Strontium modified biocements with zero order release kinetics.
Strontium-substituted beta-TCP with the general formula Ca((3-x))Sr(x)(PO(4))(2) (0<x<1) was synthesized by calcination of powder mixtures with the appropriate stoichiometry and reacted with acidic monocalcium phosphate monohydrate (MCPM) to form a cementitious matrix of secondary calcium phosphates. The use of Sr-substituted beta-TCP as a reactant not only induced strontium substitution in the setting products but surprisingly it also favoured the formation of monetite (CaHPO(4)) as setting product, whereas Sr-free cements set to brushite (CaHPO(4).2H(2)O). Release experiments under dynamic conditions for up to 15 days revealed the release of Sr(2+) ions at dose ranges of 12-30 ppm with zero order release kinetic. Cement cytocompatibility was investigated by culturing human osteoblast cell line hFOB1.19 on cement surfaces whereas Sr-containing cements were as good as Sr-free cements in providing a template for cell growth and function.
Hamdan Alkhraisat
Mohammad
M
Departamento de Química Física II, Facultad de Farmacia, UCM, 28040 Madrid, Spain.
Moseke
Claus
C
Blanco
Luis
L
Barralet
Jake E
JE
Lopez-Carbacos
Enrique
E
Gbureck
Uwe
U
D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D001843:Bone Cements / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D002130:Calcium Phosphates / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D002413:Cations, Divalent / Q000737:chemistry / Q000493:pharmacokinetics; D002460:Cell Line; D006801:Humans; D013324:Strontium / Q000737:chemistry / Q000493:pharmacokinetics; D014961:X-Ray Diffraction
D001672:Biocompatible Materials; D001843:Bone Cements; D002130:Calcium Phosphates; D002413:Cations, Divalent; C485817:beta-tricalcium phosphate; D013324:Strontium