[Contribution of rennin-angiotensin-aldosterone system genes and NO synthase gene to the development of arterial hypertension].
Arterial hypertension (AH) is one of the most widespread cardiovascular disorders, 39.2% of men and 41.1% of women having elevated arterial pressure (AP). Hence, the necessity to elucidate possible causes of this abnormality. Heredity is considered to be a major factor determining AP in humans, and researchers all over the world are engaged in the search for AP markers. This paper is focused on genes controlling the renin-angiotensin-aldosterone system, viz. genes of angiotensin II, type 1 angiotensin II receptors, angiotensin-converting enzyme, and NO synthase. An overview of population studies with special reference to these genes indicates that molecular-genetic mechanisms of AH remain unclear. Joint efforts of researchers working in different centres are needed to address the problem.
Savinetskaia
G A
GA
Golubeva
A A
AA
Pogoda
T V
TV
Generozov
E V
EV
D015870:Gene Expression / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D019001:Nitric Oxide Synthase / Q000235:genetics*; D012084:Renin-Angiotensin System / Q000235:genetics*
D019001:Nitric Oxide Synthase