Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs.
New drugs are needed for treatment of Toxoplasma gondii infections. We tested derivatives of principles found in Isatis indigotica for in vitro efficacy against T. gondii infection. Indirubin-3'-oxime analogs showed modest micromolar activity, while tryptanthrin derivatives displayed 50% inhibitory doses in the low nanomolar range. Tryptanthrins have potential as anti-Toxoplasma infection therapeutics.
Krivogorsky
Bogdana
B
Dept. of Pediatrics, Johns Hopkins University School of Medicine, 600 N. Wolfe St., Baltimore, MD 21287, USA.
Grundt
Peter
P
Yolken
Robert
R
Jones-Brando
Lorraine
L
D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology; D031219:Isatis / Q000737:chemistry*; D021261:Parasitic Sensitivity Tests; D011799:Quinazolines / Q000737:chemistry / Q000494:pharmacology*; D014122:Toxoplasma / Q000187:drug effects* / Q000254:growth & development
D000981:Antiprotozoal Agents; D004365:Drugs, Chinese Herbal; D007211:Indoles; D011799:Quinazolines; C046243:tryptanthrine; C027185:indirubin