title: Occurrence of metabolic osteopathy in patients with chronic pancreatitis.
abstract: BACKGROUND
  Chronic pancreatitis is an inflammatory disease manifested by maldigestion and, in an advanced stage, by malabsorption. The aim of our research was to monitor the occurrence of metabolic osteopathies (osteopenia, osteoporosis and osteomalacia) in patients with chronic pancreatitis.
  
  
  METHODS
  The group consisted of 73 patients (17 women and 56 men) in different stages of chronic pancreatitis. In all patients we determined serum concentrations of Ca, P, 25-OH vitamin D, 1,25-(OH)(2) vitamin D, alkaline phosphatase and its bone isoenzyme. Bone mineral density was measured by dual-energy X-ray absorptiometry (DXA) in the lumbar spine (L(1)-L(4)) and in the proximal femur. When bone pathology was identified by DXA, we determined the other to exclude other causes of secondary osteopathy and the 24-hour loss of calcium and phosphorus in the urine.
  
  
  RESULTS
  Osteopathy was found in 39% of patients, i.e. osteopenia in 26%, osteoporosis in 5% and osteomalacia in 8% of cases.
  
  
  CONCLUSIONS
  The occurrence of relatively high percentages of metabolic osteopathies in patients with chronic pancreatitis may correlate, namely in advanced stages of the disease, with the malabsorption of vitamin D to the enterohepatic circulation. In initial forms of pancreatitis, it is not possible to exclude progression of osteopathy due to changes of the intestinal flora, with disturbance of vitamin D absorption to the intestinal mucosa.
authors.affiliation: Department of Internal Medicine and Hepatogastroenterology, University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic. 39822@mail.muni.cz
authors.forename: H
authors.initials: H
authors.lastname: Dujsikova
authors.forename: P
authors.initials: P
authors.lastname: Dite
authors.forename: J
authors.initials: J
authors.lastname: Tomandl
authors.forename: A
authors.initials: A
authors.lastname: Sevcikova
authors.forename: M
authors.initials: M
authors.lastname: Precechtelova
mesh_terms: D001851:Bone Diseases, Metabolic / Q000209:etiology*; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000172:deficiency; D008297:Male; D050500:Pancreatitis, Chronic / Q000150:complications*; D014808:Vitamin D Deficiency / Q000209:etiology*
chemical_list: D006887:Hydroxycholecalciferols