Effect of fluoroquinolones on body temperature of mice.
OBJECTIVE
The purpose of this study was to assess the effect of fluoroquinolones on rectal temperature of infected and non-infected mice.


METHODS
The effect of fluoroquinolone administration on rectal temperature was investigated in a mouse model with and without infection.


RESULTS
Hypothermia was induced by administration of gatifloxacin at doses of 1 and 10 mg/kg in non-infected mice, but not by cefditoren pivoxil. In addition, the rectal temperature was decreased in infected mice administered fluoroquinolones or cephems, a greater decrease being noted in animals receiving the former agents.


CONCLUSIONS
This study shows that fluoroquinolones decrease the rectal temperature of mice regardless of infections.
Department of Microbiology and Infectious Disease, Toho University Faculty of Medicine School of Medicine, Tokyo, Japan. shuichi@med.toho-u.ac.jp
Shuichi
S
Miyazaki
Fumio
F
Ishikawa
Saburo
S
Matsuo
Keizo
K
Yamaguchi
D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D002511:Cephalosporins / Q000494:pharmacology*; D024841:Fluoroquinolones / Q000494:pharmacology*; D000077734:Gatifloxacin; D051379:Mice; D012007:Rectum / Q000502:physiology
D018712:Analgesics, Non-Narcotic; D002511:Cephalosporins; D024841:Fluoroquinolones; C057710:cefditoren pivoxil; D000077734:Gatifloxacin