title: Prevention of posttransplant cytomegalovirus disease and related outcomes with valganciclovir: a systematic review.
abstract: The precise impact of valganciclovir as preventive therapy for cytomegalovirus (CMV) in solid organ transplant (SOT) recipients is not fully defined. Data from studies using valganciclovir as preemptive therapy or prophylaxis for CMV in SOT recipients were synthesized for descriptive analysis. CMV disease occurred in 2.6% and 9.9% of the patients receiving valganciclovir as preemptive therapy and prophylaxis, respectively. Although the incidence of early-onset (<or=90 days posttransplant) CMV disease was only 0.8% and 1.2% in all patients and R-/D+ patients receiving valganciclovir prophylaxis, the incidence of late-onset (>90 days posttransplant) CMV disease rose up to 8.9% and 17.7% in the prophylactic group, respectively. On the contrary, no patients developed late-onset CMV disease in preemptive group. Both approaches with valganciclovir have successfully decreased CMV disease in SOT recipients. Late-onset CMV disease is a complication observed uniquely with valganciclovir prophylaxis, particularly in R-/D+ patients, but not with preemptive therapy.
authors.affiliation: National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
authors.forename: H-Y
authors.initials: HY
authors.lastname: Sun
authors.forename: M M
authors.initials: MM
authors.lastname: Wagener
authors.forename: N
authors.initials: N
authors.lastname: Singh
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage*; D003587:Cytomegalovirus / Q000378:metabolism; D003586:Cytomegalovirus Infections / Q000517:prevention & control*; D015774:Ganciclovir / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006801:Humans; D007674:Kidney Diseases / Q000628:therapy / Q000821:virology*; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000379:methods*; D008107:Liver Diseases / Q000628:therapy / Q000821:virology*; D016031:Liver Transplantation / Q000009:adverse effects* / Q000379:methods*; D012306:Risk; D013997:Time Factors; D014181:Transplantation Immunology; D016896:Treatment Outcome; D000077562:Valganciclovir; D014773:Virology / Q000379:methods
chemical_list: D000998:Antiviral Agents; D000077562:Valganciclovir; D015774:Ganciclovir