title: Prevalence of hypothyroidism and importance of cholesterol estimation in patients suffering from major depressive disorder.
abstract: The coexistence of hypothroidism and depression is already reported and both of these conditions are known to share some common clinical symptoms. Serum cholesterol level is known to be altered in either condition considered separately. But, no report is obtained regarding serum cholesterol level when both the conditions coexist. In this study, 78 patients (61 females and 17 males, age ranged 19 to 67 years) suffering from major depressive disorder were included. Serum T3, T4, TSH and cholesterol levels were estimated in all of them. Sixty-two patients were found to be euthyroid and 16 patients (11 females, 5 males) were found to be hypothyroid. Among female patients, 6 had subclinical hypothyroidism and 5 had overt hypothyroidism. Among male patients 3 had subclinical hypothyroidism and 2 had overt hypothyroidism. The overall prevalence of hypothyroidism in major depressive disorder was estimated as 20.5%. Mean serum cholesterol level in 62 euthyroid patients was found to be 150.9% +/- 16 mg% and that of 16 hypothyroid patients to be 190.7 +/- 12 mg% showing a significant difference (p < 0.01). Thus estimation of cholesterol in major depressive disorder patients may give an idea regarding their thyroid status and vice-versa.
authors.affiliation: Department of Biochemistry, Calcutta National Medical College, Kolkata 700014.
authors.forename: Soma
authors.initials: S
authors.lastname: Gupta
authors.forename: Pradip Kumar
authors.initials: PK
authors.lastname: Saha
authors.forename: Ashish
authors.initials: A
authors.lastname: Mukhopadhyay
mesh_terms: D002784:Cholesterol / Q000097:blood*; D003430:Cross-Sectional Studies; D003865:Major Depressive Disorder / Q000453:epidemiology* / Q000503:physiopathology; D005260:Female; D006304:Health Status; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D007037:Hypothyroidism / Q000453:epidemiology* / Q000503:physiopathology; D007194:India / Q000453:epidemiology; D008297:Male; D015995:Prevalence; D012307:Risk Factors; D013961:Thyroid Gland
chemical_list: D002784:Cholesterol