title: [Mathematical modeling of the evolution of bacterial populations in continuous cultures with regard to the nonmutagenic variability of genome].
abstract: A mathematical model of the evolution of the genetic structure of the bacterial population during prolonged cultivation in a chemostat has been constructed. In addition to genetic mutations, some factors of the nonmutagenic variability of genome were taken into account, namely, the structural reorganization of plasmid and virus DNA, the DNA loss due to cellular division, the conjugative transfer of plasmids, and the plasmid replication. The general model also takes into account the formation of cellular aggregates during conjugation. The results of numerical and analytical investigation of the special cases of the general model were treated. Simplified mathematical models are considered, which can be used to explain the experimentally observed evolutionary variations resulting from the plurality of evolution attractors, multi-stage microevolutionary transitions, the semi-stable states of the bacterial population genome, and the undamped oscillations of the genetic structure of the population during prolonged cultivation in the chemostat.
authors.forename: Iu M
authors.initials: IuM
authors.lastname: Aponin
authors.forename: E A
authors.initials: EA
authors.lastname: Aponina
mesh_terms: D001419:Bacteria; D018407:Bacterial Physiological Phenomena; D005075:Biological Evolution; D017753:Ecosystem; D014644:Genetic Variation / Q000502:physiology*; D016680:Genome, Bacterial / Q000502:physiology*; D008954:Models, Biological