Kinetics of enzyme inhibition by active molluscicidal agents ferulic acid, umbelliferone, eugenol and limonene in the nervous tissue of snail Lymnaea acuminata.
Ferulic acid, umbelliferone (Ferula asafoetida), eugenol (Syzygium aromaticum) and limonene (Carum carvi) are active molluscicidal components that inhibited the activity of alkaline phosphatase and acetylcholinesterase in in vivo and in vitro exposure of Lymnaea acuminata. It was observed that ferulic acid, umbelliferone and eugenol are competitive and limonene is a competitive-non-competitive inhibitor of alkaline phosphatase. Ferulic acid and umbelliferone are competitive, whereas eugenol and limonene are competitive-non-competitive and uncompetitive inhibitors of acetylcholinesterase, respectively.
Kumar
Pradeep
P
Department of Zoology, DDU Gorakhpur University, Gorakhpur 273009, UP India.
Singh
V K
VK
Singh
D K
DK
D000110:Acetylcholinesterase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000037:antagonists & inhibitors; D000818:Animals; D003373:Coumaric Acids / Q000494:pharmacology; D053138:Cyclohexenes / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005054:Eugenol / Q000494:pharmacology; D007700:Kinetics; D000077222:Limonene; D008195:Lymnaea / Q000187:drug effects / Q000201:enzymology*; D008975:Molluscacides / Q000494:pharmacology*; D009417:Nerve Tissue / Q000187:drug effects / Q000201:enzymology*; D013729:Terpenes / Q000494:pharmacology; D014468:Umbelliferones / Q000494:pharmacology
D003373:Coumaric Acids; D053138:Cyclohexenes; D004791:Enzyme Inhibitors; D008975:Molluscacides; D013729:Terpenes; D014468:Umbelliferones; D005054:Eugenol; C031477:7-hydroxycoumarin; D000077222:Limonene; C004999:ferulic acid; D000110:Acetylcholinesterase; D000469:Alkaline Phosphatase