Dynamic behavioural changes in the Spontaneously Hyperactive Rat: 3. Control by reinforcer rate changes and predictability.
Variable intervals are widely believed to produce steady rates of responding. However, based on the calming effect of unpredictability in attention deficit hyperactivity disorder (ADHD) we hypothesised that an animal model of this disorder, the Spontaneously Hyperactive (or Hypertensive) Rat, would become less active following particularly variable sequences of interval-lengths in a variable interval schedule. From a large dataset of holepokes and tray-reports by rats in a variable interval reinforcement schedule, we extracted numerous short sequences of intervals on the basis of the first, second, and third derivatives of reinforcement timing (i.e. rate, acceleration, and jerk) in recent intervals. Sets of selected intervals were compared with one another to elucidate the effect of these different derivatives on behaviour in the current interval. Results show that SHR are more active after richer recent reinforcement; after decelerating reinforcers; and after predictable reinforcers. The hypothesis is supported. In conclusion, SHR behaviour largely complies with the Extended Temporal Difference model which in turn has been previously validated against published data in ADHD. The Extended TD model therefore is able to account for two species' behaviour in a wide range of experimental paradigms. SHR are similar in several respects to group averages of children with ADHD, except that SHR have reduced variability and perform actions faster than controls. Hyperactivity in the SHR is very dependent on momentary environmentally determined states, which is an important area for future investigation of ADHD.
Williams
Jonathan
J
Gatsby Computational Neuroscience Unit, University College London, London, UK. johwilliams@gmail.com
Sagvolden
Geir
G
Taylor
Eric
E
Sagvolden
Terje
T
D000818:Animals; D001007:Anxiety / Q000523:psychology; D001289:Attention Deficit Disorder with Hyperactivity / Q000523:psychology*; D003216:Conditioning, Operant; D004195:Disease Models, Animal; D005106:Exploratory Behavior; D005108:Extinction, Psychological; D006948:Hyperkinesis / Q000503:physiopathology / Q000523:psychology*; D009043:Motor Activity; D011177:Postal Service; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012055:Reinforcement Schedule; D013045:Species Specificity; D013997:Time Factors