title: Facile preparation of alpha-aryl nitriles by direct cyanation of alcohols with TMSCN under the catalysis of InX3.
abstract: A convenient and efficient synthesis of alpha-aryl nitriles was developed by direct cyanation of alcohols with TMSCN under the catalysis of Lewis acid. Using 5-10 mol % of InBr3 as the catalyst, a variety of benzylic alcohols can be converted to the corresponding nitriles in 5-30 min with yields of 46-99%.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wang
authors.forename: Jiang
authors.initials: J
authors.lastname: Wu
authors.forename: Kuiling
authors.initials: K
authors.lastname: Ding
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D017605:Bromine Compounds / Q000737:chemistry*; D002384:Catalysis; D003486:Cyanides / Q000737:chemistry*; D005663:Furans / Q000737:chemistry*; D007204:Indium / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D014297:Trimethylsilyl Compounds / Q000737:chemistry*
chemical_list: D000438:Alcohols; D017605:Bromine Compounds; D003486:Cyanides; D005663:Furans; D009570:Nitriles; D014297:Trimethylsilyl Compounds; D007204:Indium; C058010:trimethylsilyl cyanide