Significant clinical improvement in radiation-induced lumbosacral polyradiculopathy by a treatment combining pentoxifylline, tocopherol, and clodronate (Pentoclo).
Radiation-induced (RI) peripheral neuropathy is a rare and severe delayed complication of radiotherapy that is spontaneously irreversible, with no standard of treatment. We previously developed a successful antioxidant treatment in RI fibrosis and necrosis. Two patients with progressive worsening RI lumbosacral polyradiculopathy experienced over several years a significant clinical improvement in their neurological sensorimotor symptoms with long-term pentoxifylline-tocopherol-clodronate treatment, and good safety.
Delanian
Sylvie
S
Oncologie-Radiothérapie, Hôpital Saint-Louis/ APHP, Paris, France. Sylvie.Delanian@sls.aphp.fr
Lefaix
Jean-Louis
JL
Maisonobe
Thierry
T
Salachas
François
F
Pradat
Pierre-François
PF
D000975:Antioxidants / Q000627:therapeutic use*; D004002:Clodronic Acid / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D008875:Middle Aged; D010431:Pentoxifylline / Q000627:therapeutic use*; D011128:Polyradiculopathy / Q000188:drug therapy* / Q000209:etiology; D011832:Radiation Injuries / Q000150:complications; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D024505:Tocopherols / Q000627:therapeutic use*
D000975:Antioxidants; D011837:Radiation-Protective Agents; D004002:Clodronic Acid; D024505:Tocopherols; D010431:Pentoxifylline