A prospective randomized controlled trial of preimplantation genetic screening in the "good prognosis" patient.
OBJECTIVE
To determine whether the routine use of preimplantation genetic screening (PGS) in "good prognosis" women improves in vitro fertilization (IVF) cycle outcome.


METHODS
Randomized, controlled, prospective clinical study.


METHODS
Private infertility clinic.


METHODS
Infertile women predicted to have a good prognosis as defined by: age <39 years, normal ovarian reserve, body mass index <30 kg/m(2), presence of ejaculated sperm, normal uterus, <or=2 previous failed IVF cycles.


METHODS
Patients were randomized to the PGS group or the control group on day 3 after oocyte retrieval; 23 women underwent blastomere biopsy on day 3 after fertilization (PGS group), and 24 women underwent routine IVF (control group). All embryos were transferred on day 5 or 6 after fertilization.


METHODS
Pregnancy, implantation, multiple gestation, and live birth rates.


RESULTS
No statistically significant differences were found between the PGS and control groups with respect to clinical pregnancy rate (52.4% versus 72.7%). However, the embryo implantation rate was statistically significantly lower for the PGS group (31.7% versus 62.3%) as were the live birth rate (28.6% versus 68.2%) and the multiple birth rate (9.1% versus 46.7%).


CONCLUSIONS
In a "good prognosis" population of women, PGS does not appear to improve pregnancy, implantation, or live birth rates.
Meyer
Liza R
LR
Karande and Associates, Hoffman Estates, Illinois 60194, USA.
Klipstein
Sigal
S
Hazlett
William D
WD
Nasta
Tricia
T
Mangan
Patricia
P
Karande
Vishvanath C
VC
D000328:Adult; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D011247:Pregnancy; D018873:Pregnancy Rate; D019836:Preimplantation Diagnosis; D011379:Prognosis; D011446:Prospective Studies