Arsenite but not arsenate inhibits general proteoglycan synthesis in cultured arterial smooth muscle cells.
Epidemiological and experimental studies have suggested that exposure to metalloid arsenic constitutes a risk factor for vascular disease associated with atherosclerosis. Since in atherosclerosis, types of proteoglycans (PGs) present change depending on the stage, we investigated the effect of 2 chemical forms of inorganic arsenic-a trivalent sodium arsenite and a pentavalent sodium arsenate-on the synthesis of PGs in cultured arterial smooth muscle cells. The results indicate that arsenite but not arsenate, at a noncytotoxic level, inhibits general PG synthesis independent of cell density. Arsenite may be one of the chemical forms of inorganic arsenic that influences the PG composition in blood vessel walls during the progression of vascular disorders such as atherosclerosis.
Fujiwara
Yasuyuki
Y
Yamamoto
Chika
C
Hirooka
Takashi
T
Terada
Naoko
N
Satoh
Masahiko
M
Kaji
Toshiyuki
T
D000818:Animals; D001149:Arsenates / Q000633:toxicity*; D018053:Arsenites / Q000633:toxicity*; D002417:Cattle; D002452:Cell Count; D002478:Cells, Cultured; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D011509:Proteoglycans / Q000096:biosynthesis*; D017670:Sodium Compounds / Q000633:toxicity*
D001149:Arsenates; D018053:Arsenites; D011509:Proteoglycans; D017670:Sodium Compounds; C017947:sodium arsenite; C009277:sodium arsenate