Molecular biology of pancreatic cancer.
Pancreatic cancer is a leading cause of cancer death. This devastating disease has the horrible honour of close to equal incidence and mortality rates. Late diagnosis and a constitutive resistance to every chemotherapy approach are responsible for this scenario. However, molecular biology tools in cooperation with translational efforts have dissected several secrets that underlie pancreatic cancer. Progressive acquisition of malignant, invasive phenotypes from pre-malignant lesions, recent revelations on core signalling pathways and new targeted designed trials offer a better future for pancreatic cancer patients. This review will summarise recent advances in the molecular biology of pancreatic cancer.
Belda-Iniesta
Cristóbal
C
Translational Oncology Unit CSIC/JAM at Medical Oncology Division, University Hospital La Paz, Universidad Autónoma de Madrid, Madrid, Spain.
Ibáñez de Cáceres
Immaculada
I
Barriuso
Jorge
J
de Castro Carpeño
Javier
J
González Barón
Manuel
M
Feliú
Jaime
J
D020022:Genetic Predisposition to Disease; D006801:Humans; D008967:Molecular Biology; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy
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