[Formation of the spatial memory in rats with ischemic injury in prefrontal areas of the cortex--effects of a sinthetic analogue of ACTH(4-7)].
It was shown, that photochemically induced thrombosis of blood vessels in prefrontal areas of the cortex lead to the formation of well-defined infarct zone. Bilateral prefrontal cortex injury impair acquisition of the Morris water-maze on postoperative days 20-24. Chronic treatment of brain-injuried rats with peptide semax, a synthetic analogue of ACTH(4-7), at a dose of 250 microg/kg (intranasal, once a day) during six days after photothrombosis resulted in restoration of spatial learning ability. The observed long-lasting antiamnesic effects of the semax are probably caused by its strong neuroprotective action, and ability to induce synthesis of nerotrophic factors.
Silachev
D N
DN
Shram
S I
SI
Shakova
F M
FM
Romanova
G A
GA
Miasoedov
N F
NF
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D020925:Hypoxia-Ischemia, Brain / Q000188:drug therapy / Q000503:physiopathology*; D018782:Maze Learning / Q000187:drug effects; D008568:Memory; D010446:Peptide Fragments / Q000494:pharmacology*; D017397:Prefrontal Cortex / Q000187:drug effects / Q000503:physiopathology*; D051381:Rats; D013028:Space Perception / Q000187:drug effects / Q000502:physiology*
D010446:Peptide Fragments; C048487:ACTH (4-7), Pro-Gly-Pro-; D000324:Adrenocorticotropic Hormone