Efficacy of sub-Tenon's capsule injection of triamcinolone acetonide for refractory diabetic macular edema after vitrectomy.
OBJECTIVE
To determine whether or not a sub-Tenon's capsule injection of triamcinolone acetonide(TA) is an effective treatment for refractory diabetic macular edema after vitrectomy.


METHODS
Thirty-nine eyes of 26 patients with diabetic macular edema were injected with 20 mg TA into the sub-Tenon's capsule. The central macular thickness (CMT) measured by an optical coherence tomography (OCT) and visual acuities were compared between pre-treatment and 1, 3 months post-treatment.


RESULTS
The decrease in the mean CMT between the baseline (435 microm) and 1 month (326 microm) or 3 months (303 microm) time points was statistically significant. Seven eyes (70%) at 1 month and 3 months post-treatment in the vitrectomized eyes or PPV(pars plana vitrectomy)(+) group, 15 eyes(52%) at 1 month, and 19 eyes (66%) at 3 months in the non-vitrectomized eyes or PPV(-)group maintained 20% reduction in CMT from pre-treatment with a single injection of TA. The recurrence of macular edema was observed in 1 eye (14%) in the PPV(+)group, and 3 eyes (16%) in the PPV(-)group.


CONCLUSIONS
The sub-Tenon's capsule injection of TA was effective for refractory diabetic macular edema after vitrectomy. In addition, it was suggested that the treatment of vitrectomized eyes was more effective than that of non-vitrectomized eyes.
Sato
Hiroyuki
H
Department of Ophthalmology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan.
Naito
Takeshi
T
Matsushita
Shingo
S
Takebayashi
Masaru
M
Shiota
Hiroshi
H
D000368:Aged; D003228:Conjunctiva; D003930:Diabetic Retinopathy / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D008269:Macular Edema / Q000150:complications* / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D014222:Triamcinolone Acetonide / Q000008:administration & dosage*; D014792:Visual Acuity; D014821:Vitrectomy
D005938:Glucocorticoids; D014222:Triamcinolone Acetonide