Antioxidant and neuroprotective effects of synthesized sintenin derivatives.
Three series of sintenin derivatives (compounds 1-14) were designed and prepared and their antioxidative and neuroprotective effects were evaluated. The in vitro models of scavenging 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals, chelating ferrous ions, inhibiting the rat brain homogenates lipid peroxidation, and protecting neurons damaged by hydrogen peroxide were employed for bioassays. It was found that sintenin derivatives 4 and 13 showed remarkable antioxidative and neuroprotective activities.
Yang
Lei Xiang
LX
Department of TCM and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Zhang
Li Juan
LJ
Huang
Ke Xin
KX
Kun Li
Xiao
X
Hu
Li Hong
LH
Wang
Xiao Yu
XY
Stockigt
Joachim
J
Zhao
Yu
Y
D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry; D002478:Cells, Cultured; D002614:Chelating Agents / Q000737:chemistry / Q000494:pharmacology; D006861:Hydrogen Peroxide / Q000737:chemistry / Q000494:pharmacology; D015227:Lipid Peroxidation; D009474:Neurons / Q000187:drug effects; D018696:Neuroprotective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D010851:Picrates / Q000737:chemistry; D011422:Propionates / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
D000975:Antioxidants; D001713:Biphenyl Compounds; D002614:Chelating Agents; D018696:Neuroprotective Agents; D010851:Picrates; D011422:Propionates; C499736:sintenin; D006861:Hydrogen Peroxide; C004931:1,1-diphenyl-2-picrylhydrazyl