Transcriptional changes in human Caco-2 colon cancer cells following exposure to a recurrent non-toxic dose of polyphenol-rich chokeberry juice.
Berries and red fruits are important dietary sources of polyphenols [1]. In vitro and animal studies have demonstrated the bioavailability and the anti-proliferative and anticarcinogenic properties of these fruits or of their phenolic components [2, 3]. Consumption of berries may contribute to the reduction of colon cancer by mechanisms not yet understood. Gene expression analysis using microarrays allows for a more comprehensive study of the possible molecular mechanisms by which food or food components may prevent certain cancers of the gastrointestinal tract [4]. The aim of this research is to investigate the anti-proliferative effects of a polyphenol-rich berry juice on a human model of colon cancer cells and its association to transcriptional changes in relation to colon cancer.
Bermúdez-Soto
M J
MJ
Research Group on Quality, Safety and Bioactivity of Plant Foods, Food Science and Technology, CEBAS-CSIC, Campus de Espinardo, 30100, Murcia, Spain.
Larrosa
M
M
García-Cantalejo
J
J
Espín
J C
JC
Tomás-Barberan
F A
FA
García-Conesa
M T
MT