title: Plexiform angiomyxoid myofibroblastic tumour: differential diagnosis of gastrointestinal stromal tumour in the stomach.
abstract: Mesenchymal tumours other than gastrointestinal stromal tumours are rare in the stomach. Nevertheless it is important to incorporate them into the differential diagnosis. Plexiform angiomyxoid myofibroblastic tumour is a recently described new entity of a presumably benign mesenchymal gastric tumour. This report presents what is believed to be the third case of this tumour. The tumour is characterised by bland spindle cells in a plexiform pattern, a mucinous extracellular matrix and a network of thin blood vessels. These findings are completely in line with the two previous reported cases. There was a strong positivity for alpha-smooth muscle actin and a low proliferation index (<2%). The tumour had no C-KIT or CD34 expression and no mutation in the C-KIT and PDFGRalpha genes. Plexiform angiomyxoid myofibroblastic tumour may present a new mesenchymal tumour entity in the stomach.
authors.affiliation: Institute of Pathology, University Hospital Erlangen, Erlangen, Germany. Rau@uk-erlangen.de
authors.forename: T T
authors.initials: TT
authors.lastname: Rau
authors.forename: A
authors.initials: A
authors.lastname: Hartmann
authors.forename: W
authors.initials: W
authors.lastname: Dietmaier
authors.forename: J
authors.initials: J
authors.lastname: Schmitz
authors.forename: W
authors.initials: W
authors.lastname: Hohenberger
authors.forename: F
authors.initials: F
authors.lastname: Hofstaedter
authors.forename: K
authors.initials: K
authors.lastname: Katenkamp
mesh_terms: D004252:DNA Mutational Analysis; D003937:Diagnosis, Differential; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008637:Mesenchymoma / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D047708:Myofibroma / Q000473:pathology; D009232:Myxoma / Q000473:pathology; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery