Reduction of peritoneal adhesion to polypropylene mesh with the application of fibrin glue.
OBJECTIVE
The purpose of our study was to evaluate the possibility of the reduction of peritoneal adhesions to a polypropylene mesh with fibrin glue.


METHODS
Forty Wistar rats were assigned to two treatment groups: Group 1) hernioplasty with polypropylene mesh plus fibrin glue sealant, and Group 2) hernioplasty with polypropylene mesh without fibrin glue sealant. The variables evaluated were: presence and density of adhesion, organs or abdominal structures adhered to the polypropylene mesh, inflammatory tissular reaction and cell recount.


RESULTS
Group 1 presented a statistically lower adhesion percentage than Group 2 (40% versus 100%, P = 0.0003). The mean areas of mesh patch surfaces covered with adhesions were statistically different between Groups 1 and 2 (0.67 +/- 0.65 cm2 versus 1.60 +/- 0.51 cm2; P = 0.00001). Twelve rats presented with adhesions in Group 1; eleven were adhesions to the epiploon and one to the colon. In Group 2 there were 16 adhesions to the epiploon, 2 to the colon, 1 to the small intestine and 1 to the stomach. Tissular reaction comparison showed a significant difference (21 +/- 4.9 versus 17 +/- 4.1; P = 0.006).


CONCLUSIONS
Fibrin glue sealant significantly reduced the frequency and severity of intra-abdominal adhesions.
Prieto-Díaz-Chávez
E
E
Departamento de Cirugía y Unidad de Investigación en Epidemiología Clínica Hospital General Zona y Medicina Familiar No. 1, Instituto Mexicano del Seguro Social, Colima, México.
Medina-Chávez
J Luis
JL
Ramírez-Barba
E J
EJ
Trujillo-Hernández
B
B
Millán-Guerrero
R O
RO
Vásquez
C
C
D000818:Animals; D004195:Disease Models, Animal; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D046449:Hernia, Abdominal / Q000601:surgery*; D010537:Peritoneum / Q000601:surgery*; D011126:Polypropylenes; D011183:Postoperative Complications / Q000517:prevention & control; D051381:Rats; D017208:Rats, Wistar; D013526:Surgical Mesh; D000267:Tissue Adhesions / Q000517:prevention & control*; D014014:Tissue Adhesives / Q000627:therapeutic use*; D016896:Treatment Outcome
D015718:Fibrin Tissue Adhesive; D011126:Polypropylenes; D014014:Tissue Adhesives