Anti-phospholipid antibodies in cerebrospinal fluid but not serum from a boy with psychosis.
A 12-year-old African American boy with mental retardation and Asperger's disorder presented with acute psychosis. Antiphospholipid antibody testing with enzyme-linked immunosorbent assay showed increased levels of immunoglobulin G anticardiolipin antibodies in the cerebrospinal fluid, but not in the serum. Although antiphospholipid antibodies have been reported in the serum of patients with thrombotic and neurologic disorders, there are only a few reports of these antibodies in cerebrospinal fluid. This finding is consistent with a recent report of antiphospholipid antibodies found in the cerebrospinal fluid of adults with acute psychosis.
Sokol
Deborah K
DK
Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. dksokol@iupui.edu
Chen
Lan S
LS
Wagenknecht
Dawn R
DR
McIntyre
John A
JA
D017152:Antibodies, Antiphospholipid / Q000134:cerebrospinal fluid* / Q000276:immunology; D020817:Asperger Syndrome / Q000134:cerebrospinal fluid / Q000276:immunology; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid* / Q000276:immunology; D008607:Intellectual Disability / Q000134:cerebrospinal fluid / Q000276:immunology; D008297:Male; D011618:Psychotic Disorders / Q000134:cerebrospinal fluid* / Q000276:immunology
D017152:Antibodies, Antiphospholipid; D007074:Immunoglobulin G