A case of glomerulopathy showing podocytic infolding in association with Sjögren's syndrome and primary biliary cirrhosis.
A 49-year-old man was admitted to our hospital with mild proteinuria. Prior to admission, he had been diagnosed as having Sjögren's syndrome in association with primary biliary cirrhosis. Examination of a renal biopsy under light microscopy revealed diffuse and global mesangial cell proliferation and a spike and/or bubbling formation of the glomerular basement membrane (GBM), resembling membranoproliferative glomerulonephritis. In contrast, immunofluorescent studies showed marked immunoglobulin and complement depositions in the mesangial areas; however, only faint granular IgG and IgA deposition was observed along the GBM. Interestingly, electron microscopy revealed that a microtubular structure, derived from podocytes, was present in the GBM. We present a case of glomerulopathy showing podocytic infolding in association with Sjögren's syndrome and primary biliary cirrhosis.
Division of Kidney and Hypertension, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan.
Kentaro
K
Koike
Yasunori
Y
Utsunomiya
Yoriko
Y
Ito
Satori
S
Tokudome
Yoichi
Y
Miyazaki
Takahide
T
Suzuki
Hideo
H
Okonogi
Tetsuya
T
Kawamura
Akio
A
Yamada
Tatsuo
T
Hosoya
Kensuke
K
Joh
D050533:Glomerular Basement Membrane / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000150:complications / Q000473:pathology*; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D050199:Podocytes / Q000473:pathology* / Q000648:ultrastructure; D012859:Sjogren's Syndrome / Q000150:complications / Q000473:pathology*