Synthesis, antioxidative and antiviral activity of hydroxycinnamic acid amides of thiazole containing amino acid.
The synthesis and the biological (antioxidant and antiviral) activities of novel hydroxycinnamic acid amides of a thiazole containing TFA.valine-4-carboxylic acid ethyl ester are reported. The amides have been synthesized from p-coumaric, ferulic and sinapic acids with the corresponding TFA.valine-thiazole-4-carboxylic acid ethyl ester using the coupling reagent N-ethyl-N'-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) and 4-(dimethylamino) pyridine (DMAP) as a catalyst. The antioxidant properties of the newly synthesized amides have been studied for then antioxidative activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH)* test. The newly synthesized compounds have been tested against the replication in vitro of influenza virus A (H3N2) and human herpes virus 1 and 2 (HSV-1 and HSV-2).
Department of Chemistry, South-West University Neofit Rilski, 2700 Blagoevgrad, Bulgaria. ivankast@aix.swu.bg
Ivanka
I
Stankova
Kiril
K
Chuchkov
Stoyan
S
Shishkov
Kalina
K
Kostova
Luchia
L
Mukova
Angel S
AS
Galabov
D000596:Amino Acids / Q000737:chemistry*; D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D001713:Biphenyl Compounds / Q000378:metabolism; D002460:Cell Line; D003373:Coumaric Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D016166:Free Radical Scavengers / Q000378:metabolism; D005609:Free Radicals / Q000378:metabolism; D018259:Herpesvirus 1, Human / Q000502:physiology; D018258:Herpesvirus 2, Human / Q000502:physiology; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D010851:Picrates / Q000378:metabolism; D013844:Thiazoles / Q000737:chemistry*; D014779:Virus Replication
D000596:Amino Acids; D000975:Antioxidants; D000998:Antiviral Agents; D001713:Biphenyl Compounds; D003373:Coumaric Acids; D016166:Free Radical Scavengers; D005609:Free Radicals; D010851:Picrates; D013844:Thiazoles; C004931:1,1-diphenyl-2-picrylhydrazyl