Towards quantitatively reproducible substrates for SERS.
There is a need for a method to facilitate the development of novel, reproducible colloidal surface-enhanced Raman scattering (SERS) substrates to encourage the use of SERS in applied studies. In this study we show for the first time that by using suitably designed SERS experiments in conjunction with multivariate analysis of variance (MANOVA), an objective assessment of colloidal SERS reproducibility can be made. This is demonstrated with the analyte cresyl violet, but could be extended to any analyte of interest for which reproducible SERS data are needed.
Jarvis
Roger M
RM
School of Chemistry, Manchester Interdisciplinary Biocentre, University of Manchester, 131 Princess Street, Manchester, UKM1 7DN. roger.jarvis@manchester.ac.uk
Johnson
Helen E
HE
Olembe
Emma
E
Panneerselvam
Arunkumar
A
Malik
Mohammad A
MA
Afzaal
Mohammad
M
O'Brien
Paul
P
Goodacre
Royston
R
D000042:Absorption; D048588:Benzoxazines; D003102:Colloids; D003627:Data Interpretation, Statistical; D004492:Edetic Acid; D006046:Gold; D053768:Metal Nanoparticles; D010078:Oxazines; D012834:Silver; D013059:Spectrum Analysis, Raman / Q000379:methods*; D013499:Surface Properties
D048588:Benzoxazines; D003102:Colloids; D010078:Oxazines; C028911:cresyl violet; D012834:Silver; D006046:Gold; D004492:Edetic Acid