Genetic variation of Omi/HtrA2 and Parkinson's disease.
Variants in the Omi/HtrA2 gene have been nominated as a cause of Parkinson's disease. This sequencing study of Omi/HtrA2 in 95 probands with apparent autosomal dominant inheritance of Parkinson's disease did not identify any pathogenic mutations. In addition, there was no association between common variations in the Omi/HtrA2 gene and susceptibility to Parkinson's disease in any of our four patient-control series (n=2373). Taken together our results do not support a role for Omi/HtrA2 variants in the pathogenesis of Parkinson's disease.
Ross
Owen A
OA
Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, United States. ross.owen@mayo.edu
Soto
Alexandra I
AI
Vilariño-Güell
Carles
C
Heckman
Michael G
MG
Diehl
Nancy N
NN
Hulihan
Mary M
MM
Aasly
Jan O
JO
Sando
Sigrid
S
Gibson
J Mark
JM
Lynch
Timothy
T
Krygowska-Wajs
Anna
A
Opala
Grzegorz
G
Barcikowska
Maria
M
Czyzewski
Krzysztof
K
Uitti
Ryan J
RJ
Wszolek
Zbigniew K
ZK
Farrer
Matthew J
MJ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D014644:Genetic Variation / Q000235:genetics*; D000074923:High-Temperature Requirement A Serine Peptidase 2; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D024101:Mitochondrial Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D010300:Parkinson Disease / Q000235:genetics*; D012697:Serine Endopeptidases / Q000235:genetics*
D024101:Mitochondrial Proteins; D012697:Serine Endopeptidases; C000615914:HTRA2 protein, human; D000074923:High-Temperature Requirement A Serine Peptidase 2
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