Palladium-catalyzed direct arylation of nitro-substituted aromatics with aryl halides.
Direct arylation reactions of nitrobenzenes and aryl halides occur in good yield and high ortho regioselectivity. These reactions can be performed on gram scale with as few as 3 equiv of the nitro arene relative to the aryl halide. The synthetic utility of this method is demonstrated via rapid synthesis of a Boscalid intermediate.
Caron
Laurence
L
Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Canada K1N 6N5.
Campeau
Louis-Charles
LC
Fagnou
Keith
K
D002384:Catalysis; D006219:Halogens / Q000737:chemistry*; D015394:Molecular Structure; D009578:Nitrobenzenes / Q000737:chemistry; D017672:Nitrogen Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
D006219:Halogens; D009578:Nitrobenzenes; D017672:Nitrogen Compounds; D010165:Palladium; C036077:nitrobenzene