title: Hemodynamic wall shear stress profiles influence the magnitude and pattern of stenosis in a pig AV fistula.
abstract: Venous stenosis is a significant problem in arteriovenous fistulae, likely due to anatomical configuration and wall shear stress profiles. To identify linkages between wall shear stress and the magnitude and pattern of vascular stenosis, we produced curved and straight fistulae in a pig model. A complete wall stress profile was calculated for the curved configuration and correlated with luminal stenosis. Computer modeling techniques were then used to derive a wall shear stress profile for the straight arteriovenous fistula. Differences in the wall shear stress profile of the curved and straight fistula were then related to histological findings. There was a marked inverse correlation between the magnitude of wall shear stress within different regions of the curved arteriovenous fistula and luminal stenosis in these same regions. There were also significantly greater differences in wall shear stress between the outer and inner walls of the straight as compared to curved arteriovenous fistula, which translated into a more eccentric histological pattern of intima-media thickening. Our results suggest a clear linkage between anatomical configuration, wall shear stress profiles, and the pattern of luminal stenosis and intima-media thickening in a pig model of arteriovenous fistula stenosis. These results suggest that fistula failure could be reduced by using computer modeling prior to surgical placement to alter the anatomical and, consequently, the wall shear stress profiles in an arteriovenous fistula.
authors.affiliation: Cincinnati Dialysis Access Research Program, Department of Mechanical, Industrial, and Nuclear Engineering, University of Cincinnati, Cincinnati, Ohio 45267-0585, USA.
authors.forename: Mahesh K
authors.initials: MK
authors.lastname: Krishnamoorthy
authors.forename: Rupak K
authors.initials: RK
authors.lastname: Banerjee
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zhang
authors.forename: Abhijit
authors.initials: A
authors.lastname: Sinha Roy
authors.forename: Saeb F
authors.initials: SF
authors.lastname: Khoury
authors.forename: Lois J
authors.initials: LJ
authors.lastname: Arend
authors.forename: Steve
authors.initials: S
authors.lastname: Rudich
authors.forename: Prabir
authors.initials: P
authors.lastname: Roy-Chaudhury
mesh_terms: D000818:Animals; D001164:Arteriovenous Fistula / Q000209:etiology*; D003198:Computer Simulation; D003251:Constriction, Pathologic / Q000209:etiology*; D004195:Disease Models, Animal; D006439:Hemodynamics / Q000502:physiology*; D013314:Stress, Mechanical; D013552:Swine