Regulation of T cell integrin function by adapter proteins.
Integrins are cell surface heterodimers that bind adhesion molecules expressed on other cells or in the extracellular matrix. Integrin-mediated interactions are critical for T cell development in the thymus, migration of T cells in the periphery, and induction of T cell effector functions. In resting T cells, integrins are maintained in a low affinity state. Engagement of the T cell receptor or chemokine receptors increases integrin affinity, enabling integrins to bind their ligands and initiate a signaling cascade resulting in altered cell morphology and motility. Our laboratory is interested how adapter proteins, mediators of intracellular signal transduction, regulate both signals from the T cell receptor to integrins (inside-out signaling) and (outside-in) signals from integrins into the cell.
Baker
Rebecca G
RG
Leonard and Madlyn Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA.
Koretzky
Gary A
GA
D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology*; D000818:Animals; D006801:Humans; D016023:Integrins / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D011948:Receptors, Antigen, T-Cell / Q000502:physiology; D019707:Receptors, Chemokine / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013601:T-Lymphocytes / Q000166:cytology / Q000378:metabolism / Q000502:physiology*
D048868:Adaptor Proteins, Signal Transducing; D016023:Integrins; D011948:Receptors, Antigen, T-Cell; D019707:Receptors, Chemokine
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