[Susceptibility of Staphylococcus aureus to new macrolide antibiotics].
A total of 73 isolates of Staphylococcus aureus (26 - MRSA, 47 - MSSA) were tested for their susceptibility to macrolide antibiotics and new derivatives (azalide - azythromycin and ketolide -telithromycin). We observed a high - level resistance of MRSA isolates to all tested antibiotics. Over 96% of isolates were resistant to macrolides and azalides and 92,3% to ketolides. Majority of MSSA isolates (93.6%) demonstrated a high-level susceptibility to telithromycin. Mechanisms of resistance to macrolide antibiotics (34 - MLSB and 1 - MSB) were found among 47,9% Staphylococcus aureus isolates. All of MSSA (100%) and 40% MRSA isolates with induction phenotype of resistance (MLSB(I)) were sensitive to telithromycin. Isolates with constitutive phenotype of resistance (MLSB(K)) were resistant to all of the tested antibiotics.
Sacha
Paweł
P
Zakład Diagnostyki Mikrobiologicznej Akademii Medycznej w Białymstoku. sachpt@amb.edu.pl
Wieczorek
Piotr
P
Jakoniuk
Piotr
P
D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D006801:Humans; D048628:Ketolides / Q000494:pharmacology*; D018942:Macrolides / Q000494:pharmacology*; D016106:Methicillin Resistance / Q000235:genetics; D008826:Microbial Sensitivity Tests; D010641:Phenotype; D013045:Species Specificity; D013211:Staphylococcus aureus / Q000145:classification* / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification
D048628:Ketolides; D018942:Macrolides; C106791:telithromycin
Wrazliwość Staphylococcus aureus na nowe antybiotyki makrolidowe.