Effect of prenatal lead exposure on superoxide dismutase activity in the brain and liver of rat fetuses.
Prenatal lead exposure had a damaging effect on Cu/Zn superoxide dismutase activity in the brain and liver of rat fetuses (20 days of gestation). The decrease in Cu/Zn superoxide dismutase activity in the brain and liver of treated fetuses reflects activation of free radical processes and impairment of the antioxidant defense system during prenatal lead exposure.
Uzbekov
M G
MG
Moscow Institute of Psychiatry, Federal Agency for Health Care and Social Development. uzbekovmg@mtu-net.ru
Bubnova
N I
NI
Kulikova
G V
GV
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D005260:Female; D005333:Fetus / Q000187:drug effects; D007854:Lead / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D009566:Nitrates / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000201:enzymology*; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism*
D009566:Nitrates; D007854:Lead; C017461:lead nitrate; D013482:Superoxide Dismutase