title: The formation of nicotinamide by administration of di(2-ethylhexyl)phthalate does not cause growth retardation in young rats in contrast with excess exogenous administration of nicotinamide.
abstract: We investigated the relationship between protein and tryptophan intake and the adverse-effect-level of di(2-ethylhexyl)phthalate (DEHP). Growth retardation of young rats due to DEHP was strengthened by increasing protein level. The addition of tryptophan to the diet caused extreme increases in the nicotinamide formation, but no growth retardation was observed.
authors.affiliation: Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, Shiga, USA. fukkie@shc.usp.ac.jp
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Fukuwatari
authors.forename: Katsumi
authors.initials: K
authors.lastname: Shibata
mesh_terms: D000818:Animals; D004051:Diethylhexyl Phthalate / Q000378:metabolism / Q000494:pharmacology*; D006128:Growth / Q000187:drug effects*; D008297:Male; D009536:Niacinamide / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D009536:Niacinamide; D004051:Diethylhexyl Phthalate