Crosstalk between c-Myc and ribosome in ribosomal biogenesis and cancer.
Protein production is driven by protein translation and relies on ribosomal biogenesis, globally essential for cell growth, proliferation, and animal development. Deregulation of these sophisticated cellular processes leads to abnormal homeostasis and carcinogenesis. Thus, their tight regulation is vitally important for a cell to warrant normal growth and proliferation. One newly identified key regulator for ribosomal biogenesis and translation is the oncoprotein c-Myc, whose aberrantly excessive level and activity are highly associated with human cancers, too. Recently, we have shown that ribosomal protein L11 functions as a feedback regulator of c-Myc. Hence, in this review, we will provide some prospects on the interplay between c-Myc and ribosomal proteins during ribosomal biogenesis and discuss its implications in cancer.
Dai
Mu-Shui
MS
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine and Simon Cancer Center, Indianapolis, Indiana 46202, USA.
Lu
Hua
H
D000818:Animals; D002453:Cell Cycle; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D014176:Protein Biosynthesis; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*; D012269:Ribosomal Proteins / Q000378:metabolism; D012270:Ribosomes / Q000378:metabolism*
D016271:Proto-Oncogene Proteins c-myc; D012269:Ribosomal Proteins; C027624:ribosomal protein L11
J Cell Biol. 1998 May 4;141(3):741-53
9566973
EMBO J. 2007 Jul 25;26(14):3332-45
17599065
J Biol Chem. 2006 Aug 25;281(34):24304-13
16803902
Mol Cell. 2003 May;11(5):1177-88
12769843
Mol Cell Biol. 2006 Sep;26(17):6656-63
16914746
Nat Cell Biol. 2005 Mar;7(3):311-8
15723054
Nat Rev Genet. 2007 Sep;8(9):711-23
17680008
Blood. 2000 Dec 1;96(12):3985-7
11090089
Nature. 2003 Jan 16;421(6920):290-4
12529648
Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3260-5
10737792
Nat Rev Cancer. 2002 Oct;2(10):764-76
12360279
Oncogene Res. 1988 Sep;3(2):155-66
3226724
Neoplasia. 2006 Aug;8(8):630-44
16925946
Cell Cycle. 2004 Apr;3(4):452-5
14976427
Nature. 1990 Jun 7;345(6275):544-7
2348862
Mol Cell Biol. 1993 Dec;13(12):7652-65
8246982
Oncogene. 2004 Apr 19;23(18):3172-9
15094766
J Biol Chem. 1998 Sep 25;273(39):25261-71
9737991
Nat Genet. 1999 Feb;21(2):169-75
9988267
Science. 2003 Jan 10;299(5604):259-62
12522253
Nat Rev Mol Cell Biol. 2007 Jul;8(7):574-85
17519961
Nucleic Acids Res. 1998 Nov 15;26(22):5036-44
9801297
Genes Dev. 2002 Oct 1;16(19):2497-508
12368261
J Biol Chem. 2007 Feb 23;282(8):5790-800
17170115
Adv Cancer Res. 1991;56:1-48
2028839
Nature. 2004 Mar 18;428(6980):332-7
15029198
Oncogene. 1999 May 13;18(19):2942-54
10378691
Genes Dev. 1993 Apr;7(4):671-82
8458579
PLoS One. 2007 Feb 21;2(2):e242
17311107
Nature. 1985 Dec 12-18;318(6046):533-8
3906410
Nat Med. 2004 May;10(5):484-6
15098029
Am J Hum Genet. 2006 Dec;79(6):1110-8
17186470
Mol Cell. 1999 May;3(5):565-77
10360173
Mol Cell Biol. 1996 Jul;16(7):3511-22
8668167
Hum Mutat. 2007 Dec;28(12):1178-82
17647292
Cell. 2008 Apr 4;133(1):78-89
18394991
Nat Cell Biol. 2005 Mar;7(3):215-7
15738972
Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1065-70
8577715
Curr Opin Cell Biol. 2002 Jun;14(3):313-8
12067653
J Biol Chem. 2007 Mar 16;282(11):8052-9
17242401
Cancer Res. 2000 Nov 1;60(21):5922-8
11085504
Cell. 2005 Mar 11;120(5):623-34
15766526
Nat Cell Biol. 2005 Mar;7(3):295-302
15723055
Cell. 2002 May 3;109(3):321-34
12015982
EMBO J. 2003 Nov 17;22(22):6068-77
14609953
Oncogene. 2007 Aug 2;26(35):5029-37
17310983
J Biol Chem. 1996 Apr 5;271(14):8144-51
8626503
Mol Cell Biol. 1991 Nov;11(11):5435-45
1922056
Cell Cycle. 2004 Sep;3(9):1133-7
15467447
Front Biosci. 1998 Mar 26;3:d376-98
9514985
J Biol Chem. 2004 Oct 22;279(43):44475-82
15308643
Cancer Cell. 2003 Jun;3(6):577-87
12842086
Nat Rev Mol Cell Biol. 2005 Aug;6(8):635-45
16064138
Cell. 2001 Jan 26;104(2):195-203
11207361
Mol Cell Biol. 2004 Sep;24(17):7654-68
15314173
Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13180-5
10557294
Blood. 2008 Sep 1;112(5):1582-92
18535205
Nat Rev Cancer. 2004 Jul;4(7):562-8
15229481
Nat Cell Biol. 2005 Mar;7(3):303-10
15723053
Mol Cell Biol. 2003 Dec;23(23):8902-12
14612427
Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11198-202
11005843
Cell Cycle. 2007 Nov 15;6(22):2735-41
18032916
Mol Cell. 1999 Aug;4(2):199-207
10488335
J Biol Chem. 2008 May 2;283(18):12387-92
18305114
EMBO J. 2001 Mar 15;20(6):1383-93
11250904
Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6274-9
11983916
Trends Biochem Sci. 1999 Nov;24(11):437-40
10542411
Mol Cell. 2003 May;11(5):1189-200
12769844
Nat Genet. 2007 Apr;39(4):486-95
17353896
Nature. 2006 Jun 15;441(7095):898-901
16778892
Cancer Res. 1997 Nov 15;57(22):5041-4
9371500
Mol Cell Biol. 2006 Dec;26(23):8880-91
17000767
Nature. 2008 Jan 17;451(7176):335-9
18202658
Nat Rev Cancer. 2003 Mar;3(3):179-92
12612653
Nucleic Acids Res. 2003 Nov 1;31(21):6148-56
14576301
Nat Genet. 2002 Jul;31(3):301-5
12053177
Oncogene. 2004 Apr 19;23(18):3189-99
15094768