[The anxyolytic effect of mild hypobaric hypoxia in a model of post-traumatic stress disorder in rats].
The impact of mild hypobaric hypoxia on the development of anxiety-like state in rats in experimentally simulated human post-traumatic stress disorder was studied. Three-trial exposure to mild hypobaric hypoxia (360 mm Hg for 2 hours daily, for 3 days) in preconditioning or post-conditioning mode performed, respectively, before or after exposure to severe traumatic stress in the "stress-restress" model produced a significant anxiolytic effect on the rat open-field and plus-maze behavior. Anxiolytic effect of modem antidepressant Paxil (20 mg/kg daily, for 3 days) was weaker. This drug produced side-effects on particular behavioral characteristics in the open field. The conclusion was made on the efficacy of mild hypobaric hypoxia and the possibility of its implementation as a medication-free tool for prophylaxis and correction of post-traumatic stress disorder.
Rybnikova
E A
EA
Mironova
V I
VI
Tiul'kova
E I
EI
Samoĭlov
M O
MO
D000532:Altitude Sickness / Q000503:physiopathology / Q000628:therapy*; D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D000860:Hypoxia; D008297:Male; D017374:Paroxetine / Q000009:adverse effects / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013313:Stress Disorders, Post-Traumatic / Q000503:physiopathology / Q000628:therapy*
D018687:Antidepressive Agents, Second-Generation; D017374:Paroxetine