Synthesis, characterization, and DNA-binding properties of Ln(III) complexes containing gatifloxacin.
Four novel water-soluble complexes of Ln(III) with gatifloxacin (HGA), [La(HGA)3Cl3] x 2H2O, [Nd(HGA)3Cl3] x 2H2O, [Eu(HGA)3Cl3] x 2H2O, [Tb(HGA)3Cl3] x 2H2O, have been synthesized and characterized by elemental analyses, molar conductivities, IR spectra, fluorescence spectra, and thermogravimetry/differential thermal analysis (TG-DTA). In addition, the DNA-binding properties of the ligand and its complexes have been investigated by absorption, fluorescence spectra, and viscosity measurements. The experimental results indicated that the complexes and ligand bind to DNA via groove binding mode.
Liu
Tonghuan
T
College of Chemistry and Chemical Engineering and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China.
Lu
Huili
H
Xi
Pinxian
P
Liu
Xiaohui
X
Xu
Zhihong
Z
Chen
Fengjuan
F
Zeng
Zhengzhi
Z
D000890:Anti-Infective Agents / Q000737:chemistry / Q000378:metabolism; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D024841:Fluoroquinolones / Q000737:chemistry / Q000378:metabolism; D000077734:Gatifloxacin; D007811:Lanthanum / Q000737:chemistry*; D015394:Molecular Structure; D013050:Spectrometry, Fluorescence; D014783:Viscosity
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D007811:Lanthanum; D004247:DNA; D000077734:Gatifloxacin