title: Pancreatic stellate cells and pancreatic cancer cells: an unholy alliance.
abstract: Pancreatic cancer--a tumor displaying a particularly abundant stromal reaction--is notorious for its poor prognosis. Recent studies, via newly developed orthotopic models, provide compelling evidence of an important role for pancreatic stellate cells (PSC) in pancreatic cancer progression. Characterization of the mechanisms mediating PSC-cancer interactions will lead to the development of much needed alternative therapeutic approaches to improve disease outcome.
authors.affiliation: Pancreatic Research Group, South Western Sydney Clinical School and School of Medical Sciences/Pathology, The University of New South Wales and Sydney, Sydney, NSW, Australia.
authors.forename: Alain
authors.initials: A
authors.lastname: Vonlaufen
authors.forename: Phoebe A
authors.initials: PA
authors.lastname: Phillips
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Xu
authors.forename: David
authors.initials: D
authors.lastname: Goldstein
authors.forename: Romano C
authors.initials: RC
authors.lastname: Pirola
authors.forename: Jeremy S
authors.initials: JS
authors.lastname: Wilson
authors.forename: Minoti V
authors.initials: MV
authors.lastname: Apte
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D018450:Disease Progression; D006801:Humans; D008954:Models, Biological; D010179:Pancreas / Q000166:cytology* / Q000502:physiology; D010190:Pancreatic Neoplasms / Q000209:etiology / Q000473:pathology*; D017154:Stromal Cells / Q000502:physiology*