Rhodium catalyzed 1,4-conjugate addition of 1,5-azastibocines with electron deficient olefins.
The rhodium-catalyzed reaction of Sb-aryl-1,5-azastibocines with alpha,beta-unsaturated ketones and esters is described. Exclusive formation of 1,4-conjugate adduct was achieved in aqueous NMP (N-methyl-2-pyrrolidinone) in the presence of 5 mol% of [RhCl(cod)](2), and no formation of Heck adduct was observed in this condition. Reactions with various enones and enoates were also demonstrated to prove generality of the 1,4-conjugate addition.
Kakusawa
Naoki
N
Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan.
Kurita
Jyoji
J
D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D004583:Electrons; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis*; D007659:Ketones / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*
D000475:Alkenes; D006576:Heterocyclic Compounds, 4 or More Rings; D007659:Ketones; D012238:Rhodium