[Experimental advances in mineral metabolism].
One of the most important problems faced by nephrologists is the high degree of cardiovascular mortality in patients on dialysis. This increase in cardiovascular disease has been associated with various factors, but, among them, hyperphosphatemia stands out particularly. The serum phosphate levels considered normal in these patients have gradually decreased in recent years. Therefore, phosphate control in the chronic kidney disease patient has become a challenge that has stimulated basic research in recent years. The aim of the following review is to bring together the most novel results presented in the last year, with emphasis on the methods for control of phosphate absorption, its elimination by the kidneys and vascular calcifications, which are one of the most serious direct consequences of hyperphosphatemia.
Valdivieso
J M
JM
Laboratorio de Investigacion, Hospital Universitario Arnau de Vilanova, IRBLLEIDA, Lleida, Spain.
D000818:Animals; D002114:Calcinosis / Q000209:etiology / Q000517:prevention & control; D002118:Calcium / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control; D002614:Chelating Agents / Q000627:therapeutic use; D015913:Chelation Therapy; D002908:Chronic Disease; D004353:Drug Evaluation, Preclinical; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000502:physiology; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000209:etiology / Q000378:metabolism; D054559:Hyperphosphatemia / Q000188:drug therapy / Q000209:etiology; D007408:Intestinal Absorption; D007668:Kidney / Q000378:metabolism; D007674:Kidney Diseases / Q000097:blood; D007811:Lanthanum / Q000627:therapeutic use; D010758:Phosphorus / Q000378:metabolism*; D050608:Sodium-Phosphate Cotransporter Proteins / Q000502:physiology
D002614:Chelating Agents; D050608:Sodium-Phosphate Cotransporter Proteins; D010758:Phosphorus; C119467:lanthanum carbonate; D005346:Fibroblast Growth Factors; D007811:Lanthanum; D000089703:Fibroblast Growth Factor-23; D002118:Calcium
Avances experimentales en metabolismo mineral.