Active metabolites from Dunalia spinosa resinous exudates.
Dunalia spinosa, a plant used in folk medicine for toothaches, breathing problems and cleansing wounds, was found active as antimicrobial and antioxidant. A new (E)-aurone rutinoside (dunaurone) has been isolated from the aerial parts of the plant, and its structure was determined by spectroscopic means. Lupeol, beta-sitosterol, scopoletin, quercetin and withaferin A were also found. All the extracts exhibited strong antimicrobial activity while dunaurone showed only weak antimicrobial inhibition against Klebsiella pneumoniae; in addition it presented a significant free radical scavenging activity.
Erazo
Silvia
S
Department of Pharmacological and Toxicological Chemistry, School of Chemical and Pharmaceutical Sciences, University of Chile, P. O. Box 233, Santiago 1, Chile. serazo@uchile.cl
Rocco
Giovanna
G
Zaldivar
Mercedes
M
Delporte
Carla
C
Backhouse
Nadine
N
Castro
Consuelo
C
Belmonte
Eliana
E
Delle Monache
Franco
F
García
Rubén
R
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D019657:Solanaceae / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013481:Superoxides / Q000378:metabolism; D014969:Xanthine Oxidase / Q000378:metabolism
D000900:Anti-Bacterial Agents; D010936:Plant Extracts; D013481:Superoxides; D014969:Xanthine Oxidase