Compartment model of neuropeptide synaptic transport with impulse control.
In this paper a mathematical description of a presynaptic episode of slow synaptic neuropeptide transport is proposed. Two interrelated mathematical models, one based on a system of reaction diffusion partial differential equations and another one, a compartment type, based on a system of ordinary differential equations (ODE) are formulated. Processes of inflow, calcium triggered activation, diffusion and release of neuropeptide from large dense core vesicles (LDCV) as well as inflow and diffusion of ionic calcium are represented. The models assume the space constraints on the motion of inactive LDCVs and free diffusion of activated ones and ions of calcium. Numerical simulations for the ODE model are presented as well. Additionally, an electronic circuit, reflecting the functional properties of the mathematically modelled presynaptic slow transport processes, is introduced.
Bielecki
Andrzej
A
Institute of Computer Science, Jagiellonian University, Nawojki 11, 30-072, Kraków, Poland. bielecki@softlab.ii.uj.edu.pl
Kalita
Piotr
P
Lewandowski
Marian
M
Skomorowski
Marek
M
D000465:Algorithms; D000818:Animals; D001370:Axonal Transport / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling / Q000502:physiology; D002451:Cell Compartmentation / Q000502:physiology; D003198:Computer Simulation; D004058:Diffusion; D006801:Humans; D008959:Models, Neurological; D009420:Nervous System / Q000378:metabolism*; D009479:Neuropeptides / Q000378:metabolism*; D017729:Presynaptic Terminals / Q000378:metabolism*; D022142:Secretory Vesicles / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology*
D009479:Neuropeptides; D002118:Calcium