Differential requirements of a mitotic acetyltransferase in somatic and germ line cells.
During mitosis different types of cells can have differential requirements for chromosome segregation. We isolated two new alleles of the separation anxiety gene (san). san was previously described in both Drosophila and in humans to be required for centromeric sister chromatid cohesion (Hou et al., 2007; Williams et al., 2003). Our work confirms and expands the observation that san is required in vivo for normal mitosis of different types of somatic cells. In addition, we suggest that san is also important for the correct resolution of chromosomes, implying a more general function of this acetyltransferase. Surprisingly, during oogenesis we cannot detect mitotic defects in germ line cells mutant for san. We hypothesize the female germ line stem cells have differential requirements for mitotic sister chromatid cohesion.
Pimenta-Marques
Ana
A
Instituto Gulbenkian de Ciência, Rua da Quinta Grande, n 6, 2781-901 Oeiras, Portugal.
Tostões
Rui
R
Marty
Thomas
T
Barbosa
Vítor
V
Lehmann
Ruth
R
Martinho
Rui Gonçalo
RG
D000123:Acetyltransferases / Q000378:metabolism*; D000483:Alleles; D000818:Animals; D001756:Blastoderm / Q000166:cytology / Q000201:enzymology; D020090:Chromosome Segregation; D002875:Chromosomes / Q000201:enzymology; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000166:cytology* / Q000196:embryology / Q000201:enzymology* / Q000235:genetics; D017344:Genes, Insect; D005854:Germ Cells / Q000166:cytology* / Q000201:enzymology*; D007814:Larva / Q000166:cytology / Q000201:enzymology; D008938:Mitosis; D009474:Neurons / Q000166:cytology / Q000201:enzymology; D009866:Oogenesis; D012854:Sister Chromatid Exchange; D015053:Zygote / Q000166:cytology / Q000201:enzymology
D029721:Drosophila Proteins; D000123:Acetyltransferases; C533244:San protein, Drosophila
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