Malignant fibrous histiocytoma of the sinonasal tract.
BACKGROUND
Sinonasal malignant fibrous histiocytoma (MFH) is rare.


METHODS
Twenty-five patients were registered with a diagnosis of sinonasal MFH at our hospital in the past 30 years. Clinical data were retrospectively reviewed.


RESULTS
Eight tumors were primary MFH and 17 tumors were post-irradiated MFH, located within the radiation field for previous nasopharyngeal carcinoma. Twenty-one tumors originated from the maxillary sinus, 3 from the nasopharynx, and 1 from the nasal cavity. Twenty-three patients underwent surgery but only 12 tumors were removed completely. The 5-year overall and disease-free survival rates were 25.1% and 21.5%, respectively. Multivariate analyses showed that previous radiation was the only adverse prognostic factor for disease-free survival (p = .045). The 5-year disease-free survival rates of primary MFH and post-irradiated MFH were 72.9% and 0%.


CONCLUSIONS
In this series, post-irradiated MFH was more common than primary MFH. The prognosis of post-irradiated MFH is poor, whereas primary MFH is fair.
Wang
Cheng-Ping
CP
Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan.
Chang
Yih-Leong
YL
Ting
Lai-Lei
LL
Yang
Tsung-Lin
TL
Ko
Jenq-Yuh
JY
Lou
Pei-Jen
PJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D018572:Disease-Free Survival; D005260:Female; D006258:Head and Neck Neoplasms / Q000209:etiology / Q000401:mortality* / Q000532:radiotherapy / Q000601:surgery; D051677:Histiocytoma, Malignant Fibrous / Q000209:etiology / Q000401:mortality* / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000532:radiotherapy*; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology / Q000401:mortality*; D011379:Prognosis; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D055815:Young Adult