title: Nhlh2: a basic helix-loop-helix transcription factor controlling physical activity.
abstract: In mice, targeted deletion of the basic helix-loop-helix transcription factor, nescient helix-loop-helix 2 (Nhlh2), leads to adult-onset obesity and reduced physical activity. We propose the novel hypothesis that transcriptional activity by Nhlh2 (NHLH2 in humans) controls either the ability or the motivation for exercise.
authors.affiliation: Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, USA. goodd@vt.edu
authors.forename: Deborah J
authors.initials: DJ
authors.lastname: Good
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Coyle
authors.forename: Dana L
authors.initials: DL
authors.lastname: Fox
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics* / Q000378:metabolism; D017353:Gene Deletion; D008040:Genetic Linkage; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D009042:Motivation; D009043:Motor Activity / Q000235:genetics*; D009765:Obesity / Q000235:genetics; D014157:Transcription Factors / Q000172:deficiency / Q000235:genetics / Q000378:metabolism
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D014157:Transcription Factors; C076747:NHLH2 protein, human