title: Tyrianthinic acids from Ipomoea tyrianthina and their antimycobacterial activity, cytotoxicity, and effects on the central nervous system.
abstract: Four new partially acylated tetrasaccharides of 11-hydroxyhexadecanoic acid (1-4) were isolated from a methanolic extract of Ipomoea tyrianthina. The structures of these compounds were elucidated by spectroscopic and chemical methods. The resin glycoside composition of I. tyrianthina varied with the location of growth in Mexico. Compounds 1-4 showed antimycobacterial activity, were cytotoxic against the KB cell line, and, in a mouse model, exhibited potentiation of hypnosis induced by pentobarbital, protected against seizures induced by pentylenetetrazole, and released GABA and glutamic acid.
authors.affiliation: Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, Mexico. ismaelr@ciq.uaem.mx
authors.forename: Ismael
authors.initials: I
authors.lastname: León-Rivera
authors.forename: Gumersindo
authors.initials: G
authors.lastname: Mirón-López
authors.forename: Gloria María
authors.initials: GM
authors.lastname: Molina-Salinas
authors.forename: Maribel
authors.initials: M
authors.lastname: Herrera-Ruiz
authors.forename: Samuel
authors.initials: S
authors.lastname: Estrada-Soto
authors.forename: María
authors.initials: M
authors.lastname: del Carmen Gutiérrez
authors.forename: Daniel
authors.initials: D
authors.lastname: Alonso-Cortes
authors.forename: Gabriel
authors.initials: G
authors.lastname: Navarrete-Vázquez
authors.forename: María Yolanda
authors.initials: MY
authors.lastname: Ríos
authors.forename: Salvador
authors.initials: S
authors.lastname: Said-Fernández
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002490:Central Nervous System / Q000187:drug effects*; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D027741:Ipomoea / Q000737:chemistry*; D007624:KB Cells; D008800:Mexico; D051379:Mice; D023421:Models, Animal; D009844:Oligosaccharides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D010424:Pentobarbital / Q000494:pharmacology; D010433:Pentylenetetrazole / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014376:Tuberculosis / Q000188:drug therapy*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000995:Antitubercular Agents; D009844:Oligosaccharides; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D010424:Pentobarbital; D010433:Pentylenetetrazole