title: Association of CT60 polymorphism of the CTLA4 gene with Graves' disease in Taiwanese children.
abstract: BACKGROUND
  The CTLA4 gene is involved in the activity of T cells.
  
  
  OBJECTIVE
  To determine the association between Graves' disease (GD) susceptibility and CT60 polymorphism of the CTLA4 gene.
  
  
  METHODS
  189 children with GD and 620 healthy controls.
  
  
  METHODS
  We determined the genotype with restriction fragment length polymorphism and compared results.
  
  
  RESULTS
  Genotype G/G was significantly associated with GD (odds ratio [OR] = 1.71, 95% confidence interval [CI] 1.20-2.44, Pc = 0.006); however, allele A could reverse its effect. Allele G was significantly more frequent (OR = 1.61, 95% CI 1.18-2.19, Pc = 0.0049) but allele A (OR = 0.62, 95% CI 0.46-0.85, Pc = 0.0049) and phenotype A (OR = 0.58, 95% CI 0.41-0.83, Pc = 0.006) were less frequent in patients with GD than in controls.
  
  
  CONCLUSIONS
  The CT60 SNP was associated with susceptibility to GD. The G allele increased the risk of GD.
authors.affiliation: Department of Pediatrics, Taiwan Adventist Hospital, Taipei, Taiwan.
authors.forename: Suei-Tsau
authors.initials: ST
authors.lastname: Tsai
authors.forename: Chi-Yu
authors.initials: CY
authors.lastname: Huang
authors.forename: Fu-Sung
authors.initials: FS
authors.lastname: Lo
authors.forename: Ya-Ting
authors.initials: YT
authors.lastname: Chang
authors.forename: Takakuni
authors.initials: T
authors.lastname: Tanizawa
authors.forename: Chi-Kai
authors.initials: CK
authors.lastname: Chen
authors.forename: Zen-Chong
authors.initials: ZC
authors.lastname: Wang
authors.forename: Hsin-Fu
authors.initials: HF
authors.lastname: Liu
authors.forename: Chen-Chung
authors.initials: CC
authors.lastname: Chu
authors.forename: Marie
authors.initials: M
authors.lastname: Lin
authors.forename: Chao-Hsu
authors.initials: CH
authors.lastname: Lin
authors.forename: Hsin-Jung
authors.initials: HJ
authors.lastname: Li
authors.forename: Yann-Jinn
authors.initials: YJ
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000483:Alleles; D015703:Antigens, CD / Q000235:genetics*; D060908:CTLA-4 Antigen; D002648:Child; D002675:Child, Preschool; D004247:DNA / Q000096:biosynthesis / Q000235:genetics; D005260:Female; D005838:Genotype; D006111:Graves Disease / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D007223:Infant; D008297:Male; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013601:T-Lymphocytes / Q000378:metabolism; D013624:Taiwan / Q000453:epidemiology; D013960:Thyroid Function Tests; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood
chemical_list: D015703:Antigens, CD; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; D013972:Thyrotropin; D004247:DNA; D013974:Thyroxine