Structural elucidation of a PDE-5 inhibitor detected as an adulterant in a health supplement.
A PDE-5 inhibitor was detected and isolated from a health supplement claimed to be a preparation of fresh oyster extracts and be able to promote and support healthy sexual function and endurance, etc. The structure of this PDE-5 inhibitor was elucidated using LC-UV, LC-TOF-MS, MS-MS, IR spectroscopy, and 2D NMR. It was characterized as 8-(2-(4-(hydroxymethyl)piperidin-1-yl)benzylamino)-3-ethyl-1H-imidazo[4,5-g]quinazoline-2(3H)-thione, a compound reported to be a PDE-5 inhibitor.
Ge
Xiaowei
X
Center for Analytical Sciences, Health Science Authority, 11 Outram Road, Singapore 169078, Singapore.
Low
Min-Yong
MY
Zou
Peng
P
Lin
Li
L
Yin
Sharon Oh Sze
SO
Bloodworth
Bosco C
BC
Koh
Hwee-Ling
HL
D002214:Capsules; D002853:Chromatography, Liquid / Q000379:methods; D019587:Dietary Supplements / Q000032:analysis*; D004340:Drug Contamination; D007172:Erectile Dysfunction / Q000178:diet therapy*; D006801:Humans; D007093:Imidazoles / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D013058:Mass Spectrometry / Q000379:methods; D015394:Molecular Structure; D010726:Phosphodiesterase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D011799:Quinazolines / Q000737:chemistry* / Q000302:isolation & purification; D013056:Spectrophotometry, Ultraviolet / Q000379:methods
D002214:Capsules; D007093:Imidazoles; D010726:Phosphodiesterase Inhibitors; D011799:Quinazolines; C443180:KF 31327