title: Deferasirox treatment improved the hemoglobin level and decreased transfusion requirements in four patients with the myelodysplastic syndrome and primary myelofibrosis.
abstract: Transfusion-induced iron overload is a frequent problem that clinicians have to face in the treatment of patients affected by both myelodysplastic syndrome (MDS) and primary myelofibrosis (PMF). Different options are currently available for chelation therapy, e.g. oral once-daily administration of the iron chelator deferasirox. In 3 patients with MDS and 1 patient with PMF, deferasirox therapy resulted in an improvement in the hemoglobin level and a reduction in transfusion dependence. Our data open new insights regarding the benefit of iron chelation therapy not only for transfusional iron overload of myelodysplastic and myelofibrotic patients but also for the increase in hemoglobin levels. The biological mechanism of action of deferasirox, an effect which is not shared by other iron chelators, is still obscure and requires further investigations.
authors.affiliation: Division of Hematology and Internal Medicine, Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Messa
authors.forename: D
authors.initials: D
authors.lastname: Cilloni
authors.forename: F
authors.initials: F
authors.lastname: Messa
authors.forename: F
authors.initials: F
authors.lastname: Arruga
authors.forename: A
authors.initials: A
authors.lastname: Roetto
authors.forename: G
authors.initials: G
authors.lastname: Saglio
mesh_terms: D000368:Aged; D001565:Benzoates / Q000008:administration & dosage*; D001803:Blood Transfusion; D000077588:Deferasirox; D005260:Female; D006454:Hemoglobins / Q000032:analysis* / Q000187:drug effects; D006801:Humans; D007502:Iron Chelating Agents / Q000627:therapeutic use; D019190:Iron Overload / Q000209:etiology; D008297:Male; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000628:therapy*; D055728:Primary Myelofibrosis / Q000150:complications / Q000628:therapy*; D016896:Treatment Outcome; D014230:Triazoles / Q000008:administration & dosage*
chemical_list: D001565:Benzoates; D006454:Hemoglobins; D007502:Iron Chelating Agents; D014230:Triazoles; D000077588:Deferasirox