Update on the role of vitamin K in skeletal health.
A protective role for vitamin K in bone health has been suggested based on its role as an enzymatic cofactor. In observational studies, vitamin K insufficiency is generally associated with lower bone mass and increased hip fracture risk. However, these findings are not supported in randomized controlled trials (RCT) of phylloquinone (vitamin K(1)) supplementation and bone loss at the hip in the elderly. This suggests that increased vegetable and legume intakes may simultaneously improve measures of vitamin K status and skeletal health, even though the mechanisms underlying these improvements may be independent of each other. Menaquinone-4 (vitamin K(2)), when given at pharmacological doses, appears to protect against fracture risk and bone loss at the spine. However, there are emerging data that suggest the efficacy of vitamin K supplementation on bone loss is inconclusive.
Shea
M Kyla
MK
Vitamin K Laboratory, USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.
Booth
Sarah L
SL
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D001842:Bone and Bones / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis; D016032:Randomized Controlled Trials as Topic; D014812:Vitamin K / Q000502:physiology*; D010837:Vitamin K 1 / Q000008:administration & dosage; D014813:Vitamin K Deficiency
D014812:Vitamin K; D010837:Vitamin K 1