Functional serotonin 1A receptor variant influences treatment response to atypical antipsychotics in schizophrenia.
The serotonin (5-HT) 1A receptor has been found to be dysregulated in prefrontal cortex and other brain regions in schizophrenia, and 5-HT1A receptor levels in the amygdala have been related to negative schizophrenia symptoms. We have assessed the impact of the functional C-1019G variant of the 5-HT1A receptor on the response to risperidone or haloperidol in a prospective, randomized, double-blind study. Patients were treated for 4 weeks and negative symptoms assessed weekly. The variant influenced the response to risperidone: improvement of negative symptoms by 4.38 points for carriers of the C allele, compared with the GG genotype (1.22 points, P=0.046). In a second independent study of 130 schizophrenia patients treated with atypical antipsychotics, this effect was confirmed (P=0.003). The functional variant of the 5-HT1A receptor thus influences the response of schizophrenia patients to atypical antipsychotics and may be useful in the future to predict the pharmacogenetics of negative symptoms.
Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany. rainald.moessner@ukb.uni-bonn.de
Rainald
R
Mössner
Anna
A
Schuhmacher
Kai-Uwe
KU
Kühn
Gabriela
G
Cvetanovska
Dan
D
Rujescu
Peter
P
Zill
Boris B
BB
Quednow
Marcella
M
Rietschel
Wolfgang
W
Wölwer
Wolfgang
W
Gaebel
Michael
M
Wagner
Wolfgang
W
Maier
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005838:Genotype; D006220:Haloperidol / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics*; D018967:Risperidone / Q000627:therapeutic use; D012559:Schizophrenia / Q000188:drug therapy* / Q000235:genetics*; D055815:Young Adult
D014150:Antipsychotic Agents; D044282:Receptor, Serotonin, 5-HT1A; D006220:Haloperidol; D018967:Risperidone