title: Propofol infusion syndrome.
abstract: Propofol (Diprivan) is an intravenous sedative hypnotic that is used in the induction and maintenance of anesthesia and sedation. High-dose infusions have been associated with several serious adverse effects and, when combined, they are known as propofol infusion syndrome (PRIS). Although PRIS is rare, it is frequently fatal if not identified early. The purpose of this article is to raise practitioner awareness to this syndrome, with recommendations for early identification, prevention, and treatment of PRIS.
authors.affiliation: Department of Trauma Services, Henry Ford Hospital, Detroit, Michigan 48202, USA. crajda1@hfhs.org
authors.forename: Carol
authors.initials: C
authors.lastname: Rajda
authors.forename: Darlene
authors.initials: D
authors.lastname: Dereczyk
authors.forename: Patti
authors.initials: P
authors.lastname: Kunkel
mesh_terms: D000138:Acidosis / Q000139:chemically induced* / Q000175:diagnosis / Q000517:prevention & control; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced* / Q000175:diagnosis / Q000517:prevention & control; D003422:Critical Care; D016903:Drug Monitoring / Q000451:nursing; D042241:Early Diagnosis; D006801:Humans; D006949:Hyperlipidemias / Q000139:chemically induced; D015228:Hypertriglyceridemia / Q000139:chemically induced; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000009:adverse effects*; D007262:Infusions, Intravenous; D024802:Nurse's Role; D009730:Nursing Assessment; D010353:Patient Education as Topic; D017410:Practice Guidelines as Topic; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects*; D035583:Rare Diseases; D012206:Rhabdomyolysis / Q000139:chemically induced; D012307:Risk Factors; D012770:Shock, Cardiogenic / Q000139:chemically induced* / Q000175:diagnosis / Q000517:prevention & control; D013577:Syndrome
chemical_list: D018686:Anesthetics, Intravenous; D006993:Hypnotics and Sedatives; D015742:Propofol