title: Design, synthesis, structure-activity relationship and antibacterial activity series of novel imidazo fused quinolone carboxamides.
abstract: A series of novel 7,8 and 1,8 imidazo fused quinolone carboxamides are synthesized and evaluated against antibacterial activity. 1,8 Imidazo fused quinolones exhibit moderate antibacterial activity. Molecular modeling studies were carried out to optimize the pharmacophore.
authors.affiliation: Fluoroorganic Division, Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad, Andhrapradesh 500007, India.
authors.forename: G Venkat
authors.initials: GV
authors.lastname: Reddy
authors.forename: S Ravi
authors.initials: SR
authors.lastname: Kanth
authors.forename: D
authors.initials: D
authors.lastname: Maitraie
authors.forename: B
authors.initials: B
authors.lastname: Narsaiah
authors.forename: P Shanthan
authors.initials: PS
authors.lastname: Rao
authors.forename: K Hara
authors.initials: KH
authors.lastname: Kishore
authors.forename: U S N
authors.initials: US
authors.lastname: Murthy
authors.forename: B
authors.initials: B
authors.lastname: Ravi
authors.forename: B Ashok
authors.initials: BA
authors.lastname: Kumar
authors.forename: T
authors.initials: T
authors.lastname: Parthasarathy
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D015195:Drug Design; D008826:Microbial Sensitivity Tests; D015363:Quinolones / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D000900:Anti-Bacterial Agents; D015363:Quinolones