title: Acoustic cry characteristics of infants exposed to methadone during pregnancy.
abstract: OBJECTIVE
  Infant cry characteristics reflect the neurological and medical status of the infant. This study compared the acoustic cry characteristics of infants born to mothers maintained on methadone during pregnancy with those of infants not exposed to methadone during pregnancy.
  
  
  METHODS
  At 42 weeks of post-menstrual age, 89 crying episodes ranging in duration from 1.15 to 1.97 sec were collected from 10 methadone-exposed (ME) and 10 non-methadone-exposed (NE) infants. Cry utterances were analysed acoustically using spectrographic displays and measures of cry utterance duration and fine-grained analyses of the fundamental frequency calculated for each cry.
  
  
  RESULTS
  No between-group differences were found on measures of cry duration or fundamental frequency. However, analyses of frequency perturbation showed that the cry utterances of ME infants were characterized by significantly higher levels of frequency perturbation than the cries of infants not exposed to methadone. These effects largely persisted after statistical control for the confounding effects of other maternal drug use during pregnancy.
  
  
  CONCLUSIONS
  The crying behaviour of infants exposed prenatally to the synthetic opiate, methadone, is characterized by higher levels of vocal fold vibratory perturbation than NE infants. These findings suggest the possibility of early, subtle neurological vulnerability in this high-risk group of infants.
authors.affiliation: Canterbury Child Development Research Group, Department of Psychology, University of Canterbury, Christchurch, New Zealand.
authors.forename: Zoe L
authors.initials: ZL
authors.lastname: Quick
authors.forename: Michael P
authors.initials: MP
authors.lastname: Robb
authors.forename: Lianne J
authors.initials: LJ
authors.lastname: Woodward
mesh_terms: D000014:Abnormalities, Drug-Induced; D000162:Acoustics; D000701:Analgesics, Opioid / Q000009:adverse effects*; D003448:Crying; D005260:Female; D006801:Humans; D007229:Infant Welfare; D007231:Infant, Newborn; D018811:Maternal Exposure; D008691:Methadone / Q000009:adverse effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
chemical_list: D000701:Analgesics, Opioid; D008691:Methadone