Dietary fat and risk of renal cell carcinoma in the USA: a case-control study.
An increased risk of renal cell carcinoma (RCC) has been linked with obesity. However, there is limited information about the contribution of dietary fat and fat-related food groups to RCC risk. A population-based case-control study of 406 cases and 2434 controls aged 40-85 years was conducted in Iowa (1986-89). For 323 cases and 1820 controls from the present study, information on dietary intake from foods high in fat nutrients and other lifestyle factors was obtained using a mailed questionnaire. Cancer risks were estimated by OR and 95 % CI, adjusting for age, sex, smoking, obesity, hypertension, physical activity, alcohol and vegetable intake and tea and coffee consumption. In all nutrient analyses, energy density estimates were used. Dietary nutrient intake of animal fat, saturated fat, oleic acid and cholesterol was associated with an elevated risk of RCC (OR = 1.9, 95 % CI 1.3, 2.9, P trend < 0.001; OR = 2.6, 95 % CI 1.6, 4.0, P trend < 0.001; OR = 1.9, 95 % CI 1.2, 2.9, P trend = 0.01; OR = 1.9, 95 % CI 1.3, 2.8, P trend = 0.006, respectively, for the top quartile compared with the bottom quartile of intake). Increased risks were also associated with high-fat spreads, red and cured meats and dairy products (OR = 2.0, 95 % CI 1.4, 3.0, P trend = 0.001; OR = 1.7, 95 % CI 1.0, 2.2, P trend = 0.01; OR = 1.8, 95 % CI 1.2, 2.7, P trend = 0.02; OR = 1.6, 95 % CI 1.1, 2.3, P trend = 0.02, respectively). In both the food groups and nutrients, there was a significant dose-response with increased intake. Our data also indicated that the association of RCC with high-fat spreads may be stronger among individuals with hypertension. These findings deserve further investigation in prospective studies.
Brock
Kaye E
KE
Department of Behavioural and Community Health Sciences, Faculty of Heath Sciences, University of Sydney, Sydney, NSW, Australia. k.brock@usyd.edu.au
Gridley
Gloria
G
Chiu
Brian C-H
BC
Ershow
Abby G
AG
Lynch
Charles F
CF
Cantor
Kenneth P
KP
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000453:epidemiology / Q000209:etiology*; D016022:Case-Control Studies; D015986:Confounding Factors, Epidemiologic; D004041:Dietary Fats / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000453:epidemiology; D007484:Iowa / Q000453:epidemiology; D007680:Kidney Neoplasms / Q000453:epidemiology / Q000209:etiology*; D008019:Life Style; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D004041:Dietary Fats
Ann Oncol. 2007 Mar;18(3):596-600
17158772
Cancer Causes Control. 2002 Apr;13(3):287-93
12020111
J Nutr. 2005 Jul;135(7):1757-62
15987861
Am J Public Health. 1984 Jan;74(1):52-6
6689843
Free Radic Biol Med. 2006 Feb 15;40(4):721-33
16458203
Epidemiology. 1990 Nov;1(6):430-40
2090280
Int J Cancer. 2007 Feb 1;120(3):681-5
17058282
Epidemiology. 1997 Jan;8(1):31-6
9116091
Br J Cancer. 2001 Sep 28;85(7):984-90
11592770
Int J Cancer. 1998 Jul 17;77(2):211-6
9650554
Cancer Causes Control. 1993 Nov;4(6):505-11
8280827
Cancer Causes Control. 2003 Oct;14(8):705-14
14674734
Cancer Causes Control. 1990 Sep;1(2):133-41
2102283
Epidemiology. 2004 Sep;15(5):529-35
15308951
Int J Cancer. 1975 Apr 15;15(4):617-31
1140864
J Natl Cancer Inst. 2007 May 16;99(10):801-10
17505075
Int J Urol. 2002 Sep;9(9):509-14
12410931
Am J Clin Nutr. 1999 Sep;70(3 Suppl):532S-538S
10479227
Public Health Nutr. 2002 Dec;5(6):757-67
12570884
Am J Public Health. 1994 Mar;84(3):469-72
8129069
Cancer Invest. 2005;23(3):240-55
15945510
Ann Epidemiol. 2003 Apr;13(4):245-51
12684190
Am J Epidemiol. 1989 Nov;130(5):1033-46
2816890
Am J Med. 2002 Apr 15;112(6):479-86
11959059
Eur J Cancer. 1996 Apr;32A(4):673-82
8695272
Cancer. 1995 May 15;75(10):2552-7
7736400
Am J Epidemiol. 1999 Mar 15;149(6):531-40
10084242
Hypertension. 2004 Oct;44(4):398-404
15326093
N S W Public Health Bull. 2004 May-Jun;15(5-6):107
15543245
Int J Cancer. 2004 Jan 1;108(1):115-21
14618625
J Natl Cancer Inst. 1994 Aug 3;86(15):1131-9
8028035
JAMA. 2006 Sep 20;296(11):1371-6
16985229
Cancer Causes Control. 1990 Sep;1(2):125-31
2102282
Cancer Res. 1985 Jul;45(7):3288-95
3891081
Diabetologia. 1999 Jan;42(1):107-12
10027588
Br J Cancer. 2007 Aug 6;97(3):429-33
17653076
Atherosclerosis. 2000 Jun;150(2):227-43
10856515
Endocrinology. 1979 Feb;104(2):390-5
221176
Jpn J Cancer Res. 1994 Dec;85(12):1304-11
7852193
Z Ernahrungswiss. 1997 Mar;36(1):3-11
9095533
Br J Cancer. 1998 Nov;78(9):1239-43
9820187
Med Sci Sports Exerc. 1999 Nov;31(11 Suppl):S509-14
10593520
J Epidemiol. 2005 Jun;15 Suppl 2:S203-11
16127235
Int J Cancer. 1996 Jan 3;65(1):67-73
8543399
Public Health Nutr. 2007 Feb;10(2):158-67
17261225
IARC Sci Publ. 1980;(32):5-338
7216345
Cancer Epidemiol Biomarkers Prev. 1997 Apr;6(4):215-23
9107425
Obes Res Clin Pract. 2007 May;1(2):I-II
24351456