Intraperitoneal dedifferentiated liposarcoma: a case report.
Dedifferentiated liposarcoma is a variant of liposarcoma with a more aggressive course. Mutations of the p53 gene have been found in different types of soft tissue sarcoma. It is generally accepted that p53 mutations in human malignant tumors are often related to a poor prognosis. In our case, analysis of p53 gene mutation in tumor samples was performed. p53 gene mutation was observed in dedifferentiated tumor tissue samples but not in well-differentiated tumor tissue samples. It has been reported that p53 gene mutation occurs most commonly in the retroperitoneum and rarely in other anatomic locations. Herein we report a case of dedifferentiated liposarcoma located at intraperitoneum.
Karaman
Ali
A
Erzurum State Hospital, Department of Medical Genetics, Erzurum 25240, Turkey. alikaramandr@hotmail.com
Kabalar
Mehmet-Esref
ME
Ozcan
Onder
O
Koca
Timur
T
Binici
Dogan-Nasir
DN
D000005:Abdomen / Q000601:surgery; D004252:DNA Mutational Analysis; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008080:Liposarcoma / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010534:Peritoneal Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D016133:Polymerase Chain Reaction; D018714:Radiotherapy, Adjuvant; D016896:Treatment Outcome; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53