Regio- and chemoselective magnesiation of protected uracils and thiouracils using TMPMgCl x LiCl and TMP(2)Mg x 2 LiCl.
Two successive regio- and chemoselective magnesiations using TMPMgCl x LiCl and TMP(2)Mg x 2 LiCl enable the full functionalization of protected uracils and thiouracils in good to excellent yields.
Mosrin
Marc
M
Department Chemie, Ludwig-Maximilians-Universität München, Butenandstr. 5-13, Haus F, 81377, München, Germany.
Boudet
Nadège
N
Knochel
Paul
P
D008274:Magnesium / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013889:Thiouracil / Q000737:chemistry*; D014498:Uracil / Q000737:chemistry*
D009942:Organometallic Compounds; D013438:Sulfhydryl Compounds; D014498:Uracil; D013889:Thiouracil; D008274:Magnesium