[Effect of phenylcarboxylic acids on phagocytic activity of neutrophils].
Neutrophylic phagocytosis is affected by a lot of factors, including phenylcarboxylic acids secreted by bacteria into blood to protect from phagocytosis. The paper describes the most likely mechanism of inhibiting action of these acids, which is associated with the formation of strong pi-complexes between the pi-bonds of the molecular benzene ring of the acids and pi-bonds of unsaturated fatty acid molecules of the neutrophilic membrane. This fact was used to calculate the minimum inhibitory concentration of an acid and to show that there may be saturation in inhibition from the concentration. The experiment wherein the acids were added to blood at varying concentrations has confirmed the inhibitory effect of the acids, as well as saturation. Data processing indicates the unifactor inhibition of phagocytosis and confirms the postulated exponential inhibition at acid concentrations of to about 10(-7) mole/l. There is saturation with further acid concentration increases and there is a further reduced phagocytosis due to the influence of pH at a concentration of more than 10(-5) mole/l.
Zolotarev
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D001565:Benzoates / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D062385:Hydroxybenzoates / Q000494:pharmacology; D066298:In Vitro Techniques; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology; D010587:Phagocytosis; D010648:Phenylacetates / Q000494:pharmacology*; D010666:Phenylpropionates / Q000494:pharmacology*; D011137:Polystyrenes; D013329:Structure-Activity Relationship
D001565:Benzoates; D062385:Hydroxybenzoates; D010648:Phenylacetates; D010666:Phenylpropionates; D011137:Polystyrenes; C008070:4-hydroxyphenylacetic acid; C008869:phloretic acid; C025136:phenylacetic acid