title: Transplantation of human umbilical cord blood cells for the repair of myocardial infarction.
abstract: Cell therapy for myocardial disease is a rapidly evolving medical field. A vast and growing body of evidence indicates that cell-based strategies have promising therapeutic potential. Recent clinical and pre-clinical studies demonstrate a varying degree of improvement in cardiac function using different sources of adult stem cell types such as bone marrow-derived progenitor cells and skeletal myoblasts. However, the currently available regimens for cell transplantation into the infarcted myocardium have limitations from practical points of view, in particular the logistics in harvesting donor cells. Accordingly, there is an urgent need for a new source of adult stem cells. Human umbilical cord blood (HUCB) is a good candidate and appears to have several key advantages. HUCB is a viable and practical source of progenitor cells. Compared to bone marrow, HUCB contains a higher number of immature stem/progenitor cells. The aim of our review is to provide an update on the preclinical experiments with emphasis on the possible mechanisms underlying the therapeutic benefits of HUCB cell transplantation for myocardial infarction.
authors.affiliation: Department of Cardiology, Xiangya Hospital, Southern Central University, Changsha, China. yuguolong123@yahoo.com.cn
authors.forename: Guolong
authors.initials: G
authors.lastname: Yu
authors.forename: Cesar V
authors.initials: CV
authors.lastname: Borlongan
authors.forename: Christine E
authors.initials: CE
authors.lastname: Stahl
authors.forename: Seong Jin
authors.initials: SJ
authors.lastname: Yu
authors.forename: Eunkyung
authors.initials: E
authors.lastname: Bae
authors.forename: Tianlun
authors.initials: T
authors.lastname: Yang
authors.forename: Jiyang
authors.initials: J
authors.lastname: Zhou
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Xiong
authors.forename: Liqion
authors.initials: L
authors.lastname: Qin
authors.forename: Bo
authors.initials: B
authors.lastname: Zhou
mesh_terms: D000818:Animals; D036101:Cord Blood Stem Cell Transplantation; D005312:Fetal Blood / Q000166:cytology / Q000637:transplantation; D015316:Genetic Therapy; D006801:Humans; D009203:Myocardial Infarction / Q000628:therapy*