[Induced acute non-lymphoblastic leukemia and prognostic significance of cytogenetic abnormalities: trisomy in chromosome 8, inv(16)(p13q22), and t(8;21)(q22;q22)].
3 patients with secondary acute non-lymphoblastic leucosis have been observed. The cytogenetic analysis revealed pathologic karyotypes: 46, XY,+8, t(8;21), inv 16. Two patients have been found with typical markers of damaged chromosome of radiation origion. Insensibility of blastic cells to cytostatic therapy was typical for the patients.
Tretiak
N M
NM
Vakul'chuk
O M
OM
Kalinina
S Iu
SIu
D000328:Adult; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics* / Q000528:radiation effects; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D016609:Neoplasms, Second Primary / Q000235:genetics*; D011379:Prognosis; D014314:Trisomy