title: A prospective randomized controlled trial of preimplantation genetic screening in the "good prognosis" patient.
abstract: OBJECTIVE
  To determine whether the routine use of preimplantation genetic screening (PGS) in "good prognosis" women improves in vitro fertilization (IVF) cycle outcome.
  
  
  METHODS
  Randomized, controlled, prospective clinical study.
  
  
  METHODS
  Private infertility clinic.
  
  
  METHODS
  Infertile women predicted to have a good prognosis as defined by: age <39 years, normal ovarian reserve, body mass index <30 kg/m(2), presence of ejaculated sperm, normal uterus, <or=2 previous failed IVF cycles.
  
  
  METHODS
  Patients were randomized to the PGS group or the control group on day 3 after oocyte retrieval; 23 women underwent blastomere biopsy on day 3 after fertilization (PGS group), and 24 women underwent routine IVF (control group). All embryos were transferred on day 5 or 6 after fertilization.
  
  
  METHODS
  Pregnancy, implantation, multiple gestation, and live birth rates.
  
  
  RESULTS
  No statistically significant differences were found between the PGS and control groups with respect to clinical pregnancy rate (52.4% versus 72.7%). However, the embryo implantation rate was statistically significantly lower for the PGS group (31.7% versus 62.3%) as were the live birth rate (28.6% versus 68.2%) and the multiple birth rate (9.1% versus 46.7%).
  
  
  CONCLUSIONS
  In a "good prognosis" population of women, PGS does not appear to improve pregnancy, implantation, or live birth rates.
authors.affiliation: Karande and Associates, Hoffman Estates, Illinois 60194, USA.
authors.forename: Liza R
authors.initials: LR
authors.lastname: Meyer
authors.forename: Sigal
authors.initials: S
authors.lastname: Klipstein
authors.forename: William D
authors.initials: WD
authors.lastname: Hazlett
authors.forename: Tricia
authors.initials: T
authors.lastname: Nasta
authors.forename: Patricia
authors.initials: P
authors.lastname: Mangan
authors.forename: Vishvanath C
authors.initials: VC
authors.lastname: Karande
mesh_terms: D000328:Adult; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D011247:Pregnancy; D018873:Pregnancy Rate; D019836:Preimplantation Diagnosis; D011379:Prognosis; D011446:Prospective Studies