Respiratory muscle strength predicts decline in mobility in older persons.
OBJECTIVE
To test the hypothesis that respiratory muscle strength is associated with the rate of change in mobility even after controlling for leg strength and physical activity.


METHODS
Prospective study of 890 ambulatory older persons without dementia who underwent annual clinical evaluations to examine change in the rate of mobility over time.


RESULTS
In a linear mixed-effect model adjusted for age, sex, and education, mobility declined about 0.12 unit/year, and higher levels of respiratory muscle strength were associated with a slower rate of mobility decline (estimate 0.043, SE 0.012, p < 0.001). Respiratory muscle strength remained associated with the rate of change in mobility even after controlling for lower extremity strength (estimate 0.036, SE 0.012, p = 0.004). In a model that included terms for respiratory muscle strength, lower extremity strength and physical activity together, all three were independent predictors of mobility decline in older persons. These associations remained significant even after controlling for body composition, global cognition, the development of dementia, parkinsonian signs, possible pulmonary disease, smoking, joint pain and chronic diseases.


CONCLUSIONS
Respiratory muscle strength is associated with mobility decline in older persons independent of lower extremity strength and physical activity. Clinical interventions to improve respiratory muscle strength may decrease the burden of mobility impairment in the elderly.
Buchman
A S
AS
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA. Aron_S_Buchman@rush.edu
Boyle
P A
PA
Wilson
R S
RS
Leurgans
S
S
Shah
R C
RC
Bennett
D A
DA
D000368:Aged; D000375:Aging / Q000502:physiology*; D002641:Chicago; D006801:Humans; D007866:Leg / Q000502:physiology; D008137:Longitudinal Studies; D008568:Memory / Q000502:physiology*; D051346:Mobility Limitation; D009043:Motor Activity / Q000502:physiology; D053580:Muscle Strength / Q000502:physiology*; D010809:Physical Fitness; D011237:Predictive Value of Tests; D012132:Respiratory Muscles / Q000502:physiology*; D014505:Urban Population
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