Three-component one-pot synthesis of 4,6-diarylpyrimidin- 2(1H)-ones under solvent-free conditions in the presence of sulfamic acid as a green and reusable catalyst.
A rapid and efficient one-pot method for the synthesis of 4,6-diarylpyrimidin-2(1H)-ones and related heterocycles is described. The condensation of acetophenone derivatives, aldehydes and urea in the presence of sulfamic acid was employed to synthesize a variety of pyrimidinones in moderate to excellent yields. The scope and limitations of this method are described.
Heravi
Majid M
MM
Department of Chemistry, School of Sciences, Azzahra University, Vanak, Tehran, Iran. mmh1331@yahoo.com
Ranjbar
Leila
L
Derikvand
Fatemeh
F
Alimadadi
Behnoush
B
D002384:Catalysis; D003247:Conservation of Natural Resources; D009682:Magnetic Resonance Spectroscopy; D008722:Methods; D015394:Molecular Structure; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000737:chemistry; D012997:Solvents; D013055:Spectrophotometry, Infrared; D013451:Sulfonic Acids
D011744:Pyrimidinones; D012997:Solvents; D013451:Sulfonic Acids; C005741:sulfamic acid