title: Effects of arginine residue introduction upon interaction and complexation behavior of peptide ribonucleic acids (PRNAs) with RNA: synthesis and properties of alpha-containing arginine.
abstract: A novel nucleic acid model using alpha-peptide ribonucleic acid (alpha-PRNA) possessing alternative alpha-PRNA/arginine sequences, where the arginine residue would be expected to stabilize the complex not only by the conventional hydrogen-bonding interactions between the complementary nucleobase pairs but also through the electrostatic interactions between positively charged side-chain groups and RNA's phosphate anions on the backbone. These alpha-PRNA form stable sequence-specific complex with the complementary RNA.
authors.affiliation: Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, Sendai, 980-8577, Miyagi, Japan. hiko@tagen.tohoku.ac.jp
authors.forename: Takehiko
authors.initials: T
authors.lastname: Wada
authors.forename: Nobuya
authors.initials: N
authors.lastname: Sawa
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Sato
authors.forename: Shiroh
authors.initials: S
authors.lastname: Futaki
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Inoue
mesh_terms: D001120:Arginine / Q000737:chemistry*; D001881:Borates / Q000737:chemistry; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry; D009691:Nucleic Acid Denaturation; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D012313:RNA / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D001881:Borates; D009841:Oligonucleotides; D010455:Peptides; D012313:RNA; D004247:DNA; D001120:Arginine