[Mitochondrial neuroprotection].
Mitochondria play a key function in cellular metabolism. Additionally to ATP synthesis, mitochondria may buffor cytosolic calcium ions and generate reactive oxygen species. Due to these processes, mitochondria are involved in complex cytoprotective phenomena. Neuroprotection is very often based on changes in the integrity of mitochondrial membranes. In this report potential neuroprotective role of mitochondrial ion channels is discussed.
Piwońska
Marta
M
Laboratory of Intracellular Ion Channels, Biochemistry Department, Nencki Institute of Experimental Biology, 3 Pasteur St., 02-093 Warsaw, Poland. m.glab@nencki.gov.pl
Szewczyk
Adam
A
D000818:Animals; D015220:Calcium Channels / Q000378:metabolism; D019610:Cytoprotection / Q000502:physiology*; D003600:Cytosol / Q000378:metabolism*; D006801:Humans; D007473:Ion Channels / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000378:metabolism; D015221:Potassium Channels / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D000071256:Uncoupling Protein 1
D015220:Calcium Channels; D007473:Ion Channels; D024101:Mitochondrial Proteins; D015221:Potassium Channels; D017382:Reactive Oxygen Species; D000071256:Uncoupling Protein 1