title: Isolated populations and complex disease gene identification.
abstract: The utility of genetically isolated populations (population isolates) in the mapping and identification of genes is not only limited to the study of rare diseases; isolated populations also provide a useful resource for studies aimed at improved understanding of the biology underlying common diseases and their component traits. Well characterized human populations provide excellent study samples for many different genetic investigations, ranging from genome-wide association studies to the characterization of interactions between genes and the environment.
authors.affiliation: National Public Health Institute and FIMM, Institute for Molecular Medicine Finland, Helsinki 00300, Finland.
authors.forename: Kati
authors.initials: K
authors.lastname: Kristiansson
authors.forename: Jussi
authors.initials: J
authors.lastname: Naukkarinen
authors.forename: Leena
authors.initials: L
authors.lastname: Peltonen
mesh_terms: D000483:Alleles; D004194:Disease / Q000235:genetics*; D018703:Founder Effect; D018740:Genetic Heterogeneity; D014644:Genetic Variation; D023281:Genomics; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D012934:Social Isolation
references.citation: Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2228-33
references.pmid: 11842208
references.citation: N Engl J Med. 2008 Apr 17;358(16):1682-91
references.pmid: 18403759
references.citation: Nat Genet. 2007 Apr;39(4):513-6
references.pmid: 17322881
references.citation: Psychiatr Genet. 2007 Jun;17(3):159-63
references.pmid: 17417059
references.citation: Nature. 2003 Dec 18;426(6968):789-96
references.pmid: 14685227
references.citation: Nat Genet. 1999 Dec;23(4):397-404
references.pmid: 10581024
references.citation: Hum Mol Genet. 2003 Apr 1;12(7):771-6
references.pmid: 12651872
references.citation: Lancet. 1990 Jul 7;336(8706):13-6
references.pmid: 1973210
references.citation: Hum Hered. 1998 May-Jun;48(3):138-54
references.pmid: 9618061
references.citation: Eur J Hum Genet. 2007 Mar;15(3):302-12
references.pmid: 17202997
references.citation: Nat Genet. 2008 Feb;40(2):217-24
references.pmid: 18176561
references.citation: J Clin Invest. 2008 Jul;118(7):2620-8
references.pmid: 18521185
references.citation: Mol Psychiatry. 2007 Nov;12(11):1033-41
references.pmid: 17440433
references.citation: Hum Genet. 2003 May;112(5-6):441-56
references.pmid: 12627295
references.citation: Neurology. 2008 Jun 10;70(24):2277-83
references.pmid: 18434642
references.citation: PLoS Genet. 2007 Jul;3(7):e115
references.pmid: 17658951
references.citation: Nat Rev Genet. 2006 May;7(5):395-401
references.pmid: 16534512
references.citation: Nat Genet. 2008 Jul;40(7):835-7
references.pmid: 18488028
references.citation: Nat Genet. 2008 Feb;40(2):198-203
references.pmid: 18193045
references.citation: Hum Mol Genet. 1999;8(10):1913-23
references.pmid: 10469845
references.citation: Nucleic Acids Res. 2001 Jan 1;29(1):308-11
references.pmid: 11125122
references.citation: Eur J Hum Genet. 2008 Jan;16(1):105-14
references.pmid: 17805225
references.citation: Science. 2007 Jun 1;316(5829):1341-5
references.pmid: 17463248
references.citation: Hum Mol Genet. 2007 Oct 15;16(20):2517-28
references.pmid: 17673452
references.citation: Fam Cancer. 2004;3(3-4):201-6
references.pmid: 15516842
references.citation: Eur Respir J. 2006 Dec;28(6):1258-63
references.pmid: 17138680
references.citation: Nat Genet. 2004 Apr;36(4):371-6
references.pmid: 14991056
references.citation: Eur J Hum Genet. 2005 Jun;13(6):698-706
references.pmid: 15785775
references.citation: Science. 2002 Jun 21;296(5576):2225-9
references.pmid: 12029063
references.citation: Obesity (Silver Spring). 2008 Apr;16(4):908-12
references.pmid: 18239581
references.citation: Hypertension. 2008 Apr;51(4):1156-62
references.pmid: 18259002
references.citation: J Med Genet. 2008 Sep;45(9):572-7
references.pmid: 18550697
references.citation: Nature. 2007 Jul 19;448(7151):353-7
references.pmid: 17603472
references.citation: Nat Genet. 2008 Jun;40(6):703-6
references.pmid: 18438407
references.citation: Nat Genet. 2003 Feb;33(2):177-82
references.pmid: 12524541
references.citation: Am J Hum Genet. 1997 Dec;61(6):1335-41
references.pmid: 9399900
