title: Acute effect of infection by adipogenic human adenovirus Ad36.
abstract: Human adenovirus Ad36 is causally and correlatively associated in animals and humans, respectively, with increased adiposity and altered metabolic profile. We inoculated rats with Ad36 or UV-inactivated Ad36, or mock-infected them. Four days later, Ad36-infected rats showed 23% greater epididymal fat pad weight and viral mRNA; the viral DNA could also be detected in tissues viz. the liver, brain, and adipose tissue. Intranasal or intra-peritoneal routes of viral inoculation showed similar tissue affinity. The serum cytokine response was markedly down-regulated. Ad36 acutely suppresses the systemic immune response and spreads widely. This information will help to determine Ad36 tissue tropism and its metabolic consequences.
authors.affiliation: Infections and Obesity Laboratory, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Pasarica
authors.forename: Scott
authors.initials: S
authors.lastname: Loiler
authors.forename: Nikhil V
authors.initials: NV
authors.lastname: Dhurandhar
mesh_terms: D000258:Adenovirus Infections, Human / Q000276:immunology / Q000378:metabolism* / Q000821:virology; D000260:Adenoviruses, Human / Q000276:immunology / Q000502:physiology*; D000273:Adipose Tissue / Q000276:immunology / Q000378:metabolism / Q000821:virology*; D000818:Animals; D001835:Body Weight; D016207:Cytokines / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D016207:Cytokines