Thermo-responsive systems for controlled drug delivery.
Controlled drug delivery systems represent advanced systems that can be tightly modulated by stimuli in order to treat diseases in which sustained drug release is undesirable. Among the many different stimuli-sensitive delivery systems, temperature-sensitive drug delivery systems offer great potential over their counterparts due to their versatility in design, tunability of phase transition temperatures, passive targeting ability and in situ phase transitions. Thus, thermosensitive drug delivery systems can overcome many of the hurdles of conventional drug delivery systems in order to increase drug efficacies, drug targeting and decrease drug toxicities. In an effort to further control existing temperature-responsive systems, current innovative applications have combined temperature with other stimuli such as pH and light. The result has been the development of highly sophisticated systems, which demonstrate exquisite control over drug release and represent huge advances in biomedical research.
Bikram
Malavosklish
M
University of Houston, College of Pharmacy, Department of Pharmacological and Pharmaceutical Sciences, 1441 Moursund Street, Houston, TX 77030, USA. mbikram@uh.edu
West
Jennifer L
JL
D000178:Acrylamides / Q000737:chemistry; D000180:Acrylic Resins; D000818:Animals; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D064420:Drug-Related Side Effects and Adverse Reactions; D005782:Gels; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008081:Liposomes; D010455:Peptides / Q000008:administration & dosage; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D013696:Temperature
D000178:Acrylamides; D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D005782:Gels; D008081:Liposomes; D010455:Peptides; D004364:Pharmaceutical Preparations; D011108:Polymers; C052970:poly-N-isopropylacrylamide; D011092:Polyethylene Glycols