title: The 3020insC NOD2 gene mutation in patients with ovarian cancer.
abstract: OBJECTIVE
  There is an increasing evidence that genetic factors play a role in the etiology of malignant tumors. Mutations of BRCA1 and BRCA2 genes are responsible for an increased risk of ovarian cancer. The role of mutations in NOD2 gene in this type of neoplasm is still under investigation.
  
  
  OBJECTIVE
  The aim of this study was to determine: 1. incidence of NOD 2 3020insC constitutional mutation in a group of consecutive women with ovarian cancer, 2. risk of developing ovarian cancer in patients with NOD2 gene mutation, 3. clinical and pathological features of ovarian cancer in NOD2 gene mutation carriers.
  
  
  METHODS
  Clinical and pathological data were collected from 257 non-selected patients with primary epithelial ovarian cancer. The researches identified NOD2 3020insC gene mutation. On the basis of patient source documentation we obtained the data concerning the age of patients at diagnosis, histopathological recognition, FIGO stage and morphological grade G.
  
  
  RESULTS
  19 out of 257 women were identified with germ-line 3020insC mutation of NOD2 gene (7.39%). An increased risk of ovarian cancer in NOD2 mutation carriers was not revealed (OR=1.01; p=0.928; 95% Cl=0.61-1.66). The mean age at diagnosis of patients with NOD2 mutation was 54.8 (SD=9.9), while for non-carriers it was 53.2 (SD=10.2). The difference between these frequencies was statistically irrelevant (p=0.550). Clinical and pathological profile of ovarian cancer was made. We assessed the following features: age at disease onset, histopathology, FIGO stage and morphological grade G. For NOD2 mutation carriers no statistically significant features of ovarian cancer were revealed.
  
  
  CONCLUSIONS
  1. Despite high frequency of constitutional mutations occurrence in NOD2 gene in women with ovarian cancer, genetic testing seem not to be justified in all women diagnosed with this disease. 2. Due to a lack of increased risk of ovarian cancer in NOD2 gene mutation carriers, proceedings for them may not differ from recommendations for general population. 3. It is difficult to determine characteristic clinical and pathological features of ovarian cancer for NOD2 gene mutation carriers.
authors.affiliation: Department of Gynecology, Obstetrics and Gynecological Oncology, Division of Gynecologic Oncology, Poznań University of Medical Sciences, Poland. piotrek.magnowski@poczta.fm
authors.forename: Piotr
authors.initials: P
authors.lastname: Magnowski
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Medrek
authors.forename: Magdalena
authors.initials: M
authors.lastname: Magnowska
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Stawicka
authors.forename: Helena
authors.initials: H
authors.lastname: Kedzia
authors.forename: Bohdan
authors.initials: B
authors.lastname: Górski
authors.forename: Jan
authors.initials: J
authors.lastname: Lubiński
authors.forename: Marek
authors.initials: M
authors.lastname: Spaczyński
mesh_terms: D000328:Adult; D000483:Alleles; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005820:Genetic Testing / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000453:epidemiology* / Q000235:genetics*; D053473:Nod2 Signaling Adaptor Protein; D010051:Ovarian Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D011044:Poland / Q000453:epidemiology
chemical_list: C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein