title: Enantioselective organocatalyzed Henry reaction with fluoromethyl ketones.
abstract: Remarkable generality in scope of new C9-benzoylcupreines bearing electron-withdrawing substituents for the nitroaldol condensation with fluoromethyl ketones is presented. Both tri- and difluoromethyl ketones provided excellent levels of stereoinduction (ee 76-99%) under mild reaction conditions and low loading of catalyst (1-5 mol%).
authors.affiliation: Dipartimento di Chimica G. Ciamician, Università di Bologna, Via Selmi 2, 40126, Bologna, Italy. marco.bandini@unibo.it
authors.forename: Marco
authors.initials: M
authors.lastname: Bandini
authors.forename: Riccardo
authors.initials: R
authors.lastname: Sinisi
authors.forename: Achille
authors.initials: A
authors.lastname: Umani-Ronchi
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D009574:Nitro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D007659:Ketones; D009574:Nitro Compounds