title: Hypocholesterolemic effects of dietary soybean vs. casein proteins in a crossed over diets in rat.
abstract: To investigate the effects of dietary proteins on the level of serum total cholesterol (TC), triglyceride (TG) and high density lipoprotein (HDL), 32 male Wistar rats were randomly divided in control and 3 experimental groups (El, E2 and E3). The feeding regimes of rats were as follow: control, standard diet; E1, a cholesterol free diet containing 20% soybean protein; E2, a cholesterol free diet containing 20% casein and E3, a cholesterol free diet containing 10% soybean protein and 10% casein. The experimental period was 11 weeks but at the end of 7th week the diets of E1 and E2 groups were crossed over for the next 4 weeks. Blood samples were collected weekly, via the ophthalmic sinus and the serum levels TC, TG and HDL were measured. In comparison with control group, the results show that at the end of 7th week TC levels in E1 and E2 groups were significantly (p<0.05) increased while HDL level unchanged and the TC value of E2 was bigger (not significant) than E1. However by crossing over the diets, the TC level was significantly (p<0.05) diminished in E2 while TG value remarkably (p<0.05) increased. These results indicate that soybean protein may insert its hypocholesterolemic effect in hypercholestrolemic condition than in normolipidemic condition.
authors.affiliation: School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Nikravesh Mohammad
authors.initials: NM
authors.lastname: Reza
authors.forename: Behnam-Rassouli
authors.initials: BR
authors.lastname: Fatemeh
authors.forename: Mazaheri-Tehrani
authors.initials: MT
authors.lastname: Fahimeh
authors.forename: Zgholizadeh-Nasari
authors.initials: ZN
authors.lastname: Fatemeh
authors.forename: Behnam-Rassouli
authors.initials: BR
authors.lastname: Morteza
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002364:Caseins / Q000032:analysis*; D018592:Cross-Over Studies; D004032:Diet; D006937:Hypercholesterolemia / Q000178:diet therapy*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013025:Glycine max
chemical_list: D002364:Caseins