title: Facial wrinkles as a predictor of decreased renal function.
abstract: OBJECTIVE
  Oxidative stress generated either by exogenous or endogenous sources can lead to progressive organ damage and skin ageing over a long period of time. Moreover, some dermatological signs are independent of chronological ageing, and may reflect the long-term redox state of internal organs. Therefore, we hypothesized that there might be an association between facial wrinkles and decreased renal function, an oxidative stress-related disease.
  
  
  METHODS
  A cross-sectional study was carried out in a Korean population of 264 adults aged 30 years and older. Facial wrinkle scores in the crow's-foot area were estimated using a standardized form of visual assessment. As an index of renal function, we determined estimated glomerular filtration rate (eGFR). Lipid hydroperoxide (LPO) assay was performed to measure the levels of oxidative stress.
  
  
  RESULTS
  After adjusting for possible confounders, lower eGFRs and higher LPO levels were found in those with severe facial wrinkles.
  
  
  CONCLUSIONS
  We conclude that severe facial wrinkles might be used as a predictive marker of decreased renal function, independently of age, gender and other established risk factors.
authors.affiliation: Department of Biochemistry, Chonbuk National University, Jeonju, Jeonbuk, Republic of Korea.
authors.forename: Byung-Hyun
authors.initials: BH
authors.lastname: Park
authors.forename: Sik
authors.initials: S
authors.lastname: Lee
authors.forename: Jin-Woo
authors.initials: JW
authors.lastname: Park
authors.forename: Kyung-Ah
authors.initials: KA
authors.lastname: Kim
authors.forename: Han-Uk
authors.initials: HU
authors.lastname: Kim
authors.forename: Ju-Hyung
authors.initials: JH
authors.lastname: Lee
authors.forename: Dai-Ha
authors.initials: DH
authors.lastname: Koh
authors.forename: Jung-Ho
authors.initials: JH
authors.lastname: Youm
authors.forename: Nina
authors.initials: N
authors.lastname: Yoo
authors.forename: Sue-Kyung
authors.initials: SK
authors.lastname: Park
authors.forename: Keun-Sang
authors.initials: KS
authors.lastname: Kwon
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005145:Face; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D015595:Skin Aging