title: Synthesis and antiviral evaluation of 7-fluoro-7-deaza-2-aminopurine nucleoside derivatives.
abstract: Three 7-fluoro-7-deaza-2-aminopurine nucleoside derivatives were synthesized and evaluated as potential inhibitors of RNA virus replication, including hepatitis C virus (HCV).
authors.affiliation: Idenix Pharmaceuticals, Medicinal Chemistry Laboratory, Cap Gamma, 1682 Rue de la Valsière, 34189 Montpellier Cedex 4, France. Leroy.frederic@idenix.com
authors.forename: Frederic
authors.initials: F
authors.lastname: Leroy
authors.forename: Dominique
authors.initials: D
authors.lastname: Chaves
authors.forename: David
authors.initials: D
authors.lastname: Dukhan
authors.forename: Richard
authors.initials: R
authors.lastname: Storer
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Sommadossi
authors.forename: Anna Giulia
authors.initials: AG
authors.lastname: Loi
authors.forename: Alessandra
authors.initials: A
authors.lastname: Cadeddu
authors.forename: Maura
authors.initials: M
authors.lastname: Fanti
authors.forename: Nadia
authors.initials: N
authors.lastname: Boscu
authors.forename: Fabiola
authors.initials: F
authors.lastname: Bassetti
authors.forename: Michel
authors.initials: M
authors.lastname: Liuzzi
authors.forename: Gilles
authors.initials: G
authors.lastname: Gosselin
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D016174:Hepacivirus / Q000187:drug effects; D011684:Purine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D011684:Purine Nucleosides