[Beta2 glycoprotein-I--the main antigen in antiphospholipid syndrome].
The term "antiphospholipid antibodies" describing a laboratory hallmark of antiphospholipid syndrome (APS) is a misnomer. It suggests that antibodies are directed against phospholipids. Meanwhile the specific antigens are in fact proteins demonstrating an affinity to phospholipids. In APS antibodies directed against a serum protein, beta2 glycoprotein-I, play most probably a pathogenic role and are strongly associated with clinical symptoms of the syndrome. Putative mechanisms of action of anti-beta2 glycoprotein-I antibodies are discussed.
Musiał
Jacek
J
II Katedra Chorób Wewnetrznych, Collegium Medicum Uniwersytetu Jagiellońskiego, Kraków. mmmusia@cyf-kr.edu.pl
D017152:Antibodies, Antiphospholipid / Q000276:immunology*; D016736:Antiphospholipid Syndrome / Q000276:immunology* / Q000503:physiopathology*; D006801:Humans; D007674:Kidney Diseases / Q000276:immunology / Q000503:physiopathology; D053482:beta 2-Glycoprotein I / Q000276:immunology*
D017152:Antibodies, Antiphospholipid; D053482:beta 2-Glycoprotein I