title: Preeclampsia and subsequent risk of cancer: update from the Jerusalem Perinatal Study.
abstract: OBJECTIVE
  The purpose of this study was to examine the association between preeclampsia and cancer incidence.
  
  
  METHODS
  The Jerusalem Perinatal Study is a population-based cohort of all births to 41,206 residents of Western Jerusalem from 1964-76. Cancer incidence to 2004 was assessed by linkage of the cohort with the Israel Cancer Registry. Cox's proportional hazards models were constructed to estimate the hazard ratio for cancer among women who had had preeclampsia.
  
  
  RESULTS
  Preeclampsia was associated with a 1.23-fold increased risk of cancer at all sites, a 37% increased risk of breast cancer, and more than a doubling of ovarian cancer risk. Analysis by morphologic condition yielded significantly increased risks for malignancies that were classed as cystic mucinous and serous (relative risk, 1.96; 95% CI, 1.00-3.83) and for ductal, lobular, and medullary carcinomas (relative risk, 1.40; 95% CI, 1.07-1.83). No differential association was observed by sex of offspring.
  
  
  CONCLUSIONS
  Our study suggests that the previously described protective effect of preeclampsia on cancer is not universal.
authors.affiliation: Hebrew University-Hadassah Braun School of Public Health, Jerusalem, Israel. ronitcm@ekmd.huji.ac.il
authors.forename: Ronit
authors.initials: R
authors.lastname: Calderon-Margalit
authors.forename: Yechiel
authors.initials: Y
authors.lastname: Friedlander
authors.forename: Rivka
authors.initials: R
authors.lastname: Yanetz
authors.forename: Lisa
authors.initials: L
authors.lastname: Deutsch
authors.forename: Mary C
authors.initials: MC
authors.lastname: Perrin
authors.forename: Karine
authors.initials: K
authors.lastname: Kleinhaus
authors.forename: Efrat
authors.initials: E
authors.lastname: Tiram
authors.forename: Susan
authors.initials: S
authors.lastname: Harlap
authors.forename: Ora
authors.initials: O
authors.lastname: Paltiel
mesh_terms: D001943:Breast Neoplasms / Q000453:epidemiology* / Q000209:etiology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D007557:Israel / Q000453:epidemiology; D008297:Male; D010051:Ovarian Neoplasms / Q000453:epidemiology* / Q000209:etiology; D011225:Pre-Eclampsia / Q000453:epidemiology*; D011247:Pregnancy; D016016:Proportional Hazards Models; D012189:Retrospective Studies