title: Coffee intake and CYP1A2*1F genotype predict breast volume in young women: implications for breast cancer.
abstract: As breast volume may be associated with heart cancer risk, we studied the relationship between breast volume, CYP1A2*1F and coffee intake. Among healthy premenopausal non-hormone users, 3+ cups per day was associated with lower volume only in C-allele carriers (P(interaction)=0.02), which is consistent with reports that coffee protects only C-allele carriers against breast cancer.
authors.affiliation: Department of Oncology, Clinical Sciences, Lund University, Barngatan 2B, SE-221 85 Lund, Sweden. helena.jernstrom@med.lu.se
authors.forename: H
authors.initials: H
authors.lastname: Jernström
authors.forename: M
authors.initials: M
authors.lastname: Henningson
authors.forename: U
authors.initials: U
authors.lastname: Johansson
authors.forename: H
authors.initials: H
authors.lastname: Olsson
mesh_terms: D000328:Adult; D001940:Breast / Q000033:anatomy & histology*; D001943:Breast Neoplasms / Q000517:prevention & control*; D003069:Coffee; D019388:Cytochrome P-450 CYP1A2 / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans
chemical_list: D003069:Coffee; C504573:CYP1A2 protein, human; D019388:Cytochrome P-450 CYP1A2