[Drug induced diarrhea].
Diarrhea is a frequent adverse event involving the most frequently antibiotics, laxatives and NSAI. Drug induced diarrhea may be acute or chronic. It may be due to expected, dose dependant properties of the drug, to immuno-allergic or bio-genomic mechanisms. Several pathophysiological mechanisms have been described resulting in osmotic, secretory or inflammatory diarrhea, shortened transit time, or malabsorption. Histopathological lesions sometimes associated with drug induced diarrhea are usually non specific and include ulcerations, inflammatory or ischemic lesions, fibrous diaphragms, microscopic colitis and apoptosis. The diagnosis of drug induced diarrhea, sometimes difficult to assess, relies on the absence of other obvious causes and on the rapid disappearance of the symptoms after withdrawal of the suspected drug.
Morard
Isabelle
I
Service de gastroentérologie et d'hépatologie, HUG, 1211 Geneve 14. isabelle.morard@hcuge.ch
Hadengue
Antoine
A
D000900:Anti-Bacterial Agents / Q000009:adverse effects; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D017091:Colitis, Ischemic / Q000139:chemically induced / Q000473:pathology; D046728:Colitis, Microscopic / Q000139:chemically induced / Q000473:pathology; D003106:Colon / Q000473:pathology; D003967:Diarrhea / Q000139:chemically induced* / Q000145:classification / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D064420:Drug-Related Side Effects and Adverse Reactions; D005243:Feces / Q000737:chemistry; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D007421:Intestine, Small / Q000473:pathology; D008286:Malabsorption Syndromes / Q000150:complications
D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal