A hybrid form of cardiac resynchronisation therapy in patients with failing systemic right ventricles.
BACKGROUND
Late systemic right ventricular (RV) dysfunction after atrial redirection surgery is common. Patients may require cardiac transplantation in early adulthood.


METHODS
We undertook cardiac resynchronisation (CRT)/defibrillator therapy in two patients as a bridge to transplantation.


RESULTS
Two males (aged 24, 110 kg and 26 years, 106 kg); having undergone a Mustard procedure for dextro-transposition of the great arteries at 7 and 6 months of age respectively, presented with impaired systemic RV function and New York Heart Association III symptoms. Both patients had dual chamber pacemakers in-situ for sinus bradycardia. Upgrade to CRT was performed by conserving the existing endocardial leads and placement of epicardial electrodes. One demonstrated sustained improvement over a 24 month follow-up period.


CONCLUSIONS
A hybrid CRT strategy is feasible in patients with failing systemic RVs and pre-existent endocardial dual chamber pacemakers. Appropriate patient selection criteria and optimum lead placement, however, still needs further evaluation in this population.
Michael
Kevin A
KA
Wessex Cardiothoracic Centre Cardiothoracic, Southampton University Hospitals NHS Trust, Southampton, UK.
Paisey
John R
JR
Mayosi
Bongani M
BM
Robinson
Stephen
S
Allen
Stuart
S
Sunni
Nadia S
NS
Roberts
Paul R
PR
Morgan
John M
JM
Veldtman
Gruschen R
GR
D000328:Adult; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D004452:Echocardiography; D006801:Humans; D008297:Male; D016896:Treatment Outcome; D018497:Ventricular Dysfunction, Right / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*