title: Centenarian offspring: start healthier and stay healthier.
abstract: OBJECTIVE
  To assess the relative incidence of age-related diseases in a group of centenarian offspring who have thus far been considered to be predisposed to "healthy" aging.
  
  
  METHODS
  Longitudinal study.
  
  
  METHODS
  Nationwide sample.
  
  
  METHODS
  Four hundred forty centenarian offspring and 192 referent cohort subjects who met inclusion criteria of having initial and follow-up health questionnaire data available. Median age of both cohorts was 72 at the initial health questionnaire.
  
  
  METHODS
  Initial health questionnaires were collected from 1997 to 2006. Follow-up questionnaires were collected from 2004 to 2007. The mean period of follow-up was 3.5+/-1.7 years for the centenarian offspring and 3.9+/-2.2 years for the referent cohort.
  
  
  RESULTS
  During the follow-up period, centenarian offspring had a 78% lower risk of myocardial infarction (P<.04), 83% lower risk of stroke (P<.004), and 86% lower risk of developing diabetes mellitus (P<.005) than the referent cohort. There were no significant differences in new onset of other age-related diseases. Additionally, centenarian offspring were 81% less likely to die (P<.01) than the referent cohort during the follow-up.
  
  
  CONCLUSIONS
  These findings suggest that centenarian offspring retain some important cardiovascular advantages over time over similarly aged referent cohort subjects. These findings reinforce the notion that there may be physiological reasons that longevity runs in families and that centenarian offspring are more likely to age in better cardiovascular health and with a lower mortality than their peers.
authors.affiliation: Department of Epidemiology, School of Public Health, Boston University, Boston, Massachusetts, USA.
authors.forename: Emily R
authors.initials: ER
authors.lastname: Adams
authors.forename: Vikki G
authors.initials: VG
authors.lastname: Nolan
authors.forename: Stacy L
authors.initials: SL
authors.lastname: Andersen
authors.forename: Thomas T
authors.initials: TT
authors.lastname: Perls
authors.forename: Dellara F
authors.initials: DF
authors.lastname: Terry
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002908:Chronic Disease / Q000453:epidemiology*; D005260:Female; D006304:Health Status; D006306:Health Surveys; D006801:Humans; D015994:Incidence; D008136:Longevity / Q000235:genetics*; D008137:Longitudinal Studies; D008297:Male