title: Antigenic mimicry of the HIV envelope by AIDS-associated pathogens.
abstract: Only one broadly neutralizing anti-HIV antibody, 2G12, recognises the envelope sugars of HIV. In the present study, we show that 2G12 also recognises Candida albicans and Candida tropicalis with high affinity (11 nmol/l) through a carbohydrate-dependent interaction (50% inhibitory concentration for D-fructose, 12 mmol/l). This is the first report of a neutralizing HIV antibody displaying cross-reactivity with another pathogen, revealing that the carbohydrate neutralization determinant of HIV, defined by 2G12, is more widespread amongst immunogenic, microbial surfaces than previously recognized.
authors.affiliation: Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford, UK.
authors.forename: D Cameron
authors.initials: DC
authors.lastname: Dunlop
authors.forename: Alexander
authors.initials: A
authors.lastname: Ulrich
authors.forename: Ben J
authors.initials: BJ
authors.lastname: Appelmelk
authors.forename: Dennis R
authors.initials: DR
authors.lastname: Burton
authors.forename: Raymond A
authors.initials: RA
authors.lastname: Dwek
authors.forename: Nicole
authors.initials: N
authors.lastname: Zitzmann
authors.forename: Christopher N
authors.initials: CN
authors.lastname: Scanlan
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology; D000946:Antigens, Fungal / Q000276:immunology; D000080908:Broadly Neutralizing Antibodies; D002175:Candida / Q000276:immunology*; D003429:Cross Reactions; D015483:HIV Antibodies; D015699:HIV Envelope Protein gp120 / Q000276:immunology*; D006801:Humans; D018716:Molecular Mimicry
chemical_list: C529157:2G12 monoclonal antibody; D000911:Antibodies, Monoclonal; D000946:Antigens, Fungal; D000080908:Broadly Neutralizing Antibodies; D015483:HIV Antibodies; D015699:HIV Envelope Protein gp120