High prevalence of anxiety and depression in patients with primary open-angle glaucoma.
OBJECTIVE
To assess anxiety and depression in patients with primary open-angle glaucoma (POAG).


METHODS
Multicenter prospective case-control study.


METHODS
Two hundred thirty patients with POAG and 230 sex-matched and age-matched reference subjects with no chronic ocular conditions except cataracts.


METHODS
Anxiety and depression were evaluated using Hospital Anxiety and Depression Scale (HADS) questionnaire, which consists of 2 subscales with ranges of 0 to 21, representing anxiety (HADS-A) and depression (HADS-D).


METHODS
The prevalence of POAG patients with anxiety (a score of more than 10 on the HADS-A) or depression (a score of more than 10 on the HADS-D) was compared with that in the reference subjects. The prevalence of patients with depression was compared between the POAG patients with and without current beta-blocker eye drops.


RESULTS
The prevalence (13.0%) of POAG patients with anxiety was significantly higher (P=0.030) than in the reference subjects (7.0%). The prevalence (10.9%) of POAG patients with depression was significantly higher (P=0.026) than in the reference subjects (5.2%). Between the POAG patients with and without beta-blocker eye-drops, no significant difference (P=0.93) in the prevalence of depression was noted.


CONCLUSIONS
POAG was related to anxiety and depression. No significant relationship between the use of beta-blocker eye-drops and depression was noted.
Mabuchi
Fumihiko
F
Department of Ophthalmology, University of Yamanashi, Yamanashi, Japan. fmabuchi@yamanashi.ac.jp
Yoshimura
Kimio
K
Kashiwagi
Kenji
K
Shioe
Kunihiko
K
Yamagata
Zentaro
Z
Kanba
Shigenobu
S
Iijima
Hiroyuki
H
Tsukahara
Shigeo
S
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000368:Aged; D001008:Anxiety Disorders / Q000453:epidemiology*; D016022:Case-Control Studies; D003866:Depressive Disorder / Q000453:epidemiology*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy / Q000453:epidemiology*; D006801:Humans; D007429:Intraocular Pressure; D007564:Japan / Q000453:epidemiology; D008297:Male; D015995:Prevalence; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D011795:Surveys and Questionnaires; D014792:Visual Acuity
D000319:Adrenergic beta-Antagonists