Randomised trial comparing ocular lubricants and polyacrylamide hydrogel dressings in the prevention of exposure keratopathy in the critically ill.
OBJECTIVE
To compare the cost and effectiveness of the two most popular forms of eye care in intensive care, ocular lubricant (Lacrilube) and polyacrylamide hydrogel dressings (Geliperm); for the prevention of exposure keratopathy in the critically ill.


METHODS
A prospective randomised contralateral eye study was conducted at the Intensive Care Unit (ICU), Royal London Hospital, London, UK. Eighty eyes of 40 patients were recruited. Each patient received both Lacrilube and Geliperm allocated at random to different sides. A daily ophthalmology ward round was conducted. The outcome measures included the greatest palpebral aperture length, conjunctival oedema, and any exposure keratopathy.


RESULTS
There was no statistically significant difference in the maximum corneal exposure score between the eyes treated with Lacrilube and Geliperm (P = 0.38). No significant difference in degree of chemosis or palpebral aperture was identified.


CONCLUSIONS
Our data suggest that Geliperm is as effective as Lacrilube in the prevention of exposure keratopathy in the critically ill. We also note that nursing staff must be fully trained in its application for eye care.
Ezra
Daniel G
DG
Moorfields Eye Hospital, London, UK. d.ezra@ucl.ac.uk
Chan
Michelle P Y
MP
Solebo
Lola
L
Malik
Aeesha P
AP
Crane
Elizabeth
E
Coombes
Andrew
A
Healy
Marie
M
D000178:Acrylamides / Q000627:therapeutic use*; D000180:Acrylic Resins / Q000627:therapeutic use*; D000362:Agar / Q000627:therapeutic use*; D003316:Corneal Diseases / Q000188:drug therapy* / Q000453:epidemiology*; D016638:Critical Illness / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009779:Occlusive Dressings; D009883:Ophthalmic Solutions / Q000627:therapeutic use*; D011446:Prospective Studies
D000178:Acrylamides; D000180:Acrylic Resins; C044284:Geliperm; D009883:Ophthalmic Solutions; C016680:polyacrylamide gels; D000362:Agar