title: Angiogenic non-Hodgkin T/natural killer (NK)-cell lymphoma: report of three cases.
abstract: Angiogenic T/natural killer (NK)-cell lymphoma is a non-Hodgkin lymphoma characterized by necrosis and vascular destruction that is strongly associated with Epstein-Barr virus and AIDS. Early diagnosis is essential to improve the chances of patient survival, but severe local inflammatory infiltrate impairs histologic diagnosis by obscuring neoplastic cells. The most common markers are CD2, CD56, cytoplasmic CD3, and CD43 EBV. We describe 3 cases of angiogenic T/NK-cell lymphoma that show the diverse presentation of the same disease. Patient 1 was HIV positive and had nasal obstruction, facial edema, and ulceration of the nasal mucosa. Patient 2 had fever, a sore throat, and weight loss. Patient 3 had facial edema, fever, proptosis, and rapid development of neurologic alterations. Several biopsies were needed for histologic confirmation in these patients, despite positivity for the CD3 and CD56 markers.
authors.affiliation: Department of Ophthalmology, Otorhinolaryngology, and Head and Neck Surgery, Faculty of Medicine of Ribeirão Preto, Av. Bandeirantes, Ribeirão Preto, SP, Brazil.
authors.forename: Rubens A
authors.initials: RA
authors.lastname: Martins-Filho
authors.forename: Ricardo C
authors.initials: RC
authors.lastname: Demarco
authors.forename: Fabiana C
authors.initials: FC
authors.lastname: Valera
authors.forename: Catarina
authors.initials: C
authors.lastname: Shaletich
authors.forename: Paulo R
authors.initials: PR
authors.lastname: Félix
authors.forename: Giovana B
authors.initials: GB
authors.lastname: Badiale
authors.forename: Wilma T
authors.initials: WT
authors.lastname: Anselmo-Lima
mesh_terms: D017252:CD3 Complex / Q000032:analysis; D019002:CD56 Antigen / Q000032:analysis; D006801:Humans; D007694:Killer Cells, Natural / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000473:pathology
chemical_list: D017252:CD3 Complex; D019002:CD56 Antigen