Cytotoxicity of new stilbenoids from Pholidota chinensis and their spin-labeled derivatives.
Chemical investigation of the leave and stem of Pholidota chinensis Lindl has resulted in the isolation and characterization of three new stilbenoids. Their structures were established on the basis of spectroscopic evidence. A series of spin-labeled stilbene derivatives were synthesized. All of the new compounds were tested for cytotoxicity, and the results revealed that most of the spin-labeled stilbene derivatives showed superior cytotoxicity in vitro.
Wu
Bin
B
Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310027, P. R. China.
Qu
Haibin
H
Cheng
Yiyu
Y
D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D029595:Orchidaceae / Q000737:chemistry*; D013113:Spin Labels; D013267:Stilbenes / Q000737:chemistry* / Q000633:toxicity*; D013329:Structure-Activity Relationship
D013113:Spin Labels; D013267:Stilbenes