Clerodane diterpenoids with NGF-potentiating activity from Ptychopetalum olacoides.
Four new clerodane-type diterpenoids, ptychonolide (1), 20-O-methylptychonal acetal (2), and an equilibrium mixture of ptychonal hemiacetal (3) and ptychonal (4), were isolated from the MeOH extract of the bark of a Brazilian plant, Ptychopetalum olacoides. The structure of 1 was elucidated as a clerodane-type diterpenoid on the basis of spectroscopic data, whereas 2 was assigned to an acetal derivative of 1. Compounds 3 and 4 existed as an equilibrium mixture. A mixture of compounds 3 and 4 was found to exhibit neurite outgrowth-promoting activities on NGF-mediated PC12 cells at concentrations ranging from 0.1 to 10.0 microM.
Tang
Wanxia
W
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.
Hioki
Hideaki
H
Harada
Kenichi
K
Kubo
Miwa
M
Fukuyama
Yoshiyasu
Y
D000818:Animals; D001938:Brazil; D045785:Diterpenes, Clerodane / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D015394:Molecular Structure; D020932:Nerve Growth Factor / Q000819:agonists*; D016501:Neurites / Q000187:drug effects*; D031656:Olacaceae / Q000737:chemistry*; D016716:PC12 Cells; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats
D045785:Diterpenes, Clerodane; D020932:Nerve Growth Factor