Microwave-assisted parallel synthesis of fused heterocycles in a novel parallel multimode reactor.
New rotor types using disposable glass vials for small-scale parallel synthesis in multimode microwave reactors are introduced. One rotor comprises 16 groups of four vials, whereas the second uses four silicon carbide plates with a 6 x 4 matrix to process the vials. Both rotors achieve utmost temperature homogeneity upon microwave irradiation and can be used for microwave-mediated reactions at temperatures of up to 200 degrees C and pressures of 20 bar. The generation of three different heterocycle libraries furnishing thiophenes, oxindoles, and benzimidazoles using the new rotor types is described.
Treu
Matthias
M
Boehringer Ingelheim Austria GmbH, Dr. Boehringer Gasse 5-11, A-1121 Vienna, Austria.
Karner
Thomas
T
Kousek
Roland
R
Berger
Helmut
H
Mayer
Moriz
M
McConnell
Darryl B
DB
Stadler
Alexander
A
D020650:Combinatorial Chemistry Techniques / Q000295:instrumentation*; D004867:Equipment Design; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D008872:Microwaves; D054852:Small Molecule Libraries / Q000138:chemical synthesis; D013696:Temperature
D006571:Heterocyclic Compounds; D054852:Small Molecule Libraries