Progenitor migration to the thymus and T cell lineage commitment.
T cells developing in the thymus are ultimately derived from bone marrow (BM) hematopoietic stem cells (HSCs). An understanding of the developmental steps between HSCs and T cells is important for gaining insight into cancers of the T lineage, improving T cell reconstitution after BM transplantation, and also to help ameliorate immunological defects in aging. In this article, we summarize our current understanding of the inter-related fields of early T cell development and thymic aging, and briefly discuss major unresolved questions in this field.
Sambandam
Arivazhagan
A
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA.
Bell
J Jeremiah
JJ
Schwarz
Benjamin A
BA
Zediak
Valerie P
VP
Chi
Anthony W
AW
Zlotoff
Daniel A
DA
Krishnamoorthy
Shanthi Lakshmi
SL
Burg
Jennifer M
JM
Bhandoola
Avinash
A
D000375:Aging / Q000276:immunology; D000818:Animals; D019070:Cell Lineage / Q000276:immunology; D002465:Cell Movement / Q000276:immunology*; D016207:Cytokines / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000276:immunology; D006801:Humans; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology; D013950:Thymus Gland / Q000166:cytology* / Q000276:immunology
D016207:Cytokines