Nhlh2: a basic helix-loop-helix transcription factor controlling physical activity.
In mice, targeted deletion of the basic helix-loop-helix transcription factor, nescient helix-loop-helix 2 (Nhlh2), leads to adult-onset obesity and reduced physical activity. We propose the novel hypothesis that transcriptional activity by Nhlh2 (NHLH2 in humans) controls either the ability or the motivation for exercise.
Good
Deborah J
DJ
Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, USA. goodd@vt.edu
Coyle
Christopher A
CA
Fox
Dana L
DL
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics* / Q000378:metabolism; D017353:Gene Deletion; D008040:Genetic Linkage; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D009042:Motivation; D009043:Motor Activity / Q000235:genetics*; D009765:Obesity / Q000235:genetics; D014157:Transcription Factors / Q000172:deficiency / Q000235:genetics / Q000378:metabolism
D051792:Basic Helix-Loop-Helix Proteins; D014157:Transcription Factors; C076747:NHLH2 protein, human