Synergistic effects in gene delivery-a structure-activity approach to the optimisation of hybrid dendritic-lipidic transfection agents.
Novel gene delivery agents based on combining cholesterol units with spermine-functionalised dendrons exhibit enhanced transfection ability-we report significant synergistic effects in mixed (hybrid) systems which combine aspects of both main classes of synthetic vectors, i.e., cationic polymers and lipids.
Jones
Simon P
SP
Department of Chemistry, University of York, Heslington, York, UK YO10 5DD.
Gabrielson
Nathan P
NP
Pack
Daniel W
DW
Smith
David K
DK
D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002784:Cholesterol / Q000737:chemistry*; D004247:DNA / Q000187:drug effects; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems; D015195:Drug Design; D004357:Drug Synergism; D018014:Gene Transfer Techniques; D005822:Genetic Vectors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D013096:Spermine / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014162:Transfection
D050091:Dendrimers; D013096:Spermine; D004247:DNA; D002784:Cholesterol