New methods for stereochemical determination of complex polyketides: configurational assignment of novel metabolites from myxobacteria.
An overview on recently developed methods for the stereochemical determination of complex polyketides is given and NMR-spectroscopic, computational, biosynthetic and synthetic methods are discussed. These methods are presented in their applications to structurally novel polyketide classes from myxobacteria.
Menche
Dirk
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Department of Organic Chemistry, University of Heidelberg, Heidelberg, Germany. dirk.menche@oci.uni-heidelberg.de
D018942:Macrolides / Q000737:chemistry* / Q000302:isolation & purification*; D015394:Molecular Structure; D009231:Myxococcales / Q000737:chemistry* / Q000378:metabolism; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism
D018942:Macrolides