title: Common variants of FUT2 are associated with plasma vitamin B12 levels.
abstract: We identified a strong association (P = 5.36 x 10(-17)) between rs492602 in FUT2 and plasma vitamin B(12) levels in a genome-wide scan (n = 1,658) and an independent replication sample (n = 1,059) from the Nurses' Health Study. Women homozygous for the rs492602[G] allele had higher B(12) levels. This allele is in strong linkage disequilibrium with the FUT2 nonsecretor variant encoding W143X, suggesting a plausible mechanism for altered B(12) absorption and plasma levels.
authors.affiliation: Department of Epidemiology, Harvard School of Public Health, Program in Molecular and Genetic Epidemiology, Boston, Massachusetts 02115, USA.
authors.forename: Aditi
authors.initials: A
authors.lastname: Hazra
authors.forename: Peter
authors.initials: P
authors.lastname: Kraft
authors.forename: Jacob
authors.initials: J
authors.lastname: Selhub
authors.forename: Edward L
authors.initials: EL
authors.lastname: Giovannucci
authors.forename: Gilles
authors.initials: G
authors.lastname: Thomas
authors.forename: Robert N
authors.initials: RN
authors.lastname: Hoover
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Chanock
authors.forename: David J
authors.initials: DJ
authors.lastname: Hunter
mesh_terms: D000328:Adult; D005260:Female; D005647:Fucosyltransferases / Q000235:genetics*; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D015894:Genome, Human; D006720:Homozygote; D006801:Humans; D008875:Middle Aged; D009726:Nurses; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D014805:Vitamin B 12 / Q000097:blood* / Q000235:genetics; D000097631:Galactoside 2-alpha-L-fucosyltransferase
chemical_list: D005647:Fucosyltransferases; D014805:Vitamin B 12; D000097631:Galactoside 2-alpha-L-fucosyltransferase
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