title: Non-classical hydrogen bonds in interleukins: the role of C-H...O interactions.
abstract: The role of classical hydrogen bonds in the structural stability of biological macro-molecules is well understood. In the present study, we explore the influence of C-H...O interactions in relation to other environmental preferences in interleukins. Main chain-main chain interactions are predominant. Pro residues might stabilize helices and strands by C-H...O H-bonds in interleukins. Majority of the C-H...O interacting residues were solvent exposed. 62% of C-H...O interactions was long-range interactions. The results presented in this study might be useful for structural stability studies in interleukins.
authors.affiliation: Bioinformatics & Computational Biology Division, School of Biotechnology, Chemical & Biomedical Engineering, Vellore Institute of Technology, Thiruvalam Road, Vellore 632014, India.
authors.forename: Sudha
authors.initials: S
authors.lastname: Anand
authors.forename: Anand
authors.initials: A
authors.lastname: Anbarasu
authors.forename: Rao
authors.initials: R
authors.lastname: Sethumadhavan
mesh_terms: D000596:Amino Acids / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D002244:Carbon / Q000737:chemistry* / Q000378:metabolism; D017124:Conserved Sequence; D006801:Humans; D006859:Hydrogen / Q000737:chemistry* / Q000378:metabolism; D006860:Hydrogen Bonding; D007378:Interleukins / Q000737:chemistry* / Q000378:metabolism*; D008958:Models, Molecular; D010100:Oxygen / Q000737:chemistry* / Q000378:metabolism; D017510:Protein Folding; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary
chemical_list: D000596:Amino Acids; D007378:Interleukins; D002244:Carbon; D006859:Hydrogen; D010100:Oxygen