title: The effects of MPTP on the activation of microglia/astrocytes and cytokine/chemokine levels in different mice strains.
abstract: The effects of MPTP on two mouse strains with different MPTP sensitivities and immunological backgrounds were compared: MPTP-sensitive C57BL/6 mice (B6) with a propensity for Th1 and less MPTP-sensitive BALB/c mice (BALB) with a propensity for Th2. It was found that acute MPTP treatment induced behavioral dysfunction, activated microglia/astrocytes, and increased the levels of IL-10, IL-12(p40) IL-13, IFN-gamma, and MCP-1 in CSF in B6, but not in BALB. This suggests that variances in immunological backgrounds might be a major contributing factor in sensitivity differences to MPTP.
authors.affiliation: Cell Biology Section, Division of Basic Research, Louis Pasteur Center for Medical Research, 103-5, Sakyo-ku, Tanaka, Monzen-cho, Kyoto 606-8225, Japan. yyasuda@louis-pasteur.or.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Yasuda
authors.forename: T
authors.initials: T
authors.lastname: Shimoda
authors.forename: K
authors.initials: K
authors.lastname: Uno
authors.forename: N
authors.initials: N
authors.lastname: Tateishi
authors.forename: S
authors.initials: S
authors.lastname: Furuya
authors.forename: K
authors.initials: K
authors.lastname: Yagi
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: S
authors.initials: S
authors.lastname: Fujita
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D001253:Astrocytes / Q000187:drug effects*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D016207:Cytokines / Q000097:blood* / Q000134:cerebrospinal fluid*; D004334:Drug Administration Schedule; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D017628:Microglia / Q000187:drug effects*; D009068:Movement / Q000187:drug effects; D009414:Nerve Growth Factors / Q000378:metabolism; D009498:Neurotoxins / Q000494:pharmacology*; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000378:metabolism; D013045:Species Specificity; D013997:Time Factors; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
chemical_list: D016207:Cytokines; D009414:Nerve Growth Factors; D009498:Neurotoxins; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D014446:Tyrosine 3-Monooxygenase