Respiratory impedance and response to salbutamol in healthy Vietnamese children.
A high incidence of childhood asthma has been reported in Ha Noi, Viet Nam, indicating a need to document lung function in these children. The degree of airway obstruction and reversibility may be evaluated from the forced oscillation assessment of respiratory resistance to reactance (Rrs, Xrs). Appropriate controls are necessary for a proper interpretation of patients. The aim of the study was to provide reference values on Rrs and Xrs and response to salbutamol in healthy Vietnamese children. One hundred seventy-five children aged 6-11 year recruited from one public school in Ha Noi were studied. Measurements were obtained at baseline and after 200 microg inhaled salbutamol. Significant correlations were disclosed between Rrs or Xrs and standing height (P < 0.0001). Salbutamol significantly decreased Rrs (from 7.1 +/- 1.9 hPa.sec/L to 6.2 +/- 1.8 hPa sec/L, P < 0.0001) and increased Xrs (from -1.22 +/- 0.64 to -0.91 +/- 0.61 hPa.sec/L, P < 0.0001). Rrs response to salbutamol lower limit of 95% confidence interval was -38% from baseline Rrs and, Xrs upper limit was +16% from baseline impedance. It is concluded that reference values for respiratory impedance (Zrs) and thresholds for clinically relevant response to bronchodilator are provided in primary school Vietnamese children. A smaller slope for the observed Rrs-body height relationship is suggested with reference to relevant studies in healthy Caucasians.
Vu
Lan T T
LT
Khoa ho hap nhi Xanh pon, Department of Pediatric Pulmonology Saint Paul Hospital, Ha Noi, Viet Nam.
Demoulin
Bruno
B
Nguyen
Yen T
YT
Nguyen
Mai T H
MT
Marchal
François
F
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000420:Albuterol / Q000494:pharmacology*; D002648:Child; D017097:Electric Impedance; D005260:Female; D006801:Humans; D008297:Male; D012143:Respiratory Physiological Phenomena / Q000187:drug effects*; D012137:Respiratory System / Q000187:drug effects*; D014744:Vietnam
D000318:Adrenergic beta-Agonists; D000420:Albuterol