title: A common human leucocyte antigen-DP genotype is associated with resistance to HIV-1 infection in Kenyan sex workers.
abstract: Human leucocyte antigen-DP presents peptides to CD4 T cells and plays an important role in parasitic infections and autoimmune diseases, yet its influence on HIV-1 susceptibility has not been well studied. Here, we report several human leucocyte antigen-DP genotypes associated with HIV-1 susceptibility in Kenyan sex workers. Among these, one common genotype stands out. DPA1*010301 (frequency = 60.4%) was associated with HIV-1 resistance (P = 0.033, odds ratio = 1.585, 95% confidence interval = 1.036-2.425) and slower seroconversion (P = 0.001, log rank = 0.595, 95% confidence interval = 0.433-0.817). The discovery of common human leucocyte antigen-DP genotypes contributing to HIV-1 immunity may help overcome difficulties encountered with highly polymorphic human leucocyte antigens.
authors.affiliation: Department of Medical Microbiology, University of Manitoba, Canada.
authors.forename: Rae-Anne
authors.initials: RA
authors.lastname: Hardie
authors.forename: Erin
authors.initials: E
authors.lastname: Knight
authors.forename: Brigitte
authors.initials: B
authors.lastname: Bruneau
authors.forename: Christina
authors.initials: C
authors.lastname: Semeniuk
authors.forename: Kulvinder
authors.initials: K
authors.lastname: Gill
authors.forename: Nico
authors.initials: N
authors.lastname: Nagelkerke
authors.forename: Joshua
authors.initials: J
authors.lastname: Kimani
authors.forename: Charles
authors.initials: C
authors.lastname: Wachihi
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Ngugi
authors.forename: Ma
authors.initials: M
authors.lastname: Luo
authors.forename: Francis A
authors.initials: FA
authors.lastname: Plummer
mesh_terms: D003430:Cross-Sectional Studies; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology / Q000635:transmission; D006679:HIV Seropositivity / Q000235:genetics; D015497:HIV-1; D006682:HLA-DP Antigens / Q000235:genetics*; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D011477:Sex Work
chemical_list: D006682:HLA-DP Antigens
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