title: Chylopericardium in adults: a literature review over the past decade (1996-2006).
abstract: OBJECTIVE
  We present a systematic overview of the literature on reported cases of chylous pericardial effusion in adults over the past 10 years, assessing clinical presentation, etiology, diagnosis, and treatment.
  
  
  METHODS
  We conducted an evidence-based literature review searching for all reported adult cases of chylopericardium in the past 10 years (January 1996-December 2006).
  
  
  RESULTS
  A total of 33 reported cases of chylopericardium were identified through a systematic literature search. There was no gender bias in the incidence of chylous pericardial effusion. Age at diagnosis varied from 18 to 68 years with a mean +/- standard deviation of 36.78 +/- 14.71 years. Time from symptom onset to diagnosis was variable (ranging from acute presentation to several years). The most common reported etiology was idiopathic. The diagnosis was made by pericardiocentesis in all patients. A search for secondary causes included computed tomography of the chest, lymphoscintigraphy, and lymphangiography along with radioactive oral (131)I-triolein. Conservative therapy was prescribed in 28 patients and failed in 16, in whom subsequent surgery was necessary. Overall, 21 patients underwent various types of surgery. Thoracic duct ligation with creation of a pericardial window was the most common surgical procedure.
  
  
  CONCLUSIONS
  Chylopericardium is a rare entity. The fluid appearance, triglyceride content, cytologic characteristics, and negative cultures are crucial to make the correct diagnosis. Treatment is dependent on the etiology. Surgical management is the most successful. Conservative therapy is reserved for patients with idiopathic chylopericardium, those with an untreatable etiology, those considered at high risk for surgical treatment, or those with a predictably short lifespan.
authors.affiliation: Mayo Clinic College of Medicine, Division of Cardiovascular Diseases and Cardiovascular Surgery, Scottsdale, Ariz, USA.
authors.forename: Chadi
authors.initials: C
authors.lastname: Dib
authors.forename: A Jamil
authors.initials: AJ
authors.lastname: Tajik
authors.forename: Soon
authors.initials: S
authors.lastname: Park
authors.forename: Mohammed E L
authors.initials: ME
authors.lastname: Kheir
authors.forename: Bijoy
authors.initials: B
authors.lastname: Khandieria
authors.forename: Farouk
authors.initials: F
authors.lastname: Mookadam
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010490:Pericardial Effusion / Q000175:diagnosis / Q000209:etiology / Q000601:surgery