title: Fused tetracycles with a benzene or cyclohexadiene core: [2 + 2 + 2] cycloadditions on macrocyclic systems.
abstract: A series of fused tetracycles with a benzene or cyclohexadiene core (2a-h) is satisfactorily prepared by intramolecular [2 + 2 + 2] cycloadditions of triynic and enediynic macrocycles (1a-h) under RhCl(PPh3)3 catalysis; the enantioselective cycloaddition of macrocycles 1b and 1e and gives chiral tetracycles with moderate enantiomeric excess.
authors.affiliation: Department of Chemistry, Universitat de Girona, Campus de Montilivi, s/n., E-17071-Girona, Spain.
authors.forename: Sandra
authors.initials: S
authors.lastname: Brun
authors.forename: Lídia
authors.initials: L
authors.lastname: Garcia
authors.forename: Iván
authors.initials: I
authors.lastname: González
authors.forename: Anna
authors.initials: A
authors.lastname: Torrent
authors.forename: Anna
authors.initials: A
authors.lastname: Dachs
authors.forename: Anna
authors.initials: A
authors.lastname: Pla-Quintana
authors.forename: Teodor
authors.initials: T
authors.lastname: Parella
authors.forename: Anna
authors.initials: A
authors.lastname: Roglans
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry; D001554:Benzene / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D053138:Cyclohexenes / Q000737:chemistry*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry; D047028:Macrocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D053138:Cyclohexenes; D006576:Heterocyclic Compounds, 4 or More Rings; D047028:Macrocyclic Compounds; D009942:Organometallic Compounds; D012238:Rhodium; D001554:Benzene