Organocatalytic asymmetric transferhydrogenation of beta-nitroacrylates: accessing beta2-amino acids.
We describe a highly efficient and enantioselective Hantzsch ester mediated conjugate reduction of beta-nitroacrylates that is catalyzed by a Jacobsen thiourea catalyst as a key step in a new route to optically active beta2-amino acids.
Martin
Nolwenn J A
NJ
Max-Planck-Institut für Kohlenforschung, D-45470 Mülheim an der Ruhr, Germany.
Cheng
Xu
X
List
Benjamin
B
D000179:Acrylates / Q000737:chemistry*; D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006865:Hydrogenation; D015394:Molecular Structure; D009574:Nitro Compounds / Q000737:chemistry*; D013237:Stereoisomerism
D000179:Acrylates; D000596:Amino Acids; D009574:Nitro Compounds