title: Point of failure as a predictor of in vitro fertilization treatment discontinuation.
abstract: Among 2,245 women, those who experienced a chemical pregnancy that failed to progress to a clinically recognized pregnancy or a spontaneous abortion on their first IVF cycle were more likely to discontinue IVF treatment than those whose first cycle ended before embryo transfer or who did not have a positive pregnancy test after transfer. However, among women who did continue to a second IVF cycle, those who had at least a chemical pregnancy on the first cycle were more likely to have a live birth on the second attempt than those women who had failed before conception in the first cycle (34% success rate compared with 21%, respectively).
authors.affiliation: Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA.
authors.forename: Kimberly R
authors.initials: KR
authors.lastname: Pearson
authors.forename: Russ
authors.initials: R
authors.lastname: Hauser
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Cramer
authors.forename: Stacey A
authors.initials: SA
authors.lastname: Missmer
mesh_terms: D000328:Adult; D023381:Endpoint Determination; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods* / Q000706:statistics & numerical data*; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D016015:Logistic Models; D008875:Middle Aged; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D012189:Retrospective Studies; D017211:Treatment Failure