title: Recurrence of hepatitis-associated aplastic anemia after a 10-year interval.
abstract: Hepatitis-associated aplastic anemia (HAA) has been reported to show a successful outcome following immunosuppressive treatment. On the other hand, the long-term prognosis of HAA has not been sufficiently clarified. Herein we report a patient with HAA who had been treated with cyclosporine for one year, and maintained complete remission without treatment. Ten years later, acute non-A, non-B, and non-C hepatitis reccurred followed by bone marrow aplasia. A second immunosuppressive treatment with antithymocyte globulin and cyclosporine was effective. This case might provide useful information for the long-term follow-up of patients with HAA.
authors.affiliation: Department of Hematology, Matsuyama Red Cross Hospital. muta-t@matsuyama.jrc.or.jp
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Muta
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Eiji
authors.initials: E
authors.lastname: Takeshita
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Takahito
authors.initials: T
authors.lastname: Tokuyama
authors.forename: Yoko
authors.initials: Y
authors.lastname: Ueda
authors.forename: Koji
authors.initials: K
authors.lastname: Joko
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Fujisaki
authors.forename: Eisuke
authors.initials: E
authors.lastname: Yokota
mesh_terms: D000293:Adolescent; D000741:Anemia, Aplastic / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D016572:Cyclosporine / Q000627:therapeutic use; D006505:Hepatitis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D012008:Recurrence; D013997:Time Factors
chemical_list: D000961:Antilymphocyte Serum; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D008775:Methylprednisolone