The microcalorimetric investigation of cellular suspensions of blood lymphocytes from healthily and suffering from atherosclerosis individuals.
The denaturation thermodynamic parameters--enthalpy (DeltaH) and temperature of hetero-and active chromatin of lymphocytes and metabolic heat of these cells were determined for healthy and suffering from atherosclerosis individuals. It is supposed that atherosclerosis disease leads to chromatin rebuilding in the interphase state and decrease of cell survival. The chromatin rebuilding may be imagined as partially unfolding of 30 nm chromatin fiber into 10 nm one due to loss of some part of H1 histone.
Monaselidze
J
J
E. Andronikashvili Institute of Physics.
Barbakadze
Sh
Sh
Gorgoshidze
M
M
Lezhava
T
T
Jokhadze
T
T
D002151:Calorimetry / Q000379:methods*; D002843:Chromatin / Q000378:metabolism; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis*; D006304:Health Status; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D013696:Temperature
D002843:Chromatin