title: Mapping of quantitative trait loci for cholesterol, LDL, HDL, and triglyceride serum concentrations in pigs.
abstract: The fine mapping of polymorphisms influencing cholesterol (CT), triglyceride (TG), and lipoprotein serum levels in human and mouse has provided a wealth of knowledge about the complex genetic architecture of these traits. The extension of these genetic analyses to pigs would be of utmost importance since they constitute a valuable biological and clinical model for the study of coronary artery disease and myocardial infarction. In the present work, we performed a whole genome scan for serum lipid traits in a half-sib Duroc pig population of 350 individuals. Phenotypic registers included total CT, TG, and low (LDL)- and high (HDL)-density lipoprotein serum concentrations at 45 and 190 days of age. This approach allowed us to identify two genomewide significant quantitative trait loci (QTL) for HDL-to-LDL ratio at 45 days (SSC6, 84 cM) and for TG at 190 days (SSC4, 23 cM) as well as a number of chromosomewide significant QTL. The comparison of QTL locations at 45 and 190 days revealed a notable lack of concordance at these two time points, suggesting that the effects of these QTL are age specific. Moreover, we have observed a considerable level of correspondence among the locations of the most significant porcine lipid QTL and those identified in humans. This finding might suggest that, in mammals, diverse polymorphisms located in a common set of genes are involved in the genetic variation of serum lipid levels.
authors.affiliation: Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona, Bellaterra, Spain. raquel.quintanilla@irta.cat
authors.forename: David
authors.initials: D
authors.lastname: Gallardo
authors.forename: Ramona N
authors.initials: RN
authors.lastname: Pena
authors.forename: Marcel
authors.initials: M
authors.lastname: Amills
authors.forename: Luis
authors.initials: L
authors.lastname: Varona
authors.forename: Oscar
authors.initials: O
authors.lastname: Ramírez
authors.forename: Josep
authors.initials: J
authors.lastname: Reixach
authors.forename: Isabel
authors.initials: I
authors.lastname: Díaz
authors.forename: Joan
authors.initials: J
authors.lastname: Tibau
authors.forename: Joaquim
authors.initials: J
authors.lastname: Soler
authors.forename: Josep M
authors.initials: JM
authors.lastname: Prat-Cuffi
authors.forename: José L
authors.initials: JL
authors.lastname: Noguera
authors.forename: Raquel
authors.initials: R
authors.lastname: Quintanilla
mesh_terms: D000818:Animals; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D002874:Chromosome Mapping; D005260:Female; D015894:Genome, Human; D055106:Genome-Wide Association Study / Q000379:methods; D023281:Genomics / Q000379:methods; D005838:Genotype; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D010641:Phenotype; D040641:Quantitative Trait Loci / Q000235:genetics*; D013045:Species Specificity; D013552:Swine; D013997:Time Factors; D014280:Triglycerides / Q000097:blood*
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides