title: The Chitranjan Ranawat Award: functional outcome after total knee replacement varies with patient attributes.
abstract: Total knee replacement effectively relieves arthritis pain but improvement in physical function varies. A clearer understanding of the patient attributes associated with differing levels of functional gain after TKR is critical to surgical decision making. We reviewed 8050 primary, unilateral TKR patients enrolled in a prospective registry between 2000 and 2005 who had complete data. We evaluated associations between 12-month function (SF12/PCS) and preoperative gender, age, BMI, emotional health (MCS), knee diagnosis, quadriceps strength, and physical function (PCS). More than 98% of patients reported pain relief (KS pain score). At 12 months, mean PCS gain was 13.6 points, but the distribution was bimodal. The mean gain in PCS in the 63% of patients with greater improvement was 21 (SD = 7), and 4.1 (SD = 7) in the remaining 37%. Increased likelihood of poor functional gain was associated with older age, body mass index (BMI) over 40, lower MCS, and poor quadriceps strength. While two-thirds of patients reported functional gain well above national average at 12 months post-TKR, 37% reported limited functional improvement. Further understanding of the patient attributes associated with limited improvement will guide the design of innovative strategies to improve functional outcomes.
  
  
  METHODS
  Level II, prognostic study. See the Guidelines for Authors for a complete description of levels of evidence.
authors.affiliation: Department of Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School, Worcester, MA 01655, USA.
authors.forename: Patricia D
authors.initials: PD
authors.lastname: Franklin
authors.forename: Wenjun
authors.initials: W
authors.lastname: Li
authors.forename: David C
authors.initials: DC
authors.lastname: Ayers
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018771:Arthralgia / Q000503:physiopathology* / Q000534:rehabilitation; D019645:Arthroplasty, Replacement, Knee / Q000379:methods*; D001363:Awards and Prizes; D015992:Body Mass Index; D004185:Disability Evaluation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009985:Orthopedics; D020370:Osteoarthritis, Knee / Q000503:physiopathology / Q000534:rehabilitation / Q000601:surgery*; D010147:Pain Measurement; D016059:Range of Motion, Articular / Q000502:physiology*; D012189:Retrospective Studies; D012955:Societies, Medical; D013997:Time Factors; D016896:Treatment Outcome; D016138:Walking / Q000502:physiology*