Regulating antibody diversity: taming a mutagen.
In a recent issue of Molecular Cell, Conticello et al. (2008) identified a protein that interacts with the activation-induced deaminase protein and affects somatic hypermutation, class switching, and gene conversion in immunoglobulin genes, possibly via the spliceosome transcription complex.
Gearhart
Patricia J
PJ
Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USA. gearhartp@grc.nia.nih.gov
Sen
Ranjan
R
D000916:Antibody Diversity / Q000235:genetics*; D051017:Apoptosis Regulatory Proteins / Q000235:genetics* / Q000276:immunology; D003564:Cytidine Deaminase / Q000235:genetics / Q000276:immunology*; D005785:Gene Conversion; D005803:Genes, Immunoglobulin; D006801:Humans; D017578:Immunoglobulin Class Switching / Q000235:genetics*; D007143:Immunoglobulin Heavy Chains / Q000235:genetics / Q000276:immunology; D007135:Immunoglobulin Variable Region / Q000235:genetics / Q000276:immunology; D009687:Nuclear Proteins / Q000235:genetics* / Q000276:immunology; D027041:Somatic Hypermutation, Immunoglobulin; D014158:Transcription, Genetic; D000098830:AICDA (Activation-Induced Cytidine Deaminase)
D051017:Apoptosis Regulatory Proteins; C479429:CTNNBL1 protein, human; D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region; D009687:Nuclear Proteins; D000098830:AICDA (Activation-Induced Cytidine Deaminase); D003564:Cytidine Deaminase