title: [Effective pain relief facilitates exercise therapy : Results of a multicenter study with controlled-release oxycodone in patients with movement pain].
abstract: BACKGROUND
  The efficacy and tolerability of oral controlled-release oxycodone in the therapy of musculoskeletal pain were analyzed in this observational study.
  
  
  METHODS
  A total of 843 patients with severe to most severe pain in the musculoskeletal system were treated with controlled-released oxycodone for 4 weeks or up to a maximum of 6 months. Severity of pain, impairment in quality of life, and mobility associated with the pain were assessed before and during therapy with controlled-release oxycodone by a numerical rating scale (NRS 0-10).
  
  
  RESULTS
  Pain intensity fell by an average of 65% within the first 4 weeks. Physical therapy was practicable in many patients only after implementation of a therapy regime with controlled-release oxycodone. Quality of life improved significantly under therapy with oxycodone, and the impairment of different aspects of life decreased by 50%.
  
  
  CONCLUSIONS
  The therapy of pain of the musculoskeletal system with controlled-release oxycodone is efficient. An effective pain relief makes physical therapy practicable, reduces the impairment in different parts of life, and increases quality of life.
authors.affiliation: St. Josef-Hospital, Orthopädische Universitätsklinik, Gudrunstrasse 56, 44791, Bochum, Deutschland. w.teske@klinikum-bochum.de
authors.forename: W
authors.initials: W
authors.lastname: Teske
authors.forename: A
authors.initials: A
authors.lastname: Anastasiadis
authors.forename: J
authors.initials: J
authors.lastname: Krämer
authors.forename: T
authors.initials: T
authors.lastname: Theodoridis
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000009:adverse effects; D019299:Decompression, Surgical / Q000534:rehabilitation; D003692:Delayed-Action Preparations; D017586:Diskectomy / Q000534:rehabilitation; D004305:Dose-Response Relationship, Drug; D005500:Follow-Up Studies; D005598:Fractures, Spontaneous / Q000534:rehabilitation*; D006801:Humans; D010003:Osteoarthritis / Q000534:rehabilitation*; D055013:Osteoarthritis, Spine / Q000534:rehabilitation*; D010024:Osteoporosis / Q000534:rehabilitation*; D010098:Oxycodone / Q000008:administration & dosage* / Q000009:adverse effects; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy; D026741:Physical Therapy Modalities; D016103:Spinal Fractures / Q000534:rehabilitation*; D013123:Spinal Fusion / Q000534:rehabilitation; D013130:Spinal Stenosis / Q000534:rehabilitation*
chemical_list: D000701:Analgesics, Opioid; D003692:Delayed-Action Preparations; D010098:Oxycodone