title: Does creatine supplementation improve the plasma lipid profile in healthy male subjects undergoing aerobic training?
abstract: We aimed to investigate the effects of creatine (Cr) supplementation on the plasma lipid profile in sedentary male subjects undergoing aerobic training.
  
  
  METHODS
  Subjects (n = 22) were randomly divided into two groups and were allocated to receive treatment with either creatine monohydrate (CR) (~20 g.day-1 for one week followed by ~10 g.day-1 for a further eleven weeks) or placebo (PL) (dextrose) in a double blind fashion. All subjects undertook moderate intensity aerobic training during three 40-minute sessions per week, over 3 months. High-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), very low-density lipoprotein cholesterol (VLDL), total cholesterol (TC), triglyceride (TAG), fasting insulin and fasting glycemia were analyzed in plasma. Thereafter, the homeostasis model assessment (HOMA) was calculated. Tests were performed at baseline (Pre) and after four (Post 4), eight (Post 8) and twelve (Post 12) weeks.
  
  
  RESULTS
  We observed main time effects in both groups for HDL (Post 4 versus Post 8; P = 0.01), TAG and VLDL (Pre versus Post 4 and Post 8; P = 0.02 and P = 0.01, respectively). However, no between group differences were noted in HDL, LDL, CT, VLDL and TAG. Additionally, fasting insulin, fasting glycemia and HOMA did not change significantly.
  
  
  CONCLUSIONS
  These findings suggest that Cr supplementation does not exert any additional effect on the improvement in the plasma lipid profile than aerobic training alone.
authors.affiliation: Laboratory of Applied Nutrition and Metabolism, School of Physical Education and Sport, University of São Paulo, Brazil. gualano@usp.br.
authors.forename: Bruno
authors.initials: B
authors.lastname: Gualano
authors.forename: Carlos
authors.initials: C
authors.lastname: Ugrinowitsch
authors.forename: Guilherme G
authors.initials: GG
authors.lastname: Artioli
authors.forename: Fabiana B
authors.initials: FB
authors.lastname: Benatti
authors.forename: Fernanda B
authors.initials: FB
authors.lastname: Scagliusi
authors.forename: Roger C
authors.initials: RC
authors.lastname: Harris
authors.forename: Antonio H
authors.initials: AH
authors.lastname: Lancha