title: Calcium pre-rinse greatly increases overnight salivary fluoride after a 228 ppm fluoride rinse.
abstract: BACKGROUND
  Large increases in salivary fluoride were reported 1 h after a calcium pre-rinse/NaF rinse.
  
  
  OBJECTIVE
  This study examined the persistence of these increases.
  
  
  METHODS
  12 subjects rinsed in the evening with water, with a 228 microg/g (ppm) F rinse or with 150 mmol/l calcium lactate followed by a 228 microg/g F rinse. In a second experiment these same patients rinsed with a 912 microg/g F rinse. Saliva samples were obtained the morning after rinsing, centrifuged and the supernatants analyzed.
  
  
  RESULTS
  The Ca pre-rinse/228 microg/g F rinse induced an increase in overnight salivary F over the 912 microg/g F rinse (approximately 2.5 times) and a statistically significant increase over the 228 mug/g F rinse (approximately 5.5 times).
  
  
  CONCLUSIONS
  The results suggest that a Ca pretreatment may increase the cariostatic effect of topical F agents.
authors.affiliation: American Dental Association Foundation, Paffenbarger Research Center, Gaithersburg, MD 20899-8546, USA. jvogel@nist.gov
authors.forename: G L
authors.initials: GL
authors.lastname: Vogel
authors.forename: L C
authors.initials: LC
authors.lastname: Chow
authors.forename: C M
authors.initials: CM
authors.lastname: Carey
mesh_terms: D000328:Adult; D000368:Aged; D017610:Calcium Compounds / Q000627:therapeutic use*; D002327:Cariostatic Agents / Q000032:analysis / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005260:Female; D005459:Fluorides / Q000032:analysis / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006801:Humans; D007773:Lactates / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes / Q000627:therapeutic use*; D012463:Saliva / Q000737:chemistry / Q000378:metabolism*; D012636:Secretory Rate / Q000502:physiology; D013997:Time Factors; D014867:Water; D055815:Young Adult
chemical_list: D017610:Calcium Compounds; D002327:Cariostatic Agents; D007773:Lactates; D009067:Mouthwashes; D014867:Water; C110051:calcium lactate; D005459:Fluorides
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