Serum levels of P-selectin in men with high-functioning autism.
Immune dysfunction has been proposed as a mechanism for the pathophysiology of autistic-spectrum disorders. The selectin family of adhesion molecules plays a prominent role in immune/inflammatory responses. We determined the serum levels of three types of soluble-form selectin (sP, sL and sE) in 15 men with high-functioning autism and 22 age-matched healthy controls by enzyme-linked immunosorbent assay. Levels of sP-selectin and sL-selectin were significantly lower in patients than in controls. Furthermore, sP-selectin levels were negatively correlated with impaired social development during early childhood.
Iwata
Y
Y
Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
Tsuchiya
K J
KJ
Mikawa
S
S
Nakamura
K
K
Takai
Y
Y
Suda
S
S
Sekine
Y
Y
Suzuki
K
K
Kawai
M
M
Sugihara
G
G
Matsuzaki
H
H
Hashimoto
K
K
Tsujii
M
M
Sugiyama
T
T
Takei
N
N
Mori
N
N
D001321:Autistic Disorder / Q000097:blood*; D016022:Case-Control Studies; D019040:E-Selectin / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D019041:L-Selectin / Q000097:blood; D008297:Male; D019007:P-Selectin / Q000097:blood*; D055815:Young Adult
D019040:E-Selectin; D019007:P-Selectin; D019041:L-Selectin