Successful treatment of adrenocortical carcinoma with pulmonary metastasis in a child: report of a case.
Adrenocortical carcinoma (ACC) in childhood is rare: in 2002, only three new cases were reported in Japan. Although there is no established therapeutic management system, margin-free complete surgical excision of the tumor is very important to a satisfactory outcome. We report a case of ACC with bilateral pulmonary metastasis in a 10-year-old boy. Preoperative chest computed tomography (CT) showed pulmonary metastasis with near-water density. The patient was treated successfully with complete surgical resection of the primary tumor and adjuvant chemotherapy, including mitotane. After bilateral lung surgery for the metastatic lesions, the plasma dehydroepiandrosterone sulfate level became negative.
Arai
Hiromasa
H
Department of General Surgery, Yokohama City University School of Medicine, 3-9 Fukuura Kanazawa-ku, Yokohama, 236-0004, Japan.
Rino
Yasushi
Y
Yamanaka
Sumitaka
S
Yukawa
Norio
N
Wada
Nobuyuki
N
Kato
Hiromi
H
Yanagimachi
Masakatsu
M
Goto
Hiroaki
H
Oshiro
Hisashi
H
Yamanaka
Shoji
S
Inayama
Yoshiaki
Y
Lee
Jin
J
Masuda
Munetaka
M
D000306:Adrenal Cortex Neoplasms / Q000473:pathology*; D018268:Adrenocortical Carcinoma / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D002648:Child; D003131:Combined Modality Therapy; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D008297:Male; D008939:Mitotane / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
D018931:Antineoplastic Agents, Hormonal; D008939:Mitotane