Design and synthesis of bis-amide and hydrazide-containing derivatives of malonic acid as potential HIV-1 integrase inhibitors.
HIV-1 integrase (IN) is an attractive and validated target for the development of novel therapeutics against AIDS. In the search for new IN inhibitors, we designed and synthesized three series of bis-amide and hydrazide-containing derivatives of malonic acid. We performed a docking study to investigate the potential interactions of the title compounds with essential amino acids on the IN active site.
Sechi
Mario
M
Dipartimento Farmaco Chimico Tossicologico, Università di Sassari, Via Muroni 23/A, 07100 Sassari, Italy. mario.sechi@uniss.it
Azzena
Ugo
U
Delussu
Maria Paola
MP
Dallocchio
Roberto
R
Dessì
Alessandro
A
Cosseddu
Alessia
A
Pala
Nicolino
N
Neamati
Nouri
N
D000577:Amides; D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001386:Azides; D020134:Catalytic Domain; D003198:Computer Simulation; D015195:Drug Design; D019428:HIV Integrase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D008314:Malonates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011485:Protein Binding; D013329:Structure-Activity Relationship
D000577:Amides; D019380:Anti-HIV Agents; D001386:Azides; D019428:HIV Integrase Inhibitors; D008314:Malonates; C030290:malonic acid