[Clinicopathologic studies of 13 cases of chronic eosinophilic leukemia].
OBJECTIVE
To investigate the role of bone marrow biopsy (BMB) in diagnosis and differential diagnosis for chronic eosinophilic leukemia (CEL).


METHODS
Clinical and pathological features of thirteen CEL patients were analyzed retrospective. Routine histologic examination was performed on H-G-E, reticulin fiber and toluidine blue stained sections of plastic material emdedded samples of bone marrow biopsies.


RESULTS
(1)The male-to-female ratio was 12:1. The median age was 40 (23-67) years old. They presented as fever, anemia, hemorrhage and so on. Most of organs and tissues were also be involved. (2) Peripheral blood counts characterized by eosinophilia (18.1 +/-16.2) x 10(9)/L, (3) BMB showed eosinophils were predominant components, others such as neutrophils, erythrocytes, megakaryocytes were decrease. Degree of reticular fiber was from (1+) to (3+). (4) Follow-up information was available in only 4 patients, whose conditions were stable.


CONCLUSIONS
Combine with the clinical manifestations of CEL patients, it is important in diagnosis and differential diagnosis for CEL by observing the histomorphology features of bone marrow biopsy carefully.
Department of Pathology, Institute of Hematology and Hospital of Blood Disease, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin, China.
Wei
W
Wang
Hui-shu
HS
Chen
En-bin
EB
Liu
Qing-ying
QY
Yang
Li-huan
LH
Fang
Fu-jun
FJ
Sun
Lin-sheng
LS
Qian
D000328:Adult; D000368:Aged; D001706:Biopsy; D001853:Bone Marrow / Q000276:immunology / Q000473:pathology*; D002908:Chronic Disease / Q000145:classification; D003937:Diagnosis, Differential; D004804:Eosinophils / Q000473:pathology*; D005260:Female; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D007958:Leukocyte Count / Q000379:methods; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D055815:Young Adult