[Ultrasound-induced myocardial preconditioning: analysis of its effectiveness and mechanisms].
It has been shown that exposure of the isolated rat heart perfused according to Langendorff to therapeutic ultrasound (210 kHz and 0.5-1.5 W/cm2 ) induces a cardioprotective response similar to ischemic preconditioning. This reduces the infarct size and improves the postischemic systolic and diastolic function. The ATP-sensitive K+ channel blocker glybenclamide abolished the protection afforded by ultrasound; in contrast, the free radical scavenger N-2-MPG did not influence the ultrasound-induced cardioprotective response.
Galagudza
M M
MM
Shmonin
A A
AA
Mishchenko
K A
KA
Vlasov
T D
TD
Petrishchev
N N
NN
D000818:Animals; D003971:Diastole / Q000187:drug effects; D005905:Glyburide / Q000494:pharmacology; D019157:Ischemic Preconditioning, Myocardial / Q000379:methods*; D009203:Myocardial Infarction / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D026902:Potassium Channel Blockers / Q000494:pharmacology; D015221:Potassium Channels / Q000378:metabolism; D051381:Rats; D013599:Systole / Q000187:drug effects; D014464:Ultrasonic Therapy / Q000379:methods*
D026902:Potassium Channel Blockers; D015221:Potassium Channels; D005905:Glyburide