[A case of pulmonary pleomorphic carcinoma with epidermal growth factor receptor (EGFR) mutation].
A 70-year-old woman with cough was diagnosed with pulmonary adenocarcinoma by bronchoscopic transbronchial biopsy. She was diagnosed cT2N0M0, stage IB clinically, and the tumor was surgically resected. Postoperative pathology was confirmed to be pleomorphic carcinoma of pT2N2M0, stage III A. She received 6 courses of adjuvant chemotherapy consisting of cisplatin and docetaxel. Five months later, new pulmonary and bone metastases were detected. Gefitinib was started, and she has shown stable disease for 7 months. Epidermal growth factor receptor (EGFR) mutation was observed in her tumor specimens.
Watanabe
Kana
K
Dept. of Pulmonary Medicine, Fukushima Medical University.
Ishida
Takashi
T
Fukuhara
Atsuro
A
Sekine
Satoko
S
Uekita
Kumi
K
Sugawara
Aya
A
Tachihara
Motoko
M
Kanazawa
Kenya
K
Saito
Junpei
J
Tanino
Yoshinori
Y
Munakata
Mitsuru
M
D000230:Adenocarcinoma / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D009154:Mutation; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed
D000970:Antineoplastic Agents; D066246:ErbB Receptors