The effects of cholinergic neuromodulation on neuronal phase-response curves of modeled cortical neurons.
The response of an oscillator to perturbations is described by its phase-response curve (PRC), which is related to the type of bifurcation leading from rest to tonic spiking. In a recent experimental study, we have shown that the type of PRC in cortical pyramidal neurons can be switched by cholinergic neuromodulation from type II (biphasic) to type I (monophasic). We explored how intrinsic mechanisms affected by acetylcholine influence the PRC using three different types of neuronal models: a theta neuron, single-compartment neurons and a multi-compartment neuron. In all of these models a decrease in the amount of a spike-frequency adaptation current was a necessary and sufficient condition for the shape of the PRC to change from biphasic (type II) to purely positive (type I).
Stiefel
Klaus M
KM
Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. stiefel@salk.edu
Gutkin
Boris S
BS
Sejnowski
Terrence J
TJ
D000109:Acetylcholine / Q000378:metabolism*; D000465:Algorithms; D002540:Cerebral Cortex / Q000166:cytology / Q000502:physiology*; D003198:Computer Simulation; D008564:Membrane Potentials; D008959:Models, Neurological; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D012984:Software; D013569:Synapses / Q000502:physiology; D009435:Synaptic Transmission
D000109:Acetylcholine
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