Adult metabolic syndrome and impaired glucose tolerance are associated with different patterns of BMI gain during infancy: Data from the New Delhi Birth Cohort.
OBJECTIVE
The purpose of this study was to describe patterns of infant, childhood, and adolescent BMI and weight associated with adult metabolic risk factors for cardiovascular disease.


METHODS
We measured waist circumference, blood pressure, glucose, insulin and lipid concentrations, and the prevalence of metabolic syndrome (National Cholesterol Education Program Adult Treatment Panel III definition) in 1,492 men and women aged 26-32 years in Delhi, India, whose weight and height were recorded every 6 months throughout infancy (0-2 years), childhood (2-11 years), and adolescence (11 years-adult).


RESULTS
Men and women with metabolic syndrome (29% overall), any of its component features, or higher (greater than upper quartile) insulin resistance (homeostasis model assessment) had more rapid BMI or weight gain than the rest of the cohort throughout infancy, childhood, and adolescence. Glucose intolerance (impaired glucose tolerance or diabetes) was, like metabolic syndrome, associated with rapid BMI gain in childhood and adolescence but with lower BMI in infancy.


CONCLUSIONS
In this Indian population, patterns of infant BMI and weight gain differed for individuals who developed metabolic syndrome (rapid gain) compared with those who developed glucose intolerance (low infant BMI). Rapid BMI gain during childhood and adolescence was a risk factor for both disorders.
MRC Epidemiology Resource Centre, Southampton, UK. chdf@mrc.soton.ac.uk
Caroline H D
CH
Fall
Harshpal Singh
HS
Sachdev
Clive
C
Osmond
Ramakrishnan
R
Lakshmy
Sushant Dey
SD
Biswas
Dorairaj
D
Prabhakaran
Nikhil
N
Tandon
Siddharth
S
Ramji
K Srinath
KS
Reddy
David J P
DJ
Barker
Santosh K
SK
Bhargava
D000293:Adolescent; D000328:Adult; D001724:Birth Weight; D001827:Body Height; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D018149:Glucose Intolerance / Q000503:physiopathology*; D006801:Humans; D007194:India; D007231:Infant, Newborn; D024821:Metabolic Syndrome / Q000453:epidemiology*; D012307:Risk Factors; D055105:Waist Circumference; D055815:Young Adult