title: Cytoskeletal regulation: coordinating actin and microtubule dynamics in membrane trafficking.
abstract: The Arp2/3 complex is essential for actin nucleation and filament elongation in a variety of intracellular processes. This functional versatility is exerted through the regulation of its activity by nucleation-promoting factors (NPFs). The discovery of a new NPF, WHAMM, reveals unexpected connections between the actin and microtubule cytoskeletons and membrane dynamics during ER-to-Golgi transport.
authors.affiliation: IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Disanza
authors.forename: Giorgio
authors.initials: G
authors.lastname: Scita
mesh_terms: D048248:Acanthamoeba castellanii / Q000502:physiology; D051376:Actin-Related Protein 2-3 Complex / Q000502:physiology; D000818:Animals; D002467:Cell Nucleus / Q000502:physiology*; D003599:Cytoskeleton / Q000502:physiology*; D004705:Endocytosis / Q000502:physiology; D006706:Homeostasis; D008870:Microtubules / Q000502:physiology*; D010587:Phagocytosis; D014741:Video Recording
chemical_list: D051376:Actin-Related Protein 2-3 Complex