title: Strontium modified biocements with zero order release kinetics.
abstract: Strontium-substituted beta-TCP with the general formula Ca((3-x))Sr(x)(PO(4))(2) (0<x<1) was synthesized by calcination of powder mixtures with the appropriate stoichiometry and reacted with acidic monocalcium phosphate monohydrate (MCPM) to form a cementitious matrix of secondary calcium phosphates. The use of Sr-substituted beta-TCP as a reactant not only induced strontium substitution in the setting products but surprisingly it also favoured the formation of monetite (CaHPO(4)) as setting product, whereas Sr-free cements set to brushite (CaHPO(4).2H(2)O). Release experiments under dynamic conditions for up to 15 days revealed the release of Sr(2+) ions at dose ranges of 12-30 ppm with zero order release kinetic. Cement cytocompatibility was investigated by culturing human osteoblast cell line hFOB1.19 on cement surfaces whereas Sr-containing cements were as good as Sr-free cements in providing a template for cell growth and function.
authors.affiliation: Departamento de Química Física II, Facultad de Farmacia, UCM, 28040 Madrid, Spain.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hamdan Alkhraisat
authors.forename: Claus
authors.initials: C
authors.lastname: Moseke
authors.forename: Luis
authors.initials: L
authors.lastname: Blanco
authors.forename: Jake E
authors.initials: JE
authors.lastname: Barralet
authors.forename: Enrique
authors.initials: E
authors.lastname: Lopez-Carbacos
authors.forename: Uwe
authors.initials: U
authors.lastname: Gbureck
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D001843:Bone Cements / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D002130:Calcium Phosphates / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D002413:Cations, Divalent / Q000737:chemistry / Q000493:pharmacokinetics; D002460:Cell Line; D006801:Humans; D013324:Strontium / Q000737:chemistry / Q000493:pharmacokinetics; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements; D002130:Calcium Phosphates; D002413:Cations, Divalent; C485817:beta-tricalcium phosphate; D013324:Strontium