Wound repair capability in EDS fibroblasts can be retrieved by exogenous type V collagen.
Impaired wound healing is a typical clinical hallmark of Ehlers-Danlos Syndrome (EDS). Mutated fibroblasts from EDS patients, which deposit an abnormal extracellular matrix, showed defective migration resulting in a marked delay in wound repair. The migratory capability remarkably improved in the presence of exogenous type V collagen.
Department of Biochemistry A. Castellani, University of Pavia, 27100 Pavia, Italy.
Simona
S
Viglio
Nicoletta
N
Zoppi
Antonella
A
Sangalli
Angelo
A
Gallanti
Sergio
S
Barlati
Monica
M
Mottes
Marina
M
Colombi
Maurizia
M
Valli
D024062:Collagen Type V / Q000627:therapeutic use*; D004535:Ehlers-Danlos Syndrome / Q000188:drug therapy*; D005347:Fibroblasts / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology*
D024062:Collagen Type V