[Protein kinases in mitochondria].
Mitochondria, besides playing a central role in energy metabolism within the cell, are involved in a cohort of other processes like cellular differentiation and apoptosis. Investigations during recent few years have shown that protein kinases, including PKA, PKB/Akt, PKC, Raf-1, p38 MAPK, JNK, ERK1/2, Src, Fyn and Csk, may directly interact with mitochondrial proteins. Their role mainly concentrates at phosphorylation of pro- and anti-apoptotic proteins (Bad, Bax, Bcl-2, Bcl-xL), phosphorylation/modification of electron transport chain proteins (complex I, COIV), MPTP forming proteins VDAC and ANT, proteins of mitochondrial ATP-sensitive potassium channel (mitoK(ATP)) and phospholipid scramblase 3 (PLSCR3). Many experimental data showed the presence of protein kinases in the outer and inner mitochondrial membranes as well as in the mitochondrial matrix during in vitro cell stimulations, in neurodegenerative diseases and in in vivo ischaemia heart preconditioning. These data show that translocation of protein kinases to mitochondria plays an important role especially during ischaemia/reperfusion in brain and heart.
Kowalczyk
Joanna Ewa
JE
Pracownia Biologii Molekularnej, Instytut Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego PAN, Warszawa. jkowalczyk@cmdik.pan.pl
Zabłocka
Barbara
B
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D006801:Humans; D051336:Mitochondrial Membranes / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000378:metabolism*; D017202:Myocardial Ischemia / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism*; D021381:Protein Transport
D024101:Mitochondrial Proteins; D011494:Protein Kinases