Microgravimetric lectin biosensor based on signal amplification using carbohydrate-stabilized gold nanoparticles.
A highly sensitive microgravimetric lectin biosensor has been developed using carbohydrate-stabilized Au nanoparticles as a signal amplifier; mannose-stabilized Au nanoparticles formed a sandwich-type complex with the target Con A specifically bound to a mannose-modified Au QCM electrode to give an amplified frequency response.
Lyu
Young-Ku
YK
Department of Chemistry and Center for Bioactive Molecular Hybrids, Yonsei University, Seoul 120-749, Korea.
Lim
Kyung-Rae
KR
Lee
Bo Young
BY
Kim
Kwan Soo
KS
Lee
Won-Yong
WY
D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods; D002241:Carbohydrates / Q000737:chemistry*; D003208:Concanavalin A / Q000032:analysis*; D004566:Electrodes; D006046:Gold / Q000737:chemistry*; D008358:Mannose / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D012680:Sensitivity and Specificity; D013499:Surface Properties; D013997:Time Factors
D002241:Carbohydrates; D003208:Concanavalin A; D006046:Gold; D008358:Mannose