[Neonatal bronchopulmonary dysplasia: morphogenesis, morphological diagnosis].
Four groups of changes (premorbid, paradysplastic, nonspecific, and pathognomonic) have been detected in the lung of 64 dead children w ith neonatal bronchopulmonary dysplasia (NBPD) on artificial ventilation (AV) for an average of 20 +/- 0.1 days. In the latter group, the authors have identified the key structures that reflect the pathogenetic action of aggressive factors of AV and that are diagnostic markers of the 4 detected stages of NBPD morphogenesis: bronchiolectasis and stellar atelectasis (Stage 1); rosette-like bronchioli (Stage 2); mosaic pneumosclerosis and fibroatelectases (stellate, moire, and fibromuscular) (Stage 3); and honeycomb lung (Stage 4).
Samokhin
P A
PA
Tsvetkova
Iu V
IuV
D001980:Bronchi / Q000473:pathology*; D001997:Bronchopulmonary Dysplasia / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008168:Lung / Q000473:pathology*; D008297:Male