[Recurrent febrile episodes in childhood. From immunodeficiency to normality].
Fever is one of the leading symptom in childhood diseases. If there are recurrent febrile episodes, one have to distinguish between recurrent infections in the normal age range, periodic fever syndromes or even a primary immunodeficiency. Diagnostic tools to distinguish one from another are reported. The warning signs for primary immunodeficiency are listed and discussed. For periodic fever syndromes, the PFAPA syndrome, the most frequent in Swiss children, is discussed in some detail.
Duppenthaler
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Universitätsklinik für Kinderheilkunde, Inselspital Bern. andrea.duppenthaler@insel.ch
D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005335:Fever of Unknown Origin / Q000276:immunology*; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000175:diagnosis* / Q000276:immunology; D007223:Infant; D009894:Opportunistic Infections / Q000175:diagnosis* / Q000276:immunology; D010507:Periodicity; D011379:Prognosis; D012008:Recurrence