[Ofloxacin is contraindicated in case of G6PD deficiency: is it evidenced based?].
G6PD deficiency is very frequent with almost 400 millions of patients worldwide in Asia, Africa and Mediterranean. G6PD deficiency is involved in mild or severe haemolysis and the precipitating factor is usually a drug. More than 100 drugs have been implicated and fluoroquinolones are one of the more classic. However, the literature review shows that only a few observations have been clearly documented.
Carmoi
T
T
Service de médecine interne, HIA Val-de-Grâce, 74, boulevard de Port-Royal, 75005 Paris, France. t.carmoi@wanadoo.fr
Bordier
L
L
Bonnefoy
S
S
Callot
D
D
Lecoules
S
S
Algayres
J-P
JP
D000075202:Contraindications; D048909:Diabetes Complications / Q000188:drug therapy / Q000382:microbiology*; D004927:Escherichia coli Infections / Q000188:drug therapy*; D005260:Female; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications*; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D008875:Middle Aged; D015242:Ofloxacin / Q000627:therapeutic use*; D014552:Urinary Tract Infections / Q000188:drug therapy*
D007328:Insulin; D015242:Ofloxacin