Novel strategies to improve the anticancer action of 5-fluorouracil by using drug delivery systems.
Because of the fundamental importance of new therapeutic routes for cancer treatment, a number of systems based on colloidal particles as vehicles for the delivery of the anticancer drug 5-fluorouracil have been devised. The target is always to provide the proper dose of the antitumor agent only at the desired locus of action, thus reducing the unwanted side effects. In this review, the main strategies and the more significant results in the development of 5-fluorouracil carriers for cancer treatment are discussed.
Arias
José L
JL
Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Campus Universitario de Cartuja s/n, 18071 Granada, Spain. jlarias@ugr.es
D000970:Antineoplastic Agents; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D005472:Fluorouracil / Q000008:administration & dosage*; D006801:Humans; D011108:Polymers / Q000737:chemistry / Q000627:therapeutic use
D000970:Antineoplastic Agents; D004337:Drug Carriers; D011108:Polymers; D005472:Fluorouracil