title: Myelodysplasia and Good syndrome. A case report.
abstract: Good syndrome (GS) is a rare adult-onset immunodeficiency disease characterised by hypogammaglobulinaemia and thymoma. Here we describe a 72-year-old male patient who was diagnosed with GS when he was 62, after a two-year history of recurrent respiratory infections. A chest CT scan showed a mediastinal mass which was surgically removed; its histology revealed a thymoma. The patient was hypogammaglobulinaemic and his clinical condition dramatically improved after starting an appropriate dosage of IVIG. Two years ago he developed a normochromic normocytic anaemia requiring several transfusions. A bone marrow biopsy revealed a myelodysplastic syndrome. The patient started cyclosporine and the anaemia gradually improved, achieving transfusion independence.
authors.affiliation: U.O. di Medicina III, Policlinico Le Scotte, Viale Bracci 16, Siena, Italy. cd28apo@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: Di Renzo
authors.forename: A L
authors.initials: AL
authors.lastname: Pasqui
authors.forename: L
authors.initials: L
authors.lastname: Voltolini
authors.forename: G
authors.initials: G
authors.lastname: Gotti
authors.forename: G
authors.initials: G
authors.lastname: Pompella
authors.forename: A
authors.initials: A
authors.lastname: Auteri
mesh_terms: D000368:Aged; D016572:Cyclosporine / Q000627:therapeutic use; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications / Q000175:diagnosis*; D008297:Male; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D016572:Cyclosporine
references.citation: N Z Med J. 2004 Jan 30;117(1188):U750
references.pmid: 14999309
references.citation: Leuk Res. 2001 Dec;25(12):1075-83
references.pmid: 11684279
references.citation: Medicine (Baltimore). 2001 Mar;80(2):123-33
references.pmid: 11307588
references.citation: Ann N Y Acad Sci. 2005 Jun;1051:658-65
references.pmid: 16127006
references.citation: Br J Haematol. 2002 Oct;119(1):97-105
references.pmid: 12358908
references.citation: Blood Rev. 2005 Nov;19(6):301-19
references.pmid: 15885860
references.citation: Blood. 2003 Apr 15;101(8):3106-8
references.pmid: 12515721
references.citation: Ann Allergy Asthma Immunol. 2007 Feb;98(2):185-90
references.pmid: 17304889
references.citation: Ann Hematol. 2005 Sep;84(9):565-8
references.pmid: 15809884