[Regulatory effect of microbial alkyloxybenzenes of different structure on the stress response of yeast].
The effect of alkyloxybenzenes (AHBs) belonging to the class of alkylresorcinols differing in the degree of hydrophobicity--C7-AHB and more hydrophobic Cl12-AHB--on the resistance of Saccharomyces cerevisiae cells to heat shock and oxidative stress of lethal intensity was studied. Depending on structure and concentration, AHB added 2 h before exposure to stress had either an antistress or stress-potentiating effect on yeast cells in the mid-logarithmic growth phase. C7-AHB at concentrations 0.25-0.5 g/l caused a two- to fivefold increase in the resistance of yeast cells to hydrogen peroxide (30-150 mM), whereas Cl2-AHB reduced it at all concentrations. C7-AHB and Cl2-AHB had a similar effect on yeast subjected to heat shock (45 degrees C, 30 min). It was found that the degree of the protective effect of C7-AHB and potentiating effect of Cl2-AHB depended on the nature of the stressor, being more pronounced in heat shock. The environmental significance of the antistress and stress-potentiating effects of microbial AHBs is discussed.
Konanykhina
I A
IA
Shanenko
E F
EF
Loĭko
N G
NG
Nikolaev
Iu A
IuA
El'-Registan
G I
GI
D001555:Benzene Derivatives / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D018869:Heat-Shock Response / Q000187:drug effects* / Q000502:physiology; D006861:Hydrogen Peroxide / Q000494:pharmacology; D057927:Hydrophobic and Hydrophilic Interactions; D016877:Oxidants / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000254:growth & development*; D013329:Structure-Activity Relationship
D001555:Benzene Derivatives; D016877:Oxidants; D006861:Hydrogen Peroxide