A case of lymphangioleiomyomatosis with membranous nephropathy and likely systemic lupus.
Membranous glomerulonephritis is most often idiopathic, but it can be secondary to systemic lupus erythematosus, viral hepatitis, and drugs. A number of malignancies have also been associated with membranous glomerulonephritis, although a causal link has not been established yet. A young patient with lymphangioleiomyomatosis is described who developed massive proteinuria and was found to have membranous glomerulonephritis on renal biopsy. There were many pathological features and some clinical features that suggested the patient also suffered from systemic lupus erythematosus.
Sam
Ramin
R
Division of Nephrology, San Francisco General Hospital, 1001 Potrero Ave, Building 100, Rm 349, San Francisco, CA, 94110-1341, USA. samr@medsfgh.ucsf.edu.|Division of Nephrology, The University of California, San Francisco, CA, USA. samr@medsfgh.ucsf.edu.
Khalid
Samra
S
Department of Medicine, Stroger Hospital of Cook County, Chicago, IL, 60612, USA.
Brecklin
Carolyn
C
Division of Nephrology, Stroger Hospital of Cook County, Chicago, IL, 60612, USA.|Section of Nephrology, University of Illinois at Chicago, Chicago, IL, 60612, USA.
Schwartz
Melvin
M
Division of Pathology, Rush Medical College, Chicago, IL, 60612, USA.
Dunea
George
G
Division of Nephrology, Stroger Hospital of Cook County, Chicago, IL, 60612, USA.|Hektoen Institute of Medicine, Chicago, IL, 60612, USA.
D000328:Adult; D001706:Biopsy; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000150:complications* / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology; D008175:Lung Neoplasms / Q000150:complications*; D008180:Lupus Erythematosus, Systemic / Q000150:complications; D018192:Lymphangioleiomyomatosis / Q000150:complications*; D011507:Proteinuria / Q000150:complications* / Q000473:pathology