Acute post-streptococcal glomerulonephritis associated with prolonged hypocomplementaemia.
The case of a 6-year-old boy who presented with acute post-streptococcal glomerulonephritis is reported. C3 levels and complement alternative pathway activity remained low for at least 10 months after presentation, before returning to normal. There was no evidence of other renal disease. This case highlights that hypocomplementaemia in acute post-streptococcal glomerulonephritis may persist for several months, and that prolonged hypocomplementaemia does not exclude this diagnosis.
Payne
D
D
Department of Immunology, Leicester Royal Infirmary, Leicester, UK. daniel.payne@uhl-tr.nhs.uk
Houtman
P
P
Browning
M
M
D000208:Acute Disease; D002648:Child; D003176:Complement C3 / Q000172:deficiency*; D003170:Complement Pathway, Alternative; D005921:Glomerulonephritis / Q000276:immunology* / Q000382:microbiology*; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D013290:Streptococcal Infections / Q000150:complications* / Q000276:immunology; D013297:Streptococcus pyogenes; D013995:Time
D003176:Complement C3