Exacerbation of hepatitis C induced subclinical hypoadrenalism by Interferon-alpha2beta: A case report.
Adrenal disease is an uncommon manifestation of hepatitis C infection and its related treatment regimen. This is a case of subclinical hypoadrenalism, probably induced by hepatitis C infection and further exacerbated by interferon-alpha2beta and Ribavirin therapy. The adrenal deterioration during the treatment course was observed closely with 24-hour salivary profiles and 250 mug adrenocorticotropin stimulation tests using parallel serum and salivary cortisol concentrations. A number of possible pathogenic mechanisms are discussed, and the controversy over its management is emphasized.
Tran
Huy A
HA
Department of Clinical Chemistry, Hunter Area Pathology Service, Locked Bag Number 1, Hunter Mail Region Centre, Newcastle, New South Wales 2310, Australia. huy.tran@hnehealth.nsw.gov.au.
Song
Shuzhen
S
Lojewski
Robert J
RJ
Reeves
Glenn E
GE
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