Nanotechnologic biosensor ellipsometry and biomarker pattern analysis in the evaluation of atherosclerotic risk profile.
A proteoheparan sulfate coated, hydrophobic silica surface serves as lipoprotein receptor at which the Ca(2+)-driven arteriosclerotic nanoplaque formation can be pursued by laser-based ellipsometry. Any lipoprotein from human blood can be very sensitively tested for its atherogenic properties. From the same blood sample, it is possible to determine the concentration and activity of a series of interacting biomarker molecules which, through a pattern analysis, allow to assess the state of health with respect to cardiovascular diseases. These two interlinked and complementary biosensors make a prospective cardio-cerebro-vascular risk stratification feasible, especially the sequelae of an underlying arteriosclerotic disease. Based on these diagnostic tools, an optimized therapy decision for the patient can be taken and the necessary preventive measures for the still healthy person.
Siegel
G
G
Charité - University Clinic Berlin, Institute of Physiology, D-14195 Berlin, Germany.
Rodríguez
M
M
Sauer
F
F
Abletshauser
C
C
de Mey
C
C
Schötz
K
K
Ringstad
L
L
Malmsten
M
M
Schäfer
P
P
D050197:Atherosclerosis / Q000175:diagnosis* / Q000378:metabolism*; D015415:Biomarkers / Q000032:analysis; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D008074:Lipoproteins / Q000032:analysis*; D036103:Nanotechnology / Q000295:instrumentation*; D010363:Pattern Recognition, Automated / Q000379:methods*; D012031:Refractometry / Q000295:instrumentation*; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D012680:Sensitivity and Specificity
D015415:Biomarkers; D008074:Lipoproteins