[Chronic effect of thyroxine on behavior and brain serotonin receptors in mice with the sharp difference in predisposition to catalepsy].
Effects of chronic thyroxine treatment (2mg/l, 60 days) on catalepsy, functional activity and expression of 5-HT(1A) and 5-HT(2A) receptors genes in the brain were studied in adult males of catalepsy-prone ASC and catalepsy-resistant AKR mouse strains. Thyroxine caused an appearance of cataleptics in AKR, but produced an anticataleptic effect on ASC mice. Chronic thyroxine treatment increased the functional activity and expression of 5-HT(2A) receptors in the frontal cortex in AKR, but not in ASC mice. Hormone markedly attenuated hypothermic effect of 8-OH-DPAT, 5-HT(1A) receptor agonist, but did not affect the expression of 5-HT(1A) receptors in ASC mice. The results suggest the involvement of the 5-HT(2A) receptors in the cataleptogenic and the 5-HT(1A) receptors in the anticataleptic effects of hormone.
Zubkov
E A
EA
Kulikov
A V
AV
Naumenko
V S
VS
Popova
N K
NK
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002375:Catalepsy / Q000188:drug therapy / Q000503:physiopathology*; D005625:Frontal Lobe / Q000378:metabolism; D007036:Hypothermia, Induced; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D044282:Receptor, Serotonin, 5-HT1A / Q000378:metabolism*; D044402:Receptor, Serotonin, 5-HT2A / Q000378:metabolism*; D058825:Serotonin 5-HT1 Receptor Agonists; D058826:Serotonin 5-HT2 Receptor Agonists; D013045:Species Specificity; D013974:Thyroxine / Q000494:pharmacology* / Q000627:therapeutic use
D044402:Receptor, Serotonin, 5-HT2A; D058825:Serotonin 5-HT1 Receptor Agonists; D058826:Serotonin 5-HT2 Receptor Agonists; D044282:Receptor, Serotonin, 5-HT1A; D013974:Thyroxine