title: Controversies in the management of tongue base cancer.
abstract: BACKGROUND
  Tongue base cancer is one of the most lethal head and neck cancers. There is considerable controversy in the management of this disease with wide variation of opinion within the literature.
  
  
  METHODS
  We discuss the presentation, diagnostic and therapeutic strategies which exist in the literature. Articles were reviewed from 1970 to 2007 within the Medline, Pubmed and Cochrane libraries.
  
  
  CONCLUSIONS
  Smokers with a history of persistent unilateral neck pain, even in the absence of clinical signs warrant MRI neck imaging. Tongue base cancer organ preservation therapeutic strategies, radiation and concomitant platinum based chemotherapy, currently optimise oncologic and quality of life outcomes.
authors.affiliation: The Department of Otolaryngology, Head and Neck Surgery, Mid Western Regional Hospital, Dooradoyle, Limerick, Ireland. joneill@rcsi.ie
authors.forename: J P
authors.initials: JP
authors.lastname: O'Neill
authors.forename: J P
authors.initials: JP
authors.lastname: Hughes
authors.forename: K P
authors.initials: KP
authors.lastname: Manning
authors.forename: J E
authors.initials: JE
authors.lastname: Fenton
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D034462:Dissent and Disputes; D005260:Female; D006801:Humans; D007494:Ireland / Q000453:epidemiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D014062:Tongue Neoplasms / Q000188:drug therapy* / Q000453:epidemiology / Q000532:radiotherapy / Q000601:surgery