[DC-SIGNR polymorphisms and its association with HIV-1 infection].
OBJECTIVE
To explore the association of the polymorphism of homologue of dendritic cell-specific intercellular adhesion molecule-3 (ICAM-3) grabbing nonintegrin (DC-SIGN related, DC-SIGNR) gene with the susceptibility to HIV-1 infection.


METHODS
The distribution of the DC-SIGNR variants in the tandem repeat region and their association with HIV-1 infection in a cohort composed of 345 HIV-1 seropositive and 468 high-risk HIV-1 seronegative individuals was examined.


RESULTS
There are 14 genotypes and 5 alleles in the DC-SIGNR repeat regions in the cohort. Although the most common DC-SIGNR allele among Chinese Han population and the Caucasian population is 7, it was found in a higher frequency in the Chinese than in Caucasians (67.1% vs.46.0%, P<0.01). HIV-1 seropositive individuals had a lower frequency of the genotype 7/7 than the high-risk seronegative individuals (38.55% vs. 48.29%, P=0.0057), but a higher frequency of genotype 9/5 (4.35% vs. 1.07%, P=0.0029).


CONCLUSIONS
These results suggest that the tandem-repeat polymorphisms of the DC-SIGNR gene in the Chinese Han population exhibit unique genetic characteristics previously unrecognized in the Caucasian population. Genotype 9/5 seems to be a risk factor for HIV-1 infection in the Chinese population.
Laboratory of AIDS Research, Shenzhen Municipal Hospital of Infectious Diseases, Shenzhen, Guangdong 518020, P.R. China.
Hui
H
Wang
Chunhui
C
Wang
Tiejian
T
Feng
Hua
H
Zhou
Lixiong
L
Li
Feng
F
Wang
Guanglu
G
Zhao
Tuofu
T
Zhu
Boping
B
Zhou
D000328:Adult; D000483:Alleles; D015815:Cell Adhesion Molecules / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015658:HIV Infections / Q000235:genetics* / Q000635:transmission / Q000821:virology; D015497:HIV-1; D006801:Humans; D037181:Lectins, C-Type / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D011956:Receptors, Cell Surface / Q000235:genetics*
C433029:CLEC4M protein, human; D015815:Cell Adhesion Molecules; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface