Diversolides A-G, guaianolides from the roots of Ferula diversivittata.
Seven sesquiterpene lactone derivatives, diversolides A-G (1-7), together with two known compounds, diversin (8) and stigmasterol, were isolated from the roots of Ferula diversivittata. The structures of these compounds were elucidated by extensive spectroscopic methods including 1D-(1H and 13C) and 2D-NMR experiments (DQF-COSY, HSQC, HMBC, and NOESY) as well as high-resolution EIMS. Compounds 1, 4 and 6-8 were tested for their in vitro antifungal and antibacterial activities. Some of the tested compounds showed moderate antifungal and antibacterial activities with minimum inhibitory concentration (MIC) values from 40 to 80microg/ml.
Iranshahi
Mehrdad
M
Department of Pharmacognosy and Biotechnology, Biotechnology Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, Vakilabad Boulevard, Mashhad, Iran. iranshahim@mums.ac.ir
Hosseini
Seyyed Tahmineh
ST
Shahverdi
Ahmad Reza
AR
Molazade
Kamyar
K
Khan
Saleha Suleman
SS
Ahmad
Viqar Uddin
VU
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005309:Ferula / Q000737:chemistry*; D005658:Fungi / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D018517:Plant Roots / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D000890:Anti-Infective Agents; D012717:Sesquiterpenes