title: Thrombotic thrombocytopenic purpura in a patient with very early pregnancy: clinical presentation and autopsy findings.
abstract: Thrombotic thrombocytopenic purpura is a thrombotic microangiopathy leading to microvascular occlusion resulting in ischemic dysfunction of various organs. Pregnancy has been thought to precipitate it during second and third trimester, but its reports in first trimester are extremely rare. We report the clinical protocol of a young lady with 5-week period of gestation, who presented with fever, seizures and altered sensorium, and succumbed to her illness during an episode of seizure. Complete autopsy findings are also presented in detail.
authors.affiliation: Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India. amansharma74@yahoo.com
authors.forename: Aman
authors.initials: A
authors.lastname: Sharma
authors.forename: Bishan
authors.initials: B
authors.lastname: Radotra
authors.forename: Ajay
authors.initials: A
authors.lastname: Wanchu
authors.forename: Pankaj
authors.initials: P
authors.lastname: Malhotra
authors.forename: Surjit
authors.initials: S
authors.lastname: Singh
authors.forename: Subhash
authors.initials: S
authors.lastname: Varma
mesh_terms: D000328:Adult; D001344:Autopsy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000473:pathology*; D011697:Purpura, Thrombotic Thrombocytopenic / Q000473:pathology*