title: Personality factors associated with methadone maintenance dose.
abstract: OBJECTIVE
  Methadone is the most frequently prescribed medication for the treatment of opioid dependence in the U.S., and questions relating to appropriate dosing of methadone remain an important issue. Given accumulating evidence suggesting an elevated prevalence of personality pathology in opioid dependent populations, as well as evidence of an association between Cluster B characteristics and substance use severity, we hypothesized that patients with such pathology would have elevated methadone dose prescriptions.
  
  
  METHODS
  Participants were 54 opioid dependent individuals recruited from a methadone maintenance clinic.
  
  
  RESULTS
  RESULTS indicated that participants with symptoms consistent with Cluster B pathology had a significantly higher mean prescribed methadone dose relative to participants without Cluster B pathology.
  
  
  CONCLUSIONS
  The presence of personality traits appears to influence methadone maintenance. Implications of this finding are discussed.
authors.affiliation: Boston University, Boston, Massachusetts 02215, USA. hwmurray@bu.edu
authors.forename: Heather
authors.initials: H
authors.lastname: Murray
authors.forename: R K
authors.initials: RK
authors.lastname: McHugh
authors.forename: Evelyn
authors.initials: E
authors.lastname: Behar
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Pratt
authors.forename: Michael
authors.initials: M
authors.lastname: Otto
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008691:Methadone / Q000008:administration & dosage*; D008875:Middle Aged; D009293:Opioid-Related Disorders / Q000534:rehabilitation*; D010552:Personality Assessment; D010554:Personality Disorders / Q000503:physiopathology*; D012720:Severity of Illness Index; D016320:Substance Abuse Treatment Centers; D014481:United States / Q000453:epidemiology
chemical_list: D000701:Analgesics, Opioid; D008691:Methadone