Metabolic syndrome is associated with erosive esophagitis.
OBJECTIVE
To clarify whether insulin resistance and metabolic syndrome are risk factors for erosive esophagitis.


METHODS
A case-control study was performed using the database of the Kangbuk Samsung Hospital Medical Screening Center.


RESULTS
A total of 1679 cases of erosive esophagitis and 3358 randomly selected controls were included. Metabolic syndrome was diagnosed in 21% of the cases and 12% of the controls (P < 0.001). Multiple logistic regressions confirmed the association between erosive esophagitis and metabolic syndrome (Odds ratio, 1.25; 95% CI, 1.04-1.49). Among the components of metabolic syndrome, increased waist circumference, elevated serum triglyceride levels and hypertension were significant risk factors for erosive esophagitis (all P < 0.01). Furthermore, increased insulin resistance (Odds ratio, 0.91; 95% CI, 0.85-0.98) and fatty liver, as diagnosed by ultrasonography (Odds ratio, 1.39; 95% CI, 1.20-1.60), were also related to erosive esophagitis even after adjustment for a series of confounding factors.


CONCLUSIONS
Metabolic syndrome and increased insulin resistance are associated with an increased risk of developing erosive esophagitis.
Park
Jung-Ho
JH
Department of Medicine, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, South Korea. pjho3@hotmail.com
Park
Dong-Il
DI
Kim
Hong-Joo
HJ
Cho
Yong-Kyun
YK
Sohn
Chong-Il
CI
Jeon
Woo-Kyu
WK
Kim
Byung-Ik
BI
D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004941:Esophagitis / Q000209:etiology* / Q000473:pathology; D005260:Female; D005764:Gastroesophageal Reflux / Q000209:etiology; D006801:Humans; D007333:Insulin Resistance; D007723:Korea; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications*; D008875:Middle Aged; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D014280:Triglycerides