title: E-box protein E2-2 is a crucial regulator of plasmacytoid DC development.
abstract: DC play central roles in priming both innate and adaptive immune responses. Multiple DC subsets have been identified on the basis of their phenotype and function. Plasmacytoid DC (pDC) are professional IFN-producing cells that play an essential role in anti-viral immunity. A series of recent studies demonstrates that the regulation of pDC development is different from other types of DC. In this issue of the European Journal of Immunology, new insight is provided into how human pDC development is regulated by various transcription factors, in particular by the Ets family protein Spi-B and E-box protein E2-2.
authors.affiliation: Department of Immunology and Center for Cancer Immunology Research, University of Texas, M. D. Anderson Cancer Center, Houston, TX 77030, USA. eesashi@mdanderson.org
authors.forename: Eiji
authors.initials: E
authors.lastname: Esashi
authors.forename: Yong-Jun
authors.initials: YJ
authors.lastname: Liu
mesh_terms: D004268:DNA-Binding Proteins / Q000378:metabolism*; D003713:Dendritic Cells / Q000166:cytology* / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism; D051820:TCF Transcription Factors / Q000378:metabolism*; D058118:Transcription Factor 7-Like 2 Protein; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D051820:TCF Transcription Factors; C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein; D014157:Transcription Factors; C076877:SPIB protein, human
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