title: Responsiveness of short-lasting unilateral neuralgiform headache with conjunctival injection and tearing to hypothalamic deep brain stimulation.
abstract: Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT) is a severe primary headache disorder that is often refractory to medical therapy. Although the pathogenesis of this and other trigeminal autonomic cephalalgias is not completely understood, ipsilateral activation of the posterior and inferior hypothalamus has been identified on functional imaging studies during attacks. The authors report on a case of SUNCT syndrome successfully treated with hypothalamic deep brain stimulation and discuss the current literature.
authors.affiliation: Department of Neurological Surgery, Mayo Clinic Arizona, Pheonix, Arizona 85054, USA. lyons.mark2@mayo.edu
authors.forename: Mark K
authors.initials: MK
authors.lastname: Lyons
authors.forename: David W
authors.initials: DW
authors.lastname: Dodick
authors.forename: Virgilio Gerald H
authors.initials: VG
authors.lastname: Evidente
mesh_terms: D001931:Brain Mapping; D003228:Conjunctiva / Q000294:innervation*; D046690:Deep Brain Stimulation / Q000379:methods*; D004292:Dominance, Cerebral / Q000502:physiology; D004567:Electrodes, Implanted; D006261:Headache / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D007031:Hypothalamus / Q000503:physiopathology*; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013666:Tears / Q000502:physiology*; D016896:Treatment Outcome; D014277:Trigeminal Neuralgia / Q000503:physiopathology / Q000628:therapy*