title: Ni(II), Cu(II), and Zn(II) diethyldithiocarbamate complexes show various activities against the proteasome in breast cancer cells.
abstract: A series of three complexes with diethyldithiocarbamate ligand and three different metals (Ni, Cu, Zn) was prepared, confirmed by X-ray crystallography, and tested in human breast cancer MDA-MB-231 cells. Zinc and copper complexes, but not nickel complex, were found to be more active against cellular 26S proteasome than against purified 20S proteasome core particle. One of the possible explanations is inhibition of JAMM domain in the 19S proteasome lid.
authors.affiliation: Department of Medical Chemistry and Biochemistry, Department of Cell Biology and Genetics, Palacky University, Olomouc 77515, Czech Republic.
authors.forename: Boris
authors.initials: B
authors.lastname: Cvek
authors.forename: Vesna
authors.initials: V
authors.lastname: Milacic
authors.forename: Jan
authors.initials: J
authors.lastname: Taraba
authors.forename: Q Ping
authors.initials: QP
authors.lastname: Dou
mesh_terms: D001943:Breast Neoplasms / Q000201:enzymology* / Q000473:pathology; D045744:Cell Line, Tumor; D003300:Copper; D004050:Ditiocarb / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D009532:Nickel; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D061988:Proteasome Inhibitors; D015032:Zinc
chemical_list: D004791:Enzyme Inhibitors; D009942:Organometallic Compounds; D061988:Proteasome Inhibitors; C067982:bis(N,N-diethyldithiocarbamate)Cu (II) complex; D003300:Copper; D009532:Nickel; D004050:Ditiocarb; D046988:Proteasome Endopeptidase Complex; D015032:Zinc