Severe hepatic dysfunction after sevoflurane exposure.
Sevoflurane is thought to have a potential for hepatotoxicity. A few cases of hepatotoxicity have been reported since it was introduced in 1990 into clinical practice in Japan. The underlying pathophysiology of hepatotoxicity is nonspecific. We report a case of severe hepatic dysfunction after uneventful sevoflurane anesthesia in a child with posterior fossa resection of medulloblastoma. The case of sevoflurane being incriminated is unclear due to various confounding factors that is worthy of discussion.
Alotaibi
Wadha M
WM
Department of Anesthesia, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia. mansalot@hotmail.com
D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D002528:Cerebellar Neoplasms / Q000601:surgery; D056486:Chemical and Drug Induced Liver Injury; D002648:Child; D005260:Female; D006801:Humans; D008527:Medulloblastoma / Q000601:surgery; D008738:Methyl Ethers / Q000009:adverse effects*; D000077149:Sevoflurane
D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane