title: Developing and testing adaptive treatment strategies using substance-induced psychosis as an example.
abstract: Decisions concerning treatment changes pervade the management of chronic psychiatric disorders that resist definitive cure, yet empirical evidence for the comparative clinical effectiveness of treatment strategies remains underdeveloped. In this paper we exploit the example of psychosis following substance use to illustrate some new developments in clinical trials design that can provide the most solid evidence base for defining successful strategies. The intent is to explore the strengths and limitations of the methodological approach through a meaningful clinical example, with an emphasis on concepts and issues. Both methodology and clinical science are overviewed.
authors.affiliation: Frontier Science & Technology Research Foundation, Boston, MA, USA. dawson@fstrf.dfci.harvard.edu
authors.forename: Ree
authors.initials: R
authors.lastname: Dawson
authors.forename: Alan I
authors.initials: AI
authors.lastname: Green
authors.forename: Robert E
authors.initials: RE
authors.lastname: Drake
authors.forename: Thomas H
authors.initials: TH
authors.lastname: McGlashan
authors.forename: Bella
authors.initials: B
authors.lastname: Schanzer
authors.forename: Philip W
authors.initials: PW
authors.lastname: Lavori
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use*; D006801:Humans; D055118:Medication Adherence; D011605:Psychoses, Substance-Induced / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic; D012107:Research Design
chemical_list: D014150:Antipsychotic Agents
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