[Obtaining and study of monosaccharide derivatives of low-molecular-weight chitosan].
The possibility of obtaining monosaccharide derivatives of low-molecular-weight chitosan with the use of the Maillard reaction was studied. Chitosan derivatives (molecular weight, 24 and 5 kDa) obtained with glucosamine, N-acetyl galactosamine, galactose, and mannose with a substitution degree of 4-14% and a yield of 60-80% were obtained. Some physicochemical and biological properties of these derivatives were studied. We showed that monosaccharide derivatives of low-molecular-weight chitosan exhibited antibacterial activity. Chitosan at a concentration of 0.01% caused 100% death of bacteria B. subtilis and E. coil. The strongest antibacterial effect was exhibited by 24-kDa derivatives: only 0.02-0.08% of cells survived. These derivatives were two orders of magnitude more effective than the 5-kDa chitosan modified with galactose.
Il'ina
A V
AV
Kulikov
S N
SN
Chalenko
G I
GI
Gerasimova
N G
NG
Varlamov
V P
VP
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000254:growth & development; D048271:Chitosan / Q000737:chemistry*; D004926:Escherichia coli / Q000254:growth & development; D006601:Hexoses / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D008970:Molecular Weight
D000900:Anti-Bacterial Agents; D006601:Hexoses; D048271:Chitosan