[Changes of color pattern reversal visual evoked potential of primary glaucoma].
OBJECTIVE
To investigate the changes of color pattern reversal visual evoked potential (CPR-VEP)of primary glaucoma using different temporal frequencies, and to search for the best temporal frequency parameters and color parameters.


METHODS
Vision Monitor visual electrophysiograph (Métrovision, France) was used to record CPR-VEP at different temporal frequencies (1, 2, 4, 8, 16, and 32 Hz) and different color stimulations (black/white, red/green, blue/yellow) in 41 cases (70 eyes) with primary glaucoma (glaucoma group) and 13 normal subjects (26 eyes) (normal control group). P100 wave amplitudes were compared.


RESULTS
(1) In the normal control group, P100 amplitudes declined while the temporal frequency of black/white stimulation was increasing, but they had peaks at 2 Hz and 8 Hz red/green stimulation and blue/yellow stimulation. (2) In the glaucoma group, CPR-VEP P100 declined while temporal frequency was increasing under 3 color stimulations, but had a peak at 8 Hz. At 2 Hz-16 Hz, P100 amplitudes were related with the mean defect of Humphrey visual field, especially with all 3 color stimulations at 8 Hz and with blue/yellow stimulation at 2 Hz and 16 Hz. (3) P100 amplitude was most different under the 3 color stimulations between the 2 groups at 8 Hz.


CONCLUSIONS
The changes of CPR-VEP P(100) amplitude can objectively reflect the glaucoma visual function damage. CPR-VEP P100 amplitude has certain value in studying glaucoma under different color stimulations (black/white, red/green, blue/yellow) at 8 Hz, and blue/yellow stimulation at 2 Hz and 16 Hz.
Wang
Ping-Bao
PB
Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha 410008, China. pingbao-wang@hotmail.com
Tong
Yang
Y
Xia
Zhao-Hua
ZH
Tan
Qian
Q
Xia
Xiao-Bo
XB
D000328:Adult; D000368:Aged; D003118:Color Perception / Q000502:physiology*; D003119:Color Perception Tests / Q000379:methods*; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D005901:Glaucoma / Q000175:diagnosis* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged