Voriconazole-induced photosensitivity.
Voriconazole is a broad-spectrum triazole antifungal agent indicated for invasive aspergillosis, refractory Candida infections, and other emerging invasive fungal infections. Adverse cutaneous reactions associated with voriconazole therapy occur in fewer than 10% of treated patients and range from mild erythematous eruptions to life-threatening reactions such as the Stevens-Johnson syndrome and toxic epidermal necrolysis. Photosensitivity reactions are an uncommon but characteristic dermatitis in voriconazole recipients, particularly following chronic administration. We report a case of voriconazole-induced phototoxicity in a 50-year-old male with Candida parapsilosis endocarditis that reversed on discontinuation of the drug.
Malani
Anurag N
AN
Division of Infectious Diseases, St. Joseph Mercy Hospital, 5333 McAuley Dr Suite 3106, Ypsilanti, MI 48197, USA. malanian@umich.edu
Aronoff
David M
DM
D000935:Antifungal Agents / Q000009:adverse effects*; D002177:Candidiasis / Q000188:drug therapy; D004696:Endocarditis / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010787:Photosensitivity Disorders / Q000139:chemically induced* / Q000473:pathology; D011743:Pyrimidines / Q000009:adverse effects*; D014230:Triazoles / Q000009:adverse effects*; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole
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