Starting at the endophenotype: A role for alpha-CaMKII in schizophrenia?
Using an endophenotype-driven screen, a new study finds that α-calcium/calmodulin kinase II mutant mice exhibit a range of behavioral abnormalities related to schizophrenia. Perhaps most strikingly, this cluster of schizophrenia-related endophenotypes was associated with abnormal neurogenesis in the adult hippocampus, raising the possibility that disrupted adult neurogenesis lies at the core of this and other psychiatric disorders.
Frankland
Paul W
PW
Sakaguchi
Masanori
M
Arruda-Carvalho
Maithé
M
D000818:Animals; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Q000378:metabolism*; D018891:Dentate Gyrus / Q000201:enzymology / Q000473:pathology / Q000503:physiopathology / Q000648:ultrastructure; D058068:Endophenotypes; D006801:Humans; D008569:Memory Disorders / Q000150:complications / Q000503:physiopathology; D051379:Mice; D012559:Schizophrenia / Q000201:enzymology*
D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2