Design and synthesis of intrinsically cell-penetrating nucleopeptides.
Nucleopeptides, which are constituted of alpha-amino acids bearing nucleobases at their side chains, are able to penetrate into cells and to reach the nucleus without cytotoxic effects.
CNRS, Institut de Biologie Moléculaire et Cellulaire, Laboratoire d'Immunologie et Chimie Thérapeutiques, 15 Rue René Descartes, 67000, Strasbourg, France.
Piero
P
Geotti-Bianchini
Julien
J
Beyrath
Olivier
O
Chaloin
Fernando
F
Formaggio
Alberto
A
Bianco
D000595:Amino Acid Sequence; D002460:Cell Line; D002477:Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D015195:Drug Design; D006801:Humans; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D011687:Purines / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry*
D010455:Peptides; D011687:Purines; D011743:Pyrimidines; C030986:pyrimidine