Chemistry and pharmacology of collinin, active principle of Zanthoxylum spp.
Collinin is a geranyloxycoumarins isolated in small amounts from plants of the Rutaceae family. Synthetic schemes were recently developed allowing to handle collinin in sufficient quantities to put in evidence valuable biological effects. The aim of this review is to examine the phytochemical and pharmacological properties of this compound.
Epifano
Francesco
F
Dipartimento di Scienze del Farmaco, Università G. D'Annunzio, Chieti Scalo (CH), Italy. fepifano@unich.it
Genovese
Salvatore
S
Marcotullio
Maria Carla
MC
Curini
Massimo
M
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003374:Coumarins / Q000032:analysis / Q000737:chemistry*; D015195:Drug Design; D006801:Humans; D051379:Mice; D008813:Mice, Inbred ICR; D008956:Models, Chemical; D008517:Phytotherapy; D010936:Plant Extracts / Q000032:analysis / Q000737:chemistry*; D011817:Rabbits; D032106:Zanthoxylum / Q000378:metabolism*
D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D003374:Coumarins; D010936:Plant Extracts; C533975:collinin