Carbopol-based gels for nasal delivery of progesterone.
The purpose of this study was to investigate the nasal absorption of progesterone from carbopol-based nasal gels in rabbits. Progesterone nasal gels were prepared by dispersing carbopol 974 (1%, 1.5%, and 2%) in distilled water followed by addition of progesterone/progesterone-beta cyclodextrin complex dissolved in propylene glycol then neutralization. The potential use of beta cyclodextrin (CD) as nasal absorption enhancer by simple addition, as a physical mixture and as a complex with progesterone was investigated. The absolute bioavailability of progesterone from nasal gels in rabbits was studied by estimating the serum progesterone level by competitive solid-phase enzyme immunoassay in comparison to intravenous injection. The carbopol gel formulations produced a significant increase in bioavailability. CD complex promotes the nasal absorption of progesterone from carbopol gels as compared with gels where the CD is added by simple addition and gels which do not contain CD. This method of addition of CD as an inclusion complex in the gels could be considered as a preferred platform in nasal drug administration.
Department of Pharmaceutics, C.L. Baid Metha College of Pharmacy, Thorapakkam, Chennai 600097, India. d_rathnam@vsnl.net
Grace
G
Rathnam
N
N
Narayanan
R
R
Ilavarasan
D000180:Acrylic Resins; D000281:Administration, Intranasal; D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D002152:Calorimetry, Differential Scanning; D004337:Drug Carriers; D005782:Gels; D007124:Immunoenzyme Techniques; D011145:Polyvinyls / Q000008:administration & dosage*; D011374:Progesterone / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D011817:Rabbits; D017550:Spectroscopy, Fourier Transform Infrared; D047392:beta-Cyclodextrins / Q000008:administration & dosage
D000180:Acrylic Resins; D004337:Drug Carriers; D005782:Gels; D011145:Polyvinyls; D047392:beta-Cyclodextrins; C006912:carboxypolymethylene; D011374:Progesterone; C031215:betadex