Efficient TCT-catalyzed synthesis of 1,5-benzodiazepine derivatives under mild conditions.
2,4,6-Trichloro-1,3,5-triazine (TCT) efficiently catalyzed the condensation reactions between 1,2-diamines and various enolizable ketones to afford 1,5-benzodiazepines in good to excellent yields. Simple and mild reaction conditions, the use of a cheap catalyst and easy workup and isolation are notable features of this method.
Kuo
Chun-Wei
CW
Department of Chemistry, National Taiwan Normal University, 88, Section 4, Tingchow Road, Taipei 116, Taiwan, ROC. cheyaocf@ntnu.edu.tw.
Wang
Chun-Chao
CC
Kavala
Veerababurao
V
Yao
Ching-Fa
CF
D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D007659:Ketones / Q000737:chemistry; D015394:Molecular Structure; D010655:Phenylenediamines / Q000737:chemistry; D013237:Stereoisomerism; D014227:Triazines / Q000737:chemistry*
D007659:Ketones; D010655:Phenylenediamines; D014227:Triazines; D001569:Benzodiazepines