title: Immunohistochemical study concerning the origin of neurocytoma--a case report.
abstract: A 26-year-old woman presented with rapid tumor growth in her left frontal lobe during 9 years of observation. Operative findings revealed a massive tumor connected to gelatinous, transparent membranous tissue (MT), which extended from the paraventricular zone and continued into the lateral ventricle. Histological diagnosis was atypical neurocytoma. Immunohistochemical analyses revealed that the tumor was strongly positive for not only neural markers but also a glial marker, while the MT was positive for a neural marker. The Ki-67/MIB-1 labeling index was 9.1% in the tumor body and 0% in the MT. Musashi 1, a marker of neural stem cells, was strongly positive in both the tumor body and the MT. We speculate that the tumor growth was due to a rapid decline of the Musashi 1-positive cells to glial differentiation. These cells may be candidates for the origin of the tumor.
authors.affiliation: Department of Neurosurgery, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan. hirohito@gifu-u.ac.jp
authors.forename: Hirohito
authors.initials: H
authors.lastname: Yano
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Ohe
authors.forename: Jun
authors.initials: J
authors.lastname: Shinoda
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Yoshimura
authors.forename: Toru
authors.initials: T
authors.lastname: Iwama
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D019394:Ki-67 Antigen / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D018306:Neurocytoma / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D016601:RNA-Binding Proteins / Q000378:metabolism*; D014057:Tomography, X-Ray Computed
chemical_list: D019394:Ki-67 Antigen; C491297:MSI1 protein, human; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins