title: Crystallin proteins and amyloid fibrils.
abstract: Improper protein folding (misfolding) can lead to the formation of disordered (amorphous) or ordered (amyloid fibril) aggregates. The major lens protein, alpha-crystallin, is a member of the small heat-shock protein (sHsp) family of intracellular molecular chaperone proteins that prevent protein aggregation. Whilst the chaperone activity of sHsps against amorphously aggregating proteins has been well studied, its action against fibril-forming proteins has received less attention despite the presence of sHsps in deposits found in fibril-associated diseases (e.g. Alzheimer's and Parkinson's). In this review, the literature on the interaction of alphaB-crystallin and other sHsps with fibril-forming proteins is summarized. In particular, the ability of sHsps to prevent fibril formation, their mechanisms of action and the possible in vivo consequences of such associations are discussed. Finally, the fibril-forming propensity of the crystallin proteins and its implications for cataract formation are described along with the potential use of fibrillar crystallin proteins as bionanomaterials.
authors.affiliation: School of Chemistry & Physics, The University of Adelaide, Adelaide, South Australia 5005, Australia.
authors.forename: H
authors.initials: H
authors.lastname: Ecroyd
authors.forename: John A
authors.initials: JA
authors.lastname: Carver
mesh_terms: D038261:Alexander Disease / Q000378:metabolism; D000544:Alzheimer Disease / Q000378:metabolism; D000682:Amyloid / Q000378:metabolism* / Q000648:ultrastructure; D002386:Cataract / Q000378:metabolism; D007562:Creutzfeldt-Jakob Syndrome / Q000378:metabolism; D050888:Heat-Shock Proteins, Small / Q000378:metabolism / Q000502:physiology; D006801:Humans; D007908:Lens, Crystalline / Q000378:metabolism; D049329:Nanostructures; D017510:Protein Folding; D011499:Protein Processing, Post-Translational; D017434:Protein Structure, Tertiary; D038203:alpha-Crystallin B Chain / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*
chemical_list: D000682:Amyloid; D050888:Heat-Shock Proteins, Small; D038203:alpha-Crystallin B Chain