title: Clinical features of primary sclerosing cholangitis with onset age above 50 years.
abstract: BACKGROUND
  Although there are two peaks in the age distribution of primary sclerosing cholangitis (PSC) in Japan, the clinical differences between the patients with an older or younger onset age have not been reported.
  
  
  METHODS
  We compared clinical features of 18 patients with onset age less than 50 years (younger group) and ten PSC patients with onset age above 50 years (older group).
  
  
  RESULTS
  An association with ulcerative colitis (UC) was recognized in six patients in the younger group and in one in the older group. High serum IgE (>170 IU/ml) was observed more frequently in the older than in the younger group (1/10 vs. 7/8, P = 0.0029). Mean serum IgM tended to be higher in the younger group (198 vs. 119 mg/dl, P = 0.083). More patients received liver transplantation or continuous bile drainage, or developed liver failure or cholangiocellular carcinoma in the younger than in the older group (11/18 vs. 1/10, P = 0.016).
  
  
  CONCLUSIONS
  Older PSC patients have higher IgE, possibly less association with UC, lower IgM, and a better prognosis. The pathogenesis of PSC may be different between older and younger patients.
authors.affiliation: Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Hirano
authors.forename: Minoru
authors.initials: M
authors.lastname: Tada
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Isayama
authors.forename: Yoko
authors.initials: Y
authors.lastname: Yashima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yagioka
authors.forename: Takashi
authors.initials: T
authors.lastname: Sasaki
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Kogure
authors.forename: Osamu
authors.initials: O
authors.lastname: Togawa
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Arizumi
authors.forename: Saburo
authors.initials: S
authors.lastname: Matsubara
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Nakai
authors.forename: Naoki
authors.initials: N
authors.lastname: Sasahira
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tsujino
authors.forename: Takao
authors.initials: T
authors.lastname: Kawabe
authors.forename: Masao
authors.initials: M
authors.lastname: Omata
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D002648:Child; D015209:Cholangitis, Sclerosing / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D003093:Colitis, Ulcerative / Q000150:complications; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D055815:Young Adult
chemical_list: D007073:Immunoglobulin E