Animal models of sepsis and its complications.
Most currently used animal sepsis models fail to adequately replicate the clinical problem and, therefore, have only limited utility for investigating pathophysiological mechanisms or testing the efficacy of new therapeutic agents. Recent experimental findings support this view and suggest that models of acute infection in mice with pre-existing renal dysfunction may be useful in the development pathway for new therapeutic agents for sepsis.
Fink
Mitchell P
MP
Logical Therapeutics Inc., Waltham, Massachusetts, USA. finkmp@ccm.upmc.edu
D000818:Animals; D000890:Anti-Infective Agents; D004195:Disease Models, Animal; D007674:Kidney Diseases / Q000150:complications* / Q000188:drug therapy; D018805:Sepsis / Q000150:complications / Q000188:drug therapy
D000890:Anti-Infective Agents