title: Schizophrenia diagnosis and anterior hippocampal volume make separate contributions to sensory gating.
abstract: Impaired P50 gating is thought to reflect a core deficit in schizophrenia, but the relevant neural network is not well understood. The present study used EEG and MEG to assess sensory gating and volumetric MRI to measure hippocampal volume to investigate relationships between them in 22 normal controls and 22 patients with schizophrenia. In the schizophrenia group, anterior but not posterior hippocampal volume was smaller, and both the P50 and M50 gating ratios were larger (worse) than in controls. Independent of group, left-hemisphere M50 gating ratio correlated negatively with left anterior hippocampal volume, and right-hemisphere M50 gating ratio correlated negatively with right anterior hippocampal volume. Schizophrenia diagnosis predicted M50 gating independent of hippocampal volume. These results are consistent with the finding that hippocampus is a critical part of a fronto-temporal circuit involved in auditory gating.
authors.affiliation: Department of Psychiatry, University of New Mexico, Albuquerque, New Mexico 87131-0001, USA. rjthoma@salud.unm.edu
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Thoma
authors.forename: Faith M
authors.initials: FM
authors.lastname: Hanlon
authors.forename: Helen
authors.initials: H
authors.lastname: Petropoulos
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Miller
authors.forename: Sandra N
authors.initials: SN
authors.lastname: Moses
authors.forename: Ashley
authors.initials: A
authors.lastname: Smith
authors.forename: Lauren
authors.initials: L
authors.lastname: Parks
authors.forename: S Laura
authors.initials: SL
authors.lastname: Lundy
authors.forename: Natalie M
authors.initials: NM
authors.lastname: Sanchez
authors.forename: Aaron
authors.initials: A
authors.lastname: Jones
authors.forename: Mingxiong
authors.initials: M
authors.lastname: Huang
authors.forename: Michael P
authors.initials: MP
authors.lastname: Weisend
authors.forename: Jose M
authors.initials: JM
authors.lastname: Cañive
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001307:Auditory Perception / Q000502:physiology*; D003627:Data Interpretation, Statistical; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D008297:Male; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000188:drug therapy / Q000473:pathology*; D012565:Schizophrenic Psychology; D013017:Sound Localization / Q000502:physiology
chemical_list: D014150:Antipsychotic Agents