title: Association of a single-nucleotide polymorphism in the pregnane X receptor (PXR 63396C-->T) with reduced concentrations of unboosted atazanavir.
abstract: This study investigated pregnane X receptor polymorphisms in relation to unboosted atazanavir plasma concentrations in 2 cohorts of patients. The polymorphism 63396T-->C predicted concentrations below the minimum effective concentration (150 ng/mL) with odds ratios of 18 (P = .008) and 5.13 (P = .02). Prospective studies determining potential clinical usefulness are now warranted.
authors.affiliation: Department of Infectious Diseases, University of Turin, Amedeo di Savoia Hospital, Turin, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Siccardi
authors.forename: Antonio
authors.initials: A
authors.lastname: D'Avolio
authors.forename: Lorena
authors.initials: L
authors.lastname: Baietto
authors.forename: Sara
authors.initials: S
authors.lastname: Gibbons
authors.forename: Mauro
authors.initials: M
authors.lastname: Sciandra
authors.forename: Daniela
authors.initials: D
authors.lastname: Colucci
authors.forename: Stefano
authors.initials: S
authors.lastname: Bonora
authors.forename: Saye
authors.initials: S
authors.lastname: Khoo
authors.forename: David J
authors.initials: DJ
authors.lastname: Back
authors.forename: Giovanni
authors.initials: G
authors.lastname: Di Perri
authors.forename: Andrew
authors.initials: A
authors.lastname: Owen
mesh_terms: D000328:Adult; D000069446:Atazanavir Sulfate; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy / Q000235:genetics; D017320:HIV Protease Inhibitors / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009842:Oligopeptides / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D020641:Polymorphism, Single Nucleotide; D000077297:Pregnane X Receptor; D011725:Pyridines / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D011987:Receptors, Steroid / Q000235:genetics* / Q000378:metabolism
chemical_list: D017320:HIV Protease Inhibitors; D009842:Oligopeptides; D000077297:Pregnane X Receptor; D011725:Pyridines; D011987:Receptors, Steroid; D000069446:Atazanavir Sulfate