Post-transplant adoptive T-cell immunotherapy.
Immune reconstitution following haematopoietic stem cell transplantation (SCT) is an often slow and incomplete process that leads to increased risk of infection and malignant disease. Immunization in SCT is frequently unsuccessful due to the prolonged lymphopenia, especially of CD4 T cells, seen following transplant. The transfusion of T cells, also called 'adoptive T-cell therapy', has the potential to enhance anti-tumour and overall immunity, and augment vaccine efficacy in the post-transplant setting. Recent advances in tissue culture, cellular immunology and tumour biology are guiding new approaches to adoptive T-cell therapy. This chapter will discuss the challenges that face the field before adoptive T-cell therapy can be translated into routine clinical practice.
Aqui
Nicole A
NA
Abramson Family Cancer Research Institute and the Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104-1416, USA. aqui@mail.med.upenn.edu
June
Carl H
CH
D019264:Adoptive Transfer / Q000379:methods; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000637:transplantation; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000637:transplantation; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000209:etiology; D016219:Immunotherapy, Adoptive / Q000009:adverse effects; D008212:Lymphocyte Depletion; D033581:Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation*; D014184:Transplantation, Homologous
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