title: Transformation of p53-positive papillary thyroid carcinoma to anaplastic carcinoma of the liver following postoperative radioactive iodine-131 therapy.
abstract: Multiple liver metastases were incidentally detected in the lobe of the liver of an 81-year-old woman following total thyroidectomy and ablative radioactive iodine administration for the treatment of papillary thyroid carcinoma. A biopsy specimen taken from the metastatic liver tumor was histologically diagnosed as anaplastic carcinoma. Immunohistochemical staining for p53 was positive in both the primary tumor and liver biopsy specimens. We considered this to have been caused by anaplastic transformation from papillary thyroid carcinoma during treatment. We report a rare case of multiple liver metastases from a papillary thyroid carcinoma, which we believe to be the result of anaplastic transformation during postoperative radioactive iodine-131 therapy.
authors.affiliation: Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science.
authors.forename: Yumie
authors.initials: Y
authors.lastname: Takeshita
authors.forename: Toshinari
authors.initials: T
authors.lastname: Takamura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Minato
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Misu
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ando
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Yamashita
authors.forename: Hiroko
authors.initials: H
authors.lastname: Ikeda
authors.forename: Yasuni
authors.initials: Y
authors.lastname: Nakanuma
authors.forename: Shuichi
authors.initials: S
authors.lastname: Kaneko
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000708:Anaplasia; D002291:Carcinoma, Papillary / Q000378:metabolism* / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D016158:Genes, p53; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects*; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary*; D009154:Mutation; D011859:Radiography; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D013965:Thyroidectomy; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D007457:Iodine Radioisotopes; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53