title: Drug toxicity, HIV progression, or comorbidity of aging: does tipranavir use increase the risk of intracranial hemorrhage?
abstract: The US Food and Drug Administration has issued a warning that tipranavir may be associated with increased risk of intracranial hemorrhage. We studied 2 large cohorts to estimate the background rate of intracranial hemorrhage and compared it with rates reported among persons who had been exposed to tipranavir.
authors.affiliation: Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut 06516, USA.
authors.forename: Amy C
authors.initials: AC
authors.lastname: Justice
authors.forename: David S
authors.initials: DS
authors.lastname: Zingmond
authors.forename: Kirsha S
authors.initials: KS
authors.lastname: Gordon
authors.forename: Shawn L
authors.initials: SL
authors.lastname: Fultz
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Goulet
authors.forename: Joseph T
authors.initials: JT
authors.lastname: King
authors.forename: Dawn M
authors.initials: DM
authors.lastname: Bravata
authors.forename: Hernan
authors.initials: H
authors.lastname: Valdez
authors.forename: Michael
authors.initials: M
authors.lastname: Kraft
authors.forename: Kristin M
authors.initials: KM
authors.lastname: Mattocks
mesh_terms: D000328:Adult; D000367:Age Factors; D019380:Anti-HIV Agents / Q000009:adverse effects*; D002140:California / Q000453:epidemiology; D015331:Cohort Studies; D016208:Databases, Factual; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D020300:Intracranial Hemorrhages / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008484:Medicaid / Q000706:statistics & numerical data; D008875:Middle Aged; D011725:Pyridines / Q000009:adverse effects*; D011753:Pyrones / Q000009:adverse effects*; D012307:Risk Factors; D013449:Sulfonamides; D014481:United States / Q000453:epidemiology; D014728:Veterans / Q000706:statistics & numerical data
chemical_list: D019380:Anti-HIV Agents; D011725:Pyridines; D011753:Pyrones; D013449:Sulfonamides; C107201:tipranavir