[Pleiotropic effects of statins].
Systematization of pleiotropic actions of statins is presented with special stress on effects important for prevention of atherosclerotic diseases, nonatherosclerotic cardiovascular diseases, and diseases of noncardiovascular origin. Dependence of pleiotropic effects of statins on dose and duration of administration is shown. The review contains data on novel studies of pleiotropic effects favorably affecting endothelial function, oxidative stress, arterial pressure, angiogenesis, heart failure, and disturbances of cardiac rhythm.
Aronov
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D002352:Carrier Proteins / Q000187:drug effects*; D016207:Cytokines / Q000187:drug effects*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D009203:Myocardial Infarction / Q000517:prevention & control
D002352:Carrier Proteins; D016207:Cytokines; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; C066845:pleiotrophin