[Methods to increase the encapsulation efficiency for liposomal drugs].
Liposomes as drug delivery systems--in comparison to the traditional dosage forms--offer the advantage of the targeted drug delivery and as a consequence, reduction of the side effects. In case of fluoroquinolone antibiotics, such as lomefloxacin, the liposomal encapsulation of the active ingredient can result in an enhancement of its therapeutic efficacy against intracellular bacteria. The aim to improve the liposomal encapsulation efficiency of drugs--which is one of the main factors influencing the therapeutic effect of vesicular dosage forms--is one of the important challenges in the field of pharmaceutical technology. In our experiments we prepared lomefloxacin containing multilamellar vesicles from various lipids using different hydrating solutions. We intended to study the effect of lipid composition, cholesterol content and surface charge of liposomes on the encapsulation efficiency of lomefloxacin. Our results can contribute to the rational design of fluoroquinolone containing liposomal drugs.
Kaszás
Nóra
N
Semmelweis Egyetem, Gyógyszerészeti Intézet, Budapest, Hogyes Endre utca 7. H-1092.
Budai
Marianna
M
Budai
Lívia
L
Gróf
Pál
P
Zimmer
Andreas
A
Klebovich
Imre
I
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D002214:Capsules; D004337:Drug Carriers; D004339:Drug Compounding / Q000379:methods; D016503:Drug Delivery Systems / Q000379:methods*; D005229:Fatty Acids, Monounsaturated; D008081:Liposomes; D000644:Quaternary Ammonium Compounds
D000900:Anti-Bacterial Agents; D002214:Capsules; D004337:Drug Carriers; D005229:Fatty Acids, Monounsaturated; D008081:Liposomes; D000644:Quaternary Ammonium Compounds; C070046:1,2-dioleoyloxy-3-(trimethylammonium)propane