title: Distribution of glucagon-like peptide-1 immunoreactivity in the hypothalamic paraventricular and supraoptic nuclei.
abstract: Glucagon-like peptide-1 (GLP-1) plays a role in modulating neuroendocrine and autonomic function. The hypothalamic paraventricular nucleus (PVN) contains aggregations of GLP-1 fibers and expresses GLP-1 receptors, making it a likely site of action for GLP-1 signaling. The current study was designed to establish domains of GLP-1 action, focusing on axosomatic appositions on different neuroendocrine and autonomic cell populations in the PVN. The data indicate abundant GLP-1-immunoreactive terminal appositions on corticotropin-releasing hormone neurons in the medial parvocellular PVN. GLP-1 positive boutons can also be observed in apposition to oxytocinergic neurons and on retrogradely labeled pre-autonomic neurons projecting to the region of the nucleus of the solitary tract. In contrast, there were very few vasopressinergic neurons with GLP-1 appositions. Overall, the data indicate that the central GLP-1 system preferentially targets neurons in hypophysiotrophic zones of the PVN, consistent with excitatory actions of GLP-1 on adrenocorticotropin release. GLP-1 is also in position to influence oxytocin secretion and control outflow to brainstem cardiovascular relays.
authors.affiliation: Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45237, United States.
authors.forename: Miyuki
authors.initials: M
authors.lastname: Tauchi
authors.forename: Rong
authors.initials: R
authors.lastname: Zhang
authors.forename: David A
authors.initials: DA
authors.lastname: D'Alessio
authors.forename: Javier E
authors.initials: JE
authors.lastname: Stern
authors.forename: James P
authors.initials: JP
authors.lastname: Herman
mesh_terms: D000315:Adrenalectomy; D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism*; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D009412:Nerve Fibers / Q000378:metabolism; D009481:Neurophysins / Q000378:metabolism; D010121:Oxytocin / Q000378:metabolism; D010286:Paraventricular Hypothalamic Nucleus / Q000166:cytology / Q000378:metabolism*; D017729:Presynaptic Terminals / Q000378:metabolism; D051381:Rats; D020318:Rats, Long-Evans; D017207:Rats, Sprague-Dawley; D013495:Supraoptic Nucleus / Q000166:cytology / Q000378:metabolism*
chemical_list: D009481:Neurophysins; D001127:Arginine Vasopressin; D010121:Oxytocin; D052216:Glucagon-Like Peptide 1; D003346:Corticotropin-Releasing Hormone
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