title: Phylogenetic analysis of the species Theilovirus: emerging murine and human pathogens.
abstract: The Cardiovirus genus of the family Picornaviridae includes two distinct species, Encephalomyocarditis virus and Theilovirus. We now report the complete nucleotide sequences of three Theiler's murine encephalomyelitis virus (TMEV) strains (TO Yale, TOB15, and Vie 415HTR) and of Vilyuisk human encephalomyelitis virus (VHEV). This information, together with the recently reported sequences of divergent theiloviruses (Theiler's-like rat virus [TRV] and Saffold viruses 1 and 2 [SAFV-1 and SAFV-2]), enables an updated phylogenetic analysis as well as a reexamination of several gene products important in the pathogenesis of this emerging group of viruses. In the light of the known neurotropism of TMEV and the new human SAFV-1 and SAFV-2, the resulting data suggest the existence of theiloviruses that cause human central nervous system infections. Our phylogenetic analyses point to the classification of presently known theiloviruses into five types: TMEV, VHEV, TRV, SAFV-1, and SAFV-2.
authors.affiliation: Department of Neurology and Rehabilitation Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Liang
authors.forename: A S Manoj
authors.initials: AS
authors.lastname: Kumar
authors.forename: Morris S
authors.initials: MS
authors.lastname: Jones
authors.forename: Nick J
authors.initials: NJ
authors.lastname: Knowles
authors.forename: Howard L
authors.initials: HL
authors.lastname: Lipton
mesh_terms: D000818:Animals; D002213:Capsid; D002478:Cells, Cultured; D006224:Cricetinae; D018984:Epitopes, T-Lymphocyte; D016679:Genome, Viral; D006801:Humans; D051379:Mice; D010802:Phylogeny; D011995:Recombination, Genetic; D017945:Theilovirus / Q000145:classification* / Q000235:genetics; D020506:Untranslated Regions; D017361:Viral Nonstructural Proteins / Q000235:genetics
chemical_list: D018984:Epitopes, T-Lymphocyte; D020506:Untranslated Regions; D017361:Viral Nonstructural Proteins