Antiproliferative triterpenes from Melaleuca ericifolia.
Three new 28-norlupane triterpenes, 28-norlup-20(29)-en-3beta-hydroxy-17beta-hydroperoxide (1), 28-norlup-20(29)-en-3beta-hydroxy-17alpha-hydroperoxide (2), and 20 S-17beta,29-epoxy-28-norlupan-3beta-ol (3), were isolated from the leaves of Melaleuca ericifolia along with eight known pentacyclic triterpenes. The structures of the new compounds were elucidated by spectroscopic methods including 1D and 2D NMR spectroscopy and mass spectrometry. The isolated triterpenes were evaluated for antiproliferative activity against the malignant +SA mammary epithelial cell line.
Abdel Bar
Fatma M
FM
Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, 700 University Avenue, Monroe, Louisiana 71209, USA.
Zaghloul
Ahmed M
AM
Bachawal
Sunitha V
SV
Sylvester
Paul W
PW
Ahmad
Kadria F
KF
El Sayed
Khalid A
KA
D000818:Animals; D004354:Drug Screening Assays, Antitumor; D004534:Egypt; D031650:Melaleuca / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
C533000:20S-17beta,29-epoxy-28-norlupan-3beta-ol; C532999:28-norlup-20(29)-en-3beta-hydroxy-17beta-hydroperoxide; D014315:Triterpenes