title: Polymeric PARACEST agents for enhancing MRI contrast sensitivity.
abstract: Linear polymers of PARACEST agents were prepared by using classical free radical chain polymerization conditions. The Eu3+-polymers exhibited similar intermediate-to-slow water exchange and CEST characteristics as the Eu3+-monomers. This provided an avenue to lower the detection limit of these imaging agents substantially and makes them potentially useful as MRI sensors for molecular imaging.
authors.affiliation: Department of Chemistry, University of Texas at Dallas, P.O. Box 830668, Richardson, Texas 75083, USA.
authors.forename: Yunkou
authors.initials: Y
authors.lastname: Wu
authors.forename: Youfu
authors.initials: Y
authors.lastname: Zhou
authors.forename: Olivier
authors.initials: O
authors.lastname: Ouari
authors.forename: Mark
authors.initials: M
authors.lastname: Woods
authors.forename: Piyu
authors.initials: P
authors.lastname: Zhao
authors.forename: Todd C
authors.initials: TC
authors.lastname: Soesbe
authors.forename: Garry E
authors.initials: GE
authors.lastname: Kiefer
authors.forename: A Dean
authors.initials: AD
authors.lastname: Sherry
mesh_terms: D002614:Chelating Agents / Q000138:chemical synthesis / Q000737:chemistry*; D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry*; D005063:Europium / Q000737:chemistry; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008280:Magnetics; D015394:Molecular Structure; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D012680:Sensitivity and Specificity
chemical_list: D002614:Chelating Agents; D003287:Contrast Media; D011108:Polymers; D005063:Europium