Temporal alterations in concentrations of sera cytokines/chemokines in sepsis due to group B streptococcus infection in a neonate.
Group B streptococcus (GBS) is the most common pathogen in neonates and may induce the overproduction of cytokines. To further clarify temporal alterations in the levels of various cytokines/chemokines, we measured the concentrations of 16 types of these immunological responders in the serum of a neonate presenting with GBS infection. At birth, the concentrations of different cytokines/chemokines increased and that of granulocyte colony-stimulating factor remained high. Thus, these cytokines/chemokines might be associated with the pathophysiology of GBS infection.
Okazaki
Kaoru
K
Divisions of Neonatology, Tokyo Metropolitan Hachioji Children's Hospital, Tokyo 193-0931, Japan. okazaki@chp.hachioji.tokyo.jp
Kondo
Masatoshi
M
Kato
Masahiko
M
Nishida
Akira
A
Takahashi
Hidehiro
H
Noda
Masahiro
M
Kimura
Hirokazu
H
D016207:Cytokines / Q000096:biosynthesis / Q000097:blood*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000097:blood; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D018805:Sepsis / Q000276:immunology* / Q000382:microbiology*; D013290:Streptococcal Infections / Q000276:immunology* / Q000382:microbiology / Q000503:physiopathology*; D013292:Streptococcus agalactiae; D015854:Up-Regulation
D016207:Cytokines; D016178:Granulocyte-Macrophage Colony-Stimulating Factor