[Pregnancy and antiphospholipid antibodies].
Antiphospholipid syndrome is one of the few treatable causes of pregnancy loss, and successful pregnancy rates of 70% or more can be achieved with appropriate treatment. Pregnancy in these women is associated with increased rates of preeclampsia, placental insufficiency, and preterm delivery. Several studies indicate that heparin, usually combined with low-dose aspirin, is beneficial in this indication. Recent works underlines the role of complement activation in a murine model of antiphospholipid pregnancy loss, which should be confirmed in Human.
Le Guern
Véronique
V
Service de Médecine Interne, Hôpital Cochin, Université Paris Descartes, Paris, France. veronique.le-guern@cch.aphp.fr
Goffinet
François
F
D000818:Animals; D017152:Antibodies, Antiphospholipid / Q000276:immunology; D000925:Anticoagulants / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000276:immunology / Q000517:prevention & control*; D001241:Aspirin / Q000627:therapeutic use; D003167:Complement Activation / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D005313:Fetal Death / Q000209:etiology; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D010927:Placental Insufficiency / Q000209:etiology; D011225:Pre-Eclampsia / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology / Q000517:prevention & control*; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000209:etiology
D017152:Antibodies, Antiphospholipid; D000925:Anticoagulants; D006493:Heparin; D001241:Aspirin