Electroacupuncture potentiates the antiallodynic effect of intrathecal neostigmine in a rat model of neuropathic pain.
This study was performed to examine whether electroacupuncture potentiates the neostigmine-induced antiallodynia in neuropathic pain rats. Although intrathecal neostigmine (0.05, 0.1, and 0.3 microg) dose-dependently relieved cold allodynia, 0.3 microg neostigmine caused side effects. The coapplication of 0.1 microg neostigmine and electroacupuncture, however, produced potent antiallodynia, which was parallel to the effect of 0.3 microg neostigmine, without side effects. These results indicate that electroacupuncture can enhance the antiallodynic action of intrathecal neostigmine.
Department of East-West Medicine, Graduate School, Kyung Hee University, Seoul, South Korea.
Ha Neul
HN
Kim
Jung Hyuk
JH
Park
Sun Kwang
SK
Kim
Boram
B
Sun
Sungtae
S
Koo
Sun Mi
SM
Choi
Hyunsu
H
Bae
Byung-Il
BI
Min
D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology* / Q000633:toxicity; D003131:Combined Modality Therapy; D004195:Disease Models, Animal; D015671:Electroacupuncture; D007278:Injections, Spinal; D008297:Male; D009388:Neostigmine / Q000494:pharmacology* / Q000633:toxicity; D009437:Neuralgia / Q000188:drug therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley
D002800:Cholinesterase Inhibitors; D009388:Neostigmine