title: Retinol binding protein 4 concentrations are influenced by renal function in patients with type 2 diabetes mellitus.
abstract: Retinol binding protein 4 (RBP-4), a newly discovered adipocytokine, has been involved in glucose and lipid metabolism. We assess the impacts of renal function on plasma RBP-4 levels in patients with type 2 diabetes mellitus with a wide range of nephropathy. Plasma RBP-4 levels were measured using the enzyme immunoassay method in 38 type 2 diabetes mellitus patients with nephropathy and were compared with those in 20 patients with normoalbuminuria. The levels of plasma RBP-4 were increased by 1.4- and 3.3-fold in patients with renal disease with macroalbuminuria (P = .04) and end-stage renal disease (plasma creatinine level >2.0 mg/dL) (P < .0001) compared with those in patients with normal renal function. In addition, RBP-4 levels were correlated with the creatinine level and 24-hour creatinine clearance (Ccr) on simple and multiple regression analyses in all patients. Furthermore, in patients having Ccr of more than 60 mL/min, RBP-4 levels were correlated with the homeostasis model assessment (HOMA)-r index and triglyceride (TGL) both on simple and multiple regression analyses. Interestingly, in patients having Ccr of less than 60 mL/min, RBP-4 levels were not correlated with the HOMA-r index and TGL on simple regression analysis. The RBP-4 concentrations are influenced by renal function in type 2 diabetes mellitus patients. In addition, RBP-4 levels were correlated with HOMA-r and TGL in diabetic subjects without end-stage renal disease.
authors.affiliation: Department of Internal Medicine 1, Faculty of Medicine, Oita University, Hasama, Oita 879-5593 Japan. masaki@med.oita-u.ac.jp
authors.forename: Takayuki
authors.initials: T
authors.lastname: Masaki
authors.forename: Futoshi
authors.initials: F
authors.lastname: Anan
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Tsubone
authors.forename: Koro
authors.initials: K
authors.lastname: Gotoh
authors.forename: Seiichi
authors.initials: S
authors.lastname: Chiba
authors.forename: Isao
authors.initials: I
authors.lastname: Katsuragi
authors.forename: Tomoko
authors.initials: T
authors.lastname: Nawata
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kakuma
authors.forename: Hironobu
authors.initials: H
authors.lastname: Yoshimatsu
mesh_terms: D000368:Aged; D000419:Albuminuria / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000097:blood* / Q000503:physiopathology; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D054839:Retinol-Binding Proteins, Plasma / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D003404:Creatinine; D006442:Glycated Hemoglobin; D007328:Insulin; D054839:Retinol-Binding Proteins, Plasma; C101326:RBP4 protein, human