Bioassay-guided isolation of antiplasmodial anacardic acids derivatives from the whole plants of Viola websteri Hemsl.
The petroleum ether extract of Viola websteri Hemsl. (Violaceae) was investigated for its activity against chloroquine-sensitive strains of Plasmodium falciparum using the parasite lactate dehydrogenase assay method. The main antiplasmodial principles, 6-(8'Z-pentadecenyl)-salicylic acid (1) and 6-(8'Z, 11'Z, 14'Z-heptadecatrienyl)-salicylic acid (2), have been isolated from V. websteri for the first time. This is the first report on the antiplasmodial activity of the compounds from V. websteri.
Lee
Sung Jae
SJ
Department of Integrative Medicine, College of Medicine, Korea University, Anam-dong 5ga, Seongbuk-gu, Seoul 136-705, South Korea.
Park
Won-Hwan
WH
Moon
Hyung-In
HI
D048729:Anacardic Acids / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D015394:Molecular Structure; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects*; D015800:Protozoan Proteins / Q000378:metabolism; D032413:Viola / Q000737:chemistry*
D048729:Anacardic Acids; D000962:Antimalarials; D010936:Plant Extracts; D015800:Protozoan Proteins; D007770:L-Lactate Dehydrogenase