title: Is leptin a significant predictor of bone mineral density in postmenopausal Turkish women?
abstract: The objective of the present study was to investigate the relationship between leptin and bone mineral density in postmenopausal Turkish women. A total of 122 healthy postmenopausal women were enrolled in this cross-sectional study. Blood samples were obtained for analysis of serum leptin. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry at the lumbar spine, femoral neck and trochanter on the same day. Leptin levels was significantly correlated with BMD of L(1-4) (P = 0.04), but not of femoral neck (P = 0.13), and trochanter (P = 0.39). However, Z scores of L(1-4) (P = 0.009), femur neck (P = 0.009), and femur trochanter (P = 0.025) were positively correlated with leptin levels. In multiple linear regression analysis, leptin was not found to be a statistically significant independent predictor for BMD. Leptin was associated with BMD and Z scores at various body sites; however, it was not an independent predictor of BMD.
authors.affiliation: Department of Obstetrics and Gynecology, Dr. Zekai Tahir Burak Woman Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Oguz
authors.forename: Omer L
authors.initials: OL
authors.lastname: Tapisiz
authors.forename: Hakan
authors.initials: H
authors.lastname: Aytan
authors.forename: Ilker
authors.initials: I
authors.lastname: Gunyeli
authors.forename: Savas
authors.initials: S
authors.lastname: Erdem
authors.forename: Gorkem
authors.initials: G
authors.lastname: Tuncay
authors.forename: Umit
authors.initials: U
authors.lastname: Bilge
authors.forename: Leyla
authors.initials: L
authors.lastname: Mollamahmutoglu
mesh_terms: D015502:Absorptiometry, Photon; D015519:Bone Density; D003430:Cross-Sectional Studies; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging; D005272:Femur Neck / Q000000981:diagnostic imaging; D006801:Humans; D020738:Leptin / Q000097:blood*; D016014:Linear Models; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D017698:Postmenopause / Q000097:blood*; D011237:Predictive Value of Tests; D012044:Regression Analysis; D014421:Turkey
chemical_list: D020738:Leptin