title: Investigation of the carbopol gel of solid lipid nanoparticles for the transdermal iontophoretic delivery of triamcinolone acetonide acetate.
abstract: The purpose of this study was to investigate solid lipid nanoparticles (SLN) hydrogel for transdermal iontophoretic drug delivery. Triamcinolone acetonide acetate (TAA), a glucocorticoids compound, was employed as the model drug. SLN containing the drug triamcinolone acetonide acetate (TAA-SLN) and their carbopol gel with stable physicochemical properties were prepared. The use of TAA-SLN carbopol gel as a vehicle for the transdermal iontophoretic delivery of TAA was evaluated in vitro using horizontal diffusion cells fitted with porcine ear skin. We found that the TAA-SLN gel possessed good stability, rheological properties, and high electric conductance. Transdermal penetration of TAA from TAA-SLN gel cross the skin tissue was significantly enhanced by iontophoresis. The enhancement of the cumulative penetration amount and the steady-state penetration flux of the penetrated drug were related to the particle size of TAA-SLN and the characteristics of the applied pulse electric current, such as density, frequency, and on/off interval ratio. These results indicated that SLN carbopol gel could be used as a vehicle for transdermal iontophoretic drug delivery under suitable electric conditions.
authors.affiliation: College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China. wliu@mail.hust.edu.cn
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Meiling
authors.initials: M
authors.lastname: Hu
authors.forename: Wenshuang
authors.initials: W
authors.lastname: Liu
authors.forename: Chengbin
authors.initials: C
authors.lastname: Xue
authors.forename: Huibi
authors.initials: H
authors.lastname: Xu
authors.forename: XiangLiang
authors.initials: X
authors.lastname: Yang
mesh_terms: D000180:Acrylic Resins; D000279:Administration, Cutaneous; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D004356:Drug Storage; D004431:Ear, External / Q000378:metabolism; D004553:Electric Conductivity; D005782:Gels; D066298:In Vitro Techniques; D007478:Iontophoresis; D008055:Lipids / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011145:Polyvinyls / Q000737:chemistry*; D012212:Rheology; D012869:Skin Absorption; D013499:Surface Properties; D013552:Swine; D014222:Triamcinolone Acetonide / Q000008:administration & dosage*
chemical_list: D000180:Acrylic Resins; D000893:Anti-Inflammatory Agents; D005782:Gels; D008055:Lipids; D011145:Polyvinyls; C006912:carboxypolymethylene; D014222:Triamcinolone Acetonide