title: New Guaiane Sesquiterpenes from the Fruits of Torilis japonica.
abstract: Three new guaiane type sesquiterpenes were isolated from the methanolic extract of the fruits of Torilis japonica together with a known compound, torilin (1). Their structures were established as 11-acetoxy-8-isobutyryl-4-guaien-3-one (2), 11-acetoxy-8-methacrylyl-4-guaien-3-one (3), and 11-acetoxy-8-propionyl-4-guaien-3-one (4) by spectroscopic methods. These compounds inhibited lipopolysaccharide (LPS)-induced nitric oxide production in murine macrophages RAW 264.7 cells.
authors.affiliation: Division of Biotechnology, College of Environmental and Bioresources Sciences, Chonbuk National University, Jeonju, Korea.
authors.forename: In-Kyoung
authors.initials: IK
authors.lastname: Lee
authors.forename: Jeong-Hyung
authors.initials: JH
authors.lastname: Lee
authors.forename: Eui Il
authors.initials: EI
authors.lastname: Hwang
authors.forename: Bong-Sik
authors.initials: BS
authors.lastname: Yun
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D019661:Apiaceae / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005638:Fruit / Q000737:chemistry; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology*; D045789:Sesquiterpenes, Guaiane / Q000737:chemistry* / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000893:Anti-Inflammatory Agents; D008070:Lipopolysaccharides; D012717:Sesquiterpenes; D045789:Sesquiterpenes, Guaiane; C421026:guaiane; D009569:Nitric Oxide