One-pot catalytic enantioselective domino nitro-michael/michael synthesis of cyclopentanes with four stereocenters.
A highly enantioselective organocatalytic one-pot synthesis of nitro-, formyl-, and ester-functionalized cyclopentanes with four stereocenters is presented. The cyclopentanes were formed as a predominant diasteroisomer and isolated in high yields with 97-99 % ee.
Zhao
Gui-Ling
GL
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 106 91 Stockholm, Sweden.
Ibrahem
Ismail
I
Dziedzic
Pawel
P
Sun
Junliang
J
Bonneau
Charlotte
C
Córdova
Armando
A