title: [Progress in Japanese herbal medicine in treatment of chronic kidney disease].
abstract: In Japan, Saireito and Onpi-to are widely used Japanese herbal medicine in the treatment of chronic kidney disease (CKD), which is a world-wide public health issue. In this review, it has been discussed the beneficial effects of Japanese herbal medicine, including Sairei-to and Onpi-to on multifarious renal damage in progression of CKD, such as mesangial lesion, inflammatory cell infiltration, cytokine expression, reactive oxygen species release, and aldosterone disorder, and then to clarify the mechanism of these herbs at molecular level by examining the effects on various injurious factors. Both Saireito and Onpi-to are effective agents for delaying the progression of CKD.
authors.affiliation: Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Yi-Gang
authors.initials: YG
authors.lastname: Wan
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
authors.forename: Hui-Lan
authors.initials: HL
authors.lastname: Zhang
authors.forename: Ping
authors.initials: P
authors.lastname: Chen
authors.forename: Jian
authors.initials: J
authors.lastname: Yao
mesh_terms: D000818:Animals; D002908:Chronic Disease / Q000188:drug therapy; D029001:Herbal Medicine / Q000639:trends*; D006801:Humans; D007564:Japan; D007674:Kidney Diseases / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008517:Phytotherapy / Q000639:trends*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D010936:Plant Extracts