Burn healing is dependent on burn site: a quantitative analysis from a porcine burn model.
This retrospective review examines healing in different sites on a porcine burn model; 24 pairs of burns on 18 pigs from other animal trials were selected for analysis. Each pair of burns was located on the either the cranial or the caudal part of the thoracic ribs region, on the same side of the animal. The burns were 40-50 cm(2) in size and of uniform deep-dermal partial thickness. Caudal burns healed significantly better than cranial burns, demonstrated by earlier closure of wounds, less scar formation and better cosmesis. To our knowledge, this is the first detailed study reporting that burn healing is affected by location on a porcine burn model. We recommend that similar symmetrical burns should be used for future comparative assessments of burn healing.
Department of Paediatrics and Child Health, University of Queensland, Royal Children's Hospital, Brisbane 4029, Australia. x.wang@uq.edu.au
Xue-Qing
XQ
Wang
Pei-Yun
PY
Liu
Margit
M
Kempf
Leila
L
Cuttle
Allen Hong-En
AH
Chang
Michael
M
Wong
Olena
O
Kravchuk
Julie
J
Mill
Roy M
RM
Kimble
D000818:Animals; D002056:Burns / Q000503:physiopathology*; D002921:Cicatrix / Q000503:physiopathology*; D005260:Female; D023421:Models, Animal; D012867:Skin / Q000293:injuries / Q000503:physiopathology*; D013552:Swine; D013898:Thoracic Injuries / Q000503:physiopathology*; D014945:Wound Healing / Q000502:physiology*