Outcome of high-risk neonates with congenital complete heart block paced in the first 24 hours after birth.
OBJECTIVE
Risk factors for poor outcome with congenital complete heart block include prematurity, low birth weight, hydrops, low ventricular rates, and congenital heart disease. In this group, medical therapy is often ineffective, pacing is technically challenging, and mortality exceeds 80%. The purpose of this study is to assess outcomes of patients with congenital complete heart block who were paced in the first 24 hours after birth owing to the presence of known risk factors.


METHODS
We performed a retrospective review of patients with congenital complete heart block paced in the first 24 hours after birth at our institution between November 1, 1995, and July 31, 2007.


RESULTS
Thirteen patients were identified, 4 of whom had heterotaxy syndrome. Eleven patients had temporary epicardial pacing wires placed; 2 received permanent pacemakers as the initial mode of pacing. There were 7 deaths (54% mortality) at a mean age of 19.9 +/- 19 days. Among 7 patients with structural heart disease, there was 1 survivor. Among 6 patients with structurally normal hearts, there were 5 survivors (P = .025). Patients with temporary wires who survived to permanent pacemaker implantation (6/11) used their temporary leads for 33.8 +/- 18.3 days.


CONCLUSIONS
In the severely affected fetus with congenital complete heart block and significant structural heart disease, outcomes remain poor; however, neonates with congenital complete heart block and structurally normal hearts who are monitored antenatally and delivered in a planned fashion at an institution capable of early pacing can have favorable outcomes. The use of temporary pacing wires is an option in the management of these patients.
Glatz
Andrew C
AC
The Children's Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4399, USA. glatz@email.chop.edu
Gaynor
J William
JW
Rhodes
Larry A
LA
Rychik
Jack
J
Tanel
Ronn E
RE
Vetter
Victoria L
VL
Kaltman
Jonathan R
JR
Nicolson
Susan C
SC
Montenegro
Lisa
L
Shah
Maully J
MJ
D002304:Cardiac Pacing, Artificial / Q000379:methods; D005260:Female; D006327:Heart Block / Q000151:congenital* / Q000401:mortality / Q000628:therapy*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome