title: Patterns of amino acid evolution in the Drosophila ananassae chimeric gene, siren, parallel those of other Adh-derived chimeras.
abstract: siren1 and siren2 are novel alcohol dehydrogenase (Adh)-derived chimeric genes in the Drosophila bipectinata complex. D. ananassae, however, harbors a single homolog of these genes. Like other Adh-derived chimeric genes, siren evolved adaptively shortly after it was formed. These changes likely shifted the catalytic activity of siren.
authors.affiliation: Department of Biology and Carolina Center for the Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599-3280, USA.
authors.forename: Hung-Jui
authors.initials: HJ
authors.lastname: Shih
authors.forename: Corbin D
authors.initials: CD
authors.lastname: Jones
mesh_terms: D000426:Alcohol Dehydrogenase / Q000235:genetics*; D000596:Amino Acids / Q000235:genetics*; D000818:Animals; D004330:Drosophila / Q000201:enzymology / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics*; D019143:Evolution, Molecular; D050939:Gene Fusion; D017344:Genes, Insect; D008969:Molecular Sequence Data
chemical_list: D000596:Amino Acids; D029721:Drosophila Proteins; C073796:ADH protein, Drosophila; D000426:Alcohol Dehydrogenase
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