title: Regulation of Schwann cell function by the extracellular matrix.
abstract: Laminins and collagens are extracellular matrix proteins that play essential roles in peripheral nervous system development. Laminin signals regulate Schwann cell proliferation and survival as well as actin cytoskeleton dynamics, which are essential steps for radial sorting and myelination of peripheral axons by Schwann cells. Collagen and their receptors promote Schwann cell adhesion, spreading, and myelination as well as neurite outgrowth. In this article, we will review the recent advances in the studies of laminin and collagen function in Schwann cell development.
authors.affiliation: Weis Center for Research, Geisinger Clinic, Danville, Pennsylvania.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Chernousov
authors.affiliation: Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, New York.
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Yu
authors.affiliation: Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, New York.
authors.forename: Zu-Lin
authors.initials: ZL
authors.lastname: Chen
authors.affiliation: Weis Center for Research, Geisinger Clinic, Danville, Pennsylvania.
authors.forename: David J
authors.initials: DJ
authors.lastname: Carey
authors.affiliation: Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, New York.
authors.forename: Sidney
authors.initials: S
authors.lastname: Strickland
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D003094:Collagen / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism*; D006801:Humans; D007797:Laminin / Q000378:metabolism*; D009413:Nerve Fibers, Myelinated / Q000378:metabolism / Q000648:ultrastructure; D017933:Peripheral Nervous System / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D012583:Schwann Cells / Q000166:cytology / Q000378:metabolism*
chemical_list: D007797:Laminin; D003094:Collagen