Machilin G and four neolignans from young fruits of Magnolia denudata show various degrees of inhibitory activity on nitric oxide (NO) production.
Denudatin A and B, denudadione B, fargesone A and machilin G were isolated from Magnolia denudata. These compounds showed inhibitory effects on nitric oxide (NO) production in the lipopolysaccharide plus interferon-gamma activated-murine macrophage cell line, J774.1. Some but not all of the inhibition of NO production by machilin G, and denudatin A and B was apparently through the decreased expression of the inducible NO synthase (iNOS) gene.
Department of Clinical Pharmacy, Aomori University, Aomori, Japan. noshita@aomori-u.ac.jp
Toshiro
T
Noshita
Shinji
S
Funayama
Tadayoshi
T
Hirakawa
Yumi
Y
Kidachi
Kazuo
K
Ryoyama
D000818:Animals; D002460:Cell Line; D005638:Fruit / Q000737:chemistry* / Q000254:growth & development; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D017705:Lignans / Q000737:chemistry* / Q000145:classification / Q000302:isolation & purification / Q000494:pharmacology*; D031566:Magnolia / Q000737:chemistry* / Q000254:growth & development; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis*; D052247:Nitric Oxide Synthase Type II / Q000235:genetics / Q000378:metabolism
D017705:Lignans; D009569:Nitric Oxide; D052247:Nitric Oxide Synthase Type II