title: Spontaneous prenatal ductal closure: postnatal diagnosis?
abstract: Prenatal ductal constriction and closure usually are related to maternal intake of prostaglandin receptor inhibitors during late gestation but may occur spontaneously. This report describes three live-born infants sharing echocardiographic features of spontaneous intrauterine ductal constriction, closure, or both, although only one had a prenatal diagnosis. Interestingly, in addition to severely hypertrophied right ventricles, all three had hyperechogenic tricuspid valve papillary muscles. Two also had mild ascending aorta dilation. These cases raise mechanistic questions because of intrauterine ductal occlusion, bright papillary muscles, and potential dilated ascending aortas.
authors.affiliation: Department of Cardiology, Skejby University Hospital, Aarhus, Denmark. siyg@uus.no
authors.forename: Sissel Irene
authors.initials: SI
authors.lastname: Nygaard
authors.forename: Olav Bjorn
authors.initials: OB
authors.lastname: Petersen
authors.forename: Ester
authors.initials: E
authors.lastname: Garne
authors.forename: Keld Ejvind
authors.initials: KE
authors.lastname: Sørensen
mesh_terms: D001011:Aorta / Q000002:abnormalities / Q000000981:diagnostic imaging; D001018:Aortic Diseases / Q000000981:diagnostic imaging / Q000473:pathology; D004374:Ductus Arteriosus, Patent / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D017380:Hypertrophy, Right Ventricular / Q000000981:diagnostic imaging* / Q000473:pathology; D007231:Infant, Newborn; D008297:Male; D010210:Papillary Muscles / Q000002:abnormalities* / Q000000981:diagnostic imaging; D014261:Tricuspid Valve / Q000002:abnormalities* / Q000000981:diagnostic imaging; D016216:Ultrasonography, Prenatal
references.citation: Am J Obstet Gynecol. 1997 Aug;177(2):256-9; discussion 259-61
references.pmid: 9290437
references.citation: J Clin Invest. 2006 Nov;116(11):3026-34
references.pmid: 17080198
references.citation: Cardiol Young. 2005 Aug;15(4):434-6
references.pmid: 16014196
references.citation: Circulation. 1979 Aug;60(2):360-4
references.pmid: 445754
references.citation: Z Geburtshilfe Neonatol. 2005 Apr;209(2):65-8
references.pmid: 15852232
references.citation: N Engl J Med. 1988 Aug 11;319(6):327-31
references.pmid: 3393194
references.citation: Cardiol Young. 2004 Aug;14(4):450-2
references.pmid: 15680055
references.citation: Am J Obstet Gynecol. 1996 Mar;174(3):879-83
references.pmid: 8633660
references.citation: Prenat Diagn. 2000 Apr;20(4):287-92
references.pmid: 10740200
references.citation: Fetal Pediatr Pathol. 2006 May-Jun;25(3):151-7
references.pmid: 17060191
references.citation: Pathol Int. 2006 Sep;56(9):554-7
references.pmid: 16930337
references.citation: Ann Pharmacother. 2006 May;40(5):824-9
references.pmid: 16638921
references.citation: Ultrasound Obstet Gynecol. 2005 Apr;25(4):357-61
references.pmid: 15791693
references.citation: Am J Physiol Regul Integr Comp Physiol. 2006 Dec;291(6):R1717-1723
references.pmid: 16857891
references.citation: Ann Thorac Surg. 2007 Feb;83(2):680-2
references.pmid: 17258015