title: Sleep disturbance and daytime sleepiness in patients with cirrhosis: a case control study.
abstract: Sleep disturbance and excessive daytime sleepiness have been reported in patients with hepatic cirrhosis. The objective of this study was to evaluate daytime somnolence and sleep complaints in a group of 178 patients with cirrhosis compared to a control group. Sleep features and excessive daytime sleepiness were evaluated by the Basic Nordic Sleep Questionnaire (BNSQ) and the Epworth Sleepiness Scale (ESS). We collected clinical and laboratory data, neurological assessment and EEG recordings in cirrhotic patients. Patients with cirrhosis complained of more daytime sleepiness (p<0.005), sleeping badly at least three times a week (p<0.005), difficulties falling asleep (p<0.01) and frequent nocturnal awakening (p<0.005) than controls. We found a poor correlation between sleep disorders and clinical or laboratory parameters. Our results confirm previous literature reports suggesting a high prevalence of sleep disturbance in patients with cirrhosis. Insomnia and daytime sleepiness are the main complaints. Sleep disorders are probably a multifactorial phenomenon.
authors.affiliation: Neurology Unit, S. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Mostacci
authors.forename: Monica
authors.initials: M
authors.lastname: Ferlisi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Baldi Antognini
authors.forename: Claudia
authors.initials: C
authors.lastname: Sama
authors.forename: Cristina
authors.initials: C
authors.lastname: Morelli
authors.forename: Susanna
authors.initials: S
authors.lastname: Mondini
authors.forename: Fabio
authors.initials: F
authors.lastname: Cirignotta
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D015897:Comorbidity; D005260:Female; D006501:Hepatic Encephalopathy / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012890:Sleep; D007319:Sleep Initiation and Maintenance Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D012894:Sleep Stages; D012893:Sleep Wake Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D011795:Surveys and Questionnaires; D055815:Young Adult