title: Focusing on symptoms rather than diagnoses in brain dysfunction: conscious and nonconscious expression in impulsiveness and decision-making.
abstract: Symptoms and syndromes in neuropathology, whether expressed in conscious or nonconscious behaviour, remain imbedded in often complex diagnostic categories. Symptom-based strategies for studying brain disease states are driven by assessments of presenting symptoms, signs, assay results, neuroimages and biomarkers. In the present account, symptom-based strategies are contrasted with existing diagnostic classifications. Topics include brain areas and regional circuitry underlying decision-making and impulsiveness, and motor and learned expressions of explicit and implicit processes. In three self-report studies on young adult and adolescent healthy individuals, it was observed that linear regression analyses between positive and negative affect, self-esteem, four different types of situational motivation: intrinsic, identified regulation, extrinsic regulation and amotivation, and impulsiveness predicted significant associations between impulsiveness with negative affect and lack of motivation (i.e., amotivation) and internal locus of control, on the one hand, and non-impulsiveness with positive affect, self-esteem, and high motivation (i.e., intrinsic motivation and identified regulation), on the other. Although presymptomatic, these cognitive-affective characterizations illustrate individuals' choice behaviour in appraisals of situations, events and proclivities essentially of distal perspective. Neuropathological expressions provide the proximal realities of symptoms and syndromes with underlying dysfunctionality of brain regions, circuits and molecular mechanisms.
authors.affiliation: Servicio Psiquiatrico, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.
authors.forename: T
authors.initials: T
authors.lastname: Palomo
authors.forename: R J
authors.initials: RJ
authors.lastname: Beninger
authors.forename: R M
authors.initials: RM
authors.lastname: Kostrzewa
authors.forename: T
authors.initials: T
authors.lastname: Archer
mesh_terms: D000293:Adolescent; D000328:Adult; D001526:Behavioral Symptoms / Q000209:etiology*; D001927:Brain Diseases / Q000150:complications* / Q000175:diagnosis*; D002648:Child; D003243:Consciousness; D003657:Decision Making; D005260:Female; D006801:Humans; D007175:Impulsive Behavior; D016014:Linear Models; D008297:Male; D055815:Young Adult
references.citation: Addiction. 1998 May;93(5):729-38
references.pmid: 9692271
references.citation: Psychopharmacology (Berl). 2001 Jul;156(2-3):234-58
references.pmid: 11549226
references.citation: Neuropsychologia. 2002;40(5):471-8
references.pmid: 11749977
references.citation: Trends Neurosci. 1989 Oct;12(10):366-75
references.pmid: 2479133
references.citation: Am J Med Genet B Neuropsychiatr Genet. 2004 Apr 1;126B(1):37-42
references.pmid: 15048645
references.citation: Psychopharmacology (Berl). 2000 Nov;152(4):362-75
references.pmid: 11140328
references.citation: Alcohol Clin Exp Res. 2006 Nov;30(11):1866-70
references.pmid: 17067350
references.citation: Schizophr Bull. 2007 May;33(3):635-41
references.pmid: 17412710
references.citation: Nat Neurosci. 2000 Mar;3(3):211-6
references.pmid: 10700251
references.citation: Neurotox Res. 2007 Jan;11(1):41-50
references.pmid: 17449447
references.citation: Alcohol Clin Exp Res. 2000 May;24(5):611-21
references.pmid: 10832902
references.citation: Nurs Econ. 1997 Jul-Aug;15(4):183-90
references.pmid: 9282030
references.citation: Int J Epidemiol. 2002 Dec;31(6):1235-9
references.pmid: 12540728
references.citation: J Neurochem. 2004 Sep;90(6):1464-76
