title: Liver fat, visceral adiposity, and sleep disturbances contribute to the development of insulin resistance and glucose intolerance in nondiabetic dialysis patients.
abstract: Hemodialysis patients exhibit insulin resistance (IR) in target organs such as liver, muscles, and adipose tissue. The aim of this study was to identify contributors to IR and to develop a model for predicting glucose intolerance in nondiabetic hemodialysis patients. After a 2-h, 75-g oral glucose tolerance test (OGTT), 34 hemodialysis patients were divided into groups with normal (NGT) and impaired glucose tolerance (IGT). Indices of insulin sensitivity were derived from OGTT data. Measurements included liver and muscle fat infiltration and central adiposity by computed tomography scans, body composition by dual energy X-ray absorptiometer, sleep quality by full polysomnography, and functional capacity and quality of life (QoL) by a battery of exercise tests and questionnaires. Cut-off points, as well as sensitivity and specificity calculations were based on IR (insulin sensitivity index by Matsuda) using a receiver operator characteristics (ROC) curve analysis. Fifteen patients were assigned to the IGT, and 19 subjects to the NGT group. Intrahepatic fat content and visceral adiposity were significantly higher in the IGT group. IR indices strongly correlated with sleep disturbances, visceral adiposity, functional capacity, and QoL. Visceral adiposity, O2 desaturation during sleep, intrahepatic fat content, and QoL score fitted into the model for predicting glucose intolerance. A ROC curve analysis identified an intrahepatic fat content of > 3.97% (sensitivity, 100; specificity, 35.7) as the best cutoff point for predicting IR. Visceral and intrahepatic fat content, as well as QoL and sleep seemed to be involved at some point in the development of glucose intolerance in hemodialysis patients. Means of reducing fat depots in the liver and splachnic area might prove promising in combating IR and cardiovascular risk in hemodialysis patients.
authors.affiliation: Department of Nephrology, University of Thessaly, Larissa, Greece. gsakkas@med.uth.gr
authors.forename: Giorgos K
authors.initials: GK
authors.lastname: Sakkas
authors.forename: Christina
authors.initials: C
authors.lastname: Karatzaferi
authors.forename: Elias
authors.initials: E
authors.lastname: Zintzaras
authors.forename: Christoforos D
authors.initials: CD
authors.lastname: Giannaki
authors.forename: Vassilios
authors.initials: V
authors.lastname: Liakopoulos
authors.forename: Eleftherios
authors.initials: E
authors.lastname: Lavdas
authors.forename: Eleni
authors.initials: E
authors.lastname: Damani
authors.forename: Nikos
authors.initials: N
authors.lastname: Liakos
authors.forename: Ioannis
authors.initials: I
authors.lastname: Fezoulidis
authors.forename: Yiannis
authors.initials: Y
authors.lastname: Koutedakis
authors.forename: Ioannis
authors.initials: I
authors.lastname: Stefanidis
mesh_terms: D015502:Absorptiometry, Photon; D050154:Adiposity; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D018149:Glucose Intolerance / Q000209:etiology* / Q000503:physiopathology; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008099:Liver / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D018482:Muscle, Skeletal / Q000503:physiopathology; D009752:Nutritional Status; D017286:Polysomnography; D011237:Predictive Value of Tests; D011788:Quality of Life; D012372:ROC Curve; D006435:Renal Dialysis; D018570:Risk Assessment; D012307:Risk Factors; D012893:Sleep Wake Disorders / Q000150:complications* / Q000503:physiopathology; D011795:Surveys and Questionnaires; D014057:Tomography, X-Ray Computed; D055815:Young Adult