title: The CYPome (Cytochrome P450 complement) of Aspergillus nidulans.
abstract: The cytochromes P450 (CYPs) are found in all biological kingdoms and genome sequencing projects continue to reveal an ever increasing number. The principle aim of this paper is to identify the complete CYPome of Aspergillus nidulans from the genome sequence version AN.3 deposited at the Broad institute, assign the appropriate CYP nomenclature and define function where possible. The completed analysis revealed a total of 111 CYP genes, 3 of which were previously unknown and 8 pseudogenes, representing 89CYP families, 21 of which are unique. We have identified 28 potential gene clusters associated with one or more CYP genes and discussed those with putative PKS and NRPS associated function. The chromosomal location of the genes, predicted cellular location of the proteins and possible function(s) are discussed.
authors.affiliation: Institute of Life Sciences, 6 School of Medicine, Swansea University, Singleton Park, Swansea SA2, 8PP, UK. D.Kelly@swansea.ac.uk
authors.forename: Diane E
authors.initials: DE
authors.lastname: Kelly
authors.forename: Nada
authors.initials: N
authors.lastname: Krasevec
authors.forename: Jonathan
authors.initials: J
authors.lastname: Mullins
authors.forename: David R
authors.initials: DR
authors.lastname: Nelson
mesh_terms: D001233:Aspergillus nidulans / Q000235:genetics*; D019295:Computational Biology; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D005656:Fungal Proteins / Q000235:genetics*; D005800:Genes, Fungal; D005810:Multigene Family
chemical_list: D005656:Fungal Proteins; D003577:Cytochrome P-450 Enzyme System