Dexamphetamine normalises electrophysiological activity in attention deficit-hyperactivity disorder during the Stroop task.
A case study was conducted to investigate whether dexamphetamine enhances interference control in an adult with attention deficit/hyperactivity disorder. Continuous electroencephalography was recorded both on and off dexamphetamine during performance on a Stroop task. An age-, gender- and IQ-matched control also completed the same task. Event related potentials for the control participant revealed a positive potential to incongruent stimuli between 270 and 440 ms, whereas for the participant with attention deficit/hyperactivity disorder off medication, the reverse polarity was observed in a later time window. Following administration of dexamphetamine, however, the event-related potentials for the incongruent condition closely resembled those in the control, suggesting that dexamphetamine successfully normalises electroencephalographic activity.
Horrobin
S L
SL
Department of Psychology, Research Centre for Cognitive Neuroscience, University of Auckland, Auckland, New Zealand.
McNair
N A
NA
Kirk
I J
IJ
Waldie
K E
KE
D000328:Adult; D001288:Attention / Q000187:drug effects*; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000503:physiopathology; D016022:Case-Control Studies; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003220:Conflict, Psychological; D003265:Contingent Negative Variation / Q000187:drug effects*; D003913:Dextroamphetamine / Q000494:pharmacology*; D004192:Discrimination, Psychological / Q000187:drug effects; D004569:Electroencephalography / Q000187:drug effects; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D016555:Matched-Pair Analysis; D010364:Pattern Recognition, Visual / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D012016:Reference Values
D000697:Central Nervous System Stimulants; D003913:Dextroamphetamine