Crown ether ring-fused nucleosides: synthesis and conformational properties.
We here describe the synthesis of a series of novel bicyclic ribonucleoside derivatives, with 18-crown-6 ether moieties attached via their ribose 2- and 3- positions, as first examples of crown ether ring-fused nucleosides, to be evaluated as antiviral and/or antitumoral agents.
Coppola
Cinzia
C
Dipartimento di Chimica Organica e Biochimica, Università degli Studi di Napoli Federico II, Complesso Universitario di Monte S. Angelo, via Cinthia, Napoli, Italy.
D'Onofrio
Jennifer
J
Di Fabio
Giovanni
G
De Napoli
Lorenzo
L
Montesarchio
Daniela
D
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry; D043844:Crown Ethers / Q000138:chemical synthesis* / Q000737:chemistry; D009690:Nucleic Acid Conformation; D012263:Ribonucleosides / Q000138:chemical synthesis* / Q000737:chemistry
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D043844:Crown Ethers; D012263:Ribonucleosides