Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells.
Little is known about the functional differences between the human skin myeloid dendritic cell (DC) subsets, epidermal CD207(+) Langerhans cells (LCs) and dermal CD14(+) DCs. We showed that CD14(+) DCs primed CD4(+) T cells into cells that induce naive B cells to switch isotype and become plasma cells. In contrast, LCs preferentially induced the differentiation of CD4(+) T cells secreting T helper 2 (Th2) cell cytokines and were efficient at priming and crosspriming naive CD8(+) T cells. A third DC population, CD14(-)CD207(-)CD1a(+) DC, which resides in the dermis, could activate CD8(+) T cells better than CD14(+) DCs but less efficiently than LCs. Thus, the human skin displays three DC subsets, two of which, i.e., CD14(+) DCs and LCs, display functional specializations, the preferential activation of humoral and cellular immunity, respectively.
Klechevsky
Eynav
E
Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX 75204, USA.
Morita
Rimpei
R
Liu
Maochang
M
Cao
Yanying
Y
Coquery
Sebastien
S
Thompson-Snipes
Luann
L
Briere
Francine
F
Chaussabel
Damien
D
Zurawski
Gerard
G
Palucka
A Karolina
AK
Reiter
Yoram
Y
Banchereau
Jacques
J
Ueno
Hideki
H
D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D016207:Cytokines / Q000276:immunology / Q000378:metabolism*; D004817:Epidermis / Q000276:immunology; D053804:Granzymes / Q000378:metabolism; D006801:Humans; D007156:Immunologic Memory; D007801:Langerhans Cells / Q000276:immunology* / Q000378:metabolism; D018950:Lipopolysaccharide Receptors / Q000276:immunology; D008213:Lymphocyte Activation; D012867:Skin / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D016207:Cytokines; D018950:Lipopolysaccharide Receptors; D053804:Granzymes
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