title: Drug-induced hyperbilirubinemia and the clinical influencing factors.
abstract: Hyperbilirubinemia may accompany harmful effects such as jaundice, brain dysfunction, and pharmacokinetic alterations of drugs. Clinical drugs are the important causes of hyperbilirubinemia, especially for patients with certain pathologic conditions or with genetic variations. This article reviews hyperbilirubinemic pathophysiology with respect to the effects of clinical drugs. In addition, this review introduces a new formula that may be utilized to estimate the annual occurrences of drug-induced hyperbilirubinemia in a hospital. Variations in the genes of UDP-glucuronosyltransferases, organic anion-transporting polypeptides and multidrug resistance proteins are the predisposing factors for drug-induced hyperbilirubinemia; therefore, their genetic and ethnic polymorphisms are discussed.
authors.affiliation: Department of Pharmacy, Seoul National University Hospital, Seoul, Korea.
authors.forename: Young-Mi
authors.initials: YM
authors.lastname: Ah
authors.forename: Young-Mi
authors.initials: YM
authors.lastname: Kim
authors.forename: Min-Jung
authors.initials: MJ
authors.lastname: Kim
authors.forename: Young Hee
authors.initials: YH
authors.lastname: Choi
authors.forename: Kyoung-Ho
authors.initials: KH
authors.lastname: Park
authors.forename: In-Ja
authors.initials: IJ
authors.lastname: Son
authors.forename: Sang Geon
authors.initials: SG
authors.lastname: Kim
mesh_terms: D000818:Animals; D064420:Drug-Related Side Effects and Adverse Reactions; D014453:Glucuronosyltransferase / Q000235:genetics / Q000378:metabolism; D006801:Humans; D006932:Hyperbilirubinemia / Q000139:chemically induced* / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D007565:Jaundice / Q000139:chemically induced / Q000201:enzymology / Q000235:genetics / Q000378:metabolism; D011110:Polymorphism, Genetic / Q000187:drug effects / Q000502:physiology
chemical_list: D014453:Glucuronosyltransferase