title: Cardiac dual-source computed tomography: effect of body mass index on image quality and diagnostic accuracy.
abstract: OBJECTIVE
  The aim of our study was to assess the impact of body mass index (BMI) on image quality and diagnostic accuracy using dual-source computed tomography.
  
  
  METHODS
  Dual-source computed tomography and invasive coronary angiography were performed in 125 consecutive patients. Coronary segments were assessed for both image quality (1: excellent; 4: poor) and presence of significant vessel stenosis (>or=50%). Accuracy of lesion detection was calculated using invasive coronary angiography as the standard of reference. The impact of BMI on image quality and accuracy was assessed by multivariate regression and between subgroups of BMI.
  
  
  RESULTS
  Mean BMI in our study was 28.4 +/- 4.1 kg/m2. In multivariate regression, BMI was proved to have a significant and independent impact on image quality (P = 0.009). Similarly, the latter was significantly degraded in a subgroup of patients with BMI >or=30 kg/m2 (P < 0.05). Although the proportion of segments with diagnostic image quality was equal in all BMI subgroups, linear regression suggested 25 kg/m as the cut-off until which excellent or good image quality can be achieved. Sensitivity, specificity, positive, and negative predictive values were 91.6%, 93%, 75.2%, and 97.9% on a per-segment and 100%, 77.5%, 90.4%, and 100% on a per-patient level. In both multivariate analysis and comparison of subgroups, there was no significant effect of BMI on the per-segment diagnostic accuracy.
  
  
  CONCLUSIONS
  Although in an unselected population, obesity turns out to have an independent impact on image quality, there is no translation of this effect into a deterioration of diagnostic accuracy.
authors.affiliation: Department of Diagnostic Radiology, Eberhard-Karls-University, Tübingen, Germany. h.brodoefel@t-online.de
authors.forename: Harald
authors.initials: H
authors.lastname: Brodoefel
authors.forename: Ilias
authors.initials: I
authors.lastname: Tsiflikas
authors.forename: Christof
authors.initials: C
authors.lastname: Burgstahler
authors.forename: Anja
authors.initials: A
authors.lastname: Reimann
authors.forename: Christoph
authors.initials: C
authors.lastname: Thomas
authors.forename: Stephen
authors.initials: S
authors.lastname: Schroeder
authors.forename: Andreas F
authors.initials: AF
authors.lastname: Kopp
authors.forename: Claus D
authors.initials: CD
authors.lastname: Claussen
authors.forename: Martin
authors.initials: M
authors.lastname: Heuschmid
mesh_terms: D015992:Body Mass Index; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000473:pathology; D003331:Coronary Vessels / Q000473:pathology*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000503:physiopathology*; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000295:instrumentation*