[History for animal model of Hansen's disease and characteristics of leprosy in hypertensive nude rat].
The long search of an animal model for leprosy were carried out as many researchers since the Mycobacterium leprae discovery by Dr. Hansen in 1874. The remarkable results were left after the development of the foot-pad method by Dr. Shepard in 1960. The introduction of the T-R mouse and athymic (nude) mouse for leprosy research, alsospontaneity examples of Hansen's disease was reported to armadillo, chimpanzee and mangabay monkey, and it was confirmed that Hansen's disease was the zoonosis. Although, We have established a congenic hypertensive nude rat, SHR/NCrj-rnu (SHR.F344-Foxn(rnu)), carrying nude (rnu) and hypertension genes. SHR/NCrj-rnu rats obtained showed high susceptibility to M. leprae and showed a characteristic disease with a progressive pattern of leproma formation. Also this hypertensive nude rat strain produce high level of IL-10. Therefore, congenic hypertensive nude rat may be useful for an animal model to leprosy.
Yogi
Yasuko
Y
Leprosy Research Center, National Institute of Infectious Diseases, 1-6-7-502 Hirose, Sayama, Saitama 350-1319, Japan. yyogi2006@ybb.ne.jp
Fujimura
Takao
T
Suzuki
Koichi
K
D000818:Animals; D004195:Disease Models, Animal; D049673:History, 20th Century; D016753:Interleukin-10 / Q000096:biosynthesis; D007918:Leprosy / Q000266:history* / Q000382:microbiology / Q000473:pathology; D051379:Mice; D009166:Mycobacterium leprae / Q000254:growth & development; D051381:Rats; D011918:Rats, Inbred SHR / Q000378:metabolism / Q000382:microbiology; D011923:Rats, Nude / Q000378:metabolism / Q000382:microbiology
D016753:Interleukin-10