title: Novelty-induced locomotion is positively associated with cocaine ingestion in adolescent rats; anxiety is correlated in adults.
abstract: The present studies assessed the roles of sex, age, novelty-seeking and plus-maze behavior on cocaine drinking in rats. Cocaine/saccharin solution was available in three daily, 5-hour sessions then a saccharin-only solution was also available in following sessions. In the one-bottle drinking phase, early and late adolescent males, post-natal day 28 (PN28) and PN42, consumed more cocaine/saccharin solution than young adults (PN65), but females did not exhibit significant age differences. Adolescents of both sexes consumed more cocaine/saccharin than adults during choice drinking. Saccharin availability in the two-bottle trials decreased cocaine/saccharin consumption in PN28 and PN65 rats. After a drug-free period, cocaine-stimulated locomotion was lower in cocaine/saccharin drinking than saccharin-only males, indicating tolerance. We tested the hypothesis that individual differences in pre-screened behavioral traits would correlate with cocaine/saccharin consumption in PN28 and PN65 male rats. High locomotor responses to novelty were associated with greater cocaine/saccharin drinking in adults in one-bottle sessions. In the subsequent choice drinking phase, correlations were age-specific. Adolescents with high novelty-induced locomotion and adults that spent less time on open arms of the elevated plus-maze drank more cocaine/saccharin. Thus, behavioral phenotypes correlated with individual differences in cocaine/saccharin consumption in an age-related manner.
authors.affiliation: Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, United States.
authors.forename: Q David
authors.initials: QD
authors.lastname: Walker
authors.forename: Nicole L
authors.initials: NL
authors.lastname: Schramm-Sapyta
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Caster
authors.forename: Samuel T
authors.initials: ST
authors.lastname: Waller
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Brooks
authors.forename: Cynthia M
authors.initials: CM
authors.lastname: Kuhn
mesh_terms: D000375:Aging / Q000523:psychology*; D000818:Animals; D001007:Anxiety / Q000523:psychology*; D003042:Cocaine / Q000737:chemistry / Q000494:pharmacology; D019970:Cocaine-Related Disorders / Q000523:psychology*; D003627:Data Interpretation, Statistical; D004777:Environment; D005260:Female; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D019999:Pharmaceutical Solutions; D051381:Rats; D012201:Reward; D012727:Sex Characteristics
chemical_list: D019999:Pharmaceutical Solutions; D003042:Cocaine
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