365
references.citation: Postgrad Med J. 2000 Aug;76(898):473-8
references.pmid: 10908374
references.citation: N Engl J Med. 2002 Aug 8;347(6):417-29
references.pmid: 12167685
references.citation: Nature. 2007 Feb 8;445(7128):648-51
references.pmid: 17187052
references.citation: Immunity. 1995 Aug;3(2):171-4
references.pmid: 7648390
references.citation: J Exp Med. 2001 Feb 19;193(4):471-81
references.pmid: 11181699
references.citation: Immunity. 2001 Jul;15(1):149-58
references.pmid: 11485746
references.citation: J Immunol. 2002 Jul 1;169(1):460-8
references.pmid: 12077277
references.citation: Annu Rev Immunol. 2000;18:143-64
references.pmid: 10837055
references.citation: Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3801-4
references.pmid: 9108058
references.citation: Immunity. 2004 Jun;20(6):681-93
references.pmid: 15189734
references.citation: J Biol Chem. 2004 Mar 12;279(11):10304-15
references.pmid: 14701802
references.citation: N Engl J Med. 2000 Jun 1;342(22):1633-7
references.pmid: 10833209
references.citation: Nat Med. 2000 May;6(5):583-8
references.pmid: 10802717
references.citation: Am J Gastroenterol. 2005 Jan;100(1):64-72
references.pmid: 15654782