Programmed regulation of conformational switching in diagnostic biomolecular automata using error control molecules.
We aim to present novel biomolecular automata for transcriptome diagnosis. We already proposed several biomolecular probes for the prediction of oral squamous cell carcinoma as a model case and evaluated the system noise and sensitivity. Here we introduce an error control element and discuss the specificity of the system.
Hirabayashi
Miki
M
Department of Quantum Engineering and Systems Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-8656, Japan. miki@crimson.q.t.u-tokyo.ac.jp
Ohashi
Hirotada
H
Kubo
Tai
T
D052157:Aptamers, Nucleotide / Q000737:chemistry*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000235:genetics*; D005456:Fluorescent Dyes / Q000737:chemistry; D005786:Gene Expression Regulation; D006801:Humans; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000235:genetics*; D009690:Nucleic Acid Conformation; D015345:Oligonucleotide Probes / Q000737:chemistry*; D012333:RNA, Messenger / Q000032:analysis*; D012394:Rosaniline Dyes / Q000737:chemistry; D012680:Sensitivity and Specificity; D014158:Transcription, Genetic
D052157:Aptamers, Nucleotide; D005456:Fluorescent Dyes; D015345:Oligonucleotide Probes; D012333:RNA, Messenger; D012394:Rosaniline Dyes; C005095:malachite green