Prevalence of pancreatic cystic lesions including intraductal papillary mucinous neoplasms in patients with end-stage renal disease on hemodialysis.
OBJECTIVE
Pancreatic cystic (PC) lesions are not necessarily rare, and it is important to diagnose whether PC lesions are neoplastic such as intraductal papillary mucinous neoplasm (IPMN) because of its malignant potential. Reports on PC lesions in hemodialysis (HD) patients are remarkably limited. The aim of this study was to clarify the prevalence and characteristics of PC lesions in HD patients.


METHODS
We reviewed 1012 consecutive HD patients and 11,100 patients (controls) without renal disease who underwent transabdominal ultrasonography between January 2003 and December 2005. Patients' sex ratio (female-to-male) was less, and the age was older in HD patients. Clinical findings of these patients were examined.


RESULTS
The prevalence both of PC lesions and IPMNs was significantly higher in HD patients than in controls (9.3% vs 1.3% and 2.8% vs 0.2%, P < 0.0001). The incidence of IPMNs in HD patients with PC lesions was higher than that in controls with PC lesions (29.8% vs 17.0%, P = 0.021). Multivariate logistic regression analysis revealed that the odds ratios of PC lesions and IPMNs were 6.38 (95% confidence interval, 4.82-8.45) and 9.39 (95% confidence interval, 5.36-16.49) in HD patients compared with controls.


CONCLUSIONS
The prevalence of PC lesions in HD patients is higher, and HD patients with PC lesions have high prevalence of IPMNs.
Ishikawa
Takuya
T
Department of Gastroenterology, Nagoya Kyoritsu Hospital, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Takeda
Kinichi
K
Itoh
Masatsugu
M
Imaizumi
Tadashi
T
Oguri
Kenji
K
Takahashi
Hiroshi
H
Kasuga
Hirotake
H
Toriyama
Takanobu
T
Matsuo
Seiichi
S
Hirooka
Yoshiki
Y
Itoh
Akihiro
A
Kawashima
Hiroki
H
Kasugai
Toshifumi
T
Ohno
Eizaburo
E
Miyahara
Ryoji
R
Ishigami
Masatoshi
M
Katano
Yoshiaki
Y
Ohmiya
Naoki
N
Niwa
Yasumasa
Y
Goto
Hidemi
H
D002288:Adenocarcinoma, Mucinous / Q000453:epidemiology*; D000328:Adult; D000368:Aged; D021441:Carcinoma, Pancreatic Ductal / Q000453:epidemiology*; D002291:Carcinoma, Papillary / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010181:Pancreatic Cyst / Q000453:epidemiology*; D010190:Pancreatic Neoplasms / Q000453:epidemiology*; D015995:Prevalence; D006435:Renal Dialysis