title: Evaluation of a proposed therapeutic protocol in 12 dogs with tentative degenerative myelopathy.
abstract: The objective of this work was to evaluate the long-term efficacy of a proposed therapeutic protocol in 12 dogs with a tentative diagnosis of degenerative myelopathy, followed-up for a 6-month period. Twelve dogs fulfilling the antemortem inclusion criteria (breed, age, adequate vaccination, history of progressive posterior ataxia and/or paraparesis, no radiographic and myelographic abnormalities in the spinal cord and vertebral column) were allocated. All these dogs presented signs of thoracolumbar syndrome (T3-L3), scored as grade I (mild to moderate ataxia and paraparesis) in 10 and grade II (severe ataxia and ambulatory paraparesis) in 2 cases. Treatment included the use of epsilon-aminocaproic acid and N-acetylcysteine, supplemented with vitamins B, C and E. Prednisolone was given for the first two weeks and upon worsening of neurological signs. Daily exercise, performed as walking or swimming, was strongly recommended. Clinicopathological evaluation was normal in all 12 dogs, and survey radiographs and myelograms did not show spinal cord compression. Magnetic resonance imaging (MRI), performed only in 4 dogs, did not disclose compressive disorders or intramedullary lesions. Neurological signs were progressively worsening in all 12 animals, eventually resulting in severe paraparesis (grade III) or paraplegia (grade IV). The applied medications do not appear to be an attractive alternative to conservative management (physiotherapy) or euthanasia in canine degenerative myelopathy, irrespective of its chronicity.
authors.affiliation: Diagnostic Laboratory, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, 546 27 Thessaloniki, Stavrou Voutyra st. 11, Greece. poliz@vet.auth.gr
authors.forename: Zoe S
authors.initials: ZS
authors.lastname: Polizopoulou
authors.forename: Alexander F
authors.initials: AF
authors.lastname: Koutinas
authors.forename: Michael N
authors.initials: MN
authors.lastname: Patsikas
authors.forename: Nektarios
authors.initials: N
authors.lastname: Soubasis
mesh_terms: D000818:Animals; D018450:Disease Progression; D004283:Dog Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D004285:Dogs; D005260:Female; D020022:Genetic Predisposition to Disease; D007794:Lameness, Animal / Q000209:etiology; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000662:veterinary; D008297:Male; D009192:Myelography / Q000662:veterinary; D019636:Neurodegenerative Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D010805:Physical Conditioning, Animal / Q000502:physiology*; D012720:Severity of Illness Index; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging / Q000473:pathology; D017211:Treatment Failure