title: Dendritic nucleotides: interaction with an aliphatic acid monolayer.
abstract: Dendrimeric-T and dendrimeric-A with 36 nucleotides were synthesized using phosphoramidite reagents. These dendrimers contain the nucleosides dA and dT, which are the components of the dA-dT base pair. Branching was obtained using a bifurcated and trifurcated reagent. The dendrimers were purified by ion-exchange chromatography. No specific interactions between these dendrimers were observed using atomic force microscopy. However, the dendrimeric-T is able to disrupt monolayers of fatty acids, resulting in a reorientation of the lipids (from head-to-tail to head-to-head) as demonstrated by scanning tunneling microscopy (STM).
authors.affiliation: Division of Molecular and Nanomaterials, Department of Chemistry, K.U. Leuven, Celestijnenlaan 200 F, BE-3001 Heverlee.
authors.forename: Guojie
authors.initials: G
authors.lastname: Wang
authors.forename: Mikhail
authors.initials: M
authors.lastname: Abramov
authors.forename: Arthur
authors.initials: A
authors.lastname: Van Aerschot
authors.forename: Jef
authors.initials: J
authors.lastname: Rozenski
authors.forename: Shengbin
authors.initials: S
authors.lastname: Lei
authors.forename: Andrei
authors.initials: A
authors.lastname: Klymchenko
authors.forename: Mark
authors.initials: M
authors.lastname: Van der Auweraer
authors.forename: Steven
authors.initials: S
authors.lastname: De Feyter
authors.forename: Piet
authors.initials: P
authors.lastname: Herdewijn
mesh_terms: D002851:Chromatography, High Pressure Liquid; D050091:Dendrimers / Q000737:chemistry*; D005227:Fatty Acids / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D016252:Microscopy, Scanning Tunneling; D015394:Molecular Structure; D009711:Nucleotides / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D050091:Dendrimers; D005227:Fatty Acids; D009711:Nucleotides