title: Relationship between susceptibility of Candida spp. isolates to amphotericin B and death or survival of patients with candidemia episodes.
abstract: In this study, the susceptibility to amphotericin B of Candida spp. isolates obtained from patients with candidemia was related to their respective clinical outcomes. The susceptibility tests were carried out in three culture media: RPMI 1640, Antibiotic medium 3 and Yeast Nitrogen Base dextrose. We have found that minimal inhibitory concentrations and minimal fungicidal concentrations obtained using AM3 and YNBd media were significantly higher for Candida spp. from patients who died than for those from patients who survived the candidemia (P < 0.05). The assays with RPMI 1640 medium did not show these differences.
authors.affiliation: Department of Microbiology and Parasitology, Universidade Federal de Santa Maria, Rua dos Andradas 1985/201, Santa Maria, RS, Brazil. hartzsa@smail.ufsm.br
authors.forename: Sydney Hartz
authors.initials: SH
authors.lastname: Alves
authors.forename: Everton
authors.initials: E
authors.lastname: Boff
authors.forename: Patricia
authors.initials: P
authors.lastname: Pozzatti
authors.forename: Liliane A
authors.initials: LA
authors.lastname: Scheid
authors.forename: Erico
authors.initials: E
authors.lastname: de Loreto
authors.forename: Loiva T
authors.initials: LT
authors.lastname: Ottoneli Oliveira
authors.forename: Valério
authors.initials: V
authors.lastname: Aquino
authors.forename: Luiz Carlos
authors.initials: LC
authors.lastname: Severo
authors.forename: Janio Morais
authors.initials: JM
authors.lastname: Santurio
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology* / Q000627:therapeutic use; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002175:Candida / Q000187:drug effects*; D002177:Candidiasis / Q000382:microbiology / Q000401:mortality / Q000628:therapy; D003470:Culture Media; D025141:Drug Resistance, Fungal; D006801:Humans; D008826:Microbial Sensitivity Tests; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D003470:Culture Media; D000666:Amphotericin B