references.pmid: 15341530
references.citation: Science. 2004 Oct 15;306(5695):503-7
references.pmid: 15486304
references.citation: Learn Mem. 2006 Sep-Oct;13(5):650-8
references.pmid: 17015860
references.citation: Science. 1997 Feb 28;275(5304):1293-5
references.pmid: 9036851
references.citation: Science. 2004 Jun 25;304(5679):1979-83
references.pmid: 15218151
references.citation: Nat Neurosci. 2002 Nov;5(11):1103-4; author reply 1104
references.pmid: 12403997
references.citation: Pers Soc Psychol Rev. 2005;9(4):312-33
references.pmid: 16223354
references.citation: Occup Health Nurs. 1971 Nov;19(11):23-5 passim
references.pmid: 4398942
references.citation: Psychol Bull. 1975 Jul;82(4):463-96
references.pmid: 1099599
references.citation: Trends Cogn Sci. 2002 Oct 1;6(10):426-431
references.pmid: 12413576
references.citation: J Neurobiol. 2005 Jul;64(1):116-31
references.pmid: 15883999
references.citation: Schizophr Res. 2005 Jun 1;75(1):65-75
references.pmid: 15820325
references.citation: Addiction. 1999 May;94(5):697-707
references.pmid: 10563034
references.citation: Am J Psychiatry. 1997 Oct;154(10):1430-5
references.pmid: 9326827
references.citation: Int Rev Neurobiol. 2006;72:119-30
references.pmid: 16697294
references.citation: J Psychiatry Neurosci. 2008 Jan;33(1):47-53
references.pmid: 18197272
references.citation: Addict Behav. 1997 Jul-Aug;22(4):437-46
references.pmid: 9290854
references.citation: Br J Psychiatry. 1988 Feb;152:180-7
references.pmid: 3167333
references.citation: Neuropsychopharmacology. 2006 Jul;31(7):1393-405
references.pmid: 16205781
references.citation: Psychol Monogr. 1966;80(1):1-28
references.pmid: 5340840
references.citation: Brain Res. 1983 Oct;287(2):173-96
references.pmid: 6357357
references.citation: Psychiatry Res. 2001 Oct 10;104(1):27-37
references.pmid: 11600187
references.citation: Neurotox Res. 2008 Aug;14(1):57-70
references.pmid: 18790725
references.citation: J Pers Soc Psychol. 1994 Sep;67(3):357-65
references.pmid: 7965599
references.citation: Eur J Biochem. 1993 Apr 15;213(2):689-99
references.pmid: 8386634
references.citation: Psychiatry Res. 2006 Jan 30;146(1):1-11
references.pmid: 16388934
references.citation: Child Neuropsychol. 1999 Dec;5(4):230-41
references.pmid: 10925707
references.citation: Brain Cogn. 1999 Dec;41(3):351-64
references.pmid: 10585241
references.citation: Biol Psychiatry. 2001 Sep 15;50(6):418-24
references.pmid: 11566158
references.citation: Psychopharmacology (Berl). 2002 Dec;164(4):385-91
references.pmid: 12457268
references.citation: Brain Cogn. 2006 Mar;60(2):109-17
references.pmid: 16481083
references.citation: Psychol Med. 2002 Jan;32(1):105-17
references.pmid: 11885567
references.citation: J Pers Soc Psychol. 1988 Jun;54(6):1063-70
references.pmid: 3397865
references.citation: Mol Psychiatry. 2002;7(10):1039-53
references.pmid: 12476318
references.citation: Nat Neurosci. 2004 Aug;7(8):887-93
references.pmid: 15235607
references.citation: Psychopharmacology (Berl). 2004 Nov;176(2):182-94
references.pmid: 15083253
references.citation: Eur Psychiatry. 2006 Jun;21(4):270-3
references.pmid: 16762532
references.citation: Cell. 2006 May 19;125(4):785-99
references.pmid: 16713568
references.citation: Br J Clin Psychol. 1989 Feb;28(1):53-9
references.pmid: 2522329
references.citation: Psychiatry Res. 2005 Jun 30;135(3):191-201
references.pmid: 15996748
references.citation: Neurotox Res. 2007 Jul;12(1):43-60
references.pmid: 17513199
references.citation: Neuropsychologia. 2001;39(4):376-89
references.pmid: 11164876
references.citation: J Child Psychol Psychiatry. 2006 Mar-Apr;47(3-4):226-61
references.pmid: 16492258
references.citation: Brain. 2002 Mar;125(Pt 3):624-39
