Suppression of the aging-associated decline in physical performance by a combination of resveratrol intake and habitual exercise in senescence-accelerated mice.
The decline in physical performance with increasing age is a crucial problem in our aging society. We examined the effects of resveratrol, a natural polyphenolic compound present in grapes, in combination with habitual exercise on the aging-associated decline in physical performance in senescence-accelerated prone mice (SAMP1). The endurance capacity of SAMP1 mice undergoing an exercise regimen (SAMP1-Ex) decreased over 12 weeks whereas that of SAMP1 mice fed 0.2% (w/w) resveratrol along with exercise (SAMP1-ExRes) remained significantly higher. In the SAMP1-ExRes group, there was a significant increase in oxygen consumption and skeletal muscle mRNA levels of mitochondrial function-related enzymes. These results suggest that the intake of resveratrol, together with habitual exercise, is beneficial for suppressing the aging-related decline in physical performance and that these effects are attributable, at least in part, to improved mitochondrial function in skeletal muscle.
Murase
Takatoshi
T
Biological Science Laboratories, Kao Corporation, Haga-gun, Tochigi, Japan. murase.takatoshi@kao.co.jp
Haramizu
Satoshi
S
Ota
Noriyasu
N
Hase
Tadashi
T
D000367:Age Factors; D000375:Aging / Q000235:genetics / Q000378:metabolism; D000818:Animals; D015415:Biomarkers / Q000097:blood; D004734:Energy Metabolism / Q000187:drug effects; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D008931:Mitochondria, Muscle / Q000187:drug effects / Q000201:enzymology; D024101:Mitochondrial Proteins / Q000235:genetics; D053580:Muscle Strength / Q000187:drug effects; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000201:enzymology; D010101:Oxygen Consumption / Q000187:drug effects; D010807:Physical Endurance / Q000187:drug effects*; D005082:Physical Exertion; D012333:RNA, Messenger / Q000378:metabolism; D000077185:Resveratrol; D012420:Running; D013267:Stilbenes / Q000494:pharmacology*; D013997:Time Factors
D015415:Biomarkers; D024101:Mitochondrial Proteins; D012333:RNA, Messenger; D013267:Stilbenes; D000077185:Resveratrol