Annexin A1 and the formyl peptide receptor family: neuroendocrine and metabolic aspects.
Annexin A1 (ANXA1, formerly termed lipocortin 1 or macrocortin) is an important protein mediator of the feedback actions of glucocorticoids within the hypothalamo-pituitary-adrenocortical (HPA) axis. Here we consider the mechanisms by which ANXA1 exerts these actions, with particular reference to the potential role of the formyl peptide receptors (FPRs), a family of G-protein-coupled receptors which has only very recently been implicated in the regulation of neuroendocrine function. In addition, we discuss evidence that ANXA1 contributes to the regulation of other aspects of endocrine and metabolic function and to the aetiology of sexual dimorphisms.
John
Christopher D
CD
Division of Neuroscience and Mental Health, Imperial College London, Hammersmith Campus, London, UK.
Gavins
Felicity N E
FN
Buss
Nicholas A P S
NA
Cover
Patricia O
PO
Buckingham
Julia C
JC
D000818:Animals; D017305:Annexin A1 / Q000378:metabolism / Q000502:physiology*; D005938:Glucocorticoids / Q000378:metabolism / Q000502:physiology; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D008954:Models, Biological; D010913:Pituitary-Adrenal System / Q000502:physiology*; D044042:Receptors, Formyl Peptide / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
D017305:Annexin A1; D005938:Glucocorticoids; D044042:Receptors, Formyl Peptide