title: Inter-strain differences in glucocorticoid and mineralocorticoid effects on macrophage and lymphocyte functions in mice.
abstract: We showed previously and we confirm here that macrophages from three mouse strains are differentially sensitive to the inhibition of expression of key inflammatory proteins (iNOS-II, IL-1 beta) by dexamethasone, a specific glucocorticoid receptor agonist (C57BL/6>DBA/2>BALB/c). Here we show that aldosterone (a specific mineralocorticoid agonist) has no effect on iNOS-II or IL-1 beta expression in macrophages from these mouse strains but decreases IL-1ra expression, with small inter-strain differences. This mechanism may be involved in the pro-inflammatory effect of this hormone. Concanavalin A-stimulated lymphocytes proliferation is also differentially sensitive to dexamethasone according to the strain, but insensitive to aldosterone.
authors.affiliation: Laboratoire PsyNuGen, INRA UMR1286, CNRS UMR5226, Université de Bordeaux 2, France. harizihedi33@yahoo.fr
authors.forename: H
authors.initials: H
authors.lastname: Harizi
authors.forename: P
authors.initials: P
authors.lastname: Mormède
authors.forename: J-B
authors.initials: JB
authors.lastname: Corcuff
mesh_terms: D000450:Aldosterone / Q000494:pharmacology; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D016207:Cytokines / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005938:Glucocorticoids / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D008901:Mineralocorticoids / Q000494:pharmacology*; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D013045:Species Specificity
chemical_list: D016207:Cytokines; D005938:Glucocorticoids; D008901:Mineralocorticoids; D000450:Aldosterone; D003907:Dexamethasone; D052247:Nitric Oxide Synthase Type II