The effect of Anethum graveolens L. (dill) on corticosteroid induced diabetes mellitus: involvement of thyroid hormones.
An investigation was made to evaluate the role of Anethum graveolens L. (dill) leaf extract in the regulation of corticosteroid-induced type 2 diabetes mellitus in female rats. In dexamethasone-treated animals (1 mg/kg for 22 days) an increase in serum concentration of insulin and glucose and in hepatic lipid peroxidation (LPO) was observed. However, there was a decrease in serum concentration of thyroid hormones and in the endogenous antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH) in liver. In animals treated with an equivalent amount of dexamethasone for a similar period (22 days) when received the leaf extract (100 mg/kg b.wt/d.) for last 15 days a decrease in the concentration of both serum glucose and insulin was observed, indicating the potential of the plant extract in the regulation of corticosteroid-induced diabetes. Dexamethasone-induced alterations in the levels of thyroid hormones as well as in hepatic LPO, SOD, CAT and GSH were also reversed by the plant extract.
Panda
Sunanda
S
School of Life Sciences, Devi Ahilya University, Indore, India. spanda4@rediffmail.com
D000704:Analysis of Variance; D028524:Anethum graveolens / Q000737:chemistry*; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D002374:Catalase / Q000097:blood / Q000187:drug effects; D003907:Dexamethasone; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D005260:Female; D005978:Glutathione / Q000097:blood / Q000187:drug effects; D007328:Insulin / Q000097:blood; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000097:blood / Q000187:drug effects; D013963:Thyroid Hormones / Q000097:blood / Q000378:metabolism*
D001786:Blood Glucose; D007328:Insulin; D010936:Plant Extracts; D013963:Thyroid Hormones; D003907:Dexamethasone; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione