Targeting virulence traits: potential strategies to combat extraintestinal pathogenic E. coli infections.
Extraintestinal pathogenic Escherichia coli (ExPEC) are able to colonize, invade and induce disease in body niches outside the gastrointestinal tract. The emergence of (multi)resistant ExPEC variants calls for alternative antimicrobial strategies with a reduced pressure on selection of antibiotic resistances. We report on recent research efforts to target such virulence traits or to interfere with ExPEC colonization of extraintestinal niches in order to prevent or treat ExPEC infections and reduce the risk of further emergence of antibiotic resistances.
Dobrindt
Ulrich
U
University of Würzburg, Institute for Molecular Infection Biology, Röntgenring 11, 97070 Würzburg, Germany.
Hacker
Jörg
J
D000818:Animals; D000898:Antibiosis; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000187:drug effects*; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000382:microbiology* / Q000517:prevention & control; D029968:Escherichia coli Proteins / Q000037:antagonists & inhibitors*; D022361:Escherichia coli Vaccines / Q000276:immunology; D006801:Humans; D037521:Virulence Factors / Q000037:antagonists & inhibitors*
D029968:Escherichia coli Proteins; D022361:Escherichia coli Vaccines; D037521:Virulence Factors