Prognostic value of the PAI-1 4G/5G polymorphism in invasive ductal carcinoma of the breast.
The study group was derived from the archive materials of 55 invasive ductal breast cancer (IDC) patients who had undergone breast-preserving surgery (partial mastectomy/ axillary dissection). All patients included in the study had clinically T(1)-2, N0-M0 invasive ductal carcinoma. Genomic DNA species were extracted from paraffin-embedded blocks, and plasminogen activator inhibitor type-1 (PAI-1) gene 4G/5G genotyping was done by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP). Patient demographics, axillary metastasis status, metastatic lymph nodi/total dissected lymph nodes from axilla, histopathologic characteristics of tumors, local recurrences, and survival ratio were assessed. PAI-1 4G/5G genotype frequencies were 4G/4G (64%), 4G/5G (31%), and 5G/5G (5%) in the patient group. According to the results based on frequencies, the demographics were not different. Five-year local recurrence rate of 4G/5G patients was the lowest (2/17, 12%) (P = 0.02). Also five-year distant metastases ratio of 4G/5G patients was the highest (18%) (P = 0.01). Five- and 10-year disease-free survival rates for the 4G/4G, 4G/5G, and 5G/5G groups were 97% and 94%, 82% and 77%, and 100% and 94%, respectively (P = 0.004). The results of this study indicate that the 4G allele in the PAI 1 gene had a negative impact on local recurrence and disease-free survival of patients with clinical T(1)-2N0M0 IDC.
Yagmurdur
M C
MC
Department of General Surgery, Baskent University Faculty of Medicine, Ankara, Turkey.
Atac
F B
FB
Tutar
N U
NU
Verdi
H
H
Isiklar
I
I
Ozdemir
B H
BH
Ozbek
N
N
Karakayali
H
H
Haberal
M
M
D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics* / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000235:genetics* / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D005838:Genotype; D006801:Humans; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000235:genetics; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D011110:Polymorphism, Genetic; D011379:Prognosis; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D014421:Turkey
D017395:Plasminogen Activator Inhibitor 1