The co-occurrence of serologically proven myasthenia gravis and Miller Fisher/Guillain Barré overlap syndrome: a case report.
The co-occurrence of myasthenia gravis (MG) and Guillain Barré syndrome (GBS) is uncommon with a few reported cases in the literature. There is only one reported case of MG and Miller Fisher variant of GBS. We described an 84 year old Chinese woman with underlying seropositive myasthenia gravis (MG) who presented with ophthalmoplegia, areflexia and acute neuromuscular weakness. She was proved to have co-occurrence of MG and GBS/Miller Fisher overlap syndrome with positive anti-GQ1b antibody. The unusual finding in this patient raises an interesting question on their pathogenesis with the possibility that prior activation of the immune system may predispose the development of autoantibodies against other antigens within the same set of muscles.
Lau
Kwok Kwong
KK
Department of Medicine and Geriatrics, Princess Margaret Hospital, Kwai Chung, New Territories, Hong Kong. dominickklau@hotmail.com
Goh
Khean Jin
KJ
Lee
Han Chih Hencher
HC
Chan
Yuk Tat Eric
YT
Tan
Chong Tin
CT
D000369:Aged, 80 and over; D000906:Antibodies / Q000097:blood; D005260:Female; D005732:Gangliosides / Q000276:immunology; D020275:Guillain-Barre Syndrome / Q000150:complications* / Q000276:immunology*; D006801:Humans; D009157:Myasthenia Gravis / Q000150:complications* / Q000276:immunology*; D012698:Serologic Tests / Q000379:methods*
D000906:Antibodies; D005732:Gangliosides; C039129:GQ1b ganglioside