Isolated populations and complex disease gene identification.
The utility of genetically isolated populations (population isolates) in the mapping and identification of genes is not only limited to the study of rare diseases; isolated populations also provide a useful resource for studies aimed at improved understanding of the biology underlying common diseases and their component traits. Well characterized human populations provide excellent study samples for many different genetic investigations, ranging from genome-wide association studies to the characterization of interactions between genes and the environment.
Kristiansson
Kati
K
National Public Health Institute and FIMM, Institute for Molecular Medicine Finland, Helsinki 00300, Finland.
Naukkarinen
Jussi
J
Peltonen
Leena
L
D000483:Alleles; D004194:Disease / Q000235:genetics*; D018703:Founder Effect; D018740:Genetic Heterogeneity; D014644:Genetic Variation; D023281:Genomics; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D012934:Social Isolation
Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2228-33
11842208
N Engl J Med. 2008 Apr 17;358(16):1682-91
18403759
Nat Genet. 2007 Apr;39(4):513-6
17322881
Psychiatr Genet. 2007 Jun;17(3):159-63
17417059
Nature. 2003 Dec 18;426(6968):789-96
14685227
Nat Genet. 1999 Dec;23(4):397-404
10581024
Hum Mol Genet. 2003 Apr 1;12(7):771-6
12651872
Lancet. 1990 Jul 7;336(8706):13-6
1973210
Hum Hered. 1998 May-Jun;48(3):138-54
9618061
Eur J Hum Genet. 2007 Mar;15(3):302-12
17202997
Nat Genet. 2008 Feb;40(2):217-24
18176561
J Clin Invest. 2008 Jul;118(7):2620-8
18521185
Mol Psychiatry. 2007 Nov;12(11):1033-41
17440433
Hum Genet. 2003 May;112(5-6):441-56
12627295
Neurology. 2008 Jun 10;70(24):2277-83
18434642
PLoS Genet. 2007 Jul;3(7):e115
17658951
Nat Rev Genet. 2006 May;7(5):395-401
16534512
Nat Genet. 2008 Jul;40(7):835-7
18488028
Nat Genet. 2008 Feb;40(2):198-203
18193045
Hum Mol Genet. 1999;8(10):1913-23
10469845
Nucleic Acids Res. 2001 Jan 1;29(1):308-11
11125122
Eur J Hum Genet. 2008 Jan;16(1):105-14
17805225
Science. 2007 Jun 1;316(5829):1341-5
17463248
Hum Mol Genet. 2007 Oct 15;16(20):2517-28
17673452
Fam Cancer. 2004;3(3-4):201-6
15516842
Eur Respir J. 2006 Dec;28(6):1258-63
17138680
Nat Genet. 2004 Apr;36(4):371-6
14991056
Eur J Hum Genet. 2005 Jun;13(6):698-706
15785775
Science. 2002 Jun 21;296(5576):2225-9
12029063
Obesity (Silver Spring). 2008 Apr;16(4):908-12
18239581
Hypertension. 2008 Apr;51(4):1156-62
18259002
J Med Genet. 2008 Sep;45(9):572-7
18550697
Nature. 2007 Jul 19;448(7151):353-7
17603472
Nat Genet. 2008 Jun;40(6):703-6
18438407
Nat Genet. 2003 Feb;33(2):177-82
12524541
Am J Hum Genet. 1997 Dec;61(6):1335-41
9399900
Ann Hum Genet. 2003 Jul;67(Pt 4):281-97
12914564
J Med Genet. 2003 Dec;40(12):925-32
14684692
Am J Med Genet B Neuropsychiatr Genet. 2009 Mar 5;150B(2):191-201
18444255
Diabetes Care. 2006 Aug;29(8):1866-71
16873794
Nat Genet. 2007 May;39(5):650-4
17417636
Nat Genet. 2007 Aug;39(8):977-83
17603485
Hum Mol Genet. 2001 Jul 15;10(15):1611-7
11468279
Diabetes. 2007 Oct;56(10):2643-8
17646211
Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2736-42
17885212
PLoS Genet. 2006 May;2(5):e69
16699592
Nat Genet. 2007 Dec;39(12):1443-52
17952075
Nat Genet. 2008 Mar;40(3):281-3
18264098
Nat Genet. 2006 Jun;38(6):663-7
16715096
Science. 2007 Sep 7;317(5843):1397-400
17690259
Science. 2007 Feb 9;315(5813):848-53
17289997
Science. 2004 Apr 9;304(5668):300-4
15073379
Science. 2007 Jun 8;316(5830):1491-3
17478679
Nat Genet. 2006 Mar;38(3):320-3
16415884
Hum Mol Genet. 2005 Sep 1;14(17):2595-605
16076849
Eur J Hum Genet. 2007 Sep;15(9):911-6
17568393
Nat Genet. 2005 Dec;37(12):1320-2
16258542
Science. 2004 Aug 6;305(5685):869-72
15297675
Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14747-52
17804789
Nat Genet. 2007 Jul;39(7):865-9
17529974
Nat Genet. 2008 Mar;40(3):340-5
18246066
Nature. 2007 Jun 7;447(7145):661-78
17554300
Genetics. 2006 Oct;174(2):959-84
16888333
Am J Hum Genet. 1995 May;56(5):1088-95
7726163
Nat Genet. 2006 May;38(5):556-60
16582909
Nat Genet. 1999 Jun;22(2):139-44
10369254
Nature. 2008 Apr 3;452(7187):638-642
18385739
Am J Med Genet B Neuropsychiatr Genet. 2004 Jul 1;128B(1):65-70
15211634
Clin Genet. 2002 Apr;61(4):233-47
12030885
Nature. 2001 Feb 15;409(6822):860-921
11237011
Mol Psychiatry. 2003 Jul;8(7):695-705, 643
12874606
Nat Genet. 2001 Oct;29(2):233-7
11586306
Hum Genet. 2003 Dec;114(1):1-10
13680359
Mol Psychiatry. 2002;7(7):689-94
12192612
Diabetes. 2004 May;53(5):1181-6
15111484
Nat Genet. 2008 May;40(5):609-15
18391951
Am J Hum Genet. 2007 Sep;81(3):615-25
17701907
N Engl J Med. 2008 May 29;358(22):2355-65
18445777
Hum Mol Genet. 2006 Nov 1;15(21):3146-53
16984960
Hum Mol Genet. 2003 Dec 1;12(23):3151-9
14532331
Am J Hum Genet. 2005 Feb;76(2):237-48
15614721
Nat Genet. 2004 Mar;36(3):233-9
14770184
Am J Hum Genet. 2007 Jun;80(6):1103-14
17503328
Nat Genet. 2007 Jun;39(6):770-5
17460697
Am J Med Genet A. 2008 Apr 15;146A(8):1072-87
18348259
Trends Genet. 2003 Mar;19(3):135-40
12615007