Relationship between susceptibility of Candida spp. isolates to amphotericin B and death or survival of patients with candidemia episodes.
In this study, the susceptibility to amphotericin B of Candida spp. isolates obtained from patients with candidemia was related to their respective clinical outcomes. The susceptibility tests were carried out in three culture media: RPMI 1640, Antibiotic medium 3 and Yeast Nitrogen Base dextrose. We have found that minimal inhibitory concentrations and minimal fungicidal concentrations obtained using AM3 and YNBd media were significantly higher for Candida spp. from patients who died than for those from patients who survived the candidemia (P < 0.05). The assays with RPMI 1640 medium did not show these differences.
Alves
Sydney Hartz
SH
Department of Microbiology and Parasitology, Universidade Federal de Santa Maria, Rua dos Andradas 1985/201, Santa Maria, RS, Brazil. hartzsa@smail.ufsm.br
Boff
Everton
E
Pozzatti
Patricia
P
Scheid
Liliane A
LA
de Loreto
Erico
E
Ottoneli Oliveira
Loiva T
LT
Aquino
Valério
V
Severo
Luiz Carlos
LC
Santurio
Janio Morais
JM
D000666:Amphotericin B / Q000494:pharmacology* / Q000627:therapeutic use; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002175:Candida / Q000187:drug effects*; D002177:Candidiasis / Q000382:microbiology / Q000401:mortality / Q000628:therapy; D003470:Culture Media; D025141:Drug Resistance, Fungal; D006801:Humans; D008826:Microbial Sensitivity Tests; D016896:Treatment Outcome
D000935:Antifungal Agents; D003470:Culture Media; D000666:Amphotericin B