Effect of age and gender in the pharmacokinetics of albendazole and albendazole sulphoxide enantiomers in goats.
The kinetics of albendazole metabolites and albendazole sulphoxide enantiomers were studied in 2- and 14-month-old female and male goats, after a single oral dose administration (10mg/kg) of an albendazole formulation. Blood samples from the jugular vein were collected at 0.5, 1, 2, 4, 6, 8, 10, 12, 16, 20, 24, 30, 36, 42, 48 and 54h post-treatment and analyzed using a high performance liquid chromatography method. In all groups the area under the plasma concentration-time curve (AUC) and peak concentration (C(max)) values of (+)-ABZSO were significantly higher than those of (-)-ABZSO. The AUC and C(max) values obtained for (+)-ABZSO and (-)-ABZSO in adult animals were higher compared to the results in young animals, showing significant differences except for (+)-ABZSO in female animals. In young animals, independently of gender, the C(max) appeared earlier compared to adult animals. The mean residence time (MRT) values were shorter in young animals compared to adult animals for all compounds analyzed. No sex-related differences were found for any of the parameters calculated except for the (+)-ABZSO from adult animals.
Capece
B P S
BP
Secção de Farmacologia e Toxicologia, Departamento de Para-Clínicas, Faculdade de Veterinária, Universidade Eduardo Mondlane, Av. de Moçambique, Km 1,5, Maputo, Mozambique. bpscapece@yahoo.com
Afonso
S M S
SM
Lazáro
R
R
Harun
M
M
Godoy
C
C
Castells
G
G
Cristòfol
C
C
D000375:Aging / Q000502:physiology*; D015766:Albendazole / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D000871:Anthelmintics / Q000097:blood / Q000493:pharmacokinetics; D000981:Antiprotozoal Agents / Q000097:blood / Q000493:pharmacokinetics; D005260:Female; D006041:Goats / Q000378:metabolism*; D008297:Male; D012044:Regression Analysis; D012727:Sex Characteristics
D000871:Anthelmintics; D000981:Antiprotozoal Agents; D015766:Albendazole; C027186:albendazole sulfoxide