Two cyathane-type diterpenoids from the liquid culture of Strobilurus tenacellus.
The structures of two new cyathane-type diterpenoids isolated from a liquid culture of Strobilurus tenacellus have been elucidated. The chemical structures of the new compounds 1 and 2 were identified as (12S)-11alpha,14alpha-epoxy-13alpha,14beta,15-trihydroxycyath-3-ene and (12R)-11alpha,14alpha-epoxy-13alpha,14beta,15-trihydroxycyath-3-ene, respectively, by spectral methods, including HR-EI-MS, and 1D- and 2D-NMR techniques. Compounds 1 and 2 show antimicrobial activity against Pseudomonas aeruginosa. In addition, both compounds were also tested for activity against human cancer cells, and 2 showed growth inhibitory activity against YMB and COLO 201 cells.
Shiono
Yoshihito
Y
Department of Bioresource Engineering, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, Japan. yshiono@tds1.tr.yamagata-u.ac.jp
Hiramatsu
Fuminori
F
Murayama
Tetsuya
T
Koseki
Takuya
T
Funakoshi
Takayuki
T
D000363:Agaricales / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
D004224:Diterpenes; C497675:cyathane