[Condition of oxidation homeostasis and possibility of its correction in experimental rheumatoid arthritis].
The data on condition of oxidation homeostasis in experimental rheumatoid joint inflammation in rabbits are presented. Against a background of expressed local and general activity of the inflammatory process in the synovial medium of the affected joint, the peroxide-antioxidative imbalance (increase of level ofmalonic dialdehyde and the activity of ceruloplasmin) and also lowering of pH and pO2, rise of lactate blood level are detected. The intraarticular introduction of the antioxidant ceruloplasmin promoted the normalization of synovial medium of affected joints.
Belova
S V
SV
Kariakina
E V
EV
D000818:Animals; D001169:Arthritis, Experimental / Q000097:blood*; D001172:Arthritis, Rheumatoid / Q000097:blood*; D002570:Ceruloplasmin / Q000378:metabolism*; D006706:Homeostasis; D006861:Hydrogen Peroxide / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid / Q000097:blood*; D010084:Oxidation-Reduction; D011817:Rabbits; D013582:Synovial Fluid / Q000378:metabolism*
D019344:Lactic Acid; D006861:Hydrogen Peroxide; D002570:Ceruloplasmin