Oxcarbazepine-induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS).
This is an image and brief case report of a 13-year-old boy who presented with severe rash and systemic symptoms after starting oxcarbazepine. The patient was diagnosed and treated for Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), a syndrome of fever, rash, and internal organ involvement secondary to medication administration. The image illustrates the rash seen with this drug reaction. The report is followed by a brief review of anticonvulsant hypersensitivity syndrome and DRESS.
D'Orazio
Joseph L
JL
Department of Emergency Medicine, Division of Medical Toxicology, Drexel University College of Medicine, Philadelphia, PA 19102, USA. joseph.dorazio@drexelmed.edu
D000293:Adolescent; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D002220:Carbamazepine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003875:Drug Eruptions / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D004802:Eosinophilia / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy; D005334:Fever / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D000078330:Oxcarbazepine; D012640:Seizures / Q000188:drug therapy; D016896:Treatment Outcome
D000927:Anticonvulsants; D005938:Glucocorticoids; D002220:Carbamazepine; D000078330:Oxcarbazepine