title: Location of collateral sprouting of donor nerve following end-to-side neurorrhaphy.
abstract: Various studies have demonstrated collateral regeneration of the donor nerve following end-to-side neurorrhaphy, but the location of collateral sprouting remains controversial. In a rat end-to-side neurorrhaphy model we isolated nerve fibers from the donor nerve at the neurorrhaphy site utilizing a micro-tease technique. We found that axons sprouted collaterally from a myelinated nerve fiber at the node of Ranvier. Based on this preliminary result we conclude that myelinated nerve fibers could sprout collateral branches at the node of Ranvier at an end-to-side neurorrhaphy site. These findings show that end-to-side neurorrhaphy may be an alternative for peripheral nerve repair.
authors.affiliation: Division of Microsurgery and Orthopedic Trauma, the First Affiliated Hospital at Sun Yat-Sen University, 58 Zhongsan Er Road, Guangzhou, Guangdong 510080, China.|Orthopedic Surgery Program, California Hospital Medical Center, Los Angeles, California, USA.
authors.forename: Qing-Tang
authors.initials: QT
authors.lastname: Zhu
authors.affiliation: Division of Microsurgery and Orthopedic Trauma, the First Affiliated Hospital at Sun Yat-Sen University, 58 Zhongsan Er Road, Guangzhou, Guangdong 510080, China.
authors.forename: Jia-Kai
authors.initials: JK
authors.lastname: Zhu
authors.affiliation: Orthopedic Surgery Program, California Hospital Medical Center, Los Angeles, California, USA.|Department of Orthopedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
authors.forename: Gary Y
authors.initials: GY
authors.lastname: Chen
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D008297:Male; D009416:Nerve Regeneration / Q000502:physiology*; D019635:Neurosurgical Procedures / Q000379:methods*; D010523:Peripheral Nervous System Diseases / Q000601:surgery*; D051381:Rats; D017208:Rats, Wistar; D019651:Plastic Surgery Procedures / Q000379:methods*; D013536:Suture Techniques