title: Determination of wall tension in cerebral artery aneurysms by numerical simulation.
abstract: OBJECTIVE
  Cerebral artery aneurysms rupture when wall tension exceeds the strength of the wall tissue. At present, risk-assessment of unruptured aneurysms does not include evaluation of the lesions shape, yet clinical experience suggests that this is of importance. We aimed to develop a computational model for simulation of fluid-structure interaction in cerebral aneurysms based on patient specific lesion geometry, with special emphasis on wall tension.
  
  
  METHODS
  An advanced isogeometric fluid-structure analysis model incorporating flexible aneurysm wall based on patient specific computed tomography angiogram images was developed. Variables used in the simulation model were retrieved from a literature review.
  
  
  RESULTS
  The simulation results exposed areas of high wall tension and wall displacement located where aneurysms usually rupture.
  
  
  CONCLUSIONS
  We suggest that analyzing wall tension and wall displacement in cerebral aneurysms by numeric simulation could be developed into a novel method for individualized prediction of rupture risk.
authors.affiliation: Department of Neurosurgery, University hospital of North Norway, Tromsø, Norway.
authors.forename: Jørgen Gjernes
authors.initials: JG
authors.lastname: Isaksen
authors.forename: Yuri
authors.initials: Y
authors.lastname: Bazilevs
authors.forename: Trond
authors.initials: T
authors.lastname: Kvamsdal
authors.forename: Yongjie
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jon H
authors.initials: JH
authors.lastname: Kaspersen
authors.forename: Knut
authors.initials: K
authors.lastname: Waterloo
authors.forename: Bertil
authors.initials: B
authors.lastname: Romner
authors.forename: Tor
authors.initials: T
authors.lastname: Ingebrigtsen
mesh_terms: D000368:Aged; D002536:Cerebral Arteries / Q000503:physiopathology* / Q000648:ultrastructure; D003198:Computer Simulation; D005260:Female; D018056:Hemorheology; D006801:Humans; D002532:Intracranial Aneurysm / Q000503:physiopathology*; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000648:ultrastructure; D008955:Models, Cardiovascular; D011859:Radiography; D012306:Risk; D012422:Rupture, Spontaneous; D033081:Shear Strength; D013718:Tensile Strength