Family history and age at onset of breast cancer in Hispanic and non-Hispanic white women.
OBJECTIVE
To evaluate the association between family history of breast cancer and breast cancer risk among Hispanic and non-Hispanic white (NHW) women.


METHODS
Logistic regression models were used to compute unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) using data collected from the 4-Corners Breast Cancer Study, a population-based case-control study of breast cancer conducted in the Southwest United States (3,074 NHW and 1,647 Hispanic women).


RESULTS
The association between family history of breast cancer and early-onset breast cancer risk differs among NHW and Hispanic women. Among women <50 years old, having a family history of breast cancer was associated with a greater increase in risk among NHWs, with an OR of 2.34 (95% CI: 1.64-3.35) when compared to an OR of 1.32 (95% CI: 0.82-2.19) for Hispanics. This difference in risk was not observed among women 50 years and older, with an OR of 1.69 (95% CI: 1.34-2.13) for NHW and 1.47 (95% CI: 1.03-2.10) for Hispanics.


CONCLUSIONS
Family history of breast cancer poses a greater risk for early-onset breast cancers among NHW when compared to Hispanic women and may reflect ethnic differences in certain predisposing genetic factors that promote breast cancer development.
Risendal
Betsy
B
Department of Preventive Medicine and Biometrics, University of Colorado at Denver and Health Sciences, Aurora, CO 80045, USA. betsy.risendal@uchsc.edu
Hines
Lisa M
LM
Sweeney
Carol
C
Slattery
Martha L
ML
Giuliano
Anna R
AR
Baumgartner
Kathy B
KB
Curtin
Karen
K
Byers
Tim E
TE
D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D000368:Aged; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000208:ethnology* / Q000235:genetics; D016022:Case-Control Studies; D016001:Confidence Intervals; D015986:Confounding Factors, Epidemiologic; D005192:Family Health / Q000208:ethnology*; D005260:Female; D020022:Genetic Predisposition to Disease; D006630:Hispanic or Latino / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D007407:Interviews as Topic; D016015:Logistic Models; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014481:United States / Q000453:epidemiology / Q000208:ethnology; D044465:White People / Q000706:statistics & numerical data*