title: Differential effects of acute alcohol on prepulse inhibition and event-related potentials in adolescent and adult Wistar rats.
abstract: BACKGROUND
  Previous studies have demonstrated that adolescent and adult rats show differential sensitivity to many of the acute effects of alcohol. We recently reported evidence of developmental differences in the effects of acute alcohol on the cortical electroencephalogram. However, it is unclear whether developmental differences are also observed in other neurophysiological and neurobehavioral measurements known to be sensitive to alcohol exposure. The present study determined the age-related effects of acute alcohol on behavioral and event-related potential (ERP) responses to acoustic startle (AS) and prepulse inhibition (PPI).
  
  
  METHODS
  Male adolescent and adult Wistar rats were implanted with cortical recording electrodes. The effects of acute alcohol (0.0, 0.75, and 1.5 g/kg) on behavioral and ERP responses to AS and PPI were assessed.
  
  
  RESULTS
  Acute alcohol (0.75 and 1.5 g/kg) significantly reduced the behavioral and electrophysiological response to AS in adolescent and adult rats. Both 0.75 and 1.5 g/kg alcohol significantly enhanced the behavioral response to PPI in adolescent, but not in adult rats. During prepulse + pulse trials, 1.5 g/kg alcohol significantly increased the N10 pulse response in the adolescent frontal cortex. Acute alcohol (0.75 and 1.5 g/kg) also increased the N1 ERP pulse response to prepulse stimuli in frontal and parietal cortices in adult rats, but not in adolescent rats.
  
  
  CONCLUSIONS
  These data suggest that alcohol's effect on behavioral and electrophysiological indices of AS do not differ between adults and adolescents whereas developmental stage does appear to significantly modify alcohol-influenced response to PPI.
authors.affiliation: Scripps Research Institute, Department of Molecular and Integrative Neurosciences, La Jolla, California 92037, USA.
authors.forename: Jerry P
authors.initials: JP
authors.lastname: Pian
authors.forename: Jose R
authors.initials: JR
authors.lastname: Criado
authors.forename: Cindy L
authors.initials: CL
authors.lastname: Ehlers
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000367:Age Factors; D000818:Animals; D004195:Disease Models, Animal; D004569:Electroencephalography / Q000187:drug effects / Q000379:methods; D000431:Ethanol / Q000506:poisoning*; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D005072:Evoked Potentials, Auditory / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009415:Nerve Net / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013216:Reflex, Startle / Q000187:drug effects* / Q000502:physiology
chemical_list: D000431:Ethanol