New conformationally restricted DNA mimics.
Two novel bicyclic nucleotide monomers have been developed for use as DNA mimics. Melting temperature studies showed that these modifications decrease binding affinity towards complementary DNA and RNA.
Højland
Torben
T
Nucleic Acid Center, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark. tho@ifk.sdu.dk
Babu
B Ravindra
BR
Wengel
Jesper
J
D004247:DNA / Q000737:chemistry*; D018716:Molecular Mimicry; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D013696:Temperature
D009841:Oligonucleotides; C477371:locked nucleic acid; D004247:DNA