Design and development of curcumin bioconjugates as antiviral agents.
A number of curcumin bioconjugates with fatty acid, dipeptide and folic acid, viz. di-O-decanoyl curcumin (2), di-O-tryptophanylphenylalanine curcumin (3), di-O-bis-(gamma, gamma)folyl curcumin (4), C(4)-ehyl-O-gamma-folyl curcumin (5) and 4-O-ethyl-O-gamma-folyl curcumin (6) have been synthesized. Conjugates 2-6 have shown good antiviral property with EC(50) ranging between 0.019-0.105 microM against a wide range of viruses, like HIV, HSV, VSV and many others.
Rai
Diwakar
D
Nucleic Acids Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad-211002, India.
Yadav
Dipti
D
Balzarini
J
J
De Clercq
E
E
Singh
Ramendra K
RK
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D003474:Curcumin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D015195:Drug Design
D000998:Antiviral Agents; D003474:Curcumin