Transient lesion in the splenium of the corpus callosum due to carbamazepine.
Keeping in mind that lesions located in the splenium of the corpus callosum can sometimes be temporary may help us avoid invasive diagnostic and therapeutic methods. Transient lesion in the splenium of the corpus related to using or withdrawal of antiepileptic drugs are rarely encountered. In this article, we present a non-epileptic patient found to have a centrally located isolated lesion in the splenium of the corpus callosum on the tenth day following the sudden withdrawal of carbamazepine after two weeks of use. The lesion was observed to disappear two months later and the carbamazepine treatment or sudden withdrawal of the drug was thought to be responsible for this reversible splenial lesion.
Güven
Hayat
H
Dişkapi Training and Research Hospital, Neurology, Ankara, Turkey.
Delibaş
Sennur
S
Comoğlu
Selim Selçuk
SS
D000927:Anticonvulsants / Q000009:adverse effects*; D002220:Carbamazepine / Q000009:adverse effects*; D003337:Corpus Callosum / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D011602:Psychophysiologic Disorders / Q000188:drug therapy; D012640:Seizures / Q000188:drug therapy; D013375:Substance Withdrawal Syndrome / Q000473:pathology*; D055815:Young Adult
D000927:Anticonvulsants; D002220:Carbamazepine