title: [Establishment of a mouse model of biliary obstruction and its dynamic observations].
abstract: OBJECTIVE
  To establish a mouse model of biliary obstruction.
  
  
  METHODS
  Sixty-four Balb/c mice were divided into experimental group and control group. Obstructive jaundice was induced in the mice in the experimental group by common bile duct ligation. The level of the common bile duct diameter, WBC, LYM MID, LYM%, MID% and ALT, AST, TBIL, DBIL, IBIL, ALP and CHOL were measured 12 h and 1, 2 ,3, 4, 5, and 7 days after the ligation. The morphological changes in the liver were also observed.
  
  
  RESULTS
  The level of common bile duct diameter, WBC, LYM, MID, LYM%, MID% and ALT, AST, TBIL, DBIL, ALP and CHOL all underwent changes with time following certain patterns.
  
  
  CONCLUSIONS
  The jaundice manifestation of this model is similar to that of patients with biliary obstruction, and this model may provide a reliable model for studying the mechanism of obstructive jaundice.
authors.affiliation: Department of Hepatobiliary Surgery, Nanfang Hospital.
authors.forename: Shou-hua
authors.initials: SH
authors.lastname: Zhang
authors.forename: Cai-xian
authors.initials: CX
authors.lastname: Liao
authors.forename: Chun-xing
authors.initials: CX
authors.lastname: Zhang
authors.forename: Hong
authors.initials: H
authors.lastname: Deng
authors.forename: Hang
authors.initials: H
authors.lastname: Zhu
authors.forename: Lei
authors.initials: L
authors.lastname: Lei
authors.forename: Chen
authors.initials: C
authors.lastname: Yao
mesh_terms: D000818:Animals; D001651:Cholestasis, Extrahepatic / Q000473:pathology*; D003135:Common Bile Duct / Q000473:pathology* / Q000601:surgery; D004195:Disease Models, Animal; D005260:Female; D008026:Ligation; D008099:Liver / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C