title: Radiation-induced sarcomas of the head and neck.
abstract: The aim of this study was to report our experience on the management of radiation-induced sarcomas (RISs). A retrospective study from 1994 to 2003 was done at our institution reviewing the medical records of 5 patients who had RISs. Five patients diagnosed of head and neck cancer received irradiation to treat their diseases. Later on, these patients developed new neoplasms in the irradiation fields (3 malignant fibrous histiocytoma, 1 osteosarcoma, and 1 angiosarcoma). The mean period of latency between irradiation and diagnosis of new tumors was 13 years. Early symptoms included neck or face swelling, odynophagia, or trigeminal hypoesthesia. All of the patients underwent surgical treatment. In 4 cases, regional and free flaps for head and neck reconstruction were required. Three patients also needed neoadjuvant chemotherapy. In the follow-up, 2 patients are alive and free of disease. Wide excision is the treatment of choice for RISs. Previous radiation therapy limits the dose that can be administered to the involved area, and the response rate to the chemotherapy is always poor.
authors.affiliation: Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo Asturias, Spain.
authors.forename: Virginia
authors.initials: V
authors.lastname: Franco Gutiérrez
authors.forename: José Luis
authors.initials: JL
authors.lastname: Llorente Pendás
authors.forename: Andrés
authors.initials: A
authors.lastname: Coca Pelaz
authors.forename: Rubén
authors.initials: R
authors.lastname: Cabanillas Farpón
authors.forename: Carlos
authors.initials: C
authors.lastname: Suárez Nieto
mesh_terms: D000328:Adult; D000368:Aged; D016371:Cranial Irradiation / Q000009:adverse effects*; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000209:etiology* / Q000532:radiotherapy / Q000601:surgery; D006394:Hemangiosarcoma / Q000209:etiology / Q000601:surgery; D051677:Histiocytoma, Malignant Fibrous / Q000209:etiology / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009381:Neoplasms, Radiation-Induced / Q000188:drug therapy / Q000601:surgery*; D016609:Neoplasms, Second Primary / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D012516:Osteosarcoma / Q000209:etiology / Q000601:surgery; D012189:Retrospective Studies; D012509:Sarcoma / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D055815:Young Adult