title: Metformine for psychosis associated with the menstrual cycle in a patient with polycystic ovary syndrome.
abstract: There are several reports of periodic psychotic disorders that appear in connection with the various phases of the menstrual cycle. Although the pathogenesis of menstrual psychosis has not been systematically investigated, it appears that it might be linked to an estrogen cascade that follows a period of sustained high estrogen levels, as in the case in anovulatory cycles. We present a case of psychosis associated with the menstrual cycle in a patient with polycystic ovary syndrome, a disorder typically characterized by anovulatory cycles, in whom the restoration of normal menstruation with use of metformine led to significant improvement of psychotic symptoms.
authors.affiliation: 1st Psychiatric Department, Aristotle University of Thessaloniki, Thessaloniki, Greece, chrandre@auth.gr
authors.forename: Christina
authors.initials: C
authors.lastname: Andreou
authors.forename: Markos
authors.initials: M
authors.lastname: Syngelakis
authors.forename: Athanasios
authors.initials: A
authors.lastname: Karavatos
mesh_terms: D000374:Aggression / Q000187:drug effects; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D008598:Menstruation / Q000523:psychology; D008687:Metformin / Q000008:administration & dosage*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000188:drug therapy* / Q000523:psychology*; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000523:psychology; D011644:Puerperal Disorders / Q000188:drug therapy* / Q000523:psychology; D055815:Young Adult
chemical_list: D007004:Hypoglycemic Agents; D008687:Metformin