title: Burkholderia pseudomallei meningitis following inadequate treatment of melioidotic mycotic aneurysm.
abstract: We report a 64-year-old man presenting with meningitis caused by Burkholderia pseudomallei predisposed by persistent aortic graft infection following inadequate treatment of a melioidotic mycotic aneurysm. The relapse of melioidosis presenting as acute meningitis is a unique event. Successful treatment of deep-seated melioidosis can only be achieved when robust antimicrobial therapy is combined with appropriate surgical debridement.
authors.affiliation: Department of Infectious Diseases, Singapore General Hospital, Outram Road, Singapore 169608. pchlebicki@hotmail.com
authors.forename: M P
authors.initials: MP
authors.lastname: Chlebicki
authors.forename: A
authors.initials: A
authors.lastname: Kurup
authors.forename: Y K
authors.initials: YK
authors.lastname: Sin
mesh_terms: D000284:Administration, Oral; D000785:Aneurysm, Infected / Q000150:complications* / Q000628:therapy*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001011:Aorta / Q000382:microbiology / Q000637:transplantation; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects; D019121:Burkholderia Infections / Q000209:etiology* / Q000382:microbiology* / Q000628:therapy; D016957:Burkholderia pseudomallei / Q000378:metabolism*; D004318:Doxycycline / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008554:Melioidosis / Q000150:complications* / Q000628:therapy*; D008581:Meningitis / Q000209:etiology* / Q000382:microbiology* / Q000628:therapy; D008875:Middle Aged; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D004318:Doxycycline