Cellular automaton model of cell response to targeted radiation.
It has been shown that the response of cells to low doses of radiation is not linear and cannot be accurately extrapolated from the high dose response. To investigate possible mechanisms involved in the behaviour of cells under very low doses of radiation, a cellular automaton (CA) model was created. The diffusion and consumption of glucose in the culture dish were computed in parallel to the growth of cells. A new model for calculating survival probability was introduced; the communication between targeted and non-targeted cells was also included. Early results on the response of non-confluent cells to targeted irradiation showed the capability of the model to take account for the non-linear response in the low-dose domain.
Richard
M
M
Surrey Ion Beam Centre, Advanced Technology Institute, University of Surrey, Guildford, GU2 7XH, UK.
Kirkby
K J
KJ
Webb
R P
RP
Kirkby
N F
NF
D001692:Biological Transport; D002450:Cell Communication; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002477:Cells / Q000528:radiation effects*; D002478:Cells, Cultured; D004058:Diffusion; D004307:Dose-Response Relationship, Radiation; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D014965:X-Rays
D005947:Glucose