[Salmonella typhi--time to change empiric treatment].
In the present case series report we describe seven recent cases of typhoid fever. All the patients were travellers returning from Pakistan, where typhoid is endemic. Salmonella typhi isolated from the patients by blood culture were reported as intermediary susceptible to fluoroquinolones in six out of seven cases. We recommend that empiric treatment of suspected cases of typhoid fever includes a third generation cephalosporin such as ceftriaxon. Furthermore, the present report stresses the importance of typhoid vaccination of travellers to areas where typhoid is endemic.
Gade
Christina
C
Infektionsmedicinsk Afdeling, Hvidovre Hospital, DK-2650 Hvidovre. cgade77@hotmail.com
Engberg
Jørgen
J
Weis
Nina
N
D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002443:Ceftriaxone / Q000627:therapeutic use; D003718:Denmark; D005260:Female; D024841:Fluoroquinolones / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010154:Pakistan / Q000208:ethnology; D012485:Salmonella typhi / Q000187:drug effects / Q000302:isolation & purification; D014195:Travel; D014435:Typhoid Fever / Q000188:drug therapy* / Q000517:prevention & control; D014436:Typhoid-Paratyphoid Vaccines / Q000008:administration & dosage
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D014436:Typhoid-Paratyphoid Vaccines; D002443:Ceftriaxone