title: Antioxidant and neuroprotective effects of synthesized sintenin derivatives.
abstract: Three series of sintenin derivatives (compounds 1-14) were designed and prepared and their antioxidative and neuroprotective effects were evaluated. The in vitro models of scavenging 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals, chelating ferrous ions, inhibiting the rat brain homogenates lipid peroxidation, and protecting neurons damaged by hydrogen peroxide were employed for bioassays. It was found that sintenin derivatives 4 and 13 showed remarkable antioxidative and neuroprotective activities.
authors.affiliation: Department of TCM and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
authors.forename: Lei Xiang
authors.initials: LX
authors.lastname: Yang
authors.forename: Li Juan
authors.initials: LJ
authors.lastname: Zhang
authors.forename: Ke Xin
authors.initials: KX
authors.lastname: Huang
authors.forename: Xiao
authors.initials: X
authors.lastname: Kun Li
authors.forename: Li Hong
authors.initials: LH
authors.lastname: Hu
authors.forename: Xiao Yu
authors.initials: XY
authors.lastname: Wang
authors.forename: Joachim
authors.initials: J
authors.lastname: Stockigt
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry; D002478:Cells, Cultured; D002614:Chelating Agents / Q000737:chemistry / Q000494:pharmacology; D006861:Hydrogen Peroxide / Q000737:chemistry / Q000494:pharmacology; D015227:Lipid Peroxidation; D009474:Neurons / Q000187:drug effects; D018696:Neuroprotective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D010851:Picrates / Q000737:chemistry; D011422:Propionates / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D002614:Chelating Agents; D018696:Neuroprotective Agents; D010851:Picrates; D011422:Propionates; C499736:sintenin; D006861:Hydrogen Peroxide; C004931:1,1-diphenyl-2-picrylhydrazyl