title: An experimental evaluation of the lactate concentration following mesenteric ischemia.
abstract: OBJECTIVE
  Although a diagnosis of mesenteric necrosis can easily be made, mesenteric ischemia is sometimes overlooked, especially in the acute phase. We experimentally evaluated the time course of the lactate concentration, which may be a possibly useful variable in making a diagnosis of mesenteric ischemia, and determined how an early diagnosis can be made.
  
  
  METHODS
  The superior mesenteric artery (SMA) was surgically ligated in an anesthetized pig. Blood tests, including a blood gas analysis, were done using samples from the superior mesenteric vein (SMV), hepatic vein, femoral vein, and artery until 6 h after SMA ligation.
  
  
  RESULTS
  There were no variables in any samples that showed a significant change within 4 h after SMA ligation except for samples taken from the SMV. All acidosis-related variables had changed significantly within 6 h after ischemia. Among them, the lactate concentration only in the SMV was observed to have increased significantly within one hour after SMA ligation.
  
  
  CONCLUSIONS
  Currently available peripheral blood tests, including tests using blood obtained from the hepatic vein, do not enable the detection of mesenteric ischemia within 4 h after onset. In a case in which an exploratory laparotomy is performed, the measurement of the lactate concentration in SMV is thus considered to be a useful supplementary test for making a prompt diagnosis of mesenteric ischemia in an early phase.
authors.affiliation: Department of Traumatology and Critical Care Medicine, Sapporo Medical University, South 1 West 16, Chuo-ku, Sapporo, 060-8543, Japan.
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Kurimoto
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Kawaharada
authors.forename: Toshiro
authors.initials: T
authors.lastname: Ito
authors.forename: Masayuki
authors.initials: M
authors.lastname: Morikawa
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Higami
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Asai
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001784:Blood Gas Analysis; D007511:Ischemia / Q000097:blood*; D019344:Lactic Acid / Q000097:blood*; D008026:Ligation; D017538:Mesenteric Artery, Superior; D008641:Mesenteric Vascular Occlusion / Q000097:blood*; D013552:Swine
chemical_list: D019344:Lactic Acid