Prolonged 5-HT1A/5-HT2A receptor cross-talk is absent prior to adulthood in rats.
In adult rats, serotonin 1A (5-HT1A) receptor activation produces heterologous desensitization of serotonin 2A (5-HT2A) neuroendocrine function at 1 h that persists up to 72 h. This study determined whether prolonged 5-HT1A/5-HT2A cross-talk exists before sexual maturation. Adolescent male rats (postnatal day 39) received an injection with saline or (+)-8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide [(+)8-OH-DPAT] 24 h before receiving a challenge injection of saline, (+)-8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide, or (-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl [(-)DOI] o assess changes in basal, 5-HT1A, and 5-HT2A receptor-mediated hormone responses. Although homologous desensitization of 5-HT1A neuroendocrine responses was present at 24 h, heterologous desensitization of 5-HT2A neuroendocrine responses was not. These data suggest that 5-HT1A heterologous desensitization of 5-HT2A receptor function does not develop until adulthood, is more transient, or follows a different time course before maturation.
Petrunich
Maureen L
ML
Neuroscience Institute, Loyola University Chicago, Maywood, Illinois, USA.
Garcia
Francisca
F
Carrasco
Gonzalo A
GA
Battaglia
George
G
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000008:administration & dosage / Q000494:pharmacology; D000324:Adrenocorticotropic Hormone / Q000097:blood* / Q000378:metabolism; D000367:Age Factors; D000704:Analysis of Variance; D000818:Animals; D007215:Indophenol / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D007279:Injections, Subcutaneous; D008297:Male; D010121:Oxytocin / Q000097:blood* / Q000378:metabolism; D011863:Radioimmunoassay; D051381:Rats; D017207:Rats, Sprague-Dawley; D020239:Receptor Cross-Talk / Q000187:drug effects / Q000502:physiology*; D044282:Receptor, Serotonin, 5-HT1A / Q000502:physiology*; D044402:Receptor, Serotonin, 5-HT2A / Q000502:physiology*; D017366:Serotonin Receptor Agonists / Q000008:administration & dosage / Q000494:pharmacology; D013997:Time Factors
D044402:Receptor, Serotonin, 5-HT2A; D017366:Serotonin Receptor Agonists; C113896:dimethoxy-4-indophenyl-2-aminopropane; D044282:Receptor, Serotonin, 5-HT1A; D010121:Oxytocin; D007215:Indophenol; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000324:Adrenocorticotropic Hormone