CASP8 D302H and meningioma risk: an analysis of five case-control series.
Caspase 8 (CASP8) is a key regulator of apoptosis or programmed cell death, and hence a defence against cancer. The CASP8 polymorphism D302H has recently been shown to influence the risk of breast cancer. We tested the hypothesis that the CASP8 polymorphism D302H may influence risk of meningioma through analysis of five independent series of case patients and controls (n=631 and 637, respectively). Carrier status for 302H was not associated with a statistically significantly increased risk (OR=1.16; 95% CI: 0.87-1.53; P=0.31) making it unlikely that this variant contributes to the inherited risk of meningioma.
Bethke
Lara
L
Section of Cancer Genetics, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.
Sullivan
Kate
K
Webb
Emily
E
Murray
Anne
A
Schoemaker
Minouk
M
Auvinen
Anssi
A
Kiuru
Anne
A
Salminen
Tiina
T
Johansen
Christoffer
C
Christensen
Helle Collatz
HC
Muir
Kenneth
K
McKinney
Patricia
P
Hepworth
Sarah
S
Dimitropoulou
Polyxeni
P
Lophatananon
Artitaya
A
Feychting
Maria
M
Lönn
Stefan
S
Ahlbom
Anders
A
Malmer
Beatrice
B
Henriksson
Roger
R
Swerdlow
Anthony
A
Houlston
Richard
R
D000328:Adult; D000368:Aged; D000483:Alleles; D017209:Apoptosis; D016022:Case-Control Studies; D053181:Caspase 8 / Q000235:genetics* / Q000502:physiology; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000235:genetics; D008579:Meningioma / Q000175:diagnosis / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012306:Risk
D053181:Caspase 8