title: Plasma and milk kinetic of eprinomectin and moxidectin in lactating water buffaloes (Bubalus bubalis).
abstract: The pharmacokinetics and mammary excretion of moxidectin and eprinomectin were determined in water buffaloes (Bubalus bubalis) following topical administration of 0.5mgkg(-1). Following administration of moxidectin, plasma and milk concentrations of moxidectin increased to reach maximal concentrations (C(max)) of 5.46+/-3.50 and 23.76+/-16.63ngml(-1) at T(max) of 1.20+/-0.33 and 1.87+/-0.77 days in plasma and milk, respectively. The mean residence time (MRT) were similar for plasma and milk (5.27+/-0.45 and 5.87+/-0.80 days, respectively). The AUC value was 5-fold higher in milk (109.68+/-65.01ngdayml(-1)) than in plasma (23.66+/-12.26ngdayml(-1)). The ratio of AUC milk/plasma for moxidectin was 5.04+/-2.13. The moxidectin systemic availability (expressed as plasma AUC values) obtained in buffaloes was in the same range than those reported in cattle. The faster absorption and elimination processes of moxidectin were probably due to a lower storage in fat associated with the fact that animals were in lactation. Nevertheless, due to its high excretion in milk and its high detected maximum concentration in milk which is equivalent or higher to the Maximal Residue Level value (MRL) (40ngml(-1)), its use should be prohibited in lactating buffaloes. Concerning eprinomectin, the C(max) were of 2.74+/-0.89 and 3.40+/-1.68ngml(-1) at T(max) of 1.44+/-0.20 and 1.33+/-0.0.41 days in plasma and milk, respectively. The MRT and the AUC were similar for plasma (3.17+/-0.41 days and 11.43+/-4.01ngdayml(-1)) and milk (2.70+/-0.44 days and 8.49+/-3.33ngdayml(-1)). The ratio of AUC milk/plasma for eprinomectin was 0.76+/-0.16. The AUC value is 20 times lower than that reported in dairy cattle. The very low extent of mammary excretion and the milk levels reported lower than the MRL (20ngml(-1)) supports the permitted use of eprinomectin in lactating water buffaloes.
authors.affiliation: INRA-UR66, Laboratoire de Pharmacologie-Toxicologie, B.P. 3, 31931 Toulouse Cedex 9, France. Jacques.Dupuy@toulouse.inra.fr
authors.forename: Jacques
authors.initials: J
authors.lastname: Dupuy
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Sutra
authors.forename: Michel
authors.initials: M
authors.lastname: Alvinerie
authors.forename: Laura
authors.initials: L
authors.lastname: Rinaldi
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Veneziano
authors.forename: Laura
authors.initials: L
authors.lastname: Mezzino
authors.forename: Saverio
authors.initials: S
authors.lastname: Pennacchio
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Cringoli
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000871:Anthelmintics / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002020:Buffaloes / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D007559:Ivermectin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics; D007774:Lactation; D018942:Macrolides / Q000008:administration & dosage / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics; D008892:Milk / Q000737:chemistry*
chemical_list: D000871:Anthelmintics; D018942:Macrolides; D007559:Ivermectin; C101434:eprinomectin; C027837:moxidectin