title: Eosinophil cationic protein, soluble egg antigen, circulating anodic antigen, and egg excretion in male urogenital schistosomiasis.
abstract: Markers of male genital schistosomiasis (MGS) are needed to elucidate the consequences for reproductive health. Eosinophil cationic protein (ECP) and soluble egg antigen (SEA) in urine and semen, and circulating anodic antigen (CAA) in serum were assessed as MGS markers. Egg counts, ECP, and SEA in urine and CAA in serum, correlated positively. Seminal egg excretion exhibited marked day-to-day variations, but counts correlated positively with urinary egg counts and SEA in semen and with CAA. Positive predictive values with reference to seminal egg excretion were as follows: seminal ECP (52%), seminal SEA (83%), CAA (97%), and urinary egg excretion (82%). SEA in semen and CAA in serum constitute potential markers of MGS. However, urine egg counts as an indirect marker of MGS remains the preferred diagnostic method from a public health perspective.
authors.affiliation: DBL Centre for Health Research and Development, Institute of Veterinary Pathobiology, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark. apd@sks.aaa.dk
authors.forename: Peter D C
authors.initials: PD
authors.lastname: Leutscher
authors.forename: Govert T J
authors.initials: GT
authors.lastname: van Dam
authors.forename: Claus M
authors.initials: CM
authors.lastname: Reimert
authors.forename: Charles-Emile
authors.initials: CE
authors.lastname: Ramarakoto
authors.forename: André M
authors.initials: AM
authors.lastname: Deelder
authors.forename: Niels
authors.initials: N
authors.lastname: Ørnbjerg
mesh_terms: D000293:Adolescent; D000328:Adult; D000947:Antigens, Helminth / Q000032:analysis* / Q000097:blood / Q000652:urine; D047150:Eosinophil Cationic Protein / Q000032:analysis / Q000652:urine*; D006023:Glycoproteins / Q000097:blood; D015801:Helminth Proteins / Q000097:blood; D006801:Humans; D008270:Madagascar / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010063:Ovum / Q000276:immunology; D010270:Parasite Egg Count; D012553:Schistosomiasis haematobia / Q000175:diagnosis* / Q000453:epidemiology / Q000469:parasitology; D012661:Semen / Q000276:immunology / Q000469:parasitology*; D012680:Sensitivity and Specificity; D014556:Urine / Q000469:parasitology
chemical_list: D000947:Antigens, Helminth; D006023:Glycoproteins; D015801:Helminth Proteins; C090907:circulating anodic antigen, Schistosoma mansoni; D047150:Eosinophil Cationic Protein