title: Hostility trait and vascular dilatory functions in healthy Taiwanese.
abstract: Aim It has been demonstrated that brief episodes of mental stress can cause transient endothelial dysfunction, which is an important early event in atherogenesis. The purpose of this study is to examine the independent effect of hostility trait on resting endothelial function. Objective A total of 89 healthy adults were recruited. Hostility was measured by the Buss-Durkee Hostility Inventory- Chinese Version- Short Form. Vascular dilatory functions were measured by using ultrasound imaging of the brachial artery before and after cuff occlusion, before and after sublingual nitroglycerin. Conclusion Multiple regression analyses revealed the independent negative effect of hostility on flow-mediated dilation (FMD). And this association is independent from biomedical risk factors and other psychological factors, specifically anxiety and depression. With respect to Nitroglycerin-induced dilation, none of the psychological risk factors were found to have statistically significant contribution.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, The Buddhist Dalin Tzu Chi General Hospital, 2 Min-Sheng Road, Dalin, Chia-Yi, 622, Taiwan, ROC.
authors.forename: Tin Kwang
authors.initials: TK
authors.lastname: Lin
authors.forename: Chia-Ying
authors.initials: CY
authors.lastname: Weng
authors.forename: Wen-Chung
authors.initials: WC
authors.lastname: Wang
authors.forename: Chiu-Chun
authors.initials: CC
authors.lastname: Chen
authors.forename: I-Mei
authors.initials: IM
authors.lastname: Lin
authors.forename: Chin-Lon
authors.initials: CL
authors.lastname: Lin
mesh_terms: D000368:Aged; D050197:Atherosclerosis / Q000523:psychology*; D042783:Endothelial Cells / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006791:Hostility; D006801:Humans; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000494:pharmacology; D012016:Reference Values; D012307:Risk Factors; D012737:Sex Factors; D013315:Stress, Psychological / Q000503:physiopathology* / Q000523:psychology; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D014665:Vasodilator Agents; D005996:Nitroglycerin