title: KRAS mutations: an old oncogene becomes a new predictive biomarker.
abstract: This commentary highlights a novel assay for detection of mutations in KRAS, which have recently emerged as a useful negative predictive biomarker.
authors.affiliation: Thoracic Oncology Service, Department of Medicine, New York, New York, USA.
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Riely
authors.forename: Marc
authors.initials: M
authors.lastname: Ladanyi
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D066246:ErbB Receptors / Q000235:genetics / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D009857:Oncogenes; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D016283:Proto-Oncogene Proteins p21(ras); D018631:ras Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D015415:Biomarkers; C117307:KRAS protein, human; D011518:Proto-Oncogene Proteins; D066246:ErbB Receptors; D016283:Proto-Oncogene Proteins p21(ras); D018631:ras Proteins