title: [Propionic acid fermentation by Propionibacterium freudenreichii CCTCC M207015 with a fibrous-bed bioreactor].
abstract: The production of propionic acid by Propionibacterium freudenreichii CCTCC M207015 was investigated in a Fibrous-bed bioreactor (FBB). The FBB was constructed by packing spiral cotton fibrous and immobilized into a bioreactor. By applying this bioreactor to propionic acid fermentation, the propionic acid yield had a significant improvement and reached 20.41 g/L, compared with the cell-free culture of 14.58 g/L (40 g/L of glucose). At the same time, the glucose exhausting time decreased from 120 h to 60 h. Batch fermentations at various glucose concentrations were carried out with FBB. Based on the analysis of the time course of production, fed-batch fermentation was also applied to produce propionic acid with FBB, the maximal propionic acid yield reached 45.91 g/L, and the proportion of propionic acid to total acids was about 72.31%.
authors.affiliation: State Key Laboratory of Materials-Oriented Chemical Engineering, College of Life Science and Pharmacy, Nanjing University of Technology, Nanjing 210009, China.
authors.forename: Xiaohai
authors.initials: X
authors.lastname: Feng
authors.forename: Bo
authors.initials: B
authors.lastname: Wu
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Shen
authors.forename: Hong
authors.initials: H
authors.lastname: Xu
mesh_terms: D019149:Bioreactors / Q000382:microbiology*; D005285:Fermentation; D005947:Glucose / Q000378:metabolism; D011422:Propionates / Q000378:metabolism*; D011424:Propionibacterium / Q000145:classification / Q000378:metabolism*
chemical_list: D011422:Propionates; D005947:Glucose; C029658:propionic acid