Biologically active 2-5A analogs containing 3'-O,4'-C-propylene adenosine as potent RNase L agonists.
Novel 2-5A analogs composed of 3'-O, 4'-C-alkylene adenosine were synthesized as potent RNase L activators. When we examined their properties, including their RNase L activating ability and their stability to exonuclease, we found that these 2-5A analogs showed high RNase L activation and high resistance to enzymatic degradation without the modification of an essential adenosine at the second position.
Morita
Koji
K
Formulation Technology Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo 140-8710, Japan.
Obika
Satoshi
S
Imanishi
Takeshi
T
Kitade
Yukio
Y
Koizumi
Makoto
M
D000227:Adenine Nucleotides / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D004722:Endoribonucleases / Q000378:metabolism*; D004789:Enzyme Activation; D009843:Oligoribonucleotides / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology
D000227:Adenine Nucleotides; D000970:Antineoplastic Agents; D009843:Oligoribonucleotides; C023505:2',5'-oligoadenylate; D004722:Endoribonucleases; C031956:2-5A-dependent ribonuclease