[Progress in signal transduction pathways mediating effects of angiotensin II in endothelial cells].
Angiotensin II (Ang II) not only mediates the effects of vasoconstriction and blood pressure regulation, but is also implicated in inflammation, endothelial dysfunction, atherosclerosis, hypertension and congestive heart failure. Ang 1I activates pathways of MAPK, NADPH and ROS, non-receptor tyrosine kinases and receptor tyrosine kinases via AT1 receptor to produce various effects involved in regulation of endothelial functions, endothelial dysfunction and vascular inflammation response.
Han
Chun-Jie
CJ
Pharmacology Department of Xi'an Jiaotong University School of Medicine, Xi'an 710061, China.
Liu
Jun-Tian
JT
D000804:Angiotensin II / Q000378:metabolism*; D042783:Endothelial Cells / Q000378:metabolism*; D006801:Humans; D011945:Receptors, Angiotensin / Q000378:metabolism; D015398:Signal Transduction
D011945:Receptors, Angiotensin; D000804:Angiotensin II