On the thermodynamics of cocrystal formation.
The thermodynamics underpinning cocrystal formation are derived. The results provide the pharmaceutical scientist with the foundation to experimentally assess the thermodynamic stability of a cocrystal with respect to its component forms. Data for the carbamazepine-nicotinamide system are discussed as an example.
Schartman
Richard R
RR
Bristol-Myers Squibb, 5 Research Parkway, Wallingford, CT 06492, United States. richard.schartman@bms.com
D002220:Carbamazepine / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D004355:Drug Stability; D009536:Niacinamide / Q000737:chemistry*; D013816:Thermodynamics
D009536:Niacinamide; D002220:Carbamazepine