title: New butyrylcholinesterase inhibitory steroid and peroxy acid from Leucas urticifolia.
abstract: A new steroid leucisterol (1) and a new peroxy acid urticic acid (2) along with methoxybenzyl benzoate (3), 4-hydroxy benzoic acid (4), beta-sitosterol (5), and ursolic acid (6), have been isolated from the chloroform soluble fraction of the whole plant of Leucas urticifolia. Their structures were elucidated on the basis of nuclear magnetic resonance (1D and 2D NMR) spectral data. Leucisterol showed potent inhibitory activity against butyrylcholinesterase enzyme.
authors.affiliation: International Center for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.
authors.forename: Itrat
authors.initials: I
authors.lastname: Fatima
authors.forename: Ijaz
authors.initials: I
authors.lastname: Ahmad
authors.forename: Itrat
authors.initials: I
authors.lastname: Anis
authors.forename: Abdul
authors.initials: A
authors.lastname: Malik
authors.forename: Nighat
authors.initials: N
authors.lastname: Afza
authors.forename: Lubna
authors.initials: L
authors.lastname: Iqbal
authors.forename: Mehreen
authors.initials: M
authors.lastname: Latif
mesh_terms: D002091:Butyrylcholinesterase / Q000378:metabolism*; D002800:Cholinesterase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D005229:Fatty Acids, Monounsaturated / Q000302:isolation & purification / Q000494:pharmacology*; D019686:Lamiaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008970:Molecular Weight; D010545:Peroxides / Q000302:isolation & purification / Q000494:pharmacology*; D010840:Phytosterols / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013256:Steroids / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D002800:Cholinesterase Inhibitors; D005229:Fatty Acids, Monounsaturated; D010545:Peroxides; D010840:Phytosterols; D010936:Plant Extracts; D013256:Steroids; C532261:leucisterol; C532262:urticic acid; D002091:Butyrylcholinesterase