title: Assembly system of direct modified superparamagnetic iron oxide nanoparticles for target-specific MRI contrast agents.
abstract: We report the direct modification of SPIOs with a biomolecule and the target-specific assembly system of these modified SPIOs for using MRI contrast agents. The transverse relaxation rate of the aqueous solutions containing the modified SPIOs was altered by the dispersion state.
authors.affiliation: Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tanaka
authors.forename: Narufumi
authors.initials: N
authors.lastname: Kitamura
authors.forename: Masahito
authors.initials: M
authors.lastname: Morita
authors.forename: Toshiro
authors.initials: T
authors.lastname: Inubushi
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Chujo
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry; D001710:Biotin / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003287:Contrast Media / Q000737:chemistry / Q000494:pharmacology*; D004247:DNA / Q000737:chemistry; D015195:Drug Design; D005290:Ferric Compounds / Q000737:chemistry*; D006427:Hemin / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008024:Ligands; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D013997:Time Factors
chemical_list: D052157:Aptamers, Nucleotide; D003287:Contrast Media; D005290:Ferric Compounds; D008024:Ligands; C000499:ferric oxide; D001710:Biotin; D006427:Hemin; D004247:DNA