Nanocomposites of 2-arylpropionic acid drugs based on Mg-Al layered double hydroxide for dissolution enhancement.
Naproxen (NP) and flurpibrofen (FB) as non-steroidal anti-inflammatory drugs (NSAIDs) of 2-arylpropionic acid derivatives have been used as host organic drugs to be intercalated into layered double hydroxide (LDH) applying reconstruction and co-precipitation techniques. The obtained NP-LDH and FB-LDH nanocomposites were characterized by X-ray powder diffraction, infrared and thermogravimetric analyses. From drug loading, thermal analysis and X-ray measurements we can decide that coprecipitaion technique is better than reconstruction technique to obtain intercalated monophase nanocomposites. In acidic medium LDH dissolved and the intercalated drug starts to release in a molecular form which is suitable for adsorption. The drug solubility has been investigated before and after intercalation. It has been found that LDH improves the drug solubility and its dissolution rate.
Berber
Mohamed R
MR
Institute of Technology and Science, The University of Tokushima, Japan. mrberber@sy34.chem.tokushima-u.ac.jp
Minagawa
Keiji
K
Katoh
Masahiro
M
Mori
Takeshi
T
Tanaka
Masami
M
D000536:Aluminum Hydroxide / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004055:Differential Thermal Analysis; D005079:Excipients; D005480:Flurbiprofen / Q000008:administration & dosage / Q000737:chemistry*; D007770:L-Lactate Dehydrogenase / Q000737:chemistry; D008276:Magnesium Hydroxide / Q000737:chemistry*; D053758:Nanoparticles; D009288:Naproxen / Q000008:administration & dosage / Q000737:chemistry*; D012995:Solubility; D013055:Spectrophotometry, Infrared; D014961:X-Ray Diffraction
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005079:Excipients; D009288:Naproxen; D005480:Flurbiprofen; D000536:Aluminum Hydroxide; D007770:L-Lactate Dehydrogenase; D008276:Magnesium Hydroxide