Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues.
Our knowledge on tissue- and disease-specific functions of human genes is rather limited and highly context-specific. Here, we have developed a method for the comparison of mRNA expression levels of most human genes across 9,783 Affymetrix gene expression array experiments representing 43 normal human tissue types, 68 cancer types, and 64 other diseases. This database of gene expression patterns in normal human tissues and pathological conditions covers 113 million datapoints and is available from the GeneSapiens website.
Kilpinen
Sami
S
Medical Biotechnology, VTT Technical Research Centre and University of Turku, Itäinen pitkäkatu 4C, Turku, Finland. sami.k.kilpinen@helsinki.fi
Autio
Reija
R
Ojala
Kalle
K
Iljin
Kristiina
K
Bucher
Elmar
E
Sara
Henri
H
Pisto
Tommi
T
Saarela
Matti
M
Skotheim
Rolf I
RI
Björkman
Mari
M
Mpindi
John-Patrick
JP
Haapa-Paananen
Saija
S
Vainio
Paula
P
Edgren
Henrik
H
Wolf
Maija
M
Astola
Jaakko
J
Nees
Matthias
M
Hautaniemi
Sampsa
S
Kallioniemi
Olli
O
D030541:Databases, Genetic; D004194:Disease / Q000235:genetics; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D009928:Organ Specificity