title: Suzuki cross-coupling/reductive debenzyloxycarbonylation sequence for the syntheses of [c]annulated isoquinolines: application for the syntheses of pancratistatin-like isoquinolines.
abstract: A two-step strategy involving Suzuki cross-coupling of boronic acids with a diverse array of alpha-iodoenones followed by hydrogenation is developed for the construction of [c]annulated isoquinolines. This mild and efficient procedure is also applied to the synthesis of highly oxygenated isoquinolines.
authors.affiliation: Division of Organic Chemistry, National Chemical Laboratory, Dr. Homi Bhabha Road, Pune-411008, India. gp.pandey@ncl.res.in
authors.forename: Ganesh
authors.initials: G
authors.lastname: Pandey
authors.forename: Madhesan
authors.initials: M
authors.lastname: Balakrishnan
mesh_terms: D047151:Amaryllidaceae Alkaloids / Q000138:chemical synthesis / Q000737:chemistry*; D001897:Boronic Acids / Q000737:chemistry; D006865:Hydrogenation; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction
chemical_list: D047151:Amaryllidaceae Alkaloids; D001897:Boronic Acids; D007546:Isoquinolines; C044997:pancratistatin