title: Relationship between brachial-ankle pulse wave velocity and cognitive function in an elderly community-dwelling population with metabolic syndrome.
abstract: Arterial stiffness (AS) and metabolic syndrome (MS) may correlate with poor cognitive function in elderly people. However, few studies have evaluated this relationship in a healthy, community-dwelling elderly population. Our aim was to evaluate a relationship between the AS measured by pulse wave velocity (PWV) and cognitive function and to know whether the relationship is influenced by the presence of MS. Our study population was community-dwelling healthy people in Geumsan province, Republic of Korea. A total of 370 participants without a history of cerebrovascular disease were evaluated with the Korean version of the mini-mental state examination (K-MMSE) and have measured the brachial-ankle PWV (baPWV). Correlation between baPWV and cognitive status and effect of MS were measured. Negative correlation between PWV and cognitive function was found in the older subjects (> or = 60 years of age) with MS (r=-0.38; p<0.05). In the receiver operating characteristic (ROC) curve, the cut-off score was 1800.8 cm/s with 67% sensitivity and 78% specificity. Aging (older than 60 years) and the presence of MS may affect synergistically cognitive decline in the elderly population. The baPWV can be a useful predictor for cognitive decline in elderly healthy community-dwelling population with MS.
authors.affiliation: Department of Neurology, Chungnam National University Hospital, College of Medicine, 640 Daesa-dong, Jung-gu, Daejeon 301-721, Republic of Korea.
authors.forename: Ye-Sung
authors.initials: YS
authors.lastname: Kim
authors.forename: Dae-Hyun
authors.initials: DH
authors.lastname: Kim
authors.forename: Byung Hee
authors.initials: BH
authors.lastname: Choi
authors.forename: Eun-Hee
authors.initials: EH
authors.lastname: Sohn
authors.forename: Ae Young
authors.initials: AY
authors.lastname: Lee
mesh_terms: D000368:Aged; D000842:Ankle / Q000098:blood supply*; D001916:Brachial Artery; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D009483:Neuropsychological Tests; D011674:Pulse; D012372:ROC Curve; D012111:Residence Characteristics; D012720:Severity of Illness Index