Site-specific self-cleavage of G-quadruplexes formed by human telemetric repeats.
It is demonstrated in our investigations that certain G-quadruplex structures formed by human telomeric repeats could perform self-cleaving actions. Our further studies verify that these reactions are site-specific and undergo hydrolytic pathways.
Li
Xinming
X
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, SPMS-CBC-04-21, Singapore 637616, Singapore.
Ng
Magdeline Tao Tao
MT
Wang
Yifan
Y
Zhou
Tianyan
T
Chua
Sock Teng
ST
Yuan
Weixing
W
Li
Tianhu
T
D020137:Base Pair Mismatch; D001483:Base Sequence; D004247:DNA / Q000737:chemistry; D054856:G-Quadruplexes; D006801:Humans; D006868:Hydrolysis; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D009692:Nucleic Acid Heteroduplexes / Q000737:chemistry; D009841:Oligonucleotides / Q000737:chemistry; D010710:Phosphates / Q000737:chemistry; D016615:Telomere / Q000648:ultrastructure*; D013997:Time Factors
D009692:Nucleic Acid Heteroduplexes; D009841:Oligonucleotides; D010710:Phosphates; D004247:DNA