Metabolomics: a global biochemical approach to the study of central nervous system diseases.
Metabolomics, the omics science of biochemistry, is a global approach to understanding regulation of metabolic pathways and metabolic networks of a biological system. Metabolomics complements data derived from genomics, transcriptomics, and proteomics to assist in providing a systems approach to the study of human health and disease. In this review we focus on applications of metabolomics for the study of diseases of the nervous system. We share concepts in metabolomics, tools used in metabolic profiling and early findings from the study of neuropsychiatric diseases, and drugs used to treat these diseases. Metabolomics emerges as another powerful tool in central nervous system research.
Kaddurah-Daouk
Rima
R
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA. rima.kaddurahdaouk@duke.edu
Krishnan
K Ranga Rama
KR
D000818:Animals; D001689:Biological Psychiatry; D015415:Biomarkers / Q000032:analysis; D002493:Central Nervous System Diseases / Q000378:metabolism*; D006801:Humans; D001523:Mental Disorders / Q000175:diagnosis / Q000378:metabolism; D055432:Metabolomics / Q000379:methods* / Q000639:trends
D015415:Biomarkers