title: Dental caries: a dynamic disease process.
abstract: Abstract Dental caries is a transmissible bacterial disease process caused by acids from bacterial metabolism diffusing into enamel and dentine and dissolving the mineral. The bacteria responsible produce organic acids as a by-product of their metabolism of fermentable carbohydrates. The caries process is a continuum resulting from many cycles of demineralization and remineralization. Demineralization begins at the atomic level at the crystal surface inside the enamel or dentine and can continue unless halted with the end-point being cavitation. There are many possibilities to intervene in this continuing process to arrest or reverse the progress of the lesion. Remineralization is the natural repair process for non-cavitated lesions, and relies on calcium and phosphate ions assisted by fluoride to rebuild a new surface on existing crystal remnants in subsurface lesions remaining after demineralization. These remineralized crystals are acid resistant, being much less soluble than the original mineral.
authors.affiliation: Department of Preventive and Restorative Dental Sciences, University of California, San Francisco, USA. jdbf@ucsf.edu
authors.forename: J D B
authors.initials: JD
authors.lastname: Featherstone
mesh_terms: D002130:Calcium Phosphates / Q000378:metabolism; D002327:Cariostatic Agents / Q000378:metabolism / Q000627:therapeutic use*; D003460:Crystallization; D003731:Dental Caries / Q000188:drug therapy / Q000378:metabolism*; D003743:Dental Enamel / Q000378:metabolism; D003747:Dental Enamel Solubility; D003773:Dental Plaque / Q000382:microbiology; D003808:Dentin Solubility; D018450:Disease Progression; D005459:Fluorides / Q000378:metabolism / Q000627:therapeutic use; D006801:Humans; D007778:Lactobacillus / Q000378:metabolism; D013295:Streptococcus mutans / Q000378:metabolism; D014089:Tooth Remineralization
chemical_list: D002130:Calcium Phosphates; D002327:Cariostatic Agents; C020243:calcium phosphate; D005459:Fluorides