[Influence of cattle cord blood fraction below 5 kD on biochemical parameters of blood in experimental chronic stomach ulcer in rats].
Influence of cattle cord blood fraction (below 5 kD) on lipid peroxidation product content and alkaline phosphatase activity-in peripheral blood was studied on the experimental subchronic stomach ulcer model in rats. It has been shown that the fraction administrations normalize thiobarbituric-active product content and alkaline phosphatase activity in blood, which testifies to decreasing inflammatory reaction in the mucous membrane of the stomach. The fraction administrations accelerate the processes of regeneration of the mucous membrane of the stomach up to complete healing of ulcer defects. Cord blood fraction below 5 kD from cattle possesses antiulcer activity which is analogous to the actovegin activity. It has been shown by gel-penetrating chromatography that the pattern of cord blood fraction low molecular substances is different from the actovegin pattern both qualitatively and quantitatively.
Gulevskiĭ
A K
AK
Abakumova
E S
ES
Moiseeva
N N
NN
Dolgikh
O L
OL
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D000897:Anti-Ulcer Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D002417:Cattle; D002850:Chromatography, Gel; D004195:Disease Models, Animal; D005312:Fetal Blood / Q000737:chemistry*; D006418:Heme / Q000031:analogs & derivatives / Q000627:therapeutic use; D008297:Male; D008970:Molecular Weight; D051381:Rats; D013276:Stomach Ulcer / Q000097:blood* / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
D000897:Anti-Ulcer Agents; D017392:Thiobarbituric Acid Reactive Substances; D006418:Heme; C015646:Actovegin; D000469:Alkaline Phosphatase