Expression of neurotrophin receptors by proliferating glia in postischemic hippocampal CA1 sector of adult monkeys.
Transient global cerebral ischemia elicits a nearly total neuronal cell death in the hippocampal CA1 sector, accompanied by a marked microglial and astroglial proliferation. The molecular mechanisms regulating the postischemic glial reaction in the primate brain remain obscure. Here we present in situ evidence that proliferating postischemic microglia in adult monkey CA1 sector express the neurotrophin receptor TrkA, while activated astrocytes were labeled for the TrkA ligand nerve growth factor (NGF) and the tyrosine kinase TrkB, a receptor for brain-derived neurotrophic factor (BDNF). These results implicate NGF and BDNF as regulators of postischemic glial proliferation in adult primate hippocampus.
Tonchev
Anton B
AB
Department of Restorative Neurosurgery, Division of Neuroscience, Kanazawa University Graduate School of Medical Science, Takara-machi 13-1, Kanazawa, 920-8641 Japan.
Boneva
Nadezhda B
NB
Kaplamadzhiev
Desislav B
DB
Kikuchi
Mitsuru
M
Mori
Yoshimi
Y
Sahara
Shunya
S
Yamashima
Tetsumori
T
D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D002545:Brain Ischemia / Q000473:pathology*; D001973:Bromodeoxyuridine / Q000378:metabolism; D049109:Cell Proliferation; D015870:Gene Expression / Q000502:physiology*; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology*; D008252:Macaca fascicularis; D009414:Nerve Growth Factors / Q000235:genetics / Q000378:metabolism; D009457:Neuroglia / Q000378:metabolism* / Q000473:pathology; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D017475:Receptors, Nerve Growth Factor / Q000235:genetics / Q000378:metabolism*; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D001973:Bromodeoxyuridine; D009414:Nerve Growth Factors; D010751:Phosphopyruvate Hydratase; D017475:Receptors, Nerve Growth Factor; C067980:CD68 antigen, human; D000097382:CD68 Molecule