Origin of enantioselectivity in CF3-PIP-catalyzed kinetic resolution of secondary benzylic alcohols.
Computational studies provide support for the involvement of intermolecular pi-interactions in the chiral recognition of secondary benzylic alcohols by the enantioselective acyl transfer catalyst CF3-PIP.
Li
Ximin
X
Department of Chemistry, Washington University, One Brookings Drive, St. Louis, Missouri 63130, USA.
Liu
Peng
P
Houk
K N
KN
Birman
Vladimir B
VB
D001592:Benzyl Alcohols / Q000737:chemistry*; D002384:Catalysis; D003198:Computer Simulation; D018360:Crystallography, X-Ray; D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry; D007700:Kinetics; D008956:Models, Chemical; D008958:Models, Molecular; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*; D013237:Stereoisomerism
C510439:2-phenyl-6-trifluoromethyl-dihydroimidazo(1,2-a)pyridine; D001592:Benzyl Alcohols; D004952:Esters; D011725:Pyridines