title: Association of circulating matrix metalloproteinase-1, but not adiponectin, with advanced coronary artery disease.
abstract: OBJECTIVE
  Recent evidence suggests that high tissue matrix metalloproteinase-1 (MMP-1) and low adiponectin may serve as biomarkers of atherosclerosis. Results on the associations of circulating MMP-1 and adiponectin concentrations are scarce. We hypothesized that patients with multivessel coronary artery disease (CAD) have elevated high-sensitivity C-reactive protein (hs-CRP), MMP-1 but low adiponectin levels, and concomitant measurements of these biomarkers could improve predictive strength for advanced CAD.
  
  
  METHODS
  We analyzed concentrations of MMP-1, hs-CRP and adiponectin in 217 subjects with angiographically documented multivessel CAD (two-, or three-vessel disease by luminal stenosis >or=50%) and 81 controls. MMP-1 and hs-CRP were notably higher in patients with CAD; while adiponectin was not significantly different between two groups. Levels of hs-CRP positively correlated with body mass index and left ventricular dysfunction (R(2)=0.16, P<0.0001); while adiponectin was significantly associated with age, gender, and levels of cholesterol and triglyceride (R(2)=0.09, P<0.0001). On the contrary, MMP-1 was not associated with any clinical cardiovascular risk factors, and still an independent predictor (OR=1.49, P<0.0001) of multivessel CAD after the adjustment of clinical risk factors and hs-CRP.
  
  
  CONCLUSIONS
  Elevated MMP-1 and hs-CRP, but not low adiponectin concentrations, could predict the presence of advanced coronary atherosclerosis. In addition, MMP-1 may serve as a more specific marker for significant CAD independent of hs-CRP.
authors.affiliation: Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Juey-Jen
authors.initials: JJ
authors.lastname: Hwang
authors.forename: Wei-Shiung
authors.initials: WS
authors.lastname: Yang
authors.forename: Fu-Tien
authors.initials: FT
authors.lastname: Chiang
authors.forename: Ming-Fong
authors.initials: MF
authors.lastname: Chen
authors.forename: Hung-Ju
authors.initials: HJ
authors.lastname: Lin
authors.forename: Por-Jau
authors.initials: PJ
authors.lastname: Huang
authors.forename: Sandy Huey-Jen
authors.initials: SH
authors.lastname: Hsu
authors.forename: Sung-Kuei
authors.initials: SK
authors.lastname: Lai
authors.forename: Yen-Wen
authors.initials: YW
authors.lastname: Wu
mesh_terms: D052242:Adiponectin / Q000097:blood; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000000981:diagnostic imaging / Q000201:enzymology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000097:blood*; D008875:Middle Aged; D011237:Predictive Value of Tests
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D002097:C-Reactive Protein; D020781:Matrix Metalloproteinase 1