title: New adaptive chiral thiophene ligands for copper-catalyzed asymmetric Henry reaction.
abstract: A new type of adaptive chiral thiophene-based ligands 3 has been designed and developed. The synthetic flexibility of the thienyl ring allowed for the preparation of polydendate C2-symmetric ligands in good yields, carrying simultaneously "hard" as well as "soft" coordinating atoms (i.e., N, S). The coordination attitude of 3 was then tested in the enantioselective base-free Cu(OAc)(2)-catalyzed addition of nitromethane to aromatic aldehydes, leading to the corresponding beta-nitro alcohols in excellent yields and enantiomeric excesses up to 86%.
authors.affiliation: Dipartimento di Chimica G. Ciamician, Alma Mater Studiorum, University of Bologna, Bologna, Italy. marco.bandini@unibo.it
authors.forename: Marco
authors.initials: M
authors.lastname: Bandini
authors.forename: Salvatore
authors.initials: S
authors.lastname: Cabiddu
authors.forename: Enzo
authors.initials: E
authors.lastname: Cadoni
authors.forename: Pasquale
authors.initials: P
authors.lastname: Olivelli
authors.forename: Riccardo
authors.initials: R
authors.lastname: Sinisi
authors.forename: Achille
authors.initials: A
authors.lastname: Umani-Ronchi
authors.forename: Michele
authors.initials: M
authors.lastname: Usai