Mucosal immunity in Toxoplasma gondii infection.
Toxoplasma gondii is an intracellular parasite that frequently infects a large spectrum of warm-blooded animals. This parasite induces abortion and establishes both chronic and silent infections, particularly in the brain. Parasite penetration into the host activates a strong anti-parasite immune response. In the present paper, we will discuss the interplay between innate and adaptive immunity that occurs within the infected intestine to clear the parasite and to maintain intestinal homeostasis despite the exacerbation of an inflammatory immune response.
Schulthess
J
J
RPPI, Institut Pasteur-INRA, 28, rue du Dr Roux, 75724 Paris cedex 15, France.
Fourreau
D
D
Darche
S
S
Meresse
B
B
Kasper
L
L
Cerf-Bensussan
N
N
Buzoni-Gatel
D
D
D000818:Animals; D016207:Cytokines / Q000276:immunology; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D018928:Immunity, Mucosal; D007413:Intestinal Mucosa / Q000276:immunology / Q000469:parasitology; D014122:Toxoplasma / Q000276:immunology* / Q000502:physiology*; D014123:Toxoplasmosis / Q000276:immunology*
D016207:Cytokines