OMA-gosh, where's that TAF?
How transcription is silenced in early embryos has long been a mystery. In this issue, Guven-Ozkan et al. (2008) report that transcriptional repression during worm embryogenesis is mediated through sequestration of the general transcription factor TAF-4 and is regulated by mechanisms that orchestrate the transition between maternal and zygotic gene expression.
Section on Developmental and Stem Cell Biology, Joslin Diabetes Center, Department of Pathology, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA 02215, USA. keith.blackwell@joslin.harvard.edu
T Keith
TK
Blackwell
Amy K
AK
Walker
D000818:Animals; D017173:Caenorhabditis elegans / Q000196:embryology* / Q000378:metabolism; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D020868:Gene Silencing; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic; D015053:Zygote / Q000378:metabolism
D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; C440205:OMA-1 protein, C elegans; C532582:TAF-4 protein, C elegans; D014157:Transcription Factors; C473076:oma-2 protein, C elegans