4-Azatricyclo[5.2.2.02,6]undecane-3,5,8-triones as potential pharmacological agents.
A series of twenty six arylpiperazine and aminoalkanol derivatives of 4-azatricyclo[5.2.2.0(2,6)]undecane-3,5,8-trione have been prepared. The synthesized compounds were evaluated for their cytotoxicity and anti-HIV-1 activity in MT-4 cells.
Kossakowski
Jerzy
J
Department of Medical Chemistry, The Medical University of Warsaw, 3 Oczki Street, 02-007 Warsaw, Poland.
Bielenica
Anna
A
Mirosław
Barbara
B
Kozioł
Anna E
AE
Dybała
Izabela
I
Struga
Marta
M
D000438:Alcohols / Q000737:chemistry / Q000494:pharmacology*; D000473:Alkanes / Q000737:chemistry / Q000494:pharmacology; D019380:Anti-HIV Agents / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D010879:Piperazines / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000438:Alcohols; D000473:Alkanes; D019380:Anti-HIV Agents; D010879:Piperazines; C022884:undecane
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