title: Do intrinsic factor antibodies assays provide univocal answers in Biermer's disease?
abstract: The objective of the study is to evaluate the concordance of four assays for antibodies against intrinsic factor (IF-Ab). Sixty-two sera were tested with one competitive automated and three manual noncompetitive assays. Thirty-five percent patients had discordant results with at least one of the four assays. However, any method uncovered patients with proven Biermer's disease missed by the others assays. The observed discordance partly explains the poor sensitivity of IF-Ab in studies using a single assay.
authors.affiliation: Department of Nuclear Medicine, University Hospital of Bordeaux, Bordeaux, France. jean-benoit.corcuff@chu-bordeaux.fr
authors.forename: Jean-Benoît
authors.initials: JB
authors.lastname: Corcuff
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Morel
authors.forename: Agnès
authors.initials: A
authors.lastname: Georges
authors.forename: Karine
authors.initials: K
authors.lastname: de Bosredon
authors.forename: Laurence
authors.initials: L
authors.lastname: Bordenave
mesh_terms: D000752:Anemia, Pernicious / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D001323:Autoantibodies / Q000097:blood*; D003937:Diagnosis, Differential; D006801:Humans; D007437:Intrinsic Factor / Q000276:immunology*; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D014806:Vitamin B 12 Deficiency / Q000097:blood / Q000175:diagnosis* / Q000209:etiology
chemical_list: D001323:Autoantibodies; D007437:Intrinsic Factor