title: Comparison of rehabilitation results in deaf patients with and without genetically related hearing loss.
abstract: The introduction of prognostic tools to evaluate rehabilitation progress in cochlear implant patients (CI patients) is of great importance. The authors attempted to verify whether the identified 35delG mutation in the GJB2 gene can serve as a valuable indicator for rehabilitation progress of CI patients. A group of 51 subjects was studied. Molecular analysis was based on the identification of 35delG in GJB2. Logopedic assessment was performed with a non-verbal test of seven sounds, evaluating detection, discrimination and identification of the sounds during the first, third and sixth months after implantation. Results indicated that patients with GJB2-related deafness (DFNB1)s achieve better results in rehabilitation, but only at the early stages of rehabilitation. Prolonged rehabilitation equalised differences, which, subsequently, excluded this marker as an indicator for rehabilitation evaluation.
authors.affiliation: Otolaryngology Department, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Wróbel
authors.forename: Magdalena
authors.initials: M
authors.lastname: Magierska-Krzysztoń
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Szyfter
authors.forename: Dorota
authors.initials: D
authors.lastname: Mietkiewska
authors.forename: Witold
authors.initials: W
authors.lastname: Szyfter
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Rydzanicz
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Szyfter
authors.forename: Michał
authors.initials: M
authors.lastname: Karlik
mesh_terms: D000293:Adolescent; D000072259:Connexin 26; D017630:Connexins / Q000235:genetics; D017931:DNA Primers / Q000235:genetics; D003638:Deafness / Q000453:epidemiology / Q000235:genetics / Q000534:rehabilitation; D005260:Female; D006801:Humans; D008297:Male; D017354:Point Mutation / Q000235:genetics; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D017630:Connexins; D017931:DNA Primers; C000607042:GJB2 protein, human; D000072259:Connexin 26