Pharmacokinetic and pharmacodynamic study of interaction of Rhodiola rosea SHR-5 extract with warfarin and theophylline in rats.
Significant pharmacokinetic/pharmacodynamic interactions between various herbal products and drugs being substrates of cytochrome P450 have recently been reported. The aim of this study was to determine whether Rhodiola rosea SHR-5 extract interacts with warfarin and theophylline when administered concomitantly. Thus, concomitant treatment of rats with theophylline and SHR-5 did not give rise to significant effects on the pharmacokinetics of theophylline. Simultaneous administration of SHR-5 and warfarin did not alter significantly the pharmacokinetics or the anticoagulant activity of warfarin. It is concluded that SHR-5 might be of value in the treatment of patients with mild or moderate depression, and that its interaction with co-administered drugs is likely to be negligible.
Swedish Herbal Institute Research and Development, Askloster, Sweden. alexander.panossian@shi.se
Alexander
A
Panossian
Areg
A
Hovhannisyan
Hasmik
H
Abrahamyan
Emil
E
Gabrielyan
Georg
G
Wikman
D000818:Animals; D000925:Anticoagulants / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology; D041743:Herb-Drug Interactions; D008297:Male; D010936:Plant Extracts / Q000493:pharmacokinetics* / Q000494:pharmacology; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D029771:Rhodiola / Q000737:chemistry*; D013806:Theophylline / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology; D014859:Warfarin / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology
D000925:Anticoagulants; D010936:Plant Extracts; D014859:Warfarin; D013806:Theophylline