title: Influence of endosulfan and monocrotophos exposure on the activity of NADPH cytochrome C reductase (NCCR) of Labeo rohita (Ham).
abstract: The response of NADPH cytochrome C reductase (NCCR) activity in liver of Labeo rohita fish exposed to the pesticides, 0.25 microgl(-1) endosulfan and 2 mg/l monocrotophos was studied. In terms of specific enzyme activity (mU/mg protein) a significant level of NCCR was observed in the liver tissues of Labeo rohita exposed to the pesticides, when compared to the control fish (2.460 mU/mg protein). Increase of NCCR activity was more in the liver of the fish exposed to monocrotophos (4.595 mU/mg protein) than those exposed to endosulfan (2.850 mU/mg protein). The results demonstrate that the pesticides, endosulfan and monocrotophos, interfere with NADPH dependent monoxygenase mechanism and are effective inducers of NADPH cytochrome C reductase. The activity of NCCR in the liver tissue of Labeo rohita may serve as a useful tool for monitoring aquatic pollution.
authors.affiliation: Department of Zoology, Andhra University, Visakhapatnam, India.
authors.forename: K
authors.initials: K
authors.lastname: Ramaneswari
authors.forename: L M
authors.initials: LM
authors.lastname: Rao
mesh_terms: D000818:Animals; D049628:Body Size; D001835:Body Weight; D003530:Cyprinidae / Q000378:metabolism*; D004726:Endosulfan / Q000378:metabolism / Q000633:toxicity*; D007306:Insecticides / Q000378:metabolism / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008999:Monocrotophos / Q000378:metabolism / Q000633:toxicity*; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism*; D013997:Time Factors; D014874:Water Pollutants, Chemical / Q000378:metabolism / Q000633:toxicity*
chemical_list: D007306:Insecticides; D014874:Water Pollutants, Chemical; D008999:Monocrotophos; D009251:NADPH-Ferrihemoprotein Reductase; D004726:Endosulfan