Telomeres and telomerase in lung cancer.
Protected telomeres ensure normal chromosomal segregation during mitosis but at the same time can endow genetically abnormal cancer cells with immortality. Telomerase has a pivotal role in telomere protection, both in normal and cancer cells. Understanding the functional interplay between telomere shortening and telomerase expression in cancer cells is of critical importance to elucidating the precise mechanisms by which these cells are able to bypass telomere crisis and become immortal.
Fernandez-Garcia
Ignacio
I
Oncology Division, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
Ortiz-de-Solorzano
Carlos
C
Montuenga
Luis M
LM
D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D019098:Telomerase / Q000502:physiology*; D016615:Telomere / Q000502:physiology*
D019098:Telomerase