title: Investigation of interaction between DCDC2 and KIAA0319 in a large German dyslexia sample.
abstract: The dyslexia susceptibility locus DYX2 (chr. 6p21-p22) harbours two candidate genes, DCDC2 and KIAA0319. In 2006, Harold et al. reported evidence for interaction between both genes. Having previously identified a risk haplotype for dyslexia in DCDC2, but not KIAA0319, in German families, we also tested for interaction between this risk haplotype and KIAA0319. We found a nominally significant association for the quantitative dimension "word reading", the core phenotype in the study of Harold et al., which may be considered as supportive evidence.
authors.affiliation: Department of Genomics, Life and Brain Center, University of Bonn, Sigmund-Freud Str. 25, 53105, Bonn, Germany.
authors.forename: Kerstin U
authors.initials: KU
authors.lastname: Ludwig
authors.forename: Darina
authors.initials: D
authors.lastname: Roeske
authors.forename: Johannes
authors.initials: J
authors.lastname: Schumacher
authors.forename: Gerd
authors.initials: G
authors.lastname: Schulte-Körne
authors.forename: Inke R
authors.initials: IR
authors.lastname: König
authors.forename: Andreas
authors.initials: A
authors.lastname: Warnke
authors.forename: Ellen
authors.initials: E
authors.lastname: Plume
authors.forename: Andreas
authors.initials: A
authors.lastname: Ziegler
authors.forename: Helmut
authors.initials: H
authors.lastname: Remschmidt
authors.forename: Bertram
authors.initials: B
authors.lastname: Müller-Myhsok
authors.forename: Markus M
authors.initials: MM
authors.lastname: Nöthen
authors.forename: Per
authors.initials: P
authors.lastname: Hoffmann
mesh_terms: D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D004410:Dyslexia / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology*; D005858:Germany / Q000453:epidemiology; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008869:Microtubule-Associated Proteins / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D011932:Reading
chemical_list: C510451:DCDC2 protein, human; C500377:KIAA0319 protein, human; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins