title: Single-agent lenalidomide induces complete remission of acute myeloid leukemia in patients with isolated trisomy 13.
abstract: Patients with acute myeloid leukemia (AML) frequently fail chemotherapy due to refractory disease, relapse, or toxicity. Among older AML patients (age > 60 years), there are few long-term survivors. Lenalidomide is a candidate for study in AML based on its clinical activity in a related disorder, myelodysplastic syndrome (MDS), with the 5q- chromosomal abnormality. We report induction of sustained morphologic and cytogenetic complete remission in 2 older AML patients treated with high-dose, single-agent lenalidomide; each patient had trisomy 13 as the sole cytogenetic abnormality. We show for the first time that lenalidomide has clinical activity in this poor-risk cytogenetic subset of AML. The clinical trials described in this paper have been registered with www.clinicaltrials.gov under identifiers NCT00466895 and NCT00546897.
authors.affiliation: Department of Internal Medicine, Division of Oncology, Siteman Cancer Center, Washington University, St Louis, MO, USA.
authors.forename: Todd A
authors.initials: TA
authors.lastname: Fehniger
authors.forename: John C
authors.initials: JC
authors.lastname: Byrd
authors.forename: Guido
authors.initials: G
authors.lastname: Marcucci
authors.forename: Camille N
authors.initials: CN
authors.lastname: Abboud
authors.forename: Cheryl
authors.initials: C
authors.lastname: Kefauver
authors.forename: Jacqueline E
authors.initials: JE
authors.lastname: Payton
authors.forename: Ravi
authors.initials: R
authors.lastname: Vij
authors.forename: William
authors.initials: W
authors.lastname: Blum
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics*; D006801:Humans; D000077269:Lenalidomide; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000235:genetics; D008297:Male; D012074:Remission Induction / Q000379:methods; D013792:Thalidomide / Q000008:administration & dosage / Q000031:analogs & derivatives*; D014314:Trisomy / Q000235:genetics*
chemical_list: D000970:Antineoplastic Agents; D013792:Thalidomide; D000077269:Lenalidomide