Cytotoxic beta-dihydroagarofuran sesquiterpenoids from the fruits of Celastrus orbiculatus.
Assay-guided fractionation led to the isolation of nine beta-dihydroagarofuran sesquiterpenoids from the fruits of Celastrus orbiculatus. All isolated beta-dihydroagarofuran sesquiterpenoids were tested for their cytotoxic activity against human melanoma A375-S2 and human cervical carcinoma Hela cell lines. Among them, compounds 1-5 and 7 showed cytotoxic activity. Compound 3 exhibited promising cytotoxicity against both human melanoma A375-S2 and human cervical carcinoma Hela cell lines. The structure-activity relationship was discussed briefly.
Xu
Jing
J
Department of Pharmaceutical Sciences, Nankai University, Tianjin 300071, P.R. China.
Guo
Yuan-Qiang
YQ
Li
Xian
X
Wei
Kun
K
Zhao
Xiaojun
X
Zhang
Shuzhong
S
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D012717:Sesquiterpenes / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes; C079978:dihydroagarofuran