PPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain Invasion.
Today, there is increasing evidence that PPARgamma agonists, including thiazolidinediones (TDZs) and nonthiazolidinediones, block the motility and invasiveness of glioma cells and other highly migratory tumor entities. However, the mechanism(s) by which PPARgamma activators mediate their antimigratory and anti-invasive properties remains elusive. This letter gives a short review on the debate and adds to the current knowledge by applying a PPARgamma inactive derivative of the TDZ troglitazone (Rezulin) which potently counteracts experimental glioma progression in a PPARgamma independent manner.
Seufert
Sebastian
S
Institute of Human Genetics, Institute of Genetics, and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Kerpener Street 34, 50931 Cologne, Germany.
Coras
Roland
R
Tränkle
Christian
C
Zlotos
Darius P
DP
Blümcke
Ingmar
I
Tatenhorst
Lars
L
Heneka
Michael T
MT
Hahnen
Eric
E