title: Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs.
abstract: New drugs are needed for treatment of Toxoplasma gondii infections. We tested derivatives of principles found in Isatis indigotica for in vitro efficacy against T. gondii infection. Indirubin-3'-oxime analogs showed modest micromolar activity, while tryptanthrin derivatives displayed 50% inhibitory doses in the low nanomolar range. Tryptanthrins have potential as anti-Toxoplasma infection therapeutics.
authors.affiliation: Dept. of Pediatrics, Johns Hopkins University School of Medicine, 600 N. Wolfe St., Baltimore, MD 21287, USA.
authors.forename: Bogdana
authors.initials: B
authors.lastname: Krivogorsky
authors.forename: Peter
authors.initials: P
authors.lastname: Grundt
authors.forename: Robert
authors.initials: R
authors.lastname: Yolken
authors.forename: Lorraine
authors.initials: L
authors.lastname: Jones-Brando
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology; D031219:Isatis / Q000737:chemistry*; D021261:Parasitic Sensitivity Tests; D011799:Quinazolines / Q000737:chemistry / Q000494:pharmacology*; D014122:Toxoplasma / Q000187:drug effects* / Q000254:growth & development
chemical_list: D000981:Antiprotozoal Agents; D004365:Drugs, Chinese Herbal; D007211:Indoles; D011799:Quinazolines; C046243:tryptanthrine; C027185:indirubin