MicroRNA in the ovary and female reproductive tract.
Posttranscriptional gene regulation plays a vital role in male and female germ cell function, but our understanding of this regulatory process in somatic cells and its effect on reproductive tissue development and function is not understood. In mammalian cells, microRNA (miRNA) are key posttranscriptional regulators and function by modulating translation or degradation of their target mRNA. Mature miRNA are synthesized through a multi-step process that concludes with the cleavage of stem-loop pre-miRNA by the RNase III enzyme, Dicer1. To determine the extent of miRNA regulation and establish a baseline, miRNA profiling has indicated the presence of large numbers of miRNA within reproductive tissues and cells. Moreover, several studies have indicated that miRNA expression in reproductive tissues varies in response to pituitary and gonadal hormones. To understand the role that miRNA-mediated posttranscriptional gene regulation plays in female reproduction, a global Dicer1 hypomorph mouse and several tissue-specific Dicer1 knockout mice have been studied. Interestingly, when Dicer1 expression is decreased in reproductive tissues or cells, the females are infertile. This review discusses all the work regarding miRNA regulation within the mammalian female reproductive system published to date.
Carletti
M Z
MZ
Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City 66160, USA.
Christenson
L K
LK
D000818:Animals; D005260:Female; D005831:Genital Diseases, Female / Q000378:metabolism / Q000662:veterinary*; D005836:Genitalia, Female / Q000378:metabolism*; D035683:MicroRNAs / Q000096:biosynthesis / Q000378:metabolism; D015053:Zygote / Q000378:metabolism
D035683:MicroRNAs
Science. 2001 May 4;292(5518):929-34
11340206
Dev Biol. 2007 Jul 15;307(2):227-36
17532316
Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10898-903
16040801
Nat Neurosci. 2007 Dec;10(12):1513-4
17994015
Biochem Biophys Res Commun. 2007 Jan 5;352(1):231-6
17113034
J Biol Chem. 2008 Jun 27;283(26):18158-66
18456660
Mol Cancer Res. 2008 Apr;6(4):663-73
18403645
J Biol Chem. 2008 Aug 22;283(34):23473-84
18556655
Nat Rev Mol Cell Biol. 2008 Jan;9(1):22-32
18073770
Dev Biol. 1993 Apr;156(2):552-6
8462750
Biol Reprod. 2006 Dec;75(6):877-84
16943360
RNA. 2005 Sep;11(9):1461-70
16043497
Genes Chromosomes Cancer. 2007 Apr;46(4):336-47
17243163
Genes Dev. 2007 Mar 15;21(6):644-8
17369397
Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16426-31
16260724
Physiol Genomics. 2007 Mar 14;29(1):35-43
17105755
Cancer Res. 2008 Jan 15;68(2):425-33
18199536
Clin Cancer Res. 2008 May 1;14(9):2690-5
18451233
Endocrinology. 2004 Apr;145(4):1617-24
14684606
Biol Reprod. 2008 Dec;79(6):1030-7
18716288
Immunity. 2007 Jul;27(1):123-34
17613256
Genome Biol. 2008;9(8):R127
18700987
Fertil Steril. 2008 Jun;89(6):1771-6
17765232
Cancer Res. 2007 Sep 15;67(18):8433-8
17823410
Genes Dev. 2007 Mar 15;21(6):682-93
17369401
Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15144-9
17848513
Endocrinology. 2005 Jan;146(1):423-31
15459111
Blood. 2007 Aug 15;110(4):1330-3
17496199
Nature. 2004 May 13;429(6988):154
15141202
Genome. 2006 Oct;49(10):1283-6
17213910
Genome Res. 2006 Oct;16(10):1289-98
16954537
J Biol Chem. 2008 Jan 18;283(3):1764-1772
18029355
Cancer Res. 2007 Sep 15;67(18):8699-707
17875710
Nat Struct Mol Biol. 2008 Mar;15(3):268-79
18311151
BMC Med. 2008 Jun 24;6:14
18577219
Sci STKE. 2007 Jan 02;2007(367):re1
17200520
Oncogene. 2008 Apr 3;27(15):2128-36
17968323
Mol Cell Biol. 1999 Mar;19(3):1720-30
10022859
RNA. 2007 Dec;13(12):2366-80
17951331
Dev Biol. 1988 Oct;129(2):304-14
2458285
Nat Genet. 2002 Nov;32(3):408-10
12368913
Endocrinology. 2008 Dec;149(12):6207-12
18703631
PLoS One. 2008 Jun 18;3(6):e2436
18560586
Curr Top Microbiol Immunol. 2001;259:77-93
11417128
Development. 1998 Aug;125(16):3201-11
9671592
Dev Biol. 2005 Dec 1;288(1):276-83
16256976
Cancer Res. 2008 Apr 15;68(8):2773-80
18413744
Mol Cell. 2007 Oct 26;28(2):328-36
17964270
Mol Cell Endocrinol. 2005 Apr 29;234(1-2):19-25
15836949
Cancer Res. 2007 Jul 1;67(13):6092-9
17616664
Cell. 2005 Jan 14;120(1):15-20
15652477
Proc Natl Acad Sci U S A. 2008 May 13;105(19):7004-9
18458333
Science. 2006 Apr 7;312(5770):75-9
16484454
Gynecol Oncol. 2008 Aug;110(2):206-15
18499237
Biol Reprod. 2007 Aug;77(2):312-9
17494914
J Biol Chem. 2005 Mar 11;280(10):9330-5
15613470
Proc Natl Acad Sci U S A. 2007 Nov 6;104(45):17719-24
17965236
Mol Hum Reprod. 2007 Nov;13(11):797-806
17766684
Science. 2007 Dec 21;318(5858):1931-4
18048652
Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8680-5
11438698
Nature. 2008 Jul 3;454(7200):56-61
18548003
J Biol Chem. 2008 Mar 14;283(11):6925-34
18184656
J Clin Invest. 2008 May;118(5):1944-54
18398510
Nat Genet. 2003 Nov;35(3):215-7
14528307
Cell. 2005 Jan 14;120(1):21-4
15652478
Nature. 2007 Jun 14;447(7146):823-8
17507929
RNA. 2004 Dec;10(12):1957-66
15525708
J Biol Chem. 2008 Apr 11;283(15):9505-8
18272516
FEBS Lett. 2008 Jun 18;582(14):1977-86
18342629
Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7018-24
11416181
Hum Reprod Update. 2002 Jan-Feb;8(1):21-41
11866238