The 769G>A variant of the inhibin-alpha gene in Korean patients with preeclampsia.
OBJECTIVE
Increased inhibin A serum and plasma levels in the second trimester are significantly associated with the development of preeclampsia. The measurement of inhibin A during early pregnancies may be helpful to predict those at risk of this disorder. The purpose of this study was to determine whether the 769G>A variant of the inhibin alpha (INHalpha) gene was associated with preeclampsia.


METHODS
We screened the 769G>A variation in 162 preeclamptic patients and in 202 normal pregnancies. The 769G>A variant of the INHalpha gene was determined by the PCR-based restriction fragment length polymorphism analysis and DNA sequencing.


RESULTS
We found no variation between the normal subjects and the preeclamptic patients.


CONCLUSIONS
The 769G>A variant of the INHalpha gene may be rare in Korean patients with preeclampsia.
The Laboratory of Medical Genetics, Cheil General Hospital and Women's Healthcare Center, Kwandong University School of Medicine, Seoul, Korea.
S Y
SY
Kim
J-H
JH
Lim
J-H
JH
Yang
M-Y
MY
Kim
M-H
MH
Kim
S-Y
SY
Park
H-M
HM
Ryu
D000328:Adult; D001483:Base Sequence; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007265:Inhibins / Q000235:genetics*; D007723:Korea; D008423:Maternal Age; D008969:Molecular Sequence Data; D017354:Point Mutation; D012150:Polymorphism, Restriction Fragment Length; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy
C094377:inhibin-alpha subunit; D007265:Inhibins