Synthesis and biological evaluation of alkoxycoumarins as novel nematicidal constituents.
We synthesized all of the monomethoxycoumarins, 5-alkoxycoumarins and their derivatives, and investigated their nematicidal activity against the phytopathogenic nematode, Bursaphelenchus xylophilus. Among the compounds, 5-ethoxycoumarin showed the highest nematicidal activity. Furthermore, 5-ethoxycoumarin was comparatively harmless against both the brine shrimps, Artemia salina, and the Japanese killifish, Oryzias latipes.
Takaishi
Kazuto
K
Laboratory of Applied Natural Products Chemistry, The Graduate School of Natural Science and Technology, Okayama University, 1-1-1 Tsushimanaka, Okayama, Okayama 700-8530, Japan. ktakaishi@riken.jp
Izumi
Minoru
M
Baba
Naomichi
N
Kawazu
Kazuyoshi
K
Nakajima
Shuhei
S
D000818:Animals; D000969:Antinematodal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001156:Artemia; D001681:Biological Assay; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D006868:Hydrolysis; D008956:Models, Chemical; D009348:Nematoda; D009990:Oryzias; D013329:Structure-Activity Relationship
D000969:Antinematodal Agents; D003374:Coumarins; C030123:coumarin