A therapeutic dose of zolpidem has limited abuse-like effects in drug-naïve females: a pilot study.
Zolpidem has abuse potential, particularly among individuals with histories of drug abuse. This double-blind, placebo-controlled, cross over pilot study investigated the subjective effects of zolpidem (10 mg) in drug-naïve females. Over the course of a 5-h period vital signs were monitored and a series of computerized questionnaires was administered. Results indicate that zolpidem engendered subjective effects characteristic of hypnotic drugs, but reduced ratings of drug liking, willing to take again, and willing to pay for, relative to placebo. Thus, a therapeutic dose of zolpidem may have limited potential for misuse among females who have no experience with drugs of abuse.
Licata
Stephanie C
SC
Behavioral Psychopharmacology Research Laboratory, McLean Hospital/Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA. slicata@mclean.harvard.edu
Penetar
David M
DM
Dunlap
Steven
S
Lukas
Scott E
SE
D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002746:Chlorpromazine / Q000494:pharmacology; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D010424:Pentobarbital / Q000494:pharmacology; D010865:Pilot Projects; D011725:Pyridines / Q000494:pharmacology*; D012881:Skin Temperature / Q000187:drug effects; D019966:Substance-Related Disorders / Q000523:psychology*; D055815:Young Adult; D000077334:Zolpidem
D014150:Antipsychotic Agents; D006993:Hypnotics and Sedatives; D011725:Pyridines; D000077334:Zolpidem; D010424:Pentobarbital; D002746:Chlorpromazine