Modeling the effects of resection, radiation and chemotherapy in glioblastoma.
The standard treatment for newly diagnosed glioblastoma multiforme is surgical resection followed by radiotherapy and chemotherapy. Most studies on these treatments are retrospective clinical data analysis. To integrate these studies, a mathematical model is developed. The model predicts the survival time of patients who undergo resection, radiation, and chemotherapy with different protocols.
Tian
Jianjun Paul
JP
Mathematics Department, The College of William and Mary, Williamsburg, VA, USA. jptian@math.wm.edu
Friedman
Avner
A
Wang
Jin
J
Chiocca
E Antonio
EA
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000628:therapy*; D003131:Combined Modality Therapy / Q000379:methods; D005909:Glioblastoma / Q000628:therapy*; D006801:Humans; D008954:Models, Biological; D019635:Neurosurgical Procedures / Q000379:methods*; D011878:Radiotherapy; D013997:Time Factors
D000970:Antineoplastic Agents