title: Molecular domains of myelinated axons in the peripheral nervous system.
abstract: Myelinated axons are organized into a series of specialized domains with distinct molecular compositions and functions. These domains, which include the node of Ranvier, the flanking paranodal junctions, the juxtaparanodes, and the internode, form as the result of interactions with myelinating Schwann cells. This domain organization is essential for action potential propagation by saltatory conduction and for the overall function and integrity of the axon.
authors.affiliation: Department of Cell Biology and Neurology, and the Smilow Neuroscience Program, NYU School of Medicine, New York, New York 10016.
authors.forename: James L
authors.initials: JL
authors.lastname: Salzer
authors.affiliation: Centre for Neuroscience Research, University of Edinburgh, Edinburgh EH9 1QH, United Kingdom.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Brophy
authors.affiliation: Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.
authors.forename: Elior
authors.initials: E
authors.lastname: Peles
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001369:Axons / Q000502:physiology / Q000648:ultrastructure; D003599:Cytoskeleton / Q000378:metabolism; D006801:Humans; D009413:Nerve Fibers, Myelinated / Q000502:physiology* / Q000648:ultrastructure; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009431:Neural Conduction / Q000502:physiology; D017933:Peripheral Nervous System / Q000166:cytology / Q000502:physiology*; D011901:Ranvier's Nodes / Q000502:physiology / Q000648:ultrastructure; D012583:Schwann Cells / Q000502:physiology* / Q000648:ultrastructure
chemical_list: D009419:Nerve Tissue Proteins