Treatment of diffuse large B-cell lymphoma of the liver with yttrium-90 microsphere embolization.
BACKGROUND
A 41-year-old male with a 4-year history of chronic hepatitis C presented with a 1-month history of abdominal pain, fatigue, weight loss, and night sweats.


METHODS
Laboratory examinations, chest, abdomen, and pelvic CT scans, PET-CT scans, ultrasound-guided needle biopsies of liver lesions, bone-marrow biopsy, flow cytometry, and immunohistochemical staining for B-cell markers including CD20.


METHODS
Chemoresistant diffuse large B-cell lymphoma, with gradual loss of CD20 antigen expression.


RESULTS
Embolization of hepatic tumors using yttrium-90 microspheres (Therasphere, Theragenics Corporation, Buford, GA).
Fenske
Timothy S
TS
Division of Neoplastic Diseases and Related Disorders, Medical College of Wisconsin, Milwaukee, WI 53226, USA. tfenske@mcw.edu
Benjamin
Heather
H
Kroft
Steven H
SH
Hohenwalter
Eric J
EJ
Rilling
William S
WS
D000328:Adult; D018951:Antigens, CD20 / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy / Q000379:methods; D003937:Diagnosis, Differential; D004621:Embolization, Therapeutic / Q000379:methods*; D017809:Fatal Outcome; D006801:Humans; D008113:Liver Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000532:radiotherapy*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000737:chemistry / Q000175:diagnosis* / Q000532:radiotherapy*; D008297:Male; D008863:Microspheres; D010166:Palliative Care; D015021:Yttrium Radioisotopes / Q000008:administration & dosage*
D018951:Antigens, CD20; D014408:Biomarkers, Tumor; D015021:Yttrium Radioisotopes