Derivatives of reactive oxygen metabolites correlates with high-sensitivity C-reactive protein.
OBJECTIVE
High-sensitivity C-reactive protein (hsCRP) is a predictor of cardiovascular events. Although oxidative stress may also be related to cardiovascular disease, there are few studies comparing the two. We therefore examined the association of hsCRP, serum lipids, and derivatives of reactive oxygen metabolites (D-ROMs) in coronary artery disease.


METHODS
We measured the levels of serum lipids, hsCRP, plasma brain natriuretic peptides (BNP) and D-ROMs in 131 consecutive patients undergoing cardiac catheterization. We divided these subjects into three groups according to their levels of hsCRP.


RESULTS
In group C (hsCRP>3.0 mg/L), mean levels of serum D-ROMs were significantly higher than in groups A (hsCRP<1.0 mg/L) and B (hsCRP 1.0 to 3.0 mg/L). Serum levels of D-ROMs and log (hsCRP) correlated in the total population (r=0.479, p<0.0001), and D-ROMs, HDL-C, LDL-C and log-transformed plasma BNP were independent predictors of hsCRP (p<0.0001).


CONCLUSIONS
We concluded that oxidative stress increases in patients at high risk for cardiovascular events based on their hsCRP.
Kamezaki
Fumihiko
F
The Second Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Yamashita
Kazuhito
K
Kubara
Takahiro
T
Suzuki
Yoshiyuki
Y
Tanaka
Seiya
S
Rkouzuma
Ryouji
R
Okazaki
Masahiro
M
Tasaki
Hiromi
H
Otuji
Yutaka
Y
D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D006328:Cardiac Catheterization; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D017382:Reactive Oxygen Species / Q000378:metabolism*
D008055:Lipids; D017382:Reactive Oxygen Species; D020097:Natriuretic Peptide, Brain; D002097:C-Reactive Protein