title: Novel developments for improved detection of specific mRNAs by DNA chips.
abstract: Microarrays have revolutionized gene expression analysis as they allow for highly parallel monitoring of mRNA levels of thousands of genes in a single experiment. Since their introduction some 15 years ago, substantial progress has been achieved with regard to, e.g., faster or more sensitive analyses. In this review, interesting new approaches for a more sensitive detection of specific mRNAs will be highlighted. Particularly, the potential of electrical DNA chip formats that allow for faster mRNA analyses will be discussed.
authors.affiliation: Pharmazeutische Biotechnologie, Institut für Pharmazie, Ernst-Moritz-Arndt-Universität, Greifswald, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Pioch
authors.forename: Thomas
authors.initials: T
authors.lastname: Schweder
authors.forename: Britta
authors.initials: B
authors.lastname: Jürgen
mesh_terms: D004560:Electricity; D020869:Gene Expression Profiling / Q000379:methods*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D012333:RNA, Messenger / Q000032:analysis* / Q000235:genetics; D012680:Sensitivity and Specificity
chemical_list: D012333:RNA, Messenger