title: Subjective responses and cardiovascular effects of self-administered cocaine in cocaine-abusing men and women.
abstract: This study aimed to examine sex differences in cocaine self-administration and cocaine-induced subjective and cardiovascular measures. The research was based on secondary analysis of data collected in our human laboratory in which subjects self-administered cocaine infusions (8, 16 and 32 mg/70 kg) over a 2-hour period under a fixed ratio 1, 5 minute time out schedule in three test sessions. Subjects were 10 women and 21 men with a history of either cocaine abuse or dependence who were not currently seeking treatment. Women and men self-administered similar amounts of cocaine. None of the subjective effects measures showed a significant main effect of sex during the cocaine self-administration session. Significant interactions were observed for subjective ratings of 'high' (sex x time) and 'stimulated' (sex x time x dose), with women reporting lower ratings over time/doses than men. Relative to men, cocaine produced dose- and time-dependent increases in feelings of hunger (i.e., reduced appetite suppression) in women. Systolic and diastolic blood pressures showed different patterns of change in men and women, with women showing less robust cocaine-induced increases than men. Taken together, these findings suggest that women and men may differ in their subjective and cardiovascular responses to self-administered cocaine. Further research that prospectively controls for hormonal influences upon these measures is needed.
authors.affiliation: Department of Psychiatry and Neurobehavioral Sciences, University of Virginia Health Sciences, 1670 Discovery Drive, Charlottesville, VA 22911, USA. wlynch@virginia.edu
authors.forename: Wendy J
authors.initials: WJ
authors.lastname: Lynch
authors.forename: Rasmon
authors.initials: R
authors.lastname: Kalayasiri
authors.forename: Atapol
authors.initials: A
authors.lastname: Sughondhabirom
authors.forename: Brian
authors.initials: B
authors.lastname: Pittman
authors.forename: Vladimir
authors.initials: V
authors.lastname: Coric
authors.forename: Peter T
authors.initials: PT
authors.lastname: Morgan
authors.forename: Robert T
authors.initials: RT
authors.lastname: Malison
mesh_terms: D000328:Adult; D001835:Body Weight; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000453:epidemiology*; D019970:Cocaine-Related Disorders / Q000191:economics / Q000453:epidemiology* / Q000534:rehabilitation; D004562:Electrocardiography; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D012646:Self Administration; D017678:Sex Distribution; D055815:Young Adult
references.citation: J Lab Clin Med. 1993 Aug;122(2):157-63
references.pmid: 8340700
references.citation: Psychopharmacology (Berl). 1999 May;144(1):77-82
references.pmid: 10379627
references.citation: Biol Psychiatry. 1996 Jan 15;39(2):147-8
references.pmid: 8717615
references.citation: Neuropsychopharmacology. 2004 Jan;29(1):81-5
references.pmid: 12955098
references.citation: Psychopharmacology (Berl). 1996 Jun;125(4):346-54
references.pmid: 8826539
references.citation: Pharmacol Biochem Behav. 1997 Jul;57(3):571-99
references.pmid: 9218281
references.citation: Trends Pharmacol Sci. 2004 May;25(5):273-9
references.pmid: 15120494
references.citation: Psychopharmacology (Berl). 2002 Nov;164(2):121-37
references.pmid: 12404074
references.citation: Psychopharmacology (Berl). 2006 Apr;185(3):306-14
references.pmid: 16521032
references.citation: Pharmacol Biochem Behav. 2006 Feb;83(2):249-56
references.pmid: 16549106
references.citation: Ann N Y Acad Sci. 2001 Jun;937:172-87
references.pmid: 11458536
references.citation: Psychopharmacology (Berl). 1989;98(3):408-11
references.pmid: 2501818
references.citation: Psychopharmacology (Berl). 2005 Jul;180(3):436-46
references.pmid: 15726333
references.citation: Pharmacol Biochem Behav. 2007 Jan;86(1):117-24
references.pmid: 17257663
references.citation: Am J Drug Alcohol Abuse. 2000 Nov;26(4):643-57
references.pmid: 11097197
references.citation: Exp Clin Psychopharmacol. 1999 Aug;7(3):274-83
references.pmid: 10472516
references.citation: Neuropsychopharmacology. 1999 Sep;21(3):445-54
references.pmid: 10457542
references.citation: Drug Alcohol Depend. 2006 Sep 1;84(1):1-13
references.pmid: 16413143