title: [Diagnosis and transfusion algorithm for the management of perioperative coagulopathy].
abstract: The present article reviewed the management of coagulopathy in the perioperative setting, following the Japanese practical guidelines for the blood component therapy, edited by the Ministry of Health, Labour and Welfare of Japan in 2005. The threshold concentrations of platelets, prothrombin time international normalized ratio (PT-INR) and activated partial thromboplastin time (APTT) were optimized for the perioperative critical care under active and/or microvascular bleeding, based on currently available randomized controlled trials. Discontinuation or modification of anticoagulants as well as antiplatelets is essential for the safe perioperative care. Several factors, including normothermia, normovolemia, as well as the maintenance of plasma calcium levels within normal range, are important for the management of coagulopathy. Platelet counts, PT, APTT, and if possible, other point-of-care testing including thromboelastography and its modified techniques should be performed following visual inspection of abnormal bleeding. The transfusion algorithms based on causal diagnosis of coagulopathy optimize the risk/ benefit ratio of perioperative transfusion therapy.
authors.affiliation: Department of Anesthesiology, Faculty of Medicine, Saitama Medical University, Saitama 350-0495.
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Azma
authors.forename: Kyoko
authors.initials: K
authors.lastname: Yamasaki
authors.forename: Masashi
authors.initials: M
authors.lastname: Mimasu
authors.forename: Masakazu
authors.initials: M
authors.lastname: Nakao
authors.forename: Hirosato
authors.initials: H
authors.lastname: Kikuchi
mesh_terms: D000465:Algorithms; D001778:Blood Coagulation Disorders / Q000175:diagnosis* / Q000517:prevention & control / Q000628:therapy*; D016913:Blood Component Transfusion; D006801:Humans; D010314:Partial Thromboplastin Time; D019990:Perioperative Care; D010949:Plasma; D017713:Platelet Transfusion; D019095:Point-of-Care Systems; D011517:Prothrombin Time; D018570:Risk Assessment