[Optimization for formulation matrix proportion of xiangyu cataplasm by uniform design].
OBJECTIVE
To optimize the matrix formulation of cataplasm used to cure infantile diarrhea.


METHODS
The optimum proportion of matrix for the preparation technology process of cataplasm was selected by uniform design and SPSS regression analysis. A check-up for adhibition , peeling strength, nonflowing, content of cream was founded.


RESULTS
The best matrix's prescription gelatin: CMC-Na: PANA: kaolin: aluminum trichloride: citric acid: PVP K-30: PEG400: trimethylene glycol: tween-80 was 0.25 : 0.1 : 0.2 : 1.5 : 0.4 : 0.6 : 0.8 : 2 : 1 : 0.5.


CONCLUSIONS
The preparation technique of cataplasm is feasible, and its quality is steerable, it is a safe and effective transdermal-drug delivery system.
Xu
Ke
K
Wuhan University of Technology, Wuhan 430070, China. xuke_coco@163.com
Xu
Pei-Hu
PH
Zhang
Xue-Qiong
XQ
Gao
Yuan
Y
Zhang
Liang
L
D000268:Adhesiveness; D000704:Analysis of Variance; D001672:Biocompatible Materials / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D004338:Drug Combinations; D016503:Drug Delivery Systems; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000378:metabolism; D005780:Gelatin / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D012869:Skin Absorption; D013678:Technology, Pharmaceutical / Q000379:methods
D001672:Biocompatible Materials; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005780:Gelatin