title: Ultra low fouling zwitterionic polymers with a biomimetic adhesive group.
abstract: Biomimetic polymers with a zwitterionic moiety for ultra low fouling and a catechol end group for surface anchoring have been developed. Binding tests of the adhesive polymers on various surfaces, including amino (NH(2)), hydroxyl (OH), and methyl (CH(3)) terminated self-assembled monolayers (SAMs) along with bare gold, were performed under acidic and basic conditions. Protein adsorption from single protein solutions of fibrinogen, lysozyme, and complex media of 10-100% blood plasma and serum was measured using a surface plasmon resonance (SPR) sensor. Under optimized conditions, the coated surfaces are highly resistant to non-specific protein adsorption from both single protein solutions and blood serum/plasma. Furthermore, the 3-day accumulation of Pseudomonas aeruginosa on the coated surfaces was evaluated in situ in a laminar flow chamber. Results show that the coated surfaces are highly resistant to bacterial adhesion and biofilm formation. This work demonstrates a convenient and efficient method for using zwitterionic polymers with a catechol anchor group to achieve ultra low fouling surfaces via surface modification, for applications in complex media.
authors.affiliation: Department of Chemical Engineering, University of Washington, Seattle, WA 98195, USA.
authors.forename: Guozhu
authors.initials: G
authors.lastname: Li
authors.forename: Gang
authors.initials: G
authors.lastname: Cheng
authors.forename: Hong
authors.initials: H
authors.lastname: Xue
authors.forename: Shengfu
authors.initials: S
authors.lastname: Chen
authors.forename: Fengbao
authors.initials: F
authors.lastname: Zhang
authors.forename: Shaoyi
authors.initials: S
authors.lastname: Jiang
mesh_terms: D000269:Adhesives; D000327:Adsorption; D001422:Bacterial Adhesion; D018441:Biofilms; D040761:Biomimetic Materials; D032701:Biomimetics; D002396:Catechols; D007477:Ions; D008689:Methacrylates; D011506:Proteins / Q000493:pharmacokinetics; D011550:Pseudomonas aeruginosa
chemical_list: D000269:Adhesives; D002396:Catechols; D007477:Ions; D008689:Methacrylates; D011506:Proteins; C521589:sulfobetaine methacrylate polymer; C034221:catechol