Synthesis of a novel linear polymer of a macrocyclic polyamine copper (II) complex and its interaction with plasmid DNA.
The novel linear polymer of a macrocyclic polyamine copper (II) complex, which has many cyclen groups linked by epichlorohydrin, has been synthesized as a DNA cleavage agent. The structure of the polymer 3 was identified by 1HNMR and IR and its molecular weight was measured by GPC. The result of agarose gel electrophoresis assay showed that Cu-(II) complex 4 could act as a powerful catalyst for the cleavage of plasmid DNA under physiological conditions.
Xiang
Yong-Zhe
YZ
Department of Chemistry, Key Laboratory of Green Chemistry and Technology (Ministry of Education), Sichuan University, Chengdu, Sichuan, China.
Zhou
Li-Hong
LH
Jiang
Ning
N
Lin
Hong-Hui
HH
Yu
Xiao-Qi
XQ
D003300:Copper / Q000737:chemistry* / Q000378:metabolism; D000080027:Cyclams; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D053837:DNA Cleavage; D004811:Epichlorohydrin / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000737:chemistry; D008958:Models, Molecular; D010957:Plasmids / Q000737:chemistry / Q000378:metabolism*; D011073:Polyamines / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis*
D000080027:Cyclams; D006571:Heterocyclic Compounds; D011073:Polyamines; D011108:Polymers; D004811:Epichlorohydrin; D003300:Copper; D004247:DNA; C038072:cyclen