title: [Randomized controlled study on effects of the needling method for regulating spleen-stomach on coronary heart disease complicated by type 2 diabetes mellitus complicated].
abstract: OBJECTIVE
  To probe into the clinical therapeutic effect of acupuncture on coronary heart disease complicated by type 2 diabetes mellitus (CDM) and the mechanism.
  
  
  METHODS
  Using multi-central, randomized, controlled and blind methods, 120 cases of CDM were divided into an observation group and a control group, 60 cases in each group. They were treated by routine therapy for diabetes mellitus, and in the observation group, acupuncture at Quchi (LI 11), Hegu (LI 4), Xuehai (SP 10), Zusanli (ST 36), Yinlingquan (SP 9), Fenglong (ST 40). Diji (SP 8), Sanyinjiao (SP 6), etc. were added with the needling method for regulating spleen-stomach; while in the control group, acupuncture was given at Weiwanxiashu (EX-B 3), Feishu (BL 13), Pishu (BL 20), Shenshu (BL 23), Yanglingquan (GB 34), etc. The treatment was given twice a day in the two groups. Clinical therapeutic effects were assessed according to clinical symptoms and signs, frequency and lasting time of angina pectoris, quantity of taking Glycerol Trinitrate, blood sugar, blood lipids, urinary albumin excretion rate, urinary beta2-microglobulin, urinary monocyte chemotactic protein-1 (MCP-1), ECG, heart color Doppler, etc.
  
  
  RESULTS
  The needling method for regulating spleen-stomach not only could improve the symptoms and signs of the patient, but also could improve the degree of ST segment moving down and the function of left artrium relaxation, and had benign regulative effect on glycometabolism, lipids metabolism and urinary albumin level, with significant differences as compared with the control group (P < 0.05 or P < 0.01). The markedly effective rate for improvement of ECG was 50.00% in the observation group and 13.79% in the control group.
  
  
  CONCLUSIONS
  The needling method for regulating spleen-stomach can improve the damage of heart and blood vessels induced by abnormal sugar and lipids, decrease the level of urinary protein, inhibit MCP-1 excessive expression, relieve myocardial load and raise cardiac output in the patient of coronary heart disease complicated by type 2 diabetes mellitus.
authors.affiliation: Department of Acupuncture and Moxibustion, Tianjin City Hospital of TCM, Tianjin 300140, China zhangzhilongtj@yahoo.com.cn
authors.forename: Zhi-Long
authors.initials: ZL
authors.lastname: Zhang
authors.forename: Xue-Qun
authors.initials: XQ
authors.lastname: Ji
authors.forename: Shu-Hua
authors.initials: SH
authors.lastname: Zhao
authors.forename: Jing-Jiang
authors.initials: JJ
authors.lastname: Zhang
authors.forename: Tao
authors.initials: T
authors.lastname: Kang
authors.forename: Xiu-Juan
authors.initials: XJ
authors.lastname: Yang
mesh_terms: D015670:Acupuncture Therapy / Q000379:methods*; D000368:Aged; D003327:Coronary Disease / Q000628:therapy*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D013154:Spleen / Q000503:physiopathology; D013270:Stomach / Q000503:physiopathology