A convenient Negishi protocol for the synthesis of glycosylated oligo(ethynylene)s.
A convenient and efficient sp-sp carbon heterocoupling protocol based on the Negishi reaction was developed, in which the required zinc diacetylide was generated from 1,4-bis(trimethylsilyl)butadiyne in situ and reacted with a bromoacetylene in apolar solvent mixtures. The method has been applied to the synthesis of unsymmetric glycosylated and symmetric diglycosylated oligo(ethynylene)s up to the octa(ethynylene).
Hoheisel
Tobias N
TN
ETH Zürich, Department of Materials, Wolfgang-Pauli-Str. 10, HCI H515, 8093 Zürich, Switzerland.
Frauenrath
Holger
H