Multiple changes in sialic acid biology during human evolution.
Humans are genetically very similar to "great apes", (chimpanzees, bonobos, gorillas and orangutans), our closest evolutionary relatives. We have discovered multiple genetic and biochemical differences between humans and these other hominids, in relation to sialic acids and in Siglecs (Sia-recognizing Ig superfamily lectins). An inactivating mutation in the CMAH gene eliminated human expression of N-glycolylneuraminic acid (Neu5Gc) a major sialic acid in "great apes". Additional human-specific changes have been found, affecting at least 10 of the <60 genes known to be involved in the biology of sialic acids. There are potential implications for unique features of humans, as well as for human susceptibility or resistance to disease. Additionally, metabolic incorporation of Neu5Gc from animal-derived materials occurs into biotherapeutic molecules and cellular preparations--and into human tissues from dietary sources, particularly red meat and milk products. As humans also have varying and sometime high levels of circulating anti-Neu5Gc antibodies, there are implications for biotechnology products, and for some human diseases associated with chronic inflammation.
Varki
Ajit
A
Center for Academic Research and Training in Anthropogeny, Department of Medicine, University of California, San Diego, 9500 Gilman Dr MC 0687, La Jolla, CA 92093-0687, USA. a1varki@ucsd.edu
D000818:Animals; D005075:Biological Evolution; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism; D009154:Mutation / Q000235:genetics; D019158:N-Acetylneuraminic Acid / Q000378:metabolism*; D009438:Neuraminic Acids / Q000378:metabolism; D011971:Receptors, Immunologic / Q000378:metabolism; D063267:Sialic Acid Binding Ig-like Lectin 1; D013045:Species Specificity
D008562:Membrane Glycoproteins; D009438:Neuraminic Acids; D011971:Receptors, Immunologic; C571166:SIGLEC1 protein, human; D063267:Sialic Acid Binding Ig-like Lectin 1; C032592:N-glycolylneuraminic acid; D019158:N-Acetylneuraminic Acid
Mol Cell Biol. 2007 Jun;27(12):4340-6
17420276
Nature. 2002 Dec 19-26;420(6917):860-7
12490959
J Biol Chem. 1989 Dec 5;264(34):20216-23
2684973
Int J Cancer. 2000 May 1;86(3):425-8
10760833
Anal Biochem. 2007 May 1;364(1):8-18
17362871
Zoology (Jena). 2004;107(1):49-64
16351927
Nephron. 1996;72(4):599-603
8730428
Jpn J Cancer Res. 1987 Jun;78(6):614-20
3112076
Int J Cancer. 2004 Jun 20;110(3):424-8
15095309
Ann N Y Acad Sci. 1963 Mar 30;106:202-17
13964994
Virology. 1983 Jun;127(2):361-73
6868370
Eur J Biochem. 1994 Feb 1;219(3):1001-11
8112313
Int Arch Allergy Appl Immunol. 1988;85(3):381-3
3258290
Glycoconj J. 1994 Dec;11(6):576-85
7696861
Cancer. 1986 Dec 1;58(11):2363-71
3768832
Genome Res. 2000 Aug;10(8):1065-70
10958623
J Immunol. 1982 Dec;129(6):2524-8
6183336
Mol Microbiol. 2003 Sep;49(5):1213-25
12940982
EMBO J. 1991 Jul;10(7):1661-9
2050106
J Biol Chem. 2003 Nov 28;278(48):48245-50
14500706
Eur J Biochem. 2003 Mar;270(5):950-61
12603328
