Synthesis and evaluation of novel boron-containing complexes of potential use for the selective treatment of malignant melanoma.
Boron-containing complexes that have the potential to irreversibly accumulate in melanoma cells have been prepared by reaction of amino acids with 9-methoxy-9-borabicyclo[3.3.1]nonane. The ability of each complex to act as a substrate for tyrosinase has been probed by oximetry. Increased uptake of the lead candidate in a tyrosinase-rich cell line, compared with a tyrosinase-absent cell line, is reported, with results correlating well with that for a drug currently approved for BNCT.
Bonjoch
Josep
J
Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, 08028 Barcelona, Spain.
Drew
Michael G B
MG
González
Asensio
A
Greco
Francesca
F
Jawaid
Samaila
S
Osborn
Helen M I
HM
Williams
Nana Aba O
NA
Yaqoob
Parveen
P
D001896:Boron Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology*; D015394:Molecular Structure; D010084:Oxidation-Reduction / Q000187:drug effects; D013329:Structure-Activity Relationship
D001896:Boron Compounds