No detected hepatitis B virus-DNA in thalassemic patients infected by hepatitis C virus in Kerman province of Iran.
This research was aimed to investigate the prevalence and clinical impact of occult HBV infection in thalassemic patients with chronic HCV infection. In this cross-sectional study we have totally examined 60 patients suffering HBV and HCV infections by PCR and RT-PCR methods, respectively, in Kerman province of Iran. ELISA technique (RADIM, Italy) was used to detect anti-HBc, anti-HBs and HBsAg. The serum level of liver enzymes (SGOT, SGPT, DB, TB and ALK) were analyzed in the HCV infected patients (MAN, IRAN). Statistical analyses performed using t-test and Chi-square. We found that 27 cases (out of 60) were infected by HCV but HBV-DNA was not seen in HCV infected patients. Present findings also showed that none of samples were HBsAg positive but 9 (33%) (out of 27) HCV-RNA positive patients were anti-HBc positive and 11 (40.7%) were positive for anti-HBs. We found that SGOT, SGPT, DB, TB and ALK are above normal in 27 (100%), 19(70.3%), 12(44.5%), 15 (55.5%) and 15 (55.5%) RNA-HCV positive patients, respectively. The prevalence of hepatitis C infection is very high in thalassemic patients and based on other studies our results showed that the prevalence of HCV infection in Kerman is more than other provinces of Iran. In contrast with other studies HBV-DNA in these patients could not be detected, hence, it seems that occult HBV infection isn't frequent in Iranian thalassemic patients who suffering from chronic HCV infection.
Arababadi
Mohammad Kazemi
MK
Department of Microbiology, Hematology and Immunology, Faculty of Medicine, Rafsanjan University of Medical Science, Rafsanjan, Iran.
Hassanshahi
Gholamhossein
G
Yousefi
Hassan
H
Zarandi
Ebrahim Rezazadeh
ER
Moradi
Mohammad
M
Mahmoodi
Mahdi
M
D004279:DNA, Viral / Q000032:analysis* / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D006515:Hepatitis B virus / Q000235:genetics* / Q000302:isolation & purification; D006526:Hepatitis C / Q000150:complications* / Q000201:enzymology / Q000821:virology*; D006801:Humans; D007492:Iran; D008099:Liver / Q000201:enzymology; D008297:Male; D013789:Thalassemia / Q000150:complications* / Q000201:enzymology / Q000821:virology*; D013997:Time Factors
D004279:DNA, Viral