Synthesis and studies on antidepressant and anticonvulsant activities of some 3-(2-thienyl)pyrazoline derivatives.
In this study, the synthesis of twelve 3-(2-thienyl)pyrazoline derivatives are described. The structures of all compounds were confirmed by UV, IR, (1)H-NMR, mass spectral data, and microanalyses. In the pharmacological studies, antidepressant and anticonvulsant activities of these compounds have been screened. The antidepressant activities of the compounds were investigated by Porsolt's behavioral despair test (forced swimming) on albino mice and compared with tranylcypromine. Among the compounds examined, the compounds 9 and 12 showed significant antidepressant activity. Anticonvulsant activities of the compounds were determined by maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (metrazol) (scMet.) tests, neurotoxicities were determined by rotarod toxicity test on albino mice. Compound 8 was found to be protective against MES in the range of 30-300 mg/kg dose levels at four hours. None of the synthesized compounds showed neurotoxicity at 30-300 mg/kg dose levels.
Ozdemir
Zuhal
Z
Hacettepe University Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara, Turkey.
Kandilci
H Burak
HB
Gumusel
Bulent
B
Calis
Unsal
U
Bilgin
A Altan
AA
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D000928:Antidepressive Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D051379:Mice; D015394:Molecular Structure; D011720:Pyrazoles / Q000009:adverse effects / Q000138:chemical synthesis / Q000494:pharmacology*; D012640:Seizures / Q000188:drug therapy; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship
D000927:Anticonvulsants; D000928:Antidepressive Agents; D011720:Pyrazoles