[Study of hepatitis C virus leukotropism by characterization of viral quasispecies in the liver transplantation setting].
Besides hepatocytes, representing the main replication site of hepatitis C virus, peripheral blood mononuclear cells also represent a crucial target for viral infection. Hepatitis C virus compartmentalization (i.e., non-random distribution) of viral variants between plasma and peripheral blood mononuclear cells, more frequently observed in liver transplant patients compared to non-transplanted patients, makes liver transplantation an interesting model for the analysis of hepatitis C leukotropism. This article aims to present, firstly, in clinical and biological features arguing favour of hepatitis C virus infection leukotropism and, secondly, to review current knowledge about compartmentalization between plasma and peripheral blood mononuclear cells, especially in the liver transplantation setting.
Unité Inserm 748, 3, rue Koeberlé, 67000 Strasbourg, France. schrammfrederic@yahoo.fr
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F
Schramm
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R
Moenne-Loccoz
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S
Fafi-Kremer
E
E
Soulier
C
C
Royer
T
T
Weitten
N
N
Brignon
B
B
Ellero
M-L
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Woehl-Jaegle
C
C
Meyer
P
P
Wolf
M
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Doffoel
T-F
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Baumert
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JP
Gut
F
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Stoll-Keller
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Schvoerer
D001773:Blood Cells / Q000821:virology; D015331:Cohort Studies; D003449:Cryoglobulinemia / Q000821:virology; D016174:Hepacivirus / Q000235:genetics / Q000254:growth & development* / Q000302:isolation & purification / Q000502:physiology; D019698:Hepatitis C, Chronic / Q000150:complications / Q000601:surgery / Q000821:virology; D022781:Hepatocytes / Q000821:virology; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000821:virology*; D008099:Liver / Q000821:virology; D008103:Liver Cirrhosis / Q000209:etiology / Q000601:surgery / Q000821:virology; D016031:Liver Transplantation; D008228:Lymphoma, Non-Hodgkin / Q000821:virology; D009928:Organ Specificity; D018807:Polymorphism, Single-Stranded Conformational; D014759:Viral Envelope Proteins / Q000235:genetics; D014779:Virus Replication
D014759:Viral Envelope Proteins; C091015:glycoprotein E2, Hepatitis C virus
Etude du leucotropisme du virus de l'hépatite C par analyse des quasi-espèces virales dans le contexte de la transplantation hépatique.