Cardiac biomarkers and chronic renal diseases.
Accelerated atherosclerosis can lead to an increased prevalence of coronary artery disease, heart failure, brain stroke and peripheral arterial disease. Thus, subjects with chronic renal failure are exposed to increased morbidity and mortality from cardiovascular events. A strong and pervasive link exists between kidney failure and cardiac disease. A variety of individual biomarkers have been evaluated and several have been found to successfully predict the outcome in patients with kidney disease. These include markers of myocardial necrosis, such as cardiac troponin T and I, markers of heart failure, such as B-type of natriuretic peptide and its associated inactive N-terminal fragment, markers of systemic inflammation--C-reactive protein, and an endogenous inhibitor of nitric oxide synthase-asymmetric dimethyl arginin. Increased concentrations of C-reactive protein, B-type of natriuretic peptide, asymmetric dimethyl arginine, and troponin predict a high risk of cardiovascular mortality as well as a mortality due to other causes in patients with chronic renal failure or end stage renal disease (Tab. 1, Ref. 33). Full Text (Free, PDF) www.bmj.sk.
1st Department of Internal Medicine, University Hospital, Safarikiensis University, Kosice, Slovakia. irosochova@hotmail.com
I
I
Valocikova
B
B
Kristofova
G
G
Valocik
D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis; D003324:Coronary Artery Disease / Q000150:complications / Q000175:diagnosis*; D018450:Disease Progression; D006710:Homocysteine / Q000097:blood; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000175:diagnosis*; D020097:Natriuretic Peptide, Brain / Q000097:blood; D014336:Troponin / Q000097:blood
D015415:Biomarkers; D014336:Troponin; D006710:Homocysteine; D020097:Natriuretic Peptide, Brain; C018524:N,N-dimethylarginine; D002097:C-Reactive Protein; D001120:Arginine