Endovascular intervention for acute thromboembolic stroke in young patients: an ideal population for aggressive intervention?
OBJECTIVE
Endovascular treatment of acute thromboembolic stroke is a rapidly developing field that appears to hold great promise. Young patients may be particularly suited to benefit from endovascular acute stroke therapy. The authors sought to identify outcomes in young patients with thromboembolic stroke who underwent endovascular intervention.


METHODS
The authors retrospectively reviewed a prospectively collected endovascular intervention registry of patients with ischemic strokes treated at a single large-volume institution between December 2000 and June 2007 to identify patients 18-35 years of age who were treated for thromboembolic stroke. Data are presented as the mean +/- standard deviation unless otherwise noted.


RESULTS
Seven young patients underwent 8 consecutive endovascular interventions for thromboembolic stroke (mean age 26 +/- 6 years; 5 women). The National Institutes of Health Stroke Scale score at presentation was 13 +/- 4.3 (median 13). All patients presented within 6 hours of symptom onset. Revascularization was attempted with mechanical thrombectomy/disruption, intraarterial thrombolysis, and/or angioplasty, with or without stent placement. The modified Rankin Scale (mRS) score at discharge was 2.2 +/- 1.5 (median 1.5), with 5 patients (62.5%) achieving independence at discharge (mRS Score 0-2). There were no deaths. Hospital length of stay was 6.5 +/- 3.7 days (4.4 +/- 1.5 days for patients with an mRS score of 0-2; 10 +/- 3.6 days for patients with an mRS score of 4). All patients became independent and had reached an mRS score of < or = 2 at last follow-up evaluation (29 +/- 25 months).


CONCLUSIONS
The data demonstrate the relative safety of endovascular intervention in young patients with thromboembolic cerebral ischemia and may suggest a potential benefit in outcome. Further investigation is indicated with larger numbers of patients and an appropriate control population.
Mocco
J
J
Department of Neurosurgery and Toshiba Stroke Research Center, University at Buffalo, State University of New York , USA, New York.
Tawk
Rabih G
RG
Jahromi
Babak S
BS
Samuelson
Rodney M
RM
Siddiqui
Adnan H
AH
Hopkins
L Nelson
LN
Levy
Elad I
EI
D000293:Adolescent; D000328:Adult; D017130:Angioplasty; D002341:Carotid Artery Thrombosis / Q000000981:diagnostic imaging / Q000601:surgery; D002548:Cerebral Revascularization; D005260:Female; D006801:Humans; D020766:Intracranial Embolism / Q000150:complications* / Q000601:surgery*; D007431:Intraoperative Complications / Q000628:therapy; D008297:Male; D012189:Retrospective Studies; D020521:Stroke / Q000209:etiology* / Q000601:surgery*; D017131:Thrombectomy; D015912:Thrombolytic Therapy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult