Recognition without awareness in a patient with simultanagnosia.
We report a psychophysiological study of "recognition without awareness" in patient 2354, who had severe but circumscribed atrophy in the occipitoparietal region bilaterally (caused by visual-variant Alzheimer's disease, documented by structural and functional neuroimaging) and an accompanying Balint syndrome that prevented her from recognizing the emotional valence of many highly charged negative visual scenes (e.g., a burned body). Despite this lack of overt recognition, patient 2354 nonetheless generated large amplitude skin conductance responses to highly charged negative pictures, demonstrating the same kind of recognition without awareness that has been reported previously in patients with bilateral occipitotemporal dysfunction and prosopagnosia [e.g., Tranel, D., & Damasio, A. R. (1985). Knowledge without awareness: an autonomic index of facial recognition by prosopagnosics. Science, 228, 1453-1454.]. Our case complements both previous evidence of covert, nonconscious recognition in patients with prosopagnosia, and previous behavioral studies of patients with Balint syndrome that have shown evidence of "preattentive" visual processing. The findings add to the small but important set of empirical observations regarding nonconscious visual processing in neurological patients, and indicate that recognition without awareness can occur in the setting of dorsal visual stream dysfunction and Balint syndrome. The findings in our patient suggest that she has patent pathways from higher-order visual cortices to autonomic effectors in the amygdala or hypothalamus, even though the results of such information processing are not made available to conscious awareness.
Denburg
Natalie L
NL
Department of Neurology, Division of Behavioral Neurology and Cognitive Neuroscience, University of Iowa Roy J. and Lucille A. Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242-1053, USA. natalie-denburg@uiowa.edu
Jones
Robert D
RD
Tranel
Daniel
D
D000704:Analysis of Variance; D001364:Awareness; D004644:Emotions; D005260:Female; D019788:Fluorodeoxyglucose F18; D005712:Galvanic Skin Response / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged; D009483:Neuropsychological Tests; D010364:Pattern Recognition, Visual / Q000502:physiology*; D010775:Photic Stimulation; D049268:Positron-Emission Tomography / Q000379:methods; D020238:Prosopagnosia / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D021641:Recognition, Psychology / Q000502:physiology*; D014785:Vision, Ocular / Q000502:physiology
D019788:Fluorodeoxyglucose F18