[Immunochemical properties of conjugated antigens from N-substituted phenothiazines and dibenzazepines with antiarrhythmic activity].
The use of metabolites of antiarrhythmic drugs (ethmozine, ethacizine, and bonnecor) as haptens in the synthesis of conjugated antigens allowed us to induce the formation of antibodies with different specificity for certain metabolites. A new enzyme immunoassay was developed for the detection of phenothiazine and dibenzazepine derivatives (ethmozine, ethacizine, and bonnecor). Nanogram and subnanogram quantities of these substances may be detected in biological fluids.
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D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000032:analysis* / Q000276:immunology*; D000906:Antibodies / Q000737:chemistry* / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D006241:Haptens / Q000032:analysis* / Q000276:immunology*; D011817:Rabbits; D012680:Sensitivity and Specificity
D000889:Anti-Arrhythmia Agents; D000906:Antibodies; D006241:Haptens