[Preparation and quality evaluation of intravenous tanshinone II (A) emulsion].
OBJECTIVE
To prepare and evaluate an intravenous emulsion of tanshinone II(A).


METHODS
Soybean phospholipid mixing with poloxamer 188 was used as emulsifier. Oleic acid and glycerol were used as co-emulsifier and isoosmotic adjusting agent, respectively. The coarse emulsion was first prepared and following homogenization was carried out for the coarse emulsion by using a high pressure homogenizer.


RESULTS
The average diameter of the prepared tanshinone II (A) emulsion was 211 nm with a zeta potential of -32. 1 mV. There had no changes of diameter, zeta potential, pH value, content and physical appearance for the tanshinone II (A) emulsion stored at 25 degrees C away from light during one year.


CONCLUSIONS
The physicochemical properties of the prepared tanshinone II (A) emulsion was stable, which could meet the requirements of intravenous administration.
Liang
Zhen
Z
West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Mao
Sheng-Jun
SJ
Yin
Zong-Ning
ZN
Jin
Hui
H
Li
Hui
H
Chu
Ting
T
D045784:Abietanes; D002498:Centrifugation; D004355:Drug Stability; D004356:Drug Storage; D004655:Emulsions; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous; D010316:Particle Size; D010616:Phenanthrenes / Q000008:administration & dosage* / Q000737:chemistry*; D011786:Quality Control; D013696:Temperature
D045784:Abietanes; D004655:Emulsions; D010616:Phenanthrenes; C021751:tanshinone