title: Macular structure and vision of patients with macular heterotopia secondary to retinopathy of prematurity.
abstract: OBJECTIVE
  To examine if vision in subjects with macular heterotopia (MH) secondary to retinopathy of prematurity (ROP) is related to anatomical macular structure.
  
  
  METHODS
  Six subjects with MH who were between 18 years and 65 years of age and three age-matched subjects with normal vision were recruited for the study. Vision and macular structure of the better eye of the subjects with MH and the dominant eye of age-matched subjects with normal vision were assessed. High contrast visual acuity and contrast sensitivity were measured using Early Treatment of Diabetic Retinopathy Study and Pelli-Robson charts, respectively. The Micro Perimeter (Nidek Technologies MP-1) was used to assess macular sensitivity and fixation stability. Using optical coherence tomography, macular thickness and relative retinal thickness at fixation were measured.
  
  
  RESULTS
  Subjects with MH had significantly reduced visual acuity and macular sensitivity compared with age-matched subjects with normal vision. In comparison with their age-matched counterparts, subjects with MH had significantly increased macular thickness and increased relative retinal thickness at fixation. A normal foveal architecture was absent in three subjects with MH (50%).
  
  
  CONCLUSIONS
  Patients with MH secondary to ROP have increased macular thickness and reduced vision.
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, IL 60612, USA.
authors.forename: Grace P
authors.initials: GP
authors.lastname: Soong
authors.forename: Michael
authors.initials: M
authors.lastname: Shapiro
authors.forename: William
authors.initials: W
authors.lastname: Seiple
authors.forename: Janet P
authors.initials: JP
authors.lastname: Szlyk
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002828:Choristoma / Q000150:complications* / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D005584:Fovea Centralis / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D008266:Macula Lutea / Q000473:pathology* / Q000503:physiopathology; D008875:Middle Aged; D012164:Retinal Diseases / Q000150:complications* / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D012178:Retinopathy of Prematurity / Q000150:complications*; D015354:Vision, Low / Q000209:etiology* / Q000503:physiopathology; D014792:Visual Acuity; D055815:Young Adult