title: Orbital apex lesion due to Aspergillosis presenting in immunocompetent patients without apparent sinus disease.
abstract: We present two cases in which Aspergillus infection was identified at a late stage in the clinical evaluation as the cause for a painful, progressive and indolent orbital apex syndrome in the absence of any clinical or radiological sign of sinus involvement. Surgical investigation was undertaken with serious subsequent morbidity. Although treatment is often satisfactory, neurological outcome is without exception poor. A review of the literature has revealed that the risk of such investigations is high, and advice is provided to readers which may allow avoidance of such complications in the future.
authors.affiliation: Depts. of Neuro-ophthalmology, Moorfields Eye Hospital and Royal Free Hospital, London, UK.
authors.forename: L
authors.initials: L
authors.lastname: O'Toole
authors.forename: J A
authors.initials: JA
authors.lastname: Acheson
authors.forename: D
authors.initials: D
authors.lastname: Kidd
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D001228:Aspergillosis / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology / Q000628:therapy; D005260:Female; D006801:Humans; D007121:Immunocompetence; D008279:Magnetic Resonance Imaging; D009916:Orbital Diseases / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology / Q000628:therapy; D010254:Paranasal Sinus Diseases; D010784:Photomicrography
chemical_list: D000305:Adrenal Cortex Hormones