title: [Preclinical toxicological evaluation of Pentamang and Mangascan].
abstract: We have carried out a preclinical toxicological investigation (acute toxicity evaluation) of Mangascan (0.5 M solution of manganese(II) - EDTA complex) and Pentamang (0.5 M solution of manganese(II) - DTPA complex), a new paramagnetic contrast agents for MRI procedures. In 14 days after single intravenous introduction of Mangascan (10.0 ml/kg) or Pentamang (5.0 ml/kg) to rats, no any toxic influence of the studied agents was detected in the general condition, bone marrow, cardiovascular and central nervous systems, and liver and kidney functions of experimental animals. No pathological changes were observed in the functional activity and morphology of the internal organs and systems. The results showed that both Mangascan and Pentamang belong to the class of low toxicity substances.
authors.forename: A A
authors.initials: AA
authors.lastname: Churin
authors.forename: G V
authors.initials: GV
authors.lastname: Karpova
authors.forename: T I
authors.initials: TI
authors.lastname: Fomina
authors.forename: T V
authors.initials: TV
authors.lastname: Vetoshkina
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Dubskaia
authors.forename: O L
authors.initials: OL
authors.lastname: Voronova
authors.forename: V D
authors.initials: VD
authors.lastname: Filimonov
authors.forename: M L
authors.initials: ML
authors.lastname: Belianin
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Usov
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000633:toxicity*; D004492:Edetic Acid / Q000633:toxicity*; D005260:Female; D008279:Magnetic Resonance Imaging; D008297:Male; D051379:Mice; D004369:Pentetic Acid / Q000633:toxicity*; D051381:Rats
chemical_list: D003287:Contrast Media; D004369:Pentetic Acid; D004492:Edetic Acid