Comparison of perceived itch induced by skin prick-tests with histamine and codeine.
The role of personal factors makes it difficult to correlate subjective data, such as those obtained with the use of a visual analogue scale, and objective data, such as a quantity of injected histamine. In this study, prick tests with histamine and codeine on the forearms allowed a coherent variation in itch scores to be obtained over time, with highly significant differences from controls and with a peak at 4 minutes. These tests are therefore valuable for screening anti-pruritic agents. A significant difference between initial scores and scores for new prick tests after 7 days suggest that tachyphylaxis persists.
Theunis
Jennifer
J
Pierre Fabre Research Institute, Toulouse, France.
Black
David
D
Degouy
Arnaud
A
Schmitt
Anne-Marie
AM
Misery
Laurent
L
D000293:Adolescent; D000328:Adult; D000701:Analgesics, Opioid; D003061:Codeine; D004311:Double-Blind Method; D006632:Histamine; D017442:Histamine Agonists; D006801:Humans; D008297:Male; D011537:Pruritus / Q000139:chemically induced*; D012720:Severity of Illness Index; D012882:Skin Tests; D055815:Young Adult
D000701:Analgesics, Opioid; D017442:Histamine Agonists; D006632:Histamine; D003061:Codeine