Imaging appetite-regulating pathways in the central nervous system using manganese-enhanced magnetic resonance imaging.
The global increase in obesity has led to a redoubling of efforts directed at understanding the control of energy homeostasis. Insight into the mechanisms which govern appetite regulation is central to understanding the pathophysiology of obesity and the design of effective therapeutic interventions. Exploitation of hormonal satiety signals secreted by the gut requires greater insight into their interaction with central nervous system (CNS) circuits of appetite control. Manganese-enhanced magnetic resonance imaging is a novel technique, recently adapted to investigate the effects of gut peptides on CNS appetite circuits. Using manganese ion accumulation as a marker of neuronal activity, changes in signal intensity in key appetite centres within the hypothalamus following peripheral injection of gut hormones have been demonstrated. Manganese-enhanced magnetic resonance imaging offers several advantages over methodologies currently used for the study of gut hormone interactions with the CNS and has the potential for application in fields beyond appetite regulation.
Department of Metabolic Medicine, Imperial College London, Hammersmith Hospital, London, UK.
James R C
JR
Parkinson
Owais B
OB
Chaudhri
Jimmy D
JD
Bell
D000818:Animals; D001069:Appetite Regulation / Q000502:physiology*; D001812:Blood-Brain Barrier; D001931:Brain Mapping / Q000379:methods; D002490:Central Nervous System / Q000378:metabolism* / Q000502:physiology*; D005768:Gastrointestinal Hormones / Q000378:metabolism / Q000502:physiology; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008345:Manganese / Q000008:administration & dosage / Q000378:metabolism*; D009434:Neural Pathways / Q000378:metabolism* / Q000502:physiology*; D013997:Time Factors
D005768:Gastrointestinal Hormones; D008345:Manganese