[Effect of Danshen root compound on blood lipid and bone biomechanics in mice with hyperlipemia-induced osteoporosis].
OBJECTIVE
To observe the effects of Danshen root compound (DSC) on blood lipid and bone biomechanics in mice with hyperlipemia-induced osteoporosis.


METHODS
Forty Kunming mice were randomized into 5 equal groups, and were given intragastric administration with distilled water (control), lipid emulsion (LE) at the daily dose of 5 ml/kg, LE plus simvastatin, LE plus DSC at 5.0 g/kg (DSC-L group), and LE plus DSC at 10.0 g/kg (DSC-H group), respectively. Serum TC, TG, and HDL-c levels and left femur hydroxyproline, calcium and phosphate contents were measured in the rats, with the right femur taken for bone biomechanical test.


RESULTS
Compared with those in the control group, serum TC, LDL-c and AI of the mice increased and HDL-c, Hyp and bone calcium decreased significantly (P<0.01) with lowered bone biomechanical properties. Compared with those of the LE model group, AI decreased and HDL-c increased significantly in DSC-L and DSC-H groups (P<0.01), and the bone biomechanics in DSC-H group was improved.


CONCLUSIONS
Long-term intragastric administration of lipid emulsion causes lipid metabolic disorder and induces osteoporosis due to hyperlipemia in mice. DSC can significantly increase HDL-c and partially prevent the occurrence of osteoporosis in mice.
Zhang
Zhi-ping
ZP
Department of Histology and Embryology, Guangdong Medical College, Zhanjiang, China. zhangzp93@126.com
You
Ting-ting
TT
Zou
Li-yi
LY
Wu
Tie
T
Wu
Yi
Y
Cui
Liao
L
D000818:Animals; D001696:Biomechanical Phenomena; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006949:Hyperlipidemias / Q000150:complications / Q000188:drug therapy*; D008055:Lipids / Q000097:blood; D008297:Male; D051379:Mice; D010024:Osteoporosis / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D010618:Phenanthrolines / Q000494:pharmacology / Q000627:therapeutic use*; D008517:Phytotherapy; D027561:Salvia miltiorrhiza / Q000737:chemistry
D004365:Drugs, Chinese Herbal; D008055:Lipids; D010618:Phenanthrolines; C028972:dan-shen root extract