Association of circulating matrix metalloproteinase-1, but not adiponectin, with advanced coronary artery disease.
OBJECTIVE
Recent evidence suggests that high tissue matrix metalloproteinase-1 (MMP-1) and low adiponectin may serve as biomarkers of atherosclerosis. Results on the associations of circulating MMP-1 and adiponectin concentrations are scarce. We hypothesized that patients with multivessel coronary artery disease (CAD) have elevated high-sensitivity C-reactive protein (hs-CRP), MMP-1 but low adiponectin levels, and concomitant measurements of these biomarkers could improve predictive strength for advanced CAD.


METHODS
We analyzed concentrations of MMP-1, hs-CRP and adiponectin in 217 subjects with angiographically documented multivessel CAD (two-, or three-vessel disease by luminal stenosis >or=50%) and 81 controls. MMP-1 and hs-CRP were notably higher in patients with CAD; while adiponectin was not significantly different between two groups. Levels of hs-CRP positively correlated with body mass index and left ventricular dysfunction (R(2)=0.16, P<0.0001); while adiponectin was significantly associated with age, gender, and levels of cholesterol and triglyceride (R(2)=0.09, P<0.0001). On the contrary, MMP-1 was not associated with any clinical cardiovascular risk factors, and still an independent predictor (OR=1.49, P<0.0001) of multivessel CAD after the adjustment of clinical risk factors and hs-CRP.


CONCLUSIONS
Elevated MMP-1 and hs-CRP, but not low adiponectin concentrations, could predict the presence of advanced coronary atherosclerosis. In addition, MMP-1 may serve as a more specific marker for significant CAD independent of hs-CRP.
Hwang
Juey-Jen
JJ
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Yang
Wei-Shiung
WS
Chiang
Fu-Tien
FT
Chen
Ming-Fong
MF
Lin
Hung-Ju
HJ
Huang
Por-Jau
PJ
Hsu
Sandy Huey-Jen
SH
Lai
Sung-Kuei
SK
Wu
Yen-Wen
YW
D052242:Adiponectin / Q000097:blood; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000000981:diagnostic imaging / Q000201:enzymology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000097:blood*; D008875:Middle Aged; D011237:Predictive Value of Tests
C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D002097:C-Reactive Protein; D020781:Matrix Metalloproteinase 1