Vitamin D in chronic kidney disease: is the jury in?
Vitamin D shows promise for improving diverse health outcomes among patients with chronic kidney disease. Observational studies of vitamin D medications have contributed important evidence for broad beneficial clinical effects of vitamin D beyond actions on bone. However, such studies are limited by the potential for confounding by indication. A large randomized controlled trial is now needed to test the hypothesis that vitamin D therapy improves clinical outcomes in patients with kidney disease.
de Boer
Ian H
IH
University of Washington, Division of Nephrology, Seattle, Washington 98195, USA. deboer@u.washington.edu
Kestenbaum
Bryan
B
D002908:Chronic Disease; D006801:Humans; D007674:Kidney Diseases / Q000188:drug therapy* / Q000453:epidemiology; D017891:Pharmacoepidemiology / Q000379:methods*; D016896:Treatment Outcome; D014807:Vitamin D / Q000627:therapeutic use*
D014807:Vitamin D