title: [Preparation and dissolution in vitro of esomeprazole zinc solid dispersion].
abstract: OBJECTIVE
  To prepare esomeprazole zinc solid dispersion (EZSD) to improve its dissolution in vitro.
  
  
  METHODS
  EZ solid dispersions were prepared by solvent method using PVP K30 and PEG 6000 as carriers. The in vitro dissolution of the EZ solid dispersions enteric capsules was analyzed. The existence status of EZ in the carrier was determined by differential scanning calorimeter (DSC).
  
  
  RESULTS
  The dissolution of EZ increased first and then decreased with the increase of the ratio of carries. The dissolution of the solid dispersions with PEG 6000 as carrier was faster than that with PVP K30 as carrier. The EZ was amorphously dispersed in the solid dispersion.
  
  
  CONCLUSIONS
  The in vitro dissolution rate of EZ is significantly improved by the solid dispersion.
authors.affiliation: Institute of Chemical Engineering, Sichuan University, Chengdu 610065, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Xie
authors.forename: Yong-mei
authors.initials: YM
authors.lastname: Xie
authors.forename: Hang
authors.initials: H
authors.lastname: Song
authors.forename: Xin
authors.initials: X
authors.lastname: Song
authors.forename: Yuan-jie
authors.initials: YJ
authors.lastname: Zuo
authors.forename: Yu
authors.initials: Y
authors.lastname: Qiu
authors.forename: Xiao-hai
authors.initials: XH
authors.lastname: Tang
mesh_terms: D004337:Drug Carriers; D064098:Esomeprazole / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D011205:Povidone / Q000737:chemistry; D054328:Proton Pump Inhibitors / Q000138:chemical synthesis / Q000737:chemistry*; D012995:Solubility; D015032:Zinc / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D054328:Proton Pump Inhibitors; D011092:Polyethylene Glycols; D011205:Povidone; D015032:Zinc; D064098:Esomeprazole