Association of cyclooxygenase-2 and interleukin-1 receptor antagonist gene polymorphisms with the time interval between labor induction and delivery.
OBJECTIVE
The interval between induction and delivery may change in association with different polymorphisms in genes regulating inflammation.


METHODS
Seventy participants in a trial for induction of labor at term were tested for a -765 G>C cyclooxygenase-2 and an intron 2 length interleukin-1 receptor antagonist gene polymorphism.


RESULTS
The interleukin-1 receptor antagonist allele 2 frequency was 33.3% in the 12 women who delivered at < or =10 hours, compared with 13.8% in those delivered >10 hours (P = .03). The interleukin-1 receptor antagonist allele 2 frequency was 25.0% in women induced because of postdates as opposed to 7.9% induced for other indications (P = .01). The cyclooxygenase-2 allele C frequency was 30.0% in 35 women delivered at < or =20 hours as opposed to 11.4% in women delivered at >20 hours (P = .01). The cyclooxygenase-2 allele C frequency was 26.9% in 26 subjects induced because of postdates as opposed to 13.6% induced for other indications (P = .07).


CONCLUSIONS
Cyclooxygenase-2 allele C and interleukin-1 receptor antagonist allele 2 are associated with a reduced time interval from labor induction to delivery.
Skupski
Daniel W
DW
Department of Obstetrics and Gynecology, New York Hospital Queens, New York, NY, USA.
Normand
Neil
N
Eglinton
Gary S
GS
Witkin
Steven S
SS
D000328:Adult; D020070:Cervical Ripening / Q000502:physiology*; D051546:Cyclooxygenase 2 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D007751:Labor, Induced; D016104:Oligohydramnios / Q000628:therapy; D011110:Polymorphism, Genetic; D011247:Pregnancy; D013997:Time Factors; D014219:Trial of Labor
D053590:Interleukin 1 Receptor Antagonist Protein; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human