title: [Resting functional MRI with default mode-based functional connectivity analysis for localization of epileptic activity].
abstract: OBJECTIVE
  Using the functional connectivity analysis based on the underlying neurophysiological characteristic that epileptic discharges can induce change of brain default mode, to develop a technique for epileptogenic localization using functional MRI (fMRI) without simultaneous electroencephalography (EEG).
  
  
  METHODS
  A data-driven method that jointly employed independent component analysis and functional connectivity analysis was used for the resting functional MRI data analysis of 12 focal epileptic patients. The independent components were ranged according to the coefficients of the negative correlation between independent component time course and the signal temporal course in the region of posterior cingulate cortex. The results were comparatively studied with simultaneous EEG-fMRI.
  
  
  RESULTS
  In the 10 successful results from 12 patients underwent EEG-fMRI examination, the outcomes of eight subjects were concordant with pathological foci. While the results of all 10 patients processed by data-driven method were concordant with pathological foci, besides the other patients who failed to perform EEG-fMRI examination. Meanwhile, the default mode was well mapped in all patients.
  
  
  CONCLUSIONS
  The default mode-based functional connectivity analysis can localize the epileptogenic foci effectively without simultaneous EEG, besides to detect the default mode of epileptic patients.
authors.affiliation: Department of Medical Imaging, Nanjing General Hospital of Nanjing Military Command, Clinical School of Medical College, Nanjing University, Nanjing 210002, China.
authors.forename: Zhi-qiang
authors.initials: ZQ
authors.lastname: Zhang
authors.forename: Guang-ming
authors.initials: GM
authors.lastname: Lu
authors.forename: Qi-fu
authors.initials: QF
authors.lastname: Tan
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhong
authors.forename: Lei
authors.initials: L
authors.lastname: Tian
authors.forename: Jian-guo
authors.initials: JG
authors.lastname: Zhu
authors.forename: Shi-jie
authors.initials: SJ
authors.lastname: Wang
authors.forename: Kang-jian
authors.initials: KJ
authors.lastname: Sun
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Yi-jun
authors.initials: YJ
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male