title: A facile synthesis of novel biologically active 4-hydroxy-N'-(benzylidene)-2H-benzo[e][1,2]thiazine-3-carbohydrazide 1,1-dioxides.
abstract: A novel series of potentially biologically active 4-hydroxy-N'-(benzylidene)-2H-benzo[e][1,2]thiazine-3-carbohydrazide 1,1-dioxides were synthesized starting from ultrasonic mediated N-alkylation of sodium saccharin with methyl chloroacetate. Ring expansion of methyl(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)acetate followed by its hydrazinolysis afforded 4-hydroxy-2H-1,2-benzothiazine-3-carbohydrazide 1,1-dioxide which was reacted in a straight forward manner with various benzaldehydes in an ultrasonic bath to get the title compounds. All of the synthesized compounds were subjected to preliminary evaluation for their antibacterial and DPPH radical scavenging activities.
authors.affiliation: Applied Chemistry Research Centre, PCSIR Laboratories Complex, Ferozpur Road, Lahore, Punjab 54600, Pakistan. rehman_pcsir@hotmail.com
authors.forename: Muhammad
authors.initials: M
authors.lastname: Zia-ur-Rehman
authors.forename: Jamil Anwar
authors.initials: JA
authors.lastname: Choudary
authors.forename: Mark Robert James
authors.initials: MR
authors.lastname: Elsegood
authors.forename: Hamid Latif
authors.initials: HL
authors.lastname: Siddiqui
authors.forename: Khalid Mohammad
authors.initials: KM
authors.lastname: Khan
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006834:Hydrazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular
chemical_list: D000900:Anti-Bacterial Agents; D006834:Hydrazines; C019289:carbohydrazide