The meaning of gene positioning.
There is no doubt that genomes are organized nonrandomly in the nucleus of higher eukaryotes. But what is the functional relevance of this nonrandomness? In this Essay, we explore the biological meaning of spatial gene positioning by examining the functional link between the activity of a gene and its radial position in the nucleus.
Takizawa
Takumi
T
National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Meaburn
Karen J
KJ
Misteli
Tom
T
D000818:Animals; D002467:Cell Nucleus / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D045584:Chromosome Positioning; D015870:Gene Expression; D006801:Humans; D009685:Nuclear Envelope / Q000378:metabolism