title: Comparison of a potentiometric and a micromechanical triglyceride biosensor.
abstract: Sensitive biosensors for detection of triglyceride concentration are important. In this paper we report on two types of silicon based triglyceride sensors: an electrolyte-insulator-semiconductor capacitor (EISCAP) which is a potentiometric device and a polysilicon microcantilever. The detection principle for both sensors is based on the enzymatic hydrolysis of triglyceride though the sensing mechanisms are different: electronic for the EISCAP and mechanical for the microcantilever. The characteristics and performances of the two sensors are critically compared. The EISCAP sensor necessitates the presence of a buffer for stable measurements which limits the sensitivity of the sensor at low concentrations of the bioanalyte to 1mM. The cantilever sensor works without a buffer which improves the lower level of sensitivity to 10 microm. Both sensors are found to give reproducible and reliable results.
authors.affiliation: Department of Electrical Engineering, Indian Institute of Technology Madras, Chennai 600036, India.
authors.forename: Renny Edwin
authors.initials: RE
authors.lastname: Fernandez
authors.forename: Vemulachedu
authors.initials: V
authors.lastname: Hareesh
authors.forename: Enakshi
authors.initials: E
authors.lastname: Bhattacharya
authors.forename: Anju
authors.initials: A
authors.lastname: Chadha
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D004563:Electrochemistry / Q000295:instrumentation*; D004566:Electrodes; D004867:Equipment Design; D019544:Equipment Failure Analysis; D055617:Micro-Electrical-Mechanical Systems / Q000295:instrumentation*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014280:Triglycerides / Q000032:analysis*
chemical_list: D014280:Triglycerides