title: The FTO gene and obesity in a large Eastern European population sample: the HAPIEE study.
abstract: Variants in the FTO (oxoglutarate-dependent nucleic acid demethylase) gene have been associated with the BMI determination in Western European and North American populations. To widen the geographical coverage of the FTO studies, we have analyzed the association between the FTO gene variant rs17817449 (G>C) and obesity in a Slavic Eastern European population. A total of 3,079 males and 3,602 females 45-69 years old were randomly selected from population registers of seven Czech cities. We examined three indices of obesity: BMI (kg/m(2)), waist circumference, and waist-to-hip ratio (WHR). The FTO rs17817449 variant was significantly associated with BMI both in males (GG 28.7 +/- 4.1; GT 28.3 +/- 3.9; TT 28.0 +/- 3.9; P = 0.003) and females (GG 28.7 +/- 5.2; GT 28.2 +/- 5.1; TT 27.2 +/- 4.9; P < 0.001); the associations were not affected by adjustment for age, smoking, socioeconomic status, and physical activity. The FTO variant was also associated with waist circumference (difference between GG and TT was 1.1 cm (P = 0.043) in men and 2.4 cm (P < 0.001) in women) but this relationship disappeared after adjustment for BMI. Similarly, BMI explained the weak association of FTO with WHR and C-reactive protein. FTO was not associated with plasma total and high-density lipoprotein cholesterol, triglycerides, blood glucose, and blood pressure. These results confirm that in a Slavic population the FTO variant is strongly associated with BMI but not with other risk factors.
authors.affiliation: Laboratory of Atherosclerosis Research, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
authors.forename: Jaroslav A
authors.initials: JA
authors.lastname: Hubacek
authors.forename: Romana
authors.initials: R
authors.lastname: Bohuslavova
authors.forename: Lada
authors.initials: L
authors.lastname: Kuthanova
authors.forename: Ruzena
authors.initials: R
authors.lastname: Kubinova
authors.forename: Anne
authors.initials: A
authors.lastname: Peasey
authors.forename: Hynek
authors.initials: H
authors.lastname: Pikhart
authors.forename: Michael G
authors.initials: MG
authors.lastname: Marmot
authors.forename: Martin
authors.initials: M
authors.lastname: Bobak
mesh_terms: D000368:Aged; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D018153:Czech Republic; D003920:Diabetes Mellitus / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000208:ethnology / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D055105:Waist Circumference; D049629:Waist-Hip Ratio
chemical_list: D011506:Proteins; D002097:C-Reactive Protein; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human