Natural products as inspiration for the development of asymmetric catalysis.
Biologically active natural products often contain particularly challenging structural features and functionalities in terms of synthesis. Perhaps the greatest difficulties are those caused by issues of stereochemistry. A useful strategy for synthesizing such molecules is to devise methods of bond formation that provide opportunities for using enantioselective catalysis. In using this tactic, the desire for a particular target structure ultimately drives the development of catalytic methods. New enantioselective catalytic methods contribute to a greater fundamental understanding of how bonds can be constructed and lead to valuable synthetic technologies that are useful for a variety of applications.
Mohr
Justin T
JT
The Arnold and Mabel Beckman Laboratories of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, MC 164-30, Pasadena, California 91125, USA.
Krout
Michael R
MR
Stoltz
Brian M
BM
D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry*; D002227:Carbazoles / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D004224:Diterpenes / Q000138:chemical synthesis / Q000737:chemistry; D007189:Indans / Q000138:chemical synthesis / Q000737:chemistry; D026121:Indole Alkaloids / Q000138:chemical synthesis / Q000737:chemistry; D007212:Indolizines / Q000138:chemical synthesis / Q000737:chemistry; D007769:Lactams / Q000138:chemical synthesis / Q000737:chemistry; D011719:Pyrazines / Q000138:chemical synthesis / Q000737:chemistry; D000068900:Sitagliptin Phosphate; D013141:Spiro Compounds / Q000138:chemical synthesis / Q000737:chemistry; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry
D001688:Biological Products; D002227:Carbazoles; D004224:Diterpenes; D007189:Indans; D026121:Indole Alkaloids; D007212:Indolizines; D007769:Lactams; D011719:Pyrazines; D013141:Spiro Compounds; D014230:Triazoles; C530546:cyanthiwigin F; C526622:fluvirucinine A1; C504098:minfiensine; C041254:flustramine B; C013352:indacrinone; D000068900:Sitagliptin Phosphate; C518918:marcfortine B
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