Islet transplantation: the quest for an ideal source.
The progress of islet transplantation as a new therapy for patients with diabetes mellitus depends directly upon the development of efficient and practical immunoisolation methods for the supply of sufficient quantities of islet cells. Without these methods, large scale clinical application of this therapy would be impossible. Two eras of advances can be identified in the development of islet transplantation. The first was an era of experimental animal and human research that centered on islet isolation procedures and transplantation in different species as evidence that transplanted islets have the capability to reverse diabetes. The second was the era of the Edmonton protocol, when the focus became the standardization of isolation procedures and introduction of new immunosuppressive drugs to maintain human allograft transplantation. The quest for an alternative source for islets (xenographs, stem cells and cell cultures) to overcome the shortage of human islets was an important issue during these eras. This paper reviews the history of islet transplantation and the current procedures in human allotransplantation, as well as different types of immunoisolation methods. It explores novel approaches to enhancing transplantation site vascularity and islet cell function, whereby future immunoisolation technology could offer additional therapeutic advantages to human islet allotransplantation.
Younes
Nidal A
NA
Department of Surgery, University of Jordan, Amman, Jordan. niyounes@ju.edu.jo
Nothias
Jean-Manuel
JM
Garfinkel
Marc R
MR
D000818:Animals; D002478:Cells, Cultured; D003920:Diabetes Mellitus / Q000628:therapy*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D016381:Islets of Langerhans Transplantation / Q000266:history / Q000276:immunology*; D013234:Stem Cells / Q000378:metabolism; D014183:Transplantation, Heterologous / Q000379:methods; D014184:Transplantation, Homologous / Q000379:methods
Diabetes Obes Metab. 2006 Jan;8(1):15-25
16367878
Diabetes. 2004 Apr;53(4):955-62
15047610
N Engl J Med. 2006 Sep 28;355(13):1318-30
17005949
Transplant Proc. 2001 Feb-Mar;33(1-2):1711-2
11267481
N Engl J Med. 2000 Jul 27;343(4):230-8
10911004
Lancet. 1993 Jan 2;341(8836):19-21
8093268
Am J Transplant. 2004 Jul;4(7):1051-60
15196061
J Virol. 1998 Apr;72(4):3082-7
9525633
Expert Opin Biol Ther. 2001 Jan;1(1):109-19
11727540
Lancet. 1998 Aug 29;352(9129):695-9
9728986
Transplantation. 2002 Dec 27;74(12):1809-11
12499905
Nutr Clin Pract. 2004 Apr;19(2):154-64
16215103
Transplant Proc. 2005 Jan-Feb;37(1):229-30
15808603
Diabetes Technol Ther. 2003;5(4):653-63
14511420
Transplantation. 2002 Dec 27;74(12):1813-6
12499907
Adv Drug Deliv Rev. 2000 Aug 20;42(1-2):29-64
10942814
Diabetes. 1967 Jan;16(1):35-9
5333500
Diabetes. 1990 Apr;39(4):519-22
2108072
Transplantation. 1991 Mar;51(3):651-5
2006522
Nat Med. 1997 Mar;3(3):282-6
9055854
Transplantation. 2003 Jul 15;76(1):199-203
12865810
Transplant Proc. 2002 May;34(3):826-7
12034198
J Biomed Mater Res. 1988 Nov;22(11):1061-70
3071539
Biotechnol Bioeng. 1998 Mar 20;57(6):655-65
10099245
Small. 2007 Apr;3(4):683-90
17340661
Science. 1980 Nov 21;210(4472):908-10
6776628
Diabetes. 2003 Jul;52(7):1595-603
12829621
Acta Diabetol. 1993;30(4):181-9
8180410
Transplant Proc. 1996 Dec;28(6):3516-7
8962367
Curr Diab Rep. 2002 Aug;2(4):365-70
12643197
Curr Gene Ther. 2005 Apr;5(2):249-62
15853732
Dev Growth Differ. 2006 Jun;48(5):323-32
16759282
Transplantation. 1995 Apr 15;59(7):1060-3
7709446
Diabetologia. 2002 Feb;45(2):159-73
11935147
Science. 2001 Apr 13;292(5515):265-7
11303097
Acta Diabetol. 1993;30(2):93-8
8219265
Diabetologia. 1997 Mar;40(3):262-70
9084963
Lancet. 1994 Apr 16;343(8903):950-1
7909011
J Hepatobiliary Pancreat Surg. 2000;7(4):374-9
11180858
Mol Genet Metab. 2001 Sep-Oct;74(1-2):200-5
11592816
Transplantation. 1993 Apr;55(4):713-7; discussion 717-8
8475540
Cell Transplant. 2000 Nov-Dec;9(6):895-901
11202575
Diabetes. 2005 Jul;54(7):2060-9
15983207
Diabetes. 1997 Jul;46(7):1120-3
9200645
Transplantation. 1996 Oct 15;62(7):893-9
8878380
Diabetes. 1988 Apr;37(4):413-20
3288530
Expert Opin Biol Ther. 2003 Apr;3(2):201-5
12662135
Methods Mol Biol. 2006;333:47-104
16790847
Int J Artif Organs. 1993 Apr;16(4):205-12
8325698
J Artif Organs. 2004;7(1):1-8
15083337
Surgery. 1972 Aug;72(2):175-86
4262169
Cell Transplant. 2005;14(10):757-62
16454350
Diabetes. 1999 Jul;48(7):1381-8
10389842
Transplantation. 1996 Apr 15;61(7):1047-53
8623183
Transplant Proc. 2001 Feb-Mar;33(1-2):1713-4
11267482
Int J Biochem Cell Biol. 2004 Apr;36(4):667-83
15010331
Diabetes. 2002 Jul;51(7):2148-57
12086945
Cell Transplant. 1995 Jul-Aug;4(4):415-36
7582573
Diabetes. 2005 Dec;54(12):3387-94
16306353
Nature. 1973 Aug 17;244(5416):447
4200461
Cell Transplant. 1999 May-Jun;8(3):285-92
10442741
Transplantation. 2002 Oct 15;74(7):913-5
12394830
Diabetes. 1989 Jan;38 Suppl 1:192-5
2492004
J Appl Biomater. 1991 Winter;3(4):281-6
10147997
Diabetes. 1989 Jan;38 Suppl 1:224-5
2492009
Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5843-7
8516335
Diabetes. 1994 Sep;43(9):1167-70
8070618
Diabetes. 1992 Dec;41(12):1503-10
1446791
Transplantation. 1994 Apr 15;57(7):1010-7
8165696
Transplant Proc. 2005 Oct;37(8):3505-8
16298643
Transplant Proc. 2006 May;38(4):1156-7
16757293
Pancreas. 2005 Aug;31(2):108-18
16024996
Biotechnol Bioeng. 1993 Jul;42(3):381-6
18613023
Diabetes. 1992 Jul;41(7):886-9
1612204
Diabetes Technol Ther. 2005 Dec;7(6):968-85
16386103
J Biomater Sci Polym Ed. 1994;6(4):313-23
7841141
Cell Transplant. 1999 May-Jun;8(3):293-306
10442742
Diabetes. 1977 Dec;26(12):1136-9
412720