title: Comparison of lipid lowering effect of sibutramine in patients treated or not treated with statins--3 month follow-up.
abstract: Older sibutramine studies showed beneficial effects on lipid profile compared to placebo. However, nowadays many obese patients are treated with lipid lowering drugs before the start of sibutramine therapy and their effects in these patients have not been investigated. Therefore we started a long-term follow up of patients on sibutramine with or without previous and continuing statins. Here we present results of the first 3 months follow up of 11 patients on sibutramine 10 mg +statin group, and that of 13 patients on sibutramine 10 mg alone. Sibutramine led to the weight loss from 101.6 to 96.9 kg and in BMI from 36.35 to 34.66 kg/m2. Lipid profile changed thus: total cholesterol 4.97...5.01mmol/l (p = 0.7), LDL cholesterol 2.83...2.82 mmol/l mmol/l (p = 0.9), HDL cholesterol 1.13...1.27 mmol/l (p = 0.003), triglycerides 1.98...1.91 mmol/l (p = 0.01). Comparison between the 2 groups did not show any significant differences in lipid levels, patients react to sibutramine in the same way regardless to the concomitant statin therapy. We can therefore preliminarily conclude that sibutramine therapy has significant positive effect on the lipid profile even in patients who were started on statins prior to initiation of sibutramine treatment.
authors.affiliation: Charles University in Prague, First Faculty of Medicine and General Teaching Hospital, Third Medical Department, Prague, Czech Republic. stepan.svacina@lf1.cuni.cz
authors.forename: S
authors.initials: S
authors.lastname: Svacina
authors.forename: K
authors.initials: K
authors.lastname: Owen
authors.forename: J
authors.initials: J
authors.lastname: Hendl
authors.forename: M
authors.initials: M
authors.lastname: Matoulek
authors.forename: T
authors.initials: T
authors.lastname: Brychta
mesh_terms: D001067:Appetite Depressants / Q000627:therapeutic use*; D003503:Cyclobutanes / Q000627:therapeutic use*; D050171:Dyslipidemias / Q000150:complications / Q000188:drug therapy; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood*; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications / Q000188:drug therapy*
chemical_list: D001067:Appetite Depressants; D003503:Cyclobutanes; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008055:Lipids; C058254:sibutramine