title: Structural elucidation of a PDE-5 inhibitor detected as an adulterant in a health supplement.
abstract: A PDE-5 inhibitor was detected and isolated from a health supplement claimed to be a preparation of fresh oyster extracts and be able to promote and support healthy sexual function and endurance, etc. The structure of this PDE-5 inhibitor was elucidated using LC-UV, LC-TOF-MS, MS-MS, IR spectroscopy, and 2D NMR. It was characterized as 8-(2-(4-(hydroxymethyl)piperidin-1-yl)benzylamino)-3-ethyl-1H-imidazo[4,5-g]quinazoline-2(3H)-thione, a compound reported to be a PDE-5 inhibitor.
authors.affiliation: Center for Analytical Sciences, Health Science Authority, 11 Outram Road, Singapore 169078, Singapore.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Ge
authors.forename: Min-Yong
authors.initials: MY
authors.lastname: Low
authors.forename: Peng
authors.initials: P
authors.lastname: Zou
authors.forename: Li
authors.initials: L
authors.lastname: Lin
authors.forename: Sharon Oh Sze
authors.initials: SO
authors.lastname: Yin
authors.forename: Bosco C
authors.initials: BC
authors.lastname: Bloodworth
authors.forename: Hwee-Ling
authors.initials: HL
authors.lastname: Koh
mesh_terms: D002214:Capsules; D002853:Chromatography, Liquid / Q000379:methods; D019587:Dietary Supplements / Q000032:analysis*; D004340:Drug Contamination; D007172:Erectile Dysfunction / Q000178:diet therapy*; D006801:Humans; D007093:Imidazoles / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D013058:Mass Spectrometry / Q000379:methods; D015394:Molecular Structure; D010726:Phosphodiesterase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D011799:Quinazolines / Q000737:chemistry* / Q000302:isolation & purification; D013056:Spectrophotometry, Ultraviolet / Q000379:methods
chemical_list: D002214:Capsules; D007093:Imidazoles; D010726:Phosphodiesterase Inhibitors; D011799:Quinazolines; C443180:KF 31327