title: Microwave-assisted parallel synthesis of fused heterocycles in a novel parallel multimode reactor.
abstract: New rotor types using disposable glass vials for small-scale parallel synthesis in multimode microwave reactors are introduced. One rotor comprises 16 groups of four vials, whereas the second uses four silicon carbide plates with a 6 x 4 matrix to process the vials. Both rotors achieve utmost temperature homogeneity upon microwave irradiation and can be used for microwave-mediated reactions at temperatures of up to 200 degrees C and pressures of 20 bar. The generation of three different heterocycle libraries furnishing thiophenes, oxindoles, and benzimidazoles using the new rotor types is described.
authors.affiliation: Boehringer Ingelheim Austria GmbH, Dr. Boehringer Gasse 5-11, A-1121 Vienna, Austria.
authors.forename: Matthias
authors.initials: M
authors.lastname: Treu
authors.forename: Thomas
authors.initials: T
authors.lastname: Karner
authors.forename: Roland
authors.initials: R
authors.lastname: Kousek
authors.forename: Helmut
authors.initials: H
authors.lastname: Berger
authors.forename: Moriz
authors.initials: M
authors.lastname: Mayer
authors.forename: Darryl B
authors.initials: DB
authors.lastname: McConnell
authors.forename: Alexander
authors.initials: A
authors.lastname: Stadler
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000295:instrumentation*; D004867:Equipment Design; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D008872:Microwaves; D054852:Small Molecule Libraries / Q000138:chemical synthesis; D013696:Temperature
chemical_list: D006571:Heterocyclic Compounds; D054852:Small Molecule Libraries