Interleukin-10 promotes Mycobacterium tuberculosis disease progression in CBA/J mice.
IL-10 is a potent immunomodulatory cytokine that affects innate and acquired immune responses. The immunological consequences of IL-10 production during pulmonary tuberculosis (TB) are currently unknown, although IL-10 has been implicated in reactivation TB in humans and with TB disease in mice. Using Mycobacterium tuberculosis-susceptible CBA/J mice, we show that blocking the action of IL-10 in vivo during chronic infection stabilized the pulmonary bacterial load and improved survival. Furthermore, this beneficial outcome was highly associated with the recruitment of T cells to the lungs and enhanced T cell IFN-gamma production. Our results indicate that IL-10 promotes TB disease progression. These findings have important diagnostic and/or therapeutic implications for the prevention of reactivation TB in humans.
Beamer
Gillian L
GL
Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA.
Flaherty
David K
DK
Assogba
Barnabe D
BD
Stromberg
Paul
P
Gonzalez-Juarrero
Mercedes
M
de Waal Malefyt
Rene
R
Vesosky
Bridget
B
Turner
Joanne
J
D000818:Animals; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology*; D016753:Interleukin-10 / Q000276:immunology*; D008168:Lung / Q000276:immunology* / Q000382:microbiology; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000276:immunology* / Q000517:prevention & control
D016753:Interleukin-10; D007371:Interferon-gamma