Cerebral aspergillosis caused by Aspergillus ustus following orthotopic heart transplantation: case report and review of the literature.
This report describes the first case of cerebral aspergillosis in a heart transplantation patient caused by Aspergillus ustus and reviews 15 previously reported cases of invasive aspergillosis in immunocompromised hosts caused by this mold. The utility of molecular analysis for the identification of unusual fungal pathogens is also described. The refractory nature of A. ustus to treatment is similar to other Aspergillus species and treatment options are reviewed.
Florescu
Diana F
DF
Section of Infectious Diseases, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5400, USA. dflorescu@unmc.edu
Iwen
Peter C
PC
Hill
Lisa A
LA
Dumitru
Ioana
I
Quader
Mohammed A
MA
Kalil
Andre C
AC
Freifeld
Alison G
AG
D000328:Adult; D001228:Aspergillosis / Q000188:drug therapy / Q000382:microbiology*; D001230:Aspergillus / Q000302:isolation & purification*; D001927:Brain Diseases / Q000188:drug therapy / Q000382:microbiology*; D017809:Fatal Outcome; D016027:Heart Transplantation; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D011183:Postoperative Complications