title: Naturally acquired humoral and cellular immune responses to Plasmodium vivax merozoite surface protein 9 in Northwestern Amazon individuals.
abstract: Antibody and T-cell reactivities to Plasmodium vivax merozoite surface protein 9 (PvMSP9) were evaluated in a cross-sectional study of individuals naturally exposed to malaria infections living in Ribeirinha, a native riverine community and in Colina, a transmigrant community, Rondonia, Brazil. The antibody responses to PvMSP9-RIRIIand PvMSP9-Nt domains in Ribeirinha were higher compared with Colina and correlated with age and time of malaria exposure. IgG2 was most prevalent for PvMSP9-RII in both communities, and IgG1 was the predominant isotype for PvMSP9-Nt and PvMSP9-RIRII in Ribeirinha. IFN-gamma and IL-4 predominated in Ribeirinha, while IFN-gamma predominated in Colina. Variation in exposure to P. vivax likely accounts for the differences observed in cytokine and antibody levels between the two populations studied.
authors.affiliation: Laboratory of Malaria Research, Institute Oswaldo Cruz, Fiocruz, Pavilhao Leonidas Deane, 5th floor, Av. Brasil 4365 - ZIP: 21045-900, Rio de Janeiro, Brazil.
authors.forename: J C
authors.initials: JC
authors.lastname: Lima-Junior
authors.forename: T M
authors.initials: TM
authors.lastname: Tran
authors.forename: E V S
authors.initials: EV
authors.lastname: Meyer
authors.forename: B
authors.initials: B
authors.lastname: Singh
authors.forename: S G
authors.initials: SG
authors.lastname: De-Simone
authors.forename: F
authors.initials: F
authors.lastname: Santos
authors.forename: C T
authors.initials: CT
authors.lastname: Daniel-Ribeiro
authors.forename: A
authors.initials: A
authors.lastname: Moreno
authors.forename: J W
authors.initials: JW
authors.lastname: Barnwell
authors.forename: M R
authors.initials: MR
authors.lastname: Galinski
authors.forename: J
authors.initials: J
authors.lastname: Oliveira-Ferreira
mesh_terms: D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood / Q000276:immunology*; D000917:Antibody Formation / Q000276:immunology; D001938:Brazil / Q000453:epidemiology; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D018984:Epitopes, T-Lymphocyte / Q000276:immunology; D005260:Female; D006801:Humans; D007110:Immunity, Active; D007111:Immunity, Cellular; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007371:Interferon-gamma / Q000097:blood / Q000276:immunology; D015847:Interleukin-4 / Q000097:blood / Q000276:immunology; D016780:Malaria, Vivax / Q000453:epidemiology / Q000276:immunology*; D008297:Male; D008565:Membrane Proteins / Q000276:immunology*; D008875:Middle Aged; D010966:Plasmodium vivax / Q000276:immunology*; D015995:Prevalence; D015800:Protozoan Proteins / Q000276:immunology*; D011994:Recombinant Proteins / Q000276:immunology; D055815:Young Adult
chemical_list: D000913:Antibodies, Protozoan; D018984:Epitopes, T-Lymphocyte; D007074:Immunoglobulin G; D008565:Membrane Proteins; D015800:Protozoan Proteins; D011994:Recombinant Proteins; C455300:merozoite surface protein 9, Plasmodium; D015847:Interleukin-4; D007371:Interferon-gamma