High temperature metalation of functionalized aromatics and heteroaromatics using (tmp)2Zn x 2 MgCl2 x 2 LiCl and microwave irradiation.
A wide range of polyfunctional aryl and heteroaryl zinc reagents were efficiently prepared in THF via direct zincation using (tmp)2Zn x 2 MgCl2 x 2 LiCl and microwave irradiation. Ester and cyano functions as well as ketones are compatible with the high temperatures of the zincation. The resulting bis-organo zinc species undergo a number of subsequent reactions leading to highly functionalized aromatics and heteroaromatics in good to excellent yields.
Wunderlich
Stefan
S
Department Chemie and Biochemie, Ludwig-Maximilians-Universität, 81377 Munich, Germany.
Knochel
Paul
P
D006358:Hot Temperature; D008670:Metals / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*
D008670:Metals; D009942:Organometallic Compounds