title: Vitiligo-like primary melanoma.
abstract: Depigmented or hypopigmented macules and patches have been described in association to primary and metastatic melanoma. Primary melanoma presenting at the onset as a vitiliginous patch without histopathological evidence of regression seems to be a rare event. We report 2 patients with melanoma in situ that expressed clinically as vitiligo-like patches and review the possible immunologic mechanisms responsible for this unusual presentation.
authors.affiliation: Department of Dermatology, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.
authors.forename: Aída
authors.initials: A
authors.lastname: Lugo-Somolinos
authors.forename: Jorge L
authors.initials: JL
authors.lastname: Sánchez
authors.forename: María E
authors.initials: ME
authors.lastname: Garcia
mesh_terms: D000368:Aged; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008544:Melanocytes / Q000276:immunology / Q000473:pathology; D008545:Melanoma / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology*; D012867:Skin / Q000276:immunology / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology*; D012880:Skin Pigmentation / Q000276:immunology; D014820:Vitiligo / Q000175:diagnosis