title: Jerantinines A-G, cytotoxic Aspidosperma alkaloids from Tabernaemontana corymbosa.
abstract: Seven new indole alkaloids of the Aspidosperma type, jerantinines A-G (1-7), were isolated from a leaf extract of the Malayan Tabernaemontana corymbosa. The structures were established using NMR and MS analysis. Five of the alkaloids isolated and two derivatives (1-5, 8, 9) displayed pronounced in vitro cytotoxicity against human KB cells (IC50 < 1 microg/mL).
authors.affiliation: Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Kuan-Hon
authors.initials: KH
authors.lastname: Lim
authors.forename: Osamu
authors.initials: O
authors.lastname: Hiraku
authors.forename: Kanki
authors.initials: K
authors.lastname: Komiyama
authors.forename: Toh-Seok
authors.initials: TS
authors.lastname: Kam
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007624:KB Cells; D008296:Malaysia; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D030014:Tabernaemontana / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D026121:Indole Alkaloids