Synthesis and antibacterial activities of novel oxazolidinones having cyclic sulfonamide moieties.
The synthesis of a new series of oxazolidinones having cyclic sulfonamide moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents on the oxazolidinone ring was investigated. A particular compound 15g having [1,2,5]thiadiazolidin-1,1-dioxide moiety showed the most potent antibacterial activity.
Kim
Seong Jong
SJ
Life Sciences Research Division, Korea Institute of Science and Technology, Cheongryang, Seoul 130-650, Republic of Korea.
Kim
Seoung Jong
SJ
Jung
Myung-Ho
MH
Yoo
Kyung Ho
KH
Cho
Jung-Hyuck
JH
Oh
Chang-Hyun
CH
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000138:chemical synthesis* / Q000494:pharmacology*; D013449:Sulfonamides / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D013449:Sulfonamides