[Measurement of pulmonary inflammation in cystic fibrosis].
Lung inflammation is a pivotal phenomenon in the pathogenesis of cystic fibrosis. Inflammation can be measured and quantified within a research perspective, as well as in daily clinical practice. In this review paper, the "Inflammation Task Force" of the "Société Française de Mucoviscidose" has reviewed the literature regarding the various techniques currently available (bronchoalveolar lavage, sputum analysis, nasal wash and brushing, exhaled breath condensates, carbon monoxide and nitric oxide, and systemic measurements (plasma and urine)). The interpretation of all these determinations in children and adults is also discussed.
Fayon
M
M
CHU de Bordeaux, France. michael.fayon@chu-bordeaux.fr
Chiron
R
R
Abely
M
M
D000328:Adult; D000367:Age Factors; D000975:Antioxidants; D001706:Biopsy; D001944:Breath Tests; D001980:Bronchi / Q000473:pathology; D018893:Bronchoalveolar Lavage / Q000379:methods; D002248:Carbon Monoxide / Q000032:analysis; D002648:Child; D003550:Cystic Fibrosis / Q000150:complications / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007223:Infant; D007249:Inflammation / Q000378:metabolism; D018836:Inflammation Mediators; D015227:Lipid Peroxidation; D045726:Metalloproteases / Q000032:analysis; D017817:Nasal Lavage Fluid; D009569:Nitric Oxide / Q000032:analysis; D018384:Oxidative Stress; D010196:Pancreatic Elastase / Q000032:analysis; D011014:Pneumonia / Q000175:diagnosis* / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D017382:Reactive Oxygen Species; D015203:Reproducibility of Results; D013183:Sputum / Q000378:metabolism; D013997:Time Factors
D000975:Antioxidants; D018836:Inflammation Mediators; D017382:Reactive Oxygen Species; D009569:Nitric Oxide; D002248:Carbon Monoxide; D045726:Metalloproteases; D010196:Pancreatic Elastase