Axial 4,4',6,6'-tetrakis-trifluoromethyl-biphenyl-2,2'-diamine (TF-BIPHAM): resolution and applications in asymmetric hydrogenation.
The racemic TF-BIPHAM was resolved for the first time, and the effectiveness of the resolved diamine was demonstrated by highly enantioselective hydrogenation of alpha-aryl enamides and alpha-dehydroamino acid esters using readily accessible bis(aminophosphine) ligands.
Wang
Chun-Jiang
CJ
College of Chemistry and Molecular Sciences, Wuhan University, 430072, China. cjwang@whu.edu.cn
Gao
Feng
F
Liang
Gang
G