title: Water-soluble zinc porphyrins as artificial receptors for amino acids.
abstract: The binding of amino acids to water-soluble zinc porphyrins in basic aqueous solution was spectrophotometrically analyzed. The amino acids were bound to the porphyrins through the coordination of the N atom with the central zinc ion. Additional attractions arise due to Coulomb interactions between the -COO(-) anion of the amino acids and the -N(CH(3))(3)(+) cation of the porphyrin substituents and due to hydrophobic interactions between the porphyrin plane and the hydrophobic substituents of the amino acids. These attractions could be explained based on the binding data. The compensatory relationships of DeltaS and DeltaH were also discussed.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan. h-imai@hokuriku-u.ac.jp
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Imai
authors.forename: Kensuke
authors.initials: K
authors.lastname: Misawa
authors.forename: Hiroki
authors.initials: H
authors.lastname: Munakata
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Uemori
mesh_terms: D000588:Amines / Q000737:chemistry; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008665:Metalloporphyrins / Q000737:chemistry*; D017459:Receptors, Amino Acid / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D000588:Amines; D008665:Metalloporphyrins; D017459:Receptors, Amino Acid; C017802:zinc hematoporphyrin