title: A comparison of hypoglycemic activity of three species of basidiomycetes rich in vanadium.
abstract: The hypoglycemic activity of fermented mushroom of three fungi of basidiomycetes rich in vanadium was studied in this paper. Alloxan- and adrenalin-induced hyperglycemic mice were used in the study. The blood glucose and the sugar tolerance were determined. After the mice were administered (ig) with Coprinus comatus rich in vanadium, the blood glucose of alloxan-induced hyperglycemic mice decreased (p < 0.05), ascension of blood glucose induced by adrenalin was inhibited (p < 0.01) and the sugar tolerance of the normal mice was improved. However, the same result did not occur in Ganoderma lucidum and Grifola frondosa group. Compared with Ganoderma rich in vanadium and Grifola frondosa rich in vanadium, the hypoglycemic effects of Coprinus comatus rich in vanadium on hyperglycemic animals are significant; it may be used as a hypoglycemic food or medicine for hyperglycemic people.
authors.affiliation: School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355, People's Republic of China. sdscipaper@126.com
authors.forename: Chunchao
authors.initials: C
authors.lastname: Han
authors.forename: Tongjun
authors.initials: T
authors.lastname: Liu
mesh_terms: D000496:Alloxan; D000704:Analysis of Variance; D000818:Animals; D001487:Basidiomycota / Q000737:chemistry*; D001786:Blood Glucose / Q000032:analysis*; D001835:Body Weight / Q000187:drug effects; D003302:Coprinus / Q000737:chemistry; D004837:Epinephrine / Q000494:pharmacology; D005285:Fermentation; D048691:Grifola / Q000737:chemistry; D006943:Hyperglycemia / Q000097:blood / Q000139:chemically induced; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D051379:Mice; D020940:Reishi / Q000737:chemistry; D014639:Vanadium / Q000008:administration & dosage / Q000032:analysis / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D014639:Vanadium; D000496:Alloxan; D004837:Epinephrine