title: Immunomodulatory effect of resistin in human dendritic cells stimulated with lipoteichoic acid from Staphylococcus aureus.
abstract: Resistin is an adipokine whose physiologic role in obesity, type II diabetes mellitus, and inflammatory diseases has been a subject of debate because while it is expressed in adipocytes and adipose tissue in mouse, it is expressed in leukocytes, such as macrophages, in human. In the present study, we attempt to define the effect of resistin on human dendritic cells (DCs) derived from CD14(+) monocytes. When DCs were stimulated with lipoteichoic acid (LTA) and treated with various concentrations of resistin, antigen-uptake process and the endocytic capacity of DCs were decreased. It is intriguing that resistin attenuated cytokine production in LTA-primed DCs. Consequently, T cell activity was reduced when lymphocytes were mixed with Staphylococcus aureus-primed autologous DCs treated with resistin compared to S. aureus-primed DCs without resistin. Our results suggest that resistin interferes with the efficacy of immune responses activated by Gram-positive bacterial infection in human DCs.
authors.affiliation: Department of Agricultural Biotechnology, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul 151-921, Republic of Korea.
authors.forename: Young Min
authors.initials: YM
authors.lastname: Son
authors.forename: Sung Min
authors.initials: SM
authors.lastname: Ahn
authors.forename: Mi Seon
authors.initials: MS
authors.lastname: Jang
authors.forename: Yang Soo
authors.initials: YS
authors.lastname: Moon
authors.forename: Sang Hoon
authors.initials: SH
authors.lastname: Kim
authors.forename: Kwang-Keun
authors.initials: KK
authors.lastname: Cho
authors.forename: Seung Hyun
authors.initials: SH
authors.lastname: Han
authors.forename: Cheol-Heui
authors.initials: CH
authors.lastname: Yun
mesh_terms: D017951:Antigen Presentation / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects / Q000276:immunology; D002478:Cells, Cultured; D016207:Cytokines / Q000276:immunology; D003713:Dendritic Cells / Q000187:drug effects* / Q000276:immunology; D004705:Endocytosis / Q000187:drug effects / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000276:immunology / Q000494:pharmacology; D052243:Resistin / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000276:immunology; D013682:Teichoic Acids / Q000276:immunology / Q000494:pharmacology; D018417:Th1 Cells / Q000187:drug effects / Q000276:immunology; D018418:Th2 Cells / Q000187:drug effects / Q000276:immunology
chemical_list: D016207:Cytokines; D007166:Immunosuppressive Agents; D008070:Lipopolysaccharides; D052243:Resistin; D013682:Teichoic Acids; C009900:lipoteichoic acid