title: Remineralization of deep enamel dentine caries lesions.
abstract: Enamel remineralization is generally studied in superficial (up to 100 mum) lesions, but in vivo caries lesions may be tenfold deeper. This article addresses the question whether deep lesions, and extending into dentine, can be remineralized under optimal conditions and if this process is influenced by agents affecting calcium phosphate precipitation and dissolution. Lesions through enamel into dentine were first formed in thin sections and then continuously remineralized for periods up to 200 days. With longitudinal assessment by transversal microradiography it was showed that remineralization throughout the depth of the lesion and into the dentine was possible, although this process is very slow. Fluoride and bisphosphonate treatments affected mainly the deposition in the outer enamel. Although it was assumed that this would affect the diffusion of ions to deeper layers, the treatments had no impact on remineralization in the inner enamel or dentinal parts of the lesions. These findings are discussed with relevant theoretical considerations, and in their possible clinical implications.
authors.affiliation: Department of Cariology Endodontology Pedodontology, Academic Center for Dentistry Amsterdam , Amsterdam, The Netherlands. j.t.cate@acta.nl
authors.forename: J M
authors.initials: JM
authors.lastname: ten Cate
mesh_terms: D002118:Calcium / Q000627:therapeutic use; D002130:Calcium Phosphates / Q000378:metabolism; D002327:Cariostatic Agents / Q000627:therapeutic use*; D011232:Chemical Precipitation; D003198:Computer Simulation; D003460:Crystallization; D003731:Dental Caries / Q000188:drug therapy*; D003804:Dentin / Q000473:pathology*; D003806:Dentin Permeability; D004058:Diffusion; D004164:Diphosphonates / Q000627:therapeutic use; D005459:Fluorides / Q000627:therapeutic use; D006801:Humans; D008852:Microradiography; D013997:Time Factors; D014089:Tooth Remineralization
chemical_list: D002130:Calcium Phosphates; D002327:Cariostatic Agents; D004164:Diphosphonates; C029285:hydroxymethanediphosphonic acid; C020243:calcium phosphate; D005459:Fluorides; D002118:Calcium