title: Biodegradable poly(polyol sebacate) polymers.
abstract: We have developed a family of synthetic biodegradable polymers that are composed of structural units endogenous to the human metabolism, designated poly(polyol sebacate) (PPS) polymers. Material properties of PPS polymers can be tuned by altering the polyol monomer and reacting stiochiometric ratio of sebacic acid. These thermoset networks exhibited tensile Young's moduli ranging from 0.37+/-0.08 to 378+/-33 MPa with maximum elongations at break from 10.90+/-1.37% to 205.16+/-55.76%, and glass transition temperatures ranging from approximately 7-46 degrees C. In vitro degradation under physiological conditions was slower than in vivo degradation rates observed for some PPS polymers. PPS polymers demonstrated similar in vitro and in vivo biocompatibility compared to poly(L-lactic-co-glycolic acid) (PLGA).
authors.affiliation: Department of Chemical Engineering, Massachusetts Institute of Technology, 45 Carleton Street, E25-342, Cambridge, MA 02139, USA.
authors.forename: Joost P
authors.initials: JP
authors.lastname: Bruggeman
authors.forename: Berend-Jan
authors.initials: BJ
authors.lastname: de Bruin
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Bettinger
authors.forename: Robert
authors.initials: R
authors.lastname: Langer
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000378:metabolism*; D002448:Cell Adhesion; D002460:Cell Line; D049109:Cell Proliferation; D003652:Decanoic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D005260:Female; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D020007:Implants, Experimental / Q000009:adverse effects; D007249:Inflammation; D009682:Magnetic Resonance Spectroscopy; D008422:Materials Testing; D008970:Molecular Weight; D018482:Muscle, Skeletal / Q000473:pathology; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D051381:Rats; D011917:Rats, Inbred Lew; D013718:Tensile Strength; D044366:Transition Temperature
chemical_list: D001672:Biocompatible Materials; D003652:Decanoic Acids; D011108:Polymers