Ultra low fouling zwitterionic polymers with a biomimetic adhesive group.
Biomimetic polymers with a zwitterionic moiety for ultra low fouling and a catechol end group for surface anchoring have been developed. Binding tests of the adhesive polymers on various surfaces, including amino (NH(2)), hydroxyl (OH), and methyl (CH(3)) terminated self-assembled monolayers (SAMs) along with bare gold, were performed under acidic and basic conditions. Protein adsorption from single protein solutions of fibrinogen, lysozyme, and complex media of 10-100% blood plasma and serum was measured using a surface plasmon resonance (SPR) sensor. Under optimized conditions, the coated surfaces are highly resistant to non-specific protein adsorption from both single protein solutions and blood serum/plasma. Furthermore, the 3-day accumulation of Pseudomonas aeruginosa on the coated surfaces was evaluated in situ in a laminar flow chamber. Results show that the coated surfaces are highly resistant to bacterial adhesion and biofilm formation. This work demonstrates a convenient and efficient method for using zwitterionic polymers with a catechol anchor group to achieve ultra low fouling surfaces via surface modification, for applications in complex media.
Li
Guozhu
G
Department of Chemical Engineering, University of Washington, Seattle, WA 98195, USA.
Cheng
Gang
G
Xue
Hong
H
Chen
Shengfu
S
Zhang
Fengbao
F
Jiang
Shaoyi
S
D000269:Adhesives; D000327:Adsorption; D001422:Bacterial Adhesion; D018441:Biofilms; D040761:Biomimetic Materials; D032701:Biomimetics; D002396:Catechols; D007477:Ions; D008689:Methacrylates; D011506:Proteins / Q000493:pharmacokinetics; D011550:Pseudomonas aeruginosa
D000269:Adhesives; D002396:Catechols; D007477:Ions; D008689:Methacrylates; D011506:Proteins; C521589:sulfobetaine methacrylate polymer; C034221:catechol