Topical cidofovir for severe warts in a patient affected by AIDS and Hodgkin's lymphoma.
We describe a 42-year-old man with AIDS and Hodgkin's lymphoma whose severe and recalcitrant cutaneous warts resolved following treatment with local 1% cidofovir. Clinically significant improvements were observed in a two-week period of therapy. In advanced HIV disease complicated by additional haematological malignancy, cutaneous warts may be difficult to treat and present a challenge for the attending physicians. In similar clinical condition topical anti-human papillomavirus therapy may prove to be safe and curative.
De Socio
G V L
GV
Department of Infectious Diseases, Santa Maria della Misericordia Hospital, University of Perugia, Perugia, Italy. giuseppedesocio@yahoo.it
Simonetti
S
S
Rosignoli
D
D
Minga
P
P
Tomassini
G M
GM
Baldelli
F
F
D000287:Administration, Topical; D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D000077404:Cidofovir; D003596:Cytosine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005528:Foot; D015658:HIV Infections / Q000150:complications*; D006225:Hand; D006689:Hodgkin Disease / Q000150:complications*; D052162:Human papillomavirus 16 / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000150:complications*; D008297:Male; D063065:Organophosphonates / Q000008:administration & dosage* / Q000627:therapeutic use; D027383:Papillomaviridae / Q000145:classification / Q000187:drug effects; D016896:Treatment Outcome; D014860:Warts / Q000150:complications / Q000188:drug therapy* / Q000821:virology
D000998:Antiviral Agents; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir