Potential anti-allergic acridone alkaloids from the roots of Atalantia monophylla.
Acridone alkaloids, cycloatalaphylline-A (1), N-methylcyclo-atalaphylline-A (2) and N-methylbuxifoliadine-E (3), were isolated from the dichloromethane and acetone extracts of the root of Atalantia monophylla along with eight known acridone alkaloids: buxifoliadine-A (4), buxifoliadine-E (5), N-methylatalaphylline (6), atalaphylline (7), citrusinine-I (8), N-methylataphyllinine (9), yukocitrine (10) and junosine (11) and two known coumarins: auraptene (12) and 7-O-geranylscopoletin (13). Their structures were elucidated on the basis of spectroscopic analyses. Compounds 2, 5 and 8 possessed appreciable anti-allergic activity in RBL-2H3 cells model with IC(50) values of 40.1, 6.1 and 18.7 microM, respectively.
Chukaew
Arnon
A
Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand.
Ponglimanont
Chanita
C
Karalai
Chatchanok
C
Tewtrakul
Supinya
S
D000166:Acridines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D054831:Acridones; D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D018926:Anti-Allergic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002460:Cell Line; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry*; D051381:Rats; D027821:Rutaceae / Q000737:chemistry*; D001619:beta-N-Acetylhexosaminidases / Q000187:drug effects
D000166:Acridines; D054831:Acridones; D000470:Alkaloids; D018926:Anti-Allergic Agents; D010936:Plant Extracts; C041300:acridone; D001619:beta-N-Acetylhexosaminidases