Antiprothrombin antibody testing: detection and clinical utility.
Anticardiolipin antibody (aCL), anti-beta2 glycoprotein I antibodies, and lupus anticoagulant (LA) are the only laboratory tests considered within the revised criteria for the classification of the antiphospholipid syndrome (APS). Recently, antibodies against phosphatidylserine-prothrombin complex (aPS/PT) have been detected, and these antibodies, rather than antibodies against prothrombin alone, are closely associated with APS and LA. The sensitivity and specificity of aPS/PT for the diagnosis of APS were assessed in a population of patients with a variety of autoimmune disorders. aCL and aPS/PT have similar diagnostic value for APS, therefore aPS/PT should be further explored, not only for research purposes but also as a candidate for one of the laboratory criteria for the classification of the APS.
Oku
Kenji
K
Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Atsumi
Tatsuya
T
Amengual
Olga
O
Koike
Takao
T
D017152:Antibodies, Antiphospholipid / Q000097:blood* / Q000276:immunology*; D016736:Antiphospholipid Syndrome / Q000097:blood* / Q000175:diagnosis*; D006403:Hematologic Tests / Q000379:methods / Q000592:standards; D006801:Humans; D010718:Phosphatidylserines / Q000276:immunology*; D011516:Prothrombin / Q000276:immunology*
D017152:Antibodies, Antiphospholipid; D010718:Phosphatidylserines; D011516:Prothrombin