Modeling of cyclooxygenase-2 and 5-lipooxygenase inhibitory activity of apoptosis-inducing agents potentially useful in prostate cancer chemotherapy: derivatives of diarylpyrazole.
The structure-activity models of the twenty derivatives for COX-2 and ten derivatives of 1,5-diarylpyrazole for 5-LOX inhibitory activity have been investigated using Combinatorial Protocol in Multiple Linear Regression (CP-MLR) with topological descriptors which were calculated from DRAGON software. Among the descriptor classes considered collectively in the study the COX-2 inhibitory activity was, however, correlated with topological (TOPO) and Galvez topological charge indices (GVZ). Modified Burden eigenvalues (BCUT) and 2D autocorrelations (2DAUTO) classes of descriptors have shown correlation to 5-LOX inhibitory activity. The developed models and participating descriptors in them have suggested that the substitutional modification in the diarylpyrazole moiety may have sufficient scope in optimization of prevailing inhibitory activities of these analogues.
Sharma
B K
BK
Department of Chemistry, SK Government College, Sikar, Rajasthan, India. bksharma_sikar@rediffmail.com
Pilania
P
P
Singh
P
P
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D017209:Apoptosis; D001094:Arachidonate 5-Lipoxygenase / Q000378:metabolism; D051546:Cyclooxygenase 2 / Q000378:metabolism; D052246:Cyclooxygenase 2 Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D016014:Linear Models; D016859:Lipoxygenase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D008297:Male; D008956:Models, Chemical; D008958:Models, Molecular; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D011720:Pyrazoles / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D052246:Cyclooxygenase 2 Inhibitors; D016859:Lipoxygenase Inhibitors; D011720:Pyrazoles; D001094:Arachidonate 5-Lipoxygenase; D051546:Cyclooxygenase 2