Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide.
A potent dictyostatin-discodermolide hybrid was designed and synthesised; it showed enhanced cell growth inhibitory activity relative to discodermolide in four human cancer cell lines including the Taxol-resistant NCI/ADR-Res cell line.
Paterson
Ian
I
University Chemical Laboratory, Lensfield Road, Cambridge, UKCB2 1EW. ip100@cam.ac.uk
Naylor
Guy J
GJ
Wright
Amy E
AE
D000473:Alkanes / Q000138:chemical synthesis* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001688:Biological Products / Q000138:chemical synthesis* / Q000494:pharmacology*; D002219:Carbamates / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D015195:Drug Design; D019008:Drug Resistance, Neoplasm; D006801:Humans; D007783:Lactones / Q000138:chemical synthesis* / Q000494:pharmacology*; D018942:Macrolides / Q000138:chemical synthesis* / Q000494:pharmacology*; D017239:Paclitaxel / Q000494:pharmacology; D011753:Pyrones / Q000138:chemical synthesis* / Q000494:pharmacology*
D000473:Alkanes; D000970:Antineoplastic Agents; D001688:Biological Products; D002219:Carbamates; D007783:Lactones; D018942:Macrolides; D011753:Pyrones; C470814:dictyostatin; C071229:discodermolide; D017239:Paclitaxel