Regulation of potassium (K) handling in the renal collecting duct.
This review provides an overview of the molecular mechanisms of K transport in the mammalian connecting tubule (CNT) and cortical collecting duct (CCD), both nephron segments responsible for the regulation of renal K secretion. Aldosterone and dietary K intake are two of the most important factors regulating K secretion in the CNT and CCD. Recently, angiotensin II (AngII) has also been shown to play a role in the regulation of K secretion. In addition, genetic and molecular biological approaches have further identified new mechanisms by which aldosterone and dietary K intake regulate K transport. Thus, the interaction between serum-glucocorticoid-induced kinase 1 (SGK1) and with-no-lysine kinase 4 (WNK4) plays a significant role in mediating the effect of aldosterone on ROMK (Kir1.1), an important apical K channel modulating K secretion. Recent evidence suggests that WNK1, mitogen-activated protein kinases such as P38, ERK, and Src family protein tyrosine kinase are involved in mediating the effect of low K intake on apical K secretory channels.
Wang
Wen-Hui
WH
Department of Pharmacology, New York Medical College, Valhalla, 10595, USA. wenhui_wang@nymc.edu
Giebisch
Gerhard
G
D000450:Aldosterone / Q000502:physiology; D000804:Angiotensin II / Q000502:physiology; D000818:Animals; D048049:Extracellular Signal-Regulated MAP Kinases / Q000502:physiology; D005768:Gastrointestinal Hormones / Q000502:physiology; D017874:Immediate-Early Proteins / Q000378:metabolism; D007685:Kidney Tubules, Collecting / Q000187:drug effects / Q000378:metabolism*; D045265:Natriuretic Peptides / Q000502:physiology; D011188:Potassium / Q000378:metabolism*; D024661:Potassium Channels, Inwardly Rectifying / Q000502:physiology; D017419:Potassium, Dietary / Q000494:pharmacology*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism / Q000502:physiology; D048051:p38 Mitogen-Activated Protein Kinases / Q000502:physiology; D019061:src-Family Kinases / Q000502:physiology; D000099184:Serum-Glucocorticoid Regulated Kinases
D000450:Aldosterone; D000804:Angiotensin II; D048049:Extracellular Signal-Regulated MAP Kinases; D005768:Gastrointestinal Hormones; D017874:Immediate-Early Proteins; D045265:Natriuretic Peptides; D011188:Potassium; D024661:Potassium Channels, Inwardly Rectifying; D017419:Potassium, Dietary; D017346:Protein Serine-Threonine Kinases; D048051:p38 Mitogen-Activated Protein Kinases; D019061:src-Family Kinases; D000099184:Serum-Glucocorticoid Regulated Kinases; C086989:KCNJ1 protein, human; C072685:guanylin; C084362:uroguanylin; C433806:WNK4 protein, human