Investigation of interaction between DCDC2 and KIAA0319 in a large German dyslexia sample.
The dyslexia susceptibility locus DYX2 (chr. 6p21-p22) harbours two candidate genes, DCDC2 and KIAA0319. In 2006, Harold et al. reported evidence for interaction between both genes. Having previously identified a risk haplotype for dyslexia in DCDC2, but not KIAA0319, in German families, we also tested for interaction between this risk haplotype and KIAA0319. We found a nominally significant association for the quantitative dimension "word reading", the core phenotype in the study of Harold et al., which may be considered as supportive evidence.
Ludwig
Kerstin U
KU
Department of Genomics, Life and Brain Center, University of Bonn, Sigmund-Freud Str. 25, 53105, Bonn, Germany.
Roeske
Darina
D
Schumacher
Johannes
J
Schulte-Körne
Gerd
G
König
Inke R
IR
Warnke
Andreas
A
Plume
Ellen
E
Ziegler
Andreas
A
Remschmidt
Helmut
H
Müller-Myhsok
Bertram
B
Nöthen
Markus M
MM
Hoffmann
Per
P
D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D004410:Dyslexia / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology*; D005858:Germany / Q000453:epidemiology; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008869:Microtubule-Associated Proteins / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D011932:Reading
C510451:DCDC2 protein, human; C500377:KIAA0319 protein, human; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins