2-sulfonyliminodihydropyrimidines: a novel class of analgesic compounds.
A series of 2-sulfonyliminodihydropyrimidine derivatives have been synthesized and evaluated in vivo for their antinociceptive and anti-inflammatory activities. The results were compared with that of acetyl salicylic acid. Compounds 6Ab-d and 6Be displayed an interesting analgesic profile in the acetic acid-induced abdominal contractions test. Based on the results of the carrageenan-hind paw edema test, compound 6Af showed potential anti-inflammatory activity.
González-Rosende
M Eugenia
ME
Department of Physiology, Pharmacology and Toxicology, University CEU Cardenal Herrera, Moncada, Valencia, Spain. eugenia@uch.ceu.es
Olivar
Teresa
T
Castillo
Encarna
E
Sepúlveda-Arques
José
J
D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000517:prevention & control; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D015394:Molecular Structure; D010146:Pain / Q000517:prevention & control; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D011743:Pyrimidines