Tedanolide and the evolution of polyketide inhibitors of eukaryotic protein synthesis.
This Highlight covers the chemical and biological studies regarding a set of polyketide inhibitors of eukaryotic protein synthesis related to the marine-derived cytotoxic agent tedanolide.
Taylor
Richard E
RE
Department of Chemistry & Biochemistry and the Walther Cancer Research Center, University of Notre Dame, Notre Dame, IN 46556-5670, USA. taylor.61@nd.edu
D000818:Animals; D005075:Biological Evolution; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D008387:Marine Toxins / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D048630:Polyketide Synthases / Q000378:metabolism*; D011161:Porifera / Q000737:chemistry*; D014176:Protein Biosynthesis / Q000187:drug effects*
D018942:Macrolides; D008387:Marine Toxins; D048630:Polyketide Synthases; C119775:tedanolide