Vitamin E dependent microRNA regulation in rat liver.
Dietary vitamin E (VE) is known to regulate gene expression by altering mRNA concentrations. Recently, microRNA (miRNA) have been discovered as a means of posttranscriptional gene regulation. Since the effect of VE on miRNA regulation is unknown, we fed rats for 6 months diets deficient or sufficient in VE and determined hepatic concentrations of miRNA involved in processes previously associated with VE (lipid metabolism, miRNA-122a; cancer and inflammation, miRNA-125b). VE-deficiency resulted in reduced concentrations of miRNA-122a and miRNA-125b. The findings of the present study demonstrate that differences in dietary VE may affect hepatic miRNA concentrations in vivo.
Gaedicke
Sonja
S
Institute of Human Nutrition and Food Science, Christian-Albrechts-University of Kiel, Hermann-Rodewald-Strasse 6, 24118 Kiel, Germany.
Zhang
Xiangnan
X
Schmelzer
Constance
C
Lou
Yijia
Y
Doering
Frank
F
Frank
Jan
J
Rimbach
Gerald
G
D000818:Animals; D001483:Base Sequence; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D004032:Diet; D005786:Gene Expression Regulation / Q000187:drug effects; D007249:Inflammation / Q000235:genetics; D050356:Lipid Metabolism / Q000187:drug effects / Q000235:genetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D035683:MicroRNAs / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344; D014810:Vitamin E / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology
D035683:MicroRNAs; D014810:Vitamin E