Nationwide measles epidemic in Ukraine: the effect of low vaccine effectiveness.
The WHO European Region has a measles elimination target for 2010. Between September 2005 and mid-June 2006, more than 50,000 measles cases were reported in Ukraine; many reportedly had received two doses of measles vaccine and over 60% were among persons 15-29 years old. To investigate vaccine effectiveness (VE), a case-control study was undertaken in Dnepropetrovsk region. VE for two doses of measles vaccine was 93.1%, providing insufficient population immunity for measles elimination. An additional dose of measles vaccine for these age-cohorts is required if Ukraine is to achieve measles elimination. Other republics of the former Soviet Union also need to consider a supplemental dose of measles vaccine for older age groups identified epidemiologically to be at increased risk for measles even though individuals may have already received two doses.
Velicko
Inga
I
European Centre for Disease Prevention and Control, Solna, Sweden. inga.velicko@smi.se
Müller
Luise Ledet
LL
Pebody
Richard
R
Gergonne
Bernadette
B
Aidyralieva
Chinara
C
Kostiuchenko
Nina
N
Spika
John S
JS
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D003627:Data Interpretation, Statistical; D004196:Disease Outbreaks; D006801:Humans; D017589:Immunization Programs; D008457:Measles / Q000453:epidemiology* / Q000276:immunology*; D008458:Measles Vaccine / Q000276:immunology*; D011159:Population Surveillance; D018401:Sample Size; D017211:Treatment Failure; D014455:Ukraine / Q000453:epidemiology; D055815:Young Adult
D008458:Measles Vaccine