Hemodynamic and serum biochemical alterations associated with intravenous administration of three types of contrast media in anesthetized dogs.
OBJECTIVE
To determine the incidence and type of alterations in heart rate (HR), peak systolic blood pressure (PSBP), and serum biochemical variables (total bilirubin, BUN, and creatinine concentrations) associated with IV administration of ionic-iodinated contrast (IIC), nonionic-iodinated contrast (NIC), and gadolinium dimeglumine (GD) contrast media in anesthetized dogs.


METHODS
280 anesthetized dogs undergoing cross-sectional imaging.


METHODS
HR and PSBP were recorded at 5-minute intervals for 20 minutes for untreated control dogs and dogs that received IIC, NIC, or GD contrast medium. The development of an HR of < 60 beats/min or > 130 beats/min that included a > or = 20% change from baseline was considered a response. The development of PSBP of < 90 mm Hg or > 160 mm Hg that included a > or = 20% change from baseline was considered a response. Pre- and postcontrast serum biochemical values were recorded. Results-Of dogs receiving IIC medium, 3% (3/91) had a response in HR and 4% (4/91) had a response in PSBP at > or = 1 time points. None of the dogs receiving NIC medium had a response in HR; 1 of 16 had a response in PSBP. Of dogs receiving GD contrast medium, 1% (1/92) had a response in HR and 4% (4/92) had a response in PSBP. Of control dogs, 2% (2/81) had a response in HR and 4% (3/81) had a response in PSBP. No serum biochemical alterations were observed.


CONCLUSIONS
IV administration of contrast media in anesthetized dogs caused moderate bradycardia, tachycardia, hypotension, or hypertension.
Pollard
Rachel E
RE
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Puchalski
Sarah M
SM
Pascoe
Peter J
PJ
D000758:Anesthesia / Q000662:veterinary*; D000818:Animals; D001663:Bilirubin / Q000097:blood*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D001806:Blood Urea Nitrogen; D003287:Contrast Media / Q000494:pharmacology*; D003404:Creatinine / Q000097:blood*; D004285:Dogs; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology*; D013599:Systole / Q000187:drug effects / Q000502:physiology
D003287:Contrast Media; D003404:Creatinine; D001663:Bilirubin