Development of new synthetic reactions for nitrogen-containing compounds and their application.
Nitrogen-containing compounds are core parts not only of natural and synthetic medicines but also of biologically active compounds including natural products. This review focuses on the development of new synthetic reactions for nitrogen-containing compounds via three methodologies: the reductive photocycloaddition reaction of enamides, radical addition reaction, and nucleophilic addition reaction. Newly developed reactions were successfully applied to the synthesis of various types of nitrogen-containing compounds including medicines, lead compounds to new drugs, natural alkaloids, and others.
Naito
Takeaki
T
Kobe Pharmaceutical University, Kobe, Japan. taknaito@kobepharma-u.ac.jp
D007097:Imines / Q000737:chemistry; D017672:Nitrogen Compounds / Q000138:chemical synthesis*; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis; D010777:Photochemistry; D026361:Reactive Nitrogen Species / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry
D007097:Imines; D017672:Nitrogen Compounds; D004364:Pharmaceutical Preparations; D026361:Reactive Nitrogen Species; D013438:Sulfhydryl Compounds