title: Generalized sarcoidosis in two horses.
abstract: Equine sarcoidosis is a rare disorder usually characterized by exfoliative dermatitis, moderate to severe wasting, and sarcoidal granulomatous inflammation of multiple organ systems. It has an unknown aetiopathogenesis. The condition is not related to equine sarcoid. This case report describes generalized cutaneous and systemic sarcoidosis in an 11-year-old Trakehner mare (case A) and in a 7-year-old Dutch Warmblood gelding (case B). Case A was presented with cutaneous sarcoidosis on the head and body and was diagnosed on the basis of histological examination of skin. Case B presented with multiple subcutaneous nodules (2-15 cm in diameter) and the diagnosis was established at postmortem examination. Both horses showed distinctive histology of the skin with extensive lymphohistiocytic infiltration and Langhans-type multinucleated giant cells. Haematology and biochemistry revealed a normal total white blood cell count with a right shift in both horses. Case B was anaemic and had a slightly elevated total protein concentration with hyperglobulinaemia. Both horses were unresponsive to corticosteroids and were euthanized.
authors.affiliation: Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands. e.p.r.reijerkerk@uu.nl
authors.forename: E P R
authors.initials: EP
authors.lastname: Reijerkerk
authors.forename: E J B
authors.initials: EJ
authors.lastname: Veldhuis Kroeze
authors.forename: M M
authors.initials: MM
authors.lastname: Sloet van Oldruitenborgh-Oosterbaan
mesh_terms: D000818:Animals; D017809:Fatal Outcome; D005260:Female; D015743:Giant Cells, Foreign-Body / Q000473:pathology*; D015744:Giant Cells, Langhans / Q000473:pathology*; D006734:Horse Diseases / Q000175:diagnosis* / Q000473:pathology; D006736:Horses; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D012507:Sarcoidosis / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*