Anogenital allergic contact dermatitis, the role of spices and flavour allergy.
BACKGROUND
In patients with vulval or anogenital dermatitis, irritant contact dermatitis is more common than allergic contact dermatitis. The reported frequency and relevance of contact sensitivity in anogenital dermatitis varies greatly.


OBJECTIVE
To determine the frequency and relevance of contact sensitization in a Dutch group of female patients with chronic anogenital complaints.


METHODS
We reviewed patch test results of 53 women with chronic anogenital complaints, with sole vulval symptoms in 29 women and sole perianal in 5, in whom inflammatory skin diseases like lichen sclerosus, lichen planus, psoriasis, as well as infectious diseases were unlikely or excluded as a cause of their symptoms. All women were tested with the European baseline series plus additional test series according to their personal history.


RESULTS
Thirty-five patients (66%) showed one or more positive test reactions. Seven of these patients (20%) had one or more clinically relevant positive reactions, most often to flavours and spices.


CONCLUSIONS
A considerable number of patients with anogenital dermatitis have a contact sensitization. Clinically relevant reactions were mainly found to spices and flavours. This is in contrast to the data reported in the literature that shows most contact allergies in vulval patients to ingredients of topical medication.
Vermaat
Hester
H
Department of Dermatology, Vrije Universiteit Medical Centre, Postbus 7057, 1007 MB, Amsterdam, The Netherlands.
Smienk
Fiona
F
Rustemeyer
Thomas
T
Bruynzeel
Derk P
DP
Kirtschig
Gudula
G
D000328:Adult; D000485:Allergens; D001004:Anus Diseases / Q000139:chemically induced* / Q000175:diagnosis* / Q000453:epidemiology; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D005260:Female; D005831:Genital Diseases, Female / Q000139:chemically induced* / Q000175:diagnosis* / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests / Q000379:methods; D015203:Reproducibility of Results; D017365:Spices / Q000633:toxicity*
D000485:Allergens