Epithelial-immune cell interaction in dry eye.
Dry eye is a potent stimulus of both innate and adaptive immune systems. At the nexus of the dry eye inflammatory/immune response is the dynamic interplay between the ocular surface epithelia and the bone marrow-derived immune cells. On the one hand, ocular surface epithelial cells play a key initiating role in this inflammatory reaction. On the other hand, they are targets of cytokines produced by activated T cells that are recruited to the ocular surface in response to dry eye. This interaction between epithelial and immune cells in dry eye will be thoroughly reviewed.
Pflugfelder
Stephen C
SC
Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, TX 77030, USA. stevenp@bcm.tmc.edu
de Paiva
Cintia S
CS
Li
De-Quan
DQ
Stern
Michael E
ME
D000818:Animals; D000917:Antibody Formation; D001854:Bone Marrow Cells / Q000276:immunology; D016207:Cytokines / Q000378:metabolism; D015352:Dry Eye Syndromes / Q000150:complications / Q000276:immunology / Q000503:physiopathology* / Q000628:therapy; D004847:Epithelial Cells; D005123:Eye / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D007107:Immune System / Q000503:physiopathology; D007249:Inflammation / Q000209:etiology
D016207:Cytokines