In tube determination of the absolute configuration of alpha- and beta-hydroxy acids by NMR via chiral BINOL borates.
A simple NMR methodology, through the formation of chiral BINOL borates in the NMR tube, and that reunites the advantages of chiral derivatizing (CDAs) and chiral solvating agents (CSAs), is presented for the assignment of the absolute configuration of alpha- and beta-hydroxy acids.
Freire
Félix
F
Departamento de Química Orgánica, Universidad de Santiago de Compostela, E-15782, Santiago de Compostela, Spain.
Quiñoá
Emilio
E
Riguera
Ricardo
R
D000143:Acids / Q000737:chemistry*; D001881:Borates / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D015394:Molecular Structure; D009284:Naphthols / Q000737:chemistry*; D013237:Stereoisomerism
D000143:Acids; C406944:BINOL, naphthol; D001881:Borates; D009284:Naphthols