Microbial subversion of heparan sulfate proteoglycans.
The interactions between the host and microbial pathogen largely dictate the onset, progression, and outcome of infectious diseases. Pathogens subvert host components to promote their pathogenesis and, among these, cell surface heparan sulfate proteoglycans are exploited by many pathogens for their initial attachment and subsequent cellular entry. The ability to interact with heparan sulfate proteoglycans is widespread among viruses, bacteria, and parasites. Certain pathogens also use heparan sulfate proteoglycans to evade host defense mechanisms. These findings suggest that heparan sulfate proteoglycans are critical in microbial pathogenesis, and that heparan sulfate proteoglycan-pathogen interactions are potential targets for novel prophylactic and therapeutic approaches.
Chen
Ye
Y
Department of Digestive Diseases, Nanfang Hospital, Southemrn Medical University, Guangzhou, People's Republic of China.
Götte
Martin
M
Liu
Jian
J
Park
Pyong Woo
PW
D000818:Animals; D001419:Bacteria / Q000378:metabolism*; D019812:Heparan Sulfate Proteoglycans / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D010271:Parasites; D014780:Viruses / Q000378:metabolism*
D019812:Heparan Sulfate Proteoglycans
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