title: Healing diabetic foot ulcers using cortical bone fenestration and cell therapy.
abstract: Chronic wounds with exposed bone present a challenge for clinicians. Without intact periosteum, cortical bone is relatively avascular and provides a poor base for wound healing and skin grafting. It has been shown that cortical bone fenestration and decortication can expedite wound healing in exposed calvarial bone. We present a case study where cortical bone fenestration and the subsequent application of human skin equivalent were used to heal a chronic wound of the lower extremity. We propose that this technique can facilitate the production of granulation tissue, and can aid the healing of chronic wounds of the lower extremities associated with exposed bone.
authors.affiliation: Division of Podiatric Surgery, Clara Maass Medical Center, Belleville, New Jersey, USA.
authors.forename: Wayne J
authors.initials: WJ
authors.lastname: Caputo
authors.forename: Charles D
authors.initials: CD
authors.lastname: Ganime
authors.forename: George
authors.initials: G
authors.lastname: Fahoury
authors.forename: Stephen
authors.initials: S
authors.lastname: Longobardi
mesh_terms: D000368:Aged; D003131:Combined Modality Therapy; D003646:Debridement / Q000379:methods*; D017719:Diabetic Foot / Q000175:diagnosis / Q000628:therapy*; D005260:Female; D006801:Humans; D010027:Osteotomy / Q000379:methods*; D016038:Skin Transplantation / Q000379:methods*; D016896:Treatment Outcome