Renal resistive index and renal function before and after paracentesis in patients with hepatorenal syndrome and tense ascites.
OBJECTIVE
To assess the effect of reducing intra-abdominal pressure (IAP) by paracentesis on renal resistive index (RI), hemodynamics and renal function.


METHODS
Uncontrolled trial in a university gastroenterological intensive care unit.


METHODS
Twelve spontaneously breathing cirrhotic patients with hepatorenal syndrome, tense ascites and a clinical indication for paracentesis.


METHODS
Paracentesis and substitution of albumin.


RESULTS
Hemodynamic variables were assessed by transpulmonary thermodilution, RI was determined by Doppler ultrasound of renal interlobar arteries. After paracentesis and albumin substitution, there was a significant decrease of IAP (20 mmHg (19-22) to 12 mmHg (10-13), systemic vascular resistance index (from 1,243 dyn s/cm(5)/m(2) (1,095-1,745) to 939 dyn s/cm(5)/m(2) (812-1,365); p = 0.005) and RI (from 0.848 (0.810-0.884) to 0.810 (0.780-0.826); p = 0.003). Arterial compliance increased from 1.33 mL/mmHg (0.89-1.74) to 1.71 mL/mmHg (1.21-2.12), pulse pressure index remained unchanged. Creatinine clearance (ClCreat) increased significantly from 5 mL/min (0-28) to 9 mL/min (0-36) (p = 0.018) and urinary output from 12 mL/h (0-49) to 16 mL/h (0-64) (p = 0.043).


CONCLUSIONS
In patients with cirrhosis, HRS and tense ascites, IAP may contribute to renal dysfunction. Reduction of IAP following paracentesis and albumin substitution may improve ClCreat, probably by improving renal blood flow as reflected by decreasing RI in Doppler ultrasound.
Umgelter
Andreas
A
II. Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Ismaninger Str. 22, 81675, Munich, Germany. andreas.umgelter@lrz.tu-muenchen.de
Reindl
Wolfgang
W
Franzen
Michael
M
Lenhardt
Cosima
C
Huber
Wolfgang
W
Schmid
Roland M
RM
D000328:Adult; D000418:Albumins / Q000008:administration & dosage; D001201:Ascites / Q000503:physiopathology* / Q000628:therapy*; D015331:Cohort Studies; D005260:Female; D006439:Hemodynamics; D006530:Hepatorenal Syndrome / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D007262:Infusions, Intravenous; D007668:Kidney / Q000503:physiopathology*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D019152:Paracentesis; D010952:Plasma Substitutes / Q000008:administration & dosage
D000418:Albumins; D010952:Plasma Substitutes