The metabolic syndrome, diabetes and lung dysfunction.
Sleep-disordered breathing and sleep apnoea are conditions frequently associated with comorbidity, including obesity, diabetes, hypertension, insulin resistance (metabolic syndrome) and cardiovascular disease. The diabetic state (type 1 and type 2 diabetes) may be associated to diminished lung function and, in particular, decreased vital capacity, and the association between chronic obstructive pulmonary disease (COPD) and type 2 diabetes may be due to a shared inflammatory process. Also, the alteration in circulating endothelial progenitor cells found in respiratory disease, the metabolic syndrome and cardiovascular disease reflect a common condition of endothelial dysfunction.
Tiengo
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Division of Metabolic Diseases, Department of Clinical Medicine, University of Padova, Padova, Italy. antonio.tiengo@unipd.it
Fadini
G P
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Avogaro
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D048909:Diabetes Complications / Q000503:physiopathology; D003920:Diabetes Mellitus / Q000503:physiopathology*; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D008168:Lung / Q000503:physiopathology*; D008171:Lung Diseases / Q000503:physiopathology*; D024821:Metabolic Syndrome / Q000503:physiopathology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology; D012891:Sleep Apnea Syndromes / Q000503:physiopathology; D012893:Sleep Wake Disorders / Q000503:physiopathology