Diaryl ether synthesis in supercritical carbon dioxide in batch and continuous flow modes.
A high yielding, batch mode synthesis of diaryl ethers and sulfides by an S(N)Ar fluoride-mediated process in scCO(2) has been developed; the use of a polymer-supported imidazolium fluoride reagent in batch mode led to the development of a fixed-bed continuous flow process, with high conversions.
Lee
Jin-Kyun
JK
Department of Chemistry, University of Cambridge, Cambridge, UK CB2 1EW.
Fuchter
Matthew J
MJ
Williamson
Rachel M
RM
Leeke
Gary A
GA
Bush
Edward J
EJ
McConvey
Ian F
IF
Saubern
Simon
S
Ryan
John H
JH
Holmes
Andrew B
AB
D002245:Carbon Dioxide / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D025924:Chromatography, Supercritical Fluid; D004987:Ethers / Q000138:chemical synthesis* / Q000737:chemistry; D005464:Fluorobenzenes / Q000737:chemistry; D015394:Molecular Structure; D011312:Pressure; D013440:Sulfides / Q000138:chemical synthesis / Q000737:chemistry
D004987:Ethers; D005464:Fluorobenzenes; D013440:Sulfides; D002245:Carbon Dioxide