[Dehydroepiandrosterone sulfate effect at the conversion of corticosterone to 11-dehydrocorticosterone in stress conditions: the scheme of regulation].
It had been shown that the reaction of conversion of corticosterone (CS) to 11-dehydrocorticosterone (11-DHCS) was increased in chronic intermissions, but not in sharp stress influences in male rats, especially under dehydroepiandrosterone sulfate (DHEAS) employment. The injection of naltrexone 20 min before DHEAS in dose 0.1 mg/kg which selectively blocked the mu-opiate receptors canceled this effect that indicated the participation of in-opiate receptors in such regulation. The DHEAS effect realized through the endogenous ACTH, and such was of the central nature. On the base of ourselves and the literature dates we intraduced the scheme of DHEAS- and mu-opiate-dependent regulation of CS/11-DHCS interchangings.
Obut
T A
TA
Ovsiukova
M V
MV
Dement'eva
T Iu
TIu
Cherkasova
O P
OP
Saryg
S K
SK
Grigor'eva
T A
TA
D000818:Animals; D003345:Corticosterone / Q000031:analogs & derivatives* / Q000378:metabolism*; D019314:Dehydroepiandrosterone Sulfate / Q000494:pharmacology*; D008297:Male; D009271:Naltrexone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017450:Receptors, Opioid, mu / Q000378:metabolism*; D013312:Stress, Physiological / Q000378:metabolism*
D009292:Narcotic Antagonists; D017450:Receptors, Opioid, mu; D019314:Dehydroepiandrosterone Sulfate; D009271:Naltrexone; C003552:11-dehydrocorticosterone; D003345:Corticosterone