title: Deep juvenile xanthogranuloma presenting as a chest wall mass: a case report.
abstract: BACKGROUND
  Juvenile xanthogranulotna (JXG) is a non-Langerhans cell histocytic proliferation that may appear as an extracutaneous deep-seated lesion and give a broad clinical dijffrrential diagnosis. We report the fine needle aspiration cytologv (FNAC) findings of deep JXG.
  
  
  METHODS
  A 5-month-old African-American boy was incidentally found to have a chest wall mass on a chest radiograph obtained for an unrelated medical problem. Subsequent computed tomographic scans documented a 3.8-cm soft tissue mass that involved the right chest wall centered around the fifth rib. A broad clinical differential diagnosis prompted FNA to evaluate the lesion. Aspirate smears of the mass exhibited numerous finely vacuolated histocytes, eosinophils, multinucleated giant cells and scattered Touton giant cells. Many of the histiocytes had reniform or grooved nuclei, resembling Langerhans cells. The histiocytes were immunoreactive for CD68 but were nonreactive for CD1a and S-100 protein. Subsequent excisional biopsy confirmed the diagnosis of JXG. In addition, the tumor was strongly immunoreactive for factor XIIIa.
  
  
  CONCLUSIONS
  JXG should be considered in the diferential diagnosis of any histocytic/fibrohistiocytic soft tissue lesion of childhood, and this entity can be accurately diagnosed by FNAC and immunohistochemical findings.
authors.affiliation: Department of Pathology, Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina, USA. lihon@med.umich.edu
authors.forename: Hong C
authors.initials: HC
authors.lastname: Li
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Roux
authors.forename: Thomas
authors.initials: T
authors.lastname: Pranikoff
authors.forename: Scott E
authors.initials: SE
authors.lastname: Kilpatrick
authors.forename: James O
authors.initials: JO
authors.lastname: Cappellari
mesh_terms: D044963:Biopsy, Fine-Needle; D003937:Diagnosis, Differential; D006801:Humans; D007223:Infant; D008297:Male; D035441:Thoracic Wall / Q000473:pathology*; D014972:Xanthogranuloma, Juvenile / Q000175:diagnosis / Q000473:pathology*