title: Cycloartane glycosides from Astragalus campylosema Boiss. ssp. campylosema.
abstract: Four cycloartane glycosides, 3-O-[alpha-l-arabinopyranosyl-(1-->2)-beta-d-xylopyranosyl]-3beta,6alpha,16beta,23alpha,25-pentahydroxy-20(R),24(S)-epoxycycloartane (1), 3-O-[alpha-l-arabinopyranosyl-(1-->2)-beta-d-xylopyranosyl]-16-O-hydroxyacetoxy-23-O-acetoxy-3beta,6alpha,25-trihydroxy-20(R),24(S)-epoxycycloartane (2), 3-O-[alpha-l-arabinopyranosyl-(1-->2)-beta-d-xylopyranosyl]-3beta,6alpha,23alpha,25-tetrahydroxy-20(R),24(R)-16beta,24;20,24-diepoxycycloartane (3), 3-O-[alpha-l-arabinopyranosyl-(1-->2)-beta-d-xylopyranosyl]-25-O-beta-d-glucopyranosyl-3beta,6alpha,16beta,25-tetrahydroxy-20(R),24(S)-epoxycycloartane (4), along with three known cycloartane glycosides were isolated from the MeOH extract of the roots of Astragalus campylosema ssp. campylosema. Their structures were established by the extensive use of 1D- and 2D-NMR experiments along with ESIMS and HRMS analysis. The occurrence of the hydroxyl function at position 23 (1-2) and of the ketalic function at C-24 (3) are very unusual findings in the cycloartane class.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, TR-06100 Ankara, Turkey. icalis@hacettepe.edu.tr
authors.forename: Ihsan
authors.initials: I
authors.lastname: Caliş
authors.forename: Ali A
authors.initials: AA
authors.lastname: Dönmez
authors.forename: Angela
authors.initials: A
authors.lastname: Perrone
authors.forename: Cosimo
authors.initials: C
authors.lastname: Pizza
authors.forename: Sonia
authors.initials: S
authors.lastname: Piacente
mesh_terms: D027883:Astragalus Plant / Q000737:chemistry*; D001688:Biological Products / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry*
chemical_list: D001688:Biological Products; D006027:Glycosides; D010936:Plant Extracts; D014315:Triterpenes; C085352:cycloartane