title: [A case of toxic epidermal necrolysis with severe intestinal manifestation].
abstract: TEN is a severe dermatological disorder characterized by extended epidermal necrosis. Disseminated mucosal erosions have been occasionally reported to occur in the gastrointestinal tract. We report a case of toxic epidermal necrolysis (TEN) with severe intestinal manifestation. A 52-year-old woman was admitted with high fever, skin eruption and severe diarrhea. She was diagnosed as toxic epidermal necrolysis (TEN), which was most likely due to nonsteroidal anti-inflammatory drugs (NSAIDs). After skin lesion recovered, fever and bloody diarrhea went on. Colonoscopy and X-ray revealed lead-pipe like stenotic long loops which was caused by erosion and sublation of whole mucosa of large intestinum, and severe stenosis of ileum end. The ileo-cecal region was resected on the 216(th) hospital day. Pathological examination showed sublation of mucoepithelium and inflammatory change in the muco-submucosal layer, but muscular layers of mucosa remained intact. Pathologically, the intestinal lesion resemble the changes in the early skin lesions and seems to be part of the systemic lesion of TEN.
authors.affiliation: Department of Gastroenterology, Tokushima Prefectural Central Hospital, Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Otomi
authors.forename: Mitsuyasu
authors.initials: M
authors.lastname: Yano
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Aoki
authors.forename: Kouji
authors.initials: K
authors.lastname: Takahashi
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Omoya
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Jiro
authors.initials: J
authors.lastname: Nakamoto
authors.forename: Koichi
authors.initials: K
authors.lastname: Kataoka
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Yagi
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Yamamoto
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D007422:Intestines / Q000473:pathology*; D013262:Stevens-Johnson Syndrome / Q000209:etiology / Q000473:pathology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal