title: Mitogen-activated protein kinases in hemostasis and  thrombosis.
abstract: The mitogen-activated protein (MAP) kinases ERK2, p38 and JNK1 are present in platelets and are activated by various stimuli, such as thrombin, collagen, von Willebrand factor (VWF) and ADP. Until recently, MAP kinases were only studied in the conventional model of agonist-induced platelet aggregation mediated by fibrinogen and integrin alphaIIbbeta3. However, this approach is likely to be too limited for a physiological understanding of platelet MAP kinases and their signaling pathways. Recent studies with varying blood-flow conditions and animal models of thrombosis have provided deeper insight into the role of MAP kinases in thrombus formation and the dependence of these kinases on shear conditions. This review summarizes and discusses the physiological functions of these kinases in hemostasis and thrombosis as revealed by various technical approaches.
authors.affiliation: Centre de Recherche Cardiovasculaire INSERM Lariboisiére U689, Hôpital Lariboisiére, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Adam
authors.forename: A
authors.initials: A
authors.lastname: Kauskot
authors.forename: J-P
authors.initials: JP
authors.lastname: Rosa
authors.forename: M
authors.initials: M
authors.lastname: Bryckaert
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000201:enzymology; D006487:Hemostasis; D006801:Humans; D020928:Mitogen-Activated Protein Kinases / Q000502:physiology*; D013927:Thrombosis
chemical_list: D020928:Mitogen-Activated Protein Kinases