Functional adaptation to oxidative stress by memory T cells: an analysis of the role in the cardiovascular disease process.
T cells participate in combating infection and critically determine the outcomes in any given disease process. Impaired immune response occurs in a number disease processes such as in cancer and atherosclerosis although the underlying mechanisms are still not fully understood. This article gives an up-to-date review of T cells development and functional adaptation to pathophysiological stimuli and participation in the cardiovascular disease process. In addition, we have discussed the signaling pathways controlled by the microenvironment that determine T cells function and resultant type of immune response. We have also discussed in detail how oxidative stress is a key component of the micro environmental interaction.
Elahi
Maqsood M
MM
Wessex Cardiothoracic Centre, BUPA Hospital, Southampton, UK.
Matata
Bashir M
BM
D000818:Animals; D050197:Atherosclerosis / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory; D008213:Lymphocyte Activation; D051379:Mice; D018384:Oxidative Stress / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*