title: Hypocalcemia in a patient with osteosarcoma and 22q11.2 deletion syndrome.
abstract: Hypocalcemia is a rare complication of osteosarcoma, having been described in only 4 reports. We present the case of a 16-year-old male with metastatic osteosarcoma of the right humerus who was found to have severe asymptomatic hypocalcemia. Cytogenetic analysis of peripheral blood revealed a microdeletion in band 22q11.2. Following amputation of the tumor-bearing extremity, the patient's calcium levels increased, but did not normalize. These findings suggested that the etiology of his hypocalcemia was osteoblastic utilization of calcium by the tumor, exacerbated by 22q11.2 deletion syndrome.
authors.affiliation: Pediatric Oncology Branch, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Francis J
authors.initials: FJ
authors.lastname: Mussai
authors.forename: Lea C
authors.initials: LC
authors.lastname: Cunningham
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Rezvani
authors.forename: Constantine A
authors.initials: CA
authors.lastname: Stratakis
authors.forename: James C
authors.initials: JC
authors.lastname: Reynolds
authors.forename: Galina
authors.initials: G
authors.lastname: Nesterova
authors.forename: Robert M
authors.initials: RM
authors.lastname: Henshaw
authors.forename: Jason E
authors.initials: JE
authors.lastname: Levine
authors.forename: Lee J
authors.initials: LJ
authors.lastname: Helman
authors.forename: Diane C
authors.initials: DC
authors.lastname: Arthur
authors.forename: Su Young
authors.initials: SY
authors.lastname: Kim
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D000671:Amputation, Surgical; D001859:Bone Neoplasms / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D004062:DiGeorge Syndrome / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D006811:Humerus / Q000473:pathology / Q000601:surgery; D006996:Hypocalcemia / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D017403:In Situ Hybridization; D008297:Male; D012516:Osteosarcoma / Q000150:complications* / Q000473:pathology / Q000503:physiopathology
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