Efficacy of percutaneous vertebroplasty for multiple synchronous and metachronous vertebral compression fractures.
OBJECTIVE
Limited data exists regarding the efficacy of percutaneous vertebroplasty for multiple synchronous and metachronous vertebral compression fractures. The purpose of this study was to evaluate whether the number of vertebral levels treated during percutaneous vertebroplasty procedures or the number of separate vertebroplasty procedures performed on a given patient affect clinical outcomes.


METHODS
We defined 3 patient populations in our retrospective study. Group 1 included 328 patients who underwent 1 single-level vertebroplasty procedure. Group 2 included 226 patients who underwent a single procedure in which 2 or more vertebral levels were treated. Group 3 included 101 patients who underwent 2 or more separate vertebroplasty procedures. Follow-up was performed between 1 week and 2 years postoperatively. Clinical outcomes were assessed through analysis of quantitative measurements of pre- and postoperative levels of pain with and without activity (0-10) as well as mobility improvement. The Kruskal-Wallis rank sum test was used to evaluate the differences among groups. Univariate and chi(2) analyses were performed to show the proportion of underlying diseases in each group.


RESULTS
Mean pain improvement with/without activity at 2-year follow-up was 5.8/3, 4.9/3.7, and 5.4/3.1 in groups 1, 2, and 3, respectively; and mean mobility improvement in 2-year follow-up was 0.67, 0.63, and 0.65 for groups 1, 2, and 3, respectively.


CONCLUSIONS
There was no significant difference in pain relief and mobility improvement in patients treated for multiple synchronous or metachronous vertebral compression fractures in comparison with those treated for solitary isolated fractures.
Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
L A
LA
Gray
A Ehteshami
AE
Rad
J R
JR
Gaughen
T J
TJ
Kaufmann
D F
DF
Kallmes
D000368:Aged; D000369:Aged, 80 and over; D001416:Back Pain / Q000175:diagnosis; D004185:Disability Evaluation; D005260:Female; D005500:Follow-Up Studies; D050815:Fractures, Compression / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D010149:Postoperative Pain / Q000175:diagnosis; D020127:Recovery of Function; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016103:Spinal Fractures / Q000503:physiopathology / Q000601:surgery*; D016896:Treatment Outcome; D054854:Vertebroplasty / Q000379:methods*