title: The discovery of statins.
abstract: This year, the Lasker Foundation confers its Clinical Medical Research Award on Akira Endo for his isolation from fungi of statins, potent inhibitors of cholesterol synthesis in the liver. The introduction of statins to clinical practice has markedly reduced morbidity and mortality from atherosclerotic cardiovascular disease.
authors.affiliation: Translational Medicine Unit, Brigham & Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. tstossel@partners.org
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Stossel
mesh_terms: D000818:Animals; D001363:Awards and Prizes; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000517:prevention & control; D002784:Cholesterol / Q000378:metabolism; D049673:History, 20th Century; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000737:chemistry / Q000266:history* / Q000627:therapeutic use; D007564:Japan; D010407:Penicillium / Q000737:chemistry; D014481:United States
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D002784:Cholesterol