Role for Porphyromonas gingivalis in the progression of atherosclerosis.
An association between atherosclerosis and Porphyromonas gingivalis (P. gingivalis), a major periodontopathogen, has been shown. However, the question of whether this relationship is causal or coincidental still exist. Many individuals with evidence of atherosclerosis demonstrate seropositivity to this pathogen. Both in vitro studies and in animal models document that P. gingivalis can accelerate atheroma deposition. Recently, evidence from diverse sources has suggested P. gingivalis can activate host innate immune responses associated with atherosclerosis. These studies confirm that the inflammatory response to P. gingivalis could exacerbate vascular inflammation via secreted cytokines and/or chemokines that ultimately modulate early atherogenesis that spontaneously develop atherosclerosis. Meanwhile, the cytokine and chemokines interact in the progression of atherosclerosis. Moreover, the reaction of endothelial cells in response to P. gingivalis and its various virulence factors are diverse, the expression of chemokine differ through different signal transduction pathways accordingly. Results from these studies reinforce the connection between P. gingivalis and atherosclerosis. Given the role of P. gingivalis in the initiation and progression of atherosclerosis, attaching importance to periodontal disease may offer new therapeutic options for the management of patients with atherosclerosis.
Wang
Qian
Q
The Department of Endodontics, West China College of Stomatology, Sichuan University, No. 14, Third Section, Renmin Nan Road, Chengdu 610041, China.
Zhou
Xuedong
X
Huang
Dingming
D
D050197:Atherosclerosis / Q000150:complications / Q000382:microbiology* / Q000503:physiopathology*; D018450:Disease Progression; D004730:Endothelium, Vascular / Q000382:microbiology; D006801:Humans; D007249:Inflammation / Q000382:microbiology / Q000503:physiopathology; D010510:Periodontal Diseases / Q000453:epidemiology / Q000382:microbiology; D016966:Porphyromonas gingivalis / Q000472:pathogenicity*