The diverse roles of protein kinase C in pancreatic beta-cell function.
Members of the serine/threonine PKC (protein kinase C) family perform diverse functions in multiple cell types. All members of the family are activated in signalling cascades triggered by occupation of cell surface receptors, but the cPKC (conventional PKC) and nPKC (novel PKC) isoforms are also responsive to fatty acid metabolites. PKC isoforms are involved in various aspects of pancreatic beta-cell function, including cell proliferation, differentiation and death, as well as regulation of secretion in response to glucose and muscarinic receptor agonists. Recently, the nPKC isoform, PKCepsilon, has also been implicated in the loss of insulin secretory responsiveness that underpins the development of Type 2 diabetes.
Biden
Trevor J
TJ
Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia. t.biden@garvan.org.au
Schmitz-Peiffer
Carsten
C
Burchfield
James G
JG
Gurisik
Ebru
E
Cantley
James
J
Mitchell
Christopher J
CJ
Carpenter
Lee
L
D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000503:physiopathology; D005947:Glucose / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D007527:Isoenzymes / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D011493:Protein Kinase C / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
D007328:Insulin; D007527:Isoenzymes; D011493:Protein Kinase C; D005947:Glucose