title: Microgravity and the implications for wound healing.
abstract: Wound healing is a sophisticated response ubiquitous to various traumatic stimuli leading to an anatomical/functional disruption. The aim of present article was to review the current evidence regarding the effects of microgravity on wound healing dynamics. Modulation of haemostatic phase because of alteration of platelet quantity and function seems probable. Furthermore, production of growth factors that are released from activated platelets and infiltration/function of inflammatory cells seem to be impaired by microgravity. Proliferation of damaged structures is dependent on orchestrated function of various growth factors, for example transforming growth factors, platelet-derived growth factor and epidermal growth factor, all of which are affected by microgravitational status. Moreover, gravity-induced alterations of gap junction, neural inputs, and cell populations have been reported. It may be concluded that different cellular and extracellular element involved in the healing response are modified through effect of microgravity which may lead to impairment in healing dynamics.
authors.affiliation: Department of Oral Biology, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran. r.mostofi@gmail.com
authors.forename: Ramin Mostofizadeh
authors.initials: RM
authors.lastname: Farahani
authors.forename: Luisa A
authors.initials: LA
authors.lastname: DiPietro
mesh_terms: D004815:Epidermal Growth Factor / Q000502:physiology; D055317:Evidence-Based Practice; D006097:Granulation Tissue / Q000502:physiology; D006487:Hemostasis / Q000502:physiology; D006801:Humans; D007249:Inflammation; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D015539:Platelet Activation / Q000502:physiology; D010982:Platelet-Derived Growth Factor / Q000502:physiology; D014893:Weightlessness; D014945:Wound Healing / Q000502:physiology*
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D010982:Platelet-Derived Growth Factor; D004815:Epidermal Growth Factor