title: Enantiopure 2-substituted glyceraldehyde derivatives by aza-Claisen rearrangement or C-alkylation of enamines.
abstract: 2-Alkyl derivatives of butane-2,3-diacetal (BDA) protected glyceraldehyde were stereoselectively prepared by aza-Claisen rearrangement of N-allyl-enammonium ions or C-alkylation of enamines. This allows rapid and convenient access to densely functionalized chiral building blocks.
authors.affiliation: Department of Chemistry, Lensfield Road, Cambridge, CB2 1EW, UK.
authors.forename: Katy L
authors.initials: KL
authors.lastname: Bridgwood
authors.forename: C Christoph
authors.initials: CC
authors.lastname: Tzschucke
authors.forename: Matthew
authors.initials: M
authors.lastname: O'Brien
authors.forename: Sven
authors.initials: S
authors.lastname: Wittrock
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Goodman
authors.forename: John E
authors.initials: JE
authors.lastname: Davies
authors.forename: Angus W J
authors.initials: AW
authors.lastname: Logan
authors.forename: Matthias R M
authors.initials: MR
authors.lastname: Hüttl
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley