Modeling the effects of resection, radiation and chemotherapy in glioblastoma.
The standard treatment for newly diagnosed glioblastoma multiforme is surgical resection followed by radiotherapy and chemotherapy. Most studies on these treatments are retrospective clinical data analysis. To integrate these studies, a mathematical model is developed. The model predicts the survival time of patients who undergo resection, radiation, and chemotherapy with different protocols.
Mathematics Department, The College of William and Mary, Williamsburg, VA, USA. jptian@math.wm.edu
Jianjun Paul
JP
Tian
Avner
A
Friedman
Jin
J
Wang
E Antonio
EA
Chiocca
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000628:therapy*; D003131:Combined Modality Therapy / Q000379:methods; D005909:Glioblastoma / Q000628:therapy*; D006801:Humans; D008954:Models, Biological; D019635:Neurosurgical Procedures / Q000379:methods*; D011878:Radiotherapy; D013997:Time Factors
D000970:Antineoplastic Agents