Polymeric PARACEST agents for enhancing MRI contrast sensitivity.
Linear polymers of PARACEST agents were prepared by using classical free radical chain polymerization conditions. The Eu3+-polymers exhibited similar intermediate-to-slow water exchange and CEST characteristics as the Eu3+-monomers. This provided an avenue to lower the detection limit of these imaging agents substantially and makes them potentially useful as MRI sensors for molecular imaging.
Wu
Yunkou
Y
Department of Chemistry, University of Texas at Dallas, P.O. Box 830668, Richardson, Texas 75083, USA.
Zhou
Youfu
Y
Ouari
Olivier
O
Woods
Mark
M
Zhao
Piyu
P
Soesbe
Todd C
TC
Kiefer
Garry E
GE
Sherry
A Dean
AD
D002614:Chelating Agents / Q000138:chemical synthesis / Q000737:chemistry*; D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry*; D005063:Europium / Q000737:chemistry; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008280:Magnetics; D015394:Molecular Structure; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D012680:Sensitivity and Specificity
D002614:Chelating Agents; D003287:Contrast Media; D011108:Polymers; D005063:Europium