Lead compounds for anti-inflammatory drugs isolated from the plants of the traditional oriental medicine in Korea.
Effects of compounds isolated from medicinal plants in Korea on prostaglandin E2 (PGE2) production in rat peritoneal macrophages were examined, and mechanism of action of the active constituents was analyzed. The active constituents were as follows; tectorigenin and tectoridin isolated from the rhizomes of Belamcanda chinensis, platycodin D isolated from the roots of Platycodon grandiflorum, imperatorin isolated from the roots of Angelica dahurica, and hyperin isolated from the roots of Acanthopanax chiisanensis. These compounds inhibit the induction of cyclooxygenase-2 (COX-2), thus inhibiting PGE2 production. The chemically synthesized chalcone derivative, 2'-hydroxy-4'-methoxychalcone, also inhibits PGE2 production by suppressing COX-2 induction. In contrast, taiwanin C isolated from the roots of Acanthopanax chiisanensis inhibited PGE2 production by direct inhibition of COX-1 and COX-2.
Hong
JangJa
J
Laboratory of Life Sciences, Faculty of Pharmacy, Yasuda Women's University, Hiroshima, Japan.
Shin
Kuk Hyun
KH
Lim
Soon Sung
SS
Kwak
Jong Hwan
JH
Zee
OkPyo
O
Ishihara
Kenji
K
Hirasawa
Noriyasu
N
Seyama
Toshio
T
Ohuchi
Kazuo
K
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology*; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D015232:Dinoprostone / Q000096:biosynthesis*; D004353:Drug Evaluation, Preclinical; D011564:Furocoumarins / Q000737:chemistry / Q000494:pharmacology; D007529:Isoflavones / Q000737:chemistry / Q000276:immunology / Q000378:metabolism / Q000494:pharmacology; D007723:Korea; D007783:Lactones / Q000737:chemistry / Q000494:pharmacology; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000378:metabolism; D008518:Medicine, East Asian Traditional; D008517:Phytotherapy; D011794:Quercetin / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D012503:Saponins / Q000737:chemistry / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D011564:Furocoumarins; D007529:Isoflavones; D007783:Lactones; D017705:Lignans; D012503:Saponins; D014315:Triterpenes; C467766:taiwanin C; C120039:tectorigenin; C021304:hyperoside; C120040:tectoridin; D011794:Quercetin; C108953:platycodin D; C031534:imperatorin; D015232:Dinoprostone