Management of a pediatric patient on the Berlin Heart Excor ventricular assist device with argatroban after heparin-induced thrombocytopenia.
We report a 15-year-old male patient who developed type II heparin-induced thrombocytopenia (HIT) after 6 weeks of heparin administration and placement of a Berlin Heart Excor left ventricular assist device (LVAD).
Schmitz
Michael L
ML
College of Medicine, The University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. schmitzmichaell@uams.edu
Massicotte
Patti
P
Faulkner
Sherry C
SC
Bhutta
Adnan T
AT
Johnson
Charles E
CE
Seib
Paul M
PM
Frazier
Elizabeth A
EA
Fiser
William P
WP
Imamura
Michiaki
M
Jaquiss
Robert D B
RD
D000293:Adolescent; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects*; D001120:Arginine / Q000031:analogs & derivatives; D001241:Aspirin / Q000008:administration & dosage; D004176:Dipyridamole / Q000008:administration & dosage; D004347:Drug Interactions; D016027:Heart Transplantation; D006353:Heart-Assist Devices; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects*; D006494:Heparin Antagonists / Q000008:administration & dosage; D006801:Humans; D007262:Infusions, Intravenous; D019934:International Normalized Ratio; D007902:Length of Stay; D008297:Male; D010875:Pipecolic Acids / Q000627:therapeutic use*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage; D011479:Protamines / Q000008:administration & dosage; D013449:Sulfonamides; D013917:Thrombin / Q000037:antagonists & inhibitors / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000139:chemically induced*; D013997:Time Factors; D016896:Treatment Outcome; D014859:Warfarin / Q000627:therapeutic use
D000925:Anticoagulants; D006494:Heparin Antagonists; D010875:Pipecolic Acids; D010975:Platelet Aggregation Inhibitors; D011479:Protamines; D013449:Sulfonamides; D014859:Warfarin; D004176:Dipyridamole; D006493:Heparin; D001120:Arginine; D013917:Thrombin; C031942:argatroban; D001241:Aspirin