CETP TaqIB polymorphism in Turkish adults: association with dyslipidemia and metabolic syndrome.
OBJECTIVE
In this study, our aim was to investigate the association of cholesterol ester transfer protein (CETP) TaqIB polymorphism with the likelihood of metabolic syndrome (MetS).


METHODS
Study was designed as a cross-sectional analysis of the Turkish Adult Risk Factor follow-up study. Randomly selected sample of 1585 persons were included in the analyses. Genomic DNAs were isolated and the genotyping was performed using TaqMan system. ANOVA, Chi-square, univariate analyses and logistic regression models were used to investigate the association of genotypes with clinical and biochemical measurements.


RESULTS
The frequencies of the B1B1, B1B2 and the B2B2 genotypes were 33.3%, 46.4% and 20.3%, respectively. The B2B2 genotype was associated with elevated high-density lipoprotein -cholesterol (HDL-C) levels (p<0.0001). After adjusting for sex and age B2B2 individuals had 15.9% higher HDL-C levels than B1B1 individuals. Furthermore, the likelihood of dyslipidemia was lower in the presence of the B2B2 genotype (30.9% non-dyslipidemic vs. 69.1% dyslipidemic, p=0.001) when compared to the other genotypes. Moreover, in a logistic regression model comprising age and environmental factors, B1 allele carriers showed higher odds ratios of 1.49 (OR=1.49, 95% CI; 1.03-2.14, p=0.032) for MetS only in females.


CONCLUSIONS
These results suggest that B1 allele is associated with MetS in adult females. However, TaqIB polymorphism appears not associated with the components of MetS other than atherogenic dyslipidemia in adult Turkish population.
Department of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey.
Bilge
B
Ozsait
Evrim
E
Kömürcü Bayrak
Mehveş
M
Poda
Günay
G
Can
Gülay
G
Hergenç
Altan
A
Onat
Steve E
SE
Humphries
Nihan
N
Erginel Unaltuna
D001786:Blood Glucose / Q000378:metabolism; D053480:Cholesterol Ester Transfer Proteins / Q000235:genetics*; D008076:Cholesterol, HDL / Q000097:blood / Q000378:metabolism; D008078:Cholesterol, LDL / Q000097:blood / Q000378:metabolism; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics; D018570:Risk Assessment; D012307:Risk Factors; D012737:Sex Factors; D019914:Taq Polymerase / Q000235:genetics*; D014421:Turkey / Q000453:epidemiology
D001786:Blood Glucose; C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D019914:Taq Polymerase