Gene expression profiling of liver metastases from colorectal cancer as potential basis for treatment choice.
At present no reports on gene expression profiling of liver metastases from colorectal cancer are available. We identified two different signatures using Affymetrix platform: epidermal growth factor receptor pathway was upregulated in metachronous lesions, whereas the pathway mainly related to angiogenesis was in synchronous lesions. Synchronous or metachronous liver metastases could be treated differently on the basis of different molecular pathways.
Pantaleo
M A
MA
Institute of Hematology and Medical Oncology LA Seragnoli, S Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Astolfi
A
A
Nannini
M
M
Paterini
P
P
Piazzi
G
G
Ercolani
G
G
Brandi
G
G
Martinelli
G
G
Pession
A
A
Pinna
A D
AD
Biasco
G
G
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D066246:ErbB Receptors / Q000235:genetics; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000235:genetics; D016609:Neoplasms, Second Primary / Q000235:genetics
D014408:Biomarkers, Tumor; D066246:ErbB Receptors