title: Drug-eluting coronary stent very late thrombosis revisited.
abstract: Compared to bare-metal stents (BMS), drug-eluting stents (DES) provide a significant additional reduction in restenosis rates and the need for coronary reinterventions. However, compared to BMS, the risk of very late stent thrombosis (ST) appears to be marginally higher accounting for 0.2-0.6% annual incidence for up to 3 years and possibly even longer following implantation. Risk reduction strategies include meticulous implantation technique, identification of patients with increased thrombotic risk, exclusion of patients scheduled in short term for major elective surgeries, and extended dual antithrombotic treatment for a minimum of 12 months. Future risk avoidance strategies are briefly reviewed and commented.
authors.affiliation: Department of Internal Medicine, Hospitals and Clinics, Bitterfeld-Wolfen, Germany. planzer@gzbiwo.de
authors.forename: Peter
authors.initials: P
authors.lastname: Lanzer
authors.forename: Katrin
authors.initials: K
authors.lastname: Sternberg
authors.forename: Klaus-Peter
authors.initials: KP
authors.lastname: Schmitz
authors.forename: Frank
authors.initials: F
authors.lastname: Kolodgie
authors.forename: Gaku
authors.initials: G
authors.lastname: Nakazawa
authors.forename: Renu
authors.initials: R
authors.lastname: Virmani
mesh_terms: D023921:Coronary Stenosis / Q000209:etiology* / Q000517:prevention & control*; D003328:Coronary Thrombosis / Q000209:etiology* / Q000517:prevention & control*; D054855:Drug-Eluting Stents / Q000009:adverse effects*; D006801:Humans