title: Clinical significance of insulin-like growth factor-1 receptor expression in stage I non-small-cell lung cancer: immunohistochemical analysis.
abstract: OBJECTIVE
  The insulin-like growth factor (IGF) system has been implicated in tumor growth, invasion, and metastasis. However, reports on the IGF-1 receptor (IGF-1R) based on radioimmunoassays are conflicting, and its prognostic implications in non-small-cell lung cancer (NSCLC) are still controversial.
  
  
  METHODS
  Seventy-one paraffin-embedded tissue sections from stage I NSCLC patients were stained using a mouse monoclonal antibody against human IGF-1R.
  
  
  RESULTS
  The intensity and frequency of IGF-1R expression on the membrane and cytoplasm of cancer cells was evaluated and scored using a semiquantitative system. IGF-1R expression was detected in nine of 71 (12.7%) cases. No significant relationship was found between clinical/histopathological parameters and IGF-1R expression. None of the patients whose tumor expressed IGF-1R had experienced distant metastasis or cancer-related death, although the difference did not reach statistical significance.
  
  
  CONCLUSIONS
  We conclude that IGF-1R expression may not be a major prognostic factor for stage I NSCLC.
authors.affiliation: Department of Internal Medicine 1, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea.
authors.forename: Chang Youl
authors.initials: CY
authors.lastname: Lee
authors.forename: Jeong Hee
authors.initials: JH
authors.lastname: Jeon
authors.forename: Hyung Jung
authors.initials: HJ
authors.lastname: Kim
authors.forename: Dong Hwan
authors.initials: DH
authors.lastname: Shin
authors.forename: Tae Woong
authors.initials: TW
authors.lastname: Roh
authors.forename: Chul Min
authors.initials: CM
authors.lastname: Ahn
authors.forename: Yoon Soo
authors.initials: YS
authors.lastname: Chang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D002289:Carcinoma, Non-Small-Cell Lung / Q000276:immunology* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D017526:Receptor, IGF Type 1 / Q000096:biosynthesis*
chemical_list: D007334:Insulin-Like Growth Factor I; D017526:Receptor, IGF Type 1
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