title: TGF-beta3: A promising growth factor in engineered organogenesis.
abstract: BACKGROUND
  Engineered organogenesis is one of the most challenging areas on the cutting edge of regenerative medicine. Growth factors can affect cell proliferation, migration and differentiation profoundly, and thus play a critical role in tissue regeneration. TGF-betas produce a wide range of effects in different cells and tissues. TGF-beta3 is relatively recently discovered and studied.
  
  
  OBJECTIVE
  To provide a broader understanding of the current state of TGF-beta3 in engineered osteogenesis, chondrogenesis, palate development, scar-free wound healing, odontogenesis and neurogenesis.
  
  
  METHODS
  This review summarizes studies that explore or apply TGF-beta3 for organogenesis with engineering methodology and a regenerative medical perspective.
  
  
  CONCLUSIONS
  TGF-beta3 has proven to be a competent growth factor in engineered organogenesis in vitro. In recent years, using TGF-beta3, more and more in vivo studies have yielded significant therapeutic achievements in animal models, which bear much promise for future medical application.
authors.affiliation: Nanyang Technological University, School of Chemical and Biomedical Engineering, Division of Bioengineering, 70 Nanyang Drive, N1.3-B2-13, Singapore 637457, Republic of Singapore.
authors.forename: Jinghua
authors.initials: J
authors.lastname: Hao
authors.forename: Rohan R
authors.initials: RR
authors.lastname: Varshney
authors.forename: Dong-An
authors.initials: DA
authors.lastname: Wang
mesh_terms: D002454:Cell Differentiation / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D011994:Recombinant Proteins / Q000494:pharmacology; D023822:Tissue Engineering; D014070:Tooth / Q000254:growth & development; D053782:Transforming Growth Factor beta3 / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D011994:Recombinant Proteins; D053782:Transforming Growth Factor beta3