title: The Purkinje cell; 2008 style.
abstract: Cardiac Purkinje fibers, due to their unique anatomical location, cell structure and electrophysiologic characteristics, play an important role in cardiac conduction and arrhythmogenesis. Purkinje cell action potentials are longer than their ventricular counterpart, and display two levels of resting potential. Purkinje cells provide for rapid propagation of the cardiac impulse to ventricular cells and have pacemaker and triggered activity, which differs from ventricular cells. Additionally, a unique intracellular Ca2+ release coordination has been revealed recently for the normal Purkinje cell. However, since the isolation of single Purkinje cells is difficult, particularly in small animals, research using Purkinje cells has been restricted. This review concentrates on comparison of Purkinje and ventricular cells in the morphology of the action potential, ionic channel function and molecular determinants by summarizing our present day knowledge of Purkinje cells.
authors.affiliation: Department of Pharmacology, Center for Molecular Therapeutics, Columbia University, New York, NY, USA.
authors.forename: Wen
authors.initials: W
authors.lastname: Dun
authors.forename: Penelope A
authors.initials: PA
authors.lastname: Boyden
mesh_terms: D000200:Action Potentials; D000818:Animals; D002118:Calcium / Q000378:metabolism; D017630:Connexins / Q000378:metabolism; D005260:Female; D006352:Heart Ventricles / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D007477:Ions; D008297:Male; D008954:Models, Biological; D011188:Potassium / Q000378:metabolism; D020033:Protein Isoforms; D011689:Purkinje Cells / Q000166:cytology* / Q000378:metabolism; D012964:Sodium / Q000378:metabolism
chemical_list: D017630:Connexins; D007473:Ion Channels; D007477:Ions; D020033:Protein Isoforms; D012964:Sodium; D011188:Potassium; D002118:Calcium
references.citation: Circ Res. 1999 Jul 9;85(1):e1-6
references.pmid: 10400919
references.citation: Heart Rhythm. 2006 Dec;3(12):1469-80
references.pmid: 17161791
references.citation: Am J Physiol Heart Circ Physiol. 2000 Aug;279(2):H466-74
references.pmid: 10924043
references.citation: Am J Physiol. 1990 Mar;258(3 Pt 2):H766-72
references.pmid: 2156455
references.citation: J Physiol. 2007 Mar 1;579(Pt 2):465-71
references.pmid: 17218348
references.citation: Am J Physiol Heart Circ Physiol. 2002 Dec;283(6):H2495-503
references.pmid: 12388306
references.citation: Circ Res. 2003 Aug 8;93(3):189-91
references.pmid: 12842918
references.citation: J Physiol. 1968 Mar;195(1):185-214
references.pmid: 5639799
references.citation: Cardiovasc Res. 2005 Aug 15;67(3):529-38
references.pmid: 16039274
references.citation: Physiol Rev. 2001 Oct;81(4):1791-826
references.pmid: 11581502
references.citation: Exp Physiol. 2008 Mar;93(3):347-61
references.pmid: 17993508
references.citation: Circ Res. 1970 Jun;26(6):705-16
references.pmid: 4393106
references.citation: J Cell Sci. 1993 Aug;105 ( Pt 4):985-91
references.pmid: 8227219
references.citation: J Neurosci. 2005 Nov 2;25(44):10247-51
references.pmid: 16267232
references.citation: J Physiol. 2000 Apr 15;524 Pt 2:415-22
references.pmid: 10766922
references.citation: J Physiol. 2007 Jul 15;582(Pt 2):675-93
references.pmid: 17478540
references.citation: Pacing Clin Electrophysiol. 1996 Nov;19(11 Pt 2):2023-6
references.pmid: 8945090
references.citation: J Physiol. 1995 Jun 1;485 ( Pt 2):469-83
references.pmid: 7545232
references.citation: Cardiovasc Res. 2003 Mar;57(3):681-93
references.pmid: 12618230
references.citation: Circ Res. 2000 Mar 3;86(4):448-55
references.pmid: 10700450
references.citation: Circ Res. 2002 May 17;90(9):939-50
references.pmid: 12016259
references.citation: Pflugers Arch. 1982 Sep;394(3):230-8
references.pmid: 7145603
references.citation: Physiol Rev. 2004 Apr;84(2):431-88
references.pmid: 15044680
references.citation: J Membr Biol. 2007 Aug;218(1-3):13-28
references.pmid: 17661127
references.citation: Circ Res. 1993 Sep;73(3):482-91
references.pmid: 8394224
references.citation: Am J Physiol. 1997 Nov;273(5):H2481-9
references.pmid: 9374788
references.citation: Pflugers Arch. 1979 Mar 16;379(2):137-42
references.pmid: 571107
references.citation: Cardiovasc Res. 2005 Jan 1;65(1):117-27
references.pmid: 15621039
references.citation: J Physiol. 1998 May 1;508 ( Pt 3):811-23
references.pmid: 9518735
references.citation: Cardiovasc Res. 1983 Oct;17(10):608-19
