title: [Modern approaches to treatment of thrombosis in pregnant women, carriers of hereditary anomalies--F-V-Leiden and G20210A mutation].
abstract: studying of efficiency low-molecular heparin for preventive maintenance and treatment of thromboembolic disorders in pregnant women, carriers of F-V- L and F-II-20210 G-A mutation. Under supervision, there were 27 women with thrombosis during pregnancy from 19 to 39 years old. The lower extremities veins thromboses was diagnosed by duplex sonography. F-V- Leiden, F-II-20210 G-A and MTHFR C 677T gene mutation was defined by PCR-PELP method. To all pregnant women Fraxiparin and vitamins of B group was appointed during pregnancy period; at presence of MTHFR a folic acid was appointed in addition. It is concluded that application of Fraxiparin is an effective method of treatment of thrombosis during pregnancy and women--carriers F-V- Leiden, F-II-20210 G-A and MTHFR C 677T gene mutation. High efficiency of Fraxiparin confirms with change of parameters of various parts of a hemostasis and return development of thrombosis evidence.
authors.forename: Sh K
authors.initials: ShK
authors.lastname: Shakhbazov
authors.forename: R Sh
authors.initials: RSh
authors.lastname: Rustamov
mesh_terms: D000328:Adult; D004252:DNA Mutational Analysis; D005165:Factor V / Q000235:genetics*; D005260:Female; D006580:Genetic Carrier Screening; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D017354:Point Mutation / Q000235:genetics; D011247:Pregnancy; D012307:Risk Factors; D013927:Thrombosis / Q000188:drug therapy* / Q000235:genetics*
chemical_list: D005165:Factor V; D042965:Methylenetetrahydrofolate Reductase (NADPH2)