title: Differential requirements of a mitotic acetyltransferase in somatic and germ line cells.
abstract: During mitosis different types of cells can have differential requirements for chromosome segregation. We isolated two new alleles of the separation anxiety gene (san). san was previously described in both Drosophila and in humans to be required for centromeric sister chromatid cohesion (Hou et al., 2007; Williams et al., 2003). Our work confirms and expands the observation that san is required in vivo for normal mitosis of different types of somatic cells. In addition, we suggest that san is also important for the correct resolution of chromosomes, implying a more general function of this acetyltransferase. Surprisingly, during oogenesis we cannot detect mitotic defects in germ line cells mutant for san. We hypothesize the female germ line stem cells have differential requirements for mitotic sister chromatid cohesion.
authors.affiliation: Instituto Gulbenkian de Ciência, Rua da Quinta Grande, n 6, 2781-901 Oeiras, Portugal.
authors.forename: Ana
authors.initials: A
authors.lastname: Pimenta-Marques
authors.forename: Rui
authors.initials: R
authors.lastname: Tostões
authors.forename: Thomas
authors.initials: T
authors.lastname: Marty
authors.forename: Vítor
authors.initials: V
authors.lastname: Barbosa
authors.forename: Ruth
authors.initials: R
authors.lastname: Lehmann
authors.forename: Rui Gonçalo
authors.initials: RG
authors.lastname: Martinho
mesh_terms: D000123:Acetyltransferases / Q000378:metabolism*; D000483:Alleles; D000818:Animals; D001756:Blastoderm / Q000166:cytology / Q000201:enzymology; D020090:Chromosome Segregation; D002875:Chromosomes / Q000201:enzymology; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000166:cytology* / Q000196:embryology / Q000201:enzymology* / Q000235:genetics; D017344:Genes, Insect; D005854:Germ Cells / Q000166:cytology* / Q000201:enzymology*; D007814:Larva / Q000166:cytology / Q000201:enzymology; D008938:Mitosis; D009474:Neurons / Q000166:cytology / Q000201:enzymology; D009866:Oogenesis; D012854:Sister Chromatid Exchange; D015053:Zygote / Q000166:cytology / Q000201:enzymology
chemical_list: D029721:Drosophila Proteins; D000123:Acetyltransferases; C533244:San protein, Drosophila
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