Rhabdastrellins A-F, isomalabaricane triterpenes from the marine sponge Rhabdastrella aff. distincta.
Chemical examination of the marine sponge Rhabdastrella aff. distincta resulted in the isolation of six new isomalabaricane triterpenes, rhabdastrellins A-F (1-6), which were present as minor components, along with stellettins L and M. Their structures were elucidated on the basis of extensive spectroscopic data analyses and comparison with spectroscopic data of known analogues. The cytotoxicity of compounds 1-6 against a small panel of human tumor cell lines was also evaluated.
Lv
Fang
F
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, People's Republic of China.
Xu
Minjuan
M
Deng
Zhiwei
Z
de Voogd
Nicole J
NJ
van Soest
Rob W M
RW
Proksch
Peter
P
Lin
Wenhan
W
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology
D000970:Antineoplastic Agents; D014315:Triterpenes; C522140:stellettin L