Sweet syndrome as a manifestation of azathioprine hypersensitivity.
Sweet syndrome is a reactive, sterile, pustular dermatosis that occurs in association with infection, malignancy, or connective tissue disease or in response to the use of certain medications. Sweet syndrome secondary to azathioprine therapy is rarely reported. We describe 3 patients, 2 with inflammatory bowel disease and 1 with myasthenia gravis, who developed febrile pustulosis consistent with Sweet syndrome 1 to 2 weeks after treatment with azathioprine. Antibiotic therapy failed in all patients, but Sweet syndrome resolved with drug withdrawal and prednisone therapy. Because azathioprine is widely used, clinicians should be aware of this adverse reaction.
El-Azhary
Rokea A
RA
Department of Dermatology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA. elazhary.rokea2@mayo.edu
Brunner
Kelly L
KL
Gibson
Lawrence E
LE
D000328:Adult; D000368:Aged; D001379:Azathioprine / Q000008:administration & dosage / Q000009:adverse effects*; D003093:Colitis, Ulcerative / Q000188:drug therapy; D003424:Crohn Disease / Q000188:drug therapy; D004342:Drug Hypersensitivity / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy; D008297:Male; D009157:Myasthenia Gravis / Q000188:drug therapy; D011241:Prednisone / Q000008:administration & dosage; D012075:Remission, Spontaneous; D016463:Sweet Syndrome / Q000139:chemically induced* / Q000188:drug therapy
D007166:Immunosuppressive Agents; D001379:Azathioprine; D011241:Prednisone