title: PID: the Pathway Interaction Database.
abstract: The Pathway Interaction Database (PID, http://pid.nci.nih.gov) is a freely available collection of curated and peer-reviewed pathways composed of human molecular signaling and regulatory events and key cellular processes. Created in a collaboration between the US National Cancer Institute and Nature Publishing Group, the database serves as a research tool for the cancer research community and others interested in cellular pathways, such as neuroscientists, developmental biologists and immunologists. PID offers a range of search features to facilitate pathway exploration. Users can browse the predefined set of pathways or create interaction network maps centered on a single molecule or cellular process of interest. In addition, the batch query tool allows users to upload long list(s) of molecules, such as those derived from microarray experiments, and either overlay these molecules onto predefined pathways or visualize the complete molecular connectivity map. Users can also download molecule lists, citation lists and complete database content in extensible markup language (XML) and Biological Pathways Exchange (BioPAX) Level 2 format. The database is updated with new pathway content every month and supplemented by specially commissioned articles on the practical uses of other relevant online tools.
authors.affiliation: National Cancer Institute, Center for Biomedical Informatics and Information Technology, Rockville MD, USA. schaefec@mail.nih.gov
authors.forename: Carl F
authors.initials: CF
authors.lastname: Schaefer
authors.forename: Kira
authors.initials: K
authors.lastname: Anthony
authors.forename: Shiva
authors.initials: S
authors.lastname: Krupa
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Buchoff
authors.forename: Matthew
authors.initials: M
authors.lastname: Day
authors.forename: Timo
authors.initials: T
authors.lastname: Hannay
authors.forename: Kenneth H
authors.initials: KH
authors.lastname: Buetow
mesh_terms: D001692:Biological Transport; D002468:Cell Physiological Phenomena; D016208:Databases, Factual; D005786:Gene Expression Regulation; D006801:Humans; D020407:Internet; D025941:Protein Interaction Mapping; D011506:Proteins / Q000737:chemistry / Q000378:metabolism; D012313:RNA / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction; D014584:User-Computer Interface
chemical_list: D011506:Proteins; D012313:RNA