New vernocuminosides from the stem barks of Vernonia cumingiana Benth.
Seven new stigmastane-type steroidal glycosides, vernocuminosides A-G (1-7), have been isolated from the stem barks of Vernonia cumingiana Benth. The structural elucidation and stereochemistry determination were achieved by spectroscopic and chemical methods including 1D and 2D NMR ((1)H-(1)H COSY, HSQC, HMBC, and NOE) experiments, especially the employment of Snatzke's method expressed by the induced circular dichroism spectra. Anti-inflammatory activities and cytotoxicities of compounds 1-7 were evaluated.
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education & Institute of Materia Medica, Beijing 100050, People's Republic of China.
Jing
J
Liu
Yunbao
Y
Liu
Yikang
Y
Si
Shishan
S
Yu
Jing
J
Qu
Song
S
Xu
Youcai
Y
Hu
Shuanggang
S
Ma
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005966:Glucuronidase / Q000378:metabolism; D007962:Leukocytes / Q000378:metabolism; D018547:Plant Stems / Q000737:chemistry*; D010972:Platelet Activating Factor / Q000096:biosynthesis; D051381:Rats; D013256:Steroids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D035741:Vernonia / Q000737:chemistry*
D000893:Anti-Inflammatory Agents; D005960:Glucosides; D010972:Platelet Activating Factor; D013256:Steroids; D005966:Glucuronidase