title: Metabolic syndrome is associated with erosive esophagitis.
abstract: OBJECTIVE
  To clarify whether insulin resistance and metabolic syndrome are risk factors for erosive esophagitis.
  
  
  METHODS
  A case-control study was performed using the database of the Kangbuk Samsung Hospital Medical Screening Center.
  
  
  RESULTS
  A total of 1679 cases of erosive esophagitis and 3358 randomly selected controls were included. Metabolic syndrome was diagnosed in 21% of the cases and 12% of the controls (P < 0.001). Multiple logistic regressions confirmed the association between erosive esophagitis and metabolic syndrome (Odds ratio, 1.25; 95% CI, 1.04-1.49). Among the components of metabolic syndrome, increased waist circumference, elevated serum triglyceride levels and hypertension were significant risk factors for erosive esophagitis (all P < 0.01). Furthermore, increased insulin resistance (Odds ratio, 0.91; 95% CI, 0.85-0.98) and fatty liver, as diagnosed by ultrasonography (Odds ratio, 1.39; 95% CI, 1.20-1.60), were also related to erosive esophagitis even after adjustment for a series of confounding factors.
  
  
  CONCLUSIONS
  Metabolic syndrome and increased insulin resistance are associated with an increased risk of developing erosive esophagitis.
authors.affiliation: Department of Medicine, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, South Korea. pjho3@hotmail.com
authors.forename: Jung-Ho
authors.initials: JH
authors.lastname: Park
authors.forename: Dong-Il
authors.initials: DI
authors.lastname: Park
authors.forename: Hong-Joo
authors.initials: HJ
authors.lastname: Kim
authors.forename: Yong-Kyun
authors.initials: YK
authors.lastname: Cho
authors.forename: Chong-Il
authors.initials: CI
authors.lastname: Sohn
authors.forename: Woo-Kyu
authors.initials: WK
authors.lastname: Jeon
authors.forename: Byung-Ik
authors.initials: BI
authors.lastname: Kim
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004941:Esophagitis / Q000209:etiology* / Q000473:pathology; D005260:Female; D005764:Gastroesophageal Reflux / Q000209:etiology; D006801:Humans; D007333:Insulin Resistance; D007723:Korea; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications*; D008875:Middle Aged; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides