Selective synthesis of double temperature-sensitive polymer-peptide conjugates.
A novel synthetic route has been developed to couple selectively a modified octa-peptide, that is able to gel at low temperature, to the prototypical thermoresponsive polymer poly(N-isopropylacrylamide) to give a bioconjugate that exhibits double thermoresponsiveness.
Stoica
Florentina
F
School of Chemical Engineering and Analytical Science, University of Manchester, Manchester, UK M60 1QD.
Alexander
Cameron
C
Tirelli
Nicola
N
Miller
Aline F
AF
Saiani
Alberto
A
D000178:Acrylamides / Q000737:chemistry*; D000180:Acrylic Resins; D002152:Calorimetry, Differential Scanning; D010455:Peptides / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D013696:Temperature
D000178:Acrylamides; D000180:Acrylic Resins; D010455:Peptides; D011108:Polymers; C052970:poly-N-isopropylacrylamide