Vaccine therapy for P. acnes-associated diseases.
Recent studies have afforded abundant evidences showing that Propionibacterium acnes (P. acnes) is involved not only in acne vulgaris, but also in many diseases, including endocarditis, endophthalmitis, osteomyelitis, joint, nervous system, cranial neurosurgery infections, and implanted biomaterial contamination. In spite of a range of P. acnes pathogenicity, its vaccine therapies have been studied much less intensively than antibiotic therapies which have been mainstay of treatment for P. acnes-associated diseases. Therefore, we have recently developed effective vaccines for P. acnes-associated inflammatory acne, consisting of a cell wall-anchored sialidase of P. acnes or killed-whole organism of P. acnes. Our data strongly show that immunization of ICR mice with the vaccines provides in vivo protective immunity against P. acnes challenge and decreases P. acnes-induced elevation of cytokine production. This review highlights the potential functions of killed P. acnes- and sialidase-based vaccines as novel treatments for P. acnes-associated diseases.
Nakatsuji
Teruaki
T
Department of Medicine, Division of Dermatology, University of California, San Diego, CA 92161, USA.
Rasochova
Lada
L
Huang
Chun-Ming
CM
D000152:Acne Vulgaris / Q000188:drug therapy* / Q000382:microbiology; D000818:Animals; D001428:Bacterial Vaccines / Q000627:therapeutic use*; D004195:Disease Models, Animal; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D051379:Mice; D009439:Neuraminidase / Q000276:immunology*; D011425:Propionibacterium acnes / Q000201:enzymology / Q000276:immunology* / Q000472:pathogenicity; D015164:Vaccines, Inactivated / Q000627:therapeutic use
D001428:Bacterial Vaccines; D015164:Vaccines, Inactivated; D009439:Neuraminidase