title: Impact of different doses of lead on internal organs of quails.
abstract: Lead (Pb) is the most ancient poison known to man. In the present study, amount of accumulation of Pb in liver, kidney, ovary and testes of rain quail was studied using different doses of lead. Spectrophotometric analysis of heavy metal treated organs was carried out to determine the amount of metal accumulation in these organs. LD50 value was 4 ppm. Dose of lead was given in three ranges of low, medium and high. It was observed that testes (< or =6.8 x 10(-6)) mgkg(-1)day(-1) and ovary (< or =7.5 x 10(-6)) mgkg(-1)day(-1), accumulated low amount from different doses when given continuously for 21 days. In contrast to this, liver (< or =9.2 x 10(-6)) mgkg(-1)day(-1) and kidney (< or =9.3 x 10(-6)) mgkg(-1)day(-1) accumulated the maximum amount of metal when treated for the same number of days. This study is quite unique and astonishing as the period for intoxication is short (21 days) as compared to the long ones (91 days and above). Our results show that generally metal accumulation is highest in liver, while it is low in gonad.
authors.affiliation: Department of Civil Engineering, Indian Institute of Technology, Kanpur, India. vandanam@iitk.ac.in
authors.forename: Vandana
authors.initials: V
authors.lastname: Mehrotra
authors.forename: V L
authors.initials: VL
authors.lastname: Saxena
authors.forename: A K
authors.initials: AK
authors.lastname: Saxena
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D007668:Kidney; D007854:Lead / Q000493:pharmacokinetics* / Q000633:toxicity*; D007855:Lead Poisoning / Q000662:veterinary*; D008099:Liver; D008297:Male; D010053:Ovary; D011784:Quail / Q000502:physiology*; D012989:Soil Pollutants / Q000493:pharmacokinetics / Q000633:toxicity; D013053:Spectrophotometry; D013737:Testis; D013997:Time Factors; D014018:Tissue Distribution; D018675:Toxicity Tests; D014874:Water Pollutants, Chemical / Q000493:pharmacokinetics / Q000633:toxicity
chemical_list: D012989:Soil Pollutants; D014874:Water Pollutants, Chemical; D007854:Lead