Discovery of new therapeutic targets by the informational spectrum method.
The field of bioinformatics has become a major part of the drug discovery pipeline playing a key role in improvement and acceleration of this time and money consuming process. Here we review the application of the informational spectrum method (ISM), a virtual spectroscopy method for structure/function analysis of proteins, in identification of functional protein domains representing candidate therapeutic targets for drugs against human immunodeficiency virus (HIV)-1, anthrax, highly pathogenic influenza virus H5N1 and cardiovascular diseases.
Veljkovic
Nevena
N
Center for Multidisciplinary Research, Institute of Nuclear Sciences VINCA, Belgrade, Serbia.
Glisic
Sanja
S
Prljic
Jelena
J
Perovic
Vladimir
V
Botta
Maurizio
M
Veljkovic
Veljko
V
D000595:Amino Acid Sequence; D000881:Anthrax / Q000188:drug therapy; D019380:Anti-HIV Agents / Q000494:pharmacology / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000235:genetics; D019295:Computational Biology / Q000379:methods*; D015195:Drug Design; D005544:Forecasting; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000187:drug effects / Q000302:isolation & purification; D008969:Molecular Sequence Data; D009154:Mutation; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D012307:Risk Factors; D013329:Structure-Activity Relationship
D019380:Anti-HIV Agents; D011506:Proteins