title: Differential diagnosis of lipoma-like lipoblastoma.
abstract: Lipoblastomas are rare benign tumors of white fatty tissue that occur primarily in young children. Occasionally, heterogeneity of morphological appearance and histological overlap with other lipogenic tumors are described. In such cases fluorescence in situ hybridization (FISH) analysis of PLAG1, a gene specifically rearranged in lipoblastoma, is necessary to prevent misdiagnosis. We present a case of lipoblastoma arising in an atypical site with histological features characteristic of lipoma. The correct diagnosis was made possible on cytogenetic grounds through the identification of the characteristic PLAG1-HAS2 fusion gene, thus allowing an appropriate clinical approach.
authors.affiliation: Department of Pediatric Hematology/Oncology, Giannina Gaslini Institute, Genova, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Morerio
authors.forename: Paolo
authors.initials: P
authors.lastname: Nozza
authors.forename: Elisa
authors.initials: E
authors.lastname: Tassano
authors.forename: Cristina
authors.initials: C
authors.lastname: Rosanda
authors.forename: Claudio
authors.initials: C
authors.lastname: Granata
authors.forename: Massimo
authors.initials: M
authors.lastname: Conte
authors.forename: Claudio
authors.initials: C
authors.lastname: Panarello
mesh_terms: D002675:Child, Preschool; D004268:DNA-Binding Proteins / Q000032:analysis / Q000235:genetics; D003937:Diagnosis, Differential; D005260:Female; D014453:Glucuronosyltransferase / Q000032:analysis / Q000235:genetics; D006801:Humans; D000076002:Hyaluronan Synthases; D017404:In Situ Hybridization, Fluorescence; D008067:Lipoma / Q000175:diagnosis*; D018205:Neoplasms, Adipose Tissue / Q000175:diagnosis*; D015514:Oncogene Proteins, Fusion / Q000032:analysis
chemical_list: D004268:DNA-Binding Proteins; D015514:Oncogene Proteins, Fusion; C104382:PLAG1 protein, human; D014453:Glucuronosyltransferase; C101754:HAS2 protein, human; D000076002:Hyaluronan Synthases