Structural development of benzhydrol-type 1'-acetoxychavicol acetate (ACA) analogs as human leukemia cell-growth inhibitors based on quantitative structure-activity relationship (QSAR) analysis.
Benzhydrol-type analogs of 1'-acetoxychavicol acetate (ACA) were developed as inhibitors of human leukemia HL-60 cell growth based on quantitative structure-activity relationship (QSAR) analysis. An analog containing an anthracenyl moiety (8) was a potent inhibitor with the IC(50) value of 0.12 microM.
Misawa
Takashi
T
Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan.
Aoyama
Hiroshi
H
Furuyama
Taniyuki
T
Dodo
Kosuke
K
Sagawa
Morihiko
M
Miyachi
Hiroyuki
H
Kizaki
Masahiro
M
Hashimoto
Yuichi
Y
D000085:Acetates / Q000138:chemical synthesis* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000494:pharmacology*; D001559:Benzhydryl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D018922:HL-60 Cells; D006801:Humans; D007202:Indicators and Reagents; D007938:Leukemia / Q000188:drug therapy* / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D021281:Quantitative Structure-Activity Relationship; D013237:Stereoisomerism
D000085:Acetates; D000972:Antineoplastic Agents, Phytogenic; D001559:Benzhydryl Compounds; D007202:Indicators and Reagents