title: Antinociceptive, antiinflammatory and antipyretic properties of Channa striatus fillet aqueous and lipid-based extracts in rats.
abstract: The present study was carried out to elucidate the antinociceptive, antiinflammatory and antipyretic properties of the aqueous and lipid-based extracts of Channa striatus fillet in rats. The antinociceptive activity was assessed using the formalin test, and the antiinflammatory and antipyretic activities were assessed using the carrageenan-induced paw edema and brewer's yeast-induced pyrexia tests, respectively. Both types of extracts were prepared in concentrations of 10%, 50% and 100% by serial dilution in distilled water or dimethyl sulfoxide, respectively, and were administered subcutaneously 30 min prior to each test. Except for the 10% aqueous extract which exhibits activity only in the early phase, the extracts were found to exhibit significant (P < 0.05) activity in the early and late phases of the formalin test. Furthermore, the aqueous and lipid-based extracts were also found to show significant (P < 0.05) antiinflammatory activity, with the former showing a greater effect at the lowest concentration used. The lipidbased, but not the aqueous, extract was found to have significant (P < 0.05) activity in the pyrexia test. In conclusion, the present study demonstrated that C. striatus extracts possess antinociceptive, antiinflammatory and antipyretic activities.
authors.affiliation: Faculty of Pharmacy, Science and Technology Complex, Universiti Teknologi MARA, Shah Alam, Malaysia. shaza8174@yahoo.com
authors.forename: Z A
authors.initials: ZA
authors.lastname: Zakaria
authors.forename: G Hanan
authors.initials: GH
authors.lastname: Kumar
authors.forename: A M
authors.initials: AM
authors.lastname: Mat Jais
authors.forename: M R
authors.initials: MR
authors.lastname: Sulaiman
authors.forename: M N
authors.initials: MN
authors.lastname: Somchit
mesh_terms: D000596:Amino Acids / Q000032:analysis; D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents; D001241:Aspirin / Q000494:pharmacology; D002351:Carrageenan; D002725:Chloroform; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005227:Fatty Acids / Q000032:analysis; D005399:Fishes / Q000502:physiology*; D005557:Formaldehyde; D007249:Inflammation / Q000139:chemically induced / Q000517:prevention & control; D008055:Lipids / Q000737:chemistry; D008297:Male; D000432:Methanol; D009020:Morphine / Q000494:pharmacology; D018482:Muscle, Skeletal / Q000737:chemistry*; D010147:Pain Measurement / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012441:Saccharomyces cerevisiae; D012997:Solvents; D014020:Tissue Extracts / Q000032:analysis / Q000494:pharmacology*; D014867:Water
chemical_list: D000596:Amino Acids; D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid; D000893:Anti-Inflammatory Agents; D005227:Fatty Acids; D008055:Lipids; D012997:Solvents; D014020:Tissue Extracts; D014867:Water; D005557:Formaldehyde; D009020:Morphine; D002725:Chloroform; D002351:Carrageenan; D001241:Aspirin; D000432:Methanol