Bromine-lithium exchange under non-cryogenic conditions: TMSCH(2)Li-LiDMAE promoted C-2 lithiation of 2,3-dibromopyridine.
The first C-2 selective bromine-lithium exchange in 2,3-dibromopyridine was performed at 0 degrees C in toluene using the TMSCH(2)Li-LiDMAE reagent.
Gros
Philippe C
PC
Groupe SOR, SRSMC, CNRS, Nancy Université, Faculté des Sciences, Boulevard des Aiguillettes, F-54506, Vandoeuvre-Lès-Nancy, France. Philippe.Gros@sor.uhp-nancy.fr
Elaachbouni
Fatima
F