references.pmid: 6627269
references.citation: J Physiol. 1981 May;314:359-76
references.pmid: 6273533
references.citation: Am J Physiol. 1989 May;256(5 Pt 2):H1478-92
references.pmid: 2470265
references.citation: J Physiol. 1982 Mar;324:507-33
references.pmid: 7097608
references.citation: Proc Biol Sci. 1992 Apr 22;248(1321):9-18
references.pmid: 1381835
references.citation: Circ Res. 2006 Jun 9;98(11):1422-30
references.pmid: 16690884
references.citation: Am J Physiol Heart Circ Physiol. 2005 May;288(5):H2123-30
references.pmid: 15615842
references.citation: Heart Rhythm. 2004 Jul;1(2):218-26
references.pmid: 15851156
references.citation: Physiol Rev. 2007 Apr;87(2):457-506
references.pmid: 17429038
references.citation: J Cardiovasc Electrophysiol. 2004 Jan;15(1):52-8
references.pmid: 15028072
references.citation: Cardiovasc Res. 1999 Nov;44(2):356-69
references.pmid: 10690312
references.citation: J Muscle Res Cell Motil. 2007;28(2-3):115-21
references.pmid: 17572852
references.citation: J Mol Cell Cardiol. 1984 Jan;16(1):33-42
references.pmid: 6699917
references.citation: Am J Physiol Heart Circ Physiol. 2001 Mar;280(3):H1075-80
references.pmid: 11179049
references.citation: Circ Res. 1990 Sep;67(3):615-27
references.pmid: 2397572
references.citation: Circulation. 2001 Oct 23;104(17):2095-100
references.pmid: 11673352
references.citation: Circulation. 2001 Mar 20;103(11):1591-8
references.pmid: 11257090
references.citation: Circulation. 1995 Aug 1;92(3):465-73
references.pmid: 7634462
references.citation: J Mol Cell Cardiol. 2007 Mar;42(3):469-77
references.pmid: 17289073
references.citation: J Physiol. 1996 May 1;492 ( Pt 3):789-806
references.pmid: 8734990
references.citation: Herz. 2003 Nov;28(7):598-606
references.pmid: 14689120
references.citation: Am J Physiol Heart Circ Physiol. 2000 Mar;278(3):H806-17
references.pmid: 10710349
references.citation: Br J Pharmacol. 2006 Mar;147(6):653-60
references.pmid: 16314855
references.citation: J Mol Cell Cardiol. 2005 Feb;38(2):277-87
references.pmid: 15698834
references.citation: J Mol Cell Cardiol. 2007 Feb;42(2):378-89
references.pmid: 17184792
references.citation: Circ Res. 2003 Feb 21;92(3):e45-50
references.pmid: 12595348
references.citation: Circ Res. 1989 Oct;65(4):955-70
references.pmid: 2791230
references.citation: Biophys J. 1987 Oct;52(4):519-25
references.pmid: 2445390
references.citation: J Gen Physiol. 1977 Dec;70(6):725-46
references.pmid: 591921
references.citation: J Mol Cell Cardiol. 2008 Aug;45(2):176-84
references.pmid: 18586264
references.citation: Am J Physiol. 1987 Nov;253(5 Pt 2):H1018-25
references.pmid: 3688246
references.citation: J Physiol. 1984 Apr;349:643-61
references.pmid: 6737305
references.citation: Circ Res. 2002 Nov 1;91(9):790-7
references.pmid: 12411393
references.citation: J Cardiovasc Pharmacol. 1987 Sep;10(3):332-40
references.pmid: 2444783
references.citation: Biophys J. 1984 Mar;45(3):509-12
references.pmid: 6324914
references.citation: Gen Pharmacol. 2000 Feb;34(2):85-93
references.pmid: 10974415
references.citation: Eur J Pharmacol. 2007 Mar 8;558(1-3):133-43
references.pmid: 17198698
references.citation: Circ Res. 2001 Aug 17;89(4):329-35
references.pmid: 11509449
references.citation: J Gen Physiol. 1995 Sep;106(3):559-78
references.pmid: 8786348
references.citation: Circ Res. 1978 Jul;43(1):29-35
references.pmid: 657457
references.citation: J Physiol. 1981;319:1-22
references.pmid: 7320907
references.citation: Heart Rhythm. 2005 Nov;2(11):1231-7
references.pmid: 16253914
references.citation: Circ Res. 1989 Dec;65(6):1735-50
references.pmid: 2555080
references.citation: Circulation. 2000 Jun 6;101(22):2639-44
references.pmid: 10840017
references.citation: J Pharmacol Exp Ther. 1989 Jul;250(1):397-405
references.pmid: 2746507
references.citation: J Physiol. 1988 Jan;395:233-53
references.pmid: 2457676
references.citation: Cardiovasc Res. 2004 Apr 1;62(1):9-33
references.pmid: 15023549
references.citation: J Physiol. 2000 Feb 15;523 Pt 1:67-81
references.pmid: 10675203
references.citation: J Cardiovasc Pharmacol. 2001 May;37(5):607-18
references.pmid: 11336111
references.citation: Nature. 2000 Feb 3;403(6769):553-6
references.pmid: 10676964
references.citation: Biochemistry. 1995 May 30;34(21):7252-7
references.pmid: 7766636
references.citation: J Gen Physiol. 1987 Nov;90(5):671-701
references.pmid: 3694174
references.citation: Cardiovasc Res. 2000 Jun;46(3):376-92
references.pmid: 10912449