Pro-inflammatory and anti-inflammatory cytokines in acute ischemic stroke and their relation to early neurological deficit and stroke outcome.
OBJECTIVE
Our aim was to explore (i) the difference in concentration of IL-6, TNF-alpha and IL-10 between acute ischemic stroke patients and control individuals; (ii) the association of plasma cytokine concentration with stroke severity at admission assessed by NIHSS and stroke outcome in 90 days assessed by Barthel index (BI) and modified Rankin scale (mRS).


METHODS
Study included 68 stroke patients admitted within 12 h of symptoms onset and 71 controls.


RESULTS
IL-6 was increased in patients relative to controls (P=0.035) and this increase was associated with severe stroke (P=0.007) and worse outcome (P=0.030 and 0.019; assessed by BI and mRS, respectively), whereas IL-10 was decreased (P=0.044) and associated with better outcome (P=0.043). TNF-alpha did not differ between studied groups (P=0.302).


CONCLUSIONS
Increased IL-6 and reduced IL-10 concentrations are present in early stroke period and are associated with a degree of neurological deficit and/or stroke outcome.
Basic Kes
Vanja
V
University Department of Neurology, Sestre milosrdnice University Hospital, Zagreb, Croatia.
Simundic
Ana-Maria
AM
Nikolac
Nora
N
Topic
Elizabeta
E
Demarin
Vida
V
D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000097:blood* / Q000150:complications* / Q000628:therapy; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D003710:Demography; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D020521:Stroke / Q000097:blood* / Q000150:complications* / Q000628:therapy; D016896:Treatment Outcome
D016207:Cytokines; D018836:Inflammation Mediators