[Measures against hyperuricemia].
It is suggested that hyperuricemia has a pathogenetical role in the onset and progression of hypertension and renal disease in both clinical studies and animal experiments. The treatment of hyperuricemia by allopurinol was reported to cause improvement of hypertension and renal function, and the withdrawal of allopurinol treatment was also reported to bring worsening of hypertension and acceleration of the rate of loss of renal function in the patients with chronic kidney disease (CKD). However, the necessity of treatment against hyperuricemia in CKD has to be warranted by large scale clinical experiments in the future.
Ohno
Iwao
I
Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine.
Hosoya
Tatsuo
T
D000493:Allopurinol / Q000627:therapeutic use; D000818:Animals; D002908:Chronic Disease; D018450:Disease Progression; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology; D033461:Hyperuricemia / Q000150:complications* / Q000188:drug therapy*; D007674:Kidney Diseases / Q000209:etiology* / Q000517:prevention & control; D024821:Metabolic Syndrome / Q000150:complications; D012307:Risk Factors
D000493:Allopurinol