title: Amino-terminal pro-brain natriuretic peptid in prediction of left ventricular ejection fraction.
abstract: We aimed to evaluate levels of amino-terminal pro-brain natriuretic peptid (NT-proBNP) in prediction of left ventricular ejection fraction (LVEF) in heart failure patients. Prospective study on 60 consecutive patients with symptoms and signs of heart failure was performed. Blood samples for NT-proBNP analysis was taken from all test subjects and echocardiography was also done in all of them. According to LVEF value, patients were divided into four groups; those with <or=30%, 31 to 39%, 40 to 49% and >or=50%. NT-proBNP values correlated with LVEF value. Regression analysis was used to evaluate how well NT-proBNP values predict LVEF. We used Receiver Operating Characteristic Curve calculation to evaluate diagnostic performance of NT-proBNP in estimation of LVEF. Average value of NT-proBNP in test group was 3191.69+/-642.89 pg/ml (p<0.001). Average value of NT-proBNP decreased with higher LVEF categories with significant (p<0.001) and high negative correlation (r= -0,75). Stepwise multivariate linear regression analysis showed that logarithmic value of NT-proBNP was excellent predictor of LVEF value (p<0.05). Model equation based on regression analysis was LVEF=88.645-15.311 x log (NT-proBNP). Predictive model for LVEF yielded from regression analysis had sensitivities of 98% and 81%, specificities of 20% and 90%, positive predictive values of 86% and 78% and negative predictive values of 67% and 92% for predicting patients with LVEF<50% and LVEF<40%, respectively. There was negative linear correlation between NT-proBNP and LVEF. NT-proBNP was excellent predictor of LVEF value (p<0.05).
authors.affiliation: Internal Clinic, University Clinical Center, Trnovac bb, 75000 Tuzla, Bosnia and Herzegovina.
authors.forename: Mugdim
authors.initials: M
authors.lastname: Bajrić
authors.forename: Fahir
authors.initials: F
authors.lastname: Baraković
authors.forename: Zumreta
authors.initials: Z
authors.lastname: Kusljugić
authors.forename: Nermin
authors.initials: N
authors.lastname: Salkić
authors.forename: Elmir
authors.initials: E
authors.lastname: Jahić
authors.forename: Mensura
authors.initials: M
authors.lastname: Ascerić
authors.forename: Farid
authors.initials: F
authors.lastname: Ljuca
authors.forename: Denis
authors.initials: D
authors.lastname: Mrsić
authors.forename: Elnur
authors.initials: E
authors.lastname: Smajić
authors.forename: Jasmin
authors.initials: J
authors.lastname: Caluk
authors.forename: Ramiz
authors.initials: R
authors.lastname: Hajrić
mesh_terms: D000368:Aged; D002908:Chronic Disease; D005260:Female; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012044:Regression Analysis; D012680:Sensitivity and Specificity; D013318:Stroke Volume / Q000502:physiology*; D016276:Ventricular Function
chemical_list: D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain