title: [A comparative study of efficacy and safety of torin and zoloft].
abstract: Zoloft (sertraline) is an original antidepressant of "Pfizer", torin is a generic form of sertraline of Veropharm. An aim of the study was to compare clinical effectiveness and tolerability of original and generic drugs. Forty patients with moderate and severe depression without psychotic symptoms have been studied: 20 of them were treated with torin and 20 with zoloft. Patient's state has been assessed during 7 weeks (1 week--wash out and 6 week--active therapy) clinically and using the Hamilton and CGI scales on 7th, 14th, 21st, 28th and 42nd days. The clinical equivalence of torin and the original drug demonstrated. Torin had a distinct thymoanaleptic effect, the primary action of which addresses anxious affect. This drug was soft as well as zoloft.
authors.forename: E G
authors.initials: EG
authors.lastname: Kostiukova
authors.forename: O V
authors.initials: OV
authors.lastname: Serditov
authors.forename: M Ia
authors.initials: MIa
authors.lastname: Ladyzhenskiĭ
authors.forename: S N
authors.initials: SN
authors.lastname: Mosolov
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020280:Sertraline / Q000031:analogs & derivatives* / Q000627:therapeutic use*
chemical_list: D000928:Antidepressive Agents; D020280:Sertraline