Rationale for reading fluconazole MICs at 24 hours rather than 48 hours when testing Candida spp. by the CLSI M27-A2 standard method.
We investigated if CLSI M27-A2 Candida species breakpoints for fluconazole MIC are valid when read at 24 h. Analysis of a data set showed good correlation between 48- and 24-h MICs, as well as similar outcomes and pharmacodynamic efficacy parameters, except for isolates in the susceptible dose-dependent category, such as Candida glabrata.
Ostrosky-Zeichner
Luis
L
University of Texas Medical School at Houston, Texas 77030, USA. Luis.Ostrosky-Zeichner@uth.tmc.edu
Rex
John H
JH
Pfaller
Michael A
MA
Diekema
Daniel J
DJ
Alexander
Barbara D
BD
Andes
David
D
Brown
Steven D
SD
Chaturvedi
Vishnu
V
Ghannoum
Mahmoud A
MA
Knapp
Cindy C
CC
Sheehan
Daniel J
DJ
Walsh
Thomas J
TJ
D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects* / Q000302:isolation & purification; D002177:Candidiasis / Q000188:drug therapy / Q000382:microbiology; D016208:Databases, Factual; D015725:Fluconazole / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods / Q000592:standards* / Q000706:statistics & numerical data; D008954:Models, Biological; D013997:Time Factors
D000935:Antifungal Agents; D015725:Fluconazole