title: Single nucleotide polymorphisms associated with coronary heart disease predict incident ischemic stroke in the atherosclerosis risk in communities study.
abstract: Ischemic stroke and coronary heart disease (CHD) may share genetic factors contributing to a common etiology. This study investigates whether 51 single nucleotide polymorphisms (SNPs) associated with CHD in multiple antecedent studies are associated with incident ischemic stroke in the Atherosclerosis Risk in Communities (ARIC) study. From the multiethnic ARIC cohort of 14,215 individuals, 495 validated ischemic strokes were identified. Cox proportional hazards models, adjusted for age and gender, identified three SNPs in Whites and two SNPs in Blacks associated with incident stroke (p <or= 0.05). The rs11628722 polymorphism in SERPINA9 was associated with incident stroke in Whites and Blacks, even after taking into account traditional risk factors. The idea that ischemic stroke and CHD may share some common genetic factors, such as variation in SERPINA9, should be investigated in other studies.
authors.affiliation: Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Alanna.C.Morrison@uth.tmc.edu
authors.forename: Alanna C
authors.initials: AC
authors.lastname: Morrison
authors.forename: Lance A
authors.initials: LA
authors.lastname: Bare
authors.forename: May M
authors.initials: MM
authors.lastname: Luke
authors.forename: James S
authors.initials: JS
authors.lastname: Pankow
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Mosley
authors.forename: James J
authors.initials: JJ
authors.lastname: Devlin
authors.forename: James T
authors.initials: JT
authors.lastname: Willerson
authors.forename: Eric
authors.initials: E
authors.lastname: Boerwinkle
mesh_terms: D044383:Black People / Q000235:genetics / Q000706:statistics & numerical data; D002545:Brain Ischemia / Q000453:epidemiology / Q000235:genetics; D003327:Coronary Disease / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D015994:Incidence; D002537:Intracranial Arteriosclerosis / Q000453:epidemiology / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology / Q000235:genetics; D009363:Neoplasm Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D012307:Risk Factors; D015843:Serpins / Q000235:genetics*; D020521:Stroke / Q000453:epidemiology* / Q000235:genetics*; D044465:White People / Q000235:genetics / Q000706:statistics & numerical data
chemical_list: D009363:Neoplasm Proteins; C476825:SERPINA9 protein, human; D015843:Serpins
references.citation: Circulation. 1998 May 12;97(18):1837-47
references.pmid: 9603539
references.citation: Am J Epidemiol. 1989 Apr;129(4):687-702
references.pmid: 2646917
references.citation: Stroke. 1999 Apr;30(4):736-43
references.pmid: 10187871
references.citation: N Engl J Med. 2000 Oct 19;343(16):1148-55
references.pmid: 11036120
references.citation: Stroke. 1991 Mar;22(3):312-8
references.pmid: 2003301
references.citation: J Thromb Thrombolysis. 2004 Feb;17(1):51-61
references.pmid: 15277788
references.citation: Neurochem Res. 2006 Aug;31(8):1035-44
references.pmid: 16933151
references.citation: Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2763-8
references.pmid: 17008591
references.citation: Nat Rev Genet. 2006 Oct;7(10):812-20
references.pmid: 16983377
references.citation: Am J Epidemiol. 2007 Jul 1;166(1):28-35
references.pmid: 17443022
references.citation: Genet Med. 2007 Oct;9(10):682-9
references.pmid: 18073581
references.citation: Genome Biol. 2006;7(5):216
references.pmid: 16737556
references.citation: Diabetes Care. 1999 Jul;22(7):1077-83
references.pmid: 10388971
references.citation: Circulation. 2007 Feb 6;115(5):e69-171
references.pmid: 17194875
references.citation: J Am Coll Cardiol. 2008 Jan 29;51(4):435-43
references.pmid: 18222353
references.citation: N Engl J Med. 1996 Oct 3;335(14):1001-9
references.pmid: 8801446
references.citation: Crit Rev Biomed Eng. 1999;27(1-2):75-148
references.pmid: 10638850
references.citation: Cytometry. 2000 Feb 1;39(2):131-40
references.pmid: 10679731