Drug-induced hyperbilirubinemia and the clinical influencing factors.
Hyperbilirubinemia may accompany harmful effects such as jaundice, brain dysfunction, and pharmacokinetic alterations of drugs. Clinical drugs are the important causes of hyperbilirubinemia, especially for patients with certain pathologic conditions or with genetic variations. This article reviews hyperbilirubinemic pathophysiology with respect to the effects of clinical drugs. In addition, this review introduces a new formula that may be utilized to estimate the annual occurrences of drug-induced hyperbilirubinemia in a hospital. Variations in the genes of UDP-glucuronosyltransferases, organic anion-transporting polypeptides and multidrug resistance proteins are the predisposing factors for drug-induced hyperbilirubinemia; therefore, their genetic and ethnic polymorphisms are discussed.
Ah
Young-Mi
YM
Department of Pharmacy, Seoul National University Hospital, Seoul, Korea.
Kim
Young-Mi
YM
Kim
Min-Jung
MJ
Choi
Young Hee
YH
Park
Kyoung-Ho
KH
Son
In-Ja
IJ
Kim
Sang Geon
SG
D000818:Animals; D064420:Drug-Related Side Effects and Adverse Reactions; D014453:Glucuronosyltransferase / Q000235:genetics / Q000378:metabolism; D006801:Humans; D006932:Hyperbilirubinemia / Q000139:chemically induced* / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D007565:Jaundice / Q000139:chemically induced / Q000201:enzymology / Q000235:genetics / Q000378:metabolism; D011110:Polymorphism, Genetic / Q000187:drug effects / Q000502:physiology
D014453:Glucuronosyltransferase