A novel report of cig-FISH and cytogenetics in POEMS syndrome.
POEMS syndrome is a plasma cell proliferative disorder whose pathogenesis is poorly understood. We provide the first report of cytoplasmic immunoglobulin/FISH testing (cIg-FISH) in POEMS syndrome using established myeloma markers. We reviewed all 37 POEMS cases seen at our institution in which cIg-FISH testing had been obtained. Monosomy 13 was seen in 14 of the 37 (38%) cIg-FISH samples. One patient had trisomy 3 and 7. Three patients had IgH translocation t(11;14)(q13;q32). No abnormalities were seen at 17p13(p53). The monosomy 13 is in line with other plasma cell disorders while the low prevalence of hyperdiploidy and abnormalities at 14q32 is unique.
Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Alan H
AH
Bryce
Rhett P
RP
Ketterling
Morie A
MA
Gertz
Martha
M
Lacy
Ryan A
RA
Knudson
Shaji
S
Kumar
Robert A
RA
Kyle
Rafael
R
Fonseca
Phillip R
PR
Greipp
John A
JA
Lust
Vincent S
VS
Rajkumar
Suzanne R
SR
Hayman
Francis
F
Buadi
Stephen J
SJ
Russell
Stephen R
SR
Zeldenrust
Angela
A
Dispenzieri
D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics; D015331:Cohort Studies; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D016878:POEMS Syndrome / Q000235:genetics*