Interaction of trivalent antimony with a CCHC zinc finger domain: potential relevance to the mechanism of action of antimonial drugs.
Sb(III) competes with Zn(II) for its binding to the CCHC zinc finger domain of the NCp7 protein of HIV-1, indicating that zinc finger proteins may be targets for antimony-based drugs and thus responsible for their important pharmacological actions.
Demicheli
Cynthia
C
Departamento de Química, ICEX, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, Pampulha, 31270-901, Belo Horizonte, MG, Brazil. demichel@dedalus.lcc.ufmg.br
Frézard
Frédéric
F
Mangrum
John B
JB
Farrell
Nicholas P
NP
D000965:Antimony / Q000737:chemistry* / Q000494:pharmacology; D001667:Binding, Competitive; D006863:Hydrogen-Ion Concentration; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D015032:Zinc / Q000737:chemistry / Q000494:pharmacology; D016335:Zinc Fingers / Q000187:drug effects; D054301:gag Gene Products, Human Immunodeficiency Virus / Q000737:chemistry* / Q000187:drug effects
C071884:NCP7 protein, Human immunodeficiency virus 1; D009942:Organometallic Compounds; D054301:gag Gene Products, Human Immunodeficiency Virus; D000965:Antimony; D015032:Zinc