Ru3(CO)12-catalyzed reactions of catechols with alkynes: an atom-economic process for the synthesis of 2,2-disubstituted 1,3-benzodioxoles from the double addition of the O-H bond across a triple bond.
Ru3(CO)12 has been found to be the efficient catalyst for the addition reactions of catechols with both terminal and internal alkynes to selectively afford 2,2-disubstituted 1,3-benzodioxoles in good to high yields. The formation of 2,2-substituted 1,3-benzodioxoles results from the tandem addition of two O-H bonds of catechols to alkyne's triple bond.
Li
Ming
M
Department of Chemistry, Tsinghua University, Innovative Catalysis Program, Key Laboratory of Organic Optoelectronics & Molecular Engineering of Ministry of Education, Beijing 100084, China.
Hua
Ruimao
R
D000480:Alkynes / Q000737:chemistry*; D052117:Benzodioxoles / Q000138:chemical synthesis*; D002384:Catalysis; D002396:Catechols / Q000737:chemistry*; D012428:Ruthenium
D000480:Alkynes; D052117:Benzodioxoles; D002396:Catechols; D012428:Ruthenium