Macrolide myths.
In spite of decades of research, our knowledge of the mode of interaction of macrolide antibiotics with their ribosomal target and of the mechanism of action of these drugs remain fragmentary. Experimental facts obtained over the past several years question some of the concepts that were viewed as a 'common knowledge'. This review focuses on certain aspects of binding and action of macrolides that may need re-evaluation in view of the new findings.
Mankin
Alexander S
AS
Center for Pharmaceutical Biotechnology-m/c 870, University of Illinois at Chicago, 900 S. Ashland Avenue, Room 3052, Chicago, IL 60607, USA. shura@uic.edu
D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D018942:Macrolides / Q000378:metabolism / Q000494:pharmacology*; D008958:Models, Molecular; D015394:Molecular Structure; D014176:Protein Biosynthesis / Q000187:drug effects*; D012270:Ribosomes / Q000187:drug effects* / Q000378:metabolism
D000900:Anti-Bacterial Agents; D018942:Macrolides