title: The DRD2 gene 957C>T polymorphism is associated with posttraumatic stress disorder in war veterans.
abstract: BACKGROUND
  Variations in genes related to the dopaminergic pathway have been implicated in neuropsychiatric disorders such as schizophrenia, substance misuse, Alzheimer's disease and Post Traumatic Stress Disorder (PTSD). A single nucleotide polymorphism (SNP) (957C>T) and a deletion polymorphism (-141delC) in the DRD2 gene and a SNP (Taq1A) in a gene directly downstream of DRD2 have all been implicated in dopamine functioning in the brain.
  
  
  METHODS
  To test the importance of these three polymorphisms in PTSD susceptibility, a genetic screen was performed in 127 war veterans diagnosed with PTSD and 228 control individuals without a history of PTSD.
  
  
  RESULTS
  No significant association was found between PTSD and the Taq1A or -141delC polymorphisms. However, a significant association was observed with PTSD and the 957C>T polymorphism. PTSD individuals were more likely to carry the C allele compared to the controls (P=0.021).
  
  
  CONCLUSIONS
  Our findings suggest that the 957C>T polymorphism in the DRD2 gene is one of the genetic factors for susceptibility to PTSD.
authors.affiliation: Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia. j.voisey@qut.edu.au
authors.forename: Joanne
authors.initials: J
authors.lastname: Voisey
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Swagell
authors.forename: Ian P
authors.initials: IP
authors.lastname: Hughes
authors.forename: C Phillip
authors.initials: CP
authors.lastname: Morris
authors.forename: Angela
authors.initials: A
authors.lastname: van Daal
authors.forename: Earnest P
authors.initials: EP
authors.lastname: Noble
authors.forename: Burnett
authors.initials: B
authors.lastname: Kann
authors.forename: Karen A
authors.initials: KA
authors.lastname: Heslop
authors.forename: Ross McD
authors.initials: RM
authors.lastname: Young
authors.forename: Bruce R
authors.initials: BR
authors.lastname: Lawford
mesh_terms: D000328:Adult; D000483:Alleles; D001315:Australia; D003130:Combat Disorders / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D008297:Male; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D014728:Veterans / Q000523:psychology*; D047829:Vietnam Conflict
chemical_list: D017448:Receptors, Dopamine D2