title: Primary genotypic resistance of HIV-1 to CCR5 antagonists in CCR5 antagonist treatment-naive patients.
abstract: Resistance to CCR5 antagonists can be driven by mutations in gp120. Sequences from 323 anti-CCR5 naive patients were analyzed for the presence of previously described in-vivo or in-vitro resistance mutations to CCR5 antagonists located in the V3 loop of gp120. The V3 loop region was rather polymorphic, and 7.3% of patients showed viruses with combinations of mutations in V3 loop previously described to be involved in maraviroc resistance, a licensed CCR5 antagonist.
authors.affiliation: UMPC Université Paris 06, Paris, France. cathia.soulie@psl.aphp.fr
authors.forename: Cathia
authors.initials: C
authors.lastname: Soulié
authors.forename: Isabelle
authors.initials: I
authors.lastname: Malet
authors.forename: Sidonie
authors.initials: S
authors.lastname: Lambert-Niclot
authors.forename: Roland
authors.initials: R
authors.lastname: Tubiana
authors.forename: Monique
authors.initials: M
authors.lastname: Thévenin
authors.forename: Anne
authors.initials: A
authors.lastname: Simon
authors.forename: Robert
authors.initials: R
authors.lastname: Murphy
authors.forename: Christine
authors.initials: C
authors.lastname: Katlama
authors.forename: Vincent
authors.initials: V
authors.lastname: Calvez
authors.forename: Anne-Geneviève
authors.initials: AG
authors.lastname: Marcelin
mesh_terms: D065100:CCR5 Receptor Antagonists; D003510:Cyclohexanes / Q000494:pharmacology; D024882:Drug Resistance, Viral / Q000235:genetics*; D005838:Genotype; D015699:HIV Envelope Protein gp120 / Q000235:genetics; D023581:HIV Fusion Inhibitors / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D000077592:Maraviroc; D009154:Mutation; D014230:Triazoles / Q000494:pharmacology
chemical_list: D065100:CCR5 Receptor Antagonists; D003510:Cyclohexanes; D015699:HIV Envelope Protein gp120; D023581:HIV Fusion Inhibitors; D014230:Triazoles; C514793:gp120 protein, Human immunodeficiency virus 1; D000077592:Maraviroc