[Sexual distinctions of the diazepam activity in rats in the conflict situation].
Diazepam caused less pronounced shifts in the conflict situation test in female rats as compared to males. The drug produced more pronounced anticonflict action on male rats in the evening. In female rats, a doze of 0.5 mg/kg of the anxiolytic drug produced a clear anticonflict action, mostly in the evening; however, even this effect was approximately only about half of that observed in males in the same period of time.
Manvelian
E A
EA
Baturin
V A
VA
D000204:Activity Cycles; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D003220:Conflict, Psychological; D003975:Diazepam / Q000494:pharmacology*; D004327:Drinking Behavior / Q000187:drug effects*; D005260:Female; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D012737:Sex Factors
D014151:Anti-Anxiety Agents; D003975:Diazepam