Metabolic syndrome: from epidemiology to systems biology.
Metabolic syndrome (MetSyn) is a group of metabolic conditions that occur together and promote the development of cardiovascular disease (CVD) and diabetes. Recent genome-wide association studies have identified several novel susceptibility genes for MetSyn traits, and studies in rodent models have provided important molecular insights. However, as yet, only a small fraction of the genetic component is known. Systems-based approaches that integrate genomic, molecular and physiological data are complementing traditional genetic and biochemical approaches to more fully address the complexity of MetSyn.
Department of Medicine and Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA. jlusis@mednet.ucla.edu
Aldons J
AJ
Lusis
Alan D
AD
Attie
Karen
K
Reue
D044127:Epigenesis, Genetic / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation; D023281:Genomics / Q000379:methods; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics*; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000235:genetics*; D012307:Risk Factors; D012737:Sex Factors; D049490:Systems Biology / Q000379:methods*