Quantitative spectroscopic imaging for non-invasive early cancer detection.
We report a fully quantitative spectroscopy imaging instrument for wide area detection of early cancer (dysplasia). This instrument provides quantitative maps of tissue biochemistry and morphology, making it a potentially powerful surveillance tool for objective early cancer detection. We describe the design, construction, calibration, and first clinical application of this new system. We demonstrate its accuracy using physical tissue models. We validate its diagnostic ability on a resected colon adenoma, and demonstrate feasibility of in vivo imaging in the oral cavity.
Yu
Chung-Chieh
CC
George R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. chungyu@mit.edu
Lau
Condon
C
O'Donoghue
Geoffrey
G
Mirkovic
Jelena
J
McGee
Sasha
S
Galindo
Luis
L
Elackattu
Alphi
A
Stier
Elizabeth
E
Grillone
Gregory
G
Badizadegan
Kamran
K
Dasari
Ramachandra R
RR
Feld
Michael S
MS
D000236:Adenoma / Q000175:diagnosis* / Q000473:pathology; D002138:Calibration; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000473:pathology; D003952:Diagnostic Imaging / Q000379:methods; D004867:Equipment Design; D006801:Humans; D008403:Mass Screening / Q000379:methods*; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D055095:Optics and Photonics; D019047:Phantoms, Imaging; D011230:Precancerous Conditions / Q000175:diagnosis; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D013057:Spectrum Analysis / Q000295:instrumentation* / Q000379:methods