[Relationship between apolipoprotein e4 allele and emergence agitation in patients undergoing general anesthesia].
OBJECTIVE
To investigate the relationship between apolipoprotein e4 allele and emergence agitation (EA) in patients undergoing general anesthesia.


METHODS
A nested cohort study was conducted in elderly patients (over 60 years old) scheduled for major abdominal surgery requiring general anesthesia. A structured interview was conducted in PACU to determine EA, defined using the Sedation-Agitation Scale (SAS). Blood samples were obtained for measurement of the apolipoprotein genotypes.


RESULTS
Of the 196 patients studied, 22.4% developed EA. Thirty-eight patients (19.4%) had the apolipoprotein e4 allele. The presence of the e4 allele and low level of education were both associated with an increased risk of EA (36.9% vs15.8%, P=0.005; 30% vs 14.3%, P=0.01). After adjustment for covariates, the patients with the copy of e4 allele were shown to have a greater likeliness of an increased risk of EA (odds ratio: 4.32; 95% CI: 1.75-10.05) than those without the e4 allele.


CONCLUSIONS
Apolipoprotein e4 carrier status is associated with an increased risk for EA.
Zhang
Shuang-quan
SQ
Department of Anesthesiology, Third Affiliated Hospital of Guangzhou Medical College, Guangzhou, China.
Wang
Gang
G
Yu
Wei
W
Zhan
Hong
H
Chen
Hao-wen
HW
D000005:Abdomen / Q000601:surgery; D000368:Aged; D000483:Alleles; D000762:Anesthesia Recovery Period; D000768:Anesthesia, General / Q000009:adverse effects / Q000379:methods*; D053327:Apolipoprotein E4 / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011595:Psychomotor Agitation / Q000209:etiology / Q000235:genetics*; D012307:Risk Factors
D053327:Apolipoprotein E4