title: A prospective analysis of the association between dietary fiber intake and prostate cancer risk in EPIC.
abstract: Few studies have examined the association between dietary fiber intake and prostate cancer risk. We evaluated the association between dietary fiber intake and the risk of prostate cancer among 142,590 men in the European Prospective Investigation into Cancer and Nutrition (EPIC). Consumption of dietary fiber (total, cereal, fruit and vegetable fiber) was estimated by validated dietary questionnaires and calibrated using 24-hr dietary recalls. Incidence rate ratios were estimated using Cox regression and adjusted for potential confounding factors. During an average of 8.7 years follow-up, prostate cancer was diagnosed in 2,747 men. Overall, there was no association between dietary fiber intake (total, cereal, fruit or vegetable fiber) and prostate cancer risk, although calibrated intakes of total fiber and fruit fiber were associated with nonstatistically significant reductions in risk. There was no association between fiber derived from cereals or vegetables and risk and no evidence for heterogeneity in any of the risk estimates by stage or grade of disease. Our results suggest that dietary fiber intake is not associated with prostate cancer risk.
authors.affiliation: Nuffield Department of Medicine, Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom.
authors.forename: Reiko
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authors.lastname: Suzuki
authors.forename: Naomi E
authors.initials: NE
authors.lastname: Allen
authors.forename: Timothy J
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authors.forename: Paul N
authors.initials: PN
authors.lastname: Appleby
authors.forename: Anne
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authors.forename: Nina Føns
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authors.lastname: Johnsen
authors.forename: Majken K
authors.initials: MK
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authors.forename: Kim
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authors.lastname: Overvad
authors.forename: Heiner
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authors.lastname: Trichopoulou
authors.forename: Gesthimani
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authors.lastname: Misirli
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Trichopoulos
authors.forename: H Bas
authors.initials: HB
authors.lastname: Bueno-de-Mesquita
authors.forename: Fränzel
authors.initials: F
authors.lastname: van Duijnhoven
authors.forename: Carlotta
authors.initials: C
authors.lastname: Sacerdote
authors.forename: Valeria
authors.initials: V
authors.lastname: Pala
authors.forename: Domenico
authors.initials: D
authors.lastname: Palli
authors.forename: Rosario
authors.initials: R
authors.lastname: Tumino
authors.forename: Eva
authors.initials: E
authors.lastname: Ardanaz
authors.forename: José Ramón
authors.initials: JR
authors.lastname: Quirós
authors.forename: Nerea
authors.initials: N
authors.lastname: Larrañaga
authors.forename: Maria-José
authors.initials: MJ
authors.lastname: Sánchez
authors.forename: María-José
authors.initials: MJ
authors.lastname: Tormo
authors.forename: Paula
authors.initials: P
authors.lastname: Jakszyn
authors.forename: Ingegerd
authors.initials: I
authors.lastname: Johansson
authors.forename: Pär
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authors.lastname: Stattin
authors.forename: Göran
authors.initials: G
authors.lastname: Berglund
authors.forename: Jonas
authors.initials: J
authors.lastname: Manjer
authors.forename: Sheila
authors.initials: S
authors.lastname: Bingham
authors.forename: Kay-Tee
authors.initials: KT
authors.lastname: Khaw
authors.forename: Lars
authors.initials: L
authors.lastname: Egevad
authors.forename: Pietro
authors.initials: P
authors.lastname: Ferrari
authors.forename: Mazda
authors.initials: M
authors.lastname: Jenab
authors.forename: Elio
authors.initials: E
authors.lastname: Riboli
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D004032:Diet; D004043:Dietary Fiber / Q000378:metabolism*; D005060:Europe; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D052756:Nutritional Sciences; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000209:etiology*; D012306:Risk