title: Prevalence of traditional cardiovascular risk factors in African-American women with systemic lupus erythematosus (SLE): findings from the breakfast with a buddy biomarkers of lupus study.
abstract: African-American women are at high risk for systemic lupus erythematosus (SLE). Women with SLE are 5 to 8 times more likely to develop cardiovascular disease (CVD). The objective of this study was to characterize the prevalence of traditional CVD risk factors and the markers of sub-clinical atherosclerosis between African-American SLE cases (n=28) and controls (n=73). Significant differences were observed between SLE cases and controls in the areas of high blood pressure (68% of SLE cases, 42% of controls, p = 0.02), current smoking (18% of SLE cases, 15% of controls, p = 0.01), and average fasting glucose (85 mg/dL in SLE cases, 98 mg/dL in controls, p = 0.02). SLE cases displayed non-significantly higher HDL-c levels, lower LDL-c levels, and lower BMI. These results must be interpreted cautiously since the study sample was small and highly select. Larger studies are recommended to elucidate non-traditional mechanisms that may modulate some of the increased risk for CVD associated with SLE in women.
authors.affiliation: Institute for Partnerships to Eliminate Health Disparities, University of South Carolina, Columbia 29210, USA. willi425@gwm.sc.edu
authors.forename: Edith
authors.initials: E
authors.lastname: Williams
authors.forename: Joan
authors.initials: J
authors.lastname: Dorn
authors.forename: Carlos
authors.initials: C
authors.lastname: Crespo
mesh_terms: D015415:Biomarkers / Q000097:blood*; D044383:Black People; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000503:physiopathology*; D015995:Prevalence; D012307:Risk Factors; D011795:Surveys and Questionnaires; D001741:Black or African American
chemical_list: D015415:Biomarkers