title: Randomized prospective study on the efficacy of a new revitalizing filler composed of hyaluronic acid (Wipeline).
abstract: OBJECTIVE
  The aim of the study was to test the efficacy of a new revitalizing filler (Wipeline) formed by a buffer physiological solution of hyaluronic acid (HA).
  
  
  METHODS
  A prospective study was performed on 100 patients (aging between 40 and 70 years), with clear signs of premature facial aging. Patients were randomly assigned to two groups, one treated with a HA concentration of 1.6%, the other with a concentration of 2% in the tested product. The treatment protocol consisted of three sessions with a four weeks intervals between them. Visual Analogue Scale (VAS) and digital photos were used to evaluate results after 1, 3, 6 and 12 months from treatment end.
  
  
  RESULTS
  An improvement of turgidity, elasticity and luminosity of the skin and a reduction of folds and wrinkles of the treated areas were observed in both groups. The higher concentrated solution of HA had a more prolonged effect and a greater filling effect. Products were well tolerated and no adverse reactions observed.
  
  
  CONCLUSIONS
  The efficacy of Wipeline has been clinically supported. This revitalizing filler succeeded in increasing skin elasticity and tone by dermal hydration. The procedure is simple and little invasive. It represents a good treatment option to restore vitality and turgidity of skin presenting the signs of aging.
authors.affiliation: Department of Cutaneous and Venereal Diseases and Plastic Surgery, La Sapienza University of Rome, Rome, Italy. lucadessy@hotmail.com
authors.forename: L A
authors.initials: LA
authors.lastname: Dessy
authors.forename: E
authors.initials: E
authors.lastname: Trignano
authors.forename: N
authors.initials: N
authors.lastname: Scuderi
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012060:Rejuvenation
chemical_list: D006820:Hyaluronic Acid