Synthesis, anti-bacterial and anti-oxidant properties of thiadiazaphosphol-2-ones.
4-Amino-5-phenyl-4H-1,2,4-triazole-3-thiol (1) underwent facile condensation with various phosphorus dichlorides (2a-j) in the presence of triethylamine in dry tetrahydrofuran at 60-65 degrees C and afforded corresponding thiadiazaphosphol-2-ones (3a-j). Their chemical structures were characterized using IR, (1)H-, (13)C-, (31)P-NMR and Mass spectral studies. All the title compounds were screened for antioxidant properties by radical scavenging methods such as 1,1-diphenyl-2-picryl hydrazyl (DPPH), hydroxyl and lipid peroxidation. They exhibited potent in vitro antioxidant activity dose dependently. Their bioassay showed them to possess significant antibacterial activity.
Balakrishna
Avula
A
Department of Chemistry, Biochemistry, S.V. University, Tirupati, India.
Reddy
Mudamala Veera Narayana
MV
Nayak
Sandip Kumar
SK
Manjunath
Manubolu
M
Reddy
Chichili Devendranath
CD
Reddy
Cirandur Suresh
CS
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000737:chemistry; D001419:Bacteria / Q000187:drug effects; D001713:Biphenyl Compounds; D005290:Ferric Compounds / Q000737:chemistry; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000494:pharmacology; D017665:Hydroxyl Radical / Q000737:chemistry; D015227:Lipid Peroxidation / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D010851:Picrates / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D005290:Ferric Compounds; D016166:Free Radical Scavengers; D009943:Organophosphorus Compounds; D010851:Picrates; D013830:Thiadiazoles; D017665:Hydroxyl Radical; C004931:1,1-diphenyl-2-picrylhydrazyl; D001205:Ascorbic Acid