title: Microgravimetric lectin biosensor based on signal amplification using carbohydrate-stabilized gold nanoparticles.
abstract: A highly sensitive microgravimetric lectin biosensor has been developed using carbohydrate-stabilized Au nanoparticles as a signal amplifier; mannose-stabilized Au nanoparticles formed a sandwich-type complex with the target Con A specifically bound to a mannose-modified Au QCM electrode to give an amplified frequency response.
authors.affiliation: Department of Chemistry and Center for Bioactive Molecular Hybrids, Yonsei University, Seoul 120-749, Korea.
authors.forename: Young-Ku
authors.initials: YK
authors.lastname: Lyu
authors.forename: Kyung-Rae
authors.initials: KR
authors.lastname: Lim
authors.forename: Bo Young
authors.initials: BY
authors.lastname: Lee
authors.forename: Kwan Soo
authors.initials: KS
authors.lastname: Kim
authors.forename: Won-Yong
authors.initials: WY
authors.lastname: Lee
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods; D002241:Carbohydrates / Q000737:chemistry*; D003208:Concanavalin A / Q000032:analysis*; D004566:Electrodes; D006046:Gold / Q000737:chemistry*; D008358:Mannose / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D012680:Sensitivity and Specificity; D013499:Surface Properties; D013997:Time Factors
chemical_list: D002241:Carbohydrates; D003208:Concanavalin A; D006046:Gold; D008358:Mannose