title: Increased p50 gating but intact prepulse inhibition in borderline personality disorder.
abstract: The authors explore sensory gating deficits in borderline personality disorder patients, such as those described in schizophrenia, in patients with borderline personality disorder. Gating of the P50, N100, and P200 auditory evoked potentials and prepulse inhibition of the startle response (PPI) were measured in borderline patients and a group of healthy comparison subjects. Borderline patients did not show lower sensory gating, but showed higher P50, N100, and P200 gating than comparison subjects. This was mainly due to the increased response after the first stimulus. There were no group differences in PPI. Unlike in other major psychiatric disorders, such as schizophrenia, sensory (motor) gating is intact in borderline personality disorder. The higher early preattentive and mid-latency evoked potentials suggest a higher response tendency in borderline personality disorder, but this needs further replication.
authors.affiliation: CW2 Hospital Nijmegen, Department of Psychiatry (A15), P.O. Box 9015, 6500 GS Nijmegen, The Netherlands. k.Grootens@psy.umcn.nl
authors.forename: Koen P
authors.initials: KP
authors.lastname: Grootens
authors.forename: Gilles
authors.initials: G
authors.lastname: van Luijtelaar
authors.forename: Christopher A F J
authors.initials: CA
authors.lastname: Miller
authors.forename: Tim
authors.initials: T
authors.lastname: Smits
authors.forename: Jacobus W
authors.initials: JW
authors.lastname: Hummelen
authors.forename: Jan K
authors.initials: JK
authors.lastname: Buitelaar
authors.forename: Robbert J
authors.initials: RJ
authors.lastname: Verkes
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001883:Borderline Personality Disorder / Q000473:pathology / Q000503:physiopathology* / Q000523:psychology*; D002540:Cerebral Cortex / Q000503:physiopathology; D004569:Electroencephalography / Q000379:methods; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D011930:Reaction Time / Q000502:physiology; D013216:Reflex, Startle / Q000502:physiology; D055139:Sensory Gating / Q000502:physiology*; D055815:Young Adult