Metabolomics-based methods for early disease diagnostics.
The emerging field of metabolomics, in which a large number of small-molecule metabolites from body fluids or tissues are detected quantitatively in a single step, promises immense potential for early diagnosis, therapy monitoring and for understanding the pathogenesis of many diseases. Metabolomics methods are mostly focused on the information-rich analytical techniques of NMR spectroscopy and mass spectrometry (MS). Analysis of the data from these high-resolution methods using advanced chemometric approaches provides a powerful platform for translational and clinical research and diagnostic applications. In this review, the current trends and recent advances in NMR- and MS-based metabolomics are described with a focus on the development of advanced NMR and MS methods, improved multivariate statistical data analysis and recent applications in the area of cancer, diabetes, inborn errors of metabolism and cardiovascular diseases.
Gowda
G A Nagana
GA
Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA. ngowda@purdue.edu
Zhang
Shucha
S
Gu
Haiwei
H
Asiago
Vincent
V
Shanaiah
Narasimhamurthy
N
Raftery
Daniel
D
D000818:Animals; D004194:Disease; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D055432:Metabolomics / Q000379:methods*; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D013997:Time Factors
Breast Cancer Res Treat. 2007 Aug;104(2):181-9
17061040
Analyst. 2002 Oct;127(10):1283-8
12430596
Clin Chem. 2004 Jan;50(1):58-66
14633929
NMR Biomed. 2005 May;18(3):143-62
15627238
NMR Biomed. 2006 Feb;19(1):30-40
16229059
J Clin Invest. 1997 May 1;99(9):2219-24
9151794
Mass Spectrom Rev. 2005 Sep-Oct;24(5):613-46
15389842
Angew Chem Int Ed Engl. 2007;46(4):580-3
17080471
Biochem Biophys Res Commun. 2003 Oct 24;310(3):943-8
14550295
Rapid Commun Mass Spectrom. 2006;20(10):1577-84
16628593
J Magn Reson. 2008 Jan;190(1):1-6
17945521
J Urol. 2006 Nov;176(5):2274-9
17070311
J Proteome Res. 2005 Sep-Oct;4(5):1493-502
16212399
J Clin Invest. 1996 Jun 15;97(12):2859-65
8675698
NMR Biomed. 2008 Feb;21(2):175-85
17542042
J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Dec 25;813(1-2):47-52
15556514
Cancer Res. 1998 May 1;58(9):1825-32
9581820
Am J Respir Crit Care Med. 2005 Jun 1;171(11):1286-91
15750044
Drug Discov Today. 2003 Nov 15;8(22):1021-2
14690631
J Pharm Biomed Anal. 1998 May;17(1):125-32
9608434
Anal Bioanal Chem. 2004 Mar;378(6):1403-4
15214401
Anal Chem. 2008 Jan 1;80(1):143-9
18044958
Breast J. 2003 May-Jun;9(3):184-91
12752626
Rapid Commun Mass Spectrom. 2006;20(8):1192-8
16541414
Chem Commun (Camb). 2006 May 21;(19):2042-4
16767269
Physiol Genomics. 2006 Oct 11;27(2):178-86
16868074
NMR Biomed. 2005 Jun;18(4):252-9
15884096
Clin Chem. 1985 Nov;31(11):1795-801
2996806
Chem Rev. 1999 Oct 13;99(10):3133-3152
11749512
Ann Clin Biochem. 2003 Jan;40(Pt 1):16-24
12542907
Pac Symp Biocomput. 2007;:181-92
17990491
Eur J Clin Invest. 2002 Jun;32 Suppl 3:14-23
12028371
Anal Chem. 2006 Jan 15;78(2):363-71
16408915
Cancer Res. 2006 Nov 15;66(22):10795-804
17108116
Anal Chem. 2007 Jan 1;79(1):89-97
17194125
BMC Cancer. 2007 Jan 17;7:11
17233882
Int J Mol Med. 2007 Aug;20(2):199-208
17611638
J Proteome Res. 2007 Feb;6(2):498-505
17269706
Anal Biochem. 2008 Dec 1;383(1):76-84
18775407
Anal Chem. 2004 Jul 1;76(13):3666-74
15228339
Physiol Genomics. 2007 Apr 24;29(2):99-108
17190852
Cancer Biomark. 2007;3(2):95-109
17522431
Genome Biol. 2003;4(12):241
14659011
Rapid Commun Mass Spectrom. 2006;20(19):2800-6
16941721
MAGMA. 2004 Mar;16(4):174-81
14999565
Cancer Res. 2005 Apr 15;65(8):3030-4
15833828
Am J Transplant. 2005 Dec;5(12):2814-20
16302993
J Proteome Res. 2005 Mar-Apr;4(2):591-8
15822939
Anal Chem. 2005 Jul 1;77(13):4108-16
15987116
