Clastic cells: mineralized tissue resorption in health and disease.
Clastic cells are responsible for mineralized tissue resorption. Bone resorbing cells are called osteoclasts; however, they are able to resorb mineralized dental tissues or calcified cartilage and then they are called odontoclasts and chondroclasts, respectively. They derive from mononuclear precursors of the monocyte-macrophage lineage from hemopoietic tissue, reach target mineralized tissues and degrade them under many different physiologic or pathologic stimuli. Clastic cells play a key role in calcium homeostasis, and participate in skeletal growth, tooth movement, and other physiological and pathological events. They interact tightly with forming cells in bone and dental hard tissues; their unbalance may result in disturbed resorptive activity thus, causing local or systemic diseases.
Arana-Chavez
Victor E
VE
Laboratory of Mineralized Tissue Biology, Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, 05508-900 São Paulo, SP, Brazil. vearana@usp.br
Bradaschia-Correa
Vivian
V
D000818:Animals; D001847:Bone Diseases / Q000473:pathology / Q000503:physiopathology*; D001861:Bone Regeneration; D001862:Bone Resorption; D002113:Calcification, Physiologic / Q000502:physiology*; D002118:Calcium / Q000378:metabolism*; D002454:Cell Differentiation; D019070:Cell Lineage; D006801:Humans; D008264:Macrophages / Q000166:cytology; D009805:Odontogenesis / Q000502:physiology*; D010010:Osteoclasts / Q000473:pathology / Q000502:physiology*; D010012:Osteogenesis / Q000502:physiology; D014070:Tooth / Q000166:cytology / Q000254:growth & development
D002118:Calcium