title: Efficacy of computer aided analysis in detection of significant coronary artery stenosis in cardiac using dual source computed tomography.
abstract: OBJECTIVE
  To analyze the diagnostic efficacy of computer aided analysis of relevant coronary artery stenosis using dual source computed tomography (DSCT).
  
  
  METHODS
  In a larger scale study patients scheduled for conventional coronary angiography (CA) were additionally examined with DSCT. Based on a 13-segment model 30 CT scans of this study population were analyzed for significant stenosis using conventional 3D charts (3D) as well as a specialized cardiac analysis tool (CAT). Diagnostic accuracy and time to diagnosis was recorded for each vessel separately as well as the three readers' confidence.
  
  
  RESULTS
  With severe coronary artery calcifications, 53 false interpretations of segments were found for the total of 390 coronary segments analyzed. 3D and CAT analysis showed a Sensitivity, Specificity, PPV and NPV of 0.59, 0.91, 0.57, 0.92 and 0.57, 0.92, 0.56, 0.92, respectively. No significant differences in diagnostic accuracy could be found between 3D and CAT (P = 0.1667). 3D took a mean of 5.2 min (3-10 min). With CAT a mean time of 8.2 min (4-12 min) was needed. No significant inter-reader time differences (P = 0.4954) and no significant confidence level differences were found between readers and analyzes.
  
  
  CONCLUSIONS
  CAT of the coronary tree shows comparable accuracy to manual 3D analysis but needs improvements concerning coronary tree segmentation times.
authors.affiliation: Department of Diagnostic Imaging and Intervention, Diagnostic Radiology, University of Tuebingen, Hoppe Seyler Strasse 3, 72074 Tuebingen, Germany. anja.reimann@med.uni-tuebingen.de
authors.forename: Anja J
authors.initials: AJ
authors.lastname: Reimann
authors.forename: Ilias
authors.initials: I
authors.lastname: Tsiflikas
authors.forename: Harald
authors.initials: H
authors.lastname: Brodoefel
authors.forename: Michael
authors.initials: M
authors.lastname: Scheuering
authors.forename: Daniel
authors.initials: D
authors.lastname: Rinck
authors.forename: Andreas F
authors.initials: AF
authors.lastname: Kopp
authors.forename: Claus D
authors.initials: CD
authors.lastname: Claussen
authors.forename: Martin
authors.initials: M
authors.lastname: Heuschmid
mesh_terms: D000368:Aged; D003287:Contrast Media; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D007479:Iopamidol / Q000031:analogs & derivatives; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011857:Radiographic Image Interpretation, Computer-Assisted; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; C057937:iomeprol; D007479:Iopamidol