Acute erythema and edematous skin reaction and ectropion following docetaxel in a patient with non-small cell lung cancer.
Docetaxel can cause skin reactions such as hypersensitivity, edema, and erythrodysesthesia syndrome as well as side effects involving the skin, including alopecia, nail onycholysis, nail pigmentation, photosensitivity, scleroderma, and paresthesia. In this case report, a patient was admitted to the hospital with widespread erythematous and edematous eruption in the head, neck, trunk, and lower and upper extremities, erythema around the eyes, and drooping of the lower eyelids that developed about 2 hours after receiving chemotherapy consisting of docetaxel. Use of the Naranjo Adverse Drug Reaction Probability Scale--a method for estimating the probability of adverse drug reactions--indicated a probable relationship between the skin reaction and docetaxel therapy in this patient. Docetaxel-associated skin reactions that are so extensive and severe as to lead to eye madarosis and ectropion are reported rarely in the literature.
Kaya
Ali Osman
AO
Department of Medical Oncology, Gazi University Faculty of Medicine, Ankara, Turkey.
Buyukberber
Suleyman
S
Coskun
Ugur
U
Yildiz
Ramazan
R
Ozturk
Banu
B
Yaman
Emel
E
Adisen
Esra
E
Gureli
Mustafa
M
Benekli
Mustafa
M
D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D016190:Carboplatin / Q000009:adverse effects / Q000627:therapeutic use; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy; D000077143:Docetaxel; D003875:Drug Eruptions / Q000473:pathology*; D004483:Ectropion / Q000139:chemically induced*; D004487:Edema / Q000139:chemically induced*; D004890:Erythema / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged; D043823:Taxoids / Q000009:adverse effects* / Q000627:therapeutic use
D000970:Antineoplastic Agents; D043823:Taxoids; D000077143:Docetaxel; D016190:Carboplatin