Effect of citalopram in treating hypersexuality in an Alzheimer's disease case.
Hypersexuality in Alzheimer's disease (AD) has been rarely investigated. Hypersexual behaviours should be classified as a sexual obsession and included in the "obsessive-compulsive disorder-like" spectrum. Hypersexuality has no proven treatment, although reports have described reductions of this behaviour using antiandrogen treatment, H2-receptor antagonists and antipsychotic drugs. Serotonin reuptake blockers seem to be effective in the treatment of sexual obsessions or compulsions and less on paraphilic disturbances. We present the case of a 54-year-old male patient with Alzheimer's disease with compulsive sexual behaviour as reported by his wife. A 18-FDG PET scan evidenced prevalent hypometabolism of the right hemisphere, congruent with neuropsychological evaluation. Donepezil, 10 mg per day, produced cognitive improvement but no effects on sexual behaviour. Therapy with SSRI was subsequently started (citalopram): after 60 days, the patient showed improvement in both the compulsive pursuit of sex acts and the level of frustration when refused.
Tosto
Giuseppe
G
Clinica della Memoria, Department of Neurological Science La Sapienza Rome, Rome, Italy. giuseppe.tosto@yahoo.it
Talarico
Giuseppina
G
Lenzi
Gian Luigi
GL
Bruno
Giuseppe
G
D000544:Alzheimer Disease / Q000150:complications* / Q000188:drug therapy / Q000523:psychology; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology*; D015283:Citalopram / Q000008:administration & dosage*; D003072:Cognition Disorders / Q000209:etiology; D018450:Disease Progression; D000077265:Donepezil; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007189:Indans / Q000627:therapeutic use; D008297:Male; D008569:Memory Disorders / Q000209:etiology; D008875:Middle Aged; D019964:Mood Disorders / Q000209:etiology; D018697:Nootropic Agents / Q000627:therapeutic use; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D010880:Piperidines / Q000627:therapeutic use; D049268:Positron-Emission Tomography; D012701:Serotonin / Q000378:metabolism; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage*; D012725:Sexual Behavior / Q000187:drug effects; D020018:Sexual Dysfunctions, Psychological / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D016896:Treatment Outcome
D015283:Citalopram; D000077265:Donepezil; D019788:Fluorodeoxyglucose F18; D007189:Indans; D018697:Nootropic Agents; D010880:Piperidines; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors