title: Influence of phosphorohydrazone derivatives of benzopyrones on polymerization and viscosity of fibrin.
abstract: The synthesis and antitumour and antibacterial activity of coumarin and chromone phosphorohydrazones have been reported. This study describes influence of phosphorohydrazones derivatives of coumarin and chromone on the polymerization and viscosity of fibrin. The fibrin polymerization assay was performed by the Shen and Lorand method and the clot viscosity was measured on the basis of Shen and Lorand and Marchi and coworkers methods. Among the eight compounds tested, one coumarin derivative and two chromone derivatives showed significant activity.
authors.affiliation: Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Medical University of Łódź, Łódź, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Michalska
authors.forename: Wojciech
authors.initials: W
authors.lastname: Pajak
authors.forename: Justyna
authors.initials: J
authors.lastname: Kołodziejska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Lazarenkow
authors.forename: Jolanta
authors.initials: J
authors.lastname: Nawrot-Modranka
mesh_terms: D001704:Biopolymers / Q000737:chemistry; D002867:Chromones / Q000737:chemistry / Q000494:pharmacology*; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology*; D005337:Fibrin / Q000737:chemistry* / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D015394:Molecular Structure; D013056:Spectrophotometry, Ultraviolet; D014783:Viscosity / Q000187:drug effects
chemical_list: D001704:Biopolymers; D002867:Chromones; D003374:Coumarins; D005337:Fibrin