title: [Design and synthesis of a type of benzopyran derivatives with insulin-sensitizing activity].
abstract: Ten novel compounds were designed and synthesized on the basis of compound 1, their insulin-sensitizing activities were evaluated in 3T3-L1 cells. Results showed that compound 10 exhibited strong differentiation-stimulating activity on 3T3-L1 cells model, which indicated that compound 10 may possess well insulin-sensitizing activity.
authors.affiliation: School of Pharmacy, Guiyang Medical College, Guiyang 550004, China. tlei1974@hotmail.com
authors.forename: Lei
authors.initials: L
authors.lastname: Tang
authors.forename: Yu
authors.initials: Y
authors.lastname: Li
authors.forename: Juan-Hong
authors.initials: JH
authors.lastname: Yu
authors.forename: Yu-She
authors.initials: YS
authors.lastname: Yang
authors.forename: Ru-Yun
authors.initials: RY
authors.lastname: Ji
mesh_terms: D041721:3T3-L1 Cells; D000818:Animals; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000494:pharmacology; D015195:Drug Design; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology*; D051379:Mice
chemical_list: D001578:Benzopyrans; D007004:Hypoglycemic Agents; D007328:Insulin