title: An unusual presentation of secondary involvement of B-cell chronic lymphocytic leukemia. A case report.
abstract: Extramammary tumors rarely metastasize to the breast. The commonest tumors to metastasize in breast tissue are lymphoproliferative diseases, melanoma, lung cancer and gynecological malignancies. Primary breast lymphoma has been reported in the literature with a maximum percentage of about 0.5% of all breast malignancies, while secondary localizations of lymphomas in the breast are less well studied in the literature than primary ones. The authors report a rare case of a secondary localization of B-cell chronic lymphocytic leukemia to the breast in which the diagnosis was obtained by histopathology and immunohistochemistry and further confirmed by molecular data. This occurrence must be considered in the differential diagnosis of a breast lump so that the primary hematological disease can be adequately treated and the correct type of breast surgery performed.
authors.affiliation: Division of General Surgery, Department of Human Pathology, University of Messina, Italy. famafausto@yahoo.it
authors.forename: Fausto
authors.initials: F
authors.lastname: Famà
authors.forename: Valeria
authors.initials: V
authors.lastname: Barresi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Giuffrè
authors.forename: Paolo
authors.initials: P
authors.lastname: Todaro
authors.forename: Sergio
authors.initials: S
authors.lastname: Mazzei
authors.forename: Angelo
authors.initials: A
authors.lastname: Vindigni
authors.forename: Maria
authors.initials: M
authors.lastname: Gioffrè-Florio
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis* / Q000556:secondary / Q000601:surgery*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged