title: Serum levels of P-selectin in men with high-functioning autism.
abstract: Immune dysfunction has been proposed as a mechanism for the pathophysiology of autistic-spectrum disorders. The selectin family of adhesion molecules plays a prominent role in immune/inflammatory responses. We determined the serum levels of three types of soluble-form selectin (sP, sL and sE) in 15 men with high-functioning autism and 22 age-matched healthy controls by enzyme-linked immunosorbent assay. Levels of sP-selectin and sL-selectin were significantly lower in patients than in controls. Furthermore, sP-selectin levels were negatively correlated with impaired social development during early childhood.
authors.affiliation: Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Iwata
authors.forename: K J
authors.initials: KJ
authors.lastname: Tsuchiya
authors.forename: S
authors.initials: S
authors.lastname: Mikawa
authors.forename: K
authors.initials: K
authors.lastname: Nakamura
authors.forename: Y
authors.initials: Y
authors.lastname: Takai
authors.forename: S
authors.initials: S
authors.lastname: Suda
authors.forename: Y
authors.initials: Y
authors.lastname: Sekine
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Kawai
authors.forename: G
authors.initials: G
authors.lastname: Sugihara
authors.forename: H
authors.initials: H
authors.lastname: Matsuzaki
authors.forename: K
authors.initials: K
authors.lastname: Hashimoto
authors.forename: M
authors.initials: M
authors.lastname: Tsujii
authors.forename: T
authors.initials: T
authors.lastname: Sugiyama
authors.forename: N
authors.initials: N
authors.lastname: Takei
authors.forename: N
authors.initials: N
authors.lastname: Mori
mesh_terms: D001321:Autistic Disorder / Q000097:blood*; D016022:Case-Control Studies; D019040:E-Selectin / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D019041:L-Selectin / Q000097:blood; D008297:Male; D019007:P-Selectin / Q000097:blood*; D055815:Young Adult
chemical_list: D019040:E-Selectin; D019007:P-Selectin; D019041:L-Selectin