JTT-705: is there still future for a CETP inhibitor after torcetrapib?
BACKGROUND
Despite reduction in low-density lipoprotein cholesterol, there is still a considerable amount of residual atherosclerosis-related disease. Epidemiological and pathophysiological data strongly favour increasing plasma high-density lipoprotein (HDL) cholesterol levels as antiatherogenic therapy, for example with cholesteryl ester transfer inhibition (CETP). However, negative Phase III studies on clinical end points with the CETP inhibitor torcetrapib challenge the future perspectives of other CETP inhibitors such as JTT-705.


OBJECTIVE
Is there potential for CETP inhibition with JTT-705 after torcetrapib's collapse?


METHODS
Search of articles in Pubmed citing JTT-705, torcetrapib and anacetrapib, or citing effects of pharmacological HDL-cholesterol raising or CETP inhibition.


CONCLUSIONS
There is possibly a future for HDL-cholesterol raising therapies. Phase III clinical studies with either JTT-705 or anacetrapib will determine whether CETP inhibition is beneficial.
Rennings
Alexander J M
AJ
Radboud University Nijmegen Medical Centre, Department of Internal Medicine, 460, PO Box 9101, 6500 HB Nijmegen, The Netherlands. a.rennings@AIG.umcn.nl
Stalenhoef
Anton  F H
A
D000577:Amides; D000818:Animals; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D002784:Cholesterol / Q000378:metabolism; D053480:Cholesterol Ester Transfer Proteins / Q000037:antagonists & inhibitors* / Q000502:physiology; D008076:Cholesterol, HDL / Q000097:blood; D002986:Clinical Trials as Topic; D004952:Esters; D006801:Humans; D011804:Quinolines / Q000627:therapeutic use*; D013438:Sulfhydryl Compounds / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*
D000577:Amides; D000924:Anticholesteremic Agents; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL; D004952:Esters; D011804:Quinolines; D013438:Sulfhydryl Compounds; C411602:dalcetrapib; C483909:torcetrapib; D002784:Cholesterol