Molecular markers of heavy metal toxicity--a new paradigm for health risk assessment.
Last decade has witnessed increased interest in studies dealing with molecular markers of health and disease expression of genes. Specific toxicant "signatures" have been detected using genome base technologies such as microarrays. Further toxins have been classified on the basis of these signatures. Knowledge on these signatures has helped in the identification of novel drug candidates. This review discusses the gene expression studies recently made on arsenic, cadmium, mercury, chromium, lead, copper, nickel, manganese, and other essential elements. Toxicogenomics standards and their organizations have also been briefly described. Although this information can not be considered as complete, recent reports from different laboratories on bacteria, fish, laboratory animals and humans have been summarized. It is expected that toxicogenomics data presented in this review will be helpful in planning and excretion of human health risk assessment programs.
Yoon
Seokjoo
S
Korea Institute of Toxicology, 100 Jangdong, Yuseong, Daejeon-305 343, Republic of Korea. sokjoo@empal.com
Han
Sang Seop
SS
Rana
S V S
SV
D000818:Animals; D004784:Environmental Monitoring / Q000379:methods* / Q000592:standards; D004785:Environmental Pollutants / Q000633:toxicity*; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D019216:Metals, Heavy / Q000633:toxicity*; D011634:Public Health; D018570:Risk Assessment; D043922:Toxicogenetics
D004785:Environmental Pollutants; D005819:Genetic Markers; D019216:Metals, Heavy