Antibacterial activity of hydroxyalkenyl salicylic acids from sarcotesta of Ginkgo biloba against vancomycin-resistant Enterococcus.
A chloroform fraction prepared from the sarcotesta of Ginkgo biloba showed potent inhibitory activity against vancomycin-resistant Enterococcus (VRE). The active compounds were elucidated to be 2-hydroxy-6-(8-pentadecenyl) salicylic acid (1) and 2-hydroxy-6-(10-heptadecenyl) salicylic acid (2) based on their spectral analysis. Compounds 1 and 2 showed significant antibacterial activities against VRE.
Choi
J G
JG
National Agricultural Products Quality Management Service, Ministry of Agriculture and Forestry, Jeonju 561-823, South Korea.
Jeong
S I
SI
Ku
C S
CS
Sathishkumar
M
M
Lee
J J
JJ
Mun
S P
SP
Kim
S M
SM
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D016983:Enterococcus / Q000187:drug effects*; D020441:Ginkgo biloba / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010936:Plant Extracts / Q000494:pharmacology*; D012459:Salicylates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D012639:Seeds; D020713:Vancomycin Resistance
C539648:2-hydroxy-6-(10-heptadecenyl)salicylic acid; C539647:2-hydroxy-6-(8-pentadecenyl)salicylic acid; D000900:Anti-Bacterial Agents; D010936:Plant Extracts; D012459:Salicylates