title: Iron supplementation during treatment with erythropoiesis-stimulating agents for cancer-related anemia.
abstract: Unresponsiveness to erythropoiesis-stimulating agents is a major limitation to the treatment of chemotherapy-related anemia. This is often related to a disregulation of iron metabolism leading to functional iron deficiency. However, the use of iron supplementation during treatment with erythropoiesis-stimulating agents has not been as rigorously pursued in anemic patients with cancer as it has in chronic kidney disease. In this article, we review and discuss the role of iron supplementation in the setting of chemotherapy-related anemia in view of recently published clinical trials addressing this issue.
authors.affiliation: Oncologia Medica Falck, Ospedale Niguarda Ca' Granda, Milano, Italy. ilaria.schiavetto@ospedaleniguarda.it
authors.forename: Ilaria
authors.initials: I
authors.lastname: Schiavetto
authors.forename: Paolo
authors.initials: P
authors.lastname: Pedrazzoli
authors.forename: Vera
authors.initials: V
authors.lastname: Basilico
authors.forename: Salvatore
authors.initials: S
authors.lastname: Siena
mesh_terms: D000740:Anemia / Q000139:chemically induced / Q000188:drug therapy*; D019587:Dietary Supplements; D006397:Hematinics / Q000627:therapeutic use*; D006801:Humans; D007501:Iron / Q000627:therapeutic use*; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D006397:Hematinics; D007501:Iron