Effects of various drugs on alcohol-induced oxidative stress in the liver.
The major aim of this work was to investigate how alcohol-induced oxidative stress in combined chemotherapy changes the metabolic function of the liver in experimental animals. This research was conducted to establish how bromocriptine, haloperidol and azithromycin, applied to the experimental model, affected the antioxidative status of the liver. The following parameters were determined: reduced glutathione, activities of glutathione peroxidase, glutathione reductase, peroxidase, catalase, xanthine oxidase and lipid peroxidation intensity. Alanine transaminase was measured in serum. Alcohol stress (AO group) reduced glutathione and the activity of xanthine oxidase and glutathione peroxidase, but increased catalase and alanine transaminase activity. The best protective effect was achieved with the bromocriptine (AB1 group), while other groups had similar effects on the studied parameters.
Popovic
Mira
M
Department of Chemistry, Faculty of Sciences, Trg Dositeja Obradovica 3, 21000 Novi Sad, Serbia. popovic@ih.ns.ac.yu
Janicijevic-Hudomal
Snezana
S
Kaurinovic
Biljana
B
Rasic
Julijana
J
Trivic
Svetlana
S
D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D017963:Azithromycin / Q000494:pharmacology; D001971:Bromocriptine / Q000494:pharmacology; D002374:Catalase / Q000378:metabolism; D000431:Ethanol / Q000633:toxicity*; D005978:Glutathione / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D006220:Haloperidol / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D009195:Peroxidase / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014969:Xanthine Oxidase / Q000378:metabolism
D001971:Bromocriptine; D000431:Ethanol; D017963:Azithromycin; D002374:Catalase; D009195:Peroxidase; D014969:Xanthine Oxidase; D005980:Glutathione Reductase; D000410:Alanine Transaminase; D005978:Glutathione; D006220:Haloperidol