[Using the pol gene sequence results in clinical practice and HIV epidemiology].
In order to detect mutations in protease and reverse transcriptase regions determining the resistance of human immunodeficiency virus (HIV) to antiretroviral drugs, sequencing of pol gene was used. Itwas concluded that HIV epidemic in Yamal region is characterized by heterogeneity of HIV-1 subtype population with trend to domination of recombinant and ground variants and spreading of mutant Mut-77 strain. Obtained results demonstrate the possibility of identification of mutations as epidemiological markers which permits their use for epidemiologic investigations.
Volova
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LIu
Grezina
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D000328:Adult; D019380:Anti-HIV Agents / Q000494:pharmacology; D004252:DNA Mutational Analysis; D024882:Drug Resistance, Viral / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D015658:HIV Infections / Q000453:epidemiology* / Q000821:virology*; D016333:HIV Protease / Q000235:genetics; D054303:HIV Reverse Transcriptase / Q000235:genetics; D015497:HIV-1 / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D009154:Mutation; D011995:Recombination, Genetic; D012307:Risk Factors; D012800:Siberia / Q000453:epidemiology; D015819:Substance Abuse, Intravenous; D054302:pol Gene Products, Human Immunodeficiency Virus / Q000235:genetics*
D019380:Anti-HIV Agents; D054302:pol Gene Products, Human Immunodeficiency Virus; D054303:HIV Reverse Transcriptase; D016333:HIV Protease