[Effect of thymopentin on production of cytokines, heat shock proteins, and NF-kappaB signaling proteins].
In vivo effects of thymopentin, an active fragment of the naturally occurring thymic hormone thymopoietin, on the production of cytokines, nitric oxide, heat shock proteins, and signal proteins NF-kappaB, phNF-kappaB, and IkappaB-alpha in lymphoid cells of male NMRI mice was studied. Activation of production of several cytokines (IL-1alpha, IL-2, IL-6, IL-10, and IFN-gamma), nitric oxide, and heat shock proteins (HSP70 and HSP90) was observed in peritoneal macrophages and spleen lymphocytes of mice that received intraperitoneal injections of thymopentin (15 microg per 100 g body weight). Thymopentin apparently produces stress-like rather than damaging effects. A probable action mechanism of this hormone is activation of the NF-kappaB signaling pathway, which is most pronounced at the NF-kappaA phosphorylation stage.
Novoselova
E G
EG
Lunin
S M
SM
Khrenov
M O
MO
Cherenkov
D A
DA
Novoselova
T V
TV
Lysenko
E A
EA
Fesenko
E E
EE
D000818:Animals; D002478:Cells, Cultured; D016207:Cytokines / Q000096:biosynthesis*; D006360:Heat-Shock Proteins / Q000096:biosynthesis*; D008214:Lymphocytes / Q000187:drug effects / Q000502:physiology*; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051379:Mice; D016328:NF-kappa B; D009569:Nitric Oxide / Q000096:biosynthesis; D010766:Phosphorylation / Q000187:drug effects; D016305:Thymopentin / Q000494:pharmacology*
D016207:Cytokines; D006360:Heat-Shock Proteins; D016328:NF-kappa B; D009569:Nitric Oxide; D016305:Thymopentin