Ni(II), Cu(II), and Zn(II) diethyldithiocarbamate complexes show various activities against the proteasome in breast cancer cells.
A series of three complexes with diethyldithiocarbamate ligand and three different metals (Ni, Cu, Zn) was prepared, confirmed by X-ray crystallography, and tested in human breast cancer MDA-MB-231 cells. Zinc and copper complexes, but not nickel complex, were found to be more active against cellular 26S proteasome than against purified 20S proteasome core particle. One of the possible explanations is inhibition of JAMM domain in the 19S proteasome lid.
Cvek
Boris
B
Department of Medical Chemistry and Biochemistry, Department of Cell Biology and Genetics, Palacky University, Olomouc 77515, Czech Republic.
Milacic
Vesna
V
Taraba
Jan
J
Dou
Q Ping
QP
D001943:Breast Neoplasms / Q000201:enzymology* / Q000473:pathology; D045744:Cell Line, Tumor; D003300:Copper; D004050:Ditiocarb / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D009532:Nickel; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D061988:Proteasome Inhibitors; D015032:Zinc
D004791:Enzyme Inhibitors; D009942:Organometallic Compounds; D061988:Proteasome Inhibitors; C067982:bis(N,N-diethyldithiocarbamate)Cu (II) complex; D003300:Copper; D009532:Nickel; D004050:Ditiocarb; D046988:Proteasome Endopeptidase Complex; D015032:Zinc