title: Antiobesity effects of wild ginseng (Panax ginseng C.A. Meyer) mediated by PPAR-gamma, GLUT4 and LPL in ob/ob mice.
abstract: The antiobesity effect of wild ginseng (WG; Panax ginseng C.A. Meyer) in male obese leptin-deficient (B6.V-Lepob, 'ob/ob') mice was evaluated. WG was administered orally to mice at doses of 100 mg/kg and 200 mg/kg daily for 4 weeks. The WG-treated ob/ob mice showed a loss of body weight and a decrease in blood glucose levels compared with control mice. WG regulated the mRNA expression level especially, it increased peroxisome proliferators-activated receptors-gamma (PPAR-gamma) and lipoprotein lipase (LPL) in adipose tissue, as well as glucose transporter 4 (GLUT4) and insulin receptor (IR) in the skeletal muscle and liver. Taken together, these results suggest that WG may play a vital role in the antiobesity effect in ob/ob mice; this has importance in insulin sensitivity. This may prove to be of clinical importance in improving the management of obesity and related metabolic syndromes.
authors.affiliation: College of Veterinary Medicine, Kyungpook National University, Daegu, 702-701, Republic of Korea.
authors.forename: Mohammad Lalmoddin
authors.initials: ML
authors.lastname: Mollah
authors.forename: Gi-Sang
authors.initials: GS
authors.lastname: Kim
authors.forename: Hye-Kyung
authors.initials: HK
authors.lastname: Moon
authors.forename: Shin-Kyo
authors.initials: SK
authors.lastname: Chung
authors.forename: Yong-Pil
authors.initials: YP
authors.lastname: Cheon
authors.forename: Jong-Kuk
authors.initials: JK
authors.lastname: Kim
authors.forename: Kil-Soo
authors.initials: KS
authors.lastname: Kim
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects; D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D051275:Glucose Transporter Type 4 / Q000378:metabolism*; D020738:Leptin / Q000172:deficiency; D008071:Lipoprotein Lipase / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D018482:Muscle, Skeletal / Q000378:metabolism; D009765:Obesity / Q000188:drug therapy; D047495:PPAR gamma / Q000378:metabolism*; D005894:Panax / Q000737:chemistry*; D011972:Receptor, Insulin / Q000378:metabolism
chemical_list: D019440:Anti-Obesity Agents; D001786:Blood Glucose; D051275:Glucose Transporter Type 4; D020738:Leptin; D047495:PPAR gamma; C495693:Slc2a4 protein, mouse; D011972:Receptor, Insulin; D008071:Lipoprotein Lipase