title: [Inhibition of bacterial adhesion and prevention of biofilm formation: Use of organic self-assembled monolayers on inorganic surfaces].
abstract: Implant related nosocomial infections are a serious public health concern. Colonisation by contaminating bacteria of the bare implant surface may lead to the formation of a biofilm protecting bacteria against host defences and antibiotics. To decrease the risk of infection, a strategy is to modify the biomaterial surface by an antibacterial coating, inhibiting bacterial adhesion ("passive" coatings) or able to kill bacteria ("active" coatings). This article describes the potential of self-assembled monolayers as antibacterial coatings allowing the molecular level control of the surface properties of inorganic substrates. After a presentation of the compounds used to form self-assembled monolayers, we present the literature dealing with antibacterial monolayers and the latest developments concerning "active" phosphonate monolayers that significantly inhibit the growth of bacterial biofilm.
authors.affiliation: UMR 5253, CC 1701, université Montpellier-2, institut Charles-Gerhardt-Montpellier, place Eugène-Bataillon, 34095 Montpellier cedex, France. guerrero@univ-montp2.fr
authors.forename: G
authors.initials: G
authors.lastname: Guerrero
authors.forename: J
authors.initials: J
authors.lastname: Amalric
authors.forename: P-H
authors.initials: PH
authors.lastname: Mutin
authors.forename: A
authors.initials: A
authors.lastname: Sotto
authors.forename: J-P
authors.initials: JP
authors.lastname: Lavigne
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001422:Bacterial Adhesion / Q000187:drug effects*; D018441:Biofilms; D002264:Carboxylic Acids / Q000494:pharmacology; D020099:Coated Materials, Biocompatible; D004220:Disulfides / Q000494:pharmacology; D004341:Drug Evaluation; D006801:Humans; D007287:Inorganic Chemicals / Q000737:chemistry*; D015394:Molecular Structure; D009930:Organic Chemicals / Q000737:chemistry / Q000494:pharmacology*; D063065:Organophosphonates / Q000494:pharmacology; D009943:Organophosphorus Compounds / Q000494:pharmacology; D016459:Prosthesis-Related Infections / Q000517:prevention & control; D013438:Sulfhydryl Compounds / Q000494:pharmacology; D013499:Surface Properties / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D002264:Carboxylic Acids; D020099:Coated Materials, Biocompatible; D004220:Disulfides; D007287:Inorganic Chemicals; D009930:Organic Chemicals; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D013438:Sulfhydryl Compounds