title: [Efficacy and safety of budesonide inhalation suspension nebulization by mesh nebulizer in Japanese infants and young children with bronchial asthma in 12-week, randomised, open study].
abstract: OBJECTIVE
  This study evaluated the efficacy and safety of Budesonide Inhalation Suspension (BIS) nebulazation by mesh nebulizer in children ages 6 months to 4 years with moderate to severe persistent asthma.
  
  
  METHODS
  This 12-week, randomized, open study involved 30 asthmatic children. They were randomized 3 different nebulizer groups, Pari TurboBoy +LC Plus nebulizer, Pari eMotion and Omron MicroAir NE-22U. BIS administered 0.25 mg once daily (qd). Efficacy was assessed by daily card. Safety was assessed by adverse event, plasma cortisol and growth.
  
  
  RESULTS
  Baseline concentrations of plasma cortisol were significantly high in the group of Omron MicroAir NE-22U compared to other group. Plasma cortisol were decreased significantly at 4 weeks in Omron MicroAir NE-22U compared with baseline, but those in no subjects decreased under normal range. Asthma symptoms were improved significantly from baseline to 12-week.
  
  
  CONCLUSIONS
  This study demonstrate that usage of mesh nebulizer in BIS 0.25 mg qd is effective and safe in young asthmatic children.
authors.affiliation: Department of Pediatrics, Fukuoka National Hospital. tezuka@mfukuoka2.hosp.go.jp
authors.forename: Junichiro
authors.initials: J
authors.lastname: Tezuka
authors.forename: Chikako
authors.initials: C
authors.lastname: Motomura
authors.forename: Junko
authors.initials: J
authors.lastname: Ikei
authors.forename: Koji
authors.initials: K
authors.lastname: Ide
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Kando
authors.forename: Makiko
authors.initials: M
authors.lastname: Goto
authors.forename: Naohiko
authors.initials: N
authors.lastname: Taba
authors.forename: Daisuke
authors.initials: D
authors.lastname: Hayashi
authors.forename: Yoko
authors.initials: Y
authors.lastname: Murakami
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Moriyasu
authors.forename: Keiji
authors.initials: K
authors.lastname: Soebijanto
authors.forename: Rumiko
authors.initials: R
authors.lastname: Shibata
authors.forename: Kenji
authors.initials: K
authors.lastname: Okada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Okada
authors.forename: Sankei
authors.initials: S
authors.lastname: Nishima
mesh_terms: D000280:Administration, Inhalation; D001249:Asthma / Q000188:drug therapy*; D019819:Budesonide / Q000008:administration & dosage*; D002675:Child, Preschool; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007223:Infant; D008297:Male; D009330:Nebulizers and Vaporizers; D013535:Suspensions
chemical_list: D005938:Glucocorticoids; D013535:Suspensions; D019819:Budesonide