The multiple roles of phosphoinositide 3-kinase in mast cell biology.
Mast cells play a central role in the initiation of inflammatory responses associated with asthma and other allergic disorders. Receptor-mediated mast cell growth, differentiation, homing to their target tissues, survival and activation are all controlled, to varying degrees, by phosphoinositide-3-kinase (PI3K)-driven pathways. It is not fully understood how such diverse responses can be differentially regulated by PI3K. However, recent studies have provided greater insight into the mechanisms that control, and those that are controlled by, different PI3K subunit isoforms in mast cells. In this review, we discuss how PI3K influences the mast cell processes described above. Furthermore, we describe how different mast cell receptors use alternative isoforms of PI3K for these functions and discuss potential downstream targets of these isoforms.
Kim
Mi-Sun
MS
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Rådinger
Madeleine
M
Gilfillan
Alasdair M
AM
D019870:1-Phosphatidylinositol 4-Kinase / Q000276:immunology / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000276:immunology / Q000378:metabolism; D015550:Cell Degranulation / Q000276:immunology; D016207:Cytokines / Q000276:immunology* / Q000378:metabolism; D051858:Forkhead Transcription Factors / Q000276:immunology / Q000378:metabolism; D006801:Humans; D008407:Mast Cells / Q000201:enzymology / Q000276:immunology*; D051059:PTEN Phosphohydrolase / Q000276:immunology / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000276:immunology / Q000378:metabolism; D020033:Protein Isoforms / Q000276:immunology / Q000378:metabolism; D011494:Protein Kinases / Q000276:immunology / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000276:immunology / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000276:immunology / Q000378:metabolism; D019009:Proto-Oncogene Proteins c-kit / Q000276:immunology / Q000378:metabolism; D017455:Receptors, IgE / Q000276:immunology / Q000378:metabolism; D058570:TOR Serine-Threonine Kinases
D016207:Cytokines; D051858:Forkhead Transcription Factors; D020033:Protein Isoforms; D017455:Receptors, IgE; D011494:Protein Kinases; C546842:MTOR protein, human; D019870:1-Phosphatidylinositol 4-Kinase; D019009:Proto-Oncogene Proteins c-kit; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt; D058570:TOR Serine-Threonine Kinases; D010744:Phosphoric Monoester Hydrolases; D051059:PTEN Phosphohydrolase; D002118:Calcium
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