title: Cytomics and nanobioengineering.
abstract: The finding that an individual's genome differs as much as by many million variants from that of the human reference assembly diminished the great enthusiasm that every disease could be predicted based on nucleotide polymorphisms. Even individual cells of an organ may be specifically equipped to perform specific tasks and that the information of individual cells in a cell system is key information to understand function or dysfunction. Therefore, cytomics received great attention during the last years as it allows to quantitatively and qualitatively analyzing great number of individual cells, cell constituents, and of their intracellular and functional interactions in a cellular system and also giving the concept of analysis of these data.Exhaustive data extraction from multiparametric assays and multiple tests are the prerequisite for prediction of drug toxicity. Cytomics, as novel approach for unsupervised data analysis give a chance to find the most predictive parameters, which describe best the toxicity of a chemical. Cytomics is intrinsically connected to drug development and drug discovery.Focused on small structures, nanobioengineering is the ideal partner of cytomics, the systems biological discipline for cell population analysis. Realizing the idea "from the molecule to the patient" develops and offers chemical compounds, proteins, and other biomolecules, cells as well as tissues as instruments and products for a wide variety of biotechnological and biomedical applications.The integrative nanobioengineering combining different disciplines of nanotechnology will promote the development of innovative therapies and diagnostic methods. It can improve the precision of the measurements with focus on single cell analysis. By nanobioengineering and whole body imaging techniques, cytomics covers the field from molecules through bacterial cells, eukaryotic tissues, and organs to small animal live analysis. Toxicological testing and medical drug development are currently strongly broadening. It harbors the promise to substantially impact on various fields of biomedicine, drug discovery, and predictive medicine.As the number of scientific data is rising exponentially, new data analysis tools and strategies like cytomics and nanobioengineering take a lead and get closer to application. Bionanoengineering may strongly support the quantitative data supply, thus strengthening the rational for cytomics approach.
authors.affiliation: Department of Pediatric Cardiology, Heart Center Leipzig, University of Leipzig, Leipzig, Germany.
authors.forename: Arkadiusz
authors.initials: A
authors.lastname: Pierzchalski
authors.forename: Andrea
authors.initials: A
authors.lastname: Robitzki
authors.forename: Anja
authors.initials: A
authors.lastname: Mittag
authors.forename: Frank
authors.initials: F
authors.lastname: Emmrich
authors.forename: Ulrich
authors.initials: U
authors.lastname: Sack
authors.forename: José-Enrique
authors.initials: JE
authors.lastname: O'Connor
authors.forename: József
authors.initials: J
authors.lastname: Bocsi
authors.forename: Attila
authors.initials: A
authors.lastname: Tárnok
mesh_terms: D001709:Biotechnology; D003585:Cell Biology; D016923:Cell Death; D002454:Cell Differentiation; D003592:Cytophotometry / Q000379:methods; D006801:Humans; D046228:Microarray Analysis; D036103:Nanotechnology; D012038:Regeneration