DC migration: hard-wired for T cell activation.
Dendritic cells (DCs) play a central role in responding to pathogens. In this issue of Immunity, Aoshi et al. (2008) highlight the fact that the migratory route DCs take to drive T cell activation is independent of the architecture of lymphoid tissues.
Belz
Gabrielle T
GT
Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia.
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D002465:Cell Movement; D003713:Dendritic Cells / Q000276:immunology* / Q000502:physiology; D006801:Humans; D008213:Lymphocyte Activation