5-Alkyl-2-ferrocenyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives inhibit growth of lung cancer A549 cell by inducing apoptosis.
we found that 5-alkyl-2-ferrocenyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives 8d, 8e and 8f could effectively induce apoptosis in A549 lung cancer cells and elevate the levels of integrin beta4 and ROS. The data suggested that these compounds might be promising agents for the cancer therapy, and these compounds would be useful tools for further investigate the functions of integrin beta4 in regulation of the cancer cell apoptosis.
Pan
Xiao-Hong
XH
Institute of Developmental Biology, School of Life Science, Shandong University, Jinan 250100, China.
Liu
Xia
X
Zhao
Bao-Xiang
BX
Xie
Yong-Sheng
YS
Shin
Dong-Soo
DS
Zhang
Shang-Li
SL
Zhao
Jing
J
Miao
Jun-Ying
JY
D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005296:Ferrous Compounds / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D039663:Integrin beta4 / Q000235:genetics / Q000378:metabolism; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D015394:Molecular Structure; D011719:Pyrazines / Q000737:chemistry* / Q000494:pharmacology*; D011720:Pyrazoles / Q000737:chemistry* / Q000494:pharmacology*; D034741:RNA, Small Interfering / Q000235:genetics; D017382:Reactive Oxygen Species / Q000378:metabolism; D013329:Structure-Activity Relationship
D005296:Ferrous Compounds; D039663:Integrin beta4; D011719:Pyrazines; D011720:Pyrazoles; D034741:RNA, Small Interfering; D017382:Reactive Oxygen Species