title: Animal models of sepsis and its complications.
abstract: Most currently used animal sepsis models fail to adequately replicate the clinical problem and, therefore, have only limited utility for investigating pathophysiological mechanisms or testing the efficacy of new therapeutic agents. Recent experimental findings support this view and suggest that models of acute infection in mice with pre-existing renal dysfunction may be useful in the development pathway for new therapeutic agents for sepsis.
authors.affiliation: Logical Therapeutics Inc., Waltham, Massachusetts, USA. finkmp@ccm.upmc.edu
authors.forename: Mitchell P
authors.initials: MP
authors.lastname: Fink
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents; D004195:Disease Models, Animal; D007674:Kidney Diseases / Q000150:complications* / Q000188:drug therapy; D018805:Sepsis / Q000150:complications / Q000188:drug therapy
chemical_list: D000890:Anti-Infective Agents