Transformation of p53-positive papillary thyroid carcinoma to anaplastic carcinoma of the liver following postoperative radioactive iodine-131 therapy.
Multiple liver metastases were incidentally detected in the lobe of the liver of an 81-year-old woman following total thyroidectomy and ablative radioactive iodine administration for the treatment of papillary thyroid carcinoma. A biopsy specimen taken from the metastatic liver tumor was histologically diagnosed as anaplastic carcinoma. Immunohistochemical staining for p53 was positive in both the primary tumor and liver biopsy specimens. We considered this to have been caused by anaplastic transformation from papillary thyroid carcinoma during treatment. We report a rare case of multiple liver metastases from a papillary thyroid carcinoma, which we believe to be the result of anaplastic transformation during postoperative radioactive iodine-131 therapy.
Takeshita
Yumie
Y
Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science.
Takamura
Toshinari
T
Minato
Hiroshi
H
Misu
Hirofumi
H
Ando
Hitoshi
H
Yamashita
Tatsuya
T
Ikeda
Hiroko
H
Nakanuma
Yasuni
Y
Kaneko
Shuichi
S
D000368:Aged; D000369:Aged, 80 and over; D000708:Anaplasia; D002291:Carcinoma, Papillary / Q000378:metabolism* / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D016158:Genes, p53; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects*; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary*; D009154:Mutation; D011859:Radiography; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D013965:Thyroidectomy; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D007457:Iodine Radioisotopes; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53