The first synthesis of a novel 5:7:5-fused diimidazodiazepine ring system and some of its chemical properties.
The first synthesis of a novel 5:7:5-fused heterocyclic ring system, a diimidazodiazepine, is reported. The propensity of the ring system to undergo facile, acid-catalyzed nucleophilic addition reactions by neutral carbon and nitrogen nucleophiles has been explored. The ring system has potential future applications in mechanistic studies of formation and repair of DNA interstrand cross-links.
Kumar
Raj
R
Laboratory For Drug Design and Synthesis, Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, Maryland 21250, USA.
Ujjinamatada
Ravi K
RK
Hosmane
Ramachandra S
RS
D001381:Azepines / Q000138:chemical synthesis* / Q000737:chemistry; D007093:Imidazoles / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
D001381:Azepines; D007093:Imidazoles; C029899:imidazole