title: Day-night variations of serum interleukin-6 in patients with severe obstructive sleep apnea syndrome before and after continuous positive airway pressure (CPAP).
abstract: Obstructive sleep apnea syndrome (OSAS) causes intermittent hypoxia and increases in sympathetic activity and contributes to cardiovascular disorders. Interleukin-6 (IL-6) is one of the important proinflammatory cytokines. We examined the levels of serum IL-6 concentrations in nine patients with severe OSAS at four different clock times during the 24 h before and after three months of continuous positive airway pressure (CPAP) therapy. Serum IL-6 levels were significantly reduced after CPAP therapy by 46% (6.2+/-1.0 vs. 3.3+/-0.4 pg/ml, p<0.005). No significant 24 h variation of serum IL-6 in severe OSAS patients was found before CPAP; however, a significant 24 h variation of serum IL-6 was found after CPAP. Intermittent hypoxia during sleep may contribute to systemic inflammation and result in an elevation of serum IL-6 in severe OSAS patients.
authors.affiliation: Division of Medical Oncology and Molecular Respirology, Faculty of Medicine, Tottori University, Yonago, Japan. burioka@grape.med.tottori-u.ac.jp
authors.forename: Naoto
authors.initials: N
authors.lastname: Burioka
authors.forename: Masanori
authors.initials: M
authors.lastname: Miyata
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Fukuoka
authors.forename: Masahiro
authors.initials: M
authors.lastname: Endo
authors.forename: Eiji
authors.initials: E
authors.lastname: Shimizu
mesh_terms: D002940:Circadian Rhythm / Q000502:physiology*; D045422:Continuous Positive Airway Pressure; D003624:Darkness; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008027:Light; D008875:Middle Aged; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000473:pathology / Q000628:therapy*; D013997:Time Factors
chemical_list: D015850:Interleukin-6