Therapeutic vaccines for non-Hodgkin B-cell lymphoma.
Despite current therapeutic strategies for B-cell lymphoma, including chemotherapy and transplantation, the majority of patients are not cured. The characterisation of several tumour antigens has made immunotherapy an interesting approach to the treatment of patients with lymphoma. The idiotype region in the immunoglobulin expressed by the tumour B cells is not only a clonal marker but also a tumour-specific antigen. For this reason, the idiotype is an ideal target for immunotherapy. Extensive studies of idiotype vaccination have been done in murine lymphoma models and some of these strategies are now being tested in clinical trials. In the last few years, new strategies to improve the immune response against lymphoma cells have been studied, including the use of DNA or recombinant viruses encoding tumour-antigens, genetically modified tumour cells and a number of immune adjuvants targeting dendritic cells, T cells or NK cells.
Briones
Javier
J
Department of Clinical Hematology, Hospital Santa Creu i Sant Pau, Barcelona, Spain. Jbriones@santpau.cat
D019496:Cancer Vaccines / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D007167:Immunotherapy; D016393:Lymphoma, B-Cell / Q000628:therapy*
D019496:Cancer Vaccines
Proc Natl Acad Sci U S A. 1995 Aug 29;92(18):8200-4
7545296
Nat Med. 1997 May;3(5):558-61
9142127
Curr Opin Oncol. 1998 Nov;10(6):533-41
9818232
Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):703-8
9892697
Cancer Immunol Immunother. 2008 Aug;57(8):1115-24
18193223
Annu Rev Med. 1999;50:507-29
10073291
Blood. 2006 Mar 1;107(5):1955-62
16210338
Nat Immunol. 2002 Jul;3(7):611-8
12087419
Nat Med. 1998 Nov;4(11):1281-6
9809552
Nature. 1993 Apr 22;362(6422):755-8
8469286
Blood. 2007 Nov 1;110(9):3192-201
17616639
Blood. 2002 Apr 1;99(7):2512-7
11895787
Adv Drug Deliv Rev. 2006 Oct 1;58(8):931-47
17030074
Blood. 2002 Mar 1;99(5):1517-26
11861263
Nature. 1998 Mar 19;392(6673):245-52
9521319
Trends Immunol. 2001 Feb;22(2):102-7
11286712
Nat Med. 1996 Sep;2(9):1038-41
8782465
Immunol Today. 1994 Feb;15(2):48-51
8155261
J Immunol. 1996 Jan 1;156(1):224-31
8598466
Cancer Res. 2001 Jun 1;61(11):4497-505
11389081
J Leukoc Biol. 2000 Jan;67(1):2-17
10647992
Blood. 1997 May 1;89(9):3129-35
9129015
Cancer Res. 2006 Apr 15;66(8):4496-502
16618777
Annu Rev Med. 2004;55:355-72
14746526
J Exp Med. 2007 Oct 29;204(11):2641-53
17923500
Annu Rev Immunol. 2007;25:297-336
17150027
N Engl J Med. 2004 Nov 18;351(21):2159-69
15548776
Trends Mol Med. 2001 Dec;7(12):566-72
11733220
Proc Natl Acad Sci U S A. 1978 May;75(5):2411-5
97669
Annu Rev Med. 2004;55:477-503
14746532
Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10067-71
9707601
Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14660-5
9405669
Nat Rev Cancer. 2008 Feb;8(2):108-20
18219306
Nat Rev Immunol. 2007 May;7(5):329-39
17438573
Clin Cancer Res. 2005 Oct 1;11(19 Pt 1):6916-23
16203783
Cancer Res. 2002 Jun 1;62(11):3195-9
12036933
Bull Cancer. 2008 Mar;95(3):320-6
18390412
J Exp Med. 2000 May 15;191(10):1699-708
10811863
J Immunol. 2002 Nov 1;169(9):5227-35
12391241
Blood. 2008 Aug 1;112(3):610-8
18519811
Blood. 1998 Aug 15;92(4):1184-90
9694706
Nat Med. 2005 Sep;11(9):986-91
16116429
Nat Med. 1999 Oct;5(10):1171-7
10502821
J Clin Oncol. 2000 Dec 1;18(23):3964-73
11099326
Cancer Res. 2002 Oct 15;62(20):5845-52
12384547
J Clin Invest. 1998 Mar 1;101(5):1133-41
9486984
J Immunol. 2000 May 1;164(9):4797-803
10779787
Blood. 2001 Mar 1;97(5):1370-7
11222382
Nat Rev Immunol. 2007 Aug;7(8):585-98
17653126
N Engl J Med. 1992 Oct 22;327(17):1209-15
1406793
J Clin Invest. 2000 Apr;105(8):1031-4
10772644
Immunol Rev. 2004 Jun;199:201-16
15233736
J Immunol. 1996 May 15;156(10):3858-65
8621924
J Exp Med. 1997 Oct 20;186(8):1247-56
9334364
Nat Immunol. 2001 Mar;2(3):203-9
11224518
J Natl Cancer Inst. 2003 Apr 2;95(7):548-55
12671023
Nat Biotechnol. 1999 Mar;17(3):253-8
10096292
J Immunol. 1999 Apr 15;162(8):4790-5
10202021
J Immunol. 1997 Apr 1;158(7):3270-6
9120283
Nat Med. 1996 Jan;2(1):52-8
8564842
J Virol. 1996 Jul;70(7):4805-10
8676512
Nature. 2000 Dec 7;408(6813):659-60
11130055
Blood. 2000 Nov 1;96(9):2917-24
11049967