title: Blood ghrelin, resistin, and adiponectin concentrations during the normal menstrual cycle.
abstract: OBJECTIVE
  To investigate changes of ghrelin, resistin, and adiponectin levels in the circulation during the normal menstrual cycle.
  
  
  METHODS
  Longitudinal study.
  
  
  METHODS
  The study was conducted at a university hospital.
  
  
  METHODS
  Eight healthy normally cycling women.
  
  
  METHODS
  The women were observed during a whole menstrual cycle. Daily blood samples were taken every morning, after overnight fasting, from day 2 of the cycle until the next menstrual period.
  
  
  METHODS
  Plasma acylated and unacylated ghrelin and serum resistin, adiponectin, FSH, LH, E(2), and P levels were measured in all blood samples.
  
  
  RESULTS
  In all women serum FSH, LH, E(2), and P levels, normalized to the midcycle peak LH value, showed the typical changes of the normal menstrual cycle. Acylated and unacylated ghrelin, resistin, and adiponectin levels did not change significantly during the whole menstrual cycle.
  
  
  CONCLUSIONS
  The present study shows for the first time that plasma ghrelin and serum resistin levels do not change significantly during the normal menstrual cycle. It is also confirmed that serum adiponectin levels remain stable throughout the cycle. It is suggested that ovarian steroid dynamics during the cycle have no effect on the secretion of these substances.
authors.affiliation: Department of Obstetrics and Gynecology, University of Thessalia, Larissa, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Dafopoulos
authors.affiliation: Department of Obstetrics and Gynecology, University of Thessalia, Larissa, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Sourlas
authors.affiliation: Department of Obstetrics and Gynecology, University of Thessalia, Larissa, Greece.
authors.forename: Athanasios
authors.initials: A
authors.lastname: Kallitsaris
authors.affiliation: Department of Microbiology, University of Thessalia, Larissa, Greece.
authors.forename: Spyros
authors.initials: S
authors.lastname: Pournaras
authors.affiliation: Department of Obstetrics and Gynecology, University of Thessalia, Larissa, Greece. Electronic address: messinis@med.uth.gr.
authors.forename: Ioannis E
authors.initials: IE
authors.lastname: Messinis
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D008137:Longitudinal Studies; D007986:Luteinizing Hormone / Q000097:blood; D008597:Menstrual Cycle / Q000097:blood*; D009994:Osmolar Concentration; D011374:Progesterone / Q000097:blood; D052243:Resistin / Q000097:blood*; D055815:Young Adult
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D054439:Ghrelin; C499624:RETN protein, human; D052243:Resistin; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone