Axonal neuropathy with prolonged sulphasalazine use.
Sulphasalazine, one of the 5-amino-salicylates, is widely used for the treatment of inflammatory bowel diseases and arthritis. Among the reported adverse effects are blood dyscrasias and hepatic failure. Peripheral neuropathy has been reported as a rare adverse drug reaction to sulphasalazine. Most reported patients developed symptoms several weeks after onset of treatment. We describe a patient with an axonal polyneuropathy that occurred after two years of treatment with sulphasalazine.
Liedorp
M
M
Department of Neurology and the Department of Rheumatology, V.U. University Medical Centre, Amsterdam, The Netherlands. m.liedorp@vumc.nl
Voskuyl
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AE
Van Oosten
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D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D020258:Neurotoxicity Syndromes / Q000209:etiology*; D011115:Polyneuropathies / Q000139:chemically induced*; D025242:Spondylarthropathies / Q000188:drug therapy; D012460:Sulfasalazine / Q000008:administration & dosage / Q000009:adverse effects*; D055815:Young Adult
D000894:Anti-Inflammatory Agents, Non-Steroidal; D012460:Sulfasalazine