Arterioscler Thromb Vasc Biol. 2007 May;27(5):1087-94
17442899
J Immunol. 1979 Jun;122(6):2314-8
109527
Science. 2007 Jan 26;315(5811):450-2
17255486
Nature. 2008 May 15;453(7193):314-21
18480812
Oncologist. 2000;5(5):393-404
11040276
Wound Repair Regen. 2001 Mar-Apr;9(2):66-76
11350644
Am J Phys Anthropol. 1998 Oct;107(2):187-98
9786333
Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12819-24
16126901
Glycobiology. 2007 Aug;17(8):838-46
17483134
Science. 2006 Apr 21;312(5772):404-10
16543414
Nat Rev Genet. 2003 Jan;4(1):20-8
12509750
J Clin Oncol. 2006 Sep 10;24(26):4356-65
16963733
Blood. 1998 Sep 15;92(6):2123-32
9731071
Mol Cell Biol. 2007 Apr;27(8):3008-22
17296732
PLoS One. 2008 Apr 16;3(4):e1967
18414664
Hoppe Seylers Z Physiol Chem. 1970 Jul;351(7):783-91
4317421
Am J Clin Nutr. 1999 Sep;70(3 Suppl):532S-538S
10479227
Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11736-41
12192086
J Biotechnol. 2005 Apr 20;117(1):57-72
15831248
J Immunol. 2005 Jul 1;175(1):228-36
15972653
Nature. 2005 Sep 1;437(7055):27-9
16136111
Glycobiology. 2007 May;17(5):23R-34R
17237137
J Biol Chem. 2006 Sep 1;281(35):25689-702
16769723
Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12045-50
14523234
J Biol Chem. 1989 Jul 5;264(19):10931-4
2738054
J Neurol Sci. 2002 Oct 15;202(1-2):13-23
12220687
Int Arch Allergy Appl Immunol. 1991;95(2-3):231-5
1937925
Genetics. 2006 Feb;172(2):1139-46
16272417
Acta Histochem Suppl. 1990;40:35-8
2091044
Anal Biochem. 2006 Feb 15;349(2):197-207
16360109
J Biol Chem. 2002 Sep 6;277(36):32930-8
12068010
J Biol Chem. 2001 Oct 26;276(43):40282-7
11546777
FEBS Lett. 1990 Nov 26;275(1-2):9-14
2124546
J Biol Chem. 1999 Aug 6;274(32):22729-38
10428856
J Biol Chem. 1995 Jul 7;270(27):16458-63
7608218
Curr Opin Chem Biol. 2007 Aug;11(4):373-80
17681848
J Biol Chem. 2000 Mar 24;275(12):8633-40
10722703
Arch Biochem Biophys. 1989 Apr;270(1):391-7
2648997
J Virol. 2007 Dec;81(23):12846-58
17855525
Biochem Biophys Res Commun. 1977 Nov 21;79(2):388-95
412499
J Biochem. 1986 Aug;100(2):469-75
3491066
Genome Res. 2005 Dec;15(12):1746-58
16339373
EMBO J. 1994 Oct 3;13(19):4490-503
7925291
Proc Natl Acad Sci U S A. 2006 May 16;103(20):7765-70
16682635
Acta Biochim Pol. 2003;50(4):1205-11
14740007
Stem Cells. 2007 Jan;25(1):197-202
17008421
J Clin Microbiol. 1982 Apr;15(4):610-6
6279695
J Clin Invest. 1936 Nov;15(6):591-9
16694432
J Biol Chem. 2002 Jul 5;277(27):24466-74
11986327
Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):11123-8
15263085
Xenotransplantation. 2002 Nov;9(6):376-81
12371933
Glycobiology. 2007 Sep;17(9):922-31
17580316
Immunology. 1999 Oct;98(2):213-9
10610356
Cell. 2006 Sep 8;126(5):855-67
16959566
Adv Parasitol. 2003;54:255-80
14711087
J Biol Chem. 1981 Aug 25;256(16):8357-63
6167577
Pain. 1985 Apr;21(4):315-327
3923417
Cancer Res. 1985 Aug;45(8):3796-802
3874688
Chem Rev. 2002 Feb;102(2):439-69
11841250
Annu Rev Biochem. 2004;73:491-537
15189151
J Chromatogr A. 2007 Aug 10;1160(1-2):263-9
17570377
Biochimie. 2001 Jul;83(7):623-34
