title: Modeling distraction osteogenesis: analysis of the distraction rate.
abstract: Distraction osteogenesis is a useful technique aimed at inducing bone formation in widespread clinical applications. One of the most important factors that conditions the success of bone regeneration is the distraction rate. Since the mechanical environment around the osteotomy site is one of the main factors that affects both quantity and quality of the regenerated bone, we have focused on analyzing how the distraction rate influences on the mechanical conditions and tissue regeneration. Therefore, the aim of the present work is to explore the potential of a mathematical algorithm to simulate clinically observed distraction rate related phenomena that occur during distraction osteogenesis. Improvements have been performed on a previous model (Gómez-Benito et al. in J Theor Biol 235:105-119, 2005) in order to take into account the load history. The results obtained concur with experimental findings: a slow distraction rate results in premature bony union, whereas a fast rate results in a fibrous union. Tension forces in the interfragmentary gap tissue have also been estimated and successfully compared with experimental measurements.
authors.affiliation: Department of Mechanical Engineering, University of Seville, 41092, Seville, Spain. erreina@us.es
authors.forename: E
authors.initials: E
authors.lastname: Reina-Romo
authors.forename: M J
authors.initials: MJ
authors.lastname: Gómez-Benito
authors.forename: J M
authors.initials: JM
authors.lastname: García-Aznar
authors.forename: J
authors.initials: J
authors.lastname: Domínguez
authors.forename: M
authors.initials: M
authors.lastname: Doblaré
mesh_terms: D000465:Algorithms; D000818:Animals; D001696:Biomechanical Phenomena; D001861:Bone Regeneration; D004867:Equipment Design; D008954:Models, Biological; D015233:Models, Statistical; D008962:Models, Theoretical; D010012:Osteogenesis; D019857:Osteogenesis, Distraction / Q000379:methods*; D011312:Pressure; D012756:Sheep; D012984:Software