The promiscuity of ARF interactions with the proteasome.
The tumor suppressor ARF is one of the most important oncogenic stress sensors in mammalian cells. Its effect is exerted through the interaction with different cellular partners, often resulting in their functional inactivation. This review focuses on the role played by the proteasome in ARF regulation of protein turnover and the function of most of its interacting partners. Specific proteasome components appear to be involved in the regulation of ARF turnover, bringing to light a complex network of interactions between ARF and the proteasome.
Pollice
Alessandra
A
Department of Structural and Functional Biology, University of Naples Federico II, Naples, Italy. apollice@unina.it
Vivo
Maria
M
La Mantia
Girolama
G
D000818:Animals; D006801:Humans; D051379:Mice; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D025803:Tumor Suppressor Protein p14ARF / Q000378:metabolism*
D011506:Proteins; D025803:Tumor Suppressor Protein p14ARF; D046988:Proteasome Endopeptidase Complex