title: Aquatic toxicity and biodegradability of advanced cationic surfactant APA-22 compatible with the aquatic environment.
abstract: Cationic surfactant is a chemical substance used in hair conditioner, fabric softener and other household products. By investigating the relationship between the aquatic toxicity and the chemical structures of two types of mono alkyl cationic surfactants, alkyl trimethylammonium salts and alkyl dimethylamine salts, we have found that the C22 alkyl chain length is effective to reduce the toxicity. Besides, we have recognized that the amidopropyl functional group contributes to the enhanced biodegradability by investigating the biodegradation trend of (alkylamidopropyl)dimethylamine salt (alkyl chain length: C18). Based on these findings, we have developed mono alkyl cationic surfactant called APA-22, N-[3-(dimethylamino)propyl]docosanamide salt. APA-22 is formed by the C22 alkyl chain, amidopropyl functional group and di-methyltertiary amine group. We evaluated the aerobic and anaerobic biodegradability of APA-22 by two standard methods (OECD Test Guideline 301B and ECETOC technical document No.28) and found that this substance was degraded rapidly in both conditions. The toxicity to algae, invertebrate and fish of this substance are evaluated by using OECD Test Guideline 201, 202 and 203, respectively. All acute toxicity values are >1 mg/L, which indicates that environmental toxicity of this substance is relatively less toxic to aquatic organism. In addition, we estimated the biodegradation pathway of APA-22 and observed the complete disappearance of APA-22 and its intermediates during the test periods. Based on the environmental data provided above, we concluded that APA22 is more compatible with the aquatic environment compared to other cationic surfactants with mono long alkyl chain.
authors.affiliation: Safety Science Research Laboratories, Kao Corporation, Tochigi, Japan. Yamane.masayuki@kao.co.jp
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yamane
authors.forename: Takamasa
authors.initials: T
authors.lastname: Toyo
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Inoue
authors.forename: Takaya
authors.initials: T
authors.lastname: Sakai
authors.forename: Youhei
authors.initials: Y
authors.lastname: Kaneko
authors.forename: Naohiro
authors.initials: N
authors.lastname: Nishiyama
mesh_terms: D000577:Amides / Q000378:metabolism* / Q000633:toxicity*; D000818:Animals; D001673:Biodegradation, Environmental; D002412:Cations / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D003621:Daphnia / Q000187:drug effects; D056890:Eukaryota / Q000187:drug effects; D005399:Fishes; D006203:Hair Preparations / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D015394:Molecular Structure; D013501:Surface-Active Agents / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity*; D023382:Toxicity Tests, Acute; D014867:Water / Q000737:chemistry
chemical_list: D000577:Amides; D002412:Cations; D006203:Hair Preparations; D013501:Surface-Active Agents; D014867:Water; C533672:N-(3-(dimethylamino)propyl)docosanamide