[Advance in the study of compounds inducing the expression of heme oxygenase-1].
Heme oxygenase-1 (HO-1) is a cellular stress protein, and its expression plays an important regulatory role in a lot of physiological and pathological processes. Although the expression of HO-1 in most tissues of body is low, a number of clinical and pharmacological experiments have proved that many compounds can induce HO-1 expression. The increase of HO-1 expression is the result of regulating different signaling pathways and transcription factors, and this induction of HO-1 is suggested to be partially therapeutic efficacy of these compounds. This article summarizes some kinds of compounds in this field of research at home and abroad over the last 10 years, and provides a brief analysis of the mechanism.
Luo
Xue-Lei
XL
School of Medicine, Yangzhou University, Yangzhou 225009, China.
Zhou
Xiao-Xia
XX
Liu
Zhi
Z
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D003374:Coumarins / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D015971:Gene Expression Regulation, Enzymologic; D051547:Heme Oxygenase-1 / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008148:Lovastatin / Q000494:pharmacology; D009569:Nitric Oxide / Q000494:pharmacology*; D036361:Peptide Hormones / Q000494:pharmacology*; D011341:Probucol / Q000494:pharmacology; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism
D000970:Antineoplastic Agents; D000975:Antioxidants; D003374:Coumarins; D004365:Drugs, Chinese Herbal; D036361:Peptide Hormones; D014157:Transcription Factors; D009569:Nitric Oxide; D008148:Lovastatin; C030123:coumarin; D051547:Heme Oxygenase-1; D011341:Probucol