title: Cytotoxic xenicane diterpenes from the brown alga Padina pavonia (L.) Gaill.
abstract: Column chromatography of the hexane fraction of a methanol extract of Padina pavonia (L.) Gaill. collected from the Red Sea at Hurghada, Egypt yielded 18,19-epoxyxenic-19-methoxy-18-hydroxy-4-acetoxy-6,9,13-triene (1) and 18,19-epoxyxenic-18,19-dimethoxy-4-hydroxy-6,9,13-triene (2). The isolated compounds have various antitumor activities against lung carcinoma (H460) and liver carcinoma (HepG2) human cell lines (in vitro).
authors.affiliation: Pharmacognosy Department, National Research Center, Dokki, Cairo, Egypt. NagwaEA@hotmail.com
authors.forename: Nagwa E
authors.initials: NE
authors.lastname: Awad
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Selim
authors.forename: Hemaia M
authors.initials: HM
authors.lastname: Metawe
authors.forename: Azza A
authors.initials: AA
authors.lastname: Matloub
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D000459:Phaeophyceae / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: C533962:18,19-epoxyxenic-18,19-dimethoxy-4-hydroxy-6,9,13-triene; C533961:18,19-epoxyxenic-19-methoxy-18-hydroxy-4-acetoxy-6,9,13-triene; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D010936:Plant Extracts