title: Treatment of intrabony periodontal defects with enamel matrix derivative in private practice: a long-term retrospective study.
abstract: The present study describes treatment of intrabony periodontal defects with enamel matrix derivative (EMD) in private practice. Ten patients with clinical diagnosis of chronic periodontitis were subjected to data analysis. A total of 18 teeth with various osseous defects received regenerative therapy with EMD, and were followed for a minimum of 2 years. Treatment of the intrabony defects with EMD led to a statistically significant improvement in the mean value of probing depth at 1-year when compared with at the baseline (p<0.01). Reduction in probing depth was achieved with minimal recession of the gingival margin, and was maintained over the 2-year observation period with no significant change. Mean values of attachment gain at 1 and 2 years were of clinical significance: 3.39+/-1.46 mm and 3.22+/-1.40 mm, respectively. Although one tooth was extracted because of subsequent loss of attachment and bone, most teeth treated have been successfully maintained for 2 to 7 years with no significant signs of disease progression. In conclusion, EMD treatment of intrabony osseous defects yielded clinically favorable responses. The gain in clinical attachment can be longitudinally maintained in a private practice setting. Further controlled studies are needed to elucidate the clinical significance of EMD treatment.
authors.affiliation: Division of Conservative Dentistry, Department of Clinical Oral Health Science, Tokyo Dental College, Chiba, Japan. atsaito@tdc.ac.jp
authors.forename: Atsushi
authors.initials: A
authors.lastname: Saito
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Nanbu
authors.forename: Tomoko
authors.initials: T
authors.lastname: Nagahata
authors.forename: Satoru
authors.initials: S
authors.lastname: Yamada
mesh_terms: D000368:Aged; D016301:Alveolar Bone Loss / Q000601:surgery*; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D012534:Dental Scaling; D005260:Female; D005500:Follow-Up Studies; D005889:Gingival Recession / Q000601:surgery; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D019558:Occlusal Adjustment; D017622:Periodontal Attachment Loss / Q000601:surgery; D010514:Periodontal Pocket / Q000601:surgery; D010518:Periodontitis / Q000601:surgery; D011331:Private Practice; D012189:Retrospective Studies; D016745:Root Planing; D014086:Tooth Mobility / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D003746:Dental Enamel Proteins; C109069:enamel matrix proteins