title: Structure and properties of strontium-doped phosphate-based glasses.
abstract: Owing to similarity in both ionic size and polarity, strontium (Sr2+) is known to behave in a comparable way to calcium (Ca2+), and its role in bone metabolism has been well documented as both anti-resorptive and bone forming. In this study, novel quaternary strontium-doped phosphate-based glasses, containing 1, 3 and 5 mol% SrO, were synthesized and characterized. (31)P magic angle spinning (MAS) nuclear magnetic resonance results showed that, as the Sr2+ content is increased in the glasses, there is a slight increase in disproportionation of Q2 phosphorus environments into Q(1) and Q3 environments. Moreover, shortening and strengthening of the phosphorus to bridging oxygen distance occurred as obtained from FTIR. The general broadening of the spectral features with Sr2+ content is most probably due to the increased variation of the phosphate-cation bonding interactions caused by the introduction of the third cation. This increased disorder may be the cause of the increased degradation of the Sr-containing glasses relative to the Sr-free glass. As confirmed from elemental analysis, all Sr-containing glasses showed higher Na2O than expected and this also could be accounted for by the higher degradation of these glasses compared with Sr-free glasses. Measurements of surface free energy (SFE) showed that incorporation of strontium had no effect on SFE, and samples had relatively higher fractional polarity, which is not expected to promote high cell activity. From viability studies, however, the incorporation of Sr2+ showed better cellular response than Sr(2+)-free glasses, but still lower than the positive control. This unfavourable cellular response could be due to the high degradation nature of these glasses and not due to the presence of Sr2+.
authors.affiliation: Division of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, 256 Gray's Inn Road, London WC1X 8LD, UK.
authors.forename: Ensanya A
authors.initials: EA
authors.lastname: Abou Neel
authors.forename: Wojciech
authors.initials: W
authors.lastname: Chrzanowski
authors.forename: David M
authors.initials: DM
authors.lastname: Pickup
authors.forename: Luke A
authors.initials: LA
authors.lastname: O'Dell
authors.forename: Nicola J
authors.initials: NJ
authors.lastname: Mordan
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Newport
authors.forename: Mark E
authors.initials: ME
authors.lastname: Smith
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Knowles
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D001709:Biotechnology; D002448:Cell Adhesion; D002470:Cell Survival; D005898:Glass / Q000737:chemistry*; D006801:Humans; D008279:Magnetic Resonance Imaging; D010087:Oxides / Q000032:analysis; D010710:Phosphates / Q000737:chemistry*; D017670:Sodium Compounds / Q000032:analysis; D017550:Spectroscopy, Fourier Transform Infrared; D013324:Strontium / Q000737:chemistry*; D013499:Surface Properties; D014407:Tumor Cells, Cultured; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D010087:Oxides; D010710:Phosphates; D017670:Sodium Compounds; C096707:sodium oxide; D013324:Strontium