title: Psychological stress evaluation of patients with bronchial asthma based on the chromogranin a level in saliva.
abstract: To evaluate the involvement of stress in asthmatics we measured the concentration of chromogranin A (CgA) in saliva as an indicator of psychological stress and investigated its correlation with peak expiratory flow (PEF), a visual analog scale (VAS) score of symptoms, and the score of the Short-form 36 health survey questionnaire (SF-36) in 62 adult asthmatics. CgA had a significant correlation with role physical (RP) (r = -0.298, p < 0.05), role emotional (RE) (r = -0.294, p < 0.05) and the physical component summary (PCS) (r = -0.310, p < 0.05) of SF-36, and VAS score (r = -0.435, p < 0.01). We concluded that the concentration of CgA reflects the stress in asthmatics caused by work or daily life limitations.
authors.affiliation: Third Department of Internal Medicine, Iwate Medical University School of Medicine, Uchimaru, Morioka, Japan. hoshinok@iwate-med.ac.jp
authors.forename: Ken
authors.initials: K
authors.lastname: Hoshino
authors.forename: Jun
authors.initials: J
authors.lastname: Suzuki
authors.forename: Kohei
authors.initials: K
authors.lastname: Yamauchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Inoue
mesh_terms: D000328:Adult; D000368:Aged; D001249:Asthma / Q000523:psychology*; D053379:Chromogranin A / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010366:Peak Expiratory Flow Rate; D012463:Saliva / Q000737:chemistry*; D013315:Stress, Psychological / Q000175:diagnosis / Q000503:physiopathology; D011795:Surveys and Questionnaires
chemical_list: D053379:Chromogranin A