title: Central and pericentral retinal sensitivity after macular translocation surgery.
abstract: OBJECTIVE
  To evaluate the separate contribution of the retina versus retinal pigment epithelium (RPE)-choriocapillaris to visual function after treatment of neovascular age-related macular degeneration by measuring retinal sensitivity across three areas after macular translocation surgery.
  
  
  METHODS
  Using the Nidek microperimeter-1, we tested retinal sensitivity across three areas in 35 patients after macular translocation surgery. Microperimetry scores ranged from -2 (no response to brightest stimulus) to 20 (response with 20 dB neutral density filtering). Median retinal sensitivity score (MRSS) for the central 10-degrees (Area 1, fovea translocated over healthier RPE) was compared with acuity, reading speed and MRSS of adjacent areas: Area 2, retina over site of choroidal neovascularization removal and Area 3, retina over undisturbed RPE.
  
  
  RESULTS
  In 27 of 35 eyes in this study (77%), the MRSS for Area 1, was greater than Area 2. Area 1 was a median of 3.0 decibels (dB) greater in sensitivity (range, 16 greater-2 lower) than Area 2 (P < or = 0.001), and 5.0 dB lower (range, 2 greater-12 lower) than Area 3 (P < or = 0.001). The median of the MRSS (25th/75th percentile) for Areas 1, 2 and 3 were 2.0 (0.0/6.0), -2.0 (-2.0/-2.0) and 9 (4.0/12.0), respectively. The MRSS for Area 1 correlated with reading speed more than with acuity.
  
  
  CONCLUSIONS
  Sensitivity of the translocated macula was significantly greater than in Area 2, retina over abnormal RPE-choriocapillaris, suggesting that disturbed RPE-choriocapillaris significantly limits retinal function. Area 1 sensitivity was lower than in retina unaffected by age-related macular degeneration over undisturbed RPE, suggesting that persisting retinal dysfunction can limit vision recovery.
authors.affiliation: Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA.
authors.forename: Janet J
authors.initials: JJ
authors.lastname: Chieh
authors.forename: Sandra S
authors.initials: SS
authors.lastname: Stinnett
authors.forename: Cynthia A
authors.initials: CA
authors.lastname: Toth
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020256:Choroidal Neovascularization / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005403:Fixation, Ocular / Q000502:physiology; D005451:Fluorescein Angiography; D005466:Fluorocarbons / Q000008:administration & dosage; D006801:Humans; D008268:Macular Degeneration / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D011446:Prospective Studies; D012160:Retina / Q000503:physiopathology* / Q000637:transplantation*; D055213:Retinal Pigment Epithelium / Q000503:physiopathology; D012684:Sensory Thresholds / Q000502:physiology; D012827:Silicone Oils / Q000008:administration & dosage; D014792:Visual Acuity / Q000502:physiology; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology; D014821:Vitrectomy
chemical_list: D005466:Fluorocarbons; D012827:Silicone Oils