Metabolic syndrome: from epidemiology to systems biology.
Metabolic syndrome (MetSyn) is a group of metabolic conditions that occur together and promote the development of cardiovascular disease (CVD) and diabetes. Recent genome-wide association studies have identified several novel susceptibility genes for MetSyn traits, and studies in rodent models have provided important molecular insights. However, as yet, only a small fraction of the genetic component is known. Systems-based approaches that integrate genomic, molecular and physiological data are complementing traditional genetic and biochemical approaches to more fully address the complexity of MetSyn.
Lusis
Aldons J
AJ
Department of Medicine and Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA. jlusis@mednet.ucla.edu
Attie
Alan D
AD
Reue
Karen
K
D044127:Epigenesis, Genetic / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation; D023281:Genomics / Q000379:methods; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics*; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000235:genetics*; D012307:Risk Factors; D012737:Sex Factors; D049490:Systems Biology / Q000379:methods*