title: Primary hepatic marginal zone B cell lymphoma of mucosa-associated lymphoid tissue type: case report and review of the literature.
abstract: A primary hepatic marginal zone B cell lymphoma of mucosa-associated lymphoid tissue (MALT) is very rare. We found a solitary mass 27 mm in size in the left lobe of the liver of a 58-year-old Japanese man with a history of hepatitis-C infection. Based on the results of imaging studies, the tumor was diagnosed as a hepatocellular carcinoma (HCC). The left lobe of the liver was lobectomized and microscopic findings showed that the tumor was a hepatic MALT lymphoma, while immunohistochemistry showed it to be positive for CD20 and CD79a. In a fluorodeoxyglucose-positron emission tomography examination integrated with computed tomography scanning (FDG-PET CT) before surgery, the tumor was revealed to have a high standardized uptake value (SUV) for FDG. The patient received chemotherapy after surgery. To the best of our knowledge, 45 cases had been reported with a mean age for all patients of 61.4 years. The pathogenesis remains unclear, although half of the patients had a past history of chronic inflammatory liver disease. Surgical resection was performed in most cases and some patients received postoperative chemotherapy or radiotherapy. The clinicopathologic characteristics and management of this extremely rare disease are also discussed.
authors.affiliation: Department of Gastroenterology, Ehime Prefectural Central Hospital, Ehime, 790-0024, Japan. hirokazud@me.pikara.ne.jp.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Doi
authors.affiliation: Department of Gastroenterology, Ehime Prefectural Central Hospital, Ehime, 790-0024, Japan.
authors.forename: Norio
authors.initials: N
authors.lastname: Horiike
authors.affiliation: Department of Gastroenterology, Ehime Prefectural Central Hospital, Ehime, 790-0024, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hiraoka
authors.affiliation: Department of Gastroenterology, Ehime Prefectural Central Hospital, Ehime, 790-0024, Japan.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Koizumi
authors.affiliation: Department of Gastroenterology, Ehime Prefectural Central Hospital, Ehime, 790-0024, Japan.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Yamamoto
authors.affiliation: Department of Gastroenterology, Ehime Prefectural Central Hospital, Ehime, 790-0024, Japan.
authors.forename: Aki
authors.initials: A
authors.lastname: Hasebe
authors.affiliation: Department of Gastroenterology, Ehime Prefectural Central Hospital, Ehime, 790-0024, Japan.
authors.forename: Soichi
authors.initials: S
authors.lastname: Ichikawa
authors.affiliation: Department of Gastroenterology, Ehime Prefectural Central Hospital, Ehime, 790-0024, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Yano
authors.affiliation: Department of Gastroenterology, Ehime Prefectural Central Hospital, Ehime, 790-0024, Japan.
authors.forename: Yasunao
authors.initials: Y
authors.lastname: Miyamoto
authors.affiliation: Department of Gastroenterology, Ehime Prefectural Central Hospital, Ehime, 790-0024, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Ninomiya
authors.affiliation: Department of Radiology, Ehime Prefectural Central Hospital, Ehime, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Ishimaru
authors.affiliation: Department of Radiology, Ehime Prefectural Central Hospital, Ehime, Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Miyagawa
authors.affiliation: Department of Surgery, Ehime Prefectural Central Hospital, Ehime, Japan.
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Takamura
authors.affiliation: Department of Surgery, Ehime Prefectural Central Hospital, Ehime, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Kawasaki
authors.affiliation: Department of Hematology, Ehime Prefectural Central Hospital, Ehime, Japan.
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Kozuka
authors.affiliation: Department of Medical Laboratory, Ehime Prefectural Central Hospital, Ehime, Japan.
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Maeda
authors.affiliation: Department of Pathology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yoshino
mesh_terms: D018951:Antigens, CD20; D044466:Asian People; D051925:CD79 Antigens; D006526:Hepatitis C / Q000473:pathology; D006801:Humans; D007564:Japan; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy*; D018442:Lymphoma, B-Cell, Marginal Zone / Q000378:metabolism / Q000473:pathology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods
chemical_list: D018951:Antigens, CD20; D051925:CD79 Antigens; C497881:CD79A protein, human