title: Effect of powder characteristics on oral tablet disintegration.
abstract: This report describes an investigation of the factors affecting disintegration time in the mouth (DTM) of rapidly disintegrating tablets. The relation between DTM and stationary time of upper punch displacement (STP) was examined using a tableting process analyzer (TabAll). Results indicated that the bulk density of mixed excipient powder used for tablet preparation affects both DTM and STP. As the value of bulk density increased, STP became longer and DTM shorter. The results of a combination of granules and powder with or without a drug showed liner relation between apparent volume (reciprocal of bulk density) and DTM (r(2)=0.7332). For a DTM less than 60 s, a formulation with a bulk density greater 0.5 g/mL should be chosen with a compression force of 5 kN. The hardness of tablets could be greater than 3 kg if at least one high-compressibility excipient was used in the formulation.
authors.affiliation: Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo 194-8543, Japan.
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Makiko
authors.initials: M
authors.lastname: Fujii
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Watanabe
authors.forename: Masashi
authors.initials: M
authors.lastname: Tsukamoto
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Shibata
authors.forename: Masuo
authors.initials: M
authors.lastname: Kondoh
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Watanabe
mesh_terms: D002626:Chemistry, Pharmaceutical; D005079:Excipients / Q000737:chemistry*; D006244:Hardness; D006801:Humans; D011208:Powders; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods*; D013997:Time Factors
chemical_list: D005079:Excipients; D011208:Powders; D013607:Tablets