Steroidal glycosides from the underground parts of Trillium erectum and their cytotoxic activity.
Six steroidal glycosides, along with 14 known compounds, were isolated from the underground parts of Trillium erectum L. (Liliaceae). The structures of 1-6 were determined on the basis of extensive spectroscopic analysis, including two-dimensional (2D) NMR data, and a few chemical transformations. The isolated compounds were evaluated for their cytotoxic activity against HL-60 human promyelocytic leukemia cells.
Yokosuka
Akihito
A
Tokyo University of Pharmacy and Life Sciences, School of Pharmacy, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan. yokosuka@ps.toyaku.ac.jp
Mimaki
Yoshihiro
Y
D000818:Animals; D002417:Cattle; D016923:Cell Death / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry* / Q000633:toxicity*; D018922:HL-60 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D018514:Plant Structures / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry* / Q000633:toxicity*; D031446:Trillium / Q000737:chemistry*
D006027:Glycosides; D013256:Steroids