title: Synthesis and immunostimulatory properties of the phosphorothioate analogues of cdiGMP.
abstract: The synthesis of mono- and bisphosphorothioate analogues of 3',5'-cyclic diguanylic acid (cdiGMP) via the modified H-phosphonate chemistry is reported. The immunostimulatory properties of these analogues were compared with those of cdiGMP.
authors.affiliation: Department of Chemistry, Brock University, 500 Glenridge Avenue, St. Catharines, Ont., Canada L2S 3A1. tyan@brocku.ca
authors.forename: Hongbin
authors.initials: H
authors.lastname: Yan
authors.forename: Xiaolu
authors.initials: X
authors.lastname: Wang
authors.forename: Rhonda
authors.initials: R
authors.lastname: KuoLee
authors.forename: Wangxue
authors.initials: W
authors.lastname: Chen
mesh_terms: D001980:Bronchi / Q000378:metabolism; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D006152:Cyclic GMP / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D006801:Humans; D007107:Immune System; D007249:Inflammation; D008956:Models, Chemical; D009504:Neutrophils / Q000378:metabolism; D063065:Organophosphonates / Q000737:chemistry; D010710:Phosphates / Q000737:chemistry*; D014612:Vaccines / Q000737:chemistry
chemical_list: D063065:Organophosphonates; D010710:Phosphates; D014612:Vaccines; C062025:bis(3',5')-cyclic diguanylic acid; D006152:Cyclic GMP; C035638:thiophosphoric acid