Histological analysis of DuraGen in a human subject: case report.
OBJECTIVE
DuraGen (Integra Neurosciences, Plainsboro, NJ, USA) is an avascular collagen matrix used for dural closure. Although, numerous animal models have been studied, histological transformation of DuraGen in humans has not been reported.


METHODS
We analyzed a sample of scarred DuraGen used in a craniectomy patient at time of delayed cranioplasty.


CONCLUSIONS
Histological analysis revealed evidence for both fibroblast infiltration and neovascularization of the DuraGen.
Khorasani
L
L
Division of Pediatric Neurosurgery, Children's Hospital and Regional Medical Center, Seattle, WA, USA.
Kapur
R P
RP
Lee
C
C
Avellino
A M
AM
D000293:Adolescent; D001672:Biocompatible Materials / Q000627:therapeutic use*; D002543:Cerebral Hemorrhage / Q000209:etiology / Q000601:surgery; D003094:Collagen / Q000627:therapeutic use*; D019299:Decompression, Surgical; D004388:Dura Mater / Q000601:surgery*; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications
D001672:Biocompatible Materials; D003094:Collagen