title: Microwave-assisted palladium-catalyzed cross-coupling of aryl and vinyl halides with H-phosphonate diesters.
abstract: A general and efficient method for the microwave-assisted formation of the C-P bond was developed. Using a prevalent palladium catalyst, Pd(PPh3)4, a quantitative cross-coupling of various H-phosphonate diesters with aryl and vinyl halides was achieved in less than 10 min. The reactions occurred with retention of configuration at the phosphorus center and in the vinyl moiety. Using this protocol, several C-phosphonates, including those bearing nucleoside and cholesteryl moieties, were prepared in high yields.
authors.affiliation: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, S-106 91 Stockholm, Sweden.
authors.forename: Marcin
authors.initials: M
authors.lastname: Kalek
authors.forename: Asraa
authors.initials: A
authors.lastname: Ziadi
authors.forename: Jacek
authors.initials: J
authors.lastname: Stawinski
mesh_terms: D002384:Catalysis; D004952:Esters / Q000737:chemistry*; D006219:Halogens / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008872:Microwaves; D015394:Molecular Structure; D063065:Organophosphonates / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D012997:Solvents; D014753:Vinyl Compounds / Q000737:chemistry*
chemical_list: D004952:Esters; D006219:Halogens; D063065:Organophosphonates; D012997:Solvents; D014753:Vinyl Compounds; D010165:Palladium; D006859:Hydrogen