title: Conversion of optically active hydrindanone to (+)-bakkenolide-A.
abstract: A total synthesis of (+)-bakkenolide-A was carried out via the key intermediate 4, which was prepared based on an asymmetric cyclization-carbonylation reaction established in our laboratory. Diastereoselective construction of the spirolactone moiety was achieved using Mitsuhashi's protocol as a key step.
authors.affiliation: Faculty of Pharmaceutical Sciences, Toho University, Chiba, Japan.
authors.forename: Taichi
authors.initials: T
authors.lastname: Kusakabe
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kato
authors.forename: Satoshi
authors.initials: S
authors.lastname: Motodate
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takaishi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Akita
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis*; D003500:Cyclization; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D012717:Sesquiterpenes; D013148:Spironolactone / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D007202:Indicators and Reagents; D012717:Sesquiterpenes; D013148:Spironolactone; D015107:4-Butyrolactone; C016257:bakkenolide A