Microimaging FTIR of head and neck tumors. IV.
On continuing our studies on head and neck neoplasia, specimens from salivary gland tumors have been explored by using infrared microimaging spectroscopy to discern healthy from neoplastic tissues. Samples with Warthin tumor, epithelial displasia, marginal B-cell lymphoma, low-grade adenocarcinoma, and adenoid cystic carcinoma pathologies have been investigated by using conventional light sources. Changes were monitored at the molecular level, probing spectral markers such as Amide I and II, phosphate, nucleic acids, and carbohydrates vibrational modes. In all cases, supervised and unsupervised spectral analyses resulted in satisfactory agreement with histopathological findings.
Conti
Carla
C
Dipartimento di Scienze e Tecnologie Chimiche, Università Politecnica delle Marche, Ancona, Italy.
Ferraris
Paolo
P
Garavaglia
Maria
M
Giorgini
Elisabetta
E
Rubini
Corrado
C
Sabbatini
Simona
S
Tosi
Giorgio
G
D014408:Biomarkers, Tumor / Q000032:analysis; D016000:Cluster Analysis; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D016011:Normal Distribution; D010363:Pattern Recognition, Automated / Q000379:methods*; D025341:Principal Component Analysis; D012468:Salivary Gland Neoplasms / Q000737:chemistry / Q000473:pathology*; D012469:Salivary Glands / Q000737:chemistry / Q000473:pathology; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*
D014408:Biomarkers, Tumor