[Tumour stem cells in glioma--tomorrow's therapeutic target?].
Despite intensive research, gliomas still lead to death in most cases. The isolation of brain tumour stem cells from gliomas has paved the way for a growing body of evidence suggesting that these cells are responsible for the resistance of gliomas towards conventional therapy. Recent results suggest that the growth of brain tumours can be inhibited by treatment strategies targeting the brain tumour stem cells. Here, the brain tumour stem cell paradigm is described with a focus on tumour stem cell characteristics and the role of this subpopulation of tumour cells in the resistance towards radiation and chemotherapy.
Christensen
Karina
K
Odense Universitetshospital, Afdeling for Klinisk Patologi, Odense C. karina.christensen@ouh.regionsyddanmark.dk
Schrøder
Henrik Daa
HD
Kristensen
Bjarne Winther
BW
D015703:Antigens, CD; D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000528:radiation effects; D005910:Glioma / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D006801:Humans; D007150:Immunohistochemistry; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects
D015703:Antigens, CD