Chronic granulomatous disease as a risk factor for autoimmune disease.
Chronic granulomatous disease (CGD) is characterized by recurrent infections and granuloma formation. In addition, we have observed a number of diverse autoimmune conditions in our CGD population, suggesting that patients with CGD are at an elevated risk for development of autoimmune disorders. In this report, we describe antiphospholipid syndrome, recurrent pericardial effusion, juvenile idiopathic arthritis, IgA nephropathy, cutaneous lupus erythematosus, and autoimmune pulmonary disease in the setting of CGD. The presence and type of autoimmune disease have important treatment implications for patients with CGD.
De Ravin
Suk See
SS
National Institutes of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892-1456, USA. sderavin@niaid.nih.gov
Naumann
Nora
N
Cowen
Edward W
EW
Friend
Julia
J
Hilligoss
Dianne
D
Marquesen
Martha
M
Balow
James E
JE
Barron
Karyl S
KS
Turner
Maria L
ML
Gallin
John I
JI
Malech
Harry L
HL
D000293:Adolescent; D000328:Adult; D001327:Autoimmune Diseases / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000150:complications* / Q000473:pathology / Q000628:therapy; D006801:Humans; D008171:Lung Diseases / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D008297:Male; D010490:Pericardial Effusion / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D012307:Risk Factors