[The influence of psychoactive substance on histone acetylation modification].
Psychoactive substance abuse and addiction have increasingly become severe, which are not only a serious social problem, but an important medical problem as well. Recent studies have demonstrated that the histone acetylation modification is an important epigenetic mechanism of gene regulations and plays essential roles in psychoactive substance abuse and addiction. The present review mainly presents the influence of several psychoactive substances, including cocaine, amphetamine, methamphetamine, morphine, and alcohol, on histone acetylation modification.
Jing
Li
L
Department of Neuropharmacology, National Institute on Drug Dependence, Peking University, Beijing 100083, China.
Liang
Jian-Hui
JH
D000107:Acetylation / Q000187:drug effects*; D000662:Amphetamines / Q000009:adverse effects; D000818:Animals; D016739:Behavior, Addictive / Q000209:etiology; D003042:Cocaine / Q000009:adverse effects*; D000431:Ethanol / Q000009:adverse effects*; D006657:Histones / Q000378:metabolism*; D006801:Humans; D019966:Substance-Related Disorders / Q000209:etiology
D000662:Amphetamines; D006657:Histones; D000431:Ethanol; D003042:Cocaine