Treatment of peritoneal mesothelioma in pediatric patients.
Peritoneal mesothelioma is a rare and often aggressive malignancy, mostly affecting asbestos exposed adults. We present four pediatric peritoneal cases treated with a cisplatin-based doublet regimen, the standard of care in the systemic therapy of adult mesothelioma. Treatment was well tolerated, and three of these patients have achieved long-term survival. The fathers of three of the patients worked in the construction industry and may have been the source of indirect asbestos exposure.
Cioffredi
Leigh-Anne
LA
Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.
Jänne
Pasi A
PA
Jackman
David M
DM
D000293:Adolescent; D001194:Asbestos; D002945:Cisplatin / Q000627:therapeutic use; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000188:drug therapy*; D010534:Peritoneal Neoplasms / Q000188:drug therapy*; D016896:Treatment Outcome; D055815:Young Adult
D001194:Asbestos; D002945:Cisplatin