Inhibition of Candida albicans isocitrate lyase activity by sesterterpene sulfates from the tropical sponge Dysidea sp.
Seven sesterterpene sulfates (1-7) were isolated from the tropical sponge Dysidea sp. and their inhibitory activities against isocitrate lyase (ICL) from Candida albicans were evaluated. Among the isolated natural products compound 6 and 7 were found to be strong ICL inhibitors. The isolated compounds (1-7) also showed potent antibacterial effect against Bacillus subtilis and Proteus vulgaris, but did not display antifungal activity.
Lee
Dongha
D
Natural Products Research Institute, College of Pharmacy, Seoul National University, 599 Gwanangno, Gwanak-ku, Seoul 151-742, Republic of Korea.
Shin
Jongheon
J
Yoon
Kyung-Mi
KM
Kim
Tae-Im
TI
Lee
So-Hyoung
SH
Lee
Hyi-Seung
HS
Oh
Ki-Bong
KB
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001412:Bacillus subtilis / Q000378:metabolism; D001681:Biological Assay / Q000379:methods; D002176:Candida albicans / Q000201:enzymology*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D047088:Dysidea; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D007522:Isocitrate Lyase / Q000037:antagonists & inhibitors* / Q000737:chemistry; D011514:Proteus vulgaris / Q000378:metabolism; D054830:Sesterterpenes / Q000737:chemistry*; D013431:Sulfates / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D004791:Enzyme Inhibitors; D054830:Sesterterpenes; D013431:Sulfates; D007522:Isocitrate Lyase