Intentional ABO-incompatible lung transplantation.
We report on a case of intentional blood group incompatible lung transplantation. A blood group O cystic fibrosis patient was mechanically ventilated and put on interventional lung assist for severe respiratory decompensation. Since timely allocation of a blood group O donor lung was impossible, an AB deceased donor lung rescue allocation was accepted and the transplant performed using a pre-, peri- and postoperative antibody depletion protocol including plasmapheresis, ivIg administration, rituximab and immunoadsorption. Nine months after the transplant the patient is at home and well.
Strüber
M
M
Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany. strueber.martin@mh-hannover.de
Warnecke
G
G
Hafer
C
C
Goudeva
L
L
Fegbeutel
C
C
Fischer
S
S
Gottlieb
J
J
Avsar
M
M
Simon
A R
AR
Haverich
A
A
D000017:ABO Blood-Group System / Q000276:immunology*; D000327:Adsorption; D000328:Adult; D001787:Blood Group Incompatibility / Q000276:immunology; D003550:Cystic Fibrosis / Q000097:blood* / Q000628:therapy*; D005260:Female; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016040:Lung Transplantation / Q000379:methods*; D010956:Plasmapheresis; D012121:Respiration, Artificial; D016896:Treatment Outcome
D000017:ABO Blood-Group System; D007166:Immunosuppressive Agents