Significant correlation between surgical stress of hepatectomy and changes in the serum levels of HGF, IL-6 and soluble Fas in patients with viral hepatitis.
OBJECTIVE
Liver damage after hepatectomy is still a serious concern. The present study was designed to clarify the relations between liver injury/surgical stress and cytokines after hepatectomy, in patients with viral hepatitis.


METHODS
Ten consecutive patients undergoing hepatectomy were studied, all with hepatocellular carcinoma due to viral hepatitis. Blood samples for interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), hepatocyte growth factor (HGF), soluble Fas (sFas), soluble Fas Ligand and soluble tumor necrosis factor receptor (sTNFR) assays were collected before the operation and at the end of the operation.


RESULTS
There was a significant and positive correlation between the change in the serum level of HGF and preoperative liver function (ICG-R15). Notably, there were significant correlations between surgical stress and IL-6, HGF and sFas, but not sIL-6R and sTNFR. Furthermore, there was significant correlation between postoperative liver function (total bilirubin, albumin) and HGF, IL-6.


CONCLUSIONS
There was a close relationship between surgical stress and HGF, IL-6 and sFas after hepatectomy in patients with viral hepatitis. It was useful for the evaluation of surgical stress of hepatectomy to estimate the serum level of HGF, IL-6 and sFas.
Gotohda
Naoto
N
Department of Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha Kashiwa, 277-8577 Chiba, Japan. ngotohda@east.ncc.go.jp
Iwagaki
Hiromi
H
Ozaki
Michitaka
M
Kinoshita
Taira
T
Konishi
Masaru
M
Nakagohri
Toshio
T
Takahashi
Shinichiro
S
Saito
Shinya
S
Yagi
Takahito
T
Tanaka
Noriaki
N
D000368:Aged; D015331:Cohort Studies; D005260:Female; D006498:Hepatectomy / Q000009:adverse effects*; D019694:Hepatitis B, Chronic / Q000097:blood* / Q000473:pathology / Q000601:surgery; D019698:Hepatitis C, Chronic / Q000097:blood* / Q000473:pathology / Q000601:surgery; D017228:Hepatocyte Growth Factor / Q000097:blood*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018121:Receptors, Cytokine / Q000097:blood; D013312:Stress, Physiological / Q000502:physiology*; D016896:Treatment Outcome; D019014:fas Receptor / Q000097:blood*
C066855:HGF protein, human; D015850:Interleukin-6; D018121:Receptors, Cytokine; D019014:fas Receptor; D017228:Hepatocyte Growth Factor