[Changes in the relationship between cognitive functioning and psychopathological symptoms in patients with paranoid schizophrenia in the periods of psychosis and development of remission].
The aim of our study was to investigate the relationship between cognitive functioning and psychopathological symptoms in patients with paranoid schizophrenia both in acute state and in the period of development of remission. Fourteen patients with paranoid schizophrenia (ICD-10, F20.0) were examined twice during 4,5-5 months, first--at the acute episode and second--at the period of development of remission during the treatment with olanzapine. The PANSS for assessment of psychopathological symptoms and Wechsler Adult Intelligence Scale (WAIS) and Benton Visual Retention Test as measures of cognitive functioning have been used. Though the patient's general cognitive functioning was in a normal range. The results of performance part (vs. verbal part) of the WAIS were significantly lower. The performance subtests idem were more sensible for changing in patient's actual status. The reduction of psychotic symptoms was accompanied by the improvement of almost all cognitive domains studied. The spectrum of interrelations between different aspects of cognition and clinical symptoms was revealed. These interrelations vary greatly in depending of the state of patients (exacerbation of psychosis or remission). During the remission, patient's cognitive functioning negatively correlated with two types of disorders: residual hallucinations and disturbance of verbal communication.
Morozova
M A
MA
Lepilkina
T A
TA
Rubashkina
V V
VV
D000208:Acute Disease; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D012074:Remission Induction; D012563:Schizophrenia, Paranoid / Q000175:diagnosis / Q000453:epidemiology*; D012565:Schizophrenic Psychology; D012720:Severity of Illness Index; D014888:Wechsler Scales
D014150:Antipsychotic Agents