title: Evaluation of diagnosis and treatment results in children with Graves' disease with emphasis on the pubertal status of patients.
abstract: This retrospective study evaluated the clinical and laboratory characteristics at presentation and treatment results of patients with Graves' disease (GD) with respect to pubertal status. Records of 143 patients (108 F, 35 M) were reviewed in a multicenter study. At diagnosis, 38% of patients were prepubertal. Anti-thyroid drugs (ATD) were used as initial therapy. There was no significant difference in clinical and laboratory characteristics at diagnosis, during treatment and adverse reaction to ATD with respect to pubertal status. Twenty patients (7 prepubertal, 13 pubertal) reached remission on ATD. Surgery was performed in seven and radioiodine (RAI) in four patients. Duration of treatment needed to achieve remission was longer in prepubertal (4.2 +/- 1.0 yr) than in pubertal patients (3.1 +/- 1.3 yr) (p = 0.02). The rate of remission was not different between prepubertal (25.9%) and pubertal patients (33.3%) (p = 0.59). ATD were associated with low remission rate in pediatric GD and required longer duration of therapy in prepubertal patients. For definitive treatment in older children, RAI could be evaluated as the initial therapy.
authors.affiliation: Istanbul Faculty of Medicine, Istanbul University, Turkey. sukranpoyrazoglu@yahoo.com
authors.forename: Sükran
authors.initials: S
authors.lastname: Poyrazoğlu
authors.forename: Nurcin
authors.initials: N
authors.lastname: Saka
authors.forename: Firdevs
authors.initials: F
authors.lastname: Bas
authors.forename: Pinar
authors.initials: P
authors.lastname: Isguven
authors.forename: Aysegul
authors.initials: A
authors.lastname: Dogu
authors.forename: Serap
authors.initials: S
authors.lastname: Turan
authors.forename: A
authors.initials: A
authors.lastname: Bereket
authors.forename: Abdullah
authors.initials: A
authors.lastname: Turan
authors.forename: Sevil
authors.initials: S
authors.lastname: Sarikaya
authors.forename: Erdal
authors.initials: E
authors.lastname: Adal
authors.forename: Filiz
authors.initials: F
authors.lastname: Cizmecioglu
authors.forename: Filiz
authors.initials: F
authors.lastname: Cizmeci
authors.forename: Halil
authors.initials: H
authors.lastname: Saglam
authors.forename: Oya
authors.initials: O
authors.lastname: Ercan
authors.forename: Nihal
authors.initials: N
authors.lastname: Memioglu
authors.forename: Hulya
authors.initials: H
authors.lastname: Günöz
authors.forename: Ruveyde
authors.initials: R
authors.lastname: Bundak
authors.forename: Feyza
authors.initials: F
authors.lastname: Darendeliler
authors.forename: Metin
authors.initials: M
authors.lastname: Yildiz
authors.forename: Tulay
authors.initials: T
authors.lastname: Guran
authors.forename: Teoman
authors.initials: T
authors.lastname: Akcay
authors.forename: Leyla
authors.initials: L
authors.lastname: Akin
authors.forename: Sukru
authors.initials: S
authors.lastname: Hatun
mesh_terms: D000293:Adolescent; D000465:Algorithms; D013956:Antithyroid Agents / Q000627:therapeutic use; D001837:Body Weights and Measures; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006111:Graves Disease / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D007223:Infant; D008297:Male; D011627:Puberty / Q000502:physiology*; D012074:Remission Induction; D012189:Retrospective Studies
chemical_list: D013956:Antithyroid Agents