Novel bioconjugates of aminolevulinic acid with vitamins.
5-Aminolevulinic acid (ALA) and derivatives thereof have been successfully used in photodynamic cancer therapy (PDT). The synthesis of novel bioconjugates combining ALA with two lipophilic and one hydrophilic vitamins is reported. The new bioconjugates allow studying the potential synergies between the two components in PDT. The synthetic methodology is robust giving the bioconjugates in good to satisfactory yield.
Vallinayagam
Ramakrishnan
R
Institut de Chimie, Université de Neuchâtel, Rue Emile-Argand, 11, PO 158, Neuchatel, Switzerland.
Weber
Joanne
J
Neier
Reinhard
R
D000577:Amides / Q000737:chemistry; D000622:Aminolevulinic Acid / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D014815:Vitamins / Q000737:chemistry*
D000577:Amides; D014815:Vitamins; D000622:Aminolevulinic Acid