Two novel triterpenoids with antiproliferative and apoptotic activities in human leukemia cells isolated from the resin of Garcinia hanburyi.
Two new triterpenoids, 2alpha-hydroxy-3beta-O-acetyllup-20(29)-en-28-oic acid (1) and 3- O-(4'- O-acetyl)-alpha- L-arabinopyranosyloleanolic acid ( 2), together with two known triterpenoids, betulinic acid ( 3) and messagenic acid ( 4) were isolated from the CHCl3 extract of Garcinia hanburyi resin. The structures were elucidated by analysis of the NMR spectroscopic data. The antiproliferative effects and the apoptosis induction abilities of compounds 1 and 2 were determined in four human leukemia cell lines. Compound 2 was more potent than compound 1 in inhibiting cell growth with IC50 values of 2.45, 2.69, 2.42, and 4.15 microM in HL-60, NB4, U937 and K562 cells, respectively.
Wang
Li-li
LL
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, P. R. China.
Li
Zhan-lin
ZL
Song
Dan-dan
DD
Sun
Lin
L
Pei
Yue-hu
YH
Jing
Yong-kui
YK
Hua
Hui-ming
HM
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D029760:Garcinia / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D007938:Leukemia; D015394:Molecular Structure; D012116:Resins, Plant / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D012116:Resins, Plant; D014315:Triterpenes