[Effects of nano-selenium on the capability of learning memory and the activity of Se-protein of mice].
OBJECTIVE
To investigate the effects of Nano-Selenium on learning memory capability and activity of two kinds of Se-protein in brain and liver of mice, Na, SeO3 as the controls.


METHODS
The mice were administred two kinds of origin (doses of 1 microgSe/d, 2 microgSe/d, 4 microgSe/d) Se by intra-gastric injection respectively. The learning memory ability of the mice was measured by Y-type maze test. Activities of glutathione peroxidase (GSH-Px) and iodothyronine deiodinase (ID) in brain and liver were also measured.


RESULTS
In comparison with the control groups of Na2 Se03, learning memory abilities were improved and activities of ID and GSH-Px (P < 0.01 or P < 0.05) of brain and liver were increased in Nano-Se treatment groups.


CONCLUSIONS
Nano-Se could improve learning memory ability of mice, and enhance ID and GSH-Px activities of brain and liver in mice.
Dept. of Biologey, Suzhou Science and Technology University, Suzhou 215009, China. qinfenju@126.com
Fenju
F
Qin
Yaxin
Y
Ye
Xuemei
X
Yao
D000818:Animals; D001921:Brain / Q000201:enzymology; D005260:Female; D005979:Glutathione Peroxidase / Q000187:drug effects / Q000378:metabolism*; D007453:Iodide Peroxidase / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D008568:Memory / Q000187:drug effects*; D053768:Metal Nanoparticles; D051379:Mice; D011897:Random Allocation; D012643:Selenium / Q000008:administration & dosage / Q000494:pharmacology*
D007453:Iodide Peroxidase; D005979:Glutathione Peroxidase; D012643:Selenium