title: A specialized vascular niche for adult neural stem cells.
abstract: Stem cells reside in specialized niches that regulate their self-renewal and differentiation. The vasculature is emerging as an important component of stem cell niches. Here, we show that the adult subventricular zone (SVZ) neural stem cell niche contains an extensive planar vascular plexus that has specialized properties. Dividing stem cells and their transit-amplifying progeny are tightly apposed to SVZ blood vessels both during homeostasis and regeneration. They frequently contact the vasculature at sites that lack astrocyte endfeet and pericyte coverage, a modification of the blood-brain barrier unique to the SVZ. Moreover, regeneration often occurs at these sites. Finally, we find that circulating small molecules in the blood enter the SVZ. Thus, the vasculature is a key component of the adult SVZ neural stem cell niche, with SVZ stem cells and transit-amplifying cells uniquely poised to receive spatial cues and regulatory signals from diverse elements of the vascular system.
authors.affiliation: Department of Neuroscience, College of Physicians and Surgeons, Columbia University, New York City, NY 10032 USA.
authors.forename: Masoud
authors.initials: M
authors.lastname: Tavazoie
authors.forename: Lieven
authors.initials: L
authors.lastname: Van der Veken
authors.forename: Violeta
authors.initials: V
authors.lastname: Silva-Vargas
authors.forename: Marjorie
authors.initials: M
authors.lastname: Louissaint
authors.forename: Lucrezia
authors.initials: L
authors.lastname: Colonna
authors.forename: Bushra
authors.initials: B
authors.lastname: Zaidi
authors.forename: Jose Manuel
authors.initials: JM
authors.lastname: Garcia-Verdugo
authors.forename: Fiona
authors.initials: F
authors.lastname: Doetsch
mesh_terms: D053687:Adult Stem Cells / Q000166:cytology* / Q000502:physiology; D000818:Animals; D001808:Blood Vessels / Q000166:cytology*; D001921:Brain / Q000098:blood supply / Q000166:cytology* / Q000502:physiology; D002454:Cell Differentiation; D002455:Cell Division; D006801:Humans; D020547:Lateral Ventricles / Q000098:blood supply / Q000166:cytology* / Q000502:physiology; D051379:Mice; D008815:Mice, Inbred Strains
references.citation: Science. 2007 Sep 21;317(5845):1722-6
references.pmid: 17823316
references.citation: Mol Cell Neurosci. 1999 Jun;13(6):450-64
references.pmid: 10383830
references.citation: J Neurocytol. 2002 Jul-Aug;31(6-7):437-55
references.pmid: 14501215
references.citation: EMBO J. 2004 Nov 10;23(22):4495-505
references.pmid: 15496983
references.citation: Neurobiol Aging. 1983 Spring;4(1):69-75
references.pmid: 6877490
references.citation: Nat Rev Neurosci. 2006 Jan;7(1):41-53
references.pmid: 16371949
references.citation: Aging Cell. 2006 Apr;5(2):139-52
references.pmid: 16626393
references.citation: Neuron. 2002 Dec 19;36(6):1021-34
references.pmid: 12495619
references.citation: Nat Rev Cancer. 2007 Oct;7(10):733-6
references.pmid: 17882276
references.citation: J Cell Biol. 2004 May 24;165(4):575-89
references.pmid: 15159421
references.citation: Cell. 1999 Jun 11;97(6):703-16
references.pmid: 10380923
references.citation: Science. 1988 Jul 1;241(4861):58-62
references.pmid: 2898810
references.citation: Neuron. 2002 Jun 13;34(6):945-60
references.pmid: 12086642
references.citation: Cell. 1989 Apr 21;57(2):201-9
references.pmid: 2702690
references.citation: Mech Ageing Dev. 2007 Apr;128(4):303-10
references.pmid: 17316762
references.citation: Stem Cells. 2007 Sep;25(9):2146-57
references.pmid: 17569787
references.citation: Nature. 2005 Oct 6;437(7060):894-7
references.pmid: 16208373
references.citation: J Comp Neurol. 2000 Oct 2;425(4):479-94
references.pmid: 10975875
references.citation: Dev Biol. 1997 Jul 1;187(1):36-42
references.pmid: 9224672
references.citation: Neuropathol Appl Neurobiol. 1981 Nov-Dec;7(6):451-62
references.pmid: 7329517
references.citation: J Neurosci. 2003 Apr 1;23(7):2824-32
references.pmid: 12684469
references.citation: Trends Neurosci. 2008 Aug;31(8):392-400
references.pmid: 18603310
references.citation: J Neurosci. 1997 Jul 1;17(13):5046-61
references.pmid: 9185542
references.citation: Cell. 2005 Jul 1;121(7):1109-21
references.pmid: 15989959
references.citation: Neuron. 2008 Jan 24;57(2):178-201
references.pmid: 18215617
references.citation: Nat Neurosci. 2006 Mar;9(3):331-9
references.pmid: 16491078
references.citation: Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14895-900
references.pmid: 8962152
references.citation: Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11946-50
references.pmid: 12181492
references.citation: J Comp Neurol. 2002 Sep 16;451(2):170-88
references.pmid: 12209835
references.citation: Dev Cell. 2006 Mar;10(3):397-405
references.pmid: 16516842
references.citation: Development. 1999 Jun;126(14):3047-55
references.pmid: 10375497
references.citation: Cancer Cell. 2007 Jan;11(1):69-82
references.pmid: 17222791
references.citation: Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11619-24
references.pmid: 10500226
references.citation: Neuroscience. 1996 Jul;73(2):581-94
references.pmid: 8783272
references.citation: Philos Trans R Soc Lond B Biol Sci. 2008 Jan 12;363(1489):123-37
references.pmid: 17322003
references.citation: Nat Neurosci. 2003 Nov;6(11):1127-34
references.pmid: 14583753
references.citation: J Cell Sci. 2001 Apr;114(Pt 7):1297-307
references.pmid: 11256996
references.citation: Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5431-6
references.pmid: 17374716
references.citation: J Neurosci. 2007 May 30;27(22):5976-80
references.pmid: 17537968
references.citation: Nat Neurosci. 2004 Nov;7(11):1233-41
references.pmid: 15494728
references.citation: Neuron. 2003 Aug 28;39(5):749-65
references.pmid: 12948443
references.citation: Prog Brain Res. 1992;91:219-33
references.pmid: 1410407
references.citation: Neuropatol Pol. 1992;30(1):73-80
references.pmid: 1484610
references.citation: Science. 2004 May 28;304(5675):1338-40
references.pmid: 15060285
references.citation: J Neurosci Methods. 2006 Mar 15;151(2):262-7
references.pmid: 16181683
references.citation: Circ Res. 1994 Mar;74(3):485-94
references.pmid: 8118957
references.citation: Neurobiol Aging. 1981 Winter;2(4):283-91
references.pmid: 7335147
references.citation: Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13883-8
references.pmid: 11095732
references.citation: Glia. 2006 Jun;53(8):799-808
references.pmid: 16541395
references.citation: J Cell Sci Suppl. 1988;10:45-62
references.pmid: 3077942
references.citation: Cell Stem Cell. 2008 Sep 11;3(3):289-300
references.pmid: 18786416
references.citation: Nature. 2004 Feb 19;427(6976):740-4
references.pmid: 14973487
references.citation: Neuron. 1999 Jun;23(2):257-71
references.pmid: 10399933
references.citation: Nature. 2006 Sep 28;443(7110):448-52
references.pmid: 16957738
references.citation: J Neurooncol. 2005 Jul;73(3):211-7
references.pmid: 15980971