Manipulating replication processes within a dynamic covalent framework.
The reaction of an amine bearing an amidopyridine recognition site and an aldehyde bearing a carboxylic acid recognition site affords an imine that is capable of directing its own formation through a dynamic covalent replication cycle. Additionally, the amine, formed by reduction of the replicating imine, is a more efficient catalyst for the formation of the replicating imine than the imine is a catalyst for its own formation.
del Amo
Vicente
V
EaStCHEM and Centre for Biomolecular Sciences, School of Chemistry, University of St. Andrews, North Haugh, St. Andrews, Fife KY16 9ST, United Kingdom.
Slawin
Alexandra M Z
AM
Philp
Douglas
D
D008956:Models, Chemical; D008958:Models, Molecular; D015394:Molecular Structure; D014961:X-Ray Diffraction