[Synthesis of 1,3-dihydro-1,3-dioxo-2H-isoindole derivatives].
OBJECTIVE
To synthesize a series of derivatives of Thalidomide.


METHODS
The N-Phthaloyl-L-glutamic anhydride was ammonolyzed with amino acid benzyl esters, followed by hydrogenization. The reaction between the hydogenized products and ammonia gas produced ammonium salt, 1,3-dihydro-1,3-dioxo-2H-isoindole derivatives.


RESULTS
Four new derivatives of Thalidomide were obtained and confirmed by spectral detection.


CONCLUSIONS
The derivatives of Thalidomide can be efficiently synthesized under mild conditions.
Yang
Yue
Y
The Central Teaching Laboratory for Modern Pharmacy, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Xiang
Dong
D
Guo
Ju
J
Zheng
Yong-sheng
YS
Ye
Bin
B
Yang
Jin-liang
JL
Cheng
Li
L
D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D008956:Models, Chemical; D015394:Molecular Structure; D010797:Phthalimides / Q000138:chemical synthesis* / Q000737:chemistry; D013792:Thalidomide / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry
D020533:Angiogenesis Inhibitors; D010797:Phthalimides; D013792:Thalidomide