title: [Synthesis of 1,3-dihydro-1,3-dioxo-2H-isoindole derivatives].
abstract: OBJECTIVE
  To synthesize a series of derivatives of Thalidomide.
  
  
  METHODS
  The N-Phthaloyl-L-glutamic anhydride was ammonolyzed with amino acid benzyl esters, followed by hydrogenization. The reaction between the hydogenized products and ammonia gas produced ammonium salt, 1,3-dihydro-1,3-dioxo-2H-isoindole derivatives.
  
  
  RESULTS
  Four new derivatives of Thalidomide were obtained and confirmed by spectral detection.
  
  
  CONCLUSIONS
  The derivatives of Thalidomide can be efficiently synthesized under mild conditions.
authors.affiliation: The Central Teaching Laboratory for Modern Pharmacy, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Yang
authors.forename: Dong
authors.initials: D
authors.lastname: Xiang
authors.forename: Ju
authors.initials: J
authors.lastname: Guo
authors.forename: Yong-sheng
authors.initials: YS
authors.lastname: Zheng
authors.forename: Bin
authors.initials: B
authors.lastname: Ye
authors.forename: Jin-liang
authors.initials: JL
authors.lastname: Yang
authors.forename: Li
authors.initials: L
authors.lastname: Cheng
mesh_terms: D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D008956:Models, Chemical; D015394:Molecular Structure; D010797:Phthalimides / Q000138:chemical synthesis* / Q000737:chemistry; D013792:Thalidomide / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D020533:Angiogenesis Inhibitors; D010797:Phthalimides; D013792:Thalidomide