title: Genetic variation of Omi/HtrA2 and Parkinson's disease.
abstract: Variants in the Omi/HtrA2 gene have been nominated as a cause of Parkinson's disease. This sequencing study of Omi/HtrA2 in 95 probands with apparent autosomal dominant inheritance of Parkinson's disease did not identify any pathogenic mutations. In addition, there was no association between common variations in the Omi/HtrA2 gene and susceptibility to Parkinson's disease in any of our four patient-control series (n=2373). Taken together our results do not support a role for Omi/HtrA2 variants in the pathogenesis of Parkinson's disease.
authors.affiliation: Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, United States. ross.owen@mayo.edu
authors.forename: Owen A
authors.initials: OA
authors.lastname: Ross
authors.forename: Alexandra I
authors.initials: AI
authors.lastname: Soto
authors.forename: Carles
authors.initials: C
authors.lastname: Vilariño-Güell
authors.forename: Michael G
authors.initials: MG
authors.lastname: Heckman
authors.forename: Nancy N
authors.initials: NN
authors.lastname: Diehl
authors.forename: Mary M
authors.initials: MM
authors.lastname: Hulihan
authors.forename: Jan O
authors.initials: JO
authors.lastname: Aasly
authors.forename: Sigrid
authors.initials: S
authors.lastname: Sando
authors.forename: J Mark
authors.initials: JM
authors.lastname: Gibson
authors.forename: Timothy
authors.initials: T
authors.lastname: Lynch
authors.forename: Anna
authors.initials: A
authors.lastname: Krygowska-Wajs
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Opala
authors.forename: Maria
authors.initials: M
authors.lastname: Barcikowska
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Czyzewski
authors.forename: Ryan J
authors.initials: RJ
authors.lastname: Uitti
authors.forename: Zbigniew K
authors.initials: ZK
authors.lastname: Wszolek
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Farrer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D014644:Genetic Variation / Q000235:genetics*; D000074923:High-Temperature Requirement A Serine Peptidase 2; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D024101:Mitochondrial Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D010300:Parkinson Disease / Q000235:genetics*; D012697:Serine Endopeptidases / Q000235:genetics*
chemical_list: D024101:Mitochondrial Proteins; D012697:Serine Endopeptidases; C000615914:HTRA2 protein, human; D000074923:High-Temperature Requirement A Serine Peptidase 2
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