[The impact of mtDNA mutations on proteins structure in selected types of cancer].
Recently published papers report a large number of mitochondrial DNA mutations in many different cancer types, but their significance for electron transport chain proteins remains unknown. This review covers structural mutations of mitochondrial genes, choosing prostate cancer, esophageal cancer and epithelioma as research models. As all mitochondrial genes encode subunits of the electron transport chain, the review focuses on the consequences of structural mutations on cell metabolism.
Plak
Katarzyna
K
Instytut GenetykiiBiotechnologii,WydziałBiologii Uniwersytetu Warszawskiego, Warszawa.
Kukwa
Wojciech
W
Bartnik
Ewa
E
Golik
Paweł
P
Scińska
Anna
A
Krawczyk
Tomasz
T
Czarnecka
Anna M
AM
D000818:Animals; D002277:Carcinoma / Q000235:genetics; D004272:DNA, Mitochondrial / Q000737:chemistry* / Q000235:genetics*; D045222:Electron Transport Chain Complex Proteins / Q000737:chemistry* / Q000378:metabolism*; D004938:Esophageal Neoplasms / Q000235:genetics; D006801:Humans; D008297:Male; D009154:Mutation; D009369:Neoplasms / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000235:genetics
D004272:DNA, Mitochondrial; D045222:Electron Transport Chain Complex Proteins