Autoadjusting-CPAP effect on serum leptin concentrations in obstructive sleep apnoea patients.
BACKGROUND
Leptin is an hormone that regulates body weight. Studies have shown increasing leptin concentrations according to body mass index (BMI) and intermittent hypoxia. Our aim is to evaluate the basal leptin levels in OSA patients and its possible relation to OSA severity, independently of confounders and investigate the Autoadjusting-CPAP effect on leptin values.


METHODS
In ninety eight male patients with moderate to severe OSA leptin serum levels were evaluated before therapy, 9 days and 6 months after therapy.


RESULTS
In this group mean age was 55.3 years, mean BMI was 33.2 Kg/m2 and mean Apnoea- Hypopnea Index (AHI) was 51.7/h. Mean basal serum leptin value was 12.1 ug/L. Univariate analysis showed a significant correlation between serum leptin values and BMI (R = 0.68; p < 0.001), waist-hip ratio (R = 0.283; p = 0.004) and AHI (R = 0.198; p = 0.048); in stepwise multiple regression analysis only BMI (p < 0.001) was a predictor of serum leptin values. One week after therapy, mean leptin serum level decreased to 11.0 ug/L and 6 months after it was 11.4 ug/L. (p = 0.56 and p = 0.387, respectively)


CONCLUSIONS
Baseline leptin serum levels positively correlate with BMI, fat distributio and OSA severity. BMI is the only predictor of basal leptin levels.Treatment with Autoadjusting-CPAP has a small effect on leptin levels.
Drummond
Marta
M
Pulmonology Department, Hospital de São João, Alameda Hernâni Monteiro, 4200-319 Porto, Portugal. marta.drummond@gmail.com
Winck
João C
JC
Guimarães
João T
JT
Santos
Ana C
AC
Almeida
João
J
Marques
José A
JA
D000368:Aged; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D045422:Continuous Positive Airway Pressure; D005500:Follow-Up Studies; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood; D011446:Prospective Studies; D012044:Regression Analysis; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000628:therapy*
D020738:Leptin