title: Gene admixture in ethnic populations in upper part of Silk Road revealed by mtDNA polymorphism.
abstract: To evaluate the gene admixture on the current genetic landscape in Gansu Corridor (GC) in China, the upper part of the ancient Silk Road which connects the Eastern and Central Asia, we examined mitochondrial DNA (mtDNA) polymorphisms of five ethnic populations in this study. Using PCR-RFLP and sequencing, we analyzed mtDNA haplotypes in 242 unrelated samples in three ethnic populations from the GC region and two ethnic populations from the adjacent Xinjiang Uygur Autonomous Region of China. We analyzed the data in comparison with the previously reported data from Eastern, Central and Western Asia and Europe. We found that both European-specific haplogroups and Eastern Asian-specific haplogroups exist in the Gansu Corridor populations, while a modest matrilineal gene flow from Europeans to this region was revealed. The Gansu Corridor populations are genetically located between Eastern Asians and Central Asians, both of who contributed significantly to the maternal lineages of the GC populations. This study made the landscape of the gene flow and admixture along the Silk Road from Europe, through Central Asia, to the upper part of the Silk Road more complete.
authors.affiliation: Key Laboratory of Bioresources Conservation and Utilization & Human Genetics Center, Yunnan University, Kunming 650091, China.
authors.forename: LiuQi
authors.initials: L
authors.lastname: Yang
authors.forename: SiJie
authors.initials: S
authors.lastname: Tan
authors.forename: HaiJing
authors.initials: H
authors.lastname: Yu
authors.forename: BingRong
authors.initials: B
authors.lastname: Zheng
authors.forename: EnFa
authors.initials: E
authors.lastname: Qiao
authors.forename: YongLi
authors.initials: Y
authors.lastname: Dong
authors.forename: RuiGuang
authors.initials: R
authors.lastname: Zan
authors.forename: ChunJie
authors.initials: C
authors.lastname: Xiao
mesh_terms: D001483:Base Sequence; D002681:China; D017931:DNA Primers; D004272:DNA, Mitochondrial / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D017931:DNA Primers; D004272:DNA, Mitochondrial