TB database: an integrated platform for tuberculosis research.
The effective control of tuberculosis (TB) has been thwarted by the need for prolonged, complex and potentially toxic drug regimens, by reliance on an inefficient vaccine and by the absence of biomarkers of clinical status. The promise of the genomics era for TB control is substantial, but has been hindered by the lack of a central repository that collects and integrates genomic and experimental data about this organism in a way that can be readily accessed and analyzed. The Tuberculosis Database (TBDB) is an integrated database providing access to TB genomic data and resources, relevant to the discovery and development of TB drugs, vaccines and biomarkers. The current release of TBDB houses genome sequence data and annotations for 28 different Mycobacterium tuberculosis strains and related bacteria. TBDB stores pre- and post-publication gene-expression data from M. tuberculosis and its close relatives. TBDB currently hosts data for nearly 1500 public tuberculosis microarrays and 260 arrays for Streptomyces. In addition, TBDB provides access to a suite of comparative genomics and microarray analysis software. By bringing together M. tuberculosis genome annotation and gene-expression data with a suite of analysis tools, TBDB (http://www.tbdb.org/) provides a unique discovery platform for TB research.
Reddy
T B K
TB
Department of Biochemistry, Stanford University, CA 94305, USA. tbreddy@stanford.edu
Riley
Robert
R
Wymore
Farrell
F
Montgomery
Phillip
P
DeCaprio
Dave
D
Engels
Reinhard
R
Gellesch
Marcel
M
Hubble
Jeremy
J
Jen
Dennis
D
Jin
Heng
H
Koehrsen
Michael
M
Larson
Lisa
L
Mao
Maria
M
Nitzberg
Michael
M
Sisk
Peter
P
Stolte
Christian
C
Weiner
Brian
B
White
Jared
J
Zachariah
Zachariah K
ZK
Sherlock
Gavin
G
Galagan
James E
JE
Ball
Catherine A
CA
Schoolnik
Gary K
GK
D035843:Biomedical Research; D003196:Computer Graphics; D030541:Databases, Genetic; D015870:Gene Expression; D016680:Genome, Bacterial; D023281:Genomics; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000378:metabolism; D018511:Systems Integration; D014376:Tuberculosis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*