title: Synthesis and evaluation of novel boron-containing complexes of potential use for the selective treatment of malignant melanoma.
abstract: Boron-containing complexes that have the potential to irreversibly accumulate in melanoma cells have been prepared by reaction of amino acids with 9-methoxy-9-borabicyclo[3.3.1]nonane. The ability of each complex to act as a substrate for tyrosinase has been probed by oximetry. Increased uptake of the lead candidate in a tyrosinase-rich cell line, compared with a tyrosinase-absent cell line, is reported, with results correlating well with that for a drug currently approved for BNCT.
authors.affiliation: Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, 08028 Barcelona, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Bonjoch
authors.forename: Michael G B
authors.initials: MG
authors.lastname: Drew
authors.forename: Asensio
authors.initials: A
authors.lastname: González
authors.forename: Francesca
authors.initials: F
authors.lastname: Greco
authors.forename: Samaila
authors.initials: S
authors.lastname: Jawaid
authors.forename: Helen M I
authors.initials: HM
authors.lastname: Osborn
authors.forename: Nana Aba O
authors.initials: NA
authors.lastname: Williams
authors.forename: Parveen
authors.initials: P
authors.lastname: Yaqoob
mesh_terms: D001896:Boron Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology*; D015394:Molecular Structure; D010084:Oxidation-Reduction / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D001896:Boron Compounds