title: Optimization of perfusion imaging for acute cerebral ischemia: review of recent clinical trials and recommendations for future studies.
abstract: OBJECTIVE
  The use of thrombolytic agents and other forms of reperfusion therapy has provided a means to reverse ischemia and minimize the size of infarctions. The purpose of this review is to examine various clinical trials of reperfusion agents and address key imaging issues.
  
  
  CONCLUSIONS
  Advanced MRI and CT play a growing role in selection of patients for therapy. Numerous clinical trials have shed light on the efficacy of various reperfusion therapies; disparities in trial design have also left unanswered questions.
authors.affiliation: Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC 27710, USA.
authors.forename: James M
authors.initials: JM
authors.lastname: Provenzale
authors.forename: Max
authors.initials: M
authors.lastname: Wintermark
mesh_terms: D000208:Acute Disease; D002545:Brain Ischemia / Q000175:diagnosis* / Q000000981:diagnostic imaging; D002986:Clinical Trials as Topic; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*