Dynamic selection of novel vancomycin N-terminal derivatives by resin-bound reversed D-Ala-D-Ala.
The most attractive advantage of dynamic combinatorial chemistry (DCC) is that it can screen the compound library as soon as compounds are synthesized. However, it is very difficult to analyze a dynamic combinatorial library with free probes using the state-of-the art analysis technologies. We report herein a method that uses a resin-immobilizing reversed peptide probe to screen vancomycin derivatives and provides a solution to this problem.
Chen
Yu-Yan
YY
Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Materia Medica, 2 Nanwei Road, Xuanwu District, Beijing 100050, P. R. China.
He
Wen-Yi
WY
Wu
Yan
Y
Niu
Chang-Qun
CQ
Liu
Gang
G
D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D004151:Dipeptides / Q000737:chemistry*; D055808:Drug Discovery / Q000379:methods*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D012117:Resins, Synthetic; D054852:Small Molecule Libraries; D014640:Vancomycin / Q000031:analogs & derivatives*
D004151:Dipeptides; D012117:Resins, Synthetic; D054852:Small Molecule Libraries; C002956:alanylalanine; D014640:Vancomycin