title: Full-length genome characterization of an HIV type 2 isolate from India.
abstract: An infectious Indian human immunodeficiency virus-2 (HIV-2) subtype A isolate was completely sequenced and analyzed and its phylogenetic relatedness was investigated. The unusual limited size of the long terminal repeat (LTR) from the isolate was caused due to a truncation within the nef open reading frame (ORF) located at the U3 region of the LTR. The genetic relatedness and lineage of this HIV-2 strain were investigated. The close relatedness of this isolate to West African HIV-2 isolates confirms a geographical entry route of HIV-2 to this part of the Indian subcontinent. This is the first report of an HIV-2 full genome analysis from the Indian subcontinent as well as from Asia.
authors.affiliation: Virology Laboratory, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Kharghar, Navi Mumbai-410210, India.
authors.forename: C V
authors.initials: CV
authors.lastname: Santhosh
authors.forename: Mayur C
authors.initials: MC
authors.lastname: Tamhane
authors.forename: Rita
authors.initials: R
authors.lastname: Mukhopadhyaya
authors.forename: Robin
authors.initials: R
authors.lastname: Mukhopadhyaya
mesh_terms: D016000:Cluster Analysis; D016679:Genome, Viral; D005838:Genotype; D015658:HIV Infections / Q000821:virology*; D015498:HIV-2 / Q000235:genetics* / Q000302:isolation & purification*; D006801:Humans; D007194:India; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics*; D017422:Sequence Analysis, DNA
chemical_list: D012367:RNA, Viral