title: Pediatric squamous cell carcinoma arising in an alpha-fetoprotein-producing mature cystic teratoma of the mandible.
abstract: Teratomas, most often diagnosed in younger patients, represent the most frequently identified subtype of pediatric germ cell tumors. It is very uncommon for teratomas to present in the head and neck region and demonstrate malignant transformation. We present a case of squamous cell carcinoma arising in an alpha-fetoprotein-producing cystic teratoma of the mandible in a 2-year-old female that is, to the best of our knowledge, the first such published report. The patient was treated with surgical excision along with chemotherapy and has remained disease-free 2 years after the conclusion of therapy.
authors.affiliation: Department of Pathology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60153, USA. rcabay@lumc.edu
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Cabay
authors.forename: Suman
authors.initials: S
authors.lastname: Setty
authors.forename: Joel L
authors.initials: JL
authors.lastname: Schwartz
authors.forename: Mike
authors.initials: M
authors.lastname: Yao
authors.forename: Mary Lou
authors.initials: ML
authors.lastname: Schmidt
authors.forename: Sara C
authors.initials: SC
authors.lastname: Gordon
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000628:therapy; D002471:Cell Transformation, Neoplastic; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008339:Mandibular Neoplasms; D013724:Teratoma / Q000473:pathology*; D000509:alpha-Fetoproteins
chemical_list: D000509:alpha-Fetoproteins