Adherence to biomedical HIV prevention methods: considerations drawn from HIV treatment adherence research.
Biomedical approaches to HIV prevention (eg, microbicides, antiretroviral preexposure prophylaxis) are undergoing clinical trials to test their efficacy. One key consideration emerging from completed trials is the critical role of adherence to the investigational product. Suboptimal product adherence may compromise clinical trial results and ultimately undermine the effectiveness of biomedical prevention methods in any future real-world use. Efforts to strengthen biomedical HIV prevention product adherence can benefit from existing research methodologies, findings, and interventions developed for adherence to HIV treatment. Research on treatment adherence is most relevant to medication-based biomedical prevention strategies, such as antiretroviral preexposure prophylaxis and acyclovir for herpes simplex virus-2. Three areas where HIV treatment adherence literature can inform research on such biomedical prevention strategies are 1) specialized methods for assessing medication adherence, 2) research findings emphasizing social context as an adherence determinant, and 3) promising behavioral interventions to improve adherence.
Center for Mental Health Research on AIDS, National Institute of Mental Health, 6001 Executive Boulevard, Room 6199, Bethesda, MD 20892, USA. stirrattm@mail.nih.gov
Michael J
MJ
Stirratt
Christopher M
CM
Gordon
D000212:Acyclovir / Q000627:therapeutic use*; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D001521:Behavior Therapy / Q000379:methods; D018890:Chemoprevention; D002986:Clinical Trials as Topic; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000517:prevention & control* / Q000821:virology; D006558:Herpes Genitalis / Q000188:drug therapy / Q000517:prevention & control / Q000821:virology; D018258:Herpesvirus 2, Human / Q000187:drug effects; D006801:Humans; D008297:Male; D010349:Patient Compliance / Q000523:psychology*
D019380:Anti-HIV Agents; D000998:Antiviral Agents; D000212:Acyclovir