title: Molecular surveillance for multidrug-resistant Plasmodium falciparum, Cambodia.
abstract: We conducted surveillance for multidrug-resistant Plasmodium falciparum in Cambodia during 2004-2006 by assessing molecular changes in pfmdr1. The high prevalence of isolates with multiple pfmdr1 copies found in western Cambodia near the Thai border, where artesunate-mefloquine therapy failures occur, contrasts with isolates from eastern Cambodia, where this combination therapy remains highly effective.
authors.affiliation: University of North Carolina School of Public Health, Chapel Hill, North Carolina, USA.
authors.forename: Naman K
authors.initials: NK
authors.lastname: Shah
authors.forename: Alisa P
authors.initials: AP
authors.lastname: Alker
authors.forename: Rithy
authors.initials: R
authors.lastname: Sem
authors.forename: Agustina Ika
authors.initials: AI
authors.lastname: Susanti
authors.forename: Sinuon
authors.initials: S
authors.lastname: Muth
authors.forename: Jason D
authors.initials: JD
authors.lastname: Maguire
authors.forename: Socheat
authors.initials: S
authors.lastname: Duong
authors.forename: Frederic
authors.initials: F
authors.lastname: Ariey
authors.forename: Steven R
authors.initials: SR
authors.lastname: Meshnick
authors.forename: Chansuda
authors.initials: C
authors.lastname: Wongsrichanalai
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage; D037621:Artemisinins / Q000008:administration & dosage; D000077332:Artesunate; D002160:Cambodia / Q000453:epidemiology; D018432:Drug Resistance, Multiple / Q000235:genetics; D005260:Female; D018628:Gene Dosage; D017125:Genes, Protozoan; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000453:epidemiology* / Q000469:parasitology*; D008297:Male; D015767:Mefloquine / Q000008:administration & dosage; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000235:genetics; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D011159:Population Surveillance; D015800:Protozoan Proteins / Q000235:genetics
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D000077332:Artesunate; D015767:Mefloquine; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D015800:Protozoan Proteins; C513498:Mdr1 protein, Plasmodium falciparum