title: Synthesis and biological evaluation of 4beta-[(4-substituted)-1,2,3-triazol-1-yl]podophyllotoxins as potential anticancer agents.
abstract: A series of novel 4beta-[(4-substituted)-1,2,3-triazol-1-yl]podophyllotoxin derivatives were synthesized by employing Cu(I)-catalyzed click chemistry and evaluated for their anticancer activity against a panel of seven human cancer cell lines (HT-29, HCT-15, 502713, HOP-62, A-549, MCF-7, and SF-295). The compounds 9b, 9c, 9e, 9f, and 9h showed significant cytotoxic activities especially against HT-29, HCT-15, 502713 cell lines.
authors.affiliation: Department of Synthetic Chemistry, Indian Institute of Integrative Medicine, Jammu-Tawi 180001, India.
authors.forename: Pitta Bhaskar
authors.initials: PB
authors.lastname: Reddy
authors.forename: Satyam Kumar
authors.initials: SK
authors.lastname: Agrawal
authors.forename: Swaran
authors.initials: S
authors.lastname: Singh
authors.forename: Bilal A
authors.initials: BA
authors.lastname: Bhat
authors.forename: Ajit K
authors.initials: AK
authors.lastname: Saxena
authors.forename: Halmuthur M Sampath
authors.initials: HM
authors.lastname: Kumar
authors.forename: Gulam N
authors.initials: GN
authors.lastname: Qazi
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D011034:Podophyllotoxin / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D014230:Triazoles; D011034:Podophyllotoxin