references.pmid: 11872618
references.citation: Pediatr Neurol. 2001 Sep;25(3):190-8
references.pmid: 11587872
references.citation: Cereb Cortex. 2006 Jan;16(1):106-14
references.pmid: 15829733
references.citation: J Int Neuropsychol Soc. 2006 Mar;12(2):210-23
references.pmid: 16573855
references.citation: Nat Rev Neurosci. 2003 Oct;4(10):829-39
references.pmid: 14523382
references.citation: Psychiatry Res. 2007 Jan 15;149(1-3):129-38
references.pmid: 17046069
references.citation: Neurotox Res. 2008 Aug;14(1):45-56
references.pmid: 18790724
references.citation: Biol Psychiatry. 2004 May 15;55(10):965-70
references.pmid: 15121478
references.citation: Ment Retard Dev Disabil Res Rev. 2000;6(2):142-7
references.pmid: 10899808
references.citation: Psychopharmacology (Berl). 2001 Jan;153(3):295-306
references.pmid: 11271401
references.citation: Neurotox Res. 2008 Aug;14(1):21-44
references.pmid: 18790723
references.citation: Hippocampus. 2001;11(6):776-82
references.pmid: 11811672
references.citation: J Neurosci. 2002 Jul 1;22(13):5619-29
references.pmid: 12097513
references.citation: Neuropsychologia. 2005;43(7):1099-106
references.pmid: 15769495
references.citation: Psychiatry Res. 1980 Oct;3(2):225-36
references.pmid: 6171841
references.citation: Psychophysiology. 1978 Mar;15(2):165-72
references.pmid: 652911
references.citation: Cereb Cortex. 2005 Jan;15(1):58-63
references.pmid: 15217900
references.citation: Biol Psychiatry. 2005 May 15;57(10):1209-11
references.pmid: 15866563
references.citation: Psychosom Med. 1964 Mar-Apr;26:125-34
references.pmid: 14132974
references.citation: Arch Neurol. 2004 May;61(5):641-4
references.pmid: 15148138
references.citation: J Psychopharmacol. 2003 Jun;17(2):216-22
references.pmid: 12870570
references.citation: Acta Psychiatr Scand. 2003 May;107(5):378-84
references.pmid: 12752034
references.citation: Neuropsychologia. 2000;38(8):1180-7
references.pmid: 10838152
references.citation: Science. 2005 Dec 9;310(5754):1624-5
references.pmid: 16339434
references.citation: Arch Gen Psychiatry. 1999 Apr;56(4):356-63
references.pmid: 10197833
references.citation: Arch Clin Neuropsychol. 2006 Feb;21(2):175-84
references.pmid: 16307864
references.citation: Annu Rev Neurosci. 2007;30:259-88
references.pmid: 17600522
references.citation: Br J Psychiatry. 2001 Apr;178:352-9
references.pmid: 11282815
references.citation: Arch Gen Psychiatry. 2005 Jul;62(7):799-805
references.pmid: 15997022
references.citation: Nature. 1995 Aug 17;376(6541):572-5
references.pmid: 7637804
references.citation: Alcohol Clin Exp Res. 2004 Nov;28(11):1657-65
references.pmid: 15547452
references.citation: Dialogues Clin Neurosci. 2006;8(1):9-16
references.pmid: 16640109
references.citation: Neuropsychologia. 2002;40(12):2013-22
references.pmid: 12207998
references.citation: Am J Ment Retard. 2007 Mar;112(2):79-93
references.pmid: 17295556
references.citation: Neurosci Biobehav Rev. 2007;31(4):597-618
references.pmid: 17316796
references.citation: Trends Cogn Sci. 2005 Aug;9(8):355-7
references.pmid: 16006177
references.citation: Br J Haematol. 1975 Oct;31(2):209-15
references.pmid: 1201239
references.citation: J Affect Disord. 2003 Jan;73(1-2):105-11
references.pmid: 12507743
references.citation: Science. 2003 Jun 13;300(5626):1755-8
references.pmid: 12805551
references.citation: Arch Gen Psychiatry. 2003 Jun;60(6):601-9
references.pmid: 12796223
references.citation: Neurotox Res. 2002 Aug-Sep;4(5-6):489-502
references.pmid: 12754162
references.citation: Hum Mol Genet. 2001 Jul 15;10(15):1611-7
references.pmid: 11468279
references.citation: Trends Neurosci. 2007 May;30(5):188-93
references.pmid: 17368565
