title: [Relationship between apolipoprotein e4 allele and emergence agitation in patients undergoing general anesthesia].
abstract: OBJECTIVE
  To investigate the relationship between apolipoprotein e4 allele and emergence agitation (EA) in patients undergoing general anesthesia.
  
  
  METHODS
  A nested cohort study was conducted in elderly patients (over 60 years old) scheduled for major abdominal surgery requiring general anesthesia. A structured interview was conducted in PACU to determine EA, defined using the Sedation-Agitation Scale (SAS). Blood samples were obtained for measurement of the apolipoprotein genotypes.
  
  
  RESULTS
  Of the 196 patients studied, 22.4% developed EA. Thirty-eight patients (19.4%) had the apolipoprotein e4 allele. The presence of the e4 allele and low level of education were both associated with an increased risk of EA (36.9% vs15.8%, P=0.005; 30% vs 14.3%, P=0.01). After adjustment for covariates, the patients with the copy of e4 allele were shown to have a greater likeliness of an increased risk of EA (odds ratio: 4.32; 95% CI: 1.75-10.05) than those without the e4 allele.
  
  
  CONCLUSIONS
  Apolipoprotein e4 carrier status is associated with an increased risk for EA.
authors.affiliation: Department of Anesthesiology, Third Affiliated Hospital of Guangzhou Medical College, Guangzhou, China.
authors.forename: Shuang-quan
authors.initials: SQ
authors.lastname: Zhang
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Yu
authors.forename: Hong
authors.initials: H
authors.lastname: Zhan
authors.forename: Hao-wen
authors.initials: HW
authors.lastname: Chen
mesh_terms: D000005:Abdomen / Q000601:surgery; D000368:Aged; D000483:Alleles; D000762:Anesthesia Recovery Period; D000768:Anesthesia, General / Q000009:adverse effects / Q000379:methods*; D053327:Apolipoprotein E4 / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011595:Psychomotor Agitation / Q000209:etiology / Q000235:genetics*; D012307:Risk Factors
chemical_list: D053327:Apolipoprotein E4