title: Quantitative spectroscopic imaging for non-invasive early cancer detection.
abstract: We report a fully quantitative spectroscopy imaging instrument for wide area detection of early cancer (dysplasia). This instrument provides quantitative maps of tissue biochemistry and morphology, making it a potentially powerful surveillance tool for objective early cancer detection. We describe the design, construction, calibration, and first clinical application of this new system. We demonstrate its accuracy using physical tissue models. We validate its diagnostic ability on a resected colon adenoma, and demonstrate feasibility of in vivo imaging in the oral cavity.
authors.affiliation: George R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. chungyu@mit.edu
authors.forename: Chung-Chieh
authors.initials: CC
authors.lastname: Yu
authors.forename: Condon
authors.initials: C
authors.lastname: Lau
authors.forename: Geoffrey
authors.initials: G
authors.lastname: O'Donoghue
authors.forename: Jelena
authors.initials: J
authors.lastname: Mirkovic
authors.forename: Sasha
authors.initials: S
authors.lastname: McGee
authors.forename: Luis
authors.initials: L
authors.lastname: Galindo
authors.forename: Alphi
authors.initials: A
authors.lastname: Elackattu
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Stier
authors.forename: Gregory
authors.initials: G
authors.lastname: Grillone
authors.forename: Kamran
authors.initials: K
authors.lastname: Badizadegan
authors.forename: Ramachandra R
authors.initials: RR
authors.lastname: Dasari
authors.forename: Michael S
authors.initials: MS
authors.lastname: Feld
mesh_terms: D000236:Adenoma / Q000175:diagnosis* / Q000473:pathology; D002138:Calibration; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000473:pathology; D003952:Diagnostic Imaging / Q000379:methods; D004867:Equipment Design; D006801:Humans; D008403:Mass Screening / Q000379:methods*; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D055095:Optics and Photonics; D019047:Phantoms, Imaging; D011230:Precancerous Conditions / Q000175:diagnosis; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D013057:Spectrum Analysis / Q000295:instrumentation* / Q000379:methods