[Drug release of sustained-released tablets of total Puerariae flavones].
OBJECTIVE
To study drug release of sustained-released tablets of total puerariae flavones and investigate the evaluating method of sustained released preparations Chinese material medica sustained-released preparation.


METHODS
Rotating basket method and HPLC were employed to assess the characteristics of multi-component.


RESULTS
Under the selected chromatographic conditions, good HPLC fingerprint of the release of sustained-released tablets of total puerariae flavones were obtained. Through the determination of 8 time-point samples,the release of sustained-released tablet of total puerariae flavones had a well-balanced release behavior.


CONCLUSIONS
The HPLC-UV fingerprint method was simple and reproducible, quality of tablets of total puerariae flavones can be controlled effectively by the method. The method could be applied to evaluate the release of sustained-released tablets of total puerariae flavones.
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100094, China.
Feng
F
Shi
Chun-yan
CY
Zhu
D002851:Chromatography, High Pressure Liquid; D003692:Delayed-Action Preparations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism*; D047309:Flavones / Q000737:chemistry / Q000378:metabolism*; D029908:Pueraria / Q000737:chemistry*; D015203:Reproducibility of Results; D013607:Tablets
D003692:Delayed-Action Preparations; D004365:Drugs, Chinese Herbal; D047309:Flavones; D013607:Tablets