Cutaneous gamma-delta T-cell lymphoma arising in the setting of Behcet's disease.
Cutaneous gamma-delta T-cell lymphoma (CGD-TCL) is an uncommon lymphoma composed of a clonal proliferation of mature activated gamma-delta T-cells expressing a cytotoxic phenotype. Malignant lymphoma is rarely associated with Behcet's disease, as only 12 cases have been reported in the literature, including a case of cutaneous T-cell lymphoma. In this report, the authors present a new case of CGD-TCL emerging in the course of Behcet's disease in a 40-year-old man. Diagnosis of CGD-TCL was established based on the combination of clinical, histological, immunophenotypical and molecular findings. Through a review of the current literature, the authors analyse the unique clinicopathological, molecular and immunohistochemical features of this rare cutaneous lymphoma.
Department of Pathology, Hospital "La Rabta", 1007 Bab Saadoun Tunis.
I
I
Chelly
F
F
Limaïem
A
A
Mekni
S
S
Bellil
K
K
Bellil
I B
IB
Ghorbel
S
S
Haouet
M
M
Zitouna
N
N
Kchir
D000328:Adult; D001132:Arm; D001528:Behcet Syndrome / Q000150:complications*; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000150:complications* / Q000473:pathology*; D008297:Male; D012878:Skin Neoplasms / Q000150:complications* / Q000473:pathology*