title: Survival benefit of Boron neutron capture therapy for recurrent malignant gliomas.
abstract: We have applied boron neutron capture therapy (BNCT) to malignant brain tumors. Here we evaluated the survival benefit of BNCT for recurrent malignant glioma (MG). Since 2002, we have treated 22 cases of recurrent MG with BNCT. Survival time was analyzed with special reference to recursive partitioning analysis (RPA) classification, by Carson et al. (J Clin Oncol 25:2601-2606, 2007). Median survival times (MSTs) after BNCT for all patients and for glioblastoma as on-study histology at recurrence was 10.8 months (n = 22; 95% CI, 7.3-12.8 months) and 9.6 months (n = 19; 95% CI, 6.9-11.4 months), respectively. In our study, MST for the high-risk RPA classes was 9.1 months (n = 11; 95% CI, 4.4-11.0 months). By contrast, the original journal data showed that the MST of the same RPA classes was 4.4 months (n = 129; 95% CI, 3.6-5.4 months). BNCT showed a survival benefit for recurrent MG, especially in the high-risk group.
authors.affiliation: Department of Neurosurgery, Osaka Medical College, Takatsuki, Osaka, 569-8686, Japan. neu070@poh.osaka-med.ac.jp
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Miyatake
authors.forename: Shinji
authors.initials: S
authors.lastname: Kawabata
authors.forename: Kunio
authors.initials: K
authors.lastname: Yokoyama
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Kuroiwa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Michiue
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Sakurai
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kumada
authors.forename: Minoru
authors.initials: M
authors.lastname: Suzuki
authors.forename: Akira
authors.initials: A
authors.lastname: Maruhashi
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Kirihata
authors.forename: Koji
authors.initials: K
authors.lastname: Ono
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D001932:Brain Neoplasms / Q000401:mortality* / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D005910:Glioma / Q000401:mortality* / Q000532:radiotherapy*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000532:radiotherapy*; D009367:Neoplasm Staging; D012189:Retrospective Studies; D016896:Treatment Outcome