Healthy individuals with auditory verbal hallucinations; who are they? Psychiatric assessments of a selected sample of 103 subjects.
Epidemiological studies suggest that auditory verbal hallucinations (AVH) occur in approximately 10%-15% of the general population, of whom only a small proportion has a clinically relevant psychotic disorder. It is unclear whether these hallucinations occur as an isolated phenomenon or if AVH in nonclinical individuals are part of a more general susceptibility to schizophrenia. For this study, 103 healthy individuals with frequent AVH were compared with 60 controls matched for sex, age, and education. All participants were examined by a psychiatrist using standardized diagnostic interviews and questionnaires. The individuals with AVH did not have clinically defined delusions, disorganization, or negative or catatonic symptoms, nor did they meet criteria for cluster A personality disorder. However, their global level of functioning was lower than in the controls and there was a pronounced increase on all subclusters of the Schizotypal Personality Questionnaire (SPQ) and the Peters Delusion Inventory, indicating a general increased schizotypal and delusional tendency in the hallucinating subjects. History of childhood trauma and family history of axis I disorders were also more prevalent in these individuals. We showed that higher SPQ scores, lower education, and higher family loading for psychiatric disorders, but not presence of AVH, were associated with lower global functioning. Our data suggest that AVH in otherwise healthy individuals are not an isolated phenomenon but part of a general vulnerability for schizophrenia.
Neuroscience Division University Medical Center Utrecht, B01.206, Rudolf Magnus School for Neuroscience, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. I.Sommer@umcutrecht.nl
Iris E C
IE
Sommer
Kirstin
K
Daalman
Thomas
T
Rietkerk
Kelly M
KM
Diederen
Steven
S
Bakker
Jaap
J
Wijkstra
Marco P M
MP
Boks
D000328:Adult; D003430:Cross-Sectional Studies; D003702:Delusions / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000523:psychology; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006212:Hallucinations / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000523:psychology*; D006801:Humans; D007406:Interview, Psychological; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D011594:Psychometrics / Q000706:statistics & numerical data; D012016:Reference Values; D012307:Risk Factors; D012569:Schizotypal Personality Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000523:psychology*; D012917:Social Adjustment; D055815:Young Adult