Investigation of the carbopol gel of solid lipid nanoparticles for the transdermal iontophoretic delivery of triamcinolone acetonide acetate.
The purpose of this study was to investigate solid lipid nanoparticles (SLN) hydrogel for transdermal iontophoretic drug delivery. Triamcinolone acetonide acetate (TAA), a glucocorticoids compound, was employed as the model drug. SLN containing the drug triamcinolone acetonide acetate (TAA-SLN) and their carbopol gel with stable physicochemical properties were prepared. The use of TAA-SLN carbopol gel as a vehicle for the transdermal iontophoretic delivery of TAA was evaluated in vitro using horizontal diffusion cells fitted with porcine ear skin. We found that the TAA-SLN gel possessed good stability, rheological properties, and high electric conductance. Transdermal penetration of TAA from TAA-SLN gel cross the skin tissue was significantly enhanced by iontophoresis. The enhancement of the cumulative penetration amount and the steady-state penetration flux of the penetrated drug were related to the particle size of TAA-SLN and the characteristics of the applied pulse electric current, such as density, frequency, and on/off interval ratio. These results indicated that SLN carbopol gel could be used as a vehicle for transdermal iontophoretic drug delivery under suitable electric conditions.
Liu
Wei
W
College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China. wliu@mail.hust.edu.cn
Hu
Meiling
M
Liu
Wenshuang
W
Xue
Chengbin
C
Xu
Huibi
H
Yang
XiangLiang
X
D000180:Acrylic Resins; D000279:Administration, Cutaneous; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D004356:Drug Storage; D004431:Ear, External / Q000378:metabolism; D004553:Electric Conductivity; D005782:Gels; D066298:In Vitro Techniques; D007478:Iontophoresis; D008055:Lipids / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011145:Polyvinyls / Q000737:chemistry*; D012212:Rheology; D012869:Skin Absorption; D013499:Surface Properties; D013552:Swine; D014222:Triamcinolone Acetonide / Q000008:administration & dosage*
D000180:Acrylic Resins; D000893:Anti-Inflammatory Agents; D005782:Gels; D008055:Lipids; D011145:Polyvinyls; C006912:carboxypolymethylene; D014222:Triamcinolone Acetonide