title: AMPKalpha2 counteracts the development of cardiac hypertrophy induced by isoproterenol.
abstract: As AMP-activated protein kinase (AMPK) controls protein translation, an anti-hypertrophic effect of AMPK has been suggested. However, there is no genetic evidence to confirm this hypothesis. We investigated the contribution of AMPKalpha2 in the control of cardiac hypertrophy by using AMPKalpha2-/- mice submitted to isoproterenol. The isoproterenol-induced cardiac hypertrophy, measured by left ventricular mass and histological examination, was significantly higher in AMPKalpha2-/- than in WT animals. Moreover, the intensification of cardiac hypertrophy found in AMPKalpha2-/- mice can be linked to the abnormal basal overstimulation of the p70 ribosomal S6 protein kinase, an enzyme known to regulate protein translation and cell growth. In conclusion, this work shows that AMPKalpha2 plays a role of brake for the development of cardiac hypertrophy.
authors.affiliation: Université catholique de Louvain, Division of Cardiology, 55 Avenue Hippocrate, CARD5550, B-1200 Brussels, Belgium.
authors.forename: Elham
authors.initials: E
authors.lastname: Zarrinpashneh
authors.forename: Christophe
authors.initials: C
authors.lastname: Beauloye
authors.forename: Audrey
authors.initials: A
authors.lastname: Ginion
authors.forename: Anne-Catherine
authors.initials: AC
authors.lastname: Pouleur
authors.forename: Xavier
authors.initials: X
authors.lastname: Havaux
authors.forename: Louis
authors.initials: L
authors.lastname: Hue
authors.forename: Benoit
authors.initials: B
authors.lastname: Viollet
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Vanoverschelde
authors.forename: Luc
authors.initials: L
authors.lastname: Bertrand
mesh_terms: D055372:AMP-Activated Protein Kinases; D000818:Animals; D017379:Hypertrophy, Left Ventricular / Q000139:chemically induced / Q000235:genetics* / Q000473:pathology; D007545:Isoproterenol / Q000633:toxicity; D051379:Mice; D018345:Mice, Knockout; D009097:Multienzyme Complexes / Q000235:genetics* / Q000378:metabolism; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000235:genetics* / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D038762:Ribosomal Protein S6 Kinases, 70-kDa / Q000378:metabolism
chemical_list: D009097:Multienzyme Complexes; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt; D038762:Ribosomal Protein S6 Kinases, 70-kDa; D055372:AMP-Activated Protein Kinases; D007545:Isoproterenol