title: Ratio of lethal and edema factors in rabbit systemic anthrax.
abstract: Bacillus anthracis secretes two binary toxins: lethal toxin (PA + LF) and edema toxin (PA + EF) that play a major role in the pathogenesis of anthrax. Their activities can synergize or interfere among each other, depending on the cell type. It is therefore fundamental to know their concentration ratio in vivo. Here, we report the first determination of the concentration ratio of anthrax toxin components LF/EF in the serum of rabbits infected with B. anthracis spores.
authors.affiliation: Dipartimento di Scienze Biomediche- CNR Istituto di Neuroscienze, viale G. Colombo 3, 35121 Padova, Italy.
authors.forename: Federica Dal
authors.initials: FD
authors.lastname: Molin
authors.forename: Antonio
authors.initials: A
authors.lastname: Fasanella
authors.forename: Morena
authors.initials: M
authors.lastname: Simonato
authors.forename: Giuliano
authors.initials: G
authors.lastname: Garofolo
authors.forename: Cesare
authors.initials: C
authors.lastname: Montecucco
authors.forename: Fiorella
authors.initials: F
authors.lastname: Tonello
mesh_terms: D000818:Animals; D000881:Anthrax / Q000382:microbiology*; D000942:Antigens, Bacterial / Q000097:blood* / Q000633:toxicity; D001408:Bacillus anthracis / Q000472:pathogenicity; D001427:Bacterial Toxins / Q000097:blood* / Q000633:toxicity; D015153:Blotting, Western; D016014:Linear Models; D011817:Rabbits
chemical_list: D000942:Antigens, Bacterial; D001427:Bacterial Toxins; C030325:anthrax toxin