Chronic fatigue syndrome and the central nervous system.
An increasing amount of neuroimaging evidence supports the hypothesis that chronic fatigue syndrome patients have structural or functional abnormalities within the brain. Moreover, some neurotrophic factors, neurotransmitters and cytokines have also been evaluated in order to elucidate the mechanism of abnormal neuropsychic findings in chronic fatigue syndrome. In this review, we suggest that the focal point of chronic fatigue syndrome research should be transferred to the central nervous system.
Chen
R
R
Department of General Medicine, Kanazawa Medical University, Ishikawa, Japan.
Liang
F X
FX
Moriya
J
J
Yamakawa
J
J
Sumino
H
H
Kanda
T
T
Takahashi
T
T
D000305:Adrenal Cortex Hormones / Q000378:metabolism; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D002490:Central Nervous System / Q000033:anatomy & histology / Q000502:physiology / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D016207:Cytokines / Q000378:metabolism; D003952:Diagnostic Imaging; D015673:Fatigue Syndrome, Chronic / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D010913:Pituitary-Adrenal System / Q000502:physiology; D012701:Serotonin / Q000378:metabolism
D000305:Adrenal Cortex Hormones; D019208:Brain-Derived Neurotrophic Factor; D016207:Cytokines; D012701:Serotonin