title: Dental and periodontal history of oncologic patients on parenteral bisphosphonates with or without osteonecrosis of the jaws: a pilot study.
abstract: OBJECTIVE
  We tested the hypothesis that patients on bisphosphonates with ONJ might have a poorer dental and periodontal history than non-ONJ patients. Our aim was to retrospectively compare medical and oral history of patients on bisphosphonates with and without ONJ.
  
  
  METHODS
  A total of 39 oncologic patients on bisphosphonates were interviewed, examined, and had a panoramic radiograph taken. DMFT values and residual bone levels were calculated and compared for ONJ and non-ONJ patients.
  
  
  RESULTS
  Twenty of 39 patients had ONJ. No statistical differences in caries or residual bone level as well as dental extractions were detected, although twice as many patients with ONJ underwent dental extractions. ONJ patients had received statistically more administrations of bisphosphonates compared to non-ONJ patients.
  
  
  CONCLUSIONS
  A long history of bisphosphonate administration might represent a risk for ONJ onset.
authors.affiliation: Department of Medicine, University of Milan, Italy. daniela.carmagnola@unimi.it
authors.forename: Daniela
authors.initials: D
authors.lastname: Carmagnola
authors.forename: Silvio
authors.initials: S
authors.lastname: Celestino
authors.forename: Silvio
authors.initials: S
authors.lastname: Abati
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016301:Alveolar Bone Loss / Q000473:pathology; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004245:DMF Index; D004164:Diphosphonates / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000009:adverse effects*; D007571:Jaw Diseases / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy; D010020:Osteonecrosis / Q000139:chemically induced*; D010512:Periodontal Index; D010865:Pilot Projects; D012189:Retrospective Studies; D012307:Risk Factors; D013282:Stomatitis, Denture / Q000150:complications; D014081:Tooth Extraction / Q000009:adverse effects; D000077211:Zoledronic Acid
chemical_list: D000970:Antineoplastic Agents; D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid