Dendritic nucleotides: interaction with an aliphatic acid monolayer.
Dendrimeric-T and dendrimeric-A with 36 nucleotides were synthesized using phosphoramidite reagents. These dendrimers contain the nucleosides dA and dT, which are the components of the dA-dT base pair. Branching was obtained using a bifurcated and trifurcated reagent. The dendrimers were purified by ion-exchange chromatography. No specific interactions between these dendrimers were observed using atomic force microscopy. However, the dendrimeric-T is able to disrupt monolayers of fatty acids, resulting in a reorientation of the lipids (from head-to-tail to head-to-head) as demonstrated by scanning tunneling microscopy (STM).
Wang
Guojie
G
Division of Molecular and Nanomaterials, Department of Chemistry, K.U. Leuven, Celestijnenlaan 200 F, BE-3001 Heverlee.
Abramov
Mikhail
M
Van Aerschot
Arthur
A
Rozenski
Jef
J
Lei
Shengbin
S
Klymchenko
Andrei
A
Van der Auweraer
Mark
M
De Feyter
Steven
S
Herdewijn
Piet
P
D002851:Chromatography, High Pressure Liquid; D050091:Dendrimers / Q000737:chemistry*; D005227:Fatty Acids / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D016252:Microscopy, Scanning Tunneling; D015394:Molecular Structure; D009711:Nucleotides / Q000138:chemical synthesis / Q000737:chemistry*
D050091:Dendrimers; D005227:Fatty Acids; D009711:Nucleotides