title: Specific detection of proteins using photonic crystal waveguides.
abstract: Specific detection of proteins is demonstrated using planar photonic crystal waveguides. Using immobilized biotin as probe, streptavidin was captured, causing the waveguide mode cut-off to red-shift. The device was shown to detect a 2.5 nm streptavidin film with a 0.86 nm cut-off red-shift. An improved photonic crystal waveguide sensor design is also described and shown to have a 40% improved bulk refractive index response.
authors.affiliation: Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Alberta T6G 2V4, Canada.
authors.forename: S C
authors.initials: SC
authors.lastname: Buswell
authors.forename: V A
authors.initials: VA
authors.lastname: Wright
authors.forename: J M
authors.initials: JM
authors.lastname: Buriak
authors.forename: V
authors.initials: V
authors.lastname: Van
authors.forename: S
authors.initials: S
authors.lastname: Evoy
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D001709:Biotechnology / Q000379:methods; D001710:Biotin / Q000737:chemistry*; D003460:Crystallization; D004867:Equipment Design; D055095:Optics and Photonics; D017785:Photons; D011506:Proteins / Q000032:analysis / Q000737:chemistry*; D012031:Refractometry; D012825:Silicon; D019809:Streptavidin / Q000737:chemistry*
chemical_list: D011506:Proteins; D001710:Biotin; D019809:Streptavidin; D012825:Silicon