title: Unlocking the power of cross-species genomic analyses: identification of evolutionarily conserved breast cancer networks and validation of preclinical models.
abstract: The application of high-throughput genomic technologies has revealed that individual breast tumors display a variety of molecular features that require more personalized approaches to treatment. Several recent studies have demonstrated that a cross-species analytic approach provides a powerful means to filter through genetic complexity by identifying evolutionarily conserved genetic networks that are fundamental to the oncogenic process. Mouse-human tumor comparisons will provide insights into cellular origins of tumor subtypes, define interactive oncogenetic networks, identify potential novel therapeutic targets, and further validate as well as guide the selection of genetically engineered mouse models for preclinical testing.
authors.affiliation: Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
authors.forename: Christina N
authors.initials: CN
authors.lastname: Bennett
authors.forename: Jeffrey E
authors.initials: JE
authors.lastname: Green
mesh_terms: D000230:Adenocarcinoma / Q000145:classification / Q000235:genetics* / Q000517:prevention & control / Q000556:secondary; D000818:Animals; D001943:Breast Neoplasms / Q000145:classification / Q000235:genetics* / Q000517:prevention & control; D017124:Conserved Sequence; D004273:DNA, Neoplasm / Q000235:genetics; D018450:Disease Progression; D016503:Drug Delivery Systems; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D044127:Epigenesis, Genetic; D019143:Evolution, Molecular; D005260:Female; D018628:Gene Dosage; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D052138:Genes, Neoplasm; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D051379:Mice; D018345:Mice, Knockout; D023421:Models, Animal; D009363:Neoplasm Proteins / Q000032:analysis / Q000235:genetics; D014411:Neoplastic Stem Cells / Q000473:pathology; D013045:Species Specificity; D054928:Validation Studies as Topic
chemical_list: D004273:DNA, Neoplasm; D009363:Neoplasm Proteins