Hamster model of leptospirosis.
This unit describes the techniques involved in the hamster model of leptospirosis. Hamsters are exquisitely susceptible to infection with pathogenic Leptospira species. The LD(50) of virulent Leptospiral strains by intraperitoneal inoculation of 3- to 4-week-old hamsters is as low as a single organism. The pathogenesis of severe leptospirosis in the hamster is a model of accidental infections observed in nature in many mammals, including humans. Animal husbandry issues and the reproducibility of the hamster model make it the animal model of choice for Leptospiral vaccine and antibiotic treatment studies.
Haake
David A
DA
Veterans Affairs, Greater Los Angeles, Healthcare, Los Angeles, California, USA.
D000818:Animals; D006224:Cricetinae; D004195:Disease Models, Animal; D006801:Humans; D007919:Leptospira / Q000145:classification / Q000302:isolation & purification / Q000472:pathogenicity*; D007922:Leptospirosis / Q000382:microbiology / Q000473:pathology*; D008647:Mesocricetus; D014774:Virulence
J Hyg (Lond). 1962 Dec;60(4):435-42
20475861
Infect Immun. 1999 Dec;67(12):6572-82
10569777
J Infect Dis. 1961 Sep-Oct;109:194-204
14464840
Am J Pathol. 2004 Mar;164(3):1115-27
14982864
Am J Vet Res. 1957 Jan;18(66):35-42
13394814
Br J Exp Pathol. 1957 Feb;38(1):1-7
13413076
Curr Protoc Mol Biol. 2001 Nov;Chapter 2:Unit 2.4
18265184
Am J Vet Res. 1966 Jul;27(119):1071-81
5967328
Vet Microbiol. 1986 Nov;12(4):367-76
3538643
Vaccine. 2004 Mar 29;22(11-12):1545-52
15063580
Health Lab Sci. 1976 Apr;13(2):105-14
946794
Br J Exp Pathol. 1957 Feb;38(1):8-14
13457343
Curr Protoc Immunol. 2006 Jul;Chapter 1:1.3.1-1.3.6
18432962
Am Ind Hyg Assoc J. 1987 Mar;48(3):271-5
3578038
Curr Protoc Immunol. 2006 Jul;Chapter 1:1.7.1-1.7.9
18432965
Curr Protoc Mol Biol. 2001 May;Chapter 14:Unit 14.1
18265105
Curr Protoc Mol Biol. 2001 May;Chapter 14:Unit 14.5
18265113
Exp Toxicol Pathol. 1998 Jun;50(3):191-8
9681649
Am J Vet Res. 2001 Jul;62(7):995-1000
11453500
Antimicrob Agents Chemother. 2002 Mar;46(3):848-53
11850271
Curr Protoc Immunol. 2006 Jul;Chapter 1:1.6.1-1.6.10
18432964
BMC Infect Dis. 2002 Jul 08;2:13
12100734
Infect Immun. 1999 Feb;67(2):853-61
9916100