[Seronin syndrome and cardiac arrest caused by high-dose moclobemide (case report)].
Serotonin syndrome is the syndrome resulting from brain tissue serotonin accumulation and accompanying by central nervous system dysfunction and circulatory collapse, which leads to a serious mortal danger to life. A female patient aged 31 years, diagnosed as having chronic psychosis in the history, was admitted to an intensive care unit in a critical state for having taking an increased moclobemide dose. The patient developed cardiac arrest and cardiopulmonary resuscitation (CPR) was initiated. A 15-minute CPR recovered sinus rhythm and pulse on the peripheral arteries of the limbs. When consciousness and respiration improved, the patient was weaned from resuscitation and extubated on the second day. On day 4, the patient was transferred from the intensive care unit to the department of psychiatry. The authors consider that patients with overdosage of antipsychotic agents at a risk for such serious complications, such as cardiac arrest, should be necessarily monitored in the intensive care unit.
Cekmen
N
N
Badalov
P
P
Erdemli
O
O
D000328:Adult; D005260:Female; D006323:Heart Arrest / Q000139:chemically induced* / Q000628:therapy; D006801:Humans; D020912:Moclobemide / Q000506:poisoning* / Q000627:therapeutic use; D008996:Monoamine Oxidase Inhibitors / Q000506:poisoning* / Q000627:therapeutic use; D011618:Psychotic Disorders / Q000188:drug therapy; D020230:Serotonin Syndrome / Q000139:chemically induced* / Q000628:therapy; D013406:Suicide, Attempted; D016896:Treatment Outcome
D008996:Monoamine Oxidase Inhibitors; D020912:Moclobemide