Feline thyroid carcinoma: diagnosis and response to high-dose radioactive iodine treatment.
This study reports the scintigraphy, histopathology, sole treatment with high-dose radioactive iodine and outcome of eight cases of feline thyroid carcinoma. Scintigraphic findings were variable and in 7/8 cases scintigraphic features could not reliably distinguish whether the thyroid tissue was malignant. Histopathology revealed typical criteria of malignancy in all cases, with mitotic activity described most frequently (7/8 cases), followed by infiltration of local tissues (4/8 cases). Cellular pleomorphism was infrequently observed. Single high-dose (1100MBq I(131)) radioiodine therapy was successful in 6/8 cases, with complete resolution of hyperthyroidism, and was associated with prolonged survival times (181-2381 days). Sole treatment with high-dose radioiodine is a safe and effective treatment for functional thyroid carcinoma. The prognosis for feline thyroid carcinoma successfully treated with radioiodine is good, with extended survival times commonly achieved.
The Feline Centre, Department of Clinical Veterinary Science, Division of Companion Animals, University of Bristol, Langford, Bristol, BS40 5DU, United Kingdom. angie.hibbert@bristol.ac.uk
Angie
A
Hibbert
Tim
T
Gruffydd-Jones
Esther L
EL
Barrett
Michael J
MJ
Day
Andrea M
AM
Harvey
D000818:Animals; D002371:Cat Diseases / Q000175:diagnosis* / Q000209:etiology / Q000532:radiotherapy*; D002415:Cats; D005260:Female; D006980:Hyperthyroidism / Q000209:etiology / Q000662:veterinary; D007457:Iodine Radioisotopes / Q000008:administration & dosage*; D008175:Lung Neoplasms / Q000556:secondary / Q000662:veterinary; D008297:Male; D011877:Radionuclide Imaging / Q000662:veterinary; D011795:Surveys and Questionnaires; D016019:Survival Analysis; D013961:Thyroid Gland / Q000000981:diagnostic imaging* / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000532:radiotherapy / Q000662:veterinary*; D016896:Treatment Outcome; D006113:United Kingdom
D007457:Iodine Radioisotopes