Mitochondria and L-lactate metabolism.
Although mitochondria have been the object of intensive study over many decades, some aspects of their metabolism remain to be fully elucidated, including the L-lactate metabolism. We review here the novel insights arisen from investigations on L-lactate metabolism in mammalian, plant and yeast mitochondria. The presence of L-lactate dehydrogenases inside mitochondria, where L-lactate enters in a carrier-mediated fashion, suggests that mitochondria play an important role in L-lactate metabolism. Functional studies have demonstrated the occurrence of several L-lactate carriers. Moreover, immunological investigations have proven the existence of monocarboxylate translocator isoforms in mitochondria.
Passarella
Salvatore
S
Dipartimento di Scienze per la Salute, Università del Molise, Via De Sanctis I-86100 Campobasso, Italy.
de Bari
Lidia
L
Valenti
Daniela
D
Pizzuto
Roberto
R
Paventi
Gianluca
G
Atlante
Anna
A
D000818:Animals; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism*; D008297:Male; D051379:Mice; D008928:Mitochondria / Q000378:metabolism*; D010944:Plants / Q000378:metabolism / Q000648:ultrastructure; D015003:Yeasts / Q000378:metabolism / Q000648:ultrastructure
D019344:Lactic Acid