The IL-17 cytokine family and their role in allergic inflammation.
Allergic diseases and asthma has long been hypothesized as the results of the dysregulation of type 2 immune responses to environmental allergens. Recent progresses in characterizing the proinflammatory IL-17 cytokine family have added additional layer of complexity on the regulation of allergic inflammation. The delineation of IL-17-producing CD4+ T cell subset (Th17) has led to the revision of Th1/Th2 paradigm and impacts our perspectives on the basis of chronic tissue inflammation. In addition, the distinctive expression patterns and biological activities of individual IL-17 cytokine member may play different roles in the regulation of the pathogenesis of allergic diseases. Understanding the cellular source and targeting cells of IL-17 cytokine family member will provide the basis to elucidate the cellular mechanism underlying allergic inflammation and improve our therapeutic approaches for allergy.
Wang
Yui-Hsi
YH
Division of Allergy and Immunology, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. Yui_hsi.Wang@cchmc.org
Liu
Yong-Jun
YJ
D000818:Animals; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007110:Immunity, Active; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology*; D020381:Interleukin-17 / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D020381:Interleukin-17