Molecular insights into mechanisms regulating faithful chromosome separation in female meiosis.
The faithful segregation of chromosomes into daughter cells in meiosis is crucial to produce healthy progeny. In gametogenesis, two consecutive rounds of chromosome separation occur with only one round of DNA replication, and the chromosome number is reduced to half to produce haploid gametes. Here, we discuss the molecular mechanisms underlying faithful chromosome separation in meiosis from three aspects: spindle checkpoint, two-step releases of cohesion, and the specific space-time protection of cohesin.
Yin
Shen
S
State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Sun
Xiao-Fang
XF
Schatten
Heide
H
Sun
Qing-Yuan
QY
D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism; D020090:Chromosome Segregation / Q000502:physiology*; D005260:Female; D006801:Humans; D018386:Kinetochores / Q000378:metabolism; D008540:Meiosis; D008954:Models, Biological; D008941:Spindle Apparatus / Q000502:physiology; D000097722:Cohesins
D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D000097722:Cohesins