title: [Parkinson disease and amyotrophic lateral sclerosis. Tauopathies, TDP-43 and SOD mutations].
abstract: In addition to a large number of clinical descriptions of atypical cases, recent pathological, biochemical and genetic studies challenge the view that amyotrophic lateral sclerosis (ALS) is a disorder restricted to the pyramidal motor system. Relations between ALS, Parkinson disease, fronto-temporal dementia, progressive supranuclear paralysis, and cortico-basal degeneration have now been identified. We propose a review of the topic and discuss the contribution of various clinical and pathological features leading to consider motoneuron diseases as neurodegenerative processes included in a broad spectrum of tauopathies.
authors.affiliation: Pôle neurologique, fédération des maladies du système nerveux, hôpital de la Pitié-Salpêtrière, 47-83, boulevard de l'Hôpital, 75651 Paris cedex 13, France. nadine.leforestier@psl.aphp.fr
authors.forename: N
authors.initials: N
authors.lastname: Le Forestier
authors.forename: L
authors.initials: L
authors.lastname: Lacomblez
authors.forename: V
authors.initials: V
authors.lastname: Meininger
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D001480:Basal Ganglia Diseases / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D009154:Mutation / Q000235:genetics / Q000502:physiology; D010300:Parkinson Disease / Q000235:genetics* / Q000378:metabolism; D013482:Superoxide Dismutase / Q000235:genetics* / Q000378:metabolism*; D016875:tau Proteins / Q000235:genetics* / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D016875:tau Proteins; D013482:Superoxide Dismutase