Lowering of intraocular pressure by topical application of Daucus carota seed extract in rabbits.
In normotensive rabbits topical application of Daucus carota seed extract at the concentration of 0.3, 0.6 and 1.2% resulted in mean IOP reduction of 19.33. 23.20 and 25.61% respectively from baseline. As no significant difference was observed between the change in IOP in 0.6 and 1.2% extract treated groups, 0.6% concentration was chosen for further evaluation in rabbits with experimentally elevated IOP. In water loaded rabbits, maximum mean IOP reduction with 0.6% extract was 29.39%, which was comparable to pilocarpine. In steroid pretreated rabbits, maximum mean IOP reduction was 30.27% from baseline, which was significantly higher than pilocarpine. The extract showed a comparatively slower onset of action however, the duration of action was comparable to pilocarpine in all the experimental models.
Agarwal
Renu
R
Department of Pharmacology, Delhi Institute of Pharmaceutical Sciences & Research, Pushp Vihar, Sector 3, MB Road, New Delhi 110 017, India.
Gupta
S K
SK
Srivastava
Sushma
S
Agrawal
S S
SS
Saxena
Rohit
R
D000818:Animals; D018552:Daucus carota / Q000737:chemistry*; D005123:Eye / Q000187:drug effects; D007429:Intraocular Pressure / Q000187:drug effects*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D011817:Rabbits; D012639:Seeds / Q000737:chemistry*
D010936:Plant Extracts