title: C-Reactive protein, insulin resistance, and metabolic syndrome in a population with a high burden of subclinical infection: insights from the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study.
abstract: OBJECTIVE
  To explore relationships between C-reactive protein (CRP), subclinical infection, insulin resistance, and metabolic syndrome.
  
  
  METHODS
  Data from 1,174 Eskimos, aged >/=18 years, from the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study were analyzed; 40 participants with diabetes were eliminated. Baseline assessment included interviews, physical exam, and blood and urine sampling. Metabolic syndrome was assessed using Adult Treatment Panel III criteria. CRP and antibodies to common pathogens were measured.
  
  
  RESULTS
  Although CRP was related in univariate analyses to insulin resistance and metabolic syndrome, relations were attenuated or eliminated after adjustment for relevant covariates. CRP was not higher among those with impaired fasting glucose (IFG), and pathogen burden was not related to insulin resistance, metabolic syndrome, or IFG.
  
  
  CONCLUSIONS
  Pathogen burden and inflammation do not seem to be related to insulin resistance, metabolic syndrome, or IFG in this population. The inflammatory process may reflect insulin resistance or its correlates but most likely is not causative.
authors.affiliation: MedStar Research Institute, Hyattsville, Maryland, USA. barbara.v.howard@medstar.net
authors.forename: Barbara V
authors.initials: BV
authors.lastname: Howard
authors.forename: Lyle
authors.initials: L
authors.lastname: Best
authors.forename: Anthony
authors.initials: A
authors.lastname: Comuzzie
authors.forename: Sven O E
authors.initials: SO
authors.lastname: Ebbesson
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Epstein
authors.forename: Richard R
authors.initials: RR
authors.lastname: Fabsitz
authors.forename: Wm James
authors.initials: WJ
authors.lastname: Howard
authors.forename: Angela
authors.initials: A
authors.lastname: Silverman
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.forename: Jianhui
authors.initials: J
authors.lastname: Zhu
authors.forename: Jason
authors.initials: J
authors.lastname: Umans
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000032:analysis*; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000209:etiology / Q000276:immunology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000453:epidemiology* / Q000209:etiology; D007333:Insulin Resistance / Q000276:immunology / Q000502:physiology*; D004930:Inuit; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000276:immunology; D008875:Middle Aged
chemical_list: D002097:C-Reactive Protein
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