title: An improved protocol for the Pd-catalyzed alpha-arylation of aldehydes with aryl halides.
abstract: An improved protocol for the Pd-catalyzed alpha-arylation of aldehydes with aryl halides has been developed. The new catalytic system allows for the coupling of an array of substrates including challenging electron-rich aryl bromides and less reactive aryl chlorides. The utility of this method has been demonstrated in a new total synthesis of (+/-)-sporochnol.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Rubén
authors.initials: R
authors.lastname: Martín
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Buchwald
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis* / Q000737:chemistry; D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D006219:Halogens / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D010636:Phenols / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000447:Aldehydes; D000475:Alkenes; D006219:Halogens; D010636:Phenols; D010165:Palladium