title: Locally relapsed and metastatic uterine leiomyoma: a case report.
abstract: BACKGROUND
  Benign metastasising leiomyoma refers to a type of lesion characterised by leiomyomatous alterations without any indication of malignancy. It presents as either a singular nodule or multiple nodules of proliferating smooth muscle cells and is generally found in the lungs of women who have undergone a hysterectomy. The purpose of this case report is to contribute to the knowledge of this rare disease by presenting evidence and experience of a patient case. In particular, this report seeks to investigate the therapeutic approaches in order to understand whether a standard of care can be prescribed and whether the use of prophylaxis therapy with progesterone as a follow-up to surgery serves as a reasonable treatment in certain cases diagnosed as benign metastasising leiomyoma.
  
  
  METHODS
  We present the case of a 52-year-old Caucasian woman who developed a pelvic relapse and a pulmonary localisation of benign metastasising leiomyoma following a hysterectomy for myomatous uterus.
  
  
  CONCLUSIONS
  Our literature review revealed a single case of the use of chemoprophylaxis as treatment of a benign metastasising leiomyoma. The role of chemoprophylaxis in preventing future recurrences remains unclear. The use of progesterone as an adjuvant therapy for benign metastasising leiomyoma could simply be palliative, with associated psychological benefits, or it could be of therapeutic significance.
authors.affiliation: Clinica di Ginecologia ed Ostetricia, University of Udine, piazzale SM della Misericordia, Udine, Italy. ambrogio.londero@gmail.com
authors.forename: Ambrogio P
authors.initials: AP
authors.lastname: Londero
authors.forename: Patrizia
authors.initials: P
authors.lastname: Perego
authors.forename: Costantino
authors.initials: C
authors.lastname: Mangioni
authors.forename: Ralph J
authors.initials: RJ
authors.lastname: Lellé
authors.forename: Franco
authors.initials: F
authors.lastname: Londero
authors.forename: Diego
authors.initials: D
authors.lastname: Marchesoni