title: [Obtaining and study of monosaccharide derivatives of low-molecular-weight chitosan].
abstract: The possibility of obtaining monosaccharide derivatives of low-molecular-weight chitosan with the use of the Maillard reaction was studied. Chitosan derivatives (molecular weight, 24 and 5 kDa) obtained with glucosamine, N-acetyl galactosamine, galactose, and mannose with a substitution degree of 4-14% and a yield of 60-80% were obtained. Some physicochemical and biological properties of these derivatives were studied. We showed that monosaccharide derivatives of low-molecular-weight chitosan exhibited antibacterial activity. Chitosan at a concentration of 0.01% caused 100% death of bacteria B. subtilis and E. coil. The strongest antibacterial effect was exhibited by 24-kDa derivatives: only 0.02-0.08% of cells survived. These derivatives were two orders of magnitude more effective than the 5-kDa chitosan modified with galactose.
authors.forename: A V
authors.initials: AV
authors.lastname: Il'ina
authors.forename: S N
authors.initials: SN
authors.lastname: Kulikov
authors.forename: G I
authors.initials: GI
authors.lastname: Chalenko
authors.forename: N G
authors.initials: NG
authors.lastname: Gerasimova
authors.forename: V P
authors.initials: VP
authors.lastname: Varlamov
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000254:growth & development; D048271:Chitosan / Q000737:chemistry*; D004926:Escherichia coli / Q000254:growth & development; D006601:Hexoses / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D008970:Molecular Weight
chemical_list: D000900:Anti-Bacterial Agents; D006601:Hexoses; D048271:Chitosan