title: Cytologic diagnosis of metastatic seminoma to the prostate and urinary bladder: a case report.
abstract: A 42-year-old man presented with severe abdominal pain, constipation, and hematuria. The patient had a history of seminoma treated by chemotherapy followed by bilateral orchiectomy and retroperitoneal lymph node dissection 16 years earlier. A computed tomography (CT) scan showed a 8.0 x 6.0 x 5.0 cm mass in the retrovesical space, encompassing the left side of his proximal bladder, the prostate, and the rectum. A urine cytologic specimen showed loosely cohesive cell clusters composed of highly atypical large cells and occasional large, single cells with macronucleoli present in a background of mainly lymphocytes and histiocytes was diagnosed as recurrent seminoma. Prostate biopsies showed extensively necrotic seminoma with accompanying granulomatous reaction. The tumor cells were immunoreactive for c-kit (CD117), placental-like alkaline phosphatase (PLAP), D2-40, and OCT4. To our knowledge, this is the second report on urine cytology of metastatic seminoma.
authors.affiliation: Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455, USA.
authors.forename: Mariam
authors.initials: M
authors.lastname: Alsharif
authors.forename: Deniz L
authors.initials: DL
authors.lastname: Aslan
authors.forename: Jose
authors.initials: J
authors.lastname: Jessurun
authors.forename: H Evin
authors.initials: HE
authors.lastname: Gulbahce
authors.forename: Stefan E
authors.initials: SE
authors.lastname: Pambuccian
mesh_terms: D000328:Adult; D000469:Alkaline Phosphatase / Q000378:metabolism; D001706:Biopsy; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D008297:Male; D050814:Octamer Transcription Factor-3 / Q000378:metabolism; D011467:Prostate / Q000378:metabolism / Q000473:pathology; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000556:secondary* / Q000652:urine; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism; D018239:Seminoma / Q000175:diagnosis* / Q000556:secondary* / Q000652:urine; D013736:Testicular Neoplasms / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000556:secondary* / Q000652:urine; D014556:Urine / Q000166:cytology
chemical_list: D007527:Isoenzymes; D050814:Octamer Transcription Factor-3; C494173:POU5F1 protein, human; C055791:germ-cell AP isoenzyme; D019009:Proto-Oncogene Proteins c-kit; D000469:Alkaline Phosphatase