FGF signaling preserves the integrity of endothelial adherens junctions.
Fibroblast growth factor (FGF)-activated signaling regulates an array of cellular processes ranging from embryonic development to tissue repair. A recent paper by Murakami et al. identifies a potentially important role for FGF signaling in maintenance of endothelial barrier homeostasis through the regulation of adherens junctions.
Komarova
Yulia
Y
Department of Pharmacology and Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.
Malik
Asrar B
AB
Department of Pharmacology and Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA. Electronic address: abmalik@uic.edu.
D022005:Adherens Junctions / Q000378:metabolism*; D000818:Animals; D042783:Endothelial Cells / Q000166:cytology / Q000378:metabolism; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D051379:Mice; D008954:Models, Biological; D020033:Protein Isoforms / Q000378:metabolism; D017468:Receptors, Fibroblast Growth Factor / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D020033:Protein Isoforms; D017468:Receptors, Fibroblast Growth Factor; D042461:Vascular Endothelial Growth Factor A; D005346:Fibroblast Growth Factors