title: Simulation of blood flow in a small-diameter vascular graft model with a swirl (spiral) flow guider.
abstract: Small-diameter vascular grafts are in large demand for coronary and peripheral bypass procedures, but present products still fail in long-term clinical application. In the present communication, a new type of small-diameter graft with a swirl flow guider was proposed to improve graft patency rate. Flow pattern in the graft was simulated numerically and compared with that in a conventional graft. The numerical results revealed that the swirl flow guider could indeed make the blood flow rotate in the new graft. The swirling flow distal to the flow guider significantly altered the flow pattern in the new graft and the velocity profiles were re-distributed. Due to the swirling flow, the blood velocity near the vessel wall and wall shear rate were greatly enhanced. We believe that the increased blood velocity near the wall and the wall shear rate can impede the occurrence of acute thrombus formation and intimal hyperplasia, hence can improve the graft patency rate for long-term clinical use.
authors.affiliation: Department of Bioengineering, Beihang University, Beijing, 100083, China.
authors.forename: ZhiGuo
authors.initials: Z
authors.lastname: Zhang
authors.forename: YuBo
authors.initials: Y
authors.lastname: Fan
authors.forename: XiaoYan
authors.initials: X
authors.lastname: Deng
authors.forename: GuiXue
authors.initials: G
authors.lastname: Wang
authors.forename: He
authors.initials: H
authors.lastname: Zhang
authors.forename: Robert
authors.initials: R
authors.lastname: Guidoin
mesh_terms: D001783:Blood Flow Velocity; D001807:Blood Vessel Prosthesis; D003198:Computer Simulation; D008954:Models, Biological