[Effects of the corticoliberin on synaptic transmission in the rat olfactory cortex slices in water-immersion model depression].
Corticoliberin (corticotrophin-releasing hormone, CRH) regulated of endocrine, autonomic and immune response to stress and is a mediator of anxiety in behavioral response. We studied the effect of corticoliberin on neuronal activity after microstimulation of olfactory cortex slices. Wistar rats strain were selected in T-maze labyrinth according to active and passive strategy of the adaptive behavior. The rats were exposed to water-immersions stress and after 10 days from their brain the olfactory cortex slices were prepared. The evoked focal potential were registered after perfusion with 0.1 mcM of CRH. It was revealed that in 60% of the slices of the active rats CRH induced the small decrease of excitatory amplitude but the increase amplitude inhibitory postsynaptic potential. In 40%, CRH induced the depression of synaptic transmission. Addition of CRH in incubation medium of the passive rat slices related, blockade the synaptic transmission.
Shaliapina
V G
VG
Mokrushin
A A
AA
Kama-Murad
A Kh
AKh
Semenova
O G
OG
D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology*; D003863:Depression / Q000473:pathology / Q000503:physiopathology*; D004195:Disease Models, Animal; D005071:Evoked Potentials / Q000187:drug effects*; D006728:Hormones / Q000494:pharmacology*; D008297:Male; D042282:Microdissection; D009833:Olfactory Pathways / Q000473:pathology / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D009435:Synaptic Transmission / Q000187:drug effects*
D006728:Hormones; D003346:Corticotropin-Releasing Hormone