title: L-selectride-mediated highly diastereoselective asymmetric reductive aldol reaction: access to an important subunit for bioactive molecules.
abstract: L-selectride reduction of a chiral or achiral enone followed by reaction of the resulting enolate with optically active alpha-alkoxy aldehydes proceeded with excellent diastereoselectivity. The resulting alpha,alpha-dimethyl-beta-hydroxy ketones are inherent to a variety of biologically active natural products.
authors.affiliation: Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA. akghosh@purdue.edu
authors.forename: Arun K
authors.initials: AK
authors.lastname: Ghosh
authors.forename: Jorden
authors.initials: J
authors.lastname: Kass
authors.forename: David D
authors.initials: DD
authors.lastname: Anderson
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Xu
authors.forename: Christine
authors.initials: C
authors.lastname: Marian
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D001688:Biological Products / Q000737:chemistry; D001880:Boranes / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D001688:Biological Products; D001880:Boranes; C533353:selectride; C116609:3-hydroxybutanal