title: Free fatty acid receptor family: novel targets for the treatment of diabetes and dyslipidemia.
abstract: Free fatty acids (FFAs) fuel physiological processes in various tissues, such as skeletal muscle, the heart, liver and pancreas. Malfunction of FFA-mediated signaling pathways, as well as FFA metabolism, has been correlated to pathologies such as type 2 diabetes and dyslipidemia. The recent deorphanization of the FFA receptor family has drawn attention to these G-protein-coupled receptors as potential therapeutic targets for the treatment of metabolic diseases.
authors.affiliation: Euroscreen SA, Rue Adrienne Bolland 47, 6041 Gosselies, Belgium. jbernard@euroscreen.com
authors.forename: Jerome
authors.initials: J
authors.lastname: Bernard
mesh_terms: D000818:Animals; D003920:Diabetes Mellitus / Q000188:drug therapy*; D050171:Dyslipidemias / Q000188:drug therapy*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D000960:Hypolipidemic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000187:drug effects / Q000235:genetics / Q000378:metabolism
chemical_list: D005230:Fatty Acids, Nonesterified; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled