title: Human papillomavirus type-distribution in condylomata acuminata of mainland China: a meta-analysis.
abstract: The aim of this work was to study the human papillomavirus (HPV) type-distribution in condylomata acuminata (CA) of mainland China and to estimate the potential role of HPV prophylactic vaccines for CA in mainland China. Forty-three studies using polymerase chain reaction to detect HPV were included in this meta-analysis, and totally 5247 CA cases and 436 controls were included. The overall and type-specific prevalence of HPV 6, 11, 40, 42, 43, 44 were estimated using non-conditional logistic regression model. Overall HPV prevalence was 84.2% and 4.6% for CA and controls, respectively. Estimated HPV types 6, 11, 40, 42 positive fractions in CA were 54.9%, 41.1%, 2.7% and 2.0%, respectively, and exactly 0% for HPV types 43 and 44. HPV 6 and/or 11-positive fractions were 83.0% in mainland China. Thus, prophylactic HPV vaccine has the potential to protect up to 83% of CA cases in mainland China.
authors.affiliation: Department of Cancer Epidemiology, Cancer Institute, Peking Union Medical College, Beijing, China.
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.forename: Y L
authors.initials: YL
authors.lastname: Qiao
mesh_terms: D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003218:Condylomata Acuminata / Q000453:epidemiology* / Q000517:prevention & control / Q000821:virology*; D006801:Humans; D027383:Papillomaviridae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000517:prevention & control / Q000821:virology*; D053918:Papillomavirus Vaccines / Q000008:administration & dosage; D016133:Polymerase Chain Reaction / Q000379:methods; D015995:Prevalence; D013045:Species Specificity; D016896:Treatment Outcome; D014611:Vaccination
chemical_list: D053918:Papillomavirus Vaccines