title: MSX-3D: a tool to validate 3D protein models using mass spectrometry.
abstract: BACKGROUND
  The technique of chemical cross-linking followed by mass spectrometry has proven to bring valuable information about the protein structure and interactions between proteic subunits. It is an effective and efficient way to experimentally investigate some aspects of a protein structure when NMR and X-ray crystallography data are lacking.
  
  
  RESULTS
  We introduce MSX-3D, a tool specifically geared to validate protein models using mass spectrometry. In addition to classical peptides identifications, it allows an interactive 3D visualization of the distance constraints derived from a cross-linking experiment.
  
  
  BACKGROUND
  Freely available at http://proteomics-pbil.ibcp.fr
authors.affiliation: Institut de Biologie et Chimie des Protéines (IBCP) UMR5086 CNRS, Université Lyon 1, France.
authors.forename: Michaël
authors.initials: M
authors.lastname: Heymann
authors.forename: David
authors.initials: D
authors.lastname: Paramelle
authors.forename: Gilles
authors.initials: G
authors.lastname: Subra
authors.forename: Eric
authors.initials: E
authors.lastname: Forest
authors.forename: Jean
authors.initials: J
authors.lastname: Martinez
authors.forename: Christophe
authors.initials: C
authors.lastname: Geourjon
authors.forename: Gilbert
authors.initials: G
authors.lastname: Deléage
mesh_terms: D003198:Computer Simulation; D030562:Databases, Protein; D013058:Mass Spectrometry / Q000379:methods*; D008958:Models, Molecular; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry; D040901:Proteomics / Q000379:methods; D012984:Software
chemical_list: D011506:Proteins