Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.
A genome-wide association (GWA) study with pooled DNA in adult attention-deficit/hyperactivity disorder (ADHD) employing approximately 500K SNP markers identifies novel risk genes and reveals remarkable overlap with findings from recent GWA scans in substance use disorders. Comparison with results from our previously reported high-resolution linkage scan in extended pedigrees confirms several chromosomal loci, including 16q23.1-24.3 which also reached genome-wide significance in a recent meta-analysis of seven linkage studies (Zhou et al. in Am J Med Genet Part B, 2008). The findings provide additional support for a common effect of genes coding for cell adhesion molecules (e.g., CDH13, ASTN2) and regulators of synaptic plasticity (e.g., CTNNA2, KALRN) despite the complex multifactorial etiologies of adult ADHD and addiction vulnerability.
Lesch
Klaus-Peter
KP
ADHD Clinical Research Program, Molecular and Clinical Psychobiology, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstr. 15, 97080, Wuerzburg, Germany. kplesch@mail.uni-wuerzburg.de
Timmesfeld
Nina
N
Renner
Tobias J
TJ
Halperin
Rebecca
R
Röser
Christoph
C
Nguyen
T Trang
TT
Craig
David W
DW
Romanos
Jasmin
J
Heine
Monika
M
Meyer
Jobst
J
Freitag
Christine
C
Warnke
Andreas
A
Romanos
Marcel
M
Schäfer
Helmut
H
Walitza
Susanne
S
Reif
Andreas
A
Stephan
Dietrich A
DA
Jacob
Christian
C
D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D015815:Cell Adhesion Molecules; D002875:Chromosomes / Q000235:genetics; D004247:DNA / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D015894:Genome, Human; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008967:Molecular Biology; D009473:Neuronal Plasticity / Q000502:physiology; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
D015815:Cell Adhesion Molecules; D004247:DNA