[Apoptosis and micro- and macroelement composition of lymphocytes in patients with pulmonary tuberculosis].
The paper describes the results of comparatively analyzing the parameters of apoptosis, micro- and macroelement spectrum of peripheral blood lymphocytes in healthy donors and in patients with chronic obstructive pulmonary disease (COPD) and pulmonary tuberculosis. In drug-responsive and drug-resistant pulmonary tuberculosis, unidirectional pretreatment changes were generally recorded in the activity of apoptosis and the spectrum of chemical elements of peripheral blood lymphocytes, which were most pronounced after completion of a phase of intensive antituberculosis chemotherapy. After termination of a complete course of the therapy, apoptotic activity lowered with the cationic composition of cells being normalized. The parameters differentiating pulmonary tuberculosis from COPD were ascertained, these included increases in the count of apoptotic cells and the cell concentrations of Ca2+, Zn2+, and Mg2+.
Shil'ko
T A
TA
Urazova
O I
OI
Novitskiĭ
V V
VV
Strelis
A K
AK
Voronkova
O V
OV
Filiniuk
O V
OV
Ivanova
E V
EV
Baranova
O V
OV
Tkachenko
S B
SB
D000535:Aluminum / Q000097:blood; D000995:Antitubercular Agents / Q000627:therapeutic use; D017209:Apoptosis; D002118:Calcium / Q000097:blood; D002412:Cations; D003300:Copper / Q000097:blood; D006801:Humans; D007501:Iron / Q000097:blood; D008214:Lymphocytes / Q000737:chemistry* / Q000473:pathology*; D008274:Magnesium / Q000097:blood; D008297:Male; D008345:Manganese / Q000097:blood; D008875:Middle Aged; D018088:Tuberculosis, Multidrug-Resistant / Q000097:blood; D014397:Tuberculosis, Pulmonary / Q000097:blood* / Q000188:drug therapy; D015032:Zinc / Q000097:blood
D000995:Antitubercular Agents; D002412:Cations; D008345:Manganese; D003300:Copper; D000535:Aluminum; D007501:Iron; D008274:Magnesium; D015032:Zinc; D002118:Calcium