The microRNA-200 family regulates epithelial to mesenchymal transition.
Epithelial-mesenchymal transition (EMT) is implicated in metastasis initiation and has recently been shown to be regulated by the miRNA-200 family and miR-205. Expression of these miRNAs was lost in invasive breast cancer cell lines displaying mesenchymal-like morphology suggesting these microRNAs may play a role in cancer metastasis.
Paterson
Emily L
EL
Hanson Institute and Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, SA 5000, Australia. emily.paterson@imvs.sa.gov.au
Kolesnikoff
Natasha
N
Gregory
Philip A
PA
Bert
Andrew G
AG
Khew-Goodall
Yeesim
Y
Goodall
Gregory J
GJ
D000818:Animals; D002460:Cell Line; D004285:Dogs; D004848:Epithelium / Q000502:physiology; D018398:Homeodomain Proteins / Q000502:physiology; D006801:Humans; D008648:Mesoderm / Q000502:physiology; D035683:MicroRNAs / Q000502:physiology*; D009362:Neoplasm Metastasis / Q000503:physiopathology; D009369:Neoplasms / Q000209:etiology*; D009419:Nerve Tissue Proteins / Q000502:physiology; D016601:RNA-Binding Proteins / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology; D000071799:Zinc Finger E-box-Binding Homeobox 1
C108381:GEMIN2 protein, human; D018398:Homeodomain Proteins; D035683:MicroRNAs; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins; D014157:Transcription Factors; C486307:ZEB1 protein, human; D000071799:Zinc Finger E-box-Binding Homeobox 1