Detection of IgE antibody specific to a hepatitis C virus-derived peptide being recognized by cellular immunity in patients with HCV infection.
The determination of immunogenic peptides of hepatitis C virus (HCV) is pivotal for vaccine development. We previously reported that the majority of patients infected with HCV have significant levels of IgG specific to an HCV-derived peptide at positions 35-44 of core protein (C35-44), a major epitope recognized by cellular immunity. This study addresses whether or not the other subclasses of immunoglobulins to this peptide exist. As a result, IgE, but not IgM or IgA, specific to this peptide is consistently detectable in the majority of patients with HCV infection, regardless of the different HLA types and disease conditions. These results provide additional information on this immunogenic peptide with new insights that contribute to a better understanding of host responses to HCV.
Gohara
Shojiro
S
Department of Immunology, Kurume University School of Medicine, Kurume, Japan.
Shichijo
Shigeki
S
Komatsu
Nobukazu
N
Okuda
Seiya
S
Yutani
Shigeru
S
Itoh
Kyogo
K
D016174:Hepacivirus / Q000276:immunology*; D006526:Hepatitis C / Q000097:blood / Q000276:immunology*; D018937:Hepatitis C Antibodies / Q000097:blood*; D006801:Humans; D007111:Immunity, Cellular; D007073:Immunoglobulin E / Q000097:blood*; D007132:Immunoglobulin Isotypes / Q000097:blood; D010455:Peptides / Q000138:chemical synthesis / Q000276:immunology*; D014758:Viral Core Proteins / Q000138:chemical synthesis / Q000276:immunology
D018937:Hepatitis C Antibodies; D007132:Immunoglobulin Isotypes; D010455:Peptides; D014758:Viral Core Proteins; D007073:Immunoglobulin E