title: Synthetic biology for improved personalized medicine.
abstract: Tools to re-sequence the genomes of individual patients having well described medical histories is the first step required to connect genetic information to diagnosis, prognosis, and treatment. There is little doubt that in the future, genomics will influence the choice of therapies for individual patients based on their specific genetic inheritance, as well as the genetic defects that led to disease. Cost is the principle obstacle preventing the realization of this vision. Unless the interesting parts of a patient genome can be resequenced for less than $10,000 (as opposed to $100,000 or more), it will be difficult to start the discovery process that will enable this vision. While instrumentation and biology are important to reducing costs, the key element to cost-effective personalized genomic sequencing will be new chemical reagents that deliver capabilities that are not available from standard DNA. Scientists at the Foundation for Applied Molecular Evolution and the Westheimer Institute have developed several of these, which will be the topic of this talk..
authors.affiliation: Foundation for Applied Molecular Evolution, 1115 NW 4 Street, Gainesville, FL 32601, USA. sbenner@ffame.org
authors.forename: Steven A
authors.initials: SA
authors.lastname: Benner
authors.forename: Shuichi
authors.initials: S
authors.lastname: Hoshika
authors.forename: Makoto
authors.initials: M
authors.lastname: Sukeda
authors.forename: Daniel
authors.initials: D
authors.lastname: Hutter
authors.forename: Nicole
authors.initials: N
authors.lastname: Leal
authors.forename: Zunyi
authors.initials: Z
authors.lastname: Yang
authors.forename: Fei
authors.initials: F
authors.lastname: Chen
mesh_terms: D020029:Base Pairing; D020650:Combinatorial Chemistry Techniques; D030342:Genetic Diseases, Inborn / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D015894:Genome, Human; D023281:Genomics / Q000191:economics; D005838:Genotype; D006801:Humans; D007202:Indicators and Reagents / Q000737:chemistry
chemical_list: D007202:Indicators and Reagents