Inherited pelvic organ prolapse in the mouse: preliminary evaluation of a new murine model.
The objective of this study was to report the initial anatomic, radiographic, and genetic evaluations of a novel form of spontaneous pelvic organ prolapse (S-POP) in mice. We observed S-POP in a colony of UPII-SV40T transgenic mice developed for studies on bladder cancer. We utilized magnetic resonance imaging and necropsy to characterize this finding. We have established a breeding colony to identify inheritance patterns and for future studies. Selective breeding isolated the S-POP phenotype from the transgene. In contrast to other animal models, the S-POP mouse does not require an obligatory antecedent event to manifest pelvic organ prolapse. Necropsy and imaging demonstrate significant displacement of the pelvic organs distal to the pelvic floor in both sexes. The appearance of the POP is similar to that seen in the human female phenotype. Preliminary breeding studies indicate an autosomal dominant inheritance pattern. This mouse may be an effective animal model for the study of POP in humans.
McNanley
Anna R
AR
Department of Obstetrics and Gynecology, University of Rochester Medical Center, 601 Elmwood Avenue, PO Box 668, Rochester, NY 14642, USA. anna_mcnanley@urmc.rochester.edu
Johnson
Aimee M
AM
Flynn
Michael K
MK
Wood
Ronald W
RW
Kennedy
Scott D
SD
Reeder
Jay E
JE
D000818:Animals; D052858:Cystocele / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D008279:Magnetic Resonance Imaging; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D010375:Pedigree; D010388:Pelvis / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D010641:Phenotype; D014057:Tomography, X-Ray Computed; D014596:Uterine Prolapse / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology