title: Onchocerciasis control: biological research is still needed.
abstract: Achievements obtained by the onchocerciasis control programmes should not lead to a relaxation in the biological research on Onchocerco volvulus. Issues such as the Loa loa-related post-ivermectin serious adverse events, the uncertainties as to whether onchocerciasis can be eliminated by ivermectin treatments, and the possible emergence of ivermectin-resistant O. volvulus populations should be addressed proactively. Doxycycline, moxidectin and emodepside appear to be promising as alternative drugs against onchocerciasis but support to researches in immunology and genomics should also be increased to develop new control tools, including both vaccines and macrofilaricidal drugs.
authors.affiliation: Institut de Recherche pour le Développement, UR-024, 911, avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France. boussinesq@ird.fr
authors.forename: M
authors.initials: M
authors.lastname: Boussinesq
mesh_terms: D000818:Animals; D004351:Drug Resistance; D005369:Filaricides / Q000627:therapeutic use*; D006801:Humans; D007300:Insect Control / Q000379:methods*; D007303:Insect Vectors / Q000469:parasitology*; D007559:Ivermectin / Q000627:therapeutic use; D017181:Onchocerca volvulus; D009855:Onchocerciasis / Q000188:drug therapy / Q000517:prevention & control* / Q000635:transmission / Q000662:veterinary; D016896:Treatment Outcome; D014611:Vaccination
chemical_list: D005369:Filaricides; D007559:Ivermectin