title: Design and synthesis of bis-amide and hydrazide-containing derivatives of malonic acid as potential HIV-1 integrase inhibitors.
abstract: HIV-1 integrase (IN) is an attractive and validated target for the development of novel therapeutics against AIDS. In the search for new IN inhibitors, we designed and synthesized three series of bis-amide and hydrazide-containing derivatives of malonic acid. We performed a docking study to investigate the potential interactions of the title compounds with essential amino acids on the IN active site.
authors.affiliation: Dipartimento Farmaco Chimico Tossicologico, Università di Sassari, Via Muroni 23/A, 07100 Sassari, Italy. mario.sechi@uniss.it
authors.forename: Mario
authors.initials: M
authors.lastname: Sechi
authors.forename: Ugo
authors.initials: U
authors.lastname: Azzena
authors.forename: Maria Paola
authors.initials: MP
authors.lastname: Delussu
authors.forename: Roberto
authors.initials: R
authors.lastname: Dallocchio
authors.forename: Alessandro
authors.initials: A
authors.lastname: Dessì
authors.forename: Alessia
authors.initials: A
authors.lastname: Cosseddu
authors.forename: Nicolino
authors.initials: N
authors.lastname: Pala
authors.forename: Nouri
authors.initials: N
authors.lastname: Neamati
mesh_terms: D000577:Amides; D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001386:Azides; D020134:Catalytic Domain; D003198:Computer Simulation; D015195:Drug Design; D019428:HIV Integrase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D008314:Malonates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011485:Protein Binding; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D019380:Anti-HIV Agents; D001386:Azides; D019428:HIV Integrase Inhibitors; D008314:Malonates; C030290:malonic acid