Recursive estimation of transient inhomogeneous zeta potential in microchannel turns using velocity measurements.
In the various biomedical microfluidic devices the target biomolecules are delivered by activating electroosmotic flows. The zeta potential of a microchannel wall, which determines the strength of the electroosmotic flow, is apt to change due to the adhesion of biomolecules such as DNA or protein especially around the microchannel turns. The resulting transient inhomogeneous profile of zeta potential alters flow pattern, volumetric flow rate and the band broading of solutes. In the present work, we have developed a method for the recursive estimation of transient inhomogeneous zeta potential in microchannel turns using velocity measurements. For the real time implementation of the present method, a compact and accurate reduced-order model is derived using the Karhunen-Loève Galerkin method and the Helmholtz-Smoluchowski slip velocity. The present scheme of recursive estimation is an important prerequisite to the real time control of microfluidic devices.
Park
H M
HM
Department of Chemical and Biomolecular Engineering, Sogang University, Seoul, South Korea. hmpark@sogang.ac.kr
Kim
T W
TW
D004247:DNA / Q000737:chemistry*; D053841:Electroosmosis; D046210:Microfluidic Analytical Techniques / Q000379:methods*; D008962:Models, Theoretical; D011506:Proteins / Q000737:chemistry*
D011506:Proteins; D004247:DNA