title: Syntheses of the tedanolides.
abstract: This Highlight covers the synthetic contributions leading to the syntheses of tedanolide and 13-deoxytedanolide or the corresponding macrolactones, respectively. Additionally, the first SAR data for 13-deoxytedanolide (published by Fusetani) are presented.
authors.affiliation: Department of Chemistry and Biochemistry and the Walther Cancer Research Center, University of Notre Dame, Notre Dame, IN 46556-5670, USA. mroy2@nd.edu
authors.forename: Myriam
authors.initials: M
authors.lastname: Roy
authors.forename: Markus
authors.initials: M
authors.lastname: Kalesse
mesh_terms: D000818:Animals; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D048630:Polyketide Synthases / Q000378:metabolism; D011161:Porifera / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: C409106:13-deoxytedanolide; D018942:Macrolides; D048630:Polyketide Synthases; C119775:tedanolide