title: Real-time MRI-TRUS fusion for guidance of targeted prostate biopsies.
abstract: Targeted prostate biopsy is challenging because no currently established imaging modality is both accurate for prostate cancer diagnosis and cost-effective for real-time procedure guidance. A system that fuses real-time transrectal ultrasound images with previously acquired endorectal coil MRI images for prostate biopsy guidance is presented here. The system uses electromagnetic tracking and intraoperative image registration to superimpose the MRI data on the ultrasound image. Prostate motion is tracked and compensated for without the need for fiducial markers. The accuracy of the system in phantom studies was shown to be 2.4 +/- 1.2 mm. The fusion system has been used in more than 20 patients to guide biopsies with almost no modification of the conventional protocol. Retrospective clinical evaluation suggests that clinically acceptable spatial accuracy can be achieved.
authors.affiliation: Philips Research North America, Briarcliff, New York, USA. sheng.xu@philips.com
authors.forename: Sheng
authors.initials: S
authors.lastname: Xu
authors.forename: Jochen
authors.initials: J
authors.lastname: Kruecker
authors.forename: Baris
authors.initials: B
authors.lastname: Turkbey
authors.forename: Neil
authors.initials: N
authors.lastname: Glossop
authors.forename: Anurag K
authors.initials: AK
authors.lastname: Singh
authors.forename: Peter
authors.initials: P
authors.lastname: Choyke
authors.forename: Peter
authors.initials: P
authors.lastname: Pinto
authors.forename: Bradford J
authors.initials: BJ
authors.lastname: Wood
mesh_terms: D001707:Biopsy, Needle / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods; D008297:Male; D010865:Pilot Projects; D011467:Prostate / Q000000981:diagnostic imaging / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D013997:Time Factors; D014463:Ultrasonography