[Study on antidepressant components of sucrose ester from Polygala tenuifolia].
OBJECTIVE
To investigate the antidepressant components of Polygala tenuifolia.


METHODS
The chromatographic method was used to isolate and purify the chemical constituents, their structures were identified by spectral analysis, MTT method was applied to investigate their cytotoxic activities.


RESULTS
Nine compounds were isolated from the roots of P. tenuifolia. Their structures were identified as sibiricose A, (1), sibiricose A5 (2), tenuifoliside A (3) and 3', 6-disinapoyl sucrose (4), sibiricose A6 (5), 3, 4, 5-trimethoxycinnamate (6), polygalaxanthone III (7), tenuifolioses A (8), tenuifolioses H (9) and some compounds' activities to PC12 were observed.


CONCLUSIONS
Compound 1 was isolated from this plant for the first time. Compounds 2,3 could protect PC12 cells damage induced by P. tenuifolia.
Tu
Hai-Hua
HH
Dept of Clinical Pharmacology, General Hospital of PIM, Beijing 100853, China.
Liu
Ping
P
Mu
Liang
L
Liao
Hong-Bo
HB
Xie
Ting-Ting
TT
Ma
Li-Hua
LH
Liu
Yao-Ming
YM
D000818:Animals; D000928:Antidepressive Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004952:Esters / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D016716:PC12 Cells; D018517:Plant Roots / Q000737:chemistry; D031801:Polygala / Q000737:chemistry*; D051381:Rats; D013395:Sucrose / Q000737:chemistry*
D000928:Antidepressive Agents; D004952:Esters; D013395:Sucrose