Cytotoxic and antiplasmodial substances from marine-derived fungi, Nodulisporium sp. and CRI247-01.
Nodulisporacid A (1) was isolated from a marine-derived fungus Nodulisporium sp. CRIF1, while vermelhotin (5) was obtained from an unidentified fungus CRI247-01 (a member of the Order Pleosporales). Both 1 and 5 occurred as equilibrium E/Z mixtures. Ester derivatives (2 and 3) and vermelhotin (5) showed cytotoxic activity against eleven cancer cell lines. Nodulisporacid A (1) and vermelhotin (5) exhibited moderate antiplasmodial activity.
Kasettrathat
Chairut
C
Chulabhorn Research Institute and Chulabhorn Graduate Institute, Vipavadee-Rangsit Highway, Bangkok 10210, Thailand.
Ngamrojanavanich
Nattaya
N
Wiyakrutta
Suthep
S
Mahidol
Chulabhorn
C
Ruchirawat
Somsak
S
Kittakoop
Prasat
P
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D001688:Biological Products / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects; D011759:Pyrrolidines / Q000302:isolation & purification / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000302:isolation & purification / Q000494:pharmacology*; D013098:Xylariales / Q000737:chemistry*
D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D001688:Biological Products; D005663:Furans; D011759:Pyrrolidines; D011760:Pyrrolidinones; C534202:nodulisporacid A; C534203:vermelhotin; C009435:tetramic acid; C003422:tetronic acid; D015107:4-Butyrolactone