Local tumours induced in chickens by continuous cell lines of the JMV Marek's disease tumour transplant.
Marek's disease (MD) tumour cell lines RPL-1 and JMV-1 were shown to express high oncogenic potential if inoculated intramuscularly. No more than 10(3) cells per dose were needed to cause primary tumours at the site of inoculation in 50% of 2-day-old chickens, but more than JO(6) to more than 10(7) cells were required to cause a 50% mortality due to lymphoblastic leukaemia as another parameter of oncogenicity. Herpesvirus of turkeys (HVT) was nonprotective against local tumour development of the transplants, and resistance to JMV tumours did not coincide with resistance to Marek's disease.
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Federal Research Institute for Animal Virus Diseases, Tubingen, West Germany.