Total synthesis of amphidinolide J.
The marine natural product amphidinolide J has been synthesized according to a convergent strategy. The key steps of this synthesis include a B-alkyl Suzuki-Miyaura coupling and the addition of an alkynyllithium reagent to a Weinreb amide to build the C4-C5 and C12-C13 bonds, respectively, and a Yamaguchi macrolactonization.
Barbazanges
Marion
M
Laboratoire de Chimie Organique, ESPCI ParisTech, CNRS, 10 rue Vauquelin, 75231 Paris Cedex 05, France.
Meyer
Christophe
C
Cossy
Janine
J
D002244:Carbon / Q000737:chemistry; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D000097442:Amphidinolides
D002244:Carbon; D018942:Macrolides; C533296:amphidinolide J; D000097442:Amphidinolides