title: Active metabolites from Dunalia spinosa resinous exudates.
abstract: Dunalia spinosa, a plant used in folk medicine for toothaches, breathing problems and cleansing wounds, was found active as antimicrobial and antioxidant. A new (E)-aurone rutinoside (dunaurone) has been isolated from the aerial parts of the plant, and its structure was determined by spectroscopic means. Lupeol, beta-sitosterol, scopoletin, quercetin and withaferin A were also found. All the extracts exhibited strong antimicrobial activity while dunaurone showed only weak antimicrobial inhibition against Klebsiella pneumoniae; in addition it presented a significant free radical scavenging activity.
authors.affiliation: Department of Pharmacological and Toxicological Chemistry, School of Chemical and Pharmaceutical Sciences, University of Chile, P. O. Box 233, Santiago 1, Chile. serazo@uchile.cl
authors.forename: Silvia
authors.initials: S
authors.lastname: Erazo
authors.forename: Giovanna
authors.initials: G
authors.lastname: Rocco
authors.forename: Mercedes
authors.initials: M
authors.lastname: Zaldivar
authors.forename: Carla
authors.initials: C
authors.lastname: Delporte
authors.forename: Nadine
authors.initials: N
authors.lastname: Backhouse
authors.forename: Consuelo
authors.initials: C
authors.lastname: Castro
authors.forename: Eliana
authors.initials: E
authors.lastname: Belmonte
authors.forename: Franco
authors.initials: F
authors.lastname: Delle Monache
authors.forename: Rubén
authors.initials: R
authors.lastname: García
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D019657:Solanaceae / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013481:Superoxides / Q000378:metabolism; D014969:Xanthine Oxidase / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts; D013481:Superoxides; D014969:Xanthine Oxidase