Timing in cellular Ca2+ signaling.
Calcium (Ca2+) signals are generated across a broad time range. Kinetic considerations impact how information is processed to encode and decode Ca2+ signals, the choreography of responses that ensure specific and efficient signaling and the overall temporal amplification such that ephemeral Ca2+ signals have lasting physiological value. The reciprocal importance of timing for Ca2+ signaling, and Ca2+ signaling for timing is exemplified by the altered kinetic profiles of Ca2+ signals in certain diseases and the likely role of basal Ca2+ fluctuations in the perception of time itself.
Boulware
Michael J
MJ
Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA.
Marchant
Jonathan S
JS
D002118:Calcium / Q000737:chemistry; D020013:Calcium Signaling / Q000502:physiology*; D025461:Feedback, Physiological; D007700:Kinetics; D008954:Models, Biological; D013997:Time Factors
D002118:Calcium
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