title: Anti-inflammatory activities of furanoditerpenoids and other constituents from Fibraurea tinctoria.
abstract: Five new furanoditerpenoids, epi-8-hydroxycolumbin (1), fibaruretin B (2), C (3), E (5), and F (6), were isolated from the stems of Fibraurea tinctoria, as well as fibaruretin D (4) from the natural source for the first time, and 39 known compounds. The structures (1-6) were elucidated on the basis of spectroscopic analysis. All the isolated furanoditerpenoids (1-16) were examined for their in vitro activity and some were in vivo anti-inflammatory activity. Compounds 8 and 9 showed significant anti-inflammatory action administered at a dose of 100mg/kg of reducing carrageenan mice paw edema, whereas compound 7, 9, 10, 14, and 16 were more potent to inhibit NO production. The inhibitory effects of these compounds are dose-dependent (1-4 microg/ml).
authors.affiliation: Department of Chemistry, National Cheng Kung University, No.1, University Road, Tainan 701, Taiwan.
authors.forename: Chung-Ren
authors.initials: CR
authors.lastname: Su
authors.forename: Yuh-Fung
authors.initials: YF
authors.lastname: Chen
authors.forename: Meei-Jen
authors.initials: MJ
authors.lastname: Liou
authors.forename: Huei-Yann
authors.initials: HY
authors.lastname: Tsai
authors.forename: Wen-Shin
authors.initials: WS
authors.lastname: Chang
authors.forename: Tian-Shung
authors.initials: TS
authors.lastname: Wu
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002478:Cells, Cultured; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D004487:Edema / Q000188:drug therapy*; D008264:Macrophages / Q000187:drug effects; D029583:Menispermaceae / Q000737:chemistry*; D051379:Mice; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D009569:Nitric Oxide