title: Xanthine oxidase activity in patients with sepsis.
abstract: OBJECTIVE
  Determine the relation of xanthine oxidase (XO) activity and the outcome of septic patients and its relation to oxidative damage and clinical parameters of sepsis severity.
  
  
  METHODS
  Patients admitted over a 6-month period were enrolled. Patients were assigned to groups according to the diagnosis of sepsis (n=8), severe sepsis (n=28) or septic shock (n=36). Blood samples were collected to the determination of thiobarbituric acid reactive species (TBARS), protein carbonyls and XO activity.
  
  
  RESULTS
  None of the studied oxidative parameters determined at the time of diagnosis were related to sepsis severity. XO activity, but not oxidative damage parameters, at the time of sepsis diagnosis was significantly higher in non-survival septic patients. In contrast, 24 h after sepsis diagnosis, XO activity was lower in non-survivors septic patients.
  
  
  CONCLUSIONS
  XO activity was increased in non-survivors patients and the variations in XO activity could be used for outcome prediction.
authors.affiliation: Laboratório de Fisiopatologia Experimental, Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil.
authors.forename: Marilene N
authors.initials: MN
authors.lastname: Luchtemberg
authors.forename: Fabricia
authors.initials: F
authors.lastname: Petronilho
authors.forename: Larissa
authors.initials: L
authors.lastname: Constantino
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Gelain
authors.forename: Michael
authors.initials: M
authors.lastname: Andrades
authors.forename: Cristiane
authors.initials: C
authors.lastname: Ritter
authors.forename: José Cláudio F
authors.initials: JC
authors.lastname: Moreira
authors.forename: Emilio L
authors.initials: EL
authors.lastname: Streck
authors.forename: Felipe
authors.initials: F
authors.lastname: Dal-Pizzol
mesh_terms: D018806:APACHE; D003710:Demography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D050050:Protein Carbonylation; D012372:ROC Curve; D018805:Sepsis / Q000175:diagnosis / Q000201:enzymology* / Q000401:mortality; D012720:Severity of Illness Index; D016019:Survival Analysis; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014969:Xanthine Oxidase / Q000378:metabolism*
chemical_list: D017392:Thiobarbituric Acid Reactive Substances; D014969:Xanthine Oxidase