Chronic myeloid leukemia following chemotherapy with 5'-deoxy-5-fluorouridine for gastric cancer.
We report here a very rare case of chronic myeloid leukemia (CML) following long-term chemotherapy with 5'-deoxy-5-fluorouridine (5'-DFUR) for gastric cancer. A 69-year-old man was diagnosed with the chronic phase of CML. Six years previously, he underwent radical subtotal gastrectomy for gastric cancer, and was subsequently treated with oral anti-metabolite 5'-DFUR as adjuvant chemotherapy for 6 years. He was placed on imatinib therapy, and achieved a major molecular response 10 months after the initiation of therapy. This is the first reported case of therapy-related CML following 5'-DFUR treatment.
Tsuzuki
Motohiro
M
Department of Medicine, Fujita Health University, School of Medicine, Toyoake. mtsuzuki@fujita-hu.ac.jp
Handa
Kousuke
K
Yamamoto
Kiyoko
K
Hasegawa
Akio
A
Yamamoto
Yukiya
Y
Watanabe
Masato
M
Mizuta
Syuichi
S
Maruyama
Fumio
F
Okamoto
Masataka
M
Emi
Nobuhiko
N
Ezaki
Kohji
K
D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D005467:Floxuridine / Q000009:adverse effects*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000209:etiology*; D008297:Male; D016609:Neoplasms, Second Primary / Q000209:etiology*; D013274:Stomach Neoplasms / Q000188:drug therapy*; D013997:Time Factors
D000964:Antimetabolites, Antineoplastic; D005467:Floxuridine; C025034:doxifluridine