title: Botulinum toxin versus surgical sphincterotomy in females with chronic anal fissure.
abstract: OBJECTIVE
  To compare the effectiveness and the morbidity of botulinum toxin (BTX) in the treatment of chronic anal fissure (CAF) versus the standard surgical sphincterotomy.
  
  
  METHODS
  One hundred female patients with CAF were treated by either closed lateral sphincterotomy [surgical group (Group I, n=50 patients)] or BTX 40 IU [chemical group (Group II, n=50 patients)]. The study was conducted in the King Abdul-Aziz University Hospital, Jeddah, Kingdom of Saudi Arabia, over 3 years between January 2004 and December 2006.
  
  
  RESULTS
  The healing rate was 100% in surgical group with no recurrence on the period of 3 years follow up and one patient has partial permanent incontinence. While in chemical group the healing rate was 86% (p=0.006). Ten patients had transient incontinence (p=0.014). Seven patients had recurrence within 6 months 14% (p=0.006).
  
  
  CONCLUSIONS
  We conclude that chemical sphincterotomy is safe, effective first line treatment in selected female patients with CAF.
authors.affiliation: Department of Surgery, King Abdulaziz University Hospital, PO Box 80215, Jeddah 21589, Kingdom of Saudi Arabia. zkngaithy@hotmail.com
authors.forename: Zuhoor K
authors.initials: ZK
authors.lastname: Algaithy
mesh_terms: D000328:Adult; D001003:Anal Canal / Q000601:surgery*; D001905:Botulinum Toxins / Q000627:therapeutic use*; D002908:Chronic Disease; D005260:Female; D005401:Fissure in Ano / Q000628:therapy*; D006801:Humans; D016896:Treatment Outcome
chemical_list: D001905:Botulinum Toxins