Novel role for the LKB1 pathway in controlling monocarboxylate fuel transporters.
A question preoccupying many researchers is how signal transduction pathways control metabolic processes and energy production. A study by Jang et al. (Jang, C., G. Lee, and J. Chung. 2008. J. Cell Biol. 183:11-17) provides evidence that in Drosophila melanogaster a signaling network controlled by the LKB1 tumor suppressor regulates trafficking of an Sln/dMCT1 monocarboxylate transporter to the plasma membrane. This enables cells to import additional energy sources such as lactate and butyrate, enhancing the repertoire of fuels they can use to power vital activities.
Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK. b.filippi@dundee.ac.uk
Beatrice Maria
BM
Filippi
Dario R
DR
Alessi
D000091162:AMP-Activated Protein Kinase Kinases; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002087:Butyrates / Q000378:metabolism; D016764:Cell Polarity / Q000502:physiology; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000166:cytology / Q000378:metabolism; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism; D008954:Models, Biological; D027501:Monocarboxylic Acid Transporters / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism*; D021381:Protein Transport; D015398:Signal Transduction / Q000502:physiology*; D027981:Symporters / Q000378:metabolism; D000099233:Monocarboxylate Transport Protein 1
D000091162:AMP-Activated Protein Kinase Kinases; D002087:Butyrates; D029721:Drosophila Proteins; D019344:Lactic Acid; D027501:Monocarboxylic Acid Transporters; D011494:Protein Kinases; D027981:Symporters; D000099233:Monocarboxylate Transport Protein 1; C495775:LKB1 protein, Drosophila