title: Programmed regulation of conformational switching in diagnostic biomolecular automata using error control molecules.
abstract: We aim to present novel biomolecular automata for transcriptome diagnosis. We already proposed several biomolecular probes for the prediction of oral squamous cell carcinoma as a model case and evaluated the system noise and sensitivity. Here we introduce an error control element and discuss the specificity of the system.
authors.affiliation: Department of Quantum Engineering and Systems Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-8656, Japan. miki@crimson.q.t.u-tokyo.ac.jp
authors.forename: Miki
authors.initials: M
authors.lastname: Hirabayashi
authors.forename: Hirotada
authors.initials: H
authors.lastname: Ohashi
authors.forename: Tai
authors.initials: T
authors.lastname: Kubo
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000235:genetics*; D005456:Fluorescent Dyes / Q000737:chemistry; D005786:Gene Expression Regulation; D006801:Humans; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000235:genetics*; D009690:Nucleic Acid Conformation; D015345:Oligonucleotide Probes / Q000737:chemistry*; D012333:RNA, Messenger / Q000032:analysis*; D012394:Rosaniline Dyes / Q000737:chemistry; D012680:Sensitivity and Specificity; D014158:Transcription, Genetic
chemical_list: D052157:Aptamers, Nucleotide; D005456:Fluorescent Dyes; D015345:Oligonucleotide Probes; D012333:RNA, Messenger; D012394:Rosaniline Dyes; C005095:malachite green