title: Low human paraoxonase predicts cardiovascular events in Japanese patients with type 2 diabetes.
abstract: Human serum paraoxonase (PON1) is associated with HDL and inhibits oxidative modification of LDL. PON1 enzymatic activity has been shown to decrease in diabetic patients; however, the effect of PON1 status on long-term outcome has not been reported. In this study, we examined the association between baseline PON1 status and the development of cardiovascular disease (CVD) during 10 years of follow-up in 88 type 2 diabetic patients whose enzymatic activities, concentrations, and genetic polymorphisms of PON1 had been determined. A total of 20 CVD events were recorded during the follow-up period. Using Kaplan-Meier survival curves, we found a significantly increased incidence of CVD in patients with a lower concentration or paraoxonase activity of PON1 than each median value (log-rank 7.460; P < 0.01, and log-rank 4.187; P < 0.05, respectively). By Cox regression analysis, both concentration and paraoxonase activity were significantly associated with the development of CVD, even after correction for gender, age, and preexisting CVD (P < 0.05). Low concentration and enzymatic activity of PON1 may be an independent predictor of cardiovascular events in diabetic patients.
authors.affiliation: Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan. ikeday@kochi-u.ac.jp
authors.forename: Yukio
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Mari
authors.initials: M
authors.lastname: Inoue
authors.forename: Tadashi
authors.initials: T
authors.lastname: Suehiro
authors.forename: Kaoru
authors.initials: K
authors.lastname: Arii
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Kumon
authors.forename: Kozo
authors.initials: K
authors.lastname: Hashimoto
mesh_terms: D000328:Adult; D000368:Aged; D043303:Aryldialkylphosphatase / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology / Q000453:epidemiology*; D005260:Female; D005544:Forecasting; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human