Role of ischemia modified albumin to ST-segment resolution after mechanical reperfusion in patients with ST-segment elevation myocardial infarction.
OBJECTIVE
To investigate the possible association between admission ischemia modified albumin (IMA) levels and ST-segment resolution (STR) in ST-segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PCI).


METHODS
We studied 117 patients with a first STEMI within 6h of the onset of pain. Admission serum IMA concentration was measured using a validated assay. The worst single electrocardiogram lead before and 90min after primary PCI was analyzed, and patients were divided into two groups according to the degree of STR: complete (> or =70%) or incomplete (<70%).


RESULTS
Of the 117 patients, 70 (60%) had complete STR, and 47 (40%) incomplete STR. Serum IMA concentrations were significantly higher in patients that had incomplete STR (0.383+/-0.060A.U. vs. 0.297+/-0.056A.U., p<0.001). IMA levels >0.325A.U. demonstrated a sensitivity of 91.4% and a specificity of 45.7% for the diagnosis of incomplete STR; the area under the receiver operator characteristic curve was 0.849 (95% CI 0.77-0.92, p=0.0001). Moreover, IMA values were an independent predictor of incomplete STR even after adjustment for potential confounders (OR 2.34; 95% CI 1.20-4.64, p=0.01).


CONCLUSIONS
IMA may be a useful biomarker for the identification of incomplete STR in STEMI patients presenting to hospital within 6h of the onset of pain.
Dominguez-Rodriguez
Alberto
A
Department of Cardiology, University Hospital of Canarias, Tenerife, Spain. adrvdg@hotmail.com
Kaski
Juan Carlos
JC
Abreu-Gonzalez
Pedro
P
Samimi-Fard
Sima
S
D000368:Aged; D000418:Albumins / Q000378:metabolism*; D015906:Angioplasty, Balloon, Coronary / Q000379:methods; D015415:Biomarkers / Q000378:metabolism; D004562:Electrocardiography / Q000379:methods; D005260:Female; D006801:Humans; D007511:Ischemia / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000628:therapy*; D012372:ROC Curve; D015424:Reperfusion; D012680:Sensitivity and Specificity; D013997:Time Factors; D016896:Treatment Outcome
D000418:Albumins; D015415:Biomarkers