Herpes zoster with skin lesions and meningitis caused by 2 different genotypes of the Oka varicella-zoster virus vaccine.
A previously healthy boy who had received varicella vaccine developed herpes zoster with meningitis. The vaccine strain recovered from scabs of 3 skin lesions had the wild-type allele at position 108111, a vaccine marker never previously associated with vaccine-associated adverse events. The vaccine strain from cerebrospinal fluid also contained mutations never previously observed at vaccine-associated single nucleotide polymorphisms that would alter amino acid sequences in ORF54 and ORF59. The presence of distinct strains in skin lesions and cerebrospinal fluid indicate that >1 variant strain may reactivate to cause herpes zoster.
Levin
Myron J
MJ
Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80045-0508, USA. myron.levin@uchsc.edu
DeBiasi
Roberta L
RL
Bostik
Vanda
V
Schmid
D Scott
DS
D002644:Chickenpox / Q000517:prevention & control; D019433:Chickenpox Vaccine / Q000009:adverse effects*; D002648:Child; D004279:DNA, Viral / Q000032:analysis / Q000134:cerebrospinal fluid; D014644:Genetic Variation; D005838:Genotype; D006562:Herpes Zoster / Q000209:etiology / Q000821:virology*; D014645:Herpesvirus 3, Human / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008581:Meningitis / Q000821:virology*; D016415:Sequence Alignment; D017193:Skin Diseases, Viral / Q000821:virology
D019433:Chickenpox Vaccine; D004279:DNA, Viral