Diversity-oriented synthesis of novel polycyclic scaffolds using polymer-bound reagents.
A concise sequence utilizing a Petasis three component reaction followed by a tandem aza-Cope-Mannich cyclization afforded novel polycyclic heterocycles in good yield; alternative iminium cyclization based on a Pictet-Spengler reaction or aminal formation led to divergent pathways affording skeletal diversity.
García-Cuadrado
Domingo
D
Institut de Science et d'Ingénierie Supramoléculaires, Université Louis Pasteur - 67000, Strasbourg, France.
Barluenga
Sofia
S
Winssinger
Nicolas
N
D001372:Aza Compounds / Q000737:chemistry; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis; D007202:Indicators and Reagents / Q000737:chemistry*; D008352:Mannich Bases / Q000737:chemistry; D011083:Polycyclic Compounds / Q000138:chemical synthesis*; D011108:Polymers / Q000737:chemistry*
D001372:Aza Compounds; D006571:Heterocyclic Compounds; D007202:Indicators and Reagents; D008352:Mannich Bases; D011083:Polycyclic Compounds; D011108:Polymers