Capnellenes from the soft coral Dendronephthya rubeola.
Four new acetoxycapnellenes 1-4, the first epoxyprecapnellene 5, along with the known dihydroxycapnellene 6 and monoacetoxycapnellene 7, have been isolated from the soft coral Dendronephthya rubeola. The structures were determined primarily by NMR spectroscopy. The compounds 6 and 7 showed a good antiproliferative activity against the cell line L-929 (murine fibroblasts) and a good cytotoxic activity against the HeLa (human cervix carcinoma) cell line. Compound 6 strongly inhibits the interaction of the oncogenic transcription factor Myc with its partner protein Max. Myc/Max-Interaction inhibitors are therapeutically interesting compounds in oncology.
Grote
Daniela
D
Lehrstuhl für Organische Chemie, NW II, Universität Bayreuth, D-95440 Bayreuth.
Hänel
Frank
F
Dahse
Hans-Martin
HM
Seifert
Karlheinz
K
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D047028:Macrocyclic Compounds / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D021241:Spectrometry, Mass, Electrospray Ionization
D047028:Macrocyclic Compounds