title: Development of autoimmune hepatitis type 1 after pulsed methylprednisolone therapy for multiple sclerosis: a case report.
abstract: A 43-year-old woman with multiple sclerosis (MS) was treated with pulsed methylprednisolone and interferon beta at a hospital. Four weeks after initiating treatment, liver dysfunction occurred and she was referred and admitted to our hospital. Clinical and laboratory findings were consistent with and fulfilled the criteria for drug-induced hepatitis, but not for autoimmune hepatitis (AIH). She was successfully treated with corticosteroids. As ataxia developed after 1 year, she was treated with pulsed methylprednisolone for 3 d, then readmitted to our hospital when liver dysfunction occurred. Clinical and laboratory findings led to the diagnosis of AIH. To the best of our knowledge, this is the second case of AIH developed after pulsed methylprednisolone for MS.
authors.affiliation: Department of Internal Medicine II, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, Japan. junior@fmu.ac.jp
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takahashi
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kanno
authors.forename: Yuta
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Natsumi
authors.initials: N
authors.lastname: Sakamoto
authors.forename: Kyoko
authors.initials: K
authors.lastname: Monoe
authors.forename: Hironobu
authors.initials: H
authors.lastname: Saito
authors.forename: Kazumichi
authors.initials: K
authors.lastname: Abe
authors.forename: Junko
authors.initials: J
authors.lastname: Yokokawa
authors.forename: Atsushi
authors.initials: A
authors.lastname: Irisawa
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Ohira
mesh_terms: D000328:Adult; D005260:Female; D019693:Hepatitis, Autoimmune / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D007371:Interferon-gamma / Q000008:administration & dosage; D008775:Methylprednisolone / Q000008:administration & dosage / Q000009:adverse effects*; D009103:Multiple Sclerosis / Q000150:complications / Q000188:drug therapy*; D011994:Recombinant Proteins
chemical_list: D011994:Recombinant Proteins; D007371:Interferon-gamma; D008775:Methylprednisolone