Tissue engineering for bone defect healing: an update on a multi-component approach.
The need for an interdisciplinary approach in order to establish new therapeutic strategies for the therapy of bone defects has been acknowledged by the scientific community for many years. This awareness makes itself felt when looking at the multitude of approaches--ranging from cell-based to scaffold-based strategies and also including the use of osteogenic growth factors and genetic engineering--that are currently being combined to assess their potential to develop effective concepts for the treatment of extensive loss of osseous tissue. With a strong focus on the preclinical research in this field, the goal of this review is to give an update on the multi-component approaches that are currently being investigated in tissue engineering of bone.
Drosse
Inga
I
Department of Surgery, University of Munich, LMU, Munich, Germany.
Volkmer
Elias
E
Capanna
Rodolfo
R
De Biase
Pietro
P
Mutschler
Wolf
W
Schieker
Matthias
M
D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use; D001861:Bone Regeneration / Q000502:physiology*; D017102:Fracture Healing; D015316:Genetic Therapy / Q000379:methods; D006133:Growth Substances / Q000627:therapeutic use; D048091:Guided Tissue Regeneration / Q000379:methods; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D023822:Tissue Engineering / Q000379:methods*
D019485:Bone Morphogenetic Proteins; D006133:Growth Substances