Leptin as an endocrine signal in bone.
Leptin and its actions in bone came to prominence in 2000, with the publication of two landmark articles identifying a novel interaction between energy and bone homeostasis, as well as a novel hypothalamic circuit to the skeleton. However, they also revealed the dichotomous nature of leptin's effect on the skeleton. Subsequent research has increased understanding of the factors critical to interpretation of the leptin-bone signaling. These include opposing effects in cortical and cancellous bone, central and peripheral effects, involvement of other neural and endocrine factors, and leptin receptor polymorphisms in human populations. It is clear that leptin can markedly influence the regulation of bone mass, and that study of this pathway continues to increase our knowledge of the biology of skeletal tissue and its interactions with other tissues. However, this relationship is complex and requires careful interpretation.
Lee
Nicola J
NJ
Neuroscience Research Program, Garvan Institute of Medical Research, St. Vincent's Hospital, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia.
Wong
Iris P L
IP
Baldock
Paul A
PA
Herzog
Herbert
H
D000818:Animals; D015519:Bone Density / Q000235:genetics / Q000502:physiology*; D001842:Bone and Bones / Q000502:physiology*; D006801:Humans; D020738:Leptin / Q000502:physiology*; D023421:Models, Animal; D009478:Neuropeptide Y / Q000502:physiology; D011110:Polymorphism, Genetic; D054411:Receptors, Leptin / Q000235:genetics
D020738:Leptin; D009478:Neuropeptide Y; D054411:Receptors, Leptin
Nature. 1995 Oct 12;377(6549):530-2
7566151
J Bone Miner Res. 2002 Jun;17(6):1034-43
12054158
FEBS Lett. 2002 Sep 25;528(1-3):43-7
12297277
J Biol Chem. 2007 Jun 29;282(26):19082-91
17491022
Menopause. 2007 May-Jun;14(3 Pt 1):450-4
17242633
Peptides. 2007 May;28(5):1012-9
17346852
Osteoporos Int. 2007 May;18(5):641-7
17139464
Am J Physiol. 1983 Aug;245(2):E148-54
6881329
J Cell Biochem. 2003 Mar 1;88(4):706-12
12577304
Diabetes. 1999 Sep;48(9):1787-93
10480609
EXS. 2006;(95):171-82
16383006
J Clin Endocrinol Metab. 1997 Oct;82(10):3239-45
9329346
Endocrinology. 1993 May;132(5):1939-44
7682936
J Biol Chem. 2007 Jun 29;282(26):19092-102
17491016
Obesity (Silver Spring). 2006 Aug;14 Suppl 5:234S-237S
17021373
Endocrinology. 2008 Feb;149(2):634-41
17991723
Eur J Endocrinol. 2006 May;154(5):707-14
16645018
J Bone Miner Res. 2007 Apr;22(4):544-50
17243864
J Clin Endocrinol Metab. 2003 Dec;88(12):5795-800
14671171
Bone. 2001 Aug;29(2):114-20
11502471
J Endocrinol. 2002 Nov;175(2):405-15
12429038
Lancet. 2006 Jun 17;367(9527):2010-8
16782492
Biochem Biophys Res Commun. 2005 Mar 18;328(3):697-9
15694403
Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):11073-8
9380761
Endocrinology. 1999 Apr;140(4):1630-8
10098497
Blood Cells Mol Dis. 2000 Jun;26(3):234-46
10950944
Osteoporos Int. 2008 Jul;19(7):905-12
17924050
Cell. 2000 Jan 21;100(2):197-207
10660043
Clin Endocrinol (Oxf). 2004 Aug;61(2):204-8
15272915
Calcif Tissue Int. 2004 May;74(5):401-6
15164730
Menopause. 2007 Jan-Feb;14(1):38-44
17075432
J Bone Miner Res. 2006 Oct;21(10):1600-7
16995815
J Histochem Cytochem. 2002 Feb;50(2):159-69
11799135
Diabetes. 1999 Apr;48(4):828-33
10102700
J Bone Miner Res. 2005 Oct;20(10):1851-7
16160743
Ann Plast Surg. 2007 Sep;59(3):329-33
17721225
J Bone Miner Res. 2006 May;21(5):758-64
16734391
J Bone Miner Res. 2006 Dec;21(12):1871-8
17002557
J Clin Invest. 2002 Apr;109(7):915-21
11927618
J Bone Miner Res. 2004 Apr;19(4):546-51
15005840
J Cell Biochem. 2002;85(4):825-36
11968022
J Cell Biochem. 2005 Jan 1;94(1):50-7
15517602
Peptides. 2007 Feb;28(2):320-5
17197054
Endocrinology. 2002 Nov;143(11):4161-4
12399407
Cell Tissue Res. 2007 Jan;327(1):133-41
17024416
J Anat. 2004 Oct;205(4):291-6
15447688
J Clin Endocrinol Metab. 2007 Nov;92(11):4380-6
17785359
Cell. 2002 Nov 1;111(3):305-17
12419242
J Clin Endocrinol Metab. 2003 Feb;88(2):599-604
12574187
J Clin Endocrinol Metab. 2001 Nov;86(11):5273-6
11701691
Regul Pept. 2000 Aug 25;92(1-3):73-8
11024568
Hum Genet. 2001 Mar;108(3):233-6
11354636
Eur J Endocrinol. 2002 Dec;147(6):777-83
12457453
Nat Genet. 1996 Sep;14(1):95-7
8782827
J Bone Miner Res. 2001 Aug;16(8):1426-33
11499865
Exp Biol Med (Maywood). 2006 Nov;231(10):1673-7
17060689
Horm Res. 2003;60(2):91-8
12876420