title: Exposure assessment of French women and their newborn to brominated flame retardants: determination of tri- to deca- polybromodiphenylethers (PBDE) in maternal adipose tissue, serum, breast milk and cord serum.
abstract: In the frame of a French monitoring program, tri- to deca- polybromodiphenylethers (PBDE) have been measured in maternal and cord serum, adipose tissue, and breast milk samples, collected from 93 volunteer women during caesarean deliveries. The seven major tri- to heptaBDE (BDE-28, 47, 99, 100, 153, 154, and 183) were detected in adipose tissue and breast milk with cumulated median values of 2.59 and 2.51 ng g(-1) l w. Nine highly brominated octa- to decaBDE (BDE-196, 197, 201, 202, 203, 206, 207, 208 and 209) was performed in the same samples, with cumulated median values of 2.73 and 3.39 ng g(-1) l w in adipose tissue and breast milk, respectively. At this opposite, median levels of octa- to decaBDE in maternal and cord serum appeared significantly higher than the levels of tri- to heptaBDE in the same matrices, i.e. 8.85 and 12.34 versus 0.98 and 0.69 ng g(-1) l w, respectively.
authors.affiliation: Laboratoire d'Etude des Résidus et Contaminants dans les Aliments, USC INRA 2013, Ecole Nationale Vétérinaire de Nantes, Route de Gachet, BP 50707, 44307 Nantes Cedex 3, France. antignac@vet-nantes.fr
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Antignac
authors.forename: Ronan
authors.initials: R
authors.lastname: Cariou
authors.forename: Daniel
authors.initials: D
authors.lastname: Zalko
authors.forename: Alain
authors.initials: A
authors.lastname: Berrebi
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Cravedi
authors.forename: Daniel
authors.initials: D
authors.lastname: Maume
authors.forename: Philippe
authors.initials: P
authors.lastname: Marchand
authors.forename: Fabrice
authors.initials: F
authors.lastname: Monteau
authors.forename: Anne
authors.initials: A
authors.lastname: Riu
authors.forename: François
authors.initials: F
authors.lastname: Andre
authors.forename: Bruno
authors.initials: B
authors.lastname: Le Bizec
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005411:Flame Retardants / Q000032:analysis*; D055768:Halogenated Diphenyl Ethers / Q000032:analysis* / Q000097:blood / Q000737:chemistry; D006801:Humans; D007231:Infant, Newborn; D018811:Maternal Exposure; D008895:Milk, Human / Q000737:chemistry*; D008970:Molecular Weight; D012306:Risk; D013048:Specimen Handling
chemical_list: D005411:Flame Retardants; D055768:Halogenated Diphenyl Ethers