Molecular domains of myelinated axons in the peripheral nervous system.
Myelinated axons are organized into a series of specialized domains with distinct molecular compositions and functions. These domains, which include the node of Ranvier, the flanking paranodal junctions, the juxtaparanodes, and the internode, form as the result of interactions with myelinating Schwann cells. This domain organization is essential for action potential propagation by saltatory conduction and for the overall function and integrity of the axon.
Salzer
James L
JL
Department of Cell Biology and Neurology, and the Smilow Neuroscience Program, NYU School of Medicine, New York, New York 10016.
Brophy
Peter J
PJ
Centre for Neuroscience Research, University of Edinburgh, Edinburgh EH9 1QH, United Kingdom.
Peles
Elior
E
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001369:Axons / Q000502:physiology / Q000648:ultrastructure; D003599:Cytoskeleton / Q000378:metabolism; D006801:Humans; D009413:Nerve Fibers, Myelinated / Q000502:physiology* / Q000648:ultrastructure; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009431:Neural Conduction / Q000502:physiology; D017933:Peripheral Nervous System / Q000166:cytology / Q000502:physiology*; D011901:Ranvier's Nodes / Q000502:physiology / Q000648:ultrastructure; D012583:Schwann Cells / Q000502:physiology* / Q000648:ultrastructure
D009419:Nerve Tissue Proteins