[Histopathologic and ultrastructural study of extraocular muscles in thyroid associated ophthalmopathy].
OBJECTIVE
To investigate histopathologic and ultrastructural changes of extraocular muscles (EOM) in thyroid associated ophthalmopathy (TAO).


METHODS
Twelve EOM specimens from 11 patients with TAO were observed. Each of the specimen was stained with HE and observed by light microscope,and then was sectioned with ultrathin method and observed by transmission electronic microscope.


RESULTS
Under the light microscope, sarcoplasm coagulation,granular degeneration, vacuolization and necrosis were found in the extraocular muscular cells.Under the electronic microscope, there were disturbance and disappearance of the Z line in part of muscular fibers and various degrees of sarcoplasmic reticulum dilatation, myofilament lysis and destruction with formation of vacuoles.In severe cases,the muscular cells could be completely destroyed and phagocytosed by macrophages,fibrosis occurred and myofibroblasts were found in some cases.


CONCLUSIONS
The extraocular muscles in TAO are destroyed at various degrees,and the muscular cells may be the target cells in TAO.
Peng
Juan
J
Department of Ophthalmology, Xiangya Hospital,Central South University,Changsha 410008 China.
Xu
Xue-liang
XL
D000328:Adult; D000368:Aged; D005260:Female; D049970:Graves Ophthalmopathy / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009801:Oculomotor Muscles / Q000473:pathology / Q000648:ultrastructure*