Application of ghrelin to gastrointestinal diseases.
This review outlines recent findings related to the therapeutic potential of ghrelin agonists or antagonists for the treatment of gastrointestinal (GI) motility disorders and the regulation of the hypothalamic control of feeding. The ability of ghrelin to promote GI motility in patients with postoperative ileus or gastroparesis, and to restore the normal feeding pattern and energy balance in the elderly and in cancer patients with impaired appetite are highlighted. A critical analysis of the possible mechanism of action and the potential benefits of using synthetic ghrelin agonists is based on data from preclinical research and recent clinical studies.
Venkova
Kalina
K
University of Oklahoma Health Sciences Center, Department of Physiology, Veterans Affairs Medical Center, Research Administration Room 151, 921 NE 13th Street, Oklahoma City, OK 73104, USA.
Greenwood-Van Meerveld
Beverley
B
D000375:Aging / Q000502:physiology; D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects; D001066:Appetite / Q000502:physiology; D004415:Dyspepsia / Q000139:chemically induced / Q000188:drug therapy; D004435:Eating / Q000502:physiology; D005767:Gastrointestinal Diseases / Q000188:drug therapy*; D005769:Gastrointestinal Motility / Q000502:physiology; D018589:Gastroparesis / Q000188:drug therapy; D054439:Ghrelin / Q000502:physiology / Q000627:therapeutic use*; D006801:Humans
D000970:Antineoplastic Agents; D054439:Ghrelin