title: [Histamine releasing and immunomodulating activity of dental restorative materials].
abstract: Histamine releasing and immunomodulating activity of the following dental restorative materials (DRM) - Prizmafil, Filtek Z250, XRV Herculite Prodigy, Glasiosite, Te-Econol, Valux Plus, Polofil Supra were studied. It was shown that DRM under study as a rule did not possess the ability to release histamine (H) from human blood basophile (BB) excluding Filtek Z250 which release H from BB in patients with allergy and sound donors. The studied DRM implanted under mouse skin were able to modulate immune response to the allergen, at that some of them increased antibodies of IgE-class forming and other suppressed immune response caused by IgG-antibody forming. Received data have certain significance in the scheme of safety evaluation and individual assessment of DRM having acceptable biocompatibility for specific patient.
authors.forename: A A
authors.initials: AA
authors.lastname: Babakhin
authors.forename: A I
authors.initials: AI
authors.lastname: Volozhin
authors.forename: A A
authors.initials: AA
authors.lastname: Zhuravleva
authors.forename: L N
authors.initials: LN
authors.lastname: Kazarina
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Babakhina
authors.forename: L V
authors.initials: LV
authors.lastname: Dubova
authors.forename: L M
authors.initials: LM
authors.lastname: DuBuske
mesh_terms: D000180:Acrylic Resins / Q000494:pharmacology*; D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects*; D003188:Composite Resins / Q000494:pharmacology*; D006632:Histamine / Q000096:biosynthesis / Q000378:metabolism*; D006801:Humans; D007136:Immunoglobulins / Q000187:drug effects*; D016876:Metal Ceramic Alloys / Q000494:pharmacology*; D051379:Mice; D011140:Polyurethanes / Q000494:pharmacology*; D051381:Rats
chemical_list: D000180:Acrylic Resins; C029012:Composite Dental Resin; D003188:Composite Resins; D007136:Immunoglobulins; D016876:Metal Ceramic Alloys; D011140:Polyurethanes; D006632:Histamine