High-sensitivity C-reactive protein: discriminator between patients with primary and secondary antiphospholipid syndrome.
OBJECTIVE
It is not clear whether primary (PAPS) or secondary (SAPS) antiphospholipid syndrome represent distinct clinical entities or whether they are the same syndrome seen against different background. Therefore we examined whether hsCRP, C3, C4 and anti-oxLDL antibodies could discriminate between PAPS and SAPS patients.


METHODS
This study included: 44 patients with PAPS and 20 patients with SAPS associated with SLE and 37 control subjects. Antibody levels were estimated by ELISA, while C3, C4 and hsCRP were determined by immunonephelometric method.


RESULTS
SAPS patients had significantly elevated hsCRP (mg/L) concentrations in comparison to PAPS patients (8.00 (7.00-15.00) vs. 2.27 (0.68-6.89), Mann-Whitney, p=0.000).


CONCLUSIONS
Measurement of hsCRP should be mandatory in the follow-up of SAPS patients in order to identify a subset with a high cardiovascular risk and in PAPS in order to identify patients with a risk of evolving to SLE.
Bećarević
Mirjana
M
Institute for Medical Biochemistry, Clinical Center of Serbia, Visegradska 26, 11000 Belgrade, Serbia. bmyrjana@yahoo.co.uk
Majkić-Singh
Nada
N
D000293:Adolescent; D000328:Adult; D000368:Aged; D017152:Antibodies, Antiphospholipid / Q000097:blood / Q000276:immunology; D016736:Antiphospholipid Syndrome / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D002097:C-Reactive Protein / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000209:etiology / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D055815:Young Adult
D017152:Antibodies, Antiphospholipid; D002097:C-Reactive Protein