Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapy.
Patients with inefficient CD4+ T-cell recovery on virogically suppressive highly active antiretroviral therapy constitute a major clinical hurdle given the threat of HIV/AIDS disease progression. We show heightened circulating lipopolysaccharide associated with plasma enterobacterial DNA and highly activated Ki67+CD4+CD8+ in 24 immunologic-nonresponders (CD4+ T-cell < or = 200; HIV-RNA < or = 50) compared with 11 full responders (CD4+ T-cell > or= 400; HIV-RNA < or = 50). These data provide novel insight into INRs pathogenesis, since they correlate augmented systemic translocation of microbial bioproducts with T-cell hyperactivation.
Marchetti
Giulia
G
Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases, San Paolo Hospital, University of Milan, Milan, Italy. giulia.marchetti@unimi.it
Bellistrì
Giusi M
GM
Borghi
Elisa
E
Tincati
Camilla
C
Ferramosca
Stefania
S
La Francesca
Maria
M
Morace
Giulia
G
Gori
Andrea
A
Monforte
Antonella D'Arminio
AD
D000328:Adult; D000368:Aged; D023241:Antiretroviral Therapy, Highly Active; D018988:Bacterial Translocation / Q000276:immunology*; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D004269:DNA, Bacterial / Q000097:blood; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology* / Q000382:microbiology*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology; D008875:Middle Aged
D004269:DNA, Bacterial