Metal-free Michael addition initiated multicomponent oxidative cyclodehydration route to polysubstituted pyridines from 1,3-dicarbonyls.
A simple metal-free, step-economic and selective access to pyridines from readily available substrates is reported, involving a flexible 4 A molecular sieves promoted Michael addition initiated domino three-component reaction between a 1,3-dicarbonyl, a Michael acceptor and a synthetic equivalent of ammonia.
Liéby-Muller
Frédéric
F
Aix-Marseille Université, Institut des Sciences Moléculaires de Marseille, Marseille Cedex 20, France.
Allais
Christophe
C
Constantieux
Thierry
T
Rodriguez
Jean
J
D003500:Cyclization; D007659:Ketones / Q000737:chemistry*; D010084:Oxidation-Reduction; D011725:Pyridines / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
D007659:Ketones; D011725:Pyridines; D014867:Water