Posttransplantation lymphoproliferative disorder involving the central nervous system in liver transplant recipients.
BACKGROUND
Posttransplantation lymphoproliferative disorder (PTLD) involving the central nervous system (CNS) is a rare and serious complication associated with solid organ transplantation. We treated a case of PTLD with CNS involvement in a liver transplant recipient and reviewed the literature.


METHODS
The clinicopathological features of a 53-year-old man were retrospectively analyzed.


RESULTS
Metastasis of the hepatoma was preoperatively considered on the basis of clinical findings. Craniotomy was performed and PTLD was diagnosed pathologically. The patient was treated with antiviral agents, radiation therapy, and chemotherapy; the immunosuppressive medication was reduced. The patient is still alive after follow-up for 14 months.


CONCLUSIONS
Definitive diagnosis of PTLD is only established on the basis of histopathologic evaluation of the tissue. Although there are several ways to manage PTLD with CNS involvement, the prognosis is still poor.
Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Qing-Sheng
QS
Xu
Song
S
Ye
Yong-Qing
YQ
Zhou
Jian-Feng
JF
Sheng
Ke
K
Ye
Shu-Sen
SS
Zheng
D000998:Antiviral Agents / Q000627:therapeutic use; D001706:Biopsy; D006528:Carcinoma, Hepatocellular / Q000601:surgery; D016543:Central Nervous System Neoplasms / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D006261:Headache / Q000209:etiology / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008113:Liver Neoplasms / Q000601:surgery; D016031:Liver Transplantation / Q000009:adverse effects*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D018714:Radiotherapy, Adjuvant; D016896:Treatment Outcome
D000998:Antiviral Agents; D007166:Immunosuppressive Agents