title: Factors associated with treatment failure in childhood tuberculosis.
abstract: We retrospectively reviewed records of 541 children (315 boys) suffering from tuberculosis, median age 95 (range 2-180) months, to determine factors associated with treatment failure. 256 (47.3%) children had pulmonary tuberculosis (PTB) while 285 (52.7%) had extrapulmonary tuberculosis (EPTB). 459 (84.8%) children were cured and 82 (15.5%) had treatment failure. On bivariate analysis, AFB positivity [OR= 2.13 (95% CI 1.18- 3.85)], non-receipt of BCG vaccination during infancy [OR=1.73 (1.02- 2.91)] and EPTB [1.9 (1.16- 3.11)] were associated with treatment failure. On multivariate analysis, only extrapulmonary tuberculosis was significantly associated with treatment failure.
authors.affiliation: Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Sindhu
authors.initials: S
authors.lastname: Sivanandan
authors.forename: Mandeep
authors.initials: M
authors.lastname: Walia
authors.forename: Rakesh
authors.initials: R
authors.lastname: Lodha
authors.forename: S K
authors.initials: SK
authors.lastname: Kabra
mesh_terms: D000293:Adolescent; D001500:BCG Vaccine / Q000276:immunology / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D015999:Multivariate Analysis; D012307:Risk Factors; D017211:Treatment Failure; D014376:Tuberculosis / Q000188:drug therapy*
chemical_list: D001500:BCG Vaccine