Dietary calcium and vitamin D intakes in childhood and throughout adulthood and mammographic density in a British birth cohort.
We examined the role of dietary calcium and vitamin D intakes in childhood and throughout adulthood in relation to mammographic density using data from a nationally representative cohort of 1161 women followed up since their birth in 1946. Dietary intakes at the age of 4 years were determined by 24-h recalls and at the ages of 36, 43 and 53 years by 5-day food records. After adjusting for known risk factors and confounders, no evidence of a relationship between dietary calcium or vitamin D intakes and mammographic density approximately at the age of 50 years was found, except for a cross-sectional relationship between dietary calcium intake at the age of 53 years and breast density in women who were post-menopausal at the time of mammography, with those in the top fifth of the distribution of calcium intake having a 0.53 s.d. lower percent breast density than those in the lowest fifth (P-value <0.01 for linear trend).
Mishra
G
G
MRC Unit for Lifelong Health and Ageing, Department of Epidemiology and Public Health, University College London, London, UK. g.mishra@nshd.mrc.ac.uk
McCormack
V
V
Kuh
D
D
Hardy
R
R
Stephen
A
A
dos Santos Silva
I
I
D000328:Adult; D002136:Calcium, Dietary / Q000008:administration & dosage*; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D014807:Vitamin D / Q000008:administration & dosage*
D002136:Calcium, Dietary; D014807:Vitamin D