Scaffold diversity of natural products: inspiration for combinatorial library design.
Natural products contain scaffold structures that can be systematically exploited for the design of combinatorial compound libraries with druglike properties. We review approaches for scaffold identification, and compare properties and pharmacophoric features of drugs and natural products. In particular, an application of the self-organizing map technique is presented for natural product-derived compound and library design.
Grabowski
Kristina
K
Institute of Organic Chemistry and Chemical Biology, ZAFES/CMP, Goethe-University, Siesmayerstrasse 70, Frankfurt a.M., Germany.
Baringhaus
Karl-Heinz
KH
Schneider
Gisbert
G
D001688:Biological Products; D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D015394:Molecular Structure
D001688:Biological Products