title: Enantioselective regulation of a metal complex in reversible binding to serum albumin: dynamic helicity inversion signalled by circularly polarised luminescence.
abstract: The helicity of the (SSS)-Delta enantiomer of a terbium and europium(III) complex is inverted on reversible binding to 'drug site II' of serum albumin, signalled by a switch in its circularly polarised emission; no such behaviour occurs with the (RRR)-Lambda complexes, thereby defining a unique chiroptical probe of albumin binding.
authors.affiliation: Department of Chemistry, Durham University, South Road, Durham, UK DH1 3LE.
authors.forename: Craig P
authors.initials: CP
authors.lastname: Montgomery
authors.forename: Elizabeth J
authors.initials: EJ
authors.lastname: New
authors.forename: David
authors.initials: D
authors.lastname: Parker
authors.forename: Robert D
authors.initials: RD
authors.lastname: Peacock
mesh_terms: D000818:Animals; D001665:Binding Sites; D002417:Cattle; D005063:Europium / Q000737:chemistry*; D049449:Luminescence; D008163:Luminescent Measurements; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013725:Terbium / Q000737:chemistry*
chemical_list: D009942:Organometallic Compounds; D013725:Terbium; D012710:Serum Albumin, Bovine; D005063:Europium