Are CD8+CD122+ cells regulatory T cells or memory T cells?
We identified CD8(+)CD122(+) regulatory T cells in the mouse. Some immunologists consider CD8(+)CD122(+) cells to be memory T cells despite our report of their regulatory function. Here, we propose a dual phenotype of these cells. Murine CD8(+)CD122(+) T cells demonstrate both memory and regulatory features in their functional profiles. Human CD8(+)CXCR3(+) T cells, which are thought to be the human counterpart of murine CD8(+)CD122(+) regulatory T cells, do not match human central memory T cells of the CD8(+)CD45RA(-)CCR7(+) phenotype. Thus, we must consider human CD8(+) regulatory T cells and murine CD8(+) regulatory T cells separately. Of human CD8(+) regulatory T cells, CD8(+)CXCR3(+) regulatory T cells can be divided into further subsets and we may be able to distinguish memory T cells and regulatory T cells. Of murine CD8(+)CD122(+) regulatory T cells, it seems to be impossible to divide CD8(+)CD122(+)CD44(+)CD62L(+) regulatory T cells into further subsets at present, indicating that this single population of cells has activities of both regulatory T cells and memory T cells.
Suzuki
Haruhiko
H
Department of Immunology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. harusuzu@med.nagoya-u.ac.jp
Shi
Zhe
Z
Okuno
Yusuke
Y
Isobe
Ken-ichi
K
D000818:Animals; D015703:Antigens, CD / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology* / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory / Q000502:physiology*; D053646:Interleukin-2 Receptor beta Subunit / Q000276:immunology; D051379:Mice; D054400:Receptors, CCR7 / Q000276:immunology; D054367:Receptors, CXCR3 / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000166:cytology* / Q000276:immunology*
D015703:Antigens, CD; C515370:CCR7 protein, human; C515187:CXCR3 protein, human; C515371:Ccr7 protein, mouse; C515188:Cxcr3 protein, mouse; C508022:Il2rb protein, mouse; D053646:Interleukin-2 Receptor beta Subunit; D054400:Receptors, CCR7; D054367:Receptors, CXCR3