Cyclin-dependent kinases and cell-cycle transitions: does one fit all?
Cell-cycle transitions in higher eukaryotes are regulated by different cyclin-dependent kinases (CDKs) and their activating cyclin subunits. Based on pioneering findings that a dominant-negative mutation of CDK1 blocks the cell cycle at G2-M phase, whereas dominant-negative CDK2 inhibits the transition into S phase, a model of cell-cycle control has emerged in which each transition is regulated by a specific subset of CDKs and cyclins. Recent work with gene-targeted mice has led to a revision of this model. We discuss cell-cycle control in light of overlapping and essential functions of the different CDKs and cyclins.
Hochegger
Helfrid
H
Helfrid Hochegger is at the Genome Damage and Stability Centre, University of Sussex, Falmer Brighton, BN1 9RQ, UK.
Takeda
Shunichi
S
Hunt
Tim
T
D000818:Animals; D002453:Cell Cycle; D018844:Cyclin-Dependent Kinases / Q000502:physiology*; D016213:Cyclins / Q000502:physiology; D018390:Gene Targeting; D006801:Humans; D051379:Mice
D016213:Cyclins; D018844:Cyclin-Dependent Kinases