title: Bioassay-guided isolation of antiplasmodial anacardic acids derivatives from the whole plants of Viola websteri Hemsl.
abstract: The petroleum ether extract of Viola websteri Hemsl. (Violaceae) was investigated for its activity against chloroquine-sensitive strains of Plasmodium falciparum using the parasite lactate dehydrogenase assay method. The main antiplasmodial principles, 6-(8'Z-pentadecenyl)-salicylic acid (1) and 6-(8'Z, 11'Z, 14'Z-heptadecatrienyl)-salicylic acid (2), have been isolated from V. websteri for the first time. This is the first report on the antiplasmodial activity of the compounds from V. websteri.
authors.affiliation: Department of Integrative Medicine, College of Medicine, Korea University, Anam-dong 5ga, Seongbuk-gu, Seoul 136-705, South Korea.
authors.forename: Sung Jae
authors.initials: SJ
authors.lastname: Lee
authors.forename: Won-Hwan
authors.initials: WH
authors.lastname: Park
authors.forename: Hyung-In
authors.initials: HI
authors.lastname: Moon
mesh_terms: D048729:Anacardic Acids / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D015394:Molecular Structure; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects*; D015800:Protozoan Proteins / Q000378:metabolism; D032413:Viola / Q000737:chemistry*
chemical_list: D048729:Anacardic Acids; D000962:Antimalarials; D010936:Plant Extracts; D015800:Protozoan Proteins; D007770:L-Lactate Dehydrogenase