Minocycline: a neuroprotective agent for hypoxic-ischemic brain injury in the neonate?
Minocycline is a second-generation tetracycline and a potential neuroprotective intervention following brain injury. However, despite the recognized beneficial effects of minocycline in a multitude of adult disease states, the clinical application of minocycline in neonates is contentious. Tetracyclines, as a class, are not usually administered to neonates, but there is compelling evidence that minocycline reduces brain injury after neonatal hypoxic-ischemic brain injury. This Review focuses on the evidence for minocycline use in neonates by considering aspects of pharmacology, drug regimens, functional outcomes, and mechanisms of action.
Buller
Kathryn M
KM
Perinatal Research Centre, University of Queensland Centre for Clinical Research, Herston, Queensland, Australia. k.buller@uq.edu.au
Carty
Michelle L
ML
Reinebrant
Hanna E
HE
Wixey
Julie A
JA
D000818:Animals; D000831:Animals, Newborn; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D000975:Antioxidants / Q000008:administration & dosage; D017209:Apoptosis / Q000187:drug effects; D001812:Blood-Brain Barrier / Q000187:drug effects; D001921:Brain / Q000187:drug effects; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000188:drug therapy*; D018730:Infant Behavior / Q000187:drug effects; D007231:Infant, Newborn; D061965:Matrix Metalloproteinase Inhibitors; D008911:Minocycline / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D009336:Necrosis / Q000188:drug therapy; D009474:Neurons / Q000187:drug effects; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*
D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D061965:Matrix Metalloproteinase Inhibitors; D018696:Neuroprotective Agents; D008911:Minocycline