The study on the degradation and mineralization mechanism of ion-doped calcium polyphosphate in vitro.
Doping with different trace elements can significantly change the original degradability, mineralization, and biological properties of bone repair material. According to the fundamental research on prepared calcium polyphosphate (CPP) as a bone repair material by our group, this article began further exploration on the effect of doping different trace elements (K, Na, Mg, Zn, Sr) into CPP on its degradability and mineralization soaking in simulated body fluids. The results indicated that doped elements significantly changed the lattice parameters and cell volume of crystal, resulted in different types of crystal defect and surface charge distribution, and consequently changed the original degradability and mineralization of CPP. The conclusion is that doped ions with relatively smaller ionic radius and equivalent positive charge compared with Ca(2+) can greatly promote the degradability and mineralization of CPP, whereas doped ions with equivalent ionic radius and diverse positive charges compared with Ca(2+) provide less contribution on promoting the degradability and mineralization or even counteract.
Song
Wei
W
Department of Biomedical Polymers and Artificial Organs, College of Polymer Science and Engineering, Sichuan University, Chengdu, Sichuan 610065, China.
Tian
Meng
M
Department of Biomedical Polymers and Artificial Organs, College of Polymer Science and Engineering, Sichuan University, Chengdu, Sichuan 610065, China.
Chen
Feng
F
Department of Biomedical Polymers and Artificial Organs, College of Polymer Science and Engineering, Sichuan University, Chengdu, Sichuan 610065, China.
Tian
Yefei
Y
Department of Biomedical Polymers and Artificial Organs, College of Polymer Science and Engineering, Sichuan University, Chengdu, Sichuan 610065, China.
Wan
Changxiu
C
Department of Biomedical Polymers and Artificial Organs, College of Polymer Science and Engineering, Sichuan University, Chengdu, Sichuan 610065, China.
Yu
Xixun
X
Department of Biomedical Polymers and Artificial Organs, College of Polymer Science and Engineering, Sichuan University, Chengdu, Sichuan 610065, China.
D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D018786:Bone Substitutes / Q000737:chemistry / Q000378:metabolism; D002113:Calcification, Physiologic; D002118:Calcium / Q000378:metabolism*; D006801:Humans; D007477:Ions / Q000737:chemistry / Q000378:metabolism; D011122:Polyphosphates / Q000737:chemistry / Q000378:metabolism; D014961:X-Ray Diffraction
D001672:Biocompatible Materials; D018786:Bone Substitutes; D007477:Ions; D011122:Polyphosphates; D002118:Calcium