A new compound from Senecio cannabifolius var integrilifolius.
Senecio cannabifolius var integrilifolius (Compositae), locally known as "Fanhuncao" in China, is a folk herb used for the treatment of pneumonia, virus influenza and bronchitis. To investigate the chemical constituents of this herb, water extract of the aerial parts was subjected to various chromatography on normal/reversed phase silica gel and Sephadex LH-20 column. Eleven compounds were obtained and identified on the basis of their physicochemical properties and spectroscopic analysis as senecine (1), p-hydroxy-benzeneacetic acid (2), protocatechuic acid (3), 2,5-dihydroxy-benzeneacetic acid (4), 3,4-dihydroxy-benzeneacetic acid (5), vanillic acid (6), caffic acid (7), succinic acid (8), 2-furoic acid (9), 1, 2, 4, 5-tetrahydro-jacaranone (10), and 4-(pyrrolidin-2-one)-phenylacetic acid (11). Compound 1 was structurally identified to be a new compound; the other compounds were isolated from this plant for the first time.
Ma
Hong-Yan
HY
Department of Pharmacognosy, China Pharmaceutical University, Nanjing 210038, China.
Yang
Li
L
Zhang
Mian
M
Wang
Chang-Hong
CH
Wang
Zheng-Tao
ZT
D000814:Aniline Compounds / Q000737:chemistry / Q000302:isolation & purification*; D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000302:isolation & purification; D062385:Hydroxybenzoates / Q000737:chemistry / Q000302:isolation & purification; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D012674:Senecio / Q000737:chemistry*; D014641:Vanillic Acid / Q000737:chemistry / Q000302:isolation & purification
D000814:Aniline Compounds; D016588:Anticarcinogenic Agents; D062385:Hydroxybenzoates; C543481:senecine; C009091:protocatechuic acid; D014641:Vanillic Acid