Inter-strain differences in glucocorticoid and mineralocorticoid effects on macrophage and lymphocyte functions in mice.
We showed previously and we confirm here that macrophages from three mouse strains are differentially sensitive to the inhibition of expression of key inflammatory proteins (iNOS-II, IL-1 beta) by dexamethasone, a specific glucocorticoid receptor agonist (C57BL/6>DBA/2>BALB/c). Here we show that aldosterone (a specific mineralocorticoid agonist) has no effect on iNOS-II or IL-1 beta expression in macrophages from these mouse strains but decreases IL-1ra expression, with small inter-strain differences. This mechanism may be involved in the pro-inflammatory effect of this hormone. Concanavalin A-stimulated lymphocytes proliferation is also differentially sensitive to dexamethasone according to the strain, but insensitive to aldosterone.
Harizi
H
H
Laboratoire PsyNuGen, INRA UMR1286, CNRS UMR5226, Université de Bordeaux 2, France. harizihedi33@yahoo.fr
Mormède
P
P
Corcuff
J-B
JB
D000450:Aldosterone / Q000494:pharmacology; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D016207:Cytokines / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005938:Glucocorticoids / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D008901:Mineralocorticoids / Q000494:pharmacology*; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D013045:Species Specificity
D016207:Cytokines; D005938:Glucocorticoids; D008901:Mineralocorticoids; D000450:Aldosterone; D003907:Dexamethasone; D052247:Nitric Oxide Synthase Type II