The cancer secretome: a reservoir of biomarkers.
Biomarkers are pivotal for cancer detection, diagnosis, prognosis and therapeutic monitoring. However, currently available cancer biomarkers have the disadvantage of lacking specificity and/or sensitivity. Developing effective cancer biomarkers becomes a pressing and permanent need. The cancer secretome, the totality of proteins released by cancer cells or tissues, provides useful tools for the discovery of novel biomarkers. The focus of this article is to review the recent advances in cancer secretome analysis. We aim to elaborate the approaches currently employed for cancer secretome studies, as well as its applications in the identification of biomarkers and the clarification of carcinogenesis mechanisms. Challenges encountered in this newly emerging field, including sample preparation, in vivo secretome analysis and biomarker validation, are also discussed. Further improvements on strategies and technologies will continue to drive forward cancer secretome research and enable development of a wealth of clinically valuable cancer biomarkers.
Xue
Hua
H
Department of Pathology, School of Medicine, Zhejiang University, PR China. snowhh@163.com
Lu
Bingjian
B
Lai
Maode
M
D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D016678:Genome; D006801:Humans; D009369:Neoplasms / Q000378:metabolism*; D040901:Proteomics
D014408:Biomarkers, Tumor
Mol Cell Proteomics. 2003 May;2(5):299-314
12766231
Proteomics. 2006 Aug;6(15):4381-9
16819731
Expert Rev Proteomics. 2004 Dec;1(4):401-9
15966837
Brief Funct Genomic Proteomic. 2004 Nov;3(3):280-6
15642190
Proteomics. 2005 Jan;5(1):307-17
15619298
Proteomics. 2008 Jan;8(2):316-32
18203259
J Am Soc Mass Spectrom. 2005 Aug;16(8):1207-20
15979338
Anal Chem. 2003 Oct 1;75(19):5054-61
14708778
Proteomics. 2005 Jul;5(10):2587-601
15912508
Proteomics. 2007 Jun;7(11):1757-70
17464941
Lung Cancer. 2006 Oct;54(1):87-94
16876904
Cancer Res. 2006 Feb 1;66(3):1376-83
16452192
Proteomics. 2005 Aug;5(13):3304-13
16052628
Exp Biol Med (Maywood). 2008 Jun;233(6):708-20
18408141
Mol Cell Proteomics. 2004 Apr;3(4):327-44
14754989
Proteomics. 2006 Dec;6(23):6326-53
17083142
Clin Chem. 2008 Mar;54(3):574-81
18202161
Pathol Res Pract. 2004;200(2):83-94
15237917
Cancer Lett. 2002 May 8;179(1):1-14
11880176
Clin Cancer Res. 2008 May 1;14(9):2579-87
18451219
Cancer Res. 2004 Jan 1;64(1):347-55
14729644
Minerva Urol Nefrol. 2008 Mar;60(1):51-60
18427435
Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13537-42
14573703
Biochemistry (Mosc). 2006 Oct;71(10):1060-72
17125453
J Physiol. 2005 Feb 15;563(Pt 1):23-60
15611012
J Proteome Res. 2008 Sep;7(9):3765-75
18646789
J Proteome Res. 2006 Oct;5(10):2861-4
17022658
J Cancer Res Clin Oncol. 2008 Jul;134(7):769-76
18202856
J Proteome Res. 2007 Mar;6(3):1083-92
17284061
Future Oncol. 2005 Feb;1(1):37-50
16555974
Electrophoresis. 1996 Jul;17(7):1265-72
8855415
J Proteome Res. 2004 May-Jun;3(3):469-77
15253428
Proteomics. 2005 Aug;5(13):3292-303
16052620
Microbiol Mol Biol Rev. 2000 Sep;64(3):515-47
10974125
