title: Comparison of embryological and clinical outcome in GnRH antagonist vs. GnRH agonist protocols for in vitro fertilization in PCOS non-obese patients. A prospective randomized study.
abstract: OBJECTIVE
  Embryological and clinical efficacy of gonadotropin-releasing hormone (GnRH) antagonist and agonist stimulation protocols in non-obese women with polycystic ovarian syndrome (PCOS) were compared.
  
  
  METHODS
  A prospective randomized study.
  
  
  METHODS
  Medical University Hospital.
  
  
  METHODS
  70 infertile PCOS patients; 33 in GnRH antagonist and 37 in GnRH agonist group.
  
  
  RESULTS
  Similar mature metaphase II oocyte rate (76% vs. 76%) was observed in both protocols. Optimal pronuclear morphology zygotes dominated in both groups (64% vs. 66%). Transferred embryo quality did not differ in both protocols. No significant differences between both protocols were found in delivery rate (p = 0.481), pregnancy rate (p = 0.810), multiple pregnancy rate (p = 0.501), miscarriage rate (p = 0.154), fertilization rate (p = 0.388) and implantation rate (p = 1.000). Duration of stimulation and total follicle-stimulating hormone (FSH) dose were significantly lower in GnRH antagonist protocol (p = 0.0005).
  
  
  CONCLUSIONS
  GnRH antagonist and agonist protocols in non-obese PCOS patients yield similar embryological and clinical outcomes. Shorter duration of treatment and lower FSH requirement in GnRH antagonist group may be financially beneficial and therefore attractive for patients.
authors.affiliation: Department of Reproductive Medicine and Gynecology, Pomeranian Medical University, Szczecin-Police, Poland.
authors.forename: Rafal
authors.initials: R
authors.lastname: Kurzawa
authors.forename: Przemyslaw
authors.initials: P
authors.lastname: Ciepiela
authors.forename: Tomasz
authors.initials: T
authors.lastname: Baczkowski
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Safranow
authors.forename: Pawel
authors.initials: P
authors.lastname: Brelik
mesh_terms: D000022:Abortion, Spontaneous; D000328:Adult; D005260:Female; D005306:Fertilization; D005307:Fertilization in Vitro / Q000379:methods*; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists* / Q000037:antagonists & inhibitors* / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009765:Obesity / Q000150:complications; D009865:Oocytes / Q000166:cytology; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy*; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D013094:Spermatozoa / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D007987:Gonadotropin-Releasing Hormone