title: Serotype distribution and penicillin resistance of Streptococcus pneumoniae isolates from middle ear fluids of pediatric patients with acute otitis media in Japan.
abstract: Out of 175 pneumococcal isolates from middle ear fluids, 26.3% were penicillin-resistant S. pneumoniae (PRSP). Serotypes 19F and 23F occurred most frequently among PRSP strains. The 7-valent pneumococcal conjugate vaccine (PCV) showed better coverage of PRSP strains (87.0%). The 7-valent PCV may reduce the prevalence of PRSP in Japan.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama-shi, Wakayama 640-8501, Japan.
authors.forename: Muneki
authors.initials: M
authors.lastname: Hotomi
authors.forename: Dewan S
authors.initials: DS
authors.lastname: Billal
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Kamide
authors.forename: Keiko
authors.initials: K
authors.lastname: Kanesada
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Uno
authors.forename: Fumiyo
authors.initials: F
authors.lastname: Kudo
authors.forename: Masato
authors.initials: M
authors.lastname: Ito
authors.forename: Seiji
authors.initials: S
authors.lastname: Kakehata
authors.forename: Rinya
authors.initials: R
authors.lastname: Sugita
authors.forename: Masashi
authors.initials: M
authors.lastname: Ogami
authors.forename: Noboru
authors.initials: N
authors.lastname: Yamanaka
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D004432:Ear, Middle / Q000382:microbiology*; D005122:Exudates and Transudates / Q000382:microbiology*; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D007223:Infant; D007564:Japan / Q000453:epidemiology; D010033:Otitis Media / Q000382:microbiology*; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology; D011008:Pneumococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D022242:Pneumococcal Vaccines / Q000276:immunology; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D010406:Penicillins; D022242:Pneumococcal Vaccines