title: Toxic epidermal necrolysis induced by sulfonamide eyedrops.
abstract: OBJECTIVE
  To describe a case of toxic epidermal necrolysis (TEN) triggered by sulfonamide eyedrops.
  
  
  METHODS
  A 9-year-old white boy with type I diabetes developed fever, constitutional symptoms, and a widespread blistering rash within hours of beginning a course of sulfonamide eyedrops for conjunctivitis. The patient was intubated and treated with broad-spectrum antibiotics and systemic and topical corticosteroids.
  
  
  RESULTS
  The patient survived and has bilateral acuities of 20/30 at 12 months of follow-up. Pathological examination of a skin biopsy sample confirmed the diagnosis of TEN.
  
  
  CONCLUSIONS
  TEN is a rare but life-threatening side effect of topical sulfonamide eyedrops.
authors.affiliation: Edward Harkness Eye Institute, Columbia University, College of Physicians and Surgeons, New York, NY 10032 , USA. h_f_fine@yahoo.com
authors.forename: Howard F
authors.initials: HF
authors.lastname: Fine
authors.forename: Esther
authors.initials: E
authors.lastname: Kim
authors.forename: Kenneth D
authors.initials: KD
authors.lastname: Eichenbaum
authors.forename: Kristina
authors.initials: K
authors.lastname: Antoniades
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Williams
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001706:Biopsy; D002648:Child; D003231:Conjunctivitis / Q000150:complications / Q000188:drug therapy; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D005500:Follow-Up Studies; D006801:Humans; D007440:Intubation; D008297:Male; D009883:Ophthalmic Solutions; D012867:Skin / Q000473:pathology; D013262:Stevens-Johnson Syndrome / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D013449:Sulfonamides / Q000008:administration & dosage* / Q000009:adverse effects* / Q000627:therapeutic use; D014792:Visual Acuity
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D009883:Ophthalmic Solutions; D013449:Sulfonamides