title: Emotional regulation, or: how I learned to stop worrying and love the nucleus accumbens.
abstract: How does the brain control emotion? In this issue of Neuron, Wager et al. use a novel mediation analysis of neuroimaging data to show two independent pathways for the control of emotion by the prefrontal cortex: a path through the amygdala predicts a greater negative emotional response, and a path through the nucleus accumbens/ventral striatum predicts a greater positive response.
authors.affiliation: Department of Cognitive and Linguistic Sciences, Brown University, Providence, RI 02912, USA.
authors.forename: Sophie
authors.initials: S
authors.lastname: Lebrecht
authors.forename: David
authors.initials: D
authors.lastname: Badre
mesh_terms: D000223:Adaptation, Psychological / Q000502:physiology; D000679:Amygdala / Q000502:physiology*; D004644:Emotions / Q000502:physiology*; D006801:Humans; D009434:Neural Pathways / Q000502:physiology*; D017397:Prefrontal Cortex / Q000502:physiology*