title: [Chronic obstructive pulmonary disease and genetics].
abstract: Chronic obstructive pulmonary disease (COPD) is characterised by airflow limitation and is associated with an inflammatory response of the lungs primarily caused by cigarette smoking. Cigarette smoking is by far the most important environmental risk factor for COPD, but less than half of all heavy smokers develop COPD. This indicates a genetic contribution to the individual disease susceptibility. Although many genes have been examined, the puzzle of COPD genetics seems still largely unsolved. It is therefore important to measure phenotypes and to perform genome-wide scans of COPD patients in order to unravel the contribution of the COPD susceptibility genes.
authors.affiliation: Bispebjerg Hospital, Lungemedicinsk Forskningsenhed, Lungemedicinsk afdeling L. ting0003@bbh.regionh.dk
authors.forename: Truls
authors.initials: T
authors.lastname: Ingebrigtsen
authors.forename: Simon Francis
authors.initials: SF
authors.lastname: Thomsen
authors.forename: Jørgen
authors.initials: J
authors.lastname: Vestbo
authors.forename: Vibeke
authors.initials: V
authors.lastname: Backer
mesh_terms: D020022:Genetic Predisposition to Disease; D006801:Humans; D029424:Pulmonary Disease, Chronic Obstructive / Q000209:etiology / Q000235:genetics*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects