In vitro and in vivo evaluation of microparticulate drug delivery systems composed of macromolecular prodrugs.
Macromolecular prodrugs are very useful systems for achieving controlled drug release and drug targeting. In particular, various macromolecule-antitumor drug conjugates enhance the effectiveness and improve the toxic side effects. Also, polymeric micro- and nanoparticles have been actively examined and their in vivo behaviors elucidated, and it has been realized that their particle characteristics are very useful to control drug behavior. Recently, researches based on the combination of the concepts of macromolecular prodrugs and micro- or nanoparticles have been reported, although they are limited. Macromolecular prodrugs enable drugs to be released at a certain controlled release rate based on the features of the macromolecule-drug linkage. Micro- and nanoparticles can control in vivo behavior based on their size, surface charge and surface structure. These merits are expected for systems produced by the combination of each concept. In this review, several micro- or nanoparticles composed of macromolecule-drug conjugates are described for their preparation, in vitro properties and/or in vivo behavior.
Onishi
Hiraku
H
Department of Drug Delivery Research, Hoshi University, 2-4-41, Ebara, Shinagawa-ku, Tokyo 142-8501, Japan. onishi@hoshi.ac.jp
Machida
Yoshiharu
Y
D000818:Animals; D003692:Delayed-Action Preparations; D003911:Dextrans / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D041981:Gastrointestinal Tract / Q000378:metabolism; D016685:Mitomycin / Q000737:chemistry; D008954:Models, Biological; D015394:Molecular Structure; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry; D011355:Prodrugs / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics
D003692:Delayed-Action Preparations; D003911:Dextrans; D011355:Prodrugs; D016685:Mitomycin