title: Synthesis and antiproliferative activity of unnatural enantiomers of 7-epi-goniofufurone and crassalactone C.
abstract: A facile synthesis of 7-epi-(-)-goniofufurone as well as the first synthesis of (-)-crassalactone C was achieved starting from D-xylose. A comparison of their in vitro antitumour activities with those observed for the corresponding naturally occurring enantiomers was provided.
authors.affiliation: Department of Chemistry, Faculty of Sciences, University of Novi Sad, Trg D. Obradovića 3, 21000 Novi Sad, Serbia. popsavin@ih.ns.ac.yu
authors.forename: Velimir
authors.initials: V
authors.lastname: Popsavin
authors.forename: Goran
authors.initials: G
authors.lastname: Benedeković
authors.forename: Bojana
authors.initials: B
authors.lastname: Srećo
authors.forename: Mirjana
authors.initials: M
authors.lastname: Popsavin
authors.forename: Jovana
authors.initials: J
authors.lastname: Francuz
authors.forename: Vesna
authors.initials: V
authors.lastname: Kojić
authors.forename: Gordana
authors.initials: G
authors.lastname: Bogdanović
mesh_terms: D029061:Annonaceae / Q000737:chemistry; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D019169:Jurkat Cells; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured; D014994:Xylose / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; C524151:crassalactone C; C073080:7-goniofufurone; D014994:Xylose