title: Lowering of intraocular pressure by topical application of Daucus carota seed extract in rabbits.
abstract: In normotensive rabbits topical application of Daucus carota seed extract at the concentration of 0.3, 0.6 and 1.2% resulted in mean IOP reduction of 19.33. 23.20 and 25.61% respectively from baseline. As no significant difference was observed between the change in IOP in 0.6 and 1.2% extract treated groups, 0.6% concentration was chosen for further evaluation in rabbits with experimentally elevated IOP. In water loaded rabbits, maximum mean IOP reduction with 0.6% extract was 29.39%, which was comparable to pilocarpine. In steroid pretreated rabbits, maximum mean IOP reduction was 30.27% from baseline, which was significantly higher than pilocarpine. The extract showed a comparatively slower onset of action however, the duration of action was comparable to pilocarpine in all the experimental models.
authors.affiliation: Department of Pharmacology, Delhi Institute of Pharmaceutical Sciences & Research, Pushp Vihar, Sector 3, MB Road, New Delhi 110 017, India.
authors.forename: Renu
authors.initials: R
authors.lastname: Agarwal
authors.forename: S K
authors.initials: SK
authors.lastname: Gupta
authors.forename: Sushma
authors.initials: S
authors.lastname: Srivastava
authors.forename: S S
authors.initials: SS
authors.lastname: Agrawal
authors.forename: Rohit
authors.initials: R
authors.lastname: Saxena
mesh_terms: D000818:Animals; D018552:Daucus carota / Q000737:chemistry*; D005123:Eye / Q000187:drug effects; D007429:Intraocular Pressure / Q000187:drug effects*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D011817:Rabbits; D012639:Seeds / Q000737:chemistry*
chemical_list: D010936:Plant Extracts