[The relationship between SNP of cholecystokinin gene and certain mental status and its forensic significance].
Cholecystokinin (CCK) is a brain-gut peptide with broad biological activities. It is one of the main regulating hormones in the digestive system, and it plays an important physiological role in the central and peripheral nervous system as a neurotransmitter or a neuromodulator. Recently, many reports have demonstrated that there were a number of SNPs on CCK gene, of which -45C/T and -196G/A showed certain correlation with a variety of psychiatric states such as schizophrenia, depressive disorder, suicidal behavior, Parkinson's disease, etc. These SNPs may be used in paternity testing and personal identification. In addition, it may also become one of the auxiliary indicators in some special cases of forensic pathology.
Yang
Jun
J
School of Forensic Medicine, China Medical University, Shenyang 110001, China. yangliu03170015@163.com
Wang
Bao-jie
BJ
Ding
Mei
M
Pang
Hao
H
Sun
Xue-fei
XF
Li
Zhong-jie
ZJ
D002766:Cholecystokinin / Q000235:genetics*; D005554:Forensic Medicine; D006801:Humans; D001523:Mental Disorders / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011569:Psychiatric Status Rating Scales
D002766:Cholecystokinin