[Incidence of posterior subcapsular cataract progression after triamcinolone acetonide administration].
OBJECTIVE
To investigate the incidence of posterior subcapsular cataract after topical administration of triamcinolone acetonide.


METHODS
A retrospective, case-control study was conducted in 44 phakic eyes of 38 paients who underwent administration of triamcinolone acetonide. The mean age was 64 +/- 10.4 (39-89). Only posterior sub-Tenon injection was performed. Evaluation of posterior subcapsular cataract was performed by slit lamp microscopy, and risk factors of the posterior subcapsular cataract progression were studied.


RESULTS
Eight eyes (18%) had posterior subcapsular cataract progression in the 12 months after triamcinolone acetonide injection. Five eyes (11%) required cataract surgery. The mean time to the cataract progression was 8.8 +/- 3.7 months. There was no significant difference in the posterior cataract progression between the frequency of injection, the causes of disease, and the age (p = 0.3806, 0.6561, 0.7470).


CONCLUSIONS
The progression of posterior subcapsular cataract is an important complication in the long-term topical administration of triamcinolone acetonide.
Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, 1-Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya-shi 467-8601, Japan. yoshimura.m@hotmail.co.jp
Masanori
M
Yoshimura
Yoshio
Y
Hirano
Miho
M
Nozaki
Munenori
M
Yoshida
Yuichiro
Y
Ogura
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002386:Cataract / Q000139:chemically induced* / Q000453:epidemiology*; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D015552:Injections, Intralesional; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D014222:Triamcinolone Acetonide / Q000008:administration & dosage* / Q000009:adverse effects*
D005938:Glucocorticoids; D014222:Triamcinolone Acetonide