A concise approach to the polycyclic scaffold of frondosin D.
In a study directed at developing a concise approach to the polycyclic core of frondosin D, a Stille-Heck sequence has been identified that gives direct access to the trimethylbicyclo[5.4.0]undecane ring system common to all frondosins.
Masters
Kye-Simeon
KS
Department of Medicinal Chemistry, Victorian College of Pharmacy, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia.
Flynn
Bernard L
BL
D000473:Alkanes / Q000737:chemistry; D001643:Bridged Bicyclo Compounds / Q000737:chemistry*; D003500:Cyclization; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry*
D000473:Alkanes; D001643:Bridged Bicyclo Compounds; D006576:Heterocyclic Compounds, 4 or More Rings; C534373:frondosin D; C534372:trimethylbicyclo(5.4.0)undecane; C022884:undecane