Novel isocyanide-based three-component one-pot synthesis of cyanophenylamino-acetamide derivatives.
A one-pot multicomponent synthesis of a novel class of cyanophenylamino-acetamides through the conversion of primary amides to the corresponding nitriles, starting from simple and readily available inputs including 2-aminobenzamide, an aldehyde, and an isocyanide in the presence of p-toluenesulfonic acid as a catalyst, in excellent yields at room temperature in ethanol as a green reaction medium is described.
Shaabani
Ahmad
A
Department of Chemistry, Shahid Beheshti UniVersity, P.O. Box 19396-4716, Tehran, Iran. a-shaabani@cc.sbu.ac.ir
Maleki
Ali
A
Mofakham
Hamid
H
Khavasi
Hamid Reza
HR
D000081:Acetamides / Q000138:chemical synthesis*; D000588:Amines; D000814:Aniline Compounds / Q000138:chemical synthesis*; D003486:Cyanides / Q000737:chemistry*; D055772:Green Chemistry Technology; D009570:Nitriles
D000081:Acetamides; D000588:Amines; D000814:Aniline Compounds; D003486:Cyanides; D009570:Nitriles