title: Metabolic-flow relationships in primary breast cancer: feasibility of combined PET/dynamic contrast-enhanced CT.
abstract: OBJECTIVE
  To assess the feasibility and first experience of combined (18)F-FDG-PET)/dynamic contrast-enhanced (DCE) CT in evaluating breast cancer.
  
  
  METHODS
  Nine consecutive female patients (mean age 64.2 years, range 52-74 years) with primary breast carcinoma were prospectively recruited for combined (18)F-FDG PET/DCE-CT. Dynamic CT data were used to calculate a range of parameters of tumour vascularity, and tumour (18)F-FDG uptake (standardized uptake value, SUVmax) was used as a metabolic indicator.
  
  
  RESULTS
  One tumour did not enhance and was excluded. The mean tumour SUVmax was 7.7 (range 2.4-26.1). The mean values for tumour perfusion, perfusion normalized to cardiac output, standard perfusion value (SPV) and permeability were 41 ml/min per 100 g (19-59 ml/min per 100 g), 0.56%/100 g (0.33-1.09%/100 g), 3.6 (2.5-5.9) and 0.15/min (0.09-0.30/min), respectively. Linear regression analysis showed a positive correlation between tumour SUV and tumour perfusion normalized to cardiac output (r=0.55, p=0.045) and a marginal correlation between tumour SUV and tumour SPV (r=0.19, p=0.065). There were no significant correlations between tumour SUV and tumour perfusion (r=0.29, p=0.401) or permeability (r=0.03, p=0.682).
  
  
  CONCLUSIONS
  The first data from combined (18)F-FDG-PET/DCE-CT in breast cancer are reported. The technique was successful in eight of nine patients. Breast tumour metabolic and vascular parameters were consistent with previous data from (15)O-H(2)O-PET.
authors.affiliation: Institute of Nuclear Medicine, UCL, UCH, 235 Euston Rd, London NW1 2BU, UK. drashleygroves@hotmail.com
authors.forename: Ashley M
authors.initials: AM
authors.lastname: Groves
authors.forename: Gordon C
authors.initials: GC
authors.lastname: Wishart
authors.forename: Manu
authors.initials: M
authors.lastname: Shastry
authors.forename: Penelope
authors.initials: P
authors.lastname: Moyle
authors.forename: Sharon
authors.initials: S
authors.lastname: Iddles
authors.forename: Peter
authors.initials: P
authors.lastname: Britton
authors.forename: Mathew
authors.initials: M
authors.lastname: Gaskarth
authors.forename: Ruth M
authors.initials: RM
authors.lastname: Warren
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Ell
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Miles
mesh_terms: D000368:Aged; D001365:Axilla; D001943:Breast Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000378:metabolism; D003287:Contrast Media; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18