J Proteome Res. 2005 Sep-Oct;4(5):1722-31
16212426
J Proteome Res. 2006 Apr;5(4):899-906
16602697
Mol Cell Proteomics. 2005 Oct;4(10):1480-6
15970581
Proteomics. 2004 Apr;4(4):1175-86
15048997
J Proteome Res. 2002 Jan-Feb;1(1):47-54
12643526
J Natl Cancer Inst. 2004 Sep 15;96(18):1356-7
15367567
Mol Cell Proteomics. 2006 Apr;5(4):573-88
16332733
Nature. 2008 Apr 3;452(7187):571-9
18385731
J Proteome Res. 2007 Mar;6(3):967-75
17330939
Trends Pharmacol Sci. 2006 May;27(5):251-9
16600386
Cancer Lett. 2006 Sep 8;241(1):49-58
16298039
J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Aug;855(1):14-20
17161666
J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Dec 25;813(1-2):1-26
15556511
Mol Cell Proteomics. 2005 Oct;4(10):1487-502
15979981
Mol Cell Proteomics. 2007 Nov;6(11):1997-2011
17656355
Lung Cancer. 2006 Oct;54(1):95-102
16890323
Proteomics. 2006 Jul;6(13):3739-53
16739131
Expert Rev Anticancer Ther. 2007 Aug;7(8):1105-15
18028019
Scand J Gastroenterol. 2004 Apr;39(4):380-4
15125471
Nature. 2003 Oct 30;425(6961):905
14586448
Proteomics. 2006 Nov;6(22):6107-16
17051643
Proteomics. 2005 Aug;5(13):3226-45
16104056
J Proteome Res. 2007 Aug;6(8):2993-3002
17608509
Mol Cell Proteomics. 2004 Dec;3(12):1154-69
15385600
Electrophoresis. 2005 Jul;26(14):2779-85
15966010
Oncogene. 2006 Dec 7;25(58):7650-61
17043663
Genome Res. 2001 Sep;11(9):1484-502
11544192
Arch Otolaryngol Head Neck Surg. 2007 Sep;133(9):910-8
17875858
Mol Cell Biochem. 2007 Apr;298(1-2):83-92
17109077
Nat Biotechnol. 1999 Oct;17(10):994-9
10504701
Breast Cancer Res Treat. 2003 Jul;80(1):87-97
12889602
Curr Probl Cancer. 2002 Jul-Aug;26(4):176-275
12399802
Nat Rev Cancer. 2003 Apr;3(4):243-52
12671663
Proteomics. 2003 Oct;3(10):1980-7
14625860
Expert Rev Proteomics. 2007 Feb;4(1):51-65
17288515
Cancer Immunol Immunother. 2009 Feb;58(2):247-58
18618111
Anticancer Res. 2007 May-Jun;27(3A):1247-55
17593616
Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3410-5
12624183
Eur J Cancer. 2001 Dec;37(18):2405-12
11720835
Anal Bioanal Chem. 2005 Jun;382(3):669-78
15900442
Clin Chem. 2007 Mar;53(3):429-37
17259234
J Proteome Res. 2008 Aug;7(8):3329-38
18578523
Technol Cancer Res Treat. 2008 Jun;7(3):155-60
18473487
J Urol. 1999 Dec;162(6):1930-3
10569540
Mol Cell Proteomics. 2006 Jan;5(1):157-71
16215274
J Proteome Res. 2008 Aug;7(8):3525-34
18630974
J Proteome Res. 2007 Jul;6(7):2802-11
17539671
Nat Rev Cancer. 2005 Nov;5(11):845-56
16239904
J Proteome Res. 2005 Jul-Aug;4(4):1442-50
16083298
Biotechniques. 2002 Apr;32(4):898, 900, 902 passim
11962611
Proteomics. 2005 Jul;5(10):2656-64
15924293
Best Pract Res Clin Obstet Gynaecol. 2002 Aug;16(4):469-82
12413929
J Proteomics. 2008 Apr 30;71(1):19-33
18541471
Proteomics. 2005 Aug;5(12):3173-82
16035111
Med Oncol. 2008;25(4):380-6
18300004
J Eval Clin Pract. 2008 Apr;14(2):275-80
18284517
Proteomics. 2004 May;4(5):1324-34
15188399
Brief Funct Genomic Proteomic. 2004 Nov;3(3):220-39
15642186
Proteomics. 2007 Dec;7(24):4589-600
18022937
FASEB J. 2005 Jul;19(9):1125-7
15985535
Ai Zheng. 2006 Nov;25(11):1361-7
17094902