title: Outbreak of bovine tuberculosis featuring anergy to the skin test, udder lesions and milkborne disease in young calves.
abstract: A severe outbreak of bovine tuberculosis in a 1300-head, multisite dairy herd in Great Britain had several unusual features, including anergy to the tuberculin skin test, milkborne disease in calves and a farm cat, and a risk of human infection. The outbreak was controlled by culling 221 cattle over 15 months, by using the gamma-interferon (gamma-IFN) test and by the examination of milk samples. The gamma-IFN test detected infected animals that were not detected by the skin test.
authors.affiliation: Veterinary Laboratories Agency, Kendal Road, Harlescott, Shrewsbury SY1 4HD.
authors.forename: M G
authors.initials: MG
authors.lastname: Houlihan
authors.forename: F W
authors.initials: FW
authors.lastname: Dixon
authors.forename: N A
authors.initials: NA
authors.lastname: Page
mesh_terms: D000818:Animals; D002417:Cattle; D017635:Clonal Anergy; D004196:Disease Outbreaks / Q000662:veterinary*; D005260:Female; D007371:Interferon-gamma / Q000276:immunology; D008198:Lymph Nodes / Q000473:pathology; D008321:Mammary Glands, Animal / Q000473:pathology*; D008892:Milk / Q000382:microbiology*; D012882:Skin Tests / Q000662:veterinary*; D014380:Tuberculosis, Bovine / Q000453:epidemiology* / Q000276:immunology
chemical_list: D007371:Interferon-gamma