title: New triterpene glucosides from the roots of Rosa laevigata Michx.
abstract: Two new ursane-type triterpene glucosides, 2alpha,3alpha,24-trihydroxyurs-12,18-dien-28-oic acid beta-D-glucopyranosyl ester (1) and 2alpha,3alpha,23-trihydroxyurs-12,19(29)-dien-28-oic acid beta-D-glucopyranosyl ester (2), were isolated from the roots of Rosa laevigata, together with three known compounds: 2alpha,3beta,19alpha-trihydroxyurs-12-en-28-oic acid beta-Dglucopyranosyl ester (3), 2alpha,3alpha,19alpha-trihydroxyurs-12-en-28-oic acid beta-D-glucopyranosyl ester (4) and 2alpha,3beta,19alpha,23-tetrahydroxyurs-12-en-28-oic acid beta-D-glucopyranosyl ester (5). The structures of new compounds were established on the basis of detailed 1D and 2D NMR spectroscopic analyses. Compounds 2 and 5 exhibited modest in vitro antifungal activities against Candida albicans and C. krusei.
authors.affiliation: Guangxi Institute of Medicinal Plant, Nanning 530023, P.R. China.
authors.forename: Jing-Quan
authors.initials: JQ
authors.lastname: Yuan
authors.forename: Xin-Zhou
authors.initials: XZ
authors.lastname: Yang
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Miao
authors.forename: Chun-Ping
authors.initials: CP
authors.lastname: Tang
authors.forename: Chang-Qiang
authors.initials: CQ
authors.lastname: Ke
authors.forename: Ji-Bao
authors.initials: JB
authors.lastname: Zhang
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Ma
authors.forename: Yang
authors.initials: Y
authors.lastname: Ye
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002175:Candida / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D027826:Rosa / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D005960:Glucosides; D014315:Triterpenes