Follow-up of mild cognitive impairment and related disorders over four years in adults in their sixties: the PATH Through Life Study.
OBJECTIVE
The study aimed to estimate incidence rates of mild cognitive impairment and related disorders, and conversion to dementia.


METHODS
The data are drawn from the PATH Through Life Study. Baseline assessment in 2001-2002 included 2,551 participants 60-64 years old with 2,222 participating in a 4-year follow-up. Those screened positive with a cognitive assessment received clinical assessment for diagnoses of mild cognitive disorders (MCD) or dementia using established clinical criteria. Prevalence and incidence rates for the cohort were estimated with predictive regression models.


RESULTS
Annual incidence of dementia was 0.25%. Prevalence of mild cognitive impairment was 4.2%, age-associated memory impairment was 2.4%, age-associated cognitive decline was 7.6%, mild neurocognitive disorders occurred in 12.9% and other cognitive disorders in 7.3%. Prevalence of any diagnosis of any MCD (Any-MCD) was 29.5% and the annual incidence rate for Any-MCD was 5.7%. Agreement for specific diagnoses between waves 1 and 2 was fair to poor (0-47.0%), but agreement for Any-MCD over 4 years was 89.0%.


CONCLUSIONS
MCD diagnoses do not predict dementia at a 4-year follow-up in young-old adults. Prevalence rates for MCD vary greatly depending on the criteria and time of assessment.
Anstey
Kaarin J
KJ
Centre for Mental Health Research, Australian National University, Canberra, A.C.T., Australia. kaarin.anstey@anu.edu.au
Cherbuin
Nicolas
N
Christensen
Helen
H
Burns
Richard
R
Reglade-Meslin
Chantal
C
Salim
Agus
A
Kumar
Rajeev
R
Jorm
Anthony F
AF
Sachdev
Perminder
P
D003072:Cognition Disorders / Q000175:diagnosis* / Q000453:epidemiology*; D003704:Dementia / Q000175:diagnosis* / Q000453:epidemiology*; D042241:Early Diagnosis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D015995:Prevalence; D012720:Severity of Illness Index
Int Psychogeriatr. 2004 Jun;16(2):129-40
15318760
Int J Neurol. 1987-1988;21-22:73-82
2980693
Arch Neurol. 1999 Mar;56(3):303-8
10190820
Acta Neurol Scand. 2003 Aug;108(2):71-81
12859282
J Neurol Neurosurg Psychiatry. 2006 Feb;77(2):159-65
16103044
J Am Geriatr Soc. 2006 Apr;54(4):580-6
16686866
J Am Geriatr Soc. 1989 Aug;37(8):725-9
2754157
Q J Exp Psychol A. 2005 Jan;58(1):5-21
15881288
Ann Intern Med. 2008 Mar 18;148(6):427-34
18347351
Neurology. 2007 Jan 23;68(4):288-91
17242334
Neuropsychologia. 2007 Apr 9;45(8):1911-20
17240409
Neurology. 2002 Nov 26;59(10):1594-9
12451203
Neurology. 2001 Jan 9;56(1):37-42
11148233
J Gerontol. 1992 May;47(3):P154-8
1573197
Dement Geriatr Cogn Disord. 2006;22(5-6):465-70
17047325
Neurology. 1989 Sep;39(9):1159-65
2771064
Age Ageing. 1996 May;25(3):201-5
8670552
Neuropsychology. 2005 May;19(3):309-17
15910117
JAMA. 1999 Nov 10;282(18):1737-44
10568646
Arch Gerontol Geriatr. 2007;44 Suppl 1:233-41
17317458
Dement Geriatr Cogn Disord. 2006;21(1):44-50
16254430
Acta Neurol Scand Suppl. 2003;179:14-20
12603245
Neurobiol Aging. 2006 Jul;27(7):933-40
16023766
Clin Ther. 2006 Jul;28(7):991-1001
16990077
Arch Gen Psychiatry. 1983 Jul;40(7):812
6860082
Int Psychogeriatr. 2006 Sep;18(3):471-80
16466589
Alzheimer Dis Assoc Disord. 2006 Jul-Sep;20(3 Suppl 2):S52-7
16917196
Percept Mot Skills. 1971 Oct;33(2):575-81
5124116
Psychol Aging. 2004 Jun;19(2):243-59
15222818
Am J Psychiatry. 2005 Nov;162(11):2071-7
16263846
Psychol Med. 2005 Sep;35(9):1253-63
16168148
Neurology. 1999 Apr 22;52(7):1397-403
10227624
J Intern Med. 2004 Sep;256(3):195-204
15324363
Int Psychogeriatr. 2001 Sep;13(3):299-310
11768377
Int J Geriatr Psychiatry. 2002 Aug;17(8):704-9
12211118
Arch Neurol. 2001 Dec;58(12):1985-92
11735772
Neuroscience. 2006 Dec;143(3):793-803
17049178
Dement Geriatr Cogn Disord. 2005;19(2-3):67-74
15572874
J Intern Med. 2004 Sep;256(3):240-6
15324367
Br J Psychiatry. 2003 May;182:449-54
12724250
Can Med Assoc J. 1962 Feb 10;86:257-60
14459267
Neurology. 1993 Nov;43(11):2412-4
8232972