title: Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues.
abstract: Our knowledge on tissue- and disease-specific functions of human genes is rather limited and highly context-specific. Here, we have developed a method for the comparison of mRNA expression levels of most human genes across 9,783 Affymetrix gene expression array experiments representing 43 normal human tissue types, 68 cancer types, and 64 other diseases. This database of gene expression patterns in normal human tissues and pathological conditions covers 113 million datapoints and is available from the GeneSapiens website.
authors.affiliation: Medical Biotechnology, VTT Technical Research Centre and University of Turku, Itäinen pitkäkatu 4C, Turku, Finland. sami.k.kilpinen@helsinki.fi
authors.forename: Sami
authors.initials: S
authors.lastname: Kilpinen
authors.forename: Reija
authors.initials: R
authors.lastname: Autio
authors.forename: Kalle
authors.initials: K
authors.lastname: Ojala
authors.forename: Kristiina
authors.initials: K
authors.lastname: Iljin
authors.forename: Elmar
authors.initials: E
authors.lastname: Bucher
authors.forename: Henri
authors.initials: H
authors.lastname: Sara
authors.forename: Tommi
authors.initials: T
authors.lastname: Pisto
authors.forename: Matti
authors.initials: M
authors.lastname: Saarela
authors.forename: Rolf I
authors.initials: RI
authors.lastname: Skotheim
authors.forename: Mari
authors.initials: M
authors.lastname: Björkman
authors.forename: John-Patrick
authors.initials: JP
authors.lastname: Mpindi
authors.forename: Saija
authors.initials: S
authors.lastname: Haapa-Paananen
authors.forename: Paula
authors.initials: P
authors.lastname: Vainio
authors.forename: Henrik
authors.initials: H
authors.lastname: Edgren
authors.forename: Maija
authors.initials: M
authors.lastname: Wolf
authors.forename: Jaakko
authors.initials: J
authors.lastname: Astola
authors.forename: Matthias
authors.initials: M
authors.lastname: Nees
authors.forename: Sampsa
authors.initials: S
authors.lastname: Hautaniemi
authors.forename: Olli
authors.initials: O
authors.lastname: Kallioniemi
mesh_terms: D030541:Databases, Genetic; D004194:Disease / Q000235:genetics; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D009928:Organ Specificity