Association of a single-nucleotide polymorphism in the pregnane X receptor (PXR 63396C-->T) with reduced concentrations of unboosted atazanavir.
This study investigated pregnane X receptor polymorphisms in relation to unboosted atazanavir plasma concentrations in 2 cohorts of patients. The polymorphism 63396T-->C predicted concentrations below the minimum effective concentration (150 ng/mL) with odds ratios of 18 (P = .008) and 5.13 (P = .02). Prospective studies determining potential clinical usefulness are now warranted.
Siccardi
Marco
M
Department of Infectious Diseases, University of Turin, Amedeo di Savoia Hospital, Turin, Italy.
D'Avolio
Antonio
A
Baietto
Lorena
L
Gibbons
Sara
S
Sciandra
Mauro
M
Colucci
Daniela
D
Bonora
Stefano
S
Khoo
Saye
S
Back
David J
DJ
Di Perri
Giovanni
G
Owen
Andrew
A
D000328:Adult; D000069446:Atazanavir Sulfate; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy / Q000235:genetics; D017320:HIV Protease Inhibitors / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009842:Oligopeptides / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D020641:Polymorphism, Single Nucleotide; D000077297:Pregnane X Receptor; D011725:Pyridines / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D011987:Receptors, Steroid / Q000235:genetics* / Q000378:metabolism
D017320:HIV Protease Inhibitors; D009842:Oligopeptides; D000077297:Pregnane X Receptor; D011725:Pyridines; D011987:Receptors, Steroid; D000069446:Atazanavir Sulfate