title: The nuclear receptor tailless is required for neurogenesis in the adult subventricular zone.
abstract: The tailless (Tlx) gene encodes an orphan nuclear receptor that is expressed by neural stem/progenitor cells in the adult brain of the subventricular zone (SVZ) and the dentate gyrus (DG). The function of Tlx in neural stem cells of the adult SVZ remains largely unknown. We show here that in the SVZ of the adult brain Tlx is exclusively expressed in astrocyte-like B cells. An inducible mutation of the Tlx gene in the adult brain leads to complete loss of SVZ neurogenesis. Furthermore, analysis indicates that Tlx is required for the transition from radial glial cells to astrocyte-like neural stem cells. These findings demonstrate the crucial role of Tlx in the generation and maintenance of NSCs in the adult SVZ in vivo.
authors.affiliation: Division of Molecular Biology of the Cell I, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
authors.forename: Hai-Kun
authors.initials: HK
authors.lastname: Liu
authors.forename: Thorsten
authors.initials: T
authors.lastname: Belz
authors.forename: Dagmar
authors.initials: D
authors.lastname: Bock
authors.forename: Andrea
authors.initials: A
authors.lastname: Takacs
authors.forename: Hui
authors.initials: H
authors.lastname: Wu
authors.forename: Peter
authors.initials: P
authors.lastname: Lichter
authors.forename: Minqiang
authors.initials: M
authors.lastname: Chai
authors.forename: Günther
authors.initials: G
authors.lastname: Schütz
mesh_terms: D000818:Animals; D002552:Cerebral Ventricles / Q000166:cytology*; D051379:Mice; D039902:Multipotent Stem Cells / Q000166:cytology; D009474:Neurons / Q000166:cytology*; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000502:physiology*
chemical_list: C490258:Nr2e1 protein, mouse; D018160:Receptors, Cytoplasmic and Nuclear
references.citation: Nature. 2004 Jan 1;427(6969):78-83
references.pmid: 14702088
references.citation: Curr Top Dev Biol. 2005;69:67-99
references.pmid: 16243597
references.citation: J Neurosci. 1997 Jul 1;17(13):5046-61
references.pmid: 9185542
references.citation: Nature. 1997 Dec 4;390(6659):515-7
references.pmid: 9394001
references.citation: Nature. 2008 Feb 21;451(7181):1004-7
references.pmid: 18235445
references.citation: Development. 1995 Mar;121(3):839-53
references.pmid: 7720587
references.citation: Trends Neurosci. 2003 Mar;26(3):125-31
references.pmid: 12591214
references.citation: Neuron. 2006 Jul 20;51(2):187-99
references.pmid: 16846854
references.citation: Nat Neurosci. 2003 Nov;6(11):1127-34
references.pmid: 14583753
references.citation: Nat Neurosci. 2004 Nov;7(11):1233-41
references.pmid: 15494728
references.citation: Science. 2000 Feb 25;287(5457):1433-8
references.pmid: 10688783
references.citation: Science. 2007 Mar 2;315(5816):1243-9
references.pmid: 17303719
references.citation: Nat Neurosci. 2005 Jul;8(7):865-72
references.pmid: 15951811
references.citation: J Neurosci. 2002 Jan 15;22(2):437-45
references.pmid: 11784788
references.citation: Curr Opin Cell Biol. 2006 Dec;18(6):704-9
references.pmid: 17046226
references.citation: Cell Prolif. 1994 May;27(5):279-89
references.pmid: 10465012
references.citation: Neuron. 2004 Mar 25;41(6):881-90
references.pmid: 15046721
references.citation: Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):111-6
references.pmid: 16373498
references.citation: J Neurosci. 2002 Feb 1;22(3):629-34
references.pmid: 11826091
references.citation: Eur J Neurosci. 2007 Oct;26(8):2222-7
references.pmid: 17953618
references.citation: Neuron. 2002 Dec 19;36(6):1021-34
references.pmid: 12495619
references.citation: Genesis. 2000 Nov-Dec;28(3-4):147-55
references.pmid: 11105057
references.citation: J Dent Res. 1981 Aug;60 Spec No C:1611-20
references.pmid: 6943171
references.citation: Genes Dev. 2006 May 15;20(10):1308-20
references.pmid: 16702404
references.citation: Cell. 1999 Jan 8;96(1):25-34
references.pmid: 9989494
references.citation: Nat Genet. 1999 Jan;21(1):70-1
references.pmid: 9916792
references.citation: Cell. 1999 Jun 11;97(6):703-16
references.pmid: 10380923
references.citation: J Neurosci. 2004 Sep 22;24(38):8333-45
references.pmid: 15385616
references.citation: Science. 2007 Jul 20;317(5836):381-4
references.pmid: 17615304
references.citation: J Neurosci. 2007 Apr 18;27(16):4297-302
references.pmid: 17442813
references.citation: Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17528-32
references.pmid: 15574494