Hepatitis B virus reactivation after a resolutive acute hepatitis leading to a diagnosis of T cell lymphoma.
A case of hepatitis B virus reactivation leading to the diagnosis of a T cell lymphoma is reported. A 66-year-old woman with a past history (10 years before) of spontaneously recovered acute hepatitis B (with disappearance of serum hepatitis B surface antigen and appearance of anti-HBs), has been referred for hepatologic consultation for acute hepatitis. The patient was found positive again for hepatitis B surface antigen as well HBeAg and hepatitis B virus DNA. No other cause of liver disease was identified and a diagnosis of spontaneous hepatitis B virus reactivation was made. Five months later a peripheral T cell lymphoma was diagnosed. This unusual case confirms that natural immunity is not protective against hepatitis B virus reactivation and shows that such hepatitis B virus reactivation may precede the usual clinical manifestations of a peripheral T cell lymphoma.
Negreanu
L
L
Department of Hepato-gastro-enterology, Trousseau Hospital, Tours Regional University Hospital, Tours, France.
Baty
G
G
Dubois
F
F
de Muret
A
A
Bacq
Y
Y
D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use; D004279:DNA, Viral / Q000097:blood; D017809:Fatal Outcome; D005260:Female; D006509:Hepatitis B / Q000150:complications* / Q000188:drug therapy; D006513:Hepatitis B e Antigens / Q000097:blood; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use; D016399:Lymphoma, T-Cell / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D009364:Neoplasm Recurrence, Local / Q000150:complications* / Q000188:drug therapy; D012008:Recurrence; D012075:Remission, Spontaneous
D000998:Antiviral Agents; D004279:DNA, Viral; D006513:Hepatitis B e Antigens; D019259:Lamivudine