title: An oncogenic role for the multiple endocrine neoplasia type 1 gene in prostate cancer.
abstract: Prostate cancer is the second leading cause of cancer related deaths in US men, largely because of metastasis, which is ultimately fatal. A better understanding of metastasis biology will lead to improved prognostication and therapeutics. We previously reported 11q13.1 gain was independently predictive of recurrence after radical prostatectomy. Multiple endocrine neoplasia I (MEN1) maps to this region of copy number gain in aggressive prostate tumors and was shown to be the only gene at this locus at increased expression in prostate cancer. Here, we demonstrate an oncogenic role for MEN1 in prostate cancer using a variety of independent assays.
authors.affiliation: Department of Urology, University of California at San Francisco Comprehensive Cancer Center, UCSF, San Francisco, CA 94143, USA.
authors.forename: P L
authors.initials: PL
authors.lastname: Paris
authors.forename: S
authors.initials: S
authors.lastname: Sridharan
authors.forename: A B
authors.initials: AB
authors.lastname: Hittelman
authors.forename: Y
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: S
authors.initials: S
authors.lastname: Perner
authors.forename: G
authors.initials: G
authors.lastname: Huang
authors.forename: J
authors.initials: J
authors.lastname: Simko
authors.forename: P
authors.initials: P
authors.lastname: Carroll
authors.forename: M A
authors.initials: MA
authors.lastname: Rubin
authors.forename: C
authors.initials: C
authors.lastname: Collins
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D045744:Cell Line, Tumor; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D011471:Prostatic Neoplasms / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D034741:RNA, Small Interfering; D020133:Reverse Transcriptase Polymerase Chain Reaction; D046888:Tissue Array Analysis
chemical_list: D014408:Biomarkers, Tumor; C105373:MEN1 protein, human; D011518:Proto-Oncogene Proteins; D034741:RNA, Small Interfering
references.citation: J Clin Oncol. 1999 May;17(5):1499-507
references.pmid: 10334537
references.citation: Neoplasia. 2008 Mar;10(3):298-302
references.pmid: 18320074
references.citation: Nat Genet. 2007 Jan;39(1):41-51
references.pmid: 17173048
references.citation: Science. 2007 Nov 2;318(5851):806-9
references.pmid: 17975067
references.citation: Mol Cell. 2004 Feb 27;13(4):587-97
references.pmid: 14992727
references.citation: J Biol Chem. 2004 Mar 12;279(11):10685-91
references.pmid: 14688275
references.citation: J Intern Med. 1998 Jun;243(6):477-88
references.pmid: 9681846
references.citation: Proc Natl Acad Sci U S A. 2004 Jan 20;101(3):811-6
references.pmid: 14711987
references.citation: J Intern Med. 2003 Jun;253(6):606-15
references.pmid: 12755956
references.citation: Nat Genet. 2001 Nov;29(3):263-4
references.pmid: 11687795
references.citation: Cancer Cell. 2005 Nov;8(5):393-406
references.pmid: 16286247
references.citation: Genome Res. 2003 Sep;13(9):2129-41
references.pmid: 12952881
references.citation: Cell. 1999 Jan 8;96(1):143-52
references.pmid: 9989505
references.citation: Hum Mutat. 2008 Jan;29(1):22-32
references.pmid: 17879353
references.citation: Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W645-50
references.pmid: 16912992
references.citation: Mol Cell Biol. 2004 Jul;24(13):5639-49
references.pmid: 15199122
references.citation: Endocr Relat Cancer. 1999 Dec;6(4):449-73
references.pmid: 10730900
references.citation: J Intern Med. 1998 Jun;243(6):433-9
references.pmid: 9681840
references.citation: Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1630-4
references.pmid: 9465067
references.citation: Cancer Res. 2003 Jul 15;63(14):3877-82
references.pmid: 12873976
references.citation: QJM. 1996 Sep;89(9):653-69
references.pmid: 8917740
references.citation: Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):749-54
references.pmid: 15640349
references.citation: Nature. 2001 Aug 23;412(6849):822-6
references.pmid: 11518967
references.citation: Cancer Res. 2001 Jun 15;61(12):4683-8
references.pmid: 11406537
references.citation: Gastroenterology. 1995 Jun;108(6):1637-49
references.pmid: 7768367
references.citation: Clin Cancer Res. 2000 Mar;6(3):1038-45
references.pmid: 10741732
references.citation: Hum Mol Genet. 2004 Jul 1;13(13):1303-13
references.pmid: 15138198
references.citation: Trends Endocrinol Metab. 2001 May-Jun;12(4):173-8
references.pmid: 11295574
references.citation: Oncogene. 2006 Jun 15;25(25):3537-46
references.pmid: 16449969
references.citation: Cell. 2005 Oct 21;123(2):207-18
references.pmid: 16239140
references.citation: N Engl J Med. 1999 Aug 26;341(9):635-44
references.pmid: 10460814
references.citation: Bioinformatics. 2003 Jan 22;19(2):185-93
references.pmid: 12538238
references.citation: Nature. 1988 Mar 3;332(6159):85-7
references.pmid: 2894610
references.citation: FASEB J. 2005 Feb;19(2):243-5
references.pmid: 15548588