Zirconocene-mediated synthesis of cyclobutabenzenes.
A new, mild, one-pot method for the synthesis of cyclobutabenzenes by the zirconium-promoted cross-coupling reaction of aryllithium compounds and alkenyl bromides is reported. Formation of an arynezirconocene complex and its regioselective coupling with an alkenyl bromide are the key steps of the process. This method allows the regio- and diastereoselective synthesis of functionalized cyclobutabenzene derivatives from simple and easily available starting materials.
Barluenga
José
J
Instituto Universitario de Química Organometálica Enrique Moles, Unidad Asociada al CSIC, Universidad de Oviedo, Julián Clavería 8, 33006-Oviedo, Spain. barluenga@uniovi.es
Calleja
Jonás
J
Antón
María J
MJ
Alvarez-Rodrigo
Lucía
L
Rodríguez
Félix
F
Fañanás
Francisco J
FJ
D001554:Benzene / Q000138:chemical synthesis* / Q000737:chemistry; D003503:Cyclobutanes / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D015040:Zirconium / Q000737:chemistry*
D003503:Cyclobutanes; D009942:Organometallic Compounds; C023398:Zirconocene dichloride; D015040:Zirconium; D001554:Benzene