[Secondary metabolites of a marine actinomycete Streptomyces sp. (No. 195-02) from South China Sea].
The metabolites of a marine streptomyces sp. actinomycete (No. 195-02) were studied and eight compounds were isolated from the fermentation liquid, structures were elucidated by spectroscopy methods as p-hydroxy-benzonitrile (1), 2-methyl-furan-3-carboxylic acid(2), furan-2-carboxylic acid (3), cyclo(Phe-Phe) (4), cyclo(Leu-Ileu) (5), nicotinic acid (6), 2-(1H-indol-3-yl) acetic acid (7) and bis(2-ethylhexyl) phthalate (8). The compounds 1, 3 and 8 were firstly isolated from Streptomyces sp., compounds 4 -7 were firstly found from marine actinomycetes. Coumpouds 4 and 5 evidently inhibited the growth of cancer cell lines hepG2 and hep2 at the concentration of 50 microg/ml.
Li
Chun-Yuan
CY
Department of Applied Chemistry, College of Sciences, South China Agricultural University, Guangzhou 510642, China. chunyuanli@scau.edu.cn
Ding
Wei-Jia
WJ
She
Zhi-Gang
ZG
Lin
Yong-Cheng
YC
D000970:Antineoplastic Agents / Q000494:pharmacology; D002681:China; D002723:Chlorobenzoates / Q000737:chemistry / Q000302:isolation & purification*; D004051:Diethylhexyl Phthalate / Q000737:chemistry / Q000302:isolation & purification; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification*; D007210:Indoleacetic Acids / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D008386:Marine Biology; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000737:chemistry* / Q000378:metabolism
C479620:(6-chloro-2-(4-chlorobenzoyl)-1H-indol-3-yl)acetic acid; D000970:Antineoplastic Agents; D002723:Chlorobenzoates; D005663:Furans; D007210:Indoleacetic Acids; D010456:Peptides, Cyclic; D004051:Diethylhexyl Phthalate; C060089:2-furoic acid