Extensive ganglioneuromatosis of gallbladder.
A case of extensive ganglioneuromatosis (GN) of gallbladder is presented. A 38-year-old man presented with a hepatic hilar mass (Ø ~ 48 mm) and gall stones. He had undergone total thyroidectomy for medullary thyroid carcinoma 8 years earlier. The hepatic hilus tumor, which had been clinically suspected to be a lymph node metastasis from the medullary thyroid carcinoma, was found to be pheochromocytoma. The gallbladder, resected with a clinical diagnosis of cholelithiasis, showed extensive transmural GN despite a grossly normal appearance. Taking into account the past history, the patient was diagnosed as having multiple endocrine neoplasia 2b (MEN2b)-associated GN of gallbladder and ectopic pheochromocytoma. As GN of gallbladder in MEN2b has been rarely reported, the histological findings are described in detail and a brief review of literature is carried out.
Sakuma
Takahiko
T
Department of Clinical Pathology, Osaka Rosai Hospital, Sakai, Kita, Osaka, Japan. thsakuma@atsumi.jaaikosei.or.jp
Hirota
Masaki
M
Ohashi
Hiroshi
H
Kakudo
Kennichi
K
Kawano
Kiyoshi
K
D000310:Adrenal Gland Neoplasms / Q000473:pathology / Q000601:surgery; D000311:Adrenal Glands; D000328:Adult; D002769:Cholelithiasis / Q000175:diagnosis; D002828:Choristoma / Q000473:pathology; D003937:Diagnosis, Differential; D005705:Gallbladder Diseases / Q000473:pathology; D005706:Gallbladder Neoplasms / Q000473:pathology* / Q000601:surgery; D005729:Ganglioneuroma / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D018814:Multiple Endocrine Neoplasia Type 2b / Q000473:pathology; D010673:Pheochromocytoma / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed