title: Reduction of peritoneal adhesion to polypropylene mesh with the application of fibrin glue.
abstract: OBJECTIVE
  The purpose of our study was to evaluate the possibility of the reduction of peritoneal adhesions to a polypropylene mesh with fibrin glue.
  
  
  METHODS
  Forty Wistar rats were assigned to two treatment groups: Group 1) hernioplasty with polypropylene mesh plus fibrin glue sealant, and Group 2) hernioplasty with polypropylene mesh without fibrin glue sealant. The variables evaluated were: presence and density of adhesion, organs or abdominal structures adhered to the polypropylene mesh, inflammatory tissular reaction and cell recount.
  
  
  RESULTS
  Group 1 presented a statistically lower adhesion percentage than Group 2 (40% versus 100%, P = 0.0003). The mean areas of mesh patch surfaces covered with adhesions were statistically different between Groups 1 and 2 (0.67 +/- 0.65 cm2 versus 1.60 +/- 0.51 cm2; P = 0.00001). Twelve rats presented with adhesions in Group 1; eleven were adhesions to the epiploon and one to the colon. In Group 2 there were 16 adhesions to the epiploon, 2 to the colon, 1 to the small intestine and 1 to the stomach. Tissular reaction comparison showed a significant difference (21 +/- 4.9 versus 17 +/- 4.1; P = 0.006).
  
  
  CONCLUSIONS
  Fibrin glue sealant significantly reduced the frequency and severity of intra-abdominal adhesions.
authors.affiliation: Departamento de Cirugía y Unidad de Investigación en Epidemiología Clínica Hospital General Zona y Medicina Familiar No. 1, Instituto Mexicano del Seguro Social, Colima, México.
authors.forename: E
authors.initials: E
authors.lastname: Prieto-Díaz-Chávez
authors.forename: J Luis
authors.initials: JL
authors.lastname: Medina-Chávez
authors.forename: E J
authors.initials: EJ
authors.lastname: Ramírez-Barba
authors.forename: B
authors.initials: B
authors.lastname: Trujillo-Hernández
authors.forename: R O
authors.initials: RO
authors.lastname: Millán-Guerrero
authors.forename: C
authors.initials: C
authors.lastname: Vásquez
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D046449:Hernia, Abdominal / Q000601:surgery*; D010537:Peritoneum / Q000601:surgery*; D011126:Polypropylenes; D011183:Postoperative Complications / Q000517:prevention & control; D051381:Rats; D017208:Rats, Wistar; D013526:Surgical Mesh; D000267:Tissue Adhesions / Q000517:prevention & control*; D014014:Tissue Adhesives / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D015718:Fibrin Tissue Adhesive; D011126:Polypropylenes; D014014:Tissue Adhesives