[Successful treatment with 5-fluorouracil and cis-dichlorodiammineplatinum combined with 60Gy of radiation in a case of advanced esophageal cancer complicated with chronic renal failure treated with hemodialysis].
5-Fluorouracil(5-FU)and cis-dichlorodiammineplatinum(CDDP)combined with 60Gy of radiation was administered to a 65-year-old man with advanced esophageal cancer complicated with chronic renal failure treated with hemodialysis(HD). Continuous infusion of 5-FU 680mg/m(2) on Days 1-5 and 8-12, and drip infusion of CDDP 40mg/m(2) on Days 1 and 8 were administered twice with a 5-week interval. The CDDP dosage was reduced to 40% and HD was started 30 minutes after CDDP administration. Concurrent radiotherapy was started on Day 1 at 2Gy/d for 5d/week. The concentration of both free CDDP and total CDDP was measured using the atomic absorption method after the second treatment period. The area under the curve(AUC)of free CDDP was 3.3microg x h/ml. Both Grade 4 anemia and Grade 3 leukopenia were observed, but the renal failure did not progress. All toxicities were tolerable and the CDDP dose reduction and HD method were appropriate for the patient.
Arai
Yoko
Y
Department of Gastroenterology, Saku Central Hospital.
Oyama
Tsuneo
T
Hotta
Kinichi
K
Tomori
Akihisa
A
Miyata
Yoshinori
Y
D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000150:complications / Q000628:therapy*; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008297:Male; D011879:Radiotherapy Dosage; D006435:Renal Dialysis
D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D002945:Cisplatin; D005472:Fluorouracil