title: Enhanced gamma interferon responses of mouse spleen cells following immunotherapy for tuberculosis relapse.
abstract: Gamma interferon responses of spleen cells in mice were examined during postchemotherapy relapse of intraperitoneally induced latent tuberculous infection. The mycobacterial extract RUTI, which prevented the relapse, significantly enhanced the immune responses to secreted and structural recombinant mycobacterial antigens, suggesting that RUTI-mediated protection was mediated by activated T cells.
authors.affiliation: Unitat de Tuberculosi Experimental, Department of Microbiology, Fundació Institut per a la Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Catalonia, Spain.
authors.forename: Olga
authors.initials: O
authors.lastname: Gil
authors.forename: Cristina
authors.initials: C
authors.lastname: Vilaplana
authors.forename: Evelyn
authors.initials: E
authors.lastname: Guirado
authors.forename: Jorge
authors.initials: J
authors.lastname: Díaz
authors.forename: Neus
authors.initials: N
authors.lastname: Cáceres
authors.forename: Mahavir
authors.initials: M
authors.lastname: Singh
authors.forename: Pere-Joan
authors.initials: PJ
authors.lastname: Cardona
mesh_terms: D000818:Animals; D007167:Immunotherapy / Q000379:methods*; D007371:Interferon-gamma / Q000096:biosynthesis*; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D051379:Mice; D012008:Recurrence; D013154:Spleen / Q000276:immunology*; D014376:Tuberculosis / Q000628:therapy*
chemical_list: D007371:Interferon-gamma