title: Hematopoietic disorders in Down syndrome.
abstract: Patients with Down syndrome have an increased risk of developing various hematological disorders. In this article, the clinical characteristics and differential diagnosis of the hematological disorders associated with Down syndrome are reviewed, and the underlying molecular mechanisms discussed.
authors.affiliation: Children's Hospital of Philadelphia, University of Pennsylvania Philadelphia, PA, USA. choijo@email.chop.edu
authors.forename: John K
authors.initials: JK
authors.lastname: Choi
references.citation: Arch Dis Child. 1990 Feb;65(2):212-6
references.pmid: 2138446
references.citation: Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3339-44
references.pmid: 16492768
references.citation: Clin Haematol. 1978 Feb;7(1):147-54
references.pmid: 148990
references.citation: Leukemia. 2007 Mar;21(3):574-6
references.pmid: 17252020
references.citation: Pediatr Blood Cancer. 2005 Jan;44(1):21-8
references.pmid: 15368546
references.citation: Cancer. 1991 Feb 15;67(4):1057-63
references.pmid: 1825025
references.citation: Leuk Lymphoma. 2003 Jan;44(1):49-58
references.pmid: 12691142
references.citation: Clin Chem. 2003 Sep;49(9):1445-9
references.pmid: 12928224
references.citation: Leukemia. 2004 Oct;18(10):1617-23
references.pmid: 15343346
references.citation: Leuk Res. 1994 Mar;18(3):163-71
references.pmid: 8139285
references.citation: Leuk Lymphoma. 1995 Apr;17(3-4):345-50
references.pmid: 8580807
references.citation: Blood. 1992 May 1;79(9):2399-403
references.pmid: 1349244
references.citation: Br J Haematol. 1989 Nov;73(3):315-22
references.pmid: 2532535
references.citation: Ultrasound Obstet Gynecol. 2001 May;17(5):403-9
references.pmid: 11380964
references.citation: Br J Haematol. 1992 Aug;81(4):520-5
references.pmid: 1390239
references.citation: Am J Med Genet A. 2007 Jan 1;143A(1):42-50
references.pmid: 17163522
references.citation: Am J Med Genet. 1983 Oct;16(2):173-7
references.pmid: 6228141
references.citation: Am J Clin Pathol. 2001 Aug;116(2):204-10
references.pmid: 11488066
references.citation: Arch Pediatr Adolesc Med. 1995 Jul;149(7):824-5
references.pmid: 7795778
references.citation: Leukemia. 1998 May;12(5):645-51
references.pmid: 9593260
references.citation: Pediatr Blood Cancer. 2005 Jan;44(1):13-20
references.pmid: 15534881
references.citation: Pediatr Hematol Oncol. 2005 Sep;22(6):507-12
references.pmid: 16169817
references.citation: Blood. 1998 Jan 15;91(2):608-15
references.pmid: 9427716
references.citation: J Pediatr. 2006 May;148(5):687-9
references.pmid: 16737888
references.citation: Br J Haematol. 2004 Jun;125(6):729-42
references.pmid: 15180862
references.citation: Leukemia. 2003 Feb;17(2):277-82
references.pmid: 12592323
references.citation: Br J Haematol. 2007 May;137(4):337-41
references.pmid: 17456055
references.citation: Clin Lab Med. 1999 Mar;19(1):157-67, vii
references.pmid: 10403079
references.citation: Blood. 1992 Sep 15;80(6):1521-7
references.pmid: 1387814
references.citation: J Pediatr Hematol Oncol. 2003 May;25(5):348-61
references.pmid: 12759620
references.citation: Cancer Genet Cytogenet. 1987 Sep;28(1):55-76
references.pmid: 2955886
references.citation: Med Pediatr Oncol. 1987;15(1):38-41
references.pmid: 2951583
references.citation: MMWR Morb Mortal Wkly Rep. 2006 Jan 6;54(51):1301-5
references.pmid: 16397457
references.citation: Leukemia. 1995 Sep;9(9):1432-9
references.pmid: 7658708
references.citation: Blood. 1995 Oct 15;86(8):3097-108
references.pmid: 7579404
references.citation: Genes Chromosomes Cancer. 2002 Jan;33(1):22-8
references.pmid: 11746984
references.citation: J Pediatr. 1963 Jul;63:1-10
references.pmid: 13975104
references.citation: J Clin Oncol. 1992 Sep;10(9):1419-29
references.pmid: 1517785
references.citation: Blood. 2006 Jun 15;107(12):4606-13
references.pmid: 16469874
references.citation: Am J Pediatr Hematol Oncol. 1993 Nov;15(4):392-9
references.pmid: 8214361
references.citation: J Pediatr. 1984 Aug;105(2):235-42
references.pmid: 6235337
references.citation: Nat Genet. 2001 Jul;28(3):220-1
references.pmid: 11431691
references.citation: Curr Opin Cell Biol. 1995 Dec;7(6):870-7
references.pmid: 8608018
references.citation: Br J Haematol. 2005 Feb;128(4):548-51
references.pmid: 15686466
references.citation: Blood. 2006 Feb 15;107(4):1570-81
references.pmid: 16249385
references.citation: Blood. 2005 Dec 15;106(13):4043-9
references.pmid: 16109782
references.citation: Pediatr Blood Cancer. 2005 Jan;44(1):8-12
references.pmid: 15390275
references.citation: JAMA. 1983 Apr 15;249(15):2034-8
references.pmid: 6220164
references.citation: Cancer. 1987 Nov 15;60(10):2515-20
references.pmid: 2959356
references.citation: Blood Cells Mol Dis. 2003 Nov-Dec;31(3):351-6
references.pmid: 14636651
references.citation: Lancet. 1990 Jan 13;335(8681):117
references.pmid: 1967407
references.citation: Blood. 1992 Nov 1;80(9):2210-4
references.pmid: 1384797
references.citation: Br J Haematol. 2000 Sep;110(3):512-24
references.pmid: 10997960
references.citation: Semin Perinatol. 1997 Feb;21(1):97-101
references.pmid: 9190039
references.citation: Curr Opin Pediatr. 2007 Feb;19(1):9-14
references.pmid: 17224656
references.citation: Ultrasound Obstet Gynecol. 2003 May;21(5):486-9
references.pmid: 12768562
references.citation: Hum Pathol. 1991 Dec;22(12):1274-80
references.pmid: 1836197
references.citation: Leukemia. 1996 Nov;10(11):1677-86
references.pmid: 8892666
references.citation: Ann N Y Acad Sci. 2004 Jun;1022:90-9
references.pmid: 15251945