Anthropometric and metabolic phenotypes in relation to the ADRA2B deletion/insertion polymorphism in Chinese population.
OBJECTIVE
To investigate whether the ADRA2B D/I polymorphism is associated with anthropometric, metabolic, and blood pressure phenotypes in a Chinese population.


METHODS
In 1306 participants enrolled in the JingNing population study, we measured anthropometry, blood pressure, plasma glucose, and serum lipids, and genotyped the ADRA2B D/I polymorphism. We defined overweight (BMI >or= 25 kg/m2) and obesity (BMI >or= 30 kg/m2) according to the WHO criteria.


RESULTS
Genotype frequencies of the ADRA2B D/I polymorphism were significantly (P=0.02) different between 228 (17.5%) overweight and obese participants and 1078 normal weight participants, but similar between 317 (24.3%) hypertensive participants and 989 normotensive participants. After adjustment for covariates, the ADRA2B DD compared with II homozygotes had significantly (P <or= 0.01) lower BMI (21.9 versus 22.5 kg/m2), waist-to-hip ratio (0.835 versus 0.847), and triceps skinfold thickness (1.18 versus 1.27 cm) and had a significantly lower risk of overweight and obesity (odds ratio 0.52, 95% confidence interval, 0.49-0.54, P=0.0001). Further analyses showed significant (P <or= 0.01) interaction between the ADRA2B D/I polymorphism and physical activity in relation to BMI and waist-to-hip ratio. In physically less active participants [energy expenditure <or=3386 kcal/day (median)], DD compared with II homozygotes had lower BMI, waist-to-hip ratio and risk of overweight and obesity by 0.6 kg/m2, 0.012 and 60.6%, respectively.


CONCLUSIONS
The ADRA2B D allele is associated with a favourable anthropometric and metabolic profile in Chinese population, especially in physically less active participants.
Centre for Epidemiological Studies and Clinical Trials, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Li-Hua
LH
Li
Yan
Y
Li
Yan
Y
Wen
Ji-Guang
JG
Wang
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000886:Anthropometry; D001794:Blood Pressure / Q000235:genetics; D001837:Body Weights and Measures; D002648:Child; D002681:China / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology / Q000235:genetics*; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011159:Population Surveillance; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics* / Q000378:metabolism
C547771:ADRA2B protein, human; D018341:Receptors, Adrenergic, alpha-2