title: Relations between concentrations of asymmetric dimethylarginine and neopterin as potential risk factors for cardiovascular diseases in haemodialysis-treated patients.
abstract: OBJECTIVE
  To investigate the correlation between concentrations of asymmetric dimethylarginine (ADMA) and neopterin (NP) as potential risk factors for cardiovascular diseases in chronic renal failure patients.
  
  
  METHODS
  In this study, 33 patients with renal failure before and after haemodialysis were compared with healthy control subjects. Serum ADMA and NP levels were measured using high performance liquid chromatography (HPLC).
  
  
  RESULTS
  When ADMA and NP concentrations in renal failure patients were compared before and after dialysis, before dialysis ADMA and NP concentrations were higher than those in the control group. However, ADMA and NP levels showed a falling mean and clear after dialysis. While there is no correlation between ADMA and NP levels before dialysis, there is a mean and positive correlation between ADMA and NP levels after dialysis.
  
  
  CONCLUSIONS
  Potential risk factors for cardiovascular diseases include high concentrations of both ADMA and NP levels in chronic renal failure patients. A correlation mean between ADMA and NP levels after dialysis was found, but no correlation between ADMA and NP levels before haemodialysis was discovered. These can be evaluated as two different risk factors independent from each other.
authors.affiliation: Faculty of Science and Arts, Department of Biology, Gazi University, Teknikokullar, Ankara, Turkey.
authors.forename: Emre
authors.initials: E
authors.lastname: Avci
authors.forename: Sule
authors.initials: S
authors.lastname: Coskun
authors.forename: Erdinc
authors.initials: E
authors.lastname: Cakir
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Kurt
authors.forename: Emin
authors.initials: E
authors.lastname: Ozgur Akgul
authors.forename: Cumhur
authors.initials: C
authors.lastname: Bilgi
mesh_terms: D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D019798:Neopterin / Q000097:blood*; D006435:Renal Dialysis; D012307:Risk Factors
chemical_list: C487735:dimethylarginine; D019798:Neopterin; D001120:Arginine