title: Thrombosis of the cerebral veins and sinuses in acute promyelocytic leukemia after all-trans retinoic acid treatment: a case report.
abstract: Thrombosis of the cerebral veins or sinuses is a rare cerebrovascular disorder, which seldom represents a complication of acute promyelocytic leukemia. To the best of our knowledge, it never occurred during treatment with all-trans retinoic acid. We report a case of a 35-year-old woman affected by acute promyelocytic leukemia, who developed massive thrombosis of the cerebral sinuses and veins when she was in complete morphological and molecular remission after all-trans retinoic acid and idarubicin treatment. Anticoagulant therapy contributed to progressive dissolution of the thrombosis as documented by magnetic resonance imaging with complete disappearance of neurological signs without sequelae.
authors.affiliation: Hematology Section, Department of Biomedical Sciences, University of Ferrara, Corso Giovecca 203, Ferrara, Italy. maria.ciccone@unife.it
authors.forename: Maria
authors.initials: M
authors.lastname: Ciccone
authors.forename: Gian Matteo
authors.initials: GM
authors.lastname: Rigolin
authors.forename: Giulia Marta
authors.initials: GM
authors.lastname: Viglione
authors.forename: Massimo
authors.initials: M
authors.lastname: Borrelli
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Serino
authors.forename: Antonio
authors.initials: A
authors.lastname: Cuneo
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D002543:Cerebral Hemorrhage / Q000139:chemically induced*; D005260:Female; D006801:Humans; D015255:Idarubicin / Q000008:administration & dosage; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy*; D012851:Sinus Thrombosis, Intracranial / Q000139:chemically induced*; D013927:Thrombosis / Q000139:chemically induced* / Q000517:prevention & control; D014212:Tretinoin / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D014212:Tretinoin; D015255:Idarubicin