title: Trans-stereoselectivity in the reaction between homophthalic anhydride and imines.
abstract: The reaction between homophthalic anhydride and imines in the presence of TiCl4 and diisopropyl ethyl amine is trans-selective. Under these conditions, the reaction using homochiral imines can be highly diastereoselective, thus allowing the synthesis of enantiopure 1,2,3,4-tetrahydro-1-oxoquinoline-4-carboxylic acids.
authors.affiliation: IkerChem Ltd., Tolosa Etorbidea 72, 20018 San Sebastián-Donostia, Spain.
authors.forename: Yosu
authors.initials: Y
authors.lastname: Vara
authors.forename: Tamara
authors.initials: T
authors.lastname: Bello
authors.forename: Eneko
authors.initials: E
authors.lastname: Aldaba
authors.forename: Ana
authors.initials: A
authors.lastname: Arrieta
authors.forename: José L
authors.initials: JL
authors.lastname: Pizarro
authors.forename: María I
authors.initials: MI
authors.lastname: Arriortua
authors.forename: Xabier
authors.initials: X
authors.lastname: Lopez
authors.forename: Fernando P
authors.initials: FP
authors.lastname: Cossío
mesh_terms: D018360:Crystallography, X-Ray; D007097:Imines / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D010796:Phthalic Anhydrides / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D007097:Imines; D010796:Phthalic Anhydrides