Control of salicylate intolerance with fish oils.
We report three patients with disabling salicylate-induced intolerance who experienced abrogation of symptoms following dietary supplementation with omega-3 polyunsaturated fatty acids (PUFAs). All three patients experienced severe urticaria, asthma requiring systemic steroid therapy and anaphylactic reactions. After dietary supplementation with 10 g daily of fish oils rich in omega-3 PUFAs for 6-8 weeks all three experienced complete or virtually complete resolution of symptoms allowing discontinuation of systemic corticosteroid therapy. Symptoms relapsed after dose reduction. Fish oil appears a safe and effective treatment for this difficult and often serious condition.
Healy
E
E
Dermatopharmacology Unit, Southampton University Hospitals Trust, Southampton SO16 6YD, UK.
Newell
L
L
Howarth
P
P
Friedmann
P S
PS
D000328:Adult; D019587:Dietary Supplements; D004342:Drug Hypersensitivity / Q000188:drug therapy*; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use*; D005260:Female; D005395:Fish Oils / Q000627:therapeutic use*; D006801:Humans; D020156:Salicylic Acid / Q000009:adverse effects*; D016896:Treatment Outcome
D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D020156:Salicylic Acid