title: Occupation/industry and risk of non-Hodgkin's lymphoma in the United States.
abstract: OBJECTIVE
  To identify occupations and industries associated with non-Hodgkin's lymphoma (NHL) in a large population-based, case-control study in the USA.
  
  
  METHODS
  Cases (n = 1189) of histologically confirmed malignant NHL ages 20-74 were prospectively identified in four geographic areas covered by the National Cancer Institute SEER Program. Controls (n = 982) were selected from the general population by random digit dialling (<65 years of age) and from residents listed in Medicare files (65-74 years of age). Odds ratios and 95% confidence intervals for occupations and industries were calculated by unconditional logistic regression analyses, adjusting for age, gender, ethnicity and study centre. Further analyses stratified for gender and histological subtype were also performed.
  
  
  RESULTS
  Risk of NHL was increased for a few occupations and industries. Several white collar occupations, with no obvious hazardous exposures, had elevated risks, including purchasing agents and buyers, religious workers, physical therapists and information clerks. Occupations with excesses that may have exposures of interest include launderers and ironers, service occupations, food/beverage preparation supervisors, hand packers and packagers, roofing and siding, leather and leather products, transportation by air, nursing and personal care facilities, and specialty outpatient clinics. Significantly decreased risks of NHL were found for a number of occupations and industries including post-secondary teachers and chemical and allied products.
  
  
  CONCLUSIONS
  The results of this study suggest that several occupations and industries may alter the risk of NHL. Our results support previously reported increased risks among farmers, printers, medical professionals, electronic workers and leather workers. These findings should be evaluated further in larger studies that have the power to focus on specific exposures and histological subtypes of NHL.
authors.affiliation: Department of Family Medicine and Public Health Sciences, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA. mschenk@med.wayne.edu
authors.forename: M
authors.initials: M
authors.lastname: Schenk
authors.forename: M P
authors.initials: MP
authors.lastname: Purdue
authors.forename: J S
authors.initials: JS
authors.lastname: Colt
authors.forename: P
authors.initials: P
authors.lastname: Hartge
authors.forename: A
authors.initials: A
authors.lastname: Blair
authors.forename: P
authors.initials: P
authors.lastname: Stewart
authors.forename: J R
authors.initials: JR
authors.lastname: Cerhan
authors.forename: A J
authors.initials: AJ
authors.lastname: De Roos
authors.forename: W
authors.initials: W
authors.lastname: Cozen
authors.forename: R K
authors.initials: RK
authors.lastname: Severson
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007221:Industry; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000453:epidemiology / Q000209:etiology*; D009790:Occupations; D012307:Risk Factors; D012737:Sex Factors; D014481:United States / Q000453:epidemiology; D055815:Young Adult