title: Surgical outcomes and survival after multiorgan resection for locally advanced gastric cancer.
abstract: BACKGROUND
  Multiple organ resection for locally advanced (assumed T4) gastric cancer is associated with high morbidity and mortality. Our aim was to evaluate the efficacy of these surgeries with regard to surgical morbidity, mortality, and survival.
  
  
  METHODS
  Fifty-six patients underwent potentially radical gastrectomy combined with invaded organ resection. Early and late results of multiorgan resection and clinicopathologic factors influencing these results were evaluated.
  
  
  RESULTS
  Forty patients (71.4%) received 1 additional organ resection and 16 patients (28.6%) received 2 or more additional organ resections. Postoperative morbidity and mortality was 37.5% and 12.5%, respectively. Resection of 2 or more additional organs increased postoperative morbidity and advanced age increased mortality. The 1- and 3-year survival rates were 53.3% and 28.1%, respectively. Advanced age, lymph node metastasis, and resection of more than 1 additional organ were significant prognostic factors for survival.
  
  
  CONCLUSIONS
  For patients with locally advanced gastric carcinoma, multiple organ resection is worthwhile with careful patient selection.
authors.affiliation: Turkiye Yuksek Ihtisas Training and Research Hospital, Mamak, Ankara, Turkey. ilterozer@yahoo.com
authors.forename: Ilter
authors.initials: I
authors.lastname: Ozer
authors.forename: E Birol
authors.initials: EB
authors.lastname: Bostanci
authors.forename: Taner
authors.initials: T
authors.lastname: Orug
authors.forename: Yusuf B
authors.initials: YB
authors.lastname: Ozogul
authors.forename: Murat
authors.initials: M
authors.lastname: Ulas
authors.forename: Metin
authors.initials: M
authors.lastname: Ercan
authors.forename: Can
authors.initials: C
authors.lastname: Kece
authors.forename: Fuat
authors.initials: F
authors.lastname: Atalay
authors.forename: Musa
authors.initials: M
authors.lastname: Akoglu
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016629:Esophagectomy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology*; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D012189:Retrospective Studies; D013156:Splenectomy / Q000379:methods*; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D015996:Survival Rate / Q000639:trends; D013997:Time Factors; D016896:Treatment Outcome