title: sICAM-1 intrathecal synthesis and release during the acute phase in children suffering from Coxsackie A9 and S. pneumoniae meningoencephalitis.
abstract: The intercellular adhesion molecule is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Serum and cerebrospinal fluid (CSF) soluble intercellular adhesion molecule 1 (sICAM-1) from normal control children as well as from children with Guillain-Barré syndrome (GBS), with Coxsackie A9 virus meningoencephalitis and with Streptococcus pneumoniae meningoencephalitis were studied. sICAM-1 was quantified using an immunoenzimatic assay and albumin using the immunodiffusion technique in both biological fluids. Increased sICAM-1 values in CSF in patients with GBS correspond to an increase of the albumin CSF/serum quotient. In contrast, in inflammatory diseases like S. pneumoniae and Coxsackie A9 virus meningoencephalitis an increased brain-derived fraction was observed. In particular cases these values are 60-65% and 70-75% respectively. The results indicate an additional synthesis of sICAM-1 in subarachnoidal space during central nervous system (CNS) inflammatory process. An important role of sICAM-1 in the transmigration of different cell types into CSF during CNS inflammation in children with S. pneumoniae and Coxsackie A9 meningoencephalitis may be suggested.
authors.affiliation: Laboratorio Central de Líquido Cefalorraquídeo, Facultad de Ciencias Médicas Dr. Miguel Enríquez, Ciudad Habana, Cuba. adorta@infomed.sld.cu
authors.forename: Alberto J
authors.initials: AJ
authors.lastname: Dorta-Contreras
authors.forename: Piotr
authors.initials: P
authors.lastname: Lewczuk
authors.forename: Bárbara
authors.initials: B
authors.lastname: Padilla-Docal
authors.forename: Elena
authors.initials: E
authors.lastname: Noris-García
authors.forename: Raisa Bu
authors.initials: RB
authors.lastname: Coifiu-Fanego
authors.forename: Consuelo
authors.initials: C
authors.lastname: Sánchez-Martínez
authors.forename: Alexis
authors.initials: A
authors.lastname: Rodríguez-Rey
authors.forename: Marlén
authors.initials: M
authors.lastname: González-Hernández
mesh_terms: D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D001812:Blood-Brain Barrier / Q000502:physiology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003384:Coxsackievirus Infections / Q000134:cerebrospinal fluid* / Q000276:immunology; D029822:Enterovirus B, Human; D004797:Enzyme-Linked Immunosorbent Assay; D020275:Guillain-Barre Syndrome / Q000134:cerebrospinal fluid* / Q000276:immunology; D006801:Humans; D005779:Immunodiffusion; D007132:Immunoglobulin Isotypes / Q000096:biosynthesis / Q000134:cerebrospinal fluid; D007249:Inflammation / Q000097:blood / Q000134:cerebrospinal fluid; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis / Q000134:cerebrospinal fluid*; D008297:Male; D008590:Meningoencephalitis / Q000134:cerebrospinal fluid* / Q000276:immunology / Q000382:microbiology; D011008:Pneumococcal Infections / Q000134:cerebrospinal fluid* / Q000276:immunology / Q000382:microbiology; D012709:Serum Albumin / Q000134:cerebrospinal fluid
chemical_list: D015415:Biomarkers; D007132:Immunoglobulin Isotypes; D012709:Serum Albumin; D018799:Intercellular Adhesion Molecule-1