title: Hepcidin and iron status among pregnant women in Bangladesh.
abstract: Although hepcidin, a recently discovered peptide hormone, is considered a major regulator of iron metabolism and anemia in chronic inflammation, its role in anemia during pregnancy has not been characterized. Our objective was to characterize the role of hepcidin in anemia during pregnancy. We examined the relationships between urinary hepcidin, iron status indicators, hemoglobin, erythropoietin, alpha-1 acid glycoprotein, and C-reactive protein in a cross-sectional study conducted among 149 pregnant rural Bangladeshi women with biospecimens obtained during home visits. Urinary hepcidin was measured using surface-enhanced laser desorption/ ionization time-of-flight mass spectrometry. Urinary hepcidin, as log(intensity per mmol/L creatinine), was correlated with log ferritin (r = 0.33, p <0.001), the transferrin receptor index (r = -0.22, p = 0.007), and log alpha-1 acid glycoprotein (r = 0.20, p = 0.01), but not hemoglobin (r = 0.07, p= 0.40), log transferrin receptor (r = -0.07, p = 0.41), log erythropoietin (r = -0.01, p = 0.88) or log C-reactive protein (r = 0.06, p = 0.48). The strength of the relationship between hepcidin and ferritin was maintained in multiple linear regression analyses after enhancing the sample with data from women selected for low iron stores (n = 41). Among pregnant women in a community-based study in rural Bangladesh, urinary hepcidin levels were related to iron status and AGP but not hemoglobin, erythropoietin, or C-reactive protein.
authors.affiliation: Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. kschulze@jhsph.edu
authors.forename: Kerry J
authors.initials: KJ
authors.lastname: Schulze
authors.forename: Parul
authors.initials: P
authors.lastname: Christian
authors.forename: Ingo
authors.initials: I
authors.lastname: Ruczinski
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Ray
authors.forename: Avindra
authors.initials: A
authors.lastname: Nath
authors.forename: Lee S-F
authors.initials: LS
authors.lastname: Wu
authors.forename: Richard D
authors.initials: RD
authors.lastname: Semba
mesh_terms: D000293:Adolescent; D000328:Adult; D000740:Anemia / Q000378:metabolism / Q000652:urine; D018798:Anemia, Iron-Deficiency / Q000453:epidemiology / Q000378:metabolism / Q000652:urine*; D023181:Antimicrobial Cationic Peptides / Q000652:urine*; D001459:Bangladesh; D015415:Biomarkers / Q000378:metabolism / Q000652:urine; D003430:Cross-Sectional Studies; D004921:Erythropoietin; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D064451:Hepcidins; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000652:urine; D007501:Iron / Q000378:metabolism*; D016014:Linear Models; D009752:Nutritional Status; D011247:Pregnancy / Q000652:urine*; D011248:Pregnancy Complications / Q000453:epidemiology / Q000378:metabolism / Q000652:urine; D055815:Young Adult
chemical_list: D023181:Antimicrobial Cationic Peptides; D015415:Biomarkers; C578702:HAMP protein, human; D006454:Hemoglobins; D064451:Hepcidins; D004921:Erythropoietin; D007501:Iron