title: Analytical applications of second-order calibration methods.
abstract: Second-order calibration methods are gaining widespread acceptance among the analytical community mainly because: (1) a wide range of analytical instrumentation is available that enables high dimensionality data to be obtained; (2) the chemometric techniques for treating these data are highly developed; and (3) they have the so-called "second-order advantage", i.e. they can predict the concentration of the analyte of interest even in the presence of unknown interferents. This also enables several analytes to be determined simultaneously. In this paper we describe the most common instrumental and chemometric techniques used in second-order calibration and discuss their applications since 2000. First, we introduce briefly the techniques and then we comment the applications. Given the practical nature of this paper, we have classified the techniques according to five fields of application: pharmaceuticals, biological matrices, foods, environmental matrices and synthetic matrices.
authors.affiliation: Chemometrics, Qualimetrics and Nanonsensors Research Group, Analytical Chemistry and Organic Chemistry Department, Rovira i Virgili University, Marcel lí Domingo, Campus Sescelades, 43007 Tarragona, Spain.
authors.forename: Verónica
authors.initials: V
authors.lastname: Gómez
authors.forename: María Pilar
authors.initials: MP
authors.lastname: Callao