Design, synthesis and in vitro microbiological evaluation of 6,6-dimethyl-7,9-diaryl-1,2,4,8-tetraazaspiro[4.5]decan-3-thiones--a new series of 'tailor-made' compounds.
Some novel 'tailor-made' compounds, 6,6-dimethyl-7,9-diaryl-1,2,4,8-tetraazaspiro[4.5]decan-3-thiones 23-27 have been studied for their in vitro antibacterial activity against Staphylococcus aureus, beta-Heamolytic streptococcus, Vibreo cholerae, Salmonella typhii, Shigella felxneri, Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa and anti-fungal activity against Aspergillus flavus, Mucor, Rhizopus and Microsporum gypsuem. Compounds 24 and 25 exerted potent antibacterial activity against S. aureus, beta-H. streptococcus, E. coli and P. aeruginosa whereas all compounds 23-27 exerted strong in vitro antifungal activity against A. flavus, Mucor and Rhizopus.
Gopalakrishnan
M
M
Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University, Annamalainagar, Tamil Nadu, India. profmgk@yahoo.co.in
Thanusu
J
J
Kanagarajan
V
V
Govindaraju
R
R
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability; D013211:Staphylococcus aureus / Q000187:drug effects / Q000378:metabolism; D013871:Thiones / Q000138:chemical synthesis* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D013871:Thiones