Electrochemical biosensor featuring a two-enzyme pathway and DNA for screening toxic reactive metabolites of arylamines.
We demonstrate for the first time a biosensor featuring a sequential two-enzyme pathway suitable to screen potentially toxic reactive metabolites generated during metabolism.
So
Minjeong
M
Department of Chemistry, University of Connecticut, USA.
Schenkman
John B
JB
Rusling
James F
JF
D000105:Acetyl Coenzyme A / Q000737:chemistry*; D000123:Acetyltransferases / Q000737:chemistry*; D015374:Biosensing Techniques; D002384:Catalysis; D019388:Cytochrome P-450 CYP1A2 / Q000737:chemistry*; D004247:DNA / Q000737:chemistry* / Q000187:drug effects; D004563:Electrochemistry; D007093:Imidazoles / Q000032:analysis* / Q000378:metabolism / Q000633:toxicity; D008567:Membranes, Artificial; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013997:Time Factors
D007093:Imidazoles; D008567:Membranes, Artificial; D000105:Acetyl Coenzyme A; D004247:DNA; C049584:2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; D019388:Cytochrome P-450 CYP1A2; D000123:Acetyltransferases