Inflammation and the neurovascular unit in the setting of focal cerebral ischemia.
Responses to focal cerebral ischemia by neurons and adjacent microvessels are rapid, simultaneous, and topographically related. Recent observations indicate the simultaneous appearance of proteases by components of nearby microvessels that are also expressed by neurons in the ischemic territory, implying that the events could be coordinated. The structural relationship of neurons to their microvascular supply, the direct functional participation of glial cells, and the observation of a highly ordered microvessel-neuron response to ischemia suggest that these elements are arranged in and behave in a unitary fashion, the neurovascular unit. Their roles as a unit in the stimulation of cellular inflammation and the generation of inflammatory mediators during focal cerebral ischemia have not been explored yet. However, components of the neurovascular unit both generate and respond to these influences under the conditions of ischemia. Here we briefly explore the potential inter-relationships of the components of the neurovascular unit with respect to their potential roles in ischemia-induced inflammatory responses.
del Zoppo
G J
GJ
Department of Medicine, University of Washington, Box 359756, Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104, USA. grdlzop@u.washington.edu
D000818:Animals; D001485:Basement Membrane / Q000276:immunology / Q000473:pathology; D001812:Blood-Brain Barrier / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D002545:Brain Ischemia / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D002196:Capillaries / Q000276:immunology* / Q000503:physiopathology; D002450:Cell Communication / Q000276:immunology; D004660:Encephalitis / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D042783:Endothelial Cells / Q000276:immunology; D006801:Humans; D008833:Microcirculation / Q000276:immunology*; D009457:Neuroglia / Q000276:immunology*; D009474:Neurons / Q000276:immunology*