title: CASP8 D302H and meningioma risk: an analysis of five case-control series.
abstract: Caspase 8 (CASP8) is a key regulator of apoptosis or programmed cell death, and hence a defence against cancer. The CASP8 polymorphism D302H has recently been shown to influence the risk of breast cancer. We tested the hypothesis that the CASP8 polymorphism D302H may influence risk of meningioma through analysis of five independent series of case patients and controls (n=631 and 637, respectively). Carrier status for 302H was not associated with a statistically significantly increased risk (OR=1.16; 95% CI: 0.87-1.53; P=0.31) making it unlikely that this variant contributes to the inherited risk of meningioma.
authors.affiliation: Section of Cancer Genetics, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.
authors.forename: Lara
authors.initials: L
authors.lastname: Bethke
authors.forename: Kate
authors.initials: K
authors.lastname: Sullivan
authors.forename: Emily
authors.initials: E
authors.lastname: Webb
authors.forename: Anne
authors.initials: A
authors.lastname: Murray
authors.forename: Minouk
authors.initials: M
authors.lastname: Schoemaker
authors.forename: Anssi
authors.initials: A
authors.lastname: Auvinen
authors.forename: Anne
authors.initials: A
authors.lastname: Kiuru
authors.forename: Tiina
authors.initials: T
authors.lastname: Salminen
authors.forename: Christoffer
authors.initials: C
authors.lastname: Johansen
authors.forename: Helle Collatz
authors.initials: HC
authors.lastname: Christensen
authors.forename: Kenneth
authors.initials: K
authors.lastname: Muir
authors.forename: Patricia
authors.initials: P
authors.lastname: McKinney
authors.forename: Sarah
authors.initials: S
authors.lastname: Hepworth
authors.forename: Polyxeni
authors.initials: P
authors.lastname: Dimitropoulou
authors.forename: Artitaya
authors.initials: A
authors.lastname: Lophatananon
authors.forename: Maria
authors.initials: M
authors.lastname: Feychting
authors.forename: Stefan
authors.initials: S
authors.lastname: Lönn
authors.forename: Anders
authors.initials: A
authors.lastname: Ahlbom
authors.forename: Beatrice
authors.initials: B
authors.lastname: Malmer
authors.forename: Roger
authors.initials: R
authors.lastname: Henriksson
authors.forename: Anthony
authors.initials: A
authors.lastname: Swerdlow
authors.forename: Richard
authors.initials: R
authors.lastname: Houlston
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D017209:Apoptosis; D016022:Case-Control Studies; D053181:Caspase 8 / Q000235:genetics* / Q000502:physiology; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000235:genetics; D008579:Meningioma / Q000175:diagnosis / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012306:Risk
chemical_list: D053181:Caspase 8