Recovery of long-term anterograde amnesia, but not retrograde amnesia, after initiation of an anti-epileptic drug in a case of transient epileptic amnesia.
Transient epileptic amnesia (TEA) is characterised by recurrent brief episodes of amnesia and atypical amnesic symptoms, known as long-term anterograde amnesia and dense retrograde amnesia. It has been proposed that an antiepileptic drug (AED) can prevent not only epileptiform activity, but also accelerated forgetting. However, there have been no reports regarding the effects of such drugs on retrograde amnesia. We found that an AED prevented accelerated forgetting, but not dense retrograde amnesia, suggesting that accelerated forgetting in TEA was treatable, but retrograde amnesia was an irreversible process.
Midorikawa
Akira
A
Department of Psychology, Chuo University, Hachioji, Tokyo, Japan. green@tamacc.chuo-u.ac.jp
Kawamura
Mitsuru
M
D020324:Amnesia, Anterograde / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D000648:Amnesia, Retrograde / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D020236:Amnesia, Transient Global / Q000150:complications / Q000188:drug therapy*; D000927:Anticonvulsants / Q000627:therapeutic use*; D002220:Carbamazepine / Q000627:therapeutic use*; D004827:Epilepsy / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000187:drug effects*; D008875:Middle Aged; D009483:Neuropsychological Tests; D020534:Parahippocampal Gyrus / Q000503:physiopathology; D020127:Recovery of Function; D016896:Treatment Outcome
D000927:Anticonvulsants; D002220:Carbamazepine