Phosphoproteomics, oncogenic signaling and cancer research.
The past 5 years have seen an explosion of phosphoproteomics methods development. In this review, using epidermal growth-factor signaling as a model, we will discuss how phosphoproteomics, along with bioinformatics and computational modeling, have impacted key aspects of oncogenic signaling such as in the temporal fine mapping of phosphorylation events, and the identification of novel tyrosine kinase substrates and phosphorylation sites. We submit that the next decade will see considerable exploitation of phosphoproteomics in cancer research. Such a phenomenon is already happening as exemplified by its use in promoting the understanding of the molecular etiology of cancer and target-directed therapeutics.
Chong
Poh-Kuan
PK
Oncology Research Institute, Yong Loo Lin School of Medicine, Singapore.
Lee
Huiyin
H
Kong
Jacklyn Wai-Fun
JW
Loh
Marie Chiew-Shia
MC
Wong
Chee-Hong
CH
Lim
Yoon-Pin
YP
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D019295:Computational Biology; D003198:Computer Simulation; D004815:Epidermal Growth Factor / Q000235:genetics / Q000502:physiology; D066246:ErbB Receptors / Q000235:genetics / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D009857:Oncogenes / Q000502:physiology*; D010750:Phosphoproteins / Q000502:physiology*; D010766:Phosphorylation; D040901:Proteomics / Q000379:methods*; D015398:Signal Transduction
D010750:Phosphoproteins; D004815:Epidermal Growth Factor; D066246:ErbB Receptors