title: 5-Oxoproline as a cause of high anion gap metabolic acidosis: an uncommon cause with common risk factors.
abstract: High anion gap metabolic acidosis might be caused by 5-oxoproline (pyroglutamic acid). As it is very easy to treat, it might be worth drawing attention to this uncommon and probably often overlooked diagnosis. We present three cases of high anion gap metabolic acidosis due to 5-oxoproline seen within a period of six months.
authors.affiliation: Department of Internal Medicine, VU University Medical Center, Amsterdam, the Netherlands.
authors.forename: W
authors.initials: W
authors.lastname: Kortmann
authors.forename: M A
authors.initials: MA
authors.lastname: van Agtmael
authors.forename: J
authors.initials: J
authors.lastname: van Diessen
authors.forename: B L J
authors.initials: BL
authors.lastname: Kanen
authors.forename: C
authors.initials: C
authors.lastname: Jakobs
authors.forename: P W B
authors.initials: PW
authors.lastname: Nanayakkara
mesh_terms: D000136:Acid-Base Equilibrium; D000141:Acidosis, Renal Tubular / Q000139:chemically induced* / Q000209:etiology; D000368:Aged; D005260:Female; D006801:Humans; D044342:Malnutrition; D008875:Middle Aged; D011761:Pyrrolidonecarboxylic Acid / Q000009:adverse effects*; D051437:Renal Insufficiency; D012307:Risk Factors
chemical_list: D011761:Pyrrolidonecarboxylic Acid