title: [A case of advanced gastric cancer with giant lymph node metastasis responding to S-1/CDDP neoadjuvant chemotherapy].
abstract: The patient was a 66-year-old man with advanced gastric cancer and bulky lymph node metastases. Since a radical resection appeared impossible, we tried neoadjuvant chemotherapy (NAC) with S-1/CDDP, expecting down staging of the tumor. S-1 (120 mg/body) was orally administered for 21 days and CDDP (40 mg/body) was administered by intravenous drip on day 8, 15 and 22. Partial response (PR) was obtained after 2 courses, and distal gastrectomy with D2 lymph node dissection was performed. The histological diagnosis revealed complete disappearance of cancer cells in stomach and a few regional lymph node metastasis (3/30). The patient was administered S-1 for one year after operation, and he is well without recurrence at one year and four months postoperatively. We considered the S-1 and CDDP in combination useful as preoperative chemotherapy for advanced gastric cancer.
authors.affiliation: Dept. of Surgery, Omuta City General Hospital.
authors.forename: Satoru
authors.initials: S
authors.lastname: Matono
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Horiuchi
authors.forename: Yukiya
authors.initials: Y
authors.lastname: Kishimoto
authors.forename: Hiroko
authors.initials: H
authors.lastname: Sasahara
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Ureshino
authors.forename: Masaki
authors.initials: M
authors.lastname: Kashihara
authors.forename: Susumu
authors.initials: S
authors.lastname: Sueyoshi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Shirouzu
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000097:blood; D002945:Cisplatin / Q000627:therapeutic use*; D004338:Drug Combinations; D005773:Gastroscopy; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D010094:Oxonic Acid / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D005641:Tegafur / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin