Model-based identification and diagnosis of a porcine model of induced endotoxic shock with hemofiltration.
A previously validated cardiovascular system (CVS) model and parameter identification method for cardiac and circulatory disease states are extended and further validated in a porcine model (N=6) of induced endotoxic shock with hemofiltration. Errors for the identified model are within 10% when the model is re-simulated and compared to the clinical data. All identified parameter trends over time in the experiments match clinically expected changes both individually and over the cohort. This work represents a further clinical validation of these model-based cardiovascular diagnosis and therapy guidance methods for use with monitoring endotoxic disease states.
Starfinger
C
C
Centre for Bioengineering, University of Canterbury, Private Bag 4800, Christchurch, New Zealand. cst45@student.canterbury.ac.nz
Chase
J G
JG
Hann
C E
CE
Shaw
G M
GM
Lambermont
B
B
Ghuysen
A
A
Kolh
P
P
Dauby
P C
PC
Desaive
T
T
D000818:Animals; D003198:Computer Simulation; D004195:Disease Models, Animal; D006439:Hemodynamics; D006440:Hemofiltration; D008955:Models, Cardiovascular; D012772:Shock, Septic / Q000175:diagnosis* / Q000503:physiopathology; D013552:Swine