title: Effect of Phyllanthus niruri Linn. treatment on liver, kidney and testes in CCl4 induced hepatotoxic rats.
abstract: Phyllanthus niruri extract is extensively used in treating liver ailments. Effects of aqueous extract of P. niruri on liver, kidney and testes of CCl4 induced hepatotoxic rats were studied. High levels of malondialdehyde (MDA) were observed in the CCl4 test group with significant reduction of MDA levels in all groups on P. niruri extract administration. Highest levels of glutathione (GSH) were found in P. niruri group. Activities of alanine transaminase, aspartate transaminase and alkaline phosphatase enzymes were significantly reduced in the curative group (P. niruri treatment after CCl4 injection). Histopathology of liver showed lesser degree of inflammation in all P. niruri treated groups while the renal and seminiferous tubules showed eosinophilic protein casts with signs of tubular damage and degeneration. Testes also showed decreased amount of mature spermatozoa. The results suggest that P. niruri has anti-oxidant and hepato-protective activity with associated deleterious effects on kidney and testes.
authors.affiliation: Department of Biochemistry, Centre for Basic Sciences, Kasturba Medical College, Bejai, Mangalore 575 004, India.
authors.forename: A P
authors.initials: AP
authors.lastname: Manjrekar
authors.forename: V
authors.initials: V
authors.lastname: Jisha
authors.forename: P P
authors.initials: PP
authors.lastname: Bag
authors.forename: B
authors.initials: B
authors.lastname: Adhikary
authors.forename: M M
authors.initials: MM
authors.lastname: Pai
authors.forename: A
authors.initials: A
authors.lastname: Hegde
authors.forename: M
authors.initials: M
authors.lastname: Nandini
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002251:Carbon Tetrachloride / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D008099:Liver / Q000187:drug effects* / Q000293:injuries / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D029803:Phyllanthus / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013737:Testis / Q000187:drug effects* / Q000473:pathology
chemical_list: D010936:Plant Extracts; D002251:Carbon Tetrachloride