[Levels of environmental endocrine disruptors in umbilical cord blood and maternal blood of low-birth-weight infants].
OBJECTIVE
To monitor the biological levels of environmental endocrine disruptors (EDs, phthalates and surfactants) in the umbilical cord blood and maternal blood of low-birth-weight infants.


METHODS
All 30 umbilical cord blood samples and 21 maternal blood samples were collected from low-birth-weight infants. The concentration of four kinds of phthalates (di-2-ethylhexyl phthalate, DEHP; mono-2-ethylhexyl phthalate, MEHP; di-ethyl phthalate, DEP; di-n-butyl phthalate, DBP) and two kinds of surfactants (4-nonylphenol, 4-NP; octylphenol, OP) in these blood samples were measured by using reversed-phase high performance liquid chromatography.


RESULTS
The mean birth weight and birth length of low-birth-weight infants were (2158.48 +/- 125.06) g and (45.36 +/- 2.52) cm, respectively. The concentrations of DEP, MEHP, DBP, DEHP, 4-NP and OP were 18.90, 11.87, 7.67, 8.84, 1.51 and 2. 86 mg/L in maternal blood, and the detective rates were 86.7%, 63.3%, 60.0%, 63.3%, 56.7% and 66.7%, respectively. In umbilical cord blood, the concentrations of those EDs were 11.92, 9.94, 5.71, 5.20, 1.12 and 1.19 mg/L; the detective rates were 86.7%, 63.3%, 60.0%, 63.3%, 56.7% and 66.7%. No matter in maternal blood or in umbilical cord blood, the contents and detective rates of phthalates were higher than the surfactants. The concentration of MEHP was higher than its primer, DEHP. The contents of the target EDs in umbilical cord blood were less than those in the matched maternal blood. The percentages were 47.82% -84.05%.


CONCLUSIONS
People could be exposed to EDs from embryo period. And this should be paid attention by the related departments.
Lin
Ling
L
Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China.
Zheng
Li-Xing
LX
Gu
Yue-Ping
YP
Wang
Jie-Yun
JY
Zhang
Yun-Hui
YH
Song
Wei-Min
WM
D004051:Diethylhexyl Phthalate / Q000097:blood*; D052244:Endocrine Disruptors / Q000097:blood*; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007223:Infant; D007230:Infant, Low Birth Weight / Q000097:blood*; D007231:Infant, Newborn; D009035:Mothers; D013501:Surface-Active Agents
D052244:Endocrine Disruptors; D013501:Surface-Active Agents; D004051:Diethylhexyl Phthalate