title: Simplifying the complex 1H NMR spectra of fluorine-substituted benzamides by spin system filtering and spin-state selection: multiple-quantum-single-quantum correlation.
abstract: The proton NMR spectra of fluorine-substituted benzamides are very complex (Figure 1) due to severe overlap of (1)H resonances from the two aromatic rings, in addition to several short and long-range scalar couplings experienced by each proton. With no detectable scalar couplings between the inter-ring spins, the (1)H NMR spectra can be construed as an overlap of spectra from two independent phenyl rings. In the present study we demonstrate that it is possible to separate the individual spectrum for each aromatic ring by spin system filtering employing the multiple-quantum-single-quantum correlation methodology. Furthermore, the two spin states of fluorine are utilized to simplify the spectrum corresponding to each phenyl ring by the spin-state selection. The demonstrated technique reduces spectral complexity by a factor of 4, in addition to permitting the determination of long-range couplings of less than 0.2 Hz and the relative signs of heteronuclear couplings. The technique also aids the judicious choice of the spin-selective double-quantum-single-quantum J-resolved experiment to determine the long-range homonuclear couplings of smaller magnitudes.
authors.affiliation: Solid State and Structural Chemistry Unit and NMR Research Centre, Indian Institute of Science, Bangalore 560 012, India.
authors.forename: Bikash
authors.initials: B
authors.lastname: Baishya
authors.forename: G N Manjunatha
authors.initials: GN
authors.lastname: Reddy
authors.forename: Uday Ramesh
authors.initials: UR
authors.lastname: Prabhu
authors.forename: T N Guru
authors.initials: TN
authors.lastname: Row
authors.forename: N
authors.initials: N
authors.lastname: Suryaprakash
mesh_terms: D001549:Benzamides / Q000737:chemistry*; D005461:Fluorine / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods* / Q000592:standards*; D011522:Protons; D011789:Quantum Theory; D012015:Reference Standards
chemical_list: D001549:Benzamides; D011522:Protons; D005461:Fluorine