[Toxic effect of Abeta25-35 and fullerene C60 on erythrocytes].
Using light microscopy and spectrophotometry, it has been shown that amyloid beta-peptide Abeta25-35 and water-soluble fullerene C60 cause lysis of human and rat erythrocytes. Both fullerene C60 and Abeta25-35 partly inhibited the activities of membrane-associated phosphofructokinase and plasmalemmal lactate dehydrogenase in erythrocytes.
Solomadin
I N
IN
Marov
N V
NV
Venediktova
N I
NI
Kosenko
E A
EA
Kaminskiĭ
Iu G
IuG
D016229:Amyloid beta-Peptides / Q000633:toxicity*; D000818:Animals; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000648:ultrastructure; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D037741:Fullerenes / Q000633:toxicity*; D006801:Humans; D066298:In Vitro Techniques; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D018696:Neuroprotective Agents / Q000633:toxicity*; D010446:Peptide Fragments / Q000633:toxicity*; D051381:Rats
D016229:Amyloid beta-Peptides; D037741:Fullerenes; D008565:Membrane Proteins; D018696:Neuroprotective Agents; D010446:Peptide Fragments; C074636:amyloid beta-protein (25-35); D007770:L-Lactate Dehydrogenase; C069837:fullerene C60