title: Striatal lesions interfere with acquisition of a complex maze task in rats.
abstract: The 14-unit T-maze has proven to be a valuable tool for investigating age-associated memory impairment (AAMI). While another task widely used to evaluate AAMI, the water maze, is primarily used to evaluate allocentric hippocampal-dependent spatial memory, the 14-unit T-maze can assess egocentric procedural memory. Although several brain structures, e.g. hippocampus, parietal cortex, have been implicated in acquisition and retention performance in the 14-unit T-maze, there has been no evaluation of the involvement of the striatum, a brain region implicated in procedural learning and memory. The current study revealed that excitotoxic lesions of the medial or lateral striatum significantly impaired acquisition, as measured by errors and latency, on this task without disruption of motor function. These results indicate that the 14-unit T-maze most likely is requires a large egocentric procedural learning component, and previously observed AAMI may involve age-related dysfunction of the striatum.
authors.affiliation: Behavioral Neuroscience Section, Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, Gerontology Research Center, 5600 Nathan Shock Dr., Baltimore, MD 21224, USA.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Pistell
authors.forename: Chris M
authors.initials: CM
authors.lastname: Nelson
authors.forename: Marshall G
authors.initials: MG
authors.lastname: Miller
authors.forename: Edward L
authors.initials: EL
authors.lastname: Spangler
authors.forename: Donald K
authors.initials: DK
authors.lastname: Ingram
authors.forename: Bryan D
authors.initials: BD
authors.lastname: Devan
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D017072:Neostriatum / Q000502:physiology*; D011340:Problem Solving / Q000502:physiology*; D051381:Rats; D011916:Rats, Inbred F344; D011930:Reaction Time / Q000502:physiology
references.citation: Hippocampus. 1999;9(5):553-61
references.pmid: 10560926
references.citation: J Neurosci. 1999 Apr 1;19(7):2789-98
references.pmid: 10087090
references.citation: Learn Mem. 2004 Jul-Aug;11(4):459-63
references.pmid: 15286184
references.citation: Acta Neurobiol Exp (Wars). 1972;32(2):479-94
references.pmid: 5075635
references.citation: Behav Brain Res. 1999 Apr;100(1-2):5-14
references.pmid: 10212049
references.citation: Neurobiol Aging. 2008 Nov;29(11):1680-9
references.pmid: 17524525
references.citation: Ann N Y Acad Sci. 1985;444:312-31
references.pmid: 3860091
references.citation: Trends Neurosci. 1992 Apr;15(4):133-9
references.pmid: 1374971
references.citation: Behav Brain Res. 1989 Dec 1;35(3):253-63
references.pmid: 2597342
references.citation: Curr Opin Neurobiol. 2007 Dec;17(6):692-7
references.pmid: 18313289
references.citation: Brain Res. 1977 Nov 25;137(1):53-66
references.pmid: 922507
references.citation: Behav Neurosci. 2000 Dec;114(6):1096-108
references.pmid: 11142642
references.citation: J Neurosci. 1998 Apr 15;18(8):3050-8
references.pmid: 9526022
references.citation: Ann N Y Acad Sci. 1998 Nov 20;854:307-17
references.pmid: 9928439
references.citation: AJNR Am J Neuroradiol. 2003 Oct;24(9):1849-56
references.pmid: 14561615
references.citation: Trends Neurosci. 2004 Aug;27(8):468-74
references.pmid: 15271494
references.citation: Int J Geriatr Psychiatry. 2002 Apr;17(4):359-70
references.pmid: 11994891
references.citation: J Neurosci. 1997 Nov 15;17(22):8919-26
references.pmid: 9348358
references.citation: Physiol Behav. 1993 Feb;53(2):221-8
references.pmid: 8446684
references.citation: J Comp Neurol. 1982 Mar 10;205(4):398-413
references.pmid: 7096628
references.citation: Psychopharmacology (Berl). 2006 Jan;183(4):439-45
references.pmid: 16320087
references.citation: Exp Brain Res. 1993;93(3):462-70
references.pmid: 8519335
references.citation: Microsc Res Tech. 1998 Oct 1;43(1):68-74
references.pmid: 9829461
references.citation: Brain Res. 1990 Dec 17;536(1-2):245-50
references.pmid: 1707719
references.citation: Neurobiol Learn Mem. 1996 Jan;65(1):65-72
references.pmid: 8673408
references.citation: Behav Brain Res. 1987 May;24(2):125-38
references.pmid: 3593524
references.citation: Behav Neural Biol. 1988 May;49(3):332-43
references.pmid: 3408445
references.citation: Neurobiol Learn Mem. 1996 Nov;66(3):305-23
references.pmid: 8946424
references.citation: Pharmacol Biochem Behav. 1986 Sep;25(3):673-9
references.pmid: 3022309
references.citation: Physiol Behav. 1990 Jan;47(1):207-12
references.pmid: 2326338
references.citation: Nat Rev Neurosci. 2006 Jun;7(6):464-76
references.pmid: 16715055
references.citation: Exp Gerontol. 1997 Nov-Dec;32(6):707-17
references.pmid: 9785096
references.citation: Behav Neurosci. 1995 Aug;109(4):579-93
references.pmid: 7576202
references.citation: Behav Brain Res. 1991 Nov 26;45(2):147-61
references.pmid: 1789923
references.citation: Behav Neural Biol. 1994 May;61(3):260-70
references.pmid: 8067981
references.citation: J Comp Physiol Psychol. 1969 Dec;69(4):756-64
references.pmid: 5359150
references.citation: Pharmacol Biochem Behav. 2004 Dec;79(4):691-9
references.pmid: 15582676
references.citation: Behav Neurosci. 1992 Jun;106(3):439-46
references.pmid: 1616610
references.citation: Ann N Y Acad Sci. 1996 Jun 15;786:348-61
references.pmid: 8687034
references.citation: Brain Res. 1976 May 21;108(1):37-46
references.pmid: 1276891
references.citation: Neurobiol Aging. 1990 Mar-Apr;11(2):155-8
references.pmid: 2161505
references.citation: J Neurosci. 1999 Jun 1;19(11):4585-94
references.pmid: 10341256