Effect of phenobarbital on hepatic injury induced by chronic carbon tetrachloride treatment.
Rats were given 1 ml CCl4 per kg body weight subcutaneously 2 times a week, for 16 weeks. The effects of simultaneous phenobarbital (PB) treatment (0.05% in drinking water) on the hepatotoxicity of CCl4 was studied during 16 weeks of treatment. The retardation of growth, the increase in liver weight and mortality were greater in animals receiving both PB and CCl4 than those given CCl4 alone. Cirrhosis was apparent only in animals treated by PB + CCl4. The potentiating effect of PB on CCl4 hepatotoxicity was also seen in hexobarbital sleeping time, the rate of hexobarbital metabolism, and the cytochrome P-450 content in liver microsomes. The inducing effect of PB alone decreased with time both in vivo and in vitro, which suggests an adaptation or some kind of exhaustion of liver to the effects of PB.
Vorne
M
M
Department of Pharmacology, University of Oulu, Finland.
Arvela
P
P
Alavaikko
M
M
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury; D004357:Drug Synergism; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D006591:Hexobarbital / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000293:injuries / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology*; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D018691:Excitatory Amino Acid Antagonists; D006591:Hexobarbital; D002251:Carbon Tetrachloride; D010634:Phenobarbital