Sesquiterpene Glucosides from Chloranthus japonicus Sieb.
A new lindenane sesquiterpene glucoside named yinxiancaoside A (1), a new, rare bidesmosidic megastigmane sesquiterpene glucoside named yinxiancaoside B (5), and three known sesquiterpene glucosides, chloranoside A (2), pisumionoside (3), and sarcaglaboside A (4), were isolated from the whole plant of Chloranthus japonicus Sieb. The structures of the new compounds were established by an extensive study of their spectral data, especially 1D- and 2D-NMR. The cytotoxic activity of the isolated compounds against human hepatoma (Hepg-2), human ovarian carcinoma (OV420), and human breast cancer (MCF-7) cells was investigated.
Kuang
Haixue
H
Heilongjiang University of Chinese Medicine, 24 Heping Road, Harbin 150040, P. R. China. hxkuang@hotmail.com
Xia
Yonggang
Y
Yang
Bingyou
B
Wang
Qiuhong
Q
Lü
Shaowa
S
D002470:Cell Survival / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry*
D006027:Glycosides; D012717:Sesquiterpenes