title: Synthesis and biological evaluation of alkoxycoumarins as novel nematicidal constituents.
abstract: We synthesized all of the monomethoxycoumarins, 5-alkoxycoumarins and their derivatives, and investigated their nematicidal activity against the phytopathogenic nematode, Bursaphelenchus xylophilus. Among the compounds, 5-ethoxycoumarin showed the highest nematicidal activity. Furthermore, 5-ethoxycoumarin was comparatively harmless against both the brine shrimps, Artemia salina, and the Japanese killifish, Oryzias latipes.
authors.affiliation: Laboratory of Applied Natural Products Chemistry, The Graduate School of Natural Science and Technology, Okayama University, 1-1-1 Tsushimanaka, Okayama, Okayama 700-8530, Japan. ktakaishi@riken.jp
authors.forename: Kazuto
authors.initials: K
authors.lastname: Takaishi
authors.forename: Minoru
authors.initials: M
authors.lastname: Izumi
authors.forename: Naomichi
authors.initials: N
authors.lastname: Baba
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Kawazu
authors.forename: Shuhei
authors.initials: S
authors.lastname: Nakajima
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001156:Artemia; D001681:Biological Assay; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D006868:Hydrolysis; D008956:Models, Chemical; D009348:Nematoda; D009990:Oryzias; D013329:Structure-Activity Relationship
chemical_list: D000969:Antinematodal Agents; D003374:Coumarins; C030123:coumarin