Regulatory T cells in rheumatoid arthritis.
Regulatory T cells have attracted substantial interest in connection with their role in controlling autoimmunity and the possibility that they could be used therapeutically. Here, we summarize the current understanding of the several subsets of regulatory T cells and defects in their function in rheumatoid arthritis. In evaluating the possibility of using regulatory T cells to treat rheumatoid arthritis, the relationship between these cells and the development and function of Th17 cells must be understood fully.
Sarkar
Sujata
S
Fox
David A
DA
D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D015551:Autoimmunity / Q000502:physiology*; D051858:Forkhead Transcription Factors / Q000378:metabolism; D006801:Humans; D020381:Interleukin-17 / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000502:physiology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism / Q000473:pathology
C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D020381:Interleukin-17