Association of antipsychotic induced weight gain and body mass index with GNB3 gene: a meta-analysis.
It has been reported that C825T variant in the gene encoding the G-protein subunit beta3 (GNB3) is associated with antipsychotic-induced weight gain and obesity. We investigated the association of the GNB3 and antipsychotic-induced weight gain as well as body mass index (BMI) using meta-analytical techniques. Our analysis of 402 schizophrenia subjects showed a trend (p=0.072) only under a fixed-model. As it was observed heterogeneity among the studies (p=0.007), we re-analyzed using a random-effects framework and no significance was found (p=0.339). No evidence for bias publication was reported (p=0.868). Our analysis of 18,903 subjects showed a trend (p=0.053) associating CC and lower BMI under a fixed model. Although no significant association was found, the same pattern (CC and lower antipsychotic-induced weight gain) was observed. Our meta-analysis indicates that firmly establishing the role of pharmacogenetics in clinical psychiatry requires much larger sample sizes that have been reported.
Souza
Renan P
RP
Neurogenetics Section, Centre for Addiction and Mental Health, University of Toronto, Canada.
De Luca
Vincenzo
V
Muscettola
Giovanni
G
Rosa
Daniela V F
DV
de Bartolomeis
Andrea
A
Romano Silva
Marco
M
Kennedy
James L
JL
D014150:Antipsychotic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D015992:Body Mass Index; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy / Q000503:physiopathology; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D015430:Weight Gain / Q000187:drug effects* / Q000235:genetics*
D014150:Antipsychotic Agents; C454420:G-protein beta3 subunit; D020962:Heterotrimeric GTP-Binding Proteins