Regulation of vitamin D homeostasis: implications for the immune system.
Vitamin D homeostasis in the immune system is the focus of this review. The production of both the activating (25- and 1alpha-hydroxylase) and the metabolizing (24-hydroxylase) enzymes by cells of the immune system itself, indicates that 1,25(OH)(2)D(3) can be produced locally in immune reaction sites. Moreover, the strict regulation of these enzymes by immune signals is highly suggestive for an autocrine/paracrine role in the immune system, and opens new treatment possibilities.
The Laboratory for Experimental Medicine and Endocrinology (LEGENDO), Katholieke Universiteit Leuven , Leuven, Belgium.
Evelyne
E
van Etten
Katinka
K
Stoffels
Conny
C
Gysemans
Chantal
C
Mathieu
Lut
L
Overbergh
D015090:25-Hydroxyvitamin D3 1-alpha-Hydroxylase / Q000378:metabolism*; D002117:Calcitriol / Q000378:metabolism; D004703:Endocrine System / Q000502:physiology*; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects* / Q000502:physiology; D018167:Receptors, Calcitriol / Q000378:metabolism / Q000502:physiology*; D014807:Vitamin D / Q000031:analogs & derivatives / Q000276:immunology / Q000502:physiology
D018167:Receptors, Calcitriol; D014807:Vitamin D; D015090:25-Hydroxyvitamin D3 1-alpha-Hydroxylase; D002117:Calcitriol