Pathophysiology and treatment of painful diabetic neuropathy.
Diabetes is the most common cause of peripheral neuropathy, and painful diabetic neuropathy (PDN) affects approximately 30% of diabetic patients with neuropathy. It is extremely distressing for the patient and poses significant management difficulties because no treatment provides total relief, and side effects of therapy are a major limiting factor for titrating therapy. Understanding the pathogenesis of diabetic neuropathy may lead to the development of new treatments to prevent nerve damage, and a better understanding of the mechanisms that modulate pain may lead to more effective relief of painful symptoms. We provide an update on the pathogenesis, diagnosis, and treatment of PDN.
Tavakoli
Mitra
M
Division of Cardiovascular Medicine, University of Manchester, Manchester, UK.
Mojaddidi
Moaz
M
Fadavi
Hassan
H
Malik
Rayaz A
RA
D000818:Animals; D048909:Diabetes Complications / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D003929:Diabetic Neuropathies / Q000235:genetics / Q000503:physiopathology* / Q000628:therapy*; D020022:Genetic Predisposition to Disease; D006801:Humans
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