title: Salmonella-containing vacuoles: directing traffic and nesting to grow.
abstract: Salmonella enterica serovar Typhimurium (S. typhimurium) is a gram-negative facultative intracellular pathogen that can infect a broad range of mammalian hosts. Following invasion of host cells, the majority of S. typhimurium are known to reside in a membrane-bound compartment known as the Salmonella-containing vacuole (SCV). S. typhimurium actively remodels this compartment using bacterial virulence proteins, called effectors, to establish a protected niche where it can replicate. S. typhimurium delivers more than 30 effectors into the host cell cytosol by bacterial type three secretion systems, encoded by Salmonella pathogenicity island 1 or 2 (SPI-1 or SPI-2). Recent studies have revealed a critical role for the SPI-1 effector SopB in 'directing traffic' at early stages of infection, allowing the bacteria to control SCV maturation by modulating its interaction with the endocytic system. At later stages of infection, the SCV establishes a 'nest' near the Golgi where optimal bacterial growth takes place. In this study, we highlight these recent developments in our understanding of SCV trafficking.
authors.affiliation: Cell Biology Program, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Malina A
authors.initials: MA
authors.lastname: Bakowski
authors.forename: Virginie
authors.initials: V
authors.lastname: Braun
authors.forename: John H
authors.initials: JH
authors.lastname: Brumell
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism; D001692:Biological Transport; D003599:Cytoskeleton / Q000378:metabolism; D004705:Endocytosis; D006801:Humans; D012475:Salmonella / Q000378:metabolism*; D014617:Vacuoles / Q000378:metabolism* / Q000382:microbiology*
chemical_list: D001426:Bacterial Proteins; C489224:SopB protein, Salmonella