title: [Intravenous thrombolysis in pediatric arterial ischemic stroke: a case report and a review of the literature].
abstract: Pediatric arterial ischemic stroke (AIS) is little known by pediatricians, as it is rare and difficult to diagnose. Current therapeutic approaches include platelet aggregation inhibitors, anticoagulation using heparin or thrombolysis with rt-PA, and therapeutic abstention in the absence of consensus, in contrast with stroke in adults. We report the case of a 3-year-old child who benefited from intravenous thrombolysis with rt-PA 2h after a major AIS of the anterior and middle left arteries due to embolism from the heart. Neurological progression was marked by a persistent, severe functional deficiency, in spite of the early use of thrombolysis. No hemorrhagic complication occurred. This observation raises the problem of therapeutic indications in childhood AIS and more particularly the question of the use of intravenous thrombolysis. Currently, few studies exist on this subject and only a few case report of children and teenagers having received effective intravenous or intra-arterial thrombolysis further to an AIS are available in the literature. A single study describes 46 cases of children with AIS having received thrombolysis but reports numerous complications. However, the absence of symptomatic hemorrhagic complications is noteworthy. There is currently insufficient evidence to recommend thrombolysis in pediatric AIS; nevertheless it can be proposed in certain rare cases, similar to the observation reported herein.
authors.affiliation: Service de cardiologie pédiatrique, hôpital cardiologique Louis-Pradel, 28, avenue du Doyen-Jean-Lépine, 69500 Bron, France. hbourdial@yahoo.fr
authors.forename: H
authors.initials: H
authors.lastname: Bourdial
authors.forename: F
authors.initials: F
authors.lastname: Sassolas
authors.forename: D
authors.initials: D
authors.lastname: Ville
authors.forename: S
authors.initials: S
authors.lastname: Di Filippo
mesh_terms: D002545:Brain Ischemia / Q000188:drug therapy*; D002675:Child, Preschool; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D020521:Stroke / Q000188:drug therapy*; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator