Highly efficient route for enantioselective preparation of chlorohydrins via dynamic kinetic resolution.
Dynamic kinetic resolution (DKR) of various aromatic chlorohydrins with the use of Pseudomonas cepacia lipase (PS-C "Amano" II) and ruthenium catalyst 1 afforded chlorohydrin acetates in high yields and high enantiomeric excesses. These optically pure chlorohydrin acetates are useful synthetic intermediates and can be transformed to a range of important chiral compounds.
Träff
Annika
A
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden.
Bogár
Krisztián
K
Warner
Madeleine
M
Bäckvall
Jan-E
JE
D000438:Alcohols / Q000138:chemical synthesis / Q000737:chemistry; D017606:Chlorine Compounds / Q000138:chemical synthesis / Q000737:chemistry; D002728:Chlorohydrins / Q000138:chemical synthesis* / Q000737:chemistry; D004852:Epoxy Compounds / Q000138:chemical synthesis / Q000737:chemistry; D007700:Kinetics; D015394:Molecular Structure; D013237:Stereoisomerism
D000438:Alcohols; D017606:Chlorine Compounds; D002728:Chlorohydrins; D004852:Epoxy Compounds