Anti-biofouling properties of polymers with a carboxybetaine moiety.
The resistance of random copolymers of BMA and CMB against biofouling was evaluated. The amount of proteins adsorbed onto the CMB copolymers was smaller than that onto other polymers (non-ionic polymers and copolymers of ordinary ionic monomers and BMA) and decreased with an increase in the content of CMB residues. Furthermore, there was a dramatic decrease in the number of cells (platelets and fibroblasts) that adhered to the CMB copolymers compared with that to other polymers. In contrast with this, CMB copolymers were slightly perturbative to both complement and coagulation systems. However, the overall results suggest that zwitterionic moieties are effective for making polymer materials biocompatible due to their excellent anti-biofouling property.
Tada
Susumu
S
Department of Environmental Applied Chemistry, Graduate School of Science and Engineering, University of Toyama, Toyama 930-8555, Japan.
Inaba
Chika
C
Mizukami
Kazuya
K
Fujishita
Shigeto
S
Gemmei-Ide
Makoto
M
Kitano
Hiromi
H
Mochizuki
Akira
A
Tanaka
Masaru
M
Matsunaga
Takayuki
T
D000327:Adsorption; D000818:Animals; D001622:Betaine / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D001792:Blood Platelets / Q000378:metabolism; D002417:Cattle; D002448:Cell Adhesion / Q000502:physiology*; D003167:Complement Activation; D005347:Fibroblasts / Q000378:metabolism; D008422:Materials Testing; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry*; D013499:Surface Properties
D001672:Biocompatible Materials; D011108:Polymers; D001622:Betaine