title: Use of gastroprotection in patients discharged from hospital on nonsteroidal anti-inflammatory drugs.
abstract: BACKGROUND
  Gastrointestinal (GI) hemorrhage is responsible for 200-400,000 hospitalizations in the United States annually. Nonsteroidal anti-inflammatory drugs (NSAIDs) are responsible for > or =30% of admissions due to GI hemorrhage. Misoprostol reduces the number of NSAID-related upper GI events while proton pump inhibitors (PPIs) reduce the incidence of endoscopic ulcers.
  
  
  OBJECTIVE
  To measure the utilization of GI prophylaxis in patients discharged from hospital on ulcerogenic medicines.
  
  
  METHODS
  We performed a medical record review of all 480 patients discharged from the medical service over a 3-month period on aspirin or nonaspirin NSAIDs. Use of gastroprotection was recorded, particularly among those patients not previously prescribed a PPI or misoprostol. Patients with a different indication for PPI therapy were excluded.
  
  
  RESULTS
  In all, 480 patients were identified, and 142 were excluded. Of the 338 remaining patients, 154 (46%) were prescribed GI prophylaxis. In particular, 240 patients had not been receiving a PPI or misoprostol at the time of admission (gastroprotection naive). Of these, 23.3% received a new prescription for GI prophylaxis at discharge. Use of gastroprotection increased among patients older than 60 years compared with those 60 years and younger (P = 0.008), but there was no difference among patients with higher baseline comorbidity or those receiving multiple agents of interest.
  
  
  CONCLUSIONS
  Although hospitalization offers an opportunity to recognize patients at high risk of developing upper GI complications from NSAIDs, utilization of appropriate gastroprotection seemed suboptimal. Educational efforts directed at physicians may help them recognize risk factors for GI hemorrhage and current indications for prophylaxis.
authors.affiliation: Division of Gastroenterology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA. g-cote@md.northwestern.edu
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Coté
authors.forename: John P
authors.initials: JP
authors.lastname: Norvell
authors.forename: John P
authors.initials: JP
authors.lastname: Rice
authors.forename: William J
authors.initials: WJ
authors.lastname: Bulsiewicz
authors.forename: Colin W
authors.initials: CW
authors.lastname: Howden
mesh_terms: D000367:Age Factors; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D004363:Drug Utilization; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016595:Misoprostol / Q000627:therapeutic use; D010351:Patient Discharge; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D054328:Proton Pump Inhibitors; D016595:Misoprostol