title: Lipooxygenase inhibition in osteoarthritis: a potential symptomatic and disease modifying effect?
abstract: 5-Loxin is a compound extracted from an ancient herb that might be considered as a potent lipooxygenase inhibitor. The results observed in a preliminary trial suggest a highly intriguing clinically relevant symptomatic effect contrasting with a poor bioavailability of this compound. Moreover, in this trial, a statistically significant decrease in matrix metalloproteinase enzyme serum level suggests that, in addition to the observed symptomatic effect, such a compound might have a disease modifying effect in osteoarthritis. Further studies are required both to confirm the symptomatic efficacy and acceptable safety profile and to evaluate the potential chondromodulating effect of this compound.
authors.forename: Maxime
authors.initials: M
authors.lastname: Dougados
mesh_terms: D006801:Humans; D016859:Lipoxygenase Inhibitors / Q000627:therapeutic use*; D010003:Osteoarthritis / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic
chemical_list: D016859:Lipoxygenase Inhibitors