title: [Antidepressive therapy - dosing recommendations at beginning and end of treatment].
abstract: The knowledge of diagnostic procedures and therapy of depressive disorders is very important for every physician because of the high incidence of the disease. Particularly with regard to the critical phases of therapy, onset and discontinuation of antidepressive medication, a close contact between patient and physician is needed to identify adverse effects of the medication and withdrawal phenomena. The following article reviews current antidepressants and recommendations for starting and stopping antidepressive therapy mainly based on clinical experience because only limited evidence-based treatment schedules are available.
authors.affiliation: Zentrum für Psychosoziale Medizin, Psychiatrische Universitätsklinik Heidelberg. sara.bienentreu@med.uni-heidelberg.de
authors.forename: Sara
authors.initials: S
authors.lastname: Bienentreu
authors.forename: Sonja
authors.initials: S
authors.lastname: Külkens
authors.forename: Christoph
authors.initials: C
authors.lastname: Mundt
mesh_terms: D000928:Antidepressive Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D001711:Biotransformation; D000075202:Contraindications; D003866:Depressive Disorder / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D008657:Metabolic Clearance Rate; D012017:Referral and Consultation; D013375:Substance Withdrawal Syndrome / Q000097:blood / Q000175:diagnosis / Q000517:prevention & control*
chemical_list: D000928:Antidepressive Agents