From yeast killer toxins to antibiobodies and beyond.
Antibiobodies are paradigmatic of yeast killer toxin (KT)-like antibodies (KAbs) mimicking the antimicrobial activity of KTs in the frame of the yeast killer phenomenon. Polyclonal, monoclonal and recombinant anti-idiotypic antibiobodies (anti-idiotypic KAbs), internal images of a wide-spectrum KT produced by the yeast Pichia anomala (PaKT), have been produced by immunization with the idiotype of a PaKT-neutralizing monoclonal antibody. Anti-idiotypic KAbs showed microbicidal activity against eukaryotic and prokaryotic pathogenic agents through the interaction with specific KT receptors (KTRs), putatively constituted by beta-glucans. Natural KAbs have been found in animals and humans experimentally or naturally infected by KTR-bearing microorganisms. Recombinant KAb-derived synthetic killer peptides showed further antiviral and immunomodulatory activities. The perspectives of KAbs and killer peptides as potential sources of novel therapeutic agents, and of KTRs and idiotypes as vaccines against infectious diseases are discussed.
Magliani
Walter
W
Sezione di Microbiologia, Dipartimento di Patologia e Medicina di Laboratorio, Università degli Studi di Parma, Parma, Italy.
Conti
Stefania
S
Travassos
Luiz R
LR
Polonelli
Luciano
L
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology / Q000494:pharmacology; D000908:Antibodies, Fungal / Q000276:immunology* / Q000494:pharmacology; D003141:Communicable Diseases / Q000188:drug therapy*; D006801:Humans; D055646:Killer Factors, Yeast / Q000235:genetics / Q000276:immunology* / Q000494:pharmacology*; D010455:Peptides / Q000235:genetics / Q000276:immunology / Q000494:pharmacology; D010843:Pichia / Q000235:genetics / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D000908:Antibodies, Fungal; D055646:Killer Factors, Yeast; D010455:Peptides