title: Acute retinal pigment epithelial detachment secondary to pamidronate administration.
abstract: Bisphosphonates are associated with an important number of inflammatory ocular side-effects including but not limited to conjunctivitis, episcleritis, scleritis, uveitis, and optic neuritis. The intravenous bisphosphonates appear to be linked with more severe ocular inflammation than the orally administered ones. These eye complications tend to resolve with the bisphosphonate discontinuation and can re-occur with its re-challenge. We present here the first case of an acute retinal pigment epithelial detachment associated with pamidronate infusion in a 59-year-old patient with metastatic prostate cancer.
authors.affiliation: c_dasanu@yahoo.com
authors.forename: Constantin A
authors.initials: CA
authors.lastname: Dasanu
authors.forename: Doru T
authors.initials: DT
authors.lastname: Alexandrescu
mesh_terms: D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000556:secondary; D004164:Diphosphonates / Q000009:adverse effects*; D005451:Fluorescein Angiography; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D000077268:Pamidronate; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000473:pathology; D011859:Radiography; D012163:Retinal Detachment / Q000139:chemically induced* / Q000000981:diagnostic imaging
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D000077268:Pamidronate