[Update on vitamin D and evaluation of vitamin D status].
Knowledge about vitamin D has greatly improved during the last few years. Vitamin D cannot any more be considered as exclusively necessary to prevent ricket/osteomalacia. Its role in the prevention of some osteoporotic fractures in the elderly (in association with calcium nutrition) is now well demonstrated and many epidemiologic and laboratory data argue for a role in the prevention of several diseases or anomalies (cancer, auto-immune diseases, cardiovascular events, sarcopenia...). A few intervention studies confirming some of these effects also exist. Vitamin D status can easily be assessed by measuring serum 25 hydroxy vitamin D (25OHD) level. However, many experts have claimed that the population-based reference values for 25OHD are too low and that the cut-off value below which vitamin D insufficiency can be present is somewhere between 20 and 40 ng/mL with a clear tendency to target values above 30 ng/mL (75 nmol/L). The main consequences are that vitamin D insufficiency is highly frequent whereas the currently recommended supplementation doses are not sufficient.
Souberbielle
J-C
JC
Service d'Explorations Fonctionnelles, Hôpital Necker-Enfants-malades, Paris, France. jean-claude.souberbielle@nck.ap-hop-paris.fr
Prié
D
D
Courbebaisse
M
M
Friedlander
G
G
Houillier
P
P
Maruani
G
G
Cavalier
E
E
Cormier
C
C
D000818:Animals; D006801:Humans; D007107:Immune System / Q000502:physiology; D018482:Muscle, Skeletal / Q000502:physiology; D009369:Neoplasms / Q000503:physiopathology; D009752:Nutritional Status / Q000502:physiology; D014807:Vitamin D / Q000097:blood / Q000502:physiology*; D014808:Vitamin D Deficiency / Q000175:diagnosis*; D014815:Vitamins / Q000502:physiology*
D014815:Vitamins; D014807:Vitamin D