title: Successful treatment of adrenocortical carcinoma with pulmonary metastasis in a child: report of a case.
abstract: Adrenocortical carcinoma (ACC) in childhood is rare: in 2002, only three new cases were reported in Japan. Although there is no established therapeutic management system, margin-free complete surgical excision of the tumor is very important to a satisfactory outcome. We report a case of ACC with bilateral pulmonary metastasis in a 10-year-old boy. Preoperative chest computed tomography (CT) showed pulmonary metastasis with near-water density. The patient was treated successfully with complete surgical resection of the primary tumor and adjuvant chemotherapy, including mitotane. After bilateral lung surgery for the metastatic lesions, the plasma dehydroepiandrosterone sulfate level became negative.
authors.affiliation: Department of General Surgery, Yokohama City University School of Medicine, 3-9 Fukuura Kanazawa-ku, Yokohama, 236-0004, Japan.
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Arai
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Rino
authors.forename: Sumitaka
authors.initials: S
authors.lastname: Yamanaka
authors.forename: Norio
authors.initials: N
authors.lastname: Yukawa
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Wada
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kato
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Yanagimachi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Goto
authors.forename: Hisashi
authors.initials: H
authors.lastname: Oshiro
authors.forename: Shoji
authors.initials: S
authors.lastname: Yamanaka
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Inayama
authors.forename: Jin
authors.initials: J
authors.lastname: Lee
authors.forename: Munetaka
authors.initials: M
authors.lastname: Masuda
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000473:pathology*; D018268:Adrenocortical Carcinoma / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D002648:Child; D003131:Combined Modality Therapy; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D008297:Male; D008939:Mitotane / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D018931:Antineoplastic Agents, Hormonal; D008939:Mitotane