The use of monoclonal antibodies to Neisseria lactamica in an antigen selection to Neisseria meningitides B vaccine.
Abstract Neisseria lactamica, a commensal bacterium that is non-pathogenic to humans and is usually found in the upper respiratory tract of children, is closely related to the pathogenic species Neisseria meningitidis. Colonization by Neisseria lactamica can be responsible for the development of natural immunity to meningococcal infection in childhood, when rates of meningococcal carriers are low. These features suggest that N. lactamica components can be key elements in the production of a new vaccine for N. meningitidis. The production of monoclonal antibodies for N. lactamica is an important tool in the selection of new antigens for the preparation of a vaccine for N. meningitidis B.
De Gaspari
Elizabeth N
EN
Adolfo Lutz Institute, São Paulo, Brazil. egaspari@ial.sp.gov.br
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D006801:Humans; D051379:Mice; D042806:Neisseria lactamica / Q000276:immunology*; D009345:Neisseria meningitidis / Q000276:immunology*; D014612:Vaccines / Q000276:immunology*
D000911:Antibodies, Monoclonal; D014612:Vaccines