Enantiopure 2-substituted glyceraldehyde derivatives by aza-Claisen rearrangement or C-alkylation of enamines.
2-Alkyl derivatives of butane-2,3-diacetal (BDA) protected glyceraldehyde were stereoselectively prepared by aza-Claisen rearrangement of N-allyl-enammonium ions or C-alkylation of enamines. This allows rapid and convenient access to densely functionalized chiral building blocks.
Bridgwood
Katy L
KL
Department of Chemistry, Lensfield Road, Cambridge, CB2 1EW, UK.
Tzschucke
C Christoph
CC
O'Brien
Matthew
M
Wittrock
Sven
S
Goodman
Jonathan M
JM
Davies
John E
JE
Logan
Angus W J
AW
Hüttl
Matthias R M
MR
Ley
Steven V
SV