title: Design, synthesis and RNase A inhibition activity of catechin and epicatechin and nucleobase chimeric molecules.
abstract: Several novel catechin/epicatechin and nucleobase chimeric molecules 1-6 have been synthesized via azide-alkyne click chemistry. The structures of these hybrids have been confirmed by NMR and mass spectroscopic data. The synthesized molecules were tested for their RNase A inhibition activities. Gel-based assays showed inhibition in micromolar concentrations. The extent of inhibition was found to be dependent upon the nature of base as well as the configuration at C-3 position of catechin.
authors.affiliation: Department of Chemistry, Indian Institute of Technology, Kharagpur 721302, India.
authors.forename: Basab
authors.initials: B
authors.lastname: Roy
authors.forename: Sansa
authors.initials: S
authors.lastname: Dutta
authors.forename: Anupma
authors.initials: A
authors.lastname: Choudhary
authors.forename: Anupma
authors.initials: A
authors.lastname: Chowdhary
authors.forename: Amit
authors.initials: A
authors.lastname: Basak
authors.forename: Swagata
authors.initials: S
authors.lastname: Dasgupta
mesh_terms: D000225:Adenine / Q000737:chemistry; D020134:Catalytic Domain; D002392:Catechin / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry / Q000379:methods; D008956:Models, Chemical; D009690:Nucleic Acid Conformation; D012259:Ribonuclease, Pancreatic / Q000037:antagonists & inhibitors*; D013696:Temperature
chemical_list: D002392:Catechin; D012259:Ribonuclease, Pancreatic; D000225:Adenine