Platelet function in hypertension.
Platelets from hypertensive patients show increased sensitivity to agonists and have high intracellular free Ca(2+) concentration. Furthermore, in hypertension, platelets show enhanced endogenous production of reactive oxygen species and a reduced antioxidant status which increases protein tyrosine phosphorylation, enhances Ca(2+) mobilization and attenuates NO bioavailability. The study of the abnormalities in platelet function in hypertensive patients can lead to the development of new pharmacological strategies to prevent and/or palliate hypertension-derived complications associated to platelet hyperactivity.
El Haouari
Mohammed
M
Département de Biologie, Université Mohamed 1(er), Faculté des Sciences, Oujda 60000, Morocco. elhouarim@yahoo.fr
Rosado
Juan A
JA
D015415:Biomarkers / Q000378:metabolism; D001792:Blood Platelets / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000209:etiology*; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology; D015539:Platelet Activation / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism
D015415:Biomarkers; D017382:Reactive Oxygen Species; D009569:Nitric Oxide; D002118:Calcium