title: [Preparation and quality evaluation of intravenous tanshinone II (A) emulsion].
abstract: OBJECTIVE
  To prepare and evaluate an intravenous emulsion of tanshinone II(A).
  
  
  METHODS
  Soybean phospholipid mixing with poloxamer 188 was used as emulsifier. Oleic acid and glycerol were used as co-emulsifier and isoosmotic adjusting agent, respectively. The coarse emulsion was first prepared and following homogenization was carried out for the coarse emulsion by using a high pressure homogenizer.
  
  
  RESULTS
  The average diameter of the prepared tanshinone II (A) emulsion was 211 nm with a zeta potential of -32. 1 mV. There had no changes of diameter, zeta potential, pH value, content and physical appearance for the tanshinone II (A) emulsion stored at 25 degrees C away from light during one year.
  
  
  CONCLUSIONS
  The physicochemical properties of the prepared tanshinone II (A) emulsion was stable, which could meet the requirements of intravenous administration.
authors.affiliation: West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liang
authors.forename: Sheng-Jun
authors.initials: SJ
authors.lastname: Mao
authors.forename: Zong-Ning
authors.initials: ZN
authors.lastname: Yin
authors.forename: Hui
authors.initials: H
authors.lastname: Jin
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Ting
authors.initials: T
authors.lastname: Chu
mesh_terms: D045784:Abietanes; D002498:Centrifugation; D004355:Drug Stability; D004356:Drug Storage; D004655:Emulsions; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous; D010316:Particle Size; D010616:Phenanthrenes / Q000008:administration & dosage* / Q000737:chemistry*; D011786:Quality Control; D013696:Temperature
chemical_list: D045784:Abietanes; D004655:Emulsions; D010616:Phenanthrenes; C021751:tanshinone