title: A systematic review of the use and validation of health-related quality of life instruments in older cancer patients.
abstract: OBJECTIVE
  The aim of this paper is to systematically review the use and validation of HRQOL instruments in older cancer patients.
  
  
  METHODS
  A systematic review of 5 databases and 3 research registers identified studies reporting the use and validation of HRQOL instruments in cancer patients aged over 65 years from 1995 to mid 2007.
  
  
  RESULTS
  Thirty-one studies reported the use of HRQOL measures in older people, using a range of generic and disease-specific instruments. Little work was reported in patients aged over 80 years. All studies exhibited methodological limitations. Fourteen studies were identified with variable evidence on the psychometric properties and clinical usefulness of identified instruments.
  
  
  CONCLUSIONS
  Our review identified that the development, validation and use of HRQOL instruments often ignore the specific needs of older people. This review highlights the need for a HRQOL instrument specifically designed to capture the issues and concerns most relevant to older cancer patients.
authors.affiliation: School of Health Science, Swansea University, Swansea, UK.
authors.forename: Deborah
authors.initials: D
authors.lastname: Fitzsimmons
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Gilbert
authors.forename: Frances
authors.initials: F
authors.lastname: Howse
authors.forename: Teresa
authors.initials: T
authors.lastname: Young
authors.forename: Juan-Ignacio
authors.initials: JI
authors.lastname: Arrarras
authors.forename: Anne
authors.initials: A
authors.lastname: Brédart
authors.forename: Sheila
authors.initials: S
authors.lastname: Hawker
authors.forename: Steve
authors.initials: S
authors.lastname: George
authors.forename: Matti
authors.initials: M
authors.lastname: Aapro
authors.forename: Colin D
authors.initials: CD
authors.lastname: Johnson
mesh_terms: D000368:Aged; D016208:Databases, Factual; D006305:Health Status Indicators; D006801:Humans; D011594:Psychometrics; D011788:Quality of Life; D054928:Validation Studies as Topic