title: Effects of regular exercise on cardiovascular risk factors profile and oxidative stress in obese type 2 diabetic patients in regard to SCORE risk.
abstract: OBJECTIVE
  The aim of the present study was to investigate not only the effects of aerobic exercise on overall cardiovascular risk factors profile and oxidative stress in obese, type 2 diabetic patients, but to elucidate if those effects depended on the previously estimated Systematic Coronary Risk Evaluation (SCORE) risk.
  
  
  METHODS
  Changes in several well-established cardiovascular risk factors and oxidative stress-defense parameters were measured in a total of 30 previously sedentary, obese type 2 diabetic patients, including 16 low-risk (SCORE < 5%, aged 48.8 +/- 6.0 years, with a mean BMI of 33.28 +/- 2.94 kg/m2) and 14 high-risk (SCORE > or = 5%, aged 56.3 +/- 6.9 years, with a mean BMI of 31.40 +/- 1.13 kg/m2) patients, in regard to the SCORE model, during six months of regular aerobic exercise, performed under supervision.
  
  
  RESULTS
  Significant improvement was observed in the majority of cardiovascular risk factors, including body mass index, waist circumference, blood pressure, glycaemia, glycated haemoglobin, median blood glucose and lipid profile parameters in both diabetic subgroups during the exercise programme. However, the benefits of exercise on the majority of examined parameters became more evident in the low-risk subgroup, compared to the high-risk subgroup from baseline to 3 months. Regular exercise markedly reduced oxidative stress in both subgroups as well, as demonstrated for glutathione, plasma malondialdehyde, sulphydryl groups and catalase.
  
  
  CONCLUSIONS
  Regular aerobic exercise, performed under supervision, has many beneficial effects in improving overall cardiovascular risk factors profile and reducing oxidative stress in both low-risk and high-risk (according to SCORE model), previously sedentary and obese type 2 diabetic patients.
authors.affiliation: Clinic of Cardiovascular Diseases, Clinical Centre, Nis, Serbia.
authors.forename: Gordana
authors.initials: G
authors.lastname: Lazarevic
authors.forename: Slobodan
authors.initials: S
authors.lastname: Antic
authors.forename: Tatjana
authors.initials: T
authors.lastname: Cvetkovic
authors.forename: Vidosava
authors.initials: V
authors.lastname: Djordjevic
authors.forename: Predag
authors.initials: P
authors.lastname: Vlahovic
authors.forename: Vladisav
authors.initials: V
authors.lastname: Stefanovic
mesh_terms: D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control; D048909:Diabetes Complications / Q000378:metabolism / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism / Q000503:physiopathology* / Q000517:prevention & control; D015444:Exercise; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D009765:Obesity / Q000503:physiopathology*; D018384:Oxidative Stress; D010865:Pilot Projects; D018570:Risk Assessment; D012307:Risk Factors