title: Amiodaron treatment and thyroid autoimmunity markers.
abstract: Autoimmune diseases of the thyroid gland (ADTG) which include, Graves' disease, Hashimoto thyroiditis, primary hypothyroidism with atrophic thyroiditis, postpartum thyroiditis and 'silent' thyroiditis, are characterized by the presence of serum thyroid autoantibodies (TAB). Thyroid autoantibodies are not rare even in the general population of all ages, and their presence in women is 5 times more than in men. The aim of our study was to define the prevalence of thyroid autoantibodies in patients on chronic treatment by amiodarone (AMD), an antiarrhythmic drug rich in iodine, with a potential cytotoxic effect. We have used a section study during a period of two years. Ninety six consecutive patients under AMD treatment were studied, 55 men and 41 women (mean age 62.2 years, range 26-82 years) who referred to us to study their thyroid function. Our results showed that antithyroid antibodies in patients under AMD treatment, with or without thyroid dysfunction, were in similar concentrations as in the general population. A statistically significant greater frequency of increased thyroid peroxidase antibodies (TPOAb) was present in female patients under AMD treatment. When AMD treatment lasted longer than 24 months, the TPOAb were statically higher as compared to those patients under AMD treatment for less than 24 months.
authors.affiliation: Nuclear Medicine Service of Health Center Zajećar, Novo Nordisk Pharma d.o.o. Belgrade, Serbia. lukaal@ptt.yu
authors.forename: Zeljka
authors.initials: Z
authors.lastname: Aleksić
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Aleksić
authors.forename: Vladimir
authors.initials: V
authors.lastname: Mitov
authors.forename: Miljan
authors.initials: M
authors.lastname: Jović
authors.forename: Dragan
authors.initials: D
authors.lastname: Zdravković
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000638:Amiodarone / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013961:Thyroid Gland / Q000187:drug effects* / Q000276:immunology*; D013967:Thyroiditis, Autoimmune / Q000139:chemically induced* / Q000276:immunology*
chemical_list: D000889:Anti-Arrhythmia Agents; D001323:Autoantibodies; D000638:Amiodarone