The bradykinin B2 receptor in the early immune response against Listeria infection.
The endogenous danger signal bradykinin was recently found implicated in the development of immunity against parasites via dendritic cells. We here report an essential role of the B(2) (B(2)R) bradykinin receptor in the early immune response against Listeria infection. Mice deficient in B(2)R (B(2)R(-/-) mice) were shown to suffer from increased hepatic bacterial burden and concomitant dramatic weight loss during infection with Listeria monocytogenes. Levels of cytokines known to play a pivotal role in the early phase immune response against L. monocytogenes, IL-12p70 and IFN-gamma, were reduced in B(2)R(-/-) mice. To extend these findings to the human system, we show that bradykinin potentiates the production of IL-12p70 in human monocyte-derived dendritic cells. Thus, we show that bradykinin and the B(2)R play a role in early innate immune functions during bacterial infection.
Kaman
Wendy E
WE
TNO Defence, Security and Safety, Business Unit Biological and Chemical Protection, 2280 AA, Rijswijk, The Netherlands.
Wolterink
Arthur F W M
AF
Bader
Michael
M
Boele
Linda C L
LC
van der Kleij
Desiree
D
D000818:Animals; D001835:Body Weight; D001920:Bradykinin / Q000276:immunology; D002478:Cells, Cultured; D016207:Cytokines / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D018664:Interleukin-12 / Q000096:biosynthesis; D008089:Listeria monocytogenes / Q000276:immunology*; D008088:Listeriosis / Q000276:immunology*; D008099:Liver / Q000382:microbiology; D051379:Mice; D018345:Mice, Knockout; D043782:Receptor, Bradykinin B2 / Q000172:deficiency / Q000276:immunology*
D016207:Cytokines; D043782:Receptor, Bradykinin B2; D018664:Interleukin-12; D007371:Interferon-gamma; D001920:Bradykinin