Regulation of Schwann cell function by the extracellular matrix.
Laminins and collagens are extracellular matrix proteins that play essential roles in peripheral nervous system development. Laminin signals regulate Schwann cell proliferation and survival as well as actin cytoskeleton dynamics, which are essential steps for radial sorting and myelination of peripheral axons by Schwann cells. Collagen and their receptors promote Schwann cell adhesion, spreading, and myelination as well as neurite outgrowth. In this article, we will review the recent advances in the studies of laminin and collagen function in Schwann cell development.
Chernousov
Michael A
MA
Weis Center for Research, Geisinger Clinic, Danville, Pennsylvania.
Yu
Wei-Ming
WM
Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, New York.
Chen
Zu-Lin
ZL
Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, New York.
Carey
David J
DJ
Weis Center for Research, Geisinger Clinic, Danville, Pennsylvania.
Strickland
Sidney
S
Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, New York.
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D003094:Collagen / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism*; D006801:Humans; D007797:Laminin / Q000378:metabolism*; D009413:Nerve Fibers, Myelinated / Q000378:metabolism / Q000648:ultrastructure; D017933:Peripheral Nervous System / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D012583:Schwann Cells / Q000166:cytology / Q000378:metabolism*
D007797:Laminin; D003094:Collagen