Thrombosis of the cerebral veins and sinuses in acute promyelocytic leukemia after all-trans retinoic acid treatment: a case report.
Thrombosis of the cerebral veins or sinuses is a rare cerebrovascular disorder, which seldom represents a complication of acute promyelocytic leukemia. To the best of our knowledge, it never occurred during treatment with all-trans retinoic acid. We report a case of a 35-year-old woman affected by acute promyelocytic leukemia, who developed massive thrombosis of the cerebral sinuses and veins when she was in complete morphological and molecular remission after all-trans retinoic acid and idarubicin treatment. Anticoagulant therapy contributed to progressive dissolution of the thrombosis as documented by magnetic resonance imaging with complete disappearance of neurological signs without sequelae.
Ciccone
Maria
M
Hematology Section, Department of Biomedical Sciences, University of Ferrara, Corso Giovecca 203, Ferrara, Italy. maria.ciccone@unife.it
Rigolin
Gian Matteo
GM
Viglione
Giulia Marta
GM
Borrelli
Massimo
M
Serino
Maria Luisa
ML
Cuneo
Antonio
A
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D002543:Cerebral Hemorrhage / Q000139:chemically induced*; D005260:Female; D006801:Humans; D015255:Idarubicin / Q000008:administration & dosage; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy*; D012851:Sinus Thrombosis, Intracranial / Q000139:chemically induced*; D013927:Thrombosis / Q000139:chemically induced* / Q000517:prevention & control; D014212:Tretinoin / Q000008:administration & dosage / Q000009:adverse effects*
D014212:Tretinoin; D015255:Idarubicin