Investigation on the relationship between diabetes mellitus type 2 and cognitive impairment.
OBJECTIVE
The incidence of cognitive impairment is increasing with age; however, little is known about the role of hyperglycemia in cognitive impairment. This study focuses on investigating the relationship between diabetes mellitus type 2 and cognitive impairment.


METHODS
60 diabetic patients, amongst whom, 30 had a well-controlled diabetes status and the other 30 had not. These patients were compared to 60 non-diabetic controls whose age, sex and educational class matched with the individuals of the first group. Patients with important risk factors for cognitive disorders (renal failure, major depressive disorders and psychoactive drug users, cerebrovascular accident history, etc.) were not included in the study. Modified Mini Mental Status examination (mMMSE) was done for all patients by a blinded expert examiner.


RESULTS
Subjects with diabetes (n=60) had lower MMSE score than those without diabetes (P<.01). Diabetes was also associated with increased odds of cognitive decline as determined by MMSE scores (odds ratio=1.9; CI=95%, 1.01-3.6). A significant correlation between duration of disease and cognitive dysfunction was observed, P=0.001. Also, the same correlation was found for quality of diabetes control, P=0.002.


CONCLUSIONS
Diabetes mellitus is associated with lower levels of cognitive function.
Kashan University of Medical Sciences, Department of Internal Medicine, Kashan, Iran.
S A
SA
Ebady
M A
MA
Arami
M H
MH
Shafigh
D000328:Adult; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000523:psychology*; D003955:Diagnostic Tests, Routine; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000150:complications / Q000523:psychology; D015994:Incidence; D008297:Male; D008875:Middle Aged