Body cooling causes normalization of cardiac protein expression and function in a rat heatstroke model.
Cardiac dysfunction contributes to heatstroke genesis, which can be ameliorated by whole body cooling. A comparative analysis using two-dimensional in-gel electrophoresis of cardiac protein patterns is performed in rat controls, untreated heatstroke rats, and whole body cooling-treated heatstroke rats. After the onset of heatstroke, animals display hypotension and altered cardiac protein profiles, which can be reversed by whole body cooling. Thus, the proteomic mechanisms exerted by body cooling during heatstroke are elucidated by the current results.
Cheng
Bor-Chih
BC
Department of Surgery and Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan.
Chang
Ching-Ping
CP
Tsay
Yeou-Guang
YG
Wu
Ting-Feng
TF
Hsu
Chiung-Yueh
CY
Lin
Mao-Tsun
MT
D000818:Animals; D001831:Body Temperature; D018883:Heat Stroke / Q000209:etiology / Q000503:physiopathology*; D007036:Hypothermia, Induced / Q000379:methods*; D023421:Models, Animal; D009206:Myocardium / Q000378:metabolism*; D020543:Proteome / Q000378:metabolism*; D040901:Proteomics / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley
D020543:Proteome