title: Kidney growth in children with congenital hypothyroidism.
abstract: The effect of hypothyroidism on kidney size has not been studied in children. The aim of this study was to examine the role of congenital hypothyroidism and levothyroxine (L-thyroxine) treatment on renal growth. Forty children with congenital hypothyroidism and 37 healthy controls were prospectively included. The mean age of patients was 8.2+/-4.7 years. Patients had lower height and weight standard deviation scores compared with controls. The mean L-thyroxine initial age and treatment duration were 37.0 and 60.5 months, respectively. In 62.5% of patients, L-thyroxine was initiated after 6 months of age, and 60.0% of patients had severe hypothyroidism. Patients had lower kidney length and total kidney volume compared with controls (P < 0.05). No significant differences were found in kidney volume/body weight and kidney volume/ body height ratios between patients and controls (P > 0.05). Multiple regression analysis showed significant relationship between relative kidney volume and average free thyroxine level (P < 0.05). No significant differences in kidney sizes were found between patients who had L-thyroxine initiated before and after 6 months of age or between mild/moderate and severe hypothyroidism at diagnosis (P > 0.05). In conclusion, normal renal growth can be accomplished with L-thyroxine replacement despite considerable delay in treatment initiation and/or severe hypothyroidism.
authors.affiliation: Department of Pediatric Nephrology, Sami Ulus Children's Hospital, Ankara, Turkey. mbbjkank@hotmail.com
authors.forename: Mehmet
authors.initials: M
authors.lastname: Bülbül
authors.forename: Semra
authors.initials: S
authors.lastname: Cetinkaya
authors.forename: Seçil
authors.initials: S
authors.lastname: Ekşioğlu
authors.forename: Serdar
authors.initials: S
authors.lastname: Ozkasap
authors.forename: Tayfur
authors.initials: T
authors.lastname: Giniş
mesh_terms: D002648:Child; D002675:Child, Preschool; D003409:Congenital Hypothyroidism / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3; D018969:Insulin-Like Growth Factor Binding Proteins / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007668:Kidney / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000254:growth & development*; D008297:Male; D009929:Organ Size; D011446:Prospective Studies; D012044:Regression Analysis; D013963:Thyroid Hormones / Q000097:blood; D013974:Thyroxine / Q000008:administration & dosage*; D014463:Ultrasonography
chemical_list: C515497:IGFBP3 protein, human; D018972:Insulin-Like Growth Factor Binding Protein 3; D018969:Insulin-Like Growth Factor Binding Proteins; D013963:Thyroid Hormones; D007334:Insulin-Like Growth Factor I; D013974:Thyroxine