title: Fasting differentially modulates the immunological system: its mechanism and sex difference.
abstract: The immunological properties and hormonal metabolism in rodents are affected by physical and psychological stress more strongly in males than in females. To elucidate the mechanism and physiological significance of the sex difference in the susceptibility of animal to stresses, changes in the immunological system in plasma and intestine and hormonal status in plasma were compared among 8-week-old male and female ICR mice before and after fasting. During the fasting of animals, the expression of immunoglobulin A in intestinal mucosa, and cortisol, interleukin-10 and interferon-gamma in plasma increased. These changes occurred more apparently in males than in females. Under identical conditions, the plasma levels of testosterone decreased markedly with concomitant occurrence of apoptosis in the testis, while the plasma levels of estradiol decreased calmly, and no appreciable apoptosis occurred in the ovary. These results indicate that testosterone enhances the stress-induced modulation of the immune system by some mechanism that was antagonized by estradiol.
authors.affiliation: Department of Basic Research, Kitasato Institute, Tokyo 108-8642, Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Hiramoto
authors.forename: Tamami
authors.initials: T
authors.lastname: Homma
authors.forename: Mika
authors.initials: M
authors.lastname: Jikumaru
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Miyashita
authors.forename: Eisuke F
authors.initials: EF
authors.lastname: Sato
authors.forename: Masayasu
authors.initials: M
authors.lastname: Inoue