title: Measurement of tibial endothelial cell function after cigarette smoking, cessation of smoking and hyperbaric oxygen therapy.
abstract: Cigarette smoking is hazardous to a range of human tissues. For instance, cigarette smoke inhalation has been proven to delay bone healing. This study analysed the effects of cigarette smoking on tibial vascular endothelium and blood flow using the bone-chamber model. The effects of smoking cessation and hyperbaric oxygen (HBO) on the damage caused by smoking were also compared. 54 adult New Zealand rabbits were divided into three groups. Group 1: control, Group 2: 1 week smoking, and Group 3: 6 weeks' smoking. This study on rabbits confirmed that both short-term and long-term cigarette smoking is dangerous to the bony vascular endothelium of the tibia. The vasodilatation caused by nitric oxide production was significantly attenuated in Group 2 and 3's tibia. Long-term smoking damaged the vascular endothelium more severely than short-term smoking (P<.01). Cessation of smoking effectively reduces the adverse effects of smoking when the cessation time equals the smoking time. HBO also effectively reduces the adverse effects of smoking.
authors.affiliation: E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
authors.forename: Cheng-Yo
authors.initials: CY
authors.lastname: Yen
authors.forename: Yuan-kun
authors.initials: YK
authors.lastname: Tu
authors.forename: Ching-Hou
authors.initials: CH
authors.lastname: Ma
authors.forename: Jih-Hsi
authors.initials: JH
authors.lastname: Yeh
authors.forename: Feng-Chen
authors.initials: FC
authors.lastname: Kao
authors.forename: Shang-Won
authors.initials: SW
authors.lastname: Yu
authors.forename: Mel S
authors.initials: MS
authors.lastname: Lee
authors.forename: Ying-Chao
authors.initials: YC
authors.lastname: Chou
authors.forename: Steve Wen-Neng
authors.initials: SW
authors.lastname: Ueng
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006931:Hyperbaric Oxygenation; D008297:Male; D023421:Models, Animal; D011817:Rabbits; D012907:Smoking / Q000009:adverse effects*; D016540:Smoking Cessation; D013977:Tibia / Q000098:blood supply*; D016909:Tibial Arteries / Q000187:drug effects / Q000502:physiology; D013997:Time Factors; D019323:omega-N-Methylarginine / Q000008:administration & dosage / Q000378:metabolism
chemical_list: D019323:omega-N-Methylarginine; D000109:Acetylcholine