title: Diversity-oriented synthesis of novel polycyclic scaffolds using polymer-bound reagents.
abstract: A concise sequence utilizing a Petasis three component reaction followed by a tandem aza-Cope-Mannich cyclization afforded novel polycyclic heterocycles in good yield; alternative iminium cyclization based on a Pictet-Spengler reaction or aminal formation led to divergent pathways affording skeletal diversity.
authors.affiliation: Institut de Science et d'Ingénierie Supramoléculaires, Université Louis Pasteur - 67000, Strasbourg, France.
authors.forename: Domingo
authors.initials: D
authors.lastname: García-Cuadrado
authors.forename: Sofia
authors.initials: S
authors.lastname: Barluenga
authors.forename: Nicolas
authors.initials: N
authors.lastname: Winssinger
mesh_terms: D001372:Aza Compounds / Q000737:chemistry; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis; D007202:Indicators and Reagents / Q000737:chemistry*; D008352:Mannich Bases / Q000737:chemistry; D011083:Polycyclic Compounds / Q000138:chemical synthesis*; D011108:Polymers / Q000737:chemistry*
chemical_list: D001372:Aza Compounds; D006571:Heterocyclic Compounds; D007202:Indicators and Reagents; D008352:Mannich Bases; D011083:Polycyclic Compounds; D011108:Polymers