title: Genetic variation in sodium-dependent vitamin C transporters SLC23A1 and SLC23A2 and risk of advanced colorectal adenoma.
abstract: Previous observational studies suggest that vitamin C may reduce risk of colorectal cancer. Vitamin C transport is facilitated by membrane bound sodium-dependent transporters, SVCT1 (encoded by SLC23A1) and SVCT2 (encoded by SLC23A2). To investigate if common genetic variants in these two genes are associated with risk of colorectal tumor development, we conducted a case-control study of 656 Caucasian advanced distal colorectal adenoma cases and 665 Caucasian sigmoidoscopy-negative controls nested within the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. The analysis of common single nucleotide polymorphisms in SLC23A1 revealed no association. For SLC23A2, overall, there was no association with haplotypes, but two SNPs located in intron 8 and exon 11 could be associated (odds ratio = 0.49, 95% confidence interval = 0.25-0.95 for haplotype G-C vs. haplotype C-C). The findings should be confirmed in follow-up studies, and further investigation is required to probe the functional basis of this finding.
authors.affiliation: Section on Genomic Variation, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-4605, USA.
authors.forename: Hans Christian
authors.initials: HC
authors.lastname: Erichsen
authors.forename: Ulrike
authors.initials: U
authors.lastname: Peters
authors.forename: Peter
authors.initials: P
authors.lastname: Eck
authors.forename: Robert
authors.initials: R
authors.lastname: Welch
authors.forename: Robert E
authors.initials: RE
authors.lastname: Schoen
authors.forename: Meredith
authors.initials: M
authors.lastname: Yeager
authors.forename: Mark
authors.initials: M
authors.lastname: Levine
authors.forename: Richard B
authors.initials: RB
authors.lastname: Hayes
authors.forename: Stephen
authors.initials: S
authors.lastname: Chanock
mesh_terms: D000236:Adenoma / Q000235:genetics*; D000368:Aged; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D029363:Organic Anion Transporters, Sodium-Dependent / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D060347:Sodium-Coupled Vitamin C Transporters; D011795:Surveys and Questionnaires; D027981:Symporters / Q000235:genetics*; D014481:United States
chemical_list: D029363:Organic Anion Transporters, Sodium-Dependent; C555162:SLC23A1 protein, human; C555163:SLC23A2 protein, human; D060347:Sodium-Coupled Vitamin C Transporters; D027981:Symporters
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