Between transcription and translation: Re-defining RNA and regulation.
The diverse functional roles for RNA molecules in cells of the developing embryo have been an area of intense study in the last few years. Progress reported at the 49(th) Annual Drosophila Research Conference in San Diego, California highlighted many of the varied mechanistic activities for RNAs. In particular, talks at the 'RNA Biology' platform session provided a great deal of insight into the function of RNA transcripts and their associated protein complexes. The topics covered included: (1) a large-scale screen examining the localization of mRNAs during embryonic development, (2) mechanisms of mRNA transport in different cell types, (3) localization-dependent repression of mRNA translation and (4) the activity of the RNAi machinery in insulator-mediated chromatin structures. Our journey through the modern RNA world clearly indicates that we should be considering a much more expansive role for RNAs in molecular biology.
Ho
Margaret C W
MC
Biology Department, Harvey Mudd College, Claremont, California, USA.
Goetz
Sara E
SE
Schiller
Ben J
BJ
Allen
John M
JM
Drewell
Robert A
RA
D000818:Animals; D004330:Drosophila / Q000235:genetics* / Q000378:metabolism; D005786:Gene Expression Regulation; D008957:Models, Genetic; D009474:Neurons / Q000378:metabolism; D014176:Protein Biosynthesis; D034622:RNA Interference; D012326:RNA Splicing / Q000502:physiology; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism*; D014132:Trachea / Q000378:metabolism; D014158:Transcription, Genetic
D012333:RNA, Messenger