Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro.
In this study 10 guaianolide-type sesquiterpene gamma-lactones named amphoricarpolides, isolated from the aerial parts of two endemic subspecies of Amphoricarpos neumayeri (ssp. neumayeri and ssp. murbeckii Bosnjak), were investigated by means of reversed-phase thin-layer chromatography. Methanol-water and tetrahydrofuran-water binary mixtures were used as mobile phase in order to determine lipophilicity parameters R (0) (M) and C(0). Some of the investigated compounds were screened for their cytotoxic activity against HeLa and B16 cells. Chromatographically obtained lipophilicity parameters were correlated with calculated logP values and IC(50) values. Principal component analysis identified the dominant pattern in the chromatographically obtained data.
Atrrog
Abubaker A B
AA
University of Belgrade, Serbia.
Natić
Maja
M
Tosti
Tomislav
T
Milojković-Opsenica
Dusanka
D
Dordević
Iris
I
Tesević
Vele
V
Jadranin
Milka
M
Milosavljević
Slobodan
S
Lazić
Milan
M
Radulović
Sinisa
S
Tesić
Zivoslav
Z
D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D002855:Chromatography, Thin Layer; D003198:Computer Simulation; D006367:HeLa Cells; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*; D051379:Mice; D008956:Models, Chemical; D054548:Montenegro; D010936:Plant Extracts / Q000737:chemistry*; D025341:Principal Component Analysis; D012044:Regression Analysis; D045789:Sesquiterpenes, Guaiane / Q000737:chemistry*; D013329:Structure-Activity Relationship
D007783:Lactones; D008055:Lipids; D010936:Plant Extracts; D045789:Sesquiterpenes, Guaiane