title: Signet-ring cell carcinoma arising from the urinary bladder.
abstract: BACKGROUND
  Signet-ring cell carcinoma of the urinary bladder can be primary - arising from the bladder wall or urachus remnants - or metastatic from tumors originating in the stomach, colon, or breast. Saphir first described primary signet-ring cell cancer of the urinary bladder in 1955. Less than 100 cases have been reported in the literature since then.
  
  
  METHODS
  We report a case of a 45-year-old woman who was admitted with gross hematuria. Cystoscopy revealed a necrotic tumor on the left bladder wall. A transurethral biopsy showed signet-ring cell carcinoma. The bladder tumor was diagnosed as the primary one. Radical cystectomy was performed with ureterosigmoidostomy (Mainz pouch II). Histological examination showed a primary signet-ring cell carcinoma of the bladder (pT3bN0M0). Following surgery, the patient received adjuvant chemotherapy with cisplatin and fluorouracil.
  
  
  CONCLUSIONS
  Primary signet-ring cell carcinoma of the urinary bladder is an extremely rare tumor, accounting for approximately 0.24% of all bladder malignances. Patients with this type of cancer generally have a poor prognosis. However, our patient is free of disease 5 years after radical cystectomy.
authors.affiliation: Department of Urology, Semmelweis University, Budapest, Hungary.
authors.forename: Imre
authors.initials: I
authors.lastname: Romics
authors.forename: Eszter
authors.initials: E
authors.lastname: Székely
authors.forename: Attila
authors.initials: A
authors.lastname: Szendroi
mesh_terms: D018279:Carcinoma, Signet Ring Cell / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D015653:Cystectomy; D003558:Cystoscopy; D005260:Female; D006417:Hematuria / Q000209:etiology; D006801:Humans; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery