Tracheal inflammatory response to bacterial cellulose dressing after surgical scarification in rabbits.
Exuberant scarring tissue formation is among the failure causes of tracheal stenosis surgery. Dressings that could avoid such reaction could be very helpful in these cases. Bacterial cellulose, produced by acetobacter xylinun can be useful in these cases. There are no studies in the laryngotracheal region.


OBJECTIVE
To assess subglottic tissue response in rabbits after scarification and placement of cellulose dressing, and comparing it to a control group.


METHODS
Experimental.


METHODS
26 rabbits underwent laryngotracheal scarification, received the dressing and were compared to the control group. We established four follow up periods. Laryngotracheal specimens underwent histological exam and the results were statistically assessed.


RESULTS
The study group had statistically similar results when compared to the control group in the following parameters: vascular congestion, purulent oozing, acute inflammation, epithelial integrity, fibrous proliferation and granulous proliferation.


CONCLUSIONS
We did not observe differences between the study and control groups as far as inflammation and scarring are concerned. There were no inflammatory signs associated with the use of the cellulose membrane that did no occur because of surgery.
Santa Casa de São Paulo, Maringá, Paraná.
Angelo D'urso
AD
Panerari
Henrique Olival
HO
Costa
Flavia Coelho de
FC
Souza
Marília
M
Castro
Leonardo da
Ld
Silva
Osmar Mesquita de
OM
Sousa Neto
D000818:Animals; D001684:Biological Dressings; D002482:Cellulose / Q000627:therapeutic use*; D005260:Female; D041822:Gluconacetobacter xylinus; D008297:Male; D011817:Rabbits; D011897:Random Allocation; D014132:Trachea / Q000473:pathology* / Q000601:surgery*; D014135:Tracheal Stenosis / Q000473:pathology / Q000517:prevention & control*; D014136:Tracheitis / Q000473:pathology*; D014945:Wound Healing / Q000187:drug effects*
D002482:Cellulose