title: A hypercaloric pellet-diet cycle induces obesity and co-morbidities in Wistar rats.
abstract: The present study was carried to develop and analyze the consequences of hypercaloric pellet-diet cycle that promotes obesity in rats. Male Wistar rats were randomly distributed into two groups that received either normal diet (ND; n =32; 3,5 Kcal/g) or a hypercaloric diet (HD; n =32; 4,6 Kcal/g). The ND group received commercial Labina rat feeding while the HD animals received a cycle of five hypercaloric diets over a 14-week period. The effects of the diets were analyzed in terms of body weight, body composition, hormone-metabolite levels, systolic arterial pressure and glucose tolerance at the 5% significance level. The hypercaloric pellet diet cycle promoted an increase in body weight and fat, systolic arterial pressure and a high serum level of glucose, triacylglycerol, insulin and leptin. The HD group also presented an impaired glucose tolerance. In conclusion, the results of this study show that the hypercaloric pellet-diet cycle promoted obesity in Wistar rats and displayed several characteristics that are commonly associated with human obesity, such as high arterial pressure, insulin resistance, hyperglycaemia, hyperinsulinaemia, hyperleptinaemia and dyslipidaemia.
authors.affiliation: Departamento de Clínica Médica e Laboratório Experimental da Clínica Médica da Faculdade de Medicina de Botucatu, Universidade Estadual Paulista.
authors.forename: André F
authors.initials: AF
authors.lastname: Nascimento
authors.forename: Mário M
authors.initials: MM
authors.lastname: Sugizaki
authors.forename: André S
authors.initials: AS
authors.lastname: Leopoldo
authors.forename: Ana P
authors.initials: AP
authors.lastname: Lima-Leopoldo
authors.forename: Renata A M
authors.initials: RA
authors.lastname: Luvizotto
authors.forename: Célia R
authors.initials: CR
authors.lastname: Nogueira
authors.forename: Antonio C
authors.initials: AC
authors.lastname: Cicogna
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001794:Blood Pressure; D001823:Body Composition; D001835:Body Weight; D004041:Dietary Fats / Q000008:administration & dosage / Q000009:adverse effects*; D004195:Disease Models, Animal; D050171:Dyslipidemias / Q000209:etiology*; D002149:Energy Intake; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology*; D006946:Hyperinsulinism / Q000209:etiology*; D006973:Hypertension / Q000209:etiology*; D020738:Leptin / Q000097:blood; D008297:Male; D009765:Obesity / Q000209:etiology* / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004041:Dietary Fats; D020738:Leptin