Colon cancer: it's CIN or CIMP.
Combined genetic and epigenetic analysis of sporadic colon cancer suggest that it can no longer be viewed as a single disease. There are at least three different subsets with distinct clinico-pathologic features, with important implications for preventions, screening, and therapy.
Issa
Jean-Pierre
JP
University of Texas M. D. Anderson Cancer Center, Houston, TX, USA. jpissa@mdanderson.org
D043171:Chromosomal Instability; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D018899:CpG Islands; D019175:DNA Methylation; D018450:Disease Progression; D044127:Epigenesis, Genetic; D006801:Humans; D019656:Loss of Heterozygosity; D008745:Methylation; D018895:Microsatellite Repeats; D008954:Models, Biological; D008957:Models, Genetic; D009362:Neoplasm Metastasis; D010641:Phenotype; D011379:Prognosis