Electrochemical behavior of valsartan and its determination in capsules.
Electrochemical behavior of valsartan has been carried out in Britton-Robinson (B-R) buffer solution at pH 7.0 at the mercury film electrode (MFE) by cyclic, linear sweep, differential-pulse and square-wave voltammetry. The property of valsartan adsorption at the MFE using accumulation potential of +0.10 V was observed. The effects of experimental parameters on electrochemical process at the MFE were discussed. Differential-pulse adsorptive stripping and square-wave adsorptive stripping voltammetry for the valsartan determination were proposed, linearity was found in the range of 6.0 x 10(-8) to 4.0 x 10(-6)mol/L. The detection limits were 2.93 x 10(-9) and 3.27 x 10(-9)mol/L, respectively. The proposed methods were also applied to the commercial valsartan with good recoveries.
Yan
Jinlong
J
School of Chemical and Biological Engineering, Yancheng Institute of Technology, Yancheng 224003, China. yjlyt4788@yahoo.com.cn
Wang
Wei
W
Chen
Liang
L
Chen
Song
S
D002214:Capsules / Q000032:analysis / Q000737:chemistry*; D004563:Electrochemistry / Q000379:methods*; D013777:Tetrazoles / Q000032:analysis* / Q000737:chemistry*; D014633:Valine / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry; D000068756:Valsartan
D002214:Capsules; D013777:Tetrazoles; D000068756:Valsartan; D014633:Valine