Exposure assessment of French women and their newborn to brominated flame retardants: determination of tri- to deca- polybromodiphenylethers (PBDE) in maternal adipose tissue, serum, breast milk and cord serum.
In the frame of a French monitoring program, tri- to deca- polybromodiphenylethers (PBDE) have been measured in maternal and cord serum, adipose tissue, and breast milk samples, collected from 93 volunteer women during caesarean deliveries. The seven major tri- to heptaBDE (BDE-28, 47, 99, 100, 153, 154, and 183) were detected in adipose tissue and breast milk with cumulated median values of 2.59 and 2.51 ng g(-1) l w. Nine highly brominated octa- to decaBDE (BDE-196, 197, 201, 202, 203, 206, 207, 208 and 209) was performed in the same samples, with cumulated median values of 2.73 and 3.39 ng g(-1) l w in adipose tissue and breast milk, respectively. At this opposite, median levels of octa- to decaBDE in maternal and cord serum appeared significantly higher than the levels of tri- to heptaBDE in the same matrices, i.e. 8.85 and 12.34 versus 0.98 and 0.69 ng g(-1) l w, respectively.
Antignac
Jean-Philippe
JP
Laboratoire d'Etude des Résidus et Contaminants dans les Aliments, USC INRA 2013, Ecole Nationale Vétérinaire de Nantes, Route de Gachet, BP 50707, 44307 Nantes Cedex 3, France. antignac@vet-nantes.fr
Cariou
Ronan
R
Zalko
Daniel
D
Berrebi
Alain
A
Cravedi
Jean-Pierre
JP
Maume
Daniel
D
Marchand
Philippe
P
Monteau
Fabrice
F
Riu
Anne
A
Andre
François
F
Le Bizec
Bruno
B
D000273:Adipose Tissue / Q000737:chemistry*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005411:Flame Retardants / Q000032:analysis*; D055768:Halogenated Diphenyl Ethers / Q000032:analysis* / Q000097:blood / Q000737:chemistry; D006801:Humans; D007231:Infant, Newborn; D018811:Maternal Exposure; D008895:Milk, Human / Q000737:chemistry*; D008970:Molecular Weight; D012306:Risk; D013048:Specimen Handling
D005411:Flame Retardants; D055768:Halogenated Diphenyl Ethers