title: Statin use and the risk of Parkinson disease: a nested case control study.
abstract: Using the British Columbia Linked Health Databases, we explored the association between the use of statin drugs and the risk of developing Parkinson disease (PD). We followed a cohort of older adults in the Province of British Columbia from 1997 to 2003. Using a study design of nested case control (case-control study within a cohort), the relative risk of developing PD for statin users was 0.94 (0.82-1.09). Our study did not show a statistically significant effect on the risk of PD with statin use.
authors.affiliation: Department of Neurology, University of Washington, Seattle VA Parkinson Disease Research Education and Clinical Center (PADRECC), VA Puget Sound Health Care System, 1660 S. Columbian Way, MS-127, Seattle, WA 98108, USA. asamii@u.washington.edu
authors.forename: Ali
authors.initials: A
authors.lastname: Samii
authors.forename: Bruce C
authors.initials: BC
authors.lastname: Carleton
authors.forename: Mahyar
authors.initials: M
authors.lastname: Etminan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D015331:Cohort Studies; D016206:Databases, Bibliographic / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D012189:Retrospective Studies; D012306:Risk
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors