B-alkyl Suzuki couplings for the stereoselective synthesis of substituted pyrans.
Unprotected homoallylic alcohols can be directly converted to cis-2,6-disubstituted pyrans by palladium catalyzed B-alkyl Suzuki coupling and subsequent Michael addition.
O'Neil
Gregory W
GW
Max-Planck-Institut für Kohlenforschung, D-45470, Mülheim/Ruhr, Germany.
Fürstner
Alois
A
D002384:Catalysis; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D020005:Propanols / Q000737:chemistry*; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D020005:Propanols; D011714:Pyrans; C006463:allyl alcohol; D010165:Palladium