title: [Clinical observation of bushen er'xian decoction in treating premature ovarian failure].
abstract: OBJECTIVE
  To observe the therapeutic effect and immune regulatory mechanism of Bushen Er'xian Decoction (BED) on patients with premature ovarian failure (POF).
  
  
  METHODS
  Sixty patients with POF were randomly assigned to two groups in the ratio of 2:1, the 40 in the treatment group were treated with BED and the 20 in the control group were treated with artificial menstrual cycle therapy. The clinical efficacy was observed and the changes of serum reproductive hormone and T lymphocytes before and after treatment were observed.
  
  
  RESULTS
  The total effective rate in the treatment group was 72.5% (29/40 cases), which was higher than that in the control group, 45.0% (9/20 cases, P < 0.05). Serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) decreased and estradiol (E2) increased in both groups after treatment (P <0.05), but the level of FSH was lower in the treatment group than in the control group (22.57 +/- 12.49 IU/L vs 31.10 +/- 14.50 IU/L, P <0.05). CD4 and CD4/CD8 increased, CD8 decreased in the treatment group after treatment, showing significant difference as compared with those before treatment and with those in the control group after treatment (P <0.01).
  
  
  CONCLUSIONS
  BED is favourable for improving POF, being a good remedy with better clinical efficacy.
authors.affiliation: Women's Hospital, School of Medicine, Zhejiang University, Hangzhou. luxiaonan888@tom.com
authors.forename: Xiao-nan
authors.initials: XN
authors.lastname: Lu
authors.forename: Xiang-Rong
authors.initials: XR
authors.lastname: Xu
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Lin
mesh_terms: D000328:Adult; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008875:Middle Aged; D016649:Primary Ovarian Insufficiency / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal; C517980:er-xian decoction; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone