title: The relationship between regional body composition and quantitative strength in facioscapulohumeral muscular dystrophy (FSHD).
abstract: This study determines in facioscapulohumeral muscular dystrophy (FSHD) and able-bodied controls (1) the regional body composition and (2) the correlation between regional lean tissue mass and the corresponding regional strength. This is a cross-sectional, criterion standard, case-control study at a university based neuromuscular disease clinic. A dual-energy X-ray absorptiometry (DEXA) scanner was used to obtain regional body composition measurements in 14 FSHD and anthropometrically matched control pairs. A dynamometer determined peak isometric strength for the elbow and knee. Compared to controls, FSHD subjects showed increased regional fat tissue mass (p < 0.001-0.017), decreased regional lean tissue mass (p < 0.001-0.010), and decreased strength (p < 0.001-0.020). There was a correlation between quantitative strength and lean tissue mass for both FSHD and controls (r = 0.791-0.906; p < 0.001). FSHD subjects have higher regional fat tissue mass and lower regional lean tissue mass despite similar BMI and anthropometrics. Regional lean tissue mass correlates with strength.
authors.affiliation: Department of Physical Medicine and Rehabilitation, University of California, Davis, 4860 Y Street, Suite 3850, Sacramento, CA 95817, USA. andrew.skalsky@ucdmc.ucdavis.edu
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Skalsky
authors.forename: Richard T
authors.initials: RT
authors.lastname: Abresch
authors.forename: Jay J
authors.initials: JJ
authors.lastname: Han
authors.forename: Chris S
authors.initials: CS
authors.lastname: Shin
authors.forename: Craig M
authors.initials: CM
authors.lastname: McDonald
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods*; D000273:Adipose Tissue / Q000378:metabolism; D050154:Adiposity / Q000502:physiology; D000293:Adolescent; D000328:Adult; D000886:Anthropometry / Q000379:methods; D001823:Body Composition / Q000502:physiology*; D015519:Bone Density / Q000502:physiology; D016022:Case-Control Studies; D002648:Child; D003430:Cross-Sectional Studies; D004551:Elbow Joint / Q000502:physiology; D005260:Female; D006801:Humans; D007537:Isometric Contraction / Q000502:physiology; D007719:Knee Joint / Q000502:physiology; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology; D020391:Muscular Dystrophy, Facioscapulohumeral / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology*; D055815:Young Adult