title: A case of oncocytic carcinoma of the endometrium.
abstract: We report an unusual case of endometrial adenocarcinoma in a 80-year-old woman who underwent mastectomy for breast cancer at 68 years of age. The tumor diffusely involved the entire thickness of the myometrium. Atypical cells throughout the tumor contained abundant oxiphilic cytoplasm and were arranged in a solid or solid-tubular nests in a focal papillary manner. Components of the carcinoma were focally observed in situ. The tumor was classified according to the International Federation of Gynecology and Obstetrics (FIGO) as grade 2 and stage IIIa. Immunohistochemistry revealed that the tumor cells were positive for p53 but negative for vimentin, estrogen, and progesterone receptors, GCDFP-15, and mammaglobin. They were positive for antimitochondrial antigen and thyroid transcription factor-1. The Ki-67 labeling index was approximately 50%. Immunostaining revealed endometrial oncocytic carcinoma. Distinguishing between primary uterine neoplasm and carcinoma caused by metastasis of breast cancer appears important.
authors.affiliation: Department of Pathology, Tokai University School of Medicine, Isehara, Kanagawa, Japan. h-kaji@is.icc.u-tokai.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kajiwara
authors.forename: Nobue
authors.initials: N
authors.lastname: Kumaki
authors.forename: Kenichi
authors.initials: K
authors.lastname: Hirabayashi
authors.forename: Masaki
authors.initials: M
authors.lastname: Miyazawa
authors.forename: Naoya
authors.initials: N
authors.lastname: Nakamura
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hirasawa
authors.forename: Toshinari
authors.initials: T
authors.lastname: Muramatsu
authors.forename: Mikio
authors.initials: M
authors.lastname: Mikami
authors.forename: Masanori
authors.initials: M
authors.lastname: Yasuda
authors.forename: R Y
authors.initials: RY
authors.lastname: Osamura
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D016190:Carboplatin / Q000008:administration & dosage; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D016889:Endometrial Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007150:Immunohistochemistry; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000473:pathology*; D017239:Paclitaxel / Q000008:administration & dosage
chemical_list: D016190:Carboplatin; D017239:Paclitaxel