title: Highly enantioselective copper-catalyzed ring opening of oxabicyclic alkenes with Grignard reagents.
abstract: A highly efficient copper-catalyzed enantioselective ring opening of oxabicylic alkenes with Grignard reagents has been developed by using chiral spiro phosphine ligands. Excellent trans selectivities, good yields, and high enantioselectivities are obtained for a broad range of Grignard reagents under mild reaction conditions. The catalyst system shows an extraordinary activity and the TON of the reaction reaches 9000.
authors.affiliation: State Key Laboratory and Institute of Elemento-Organic Chemistry Nankai University, Tianjin (China).
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Shou-Fei
authors.initials: SF
authors.lastname: Zhu
authors.forename: Xiang-Chen
authors.initials: XC
authors.lastname: Qiao
authors.forename: Qi-Lin
authors.initials: QL
authors.lastname: Zhou