title: Screening, treatment, and prostate cancer mortality in the Seattle area and Connecticut: fifteen-year follow-up.
abstract: BACKGROUND
  Prior to introduction of the prostate-specific antigen (PSA) test, the Seattle-Puget Sound and Connecticut Surveillance, Epidemiology and End Results (SEER) areas had similar prostate cancer mortality rates. Early in the PSA era (1987-1990), men in the Seattle area were screened and treated more intensively for prostate cancer than men in Connecticut.
  
  
  OBJECTIVE
  We previously reported more intensive screening and treatment early in the PSA era did not lower prostate cancer mortality through 11 years and now extend follow-up to 15 years.
  
  
  METHODS
  Natural experiment comparing two fixed population-based cohorts.
  
  
  METHODS
  Male Medicare beneficiaries ages 65-79 from the Seattle (N = 94,900) and Connecticut (N = 120,621) SEER areas, followed from 1987-2001.
  
  
  METHODS
  Rates of prostate cancer screening; treatment with radical prostatectomy, external beam radiotherapy, and androgen deprivation therapy; and prostate cancer-specific mortality.
  
  
  RESULTS
  The 15-year cumulative incidences of radical prostatectomy and radiotherapy through 2001 were 2.84% and 6.02%, respectively, for Seattle cohort members, compared to 0.56% and 5.07% for Connecticut cohort members (odds ratio 5.20, 95% confidence interval 3.22 to 8.42 for surgery and odds ratio 1.24, 95% confidence interval 0.98 to 1.58 for radiation). The cumulative incidence of androgen deprivation therapy from 1991-2001 was 4.78% for Seattle compared to 6.13% for Connecticut (odds ratio 0.77, 95% confidence interval 0.67 to 0.87). The adjusted rate ratio of prostate cancer mortality through 2001 was 1.02 (95% C.I. 0.96 to 1.09) in Seattle versus Connecticut.
  
  
  CONCLUSIONS
  Among men aged 65 or older, more intensive prostate cancer screening early in the PSA era and more intensive treatment particularly with radical prostatectomy over 15 years of follow-up were not associated with lower prostate cancer-specific mortality.
authors.affiliation: The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
authors.forename: Grace
authors.initials: G
authors.lastname: Lu-Yao
authors.forename: Peter C
authors.initials: PC
authors.lastname: Albertsen
authors.forename: Janet L
authors.initials: JL
authors.lastname: Stanford
authors.forename: Therese A
authors.initials: TA
authors.lastname: Stukel
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Walker-Corkery
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Barry
mesh_terms: D000368:Aged; D003237:Connecticut / Q000453:epidemiology; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009026:Mortality / Q000639:trends; D010818:Practice Patterns, Physicians' / Q000639:trends*; D011468:Prostatectomy / Q000639:trends; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000628:therapy; D018714:Radiotherapy, Adjuvant / Q000639:trends; D018426:SEER Program; D014861:Washington / Q000453:epidemiology
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