title: Arterial pressure changes during the Valsalva maneuver to predict fluid responsiveness in spontaneously breathing patients.
abstract: OBJECTIVE
  To evaluate whether arterial pressure response during a Valsalva maneuver could predict fluid responsiveness in spontaneously breathing patients.
  
  
  METHODS
  Prospective clinical study in a 17-bed multidisciplinary intensive care unit.
  
  
  METHODS
  Thirty patients without mechanical ventilation and equipped with a radial arterial catheter for whom the decision to give fluids was taken due to suspected hypovolemia.
  
  
  METHODS
  A 10-s Valsalva maneuver was performed before and after volume expansion (VE). Patients were classified as responders if stroke volume index (SVi) increased >/=15% after VE.
  
  
  RESULTS
  Pulse pressure changes during the Valsalva maneuver (VPP) were calculated as the difference between maximal pulse pressure during phase 1 and minimal pulse pressure during phase 2 of the Valsalva maneuver divided by the mean of the two values and expressed as a percentage. Valsalva changes in systolic pressure (VSP) were calculated in similar way. SVi changes induced by VE was correlated with baseline values of VPP and VSP (r (2) = 0.71 and r (2) = 0.60; P < 0.0001, respectively), and with VE-induced changes in VPP and VSP (r (2) = 0.56 and r (2) = 0.44; P < 0.0001 and P < 0.001, respectively). A VPP value of 52% and VSP of 30% predicted fluid responsiveness with a sensitivity of 91% and 73% and a specificity of 95 and 90%, respectively.
  
  
  CONCLUSIONS
  Arterial response during the Valsalva maneuver is a feasible tool for predicting fluid responsiveness in patients without mechanical ventilatory support.
authors.affiliation: Servicio de Cuidados Críticos y Urgencias, Unidad de Investigación Experimental, Hospital del SAS Jerez, C/ Circunvalación s/n, 11407, Jerez de la Frontera, Spain. ignaciomonge@gmail.com
authors.forename: Manuel Ignacio
authors.initials: MI
authors.lastname: Monge García
authors.forename: Anselmo
authors.initials: A
authors.lastname: Gil Cano
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Díaz Monrové
mesh_terms: D000368:Aged; D001794:Blood Pressure; D003422:Critical Care; D005260:Female; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives; D020896:Hypovolemia / Q000175:diagnosis*; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D010952:Plasma Substitutes; D011237:Predictive Value of Tests; D012372:ROC Curve; D013318:Stroke Volume; D014636:Valsalva Maneuver / Q000502:physiology*
chemical_list: D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes