Re-creation of the genetic composition of a founder population.
Human ethnic groups are frequently comprised of two or more founder populations. One of these founding populations is often available for contemporary sampling. We describe a method for reconstructing the composition of a missing founder population using the highly informative haplotypes comprising the HLA system. An application of the method is demonstrated using bone marrow registry samples of African Americans. We use contemporary samples of African Americans and European Americans to derive haplotypes of the West African founder populations. This approach may also be useful for reconstructing ancestral haplotypes for regions elsewhere in the genome.
Klitz
William
W
University of California, Berkeley, USA. klitz@berkeley.edu
Maiers
Martin
M
Gragert
Loren
L
D044383:Black People / Q000235:genetics*; D018703:Founder Effect; D006680:HLA Antigens / Q000235:genetics; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008957:Models, Genetic; D044382:Population Groups / Q000235:genetics*; D044465:White People / Q000235:genetics*; D001741:Black or African American
D006680:HLA Antigens