title: Obesity-related nephropathy associated with a history of IgA nephropathy.
abstract: This report describes the case of a 57-year-old man who underwent a repeated renal biopsy 25 years after the first biopsy in which the diagnosis of IgA nephropathy was made. Although the patient exhibited gradually increasing proteinuria and a slowly progressive renal impairment, the histological findings of the repeat biopsy revealed no evidence of either glomerular inflammatory changes or IgA deposition. Instead, a marked decrease in the glomerular density and hypertrophy of the remnant glomeruli were noted. Almost a complete disappearance of urinary protein excretion by a calorie-restricted diet indicated that the patient's obesity and its related factors may have contributed to the present nephropathic development.
authors.affiliation: Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo. nobuotsuboi@aol.com
authors.forename: Nobuo
authors.initials: N
authors.lastname: Tsuboi
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kawamura
authors.forename: Takeo
authors.initials: T
authors.lastname: Ishii
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Hosoya
mesh_terms: D004038:Diet, Reducing; D005922:Glomerulonephritis, IGA / Q000150:complications*; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000178:diet therapy; D013997:Time Factors