title: Model-based identification and diagnosis of a porcine model of induced endotoxic shock with hemofiltration.
abstract: A previously validated cardiovascular system (CVS) model and parameter identification method for cardiac and circulatory disease states are extended and further validated in a porcine model (N=6) of induced endotoxic shock with hemofiltration. Errors for the identified model are within 10% when the model is re-simulated and compared to the clinical data. All identified parameter trends over time in the experiments match clinically expected changes both individually and over the cohort. This work represents a further clinical validation of these model-based cardiovascular diagnosis and therapy guidance methods for use with monitoring endotoxic disease states.
authors.affiliation: Centre for Bioengineering, University of Canterbury, Private Bag 4800, Christchurch, New Zealand. cst45@student.canterbury.ac.nz
authors.forename: C
authors.initials: C
authors.lastname: Starfinger
authors.forename: J G
authors.initials: JG
authors.lastname: Chase
authors.forename: C E
authors.initials: CE
authors.lastname: Hann
authors.forename: G M
authors.initials: GM
authors.lastname: Shaw
authors.forename: B
authors.initials: B
authors.lastname: Lambermont
authors.forename: A
authors.initials: A
authors.lastname: Ghuysen
authors.forename: P
authors.initials: P
authors.lastname: Kolh
authors.forename: P C
authors.initials: PC
authors.lastname: Dauby
authors.forename: T
authors.initials: T
authors.lastname: Desaive
mesh_terms: D000818:Animals; D003198:Computer Simulation; D004195:Disease Models, Animal; D006439:Hemodynamics; D006440:Hemofiltration; D008955:Models, Cardiovascular; D012772:Shock, Septic / Q000175:diagnosis* / Q000503:physiopathology; D013552:Swine