title: Progenitor migration to the thymus and T cell lineage commitment.
abstract: T cells developing in the thymus are ultimately derived from bone marrow (BM) hematopoietic stem cells (HSCs). An understanding of the developmental steps between HSCs and T cells is important for gaining insight into cancers of the T lineage, improving T cell reconstitution after BM transplantation, and also to help ameliorate immunological defects in aging. In this article, we summarize our current understanding of the inter-related fields of early T cell development and thymic aging, and briefly discuss major unresolved questions in this field.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA.
authors.forename: Arivazhagan
authors.initials: A
authors.lastname: Sambandam
authors.forename: J Jeremiah
authors.initials: JJ
authors.lastname: Bell
authors.forename: Benjamin A
authors.initials: BA
authors.lastname: Schwarz
authors.forename: Valerie P
authors.initials: VP
authors.lastname: Zediak
authors.forename: Anthony W
authors.initials: AW
authors.lastname: Chi
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Zlotoff
authors.forename: Shanthi Lakshmi
authors.initials: SL
authors.lastname: Krishnamoorthy
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Burg
authors.forename: Avinash
authors.initials: A
authors.lastname: Bhandoola
mesh_terms: D000375:Aging / Q000276:immunology; D000818:Animals; D019070:Cell Lineage / Q000276:immunology; D002465:Cell Movement / Q000276:immunology*; D016207:Cytokines / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000276:immunology; D006801:Humans; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology; D013950:Thymus Gland / Q000166:cytology* / Q000276:immunology
chemical_list: D016207:Cytokines