title: Stimulated intrauterine insemination (SIUI) and donor insemination (DI) as first line management for a selected subfertile population: the Manchester experience.
abstract: OBJECTIVE
  The objective of our study is to investigate the optimum number of stimulated intrauterine insemination (SIUI) or donor insemination (DI) cycles that can be offered to the couples prior to in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) in a tertiary referral unit for assisted reproduction.
  
  
  METHODS
  This is a retrospective analysis of 408 SIUI and 704 DI cycles performed in a tertiary referral unit for assisted reproduction. SIUI's were performed by controlled ovarian hyperstimulation and ovulation induction followed by insemination 36 h later. DI's were performed in natural or stimulated cycles after thawing frozen donor sperm. The main outcome measured was cumulative live birth rate (CLBR) per couple.
  
  
  RESULTS
  A maximum CLBR of 26.1% was achieved after the fourth cycle of SIUI. The CLBR of DI increased to 60.1% in the sixth cycle.
  
  
  CONCLUSIONS
  This study, in line with a number of other studies, is unable to demonstrate unequivocally whether increasing numbers of IUI or DI cycles are justified clinically or financially. There is a need for larger datasets from multiple centres along with rigorous randomised trials to compare treatment pathways. Until then, the resources spent on the provision of extra SIUI cycles may be better utilized by early referral to IVF.
authors.affiliation: Department of Reproductive Medicine, Saint Mary's Hospital, Whitworth Park, Manchester M13 0JH, UK.
authors.forename: S
authors.initials: S
authors.lastname: Vitthala
authors.forename: T A
authors.initials: TA
authors.lastname: Gelbaya
authors.forename: H
authors.initials: H
authors.lastname: Hunter
authors.forename: S A
authors.initials: SA
authors.lastname: Roberts
authors.forename: L G
authors.initials: LG
authors.lastname: Nardo
mesh_terms: D000328:Adult; D005260:Female; D005307:Fertilization in Vitro / Q000187:drug effects*; D006062:Gonadotropins / Q000627:therapeutic use; D006801:Humans; D007316:Insemination, Artificial, Heterologous / Q000379:methods*; D007317:Insemination, Artificial, Homologous / Q000379:methods*; D008297:Male; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods
chemical_list: D006062:Gonadotropins