Ezetimibe alone reduces low-density lipoprotein cholesterol in HIV-infected patients receiving combination antiretroviral therapy.
In this crossover study of ezetimibe monotherapy in 48 antiretroviral-treated patients with human immunodeficiency virus infection, the mean changes in low-density lipoprotein cholesterol were -5.3% (-11 mg/dL) and +5.5% (+4 mg/dL) with ezetimibe treatment and placebo, respectively (P = .04). Ezetimibe was safe and effective in reducing low-density lipoprotein cholesterol and is an option for patients who cannot tolerate treatment with a statin.
Wohl
David A
DA
University of North Carolina, Chapel Hill, NC 27599, USA. wohl@med.unc.edu
Waters
David
D
Simpson
Ross J
RJ
Richard
Susan
S
Schnell
Amanda
A
Napravnik
Sonia
S
Keys
Jessica
J
Eron
J Joseph
JJ
Hsue
Priscilla
P
D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000494:pharmacology*; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D001384:Azetidines / Q000494:pharmacology*; D008078:Cholesterol, LDL / Q000097:blood*; D000069438:Ezetimibe; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D006937:Hypercholesterolemia / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D010919:Placebos / Q000008:administration & dosage
D019380:Anti-HIV Agents; D001384:Azetidines; D008078:Cholesterol, LDL; D010919:Placebos; D000069438:Ezetimibe
HIV Med. 2005 Jan;6(1):37-44
15670251
Lancet. 2006 Aug 5;368(9534):476-82
16890834
AIDS. 2006 Nov 14;20(17):2159-64
17086055
N Engl J Med. 2006 Jan 19;354(3):251-60
16421366
PLoS Med. 2004 Oct;1(1):e19
15526045
JAMA. 2004 Jul 14;292(2):191-201
15249568
JAMA. 2001 May 16;285(19):2486-97
11368702
N Engl J Med. 2007 Apr 26;356(17):1723-35
17460226
J Am Coll Cardiol. 2004 Aug 4;44(3):720-32
15358046
N Engl J Med. 2008 Apr 3;358(14):1431-43
18376000
N Engl J Med. 2003 Nov 20;349(21):1993-2003
14627784
AIDS. 2006 Aug 1;20(12):1675-7
16868453
J Clin Endocrinol Metab. 2007 Jul;92(7):2506-12
17456578
Lipids Health Dis. 2007 Jun 13;6:15
17565701