title: Immediate latissimus dorsi miniflap volume replacement for partial mastectomy: use of intra-operative frozen sections to confirm negative margins.
abstract: BACKGROUND
  Latissimus dorsi (LD) miniflap volume replacement is used for immediate reconstruction after partial mastectomy. This prospectively collected series was analyzed to evaluate the accuracy of intraoperative frozen sections.
  
  
  METHODS
  After partial mastectomy, "bed biopsies" were submitted for intraoperative frozen-section analysis. If disease free, volume replacement was undertaken; if involved, targeted re-excisions were taken. Demographic, pathological, and outcome data were recorded. The proportion of breast excised was calculated. Local recurrences were recorded.
  
  
  RESULTS
  One hundred ten partial mastectomies with LD miniflap volume replacement were completed. The median proportion of breast excised was 28% (maximum 72%); median weight 207 g. Frozen sections were positive in 33% of patients with a sensitivity of 83% and accuracy of 96% when compared with paraffin sections. Local recurrence occurred in one case. The median follow-up was 41.4 months.
  
  
  CONCLUSIONS
  LD miniflap volume replacement extends the role of breast-conserving surgery. Frozen-section analysis of bed biopsies facilitates a single-stage procedure.
authors.affiliation: The Winchester Breast Unit, Royal Hampshire County Hospital, Romsey Road, Winchester SO22 5DG, UK.
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Rusby
authors.forename: Nirmala
authors.initials: N
authors.lastname: Paramanathan
authors.forename: Siobhan A M
authors.initials: SA
authors.lastname: Laws
authors.forename: Richard M
authors.initials: RM
authors.lastname: Rainsbury
mesh_terms: D001706:Biopsy; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005629:Frozen Sections; D006801:Humans; D016462:Mammaplasty / Q000379:methods*; D015412:Mastectomy, Segmental; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000601:surgery*; D009364:Neoplasm Recurrence, Local; D011446:Prospective Studies; D013524:Surgical Flaps; D016896:Treatment Outcome