title: Angiotensin-converting enzyme D allele does not influence susceptibility to acute hypoxic respiratory failure in children.
abstract: OBJECTIVE
  The D allele of the I/D polymorphism in the angiotensin-converting enzyme (ACE) gene has been associated with an increased risk of ARDS in critically ill adults and severity of bronchopulmonary dysplasia in pre-term infants. We hypothesised that the presence of the hypoxia-associated ACE D allele would increase susceptibility to acute hypoxic respiratory failure (AHRF) in a cohort of critically ill children.
  
  
  METHODS
  Single-centre prospective observational cohort study.
  
  
  METHODS
  Children under 16 years of age requiring admission to a tertiary general PICU.
  
  
  RESULTS
  A total of 216 Caucasian patients were enrolled. Thirty (13.9%) children developed AHRF and 13 were diagnosed with ARDS (6.0%). There was no significant difference in ACE D allele frequency between patient groups with or without AHRF (0.53 vs. 0.54).
  
  
  CONCLUSIONS
  Variation in ACE activity does not influence the development of paediatric AHRF. This may reflect a different pathogenesis from adult ARDS.
authors.affiliation: Paediatric Intensive Care Unit, Great Ormond Street Hospital for Children NHS Trust, London, UK.
authors.forename: Adrian
authors.initials: A
authors.lastname: Plunkett
authors.forename: Rachel S
authors.initials: RS
authors.lastname: Agbeko
authors.forename: Kawah
authors.initials: K
authors.lastname: Li
authors.forename: Steve E
authors.initials: SE
authors.lastname: Humphries
authors.forename: Nigel J
authors.initials: NJ
authors.lastname: Klein
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Peters
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004198:Disease Susceptibility; D005787:Gene Frequency / Q000235:genetics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007362:Intensive Care Units; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012128:Respiratory Distress Syndrome / Q000235:genetics; D012131:Respiratory Insufficiency / Q000235:genetics*
chemical_list: D007703:Peptidyl-Dipeptidase A
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