Clinicopathological significance of overexpression of TSPAN1, Ki67 and CD34 in gastric carcinoma.
To investigate the expression of TSPAN1 (Gene ID: 10103), Ki67 and CD34 in gastric carcinomas and the clinicopathological significance, the expression of TSPAN1, Ki67 and CD34 was detected in 86 cases of gastric carcinoma, paraffin-embedded sections using an immunohistochemical method. The rates of overexpression of TSPAN1, Ki67 and CD34 in gastric carcinomas were 56.98%, 74.42%, and 62.79%, respectively. The overexpression of these markers was positively correlated with clinical stage and negatively correlated with survival rates (at 3 and 5 years). The overexpression of TSPAN1 and Ki67 was negatively correlated with carcinoma differentiation, and the overexpression of TSPAN1 and CD34 was positively correlated with infiltration and lymph node status of the tumor. Thus, overexpression of TSPAN1, Ki67 and CD34 in gastric cancer tissues is associated with development of the cancer. The detection of expression of TSPAN1, Ki67 and CD34 in gastric cancer may provide useful prognostic information for patients with the disease.
Chen
Li
L
Department of Pathological Anatomy, Nantong University Nantong, China.
Li
Xinyu
X
Wang
Guei-Lan
GL
Wang
Yu
Y
Zhu
York-Yuan
YY
Zhu
Jianwei
J
D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002277:Carcinoma / Q000737:chemistry* / Q000401:mortality / Q000473:pathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D019394:Ki-67 Antigen / Q000032:analysis*; D008297:Male; D008565:Membrane Proteins / Q000032:analysis*; D008875:Middle Aged; D009367:Neoplasm Staging; D013274:Stomach Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology*; D059470:Tetraspanins; D015854:Up-Regulation
D018952:Antigens, CD34; D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D008565:Membrane Proteins; C508125:TSPAN1 protein, human; D059470:Tetraspanins