title: [Role of duodenum in regulation of plasma ghrelin level and body mass index after subtotal gastrectomy].
abstract: OBJECTIVE
  To investigate the role of duodenum in regulation of ghrelin and body mass index (BMI) and the correlation between ghrelin and BMI after subtotal gastrectomy.
  
  
  METHODS
  Forty-two patients with T(0-1)N(0-1)M(0) gastric cancer were divided into two groups after gastrectomy according to digestive reconstruction pattern, Billroth I group (n=23) and Billroth II group (n=19) respectively. Plasma ghrelin levels were determined by radioimmunoassay (RIA) before and at day 1, 7, 30 and 360 after gastrectomy,and BMIs were also measured.
  
  
  RESULTS
  Two groups had identical postoperative trends in ghrelin alterations during the early stage, both dropping to nadir at day 1 (36.7% vs 35.7%), then markedly increasing at day 7 (51.0% vs 51.1%). At day 30, ghrelin level of Billroth I group was slightly higher than that of Billroth II group. At day 360, ghrelin level of Billroth I group recovered to 93.6%, approaching though lower than preoperative level and no significant difference was displayed, while ghrelin level of Billroth II group recovered only to 81.6% of preoperational level and significant difference existed (P=0.033). Compared with preoperative levels, ghrelin of two groups decreased by 6.9% and 18.4% while BMI by 3.3% and 6.4% respectively, liner regression correlations were revealed in both groups between decrease magnitudes(R(1)(2)=0.297,P=0.00;R(2)(2)=0.559,P<0.001).
  
  
  CONCLUSIONS
  Anatomico-physiological duodenum compensatively promotes ghrelin recovery, accordingly enhances BMI after gastrectomy. Regarding patients with insufficient ghrelin secretion, ghrelin is positively correlated with BMI.
authors.affiliation: Department of Gastrointestinal Surgery, The Third Affiliated Hospital, Soochow University, Changzhou, China. surgeonwht@163.com
authors.forename: Hai-tao
authors.initials: HT
authors.lastname: Wang
authors.forename: Qi-cheng
authors.initials: QC
authors.lastname: Lu
authors.forename: Qing
authors.initials: Q
authors.lastname: Wang
authors.forename: Rong-chao
authors.initials: RC
authors.lastname: Wang
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Hai-long
authors.initials: HL
authors.lastname: Chen
authors.forename: Hai-xin
authors.initials: HX
authors.lastname: Qian
mesh_terms: D000328:Adult; D015992:Body Mass Index; D004386:Duodenum / Q000378:metabolism*; D005260:Female; D005743:Gastrectomy / Q000379:methods*; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000097:blood* / Q000503:physiopathology* / Q000601:surgery
chemical_list: D054439:Ghrelin