SERRS immunoassay for quantitative human CRP analysis.
SERRS has been used for the first time for the measurement of C-reactive protein (CRP) in an immunoassay. CRP, a biological marker for the diagnosis of infection and inflammation, is quantified in an ELISA using conventional reagents, but the usual colorimetric detection step is replaced by SERRS detection, offering improved sensitivity and potential for multiplexing analysis.
Campbell
Fiona M
FM
Division of Animal Production & Public Health, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, UK.
Ingram
Andrew
A
Monaghan
Paul
P
Cooper
Jon
J
Sattar
Naveed
N
Eckersall
P David
PD
Graham
Duncan
D
D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D004396:Coloring Agents; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D006046:Gold; D006801:Humans; D053758:Nanoparticles; D012680:Sensitivity and Specificity; D013059:Spectrum Analysis, Raman / Q000379:methods
D015415:Biomarkers; D004396:Coloring Agents; D006046:Gold; D002097:C-Reactive Protein