[Radiobiological analysis of cancerogenic risk values in radioepidemiological investigations].
The aim of the present article consisted in critical analysis of the epidemiological approach to radiocancerogenic risk estimation in region of low level radiation (LLR). The estimation is making by means of mathematician models that ignore a principal difference in biological action of LLR and high level radiation (HLR). The main formal characteristic of LLR action is the presence of a plateau in beginning of a dose-effect curve of radiogenic risk. It may be argued by the following positions: repeating the plateau-phenomenon on various radiobiological effects, in different tests and bioobjects, first; a paradoxical trend of reciprocal ERR/Sv increasing regarding dose decreasing in region of plateau, second, and third, the increasing of the curvature in dose-effect curve beginning. The presence of a plateau is associated with the presence of a real radiogenic risk threshold. Besides, the analysis of processes influencing significantly the dynamics of initial radiation injury of biologically important macromolecules showed the preference in region of LLR those, decreasing/eliminating genome damages. There is follows from mentioned above a necessity to evaluate radiogenic risks in LLR region separately from HLR region.
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D015331:Cohort Studies; D004249:DNA Damage; D003627:Data Interpretation, Statistical; D004307:Dose-Response Relationship, Radiation; D015894:Genome, Human / Q000528:radiation effects; D006801:Humans; D008954:Models, Biological; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology* / Q000401:mortality; D011839:Radiation, Ionizing; D018788:Radioactive Hazard Release; D018570:Risk Assessment; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology