Building biologically active nucleic acid nanocomplexes.
The Bioplex technology allows the hybridization of functional entities to various forms of nucleic acids by the use of synthetic nucleic acid analogs. Such supramolecular assemblies can be made in a predetermined fashion and can confer new properties. The Zorro technology is based on a novel construct generated to simultaneously bind to both DNA strands. Such compounds may have gene silencing activity.
Smith
C I Edvard
CI
Department of Laboratory Medicine, Clinical Research Center, Karolinska Institutet, Karolinska University Hospital, 141 86 Huddinge, Sweden.
Lundin
Karin E
KE
Simonson
Oscar E
OE
Moreno
Pedro M D
PM
Svahn
Mathias G
MG
Wenska
Malgorzata
M
Strömberg
Roger
R
D021581:Active Transport, Cell Nucleus; D002467:Cell Nucleus / Q000378:metabolism; D004247:DNA / Q000737:chemistry; D020868:Gene Silencing; D049329:Nanostructures / Q000737:chemistry*; D009693:Nucleic Acid Hybridization; D009696:Nucleic Acids / Q000378:metabolism; D009841:Oligonucleotides / Q000737:chemistry*; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D010957:Plasmids / Q000737:chemistry
D009696:Nucleic Acids; D009841:Oligonucleotides; D020135:Peptide Nucleic Acids; C477371:locked nucleic acid; D004247:DNA