A new indoloditerpene derivative, penijanthine A, isolated from Penicillium janthinellum.
In a screen searching for new bioactive agents, a new indoloditerpene, penijanthine A (1), was isolated from Penicillium janthinellum IFM 55557. The structure of 1 was established on the basis of spectroscopic and chemical investigation, as well as detailed comparison with the spectroscopic and physico-chemical data of paxilline (2), which was isolated along with 1.
Itabashi
Takeshi
T
Faculty of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan.
Hosoe
Tomoo
T
Wakana
Daigo
D
Fukushima
Kazutaka
K
Takizawa
Kayoko
K
Yaguchi
Takashi
T
Okada
Kaoru
K
Takaki
Galba Maria de Campos
GM
Kawai
Ken-ichi
K
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D007211:Indoles / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*
D000935:Antifungal Agents; D004224:Diterpenes; D007211:Indoles; C539511:penijanthine A