title: Leptin concentration indexed to fat mass is increased in untreated anorexia nervosa (AN) patients.
abstract: BACKGROUND
  Data regarding serum adipocytokine and ghrelin concentrations in different stages of anorexia nervosa (AN) is conflicting.
  
  
  OBJECTIVE
  Our aim is to determine serum concentrations of adiponectin (ApN), leptin and ghrelin in different stages of AN and to evaluate their relationships with study parameters.
  
  
  METHODS
  Study group was composed of four subgroups: Group 1: patients with a recent diagnosis of AN (n = 19); group 2: weight recovered (10% increase in body weight compared with baseline) subgroup of group 1 during follow-up (n = 10); group 3: recovered patients with a previous history of AN but normal menstrual cycles and body weight currently (n = 10); group 4: control group (n = 10). Venous blood was obtained for measurements of biochemical/hormonal parameters, ApN, leptin and ghrelin. Body composition was determined by bioimpedance analysis.
  
  
  METHODS
  Changes in adipocytokine and ghrelin concentrations and relationships with anthropometric/biochemical parameters.
  
  
  RESULTS
  Leptin: fat mass (kg) ratio was significantly higher in group 1 patients compared with group 4 (4.3 +/- 4.6 vs. 1.1 +/- 0.5 microg/l kg, P < 0.01). No significant difference was observed among ghrelin concentrations. Leptin showed significant positive correlation with body fat mass in all groups. ApN showed significant positive association with body mass index in Group 1.
  
  
  CONCLUSIONS
  Leptin concentrations indexed to fat mass may indicate a nonphysiological higher set point of leptin per unit fat mass in treatment-naive AN patients. Correlation pattern between ApN and fat mass is modified also. Altered adipocytokine profile in AN may contribute to anorectic behaviour.
authors.affiliation: Department of Internal Medicine, Division of Endocrinology and Metabolism, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. akubatuzum@yahoo.com
authors.forename: Ayse Kubat
authors.initials: AK
authors.lastname: Uzum
authors.forename: Basak
authors.initials: B
authors.lastname: Yucel
authors.forename: Beyhan
authors.initials: B
authors.lastname: Omer
authors.forename: Halim
authors.initials: H
authors.lastname: Issever
authors.forename: Nese Colak
authors.initials: NC
authors.lastname: Ozbey
mesh_terms: D052242:Adiponectin / Q000097:blood; D000273:Adipose Tissue / Q000378:metabolism*; D000328:Adult; D000856:Anorexia Nervosa / Q000097:blood / Q000378:metabolism*; D015992:Body Mass Index; D001835:Body Weight; D005260:Female; D054439:Ghrelin / Q000097:blood; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D055815:Young Adult
chemical_list: D052242:Adiponectin; D054439:Ghrelin; D020738:Leptin