title: A selective colorimetric chemosensor for thiols based on intramolecular charge transfer mechanism.
abstract: Compound 1 as an electron donor-acceptor compound with N,N-dimethylaniline and quinone units was designed for a highly selective colorimetric determination of thiol-containing amino acids and peptides, by making use of the unique reactivity of thiol towards quinone. Compound 1 shows a strong intramolecular charge transfer (ICT) band around 582nm; but, it decreased after addition of either cysteine (Cys) or glutathione (GSH). Moreover, the ICT band intensity at 582nm decreased linearly with the increasing concentrations of Cys or GSH. The interference from other amino acids can be neglected. Therefore, compound 1 can be employed as a selective colorimetric visual chemosensor for thiol-containing amino acids and peptides.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Organic Solids Laboratory, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zeng
authors.forename: Guanxin
authors.initials: G
authors.lastname: Zhang
authors.forename: Deqing
authors.initials: D
authors.lastname: Zhang
mesh_terms: D015374:Biosensing Techniques; D003124:Colorimetry / Q000379:methods*; D003545:Cysteine / Q000737:chemistry*; D005978:Glutathione / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: D005978:Glutathione; D003545:Cysteine