Combinatorial libraries of bis-heterocyclic compounds with skeletal diversity.
Combinatorial solid-phase synthesis of bis-heterocyclic compounds, characterized by the presence of two heterocyclic cores connected by a spacer of variable length/structure, provided structurally heterogeneous libraries with skeletal diversity. Both heterocyclic rings were assembled on resin in a combinatorial fashion.
Soural
Miroslav
M
Department of Chemistry and Biochemistry, 251 Nieuwland Science Center, University of Notre Dame, Notre Dame, Indiana 46556, USA.
Bouillon
Isabelle
I
Krchnák
Viktor
V
D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003432:Cross-Linking Reagents; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D054852:Small Molecule Libraries / Q000138:chemical synthesis*
D003432:Cross-Linking Reagents; D006571:Heterocyclic Compounds; D054852:Small Molecule Libraries