title: Intramolecular arylcyanation of alkenes catalyzed by nickel/AlMe2Cl.
abstract: A catalyst system derived from nickel and cocatalytic AlMe2Cl effects the intramolecular arylcyanation of alkenes. The reaction takes place in an exclusive exo-dig manner to give a wide range of nitriles having a benzylic quaternary carbon in good yields. Detailed investigations are described on the scope and mechanism as well as preliminary results on the asymmetric version of the reaction to provide novel access to chiral quaternary stereocenters.
authors.affiliation: Department of Material Chemistry, Kyoto University, Kyoto, Japan. yoshiakinakao@npc05.mbox.media.kyoto-u.ac.jp
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Nakao
authors.forename: Shiro
authors.initials: S
authors.lastname: Ebata
authors.forename: Akira
authors.initials: A
authors.lastname: Yada
authors.forename: Tamejiro
authors.initials: T
authors.lastname: Hiyama
authors.forename: Masashi
authors.initials: M
authors.lastname: Ikawa
authors.forename: Sensuke
authors.initials: S
authors.lastname: Ogoshi