Acute kidney injury after transarterial chemoembolization for hepatocellular carcinoma: a retrospective analysis.
BACKGROUND
Transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) may result in acute kidney injury (AKI) like other angiographic interventions.


METHODS
To investigate the incidence, risk factor and outcomes of AKI after TACE, defined by Acute Kidney Injury Network (AKIN) criteria, we retrospectively analyzed 442 TACE treatment sessions in 236 HCC patients.


RESULTS
The incidence of AKI in the first 48 h after TACE was 9.8% (23 of 236 patients at risk). Presence of hypertension (OR 3.24, 95% CI 1.21-8.72, p = 0.02), lower baseline serum albumin (OR 0.29, 95% CI 0.15-0.56, p < 0.01) and higher creatinine level (OR 12.02, 95% CI 3.49-41.39, p < 0.01) were independent risk factors of AKI. Prolonged renal insufficiency after 1 month was observed in 24.1% of AKI episodes.


CONCLUSIONS
AKI is a common complication after TACE and we have to pay attention to the prevention and early recognition of AKI occurrence in high-risk patients.
Park
Jongha
J
Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
Chung
Hyun Chul
HC
Lee
Jong Soo
JS
Lee
Byeong Man
BM
Kim
Dong Min
DM
Hwang
Jae Cheol
JC
Jo
Min-Woo
MW
Noh
Maengseok
M
Shin
Jung Woo
JW
D000208:Acute Disease; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D016461:Chemoembolization, Therapeutic / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D015994:Incidence; D007668:Kidney / Q000293:injuries* / Q000503:physiopathology; D007674:Kidney Diseases / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012709:Serum Albumin / Q000032:analysis
D012709:Serum Albumin; D003404:Creatinine