Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate.
Ciulli
Alessio
A
University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB21EW, UK. ac313@cam.ac.uk
Scott
Duncan E
DE
Ando
Michiyo
M
Reyes
Fernando
F
Saldanha
S Adrian
SA
Tuck
Kellie L
KL
Chirgadze
Dimitri Y
DY
Blundell
Tom L
TL
Abell
Chris
C
D000255:Adenosine Triphosphate / Q000378:metabolism; D055162:Biocatalysis; D003067:Coenzymes / Q000378:metabolism; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D009169:Mycobacterium tuberculosis / Q000201:enzymology*; D010453:Peptide Synthases / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D013449:Sulfonamides / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology
D003067:Coenzymes; D004791:Enzyme Inhibitors; D013449:Sulfonamides; D000255:Adenosine Triphosphate; D010453:Peptide Synthases; C022318:pantothenate synthetase