title: Drosophila SIN3 is required at multiple stages of development.
abstract: SIN3 is a component of a histone deacetylase complex known to be important for transcription repression. While multiple isoforms of SIN3 have been reported, little is known about their relative expression or role in development. Using a combination of techniques, we have determined that SIN3 is expressed throughout the Drosophila life cycle. The pattern of expression for each individual isoform, however, is distinct. Knock down of all SIN3 expression reveals a requirement for this protein in embryonic and larval periods. Taken together, the data suggest that SIN3 is required for multiple developmental events during the Drosophila life cycle.
authors.affiliation: Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA.
authors.forename: Vishal
authors.initials: V
authors.lastname: Sharma
authors.forename: Aishwarya
authors.initials: A
authors.lastname: Swaminathan
authors.forename: Riyue
authors.initials: R
authors.lastname: Bao
authors.forename: Lori A
authors.initials: LA
authors.lastname: Pile
mesh_terms: D017398:Alternative Splicing / Q000235:genetics; D000818:Animals; D019521:Body Patterning; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D005260:Female; D018507:Gene Expression Regulation, Developmental; D008297:Male; D009154:Mutation / Q000235:genetics; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D056264:Sin3 Histone Deacetylase and Corepressor Complex; D014158:Transcription, Genetic / Q000235:genetics
chemical_list: D012097:Repressor Proteins; C099683:SIN3A transcription factor; D056264:Sin3 Histone Deacetylase and Corepressor Complex