title: [Adaptive response--the general biological tendency: facts, hipothesis, questions].
abstract: It is leading up to the proofs testifying about the general-biological nature of adaptive response (AR), which is similar unspecific defense effect: for example, small doses induce cytokines synthesis, providing the resistance to different infectious agents. The connection between AR, DNA-repair, anti-oxidative status, expression of TP53 gene is discussed. The absence of AR at some patients can be explained either individual sensitivity to challenging treatment or criteria of the estimation (chromosome aberration, apoptosis et. al.). These facts are showing that the absence of AR cannot be the indicator of the risk for health. So the idea about general biological existence of AR is postulated because it is a characteristic for different species.
authors.forename: G D
authors.initials: GD
authors.lastname: Zasukhina
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D024201:Bystander Effect; D002470:Cell Survival / Q000528:radiation effects; D016207:Cytokines / Q000502:physiology; D004249:DNA Damage / Q000502:physiology; D004260:DNA Repair; D016158:Genes, p53 / Q000502:physiology; D006801:Humans; D009153:Mutagens / Q000633:toxicity; D011836:Radiation Tolerance; D014780:Viruses; D015032:Zinc / Q000502:physiology
chemical_list: D016207:Cytokines; D009153:Mutagens; D015032:Zinc