Effect of PEG amount in amorphous calcium phosphate on its crystallized products.
Biphasic alpha-tricalcium phosphate/beta-tricalcium phosphate (alpha/beta-TCP) with a designed phase ratio is thought to have controllable dissolution-reprecipitation behavior that is significant in the repair and regeneration of bone. Amorphous calcium phosphate (ACP) was selected as a precursor to prepare biphasic alpha/beta-TCP. The influence of polyethylene glycol (PEG) content in ACP on its crystallization, or on the phase ratio of the resulting biphasic TCP, was investigated. ACP was synthesized by the reaction of Ca(NO(3))(2) with (NH(4))(2)HPO(4) using PEG as an additive. Depending on the amount of PEG addition, resulting ACP could be crystallized to alpha-TCP, beta-TCP or biphasic alpha/beta-TCP after heat-treatment at 800 degrees C, showing that PEG addition is a critical factor to tailor the phase ratio of biphasic alpha/beta-TCP. One reason for the influence of PEG is that ACP with different PEG content could have two types of unit structures that tend to form alpha-TCP and beta-TCP after crystallization.
Liu
Siqian
S
Department of Materials Science & Engineering, Zhejiang University, Hangzhou, 310027, China.
Weng
Wenjian
W
Li
Zhongli
Z
Pan
Lili
L
Cheng
Kui
K
Song
Chenlu
C
Du
Piyi
P
Shen
Ge
G
Han
Gaorong
G
D018786:Bone Substitutes / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D003460:Crystallization; D008422:Materials Testing; D046529:Microscopy, Electron, Transmission; D011092:Polyethylene Glycols / Q000737:chemistry*; D013816:Thermodynamics; D014961:X-Ray Diffraction
D018786:Bone Substitutes; D002130:Calcium Phosphates; C485828:alpha-tricalcium phosphate; C485817:beta-tricalcium phosphate; D011092:Polyethylene Glycols; C020243:calcium phosphate