title: Randomized trial of very low birth weight infants receiving higher rates of infusion of intravenous fat emulsions during the first week of life.
abstract: OBJECTIVE
  The goal was to determine whether very low birth weight infants could tolerate higher rates of infusion of intravenous fat emulsion during the first week of life and maintain their serum triglyceride levels at <or=200 mg/dL.
  
  
  METHODS
  This was a randomized, controlled trial of 110 infants who were classified as appropriate for gestational age and had birth weights between 750 g and 1500 g. The primary clinical outcome was serum triglyceride levels; secondary outcomes also were monitored.
  
  
  RESULTS
  One hundred infants completed the study (experimental group: N = 48; control group: N = 52). Infants in the experimental group had significantly higher energy intake for the entire 7-day study period and achieved 90 kcal/kg per day (1 kcal = 4.184 kJ) significantly sooner (7.38 +/- 3.381 days vs 9.44 +/- 3.578 days). Triglyceride levels for infants in the experimental group remained significantly higher for the first 5 days of life. Fifteen percent of infants in the experimental group but only 4% of infants in the control group developed hypertriglyceridemia. Ten percent of infants in the control group but no infants in the experimental group required insulin therapy. Forty-two percent of infants in the experimental group and 17% of infants in the control group remained at >or=10th percentile for weight for age. Fourteen percent of infants in the control group but no infants in the experimental group developed necrotizing enterocolitis. Twenty-three percent of infants in the control group but only 6% of infants in the experimental group developed retinopathy of prematurity. There were no significant differences in other outcomes.
  
  
  CONCLUSIONS
  Very low birth weight infants can tolerate higher rates of infusion of intravenous fat emulsion solutions during the first week of life without significant adverse events.
authors.affiliation: Neonatal Intensive Care Unit, Children's Hospital of Illinois, Third Order of St Francis Medical Center, Peoria, IL 61637, USA. douglas.c.drenckpohl@osfhealthcare.org
authors.forename: Douglas
authors.initials: D
authors.lastname: Drenckpohl
authors.forename: Connie
authors.initials: C
authors.lastname: McConnell
authors.forename: Shirley
authors.initials: S
authors.lastname: Gaffney
authors.forename: Matt
authors.initials: M
authors.lastname: Niehaus
authors.forename: Kamlesh S
authors.initials: KS
authors.lastname: Macwan
mesh_terms: D002657:Child Development; D020345:Enterocolitis, Necrotizing / Q000517:prevention & control; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D008297:Male; D011379:Prognosis; D012307:Risk Factors; D014481:United States
chemical_list: D005217:Fat Emulsions, Intravenous