title: Feasibility of laparoscopic portal vein ligation prior to major hepatectomy.
abstract: BACKGROUND
  Patients noted to have an inadequate future liver remnant on pre operative volumetric assessment are considered to be candidates for portal vein embolization (PVE). A subset of patients undergo laparoscopic intervention prior to PVE for staging purposes or to address the primary in Stage IV colon cancer. These patients usually undergo PVE as a subsequent additional procedure by the transhepatic route. The aim of this study was to assess the feasibility of portal vein ligation by the laparoscopic approach in suitable patients.
  
  
  METHODS
  A retrospective review of a prospectively maintained database was performed to identify patients that underwent laparoscopic portal vein ligation (LPVL). The demographic, clinical, radiographic, operative and volumetric details were collected to determine the feasibility of portal vein ligation.
  
  
  RESULTS
  A total of nine patients underwent LPVL as part of a two stage procedure in preparation for subsequent major hepatectomy. With a median age of 67 yrs, the diagnoses included: colorectal metastasis (five patients), cholangiocarcinoma (three patients) and hepatocellular carcinoma (one patient). The ligation involved the right portal vein in all and was performed with silk ligature (seven patients) and clips (two patients). Volumetric data was available in six patients which showed a mean increase from 209.1 cc+/-97.76 to 495.83 cc+/-310.91 (increase by 181.5%) In two patients, inadequate hypertrophy mandated later embolization by percutaneous technique. Five patients underwent subsequent major hepatic resection as planned. The remaining four patients were noted to have progression of disease that precluded the planned procedure. There were no complications associated with LPVL.
  
  
  CONCLUSIONS
  LPVL is feasible and can be safely performed. In a select group of patients, it may be considered as an alternative to subsequent embolization and thereby potentially absolve the need for an additional procedure with its attendant complications.
authors.affiliation: Department of Surgery, Eppley Cancer Centre, Division of Surgical Oncology, University of Nebraska Medical Centre, Omaha, NE 68198, USA. chandrakanth@hotmail.com
authors.forename: C
authors.initials: C
authors.lastname: Are
authors.forename: S
authors.initials: S
authors.lastname: Iacovitti
authors.forename: F
authors.initials: F
authors.lastname: Prete
authors.forename: F M
authors.initials: FM
authors.lastname: Crafa