title: Neuregulin 1 ICE-single nucleotide polymorphism in first episode schizophrenia correlates with cerebral activation in fronto-temporal areas.
abstract: The Neuregulin (NRG1) gene has been associated with schizophrenia, but its functional implications are largely unknown. Our aim was to assess differential brain activation between patients carrying an at-risk allele on the Neuregulin 1 gene and patients without this genetic risk. Neural signal changes between 14 first episode schizophrenia patients with the at risk allele (SNP8NRG221533) from the Icelandic core haplotype and 14 without were measured with fMRI during a working memory task. Patients without the at risk allele showed greater activations (P < 0.05; corrected) in the left hippocampus, precuneus and cerebellum, as well as the right anterior cingulate. Brain regions previously associated with the pathology of Schizophrenia are differentially affected in those with a genetic at risk status in the NRG1 gene. Heterogeneity of structural and functional measures within patients characterized by clinical phenotypes may be in part due to this genetic variation.
authors.affiliation: Dept. of Psychiatry and Psychotherapy RWTH , University of Aachen, Pauwelsstr. 30, 52074, Aachen, Germany. tkircher@ukaachen.de
authors.forename: Tilo
authors.initials: T
authors.lastname: Kircher
authors.forename: Renate
authors.initials: R
authors.lastname: Thienel
authors.forename: Michael
authors.initials: M
authors.lastname: Wagner
authors.forename: Martina
authors.initials: M
authors.lastname: Reske
authors.forename: Ute
authors.initials: U
authors.lastname: Habel
authors.forename: Thilo
authors.initials: T
authors.lastname: Kellermann
authors.forename: Ingo
authors.initials: I
authors.lastname: Frommann
authors.forename: Sibylle
authors.initials: S
authors.lastname: Schwab
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Wölwer
authors.forename: Martina
authors.initials: M
authors.lastname: von Wilmsdorf
authors.forename: Dieter F
authors.initials: DF
authors.lastname: Braus
authors.forename: Andrea
authors.initials: A
authors.lastname: Schmitt
authors.forename: Alexander
authors.initials: A
authors.lastname: Rapp
authors.forename: Tony
authors.initials: T
authors.lastname: Stöcker
authors.forename: N Jon
authors.initials: NJ
authors.lastname: Shah
authors.forename: Fritz A
authors.initials: FA
authors.lastname: Henn
authors.forename: Heinrich
authors.initials: H
authors.lastname: Sauer
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Gaebel
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Maier
authors.forename: Frank
authors.initials: F
authors.lastname: Schneider
mesh_terms: D000328:Adult; D002531:Cerebellum / Q000503:physiopathology; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D007839:Functional Laterality / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006179:Gyrus Cinguli / Q000503:physiopathology; D006239:Haplotypes / Q000235:genetics*; D006624:Hippocampus / Q000503:physiopathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D020890:Neuregulin-1 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology*; D013702:Temporal Lobe / Q000503:physiopathology; D055815:Young Adult
chemical_list: D020890:Neuregulin-1