title: Epileptic seizures and EEG features in juvenile systemic lupus erythematosus.
abstract: BACKGROUND
  Juvenile systemic lupus erythematosus is more incident in female affecting different systems including the central nervous system. The aim of this study was to check the incidence of seizures and electroencephalographic features in these patients.
  
  
  METHODS
  It was analyzed all patients with juvenile systemic lupus erythematosus referred to the Pequeno Príncipe Hospital in Curitiba, PR, Brazil, in the year of 2007. The patients were submitted to EEG and subdivided into two groups according to the presence or absence of epileptic seizures. Mann-Whitney statistical test was used.
  
  
  RESULTS
  Forty-nine cases were included, there were 73.45% female, with an age between 3 and 28 years (micro=17.00 years; s=5.01 years). Seizures (13/26.50%) were the most frequent manifestation followed by headache (13/26.50%) and ischemic stroke (6/12.25%). Cerebral vasculites were the most frequent alteration in neuroimage. The abnormalities of EEG were characterized by asymmetry of the electric cerebral activity, diffuse disorganized background activity, focal epileptiform discharges in the right central-temporal region, generalized paroxysmal of 3 Hz spike-waves, and bursts of theta-delta slowness activity in the right parietal-occiptal region. The statistic analysis showed no significantly difference between age of onset of symptoms and the risk of seizures (p 0.675) as well as between time of the disease and the risk of seizures (p 0.436).
  
  
  CONCLUSIONS
  Neurologic manifestations, in special epileptic seizures, are frequent in systemic lupus erythematosus. Age of onset of symptoms and the time of disease did not increase the risk of epileptic seizures in this disease.
authors.affiliation: Serviço de Neurologia Infantil, Hospital Pequeno Príncipe, Curitiba, PR, Brazil.
authors.forename: Simone Carreiro
authors.initials: SC
authors.lastname: Vieira-Karuta
authors.forename: Izabella Celidônio Bertoldo
authors.initials: IC
authors.lastname: Silva
authors.forename: Paulo Breno Noronha
authors.initials: PB
authors.lastname: Liberalesso
authors.forename: Márcia
authors.initials: M
authors.lastname: Bandeira
authors.forename: Loris
authors.initials: L
authors.lastname: Janz
authors.forename: Alfredo
authors.initials: A
authors.lastname: Löhr
mesh_terms: D000293:Adolescent; D000328:Adult; D001938:Brazil; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D004827:Epilepsy / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008297:Male; D012307:Risk Factors; D018709:Statistics, Nonparametric; D055815:Young Adult