Coadministration of oral levofloxacin with agents that impair absorption: impact on antibiotic resistance.
Coadministration of oral divalent or trivalent cation-containing compounds with oral fluoroquinolones may impair fluoroquinolone absorption. Among 3,134 patients who received a course of oral levofloxacin, coadministration was significantly associated with subsequent identification of a levofloxacin-resistant isolate. Strategies to curb the emergence of fluoroquinolone resistance should include avoiding the coadministration of divalent or trivalent cation-containing compounds and fluoroquinolone.
Cohen
Keira A
KA
Divisions of Infectious Diseases, Departments of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
Lautenbach
Ebbing
E
Weiner
Mark G
MG
Synnestvedt
Marie
M
Gasink
Leanne B
LB
D000042:Absorption; D000284:Administration, Oral; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology; D002412:Cations / Q000008:administration & dosage; D002413:Cations, Divalent / Q000008:administration & dosage; D004347:Drug Interactions; D024881:Drug Resistance, Bacterial; D004359:Drug Therapy, Combination; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000302:isolation & purification; D006095:Gram-Positive Cocci / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D064704:Levofloxacin; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology; D012307:Risk Factors
D000900:Anti-Bacterial Agents; D002412:Cations; D002413:Cations, Divalent; D064704:Levofloxacin; D015242:Ofloxacin