Antiobesity effects of wild ginseng (Panax ginseng C.A. Meyer) mediated by PPAR-gamma, GLUT4 and LPL in ob/ob mice.
The antiobesity effect of wild ginseng (WG; Panax ginseng C.A. Meyer) in male obese leptin-deficient (B6.V-Lepob, 'ob/ob') mice was evaluated. WG was administered orally to mice at doses of 100 mg/kg and 200 mg/kg daily for 4 weeks. The WG-treated ob/ob mice showed a loss of body weight and a decrease in blood glucose levels compared with control mice. WG regulated the mRNA expression level especially, it increased peroxisome proliferators-activated receptors-gamma (PPAR-gamma) and lipoprotein lipase (LPL) in adipose tissue, as well as glucose transporter 4 (GLUT4) and insulin receptor (IR) in the skeletal muscle and liver. Taken together, these results suggest that WG may play a vital role in the antiobesity effect in ob/ob mice; this has importance in insulin sensitivity. This may prove to be of clinical importance in improving the management of obesity and related metabolic syndromes.
Mollah
Mohammad Lalmoddin
ML
College of Veterinary Medicine, Kyungpook National University, Daegu, 702-701, Republic of Korea.
Kim
Gi-Sang
GS
Moon
Hye-Kyung
HK
Chung
Shin-Kyo
SK
Cheon
Yong-Pil
YP
Kim
Jong-Kuk
JK
Kim
Kil-Soo
KS
D000273:Adipose Tissue / Q000187:drug effects; D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D051275:Glucose Transporter Type 4 / Q000378:metabolism*; D020738:Leptin / Q000172:deficiency; D008071:Lipoprotein Lipase / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D018482:Muscle, Skeletal / Q000378:metabolism; D009765:Obesity / Q000188:drug therapy; D047495:PPAR gamma / Q000378:metabolism*; D005894:Panax / Q000737:chemistry*; D011972:Receptor, Insulin / Q000378:metabolism
D019440:Anti-Obesity Agents; D001786:Blood Glucose; D051275:Glucose Transporter Type 4; D020738:Leptin; D047495:PPAR gamma; C495693:Slc2a4 protein, mouse; D011972:Receptor, Insulin; D008071:Lipoprotein Lipase