[Effect of simvastatin on the reserve of heart function and endothelial function in X-syndrome].
OBJECTIVE
To determine the therapeutic effect of simvastatin combined with traditional medicine on patients with X-syndrome, and on the reserve of heart function and endothelial function.


METHODS
Forty patients with X-syndrome were recruited from September 2006 to September 2007 and randomly divided into 2 groups (a simvastatin group and a control group). The control group received routine treatment including beta receptor blocker, calcium-channel blocker (CCB) and long active nitrate. The simvastatin group received simvastatin and the routine treatment. The clinical condition and exercise test (TET) were performed before and after the treatment.The levels of triglyeride (TG), total cholesterol (TC), low density lipoprotein (LDL-C), high density lipoprotein (HDL-C), endothelin-1 (ET-1) and nitric oxide (NO) were measured.


RESULTS
The frequencies of chest pain in the simvastatin group were lower than those in the control group. The levels of ET-1, ET-1/NO, TG, TC, and LDL-C were significantly decreased in the simvastatin group as compared with the control group after the treatment. The levels of HDL-C and NO were significantly increased in the simvastatin group as compared with the control group after the treatment. The time in TET was significantly increased in the simvastatin group as compared with the control group. The frequencies of chest pain were positively related to the level of ET-1/NO and negatively related to the time in TET.


CONCLUSIONS
Simvastatin is effective for patients with X-syndrome and may improve the endothelial function and the reserve of heart function.
Xie
Xiong-wei
XW
Department of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha 410008, China. xie_xiongwei@tom.com
Zhuang
Han-ping
HP
Tang
Feng-ying
FY
Yao
Jia-mei
JM
D000924:Anticholesteremic Agents / Q000627:therapeutic use; D008076:Cholesterol, HDL / Q000097:blood; D019332:Endothelin-1 / Q000097:blood*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D017566:Microvascular Angina / Q000188:drug therapy* / Q000503:physiopathology*; D009569:Nitric Oxide / Q000097:blood; D019821:Simvastatin / Q000627:therapeutic use*
D000924:Anticholesteremic Agents; D008076:Cholesterol, HDL; D019332:Endothelin-1; D009569:Nitric Oxide; D019821:Simvastatin