A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties.
The identification of a selective CDK2, 7, 9 inhibitor 4 with improved permeability is described. Compound 4 exhibits comparable CDK selectivity profile to SNS-032, but shows improved permeability and higher bioavailability in mice.
Medicinal Chemistry, Sunesis Pharmaceuticals, South San Francisco, CA 94080, USA. ichoong2@gmail.com
Ingrid C
IC
Choong
Iana
I
Serafimova
Junfa
J
Fan
David
D
Stockett
Erica
E
Chan
Sravanthi
S
Cheeti
Yafan
Y
Lu
Bruce
B
Fahr
Phuongly
P
Pham
Michelle R
MR
Arkin
Duncan H
DH
Walker
Ute
U
Hoch
D000818:Animals; D001682:Biological Availability; D051379:Mice; D010080:Oxazoles / Q000737:chemistry* / Q000493:pharmacokinetics*; D010539:Permeability; D013844:Thiazoles / Q000737:chemistry* / Q000493:pharmacokinetics*
C484864:N-(5-(((5-(1,1-dimethylethyl)-2-oxazolyl)methyl)thio)-2-thiazolyl)-4-piperidinecarboxamide; D010080:Oxazoles; D013844:Thiazoles