Investigation of the anti-inflammatory and analgesic effects from an extract of Aplysina caissara, a marine sponge.
A variety of biologically active compounds with pharmacological applications has been reported to occur in marine sponges. The present study was undertaken to provide a set of data about an extract from Aplysina caissara, a Brazilian marine sponge. The antinociceptive and anti-inflammatory effects were investigated against different experimental models in mice. When evaluated against writhing test intraperitoneally (60 and 90 mg/kg), the extract significantly inhibited abdominal constriction by 33.7% and 41.4% respectively. In the formalin test (60 and 90 mg/kg), the extract of sponge inhibited 43.6% and 51.6% in the first phase and 98.2% and 97.2% in the second phase respectively. When evaluated against the hot plate test, both doses demonstrated activity. An increase in the hot plate latency was observed after 60 min. The anti-inflammatory effect was evaluated by formalin-induced mice paw edema. Extract from A. caissara (60 and 90 mg/kg) significantly reduced hind paw swelling. Mortality increased with increasing doses, with LD(50) of 212.2 mg/kg for intraperitoneal administration. These results demonstrated that the extract of the marine sponge A. caissara possesses antinociceptive and anti-edematogenic effects.
Azevedo
Luciana Gutterres
LG
Programa de Pós-Graduação em Ciências Fisiológicas-Fisiologia Animal Comparada, Departamento de Ciências Fisiológicas, Universidade Federal do Rio Grande, av. Itália, km 8, s/n, 96.201-900 Rio Grande, RS, Brazil.
Peraza
Gianni Goulart
GG
Lerner
Clea
C
Soares
Andrea
A
Murcia
Nícolas
N
Muccillo-Baisch
Ana Luiza
AL
D000700:Analgesics / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D018836:Inflammation Mediators / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy / Q000473:pathology; D010147:Pain Measurement / Q000187:drug effects / Q000379:methods; D011161:Porifera
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D018836:Inflammation Mediators