Enhanced gamma interferon responses of mouse spleen cells following immunotherapy for tuberculosis relapse.
Gamma interferon responses of spleen cells in mice were examined during postchemotherapy relapse of intraperitoneally induced latent tuberculous infection. The mycobacterial extract RUTI, which prevented the relapse, significantly enhanced the immune responses to secreted and structural recombinant mycobacterial antigens, suggesting that RUTI-mediated protection was mediated by activated T cells.
Gil
Olga
O
Unitat de Tuberculosi Experimental, Department of Microbiology, Fundació Institut per a la Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Catalonia, Spain.
Vilaplana
Cristina
C
Guirado
Evelyn
E
Díaz
Jorge
J
Cáceres
Neus
N
Singh
Mahavir
M
Cardona
Pere-Joan
PJ
D000818:Animals; D007167:Immunotherapy / Q000379:methods*; D007371:Interferon-gamma / Q000096:biosynthesis*; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D051379:Mice; D012008:Recurrence; D013154:Spleen / Q000276:immunology*; D014376:Tuberculosis / Q000628:therapy*
D007371:Interferon-gamma