title: Little impact of donor/recipient major mismatch for neutrophil-specific antigen NA2 on neutrophil recovery after allogeneic SCT.
abstract: The Fcgamma receptor IIIb (FcgammaRIIIb), a receptor for the Fcgamma region of IgG, is specifically expressed on neutrophils. It has two allelic polymorphisms, NA1 and NA2, which are highly immunogenic and act as targets in alloimmune or autoimmune neutropenia. Thus, neutrophil antigens (NA) compatibility of donor/recipient pairs might be expected to affect the engraftment of neutrophils after allogeneic SCT (allo-SCT). Here, the impact of NA compatibility of 17 patients and their donors undergoing allo-SCT with a myeloablative regimen was determined. Leukocyte depletion filters were used for all transfusions before and post-SCT; most patients received G-CSF after transplant. Major mismatches for NA1 and NA2 were present in 1 and 7 patient/donor pairs, respectively. These eight patients receiving NA major-mismatched allo-SCT were compared with nine patients who received NA compatible allo-SCT. Engraftment of neutrophils and the incidence of post-engraftment neutropenia were found to be identical in the two groups. Despite the limitations in statistical power because of the small number of patients analyzed, these observations suggest that the major mismatching for NA2 antigen has little impact on the engraftment of neutrophils after myeloablative allo-SCT, at least in patients transfused using leukocyte depletion filters and receiving G-CSF after transplantation.
authors.affiliation: Department of Paediatrics, School of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan. tinukai@yamanashi.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Inukai
authors.forename: K
authors.initials: K
authors.lastname: Goi
authors.forename: T
authors.initials: T
authors.lastname: Tezuka
authors.forename: K
authors.initials: K
authors.lastname: Uno
authors.forename: A
authors.initials: A
authors.lastname: Nemoto
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: H
authors.initials: H
authors.lastname: Sato
authors.forename: K
authors.initials: K
authors.lastname: Akahane
authors.forename: K
authors.initials: K
authors.lastname: Hirose
authors.forename: H
authors.initials: H
authors.lastname: Honna
authors.forename: I
authors.initials: I
authors.lastname: Kuroda
authors.forename: K
authors.initials: K
authors.lastname: Kagami
authors.forename: K
authors.initials: K
authors.lastname: Nakamoto
authors.forename: K
authors.initials: K
authors.lastname: Taniguchi
authors.forename: S
authors.initials: S
authors.lastname: Nakazawa
authors.forename: K
authors.initials: K
authors.lastname: Sugita
mesh_terms: D000293:Adolescent; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006085:Graft Survival / Q000276:immunology; D016179:Granulocyte Colony-Stimulating Factor / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D007223:Infant; D007519:Isoantigens / Q000276:immunology*; D008297:Male; D051379:Mice; D009503:Neutropenia / Q000276:immunology; D009504:Neutrophils / Q000276:immunology*; D033581:Stem Cell Transplantation / Q000379:methods*; D014019:Tissue Donors; D019172:Transplantation Conditioning
chemical_list: D000911:Antibodies, Monoclonal; D007519:Isoantigens; C072753:neutrophil-specific antigen NA2; D016179:Granulocyte Colony-Stimulating Factor