Prognosis of oocyte donation cycles: a prospective comparison of the in vitro fertilization-embryo transfer cycles of recipients who used shared oocytes versus those who used altruistic donors.
OBJECTIVE
To prospectively compare the prognosis of IVF-ET cycles using oocyte sharing vs. cycles using altruistic donors.


METHODS
Prospective cohort prognostic study.


METHODS
University teaching hospital.


METHODS
A total of 353 consecutive infertile women with premature ovarian failure or diminished ovarian function.


METHODS
After receipt of institutional ethics approval, IVF-ET was performed with the use of either oocyte sharing (n = 220) or altruistic donors (n = 133). Continuous data (mean + SD [95% confidence interval]) were compared with Student's t test or Mann-Whitney test as appropriate; categoric data were compared with Fisher's exact test, odds ratios (OR), and relative risk (RR). Two-tailed P<.05 was considered significant. Logistic regression was used to adjust for confounding variables.


METHODS
The primary endpoint was clinical pregnancy. The secondary endpoints were E(2) dosage, endometrial thickness, fertilization, embryo quality, and rates of embryo cleavage, transfer, and implantation, positive beta-hCG, and biochemical, ectopic, and multiple pregnancy.


RESULTS
There was no statistically significant difference in clinical pregnancy rates (28.18% vs. 30.08%; OR 0.91 [0.49-1.67]; RR 1.07 [0.69-1.65]; adjusted OR 0.95 [0.51-1.78]). The mean E(2) dosage, endometrial thickness, fertilization rate, embryo score, embryo cleavage, number of embryos transferred, and rates of implantation, positive beta-hCG, and biochemical, ectopic, and multiple pregnancy were similar.


CONCLUSIONS
The prognosis with use of shared oocytes is similar to that with altruistic donors.
Oyesanya
Olufunso A
OA
Assisted Conception Unit, Birmingham Women's Hospital, Birmingham, United Kingdom; University of Birmingham, Birmingham, United Kingdom. Electronic address: Olufunso.Oyesanya@kellogg.ox.ac.uk.
Olufowobi
Olufemi
O
Assisted Conception Unit, Birmingham Women's Hospital, Birmingham, United Kingdom.
Ross
Wendy
W
Assisted Conception Unit, Birmingham Women's Hospital, Birmingham, United Kingdom.
Sharif
Khaldoun
K
Assisted Conception Unit, Birmingham Women's Hospital, Birmingham, United Kingdom.
Afnan
Masoud
M
Assisted Conception Unit, Birmingham Women's Hospital, Birmingham, United Kingdom; University of Birmingham, Birmingham, United Kingdom.
D000328:Adult; D015331:Cohort Studies; D004624:Embryo Transfer / Q000379:methods*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006785:Hospitals, University; D006801:Humans; D007247:Infertility, Female / Q000175:diagnosis / Q000628:therapy; D016015:Logistic Models; D008597:Menstrual Cycle / Q000502:physiology*; D018587:Oocyte Donation / Q000379:methods*; D009865:Oocytes / Q000502:physiology*; D011247:Pregnancy; D018873:Pregnancy Rate; D011379:Prognosis; D011446:Prospective Studies; D014019:Tissue Donors; D016896:Treatment Outcome