title: Circulating fatty acids and prostate cancer risk in a nested case-control study: the Multiethnic Cohort.
abstract: OBJECTIVE
  Dietary fat, including specific fatty acids, has been proposed to contribute to prostate cancer pathogenesis, but findings from the studies based on biomarkers have been conflicting.
  
  
  METHODS
  We examined the association between erythrocyte membrane fatty acid composition and prostate cancer risk in a nested case-control study within a multiethnic cohort of African Americans, Native Hawaiians, Japanese Americans, Latinos, and Whites. Analyses included 376 cases and 729 matched controls. Conditional logistic regression was used to estimate the odds ratios and 95% confidence intervals with adjustment for multiple covariates.
  
  
  RESULTS
  No significant association was found for saturated, mono- and polyunsaturated fatty acid, or for specific n-3 and n-6 fatty acids, even when the analysis was limited to advanced or high grade prostate cancer. In ethnic specific analyses, there was a positive association with palmitic acid in Japanese Americans that was significantly different from the null results in other groups. There was also an increased risk with n-3 fatty acids and the ratio of n-3/n-6 fatty acids in Whites.
  
  
  CONCLUSIONS
  Although there was a suggestion of ethnic specific associations with some fatty acids, our overall findings do not support a role for fatty acids in prostate carcinogenesis.
authors.affiliation: Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA. spark@crch.hawaii.edu
authors.forename: Song-Yi
authors.initials: SY
authors.lastname: Park
authors.forename: Lynne R
authors.initials: LR
authors.lastname: Wilkens
authors.forename: Susanne M
authors.initials: SM
authors.lastname: Henning
authors.forename: Loïc
authors.initials: L
authors.lastname: Le Marchand
authors.forename: Kun
authors.initials: K
authors.lastname: Gao
authors.forename: Marc T
authors.initials: MT
authors.lastname: Goodman
authors.forename: Suzanne P
authors.initials: SP
authors.lastname: Murphy
authors.forename: Brian E
authors.initials: BE
authors.lastname: Henderson
authors.forename: Laurence N
authors.initials: LN
authors.lastname: Kolonel
mesh_terms: D001741:Black or African American / Q000208:ethnology; D000368:Aged; D001213:Asian / Q000208:ethnology; D016022:Case-Control Studies; D002462:Cell Membrane / Q000737:chemistry; D004912:Erythrocytes / Q000737:chemistry; D005227:Fatty Acids / Q000097:blood*; D006254:Hawaii; D006630:Hispanic or Latino / Q000208:ethnology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000097:blood* / Q000208:ethnology*; D012307:Risk Factors; D044465:White People / Q000208:ethnology
chemical_list: D005227:Fatty Acids