Assembly system of direct modified superparamagnetic iron oxide nanoparticles for target-specific MRI contrast agents.
We report the direct modification of SPIOs with a biomolecule and the target-specific assembly system of these modified SPIOs for using MRI contrast agents. The transverse relaxation rate of the aqueous solutions containing the modified SPIOs was altered by the dispersion state.
Tanaka
Kazuo
K
Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
Kitamura
Narufumi
N
Morita
Masahito
M
Inubushi
Toshiro
T
Chujo
Yoshiki
Y
D052157:Aptamers, Nucleotide / Q000737:chemistry; D001710:Biotin / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003287:Contrast Media / Q000737:chemistry / Q000494:pharmacology*; D004247:DNA / Q000737:chemistry; D015195:Drug Design; D005290:Ferric Compounds / Q000737:chemistry*; D006427:Hemin / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008024:Ligands; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D013997:Time Factors
D052157:Aptamers, Nucleotide; D003287:Contrast Media; D005290:Ferric Compounds; D008024:Ligands; C000499:ferric oxide; D001710:Biotin; D006427:Hemin; D004247:DNA