Endothelium as master regulator of organ development and growth.
Development of the vasculature is one of the earliest events during embryogenesis, preceding organ formation. Organogenesis requires a complex set of paracrine signals between the vasculature and the developing nonvascular tissues to support differentiation and organ growth. However, the role of endothelium in controlling organ growth and, ultimately, size is little-understood. In this review, we summarize new data regarding the endothelium function in order to provide a more comprehensive understanding of the communication between the endothelium and the organ's tissue.
Tirziu
Daniela
D
Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.
Simons
Michael
M
D000818:Animals; D002454:Cell Differentiation; D047108:Embryonic Development / Q000502:physiology*; D004730:Endothelium, Vascular / Q000166:cytology / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D018919:Neovascularization, Physiologic; D038081:Organogenesis / Q000502:physiology*; D019899:Paracrine Communication / Q000502:physiology; D015398:Signal Transduction