title: Immune-mediated audiovestibular disorders in the paediatric population: a review.
abstract: Recent studies show that several audiovestibular pathologies in the paediatric population may be immune-mediated. This is even more probable if the pathology is associated with a coexisting systemic autoimmune disorder. At this time, however, the current literature is limited to a few case reports, and little is known with regard to prevalence, diagnosis, and management of immune-mediated inner-ear disorders in children. This review aims to shed some light on clinical presentation, diagnosis, and treatment of paediatric immune-mediated inner-ear disorders. Sudden and progressive sensorineural hearing loss is discussed, in addition to some of the systemic autoimmune disorders commonly associated with immune-mediated audiovestibular pathology such as Cogan's syndrome, systemic lupus erythematosus, Behcet's disease, Sjogren's syndrome, and juvenile idiopathic arthritis.
authors.affiliation: Department of Neuro-otology, The National Hospital of Neurology and Neurosurgery, London, UK. c.agrup@ion.ucl.ac.uk
authors.forename: Charlotte
authors.initials: C
authors.lastname: Agrup
mesh_terms: D001327:Autoimmune Diseases / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D002648:Child; D034381:Hearing Loss / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D012307:Risk Factors; D016896:Treatment Outcome; D015837:Vestibular Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D014722:Vestibule, Labyrinth / Q000276:immunology*
chemical_list: D007166:Immunosuppressive Agents