Does AMP-activated protein kinase negatively mediate aged fast-twitch skeletal muscle mass?
The activity of 5'-adenosine monophosphate (AMP)-activated protein kinase (AMPK), a negative regulator of cell size, is up-regulated with age in resting and overloaded fast-twitch skeletal muscle but not slow-twitch muscle. Here, we provide evidence to support the hypothesis that elevated AMPK activity plays a potentially important integrative role in the age-related atrophy and diminished capacity for growth specific to fast-twitch skeletal muscle.
Gordon
Scott E
SE
Human Performance Laboratory, 363 Ward Sports Medicine Building, East Carolina University, Greenville, NC 27858, USA. gordonsc@ecu.edu
Lake
Jordan A
JA
Westerkamp
Christopher M
CM
Thomson
David M
DM
D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D000375:Aging; D049108:Cell Enlargement; D006801:Humans; D018656:Muscle Fibers, Fast-Twitch / Q000378:metabolism* / Q000502:physiology; D018482:Muscle, Skeletal / Q000502:physiology*; D009133:Muscular Atrophy / Q000378:metabolism / Q000503:physiopathology
D055372:AMP-Activated Protein Kinases