title: Lymphoproliferative disease with features of lymphoma in the central nervous system of a horse.
abstract: Lymphoma (malignant lymphoma, lymphosarcoma) is uncommon in horses in the United Kingdom. This report describes an unusual form of lymphoproliferative disease with features of lymphoma restricted to the central nervous system (CNS) and with no evidence of a primary lesion elsewhere. Immunohistochemical examination defined an overwhelming predominance of T lymphocytes with admixed B lymphocytes and activated macrophages. This case exemplifies the challenges associated with definitive diagnosis of lymphoproliferative disease of the equine CNS.
authors.affiliation: Veterinary Pathology Unit, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian, EH25 9RG Scotland, United Kingdom. l.r.morrison@ed.ac.uk
authors.forename: L R
authors.initials: LR
authors.lastname: Morrison
authors.forename: K
authors.initials: K
authors.lastname: Freel
authors.forename: I
authors.initials: I
authors.lastname: Henderson
authors.forename: C
authors.initials: C
authors.lastname: Hahn
authors.forename: S H
authors.initials: SH
authors.lastname: Smith
mesh_terms: D000818:Animals; D016543:Central Nervous System Neoplasms / Q000473:pathology* / Q000503:physiopathology / Q000662:veterinary*; D006734:Horse Diseases / Q000276:immunology / Q000473:pathology*; D006736:Horses; D007150:Immunohistochemistry; D008223:Lymphoma / Q000473:pathology / Q000503:physiopathology / Q000662:veterinary*; D008297:Male