Antimicrobial and antiviral activity of hydrolysable tannins.
Hydrolysable tannins (HTs), secondary metabolites widely distributed in the plant kingdom, are generally multiple esters of gallic acid with glucose. HTs have been shown to be effective antagonists against viruses, bacteria and eukaryotic microorganisms. The present review examines the antimicrobial and antiviral activity of HTs, the mechanism(s) of action, and some structure-activity relationships.
Buzzini
Pietro
P
Department of Applied Biology - Microbiology, University of Perugia, Perugia, Italy. pbuzzini@unipg.it
Arapitsas
Panagiotis
P
Goretti
Marta
M
Branda
Eva
E
Turchetti
Benedetta
B
Pinelli
Patrizia
P
Ieri
F
F
Romani
Annalisa
A
D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D005947:Glucose / Q000737:chemistry; D006868:Hydrolysis; D047348:Hydrolyzable Tannins / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D013634:Tannins / Q000737:chemistry*
D000890:Anti-Infective Agents; D000998:Antiviral Agents; D047348:Hydrolyzable Tannins; D013634:Tannins; D005947:Glucose