Deconstructing meiosis one kinase at a time: polo pushes past pachytene.
The transition from pachytene to Meiosis I is a key regulatory point in yeast meiosis. This transition requires Ndt80, a transcription factor that commits cells to complete meiosis by expression of a diverse set of genes. In this issue of Genes & Development, Sourirajan and Lichten (2627-2632) report that CDC5, an NDT80-regulated gene encoding yeast polo-like kinase, is sufficient for Holliday junction resolution and exit from pachytene. Determining the meiotic targets of Cdc5 therefore provides a new approach for identifying a eukaryotic Holliday resolvase.
Hollingsworth
Nancy M
NM
Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794, USA. nhollin@ms.cc.sunnysb.edu
D018797:Cell Cycle Proteins / Q000235:genetics / Q000502:physiology; D015825:Chromosomes, Fungal / Q000235:genetics / Q000648:ultrastructure; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology; D005800:Genes, Fungal; D008540:Meiosis / Q000235:genetics* / Q000502:physiology*; D008954:Models, Biological; D049471:Pachytene Stage / Q000235:genetics* / Q000502:physiology*; D011494:Protein Kinases / Q000235:genetics* / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000235:genetics / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology
D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; C097071:NDT80 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases; C081927:CDC5 protein, S cerevisiae