Synthesis of pyrimidine analog of fluoroneplanocin A as potential anti-HCV agent.
N-hydroxycytosine nucleoside 3 was synthesized as potential anti-HCV agent, starting from D-ribose using an iodine-fluorine exchange reaction by a help of BuLi, a RCM reaction, a stereoselective reduction and a Mitsunobu reaction as the key steps.
Lee
Hyung-Rock
HR
College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan 609-735, Korea.
Kim
Won Hee
WH
Park
Ah-Young
AY
Kang
Jin-Ah
JA
Chun
Pusoon
P
Bae
Jang Ho
JH
Jeong
Lak Shin
LS
Moon
Hyung Ryong
HR
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry; D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000737:chemistry; D016174:Hepacivirus / Q000187:drug effects; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry
D000998:Antiviral Agents; D003517:Cyclopentanes; D011741:Pyrimidine Nucleosides