Alkaloids from the roots of Zanthoxylum nitidum and their antiviral and antifungal effects.
Five alkaloids, 5,6-dihydro-6-methoxynitidine (1), dictamnine (2), gamma-fagarine (3), skimmianine (4), and 5-methoxydictamnine (5), were isolated from the roots of Zanthoxylum nitidum. Their structures and configurations were elucidated by spectroscopic methods and X-ray analysis. Compounds 1, 4, and 5 showed in vitro antiviral effect against hepatitis B virus, and compounds 2, 3, and 5 demonstrated marked antimitotic and antifungal activity.
Yang
Guohong
G
Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 200032, P. R. China.
Chen
Daofeng
D
D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D001203:Ascomycota / Q000187:drug effects; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D006515:Hepatitis B virus / Q000187:drug effects; D006801:Humans; D008938:Mitosis / Q000187:drug effects; D008958:Models, Molecular; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D032106:Zanthoxylum / Q000737:chemistry*
D000470:Alkaloids; D000935:Antifungal Agents; D000998:Antiviral Agents