Dendrimers as size selective inhibitors to protein-protein binding.
This communication describes how the "quantized" size effect of dendrimers can be exploited towards a size selective binding mechanism for the inhibition of protein-protein binding.
Chiba
Fumiko
F
Chemistry Department, University of Sheffield, Sheffield, UK S2 7HF.
Hu
Ting-Chou
TC
Twyman
Lance J
LJ
Wagstaff
Mark
M
D002918:Chymotrypsin / Q000037:antagonists & inhibitors* / Q000737:chemistry; D045304:Cytochromes c / Q000037:antagonists & inhibitors* / Q000737:chemistry; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008024:Ligands; D015394:Molecular Structure; D010316:Particle Size; D011485:Protein Binding / Q000187:drug effects
D050091:Dendrimers; D004791:Enzyme Inhibitors; D008024:Ligands; D045304:Cytochromes c; D002918:Chymotrypsin