Subcellular alterations that lead to diarrhea during bacterial pathogenesis.
Pathogenic microorganisms routinely exploit host cellular functions for their benefit. These alterations often enhance the survival and/or dissemination of the pathogen. However, these effects on the host can be quite debilitating. Consequently, an in-depth understanding of the molecular mechanisms employed by pathogens to manipulate their hosts is crucial. One of the common host phenotypes elicited by enteric pathogens is the generation of diarrhea. Here, we overview the current advances in understanding strategies used by bacterial pathogens to cause diarrheal diseases and discuss how the coordination of various subcellular events can influence disease progression.
Guttman
Julian A
JA
Simon Fraser University, Department of Biological Sciences, Shrum Science Centre, Room B8276, Burnaby, BC V5A 1S6, Canada. jguttman@sfu.ca
Finlay
B Brett
BB
D000818:Animals; D001419:Bacteria / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*; D001424:Bacterial Infections / Q000382:microbiology*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D001427:Bacterial Toxins / Q000235:genetics / Q000378:metabolism; D003967:Diarrhea / Q000382:microbiology*; D041981:Gastrointestinal Tract / Q000382:microbiology; D054884:Host-Pathogen Interactions; D006801:Humans; D019108:Tight Junctions / Q000382:microbiology
D001426:Bacterial Proteins; D001427:Bacterial Toxins