The technological transformation of patient-driven human immunology research.
New scientific technologies applied to patients with rare diseases are facilitating discoveries about how the human immune system is regulated at the molecular level. Studies of patients with autoimmune lymphoproliferative syndrome (ALPS) or caspase-8 deficiency state (CEDS) demonstrated the ability of gene expression microarray analyses and small interfering RNAs (siRNA) to establish the physiologically important roles of NRAS, caspase-10, and caspase-8 for normal lymphocyte apoptosis and activation. The advent of genomics technologies such as next generation sequencing will complement these and more traditional approaches. These advances are anticipated to accelerate the pace of new discoveries in patients with immunological disorders.
Su
Helen C
HC
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10CRC, Room 5W3940, 10CRC Center Dr., MSC 1456, Bethesda, MD 20892-1456, USA. hsu@niaid.nih.gov
D000818:Animals; D035843:Biomedical Research / Q000639:trends; D020811:Biomedical Technology / Q000379:methods*; D020869:Gene Expression Profiling / Q000379:methods*; D023281:Genomics / Q000379:methods*; D006801:Humans; D007107:Immune System / Q000276:immunology; D007154:Immune System Diseases / Q000235:genetics / Q000276:immunology* / Q000628:therapy; D020411:Oligonucleotide Array Sequence Analysis; D034741:RNA, Small Interfering / Q000235:genetics; D035583:Rare Diseases / Q000235:genetics / Q000276:immunology* / Q000628:therapy
D034741:RNA, Small Interfering