title: Control of jasmonate biosynthesis and senescence by miR319 targets.
abstract: Considerable progress has been made in identifying the targets of plant microRNAs, many of which regulate the stability or translation of mRNAs that encode transcription factors involved in development. In most cases, it is unknown, however, which immediate transcriptional targets mediate downstream effects of the microRNA-regulated transcription factors. We identified a new process controlled by the miR319-regulated clade of TCP (TEOSINTE BRANCHED/CYCLOIDEA/PCF) transcription factor genes. In contrast to other miRNA targets, several of which modulate hormone responses, TCPs control biosynthesis of the hormone jasmonic acid. Furthermore, we demonstrate a previously unrecognized effect of TCPs on leaf senescence, a process in which jasmonic acid has been proposed to be a critical regulator. We propose that miR319-controlled TCP transcription factors coordinate two sequential processes in leaf development: leaf growth, which they negatively regulate, and leaf senescence, which they positively regulate.
authors.affiliation: Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tübingen, Germany.
authors.forename: Carla
authors.initials: C
authors.lastname: Schommer
authors.forename: Javier F
authors.initials: JF
authors.lastname: Palatnik
authors.forename: Pooja
authors.initials: P
authors.lastname: Aggarwal
authors.forename: Aurore
authors.initials: A
authors.lastname: Chételat
authors.forename: Pilar
authors.initials: P
authors.lastname: Cubas
authors.forename: Edward E
authors.initials: EE
authors.lastname: Farmer
authors.forename: Utpal
authors.initials: U
authors.lastname: Nath
authors.forename: Detlef
authors.initials: D
authors.lastname: Weigel
mesh_terms: D017360:Arabidopsis / Q000033:anatomy & histology / Q000235:genetics* / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism; D001483:Base Sequence; D016922:Cellular Senescence / Q000502:physiology*; D003517:Cyclopentanes / Q000378:metabolism*; D020869:Gene Expression Profiling; D018506:Gene Expression Regulation, Plant; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D054883:Oxylipins / Q000378:metabolism*; D018515:Plant Leaves / Q000033:anatomy & histology / Q000502:physiology; D018749:RNA, Plant / Q000235:genetics / Q000378:metabolism*; D016415:Sequence Alignment; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D029681:Arabidopsis Proteins; D003517:Cyclopentanes; D035683:MicroRNAs; D054883:Oxylipins; D018749:RNA, Plant; D014157:Transcription Factors; C011006:jasmonic acid