[Biliary, pancreatic and systemic diseases associated with IgG4].
Whereas autoimmune pancreatitis is an established entity characterized by high serum concentrations of IgG4, IgG4 cholangitis is a quite new entity characterized by a massive infiltration of bile ducts by IgG4 positive lymphoplasmocytic cells. IgG4 cholangitis should therefore be differentiated from primary sclerosing cholangitis based on clinics, radiological and biological markers. This paper is aimed at reviewing all new aspects of diseases associated with high levels of IgG4.
Frossard
Jean-Louis
JL
Division de gastroentérologie et hépatologie, HUG, 1211 Genève 14. jean-louis.frossard@hcuge.ch
Spahr
Laurent
L
Rubbia-Brandt
Laura
L
Hadengue
Antoine
A
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D058846:Antibodies, Monoclonal, Murine-Derived; D001327:Autoimmune Diseases / Q000276:immunology; D001660:Biliary Tract Diseases / Q000276:immunology*; D002761:Cholangitis / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D015209:Cholangitis, Sclerosing / Q000175:diagnosis; D003937:Diagnosis, Differential; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D007155:Immunologic Factors / Q000627:therapeutic use; D010195:Pancreatitis / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D011379:Prognosis; D000069283:Rituximab
D000305:Adrenal Cortex Hormones; D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D007074:Immunoglobulin G; D007155:Immunologic Factors; D000069283:Rituximab