11522391
Immunol Lett. 1992 Mar;32(1):91-6
1379980
J Biol Chem. 2005 Feb 11;280(6):4228-37
15557321
Am J Clin Nutr. 2005 May;81(5):1147-54
15883441
J Biol Chem. 1993 Apr 5;268(10):7019-27
8463235
Nutr Cancer. 2005;53(1):65-72
16351508
Nature. 2008 Jul 24;454(7203):436-44
18650914
J Leukoc Biol. 2004 Mar;75(3):388-97
14612429
Nature. 1957 May 25;179(4569):1088
13430805
Arch Biochem Biophys. 2004 Jun 15;426(2):163-72
15158667
Cell. 2006 Sep 8;126(5):841-5
16959563
Glycobiology. 2008 Oct;18(10):818-30
18669916
J Clin Lab Immunol. 1996;48(2):75-85
16296265
Eur J Immunol. 2008 Aug;38(8):2303-15
18629938
Curr Opin Immunol. 2007 Apr;19(2):209-16
17276050
Mol Immunol. 1986 Jun;23(6):631-8
3092032
J Biochem. 1994 Mar;115(3):381-6
8056746
J Virol. 2008 Oct;82(20):10271-8
18667496
Glycobiology. 2000 May;10(5):477-86
10764836
J Biol Chem. 2002 Nov 29;277(48):45719-28
12235148
FASEB J. 2006 Oct;20(12):1964-73
17012248
Blood. 2001 Jan 1;97(1):288-96
11133773
Int Arch Allergy Appl Immunol. 1986;81(3):204-8
3095247
Glycobiology. 2004 Apr;14(4):339-46
14693915
PLoS One. 2007 Feb 28;2(2):e257
17330143
Nature. 2005 Jun 9;435(7043):752-3
15944689
Am J Phys Anthropol. 2001;Suppl 33:54-69
11786991
Int Arch Allergy Appl Immunol. 1990;91(3):323-8
2354874
Nature. 2007 Apr 26;446(7139):1023-9
17460663
Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13251-6
15331780
Nat Rev Genet. 2006 Jul;7(7):537-51
16755287
Glycobiology. 1999 Aug;9(8):747-55
10406840
Atherosclerosis. 1996 Aug 23;125(1):81-9
8831930
Cell Mol Life Sci. 2006 Jun;63(12):1331-54
16596337
Glycoconj J. 2006 Feb;23(1-2):51-8
16575522
Glycobiology. 2006 Jan;16(1):1R-27R
16014749
J Natl Cancer Inst. 1993 Oct 6;85(19):1571-9
8105097
Eur J Biochem. 1992 May 15;206(1):269-77
1587278
Arterioscler Thromb Vasc Biol. 1996 Dec;16(12):1573-9
8977464
Cancer Res. 2006 Mar 15;66(6):2937-45
16540641
Science. 2005 Sep 9;309(5741):1693
16151003
Nat Rev Microbiol. 2004 Jan;2(1):15-22
15035005
Science. 2001 Jul 20;293(5529):482-4
11463913
Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11751-6
9751737
Microbiol Mol Biol Rev. 2004 Mar;68(1):132-53
15007099
Clin Exp Immunol. 1984 May;56(2):345-52
6375917
J Biol Chem. 1989 Oct 25;264(30):17615-8
2681181
Cancer Res. 1991 Nov 1;51(21):5826-36
1718585
J Immunol. 1997 Mar 15;158(6):2964-76
9058836
Hoppe Seylers Z Physiol Chem. 1969 Feb;350(2):155-62
5776501
Biol Chem Hoppe Seyler. 1988 Jun;369(6):477-86
3202954
J Bacteriol. 2007 Feb;189(4):1231-7
16997964
J Biochem. 1991 Sep;110(3):429-35
1769971
Nat Rev Immunol. 2007 Apr;7(4):255-66
17380156
Cytogenet Cell Genet. 1997;78(3-4):295-300
9465907
Neurosci Lett. 2005 Jan 10;373(2):159-64
15567573
J Biol Chem. 1998 Jun 19;273(25):15866-71
9624188
Trends Genet. 2003 Dec;19(12):671-4
14642743
Nature. 2008 Jul 3;454(7200):21-3
18596780
Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11399-404
11562455
Int J Cancer. 2002 Mar 10;98(2):241-56
11857415
Nat Med. 2005 Feb;11(2):228-32
15685172
Int Arch Allergy Appl Immunol. 1978;57(5):477-80
78906