Fast, acid-free, and selective lactamization of lactones in ionic liquids.
A fast and acid-free one-pot 0.2-30 mmol microwave methodology for direct ionic liquid-mediated preparation of lactams from lactones and primary amines has been developed. The protocol was investigated with a wide range of primary amines and a handful of lactones, including substrates with acid-sensitive substituents. Both gamma-lactams and delta-lactams were, despite the complete absence of a Brønsted acid, obtained in useful to excellent yields after only 35 min of microwave processing.
Orrling
Kristina M
KM
Organic Pharmaceutical Chemistry, Department of Medicinal Chemistry, Uppsala Biomedical Center, Uppsala University, P.O. Box 574, SE-751 23 Uppsala, Sweden.
Wu
Xiongyu
X
Russo
Francesco
F
Larhed
Mats
M
D052578:Ionic Liquids; D007769:Lactams / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry*; D008722:Methods; D008872:Microwaves
D052578:Ionic Liquids; D007769:Lactams; D007783:Lactones