title: Successful treatment of lupoid cutaneous leishmaniasis with glucantime and topical trichloroacetic acid (a case report).
abstract: Lupoid leishmaniasis is a unique form of cutaneous leishmaniasis characterized by unusual clinical features and a chronic relapsing course, mostly caused by infection with Leishmania tropica. In this clinical form, 1-2 yr after healing of the acute lesion, new papules and nodules appear at the margin of the remaining scar. Herein, we describe a case of this clinical form that was resistant to 2 courses of treatments: systemic glucantime and then a combination therapy with allopurinol and systemic glucantime. However, marked improvement was seen after a combination therapy with topical trichloroacetic acid solution (50%) and systemic glucantime, and there were no signs of recurrence after 1 yr of follow-up.
authors.affiliation: Skin Diseases and Leishmaniasis Research Center, Department of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mohamad Ali
authors.initials: MA
authors.lastname: Nilforoushzadeh
authors.forename: Giti
authors.initials: G
authors.lastname: Sadeghian
authors.forename: Fariba
authors.initials: F
authors.lastname: Jaffary
authors.forename: Hengameh
authors.initials: H
authors.lastname: Ziaei
authors.forename: Liela
authors.initials: L
authors.lastname: Shirani-Bidabad
authors.forename: Parvin
authors.initials: P
authors.lastname: Mahzoni
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008536:Meglumine / Q000627:therapeutic use*; D000077485:Meglumine Antimoniate; D009942:Organometallic Compounds / Q000627:therapeutic use*; D014238:Trichloroacetic Acid / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000981:Antiprotozoal Agents; D009942:Organometallic Compounds; D014238:Trichloroacetic Acid; D008536:Meglumine; D000077485:Meglumine Antimoniate