Desaturase activities and metabolic control in type 2 diabetes.
The aim of this study was to elucidate the effects of a poor glycemic control on fatty acid composition and desaturase activities in type 2 diabetic patients. Plasma phospholipid fatty acid composition and desaturase activities (estimated from fatty acid product to precursor ratios) were measured in 30 type 2 diabetic patients during poor metabolic control and after achieving a good metabolic control. Significant changes were recorded in the percentages of palmitic, stearic, dihomo-gamma-linolenic, docosatetraenoic and docosapentaenoic acid. The delta-5 desaturase activity was significantly higher with poor than with good metabolic control. The changes identified in plasma phospholipid fatty acid composition and the desaturase activity in type 2 diabetic patients go in the opposite direction to those described in similar conditions in type 1 diabetic patients and may be relevant to a better understanding of the role of metabolic control in the progression of chronic complications in type 2 diabetic patients.
Sartore
G
G
Department of Medical and Surgical Sciences, University of Padua, Via Dei Colli, 4, 35143 Padova, Italy. g.sartore@unipd.it
Lapolla
A
A
Reitano
R
R
Zambon
S
S
Romanato
G
G
Marin
R
R
Cosma
C
C
Manzato
E
E
Fedele
D
D
D001786:Blood Glucose / Q000187:drug effects; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D004789:Enzyme Activation; D044943:Fatty Acid Desaturases / Q000097:blood / Q000378:metabolism*; D005227:Fatty Acids / Q000097:blood; D005260:Female; D006442:Glycated Hemoglobin; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D008687:Metformin / Q000627:therapeutic use; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood; D015203:Reproducibility of Results
D001786:Blood Glucose; D044943:Fatty Acid Desaturases; D005227:Fatty Acids; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin; D008687:Metformin; D010743:Phospholipids; C517652:hemoglobin A1c protein, human