title: Phosphoproteomics, oncogenic signaling and cancer research.
abstract: The past 5 years have seen an explosion of phosphoproteomics methods development. In this review, using epidermal growth-factor signaling as a model, we will discuss how phosphoproteomics, along with bioinformatics and computational modeling, have impacted key aspects of oncogenic signaling such as in the temporal fine mapping of phosphorylation events, and the identification of novel tyrosine kinase substrates and phosphorylation sites. We submit that the next decade will see considerable exploitation of phosphoproteomics in cancer research. Such a phenomenon is already happening as exemplified by its use in promoting the understanding of the molecular etiology of cancer and target-directed therapeutics.
authors.affiliation: Oncology Research Institute, Yong Loo Lin School of Medicine, Singapore.
authors.forename: Poh-Kuan
authors.initials: PK
authors.lastname: Chong
authors.forename: Huiyin
authors.initials: H
authors.lastname: Lee
authors.forename: Jacklyn Wai-Fun
authors.initials: JW
authors.lastname: Kong
authors.forename: Marie Chiew-Shia
authors.initials: MC
authors.lastname: Loh
authors.forename: Chee-Hong
authors.initials: CH
authors.lastname: Wong
authors.forename: Yoon-Pin
authors.initials: YP
authors.lastname: Lim
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D019295:Computational Biology; D003198:Computer Simulation; D004815:Epidermal Growth Factor / Q000235:genetics / Q000502:physiology; D066246:ErbB Receptors / Q000235:genetics / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D009857:Oncogenes / Q000502:physiology*; D010750:Phosphoproteins / Q000502:physiology*; D010766:Phosphorylation; D040901:Proteomics / Q000379:methods*; D015398:Signal Transduction
chemical_list: D010750:Phosphoproteins; D004815:Epidermal Growth Factor; D066246:ErbB Receptors