title: [Analysis of designer drugs detected in the products purchased in fiscal year 2006].
abstract: Many psychotropic substances are easily available in Japan via the Internet, thus the spread of drug abuse is becoming more serious problem. To avoid drug abuse, 32 substances have been controlled in Japan since April in 2007 by the Pharmaceutical Affairs Law as designated substances (Shitei-Yakubutsu, classified as 11 tryptamines, 11 phenethylamines, 2 piperazines, 6 alkyl nitrites, 1 diterpene and 1 plant). Although the distributions of these drugs have been decreased through this regulation, new designer drugs are still being found. In this study, we detected 7 designer drugs in 15 products, which purchased just before the amendment of the law, by NMR, GC-MS and LC-MS analyses. Three methylone derivertives (1-(3,4-methylenedioxyphenyl-2-(pyrrolidin-1-yl)-1-pentanone: MDPV, 2-methylamino-1-(3,4-methylenedioxyphenyl)butan-1-one: bk-MBDB, 2-ethylamino-1-(3,4-methylenedioxyphenyl)propan-1-one): bk-MDEA, a MDMA derivative (N-hydroxy-1-(3,4-methylenedioxyphenyl)-2-aminopropane: N-OH MDMA), a methamphetamine derivative (N-methyl-1-(4-fluorophenyl)propan-2-amine: N-Me-4-FMP), a tryptamine derivative (5-methoxy-N-ethyl-N-isopropyltryptamine: 5-MeO-EIPT) and indan-2-amine were detected. 5-MeO-EIPT was newly identified in this study.
authors.affiliation: National Institute of Health Sciences, Tokyo, Japan. nuchiyama@nihs.go.jp
authors.forename: Nahoko
authors.initials: N
authors.lastname: Uchiyama
authors.forename: Ruri
authors.initials: R
authors.lastname: Kikura-Hanajiri
authors.forename: Nobuo
authors.initials: N
authors.lastname: Kawahara
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Goda
mesh_terms: D002853:Chromatography, Liquid; D015198:Designer Drugs / Q000032:analysis*; D004335:Drug and Narcotic Control / Q000331:legislation & jurisprudence; D008401:Gas Chromatography-Mass Spectrometry; D007564:Japan; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008694:Methamphetamine / Q000031:analogs & derivatives / Q000032:analysis; D019966:Substance-Related Disorders / Q000517:prevention & control; D013997:Time Factors; D014363:Tryptamines / Q000032:analysis
chemical_list: D015198:Designer Drugs; D014363:Tryptamines; C030820:tryptamine; D008694:Methamphetamine; C400939:methylone