title: [Case of severe rhabdomyolosis after protracted overdose of simvastatin].
abstract: The mechanisms of statin-induced muscle injury are not fully understood, and early recognition of statin myopathy is critical in order to prevent serious sequelae. The case of a 57-year-old woman who had accidentally taken a quadrupled dose of simvastatin over a period of 18 days is presented. The patient was admitted to hospital with severe rhabdomyolysis and treated with forced diuresis. Despite the rhabdomyolysis, the patient's kidney function was not affected, but reduced muscle function was observed which was still not fully regained 6 months later.
authors.affiliation: Storstrømmens Sygehus, Naestved, Medicinsk Afdeling. tinegreve@hoiby.dk
authors.forename: Tine
authors.initials: T
authors.lastname: Greve
mesh_terms: D000924:Anticholesteremic Agents / Q000506:poisoning*; D062787:Drug Overdose; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000506:poisoning*; D008875:Middle Aged; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000628:therapy; D019821:Simvastatin / Q000506:poisoning*; D013997:Time Factors
chemical_list: D000924:Anticholesteremic Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D019821:Simvastatin