Haemolytic disease of fetus and newborn caused by ABO antibodies in a cisAB offspring.
ABO hemolytic disease of fetus and newborn (ABO-HDFN) occurs almost exclusively in infants of blood group A or B who are born to group O mothers because IgG anti-A or -B occurs more commonly in group O than in group A or B individuals. We report a case of clinically significant ABO-HDFN where the mother was blood group O with elevated IgG anti-A and anti-B titers and delivered a child with an A2B phenotype. This unusual ABO constellation between mother and infant was based on the inheritance of a rare ABO allele encoding for a glycosyltransferase capable of synthesizing both A and B antigens. Because both anti-A and anti-B antibodies may have been involved in hemolysis in this case, it may be relevant to consider the cisAB phenomenon when monitoring ABO-incompatible pregnancies and births.
Deng
Zhi-Hui
ZH
ShenZhen Institute of Transfusion Medicine, ShenZhen Blood Center, ShenZhen, GuangDong, PR China. zhihui_deng@yahoo.com.com.cn
Seltsam
Axel
A
Ye
You-Wan
YW
Yu
Qiong
Q
Li
Qian
Q
Su
Yu-Qing
YQ
Liang
Yan-Lian
YL
Zang
Hao
H
D000017:ABO Blood-Group System / Q000276:immunology*; D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D001788:Blood Grouping and Crossmatching; D004899:Erythroblastosis, Fetal / Q000097:blood / Q000209:etiology* / Q000276:immunology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007231:Infant, Newborn; D007518:Isoantibodies / Q000097:blood / Q000276:immunology; D007519:Isoantigens / Q000276:immunology*; D007567:Jaundice, Neonatal / Q000209:etiology*; D008297:Male; D008431:Maternal-Fetal Exchange; D009844:Oligosaccharides / Q000276:immunology*; D025942:Oligosaccharides, Branched-Chain; D010298:Parity; D010375:Pedigree; D010641:Phenotype; D011247:Pregnancy; D014312:Trisaccharides / Q000276:immunology*
D000017:ABO Blood-Group System; D007074:Immunoglobulin G; D007518:Isoantibodies; D007519:Isoantigens; D009844:Oligosaccharides; D025942:Oligosaccharides, Branched-Chain; D014312:Trisaccharides; C101335:blood group A trisaccharide; C406478:blood group B trisaccharide