title: Impact upon clinical outcomes of translation of PNA FISH-generated laboratory data from the clinical microbiology bench to bedside in real time.
abstract: Fluorescence in situ hybridization using peptide nucleic acid probes (PNA-FISH) differentiates Staphylococcus aureus from other Gram-positive-cocci in clusters (GPCC). 101/202 patients with GPCC+ blood cultures were randomly assigned to clinician-notification of PNA FISH results. Notification was associated with reduced mortality (8% vs.17%, p = 0.05), further antibiotic use (median -2.5 days, p = 0.01), and trended toward reduced hospital stay and charges.
authors.affiliation: Section of Infectious Diseases, Washington Hospital Center Washington DC, USA.
authors.forename: Tam
authors.initials: T
authors.lastname: Ly
authors.forename: Jyoti
authors.initials: J
authors.lastname: Gulia
authors.forename: Vasilios
authors.initials: V
authors.lastname: Pyrgos
authors.forename: Masashi
authors.initials: M
authors.lastname: Waga
authors.forename: Shmuel
authors.initials: S
authors.lastname: Shoham