A novel method for the synthesis of substituted 3,4-dihydrocoumarin derivatives via isocyanide-based three-component reaction.
A new one-pot procedure for the efficient synthesis of novel 3,4-dihydrocoumarin derivatives using commercially available substituted 2-hydroxybenzaldehydes, Meldrum's acid, and isocyanides by a three-component condensation reaction in dichloromethane at room temperature without using any catalysts and activation was developed.
Shaabani
Ahmad
A
Department of Chemistry, Shahid Beheshti University, P. O. Box 19396-4716, Tehran, Iran. a-shaabani@cc.sbu.ac.ir
Sarvary
Afshin
A
Soleimani
Ebrahim
E
Rezayan
Ali Hossein
AH
Heidary
Marjan
M
D001547:Benzaldehydes / Q000737:chemistry; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry; D003486:Cyanides; D004146:Dioxanes; D009682:Magnetic Resonance Spectroscopy; D008722:Methods; D015394:Molecular Structure; D013055:Spectrophotometry, Infrared
D001547:Benzaldehydes; D003374:Coumarins; D003486:Cyanides; D004146:Dioxanes; C076489:Meldrum's acid