title: Does AMP-activated protein kinase negatively mediate aged fast-twitch skeletal muscle mass?
abstract: The activity of 5'-adenosine monophosphate (AMP)-activated protein kinase (AMPK), a negative regulator of cell size, is up-regulated with age in resting and overloaded fast-twitch skeletal muscle but not slow-twitch muscle. Here, we provide evidence to support the hypothesis that elevated AMPK activity plays a potentially important integrative role in the age-related atrophy and diminished capacity for growth specific to fast-twitch skeletal muscle.
authors.affiliation: Human Performance Laboratory, 363 Ward Sports Medicine Building, East Carolina University, Greenville, NC 27858, USA. gordonsc@ecu.edu
authors.forename: Scott E
authors.initials: SE
authors.lastname: Gordon
authors.forename: Jordan A
authors.initials: JA
authors.lastname: Lake
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Westerkamp
authors.forename: David M
authors.initials: DM
authors.lastname: Thomson
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D000375:Aging; D049108:Cell Enlargement; D006801:Humans; D018656:Muscle Fibers, Fast-Twitch / Q000378:metabolism* / Q000502:physiology; D018482:Muscle, Skeletal / Q000502:physiology*; D009133:Muscular Atrophy / Q000378:metabolism / Q000503:physiopathology
chemical_list: D055372:AMP-Activated Protein Kinases