Highly enantioselective copper-catalyzed ring opening of oxabicyclic alkenes with Grignard reagents.
A highly efficient copper-catalyzed enantioselective ring opening of oxabicylic alkenes with Grignard reagents has been developed by using chiral spiro phosphine ligands. Excellent trans selectivities, good yields, and high enantioselectivities are obtained for a broad range of Grignard reagents under mild reaction conditions. The catalyst system shows an extraordinary activity and the TON of the reaction reaches 9000.
Zhang
Wei
W
State Key Laboratory and Institute of Elemento-Organic Chemistry Nankai University, Tianjin (China).
Zhu
Shou-Fei
SF
Qiao
Xiang-Chen
XC
Zhou
Qi-Lin
QL