title: Chronic myeloid leukemia following chemotherapy with 5'-deoxy-5-fluorouridine for gastric cancer.
abstract: We report here a very rare case of chronic myeloid leukemia (CML) following long-term chemotherapy with 5'-deoxy-5-fluorouridine (5'-DFUR) for gastric cancer. A 69-year-old man was diagnosed with the chronic phase of CML. Six years previously, he underwent radical subtotal gastrectomy for gastric cancer, and was subsequently treated with oral anti-metabolite 5'-DFUR as adjuvant chemotherapy for 6 years. He was placed on imatinib therapy, and achieved a major molecular response 10 months after the initiation of therapy. This is the first reported case of therapy-related CML following 5'-DFUR treatment.
authors.affiliation: Department of Medicine, Fujita Health University, School of Medicine, Toyoake. mtsuzuki@fujita-hu.ac.jp
authors.forename: Motohiro
authors.initials: M
authors.lastname: Tsuzuki
authors.forename: Kousuke
authors.initials: K
authors.lastname: Handa
authors.forename: Kiyoko
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Akio
authors.initials: A
authors.lastname: Hasegawa
authors.forename: Yukiya
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Masato
authors.initials: M
authors.lastname: Watanabe
authors.forename: Syuichi
authors.initials: S
authors.lastname: Mizuta
authors.forename: Fumio
authors.initials: F
authors.lastname: Maruyama
authors.forename: Masataka
authors.initials: M
authors.lastname: Okamoto
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Emi
authors.forename: Kohji
authors.initials: K
authors.lastname: Ezaki
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D005467:Floxuridine / Q000009:adverse effects*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000209:etiology*; D008297:Male; D016609:Neoplasms, Second Primary / Q000209:etiology*; D013274:Stomach Neoplasms / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D000964:Antimetabolites, Antineoplastic; D005467:Floxuridine; C025034:doxifluridine