Structure elucidation and 1H/13C NMR spectral assignments of four trabectedin related compounds.
This article presents the structure elucidation of four new compounds, formed during the hemisynthetic preparation of trabectedin, an anti-tumor natural product from Ecteinascidia turbinata. We report herein on the use of UV, MS and NMR spectroscopic data along with (1)H and (13)C spectral assignments obtained by means of 1D and 2D homo- and heteronuclear NMR techniques.
Vermeulen
Wim
W
Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium. wvermeu2@its.jnj.com
Filliers
Walter
W
García
Carmen
C
Manzanaro
Sonia
S
Montalvo
David
D
Polanco
Concepción
C
Spillemaeckers
Frank
F
Van Hoof
Bart
B
Winderickx
Guido
G
Somers
Ivan
I
Rodriguez-Campos
Ignacio
I
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry; D002247:Carbon Isotopes; D004149:Dioxoles / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D013058:Mass Spectrometry; D015394:Molecular Structure; D013056:Spectrophotometry, Ultraviolet; D044005:Tetrahydroisoquinolines / Q000737:chemistry*; D000077606:Trabectedin; D014561:Urochordata / Q000737:chemistry
D000970:Antineoplastic Agents; D002247:Carbon Isotopes; D004149:Dioxoles; D044005:Tetrahydroisoquinolines; D000077606:Trabectedin