Comparison and validation of point of care lactate meters as a replacement for fetal pH measurement.
OBJECTIVE
To validate a point of care lactate device to replace fetal pH measurement.


METHODS
Cord blood samples drawn immediately following delivery were tested on the Nova Lactate Plus and ARKRAY Lactate Pro, the Corometrics 220 pH System, and the Vitros chemistry analyzer (used as lactate reference).


RESULTS
Nova demonstrated a constant positive bias relative to the lactate reference method; while the Lactate Pro correlated well with the reference method up to 6 mmol/L. Receiver operating characteristic (ROC) curve analysis showed optimal sensitivity and specificity for predicting pH<7.20 at lactate values of 6.8 mmol/L for the Nova and 4.8 mmol/L for the Lactate Pro.


CONCLUSIONS
Using Lactate Pro the best cut-off for predicting pH< or =7.20 was 4.8 mM; which coincides with current clinical cut-offs. Thus any lactate device that correlates well with the laboratory reference method can be used with a clinical cut-off of 4.8 mmol/L.
Ridenour
Robert V
RV
Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Gada
Ravi P
RP
Brost
Brian C
BC
Karon
Brad S
BS
D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005323:Fetal Monitoring / Q000295:instrumentation* / Q000379:methods; D005333:Fetus / Q000502:physiology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid / Q000097:blood*; D010920:Placenta / Q000737:chemistry; D011247:Pregnancy; D012372:ROC Curve; D012015:Reference Standards; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D019344:Lactic Acid