[Neurochemical mechanisms of food aversion conditioning consolidation in snail helix lucorum].
Effects of cycloheximide, protein synthesis inhibitor as well as serotonin receptor antagonist and NMDA receptor antagonist, on food aversion conditioning consolidation were studied in snail Helix lucorum. Food aversion conditioning was absent in snails after application of cycloheximide. Repeated training produced no food aversion conditioning for the same type of food in these snails without cycloheximide application. Food aversion conditioning was absent in snails after metiotepin, nonselective serotonin receptors antagonist, or after MK-801, NMDA glutamate receptors antagonist, applications. At the same time, repeated training produced facilitated food aversion conditioning for the same type of food in these snails. Our experiments were the first which showed that effect on different molecular mechanisms evoked reversible or irreversible disruption of long-term memory consolidation during the same learning. It was suggested that suppression of retrieval produced reversible effect whereas disruption of memory storage initiated irreversible effect on long-term memory consolidation.
Solntseva
S V
SV
Nikitin
V P
VP
D000818:Animals; D003513:Cycloheximide / Q000494:pharmacology; D016291:Dizocilpine Maleate / Q000494:pharmacology; D005502:Food; D006372:Helix, Snails; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D018696:Neuroprotective Agents / Q000494:pharmacology; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000494:pharmacology
D018696:Neuroprotective Agents; D011500:Protein Synthesis Inhibitors; D016194:Receptors, N-Methyl-D-Aspartate; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D016291:Dizocilpine Maleate; D003513:Cycloheximide