title: Chemiluminescence method for the determination of piroxicam by the enhancement of the tris-(4,7-diphenyl-1,10-phenanthrolinedisulphonic acid) ruthenium(II) (RuBPS)-cerium(IV) system and its application.
abstract: A simple, rapid chemiluminescence (CL) method was described for the determination of piroxicam, a commonly used analgesic agent drug. A strong CL signal was detected when cerium(IV) sulphate was injected into tris-(4,7-diphenyl-1,10-phenanthrolinedisulphonic acid) ruthenium(II) (RuBPS)-piroxicam solution. The CL signal was proportional to the concentration of piroxicam in the range 2.8 x 10(-8)-1.2 x 10(-5) mol/L. The detection limit was 2 x 10(-8) mol/L and the relative standard deviation (RSD) was 3.7% (c = 7.0 x 10(-7) mol/L piroxicam; n = 11). The proposed method was applied to the determination of piroxicam in pharmaceutical preparations in capsules, spiked serum and urine samples with satisfactory results.
authors.affiliation: Department of Chemistry, Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, Huazhong University of Science and Technology, Wuhan 430074, People's Republic of China.
authors.forename: Fengshan
authors.initials: F
authors.lastname: Yu
authors.forename: Yangbin
authors.initials: Y
authors.lastname: Zhang
authors.forename: Fang
authors.initials: F
authors.lastname: Chen
authors.forename: Lanhua
authors.initials: L
authors.lastname: Chen
mesh_terms: D002563:Cerium / Q000737:chemistry*; D006801:Humans; D007700:Kinetics; D008163:Luminescent Measurements / Q000379:methods*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010618:Phenanthrolines / Q000737:chemistry*; D010894:Piroxicam / Q000032:analysis* / Q000737:chemistry*; D013431:Sulfates / Q000737:chemistry*; D013997:Time Factors
chemical_list: D009942:Organometallic Compounds; D010618:Phenanthrolines; D013431:Sulfates; C518776:ruthenium II tris (bathophenanthroline disulfonate); D010894:Piroxicam; C107379:cerium sulfate; D002563:Cerium