title: Frailty and its potential relevance to cardiovascular care.
abstract: Frailty is characterized by vulnerability to acute stressors and is a consequence of decline in overall function and physiologic reserves. An estimated 7% of the US population older than 65 years and 30% of octogenarians are frail. The domains to define frailty include mobility, strength, balance, motor processing, cognition, nutrition, endurance, and physical activity. Pathophysiologic pathways leading to frailty involve a multisystem cascade that includes neuroendocrine dysfunction with lower insulin-like growth factor and dehydroepiandrosterone sulfate and an altered inflammatory milieu with increased levels of C-reactive protein, interleukins, tumor necrosis factor alpha, and abnormal coagulation. Frailty predicts death and heralds the transition to disability in general populations. As the population with coronary artery disease shifts toward older patients, physicians must consider the role of frailty in their patients. This review will enable clinicians to recognize frailty and consider its relevance in their daily practice. We also elaborate on reasons to consider frailty in older adults with cardiovascular disease and focus on its early identification, on referral to specialists, and on care after serious cardiac events.
authors.affiliation: Division of Cardiovascular Diseases, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA. singh.mandeep@mayo.edu
authors.forename: Mandeep
authors.initials: M
authors.lastname: Singh
authors.forename: Karen
authors.initials: K
authors.lastname: Alexander
authors.forename: Veronique L
authors.initials: VL
authors.lastname: Roger
authors.forename: Charanjit S
authors.initials: CS
authors.lastname: Rihal
authors.forename: Heather E
authors.initials: HE
authors.lastname: Whitson
authors.forename: Amir
authors.initials: A
authors.lastname: Lerman
authors.forename: Arschad
authors.initials: A
authors.lastname: Jahangir
authors.forename: K Sreekumaran
authors.initials: KS
authors.lastname: Nair
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000628:therapy*; D016330:Frail Elderly; D014943:Global Health; D006299:Health Services for the Aged / Q000592:standards*; D006801:Humans; D009017:Morbidity; D011379:Prognosis