Xenotransplantation: benefits, risks and relevance of reproductive technology.
Xenotransplantation from pigs provides a possible way around the shortage of human organs for transplantation. The highly inbred Westran line of pigs is genetically well characterised and known to lack endogenous retroviruses able to infect human cells. Like most inbreds, it has poor reproductive performance for which reproductive interventions would be desirable.
Moran
C
C
Centre for Advanced Technologies in Animal Genetics and Reproduction, University of Sydney, NSW 2006, Australia. Chris.Moran@vetsci.usyd.edu.au
D000818:Animals; D006084:Graft Rejection; D006801:Humans; D007178:Inbreeding; D016377:Organ Transplantation; D012098:Reproduction / Q000235:genetics / Q000502:physiology*; D012190:Retroviridae; D012307:Risk Factors; D013552:Swine / Q000235:genetics* / Q000502:physiology; D014183:Transplantation, Heterologous / Q000009:adverse effects* / Q000662:veterinary