title: Evidence that volume of anterior medial temporal lobe is reduced in seniors destined for mild cognitive impairment.
abstract: The present study sought to determine if volumes of specific brain structures could discriminate cognitively normal seniors destined to develop mild cognitive impairment (MCI) within a few years from those who will remain normal. Brain scans were collected from seventy-one cognitively normal seniors. Seventeen individuals later developed MCI (the presymptomatic MCI; pMCI group), while fifty-four remained normal. Whole brain volume (WBV) and volumes of the entorhinal cortex (ERC), hippocampus, and three subregions of the hippocampus (head; HH, body; HB and tail; HT) were compared. Results indicated that the pMCI group had smaller volumes than the normal group in the ERC, HH and HB, but not the HT or WBV. When HH/HB volumes and baseline memory test scores were included in a single logistic regression model, classification accuracy was very high (area under the curve=0.93). These results show that smaller normalized volumes of anterior medial temporal lobe structures contribute to the development of MCI, a finding which may have implications for identifying seniors at risk for cognitive decline.
authors.affiliation: Department of Anatomy and Neurobiology, Chandler Medical Center, University of Kentucky, Lexington, KY 40536-0298, USA.
authors.forename: Sarah B
authors.initials: SB
authors.lastname: Martin
authors.forename: Charles D
authors.initials: CD
authors.lastname: Smith
authors.forename: Heather R
authors.initials: HR
authors.lastname: Collins
authors.forename: Fred A
authors.initials: FA
authors.lastname: Schmitt
authors.forename: Brian T
authors.initials: BT
authors.lastname: Gold
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology* / Q000523:psychology; D000544:Alzheimer Disease / Q000175:diagnosis / Q000473:pathology / Q000523:psychology; D003072:Cognition Disorders / Q000175:diagnosis / Q000473:pathology* / Q000523:psychology; D015331:Cohort Studies; D018450:Disease Progression; D042241:Early Diagnosis; D018728:Entorhinal Cortex / Q000473:pathology*; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D013702:Temporal Lobe / Q000473:pathology*