Comparative study of direct-measured and calculated LDL in clinical use.
OBJECTIVE
Compare DLDL-C and CLDL-C obtained during regular service in hospital.


METHODS
The study at Bangkok Hospital included 9,285 lipid profiles of different individuals that contained total cholesterol (TC), triglyceride (TG), HDL cholesterol (HDL-C), and directly-measured (by homogeneous method) LDL cholesterol (DLDL-C). The population has mean age 45.92 +/- 12.43 years, 48% were male. LDL-C values were also calculated by Friedewald equation (CLDL-C). However, it was known to have limitation when TG > 400 mg/dL.


RESULTS
The DLDL-C is 13.4 +/- 8.8% higher than CLDL-C. The authors could obtain CLDL-C closer to DLDL-C in wider TG range, including other explanatory variables in the equation to calculate LDL-C, by these two equations, DLDL-C = 0.98 TC - 0.84 HDL - 0.12 TG + 0.056 age + 0.071 BMI, and DLDL-C = 0.98 (TC- HDL) - 0.12 TG + 0.1 age + 2.4 sex + 0.2 BMI.


CONCLUSIONS
DM and using lipid-lowering medications had no effect on the correlation of CLCL-C and DLDL-C.
Department of Internal Medicine, Bangkok Hospital Medical Center, Bangkok, Thailand. surachrr48@hotmail.com
Surachai
S
Rungtanapirom
Boonsong
B
Ongphiphadhanakul
Thanongsak
T
Kiatbamrungpunt
Jongruck
J
Bhakdikul
Sutep
S
Archavanuntakun
Chaisilp
C
Taerakul
Jantana
J
Pongsanguansin
Veeravit
V
Charoenloet
Krisnapong
K
Tansanguan
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D008076:Cholesterol, HDL / Q000097:blood / Q000187:drug effects; D008078:Cholesterol, LDL / Q000097:blood / Q000187:drug effects*; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides