Bioactive constituents from Chinese natural medicines. XXXII. aminopeptidase N and aldose reductase inhibitors from Sinocrassula indica: structures of sinocrassosides B(4), B(5), C(1), and D(1)-D(3).
From the methanolic extract of the whole plant of Sinocrassula indica (Crassulaceae), six new flavonol glycosides, sinocrassosides B(4) (1), B(5) (2), C(1) (3), D(1) (4), D(2) (5), and D(3) (6), were isolated together with 30 compounds. The structures of 1-6 were elucidated on the basis of chemical and physicochemical evidence. In addition, several constituents were found to show inhibitory effects on aminopeptidase N and aldose reductase.
Morikawa
Toshio
T
Kyoto Pharmaceutical University, Kyoto, Japan.
Xie
Haihui
H
Wang
Tao
T
Matsuda
Hisashi
H
Yoshikawa
Masayuki
M
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D018826:CD13 Antigens / Q000037:antagonists & inhibitors*; D045744:Cell Line, Tumor; D029627:Crassulaceae / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D047309:Flavones / Q000138:chemical synthesis* / Q000494:pharmacology*; D006027:Glycosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D007908:Lens, Crystalline / Q000187:drug effects / Q000201:enzymology; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D004791:Enzyme Inhibitors; D047309:Flavones; D006027:Glycosides; D011480:Protease Inhibitors; D000449:Aldehyde Reductase; D018826:CD13 Antigens