title: Neoadjuvant cisplatin and etoposide followed by radical hysterectomy for stage 1B-2B cervical cancer.
abstract: OBJECTIVE
  We aimed to determine the efficacy and feasibility of neoadjuvant chemotherapy (NACT) using cisplatin and etoposide in patients with locally advanced cervical cancer.
  
  
  METHODS
  Previously untreated patients with histologically confirmed stage 1B-2B cervical cancer were treated with three courses of NACT (60 mg/m2 cisplatin on days 1 and 2 plus 100 mg/m2 etoposide on day 1) every 10 days. NACT was followed within 2-3 weeks by radical hysterectomy with lymph node dissection.
  
  
  RESULTS
  From 1999 to 2004, 112 patients were enrolled and 99 patients were evaluable. All eligible patients had radical surgery after NACT. Hematologic toxicity was the most common side effect, and the level of toxicity was acceptable. The overall pathologic response rate was 69.7% (69/99). The median follow-up period was 49 months, and the 5-year overall and progression-free survival rates were 88.1% and 60.5%, respectively.
  
  
  CONCLUSIONS
  NACT with cisplatin and etoposide for patients with locally advanced cervical cancer is promising and has an acceptable toxicity profile. The regimen timing (every 10 days) did not delay the optimal time for radical treatment.
authors.affiliation: Department of Obstetrics and Gynecology, The Catholic University of Korea, Seoul, Korea.
authors.forename: Jeong-Hoon
authors.initials: JH
authors.lastname: Bae
authors.forename: Sung-Jong
authors.initials: SJ
authors.lastname: Lee
authors.forename: Ahwon
authors.initials: A
authors.lastname: Lee
authors.forename: Yong-Gyu
authors.initials: YG
authors.lastname: Park
authors.forename: Seog-Nyeon
authors.initials: SN
authors.lastname: Bae
authors.forename: Jong-Sup
authors.initials: JS
authors.lastname: Park
authors.forename: Sung-Eun
authors.initials: SE
authors.lastname: Namkoong
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D018572:Disease-Free Survival; D005047:Etoposide / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D055815:Young Adult
chemical_list: D005047:Etoposide; D002945:Cisplatin