title: [Hypertrophic cardiomyopathy: course characteristics in long-term follow-up].
abstract: OBJECTIVE
  To detect relations between intracardiac hemodynamics and clinicoanamnestic features of patients with hypertrophic cardiomyopathy (HCMP).
  
  
  METHODS
  We observed 84 patients with different clinical variants of a HCMP course. Of them, 15 patients were treated surgically. The patients were followed up from 3 to 24 years (mean 8.4 +/- 1.1 years). All the patients have undergone standard ECG, transthoracic echocardiography with doppler echocardiography, 24-h ECG monitoring, part of them--stress echocardiography (exercise and/or dobutamine), MRT of the heart, coronaroangiography and probing of the heart.
  
  
  RESULTS
  The analysis of cardiac remodeling parameters in HCMP patients showed significance of diastolic disorders in development of basic clinical symptoms of the disease. A rise of atrial-ventricular index (AVI) reflects severity of a HCMP course. Patients with the most severe course of the disease had AVI equal or higher than 1.1. In obstructive and non-obstructive variants of HCMP time of the first symptoms onset did not differ significantly. In the disease onset the patients had asthenic syndrome, cardialgia, dyspnea. The disease ends with heart failure.
  
  
  CONCLUSIONS
  Long-term follow-up of HCMP patients and comparison of clinico-morphological parameters revealed the role of diastolic dysfunction in formation of clinical symptoms.
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Belenkov
authors.forename: E V
authors.initials: EV
authors.lastname: Privalova
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Kaplunova
authors.forename: A A
authors.initials: AA
authors.lastname: Fomin
mesh_terms: D000328:Adult; D002312:Cardiomyopathy, Hypertrophic / Q000175:diagnosis / Q000503:physiopathology*; D017023:Coronary Angiography; D018450:Disease Progression; D015150:Echocardiography, Doppler; D015716:Electrocardiography, Ambulatory; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012720:Severity of Illness Index; D013318:Stroke Volume / Q000502:physiology*; D013997:Time Factors; D016277:Ventricular Function, Left / Q000502:physiology*; D020257:Ventricular Remodeling / Q000502:physiology*