title: Levodopa/carbidopa/entacapone-induced acute Pisa syndrome in a Parkinson's disease patient.
abstract: Pisa syndrome (PS) is a dystonic lateroflexion of the trunk with a postural disturbance resembling the leaning tower of Pisa. Initially reported as a side effect related to antipsychotic therapy, this original dystonic posture is also manifested in neurodegenerative disorders such as Alzheimer's disease and multiple system atrophy, or in rare idiopathic cases. Recent observations have described the onset of PS with subchronic course in patients affected by Parkinson's disease (PD). Here, we report on the acute development of PS in a parkinsonian patient during treatment with entacapone/levodopa/carbidopa combination. This case illustrates how, in contrast to previously well-known chronic/subchronic forms, this axial dystonic posture may occur in PD as an acute onset reversible type, related to levodopa treatment.
authors.affiliation: Centro per i Disordini del Movimento, Dipartimento di Scienze Cardiovascolari e Neurologiche, Sezione Neurologia, University of Cagliari, Italy. paosol29@yahoo.it
authors.forename: Paolo
authors.initials: P
authors.lastname: Solla
authors.forename: Antonino
authors.initials: A
authors.lastname: Cannas
authors.forename: Socrate
authors.initials: S
authors.lastname: Congia
authors.forename: Gianluca
authors.initials: G
authors.lastname: Floris
authors.forename: Rosa
authors.initials: R
authors.lastname: Aste
authors.forename: Paolo
authors.initials: P
authors.lastname: Tacconi
authors.forename: Maria Giovanna
authors.initials: MG
authors.lastname: Marrosu
mesh_terms: D000978:Antiparkinson Agents / Q000009:adverse effects*; D002230:Carbidopa / Q000009:adverse effects; D002396:Catechols / Q000009:adverse effects; D020821:Dystonic Disorders / Q000139:chemically induced* / Q000000981:diagnostic imaging; D006801:Humans; D007980:Levodopa / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009570:Nitriles / Q000009:adverse effects; D010300:Parkinson Disease / Q000000981:diagnostic imaging / Q000188:drug therapy; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D014326:Tropanes
chemical_list: D000978:Antiparkinson Agents; D002396:Catechols; D009570:Nitriles; D014326:Tropanes; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane; D007980:Levodopa; C071192:entacapone; D002230:Carbidopa