Mapping the BDA20 gene to BTAX.
The lipocalin family is a large group of proteins that exhibits great structural and functional variation both within and among species, including a significant number of animal-derived aeroallergens, such as the bovine BDA20 (major cow dander allergen). This protein is classified as an occupational allergen causing asthma and other work-related allergic disorders among dairy farmers. Using a somatic cell panel the BDA20 gene was assigned to the bovine X chromosome (BTAX) with a significant concordant value of 97% to the previously mapped reference marker MAF45. A radiation hybrid (RH) mapping approach confirmed the assignment of BDA20 to BTAX. Two-point LOD scores showed that BDA20 is linked to XBM451 with a LOD score of 22.1 for a theta value of 0.03.
Stafuzza
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NB
Kata
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Womack
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JE
Amaral
M E J
MEJ
D000485:Allergens / Q000235:genetics*; D000818:Animals; D052179:Antigens, Plant; D001483:Base Sequence; D002417:Cattle; D017931:DNA Primers; D006822:Hybrid Cells / Q000528:radiation effects; D008126:Lod Score; D016133:Polymerase Chain Reaction; D011506:Proteins / Q000235:genetics*; D014960:X Chromosome
D000485:Allergens; D052179:Antigens, Plant; C099745:BDA20 dander protein, Bos taurus; D017931:DNA Primers; D011506:Proteins