title: Ventricular fibrillation in a 5-year-old child on therapeutic dose of quinine dihydrochloride infusion for acute malaria.
abstract: Malaria is no doubt a disease of public health significance in the tropics. Plasmodium falciparum resistant to majority of the first-line antimalarial drugs now causes most of the infections treated in sub-Saharan Africa. Although there is increasing use of artemisinin-based combination therapy in many African nations, quinine still remains a commonly used drug for severe and chloroquine-resistant malaria. Cardiotoxicity associated with quinine has been largely reported. However, this was often more common with toxic doses. This case report is on a 5-year-old African Nigerian who was on treatment for uncomplicated malaria with quinine dihydrochloride infusion. All the laboratory investigations done were within normal limits except for positive blood films for malarial parasites. However, pre-treatment electrocardiographic evaluation of the patient was not carried out. She developed ventricular fibrillation and died less than one and a half hour into the quinine infusion.
authors.affiliation: Department of Medicine, Federal Medical Centre, PMB 201, Ido-Ekiti, Nigeria. olubusari@yahoo.com
authors.forename: Olusegun
authors.initials: O
authors.lastname: Busari
authors.forename: Olusogo
authors.initials: O
authors.lastname: Busari
mesh_terms: D000962:Antimalarials / Q000008:administration & dosage* / Q000009:adverse effects*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D016778:Malaria, Falciparum / Q000188:drug therapy*; D011803:Quinine / Q000008:administration & dosage* / Q000009:adverse effects*; D014693:Ventricular Fibrillation / Q000139:chemically induced*
chemical_list: D000962:Antimalarials; D011803:Quinine