title: Synthesis of new 1-[2-Azido-2-(2,4-dichlorophenyl)ethyl]-1H/-imidazoles and in vitro evaluation of their antifungal activity.
abstract: New 1-[2-azido-2-(2,4-dichlorophenyl)ethyl]-1H/-imidazole were synthesized by nucleophilic substitution of various tertiary alcohols with azide anion in presence of boron trifluoride-diethyl etherate. Their antifungal activity was evaluated against Candida albicans, Candida glabrata, Aspergillus fumigatus and an azole-resistant petite mutant of C. glabrata. Preliminary SAR results are discussed.
authors.affiliation: EA 921, Laboratoire SONAS, UFR des Sciences Pharmaceutiques et Ingenierie de la Sante, Angers, France.
authors.forename: Francis
authors.initials: F
authors.lastname: Chevreuil
authors.forename: Anne
authors.initials: A
authors.lastname: Landreau
authors.forename: Denis
authors.initials: D
authors.lastname: Seraphin
authors.forename: Gérald
authors.initials: G
authors.lastname: Larcher
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Bouchara
authors.forename: Pascal
authors.initials: P
authors.lastname: Richomme
mesh_terms: D000438:Alcohols; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000187:drug effects; D001386:Azides; D002176:Candida albicans / Q000187:drug effects; D041221:Candida glabrata / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000438:Alcohols; D000935:Antifungal Agents; D001386:Azides; D007093:Imidazoles