references.citation: Mol Psychiatry. 2005 Aug;10(8):758-64
references.pmid: 15940305
references.citation: Pharmacopsychiatry. 2006 Feb;39 Suppl 1:S10-4
references.pmid: 16508890
references.citation: Brain. 2000 Nov;123 ( Pt 11):2189-202
references.pmid: 11050020
references.citation: Neuropsychology. 2003 Jul;17(3):420-8
references.pmid: 12959508
references.citation: Science. 2007 Nov 23;318(5854):1257
references.pmid: 18033875
references.citation: Int J Psychophysiol. 2006 Nov;62(2):203-11
references.pmid: 16828187
references.citation: Nat Neurosci. 1999 Nov;2(11):1032-7
references.pmid: 10526345
references.citation: Psychiatry Res. 2004 Jun 30;127(1-2):101-9
references.pmid: 15261709
references.citation: Ciba Found Symp. 1976 Dec 7-9;(51):201-25
references.pmid: 1052031
references.citation: J Abnorm Psychol. 1988 Aug;97(3):346-53
references.pmid: 3192830
references.citation: Mol Psychiatry. 2007 Jan;12(1):87-93
references.pmid: 16969366
references.citation: Pharmacol Biochem Behav. 1986 Jul;25(1):141-4
references.pmid: 3018790
references.citation: Cognition. 1994 Apr-Jun;50(1-3):7-15
references.pmid: 8039375
references.citation: Psychiatry Clin Neurosci. 2001 Apr;55(2):111-4
references.pmid: 11285088
references.citation: Am J Psychiatry. 2005 May;162(5):915-23
references.pmid: 15863793
references.citation: Alcohol Clin Exp Res. 2003 May;27(5):773-9
references.pmid: 12766621
references.citation: Nat Neurosci. 2005 Nov;8(11):1458-63
references.pmid: 16251988
references.citation: J Exp Psychol Learn Mem Cogn. 2003 Mar;29(2):224-34
references.pmid: 12696811
references.citation: Alcohol Alcohol. 2003 Jan-Feb;38(1):40-4
references.pmid: 12554606
references.citation: Nat Rev Neurosci. 2004 Nov;5(11):863-73
references.pmid: 15496864
references.citation: J Neurochem. 1986 Sep;47(3):794-9
references.pmid: 2942640
references.citation: Prog Neuropsychopharmacol Biol Psychiatry. 2005 Jun;29(5):713-7
references.pmid: 15908092
references.citation: Psychol Med. 2003 Nov;33(8):1335-40
references.pmid: 14672242
references.citation: Cell. 2006 Oct 6;127(1):49-58
references.pmid: 17018276
references.citation: Neuropsychology. 2005 Nov;19(6):799-805
references.pmid: 16351355
references.citation: J Pers Assess. 1996 Jun;66(3):488-524
references.pmid: 8667144
references.citation: J Biol Chem. 2006 Jul 7;281(27):18802-15
references.pmid: 16651266
references.citation: Cell. 2004 Feb 6;116(3):467-79
references.pmid: 15016380
references.citation: Prog Hematol. 1986;14:23-53
references.pmid: 3511517
references.citation: Alcohol Alcohol. 2003 Mar-Apr;38(2):151-6
references.pmid: 12634263
references.citation: Behav Neurosci. 2004 Dec;118(6):1324-30
references.pmid: 15598141
references.citation: Biol Psychiatry. 1997 May 15;41(10):1045-61
references.pmid: 9129785
references.citation: Addict Behav. 1999 May-Jun;24(3):449-53
references.pmid: 10400285
references.citation: Nature. 2004 Jul 22;430(6998):419-21
references.pmid: 15269759
references.citation: Schizophr Res. 2004 Aug 1;69(2-3):189-201
references.pmid: 15469193
references.citation: Neurotox Res. 2008 Aug;14(1):71-8
references.pmid: 18790726
references.citation: Cogn Affect Behav Neurosci. 2006 Jun;6(2):91-101
references.pmid: 17007230
references.citation: Eur J Neurosci. 1999 Aug;11(8):2906-16
references.pmid: 10457187
references.citation: Alcohol Clin Exp Res. 2004 Sep;28(9):1338-46
references.pmid: 15365304
references.citation: Bipolar Disord. 2004 Jun;6(3):204-12
references.pmid: 15117399
references.citation: Cogn Affect Behav Neurosci. 2002 Dec;2(4):341-53
references.pmid: 12641178
references.citation: Psychol Med. 2000 Sep;30(5):1025-36
references.pmid: 12027040
