[Research advancement of bone marrow derived stem cell heterogeneity and its role in intestinal epithelial repair].
OBJECTIVE
To summarize and review the heterogeneity of bone marrow derived stem cells (BMDSCs) and its formation mechanism and significance, and to analyze the possible roles and mechanisms in intestinal epithelial reconstruction.


METHODS
The related literature about BMDSCs heterogeneity and its role in intestinal epithelial repair was reviewed and analyzed.


RESULTS
The heterogeneity of BMDSCs provided better explanations for its multi-potency. The probable mechanisms of BMDSCs to repair intestinal epithelium included direct implantation into intestinal epithelium, fusion between BMDSCs and intestinal stem cells, and promotion of injury microcirculation reconstruction.


CONCLUSIONS
BMDSCs have a bright future in gastrointestinal injury caused by inflammatory bowl disease and regeneration.
Liu
Dengqun
D
College of Preventive Medicine, Institute of Combined Injury, State Key Laboratory of Trauma, Burn and Combined Injury, Third Military Medical University, Chongqing, 400038, P.R. China.
Su
Yongping
Y
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology*; D006801:Humans; D007413:Intestinal Mucosa / Q000502:physiology*; D012038:Regeneration; D013234:Stem Cells / Q000502:physiology*