[Increased risk of neoplasia among relatives of glioma patients].
BACKGROUND
Some previous studies have suggested familial aggregation of gliomas, although the results have not always been replicated.


METHODS
In the present study of a Mexican population, we compared 100 cases of glioma with 124 healthy unrelated controls, as well as their 1st, 2nd and 3rd degree relatives (n = 3,575 and 4,520 respectively).


RESULTS
The relatives of the cases had a significantly higher risk of developing brain tumors than the relatives of controls (OR = 5.3; p < 0.05; 95% CI = 1.1-25.7), and their risk of developing any cancer was also increased (OR = 2; p < 0.05; 95% CI = 1.16-3.51), this risk was twofold for men when compared to females (OR = 2; p < 0.05; 95% CI = 1.15-3.37).


CONCLUSIONS
The present study supports familial aggregation of brain tumors and warrants further research into their genetic etiology.
Departamento de Neurogenética y Biología Molecular, Instituto Nacional de Neurologíay Neurocirugía Manuel Velasco Suárez, México DF, México.
A
A
González-Aguilar
P
P
Gutiérrez-Castrellón
E
E
Briceño
D
D
Rembao-Bojórquez
M E
ME
Alonso-Vilatela
A
A
Rasmussen
D001932:Brain Neoplasms / Q000453:epidemiology / Q000235:genetics; D005192:Family Health; D005260:Female; D020022:Genetic Predisposition to Disease; D005910:Glioma / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D012307:Risk Factors; D011795:Surveys and Questionnaires
Incremento en el riesgo de neoplasia entre familiares de pacientes con glioma.