Saccharomyces kluyveri as a model organism to study pyrimidine degradation.
The yeast Saccharomyces kluyveri (Lachancea kluyveri), a far relative of Saccharomyces cerevisiae, is not a widely studied organism in the laboratory. However, significant contributions to the understanding of nucleic acid precursors degradation in eukaryotes have been made using this model organism. Here we review eukaryotic pyrimidine degradation with emphasis on the contributions made with S. kluyveri and how this increases our understanding of human disease. Additionally, we discuss the possibilities and limitations of this nonconventional yeast as a laboratory organism.
Beck
Halfdan
H
Department of Cell and Organism Biology, Lund University, Lund, Sweden.
Dobritzsch
Doreen
D
Piskur
Jure
J
D000581:Amidohydrolases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D000818:Animals; D005057:Eukaryotic Cells / Q000378:metabolism*; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D009694:Nucleic Acid Precursors / Q000378:metabolism*; D011743:Pyrimidines / Q000378:metabolism*; D012440:Saccharomyces / Q000145:classification* / Q000201:enzymology* / Q000235:genetics / Q000378:metabolism
D005656:Fungal Proteins; D009694:Nucleic Acid Precursors; D011743:Pyrimidines; D000581:Amidohydrolases; C021590:beta-ureidopropionase; C020047:dihydropyrimidinase; C030986:pyrimidine