title: Successful treatment of idiopathic orbital inflammation with infliximab: an alternative to conventional steroid-sparing agents.
abstract: Therapy for orbital pseudotumor, also called idiopathic orbital inflammation, is nonspecific and mainly based on the use of corticosteroids. Two patients with steroid-dependent idiopathic orbital inflammation, one with myositis and the other with dacryoadenitis, and intolerant of standard steroid sparing agents (methotrexate or azathioprine), were treated with infliximab, a monoclonal antitumor necrosis factor alpha antibody. In both patients, orbital manifestations disappeared following treatment. After follow-up for at least 20 months, the 2 patients still receiving infliximab remained event free. Infliximab enabled steroid tapering to less than 5 mg per day, suggesting that infliximab could constitute an alternative to conventional steroid sparing agents.
authors.affiliation: AP-HP (Assistance Publique-Hôpitaux de Paris), Service de Médecine Interne, Hôpital Avicenne, Bobigny, France.
authors.forename: Tiphaine
authors.initials: T
authors.lastname: Miquel
authors.forename: Sébastien
authors.initials: S
authors.lastname: Abad
authors.forename: Isabelle
authors.initials: I
authors.lastname: Badelon
authors.forename: Catherine
authors.initials: C
authors.lastname: Vignal
authors.forename: Ursula
authors.initials: U
authors.lastname: Warzocha
authors.forename: Claire
authors.initials: C
authors.lastname: Larroche
authors.forename: Serge
authors.initials: S
authors.lastname: Morax
authors.forename: Robin
authors.initials: R
authors.lastname: Dhote
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D003607:Dacryocystitis / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D000069285:Infliximab; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016727:Orbital Pseudotumor / Q000175:diagnosis / Q000188:drug therapy*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
chemical_list: D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D005938:Glucocorticoids; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab