Metformine for psychosis associated with the menstrual cycle in a patient with polycystic ovary syndrome.
There are several reports of periodic psychotic disorders that appear in connection with the various phases of the menstrual cycle. Although the pathogenesis of menstrual psychosis has not been systematically investigated, it appears that it might be linked to an estrogen cascade that follows a period of sustained high estrogen levels, as in the case in anovulatory cycles. We present a case of psychosis associated with the menstrual cycle in a patient with polycystic ovary syndrome, a disorder typically characterized by anovulatory cycles, in whom the restoration of normal menstruation with use of metformine led to significant improvement of psychotic symptoms.
Andreou
Christina
C
1st Psychiatric Department, Aristotle University of Thessaloniki, Thessaloniki, Greece, chrandre@auth.gr
Syngelakis
Markos
M
Karavatos
Athanasios
A
D000374:Aggression / Q000187:drug effects; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D008598:Menstruation / Q000523:psychology; D008687:Metformin / Q000008:administration & dosage*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000188:drug therapy* / Q000523:psychology*; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000523:psychology; D011644:Puerperal Disorders / Q000188:drug therapy* / Q000523:psychology; D055815:Young Adult
D007004:Hypoglycemic Agents; D008687:Metformin