title: Saccharomyces kluyveri as a model organism to study pyrimidine degradation.
abstract: The yeast Saccharomyces kluyveri (Lachancea kluyveri), a far relative of Saccharomyces cerevisiae, is not a widely studied organism in the laboratory. However, significant contributions to the understanding of nucleic acid precursors degradation in eukaryotes have been made using this model organism. Here we review eukaryotic pyrimidine degradation with emphasis on the contributions made with S. kluyveri and how this increases our understanding of human disease. Additionally, we discuss the possibilities and limitations of this nonconventional yeast as a laboratory organism.
authors.affiliation: Department of Cell and Organism Biology, Lund University, Lund, Sweden.
authors.forename: Halfdan
authors.initials: H
authors.lastname: Beck
authors.forename: Doreen
authors.initials: D
authors.lastname: Dobritzsch
authors.forename: Jure
authors.initials: J
authors.lastname: Piskur
mesh_terms: D000581:Amidohydrolases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D000818:Animals; D005057:Eukaryotic Cells / Q000378:metabolism*; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D009694:Nucleic Acid Precursors / Q000378:metabolism*; D011743:Pyrimidines / Q000378:metabolism*; D012440:Saccharomyces / Q000145:classification* / Q000201:enzymology* / Q000235:genetics / Q000378:metabolism
chemical_list: D005656:Fungal Proteins; D009694:Nucleic Acid Precursors; D011743:Pyrimidines; D000581:Amidohydrolases; C021590:beta-ureidopropionase; C020047:dihydropyrimidinase; C030986:pyrimidine