The development and genetic diversity of H5N1 influenza virus in China, 1996-2006.
Since it was first detected in 1996, the Goose/Guangdong/1/1996 (Gs/GD) H5N1 influenza virus and its reassortants have spread to over 60 countries, with over 20 distinct genetic reassortants previously recognized. However, systematic analysis of their interrelationship and the development of genetic diversity have not been explored. As each of those reassortants was first detected in China, here 318 full-length H5N1 virus genomes isolated from 1996 to 2006 in this region were phylogenetically analyzed. Our findings revealed two major group reassortment events in 2001 and 2002 that were responsible for the generation of the majority of the 44 distinct Gs/GD genotypes identified, excepting those 1997 variants. Genotype replacement and emergence occurred continually, with 34 transient genotypes detected while only 10 variants were persistent. Two major replacements of predominant genotypes were also observed: genotype B replaced by Z in 2002 and then genotype Z replaced by the now predominant genotype V in 2005.
Duan
L
L
International Institute of Infection and Immunity, Shantou University Medical College, Shantou 515031, Guangdong, China.
Bahl
J
J
Smith
G J D
GJ
Wang
J
J
Vijaykrishna
D
D
Zhang
L J
LJ
Zhang
J X
JX
Li
K S
KS
Fan
X H
XH
Cheung
C L
CL
Huang
K
K
Poon
L L M
LL
Shortridge
K F
KF
Webster
R G
RG
Peiris
J S M
JS
Chen
H
H
Guan
Y
Y
D002681:China; D019143:Evolution, Molecular; D014644:Genetic Variation; D016679:Genome, Viral; D005838:Genotype; D053124:Influenza A Virus, H5N1 Subtype / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D016865:Reassortant Viruses / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D017422:Sequence Analysis, DNA; D017385:Sequence Homology
D012367:RNA, Viral
J Virol. 2007 Jul;81(14):7529-39
17507485
J Virol. 2003 Jun;77(12):6988-94
12768017
J Virol. 2000 Jul;74(14):6309-15
10864640
Nature. 2004 Jul 8;430(6996):209-13
15241415
Science. 1998 Jan 16;279(5349):393-6
9430591
Virology. 1998 Dec 20;252(2):331-42
9878612
Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2845-50
16473931
J Virol. 2008 Apr;82(7):3769-74
18234791
Vaccine. 2007 Jul 26;25(30):5637-44
17126960
J Virol. 2008 Jan;82(2):596-601
17942553
Microbes Infect. 2004 Aug;6(10):919-25
15310468
J Gen Virol. 2001 Mar;82(Pt 3):623-630
11172104
Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1356-61
14745020
Clin Microbiol Rev. 2007 Apr;20(2):243-67
17428885
Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10452-7
15235128
Emerg Infect Dis. 2008 Jun;14(6):958-61
18507914
J Virol. 2008 Apr;82(7):3405-14
18216109
Bioinformatics. 2001 Aug;17(8):754-5
11524383
J Virol. 2004 Aug;78(15):8372-81
15254209
Proc Natl Acad Sci U S A. 2004 May 25;101(21):8156-61
15148370
J Virol. 2007 Oct;81(19):10402-12
17652385
Emerg Infect Dis. 2008 Apr;14(4):632-6
18394281
Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9363-7
10430948
J Virol. 2002 Jan;76(1):118-26
11739677
Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8950-5
12077307
Nature. 2005 Jul 14;436(7048):191-2
16007072
Arch Virol. 2005 Jun;150(6):1257-66
15717120
Virology. 2006 Jul 5;350(2):258-68
16713612
Arch Virol. 2006 Aug;151(8):1615-24
16532371
N Engl J Med. 2006 Nov 23;355(21):2174-7
17124014
Emerg Infect Dis. 2006 Oct;12(10):1593-5
17176581
J Virol. 2007 Oct;81(19):10389-401
17652402
Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16936-41
17075062
Virology. 1995 Oct 20;213(1):223-30
7483266
J Virol. 2005 Dec;79(24):15460-6
16306617
Virology. 2000 Feb 15;267(2):279-88
10662623