title: Gene expression profiling of liver metastases from colorectal cancer as potential basis for treatment choice.
abstract: At present no reports on gene expression profiling of liver metastases from colorectal cancer are available. We identified two different signatures using Affymetrix platform: epidermal growth factor receptor pathway was upregulated in metachronous lesions, whereas the pathway mainly related to angiogenesis was in synchronous lesions. Synchronous or metachronous liver metastases could be treated differently on the basis of different molecular pathways.
authors.affiliation: Institute of Hematology and Medical Oncology LA Seragnoli, S Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
authors.forename: M A
authors.initials: MA
authors.lastname: Pantaleo
authors.forename: A
authors.initials: A
authors.lastname: Astolfi
authors.forename: M
authors.initials: M
authors.lastname: Nannini
authors.forename: P
authors.initials: P
authors.lastname: Paterini
authors.forename: G
authors.initials: G
authors.lastname: Piazzi
authors.forename: G
authors.initials: G
authors.lastname: Ercolani
authors.forename: G
authors.initials: G
authors.lastname: Brandi
authors.forename: G
authors.initials: G
authors.lastname: Martinelli
authors.forename: A
authors.initials: A
authors.lastname: Pession
authors.forename: A D
authors.initials: AD
authors.lastname: Pinna
authors.forename: G
authors.initials: G
authors.lastname: Biasco
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D066246:ErbB Receptors / Q000235:genetics; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000235:genetics; D016609:Neoplasms, Second Primary / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D066246:ErbB Receptors