title: Isolation, structure determination, and synthesis of galaxamide, a rare cytotoxic cyclic pentapeptide from a marine algae Galaxaura filamentosa.
abstract: Galaxamide (1), a rare cyclic pentapeptide, was isolated from the marine algae Galaxaura filamentosa. A preliminary bioassay of Galaxamide showed remarkable in vitro antiproliferative activities against GRC-1 and HepG2 cell lines. The first total synthesis of the cyclic peptide was achieved for further biological evaluation.
authors.affiliation: Institute of Hydrobiology, Jinan University, Huangpu Road West 601, Guangzhou, Guangdong 510632, People's Republic of China.
authors.forename: Wen-Jie
authors.initials: WJ
authors.lastname: Xu
authors.forename: Xiao-Jian
authors.initials: XJ
authors.lastname: Liao
authors.forename: Shi-Hai
authors.initials: SH
authors.lastname: Xu
authors.forename: Jian-Zhong
authors.initials: JZ
authors.lastname: Diao
authors.forename: Bin
authors.initials: B
authors.lastname: Du
authors.forename: Xu-Long
authors.initials: XL
authors.lastname: Zhou
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Pan
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification* / Q000633:toxicity; D000461:Rhodophyta / Q000737:chemistry*
chemical_list: D010456:Peptides, Cyclic; C533373:galaxamide