title: In situ gel based on gellan gum as new carrier for nasal administration of mometasone furoate.
abstract: The main purpose of this study was to prepare a novel in situ gel system for nasal delivery of MF and study its efficacy on allergic rhinitis model. An ion-activated in situ gel was developed and characterized with gellan gum as a carrier. The system was stable kept at 40+/-2 degrees C for 6 months, and the micrographic results showed that in situ gel was safety without mucosa irritation when given at 20 microg once daily for 1 month to rats with allergic rhinitis. MF in gellan gum produced obviously effect on allergic rhinitis at the doses of 20 microg/body following intranasal administration, and the efficacy was significantly superior to that of the common suspension (P<0.01). The in situ gel system is a promising approach for the intranasal delivery of MF for the therapeutic effects improvement.
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Fudan University (Fenglin Campus), Shanghai, PR China.
authors.forename: Shi-lei
authors.initials: SL
authors.lastname: Cao
authors.forename: Xiao-wei
authors.initials: XW
authors.lastname: Ren
authors.forename: Qi-zhi
authors.initials: QZ
authors.lastname: Zhang
authors.forename: En
authors.initials: E
authors.lastname: Chen
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.forename: Li-Chun
authors.initials: LC
authors.lastname: Liu
authors.forename: Xin-guo
authors.initials: XG
authors.lastname: Jiang
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D018926:Anti-Allergic Agents / Q000008:administration & dosage* / Q000633:toxicity; D001001:Anura; D004195:Disease Models, Animal; D004337:Drug Carriers / Q000737:chemistry; D004355:Drug Stability; D004356:Drug Storage; D005260:Female; D005782:Gels; D008297:Male; D000068656:Mometasone Furoate; D009297:Nasal Mucosa / Q000187:drug effects / Q000378:metabolism; D011135:Polysaccharides, Bacterial / Q000737:chemistry*; D011244:Pregnadienediols / Q000008:administration & dosage* / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy*; D018675:Toxicity Tests
chemical_list: D018926:Anti-Allergic Agents; D004337:Drug Carriers; D005782:Gels; D011135:Polysaccharides, Bacterial; D011244:Pregnadienediols; D000068656:Mometasone Furoate; C048288:gellan gum