title: Site-specific self-cleavage of G-quadruplexes formed by human telemetric repeats.
abstract: It is demonstrated in our investigations that certain G-quadruplex structures formed by human telomeric repeats could perform self-cleaving actions. Our further studies verify that these reactions are site-specific and undergo hydrolytic pathways.
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, SPMS-CBC-04-21, Singapore 637616, Singapore.
authors.forename: Xinming
authors.initials: X
authors.lastname: Li
authors.forename: Magdeline Tao Tao
authors.initials: MT
authors.lastname: Ng
authors.forename: Yifan
authors.initials: Y
authors.lastname: Wang
authors.forename: Tianyan
authors.initials: T
authors.lastname: Zhou
authors.forename: Sock Teng
authors.initials: ST
authors.lastname: Chua
authors.forename: Weixing
authors.initials: W
authors.lastname: Yuan
authors.forename: Tianhu
authors.initials: T
authors.lastname: Li
mesh_terms: D020137:Base Pair Mismatch; D001483:Base Sequence; D004247:DNA / Q000737:chemistry; D054856:G-Quadruplexes; D006801:Humans; D006868:Hydrolysis; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D009692:Nucleic Acid Heteroduplexes / Q000737:chemistry; D009841:Oligonucleotides / Q000737:chemistry; D010710:Phosphates / Q000737:chemistry; D016615:Telomere / Q000648:ultrastructure*; D013997:Time Factors
chemical_list: D009692:Nucleic Acid Heteroduplexes; D009841:Oligonucleotides; D010710:Phosphates; D004247:DNA