title: Experiences with recombinant FVIIa in the emergency treatment of patients with autoimmune thrombocytopenia: a review of the literature.
abstract: Patients with severe and refractory autoimmune thrombocytopenia (ITP) have significant morbidity and mortality rates. Currently, high-dose methylprednisolone and/or high-dose IVIgG are recommended for the emergency treatment of such patients with uncontrolled bleeding. However, some patients do not immediately respond to these therapeutic regimes and may require additional treatment. Recombinant activated FVIIa (rFVIIa) is a prothrombotic agent that appears to be useful in the treatment of patients with life-threatening bleeding. It has also been used in the treatment of several patients with thrombocytopenia. We administered rFVIIa into a patient with refractory ITP and performed a systemic review of all published reports to assess the available evidence on the efficacy and safety of this drug in patients with ITP. The results indicate that rFVIIa may help in the emergency treatment of patients with ITP who do not respond to other therapies.
authors.affiliation: Institut für Transfusionsmedizin, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany. abdulgabar.salama@charite.de
authors.forename: A
authors.initials: A
authors.lastname: Salama
authors.forename: M
authors.initials: M
authors.lastname: Rieke
authors.forename: H
authors.initials: H
authors.lastname: Kiesewetter
authors.forename: M
authors.initials: M
authors.lastname: von Depka
mesh_terms: D004638:Emergency Treatment; D015942:Factor VIIa / Q000627:therapeutic use*; D006467:Hemophilia A / Q000188:drug therapy; D006487:Hemostasis / Q000502:physiology; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy* / Q000503:physiopathology; D011994:Recombinant Proteins / Q000627:therapeutic use; D012196:Review Literature as Topic
chemical_list: D006490:Hemostatics; D011994:Recombinant Proteins; C103587:recombinant FVIIa; D015942:Factor VIIa