A prospective analysis of the association between dietary fiber intake and prostate cancer risk in EPIC.
Few studies have examined the association between dietary fiber intake and prostate cancer risk. We evaluated the association between dietary fiber intake and the risk of prostate cancer among 142,590 men in the European Prospective Investigation into Cancer and Nutrition (EPIC). Consumption of dietary fiber (total, cereal, fruit and vegetable fiber) was estimated by validated dietary questionnaires and calibrated using 24-hr dietary recalls. Incidence rate ratios were estimated using Cox regression and adjusted for potential confounding factors. During an average of 8.7 years follow-up, prostate cancer was diagnosed in 2,747 men. Overall, there was no association between dietary fiber intake (total, cereal, fruit or vegetable fiber) and prostate cancer risk, although calibrated intakes of total fiber and fruit fiber were associated with nonstatistically significant reductions in risk. There was no association between fiber derived from cereals or vegetables and risk and no evidence for heterogeneity in any of the risk estimates by stage or grade of disease. Our results suggest that dietary fiber intake is not associated with prostate cancer risk.
Suzuki
Reiko
R
Nuffield Department of Medicine, Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom.
Allen
Naomi E
NE
Key
Timothy J
TJ
Appleby
Paul N
PN
Tjønneland
Anne
A
Johnsen
Nina Føns
NF
Jensen
Majken K
MK
Overvad
Kim
K
Boeing
Heiner
H
Pischon
Tobias
T
Kaaks
Rudolf
R
Rohrmann
Sabine
S
Trichopoulou
Antonia
A
Misirli
Gesthimani
G
Trichopoulos
Dimitrios
D
Bueno-de-Mesquita
H Bas
HB
van Duijnhoven
Fränzel
F
Sacerdote
Carlotta
C
Pala
Valeria
V
Palli
Domenico
D
Tumino
Rosario
R
Ardanaz
Eva
E
Quirós
José Ramón
JR
Larrañaga
Nerea
N
Sánchez
Maria-José
MJ
Tormo
María-José
MJ
Jakszyn
Paula
P
Johansson
Ingegerd
I
Stattin
Pär
P
Berglund
Göran
G
Manjer
Jonas
J
Bingham
Sheila
S
Khaw
Kay-Tee
KT
Egevad
Lars
L
Ferrari
Pietro
P
Jenab
Mazda
M
Riboli
Elio
E
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D004032:Diet; D004043:Dietary Fiber / Q000378:metabolism*; D005060:Europe; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D052756:Nutritional Sciences; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000209:etiology*; D012306:Risk