title: [Reasons for proton-pump-inhibitor failure in the treatment of gastroesophageal reflux disease].
abstract: The introduction of proton pump inhibitors (PPI) has facilitated the successful management of patients with gastroesophageal reflux disease (GERD). In a minor, but still relevant proportion of patients with GERD-like symptoms, PPI therapy has also proved to be ineffective. In such cases, the first question to be answered is if the symptoms and complaints are related to GERD indeed, or another disorder should be searched for. If GERD is still the most likely diagnosis, patients' compliance should be thoroughly investigated before any further diagnostic and therapeutic measure is taken. If PPI failure is not a result of inadequate management of GERD, there are several other disorders to be ruled out. In our review, we summarize the most important differential diagnostic issues of PPI failure.
authors.affiliation: Semmelweis Egyetem, Altalános Orvostudományi Kar II, Belgyógyászati Klinika, Budapest, Szentkirályi u. 46, 1088. juhaszmarkdr@freemail.hu
authors.forename: Márk
authors.initials: M
authors.lastname: Juhász
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Tulassay
mesh_terms: D001682:Biological Availability; D003937:Diagnosis, Differential; D005764:Gastroesophageal Reflux / Q000175:diagnosis* / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D054328:Proton Pump Inhibitors / Q000493:pharmacokinetics / Q000627:therapeutic use*; D017211:Treatment Failure
chemical_list: D054328:Proton Pump Inhibitors