Cytotoxic xenicane diterpenes from the brown alga Padina pavonia (L.) Gaill.
Column chromatography of the hexane fraction of a methanol extract of Padina pavonia (L.) Gaill. collected from the Red Sea at Hurghada, Egypt yielded 18,19-epoxyxenic-19-methoxy-18-hydroxy-4-acetoxy-6,9,13-triene (1) and 18,19-epoxyxenic-18,19-dimethoxy-4-hydroxy-6,9,13-triene (2). The isolated compounds have various antitumor activities against lung carcinoma (H460) and liver carcinoma (HepG2) human cell lines (in vitro).
Awad
Nagwa E
NE
Pharmacognosy Department, National Research Center, Dokki, Cairo, Egypt. NagwaEA@hotmail.com
Selim
Mohamed A
MA
Metawe
Hemaia M
HM
Matloub
Azza A
AA
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D000459:Phaeophyceae / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*
C533962:18,19-epoxyxenic-18,19-dimethoxy-4-hydroxy-6,9,13-triene; C533961:18,19-epoxyxenic-19-methoxy-18-hydroxy-4-acetoxy-6,9,13-triene; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D010936:Plant Extracts