title: Materials in surgery: a review of biomaterials in postsurgical tissue adhesion and seroma prevention.
abstract: Postoperative tissue adhesion is a complex inflammatory disorder in which tissues that normally remain separated in the body grow into each other. Seroma is a common postoperative complication that arises when serous fluid collects in the space generated following surgeries that require extensive dissection and that create large empty spaces. Postsurgical tissue adhesion and seroma formation are two serious surgical complications that have received more attention recently from the biomaterials community. This paper provides a review of the pathogenesis and treatment of these surgical complications, with a thorough overview of biomaterial-based treatment and prevention methods.
authors.affiliation: School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York 14853, USA.
authors.forename: Peter N
authors.initials: PN
authors.lastname: Zawaneh
authors.forename: David
authors.initials: D
authors.lastname: Putnam
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002266:Carboxymethylcellulose Sodium / Q000627:therapeutic use; D002483:Cellulose, Oxidized / Q000627:therapeutic use; D003911:Dextrans / Q000627:therapeutic use; D006801:Humans; D006820:Hyaluronic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D007249:Inflammation / Q000517:prevention & control; D023421:Models, Animal; D010743:Phospholipids / Q000627:therapeutic use; D011092:Polyethylene Glycols / Q000627:therapeutic use; D011183:Postoperative Complications / Q000517:prevention & control; D049291:Seroma / Q000517:prevention & control*; D013514:Surgical Procedures, Operative; D000267:Tissue Adhesions / Q000517:prevention & control*
chemical_list: D001672:Biocompatible Materials; D002483:Cellulose, Oxidized; D003911:Dextrans; C060002:INTERCEED; D010743:Phospholipids; C520950:carbylan-SX; D011092:Polyethylene Glycols; D006820:Hyaluronic Acid; D002266:Carboxymethylcellulose Sodium