title: Reverse engineering models of cell cycle regulation.
abstract: From general considerations of the basic physiological properties of the cell division cycle, we deduce what the dynamical properties of the underlying molecular control system must be. Then, taking a few hints from the biochemistry of cyclin-dependent kinases (the master regulators of the eukaryotic cell cycle), we guess what molecular mechanisms must be operating to produce the desired dynamical properties of the control system.
authors.affiliation: Materials Structure and Modeling Research Group of the Hungarian Academy of Sciences, Budapest, Hungary. csikasz@mail.bme.hu
authors.forename: Attila
authors.initials: A
authors.lastname: Csikász-Nagy
authors.forename: Béla
authors.initials: B
authors.lastname: Novák
authors.forename: John J
authors.initials: JJ
authors.lastname: Tyson
mesh_terms: D001683:Biological Clocks; D001698:Biomedical Engineering; D002453:Cell Cycle / Q000502:physiology*; D053858:Metabolic Networks and Pathways; D008954:Models, Biological; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000502:physiology