title: Effectiveness of a noninvasive digital infrared thermal imaging system in the detection of breast cancer.
abstract: BACKGROUND
  Digital infrared thermal imaging (DITI) has resurfaced in this era of modernized computer technology. Its role in the detection of breast cancer is evaluated.
  
  
  METHODS
  In this prospective clinical trial, 92 patients for whom a breast biopsy was recommended based on prior mammogram or ultrasound underwent DITI. Three scores were generated: an overall risk score in the screening mode, a clinical score based on patient information, and a third assessment by artificial neural network.
  
  
  RESULTS
  Sixty of 94 biopsies were malignant and 34 were benign. DITI identified 58 of 60 malignancies, with 97% sensitivity, 44% specificity, and 82% negative predictive value depending on the mode used. Compared to an overall risk score of 0, a score of 3 or greater was significantly more likely to be associated with malignancy (30% vs 90%, P < .03).
  
  
  CONCLUSIONS
  DITI is a valuable adjunct to mammography and ultrasound, especially in women with dense breast parenchyma.
authors.affiliation: Department of Surgery, New York Presbyterian Hospital-Cornell, New York, NY, USA.
authors.forename: Nimmi
authors.initials: N
authors.lastname: Arora
authors.forename: Diana
authors.initials: D
authors.lastname: Martins
authors.forename: Danielle
authors.initials: D
authors.lastname: Ruggerio
authors.forename: Eleni
authors.initials: E
authors.lastname: Tousimis
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: Swistel
authors.forename: Michael P
authors.initials: MP
authors.lastname: Osborne
authors.forename: Rache M
authors.initials: RM
authors.lastname: Simmons
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007259:Infrared Rays; D008327:Mammography; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D013817:Thermography / Q000379:methods*; D016217:Ultrasonography, Mammary