Tissue reaction to intramuscular injection of resorbable polymer microparticles.
Tissue reaction to implantation of polymeric microparticles from resorbable polymer (polyhydroxybutyrate) is characterized by slight inflammatory reaction and pronounced progressive macrophage infiltration with the presence of mono- and multinuclear foreign body giant cells resorbing the polymeric matrix. No fibrous capsules were formed around the polymeric microparticles; neither necrosis nor other adverse morphological changes and tissue transformation in response to implantation of the PHB microparticles were recorded. The results indicate good prospects of using polyhydroxybutyrate for the construction of long-acting dosage forms as microparticles for intramuscular injection.
Institute of Biophysics, Siberian Division of Russian Academy of Sciences, Krasnoyarsk.
E I
EI
Shishatskaya
O N
ON
Voinova
A V
AV
Goreva
O A
OA
Mogilnaya
T G
TG
Volova
D020341:Absorbable Implants; D000818:Animals; D004339:Drug Compounding; D005260:Female; D005549:Foreign-Body Reaction / Q000473:pathology; D007273:Injections, Intramuscular; D008863:Microspheres; D011091:Polyesters / Q000008:administration & dosage* / Q000009:adverse effects; D000091402:Prohibitins; D051381:Rats; D017208:Rats, Wistar
C000717332:Phb protein, rat; D011091:Polyesters; D000091402:Prohibitins