title: Synchronous occult cancers of the endometrium and fallopian tube in an MSH2 mutation carrier at time of prophylactic surgery.
abstract: BACKGROUND
  Women with Lynch syndrome have a 40 to 60% lifetime risk of endometrial cancer and a 10 to 12% lifetime risk of ovarian cancer and may consider prophylactic gynecological surgery as an option for risk reduction.
  
  
  METHODS
  We report a case of synchronous primary cancers of the endometrium and fallopian tube diagnosed at time of prophylactic surgery in an MSH2 mutation carrier.
  
  
  CONCLUSIONS
  Risk-reducing gynecological surgery in Lynch syndrome must include complete removal of the fallopian tubes in addition to the ovaries and endometrium, followed by careful pathological review. Prospective studies are needed to clarify the incidence of occult primary carcinoma of the fallopian tube among female MMR mutation carriers undergoing prophylactic surgery.
authors.affiliation: Department of Medical Genetics, McGill University Health Centre, Montreal, Quebec, Canada. laura.palma@muhc.mcgill.ca
authors.forename: Laura
authors.initials: L
authors.lastname: Palma
authors.forename: Victoria
authors.initials: V
authors.lastname: Marcus
authors.forename: Lucy
authors.initials: L
authors.lastname: Gilbert
authors.forename: George
authors.initials: G
authors.lastname: Chong
authors.forename: William D
authors.initials: WD
authors.lastname: Foulkes
mesh_terms: D016889:Endometrial Neoplasms / Q000235:genetics* / Q000601:surgery; D005185:Fallopian Tube Neoplasms / Q000235:genetics* / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D051718:MutS Homolog 2 Protein / Q000235:genetics*; D009154:Mutation; D009378:Neoplasms, Multiple Primary / Q000235:genetics* / Q000601:surgery; D010375:Pedigree
chemical_list: C497172:MSH2 protein, human; D051718:MutS Homolog 2 Protein