Role of hyaluronidase in the regulation of hemopoiesis.
We evaluated the possibility of hemopoiesis stimulation with hyaluronidase. The response of the blood system depended on the dose of this enzyme. Functional activity of hemopoietic precursor cells increased under the influence of hyaluronidase in a dose of 20 arb. units, which was accompanied by an increase in the secretion of hemopoietins by adherent myelokaryocytes and elevation of hemopoietic activity in blood plasma. The number of erythrokaryocytes and mature neutrophilic granulocytes in the bone marrow, as well as the count of reticulocytes and neutrophils in the peripheral blood increased under these conditions. Administration of hyaluronidase in a high dose (100 arb. units) led to uncoupling of proliferation and differentiation of hemopoietic precursors and produced no considerably changes in the blood.
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
G N
GN
Zyuz'kov
V V
VV
Zhdanov
A M
AM
Dygai
E D
ED
Gol'dberg
D000818:Animals; D005260:Female; D006410:Hematopoiesis / Q000187:drug effects / Q000502:physiology*; D006821:Hyaluronoglucosaminidase / Q000502:physiology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA
D006821:Hyaluronoglucosaminidase