title: Association of Mycoplasma arthritidis mitogen with lethal toxicity but not with arthritis in mice.
abstract: Mycoplasma arthritidis induces an acute to chronic arthritis in rodents. Arthritis induced in mice histologically resembles human rheumatoid arthritis and can be associated with lethal toxicity following systemic injection. The M. arthritidis mitogen (MAM) superantigen has long been implicated as having a role in pathogenesis, but its significance with respect to toxicity and arthritogenicity in mycoplasma-induced disease is unclear. To study the pathogenic significance of MAM, M. arthritidis mutants that overproduced or failed to produce MAM were developed. MAM overproduction and knockout mutants were more and less mitogenic, respectively, than the wild-type strain. The degree of mitogenic activity correlated with lethal toxicity in DBA/2J mice. In contrast, histopathological studies detected no correlation between MAM production and the severity of arthritis induced in DBA/2J and CBA/J mice.
authors.affiliation: Department of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294-0024, USA.
authors.forename: Wenyi
authors.initials: W
authors.lastname: Luo
authors.forename: Huilan
authors.initials: H
authors.lastname: Yu
authors.forename: Zuhua
authors.initials: Z
authors.lastname: Cao
authors.forename: Trenton R
authors.initials: TR
authors.lastname: Schoeb
authors.forename: Michele
authors.initials: M
authors.lastname: Marron
authors.forename: Kevin
authors.initials: K
authors.lastname: Dybvig
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000235:genetics / Q000633:toxicity*; D001169:Arthritis, Experimental / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D001170:Arthritis, Infectious / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D005260:Female; D051379:Mice; D009175:Mycoplasma Infections / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D045645:Mycoplasma arthritidis / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D018089:Superantigens / Q000235:genetics / Q000633:toxicity*
chemical_list: D000942:Antigens, Bacterial; C052996:Mycoplasma arthritidis mitogen; D018089:Superantigens
references.citation: J Exp Anim Sci. 1993 Apr;35(4):177-85
references.pmid: 8329470
references.citation: Mol Immunol. 2007 Feb;44(5):763-73
references.pmid: 16753217
references.citation: J Bacteriol. 2004 Sep;186(17):5715-20
references.pmid: 15317776
references.citation: J Bacteriol. 1998 Nov;180(22):5928-31
references.pmid: 9811651
references.citation: Infect Immun. 2004 Dec;72(12):7322-5
references.pmid: 15557660
references.citation: Autoimmunity. 1992;14(1):23-32
references.pmid: 1299344
references.citation: Plasmid. 2002 Mar;47(2):129-37
references.pmid: 11982334
references.citation: Infect Immun. 1996 Feb;64(2):441-7
references.pmid: 8550189
references.citation: J Immunol. 1990 Jan 15;144(2):420-4
references.pmid: 2295798
references.citation: J Rheumatol. 2000 Feb;27(2):358-64
references.pmid: 10685797
references.citation: Clin Exp Immunol. 2003 Sep;133(3):299-306
references.pmid: 12930353
references.citation: Arthritis Rheum. 1979 Dec;22(12):1375-81
references.pmid: 518719
references.citation: Infect Immun. 1997 Oct;65(10):4190-8
references.pmid: 9317026
references.citation: Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10921-5
references.pmid: 1660155
references.citation: Infect Immun. 2001 Jun;69(6):3837-44
references.pmid: 11349049
references.citation: FEMS Immunol Med Microbiol. 2007 Mar;49(2):266-71
references.pmid: 17328760
references.citation: J Exp Med. 1996 Mar 1;183(3):1105-10
references.pmid: 8642252
references.citation: J Bacteriol. 1989 Sep;171(9):5165-8
references.pmid: 2768200
references.citation: J Rheumatol. 1985 Apr;12(2):217-22
references.pmid: 3875716
references.citation: Arthritis Rheum. 1980 Jul;23(7):825-36
references.pmid: 6996688
references.citation: Infect Immun. 1971 Jan;3(1):24-35
references.pmid: 16557942
references.citation: J Infect Dis. 2002 Aug 1;186(3):432-5
references.pmid: 12134243
references.citation: J Rheumatol. 1988;15(5):735-41
references.pmid: 3262748
references.citation: Ann Allergy. 1988 May;60(5):394-8
references.pmid: 3369750
references.citation: Infect Immun. 1973 Feb;7(2):218-25
references.pmid: 4572611
references.citation: J Bacteriol. 1996 Oct;178(20):6078-81
references.pmid: 8830712
references.citation: Cell Microbiol. 2005 Jun;7(6):789-97
references.pmid: 15888082
references.citation: Infect Immun. 2000 Mar;68(3):1142-9
references.pmid: 10678918
references.citation: Immunol Today. 1991 Aug;12(8):271-6
references.pmid: 1910449
references.citation: J Immunol. 1989 Jun 15;142(12):4131-7
references.pmid: 2786024
references.citation: Infect Immun. 1983 Sep;41(3):1010-5
references.pmid: 6885154
references.citation: Methods Mol Biol. 2004;271:25-35
references.pmid: 15146110
references.citation: FEMS Microbiol Lett. 2005 Dec 15;253(2):315-21
references.pmid: 16260096
references.citation: J Bacteriol. 2002 Feb;184(4):947-51
references.pmid: 11807054
references.citation: Infect Immun. 1971 Oct;4(4):344-55
references.pmid: 5154887
references.citation: Infect Immun. 2003 Feb;71(2):671-5
references.pmid: 12540544
references.citation: Infect Immun. 2000 Feb;68(2):437-42
references.pmid: 10639401
references.citation: Curr Top Microbiol Immunol. 1991;174:107-19
references.pmid: 1802617
references.citation: J Immunol. 1981 Nov;127(5):1931-6
references.pmid: 7299118
references.citation: Arthritis Rheum. 1993 Jul;36(7):994-1002
references.pmid: 8318046
references.citation: Infect Immun. 1995 Oct;63(10):4016-23
references.pmid: 7558313
references.citation: Infect Immun. 2005 Jan;73(1):245-9
references.pmid: 15618160
references.citation: Infect Immun. 2008 Sep;76(9):4000-8
references.pmid: 18573899
references.citation: Mol Microbiol. 2008 Jul;69(1):67-76
references.pmid: 18452587
references.citation: Infect Immun. 2003 Oct;71(10):5733-8
references.pmid: 14500494
references.citation: J Invest Dermatol. 1985 Oct;85(4):357-61
references.pmid: 4045222
references.citation: Infect Immun. 1994 Jan;62(1):135-44
references.pmid: 8262619
references.citation: J Biol Chem. 2006 Aug 4;281(31):21594-21606
references.pmid: 16717097
references.citation: Infect Immun. 1993 Jun;61(6):2670-80
references.pmid: 8500906
references.citation: J Exp Med. 1998 Feb 2;187(3):319-27
references.pmid: 9449712
references.citation: Arthritis Rheum. 1992 Apr;35(4):434-42
references.pmid: 1533125
references.citation: Infect Immun. 1982 May;36(2):662-6
references.pmid: 6979514
references.citation: Clin Diagn Lab Immunol. 1997 May;4(3):321-7
references.pmid: 9144371