Hydrogenation of hindered ketones catalyzed by a silica-supported compact phosphine-Rh system.
A heterogeneous mono(phosphine)-Rh catalyst system silica-SMAP-Rh(OMe)(cod), where silica-SMAP stands for a caged, compact trialkylphosphine (SMAP) supported on silica gel, showed broad applicability toward the hydrogenation of hindered ketones. Doubly alpha-branched ketones such as diisopropyl ketone was hydrogenated under nearly atmospheric conditions. Di-tert-butyl ketone could be hydrogenated under more forcing conditions.
Kawamorita
Soichiro
S
Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan.
Hamasaka
Go
G
Ohmiya
Hirohisa
H
Hara
Kenji
K
Fukuoka
Atsushi
A
Sawamura
Masaya
M