title: Vitamin E dependent microRNA regulation in rat liver.
abstract: Dietary vitamin E (VE) is known to regulate gene expression by altering mRNA concentrations. Recently, microRNA (miRNA) have been discovered as a means of posttranscriptional gene regulation. Since the effect of VE on miRNA regulation is unknown, we fed rats for 6 months diets deficient or sufficient in VE and determined hepatic concentrations of miRNA involved in processes previously associated with VE (lipid metabolism, miRNA-122a; cancer and inflammation, miRNA-125b). VE-deficiency resulted in reduced concentrations of miRNA-122a and miRNA-125b. The findings of the present study demonstrate that differences in dietary VE may affect hepatic miRNA concentrations in vivo.
authors.affiliation: Institute of Human Nutrition and Food Science, Christian-Albrechts-University of Kiel, Hermann-Rodewald-Strasse 6, 24118 Kiel, Germany.
authors.forename: Sonja
authors.initials: S
authors.lastname: Gaedicke
authors.forename: Xiangnan
authors.initials: X
authors.lastname: Zhang
authors.forename: Constance
authors.initials: C
authors.lastname: Schmelzer
authors.forename: Yijia
authors.initials: Y
authors.lastname: Lou
authors.forename: Frank
authors.initials: F
authors.lastname: Doering
authors.forename: Jan
authors.initials: J
authors.lastname: Frank
authors.forename: Gerald
authors.initials: G
authors.lastname: Rimbach
mesh_terms: D000818:Animals; D001483:Base Sequence; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D004032:Diet; D005786:Gene Expression Regulation / Q000187:drug effects; D007249:Inflammation / Q000235:genetics; D050356:Lipid Metabolism / Q000187:drug effects / Q000235:genetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D035683:MicroRNAs / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344; D014810:Vitamin E / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D035683:MicroRNAs; D014810:Vitamin E