title: Investigation of diffuse correlation spectroscopy in multi-layered media including the human head.
abstract: In this work, diffuse correlation spectroscopy (DCS) is explored in multi-layered geometries. A quantitative comparison of an homogeneous versus a two-layered model efficiencies to recover flow changes is presented. By simulating a realistic human head with MRI anatomical data, we show that the two-layered model allows distinction between changes in superficial layers and brain. We also show that the two-layered model provides a better estimate of the flow change than the homogeneous one. Experimental measurements with a two-layered dynamical phantom confirm the ability of the two-layered analytical model to distinguish flow increase in each layer.
authors.affiliation: Institut de génie biomédical, Ecole Polytechnique de Montréal, C.P. 6079, succ. Centre-Ville, Montréal, Qc, H3C 3A7, Canada. louis-2.gagnon@polymtl.ca
authors.forename: Louis
authors.initials: L
authors.lastname: Gagnon
authors.forename: Michèle
authors.initials: M
authors.lastname: Desjardins
authors.forename: Julien
authors.initials: J
authors.lastname: Jehanne-Lacasse
authors.forename: Louis
authors.initials: L
authors.lastname: Bherer
authors.forename: Frédéric
authors.initials: F
authors.lastname: Lesage
mesh_terms: D001921:Brain / Q000033:anatomy & histology / Q000473:pathology; D002560:Cerebrovascular Circulation; D003198:Computer Simulation; D004058:Diffusion; D006257:Head / Q000033:anatomy & histology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D055095:Optics and Photonics; D019047:Phantoms, Imaging; D017785:Photons; D013053:Spectrophotometry / Q000379:methods; D013057:Spectrum Analysis / Q000379:methods*