Brain natriuretic peptide correlates with the extent of atrial fibrillation-associated silent brain lesions.
OBJECTIVE
Identification of plasma markers indicative for atrial fibrillation-associated silent brain lesions.


METHODS
1. Comparative determination of the plasma concentrations of secretagogin, S100B, neuropeptide Y, brain fatty acid binding protein, matrix metalloprotease 9, brain natriuretic peptide, and of D-Dimer in 222 patients with atrial fibrillation and 28 controls by immunoassays. 2. Correlation of the biochemical marker plasma concentration with the extent of silent white matter brain lesions, as determined by the Fazekas score and N-acetylaspartate-spectroscopy.


RESULTS
1. Plasma concentrations of brain natriuretic peptide, of neuropeptide Y, and of matrix metalloprotease 9 were significantly higher (all with a p<0.05) in patients suffering from atrial fibrillation than in control subjects. 2. Brain natriuretic peptide correlated significantly with the Fazekas score (R=0.41; p<0.005). 3. Brain natriuretic peptide plasma concentrations were significantly higher in patients with a pathological N-acetylaspartate magnetic resonance-spectrometry (p<0.05).


CONCLUSIONS
Brain natriuretic peptide plasma concentrations correlate with the extent of atrial fibrillation-associated silent brain lesions.
Gartner
Wolfgang
W
Medical University Vienna, Department of Medicine III, Austria. wolfgang.gartner@bhs.at
Zierhut
Barbara
B
Mineva
Ivelina
I
Sodeck
Gottfried
G
Leutmezer
Fritz
F
Domanovits
Hans
H
Prayer
Daniela
D
Wolf
Florian
F
Base
Wolfgang
W
Weissel
Michael
M
Wagner
Ludwig
L
D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000097:blood / Q000473:pathology; D015415:Biomarkers / Q000097:blood*; D001921:Brain / Q000473:pathology*; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D009478:Neuropeptide Y / Q000097:blood; D012307:Risk Factors
D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; D009478:Neuropeptide Y; C036309:fibrin fragment D; D020097:Natriuretic Peptide, Brain; D020780:Matrix Metalloproteinase 9