title: Family history and age at onset of breast cancer in Hispanic and non-Hispanic white women.
abstract: OBJECTIVE
  To evaluate the association between family history of breast cancer and breast cancer risk among Hispanic and non-Hispanic white (NHW) women.
  
  
  METHODS
  Logistic regression models were used to compute unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) using data collected from the 4-Corners Breast Cancer Study, a population-based case-control study of breast cancer conducted in the Southwest United States (3,074 NHW and 1,647 Hispanic women).
  
  
  RESULTS
  The association between family history of breast cancer and early-onset breast cancer risk differs among NHW and Hispanic women. Among women <50 years old, having a family history of breast cancer was associated with a greater increase in risk among NHWs, with an OR of 2.34 (95% CI: 1.64-3.35) when compared to an OR of 1.32 (95% CI: 0.82-2.19) for Hispanics. This difference in risk was not observed among women 50 years and older, with an OR of 1.69 (95% CI: 1.34-2.13) for NHW and 1.47 (95% CI: 1.03-2.10) for Hispanics.
  
  
  CONCLUSIONS
  Family history of breast cancer poses a greater risk for early-onset breast cancers among NHW when compared to Hispanic women and may reflect ethnic differences in certain predisposing genetic factors that promote breast cancer development.
authors.affiliation: Department of Preventive Medicine and Biometrics, University of Colorado at Denver and Health Sciences, Aurora, CO 80045, USA. betsy.risendal@uchsc.edu
authors.forename: Betsy
authors.initials: B
authors.lastname: Risendal
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Hines
authors.forename: Carol
authors.initials: C
authors.lastname: Sweeney
authors.forename: Martha L
authors.initials: ML
authors.lastname: Slattery
authors.forename: Anna R
authors.initials: AR
authors.lastname: Giuliano
authors.forename: Kathy B
authors.initials: KB
authors.lastname: Baumgartner
authors.forename: Karen
authors.initials: K
authors.lastname: Curtin
authors.forename: Tim E
authors.initials: TE
authors.lastname: Byers
mesh_terms: D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D000368:Aged; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000208:ethnology* / Q000235:genetics; D016022:Case-Control Studies; D016001:Confidence Intervals; D015986:Confounding Factors, Epidemiologic; D005192:Family Health / Q000208:ethnology*; D005260:Female; D020022:Genetic Predisposition to Disease; D006630:Hispanic or Latino / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D007407:Interviews as Topic; D016015:Logistic Models; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014481:United States / Q000453:epidemiology / Q000208:ethnology; D044465:White People / Q000706:statistics & numerical data*