Th17 and treg cells innovate the TH1/TH2 concept and allergy research.
Allergic reactions are caused by harmless allergens, which are recognized by the specific immune system. Allergen-specific T cells are assumed to play a key role in the sensitization phase and in immunological memory. Current immunological concepts suggest that asymptomatic T-cell memory cells also exist, tagging the allergen as harmless and preventing an inappropriate response and thus allergic symptoms. Proinflammatory T cells mediate allergic inflammation by exceeding the induction of IgE and competing with other T-cell subsets. Therefore, molecular mechanisms leading to pro- or anti-inflammatory T-cell memory cells appear as the key mechanism in allergy.
Schmidt-Weber
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Allergy and Clinical Immunology, Imperial College London, London, UK.
D000818:Animals; D000917:Antibody Formation; D002454:Cell Differentiation; D005786:Gene Expression Regulation; D006801:Humans; D006967:Hypersensitivity / Q000097:blood / Q000235:genetics / Q000276:immunology*; D007156:Immunologic Memory; D020381:Interleukin-17 / Q000276:immunology / Q000378:metabolism*; D010641:Phenotype; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D018417:Th1 Cells / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D018418:Th2 Cells / Q000276:immunology* / Q000378:metabolism / Q000473:pathology
D020381:Interleukin-17