title: The first synthesis of a novel 5:7:5-fused diimidazodiazepine ring system and some of its chemical properties.
abstract: The first synthesis of a novel 5:7:5-fused heterocyclic ring system, a diimidazodiazepine, is reported. The propensity of the ring system to undergo facile, acid-catalyzed nucleophilic addition reactions by neutral carbon and nitrogen nucleophiles has been explored. The ring system has potential future applications in mechanistic studies of formation and repair of DNA interstrand cross-links.
authors.affiliation: Laboratory For Drug Design and Synthesis, Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, Maryland 21250, USA.
authors.forename: Raj
authors.initials: R
authors.lastname: Kumar
authors.forename: Ravi K
authors.initials: RK
authors.lastname: Ujjinamatada
authors.forename: Ramachandra S
authors.initials: RS
authors.lastname: Hosmane
mesh_terms: D001381:Azepines / Q000138:chemical synthesis* / Q000737:chemistry; D007093:Imidazoles / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
chemical_list: D001381:Azepines; D007093:Imidazoles; C029899:imidazole