title: Evidence for internal filtration in the Genius system, performing slow low efficient daily dialysis in the intensive care unit.
abstract: BACKGROUND
  Since most intensive care units (ICUs) have no access to high-quality water, the Genius system, using ultrapure water and high-flux dialyzers, might be used during slow low efficient daily dialysis (SLEDD). To get an idea about convective removal, internal filtration (IF) was calculated and compared to other modalities.
  
  
  METHODS
  Validated with in vivo measurements, IF was calculated for 8 h Genius SLEDD and 4 h Genius standard dialysis with high-flux dialyzers, and for 8 h SLEDD and 4 h both with standard dialysis machines and low-flux as well as high-flux dialyzers.
  
  
  RESULTS
  In Genius SLEDD (FX80), IF was 2.36 l (hematocrit [Hct] 30%) and 3.37 l (Hct 40%). About the same amount of IF was found for the different dialysis modalities, except when using low-flux dialyzers, where no IF occurred.
  
  
  CONCLUSIONS
  The Genius system allows the implementation of high-flux dialysis with ultrapure dialysate, and can be run in a SLEDD mode in the ICU.
authors.affiliation: Renal Division, Department of Internal Medicine, Ghent University Hospital, Ghent, Belgium. sunny.eloot@ugent.be
authors.forename: Sunny
authors.initials: S
authors.lastname: Eloot
authors.forename: Wim
authors.initials: W
authors.lastname: Van Biesen
authors.forename: Annemieke
authors.initials: A
authors.lastname: Dhondt
authors.forename: Erik
authors.initials: E
authors.lastname: Billiet
authors.forename: Pascal
authors.initials: P
authors.lastname: Verdonck
authors.forename: Raymond
authors.initials: R
authors.lastname: Vanholder
mesh_terms: D006801:Humans; D007362:Intensive Care Units; D008962:Models, Theoretical; D017582:Renal Replacement Therapy / Q000295:instrumentation* / Q000379:methods*