title: [An experimental study of polypropylene combined with flap for trachea reconstruction].
abstract: OBJECTIVE
  Canine model established for tracheal defect reconstruction, to investigate the outcome of tracheal reconstruction with combination of polypropylene and flap.
  
  
  METHODS
  About 3.5 to 4 centimeter cervical trachea was resected and replaced with artificial trachea made from monofilament knitted polypropylene and surgical flap. Covered stent was implanted postoperatively. Survival period and quality of life were recorded, bronchofibroscopy, X-ray films and HE sections were performed.
  
  
  RESULTS
  Six dogs survived well and another two died. The causes of death were respiratory failure in 1 and infection in another. Stenosis of anastomosis in 1 was recorded during survival period. The dogs started drinking and eating on the second postoperative day, no dyspnea was found. The animals were sacrificed at 2, 4, 8 weeks and 6 months after surgery. Soft tissue growth was found in polypropylene net 2 weeks after surgery and more at 4 weeks. The polypropylene net was covered completely with soft tissue at 8 weeks and 6 months postoperatively, the hardness and sustentation degree were enhanced following the growth and fibrosis of soft tissue. The squamous epithelium and columnar epithelium were observed healing well by HE staining method.
  
  
  CONCLUSIONS
  One-stage operative artificial trachea made from monofilament knitted polypropylene which has good histocompatibility and surgical flap is the closer artificial trachea to native trachea. It has a promising prospect in clinical use.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Qilu Hospital of Shandong University, Jinan 250012, China.
authors.forename: Xue-Ning
authors.initials: XN
authors.lastname: Zhao
authors.forename: Bo
authors.initials: B
authors.lastname: Cong
authors.forename: Da-Yu
authors.initials: DY
authors.lastname: Liu
authors.forename: Da-Peng
authors.initials: DP
authors.lastname: Lei
authors.forename: Ping
authors.initials: P
authors.lastname: Ye
authors.forename: Kun
authors.initials: K
authors.lastname: Hang
authors.forename: Lei
authors.initials: L
authors.lastname: Yao
authors.forename: Zhong-Hua
authors.initials: ZH
authors.lastname: Zhang
authors.forename: Xin-Liang
authors.initials: XL
authors.lastname: Pan
mesh_terms: D000818:Animals; D004285:Dogs; D011126:Polypropylenes; D019736:Prostheses and Implants; D019651:Plastic Surgery Procedures / Q000295:instrumentation / Q000379:methods*; D016038:Skin Transplantation; D013524:Surgical Flaps; D014132:Trachea / Q000601:surgery*
chemical_list: D011126:Polypropylenes