title: The perception threshold measurement can be a useful tool for evaluation of sensitive skin.
abstract: Sensitive skin is characterized by subjective symptoms that are hard to quantify. However, a neurobiological approach could improve our understanding of the nature of skin sensitivity. In this study, we measured the sensory perception of well-controlled electric currents on the skin that stimulated sensory nerve fibres such as the myelinated A fibre, A delta fibre and unmyelinated c-fibre. The sensory perception thresholds were obtained quantitatively from subjects with sensitive-prone skin and controls. Application of 0.075% capsaicin, known to stimulate the nociceptor c-fibre, was topically applied; then the sensory perception thresholds were measured to determine whether the exposure to nociceptive stimulation could affect the subsequent sensory perception. The results showed that the perception thresholds of skin sensitive-prone subjects were low for the c-fibre measurements at 5 Hz electric current stimulation. Furthermore, a wide variation in sensory perception was noted in the skin sensitive-prone subjects after topical application of capsaicin. In conclusion, the abnormal sensory perception in individuals with sensitive skin appears to be related to neurological instability, where c-fibre nociception plays a role. Thus, quantitative sensory perception threshold measurement was found to be a useful method for the identification of skin sensitive-prone subjects.
authors.affiliation: Department of Dermatology, Chonnam University Medical School, Hack-Dong 8, Gwangju 501-757, Korea. seongkim@chonnam.ac.kr
authors.forename: S-J
authors.initials: SJ
authors.lastname: Kim
authors.forename: S-U
authors.initials: SU
authors.lastname: Lim
authors.forename: Y-H
authors.initials: YH
authors.lastname: Won
authors.forename: S-S
authors.initials: SS
authors.lastname: An
authors.forename: E-Y
authors.initials: EY
authors.lastname: Lee
authors.forename: S-J
authors.initials: SJ
authors.lastname: Moon
authors.forename: J
authors.initials: J
authors.lastname: Kim
mesh_terms: D002211:Capsaicin / Q000494:pharmacology; D004558:Electric Stimulation; D006801:Humans; D012684:Sensory Thresholds; D012867:Skin / Q000187:drug effects; D012879:Skin Physiological Phenomena
chemical_list: D002211:Capsaicin