title: Therapeutic effect of ARBs on insulin resistance and liver injury in patients with NAFLD and chronic hepatitis C: a pilot study.
abstract: Fatty liver is one of the local morphological manifestations of metabolic syndrome and is frequently associated with insulin resistance. Insulin resistance is also common in patients with chronic hepatitis C. Hyperinsulinemia is an independent risk factor for hypertension and cardiovascular mortality. The aim of this study was to evaluate the therapeutic efficacy of angiotensin II receptor blockers (ARBs), telmisartan and olmesartan, for patients with non-alcoholic fatty liver disease (NAFLD) and chronic hepatitis C (CH-C). We analyzed the incidence of obesity, insulin resistance, and other disorders in patients with NAFLD (Group A), CH-C (Group B), or other liver diseases (Group C). We evaluated whether the ARBs, telmisartan and olmesartan, improved insulin resistance and liver injury by measuring the homeostasis model assessment ratio of insulin resistance (HOMA-IR) and serum alanine aminotransferase (ALT). The incidence of obesity (BMI > or =25 kg/m2) was significantly higher in Group A than in Groups B and C. The incidence of insulin resistance (HOMA-IR > or =2.5) in Groups A and B was significantly higher than in Group C. Regular doses of telmisartan and olmesartan significantly improved HOMA-IR and ALT levels not only in NAFLD patients but also in patients with CH-C. The effects tended to be more notable with telmisartan. In conclusion, telmisartan and olmesartan improved insulin sensitivity and may possibly be used as liver protecting agents in CH-C as well as NAFLD patients.
authors.affiliation: Department of Clinical Pharmacology, Fukuoka University, Fukuoka 814-0180, Japan. enjoji@adm.fukuoka-u.ac.jp
authors.forename: Munechika
authors.initials: M
authors.lastname: Enjoji
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kotoh
authors.forename: Masaki
authors.initials: M
authors.lastname: Kato
authors.forename: Nobito
authors.initials: N
authors.lastname: Higuchi
authors.forename: Motoyuki
authors.initials: M
authors.lastname: Kohjima
authors.forename: Manabu
authors.initials: M
authors.lastname: Nakashima
authors.forename: Makoto
authors.initials: M
authors.lastname: Nakamuta
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000410:Alanine Transaminase / Q000097:blood; D001562:Benzimidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D001565:Benzoates / Q000008:administration & dosage / Q000627:therapeutic use*; D005234:Fatty Liver / Q000097:blood / Q000150:complications* / Q000188:drug therapy* / Q000453:epidemiology; D005260:Female; D019698:Hepatitis C, Chronic / Q000097:blood / Q000150:complications* / Q000188:drug therapy* / Q000453:epidemiology; D006706:Homeostasis; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy; D007093:Imidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D015994:Incidence; D007333:Insulin Resistance; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D000077333:Telmisartan; D013777:Tetrazoles / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D001562:Benzimidazoles; D001565:Benzoates; D007093:Imidazoles; D013777:Tetrazoles; C437965:olmesartan; D000410:Alanine Transaminase; D000077333:Telmisartan