Anal Chem. 2005 Dec 1;77(23):7717-23
16316181
Mol Biosyst. 2006 Mar;2(3-4):174-83
16880935
J Neurosurg. 2002 Jun;96(6):1023-31
12066902
Nat Med. 2002 Dec;8(12):1439-44
12447357
Analyst. 2003 Jan;128(1):32-6
12572799
Toxicol Sci. 2005 Jun;85(2):809-22
15689416
Pharm Res. 2006 Jun;23(6):1075-88
16715371
Curr Top Med Chem. 2002 Jan;2(1):35-51
11899064
NMR Biomed. 2000 Apr;13(2):64-71
10797634
Anal Chem. 2006 Apr 15;78(8):2700-9
16615782
Cancer. 2007 Aug 15;110(4):835-44
17599760
Cancer Sci. 2007 Nov;98(11):1678-82
17727683
Anal Biochem. 2004 Feb 15;325(2):260-72
14751261
FEBS Lett. 2001 Apr 6;494(1-2):112-6
11297745
Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12511-6
16895997
Clin Chem. 2002;48(4):660-2
11901070
Nat Protoc. 2007;2(11):2692-703
18007604
NMR Biomed. 2004 Jun;17(4):191-205
15229932
Nat Rev Drug Discov. 2003 Aug;2(8):668-76
12904817
J Proteome Res. 2007 Jul;6(7):2605-14
17564425
MAGMA. 1999 May;8(2):121-8
10456375
NMR Biomed. 2005 Nov;18(7):421-9
16075416
Rapid Commun Mass Spectrom. 2006;20(22):3295-302
17044115
J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Apr 15;849(1-2):105-14
17097359
Nucleic Acids Res. 2007 Jan;35(Database issue):D521-6
17202168
Anal Chem. 2005 Apr 15;77(8):2455-63
15828781
J Magn Reson. 2004 Oct;170(2):329-35
15388097
Arterioscler Thromb Vasc Biol. 2002 Jul 1;22(7):1175-80
12117734
Magn Reson Med. 2003 Nov;50(5):944-54
14587005
NMR Biomed. 2002 Aug;15(5):327-37
12203224
Expert Rev Mol Diagn. 2004 Mar;4(2):189-99
14995905
Prostate. 2008 May 1;68(6):620-8
18213632
Curr Opin Drug Discov Devel. 2005 Jan;8(1):127-33
15679180
Clin Chim Acta. 2002 Oct;324(1-2):121-8
12204433
J Pharm Biomed Anal. 2005 Aug 10;38(5):824-32
16087044
J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Mar 5;817(1):67-76
15680789
Clin Chem Lab Med. 2008;46(1):27-42
18020967
BMC Bioinformatics. 2007 Oct 29;8:419
17963529
Int J Cancer. 2005 Feb 20;113(5):782-8
15499633
Philos Trans R Soc Lond B Biol Sci. 2006 Jan 29;361(1465):147-61
16553314
Annu Rev Med. 1999;50:277-90
10073278
Magn Reson Med. 2006 Jun;55(6):1257-64
16685733
J Magn Reson. 1998 Nov;135(1):194-202
9799694
J Proteome Res. 2006 Oct;5(10):2642-55
17022635
Anal Bioanal Chem. 2007 Jan;387(2):539-49
16821030
Anal Bioanal Chem. 2007 Jan;387(2):525-7
16955259
Nat Med. 2006 Jun;12(6):705-10
16732278
Lancet. 1999 Jun 5;353(9168):1930-3
10371572
Curr Opin Microbiol. 2004 Jun;7(3):296-307
15196499
Xenobiotica. 1999 Nov;29(11):1181-9
10598751
BMC Bioinformatics. 2005 Jul 18;6:179
16026613
FEBS Lett. 2006 Dec 22;580(30):6837-45
17141227
Plant Mol Biol. 2002 Jan;48(1-2):155-71
11860207
Lipids. 2006 Jun;41(6):591-603
16981437
Science. 2004 Oct 15;306(5695):471-3
15486296
Anal Chem. 2002 May 15;74(10):2261-73
12038750
Clin Chem. 1991 Mar;37(3):377-86
2004444
Neurol Neurochir Pol. 2003 Jan-Feb;37(1):123-32
12910835
Expert Rev Mol Diagn. 2006 Sep;6(5):717-31
17009906
Anal Chem. 2005 Mar 1;77(5):1282-9
15732908
Anal Chem. 2008 Jan 15;80(2):421-9
18085752
Clin Chem. 1998 Jul;44(7):1529-34
9665433
Magn Reson Med. 2006 Oct;56(4):738-44
16972311
Mol Syst Biol. 2006;2:52
17016518
Pharmacol Ther. 2006 Jan;109(1-2):92-106
16051371
Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11540-4
17606902
MAGMA. 2006 Dec;19(6):281-96
17171386
Respir Res. 2005 Jul 14;6:71
16018807
Anal Chem. 2005 Apr 15;77(8):2297-302
15828760
Mass Spectrom Rev. 2007 May-Jun;26(3):403-31
17405143
Anal Biochem. 2003 Nov 1;322(1):134-8
14705791
FEBS J. 2007 Mar;274(5):1132-9
17298437
Anal Bioanal Chem. 2007 Jan;387(2):533-7
17131108
Anal Biochem. 2007 Apr 15;363(2):185-95
17316536
Technol Cancer Res Treat. 2004 Dec;3(6):591-8
15560717
Anticancer Res. 2007 Sep-Oct;27(5A):3195-204
17970061
Mass Spectrom Rev. 2005 Mar-Apr;24(2):223-31
15389859
Anal Chem. 2007 Jan 15;79(2):464-76
17222009