title: Composition and applications of Aloe vera leaf gel.
abstract: Many of the health benefits associated with Aloe vera have been attributed to the polysaccharides contained in the gel of the leaves. These biological activities include promotion of wound healing, antifungal activity, hypoglycemic or antidiabetic effects antiinflammatory, anticancer, immunomodulatory and gastroprotective properties. While the known biological activities of A. vera will be briefly discussed, it is the aim of this review to further highlight recently discovered effects and applications of the leaf gel. These effects include the potential of whole leaf or inner fillet gel liquid preparations of A. vera to enhance the intestinal absorption and bioavailability of co-administered compounds as well as enhancement of skin permeation. In addition, important pharmaceutical applications such as the use of the dried A. vera gel powder as an excipient in sustained release pharmaceutical dosage forms will be outlined.
authors.affiliation: Department of Pharmaceutical Sciences, Tshwane University of Technology, Private Bag X680, Pretoria, 0001, South Africa. hammanjh@tut.ac.za
authors.forename: Josias H
authors.initials: JH
authors.lastname: Hamman
mesh_terms: D000504:Aloe / Q000737:chemistry*; D001682:Biological Availability; D004337:Drug Carriers / Q000737:chemistry; D004643:Emollients; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D010539:Permeability; D011134:Polysaccharides / Q000493:pharmacokinetics / Q000627:therapeutic use*; D012867:Skin / Q000378:metabolism
chemical_list: D004337:Drug Carriers; D004643:Emollients; D011134:Polysaccharides
references.citation: J Ethnopharmacol. 2004 Jul;93(1):33-7
references.pmid: 15182901
references.citation: Phytomedicine. 2005 Nov;12(10):760-5
references.pmid: 16323295
references.citation: Eur J Pharm Biopharm. 2001 Sep;52(2):103-12
references.pmid: 11522474
references.citation: Int J Toxicol. 2007;26 Suppl 2:1-50
references.pmid: 17613130
references.citation: Appl Microbiol Biotechnol. 2008 May;79(2):165-78
references.pmid: 18385995
references.citation: Immunopharmacology. 1996 Nov;35(2):119-28
references.pmid: 8956975
references.citation: Farmaco. 2005 Nov-Dec;60(11-12):874-83
references.pmid: 16243320
references.citation: Int J Pharm. 2001 Aug 14;224(1-2):19-38
references.pmid: 11472812
references.citation: Skin Res Technol. 2006 Nov;12(4):241-6
references.pmid: 17026654
references.citation: J Ethnopharmacol. 2007 May 22;111(3):560-6
references.pmid: 17291700
references.citation: Int Immunopharmacol. 2005 Feb;5(2):271-9
references.pmid: 15652758
references.citation: Clin Hemorheol Microcirc. 2006;35(3):359-66
references.pmid: 16899957
references.citation: Biochem Pharmacol. 2004 Aug 1;68(3):549-61
references.pmid: 15242821
references.citation: Int Immunopharmacol. 2004 Dec 20;4(14):1727-37
references.pmid: 15531289
references.citation: Int J Pharm. 2007 Mar 21;333(1-2):10-6
references.pmid: 17088033
references.citation: Clin Exp Pharmacol Physiol. 2006 Mar;33(3):232-7
references.pmid: 16487267
references.citation: J Ethnopharmacol. 1999 Dec 15;68(1-3):3-37
references.pmid: 10624859
references.citation: Int Immunopharmacol. 2004 Dec 20;4(14):1757-73
references.pmid: 15531292
references.citation: Int J Pharm. 1999 Jul 5;184(1):1-6
references.pmid: 10425346
references.citation: J Agric Food Chem. 2001 Feb;49(2):1030-4
references.pmid: 11262067
references.citation: Carbohydr Res. 2005 May 2;340(6):1131-42
references.pmid: 15797128
references.citation: Carbohydr Res. 2006 Feb 27;341(3):355-64
references.pmid: 16343466
references.citation: J Ethnopharmacol. 2004 Feb;90(2-3):239-47
references.pmid: 15013187
references.citation: Methods. 2007 Aug;42(4):315-20
references.pmid: 17560318
references.citation: J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2006 Apr;24(1):103-54
references.pmid: 16690538
references.citation: Pharm Sci Technol Today. 2000 Dec 1;3(12):426-430
references.pmid: 11116202
references.citation: Curr Drug Deliv. 2004 Jan;1(1):81-92
references.pmid: 16305373
references.citation: Drug Deliv. 2005 Jul-Aug;12(4):201-6
references.pmid: 16036714
references.citation: Int Immunopharmacol. 2004 Dec 20;4(14):1745-55
references.pmid: 15531291
references.citation: Br J Dermatol. 2001 Oct;145(4):535-45
references.pmid: 11703278
references.citation: J Ethnopharmacol. 1996 Dec;55(1):69-75
references.pmid: 9121170
references.citation: J Photochem Photobiol B. 2001 Oct;63(1-3):132-40
references.pmid: 11684460
references.citation: Crit Rev Ther Drug Carrier Syst. 1990;7(1):1-33
references.pmid: 2257635
references.citation: J Control Release. 2007 May 14;119(1):5-24
references.pmid: 17382422
references.citation: Aliment Pharmacol Ther. 2004 Mar 1;19(5):521-7
references.pmid: 14987320
references.citation: Crit Rev Food Sci Nutr. 2004;44(2):91-6
references.pmid: 15116756