A survey of nonribosomal peptide synthetase (NRPS) genes in Aspergillus nidulans.
The genome of Aspergillus nidulans carries 27 genes encoding nonribosomal peptide synthetase (NRPS) structures, although only five of these forming peptides and amino acid containing metabolites have been identified so far. This manuscript describes domain structures, substrate binding pockets and related genes and gene clusters and summarizes our current state of product prediction of fungal NRPS systems.
von Döhren
Hans
H
Technical University Berlin, Institute of Chemistry OE2, Franklinstr. 29, 10587 Berlin, Germany. doehren@chem.tu-berlin.de
D001233:Aspergillus nidulans / Q000235:genetics*; D001665:Binding Sites; D005656:Fungal Proteins / Q000235:genetics*; D053858:Metabolic Networks and Pathways / Q000235:genetics; D005810:Multigene Family; D010453:Peptide Synthases / Q000235:genetics*; D017434:Protein Structure, Tertiary
D005656:Fungal Proteins; D010453:Peptide Synthases; C104385:non-ribosomal peptide synthase