title: Seleninate in place of phosphate: irreversible inhibition of protein tyrosine phosphatases.
abstract: A homotyrosine based seleninic acid irreversibly inhibits protein tyrosine phosphatases by forming a covalent selenosulfide linkage with the active site cysteine sulfhydryl specifically. The details of the event are revealed by model synthetic studies and by kinetic, mass spectrometric, and crystallographic characterization.
authors.affiliation: Department of Chemistry and Chemical Biology, Rutgers The State University of New Jersey, Piscataway, New Jersey 08854, USA.
authors.forename: Mohannad
authors.initials: M
authors.lastname: Abdo
authors.forename: Sijiu
authors.initials: S
authors.lastname: Liu
authors.forename: Bo
authors.initials: B
authors.lastname: Zhou
authors.forename: Chad D
authors.initials: CD
authors.lastname: Walls
authors.forename: Li
authors.initials: L
authors.lastname: Wu
authors.forename: Spencer
authors.initials: S
authors.lastname: Knapp
authors.forename: Zhong-Yin
authors.initials: ZY
authors.lastname: Zhang
mesh_terms: D020240:Apraxia, Ideomotor; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D010710:Phosphates / Q000737:chemistry*; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D018036:Selenium Compounds / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D010710:Phosphates; D018036:Selenium Compounds; D017027:Protein Tyrosine Phosphatases