title: A single dose of anti-D immunoglobulin raises platelet count as efficiently as intravenous immunoglobulin in newly diagnosed immune thrombocytopenic purpura in Korean children.
abstract: OBJECTIVE
  The aim of this study is to compare the efficacy and safety of a single dose of anti-D immunoglobulin (anti-D) at 50 mug/kg to intravenous immunoglobulin (IVIG) in Korean children with acute immune thrombocytopenic purpura (ITP).
  
  
  METHODS
  We performed this study prospectively by randomly administering 2 consecutive doses of IVIG at a dose of 1.0 g/kg/dor a single dose of anti-D at 50 microg/kg to children upon initial diagnosis of acute ITP. The platelet count and adverse events, including hemoglobin concentration, were then serially evaluated, and the responses were compared.
  
  
  RESULTS
  The likelihood of having a platelet count greater than 20x10/mm after 3 days of treatment in the IVIG and anti-D group was 93% and 92%, respectively. In addition, hemoglobin concentration in the anti-D group had declined more than that of the IVIG group (1.49 g/dL vs. 0.80 g/dL, P=0.014) 3 days after treatment. Fever, chills, and headache occurred less frequently in the anti-D group than the IVIG group, however, this difference was not statistically significant (25% vs. 45%, P=0.494).
  
  
  CONCLUSIONS
  A single dose of 50 microg/kg of anti-D raised platelet count as efficiently as IVIG in newly diagnosed cases of ITP in Korean children. Although 50 microg/kg of anti-D had a greater effect on the hemoglobin concentration than IVIG, the adverse effects were found to be acceptable, and no serious events were observed.
authors.affiliation: Department of Pediatrics, Gil Medical Center, Gachon Medical School, Gachon University of Medicine and Science, Incheon, Korea.
authors.forename: Dong Woo
authors.initials: DW
authors.lastname: Son
authors.forename: In-sang
authors.initials: IS
authors.lastname: Jeon
authors.forename: Sung Wan
authors.initials: SW
authors.lastname: Yang
authors.forename: Sang Hee
authors.initials: SH
authors.lastname: Cho
mesh_terms: D001792:Blood Platelets / Q000187:drug effects; D002675:Child, Preschool; D005260:Female; D006454:Hemoglobins / Q000187:drug effects; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007723:Korea; D008297:Male; D010976:Platelet Count; D011696:Purpura, Thrombocytopenic / Q000188:drug therapy*; D018029:Rho(D) Immune Globulin / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D006454:Hemoglobins; D016756:Immunoglobulins, Intravenous; D018029:Rho(D) Immune Globulin