title: Spiradenocylindroma-like basaloid carcinoma of the anus and rectum: case report, including HPV studies and analysis of the CYLD gene mutations.
abstract: The authors report a case of basaloid carcinoma involving the anus and rectum of a 57-year-old woman. Microscopically, the tumor showed unusual morphologic features strongly resembling a spiradenocylindroma because it consisted, in most parts, of basaloid cell nodules arranged in a jigsaw-puzzle fashion containing or surrounded by eosinophilic basal membrane material; in addition, there were intratumoral lymphocytes. The overlying squamous epithelium manifested dysplastic changes compatible with in situ squamous carcinoma that gradually became invasive and blended with basaloid cell islands; additionally, there were koilocytes in the squamous epithelium. A molecular biology study identified HPV-16 in the lesional tissue. Analysis of the CYLD gene did not prove any mutation.
authors.affiliation: Sikl's Department of Pathology, Charles University, Medical Faculty Hospital, Pilsen, Czech Republic.
authors.forename: Denisa
authors.initials: D
authors.lastname: Kacerovska
authors.forename: Peter
authors.initials: P
authors.lastname: Szepe
authors.forename: Tomas
authors.initials: T
authors.lastname: Vanecek
authors.forename: Jana
authors.initials: J
authors.lastname: Nemcova
authors.forename: Michal
authors.initials: M
authors.lastname: Michal
authors.forename: Petr
authors.initials: P
authors.lastname: Mukensnabl
authors.forename: Dmitry V
authors.initials: DV
authors.lastname: Kazakov
mesh_terms: D001005:Anus Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000821:virology; D003528:Carcinoma, Adenoid Cystic / Q000175:diagnosis / Q000473:pathology* / Q000821:virology; D002280:Basal Cell Carcinoma / Q000175:diagnosis / Q000473:pathology* / Q000821:virology; D000074749:Deubiquitinating Enzyme CYLD; D003937:Diagnosis, Differential; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D052162:Human papillomavirus 16 / Q000472:pathogenicity*; D006801:Humans; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D012004:Rectal Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000821:virology; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000821:virology; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D025521:Tumor Suppressor Proteins; C409984:CYLD protein, human; D000074749:Deubiquitinating Enzyme CYLD