title: Protection of the gastrointestinal tract epithelium against damage from low pH beverages.
abstract: Extensive consumption of low pH beverages such as citrus juices (pHs 2.3 to 4.3), alcoholic beverages (pHs 2.7 to 4.5), and soft drinks (pHs 2.3 to 4.2) has raised the question of whether exposure of the gastrointestinal (GI) tract to acidic beverages will cause damage to the epithelial lining. To evaluate the potential effects of low pH beverages on the GI tract epithelium, a detailed examination of the literature was undertaken. In some animal models, there is evidence of damage to GI epithelial cells following exposure to low pH beverages; however, in these studies there is no definitive relationship between acidity and the amount or severity of damage. Results from several other studies, conducted in both animals and humans, indicate a lack of adverse effects on epithelial cells. Furthermore, there is no evidence that damage is irreversible. Permanent damage from routine exposure to acidic beverages in humans would not be expected because of repair mechanisms that are available to maintain a healthy epithelium. Additionally, numerous physical, chemical, and biological mechanisms are in place to prevent damage to the epithelial cells. Finally, the safe history of consumption of low pH beverages, including various fruit juices, supports the conclusion that low pH beverage ingestion does not cause damage to the GI epithelium.
authors.affiliation: Massachusetts General Hospital, Pediatric Gastroenterology & Nutrition, Boston, MA 02114, USA. rkleinman@partners.org
authors.forename: R E
authors.initials: RE
authors.lastname: Kleinman
mesh_terms: D000143:Acids / Q000009:adverse effects; D001628:Beverages / Q000009:adverse effects*; D004847:Epithelial Cells / Q000187:drug effects* / Q000502:physiology; D005767:Gastrointestinal Diseases / Q000517:prevention & control*; D041981:Gastrointestinal Tract / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D006863:Hydrogen-Ion Concentration
chemical_list: D000143:Acids