title: Offline LC-GC x GC in combination with rapid-scanning quadrupole mass spectrometry.
abstract: The present research is focused on the offline combination of normal-phase LC to double-oven GC x GC-quadrupole MS. Initially, a diesel sample was subjected to automated LC x GC in order to define the elution windows of four fractions, viz., saturated hydrocarbons, monocyclic aromatics, dicyclic aromatics, tri- + tetracyclic aromatics; each fraction was collected exploiting the LC system in a further analysis and subjected to large-volume-injection-GC x GC analysis using an apolar-polar column combination. The GC x GC operational conditions were tuned in relation to the specific separation requirements of each heart-cut. The main benefits of what can be defined as offline LC-GC x GC were: (i) the high first-dimension LC selectivity; (ii) the injection of high sample amounts in the GC x GC system, enabling the detection and quantification of a series of low-amount diesel constituents; (iii) improved GC x GC operational conditions for each heart-cut with respect to direct GC x GC.
authors.affiliation: Dipartimento Farmaco-chimico, Facoltà di Farmacia, Università di Messina, Messina, Italy.
authors.forename: Danilo
authors.initials: D
authors.lastname: Sciarrone
authors.forename: Peter Quinto
authors.initials: PQ
authors.lastname: Tranchida
authors.forename: Rosaria
authors.initials: R
authors.lastname: Costa
authors.forename: Paola
authors.initials: P
authors.lastname: Donato
authors.forename: Carla
authors.initials: C
authors.lastname: Ragonese
authors.forename: Paola
authors.initials: P
authors.lastname: Dugo
authors.forename: Giovanni
authors.initials: G
authors.lastname: Dugo
authors.forename: Luigi
authors.initials: L
authors.lastname: Mondello
mesh_terms: D002849:Chromatography, Gas / Q000295:instrumentation / Q000379:methods*; D002853:Chromatography, Liquid / Q000295:instrumentation / Q000379:methods*; D005742:Gasoline / Q000032:analysis; D013058:Mass Spectrometry / Q000295:instrumentation / Q000379:methods*
chemical_list: D005742:Gasoline