Deterministic dynamics in neuronal discharge from pallidotomy targets.
The non-linear dynamic specificity of the firing pattern discharged from neurons of the internal globus pallidus (GPi) was investigated by recording their spontaneous firing using a microelectrode during posteroventral pallidotomy in eight patients with Parkinson's disease. Raw data from the cells were processed to extract spiking events (discharges above a selected threshold) and the interspike interval was measured. Using the unstable periodic orbits extraction method, significant period-1, -2 and -3 orbits were identified in burst firing discharged from the GPi cells in all eight patients, suggesting that deterministic dynamics exist in the timing of the discharges. As well as providing a useful peri-operative technique for locating posteroventral pallidotomy targets in Parkinson's disease, this method also provides a promising basis for investigating characteristic neuronal discharges in other regions of the brain and for various other neurological disorders.
Li
W
W
Institute of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, People's Republic of China.
Jia
D
D
Wang
J-L
JL
Liang
Q
Q
Jian
Z
Z
Wang
X-L
XL
He
S
S
Gao
G
G
D000200:Action Potentials / Q000502:physiology*; D000368:Aged; D005260:Female; D005917:Globus Pallidus / Q000166:cytology / Q000502:physiology; D006801:Humans; D008297:Male; D008839:Microelectrodes; D008875:Middle Aged; D009474:Neurons / Q000502:physiology*; D053860:Pallidotomy; D010300:Parkinson Disease / Q000503:physiopathology / Q000601:surgery