title: Histological results of sclerotherapy, phototherapy, and pulsed 980-nm laser irradiation of the dorsal rabbit ear vein.
abstract: OBJECTIVE
  To compare the histological changes occurring after three different treatment modalities for telangiectasias.
  
  
  METHODS
  Thirty 16-week-old New Zealand white rabbits weighing 2.4-3.1 kg were enrolled in the study. The rabbits were divided into three groups. The group 1 received sclerotherapy, he group 2 received phototherapy, and group 3 received high-power diode laser treatments. All animals were treated on the right dorsal marginal ear vein. Biopsies were taken on days 1, 2, 7, and 30 post-treatment, and histopathogical evaluation was performed.
  
  
  RESULTS
  Clinical and histological thrombosis occurred between days 1 and 7 in all groups. Superficial necrosis, neutrophil infiltration, and recanalization were mostly seen in group 3, whereas thrombosis was prominent in groups 1 and 2.
  
  
  CONCLUSIONS
  All of the methods tested appear to have similar mechanisms of action, but had differing clinical and histological results. Phototherapy and laser treatment are non-invasive and do not require an exact, pinpoint technique, in contrast to sclerotherapy. However, sclerotherapy and phototherapy showed better results, especially with regard to recanalization.
authors.affiliation: Department of Cardiovascular Surgery, Bursa Yüksek I'htisas Education and Research Hospital, Bursa, Turkey. ahvural@gmail.com
authors.forename: A Hakan
authors.initials: AH
authors.lastname: Vural
authors.forename: Cevdet
authors.initials: C
authors.lastname: Kocogullari
authors.forename: Nurcan
authors.initials: N
authors.lastname: Ozyazicioğlu
authors.forename: Tuğrul
authors.initials: T
authors.lastname: Göncü
authors.forename: Ayhan
authors.initials: A
authors.lastname: Ozcan
authors.forename: Serhat
authors.initials: S
authors.lastname: Yalçinkaya
authors.forename: Ahmet
authors.initials: A
authors.lastname: Bayer
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ozyazicioğlu
mesh_terms: D000818:Animals; D004431:Ear, External / Q000098:blood supply* / Q000187:drug effects / Q000528:radiation effects; D053685:Laser Therapy; D010789:Phototherapy; D011817:Rabbits; D015911:Sclerotherapy; D013684:Telangiectasis / Q000473:pathology* / Q000628:therapy*; D014680:Veins / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects