Prospective follow-up oral food challenge in food protein-induced enterocolitis syndrome.
OBJECTIVE
To determine tolerance rates to cow's milk and soy and to suggest guidelines for follow-up oral food challenges (FU-OFCs) in infantile food protein-induced enterocolitis syndrome (FPIES).


METHODS
The authors analysed the data of 23 patients with infantile FPIES who underwent two or more FU-OFCs and were followed up until over 2 years of age. The first FU-OFCs were performed at 6 months of age, and patients were randomly allocated to cow's milk (n = 11) or soy (n = 12) challenge starting groups. Second and third FU-OFCs were performed at 2-month intervals in a crossed and switched-over manner.


RESULTS
Tolerance rates to cow's milk and soy were 27.3% and 75.0% at 6 months of age, 41.7% and 90.9% at 8 months and 63.6% and 91.7% at 10 months, respectively. Patients outgrew cow's milk and soy intolerance at age 20 and 14 months.


CONCLUSIONS
In infantile FPIES, the first FU-OFC should be performed with soy at 6-8 months of age and cow's milk FU-OFC should be conducted at over 12 months of age. Infants with FPIES were observed to outgrow food sensitivities during the first 2 years of life.
Hwang
J-B
JB
Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Republic of Korea. pedgi@kmu.ac.kr
Sohn
S M
SM
Kim
A S
AS
D000284:Administration, Oral; D004760:Enterocolitis / Q000209:etiology* / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007223:Infant; D008297:Male; D008894:Milk Proteins / Q000009:adverse effects* / Q000276:immunology; D017410:Practice Guidelines as Topic; D011446:Prospective Studies; D030262:Soybean Proteins / Q000009:adverse effects* / Q000276:immunology; D013577:Syndrome; D013997:Time Factors
D008894:Milk Proteins; D030262:Soybean Proteins; D007073:Immunoglobulin E