title: Prognostic factor of adult patients with atopic dermatitis.
abstract: The increased prevalence of atopic dermatitis (AD) in adults in recent decades suggests that dermatologists may be expected to estimate the prognosis of adult patients with AD when they visit as new patients. We therefore evaluated the change in the extent of involvement and analyzed the factors that contribute to the prognosis of adult AD. A retrospective chart review was performed for 65 adults patients (median age at first visit, 25 years) with AD who had been followed monthly for over 10 years. The median area of involvement at first visit was 19%. The area of the eruptions and peripheral eosinophil counts decreased significantly in the fifth and 10th years with standard treatment. The values of immunoglobulin (Ig)E were also reduced after 10 years. Patients with high values of serum total IgE and peripheral eosinophil count, and long duration of AD had wide areas of eruptions 10 years after the first visit. Total IgE had the highest correlation with area of involvement after 10 years. Although the prognosis of adult AD is not poor, patients with high IgE values are expected to have ongoing eczema with wide distribution after 10 years of follow up.
authors.affiliation: Department of Dermatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan. nkatoh@koto.kpu-m.ac.jp
authors.forename: Norito
authors.initials: N
authors.lastname: Katoh
authors.forename: Shinya
authors.initials: S
authors.lastname: Hirano
authors.forename: Saburo
authors.initials: S
authors.lastname: Kishimoto
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D003876:Dermatitis, Atopic / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D004804:Eosinophils; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D009824:Ointments; D011239:Prednisolone / Q000008:administration & dosage; D011379:Prognosis; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D015415:Biomarkers; D005938:Glucocorticoids; D009824:Ointments; D007073:Immunoglobulin E; D011239:Prednisolone; D007770:L-Lactate Dehydrogenase