title: Thymidine-dependent Staphylococcus aureus small-colony variants: human pathogens that are relevant not only in cases of cystic fibrosis lung disease.
abstract: We report the isolation of thymidine-dependent small-colony variants (TD-SCVs) of Staphylococcus aureus from unusual infection sites of patients with chronic soft tissue infection, tympanitis, bronchitis, peritonitis, and septicemia. Furthermore, we provide evidence that the essential growth factor for TD-SCVs, i.e., thymidine, and its metabolite dTMP are present in various human specimens.
authors.affiliation: Institute of Medical Microbiology and Infection Control, Hospital of Johann Wolfgang Goethe-University, Frankfurt/Main, Paul-Ehrlich-Strasse 40, 60596 Frankfurt/Main, Germany. s.besier@em.uni-frankfurt.de
authors.forename: Silke
authors.initials: S
authors.lastname: Besier
authors.forename: Johannes
authors.initials: J
authors.lastname: Zander
authors.forename: Ekkehard
authors.initials: E
authors.lastname: Siegel
authors.forename: Stephan H
authors.initials: SH
authors.lastname: Saum
authors.forename: Klaus-Peter
authors.initials: KP
authors.lastname: Hunfeld
authors.forename: Annabelle
authors.initials: A
authors.lastname: Ehrhart
authors.forename: Volker
authors.initials: V
authors.lastname: Brade
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Wichelhaus
mesh_terms: D000328:Adult; D001991:Bronchitis / Q000382:microbiology; D002648:Child; D003550:Cystic Fibrosis / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010538:Peritonitis / Q000382:microbiology; D011014:Pneumonia / Q000382:microbiology; D018805:Sepsis / Q000382:microbiology; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000254:growth & development* / Q000302:isolation & purification / Q000378:metabolism / Q000472:pathogenicity*; D013936:Thymidine / Q000378:metabolism*
chemical_list: D013936:Thymidine