Catalytic chain-breaking pyridinol antioxidants.
When assayed for their capacity to inhibit azo-initiated peroxidation of linoleic acid in a water/chlorobenzene two-phase system, tellurium-containing 3-pyridinols were readily regenerable by N-acetylcysteine contained in the aqueous phase. The best inhibitors quenched peroxyl radicals more efficiently than alpha-tocopherol, and the duration of inhibition was limited only by the availability of the thiol reducing agent. The compounds were also found to catalyze reduction of hydrogen peroxide in the presence of thiol reducing agent.
Kumar
Sangit
S
Department of Biochemistry and Organic Chemistry, Uppsala University, Box 576, SE-75123 Uppsala, Sweden.
Johansson
Henrik
H
Kanda
Takahiro
T
Engman
Lars
L
Müller
Thomas
T
Jonsson
Mats
M
Pedulli
Gian Franco
GF
Petrucci
Silvia
S
Valgimigli
Luca
L