title: Thymic stromal lymphopoietin (TSLP) as a bridge between infection and atopy.
abstract: The rising worldwide prevalence of asthma has intensified interest in the natural history of asthma. An improved understanding of the genetic, environmental, and developmental factors contributing to the inception and exacerbation of asthma will be crucial to efforts to devise effective preventive and therapeutic interventions. There is increasing evidence that the complex interplay of early life respiratory viral infections and allergic sensitization is important in the development of asthma. Major causes of asthma exacerbations are respiratory viral infections and aeroallergen exposure, which may have interactive co-morbid effects. This review describes the potential role of thymic stromal lymphopoietin (TSLP) as a connection between the innate immune response to respiratory viral infections and the type-2 adaptive immune response in the development and exacerbation of asthma.
authors.affiliation: Waisman Center for Developmental Disabilities, the Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. sesnault@wisc.edu
authors.forename: Stéphane
authors.initials: S
authors.lastname: Esnault
authors.forename: Louis A
authors.initials: LA
authors.lastname: Rosenthal
authors.forename: Deng-Shun
authors.initials: DS
authors.lastname: Wang
authors.forename: James S
authors.initials: JS
authors.lastname: Malter
references.citation: J Allergy Clin Immunol. 2005 May;115(5):953-9
references.pmid: 15867851
references.citation: Am J Respir Crit Care Med. 2005 Aug 15;172(4):433-9
references.pmid: 15894599
references.citation: Thorax. 1993 Jan;48(1):26-32
references.pmid: 8434349
references.citation: Blood. 2002 Nov 1;100(9):3269-78
references.pmid: 12384427
references.citation: J Exp Med. 2007 Feb 19;204(2):253-8
references.pmid: 17242164
references.citation: Nat Immunol. 2005 May;6(5):507-14
references.pmid: 15821737
references.citation: Am J Respir Crit Care Med. 2005 Jan 15;171(2):137-41
references.pmid: 15516534
references.citation: J Allergy Clin Immunol. 2005 Aug;116(2):267-73
references.pmid: 16083778
references.citation: Clin Exp Allergy. 2005 May;35(5):672-8
references.pmid: 15898992
references.citation: J Allergy Clin Immunol. 2005 Apr;115(4):668-74; quiz 675
references.pmid: 15805982
references.citation: Nature. 1999 Nov 25;402(6760 Suppl):B24-30
references.pmid: 10586892
references.citation: Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11736-41
references.pmid: 16880407
references.citation: Nat Rev Immunol. 2002 Feb;2(2):132-8
references.pmid: 11910895
references.citation: J Exp Med. 2005 Mar 21;201(6):937-47
references.pmid: 15781584
references.citation: Nat Immunol. 2002 Jul;3(7):673-80
references.pmid: 12055625
references.citation: J Immunol. 2007 Jun 1;178(11):6720-4
references.pmid: 17513717
references.citation: J Allergy Clin Immunol. 2007 May;119(5):1105-10
references.pmid: 17353039
references.citation: BMJ. 1995 May 13;310(6989):1225-9
references.pmid: 7767192
references.citation: J Immunol. 2007 Jul 15;179(2):1080-7
references.pmid: 17617600
references.citation: Am J Respir Crit Care Med. 1999 Jul;160(1):100-8
references.pmid: 10390386
references.citation: J Allergy Clin Immunol. 2004 Apr;113(4):697-702
references.pmid: 15100676
references.citation: J Immunol. 2001 Jul 1;167(1):336-43
references.pmid: 11418668
references.citation: Nat Med. 2006 Sep;12(9):1023-6
references.pmid: 16906156
references.citation: J Exp Med. 2000 Sep 4;192(5):671-80
references.pmid: 10974033
references.citation: Eur J Immunol. 1993 Jul;23(7):1445-9
references.pmid: 8100770
references.citation: J Allergy Clin Immunol. 2004 Nov;114(5):1023-6
references.pmid: 15536404
references.citation: J Allergy Clin Immunol. 2007 Apr;119(4):982-90
references.pmid: 17320941
references.citation: Am J Respir Cell Mol Biol. 1999 Jun;20(6):1220-8
references.pmid: 10340941
references.citation: J Exp Med. 1992 Aug 1;176(2):587-92
references.pmid: 1380064
references.citation: Cytogenet Cell Genet. 2001;93(1-2):23-5
references.pmid: 11474172
references.citation: Chest. 2006 Oct;130(4):1203-10
references.pmid: 17035457
references.citation: Pediatr Infect Dis J. 2005 Nov;24(11 Suppl):S170-6, discussion S174-5
references.pmid: 16378042
references.citation: Nat Immunol. 2005 Oct;6(10):1047-53
references.pmid: 16142237
references.citation: J Allergy Clin Immunol. 2005 Sep;116(3):571-7
references.pmid: 16159626
references.citation: Proc Am Thorac Soc. 2007 Jul;4(3):267-70
references.pmid: 17607011
references.citation: Clin Exp Immunol. 1996 Jan;103(1):111-8
references.pmid: 8565269
references.citation: Lancet. 1999 Aug 14;354(9178):541-5
references.pmid: 10470697
references.citation: J Exp Med. 2005 Sep 19;202(6):829-39
references.pmid: 16172260
references.citation: J Exp Med. 2005 Aug 15;202(4):541-9
references.pmid: 16103410
references.citation: Eur J Immunol. 1989 Aug;19(8):1419-24
references.pmid: 2789139
references.citation: Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):914-9
references.pmid: 17213320
references.citation: J Immunol. 1992 Apr 15;148(8):2390-4
references.pmid: 1560199
references.citation: Exp Hematol. 1994 Mar;22(3):321-8
references.pmid: 8112430
references.citation: J Immunol. 2002 Apr 1;168(7):3288-94
references.pmid: 11907084
references.citation: Immunology. 1997 Jul;91(3):361-8
references.pmid: 9301524
references.citation: N Engl J Med. 1992 Jan 30;326(5):298-304
references.pmid: 1530827