title: Incorporation of 3'-S-phosphorothiolates into RNA: potential applications in RNAi.
abstract: Using solid-phase synthesis, oligoribonucleotides containing multiple 3'-S-phosphorothiolate modifications have been successfully synthesized, purified and characterized, utilizing a 2'-deoxyuridine phosphorothioamidite monomer.
authors.affiliation: Department of Chemistry, University of Liverpool, Crown Street, Liverpool, L69 7ZD, UK. jwgaynor@liv.ac.uk
authors.forename: James
authors.initials: J
authors.lastname: Gaynor
authors.forename: Julie
authors.initials: J
authors.lastname: Fisher
authors.forename: Barry
authors.initials: B
authors.lastname: Campbell
authors.forename: Richard
authors.initials: R
authors.lastname: Cosstick
mesh_terms: D009843:Oligoribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D010710:Phosphates / Q000737:chemistry*; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000138:chemical synthesis* / Q000737:chemistry; D013873:Thionucleotides / Q000138:chemical synthesis / Q000737:chemistry; D013891:Thiouridine / Q000737:chemistry*; D051996:Transcription Factor RelA / Q000037:antagonists & inhibitors
chemical_list: C465503:3'-S-phosphorothiolate; D009843:Oligoribonucleotides; D010710:Phosphates; D034741:RNA, Small Interfering; D013873:Thionucleotides; D051996:Transcription Factor RelA; D013891:Thiouridine