MicroRNAs in embryonic stem cells.
The unique properties of embryonic stem cells (ESCs) to self-renew indefinitely or to differentiate to any cell type have great potential for clinical applications in regenerative medicine. MicroRNAs (miRNAs) are emerging as important regulators of post-transcriptional gene expression and have been implicated as crucial elements in regulating ESCs. Here, we review recent progresses in characterizing the role of miRNAs in the maintenance and development of ESCs.
Wang
Yulei
Y
Gene Expression and Genotyping Assays R&D, Molecular Cell Biology Division, Applied Biosystems, Foster City, California, USA.
Keys
David N
DN
Au-Young
Janice K
JK
Chen
Caifu
C
D000818:Animals; D019070:Cell Lineage; D053595:Embryonic Stem Cells / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*
D035683:MicroRNAs