title: Rheological investigation on hyaluronan-fibrinogen interaction.
abstract: This paper concerns the interaction between hyaluronan and fibrinogen as model for protein-polysaccharide interaction. From rheological investigation, it is shown that a 3D physical network is promoted by mixing the two components; the mechanism is attributed to electrostatic interactions. The influences of the molecular weight and of the hyaluronan concentration are examined; the loose interaction obtained for addition of small amount of soluble protein induces a non-Newtonian behaviour which may be in direct relation with the behaviour observed previously on synovial fluids.
authors.affiliation: Centre de Recherches sur les Macromolécules Végétales (CERMAV-CNRS) affiliated with Joseph Fourier University, BP53, 38041 Grenoble cedex 9, France. marguerite.rinaudo@cermav.cnrs.fr
authors.forename: Marguerite
authors.initials: M
authors.lastname: Rinaudo
mesh_terms: D005340:Fibrinogen / Q000737:chemistry / Q000378:metabolism*; D006820:Hyaluronic Acid / Q000737:chemistry / Q000378:metabolism*; D008970:Molecular Weight; D012212:Rheology; D055672:Static Electricity; D014783:Viscosity
chemical_list: D005340:Fibrinogen; D006820:Hyaluronic Acid