Male-pattern baldness susceptibility locus at 20p11.
We conducted a genome-wide association study for androgenic alopecia in 1,125 men and identified a newly associated locus at chromosome 20p11.22, confirmed in three independent cohorts (n = 1,650; OR = 1.60, P = 1.1 x 10(-14) for rs1160312). The one man in seven who harbors risk alleles at both 20p11.22 and AR (encoding the androgen receptor) has a sevenfold-increased odds of androgenic alopecia (OR = 7.12, P = 3.7 x 10(-15)).
Richards
J Brent
JB
Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Yuan
Xin
X
Geller
Frank
F
Waterworth
Dawn
D
Bataille
Veronique
V
Glass
Daniel
D
Song
Kijoung
K
Waeber
Gerard
G
Vollenweider
Peter
P
Aben
Katja K H
KK
Kiemeney
Lambertus A
LA
Walters
Bragi
B
Soranzo
Nicole
N
Thorsteinsdottir
Unnur
U
Kong
Augustine
A
Rafnar
Thorunn
T
Deloukas
Panos
P
Sulem
Patrick
P
Stefansson
Hreinn
H
Stefansson
Kari
K
Spector
Tim D
TD
Mooser
Vincent
V
D000505:Alopecia / Q000235:genetics*; D002890:Chromosomes, Human, Pair 20 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D015894:Genome, Human / Q000235:genetics; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics