Antioxidant and hepatoprotective activity of tubers of Momordica tuberosa Cogn. against CCl4 induced liver injury in rats.
Hydro alcoholic extract of tubers of M. tuberosa was subjected to preliminary phytochemical screening and evaluated for in vitro and in vivo antioxidant and hepatoprotective activity against CCl4 induced liver damage in rats. Pretreatment with 70% ethanolic extract of M. tuberosa reversed CCl4 induced elevation of levels of serum biomarkers to near normal levels, suggesting that the tubers of M. tuberosa possess hepatoprotective property and this property may be attributed to the antioxidant property of the plant.
Pramod
Kumar
K
Department of Pharmacognosy, V.L. College of Pharmacy, Raichur, 584 103, India. pramod4407@gmail.com
Deval
Rao G
RG
Lakshmayya
Ramachandra
Setty S
SS
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D002251:Carbon Tetrachloride / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D005978:Glutathione / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000293:injuries* / Q000378:metabolism; D008297:Male; D051379:Mice; D029775:Momordica / Q000737:chemistry*; D008517:Phytotherapy; D018517:Plant Roots / Q000737:chemistry*; D051381:Rats
D000975:Antioxidants; D002251:Carbon Tetrachloride; D005978:Glutathione