Nitric oxide and interlukin-6 levels in intellectual disability adults with epilepsy.
Nitric oxide (NO) and interlukin-6 (IL-6) are highly reactive mediators that have been shown to play different roles in a variety of different biological process. The role of NO and IL-6 in the neuropathogenesis of brain seizures is still questionable. In order to evaluate the role of NO and IL-6 in neurological disorders such as seizures, we investigated 19 adults with intellectual disability (ID) who suffer from epilepsy and treated for convulsions. NO metabolites (NOx) and IL-6 levels in serum obtained after night-sleep were significantly high among ID individuals diagnosed with epilepsy versus ID people without epilepsy. These results indicated that NOx and IL-6 may have a pathophysiological role in convulsions. Consequently, we suggest that professionals consider chemical inhibitors that might be helpful against the function of NO and IL-6.
Department of Physical Therapy, Sackler Faculty of Medicine, Stanley, Steyer School of Health Professions, Tel Aviv University, Ramat Aviv 69978, Israel. elie@post.tau.ac.il
Eli
E
Carmeli
Reut
R
Beiker
Mohammed
M
Morad
D000328:Adult; D000368:Aged; D017931:DNA Primers; D004827:Epilepsy / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000097:blood* / Q000150:complications; D015850:Interleukin-6 / Q000097:blood* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*; D012333:RNA, Messenger / Q000235:genetics; D012016:Reference Values; D012112:Residential Facilities; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012640:Seizures / Q000097:blood / Q000150:complications
D017931:DNA Primers; D015850:Interleukin-6; D012333:RNA, Messenger; D009569:Nitric Oxide