title: Anti-inflammatory, anti-angiogenic and anti-nociceptive activities of Saururus chinensis extract.
abstract: ETHNOPHARMACOLGICAL RELEVANCE: The aerial parts of Saururus chinensis Baill. are used for the treatment of edema and inflammatory diseases in the Oriental folk medicine.
  
  
  OBJECTIVE
  This study aimed to elucidate anti-inflammatory and related activities of the ethanol extract (SC) of the dried aerial parts of Saururus chinensis Baill.
  
  
  METHODS
  Anti-angiogenic and anti-nociceptive activities of SC were analyzed using the chick chorioallantoic membrane (CAM) assay and acetic acid-induced writhing response, respectively. Anti-inflammatory activity of SC was evaluated using acetic acid-induced vascular permeability, carrageenan-induced air pouch formation and analyses of nitrite content and induced nitric oxide synthase (iNOS) level in the macrophage cells.
  
  
  RESULTS
  SC dose-dependently displayed a strong inhibition in the CAM angiogenesis. SC showed significant anti-nociceptive activity in the writhing model. The anti-inflammatory activity of SC was also assessed in the two in vivo models, such as vascular permeability and air pouch models in mice. SC suppressed production of nitric oxide and induction of iNOS and cyclooxygenase-2 in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages.
  
  
  CONCLUSIONS
  The aerial parts of Saururus chinensis possess potent anti-angiogenic and anti-nociceptive activities in addition to anti-inflammatory activity, which partly supports its therapeutic efficacy.
authors.affiliation: College of Pharmacy, Sookmyung Women's University, Cheongpa-dong, Yonsan-ku, Seoul 140-742, Republic of Korea.
authors.forename: Hye-Jung
authors.initials: HJ
authors.lastname: Yoo
authors.forename: Hyun-Jung
authors.initials: HJ
authors.lastname: Kang
authors.forename: Hyun-Joo
authors.initials: HJ
authors.lastname: Jung
authors.forename: Kyunghoon
authors.initials: K
authors.lastname: Kim
authors.forename: Chang-Jin
authors.initials: CJ
authors.lastname: Lim
authors.forename: Eun-Hee
authors.initials: EH
authors.lastname: Park
mesh_terms: D000700:Analgesics / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology; D020533:Angiogenesis Inhibitors / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D002642:Chick Embryo; D049033:Chorioallantoic Membrane / Q000187:drug effects / Q000378:metabolism; D051546:Cyclooxygenase 2 / Q000187:drug effects / Q000378:metabolism; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D007249:Inflammation / Q000188:drug therapy; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008518:Medicine, East Asian Traditional; D051379:Mice; D008813:Mice, Inbred ICR; D009569:Nitric Oxide / Q000378:metabolism; D010146:Pain / Q000188:drug therapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D032134:Saururaceae / Q000737:chemistry*
chemical_list: D000700:Analgesics; D020533:Angiogenesis Inhibitors; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D009569:Nitric Oxide; D051546:Cyclooxygenase 2