title: Monitoring demyelination and remyelination by magnetization transfer imaging in the mouse brain at 9.4 T.
abstract: OBJECTIVE
  The aim of this study was to assess quantitatively structural changes in myelin content occurring during demyelination and remyelination by magnetization transfer imaging (MTI).
  
  
  METHODS
  In a reversible model of demyelination with no axonal loss, mice intoxicated by cuprizone were studied by MTI in vivo at 9.4 T. MRI data were compared to histopathological examinations.
  
  
  RESULTS
  Data revealed that the magnetization transfer ratio (MTR) decreased significantly during demyelination and increased during remyelination with strong correlation to the myelin content (r=0.79, P=0.01).
  
  
  CONCLUSIONS
  This study demonstrated that MTR is a sensitive and reproducible quantitative marker to assess myelin loss and repair. This may lead to in vivo monitoring of therapeutic strategies promoting remyelination.
authors.affiliation: Résonance Magnétique des Systèmes Biologiques, UMR5536 CNRS/Université Victor Segalen Bordeaux 2, 146 rue Léo Saignat Case 93, 33076, Bordeaux Cedex, France. wzaaraoui@hotmail.com
authors.forename: Wafaa
authors.initials: W
authors.lastname: Zaaraoui
authors.forename: Mathilde
authors.initials: M
authors.lastname: Deloire
authors.forename: Michel
authors.initials: M
authors.lastname: Merle
authors.forename: Céline
authors.initials: C
authors.lastname: Girard
authors.forename: Gérard
authors.initials: G
authors.lastname: Raffard
authors.forename: Marc
authors.initials: M
authors.lastname: Biran
authors.forename: Matilde
authors.initials: M
authors.lastname: Inglese
authors.forename: Klaus G
authors.initials: KG
authors.lastname: Petry
authors.forename: Oded
authors.initials: O
authors.lastname: Gonen
authors.forename: Bruno
authors.initials: B
authors.lastname: Brochet
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Franconi
authors.forename: Vincent
authors.initials: V
authors.lastname: Dousset
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D003471:Cuprizone / Q000633:toxicity; D003711:Demyelinating Diseases / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology*; D005904:Glial Fibrillary Acidic Protein; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008280:Magnetics; D051379:Mice; D008810:Mice, Inbred C57BL; D004676:Myelin Basic Protein / Q000378:metabolism; D009186:Myelin Sheath / Q000378:metabolism / Q000473:pathology*; D009419:Nerve Tissue Proteins / Q000378:metabolism
chemical_list: D005904:Glial Fibrillary Acidic Protein; D004676:Myelin Basic Protein; D009419:Nerve Tissue Proteins; C528900:glial fibrillary astrocytic protein, mouse; D003471:Cuprizone
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