title: [Study on antidepressant components of sucrose ester from Polygala tenuifolia].
abstract: OBJECTIVE
  To investigate the antidepressant components of Polygala tenuifolia.
  
  
  METHODS
  The chromatographic method was used to isolate and purify the chemical constituents, their structures were identified by spectral analysis, MTT method was applied to investigate their cytotoxic activities.
  
  
  RESULTS
  Nine compounds were isolated from the roots of P. tenuifolia. Their structures were identified as sibiricose A, (1), sibiricose A5 (2), tenuifoliside A (3) and 3', 6-disinapoyl sucrose (4), sibiricose A6 (5), 3, 4, 5-trimethoxycinnamate (6), polygalaxanthone III (7), tenuifolioses A (8), tenuifolioses H (9) and some compounds' activities to PC12 were observed.
  
  
  CONCLUSIONS
  Compound 1 was isolated from this plant for the first time. Compounds 2,3 could protect PC12 cells damage induced by P. tenuifolia.
authors.affiliation: Dept of Clinical Pharmacology, General Hospital of PIM, Beijing 100853, China.
authors.forename: Hai-Hua
authors.initials: HH
authors.lastname: Tu
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.forename: Liang
authors.initials: L
authors.lastname: Mu
authors.forename: Hong-Bo
authors.initials: HB
authors.lastname: Liao
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Xie
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Ma
authors.forename: Yao-Ming
authors.initials: YM
authors.lastname: Liu
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004952:Esters / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D016716:PC12 Cells; D018517:Plant Roots / Q000737:chemistry; D031801:Polygala / Q000737:chemistry*; D051381:Rats; D013395:Sucrose / Q000737:chemistry*
chemical_list: D000928:Antidepressive Agents; D004952:Esters; D013395:Sucrose