title: Angiopoietin-1 in the treatment of ischemia and sepsis.
abstract: Angiogenic factors have been the focus of a great deal of research for the treatment of ischemic diseases. Described just more than 10 years ago, angiopoietin 1 (Ang-1) has shown promising results in I/R models. Angiopoietin 1 is essential for both embryonic vasculogenesis and adult angiogenesis. Because of its role in maturation of vessels, it seems well suited to complement the angiogenic factor vascular endothelial growth factor (VEGF), which has been shown to induce vascular budding but in isolation produces nonfunctional vessels. This review will focus on (1) Ang-1 and its receptor, Tie-2, and the resultant intracellular signaling cascade; (2) the complex relationship of Ang-1 and VEGF; (3) the results of Ang-1 in I/R and sepsis models; (4) the results of combination (Ang-1 and VEGF) therapies in I/R and sepsis models; and (5) delivery mechanisms for angiogenic factors to ischemic heart.
authors.affiliation: Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors.forename: Nathan M
authors.initials: NM
authors.lastname: Novotny
authors.forename: Tim
authors.initials: T
authors.lastname: Lahm
authors.forename: Troy A
authors.initials: TA
authors.lastname: Markel
authors.forename: Paul R
authors.initials: PR
authors.lastname: Crisostomo
authors.forename: Meijing
authors.initials: M
authors.lastname: Wang
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.forename: Jiangning
authors.initials: J
authors.lastname: Tan
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Meldrum
mesh_terms: D042683:Angiopoietin-1 / Q000502:physiology / Q000627:therapeutic use*; D000818:Animals; D006801:Humans; D007511:Ischemia / Q000188:drug therapy*; D051379:Mice; D018345:Mice, Knockout; D023421:Models, Animal; D018919:Neovascularization, Physiologic; D018805:Sepsis / Q000188:drug therapy*; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology
chemical_list: C467630:ANGPT1 protein, human; D042683:Angiopoietin-1; D042461:Vascular Endothelial Growth Factor A