Antiplaque/antigingivitis efficacy and safety of a cetylpyridinium chloride/zinc gluconate mucoadhesive gel. Results of a 6-month clinical trial.
This article presents the results of a controlled clinical trial evaluating a new at-home treatment to improve gingival health. Designed for overnight application at the gingival margins and in the interproximal spaces, the product is a mucoadhesive gel containing 0.10% cetylpyridinium chloride (CPC) and 0.592% zinc gluconate (ZG). The authors assessed the efficacy and safety of the CPC/ZG gel in adults with low-to-moderate gingival and plaque index scores by comparing clinical and laboratory findings for subjects using the CPC/ZG gel with those for subjects using the control gel (0% CPC and 0.592% ZG). Clinical findings at 3 and 6 months showed statistically significant improvements in two of the three major indices of gingival health in the CPC/ZG group compared with the control group. The performance of the treatment gel was supported by results of microbial analyses of plaque samples.
Lee
Sean S
SS
Center for Dental Research, Loma Linda University School of Dentistry, Loma Linda, California, USA.
Aprecio
Raydolfo M
RM
Zhang
Wu
W
Arambula
Michele
M
Wilkins
Kristi B
KB
Stephens
Joni A
JA
Kim
Jay S
JS
Li
Yiming
Y
D000328:Adult; D000368:Aged; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000627:therapeutic use*; D002594:Cetylpyridinium / Q000008:administration & dosage / Q000627:therapeutic use*; D003773:Dental Plaque / Q000382:microbiology / Q000517:prevention & control*; D003774:Dental Plaque Index; D005260:Female; D005500:Follow-Up Studies; D005782:Gels; D005884:Gingival Hemorrhage / Q000517:prevention & control; D005891:Gingivitis / Q000517:prevention & control*; D005942:Gluconates / Q000008:administration & dosage / Q000627:therapeutic use*; D006190:Haemophilus / Q000187:drug effects; D006801:Humans; D018020:Lithium Compounds / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D018713:Prevotella intermedia / Q000187:drug effects; D012449:Safety; D013295:Streptococcus mutans / Q000187:drug effects; D016896:Treatment Outcome; D015032:Zinc / Q000008:administration & dosage / Q000627:therapeutic use*
D000891:Anti-Infective Agents, Local; D005782:Gels; D005942:Gluconates; D018020:Lithium Compounds; D002594:Cetylpyridinium; D015032:Zinc; C030691:gluconic acid