Registration of 3-D CT and 2-D flat images of mouse via affine transformation.
It is difficult to directly coregister the 3-D fluorescence molecular tomography (FMT) image of a small tumor in a mouse whose maximal diameter is only a few millimeters with a larger CT image of the entire animal that spans about 10 cm. This paper proposes a new method to register 2-D flat and 3-D CT image first to facilitate the registration between small 3-D FMT images and large 3-D CT images. A novel algorithm combining differential evolution and improved simplex method for the registration between the 2-D flat and 3-D CT images is introduced and validated with simulated images and real images of mice. The visualization of the alignment of the 3-D FMT and CT image through 2-D registration shows promising results.
Xia
Zheng
Z
State Key Laboratory of Industrial Control Technology, Zhejiang University, Hangzhou 310027, China. zxia@iipc.zju.edu.cn
Huang
Xishi
X
Zhou
Xiaobo
X
Sun
Youxian
Y
Ntziachristos
Vasilis
V
Wong
Stephen T C
ST
D000465:Algorithms; D000818:Animals; D021621:Imaging, Three-Dimensional / Q000379:methods*; D051379:Mice; D008856:Microscopy, Fluorescence / Q000379:methods*; D013382:Subtraction Technique; D013899:Thoracic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D014057:Tomography, X-Ray Computed / Q000379:methods*