[Design and synthesis of a type of benzopyran derivatives with insulin-sensitizing activity].
Ten novel compounds were designed and synthesized on the basis of compound 1, their insulin-sensitizing activities were evaluated in 3T3-L1 cells. Results showed that compound 10 exhibited strong differentiation-stimulating activity on 3T3-L1 cells model, which indicated that compound 10 may possess well insulin-sensitizing activity.
Tang
Lei
L
School of Pharmacy, Guiyang Medical College, Guiyang 550004, China. tlei1974@hotmail.com
Li
Yu
Y
Yu
Juan-Hong
JH
Yang
Yu-She
YS
Ji
Ru-Yun
RY
D041721:3T3-L1 Cells; D000818:Animals; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000494:pharmacology; D015195:Drug Design; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology*; D051379:Mice
D001578:Benzopyrans; D007004:Hypoglycemic Agents; D007328:Insulin