Investigation of diffuse correlation spectroscopy in multi-layered media including the human head.
In this work, diffuse correlation spectroscopy (DCS) is explored in multi-layered geometries. A quantitative comparison of an homogeneous versus a two-layered model efficiencies to recover flow changes is presented. By simulating a realistic human head with MRI anatomical data, we show that the two-layered model allows distinction between changes in superficial layers and brain. We also show that the two-layered model provides a better estimate of the flow change than the homogeneous one. Experimental measurements with a two-layered dynamical phantom confirm the ability of the two-layered analytical model to distinguish flow increase in each layer.
Gagnon
Louis
L
Institut de génie biomédical, Ecole Polytechnique de Montréal, C.P. 6079, succ. Centre-Ville, Montréal, Qc, H3C 3A7, Canada. louis-2.gagnon@polymtl.ca
Desjardins
Michèle
M
Jehanne-Lacasse
Julien
J
Bherer
Louis
L
Lesage
Frédéric
F
D001921:Brain / Q000033:anatomy & histology / Q000473:pathology; D002560:Cerebrovascular Circulation; D003198:Computer Simulation; D004058:Diffusion; D006257:Head / Q000033:anatomy & histology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D055095:Optics and Photonics; D019047:Phantoms, Imaging; D017785:Photons; D013053:Spectrophotometry / Q000379:methods; D013057:Spectrum Analysis / Q000379:methods*