Estonian and Russian Federation amoxicillin formulations: a comparative study of in vitro dissolution.
The in vitro dissolution properties were compared for four different formulations from the Estonian drug market and four from the Russian Federation drug market. Seven of the eight formulations tested released at least 75% or 80% amoxicillin during 30- or 90-min dissolution tests (37 degrees C, purified water, 75 rpm), respectively. One marketed Russian Federation formulation released 74% amoxicillin over a 90-min period. The present study shows that, in general, the in vitro dissolution properties of the Russian Federation amoxicillin formulations are, with some minor exceptions, comparable to those of the Estonian formulations.
Bronnikova
O
O
Institute of Pharmacy, University of Tartu, Estonia.
Matto
V
V
Meos
A
A
D000658:Amoxicillin / Q000737:chemistry* / Q000592:standards*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000592:standards*; D002626:Chemistry, Pharmaceutical; D004957:Estonia; D007700:Kinetics; D012015:Reference Standards; D012426:Russia; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet
D000900:Anti-Bacterial Agents; D000658:Amoxicillin