The endoplasmic reticulum as a potential therapeutic target in nonalcoholic fatty liver disease.
The endoplasmic reticulum (ER) has emerged as a key to understanding the development and consequences of hepatic fat accumulation in nonalcoholic fatty liver disease (NAFLD). An essential function of this organelle is the proper assembly of proteins that are destined for intracellular organelles and the cell surface. Recent evidence suggests that chemical chaperones that enhance the functional capacity of the ER improve liver function in obesity and NAFLD. These chaperones may therefore provide a novel potential therapeutic strategy in NAFLD.
Gentile
Christopher L
CL
Colorado State University, Department of Food Science and Human Nutrition, Gifford 234, Fort Collins, CO 80523-1571, USA.
Pagliassotti
Michael J
MJ
D000818:Animals; D003920:Diabetes Mellitus / Q000473:pathology; D004721:Endoplasmic Reticulum / Q000187:drug effects* / Q000473:pathology; D005234:Fatty Liver / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D018832:Molecular Chaperones / Q000494:pharmacology / Q000502:physiology; D009765:Obesity / Q000473:pathology
D018832:Molecular Chaperones