Dermatomyositis associated with hepatitis B virus-related hepatocellular carcinoma.
Dermatomyositis (DM) is an idiopathic inflammatory myopathy (IIM) with typical cutaneous manifestations. It has been proposed that DM may be caused by autoimmune responses to viral infections, and previous studies have also shown that an association between DM and malignancy. However, chronic hepatitis B virus (HBV) infection associated with DM and hepatocellular carcinoma (HCC) is rarely encountered. The authors report a case of DM and HCC in a patient with a HBV infection. A 58-year-old man presented erythematous skin rashes on a sun-exposed area of 2 year's duration, and recent proximal muscle weakness. His medical history revealed that he had a chronic HBV infection. A diagnosis of DM relies on proximal muscle weakness, elevated muscle enzymes, myopathic changes (demonstrated by electromyography), muscle biopsy evidence of myositis, and its characteristic cutaneous findings. A Liver mass in the left lobe visualized by abdominal computed tomography was confirmed histologically as HCC. This case suggests that DM associated with HCC might be caused by a HBV infection.
Kee
Seung-Jung
SJ
Department of Laboratory Medicine, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea.
Kim
Tae-Jong
TJ
Lee
Sung-Ji
SJ
Cho
Young-Nan
YN
Park
Seong-Chang
SC
Kim
Jong-Sun
JS
Kim
Jeong-Chul
JC
Kang
Hyung-Sik
HS
Lee
Shin-Seok
SS
Park
Yong-Wook
YW
D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000473:pathology / Q000821:virology*; D003882:Dermatomyositis / Q000175:diagnosis* / Q000821:virology*; D017809:Fatal Outcome; D006515:Hepatitis B virus / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000821:virology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011859:Radiography