title: Albumin competitively inhibits glycation of less abundant proteins.
abstract: Glycation, a non-enzymatic reaction between glucose and protein is the primary cause of diabetic complications. Albumin, the most abundant plasma protein undergoes glycation both in vivo and in vitro. The influence of albumin on glycation of less abundant proteins has not been addressed. For the first time, we show that albumin competitively inhibits the glycation of less abundant proteins. This study suggests that at least in the initial stages of diabetes, albumin may protect other proteins from glycation.
authors.affiliation: Division of Organic Chemistry, National Chemical Laboratory, Pune, India.
authors.forename: Hemangi S
authors.initials: HS
authors.lastname: Bhonsle
authors.forename: Sameer Kumar
authors.initials: SK
authors.lastname: Singh
authors.forename: Ghanshyam
authors.initials: G
authors.lastname: Srivastava
authors.forename: Ramanamurthy
authors.initials: R
authors.lastname: Boppana
authors.forename: Mahesh J
authors.initials: MJ
authors.lastname: Kulkarni
mesh_terms: D001059:Apoproteins / Q000737:chemistry / Q000378:metabolism; D001667:Binding, Competitive; D002256:Carbonic Anhydrases / Q000378:metabolism; D048909:Diabetes Complications / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000737:chemistry / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D066298:In Vitro Techniques; D007328:Insulin / Q000737:chemistry / Q000378:metabolism; D007700:Kinetics; D009211:Myoglobin / Q000737:chemistry / Q000378:metabolism; D010206:Papain / Q000378:metabolism; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D012709:Serum Albumin / Q000737:chemistry* / Q000378:metabolism*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D001059:Apoproteins; D017127:Glycation End Products, Advanced; D007328:Insulin; D009211:Myoglobin; D011506:Proteins; D012709:Serum Albumin; C010857:apomyoglobin; D010206:Papain; D002256:Carbonic Anhydrases