Experimental models and mechanisms underlying the protective effects of n-3 polyunsaturated fatty acids in Alzheimer's disease.
Dementia such as Alzheimer's disease (AD) is a growing health problem in aging populations in many countries around the world. Currently, there is no cure for AD; consequently, alternative therapies are urgently needed. Recent studies suggest that nutritional intervention may have therapeutic benefits for AD. Specifically, an increased intake of n-3 polyunsaturated fatty acids (PUFA) from fish and marine oils may lower AD risk. This review will summarize the current body of knowledge regarding the association between n-3 PUFA and AD, including human studies and experimental models, and potential mechanisms of action.
Boudrault
Cynthia
C
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada M5S 3E2.
Bazinet
Richard P
RP
Ma
David W L
DW
D000375:Aging; D000544:Alzheimer Disease / Q000453:epidemiology / Q000378:metabolism* / Q000628:therapy; D000818:Animals; D001921:Brain / Q000378:metabolism; D002478:Cells, Cultured; D004032:Diet; D004195:Disease Models, Animal; D015525:Fatty Acids, Omega-3 / Q000378:metabolism*; D005395:Fish Oils; D006801:Humans; D021962:Membrane Microdomains / Q000737:chemistry; D051379:Mice; D051381:Rats; D012306:Risk
D015525:Fatty Acids, Omega-3; D005395:Fish Oils