High-molecular-weight adiponectin and leptin levels in cord blood are associated with anthropometric measurements at birth.
OBJECTIVE
High-molecular-weight adiponectin (HMW-ad) is an active form of adiponectin. No information is available with respect to HMW-ad in neonates. The aims of this study were to examine whether HMW-ad is present in cord blood, to define the association between the concentrations of cord blood HMW-ad and leptin, and their correlation with anthropometric measurements of term neonates at birth.


METHODS
Venous cord blood samples were obtained from 135 term healthy neonates (birth weight 2,261-4,164 g) born at Showa University Hospital. Total adiponectin (T-ad), HMW-ad and leptin levels were measured by ELISA.


RESULTS
HMW-ad levels were 14.9 +/- 5.8 microg/ml and the ratio of HMW-ad to T-ad was 0.49 +/- 0.15. In a multiple regression analysis, cord blood HMW-ad levels were a significant predictor of birth weight and birth length, and leptin level was a significant predictor of birth weight and birth weight to body length ratio. There was a significant relationship between concentrations of HMW-ad and leptin controlling for sex, gestational age and birth weight.


CONCLUSIONS
These results show that HMW-ad exists as a half of T-ad in the cord blood. Leptin and HMW-ad may regulate synergistically fetal growth.
Inoue
Makoto
M
Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan.
Itabashi
Kazuo
K
Nakano
Yuya
Y
Nakano
Yasuko
Y
Tobe
Takashi
T
D052242:Adiponectin / Q000097:blood*; D001724:Birth Weight; D001827:Body Height; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D047109:Fetal Development / Q000502:physiology; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D020738:Leptin / Q000097:blood*; D008297:Male; D008970:Molecular Weight; D011247:Pregnancy
D052242:Adiponectin; D020738:Leptin