Focal nodular hyperplasia-like lesion of the liver in a child previously treated for nephroblastoma.
Described herein is the case of an 8-year-old boy who developed a hepatic nodular lesion after having received anti-neoplastic therapy for nephroblastoma. Histological examination of the excised specimen indicated a disordered arrangement of hepatic components with hemangioma-like features. This case was diagnosed as a variant of focal nodular hyperplasia. It is speculated that this hepatic lesion is a late complication of treatment for nephroblastoma and might develop from congenital malformative area of the liver.
Takeyama
Junji
J
Department of Pathology, Miyagi Children's Hospital, Sendai, Japan. jtakeyama@yahoo.co.jp
Ando
Ryo
R
Sato
Tomoyuki
T
Nio
Masaki
M
Shimanuki
Yoshihisa
Y
Sato
Atsushi
A
Imaizumi
Masue
M
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury; D002648:Child; D003131:Combined Modality Therapy; D003609:Dactinomycin / Q000008:administration & dosage; D020518:Focal Nodular Hyperplasia / Q000139:chemically induced*; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D009392:Nephrectomy; D014750:Vincristine / Q000008:administration & dosage; D009396:Wilms Tumor / Q000188:drug therapy*
D003609:Dactinomycin; D014750:Vincristine