title: [Classification of prosthetic loosening and determination of wear particles].
abstract: Nowaday, loosening of orthopaedic implants implies important medical and socioeconomic problems. Implant loosening is caused by implant infections as well as aseptic loosening, due to particle disease and mechanical alterations. Clinically we divide the implant infection into early and late infections. Morphologically it is possible to reliably detect the infection by quantification of neutrophil granulocytes. Additionally molecular methods are suitable to detect micro-organisms which are responsible for the prosthetic joint infection including their resistance to antibiotics. Particle disease may be reproducibly classified by the detection of different types of wear particles, particularly polyethylene, metal, ceramic and cement. The aetiology of the indeterminate type of the periprosthetic membrane is obscure, but may be associated with osteopathies. This classification of the periprosthetic membrane morphology provides clinically significant information concerning clinical management of implant loosening.
authors.affiliation: Zentrum für Histologie, Zytologie und Molekulare Diagnostik Trier, Molekularpathologie Trier, Max-Planck-Strasse 18+20, 54296 Trier. otto@patho-trier.de
authors.forename: M
authors.initials: M
authors.lastname: Otto
mesh_terms: D001672:Biocompatible Materials / Q000009:adverse effects*; D018441:Biofilms; D019544:Equipment Failure Analysis; D005549:Foreign-Body Reaction / Q000473:pathology*; D006801:Humans; D007595:Joint Prosthesis; D007596:Joints / Q000473:pathology; D010316:Particle Size; D016459:Prosthesis-Related Infections / Q000473:pathology*; D012307:Risk Factors
chemical_list: D001672:Biocompatible Materials