title: SERRS immunoassay for quantitative human CRP analysis.
abstract: SERRS has been used for the first time for the measurement of C-reactive protein (CRP) in an immunoassay. CRP, a biological marker for the diagnosis of infection and inflammation, is quantified in an ELISA using conventional reagents, but the usual colorimetric detection step is replaced by SERRS detection, offering improved sensitivity and potential for multiplexing analysis.
authors.affiliation: Division of Animal Production & Public Health, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, UK.
authors.forename: Fiona M
authors.initials: FM
authors.lastname: Campbell
authors.forename: Andrew
authors.initials: A
authors.lastname: Ingram
authors.forename: Paul
authors.initials: P
authors.lastname: Monaghan
authors.forename: Jon
authors.initials: J
authors.lastname: Cooper
authors.forename: Naveed
authors.initials: N
authors.lastname: Sattar
authors.forename: P David
authors.initials: PD
authors.lastname: Eckersall
authors.forename: Duncan
authors.initials: D
authors.lastname: Graham
mesh_terms: D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D004396:Coloring Agents; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D006046:Gold; D006801:Humans; D053758:Nanoparticles; D012680:Sensitivity and Specificity; D013059:Spectrum Analysis, Raman / Q000379:methods
chemical_list: D015415:Biomarkers; D004396:Coloring Agents; D006046:Gold; D002097:C-Reactive Protein