Comparison of efficacy between oral morphine sulphate and diclofenac suppository for analgesia during transrectal ultrasound-guided prostate biopsy.
OBJECTIVE
to prospectively evaluate degree of pain during transrectal ultrasound-guided prostate biopsy after receiving analgesics treatment of oral morphine sulphate compared to suppository sodium diclofenac.


METHODS
the study group comprised 60 consecutive men subjects (median age 67.8 years) undergoing transrectal prostate biopsy. They were randomized into two groups; group 1 received oral analgesic of morphine sulphate 10 mg and group 2 received suppository analgesic of sodium diclofenac 100 mg 1 hour before biopsy. Biopsy was taken using a gun biopsy 18 G needle with total 10 biopsies (5 at each lobe). Immediately after the procedure patients were asked to indicate the degree of pain based on visual analogue scale (VAS) from 0 (no pain) to 10 (unbearable pain) scale.


RESULTS
the mean VAS score was 3.83 in oral morphine sulphate group and 4.10 in sodium diclofenac group. According to subdividing of VAS score, low degree of pain was found in 17 patients (56.7%) of morphine sulphate group and in 14 patients (46.7%) of sodium diclofenac group. There was no statistically significant difference in pain between the two groups (P>0.05).


CONCLUSIONS
oral analgesic of morphine sulphate 10 mg has the same efficacy with sodium diclofenac suppository 100 mg to decrease pain during transrectal prostate biopsy.
Department of Urology, Faculty of Medicine, University of Indonesia-National Central General Hospital, dr. Cipto Mangunkusumo, Jalan Diponegoro no. 71, Jakarta Pusat. hesti92@yahoo.com
Hesti
H
Haswir
Rainy
R
Umbas
D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use*; D000701:Analgesics, Opioid / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D001707:Biopsy, Needle / Q000009:adverse effects* / Q000379:methods; D004008:Diclofenac / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010147:Pain Measurement; D011446:Prospective Studies; D011467:Prostate / Q000000981:diagnostic imaging* / Q000473:pathology; D011469:Prostatic Diseases / Q000175:diagnosis / Q000473:pathology; D012007:Rectum; D013488:Suppositories; D018084:Ultrasonography, Interventional / Q000379:methods
D000700:Analgesics; D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D013488:Suppositories; D004008:Diclofenac; D009020:Morphine