[Experiment of effective components from traditional Chinese herbs on ischemic left ventricular remodeling].
OBJECTIVE
To investigate the effects of effective components extracted from medicines compatibility on ischemic myocardial remodeling.


METHODS
The animal models of ischemic myocardial remodeling was copied by ligating the left anterior descending branch of coronary artery in rat. And then decoction and effective components extracted from the same medicines were administrated to rats. The heart function was detected by ultrasound diagnostic apparatus and the heart morphology was examined by Hematoxylin and Eosin, picrosirius staining respectively on the 3rd and 56rd day.


RESULTS
Both concentrated decoction and effective components compatibility showed good restrained effects on ventricle malignant remodeling, such as improved heart function, reduced the area of myocardial infarction, lowered heart index, mitigated the fibrosis level and decreased apoptosis cell numbers in infarction and non-infarction areas. The difference were statistically significant when compared with the control group (P < 0.01, P < 0.05), and effective components treated group had better effects than concentrated decoction group (P < 0.05). Concentrated decoction group showed little effects on the 3rd day, while effective components group showed significant effect (P < 0.05).


CONCLUSIONS
Effective components compatibility has better effects on inhibiting the process of ischemic myocardial remodeling than concentrated decoction. Effective components compatibility has better effects on ventricle malignant remodeling by eliminating the interfrence non-pharmacodynamic elements of the medicine.
Wang
Ji
J
Guang' anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 10053, China.
Guo
Li-Li
LL
Zheng
Jun
J
Pan
Ju-Hua
JH
Wang
Yan-Yun
YY
Chen
Zhao
Z
Li
Duo-Jiao
DJ
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D003094:Collagen / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D006321:Heart / Q000503:physiopathology; D007511:Ischemia / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000473:pathology; D051381:Rats; D020257:Ventricular Remodeling / Q000187:drug effects*
D004365:Drugs, Chinese Herbal; D003094:Collagen