Moving targets: rapid evolution of oomycete effectors.
Plant pathogenic microbes secrete proteins known as effectors, which enter the cytoplasm of plant cells and suppress host defences. Known effectors in oomycete pathogens possess an RXLR-EER motif in their amino acid sequence that is necessary for transport of the effector into a host plant cell. A large number of putative effectors have now been identified in oomycete genomes, the sequences of which show evidence of diversifying selection at their C terminus. Here, we describe recent progress in characterizing RXLR-EER effectors and discuss why so many of these rapidly evolving proteins are encoded by the genomes of plant pathogenic oomycetes.
Soanes
Darren M
DM
School of Biosciences, Geoffrey Pope Building, University of Exeter, Stocker Road, Exeter, EX4 4QD, UK.
Talbot
Nicholas J
NJ
D020418:Algal Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D020816:Amino Acid Motifs; D019143:Evolution, Molecular; D009868:Oomycetes / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D010935:Plant Diseases / Q000469:parasitology*; D021381:Protein Transport
D020418:Algal Proteins