Vincristine induced peripheral neuropathy potentiated by voriconazole in a patient with previously undiagnosed CMT1X.
Peripheral neuropathy is a well-known side effect of vincristine, a micro-tubule inhibitor commonly used to treat malignancies. Severe neurologic adverse events can occur in patients with Charcot-Marie-Tooth disease (CMT) treated with vincristine. Voriconazole is an antifungal agent used increasingly in children with malignancy. Because of its metabolism by hepatic p450 enzymes, voriconazole may inhibit the clearance of many medications, including vincristine. We report a case of vincristine related neuropathy that was exacerbated by voriconazole in a patient with previously undiagnosed, X-linked CMT.
Department of Pediatrics, University of Colorado Denver, Aurora, Colorado.
Christopher C
CC
Porter
Amy E
AE
Carver
Edythe A
EA
Albano
D002607:Charcot-Marie-Tooth Disease / Q000150:complications* / Q000188:drug therapy; D002675:Child, Preschool; D004357:Drug Synergism; D005260:Female; D006801:Humans; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*; D011743:Pyrimidines / Q000009:adverse effects*; D014230:Triazoles / Q000009:adverse effects*; D014750:Vincristine / Q000009:adverse effects*; D065819:Voriconazole
D011743:Pyrimidines; D014230:Triazoles; D014750:Vincristine; D065819:Voriconazole