title: A new reversible ischemic neurologic deficit model in dogs.
abstract: BACKGROUND
  The aim of this study was to produce an internal carotid artery (ICA) occlusion model in dogs that can be used for studying the effects of surgical revascularization procedures.
  
  
  METHODS
  After left frontoparietal craniectomy, the ICA and arterial circle of the brain were coagulated and transected, letting the middle cerebral artery be perfused by the contralateral ICA by way of the rostral cerebral artery in five mongrel dogs. Magnetic resonance imaging (MRI) and brain single-photon emission computed tomography (SPECT) were performed during the first 24 to 48 hours and 7 to 10 days after the operation. Paired t and Wilcoxon matched pair tests were used for statistics (p<0.05).
  
  
  RESULTS
  All the dogs had postoperative hemiparesis that returned to normal after 7 to 10 days. Early MRI showed cerebral ischemia in the left parietal cortical area extending to the subcortical white matter, sparing the basal ganglion and the internal capsule. Early brain SPECT demonstrated hypoperfusion corresponding to the same area. This area became significantly restricted to a small cortical area in late MRI and SPECT images (p<0.05).
  
  
  CONCLUSIONS
  It is concluded that, as symptoms resolved spontaneously, this model can be used as a "reversible ischemic neurological deficit" model for diagnostic imaging and pharmacological studies.
authors.affiliation: Department of Anesthesiology and Intensive Care, Faculty of Medicine, Selcuk University, Konya, Turkey. coztin@hotmail.com
authors.forename: Cemile Oztin
authors.initials: CO
authors.lastname: Ogün
authors.forename: Güngör
authors.initials: G
authors.lastname: Taştekin
authors.forename: Demet
authors.initials: D
authors.lastname: Kireşi
authors.forename: Olcay
authors.initials: O
authors.lastname: Eser
authors.forename: Mehmet Erkan
authors.initials: ME
authors.lastname: Ustün
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D002343:Carotid Artery, Internal / Q000473:pathology*; D002560:Cerebrovascular Circulation; D004195:Disease Models, Animal; D004285:Dogs; D008279:Magnetic Resonance Imaging; D009422:Nervous System Diseases / Q000209:etiology / Q000503:physiopathology*; D012039:Regional Blood Flow; D015899:Tomography, Emission-Computed, Single-Photon