[Studies on pharmacokinetics of artemether patch in mice].
OBJECTIVE
To establish a HPLC-MS-MS determination method of artemether (ARM) and active derivatives DHA, and compare the pharmacokinetic parameters of ARM after transdermal and oral administration.


METHODS
The mice were divided two groups (transdermal and oral) by parallel design. ARM and active derivatives DHA in plasma of mice at different sampling time were determined. The pharmacokinetic parameters were calculated by DAS 2.0 and by statistic analysis.


RESULTS
compare oral administration, the pharmacokinetic parameters of ARM after transdermal, Cmax Tmax , AUC(0-t) MRT, had significant difference (P < 0.05).


CONCLUSIONS
The artemether patch has long-releasing property.
Yang
Hua-sheng
HS
State Research Center for Research and Development of Traditional Chinese Medicine Multi-ingredient Drugs, Beijing 100075, China.
Ye
Zu-guang
ZG
Liang
Bing-wen
BW
Wang
Nai-jie
NJ
He
Cheng
C
Li
Jin-sheng
JS
D000279:Administration, Cutaneous; D000284:Administration, Oral; D000818:Animals; D000077549:Artemether; D037621:Artemisinins / Q000008:administration & dosage* / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D002138:Calibration; D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D012680:Sensitivity and Specificity; D053719:Tandem Mass Spectrometry
D037621:Artemisinins; D004365:Drugs, Chinese Herbal; D000077549:Artemether