Antifungal activities of human beta-defensins HBD-1 to HBD-3 and their C-terminal analogs Phd1 to Phd3.
The activities of defensins HBD-1, HBD-2, and HBD-3 and their C-terminal analogs Phd1, Phd2, and Phd3 against Candida albicans were investigated. Phd1 to Phd3 showed lower-level activities than HBD-1 to HBD-3, although metabolic inhibitors did not render Phd1 to Phd3 inactive. Their activities were also less salt sensitive than those of HBD-1 to HBD-3. Confocal microscope images indicated that the initial site of action was the fungal membrane.
Krishnakumari
Viswanatha
V
Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Hyderabad, India.
Rangaraj
Nandini
N
Nagaraj
Ramakrishnan
R
D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D006801:Humans; D023083:beta-Defensins / Q000737:chemistry / Q000494:pharmacology*
D000935:Antifungal Agents; C406407:DEFB1 protein, human; C422950:DEFB103A protein, human; D023083:beta-Defensins