title: Efficacy of enamel matrix derivatives (Emdogain) in treatment of replanted teeth--a systematic review based on animal studies.
abstract: The objective of the current systematic review was to evaluate the efficacy of enamel matrix derivative (EMD) (Emdogain) on healing of replanted or autotransplanted permanent teeth. A review of the published literature [search term: (Emdogain OR enamel matrix derivative OR enamel matrix protein] AND [avulsion OR replantation OR autotransplantation)] was conducted by two independent investigators according to defined selection criteria. For data extraction of the identified animal studies, the following histomorphometric findings were considered: (i) healed PDL, (ii) surface resorption, (iii) inflammatory resorption and (iv) replacement resorption. The heterogeneity of data collection and the small amount of identified publications did not allow for statistical analysis. Four controlled trials (CT) conducted in animals, but no randomized controlled trials (RCT) or clinical controlled trials (CCT) could be received from the systematic search. From the selected studies, two CT gave evidence of EMD treatment to be effective in inducing healing of replanted teeth, while one CT found no differences between EMD treated teeth and controls. Finally, one CT compared EMD and sodium fluoride application, but revealed no differences between the treatments. The data of controlled trials available are limited and conflicting. No firm conclusion regarding the efficacy of EMD application on healing of replanted or autotransplanted permanent teeth can be drawn because of lack of RCT and CCT.
authors.affiliation: Clinic for Preventive Dentistry, Periodontology and Cariology, University of Zürich, Zürich, Switzerland. annette.wiegand@zzmk.unizh.ch
authors.forename: Annette
authors.initials: A
authors.lastname: Wiegand
authors.forename: Thomas
authors.initials: T
authors.lastname: Attin
mesh_terms: D000818:Animals; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D018865:Dental Research / Q000379:methods; D010513:Periodontal Ligament / Q000502:physiology; D012391:Root Resorption / Q000517:prevention & control*; D012969:Sodium Fluoride / Q000627:therapeutic use; D014084:Tooth Avulsion / Q000601:surgery*; D014090:Tooth Replantation
chemical_list: D003746:Dental Enamel Proteins; C109069:enamel matrix proteins; D012969:Sodium Fluoride