title: Epstein-Barr virus load in cerebrospinal fluid of patients with chronic active Epstein-Barr virus infection.
abstract: Chronic active Epstein-Barr virus (EBV) infection is a rare chronic mononucleosis syndrome involving clonally proliferating EBV-infected T-/NK-cells. EBV DNA was quantified in nonpleocytotic cerebrospinal fluid (CSF) of 9 patients. Three patients with neurologic and/or neuroimaging abnormalities showed high CSF copy numbers. In 1 patient, CSF copy number exceeded the peripheral blood value. CSF EBV-load may predict the central nervous system involvement of EBVT-/NK-cells.
authors.affiliation: Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. ohgas@pediatr.med.kyushu-u.ac.jp
authors.forename: Shouichi
authors.initials: S
authors.lastname: Ohga
authors.forename: Masafumi
authors.initials: M
authors.lastname: Sanefuji
authors.forename: Masataka
authors.initials: M
authors.lastname: Ishimura
authors.forename: Akihiko
authors.initials: A
authors.lastname: Nomura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Torisu
authors.forename: Ryutaro
authors.initials: R
authors.lastname: Kira
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Takada
authors.forename: Yumi
authors.initials: Y
authors.lastname: Mizuno
authors.forename: Yukumasa
authors.initials: Y
authors.lastname: Kazuyama
authors.forename: Toshiro
authors.initials: T
authors.lastname: Hara
mesh_terms: D000293:Adolescent; D000328:Adult; D002555:Cerebrospinal Fluid / Q000821:virology*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D006801:Humans; D007244:Infectious Mononucleosis / Q000134:cerebrospinal fluid / Q000821:virology*; D007694:Killer Cells, Natural; D008279:Magnetic Resonance Imaging; D008297:Male; D016133:Polymerase Chain Reaction; D013601:T-Lymphocytes; D019562:Viral Load