Hemodynamic and serum biochemical alterations associated with intravenous administration of three types of contrast media in anesthetized cats.
OBJECTIVE
To determine the incidence and type of alterations in heart rate (HR), peak systolic blood pressure (PSBP), and serum biochemical variables (serum total bilirubin, BUN, and creatinine concentrations) associated with IV administration of ionic-iodinated contrast (IIC), nonionic-iodinated contrast (NIC), and gadolinium (GD) contrast media in anesthetized cats.


METHODS
220 anesthetized cats undergoing cross-sectional imaging.


METHODS
HR and PSBP were recorded at 5-minute intervals for 20 minutes for untreated control cats and cats that received IIC, NIC, or GD contrast medium. The development of HR < 100 beats/min or > 200 beats/min that included a > or = 20% change from baseline was considered a response. The development of PSBP of < 90 mm Hg or > 170 mm Hg that included a > or = 20% change from baseline was considered a response. Pre- and postcontrast serum biochemical values were recorded. Results-Of cats receiving IIC medium, 2% (1/60) had a response in HR at > or = 1 time point. Of cats receiving IIC medium, 7% (4/60) had a response in PSBP. None of the cats receiving NIC medium had a response in HR; 2 of 12 had a response in PSBP. Of cats receiving GD contrast medium, 6% (5/83) had a response in HR and 8% (7/83) had a response in PSBP. None of the control cats had a response in HR or PSBP. No serum biochemical alterations were observed.


CONCLUSIONS
IV administration of iodine and GD contrast media in anesthetized cats was associated with changes in HR and PSBP.
Pollard
Rachel E
RE
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Puchalski
Sarah M
SM
Pascoe
Peter J
PJ
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D002415:Cats / Q000145:classification; D003287:Contrast Media / Q000008:administration & dosage / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology; D006967:Hypersensitivity / Q000503:physiopathology / Q000662:veterinary; D007275:Injections, Intravenous; D008279:Magnetic Resonance Imaging; D013599:Systole / Q000187:drug effects / Q000502:physiology
D003287:Contrast Media