title: Clinical outcomes of sirolimus with eluting stent implantation in coronary artery disease.
abstract: OBJECTIVE
  To evaluate the immediate post procedure, thirty-days, and six-months clinical outcomes of sirolimus-eluting stents (SES) implantation in patients with single and multivessel coronary artery disease (CAD).
  
  
  METHODS
  A case series of all consecutive patients undergoing percutaneous coronary interventions (PCI) with SES implantation at Shifa International Hospital, Islamabad, were evaluated at early post-procedure, 30-days and six-months clinical follow-up for the incidence of major adverse cardiac event (MACE). This included death, nonfatal myocardial infarction (MI) and repeat revascularization.
  
  
  RESULTS
  Out of 206 consecutive patients, 324 had SES implanted. Cumulative MACE rate was 2.93% and 6% at 30-days and six-months follow-ups respectively. Five patients developed ST-segment elevation MI (STEMI). One patient developed non-STEMI. Emergency Coronary Artery Bypass Grafting (CABG) was done in two patients. Repeat (PCI) was carried in three (1.46%) patients for acute in-stent thrombosis. Diabetes Mellitus and multivessel stenting were found to be the independent predictors for acute in-stent thrombosis (P-value < 0.02 and 0.05 respectively).
  
  
  CONCLUSIONS
  SES implantation in coronary artery disease can be safe and effective MACE at one and six months follow-ups.
authors.affiliation: The Aga Khan University Hospital, Karachi, Pakistan.
authors.forename: Munsif
authors.initials: M
authors.lastname: Ali
authors.forename: Syed Mumtaz Ali
authors.initials: SM
authors.lastname: Shah
authors.forename: Zaman
authors.initials: Z
authors.lastname: Shah
authors.forename: Islam
authors.initials: I
authors.lastname: Hussain
authors.forename: Khezar Shahzada
authors.initials: KS
authors.lastname: Syed
authors.forename: Hadi Mohammad
authors.initials: HM
authors.lastname: Khan
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D003324:Coronary Artery Disease / Q000188:drug therapy* / Q000601:surgery / Q000628:therapy; D023903:Coronary Restenosis / Q000517:prevention & control; D054855:Drug-Eluting Stents; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D020123:Sirolimus / Q000627:therapeutic use*; D017211:Treatment Failure; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D020123:Sirolimus