title: 'Bowenoid wart': wart with bowenoid histological changes? Report of 9 cases.
abstract: BACKGROUND
  Cases of lesions that simulate Bowen's disease have been previously described in the literature.
  
  
  METHODS
  Nine exophytic verruca-like lesions with histological findings of Bowen's disease (BD) are described. All cases had a rapid growth, and were located on the face and neck of elderly patients with chronic solar skin damage. We carried out p16 immunohistochemical staining using the immunoperoxidase technique, which was negative in all cases.
  
  
  CONCLUSIONS
  We think that these 9 lesions are only histologically mimicking BD, and could be a subtype of verruca ('bowenoid wart'). These lesions could be provoked by nononcogenic human papillomavirus (HPV), as in other cases previously described. The p16 staining was negative in all cases, in contrast with most BD cases. It would be interesting to study whether positive p16 staining is related to oncogenic HPV, whereas negative p16 staining could be associated with low or nononcogenic HPV; thus, more studies are needed.
authors.affiliation: Dermatology Department, Virgen de la Arrixaca University Hospital, Carretera Murcia-Cartagena s/n, El Palmar, Murcia, Spain. raulcorb@gmail.com
authors.forename: R
authors.initials: R
authors.lastname: Corbalan-Velez
authors.forename: J A
authors.initials: JA
authors.lastname: Ruiz-Macia
authors.forename: C
authors.initials: C
authors.lastname: Brufau
authors.forename: J
authors.initials: J
authors.lastname: Martinez-Escribano
authors.forename: M
authors.initials: M
authors.lastname: Ara-Martín
authors.forename: F J
authors.initials: FJ
authors.lastname: Carapeto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001913:Bowen's Disease / Q000473:pathology* / Q000601:surgery / Q000821:virology; D005145:Face / Q000473:pathology; D005153:Facial Neoplasms / Q000473:pathology* / Q000601:surgery / Q000821:virology; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009333:Neck / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery / Q000821:virology; D016896:Treatment Outcome; D014860:Warts / Q000473:pathology* / Q000601:surgery / Q000821:virology