title: Participation of caudal müllerian mesenchyma in prostate development.
abstract: OBJECTIVE
  The human prostate is a heterogeneous tissue. The cause remains unknown. This riddle has become a major problem to modern medicine because it hinders the understanding of human prostatic diseases. I examined the progress recently made in research on urogenital tract development and pathology.
  
  
  METHODS
  A comprehensive review of all relevant literature was performed.
  
  
  RESULTS
  During müllerian duct regression in males the epithelial cells undergo epithelial-mesenchymal transition and enter the mesenchymal compartment. The caudal müllerian mesenchyma participates in the development of the rodent and human prostate under the induction of androgen receptor. It retains responsiveness to estrogenic stimulation. Heterogeneous distributions of different mesenchymas cause heterogeneity. This confirms the hypothesis of Price of homologies between rodent and human prostates.
  
  
  CONCLUSIONS
  Like the gonad gland, the caudal müllerian duct has a sexual dimorphism of differentiation. It would develop into the vagina in females or the prostate in males, which is controlled by androgen receptor. The features of prostatic müllerian mesenchyma might shed light on the etiology of prostatic carcinogenesis.
authors.affiliation: Department of Physiology, University of Tennessee, Memphis, Tennessee 38103, USA. ycai@physio1.utmem.edu
authors.forename: Yi
authors.initials: Y
authors.lastname: Cai
mesh_terms: D000728:Androgens / Q000378:metabolism; D000818:Animals; D004967:Estrogens / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008648:Mesoderm / Q000196:embryology* / Q000378:metabolism; D009095:Mullerian Ducts / Q000196:embryology* / Q000378:metabolism; D038081:Organogenesis / Q000502:physiology*; D011467:Prostate / Q000196:embryology*; D012377:Rodentia; D012680:Sensitivity and Specificity; D012733:Sex Differentiation
chemical_list: D000728:Androgens; D004967:Estrogens