Neuromodulation by paired-pulse TMS at an I-wave interval facilitates multiple I-waves.
Corticospinal excitability can be increased by a transcranial magnetic stimulation (TMS) intervention that delivers repeated paired TMS pulses at an I (indirect)-wave interval of 1.5 ms. This is thought to target excitatory synaptic events by reinforcing facilitatory I-wave interaction, however, it remains to be determined what effect this intervention has on the various I-wave components. In the present study we compared I-wave facilitation curves over a range of inter-pulse intervals (IPIs) encompassing the first three I-waves, before and after 15 min of a paired-pulse TMS intervention with an IPI of 1.5 ms. The three peaks in the I-wave facilitation curves occurred at the same IPIs pre- and post-intervention (1.3, 2.5 and 4.3 ms). The facilitation curves were increased in amplitude for all three I-wave peaks post-intervention (mean increase 33%), and the mean increase across all IPIs correlated with the post-intervention increase in single-pulse MEP amplitude (r = 0.77). Modelling showed that the changes in the post-intervention curves were consistent with an increase in amplitude and broadening of the individual I-wave peaks. We conclude that an iTMS intervention with an IPI of 1.5 ms is able to target multiple I-waves. The findings are consistent with existing models of I-wave generation and suggest that the intervention increases the efficacy of synaptic events associated with the generation of descending I-wave volleys.
Cash
R F H
RF
Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Crawley, WA, Australia. rcash@cyllene.uwa.edu.au
Benwell
N M
NM
Murray
K
K
Mastaglia
F L
FL
Thickbroom
G W
GW
D000293:Adolescent; D000328:Adult; D004576:Electromyography; D019054:Evoked Potentials, Motor; D005260:Female; D006801:Humans; D007395:Interneurons / Q000502:physiology; D016014:Linear Models; D008297:Male; D009474:Neurons / Q000502:physiology*; D012044:Regression Analysis; D050781:Transcranial Magnetic Stimulation; D055815:Young Adult