title: Fatal cerebral abscess caused by Cladophialophora bantiana.
abstract: Primary cerebral phaeohyphomycosis is caused by pigmented fungi that exhibit distinct neurotropism often in immunocompetent individuals. A 20-yr-old male presented with multiple brain abscess which was subsequently proven microbiologically to be due to Cladophialophora Bantiana. In spite of near total excision and appropriate antifungal agents succumbed to his illness. We report this case to highlight its rarity and high mortality in an immunocompetent host. There is no initial clinical or laboratory feature that makes a preoperative diagnosis possible and relies on microbiological confirmation.
authors.affiliation: Department of Medicine Unit 1 & Infectious diseases, Christian Medical College & Hospital, Vellore 632004.
authors.forename: I A
authors.initials: IA
authors.lastname: George
authors.forename: Mary S
authors.initials: MS
authors.lastname: Mathews
authors.forename: R
authors.initials: R
authors.lastname: Karthik
authors.forename: Lydia
authors.initials: L
authors.lastname: John
authors.forename: A
authors.initials: A
authors.lastname: Sundar
authors.forename: O C
authors.initials: OC
authors.lastname: Abraham
authors.forename: V
authors.initials: V
authors.lastname: Joseph
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage; D001203:Ascomycota / Q000302:isolation & purification*; D001922:Brain Abscess / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy*; D020314:Central Nervous System Fungal Infections / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy*; D002963:Cladosporium; D003399:Craniotomy; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D005437:Flucytosine / Q000008:administration & dosage; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage; D008297:Male
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B; D005437:Flucytosine