title: [Research progress in cardiac biological pacemaker created by cell transplantation].
abstract: OBJECTIVE
  To review the current status and problems in developing cardiac biological pacemaker (CBP) by cell transplantation.
  
  
  METHODS
  The literature over the past decade concerning CBP constructed through cell transplantation was reviewed and summarized.
  
  
  RESULTS
  Experiments in vivo testified that the cell transplantation was feasible for CBP construction, and the transplantation of sinus atrial node cell and stem cell was still the predominant method for constructing CBP. However, such problems as difficult amplification of transferred cardio muscle cell, low success rate of CBP construction as well as unstable function of CBP make it lag behind the tremendous clinical demands. The gene transfection technology might be one of the approaches to resolve these issues.
  
  
  CONCLUSIONS
  As one feasible method for CBP construction, the cell transplantation has a bright future in the clinical application and is worthy of further study.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Affiliated Hospital of Luzhou Medical College, Luzhou Sichuan, 646000, P.R. China. fyon001122@163.com
authors.forename: Yong
authors.initials: Y
authors.lastname: Fu
authors.forename: Fengxu
authors.initials: F
authors.lastname: Yu
authors.forename: Bin
authors.initials: B
authors.lastname: Liao
mesh_terms: D000818:Animals; D002304:Cardiac Pacing, Artificial; D017690:Cell Transplantation; D006801:Humans; D010138:Pacemaker, Artificial