title: Prophylaxis with recombinant-activated factor VII (rFVIIa) for minimally invasive surgery in a patient with congenital factor VII deficiency: a case report with a single-low dose of rFVIIa.
abstract: Congenital factor VII deficiency is a rare autosomal-recessive disorder and surgery in patients with factor VII deficiency has been reported to be endangered by intraoperative or postoperative bleeding, unless a replacement therapy is used. In this paper, we report a successful prophylaxis with single and low dose rFVIIa (12.5 microg kg(-1)) in a 22-year-old homozygote factor VII deficient patient who underwent laparoscopic gynecologic surgery. Minimally invasive surgeries, such as laparoscopic surgery, could be safely performed in patients with congenital factor VII using single and low dose rFVIIa combined with vigilant clinical observation and laboratory examination.
authors.affiliation: Department of Anesthesiology and Intensive Care, Ankara University Medical Faculty, Cayyolu, Ankara, Turkey. draliabbas@yahoo.com
authors.forename: Ali Abbas
authors.initials: AA
authors.lastname: Yilmaz
authors.forename: Saban
authors.initials: S
authors.lastname: Yalcin
authors.forename: Hacer
authors.initials: H
authors.lastname: Serdaroglu
authors.forename: Murat
authors.initials: M
authors.lastname: Sonmezer
authors.forename: Asuman
authors.initials: A
authors.lastname: Uysalel
mesh_terms: D016063:Blood Loss, Surgical / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005168:Factor VII Deficiency / Q000097:blood / Q000151:congenital / Q000188:drug therapy*; D015942:Factor VIIa / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D019060:Minimally Invasive Surgical Procedures / Q000379:methods; D011994:Recombinant Proteins / Q000008:administration & dosage; D055815:Young Adult
chemical_list: D011994:Recombinant Proteins; C103587:recombinant FVIIa; D015942:Factor VIIa