title: A comparative study of inhibitory effect of human calprotectin on the growth of human gingival fibroblast and foreskin fibroblast.
abstract: In the present study, cytotoxicity effects of calprotectin on Human Gingival Fibroblast (HGF) and Human Foreskin Fibroblast (HFFF) were compared. For these evaluations, both cells were exposed to the different concentrations of calprotectin, for 24, 48 and 72 h. Cell proliferation was assessed using MTT assay. Our results revealed that growth inhibition of calprotectin on HGF and HFFF occur in a dose- and time-dependent manner. Results of this investigation showed that sensitivity of HGF cells to cytotoxic effect of human calprotectin was more than HFFF. The results indicate that drug resistance process is different for the two kinds of fibroblast cells.
authors.affiliation: Medical Proteomics Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Rezaei-Tavirani
authors.forename: Hakimeh
authors.initials: H
authors.lastname: Zali
authors.forename: Layla
authors.initials: L
authors.lastname: Nabai
authors.forename: Parviz
authors.initials: P
authors.lastname: Toossi
authors.forename: Farhad Malek
authors.initials: FM
authors.lastname: Zad
authors.forename: Pourkhoshbakht
authors.initials: P
authors.lastname: Yousof
mesh_terms: D002460:Cell Line; D049109:Cell Proliferation; D002470:Cell Survival; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000378:metabolism*; D052816:Foreskin / Q000378:metabolism*; D005881:Gingiva / Q000187:drug effects* / Q000378:metabolism*; D006801:Humans; D039841:Leukocyte L1 Antigen Complex / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008954:Models, Biological; D009504:Neutrophils / Q000378:metabolism; D012680:Sensitivity and Specificity; D013778:Tetrazolium Salts / Q000494:pharmacology; D013844:Thiazoles / Q000494:pharmacology; D013997:Time Factors
chemical_list: D039841:Leukocyte L1 Antigen Complex; D013778:Tetrazolium Salts; D013844:Thiazoles; C022616:thiazolyl blue