Degradable and bioresorbable polymers in surgery and in pharmacology: beliefs and facts.
The number of articles dealing with degradable polymers and macromolecules is increasing rapidly and the number of proposed compounds as well. However, not all have a high potential for effective applications. This contribution examines first the criteria to be taken into account when commercialisation of polymeric compounds and devices aimed at helping the body for a limited period of time, i.e. the healing time, is the main goal. What is really known is tentatively analysed by considering some of the candidates present in literature confronted to the targeted potential applications. Tentative comments are made on what should be done to qualify a candidate. Last but not least, trends in the search for polymers to be exploited in presently attracting areas such as bioresorbable stents, hydrogels to deliver bioactive macromolecules like proteins and polynucleotides or polyelectrolytes to temporarily complex charged biomacromolecules like proteins or genes are considered.
Vert
Michel
M
Institute of Biomolecules Max Mousseron, UMR CNRS 5247, Montpellier Cedex 5, France. vertm@univ-montp1.fr
D020341:Absorbable Implants; D000042:Absorption; D001672:Biocompatible Materials / Q000737:chemistry* / Q000627:therapeutic use*; D004343:Drug Implants / Q000737:chemistry*; D010600:Pharmacology / Q000379:methods* / Q000639:trends; D011108:Polymers / Q000737:chemistry*; D019651:Plastic Surgery Procedures / Q000295:instrumentation* / Q000379:methods / Q000639:trends
D001672:Biocompatible Materials; D004343:Drug Implants; D011108:Polymers