Cytotoxic and anti-oxidant activities of lanostane-type triterpenes isolated from Poria cocos.
A new lanostane-type triterpene, 29-hydroxypolyporenic acid C (8), was isolated from the dried sclerotia of Poria cocos together with eight other known compounds pachymic acid (1), dehydropachymic acid (2), 3-acetyloxy-16alpha-hydroxytrametenolic acid (3), polyporenic acid C (4), 3-epi-dehydropachymic acid (5), 3-epi-dehydrotumulosic acid (6), tumulosic acid (7), and dehydrotumulosic acid (9). The compounds were identified by spectral analysis and comparison with spectroscopic data reported in the literatures. Although none of the nine (1 to 9) compounds showed promising antioxidant activity, 1 through 6 and 8 showed good cytotoxicity against human lung cancer cell line A549 and human prostate cancer cell line DU145. Interestingly, all these compounds exhibited better cytotoxicity towards A549 than DU145 cells.
Zhou
Liang
L
Department of Pharmacy, National University of Singapore, Singapore, Republic of Singapore.
Zhang
Yaochun
Y
Gapter
Leslie Adell
LA
Ling
Hui
H
Agarwal
Rajesh
R
Ng
Ka-Yun
KY
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology*; D000975:Antioxidants / Q000302:isolation & purification* / Q000494:pharmacology*; D001713:Biphenyl Compounds; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007810:Lanosterol / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D010851:Picrates / Q000737:chemistry; D020072:Polyporales / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification
C532901:29-hydroxypolyporenic acid C; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D001713:Biphenyl Compounds; D010851:Picrates; D017382:Reactive Oxygen Species; D014315:Triterpenes; D007810:Lanosterol; C004931:1,1-diphenyl-2-picrylhydrazyl