Acute renal infarction due to fungal vascular invasion in disseminated candidiasis.
Disseminated candidiasis occurs almost exclusively in leukemic patients recovering from neutropenia. Although renal involvement can be a sequela of disseminated candidiasis, acute renal infarction secondary to Candida invading the renal vasculature has not previously been reported. Our patient, who was being treated for acute myelogenous leukemia, developed complete obstruction of the right renal vessels during the course of 36 hours as documented by serial renal ultrasound scans with Doppler investigation of the vasculature. Histopathologic examination of the nephrectomy specimen revealed complete infarction of the kidney secondary to Candida spp. infiltrating the parenchyma and occluding the hilar vessels.
McGee
Shawn M
SM
Department of Urology, Mayo Medical School and Mayo Clinic, Rochester, Minnesota 55905, USA. mcgee.shawn@mayo.edu
Thompson
Carrie A
CA
Granberg
Candace F
CF
Hutcheson
Joel C
JC
Vandersteen
David R
DR
Reinberg
Yuri
Y
Wolpert
James J
JJ
D000208:Acute Disease; D002177:Candidiasis / Q000150:complications*; D002648:Child; D005260:Female; D006801:Humans; D007238:Infarction / Q000382:microbiology*; D007668:Kidney / Q000098:blood supply*