title: Pharmacologic modulation of ACE2 expression.
abstract: Angiotensin-converting enzyme 2 (ACE2) is an enzymatically active homologue of angiotensin-converting enzyme that degrades angiotensin I, angiotensin II, and other peptides. Recent studies have shown that under pathologic conditions, ACE2 expression in the kidney is altered. In this review, we briefly summarize recent studies dealing with pharmacologic interventions that modulate ACE2 expression. ACE2 amplification may have a potential therapeutic role for kidney disease and hypertension.
authors.affiliation: Division of Nephrology and Hypertension, Department of Medicine, Feinberg School of Medicine, Northwestern University, 320 East Superior, Chicago, IL 60611, USA.
authors.forename: María José
authors.initials: MJ
authors.lastname: Soler
authors.forename: Clara
authors.initials: C
authors.lastname: Barrios
authors.forename: Raymond
authors.initials: R
authors.lastname: Oliva
authors.forename: Daniel
authors.initials: D
authors.lastname: Batlle
mesh_terms: D000803:Angiotensin I / Q000096:biosynthesis* / Q000187:drug effects; D000804:Angiotensin II / Q000096:biosynthesis* / Q000187:drug effects; D047228:Angiotensin II Type 1 Receptor Blockers / Q000627:therapeutic use; D000085962:Angiotensin-Converting Enzyme 2; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use; D018450:Disease Progression; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D007703:Peptidyl-Dipeptidase A / Q000096:biosynthesis* / Q000187:drug effects*; D044140:Receptor, Angiotensin, Type 1 / Q000187:drug effects; D012084:Renin-Angiotensin System / Q000187:drug effects
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D044140:Receptor, Angiotensin, Type 1; D000804:Angiotensin II; D000803:Angiotensin I; D007703:Peptidyl-Dipeptidase A; C000705307:ACE2 protein, human; D000085962:Angiotensin-Converting Enzyme 2
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