Coffee intake and CYP1A2*1F genotype predict breast volume in young women: implications for breast cancer.
As breast volume may be associated with heart cancer risk, we studied the relationship between breast volume, CYP1A2*1F and coffee intake. Among healthy premenopausal non-hormone users, 3+ cups per day was associated with lower volume only in C-allele carriers (P(interaction)=0.02), which is consistent with reports that coffee protects only C-allele carriers against breast cancer.
Jernström
H
H
Department of Oncology, Clinical Sciences, Lund University, Barngatan 2B, SE-221 85 Lund, Sweden. helena.jernstrom@med.lu.se
Henningson
M
M
Johansson
U
U
Olsson
H
H
D000328:Adult; D001940:Breast / Q000033:anatomy & histology*; D001943:Breast Neoplasms / Q000517:prevention & control*; D003069:Coffee; D019388:Cytochrome P-450 CYP1A2 / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans
D003069:Coffee; C504573:CYP1A2 protein, human; D019388:Cytochrome P-450 CYP1A2