title: The in vitro and in vivo antiviral effects of salidroside from Rhodiola rosea L. against coxsackievirus B3.
abstract: The aim of this study was to investigate the antiviral effects of salidroside, a major component of Rhodiola rosea L. First, the antiviral effects of salidroside against coxsackievirus B3 (CVB3) were determined in vitro and in vivo. Then, the effect of salidroside on the mRNA expression of some important cytokines was measured in hearts of infected BALB/c mice by RT-PCR. Salidroside exhibited obvious antiviral effects both in in vitro and in vivo experiments. Salidroside was found to modulate the mRNA expression of interferon-gamma (IFN-gamma), interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-alpha), and interleukin-2 (IL-2). In conclusion, salidroside possesses antiviral activities against CVB3 and it may represent a potential therapeutic agent for viral myocarditis.
authors.affiliation: Department of Chemistry, The Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Haibo
authors.initials: H
authors.lastname: Wang
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Ding
authors.forename: Jun
authors.initials: J
authors.lastname: Zhou
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Sun
authors.forename: Siwang
authors.initials: S
authors.lastname: Wang
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D003384:Coxsackievirus Infections / Q000188:drug therapy*; D016207:Cytokines / Q000235:genetics / Q000378:metabolism*; D029822:Enterovirus B, Human / Q000187:drug effects*; D004798:Enzymes / Q000097:blood; D005960:Glucosides / Q000494:pharmacology* / Q000627:therapeutic use; D006321:Heart / Q000821:virology; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D051379:Mice; D008810:Mice, Inbred C57BL; D009206:Myocardium / Q000473:pathology; D010636:Phenols / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D029771:Rhodiola; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000998:Antiviral Agents; D016207:Cytokines; D004798:Enzymes; D005960:Glucosides; D010636:Phenols; D012333:RNA, Messenger; D008315:Malondialdehyde; D013482:Superoxide Dismutase; C009172:rhodioloside