references.citation: Trends Neurosci. 1992 Sep;15(9):340-5
references.pmid: 1382333
references.citation: Alcohol Clin Exp Res. 2001 Feb;25(2):185-91
references.pmid: 11236831
references.citation: Lancet. 2005 Jul 16-22;366(9481):237-48
references.pmid: 16023516
references.citation: Alcohol Clin Exp Res. 2004 Apr;28(4):667-75
references.pmid: 15100620
references.citation: Neuropsychologia. 2004;42(11):1447-58
references.pmid: 15246283
references.citation: Ann N Y Acad Sci. 2007 Dec;1121:1-9
references.pmid: 17846153
references.citation: Conscious Cogn. 1999 Dec;8(4):497-509
references.pmid: 10600247
references.citation: Brain Cogn. 2005 Feb;57(1):21-5
references.pmid: 15629209
references.citation: Psychol Bull. 1984 Nov;96(3):465-90
references.pmid: 6393179
references.citation: Nebr Symp Motiv. 1990;38:237-88
references.pmid: 2130258
references.citation: J Clin Psychol. 2001 Jun;57(6):815-28
references.pmid: 11344467
references.citation: Neuron. 2006 Mar 2;49(5):765-75
references.pmid: 16504951
references.citation: Neuron. 2007 Aug 16;55(4):648-61
references.pmid: 17698016
references.citation: Psychol Sci. 2007 Nov;18(11):958-64
references.pmid: 17958709
references.citation: Psychopharmacology (Berl). 1999 Oct;146(4):348-61
references.pmid: 10550486
references.citation: Alcohol Alcohol. 2000 Jan;35(1):52-4
references.pmid: 10684777
references.citation: Arch Gen Psychiatry. 1990 Feb;47(2):181-8
references.pmid: 2405807
references.citation: Addiction. 2001 Jun;96(6):815-22
references.pmid: 11399213
references.citation: Neurotox Res. 2008 Oct;14(2-3):141-50
references.pmid: 19073422
references.citation: Trends Cogn Sci. 2006 Mar;10(3):108-16
references.pmid: 16469524
references.citation: J Clin Psychol. 1995 Nov;51(6):768-74
references.pmid: 8778124
references.citation: Behav Neurosci. 2000 Apr;114(2):374-88
references.pmid: 10832798
references.citation: J Neurosci. 1999 Jul 1;19(13):5473-81
references.pmid: 10377356
references.citation: Science. 2005 Dec 9;310(5754):1680-3
references.pmid: 16339445
references.citation: Annu Rev Pharmacol Toxicol. 1996;36:359-78
references.pmid: 8725394
references.citation: Trends Neurosci. 2007 May;30(5):194-202
references.pmid: 17408759
references.citation: Neuropsychopharmacology. 2002 Sep;27(3):421-9
references.pmid: 12225699
references.citation: Psychopharmacology (Berl). 2006 May;186(1):32-40
references.pmid: 16557416
references.citation: Behav Neurosci. 2001 Oct;115(5):993-1001
references.pmid: 11584932
references.citation: Nat Neurosci. 1999 Sep;2(9):844-7
references.pmid: 10461225
references.citation: Am Psychol. 1994 Aug;49(8):709-24
references.pmid: 8092614
references.citation: J Neurochem. 1958 Oct;3(1):41-51
references.pmid: 13611557
references.citation: Int J Dev Neurosci. 1986;4(1):81-8
references.pmid: 2844061
references.citation: Psychol Rev. 1999 Jan;106(1):3-19
references.pmid: 10197361
references.citation: Psychol Bull. 2001 May;127(3):291-324
references.pmid: 11393298
references.citation: Neuropsychopharmacology. 2006 Sep;31(9):2011-21
references.pmid: 16482083
references.citation: Psychiatry Res. 1997 Mar 24;69(2-3):89-95
references.pmid: 9109176
references.citation: Nat Rev Neurosci. 2006 Jan;7(1):54-64
references.pmid: 16371950
references.citation: J Neurosci. 2007 Jan 24;27(4):951-6
references.pmid: 17251437
references.citation: Am J Clin Nutr. 1989 Sep;50(3 Suppl):607-15; discussion 615-7
references.pmid: 2773840
references.citation: Behav Pharmacol. 2005 May;16(3):181-6
references.pmid: 15864073
references.citation: Psychopharmacology (Berl). 2000 Apr;149(2):147-52
references.pmid: 10805609
references.citation: Psychol Med. 2002 Apr;32(3):417-27
references.pmid: 11989987
