Synthesis of beta-, gamma-, and delta-lactams via Pd(II)-catalyzed C-H activation reactions.
Pd(II)-catalyzed intramolecular amination of sp2 and sp3 C-H bonds are developed using a combination of CuCl2 and AgOAc as the oxidant. The reaction protocol tolerates the presence of a double bond in the substrates. This catalytic reaction provides practical access to a wide range of beta-, gamma-, and delta-lactams.
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Masayuki
M
Wasa
Jin-Quan
JQ
Yu
D000085:Acetates / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D007769:Lactams / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D018030:Silver Compounds / Q000737:chemistry; D013237:Stereoisomerism
D000085:Acetates; D007769:Lactams; D018030:Silver Compounds; C103100:silver acetate; D010165:Palladium; D003300:Copper; C029892:cupric chloride