Therapeutic potential of type A (I) lantibiotics, a group of cationic peptide antibiotics.
Type A (I) lantibiotics are cationic antimicrobial peptides that have a potential usefulness in treating infectious diseases. They are known to have a potent and broad spectrum of activity, an insignificant cytotoxicity, and demonstrated efficacy in animal infection models, suggesting therapeutic potential. In this review, topics pertaining to their basic structure, mode of bactericidal activity, pharmacology, and methods of manufacture are described.
Mississippi State University, Department of Biological Sciences, Mississippi State, MS 39762, USA. jls859@msstate.edu
Leif
L
Smith
Jd
J
Hillman
D000595:Amino Acid Sequence; D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D001424:Bacterial Infections / Q000188:drug therapy; D001430:Bacteriocins / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D006801:Humans; D008969:Molecular Sequence Data
D000900:Anti-Bacterial Agents; D001430:Bacteriocins