Ratio of lethal and edema factors in rabbit systemic anthrax.
Bacillus anthracis secretes two binary toxins: lethal toxin (PA + LF) and edema toxin (PA + EF) that play a major role in the pathogenesis of anthrax. Their activities can synergize or interfere among each other, depending on the cell type. It is therefore fundamental to know their concentration ratio in vivo. Here, we report the first determination of the concentration ratio of anthrax toxin components LF/EF in the serum of rabbits infected with B. anthracis spores.
Molin
Federica Dal
FD
Dipartimento di Scienze Biomediche- CNR Istituto di Neuroscienze, viale G. Colombo 3, 35121 Padova, Italy.
Fasanella
Antonio
A
Simonato
Morena
M
Garofolo
Giuliano
G
Montecucco
Cesare
C
Tonello
Fiorella
F
D000818:Animals; D000881:Anthrax / Q000382:microbiology*; D000942:Antigens, Bacterial / Q000097:blood* / Q000633:toxicity; D001408:Bacillus anthracis / Q000472:pathogenicity; D001427:Bacterial Toxins / Q000097:blood* / Q000633:toxicity; D015153:Blotting, Western; D016014:Linear Models; D011817:Rabbits
D000942:Antigens, Bacterial; D001427:Bacterial Toxins; C030325:anthrax toxin