title: Short-term hypoxia reduces arterial stiffness in healthy men.
abstract: This study examined the effects of hypoxia (80% arterial oxyhaemoglobin saturation for 20 min) and the accompanying changes in heart rate and blood pressure on two components of arterial stiffness in healthy men. Augmentation index (AIx) and time to reflection (Tr) representing measures of muscular artery and aortic stiffness, respectively, were continuously measured. At first, subjects were exposed to either hypoxia (n = 12) or room air (n = 5). During early hypoxia AIx increased by 6% before decreasing to baseline. After hypoxia AIx decreased by a further 6%. In contrast there was no change in Tr. Six subjects were then exposed to hypoxia following infusion with the nitric oxide (NO) synthase inhibitor NG-mono-methyl-L: -arginine (L-NMMA) or saline. During hypoxia AIx decreased by 12% following saline but increased by 14% after L-NMMA and Tr did not change. These findings suggest that hypoxia may induce NO-mediated vasodilatation of small muscular arteries but not the aorta.
authors.affiliation: Woolcock Institute of Medical Research, Sydney, NSW, 2050, Australia.
authors.forename: Hima
authors.initials: H
authors.lastname: Vedam
authors.forename: Craig L
authors.initials: CL
authors.lastname: Phillips
authors.forename: David
authors.initials: D
authors.lastname: Wang
authors.forename: David J
authors.initials: DJ
authors.lastname: Barnes
authors.forename: Jan A
authors.initials: JA
authors.lastname: Hedner
authors.forename: Gunnar
authors.initials: G
authors.lastname: Unger
authors.forename: Ronald R
authors.initials: RR
authors.lastname: Grunstein
mesh_terms: D000328:Adult; D001158:Arteries / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D009569:Nitric Oxide / Q000494:pharmacology; D014655:Vascular Resistance / Q000502:physiology; D014664:Vasodilation / Q000502:physiology
chemical_list: D009569:Nitric Oxide