title: Utility and limitations of a multicenter nocturnal home hemodialysis cohort.
abstract: Nocturnal home hemodialysis (NHD) is the most intensive dialysis strategy among dialytic renal replacement options and is receiving increased attention as more research reveals its physiologic restorative potential compared with conventional hemodialysis; however, a significant gap in knowledge remains concerning the predictors of program success and the clinical outcomes of NHD. This review aims to highlight the methodologic strengths and pitfalls of various study designs as they pertain to NHD research and lays the foundation for the CANandian Slow Long nightly ExtEnded dialysis Programs (CAN-SLEEP), a multicenter NHD research network aimed to facilitate investigation of NHD.
authors.affiliation: Department of Medicine, Division of Nephrology, University of Alberta, Edmonton, Alberta, Canada. robert.pauly@ualberta.ca
authors.forename: Robert P
authors.initials: RP
authors.lastname: Pauly
authors.forename: Michael
authors.initials: M
authors.lastname: Copland
authors.forename: Paul
authors.initials: P
authors.lastname: Komenda
authors.forename: Adeera
authors.initials: A
authors.lastname: Levin
authors.forename: Andreas
authors.initials: A
authors.lastname: Pierratos
authors.forename: Christopher T
authors.initials: CT
authors.lastname: Chan
mesh_terms: D002940:Circadian Rhythm; D015331:Cohort Studies; D006437:Hemodialysis, Home; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D015337:Multicenter Studies as Topic; D012042:Registries; D015203:Reproducibility of Results; D012107:Research Design; D016896:Treatment Outcome