Sequence variant on 8q24 confers susceptibility to urinary bladder cancer.
We conducted a genome-wide SNP association study on 1,803 urinary bladder cancer (UBC) cases and 34,336 controls from Iceland and The Netherlands and follow up studies in seven additional case-control groups (2,165 cases and 3,800 controls). The strongest association was observed with allele T of rs9642880 on chromosome 8q24, 30 kb upstream of MYC (allele-specific odds ratio (OR) = 1.22; P = 9.34 x 10(-12)). Approximately 20% of individuals of European ancestry are homozygous for rs9642880[T], and their estimated risk of developing UBC is 1.49 times that of noncarriers. No association was observed between UBC and the four 8q24 variants previously associated with prostate, colorectal and breast cancers, nor did rs9642880 associate with any of these three cancers. A weaker signal, but nonetheless of genome-wide significance, was captured by rs710521[A] located near TP63 on chromosome 3q28 (allele-specific OR = 1.19; P = 1. 15 x 10(-7)).
Kiemeney
Lambertus A
LA
Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.
Thorlacius
Steinunn
S
Sulem
Patrick
P
Geller
Frank
F
Aben
Katja K H
KK
Stacey
Simon N
SN
Gudmundsson
Julius
J
Jakobsdottir
Margret
M
Bergthorsson
Jon T
JT
Sigurdsson
Asgeir
A
Blondal
Thorarinn
T
Witjes
J Alfred
JA
Vermeulen
Sita H
SH
Hulsbergen-van de Kaa
Christina A
CA
Swinkels
Dorine W
DW
Ploeg
Martine
M
Cornel
Erik B
EB
Vergunst
Henk
H
Thorgeirsson
Thorgeir E
TE
Gudbjartsson
Daniel
D
Gudjonsson
Sigurjon A
SA
Thorleifsson
Gudmar
G
Kristinsson
Kari T
KT
Mouy
Magali
M
Snorradottir
Steinunn
S
Placidi
Donatella
D
Campagna
Marcello
M
Arici
Cecilia
C
Koppova
Kvetoslava
K
Gurzau
Eugene
E
Rudnai
Peter
P
Kellen
Eliane
E
Polidoro
Silvia
S
Guarrera
Simonetta
S
Sacerdote
Carlotta
C
Sanchez
Manuel
M
Saez
Berta
B
Valdivia
Gabriel
G
Ryk
Charlotta
C
de Verdier
Petra
P
Lindblom
Annika
A
Golka
Klaus
K
Bishop
D Timothy
DT
Knowles
Margaret A
MA
Nikulasson
Sigfus
S
Petursdottir
Vigdis
V
Jonsson
Eirikur
E
Geirsson
Gudmundur
G
Kristjansson
Baldvin
B
Mayordomo
Jose I
JI
Steineck
Gunnar
G
Porru
Stefano
S
Buntinx
Frank
F
Zeegers
Maurice P
MP
Fletcher
Tony
T
Kumar
Rajiv
R
Matullo
Giuseppe
G
Vineis
Paolo
P
Kiltie
Anne E
AE
Gulcher
Jeffrey R
JR
Thorsteinsdottir
Unnur
U
Kong
Augustine
A
Rafnar
Thorunn
T
Stefansson
Kari
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001483:Base Sequence; D016022:Case-Control Studies; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D001749:Urinary Bladder Neoplasms / Q000235:genetics*
D005819:Genetic Markers
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