Generation and function of human regulatory CD8+ T cells induced by a humanized OKT3 monoclonal antibody hOKT3gamma1 (Ala-Ala).
Recent studies with a humanized anti-CD3 antibody in clinical trials suggested that this drug can induce regulatory CD8+ T cells. In this review, we discuss how these regulatory human CD8+ cells can be generated and the possible molecular tools they may use to inhibit immune responses. We compare our data on CD8+ regulatory cells induced by anti-CD3 stimulation with those reported in other experimental systems to identify both common and unique features of these cells.
Ablamunits
Vitaly
V
Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Herold
Kevan C
KC
D061067:Antibodies, Monoclonal, Humanized; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002986:Clinical Trials as Topic; D006801:Humans; D016853:Muromonab-CD3 / Q000276:immunology* / Q000627:therapeutic use; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D061067:Antibodies, Monoclonal, Humanized; D016853:Muromonab-CD3; C502540:teplizumab