The effect of organophosphate pesticides on the blood glucose levels in the mouse.
The aim of the present study was to study the effect of two selected agents of this group on blood glucose levels in an animal model. Forty-two adult male mice were divided into 7 groups of 6 each. Animals were exposed by their entire tail for 10 sec once a day for 7 successive days to either 0, 0.1, 1, or 10% azynphos methyl (AZP) malathion (MLT). On days 1,4 and 8, a small drop of blood was taken from tail of the animals that had been kept fasted overnight. Blood glucose levels were measure using a glucometer. The animals then were fed and after 1 h the blood glucose measurement was performed again. Results of this study indicated that the administration of organophosphate agents significantly prevented from the rise of blood glucose after feeding in comparison to the control animals. This reached the level of statistical significance on day 1 with MLT 1% (p < 0.001). It is concluded that exposure with organophosphate pesticides may suppress excessive blood glucose levels with no effect on the basal blood glucose in the fasting animals.
Sadeghi-Hashjin
Goudarz
G
Faculty of Veterinary Medicine, University of Tehran, P.O. Box 6453, Tehran 14155, Iran.
Moslemi
Mahdieh
M
Javadi
Shahram
S
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004435:Eating; D007306:Insecticides / Q000494:pharmacology*; D008294:Malathion / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009943:Organophosphorus Compounds / Q000494:pharmacology*
D001786:Blood Glucose; D007306:Insecticides; D009943:Organophosphorus Compounds; D008294:Malathion