title: Treatment with sunitinib enabled complete resection of massive lymphadenopathy not previously amenable to excision in a patient with renal cell carcinoma.
abstract: We present a case of previously unresectable lymphadenopathy in a patient with renal cell carcinoma treated with sunitinib. Complete resection of a 15-cm left renal cell carcinoma was initially impossible due to massive retroperitoneal disease and encasement of the great vessels and mesenteric vessels. Residual retroperitoneal disease from a radical nephrectomy was treated with the oral, multitargeted receptor tyrosine kinase inhibitor, sunitinib. Tumour shrinkage following five cycles of treatment allowed uncomplicated complete resection of the lymphadenopathy. Follow-up after 6 mo showed no evidence of disease recurrence.
authors.affiliation: Rennes University Hospital, Rennes, France. jean-jacques.patard@univ-rennes1.fr
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Patard
authors.forename: Rodolphe
authors.initials: R
authors.lastname: Thuret
authors.forename: Avakian
authors.initials: A
authors.lastname: Raffi
authors.forename: Brigitte
authors.initials: B
authors.lastname: Laguerre
authors.forename: Karim
authors.initials: K
authors.lastname: Bensalah
authors.forename: Stéphane
authors.initials: S
authors.lastname: Culine
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002292:Carcinoma, Renal Cell / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000150:complications* / Q000188:drug therapy*; D008197:Lymph Node Excision; D008206:Lymphatic Diseases / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011758:Pyrroles / Q000627:therapeutic use*; D000077210:Sunitinib
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D011758:Pyrroles; D000077210:Sunitinib