Blood ghrelin, resistin, and adiponectin concentrations during the normal menstrual cycle.
OBJECTIVE
To investigate changes of ghrelin, resistin, and adiponectin levels in the circulation during the normal menstrual cycle.


METHODS
Longitudinal study.


METHODS
The study was conducted at a university hospital.


METHODS
Eight healthy normally cycling women.


METHODS
The women were observed during a whole menstrual cycle. Daily blood samples were taken every morning, after overnight fasting, from day 2 of the cycle until the next menstrual period.


METHODS
Plasma acylated and unacylated ghrelin and serum resistin, adiponectin, FSH, LH, E(2), and P levels were measured in all blood samples.


RESULTS
In all women serum FSH, LH, E(2), and P levels, normalized to the midcycle peak LH value, showed the typical changes of the normal menstrual cycle. Acylated and unacylated ghrelin, resistin, and adiponectin levels did not change significantly during the whole menstrual cycle.


CONCLUSIONS
The present study shows for the first time that plasma ghrelin and serum resistin levels do not change significantly during the normal menstrual cycle. It is also confirmed that serum adiponectin levels remain stable throughout the cycle. It is suggested that ovarian steroid dynamics during the cycle have no effect on the secretion of these substances.
Dafopoulos
Konstantinos
K
Department of Obstetrics and Gynecology, University of Thessalia, Larissa, Greece.
Sourlas
Dimitrios
D
Department of Obstetrics and Gynecology, University of Thessalia, Larissa, Greece.
Kallitsaris
Athanasios
A
Department of Obstetrics and Gynecology, University of Thessalia, Larissa, Greece.
Pournaras
Spyros
S
Department of Microbiology, University of Thessalia, Larissa, Greece.
Messinis
Ioannis E
IE
Department of Obstetrics and Gynecology, University of Thessalia, Larissa, Greece. Electronic address: messinis@med.uth.gr.
D052242:Adiponectin / Q000097:blood; D000328:Adult; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D008137:Longitudinal Studies; D007986:Luteinizing Hormone / Q000097:blood; D008597:Menstrual Cycle / Q000097:blood*; D009994:Osmolar Concentration; D011374:Progesterone / Q000097:blood; D052243:Resistin / Q000097:blood*; D055815:Young Adult
C499918:ADIPOQ protein, human; D052242:Adiponectin; D054439:Ghrelin; C499624:RETN protein, human; D052243:Resistin; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone