Chemotaxis: TorC before you Akt...
Chemotaxis uses intertwined signalling pathways, each individually dispensable. Recent work shows that Dictyostelium PKB/Akt can be spatially regulated independently of phosphatidylinositol (3,4,5)-trisphosphate via phosphorylation by TOR complex 2, placing this complex at the hub of chemotaxis.
King
Jason S
JS
CR-UK Beatson Institute for Cancer Research, Switchback Road, Bearsden, Glasgow G61 1BD, UK. j.king@beatson.gla.ac.uk
Insall
Robert H
RH
D000818:Animals; D002633:Chemotaxis / Q000502:physiology*; D004023:Dictyostelium / Q000502:physiology*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*
D014157:Transcription Factors; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt