Specific detection of proteins using photonic crystal waveguides.
Specific detection of proteins is demonstrated using planar photonic crystal waveguides. Using immobilized biotin as probe, streptavidin was captured, causing the waveguide mode cut-off to red-shift. The device was shown to detect a 2.5 nm streptavidin film with a 0.86 nm cut-off red-shift. An improved photonic crystal waveguide sensor design is also described and shown to have a 40% improved bulk refractive index response.
Buswell
S C
SC
Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Alberta T6G 2V4, Canada.
Wright
V A
VA
Buriak
J M
JM
Van
V
V
Evoy
S
S
D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D001709:Biotechnology / Q000379:methods; D001710:Biotin / Q000737:chemistry*; D003460:Crystallization; D004867:Equipment Design; D055095:Optics and Photonics; D017785:Photons; D011506:Proteins / Q000032:analysis / Q000737:chemistry*; D012031:Refractometry; D012825:Silicon; D019809:Streptavidin / Q000737:chemistry*
D011506:Proteins; D001710:Biotin; D019809:Streptavidin; D012825:Silicon