Critical importance of the nine-membered F ring of ciguatoxin for potent bioactivity: total synthesis and biological evaluation of F-ring-modified analogues.
Inoue
Masayuki
M
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. inoue@mol.f.u-tokyo.ac.jp
Lee
Nayoung
N
Miyazaki
Keisuke
K
Usuki
Toyonobu
T
Matsuoka
Shigeru
S
Hirama
Masahiro
M
D000818:Animals; D001921:Brain; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002922:Ciguatoxins / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D008024:Ligands; D008387:Marine Toxins / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D035964:Oxocins / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013574:Synaptosomes / Q000187:drug effects; D000095702:Polyether Toxins
D002922:Ciguatoxins; D008024:Ligands; D008387:Marine Toxins; D035964:Oxocins; C053342:brevetoxin; D000095702:Polyether Toxins