Inherited forms of renal hypomagnesemia: an update.
The kidney plays an important role in ion homeostasis in the human body. Several hereditary disorders characterized by perturbations in renal magnesium reabsorption leading to hypomagnesemia have been described over the past 50 years, with the most important of these being Gitelman syndrome, familial hypomagnesemia with hypercalciuria and nephrocalcinosis, familial hypomagnesemia with secondary hypocalcemia, autosomal dominant hypomagnesemia with hypocalciuria, and autosomal recessive hypomagnesemia. Only recently, following positional cloning strategies in affected families, have mutations in renal ion channels and transporters been identified in these diseases. In this short review, I give an update on these hypomagnesemic disorders. Elucidation of the genetic etiology and, for most of these disorders, also the underlying pathophysiology of the disease, has greatly increased our understanding of the normal physiology of renal magnesium handling. This is yet another example of the importance of studying rare disorders in order to unravel physiological and pathophysiological processes in the human body.
Knoers
Nine V A M
NV
Department of Human Genetics 849, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. n.knoers@antrg.umcn.nl
D053579:Gitelman Syndrome / Q000235:genetics / Q000503:physiopathology; D006801:Humans; D006996:Hypocalcemia / Q000235:genetics / Q000503:physiopathology; D007668:Kidney / Q000378:metabolism*; D007684:Kidney Tubules / Q000378:metabolism; D008274:Magnesium / Q000097:blood*; D008275:Magnesium Deficiency / Q000235:genetics* / Q000503:physiopathology; D008664:Metal Metabolism, Inborn Errors / Q000235:genetics* / Q000503:physiopathology; D050053:TRPM Cation Channels / Q000235:genetics
D050053:TRPM Cation Channels; C459082:TRPM6 protein, human; D008274:Magnesium