title: Dynamic selection of novel vancomycin N-terminal derivatives by resin-bound reversed D-Ala-D-Ala.
abstract: The most attractive advantage of dynamic combinatorial chemistry (DCC) is that it can screen the compound library as soon as compounds are synthesized. However, it is very difficult to analyze a dynamic combinatorial library with free probes using the state-of-the art analysis technologies. We report herein a method that uses a resin-immobilizing reversed peptide probe to screen vancomycin derivatives and provides a solution to this problem.
authors.affiliation: Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Materia Medica, 2 Nanwei Road, Xuanwu District, Beijing 100050, P. R. China.
authors.forename: Yu-Yan
authors.initials: YY
authors.lastname: Chen
authors.forename: Wen-Yi
authors.initials: WY
authors.lastname: He
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.forename: Chang-Qun
authors.initials: CQ
authors.lastname: Niu
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D004151:Dipeptides / Q000737:chemistry*; D055808:Drug Discovery / Q000379:methods*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D012117:Resins, Synthetic; D054852:Small Molecule Libraries; D014640:Vancomycin / Q000031:analogs & derivatives*
chemical_list: D004151:Dipeptides; D012117:Resins, Synthetic; D054852:Small Molecule Libraries; C002956:alanylalanine; D014640:Vancomycin