Synthesis and antitubercular activity of ferrocenyl diaminoalcohols and diamines.
A total of 21 ferrocenyl and benzyl diaminoalcohols and diamines were synthesized and evaluated against Mycobacterium tuberculosis H37Rv. Interestingly, ferrocenyl diamines exhibit better activities than ferrocenyl diaminoalcohols.
Université des Sciences et Technologie de Lille, Unité de Catalyse et de Chimie du Solide, UMR CNRS 8181, ENSCL, B.P. 108, 59652 Villeneuve d'Ascq, France.
Dimby
D
Andrianina Ralambomanana
Dorothée
D
Razafimahefa-Ramilison
Andry Clément
AC
Rakotohova
Jeanne
J
Maugein
Lydie
L
Pélinski
D000605:Amino Alcohols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D003959:Diamines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D005296:Ferrous Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013329:Structure-Activity Relationship
D000605:Amino Alcohols; D000995:Antitubercular Agents; D003959:Diamines; D005296:Ferrous Compounds