title: Hepatoprotective effects of setarud against carbon tetrachloride-induced liver injury in rats.
abstract: To assess the hepatoprotective activity of a new herbal drug "setarud" in experimental liver fibrosis, 48 male Wistar rats were divided into four groups: controls, carbon tetrachloride (CCl4) group, and two treatment groups that received CCl4 and setarud at doses of 0.02 or 0.04 g/Kg/day for 30 days. Body weight gain, biochemical liver tests, bile flow rate and composition, and changes in liver morphology in the four groups were studied. CCl4 administration led to morphological and biochemical evidence of liver injury as compared to untreated controls. Setarud administration led to significant protection against CCl4-induced changes in body weight gain, liver morphology, bile flow and concentration. It was also associated with significantly lower serum liver enzyme levels (p<0.01), higher serum albumin level, and reduced increase in narcotic-induced sleeping time. Thus, setarud showed protective activity against CCl4-induced hepatotoxicity in rats. Further studies of its efficacy in liver disease are warranted.
authors.affiliation: Genetic Research Centre, Social Welfare and Rehabilitation Sciences University, Tehran, Iran. khorshidhamidreza@yahoo.com
authors.forename: Hamid Reza Khorram
authors.initials: HR
authors.lastname: Khorshid
authors.forename: Jahan A
authors.initials: JA
authors.lastname: Azonov
authors.forename: Yury A
authors.initials: YA
authors.lastname: Novitsky
authors.forename: Bardia
authors.initials: B
authors.lastname: Farzamfar
authors.forename: Mohammad Hassan
authors.initials: MH
authors.lastname: Shahhosseiny
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002251:Carbon Tetrachloride; D004195:Disease Models, Animal; D008103:Liver Cirrhosis / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D027826:Rosa; D012643:Selenium / Q000627:therapeutic use; D031203:Tanacetum; D026982:Urtica dioica
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; C555145:setarud; D002251:Carbon Tetrachloride; D012643:Selenium