[Research progress in cardiac biological pacemaker created by cell transplantation].
OBJECTIVE
To review the current status and problems in developing cardiac biological pacemaker (CBP) by cell transplantation.


METHODS
The literature over the past decade concerning CBP constructed through cell transplantation was reviewed and summarized.


RESULTS
Experiments in vivo testified that the cell transplantation was feasible for CBP construction, and the transplantation of sinus atrial node cell and stem cell was still the predominant method for constructing CBP. However, such problems as difficult amplification of transferred cardio muscle cell, low success rate of CBP construction as well as unstable function of CBP make it lag behind the tremendous clinical demands. The gene transfection technology might be one of the approaches to resolve these issues.


CONCLUSIONS
As one feasible method for CBP construction, the cell transplantation has a bright future in the clinical application and is worthy of further study.
Fu
Yong
Y
Department of Thoracic and Cardiovascular Surgery, Affiliated Hospital of Luzhou Medical College, Luzhou Sichuan, 646000, P.R. China. fyon001122@163.com
Yu
Fengxu
F
Liao
Bin
B
D000818:Animals; D002304:Cardiac Pacing, Artificial; D017690:Cell Transplantation; D006801:Humans; D010138:Pacemaker, Artificial