title: [Use of urine lead level as an exposure indicator and its relationship to blood lead].
abstract: The aim of this work was to verify whether there are statistically significant correlation between the concentrations of lead in blood (Pb-B) and urine (Pb-U). Electrothermal atomic absorption spectrometry was used in the determination of lead concentration in biological material. Venous blood and spot urine were collected from workers occupationally exposed (95), adults (130) and children up to 15 years old (22) environmentally exposed. After a test showing significant differences between Pb-U and the three categories previously determined, cutting points for Pb-U were established to predict Pb-B values by the ROC curve. Thus, it is expected that Pb-B is lower than 10 microg.dL-(1) with Pb-U up to 0.55 microg.dL-(1), whereas lead levels in blood below 27.6 microg.dL-(1) are expected when the amount of the metal in urine is lower than 2.05 microg.dL-(1). So, urine can be used to replace blood for the assessment of the occupational exposure to lead. However, caution is advised in the case of environmental exposure, since urinary lead should be used just as an estimation of the metal content in blood.
authors.affiliation: Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil. fmoreira@ensp.fiocruz.br
authors.forename: Maria de Fátima Ramos
authors.initials: Mde F
authors.lastname: Moreira
authors.forename: Eduardo Borba
authors.initials: EB
authors.lastname: Neves
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis; D006305:Health Status Indicators; D006801:Humans; D007854:Lead / Q000097:blood* / Q000652:urine*; D007855:Lead Poisoning / Q000097:blood / Q000175:diagnosis* / Q000652:urine; D009784:Occupational Diseases / Q000097:blood / Q000175:diagnosis* / Q000652:urine; D016273:Occupational Exposure / Q000032:analysis*; D012372:ROC Curve; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D055815:Young Adult
chemical_list: D015415:Biomarkers; D007854:Lead