CD8+ T suppressor cells and the ILT3 master switch.
Similar to helper and cytotoxic T cells, CD8(+) T suppressor cells (Ts) acquire antigen specificity via direct interaction with antigen-presenting cells (APC). They induce the upregulation of the inhibitory receptor immunoglobulin-like transcript (ILT)3 on professional and nonprofessional APC, rendering these cells tolerogenic and able to induce the differentiation of further waves of regulatory and suppressor T cells. This review sums up evidence that ILT3 is the centerpiece of CD8(+) Ts-driven suppression and acts as a master switch in the regulation of CD8(+) and CD4(+) T-cell responses to antigens in transplantation, autoimmunity, allergy, and cancer.
Vlad
George
G
Columbia University, Department of Pathology, New York, NY 10032, USA.
Cortesini
Raffaello
R
Suciu-Foca
Nicole
N
D000938:Antigen-Presenting Cells / Q000276:immunology; D015551:Autoimmunity; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D008562:Membrane Glycoproteins; D009369:Neoplasms / Q000276:immunology; D011956:Receptors, Cell Surface / Q000276:immunology*; D011971:Receptors, Immunologic; D023001:Transplantation Tolerance
C107907:LILRB4 protein, human; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic