Prolapse gastropathy syndrome may be a predictor of pathologic acid reflux.
OBJECTIVE
To assess the occurrence of gastric acid reflux into the esophagus in endoscopically confirmed prolapse gastropathy syndrome (PGS).


METHODS
Using ambulatory esophageal pH measurement (BRAVO(TM) wireless esophageal pH monitoring system), twenty-six patients with PGS were compared with twenty-one patients with erosive esophagitis (EE) as controls. We assessed several reflux parameters, including the percentage of total time at pH < 4, and the DeMeester score.


RESULTS
There were no statistical differences between the PGS group and the EE group as to mean age, sex ratio and pH recording time. The EE group showed more severe reflux than the PGS group, as evaluated in terms of the longest duration of reflux, the number of reflux episodes, the number of reflux episodes lasting > 5 min, the total time with pH < 4 during acid reflux episodes, and the DeMeester score, but none of these parameters showed statistically significant difference. Although 53.8% (14/26) of the PGS group and 76.2% (16/21) of the EE group demonstrated pathologic acid reflux (DeMeester score > 14.72), there was no statistically significant difference between the two groups in the incidence of pathologic acid reflux (P = 0.11).


CONCLUSIONS
There was no statistically significant difference in pathologic acid reflux between the PGS and EE group. These data suggest that endoscopically diagnosed PGS might be a predictor of pathologic acid reflux.
Kim
Jin-Soo
JS
Department of Internal Medicine, Uijeongbu St. Mary's Hospital, 65-1 Geumo-dong, Uijeongbu city, Kyunggido, South Korea.
Kim
Hyung-Keun
HK
Cho
Young-Seok
YS
Chae
Hiun-Suk
HS
Kim
Byung-Wook
BW
Kim
Jin-Il
JI
Han
Sok-Won
SW
Choi
Kyu-Yong
KY
D000328:Adult; D050782:Esophageal pH Monitoring; D004941:Esophagitis / Q000150:complications* / Q000473:pathology; D004945:Esophagoscopy; D005260:Female; D005764:Gastroesophageal Reflux / Q000209:etiology* / Q000473:pathology; D005773:Gastroscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011391:Prolapse; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D013272:Stomach Diseases / Q000150:complications* / Q000473:pathology; D013577:Syndrome