Structural biology by NMR: structure, dynamics, and interactions.
The function of bio-macromolecules is determined by both their 3D structure and conformational dynamics. These molecules are inherently flexible systems displaying a broad range of dynamics on time-scales from picoseconds to seconds. Nuclear Magnetic Resonance (NMR) spectroscopy has emerged as the method of choice for studying both protein structure and dynamics in solution. Typically, NMR experiments are sensitive both to structural features and to dynamics, and hence the measured data contain information on both. Despite major progress in both experimental approaches and computational methods, obtaining a consistent view of structure and dynamics from experimental NMR data remains a challenge. Molecular dynamics simulations have emerged as an indispensable tool in the analysis of NMR data.
Markwick
Phineus R L
PR
Département de Biologie Structurale et Chimie, Institut Pasteur, Unité de Bio-Informatique Structurale, CNRS URA 2185, Paris, France.
Malliavin
Thérèse
T
Nilges
Michael
M
D019295:Computational Biology / Q000379:methods*; D003627:Data Interpretation, Statistical; D046911:Macromolecular Substances; D008956:Models, Chemical; D008958:Models, Molecular; D008967:Molecular Biology / Q000706:statistics & numerical data; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011506:Proteins / Q000737:chemistry; D013816:Thermodynamics
D046911:Macromolecular Substances; D011506:Proteins