[The role of microparticles in vascular diseases].
Microparticles (MP) are small cell vesicles that are released by activated or apoptotic cells and that are amenable to quantification in peripheral blood. MP consist of the cytoplasm and the cell membrane of their cell of origin, which allows for their assignment to these cells. By the detection of the respected MP one can conclude to the functional status of the cell of origin. It is known that MP confer specific information between cells and contribute to inflammatory and coagulatory processes. They are detectable in many acute and chronic vascular diseases as a surrogate marker for disease activity but also play a role in the pathophysiology of vascular diseases.
Abteilung für Innere Medizin III, Kardiologie und Angiologie, Medizinische Universitätsklinik, Hugstetter Strasse 55, Freiburg. Philipp.Diehl@uniklinik-freiburg.de
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D001024:Aortic Valve Stenosis / Q000503:physiopathology; D002450:Cell Communication; D002462:Cell Membrane / Q000502:physiology; D003593:Cytoplasm / Q000502:physiology; D004730:Endothelium, Vascular / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D017202:Myocardial Ischemia / Q000503:physiopathology; D010316:Particle Size; D014652:Vascular Diseases / Q000503:physiopathology*; D020246:Venous Thrombosis / Q000503:physiopathology
Die Bedeutung von Mikropartikeln bei vaskulären Erkrankungen.