title: Structure elucidation and 1H/13C NMR spectral assignments of four trabectedin related compounds.
abstract: This article presents the structure elucidation of four new compounds, formed during the hemisynthetic preparation of trabectedin, an anti-tumor natural product from Ecteinascidia turbinata. We report herein on the use of UV, MS and NMR spectroscopic data along with (1)H and (13)C spectral assignments obtained by means of 1D and 2D homo- and heteronuclear NMR techniques.
authors.affiliation: Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium. wvermeu2@its.jnj.com
authors.forename: Wim
authors.initials: W
authors.lastname: Vermeulen
authors.forename: Walter
authors.initials: W
authors.lastname: Filliers
authors.forename: Carmen
authors.initials: C
authors.lastname: García
authors.forename: Sonia
authors.initials: S
authors.lastname: Manzanaro
authors.forename: David
authors.initials: D
authors.lastname: Montalvo
authors.forename: Concepción
authors.initials: C
authors.lastname: Polanco
authors.forename: Frank
authors.initials: F
authors.lastname: Spillemaeckers
authors.forename: Bart
authors.initials: B
authors.lastname: Van Hoof
authors.forename: Guido
authors.initials: G
authors.lastname: Winderickx
authors.forename: Ivan
authors.initials: I
authors.lastname: Somers
authors.forename: Ignacio
authors.initials: I
authors.lastname: Rodriguez-Campos
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry; D002247:Carbon Isotopes; D004149:Dioxoles / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D013058:Mass Spectrometry; D015394:Molecular Structure; D013056:Spectrophotometry, Ultraviolet; D044005:Tetrahydroisoquinolines / Q000737:chemistry*; D000077606:Trabectedin; D014561:Urochordata / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D002247:Carbon Isotopes; D004149:Dioxoles; D044005:Tetrahydroisoquinolines; D000077606:Trabectedin