title: Craniocervical paraganglioma with numerous pulmonary metastases--case report.
abstract: A 28-year-old man presented with a rare craniocervical paraganglioma with multiple pulmonary metastases manifesting as hearing disturbance, hoarseness, and dysphagia in February 2003. Magnetic resonance imaging depicted a large jugular foramen tumor extending to the deep cervical region. Chest computed tomography revealed numerous small pulmonary nodules. The jugular tumor was totally resected immediately after preoperative embolization. Histological examination revealed paraganglioma. Localized irradiation (54 Gy) and two courses of combination chemotherapy consisting of paclitaxel (80 mg/m(2)) and gemcitabine (1000 mg/m(2)) were given. The patient remained well during follow up for 48 months and the number of pulmonary metastases did not increase. Local control of primary craniocervical paraganglioma by palliative surgical resection may be effective for control of metastatic lesions.
authors.affiliation: Department of Neurosurgery, the University of Hokkaido, Graduate School of Medicine, Sapporo, Hokkaido, Japan. yk156@yahoo.co.jp
authors.forename: Yuuta
authors.initials: Y
authors.lastname: Kamoshima
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sawamura
authors.forename: Masaaki
authors.initials: M
authors.lastname: Hokari
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Iwasaki
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Akita
mesh_terms: D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002574:Cervical Vertebrae; D003131:Combined Modality Therapy; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D005925:Glomus Jugulare Tumor / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D008297:Male; D017239:Paclitaxel / Q000008:administration & dosage; D010235:Paraganglioma / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D016896:Treatment Outcome; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D000972:Antineoplastic Agents, Phytogenic; D003841:Deoxycytidine; D017239:Paclitaxel; D000093542:Gemcitabine