Statin use and the risk of Parkinson disease: a nested case control study.
Using the British Columbia Linked Health Databases, we explored the association between the use of statin drugs and the risk of developing Parkinson disease (PD). We followed a cohort of older adults in the Province of British Columbia from 1997 to 2003. Using a study design of nested case control (case-control study within a cohort), the relative risk of developing PD for statin users was 0.94 (0.82-1.09). Our study did not show a statistically significant effect on the risk of PD with statin use.
Samii
Ali
A
Department of Neurology, University of Washington, Seattle VA Parkinson Disease Research Education and Clinical Center (PADRECC), VA Puget Sound Health Care System, 1660 S. Columbian Way, MS-127, Seattle, WA 98108, USA. asamii@u.washington.edu
Carleton
Bruce C
BC
Etminan
Mahyar
M
D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D015331:Cohort Studies; D016206:Databases, Bibliographic / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D012189:Retrospective Studies; D012306:Risk
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors