title: Computational prediction models for early detection of risk of cardiovascular events using mass spectrometry data.
abstract: Early prediction of the risk of cardiovascular events in patients with chest pain is critical in order to provide appropriate medical care for those with positive diagnosis. This paper introduces a computational methodology for predicting such events in the context of robust computerized classification using mass spectrometry data of blood samples collected from patients in emergency departments. We applied the computational theories of statistical and geostatistical linear prediction models to extract effective features of the mass spectra and a simple decision logic to classify disease and control samples for the purpose of early detection. While the statistical and geostatistical techniques provide better results than those obtained from some other methods, the geostatistical approach yields superior results in terms of sensitivity and specificity in various designs of the data set for validation, training, and testing. The proposed computational strategies are very promising for predicting major adverse cardiac events within six months.
authors.affiliation: School of Information Technology and Electrical Engineering, the University of New South Wales, ADFA, Canberra, ACT 2006, Australia. t.pham@adfa.edu.au
authors.forename: Tuan D
authors.initials: TD
authors.lastname: Pham
authors.forename: Honghui
authors.initials: H
authors.lastname: Wang
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Zhou
authors.forename: Dominik
authors.initials: D
authors.lastname: Beck
authors.forename: Miriam
authors.initials: M
authors.lastname: Brandl
authors.forename: Gerard
authors.initials: G
authors.lastname: Hoehn
authors.forename: Joseph
authors.initials: J
authors.lastname: Azok
authors.forename: Marie-Luise
authors.initials: ML
authors.lastname: Brennan
authors.forename: Stanley L
authors.initials: SL
authors.lastname: Hazen
authors.forename: King
authors.initials: K
authors.lastname: Li
authors.forename: Stephen T C
authors.initials: ST
authors.lastname: Wong
mesh_terms: D000465:Algorithms; D015415:Biomarkers / Q000097:blood; D001774:Blood Chemical Analysis / Q000379:methods; D001798:Blood Proteins / Q000032:analysis*; D002318:Cardiovascular Diseases / Q000097:blood* / Q000175:diagnosis*; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D001798:Blood Proteins