Molecular surveillance for multidrug-resistant Plasmodium falciparum, Cambodia.
We conducted surveillance for multidrug-resistant Plasmodium falciparum in Cambodia during 2004-2006 by assessing molecular changes in pfmdr1. The high prevalence of isolates with multiple pfmdr1 copies found in western Cambodia near the Thai border, where artesunate-mefloquine therapy failures occur, contrasts with isolates from eastern Cambodia, where this combination therapy remains highly effective.
Shah
Naman K
NK
University of North Carolina School of Public Health, Chapel Hill, North Carolina, USA.
Alker
Alisa P
AP
Sem
Rithy
R
Susanti
Agustina Ika
AI
Muth
Sinuon
S
Maguire
Jason D
JD
Duong
Socheat
S
Ariey
Frederic
F
Meshnick
Steven R
SR
Wongsrichanalai
Chansuda
C
D000293:Adolescent; D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage; D037621:Artemisinins / Q000008:administration & dosage; D000077332:Artesunate; D002160:Cambodia / Q000453:epidemiology; D018432:Drug Resistance, Multiple / Q000235:genetics; D005260:Female; D018628:Gene Dosage; D017125:Genes, Protozoan; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000453:epidemiology* / Q000469:parasitology*; D008297:Male; D015767:Mefloquine / Q000008:administration & dosage; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000235:genetics; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D011159:Population Surveillance; D015800:Protozoan Proteins / Q000235:genetics
D000962:Antimalarials; D037621:Artemisinins; D000077332:Artesunate; D015767:Mefloquine; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D015800:Protozoan Proteins; C513498:Mdr1 protein, Plasmodium falciparum