Tyrianthinic acids from Ipomoea tyrianthina and their antimycobacterial activity, cytotoxicity, and effects on the central nervous system.
Four new partially acylated tetrasaccharides of 11-hydroxyhexadecanoic acid (1-4) were isolated from a methanolic extract of Ipomoea tyrianthina. The structures of these compounds were elucidated by spectroscopic and chemical methods. The resin glycoside composition of I. tyrianthina varied with the location of growth in Mexico. Compounds 1-4 showed antimycobacterial activity, were cytotoxic against the KB cell line, and, in a mouse model, exhibited potentiation of hypnosis induced by pentobarbital, protected against seizures induced by pentylenetetrazole, and released GABA and glutamic acid.
León-Rivera
Ismael
I
Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, Mexico. ismaelr@ciq.uaem.mx
Mirón-López
Gumersindo
G
Molina-Salinas
Gloria María
GM
Herrera-Ruiz
Maribel
M
Estrada-Soto
Samuel
S
del Carmen Gutiérrez
María
M
Alonso-Cortes
Daniel
D
Navarrete-Vázquez
Gabriel
G
Ríos
María Yolanda
MY
Said-Fernández
Salvador
S
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002490:Central Nervous System / Q000187:drug effects*; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D027741:Ipomoea / Q000737:chemistry*; D007624:KB Cells; D008800:Mexico; D051379:Mice; D023421:Models, Animal; D009844:Oligosaccharides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D010424:Pentobarbital / Q000494:pharmacology; D010433:Pentylenetetrazole / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014376:Tuberculosis / Q000188:drug therapy*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000972:Antineoplastic Agents, Phytogenic; D000995:Antitubercular Agents; D009844:Oligosaccharides; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D010424:Pentobarbital; D010433:Pentylenetetrazole