Dishevelled links basal body docking and orientation in ciliated epithelial cells.
Some epithelia contain cells with multiple motile cilia that beat in a concerted manner. New tools and experimental systems have facilitated molecular studies of cilium biogenesis and the coordinated planar polarization of cilia that leads to their concerted motility. A recent elegant study using embryonic frog epidermis demonstrates that Dishevelled, a key regulator of both the Wnt-beta-catenin and planar cell polarity pathways, controls both the docking and planar polarization of ciliary basal bodies.
Vladar
Eszter K
EK
Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305-5324, USA.
Axelrod
Jeffrey D
JD
D000199:Actins / Q000378:metabolism; D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D016764:Cell Polarity / Q000502:physiology; D002923:Cilia / Q000502:physiology*; D000072261:Dishevelled Proteins; D004625:Embryo, Nonmammalian / Q000378:metabolism; D004847:Epithelial Cells / Q000166:cytology / Q000502:physiology*; D010750:Phosphoproteins / Q000378:metabolism*; D012234:Rho Factor / Q000378:metabolism; D051153:Wnt Proteins / Q000378:metabolism*; D029867:Xenopus Proteins / Q000378:metabolism*; D014982:Xenopus laevis / Q000378:metabolism; D051176:beta Catenin / Q000378:metabolism*
D000199:Actins; D048868:Adaptor Proteins, Signal Transducing; D000072261:Dishevelled Proteins; D010750:Phosphoproteins; D012234:Rho Factor; D051153:Wnt Proteins; D029867:Xenopus Proteins; D051176:beta Catenin