[Improvement in screening for colorectal cancer associated with the use of immunochemical faecal occult blood test].
Faecal occult blood tests (FOBT) have been established as the most relevant procedure for colorectal cancer screening in the general average risk population. Immunochemical FOBT consists in monoclonal antibodies reacting with the globin of the haemoglobin. These tests provide higher performances than traditional guaiac tests. They do not need any diet restriction and their analytic sensitivity is higher. An increasing number of papers suggest that their acceptance and clinical performances in the general population are more satisfactory than the guaiac test. The use of automated reading allowed to cut the process price making it similar to the guaiac test. The providing of quantitative measure of haemoglobin allows to choose the positivity threshold associated with the best balance between sensitivity, specificity and positivity rate. Comparative studies conducted in France suggest the use of a positivity threshold allowing an increase in both sensitivity and specificity compared to the guaiac tests.
Cancers & Populations, UFR médecine, CHU de Caen, 14000 Caen, France. guy.launoy@unicaen.fr
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D015179:Colorectal Neoplasms / Q000097:blood* / Q000175:diagnosis*; D005243:Feces / Q000737:chemistry; D006138:Guaiac; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008403:Mass Screening / Q000379:methods; D009780:Occult Blood; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D006138:Guaiac
Les progrès du dépistage du cancer colorectal liés à l'utilisation des nouveaux tests immunologiques de recherche de sang dans les selles.