references.citation: Biol Psychiatry. 2001 Nov 15;50(10):783-91
references.pmid: 11720697
references.citation: Psychopharmacology (Berl). 2007 Nov;194(4):545-54
references.pmid: 17628790
references.citation: Psychopharmacology (Berl). 2007 Sep;193(4):475-86
references.pmid: 17492273
references.citation: J Neural Transm (Vienna). 2001;108(6):617-27
references.pmid: 11478414
references.citation: Psychol Rev. 2006 Apr;113(2):300-326
references.pmid: 16637763
references.citation: Eur J Pharmacol. 1984 Sep 17;104(3-4):245-51
references.pmid: 6094214
references.citation: Alcohol Clin Exp Res. 2007 Jul;31(7):1169-78
references.pmid: 17511749
references.citation: Cleft Palate J. 1978 Jan;15(1):56-62
references.pmid: 272242
references.citation: Psychiatry Res. 2007 Apr 15;150(3):245-53
references.pmid: 17316823
references.citation: Psychopharmacology (Berl). 2000 May;150(1):90-101
references.pmid: 10867981
references.citation: Neurosci Lett. 2002 Aug 16;328(3):233-6
references.pmid: 12147314
references.citation: Brain Cogn. 1993 Jul;22(2):244-65
references.pmid: 8373576
references.citation: Trends Cogn Sci. 2007 Jun;11(6):258-65
references.pmid: 17475537
references.citation: Trends Cogn Sci. 2005 Apr;9(4):159-62; discussion 162-4
references.pmid: 15808493
references.citation: Neuropsychopharmacology. 2008 Feb;33(3):497-512
references.pmid: 17460616
references.citation: Acta Neuropsychiatr. 2007 Aug;19(4):244-50
references.pmid: 26952891
references.citation: Mol Psychiatry. 1999 Jul;4(4):385-8
references.pmid: 10483057
references.citation: Neurotox Res. 2004;6(3):159-73
references.pmid: 15325956
references.citation: J Neurosci. 1997 Apr 1;17(7):2626-36
references.pmid: 9065522
references.citation: Neuroscience. 2003;116(3):743-52
references.pmid: 12573716
references.citation: Cell Mol Biol (Noisy-le-grand). 2000 Jun;46(4):743-60
references.pmid: 10875437
references.citation: Int J Neuropsychopharmacol. 2007 Jun;10(3):383-99
references.pmid: 16925890
references.citation: Psychopharmacology (Berl). 1999 Oct;146(4):400-12
references.pmid: 10550490
references.citation: Brain Cogn. 2004 Jun;55(1):41-53
references.pmid: 15134842
references.citation: Conscious Cogn. 2006 Jun;15(2):372-85
references.pmid: 16289992
references.citation: Psychopharmacology (Berl). 2001 Jul;156(2-3):284-90
references.pmid: 11549230
references.citation: Psychiatry Res. 2006 Sep 30;144(1):1-15
references.pmid: 16914207
references.citation: Psychiatry Res. 2000 Apr 24;94(1):9-18
references.pmid: 10788673
references.citation: Nat Neurosci. 2005 Sep;8(9):1255-62
references.pmid: 16116457
references.citation: Mol Psychiatry. 2003 Apr;8(4):445-52
references.pmid: 12740602
references.citation: J Abnorm Psychol. 1971 Jun;77(3):223-35
references.pmid: 5556930
references.citation: J Abnorm Psychol. 1957 Jul;55(1):6-10
references.pmid: 13462652
references.citation: Psychopharmacology (Berl). 2005 Jun;180(1):57-62
references.pmid: 15650841
references.citation: Psychopharmacology (Berl). 2005 Nov;182(4):570-8
references.pmid: 16163530
references.citation: Psychol Med. 2001 May;31(4):679-93
references.pmid: 11352370
references.citation: Cereb Cortex. 1996 Mar-Apr;6(2):215-25
references.pmid: 8670652
references.citation: Science. 2006 Aug 4;313(5787):684-7
references.pmid: 16888142
references.citation: Neuropsychologia. 2006;44(8):1315-24
references.pmid: 16513144
references.citation: Cell Mol Biol (Noisy-le-grand). 2000 May;46(3):491-500
references.pmid: 10872737
references.citation: Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):11032-7
references.pmid: 11005874
references.citation: Neuropsychologia. 2002;40(10):1675-89
references.pmid: 11992656