title: Palladium-catalyzed direct arylation of nitro-substituted aromatics with aryl halides.
abstract: Direct arylation reactions of nitrobenzenes and aryl halides occur in good yield and high ortho regioselectivity. These reactions can be performed on gram scale with as few as 3 equiv of the nitro arene relative to the aryl halide. The synthetic utility of this method is demonstrated via rapid synthesis of a Boscalid intermediate.
authors.affiliation: Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Canada K1N 6N5.
authors.forename: Laurence
authors.initials: L
authors.lastname: Caron
authors.forename: Louis-Charles
authors.initials: LC
authors.lastname: Campeau
authors.forename: Keith
authors.initials: K
authors.lastname: Fagnou
mesh_terms: D002384:Catalysis; D006219:Halogens / Q000737:chemistry*; D015394:Molecular Structure; D009578:Nitrobenzenes / Q000737:chemistry; D017672:Nitrogen Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D006219:Halogens; D009578:Nitrobenzenes; D017672:Nitrogen Compounds; D010165:Palladium; C036077:nitrobenzene