Obesity-related nephropathy associated with a history of IgA nephropathy.
This report describes the case of a 57-year-old man who underwent a repeated renal biopsy 25 years after the first biopsy in which the diagnosis of IgA nephropathy was made. Although the patient exhibited gradually increasing proteinuria and a slowly progressive renal impairment, the histological findings of the repeat biopsy revealed no evidence of either glomerular inflammatory changes or IgA deposition. Instead, a marked decrease in the glomerular density and hypertrophy of the remnant glomeruli were noted. Almost a complete disappearance of urinary protein excretion by a calorie-restricted diet indicated that the patient's obesity and its related factors may have contributed to the present nephropathic development.
Tsuboi
Nobuo
N
Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo. nobuotsuboi@aol.com
Kawamura
Tetsuya
T
Ishii
Takeo
T
Hosoya
Tatsuo
T
D004038:Diet, Reducing; D005922:Glomerulonephritis, IGA / Q000150:complications*; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000178:diet therapy; D013997:Time Factors