title: Multimodality palliative treatment of (111)In-pentetreotide negative/(123)I-MIBG positive metastatic carcinoid - a case report.
abstract: Patients with carcinoid tumours frequently present with metastatic disease. There are only a few therapeutic options for these patients, and the main goal of palliative treatment is to reduce symptoms and thus to improve quality of life. Current therapy includes surgical resection, hepatic artery embolisation, chemotherapy and somatostatin analogue treatment; however, all these options have limitations. It seems probable that therapeutic modalities based on radiopharmaceuticals may provide better therapy, not only in relation to symptom reduction but may also improve patient survival. In this case report we present a 46-year-old woman with a symptomatic carcinoid, who at the time of diagnosis had liver and abdominal lymph node metastases, the primary tumour being located in the terminal ileum. (111)In-pentetreotide scanning was negative, whereas (123)I-MIBG scanning showed high avidity in the tumour tissue. After right hemicolectomy, two courses of (131)I-MIBG treatment were given (12.95 GBq and 12 GBq, respectively). After the second dose of (131)I-MIBG temporary pancytopenia was present. Octreotide therapy was given empirically only for a short time and was stopped because of drug intolerance. The patient underwent tricuspid and pulmonary valve replacement because of her carcinoid heart disease, followed by two courses of embolisation of liver metastases. While (131)I-MIBG therapy reduced the patient's symptoms of flushing and diarrhoea, there has not yet been any effect on tumour response or 5-HIAA production. This case illustrates the multimodality and multidisciplinary approach to such patients.
authors.affiliation: Department of Endocrinology, William Harvey Research Institute, Barts and the London, Queen Mary School of Medicine, University of London, UK.
authors.forename: Dorota
authors.initials: D
authors.lastname: Dworakowska
authors.forename: Maria
authors.initials: M
authors.lastname: Gueorguiev
authors.forename: Ken
authors.initials: K
authors.lastname: Laji
authors.forename: Ashley B
authors.initials: AB
authors.lastname: Grossman
mesh_terms: D019797:3-Iodobenzylguanidine / Q000032:analysis / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002276:Carcinoid Tumor / Q000737:chemistry / Q000556:secondary* / Q000628:therapy*; D003082:Colectomy; D005260:Female; D006801:Humans; D007078:Ileal Neoplasms / Q000737:chemistry / Q000628:therapy*; D008113:Liver Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D008875:Middle Aged; D015282:Octreotide / Q000031:analogs & derivatives / Q000032:analysis; D010166:Palliative Care; D004369:Pentetic Acid / Q000031:analogs & derivatives / Q000032:analysis
chemical_list: C071632:SDZ 215-811; D019797:3-Iodobenzylguanidine; D004369:Pentetic Acid; D015282:Octreotide