Oscillatory bands, neuronal synchrony and hippocampal function: implications of the effects of prenatal choline supplementation for sleep-dependent memory consolidation.
Choline supplementation of the maternal diet has long-term facilitative effects on spatial and temporal memory processes in the offspring. To further delineate the impact of early nutritional status on brain and behavior, we examined effects of prenatal-choline availability on hippocampal oscillatory frequency bands in 12 month-old male and female rats. Adult offspring of time-pregnant dams that were given a deficient level of choline (DEF=0.0 g/kg), sufficient choline (CON=1.1 g/kg) or supplemental choline (SUP=3.5 g/kg) in their chow during embryonic days (ED) 12-17 were implanted with an electroencephalograph (EEG) electrode in the hippocampal dentate gyrus in combination with an electromyograph (EMG) electrode patch implanted in the nuchal muscle. Five consecutive 8-h recording sessions revealed differential patterns of EEG activity as a function of awake, slow-wave sleep (SWS) and rapid-eye movement (REM) sleep states and prenatal choline status. The main finding was that SUP rats displayed increased power levels of gamma (30-100 Hz) band oscillations during all phases of the sleep/wake cycle. These findings are discussed within the context of a general review of neuronal oscillations (e.g., delta, theta, and gamma bands) and synchronization across multiple brain regions in relation to sleep-dependent memory consolidation in the hippocampus.
Cheng
Ruey-Kuang
RK
Department of Psychology and Neuroscience,572 Research Drive, Duke University, Durham, NC 27708, USA.
Williams
Christina L
CL
Meck
Warren H
WH
D000465:Algorithms; D000818:Animals; D001683:Biological Clocks / Q000187:drug effects / Q000502:physiology; D002794:Choline / Q000008:administration & dosage*; D019587:Dietary Supplements; D004569:Electroencephalography / Q000379:methods; D004576:Electromyography; D005260:Female; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D018697:Nootropic Agents / Q000008:administration & dosage*; D011247:Pregnancy; D039401:Prenatal Nutritional Physiological Phenomena; D051381:Rats; D012890:Sleep / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
D018697:Nootropic Agents; D002794:Choline