title: Osteo-odonto-keratoprosthesis in Japan.
abstract: Osteo-odonto-keratoprosthesis (OOKP) is a keratoprosthesis technique in which the patient's own tooth root is used to support an optical cylinder. It was invented by Strampelli in 1963 and modified and established by Falcinelli about 10 years later. This method is particularly useful for restoring sight in end-stage Stevens-Johnson syndrome (SJS) and ocular cicatricial pemphigoid (OCP). We started performing OOKP surgery in June 2003 supported by Dr Christopher Liu of Sussex Eye Hospital, Brighton, UK. Till now, we have performed 4 OOKP surgeries for end-stage SJS and OCP. We modified the original method by using artificial buccal mucous membranes to the bone and buccal mucous membrane defects for better wound healing. Case 1 was a 49-year-old woman (SJS), and the corrected visual acuity was 0.5 in 4 years 8 months. Case 2 was a 68-year-old woman (SJS), and the corrected visual acuity was 0.04 in 3 years 10 months. Case 3 was a 63-year-old man (SJS), and the corrected visual acuity was 0.1 in 3 years 2 months. Case 4 was a 71-year-old woman (OCP), and the corrected visual acuity was 0.04 in 1 year 3 months. Despite some minor optical cylinder troubles such as MRSA colonization, tilting, and buccal mucous coverage, their visual acuities were stable without any serious complications. It was demonstrated that OOKP is useful for visual rehabilitation and durable with minimum eye care for severe ocular surface diseases.
authors.affiliation: Department of Ophthalmology, Kinki University School of Medicine, Osaka-Sayama, Osaka, Japan. fukuda@ganka.med.kindai.ac.jp
authors.forename: Masahiko
authors.initials: M
authors.lastname: Fukuda
authors.forename: Suguru
authors.initials: S
authors.lastname: Hamada
authors.forename: Christopher
authors.initials: C
authors.lastname: Liu
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Shimomura
mesh_terms: D000328:Adult; D000368:Aged; D001705:Bioprosthesis; D005128:Eye Diseases / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007568:Jaw / Q000637:transplantation*; D008297:Male; D008875:Middle Aged; D010390:Pemphigoid, Benign Mucous Membrane / Q000503:physiopathology / Q000601:surgery*; D011184:Postoperative Period; D019736:Prostheses and Implants; D019919:Prosthesis Implantation / Q000379:methods; D013262:Stevens-Johnson Syndrome / Q000503:physiopathology / Q000601:surgery*; D014092:Tooth Root / Q000637:transplantation*; D016896:Treatment Outcome; D014792:Visual Acuity