title: The role of vesicoureteral reflux in acute renal cortical scintigraphic lesion and ultimate scar formation.
abstract: OBJECTIVE
  We assessed whether differences exist in the rates of acute photon defect and scar formation using dimercapto-succinic acid scintigraphy according to the presence and grade of vesicoureteral reflux.
  
  
  METHODS
  A total of 389 patients with a first febrile urinary tract infection were enrolled. For all patients ultrasonography, dimercapto-succinic acid scintigraphy and voiding cystourethrography were performed. Dimercapto-succinic acid scintigraphy was performed within 5 days of and 6 months after diagnosis of urinary tract infection. Voiding cystourethrography was performed after the acute phase of urinary tract infection. The rates of acute photon defect and scar formation on dimercapto-succinic acid scintigraphy according to the presence and grade of vesicoureteral reflux were assessed.
  
  
  RESULTS
  A total of 125 females and 264 males were included in the study. Of the patients 93 had refluxing urinary tract infection and 296 had nonrefluxing infection. The rate of acute photon defect (74.2% vs 32.1%, p = 0.0001) and the rate of ultimate scar change on followup dimercapto-succinic acid scintigraphy were significantly higher in patients with refluxing urinary tract infection (50% vs 18.3%, p = 0.0001). Positive linear association was noted between reflux grade and acute photon defect by linear association test (p = 0.002). No association was found between reflux grade and scar formation (p = 0.262).
  
  
  CONCLUSIONS
  Although vesicoureteral reflux is not a prerequisite for development of acute photon defect and subsequent renal scarring, reflux itself might be an aggravating factor for acute photon defect and scar formation. There seems to be a correlation between reflux grade and frequency of acute photon defect on dimercapto-succinic acid scintigraphy but scar change occurs independently of reflux grade.
authors.affiliation: Department of Urology, Korea University Hospital 80, Seoul, Republic of Korea.
authors.forename: Mi Mi
authors.initials: MM
authors.lastname: Oh
authors.forename: Myeong Heon
authors.initials: MH
authors.lastname: Jin
authors.forename: Jae Hyun
authors.initials: JH
authors.lastname: Bae
authors.forename: Hong Seok
authors.initials: HS
authors.lastname: Park
authors.forename: Jeong Gu
authors.initials: JG
authors.lastname: Lee
authors.forename: Du Geon
authors.initials: du G
authors.lastname: Moon
mesh_terms: D000208:Acute Disease; D017677:Age Distribution; D016009:Chi-Square Distribution; D002675:Child, Preschool; D002921:Cicatrix / Q000000981:diagnostic imaging / Q000473:pathology; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007223:Infant; D007672:Kidney Cortex / Q000000981:diagnostic imaging / Q000473:pathology*; D007674:Kidney Diseases / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology; D008297:Male; D011336:Probability; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D017678:Sex Distribution; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D014552:Urinary Tract Infections / Q000000981:diagnostic imaging* / Q000453:epidemiology; D014563:Urodynamics; D014718:Vesico-Ureteral Reflux / Q000150:complications* / Q000000981:diagnostic imaging
chemical_list: D019783:Technetium Tc 99m Dimercaptosuccinic Acid