Primary hepatic marginal zone B cell lymphoma of mucosa-associated lymphoid tissue type: case report and review of the literature.
A primary hepatic marginal zone B cell lymphoma of mucosa-associated lymphoid tissue (MALT) is very rare. We found a solitary mass 27 mm in size in the left lobe of the liver of a 58-year-old Japanese man with a history of hepatitis-C infection. Based on the results of imaging studies, the tumor was diagnosed as a hepatocellular carcinoma (HCC). The left lobe of the liver was lobectomized and microscopic findings showed that the tumor was a hepatic MALT lymphoma, while immunohistochemistry showed it to be positive for CD20 and CD79a. In a fluorodeoxyglucose-positron emission tomography examination integrated with computed tomography scanning (FDG-PET CT) before surgery, the tumor was revealed to have a high standardized uptake value (SUV) for FDG. The patient received chemotherapy after surgery. To the best of our knowledge, 45 cases had been reported with a mean age for all patients of 61.4 years. The pathogenesis remains unclear, although half of the patients had a past history of chronic inflammatory liver disease. Surgical resection was performed in most cases and some patients received postoperative chemotherapy or radiotherapy. The clinicopathologic characteristics and management of this extremely rare disease are also discussed.
Doi
Hirokazu
H
Department of Gastroenterology, Ehime Prefectural Central Hospital, Ehime, 790-0024, Japan. hirokazud@me.pikara.ne.jp.
Horiike
Norio
N
Department of Gastroenterology, Ehime Prefectural Central Hospital, Ehime, 790-0024, Japan.
Hiraoka
Atsushi
A
Department of Gastroenterology, Ehime Prefectural Central Hospital, Ehime, 790-0024, Japan.
Koizumi
Yohei
Y
Department of Gastroenterology, Ehime Prefectural Central Hospital, Ehime, 790-0024, Japan.
Yamamoto
Yasunori
Y
Department of Gastroenterology, Ehime Prefectural Central Hospital, Ehime, 790-0024, Japan.
Hasebe
Aki
A
Department of Gastroenterology, Ehime Prefectural Central Hospital, Ehime, 790-0024, Japan.
Ichikawa
Soichi
S
Department of Gastroenterology, Ehime Prefectural Central Hospital, Ehime, 790-0024, Japan.
Yano
Makoto
M
Department of Gastroenterology, Ehime Prefectural Central Hospital, Ehime, 790-0024, Japan.
Miyamoto
Yasunao
Y
Department of Gastroenterology, Ehime Prefectural Central Hospital, Ehime, 790-0024, Japan.
Ninomiya
Tomoyuki
T
Department of Gastroenterology, Ehime Prefectural Central Hospital, Ehime, 790-0024, Japan.
Ishimaru
Yoshihiro
Y
Department of Radiology, Ehime Prefectural Central Hospital, Ehime, Japan.
Miyagawa
Masao
M
Department of Radiology, Ehime Prefectural Central Hospital, Ehime, Japan.
Takamura
Kazuhito
K
Department of Surgery, Ehime Prefectural Central Hospital, Ehime, Japan.
Kawasaki
Hideki
H
Department of Surgery, Ehime Prefectural Central Hospital, Ehime, Japan.
Kozuka
Teruhiko
T
Department of Hematology, Ehime Prefectural Central Hospital, Ehime, Japan.
Maeda
Toshiharu
T
Department of Medical Laboratory, Ehime Prefectural Central Hospital, Ehime, Japan.
Yoshino
Tadashi
T
Department of Pathology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan.
D018951:Antigens, CD20; D044466:Asian People; D051925:CD79 Antigens; D006526:Hepatitis C / Q000473:pathology; D006801:Humans; D007564:Japan; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy*; D018442:Lymphoma, B-Cell, Marginal Zone / Q000378:metabolism / Q000473:pathology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods
D018951:Antigens, CD20; D051925:CD79 Antigens; C497881:CD79A protein, human