Antispasmodic effect of hydroalcoholic extract of Thymus vulgaris on the guinea-pig ileum.
The effects of Thymus vulgaris hydroalcoholic extract on the contractile responses of the isolated guinea-pig ileum were investigated. Contraction changes in the terminal ileum of guinea pigs were monitored using a force displacement transducer amplifier connected to a physiograph. Thymus vulgaris extract inhibited the contractile responses in a dose-dependent manner and also decreased the amplitude of peristaltic waves. It is concluded that T. vulgaris has an antispasmodic action on guinea pig ileum by decreasing the amplitudes of the muscle contractions during peristalsis. The EC50 was calculated as 1.7 mg mL(-1). In guinea-pig ileum the extract led to an antispasmodic effect, possibly by affecting the anticholinergic and serotoninergic pathways.
Internal Medicine Research Center, Semnan University of Medical Science, Semnan, Iran. amo_babaei@yahoo.com
Mehdi
M
Babaei
Mitra Emmami
ME
Abarghoei
Reza
R
Ansari
Abbas Ali
AA
Vafaei
Abbas Ali
AA
Taherian
Maziar Mohammad
MM
Akhavan
Gafar
G
Toussy
Shahrokh
S
Mousavi
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D010276:Parasympatholytics / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010528:Peristalsis / Q000187:drug effects / Q000502:physiology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D046930:Thymus Plant / Q000737:chemistry*; D014665:Vasodilator Agents / Q000494:pharmacology
D010276:Parasympatholytics; D010936:Plant Extracts; D014665:Vasodilator Agents; D000109:Acetylcholine