Placebo-controlled, randomized trial of fluoxetine in the treatment of aggression in male intimate partner abusers.
The objective was to determine the efficacy of treating aggressive behavior in men, with a history of intimate partner abuse, with fluoxetine. Twenty-six men with a history of intimate-partner-abusing behavior entered a randomized, placebo-controlled trial of fluoxetine (20-60 mg by mouth per day). The primary outcome measure was the Aggression score from the overt aggression scale-modified (OAS-M). Fluoxetine-treated patients (n=13) did not differ from placebo-treated patients (n=13) on any key demographic or behavioral variables. Although a significant 'pre-post' reduction in OAS-M Aggression score was noted in all patients, no drug-placebo differences for OAS-M Aggression scores were seen in any analysis. Despite the small sample, these results do not support the hypothesis that treatment with an SSRI is associated with a reduction in aggressive behavior among men with a history of intimate partner abuse.
Lee
Royce
R
Clinical Neuroscience & Psychopharmacology Research Unit, Department of Psychiatry, The University of Chicago, Chicago, Illinois.
Kavoussi
Richard J
RJ
Coccaro
Emil F
EF
D000284:Administration, Oral; D000328:Adult; D000374:Aggression / Q000187:drug effects*; D004311:Double-Blind Method; D005473:Fluoxetine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007175:Impulsive Behavior / Q000188:drug therapy* / Q000523:psychology; D008297:Male; D011569:Psychiatric Status Rating Scales; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D013179:Spouse Abuse / Q000517:prevention & control* / Q000523:psychology; D016896:Treatment Outcome; D055815:Young Adult
D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors