Antigenic mimicry of the HIV envelope by AIDS-associated pathogens.
Only one broadly neutralizing anti-HIV antibody, 2G12, recognises the envelope sugars of HIV. In the present study, we show that 2G12 also recognises Candida albicans and Candida tropicalis with high affinity (11 nmol/l) through a carbohydrate-dependent interaction (50% inhibitory concentration for D-fructose, 12 mmol/l). This is the first report of a neutralizing HIV antibody displaying cross-reactivity with another pathogen, revealing that the carbohydrate neutralization determinant of HIV, defined by 2G12, is more widespread amongst immunogenic, microbial surfaces than previously recognized.
Dunlop
D Cameron
DC
Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford, UK.
Ulrich
Alexander
A
Appelmelk
Ben J
BJ
Burton
Dennis R
DR
Dwek
Raymond A
RA
Zitzmann
Nicole
N
Scanlan
Christopher N
CN
D000911:Antibodies, Monoclonal / Q000276:immunology; D000946:Antigens, Fungal / Q000276:immunology; D000080908:Broadly Neutralizing Antibodies; D002175:Candida / Q000276:immunology*; D003429:Cross Reactions; D015483:HIV Antibodies; D015699:HIV Envelope Protein gp120 / Q000276:immunology*; D006801:Humans; D018716:Molecular Mimicry
C529157:2G12 monoclonal antibody; D000911:Antibodies, Monoclonal; D000946:Antigens, Fungal; D000080908:Broadly Neutralizing Antibodies; D015483:HIV Antibodies; D015699:HIV Envelope Protein gp120