Preeclampsia and subsequent risk of cancer: update from the Jerusalem Perinatal Study.
OBJECTIVE
The purpose of this study was to examine the association between preeclampsia and cancer incidence.


METHODS
The Jerusalem Perinatal Study is a population-based cohort of all births to 41,206 residents of Western Jerusalem from 1964-76. Cancer incidence to 2004 was assessed by linkage of the cohort with the Israel Cancer Registry. Cox's proportional hazards models were constructed to estimate the hazard ratio for cancer among women who had had preeclampsia.


RESULTS
Preeclampsia was associated with a 1.23-fold increased risk of cancer at all sites, a 37% increased risk of breast cancer, and more than a doubling of ovarian cancer risk. Analysis by morphologic condition yielded significantly increased risks for malignancies that were classed as cystic mucinous and serous (relative risk, 1.96; 95% CI, 1.00-3.83) and for ductal, lobular, and medullary carcinomas (relative risk, 1.40; 95% CI, 1.07-1.83). No differential association was observed by sex of offspring.


CONCLUSIONS
Our study suggests that the previously described protective effect of preeclampsia on cancer is not universal.
Calderon-Margalit
Ronit
R
Hebrew University-Hadassah Braun School of Public Health, Jerusalem, Israel. ronitcm@ekmd.huji.ac.il
Friedlander
Yechiel
Y
Yanetz
Rivka
R
Deutsch
Lisa
L
Perrin
Mary C
MC
Kleinhaus
Karine
K
Tiram
Efrat
E
Harlap
Susan
S
Paltiel
Ora
O
D001943:Breast Neoplasms / Q000453:epidemiology* / Q000209:etiology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D007557:Israel / Q000453:epidemiology; D008297:Male; D010051:Ovarian Neoplasms / Q000453:epidemiology* / Q000209:etiology; D011225:Pre-Eclampsia / Q000453:epidemiology*; D011247:Pregnancy; D016016:Proportional Hazards Models; D012189:Retrospective Studies