Isolation, structure determination, and synthesis of galaxamide, a rare cytotoxic cyclic pentapeptide from a marine algae Galaxaura filamentosa.
Galaxamide (1), a rare cyclic pentapeptide, was isolated from the marine algae Galaxaura filamentosa. A preliminary bioassay of Galaxamide showed remarkable in vitro antiproliferative activities against GRC-1 and HepG2 cell lines. The first total synthesis of the cyclic peptide was achieved for further biological evaluation.
Xu
Wen-Jie
WJ
Institute of Hydrobiology, Jinan University, Huangpu Road West 601, Guangzhou, Guangdong 510632, People's Republic of China.
Liao
Xiao-Jian
XJ
Xu
Shi-Hai
SH
Diao
Jian-Zhong
JZ
Du
Bin
B
Zhou
Xu-Long
XL
Pan
Shan-Shan
SS
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification* / Q000633:toxicity; D000461:Rhodophyta / Q000737:chemistry*
D010456:Peptides, Cyclic; C533373:galaxamide