title: Sodium tungstate on some biochemical parameters of the parotid salivary gland of streptozotocin-induced diabetic rats: a short-term study.
abstract: Several studies have shown the antidiabetic properties of sodium tungstate. In this study, we evaluated some biochemical parameters of the parotid salivary gland of streptozotocin-induced diabetic rats treated with sodium tungstate solution (2 mg/ml). The studied groups were: untreated control (UC), treated control (TC), untreated diabetic (UD), and treated diabetic (TD). After 2 and 6 weeks of treatment, parotid gland was removed and total protein and sialic acid (free and total) concentration and amylase and peroxidase activities were determined. Data were compared by variance analysis and Tukey test (p < 0.05). The sodium tungstate treatment modestly decreased the glycemia of streptozotocin-induced diabetic rats. At week 2 of the study, parotid gland of diabetic rats presented a reduction of total protein concentration (55%) and an increase of amylase (120%) and peroxidase (160%) activities, free (150%) and total (170%) sialic acid concentration. No alteration in the evaluated parameters at week 6 of the study was observed. Sodium tungstate presented no significant effect in parotid gland. Our results suggest that diabetes causes initial modification in biochemical composition of parotid. However, this gland showed a recovery capacity after 6 week of the experimental time. Sodium tungstate has no effect in peripheral tissues, such as salivary glands.
authors.affiliation: Centro de Pesquisa em Biologia Oral, Faculdade de Odontologia da Universidade de São Paulo, Av Lineu Prestes, 2227, São Paulo, SP, Brazil, CEP 05508-000. maricota@usp.br
authors.forename: Mariana Ferreira
authors.initials: MF
authors.lastname: Leite
authors.forename: José
authors.initials: J
authors.lastname: Nicolau
mesh_terms: D000681:Amylases / Q000378:metabolism; D000704:Analysis of Variance; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005260:Female; D019158:N-Acetylneuraminic Acid / Q000032:analysis; D010306:Parotid Gland / Q000737:chemistry* / Q000187:drug effects* / Q000201:enzymology; D009195:Peroxidase / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D017973:Tungsten Compounds / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D017973:Tungsten Compounds; C025399:sodium tungstate(VI); D009195:Peroxidase; D000681:Amylases; D019158:N-Acetylneuraminic Acid