Juvenile pityriasis rubra pilaris: report of 28 cases in Taiwan.
BACKGROUND
Pityriasis rubra pilaris (PRP) is a papulosquamous dermatosis uncommon in juveniles. Large-scale studies are limited, especially from Asian countries.


OBJECTIVE
We sought to analyze the clinical manifestations of juvenile PRP in Taiwanese patients and compare them with reported series in the literature.


METHODS
The diagnosis of juvenile PRP was made based on clinical-histopathologic correlation. The therapeutic response and disease course were followed up by re-examination of the patients or by telephone.


RESULTS
A total of 47 patients were identified, with histopathologic confirmation of the clinical diagnosis of juvenile PRP in 28 cases. A preponderance of Griffiths' type IV PRP (85.7%) rather than type III PRP (14.3%) was found. Palmoplantar hyperkeratosis appeared to be a cardinal feature. In patients with type IV PRP, skin lesions in areas other than the elbows/knees and palms/soles were common. Treatment with systemic acitretin in 6 patients failed to effect a dose- or time-dependent improvement. In contrast with other studies, two thirds of our patients with type III and IV juvenile PRP had a protracted course lasting more than 3 years.


CONCLUSIONS
This study was a retrospective review. Patient compliance with treatment was frequently poor.


CONCLUSIONS
Type IV juvenile PRP predominated but our cases showed a wider distribution of skin lesions than is typically described. When children present with an acute onset of diffuse palmoplantar hyperkeratosis, a diagnosis of juvenile PRP should be considered. Because of the divergent clinical manifestations of juvenile PRP in different populations, there is a need to modify and re-evaluate classification systems based on regional differences.
Yang
Chao-Chun
CC
Department of Dermatology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Shih
I-Hsin
IH
Lin
Wan-Lung
WL
Yu
Yi-Sheng
YS
Chiu
Hsien-Ching
HC
Huang
Po-Han
PH
Cheng
Yu-Wen
YW
Lee
Julia Yu-Yun
JY
Chen
WenChieh
W
D017255:Acitretin / Q000627:therapeutic use; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010916:Pityriasis Rubra Pilaris / Q000188:drug therapy / Q000453:epidemiology* / Q000473:pathology; D012189:Retrospective Studies; D013624:Taiwan / Q000453:epidemiology
D017255:Acitretin