title: [Role of pathogenicity factors of Staphylococcus aureus in development of atopic dermatitis].
abstract: Factors of pathogenicity of staphylocci and their key role in pathologic process are discussed. Staphylococcus aureus is the leading etiological agent infecting skin of the patients with atopic dermatitis. Development of atopic eczema in patients infected by Staphylococcus aureus is in much determined by wide spectrum of virulence factors inherent to this type of staphylococci. Among those, the more important are proteinases, destroying antimicrobial peptides of derma, toxins, superantigens, which can cause and support of inflammatory reaction in derma during this disease. It was specially noted that pathogenicity factors should be studied as complex system, which formed as a result of long joint evolution of opportunistic microflora and immune system of the host.
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Tiurin
authors.forename: D A
authors.initials: DA
authors.lastname: Dolbin
mesh_terms: D001422:Bacterial Adhesion; D003876:Dermatitis, Atopic / Q000382:microbiology*; D006801:Humans; D013207:Staphylococcal Skin Infections / Q000150:complications*; D013211:Staphylococcus aureus / Q000472:pathogenicity*; D037521:Virulence Factors / Q000502:physiology*
chemical_list: D037521:Virulence Factors