Successful childbirth in a patient with chronic myelogenous leukemia treated with imatinib mesylate during early pregnancy.
OBJECTIVE
To report a case of successful pregnancy in a patient with chronic myelogenous leukemia treated with imatinib mesylate for the first 4 months of pregnancy.


RESULTS
Imatinib mesylate is potentially teratogenic and its use during pregnancy in humans can lead to abortion or development of fetal abnormalities in nearly 40% of fully reported cases. We report a case of a 28-year-old woman who delivered a healthy child of normal weight after having been treated with imatinib for Ph1-positive CML during the first four months of her pregnancy. She refused advocated interruption and for the rest of the pregnancy was treated with interferon. The treatment was associated with a rapid 2-log increase in the leukemia clone measured by the real-time polymerase chain reaction. Reintroduction of imatinib after delivery resulted in achievement of the complete cytogenetic response again.


CONCLUSIONS
We discuss possible strategies for successful management of pregnancy in CML patients treated with imatinib.
Skoumalova
Ivana
I
Department of Hemato-Oncology, Teaching Hospital Olomouc, Czech Republic.
Vondrakova
Jana
J
Rohon
Peter
P
Rozmanova
Sarka
S
Jarosova
Marie
M
Indrak
Karel
K
Prochazka
Martin
M
Santava
Alena
A
Faber
Edgar
E
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001549:Benzamides; D005260:Female; D006801:Humans; D000068877:Imatinib Mesylate; D007231:Infant, Newborn; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy*; D008297:Male; D036801:Parturition; D010879:Piperazines / Q000627:therapeutic use*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy*; D011256:Pregnancy Outcome; D011743:Pyrimidines / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate