Gluten ataxia.
Gluten ataxia is an immune-mediated disease triggered by the ingestion of gluten in genetically susceptible individuals. It should be considered in the differential diagnosis of all patients with idiopathic sporadic ataxia. Early diagnosis and treatment with a gluten free diet can improve ataxia and prevent its progression. Readily available and sensitive markers of gluten ataxia include antigliadin antibodies. IgA deposits against TG2 in the small bowel and at extraintestinal sites are proving to be additional reliable and perhaps more specific markers of the whole spectrum of gluten sensitivity. They may also hold the key to its pathogenesis.
Hadjivassiliou
Marios
M
Department of Neurology, The Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Trust, Sheffield, UK. m.hadjivassiliou@sheffield.ac.uk
Sanders
David S
DS
Woodroofe
Nicola
N
Williamson
Claire
C
Grünewald
Richard A
RA
D001259:Ataxia / Q000139:chemically induced* / Q000453:epidemiology; D002446:Celiac Disease / Q000453:epidemiology / Q000503:physiopathology*; D002526:Cerebellar Diseases / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology*; D000939:Epitopes / Q000032:analysis; D005983:Glutens / Q000633:toxicity*; D006801:Humans; D015995:Prevalence; D011689:Purkinje Cells / Q000187:drug effects / Q000473:pathology / Q000502:physiology
D000939:Epitopes; D005983:Glutens
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