title: Evaluation of lipoxygenase inhibitory activity of anacardic acids.
abstract: 6-Alkylsalicylic acids inhibit the linoleic acid peroxidation catalyzed by soybean lipoxygenase-1 (EC 1.13.11.12, type 1) competitively and without pro-oxidant effects. This activity is largely dependent on the nature of their alkyl side chains. Inhibitory activities of anacardic acids, viz. 6-pentadec(en)ylsalicylic acids, isolated from the cashew Anacardium occidentale, were initially used for comparison because their aromatic head portions are the same. Consequently, the data should be interpreted to mean that changes in the hydrophobic side chain tail portions of the molecules evaluated correlate with the specific activity determined.
authors.affiliation: Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720-3114, USA. ikubo@calmail.berkeley.edu
authors.forename: Isao
authors.initials: I
authors.lastname: Kubo
authors.forename: Tae Joung
authors.initials: TJ
authors.lastname: Ha
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tsujimoto
authors.forename: Felismino E
authors.initials: FE
authors.lastname: Tocoli
authors.forename: Ivan R
authors.initials: IR
authors.lastname: Green
mesh_terms: D048729:Anacardic Acids / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D016166:Free Radical Scavengers / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D016859:Lipoxygenase Inhibitors / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D048729:Anacardic Acids; D016166:Free Radical Scavengers; D016859:Lipoxygenase Inhibitors