Quantitative PCR assay used to monitor serum Trichosporon asahii DNA concentrations in disseminated trichosporonosis.
A bone marrow transplant recipient with disseminated trichosporonosis was successfully treated with voriconazole. Quantitative PCR assay results for Trichosporon asahii DNA in the sera were well correlated with the patient's clinical course. Based on the in vitro susceptibility test, the organism was susceptible to voriconazole.
Department of Pediatrics, National Defense Medical College, Tokorozawa, Saitama, Japan. ytsuji@ndmc.ac.jp
Yoichiro
Y
Tsuji
Issei
I
Tokimatsu
Takashi
T
Sugita
Masatoshi
M
Nozaki
Daisuke
D
Kobayashi
Kohsuke
K
Imai
Kazuhiro
K
Kogawa
Shigeaki
S
Nonoyama
D000293:Adolescent; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use; D000946:Antigens, Fungal / Q000097:blood; D016026:Bone Marrow Transplantation; D004271:DNA, Fungal / Q000097:blood*; D006086:Graft vs Host Disease / Q000150:complications; D006801:Humans; D016867:Immunocompromised Host; D007841:Latex Fixation Tests; D008297:Male; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D016133:Polymerase Chain Reaction; D011134:Polysaccharides / Q000097:blood; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications; D011743:Pyrimidines / Q000627:therapeutic use; D014230:Triazoles / Q000627:therapeutic use; D014250:Trichosporon / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D065819:Voriconazole
D000935:Antifungal Agents; D000946:Antigens, Fungal; D004271:DNA, Fungal; D011134:Polysaccharides; D011743:Pyrimidines; D014230:Triazoles; C027478:glucuronoxylomannan; D065819:Voriconazole