title: Impact of porcine Orexin A on glucagon plasma concentrations in pigs.
abstract: In 1998, Orexin A was added to the long list of orexigenic neuropeptides of the brain's physiology. Orexin A is involved in the central control of appetite and in energy homeostasis, as well as in the regulation of many other physiological functions. It is produced by a small cluster of the brain's neurons, located mainly in and around the lateral hypothalamic area. This site is known to be involved in regulating feeding in mammals. An intracerebroventricular injection of Orexin A into the rat's brain causes an impressive increase in the consumption of food, while an intravenous injection induces changes on glucagon plasma concentrations in rats. In addition, there are signs of changes on glucagon plasma concentrations when Orexin A acts on individual pancreatic islets of rats. In this study, we investigated the potential effects of the central administration of porcine Orexin A on glucagon plasma concentrations in pigs, and examined whether these changes are associated with the possible effect of the neuropeptide on the enteroinsular axis.
authors.affiliation: Aristotle University of Thessaloniki, AHEPA University Hospital, 3rd Surgical Clinic, Greece. pan@med.auth.gr
authors.forename: P
authors.initials: P
authors.lastname: Papakonstantinou
authors.forename: N
authors.initials: N
authors.lastname: Tziris
authors.forename: I
authors.initials: I
authors.lastname: Kesisoglou
authors.forename: A
authors.initials: A
authors.lastname: Gotzamani-Psarrakou
authors.forename: Chr
authors.initials: C
authors.lastname: Tsonidis
authors.forename: M N
authors.initials: MN
authors.lastname: Patsikas
authors.forename: L G
authors.initials: LG
authors.lastname: Papazoglou
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology; D005934:Glucagon / Q000097:blood*; D007276:Injections, Intraventricular; D047908:Intracellular Signaling Peptides and Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D009479:Neuropeptides / Q000008:administration & dosage / Q000494:pharmacology*; D000068797:Orexins; D013552:Swine
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins; D005934:Glucagon