title: Effect of treatment with continuous positive airway pressure or oxygen on sleep-disordered breathing in patients with heart failure: results of the Sleep Events, Arrhythmias, and Respiratory Analysis in Chronic Heart Failure (SEARCH) study.
abstract: The response to sleep-disordered breathing (SDB)-directed therapy was evaluated using the Clear Path home-based monitoring system. There were 26 patients with heart failure enrolled in the Sleep Events, Arrhythmias, and Respiratory Analysis in Chronic Heart Failure (SEARCH) study with SDB requiring treatment (apnea-hypopnea index [AHI] >or=15 events/h). Patients were monitored using both standard polysomnography and the Clear Path system to determine the change in SDB parameters before and after initiation of therapy. Accuracy of the Clear Path system compared with polysomnography was >or=87% to detect SDB events. A marked reduction in the mean number of sleep time respiratory disturbances was observed by both techniques after the initiation of SDB-directed therapy, and 21 patients (87.5%) experienced a 16.7-events/h mean reduction in AHI. Thus, the Clear Path system appears to be a useful device to monitor response to SDB-directed treatment for apnea in patients with heart failure.
authors.affiliation: The Ohio State University Heart Center, Columbus, OH 43210, USA.
authors.forename: William T
authors.initials: WT
authors.lastname: Abraham
authors.forename: Robin J
authors.initials: RJ
authors.lastname: Trupp
authors.forename: Barbara
authors.initials: B
authors.lastname: Phillips
authors.forename: Robert C
authors.initials: RC
authors.lastname: Bourge
authors.forename: Susan M
authors.initials: SM
authors.lastname: Harding
authors.forename: Peter
authors.initials: P
authors.lastname: Schofield
authors.forename: Samantha
authors.initials: S
authors.lastname: Pilsworth
authors.forename: John M
authors.initials: JM
authors.lastname: Shneerson
authors.forename: Thomas
authors.initials: T
authors.lastname: Di Salvo
authors.forename: Janice
authors.initials: J
authors.lastname: Camuso
authors.forename: Douglas C
authors.initials: DC
authors.lastname: Johnson
authors.forename: Martin
authors.initials: M
authors.lastname: King
mesh_terms: D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D045422:Continuous Positive Airway Pressure; D005260:Female; D006333:Heart Failure / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010102:Oxygen Inhalation Therapy; D017286:Polysomnography; D011446:Prospective Studies; D012129:Respiratory Function Tests; D012137:Respiratory System / Q000503:physiopathology*; D012680:Sensitivity and Specificity; D020182:Sleep Apnea, Central / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome