Longitudinal changes in triglycerides according to ANGPTL4[E40K] genotype and longitudinal body weight change in the atherosclerosis risk in communities study.
OBJECTIVE
Allelic variation in the adipokine angiopoietin-like 4 gene (ANGPTL4[E40K]) has been cross-sectionally associated with triglycerides, but the effects of genotype, or the interaction between genotype and body weight, on longitudinal triglyceride change have not been studied.


METHODS
Body weight, triglycerides, and ANGPTL4[E40K] genotype were determined at baseline (1987-1989) and at 3 follow-up exams (1990-1992, 1993-1995, 1996-1998) in 7,939 white ANGPTL4[E40K] G allele homozygotes and 344 A allele carriers. Changes in body weight and triglycerides were characterized as the difference between exam 4 and baseline measurements.


RESULTS
ANGPTL4[E40K] A allele carriers had triglyceride concentrations that were 15 to 18 mg/dL lower than G allele homozygotes at all exams (P<0.0001). Triglycerides increased in both genotype groups over the 9-year period (+19.1+/-0.9 and +16.2+/-4.1 mg/dL in GG and GA/AA, respectively; P difference, 0.48). Weight gain was associated with increased triglycerides to a comparable degree in both genotype groups (+5.5+/-0.3 and +4.3+/-0.9 mg/dL per 2-kg increase in body weight in GG and GA/AA, respectively, p interaction=0.30).


CONCLUSIONS
Differences in triglyceride concentrations between ANGPTL4[E40K] A allele carriers and G allele homozygotes are maintained over time, but the degree of increase in triglycerides was similar between groups and was not modified by body weight changes.
Nettleton
Jennifer A
JA
Division of Epidemiology and Disease Control, University of Texas Health Science Center, Houston, TX 77030, USA. Jennifer.A.Nettleton@uth.tmc.edu
Volcik
Kelly A
KA
Demerath
Ellen W
EW
Boerwinkle
Eric
E
Folsom
Aaron R
AR
D000368:Aged; D000075803:Angiopoietin-Like Protein 4; D042682:Angiopoietins / Q000235:genetics*; D050197:Atherosclerosis / Q000097:blood / Q000235:genetics; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood* / Q000235:genetics*; D014481:United States; D015430:Weight Gain / Q000235:genetics*
C474772:ANGPTL4 protein, human; D000075803:Angiopoietin-Like Protein 4; D042682:Angiopoietins; D014280:Triglycerides