Lung dendritic cells: targets for therapy in allergic disease.
Dendritic cells (DCs) are crucial in determining the functional outcome of allergen encounter in the lung. Antigen presentation by myeloid DCs leads to Th2 sensitization typical of allergic disease, whereas antigen presentation by plasmacytoid DCs serves to dampen inflammation. It is increasingly clear that DCs have an antigen presenting function beyond sensitization. DCs therefore constitute a novel target for the development of antiallergic therapy aimed at the origin of the inflammatory cascade. A careful study of DC biology and of the receptors expressed by lung DCs has provided a framework for the discovery of novel antiallergic compounds.
Lambrecht
B
B
Department of Respiratory Diseases, University Hospital Ghent, Ghent, Belgium, and Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands.
Hammad
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H
D000818:Animals; D017951:Antigen Presentation; D002454:Cell Differentiation; D050677:Core Binding Factor Alpha 3 Subunit / Q000276:immunology; D016207:Cytokines / Q000276:immunology / Q000378:metabolism*; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D005786:Gene Expression Regulation; D006801:Humans; D007108:Immune Tolerance; D008168:Lung / Q000276:immunology / Q000473:pathology; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D012130:Respiratory Hypersensitivity / Q000235:genetics / Q000276:immunology* / Q000378:metabolism* / Q000628:therapy; D015398:Signal Transduction; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000378:metabolism*; D000094632:Thymic Stromal Lymphopoietin
D050677:Core Binding Factor Alpha 3 Subunit; D016207:Cytokines; D008565:Membrane Proteins; C493730:Runx3 protein, mouse; D016212:Transforming Growth Factor beta; C084881:flt3 ligand protein; D000094632:Thymic Stromal Lymphopoietin