Structure-based optimization of protein tyrosine phosphatase-1 B inhibitors: capturing interactions with arginine 24.
Wan
Zhao-Kui
ZK
Chemical and Screening Sciences, Wyeth Research, 200 Cambridgepark Drive, Cambridge, MA 02140, USA.
Lee
Jinbo
J
Hotchandani
Rajeev
R
Moretto
Alessandro
A
Binnun
Eva
E
Wilson
Douglas P
DP
Kirincich
Steve J
SJ
Follows
Bruce C
BC
Ipek
Manus
M
Xu
Weixin
W
Joseph-McCarthy
Diane
D
Zhang
Yan-Ling
YL
Tam
May
M
Erbe
David V
DV
Tobin
James F
JF
Li
Wei
W
Tam
Steve Y
SY
Mansour
Tarek S
TS
Wu
Junjun
J
D001120:Arginine / Q000737:chemistry*; D018360:Crystallography, X-Ray; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors* / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; D001120:Arginine; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1