title: [Significance of the examination of path between eosinophils in peripheral blood and marrow stem cells for evaluating the effect of hormone therapy in patients with allergic rhinitis].
abstract: OBJECTIVE
  By means of the detection of the numbers of CD34(+) cells and eosinophils (EOS), and the level of IL-5 in peripheral blood from normal controls and patients with allergic rhinitis pre- or post-treatment, the role of EOS-stem cells paths for treatment effect in allergic rhinitis (AR) was studied so as to find the convenient and quick indicators which could be used to evaluate the clinical therapeutic effect and adjust the methods of the hormone therapy.
  
  
  METHODS
  There were 2 groups. (1) experimental group: 44 patients, including 24 males and 20 females with a age range of 7 to 68 years old. The patients received the treatment of fluticasone spurt for four weeks. (2) CONTROL GROUP: 30 cases, from normal health examination. The EOS numbers, CD4(+) cell numbers and the IL-5 level were examined in control group as well as before and after therapy in experimental group.
  
  
  RESULTS
  The IL-5 level and CD numbers before therapy in experimental group were (88.25 +/- 33.47) ng/L, (9.24 +/- 2.15)/10(5), significantly higher than that after therapy and experimental group which were (44.34 +/- 16.32) ng/L, (6.31 +/- 1.83)/10(5) and (31.24 +/- 8.43) ng/L, (3.47 +/- 1.32)/10(5) respectively. The IL-5 level was positively correlated with the CD34(+) number pre-and post treatment in experimental group (r = 0.64, P <0.01; (r = 0.61, P <0.01). The EOS number was positively correlated with the level of IL-5 (r = 0.64, P <0.01).
  
  
  CONCLUSIONS
  IL-5 and CD34(+) cells can be regarded as indicators to evaluate the therapeutic effect. The EOS, CD34(+) cells and the level of IL-5 in the peripheral blood are correlated with the pathogenesis of AR, suggesting that there is a related path between the local nasal tissue of AR patients and the marrow.
authors.affiliation: Department of Otorhinalaryngology, Second Hospital of Shandong University, Jinan 250033, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Da-Liang
authors.initials: DL
authors.lastname: Zhang
authors.forename: Jing-Jie
authors.initials: JJ
authors.lastname: Zhao
authors.forename: Jun-Li
authors.initials: JL
authors.lastname: Liu
authors.forename: Xian-Liang
authors.initials: XL
authors.lastname: Fan
authors.forename: Cheng-Hao
authors.initials: CH
authors.lastname: Guo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000730:Androstadienes / Q000627:therapeutic use*; D018926:Anti-Allergic Agents / Q000627:therapeutic use*; D018952:Antigens, CD34 / Q000378:metabolism; D001854:Bone Marrow Cells; D016022:Case-Control Studies; D002648:Child; D004804:Eosinophils / Q000276:immunology*; D005260:Female; D000068298:Fluticasone; D006801:Humans; D015848:Interleukin-5 / Q000097:blood; D008297:Male; D008875:Middle Aged; D012221:Rhinitis, Allergic, Perennial / Q000097:blood* / Q000188:drug therapy*; D013234:Stem Cells; D055815:Young Adult
chemical_list: D000730:Androstadienes; D018926:Anti-Allergic Agents; D018952:Antigens, CD34; D015848:Interleukin-5; D000068298:Fluticasone