title: 5-Alkyl-2-ferrocenyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives inhibit growth of lung cancer A549 cell by inducing apoptosis.
abstract: we found that 5-alkyl-2-ferrocenyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives 8d, 8e and 8f could effectively induce apoptosis in A549 lung cancer cells and elevate the levels of integrin beta4 and ROS. The data suggested that these compounds might be promising agents for the cancer therapy, and these compounds would be useful tools for further investigate the functions of integrin beta4 in regulation of the cancer cell apoptosis.
authors.affiliation: Institute of Developmental Biology, School of Life Science, Shandong University, Jinan 250100, China.
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Pan
authors.forename: Xia
authors.initials: X
authors.lastname: Liu
authors.forename: Bao-Xiang
authors.initials: BX
authors.lastname: Zhao
authors.forename: Yong-Sheng
authors.initials: YS
authors.lastname: Xie
authors.forename: Dong-Soo
authors.initials: DS
authors.lastname: Shin
authors.forename: Shang-Li
authors.initials: SL
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.forename: Jun-Ying
authors.initials: JY
authors.lastname: Miao
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005296:Ferrous Compounds / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D039663:Integrin beta4 / Q000235:genetics / Q000378:metabolism; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D015394:Molecular Structure; D011719:Pyrazines / Q000737:chemistry* / Q000494:pharmacology*; D011720:Pyrazoles / Q000737:chemistry* / Q000494:pharmacology*; D034741:RNA, Small Interfering / Q000235:genetics; D017382:Reactive Oxygen Species / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D005296:Ferrous Compounds; D039663:Integrin beta4; D011719:Pyrazines; D011720:Pyrazoles; D034741:RNA, Small Interfering; D017382:Reactive Oxygen Species