Total synthesis of the marine macrolide (+)-neopeltolide.
A concise total synthesis of the antiproliferative macrolide (+)-neopeltolide has been completed, utilising a Jacobsen hetero Diels-Alder reaction to install the trisubstituted tetrahydropyran ring.
Paterson
Ian
I
University Chemical Laboratory, Lensfield Road, Cambridge, UK CB2 1EW. ip100@cam.ac.uk
Miller
Natalie A
NA
D000818:Animals; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D011161:Porifera; D013237:Stereoisomerism
D018942:Macrolides; C519136:neopeltolide