Sensitivity-dependent model of protein-protein interaction networks.
The scale free structure p(k)-k(-gamma) of protein-protein interaction networks can be reproduced by a static physical model in simulation. We inspect the model theoretically, and find the key reason for the model generating apparent scale free degree distributions. This explanation provides a generic mechanism of 'scale free' networks. Moreover, we predict the dependence of gamma on experimental protein concentrations or other sensitivity factors in detecting interactions, and find experimental evidence to support the prediction.
Zhang
Jingshan
J
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Shakhnovich
Eugene I
EI
D000465:Algorithms; D003198:Computer Simulation; D008954:Models, Biological; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D013816:Thermodynamics
D011506:Proteins