Cutaneous toxoplasmosis histologically mimicking graft-versus-host disease.
The dermatology service is frequently consulted to assess cutaneous eruptions after hematopoietic stem cell transplantation. We describe a case of cutaneous toxoplasmosis in a stem cell transplant patient where toxoplasmosis trophozoites elicited a reaction pattern mimicking an interface dermatitis. At first blush, these findings may be misinterpreted as either a reaction to a drug or graft-versus-host disease. We hope that this case will prove helpful for dermatopathologists in asserting the correct diagnosis of cutaneous toxoplasmosis-if left untreated or treated incorrectly, this disease has a dismal prognosis.
Vidal
Claudia I
CI
Division of Dermatopathology, Mount Sinai School of Medicine, New York, NY 10029, USA.
Pollack
Margaret
M
Uliasz
Annemarie
A
del Toro
Gustavo
G
Emanuel
Patrick O
PO
D000293:Adolescent; D000818:Animals; D003937:Diagnosis, Differential; D006086:Graft vs Host Disease / Q000175:diagnosis* / Q000473:pathology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy; D012867:Skin / Q000469:parasitology / Q000473:pathology; D012876:Skin Diseases, Parasitic / Q000175:diagnosis* / Q000473:pathology; D014122:Toxoplasma / Q000472:pathogenicity; D014123:Toxoplasmosis / Q000175:diagnosis* / Q000473:pathology