title: Sutureless pancreatojejunal anastomosis using an absorbable sealant: evaluation in a pig model.
abstract: BACKGROUND
  Leakage from pancreatojejunal anastomosis continues to be a major source of morbidity in pancreatic surgery. In the present study, we test the hypothesis that a safe, sutureless pancreatojejunal anastomosis can be constructed using a synthetic surgical sealant.
  
  
  METHODS
  Ten pigs weighing 20 to 25 kg underwent distal pancreatectomy and anastomosis of the pancreatic remnant with a jejunal limb with the use of an absorbable surgical sealant. Integrity of the anastomosis was checked on the 10th postoperative d by means of an autopsy study and histological examination.
  
  
  RESULTS
  One animal died on the 3rd postoperative d of peritonitis. The remaining 9 animals had an uneventful postoperative course. Gross and microscopic pathological examination revealed intact pancreatojejunal anastomosis in all surviving animals.
  
  
  CONCLUSIONS
  Following distal pancreatectomy in pigs, pancreatojejunal anastomoses with the use of sealant are technically feasible. During a 10-d observation period, the sealant appeared to prevent anastomotic dehiscence and allow normal anastomotic healing.
authors.affiliation: 1st Department of Anesthesiology, Aretaieion University Hospital, Athens, Greece.
authors.forename: Eriphili
authors.initials: E
authors.lastname: Argyra
authors.forename: George
authors.initials: G
authors.lastname: Polymeneas
authors.forename: Eleni
authors.initials: E
authors.lastname: Karvouni
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Kontorravdis
authors.forename: Theodosios
authors.initials: T
authors.lastname: Theodosopoulos
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Arkadopoulos
mesh_terms: D000818:Animals; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D023421:Models, Animal; D010180:Pancreatectomy; D010193:Pancreaticojejunostomy / Q000379:methods*; D013552:Swine
chemical_list: D015718:Fibrin Tissue Adhesive