title: Scaffold diversity of natural products: inspiration for combinatorial library design.
abstract: Natural products contain scaffold structures that can be systematically exploited for the design of combinatorial compound libraries with druglike properties. We review approaches for scaffold identification, and compare properties and pharmacophoric features of drugs and natural products. In particular, an application of the self-organizing map technique is presented for natural product-derived compound and library design.
authors.affiliation: Institute of Organic Chemistry and Chemical Biology, ZAFES/CMP, Goethe-University, Siesmayerstrasse 70, Frankfurt a.M., Germany.
authors.forename: Kristina
authors.initials: K
authors.lastname: Grabowski
authors.forename: Karl-Heinz
authors.initials: KH
authors.lastname: Baringhaus
authors.forename: Gisbert
authors.initials: G
authors.lastname: Schneider
mesh_terms: D001688:Biological Products; D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D015394:Molecular Structure
chemical_list: D001688:Biological Products