[Propionic acid fermentation by Propionibacterium freudenreichii CCTCC M207015 with a fibrous-bed bioreactor].
The production of propionic acid by Propionibacterium freudenreichii CCTCC M207015 was investigated in a Fibrous-bed bioreactor (FBB). The FBB was constructed by packing spiral cotton fibrous and immobilized into a bioreactor. By applying this bioreactor to propionic acid fermentation, the propionic acid yield had a significant improvement and reached 20.41 g/L, compared with the cell-free culture of 14.58 g/L (40 g/L of glucose). At the same time, the glucose exhausting time decreased from 120 h to 60 h. Batch fermentations at various glucose concentrations were carried out with FBB. Based on the analysis of the time course of production, fed-batch fermentation was also applied to produce propionic acid with FBB, the maximal propionic acid yield reached 45.91 g/L, and the proportion of propionic acid to total acids was about 72.31%.
Feng
Xiaohai
X
State Key Laboratory of Materials-Oriented Chemical Engineering, College of Life Science and Pharmacy, Nanjing University of Technology, Nanjing 210009, China.
Wu
Bo
B
Shen
Xiaobo
X
Xu
Hong
H
D019149:Bioreactors / Q000382:microbiology*; D005285:Fermentation; D005947:Glucose / Q000378:metabolism; D011422:Propionates / Q000378:metabolism*; D011424:Propionibacterium / Q000145:classification / Q000378:metabolism*
D011422:Propionates; D005947:Glucose; C029658:propionic acid