[Feasibilities of laboratory diagnosis of cognitive disorders in dyscirculatory encephalopathy].
A hundred and sixty-nine patients aged 51-80 years who had Stages I and II dyscirculatory encephalopathy were examined. A control group comprised 32 apparently healthy individuals of the same age. Cognitive disorders were rated using the mini-mental state examination (MMSE) scale. The serum activities of butyrylcholine esterase (BCE) and gamma-glutamyl transferase (gamma-GT) were studied. The development of moderate cognitive disorders was found to be accompanied by lower BCE and higher gamma-GT activities. The activity levels of these enzymes may be used as markers reflecting the cholinergic and glutamatergic neuromediatory systems involved in cognitive functions.
Bugrova
S G
SG
Bobyreva
E V
EV
Zelinskaia
M V
MV
Kirpicheva
T E
TE
D000368:Aged; D000369:Aged, 80 and over; D002561:Cerebrovascular Disorders / Q000150:complications*; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged