title: Ovarian and multiple lymph nodes recurrence of acute lymphoblastic leukemia: a case report and review of literature.
abstract: Ovarian involvement of acute lymphoblastic leukemia (ALL) without relapse in the bone marrow or other extramedullary site is rare. We report a case of ovarian relapse in a 13-year-old girl who was diagnosed with ALL at the age of 11. A complete remission was induced with the Children Cancer Group 1882 protocol for high-risk-groups. After maintenance chemotherapy, the patient remained in relatively good health for the next 4 months. The patient presented with intermittent colicky right lower quadrant pain of 1-day duration. The pelvic ultrasound (US) showed a lobulated mixed echogenic mass in the right ovary, and an exploratory laparotomy was performed. Although uncommon, ovarian recurrence after treatment for ALL should be considered in patients with suggestive symptoms. Regular pelvic US is easy to perform and has no side effects and can help detect ovarian tumors early in ALL survivors.
authors.affiliation: Department of Obstetrics and Gynecology, Chonnam National University Medical School, 8 Hakdong, Donggu, Gwangju, 501-190, Korea.
authors.forename: Jong Woon
authors.initials: JW
authors.lastname: Kim
authors.forename: Moon Kyoung
authors.initials: MK
authors.lastname: Cho
authors.forename: Cheol Hong
authors.initials: CH
authors.lastname: Kim
authors.forename: Woo Dae
authors.initials: WD
authors.lastname: Kang
authors.forename: Hoon
authors.initials: H
authors.lastname: Kook
authors.forename: Yoon Ha
authors.initials: YH
authors.lastname: Kim
authors.forename: Ho Sun
authors.initials: HS
authors.lastname: Choi
authors.forename: Seok Mo
authors.initials: SM
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D012008:Recurrence
references.citation: Am J Hematol. 1989 Jan;30(1):42-3
references.pmid: 2910079
references.citation: J Clin Pathol. 1980 Aug;33(8):722-9
references.pmid: 6933154
references.citation: Lancet. 1973 Mar 10;1(7802):534-8
references.pmid: 4119962
references.citation: Am J Hematol. 1989 Oct;32(2):155
references.pmid: 2757013
references.citation: Pediatr Pol. 1985 Jul;60(7):543-5
references.pmid: 3867850
references.citation: N Engl J Med. 1982 Apr 22;306(16):993
references.pmid: 6950225
references.citation: Pediatr Hematol Oncol. 2003 Jul-Aug;20(5):417-20
references.pmid: 12775541
references.citation: Lille Med. 1978 May;23(3):151-7
references.pmid: 274606
references.citation: J Pediatr Surg. 1991 Jan;26(1):70-4
references.pmid: 2005530
references.citation: Br J Obstet Gynaecol. 1979 Jul;86(7):578-80
references.pmid: 289410
references.citation: Cancer. 1982 Aug 1;50(3):587-93
references.pmid: 7093900
references.citation: Acta Haematol. 1983;69(4):278-80
references.pmid: 6402883
references.citation: Am J Hematol. 2005 Sep;80(1):75-6
references.pmid: 16138346
references.citation: Leuk Res. 2005 Sep;29(9):1089-94
references.pmid: 16038737
references.citation: Oncology. 1978;35(2):87-96
references.pmid: 274679
references.citation: AMB Rev Assoc Med Bras. 1979 Sep;25(9):323-5
references.pmid: 317372
references.citation: J Pediatr. 1982 Mar;100(3):422-4
references.pmid: 6950077
references.citation: Cancer. 1986 Nov 15;58(10):2338-42
references.pmid: 3530429
references.citation: Acta Haematol. 1994;92(1):56
references.pmid: 7985489
references.citation: Cancer. 1981 Jul 15;48(2):377-9
references.pmid: 6940651
references.citation: Postgrad Med J. 1982 Nov;58(685):724-5
references.pmid: 6963410
references.citation: J Clin Ultrasound. 1986 Mar-Apr;14(3):191-5
references.pmid: 3084568
references.citation: N Engl J Med. 1981 Nov 5;305(19):1135-46
references.pmid: 6945478
references.citation: AJR Am J Roentgenol. 1981 Aug;137(2):399-401
references.pmid: 6789652