title: Diaphyseal sclerotic osteosarcoma presenting as a pathological fracture.
abstract: A diaphyseal, intramedullary, highly sclerotic lesion presenting as a pathological fracture, without a periosteal reaction or an appreciable soft tissue component on radiographs was investigated. A discrepancy between the MRI and histopathological findings led to marginal excision of the lesion only to reveal later that it was a sclerotic variety of osteosarcoma. Such a presentation has not been reported in literature as per our knowledge. We forfeited the opportunity of limb salvage by doing initial marginal excision and fixation. In such circumstances, a representative biopsy is critical and repeat biopsy is warranted before going for definitive management.
authors.affiliation: Department of Orthopaedic Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Ramesh K
authors.initials: RK
authors.lastname: Sen
authors.forename: Lokesh A
authors.initials: LA
authors.lastname: Veerappa
authors.forename: Rakesh K
authors.initials: RK
authors.lastname: Vasishta
authors.forename: Vivek
authors.initials: V
authors.lastname: Gupta
mesh_terms: D000293:Adolescent; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D018483:Diaphyses; D005260:Female; D005266:Femoral Neoplasms / Q000175:diagnosis* / Q000473:pathology; D005598:Fractures, Spontaneous / Q000175:diagnosis*; D006801:Humans; D012516:Osteosarcoma / Q000175:diagnosis* / Q000473:pathology; D012598:Sclerosis