title: Fast, acid-free, and selective lactamization of lactones in ionic liquids.
abstract: A fast and acid-free one-pot 0.2-30 mmol microwave methodology for direct ionic liquid-mediated preparation of lactams from lactones and primary amines has been developed. The protocol was investigated with a wide range of primary amines and a handful of lactones, including substrates with acid-sensitive substituents. Both gamma-lactams and delta-lactams were, despite the complete absence of a Brønsted acid, obtained in useful to excellent yields after only 35 min of microwave processing.
authors.affiliation: Organic Pharmaceutical Chemistry, Department of Medicinal Chemistry, Uppsala Biomedical Center, Uppsala University, P.O. Box 574, SE-751 23 Uppsala, Sweden.
authors.forename: Kristina M
authors.initials: KM
authors.lastname: Orrling
authors.forename: Xiongyu
authors.initials: X
authors.lastname: Wu
authors.forename: Francesco
authors.initials: F
authors.lastname: Russo
authors.forename: Mats
authors.initials: M
authors.lastname: Larhed
mesh_terms: D052578:Ionic Liquids; D007769:Lactams / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry*; D008722:Methods; D008872:Microwaves
chemical_list: D052578:Ionic Liquids; D007769:Lactams; D007783:Lactones