title: Intelligence of very preterm or very low birthweight infants in young adulthood.
abstract: OBJECTIVE
  To examine the effect of intrauterine and neonatal growth, prematurity and personal and environmental risk factors on intelligence in adulthood in survivors of the early neonatal intensive care era.
  
  
  METHODS
  A large geographically based cohort comprised 94% of all babies born alive in the Netherlands in 1983 with a gestational age below 32 weeks and/or a birth weight >1500 g (POPS study). Intelligence was assessed in 596 participants at 19 years of age. Intrauterine and neonatal growth were assessed at birth and 3 months of corrected age. Environmental and personal risk factors were maternal age, education of the parent, sex and origin.
  
  
  RESULTS
  The mean (SD) IQ of the cohort was 97.8 (15.6). In multiple regression analysis, participants with highly educated parents had a 14.2-point higher IQ than those with less well-educated parents. A 1 SD increase in birth weight was associated with a 2.6-point higher IQ, and a 1-week increase in gestational age was associated with a 1.3-point higher IQ. Participants born to young mothers (<25 years) had a 2.7-point lower IQ, and men had a 2.1-point higher IQ than women. The effect on intelligence after early (symmetric) intrauterine growth retardation was more pronounced than after later (asymmetric) intrauterine or neonatal growth retardation. These differences in mean IQ remained when participants with overt handicaps were excluded.
  
  
  CONCLUSIONS
  Prematurity as well as the timing of growth retardation are important for later intelligence. Parental education, however, best predicted later intelligence in very preterm or very low birthweight infants.
authors.affiliation: Division of Neonatology, Department of Pediatrics, Erasmus MC-Sophia Children's Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands. n.weisglas@erasmusmc.nl
authors.forename: N
authors.initials: N
authors.lastname: Weisglas-Kuperus
authors.forename: E T M
authors.initials: ET
authors.lastname: Hille
authors.forename: H J
authors.initials: HJ
authors.lastname: Duivenvoorden
authors.forename: M J J
authors.initials: MJ
authors.lastname: Finken
authors.forename: J M
authors.initials: JM
authors.lastname: Wit
authors.forename: S
authors.initials: S
authors.lastname: van Buuren
authors.forename: J B
authors.initials: JB
authors.lastname: van Goudoever
authors.forename: S P
authors.initials: SP
authors.lastname: Verloove-Vanhorick
mesh_terms: D002657:Child Development; D015331:Cohort Studies; D004522:Educational Status; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D007360:Intelligence; D008297:Male; D008423:Maternal Age; D009426:Netherlands / Q000453:epidemiology; D012307:Risk Factors; D055815:Young Adult