title: [Comparative efficacy of different muscle relaxants in the rehabilitation of post-stroke patients with spasticity].
abstract: An influence of different muscle relaxants on muscle tone and functional rehabilitation has been studied in 360 post-stroke patients. Muscle tone has been assessed with the Ashworth scale and functional rehabilitation with Barthel, Lindmark and Scandinavian scales as well as the Merton & Sutton scale. Efficacy of muscle relaxants has been assessed by the 2 min. walking test. Moreover, we suggested a coefficient for calculating drug efficacy. The results of the study revealed that tolperisone was the most efficient in the treatment of post-stroke patients with spasticity. Tizanidine was also effective but to a lesser extent. Other drugs studied did not reveal any significant effect. Tolperisone had a good tolerability, the adverse effects in patients treated with this drug were registered more rarely compared to other ones.
authors.forename: V V
authors.initials: VV
authors.lastname: Koval'chuk
authors.forename: A A
authors.initials: AA
authors.lastname: Skoromets
authors.forename: I V
authors.initials: IV
authors.lastname: Vasil'eva
mesh_terms: D000328:Adult; D000368:Aged; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009125:Muscle Relaxants, Central / Q000627:therapeutic use*; D009128:Muscle Spasticity / Q000188:drug therapy* / Q000209:etiology*; D020521:Stroke / Q000150:complications*
chemical_list: D009125:Muscle Relaxants, Central