Epstein-Barr virus load in cerebrospinal fluid of patients with chronic active Epstein-Barr virus infection.
Chronic active Epstein-Barr virus (EBV) infection is a rare chronic mononucleosis syndrome involving clonally proliferating EBV-infected T-/NK-cells. EBV DNA was quantified in nonpleocytotic cerebrospinal fluid (CSF) of 9 patients. Three patients with neurologic and/or neuroimaging abnormalities showed high CSF copy numbers. In 1 patient, CSF copy number exceeded the peripheral blood value. CSF EBV-load may predict the central nervous system involvement of EBVT-/NK-cells.
Ohga
Shouichi
S
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. ohgas@pediatr.med.kyushu-u.ac.jp
Sanefuji
Masafumi
M
Ishimura
Masataka
M
Nomura
Akihiko
A
Torisu
Hiroyuki
H
Kira
Ryutaro
R
Takada
Hidetoshi
H
Mizuno
Yumi
Y
Kazuyama
Yukumasa
Y
Hara
Toshiro
T
D000293:Adolescent; D000328:Adult; D002555:Cerebrospinal Fluid / Q000821:virology*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D006801:Humans; D007244:Infectious Mononucleosis / Q000134:cerebrospinal fluid / Q000821:virology*; D007694:Killer Cells, Natural; D008279:Magnetic Resonance Imaging; D008297:Male; D016133:Polymerase Chain Reaction; D013601:T-Lymphocytes; D019562:Viral Load