Origins of the double asymmetric induction on proline-catalyzed aldol reactions.
Computational studies to elucidate the origin of the double asymmetric induction on proline-catalyzed aldol reaction have been performed using HF/6-31G(d) calculations. The computed transition structures explain the experimental data obtained.
Calderón
Félix
F
Instituto de Química Orgánica General, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain.
Doyagüez
Elisa G
EG
Cheong
Paul Ha-Yeon
PH
Fernández-Mayoralas
Alfonso
A
Houk
K N
KN
D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D007659:Ketones / Q000737:chemistry; D011392:Proline / Q000737:chemistry*; D013237:Stereoisomerism
D000447:Aldehydes; D007659:Ketones; C116609:3-hydroxybutanal; D011392:Proline