CC chemokine receptor 4-positive CD4(+) lymphocytes in peripheral blood increases during maturation in healthy beagles.
In this study, percentages of CCR4(+) cells in peripheral CD4(+) T-lymphocytes were examined with flow cytometry in 46 healthy beagles between 3 months and 7 years of age. The percentage of CCR4(+) cells varied from 9.9% to 33.5%. The mean percentage was significantly lower in the group with ages of less than 1 year than those with ages equal to or more than 1 year (p<0.05), suggesting that maturation might increase the CCR4(+) T-lymphocyte subset. No influence of aging on the percentages was detected among the groups with ages equal to or more than 1 year. The findings are useful for establishing a reference value for the percentage of peripheral CCR4(+)CD4(+) lymphocytes in dogs.
Yasuda
Nobutaka
N
Animal Allergy Clinical Laboratories Inc., Kanagawa, Japan.
Masuda
Kenichi
K
Maeda
Sadatoshi
S
D000367:Age Factors; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism*; D004285:Dogs / Q000097:blood* / Q000276:immunology; D005434:Flow Cytometry; D054398:Receptors, CCR4 / Q000097:blood* / Q000378:metabolism
D054398:Receptors, CCR4