title: [Feasibilities of laboratory diagnosis of cognitive disorders in dyscirculatory encephalopathy].
abstract: A hundred and sixty-nine patients aged 51-80 years who had Stages I and II dyscirculatory encephalopathy were examined. A control group comprised 32 apparently healthy individuals of the same age. Cognitive disorders were rated using the mini-mental state examination (MMSE) scale. The serum activities of butyrylcholine esterase (BCE) and gamma-glutamyl transferase (gamma-GT) were studied. The development of moderate cognitive disorders was found to be accompanied by lower BCE and higher gamma-GT activities. The activity levels of these enzymes may be used as markers reflecting the cholinergic and glutamatergic neuromediatory systems involved in cognitive functions.
authors.forename: S G
authors.initials: SG
authors.lastname: Bugrova
authors.forename: E V
authors.initials: EV
authors.lastname: Bobyreva
authors.forename: M V
authors.initials: MV
authors.lastname: Zelinskaia
authors.forename: T E
authors.initials: TE
authors.lastname: Kirpicheva
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002561:Cerebrovascular Disorders / Q000150:complications*; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged