The ups and downs of SIRT1.
Reversible acetylation has emerged as a key post-translational modification of proteins. Although the number of acetylated proteins is rapidly growing, the ways in which protein acetyltransferases and deacetylases connect with extracellular stimuli remain unclear. Recently, a regulatory network has emerged that controls the expression and activity of SIRT1, a mammalian class-III protein deacetylase. SIRT1 is an important regulator of metabolism, senescence, cancer and, possibly, longevity and is connected with crucial stress-responsive signal-transduction pathways. These connections provide important clues about how protein acetylation and deacetylation mediate cellular adaptations to extrinsic stress.
Kwon
Hye-Sook
HS
Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94158, USA.
Ott
Melanie
M
D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology; D000818:Animals; D031204:Caloric Restriction; D015536:Down-Regulation; D005786:Gene Expression Regulation; D015696:Gene Products, tat / Q000502:physiology; D006801:Humans; D051379:Mice; D009687:Nuclear Proteins / Q000502:physiology; D016716:PC12 Cells; D051381:Rats; D025842:SUMO-1 Protein / Q000502:physiology; D015398:Signal Transduction; D056564:Sirtuin 1; D037761:Sirtuins / Q000096:biosynthesis / Q000502:physiology*; D013312:Stress, Physiological / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic / Q000187:drug effects; D015854:Up-Regulation
D048868:Adaptor Proteins, Signal Transducing; C527450:CCAR2 protein, human; D015696:Gene Products, tat; D009687:Nuclear Proteins; C524448:RPS19BP1 protein, human; D025842:SUMO-1 Protein; D014157:Transcription Factors; C447939:SIRT1 protein, human; D056564:Sirtuin 1; D037761:Sirtuins