Pancreatic stellate cells and pancreatic cancer cells: an unholy alliance.
Pancreatic cancer--a tumor displaying a particularly abundant stromal reaction--is notorious for its poor prognosis. Recent studies, via newly developed orthotopic models, provide compelling evidence of an important role for pancreatic stellate cells (PSC) in pancreatic cancer progression. Characterization of the mechanisms mediating PSC-cancer interactions will lead to the development of much needed alternative therapeutic approaches to improve disease outcome.
Vonlaufen
Alain
A
Pancreatic Research Group, South Western Sydney Clinical School and School of Medical Sciences/Pathology, The University of New South Wales and Sydney, Sydney, NSW, Australia.
Phillips
Phoebe A
PA
Xu
Zhihong
Z
Goldstein
David
D
Pirola
Romano C
RC
Wilson
Jeremy S
JS
Apte
Minoti V
MV
D000818:Animals; D049109:Cell Proliferation; D018450:Disease Progression; D006801:Humans; D008954:Models, Biological; D010179:Pancreas / Q000166:cytology* / Q000502:physiology; D010190:Pancreatic Neoplasms / Q000209:etiology / Q000473:pathology*; D017154:Stromal Cells / Q000502:physiology*