title: Comparison of liver biopsy and transient elastography based on clinical relevance.
abstract: BACKGROUND
  Liver stiffness measurement (LSM) by transient elastography has recently been validated for the evaluation of liver fibrosis in chronic liver diseases. The present study focused on cases in which liver biopsy and LSM were discordant.
  
  
  METHODS
  Three hundred eighty-six patients with chronic hepatitis C who underwent a liver biopsy between December 2004 and April 2007 were studied. First, the optimal cut-off value of LSM was selected for the determination of cirrhosis based on the receiver operating characteristic curve. Then, the cases in which liver histology and evaluation by LSM were discordant were selected. Laboratory test results such as serum total bilirubin concentration, prothrombin activity, albumin concentration, platelet count and the aspartate aminotransferase to platelet ratio index, together with the presence of esophageal varices, were analyzed.
  
  
  RESULTS
  The optimal cut-off value was chosen to be 15.9 kPa for cirrhosis (fibrosis stage [F] 4) determination to maximize the sum of sensitivity (78.9%) and specificity (81.0%). There were 78 discordant cases: 51 patients showed an LSM of 15.9 kPa or higher and a fibrosis stage of F1 to F3 (high LSM group), and 27 patients had an LSM lower than 15.9 kPa and a fibrosis stage of F4 (low LSM group). Esophageal varices were seen in 11 patients in the high LSM group (n=51) and in no patients in the low LSM group (n=27) (P=0.0012). The aspartate aminotransferase to platelet ratio index was significantly higher in the high LSM group (1.49 versus 0.89, P=0.019). Other parameters did not differ significantly. However, platelet count, prothrombin activity and albumin concentration tended to be lower in the high LSM group.
  
  
  CONCLUSIONS
  Patients with a high LSM need proper attention for cirrhosis, even if liver biopsy does not reveal cirrhosis.
authors.affiliation: Department of Gastroenterology, University of Tokyo, Bunkyo-ku, Tokyo, Japan.
authors.forename: Ryota
authors.initials: R
authors.lastname: Masuzaki
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Tateishi
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Yoshida
authors.forename: Erik
authors.initials: E
authors.lastname: Goto
authors.forename: Takahisa
authors.initials: T
authors.lastname: Sato
authors.forename: Takamasa
authors.initials: T
authors.lastname: Ohki
authors.forename: Tadashi
authors.initials: T
authors.lastname: Goto
authors.forename: Hideo
authors.initials: H
authors.lastname: Yoshida
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Kanai
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Sugioka
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ikeda
authors.forename: Shuichiro
authors.initials: S
authors.lastname: Shiina
authors.forename: Takao
authors.initials: T
authors.lastname: Kawabe
authors.forename: Masao
authors.initials: M
authors.lastname: Omata
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D054459:Elasticity Imaging Techniques; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications / Q000473:pathology*; D006801:Humans; D008103:Liver Cirrhosis / Q000473:pathology* / Q000821:virology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012372:ROC Curve; D012720:Severity of Illness Index