[Newly developed drugs for osteoporosis in overseas and their future roles for the therapy].
Bisphosphonates are widely used, though gastrointestinal tolerance is a problem on daily administration. Intermittent regimen, from once weekly to once yearly, is now available in overseas and can overcome GI adverse events. New generation of anti-resorptive agents (anti-RANKL antibody and a new SERM, bazedoxifene) are promising and will be soon available for the treatment of osteoporosis. Anabolic agents such as teriparatide and strontium ranelate have marked effects on BMD and reduction on fracture risk. While none of these options is suitable for everyone, the range of future available therapies does mean that most patients can find an intervention that is effective and acceptable.
Wada
Seiki
S
Josai International Univesity, Faculty of Pharmacetical Sciences, Department of Clinical Science.
Fukawa
Takeshi
T
Kamiya
Sadahiro
S
D045930:Anabolic Agents; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D001862:Bone Resorption / Q000188:drug therapy; D000069448:Denosumab; D004164:Diphosphonates; D015195:Drug Design; D019317:Evidence-Based Medicine; D050723:Fractures, Bone / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007093:Imidazoles; D007211:Indoles; D009942:Organometallic Compounds; D010024:Osteoporosis / Q000188:drug therapy*; D053245:RANK Ligand / Q000276:immunology; D020845:Selective Estrogen Receptor Modulators; D019379:Teriparatide; D013876:Thiophenes; D000077211:Zoledronic Acid
D045930:Anabolic Agents; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D007211:Indoles; D009942:Organometallic Compounds; D053245:RANK Ligand; D020845:Selective Estrogen Receptor Modulators; D013876:Thiophenes; C081587:strontium ranelate; D019379:Teriparatide; D000069448:Denosumab; D000077211:Zoledronic Acid; C447119:bazedoxifene