title: Catalytic chain-breaking pyridinol antioxidants.
abstract: When assayed for their capacity to inhibit azo-initiated peroxidation of linoleic acid in a water/chlorobenzene two-phase system, tellurium-containing 3-pyridinols were readily regenerable by N-acetylcysteine contained in the aqueous phase. The best inhibitors quenched peroxyl radicals more efficiently than alpha-tocopherol, and the duration of inhibition was limited only by the availability of the thiol reducing agent. The compounds were also found to catalyze reduction of hydrogen peroxide in the presence of thiol reducing agent.
authors.affiliation: Department of Biochemistry and Organic Chemistry, Uppsala University, Box 576, SE-75123 Uppsala, Sweden.
authors.forename: Sangit
authors.initials: S
authors.lastname: Kumar
authors.forename: Henrik
authors.initials: H
authors.lastname: Johansson
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kanda
authors.forename: Lars
authors.initials: L
authors.lastname: Engman
authors.forename: Thomas
authors.initials: T
authors.lastname: Müller
authors.forename: Mats
authors.initials: M
authors.lastname: Jonsson
authors.forename: Gian Franco
authors.initials: GF
authors.lastname: Pedulli
authors.forename: Silvia
authors.initials: S
authors.lastname: Petrucci
authors.forename: Luca
authors.initials: L
authors.lastname: Valgimigli