title: Eight years' experience with high-intensity focused ultrasonography for treatment of localized prostate cancer.
abstract: OBJECTIVE
  To report on the long-term results of high-intensity focused ultrasonography (HIFU) in the treatment of localized prostate cancer.
  
  
  METHODS
  Patients with clinical Stage T1-T2N0M0, biopsy-proven, localized prostate cancer, with a serum prostate-specific antigen (PSA) level of <or=20 ng/mL, Gleason score of <or=7, and with no previous curative prostate cancer treatment, were included. All patients underwent HIFU using the Ablatherm device and were required to have a minimal follow-up of 3 years after the last HIFU session to be included in this analysis. Follow-up included PSA measurement and biopsy performed 3-6 months after treatment and in conjunction with an increasing PSA level. Biochemical failure was defined according to the Phoenix definition (PSA nadir + 2 ng/mL). In determining the disease-free survival rate, treatment was considered to have failed if any of the following occurred: biochemical failure, positive biopsy findings, or the initiation of salvage treatment.
  
  
  RESULTS
  The study included 163 patients. Within the 4.8 +/- 1.2 years of follow-up, no patient died of prostate cancer. Of the 163 patients, 86.4% achieved a PSA nadir of <1 ng/mL and 92.7% had negative post-treatment biopsy findings. The actuarial biochemical survival rate at 5 years was 75%. The actuarial disease-free survival rate at 5 years was 66%, with salvage treatment initiated for 12% of the patients. On multivariate analysis, the pretreatment PSA level was the only statistically significant predictive factor of recurrence (P = .005).
  
  
  CONCLUSIONS
  The results after long-term follow-up have indicated that HIFU is an efficient and safe treatment for patients with localized prostate cancer.
authors.affiliation: Department of Urology, University of Regensburg, St Josef's Hospital, Regensburg, Germany. blana@web.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Blana
authors.forename: Sebastian
authors.initials: S
authors.lastname: Rogenhofer
authors.forename: Roman
authors.initials: R
authors.lastname: Ganzer
authors.forename: Jens-Claudio
authors.initials: JC
authors.lastname: Lunz
authors.forename: Martin
authors.initials: M
authors.lastname: Schostak
authors.forename: Wolf F
authors.initials: WF
authors.lastname: Wieland
authors.forename: Bernhard
authors.initials: B
authors.lastname: Walter
mesh_terms: D000368:Aged; D001706:Biopsy; D018572:Disease-Free Survival; D006801:Humans; D008297:Male; D008495:Medical Oncology / Q000379:methods; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy*; D012008:Recurrence; D016879:Salvage Therapy; D016896:Treatment Outcome; D014463:Ultrasonography; D036761:Ultrasound, High-Intensity Focused, Transrectal / Q000379:methods*