Gene-environment interplay and the importance of self-control in predicting polydrug use and substance-related problems.
Using the National Longitudinal Study of Adolescent Health (Add Health), the current study applies a general biosocial theoretical model to polydrug use and associated substance-related problems. Along with measures of molecular genetic polymorphisms, neurocognitive skills, self-control, and environmental pathogens a recursive path modeling strategy was used to empirically examine the relations between these biosocial measures and polydrug use, alcohol, and drug-related problems in a subsample of 1136 adolescent males (Mean age=21.96, SD=1.73). Results supported the main predictions of the biosocial model finding significant path coefficients across key constructs. In particular, the role of poor self-regulation was found to be sturdy across path models.
Saint Louis University, St. Louis, MO 63103, United States. mvaughn9@slu.edu
Michael G
MG
Vaughn
Kevin M
KM
Beaver
Matt
M
DeLisi
Brian E
BE
Perron
Lisa
L
Schelbe
D000293:Adolescent; D005838:Genotype; D006801:Humans; D007389:Internal-External Control; D008137:Longitudinal Studies; D008297:Male; D018570:Risk Assessment; D019966:Substance-Related Disorders / Q000235:genetics* / Q000523:psychology; D055815:Young Adult