Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.
A genome-wide association (GWA) study with pooled DNA in adult attention-deficit/hyperactivity disorder (ADHD) employing approximately 500K SNP markers identifies novel risk genes and reveals remarkable overlap with findings from recent GWA scans in substance use disorders. Comparison with results from our previously reported high-resolution linkage scan in extended pedigrees confirms several chromosomal loci, including 16q23.1-24.3 which also reached genome-wide significance in a recent meta-analysis of seven linkage studies (Zhou et al. in Am J Med Genet Part B, 2008). The findings provide additional support for a common effect of genes coding for cell adhesion molecules (e.g., CDH13, ASTN2) and regulators of synaptic plasticity (e.g., CTNNA2, KALRN) despite the complex multifactorial etiologies of adult ADHD and addiction vulnerability.
ADHD Clinical Research Program, Molecular and Clinical Psychobiology, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstr. 15, 97080, Wuerzburg, Germany. kplesch@mail.uni-wuerzburg.de
Klaus-Peter
KP
Lesch
Nina
N
Timmesfeld
Tobias J
TJ
Renner
Rebecca
R
Halperin
Christoph
C
Röser
T Trang
TT
Nguyen
David W
DW
Craig
Jasmin
J
Romanos
Monika
M
Heine
Jobst
J
Meyer
Christine
C
Freitag
Andreas
A
Warnke
Marcel
M
Romanos
Helmut
H
Schäfer
Susanne
S
Walitza
Andreas
A
Reif
Dietrich A
DA
Stephan
Christian
C
Jacob
D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D015815:Cell Adhesion Molecules; D002875:Chromosomes / Q000235:genetics; D004247:DNA / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D015894:Genome, Human; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008967:Molecular Biology; D009473:Neuronal Plasticity / Q000502:physiology; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
D015815:Cell Adhesion Molecules; D004247:DNA