title: Prevalence of pancreatic cystic lesions including intraductal papillary mucinous neoplasms in patients with end-stage renal disease on hemodialysis.
abstract: OBJECTIVE
  Pancreatic cystic (PC) lesions are not necessarily rare, and it is important to diagnose whether PC lesions are neoplastic such as intraductal papillary mucinous neoplasm (IPMN) because of its malignant potential. Reports on PC lesions in hemodialysis (HD) patients are remarkably limited. The aim of this study was to clarify the prevalence and characteristics of PC lesions in HD patients.
  
  
  METHODS
  We reviewed 1012 consecutive HD patients and 11,100 patients (controls) without renal disease who underwent transabdominal ultrasonography between January 2003 and December 2005. Patients' sex ratio (female-to-male) was less, and the age was older in HD patients. Clinical findings of these patients were examined.
  
  
  RESULTS
  The prevalence both of PC lesions and IPMNs was significantly higher in HD patients than in controls (9.3% vs 1.3% and 2.8% vs 0.2%, P < 0.0001). The incidence of IPMNs in HD patients with PC lesions was higher than that in controls with PC lesions (29.8% vs 17.0%, P = 0.021). Multivariate logistic regression analysis revealed that the odds ratios of PC lesions and IPMNs were 6.38 (95% confidence interval, 4.82-8.45) and 9.39 (95% confidence interval, 5.36-16.49) in HD patients compared with controls.
  
  
  CONCLUSIONS
  The prevalence of PC lesions in HD patients is higher, and HD patients with PC lesions have high prevalence of IPMNs.
authors.affiliation: Department of Gastroenterology, Nagoya Kyoritsu Hospital, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Kinichi
authors.initials: K
authors.lastname: Takeda
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Itoh
authors.forename: Tadashi
authors.initials: T
authors.lastname: Imaizumi
authors.forename: Kenji
authors.initials: K
authors.lastname: Oguri
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takahashi
authors.forename: Hirotake
authors.initials: H
authors.lastname: Kasuga
authors.forename: Takanobu
authors.initials: T
authors.lastname: Toriyama
authors.forename: Seiichi
authors.initials: S
authors.lastname: Matsuo
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Hirooka
authors.forename: Akihiro
authors.initials: A
authors.lastname: Itoh
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kawashima
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Kasugai
authors.forename: Eizaburo
authors.initials: E
authors.lastname: Ohno
authors.forename: Ryoji
authors.initials: R
authors.lastname: Miyahara
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Ishigami
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Katano
authors.forename: Naoki
authors.initials: N
authors.lastname: Ohmiya
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Niwa
authors.forename: Hidemi
authors.initials: H
authors.lastname: Goto
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000453:epidemiology*; D000328:Adult; D000368:Aged; D021441:Carcinoma, Pancreatic Ductal / Q000453:epidemiology*; D002291:Carcinoma, Papillary / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010181:Pancreatic Cyst / Q000453:epidemiology*; D010190:Pancreatic Neoplasms / Q000453:epidemiology*; D015995:Prevalence; D006435:Renal Dialysis