title: Tandem palladium-catalyzed N,C-coupling/carbonylation sequence for the synthesis of 2-carboxyindoles.
abstract: Tandem palladium-catalyzed N,C-coupling/carbonylation, under 10 atm of carbon monoxide and at 110 degrees C, is a novel and efficient method for the preparation of 2-carboxyindoles. The catalyst system tolerates a variety of functional groups, and the noted indoles were obtained in good isolated yields.
authors.affiliation: Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario, Canada K1N 6N5.
authors.forename: Tiago O
authors.initials: TO
authors.lastname: Vieira
authors.forename: Laura A
authors.initials: LA
authors.lastname: Meaney
authors.forename: Yong-Ling
authors.initials: YL
authors.lastname: Shi
authors.forename: Howard
authors.initials: H
authors.lastname: Alper
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*
chemical_list: D002264:Carboxylic Acids; D007211:Indoles; D010165:Palladium; D009584:Nitrogen