The telosome/shelterin complex and its functions.
The telomeres that cap the ends of eukaryotic chromosomes serve a dual role in protecting the chromosome ends and in intracellular signaling for regulating cell proliferation. A complex of six telomere-associated proteins has been identified--the telosome or shelterin complex--that is crucial for both the maintenance of telomere structure and its signaling functions.
Xin
Huawei
H
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Baylor Plaza, Houston, TX 77030, USA.
Liu
Dan
D
Songyang
Zhou
Z
D000818:Animals; D005057:Eukaryotic Cells / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D025941:Protein Interaction Mapping; D016615:Telomere / Q000737:chemistry / Q000378:metabolism*; D034501:Telomere-Binding Proteins / Q000737:chemistry / Q000378:metabolism*
D034501:Telomere-Binding Proteins