title: Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial.
abstract: BACKGROUND
  Preliminary evidence is equivocal about the role of exhaled nitric oxide (NO) in clinical asthma management. We aimed to assess whether measurement of exhaled NO, as a biomarker of airway inflammation, could increase the effectiveness of asthma treatment, when used as an adjunct to clinical care based on asthma guidelines for inner-city adolescents and young adults.
  
  
  METHODS
  We did a randomised, double-blind, parallel-group trial at ten centres in the USA. We screened 780 inner-city patients, aged 12-20 years, who had persistent asthma. All patients completed a run-in period of 3 weeks on a regimen based on standard treatment. 546 eligible participants who adhered to treatment during this run-in period were then randomly assigned to 46 weeks of either standard treatment, based on the guidelines of the National Asthma Education and Prevention Program (NAEPP), or standard treatment modified on the basis of measurements of fraction of exhaled NO. The primary outcome was the number of days with asthma symptoms. We analysed patients on an intention-to-treat basis. This trial is registered with clinicaltrials.gov, number NCT00114413.
  
  
  RESULTS
  During the 46-week treatment period, the mean number of days with asthma symptoms did not differ between the treatment groups (1.93 [95% CI 1.74 to 2.11] in the NO monitoring group vs 1.89 [1.71 to 2.07] in the control group; difference 0.04 [-0.22 to 0.29], p=0.780). Other symptoms, pulmonary function, and asthma exacerbations did not differ between groups. Patients in the NO monitoring group received higher doses of inhaled corticosteroids (difference 119 mug per day, 95% CI 49 to 189, p=0.001) than controls. Adverse events did not differ between treatment groups (p>0.1 for all adverse events).
  
  
  CONCLUSIONS
  Conventional asthma management resulted in good control of symptoms in most participants. The addition of fraction of exhaled NO as an indicator of control of asthma resulted in higher doses of inhaled corticosteroids, without clinically important improvements in symptomatic asthma control.
authors.affiliation: National Jewish Health, Denver, CO, USA.
authors.forename: Stanley J
authors.initials: SJ
authors.lastname: Szefler
authors.forename: Herman
authors.initials: H
authors.lastname: Mitchell
authors.forename: Christine A
authors.initials: CA
authors.lastname: Sorkness
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Gergen
authors.forename: George T
authors.initials: GT
authors.lastname: O'Connor
authors.forename: Wayne J
authors.initials: WJ
authors.lastname: Morgan
authors.forename: Meyer
authors.initials: M
authors.lastname: Kattan
authors.forename: Jacqueline A
authors.initials: JA
authors.lastname: Pongracic
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Teach
authors.forename: Gordon R
authors.initials: GR
authors.lastname: Bloomberg
authors.forename: Peyton A
authors.initials: PA
authors.lastname: Eggleston
authors.forename: Rebecca S
authors.initials: RS
authors.lastname: Gruchalla
authors.forename: Carolyn M
authors.initials: CM
authors.lastname: Kercsmar
authors.forename: Andrew H
authors.initials: AH
authors.lastname: Liu
authors.forename: Jeremy J
authors.initials: JJ
authors.lastname: Wildfire
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Curry
authors.forename: William W
authors.initials: WW
authors.lastname: Busse
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D000730:Androstadienes / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D001944:Breath Tests; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D004311:Double-Blind Method; D005260:Female; D000068298:Fluticasone; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D016896:Treatment Outcome; D014505:Urban Population
chemical_list: D000305:Adrenal Cortex Hormones; D000730:Androstadienes; D001993:Bronchodilator Agents; D009569:Nitric Oxide; D000068298:Fluticasone