title: Anti-inflammatory, analgesic and antipyretic activities of Physalis minima Linn.
abstract: In our present investigation, the crude methanol extract and chloroform fraction of the whole plant of Physalis minima Linn (Solanaceae) was investigated for anti-inflammatory, analgesic and antipyretic activities in NMRI mice and Wistar rats of either sex at 200 and 400 mg/kg, respectively. Various established in-vivo model's were used during the study. Both crude extract and chloroform fraction showed marked anti-inflammatory and analgesic activities as compared to a control at tested doses. The antipyretic potential of the crude extract and chloroform were insignificant in the Brewer's yeast fever model. Therefore, the whole plant of Physalis minima Linn could be considered as a potential candidate for bioactivity-guided isolation of natural anti-inflammatory and analgesic agents.
authors.affiliation: Department of Chemistry, Kohat University of Science and Technology, Kohat, 26000, Pakistan. drmalikhan@yahoo.com
authors.forename: Murad Ali
authors.initials: MA
authors.lastname: Khan
authors.forename: Haroon
authors.initials: H
authors.lastname: Khan
authors.forename: Sarwar
authors.initials: S
authors.lastname: Khan
authors.forename: Tahira
authors.initials: T
authors.lastname: Mahmood
authors.forename: Pir Mohammad
authors.initials: PM
authors.lastname: Khan
authors.forename: Abdul
authors.initials: A
authors.lastname: Jabar
mesh_terms: D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D018712:Analgesics, Non-Narcotic / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D002725:Chloroform / Q000737:chemistry; D004195:Disease Models, Animal; D004487:Edema / Q000188:drug therapy / Q000473:pathology; D005260:Female; D007249:Inflammation / Q000188:drug therapy*; D008297:Male; D000432:Methanol / Q000737:chemistry; D051379:Mice; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement / Q000187:drug effects; D032321:Physalis / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D028321:Plant Preparations / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D000700:Analgesics; D018712:Analgesics, Non-Narcotic; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D028321:Plant Preparations; D002725:Chloroform; D000432:Methanol