Cerebral neurons involved in the innervation of both the adrenal gland and the ovary: a double viral tracing study.
Previous studies using the viral transneuronal tracing technique demonstrated central autonomic circuits involved in the innervation of the adrenal gland and the ovary. Since the pattern of infection of central nervous system structures is similar after virus inoculation of the adrenal gland and the ovary, and, on the other hand, it is well documented that the activity of the hypothalamo-pituitary-adrenal axis exerts an inhibitory effect on the reproductive system, we investigated whether there are neurons that are transneuronally connected both with the adrenal gland and the ovary. The central circuitry involved in the innervation of the left adrenal and the left ovary was studied in individual rats by dual transneuronal tracing using isogenic recombinant strains (BDG and DS-RED) of Bartha strain of pseudorabies virus. Dual-infected neurons were detected in the ventrolateral medulla, nucleus of the solitary tract, caudal raphe nuclei, A5 cell group, and hypothalamic paraventricular nucleus. The results indicate that there are neurons in the central nervous system that contribute to the transneuronal innervation of both the adrenal gland and the ovary. The data suggest a new type of interaction, i.e. interaction at cellular level that might be involved in regulatory processes integrating the functional activity of the two organs.
Tóth
Ida E
IE
Neuromorphological and Neuroendocrine Research Laboratory, Hungarian Academy of Sciences and Semmelweis University, Department of Human Morphology and Developmental Biology, Budapest, Hungary.
Banczerowski
Péter
P
Boldogkoi
Zsolt
Z
Tóth
Judit S
JS
Szabó
Arnold
A
Halász
Béla
B
Gerendai
Ida
I
D000311:Adrenal Glands / Q000294:innervation*; D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology*; D005260:Female; D011558:Herpesvirus 1, Suid / Q000235:genetics / Q000378:metabolism; D009434:Neural Pathways / Q000033:anatomy & histology*; D009474:Neurons / Q000166:cytology* / Q000821:virology; D010053:Ovary / Q000294:innervation*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000166:cytology; D013194:Staining and Labeling / Q000379:methods*