New organoselenium compounds active against pathogenic bacteria, fungi and viruses.
Different N-substituted benzisoselenazol-3(2H)-ones, analogues of ebselen were designed as new antiviral and antimicrobial agents. We report their synthesis, chemical properties as well as study on biological activity against broad spectrum of pathogenic microorganisms (Staphylococcus aureus, Staphylococcus simulans, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Candida albicans, Aspergillus niger) and viruses (herpes simplex virus type 1 (HSV-1), encephalomyocarditis virus (EMCV), vesicular stomatitis virus (VSV)), in vitro. Most of them exhibited high activity against viruses (HSV-1, EMCV) and gram-positive bacteria strains (S. aureus, S. simulans), while their activity against gram-negative bacteria strains (E. coli, P. aeruginosa, K. pneumoniae) was substantially lower. Some of tested compounds were active against yeast C. albicans and filamentous fungus A. niger.
Pietka-Ottlik
Magdalena
M
Department of Organic Chemistry, Faculty of Chemistry, Wrocław University of Technology, Wroclaw, Poland.
Wójtowicz-Młochowska
Halina
H
Kołodziejczyk
Katarzyna
K
Piasecki
Egbert
E
Młochowski
Jacek
J
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001393:Azoles / Q000138:chemical synthesis / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000494:pharmacology*; D002470:Cell Survival; D005658:Fungi / Q000187:drug effects; D006801:Humans; D007202:Indicators and Reagents; D054833:Isoindoles; D008826:Microbial Sensitivity Tests; D016566:Organoselenium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D014780:Viruses / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000998:Antiviral Agents; D001393:Azoles; D019086:Bridged Bicyclo Compounds, Heterocyclic; D007202:Indicators and Reagents; D054833:Isoindoles; D016566:Organoselenium Compounds; C042986:ebselen