references.citation: Ann Hum Genet. 2003 Jul;67(Pt 4):281-97
references.pmid: 12914564
references.citation: J Med Genet. 2003 Dec;40(12):925-32
references.pmid: 14684692
references.citation: Am J Med Genet B Neuropsychiatr Genet. 2009 Mar 5;150B(2):191-201
references.pmid: 18444255
references.citation: Diabetes Care. 2006 Aug;29(8):1866-71
references.pmid: 16873794
references.citation: Nat Genet. 2007 May;39(5):650-4
references.pmid: 17417636
references.citation: Nat Genet. 2007 Aug;39(8):977-83
references.pmid: 17603485
references.citation: Hum Mol Genet. 2001 Jul 15;10(15):1611-7
references.pmid: 11468279
references.citation: Diabetes. 2007 Oct;56(10):2643-8
references.pmid: 17646211
references.citation: Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2736-42
references.pmid: 17885212
references.citation: PLoS Genet. 2006 May;2(5):e69
references.pmid: 16699592
references.citation: Nat Genet. 2007 Dec;39(12):1443-52
references.pmid: 17952075
references.citation: Nat Genet. 2008 Mar;40(3):281-3
references.pmid: 18264098
references.citation: Nat Genet. 2006 Jun;38(6):663-7
references.pmid: 16715096
references.citation: Science. 2007 Sep 7;317(5843):1397-400
references.pmid: 17690259
references.citation: Science. 2007 Feb 9;315(5813):848-53
references.pmid: 17289997
references.citation: Science. 2004 Apr 9;304(5668):300-4
references.pmid: 15073379
references.citation: Science. 2007 Jun 8;316(5830):1491-3
references.pmid: 17478679
references.citation: Nat Genet. 2006 Mar;38(3):320-3
references.pmid: 16415884
references.citation: Hum Mol Genet. 2005 Sep 1;14(17):2595-605
references.pmid: 16076849
references.citation: Eur J Hum Genet. 2007 Sep;15(9):911-6
references.pmid: 17568393
references.citation: Nat Genet. 2005 Dec;37(12):1320-2
references.pmid: 16258542
references.citation: Science. 2004 Aug 6;305(5685):869-72
references.pmid: 15297675
references.citation: Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14747-52
references.pmid: 17804789
references.citation: Nat Genet. 2007 Jul;39(7):865-9
references.pmid: 17529974
references.citation: Nat Genet. 2008 Mar;40(3):340-5
references.pmid: 18246066
references.citation: Nature. 2007 Jun 7;447(7145):661-78
references.pmid: 17554300
references.citation: Genetics. 2006 Oct;174(2):959-84
references.pmid: 16888333
references.citation: Am J Hum Genet. 1995 May;56(5):1088-95
references.pmid: 7726163
references.citation: Nat Genet. 2006 May;38(5):556-60
references.pmid: 16582909
references.citation: Nat Genet. 1999 Jun;22(2):139-44
references.pmid: 10369254
references.citation: Nature. 2008 Apr 3;452(7187):638-642
references.pmid: 18385739
references.citation: Am J Med Genet B Neuropsychiatr Genet. 2004 Jul 1;128B(1):65-70
references.pmid: 15211634
references.citation: Clin Genet. 2002 Apr;61(4):233-47
references.pmid: 12030885
references.citation: Nature. 2001 Feb 15;409(6822):860-921
references.pmid: 11237011
references.citation: Mol Psychiatry. 2003 Jul;8(7):695-705, 643
references.pmid: 12874606
references.citation: Nat Genet. 2001 Oct;29(2):233-7
references.pmid: 11586306
references.citation: Hum Genet. 2003 Dec;114(1):1-10
references.pmid: 13680359
references.citation: Mol Psychiatry. 2002;7(7):689-94
references.pmid: 12192612
references.citation: Diabetes. 2004 May;53(5):1181-6
references.pmid: 15111484
references.citation: Nat Genet. 2008 May;40(5):609-15
references.pmid: 18391951
references.citation: Am J Hum Genet. 2007 Sep;81(3):615-25
references.pmid: 17701907
references.citation: N Engl J Med. 2008 May 29;358(22):2355-65
references.pmid: 18445777
references.citation: Hum Mol Genet. 2006 Nov 1;15(21):3146-53
references.pmid: 16984960
references.citation: Hum Mol Genet. 2003 Dec 1;12(23):3151-9
references.pmid: 14532331
references.citation: Am J Hum Genet. 2005 Feb;76(2):237-48
references.pmid: 15614721
references.citation: Nat Genet. 2004 Mar;36(3):233-9
references.pmid: 14770184
references.citation: Am J Hum Genet. 2007 Jun;80(6):1103-14
references.pmid: 17503328
references.citation: Nat Genet. 2007 Jun;39(6):770-5
references.pmid: 17460697
references.citation: Am J Med Genet A. 2008 Apr 15;146A(8):1072-87
references.pmid: 18348259
references.citation: Trends Genet. 2003 Mar;19(3):135-40
references.pmid: 12615007