[Systemic lupus erythematosus and pregnancy].
Systemic lupus erythematosus (SLE) is a complex autoimmune disease that predominantly affects women of childbearing age. Prognosis of SLE pregnancy has dramatically improved with the advent in therapeutic management of SLE and in the obstetric care. Consequently, pregnancy is possible in SLE patients when the disease is inactive for at least 6 months. Because of the risk of lupus flare and obstetrical complications (fetal loss, preterm birth, intrauterine growth retardation, preeclampsia), a multidisciplinary approach, associating medical and obstetrical teams, is required. Corticosteroids, hydroxychloroquine and azathioprine are safe in pregnancy and should be kept when necessary.
Service de Médecine Interne, Hôpital Cochin, Université Paris Descartes, Paris, France. veronique.le-guern@cch.aphp.fr
Véronique
V
Le Guern
Emmanuelle
E
Pannier
François
F
Goffinet
D005260:Female; D005313:Fetal Death / Q000209:etiology; D005317:Fetal Growth Retardation / Q000209:etiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000503:physiopathology / Q000517:prevention & control*; D010347:Patient Care Planning; D010348:Patient Care Team; D011225:Pre-Eclampsia / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology / Q000517:prevention & control*; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000209:etiology; D012307:Risk Factors
D007166:Immunosuppressive Agents
Lupus érythémateux systémique et grossesse.