Novel diaryl or heterocyclic sulfonamides as antimitotic agents.
The sulfonamides constitute an important class of drugs, which display a variety of activities including antibacterial, anti-carbonic anhydrase, diuretic, hypoglycemic and antithyroid effectiveness. A number of sulfonamides have been reported to be potent anticancer agents, which interact with a wide range of different cellular targets. Among these interesting sulfonamides, the diaryl or heterocyclic sulfonamides have recently emerged as an important class of antimitotic agents against different types of cancer, including multidrug resistant tumors. This review summarizes the recent advances of the diaryl or heterocyclic sulfonamides as novel antimitotic agents.
Department of Chemistry and Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA 30303, USA.
Laixing
L
Hu
Zhuo-rong
ZR
Li
Jian-dong
JD
Jiang
David W
DW
Boykin
D000818:Animals; D050256:Antimitotic Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use
D050256:Antimitotic Agents; D006571:Heterocyclic Compounds; D013449:Sulfonamides