OMA-gosh, where's that TAF?
How transcription is silenced in early embryos has long been a mystery. In this issue, Guven-Ozkan et al. (2008) report that transcriptional repression during worm embryogenesis is mediated through sequestration of the general transcription factor TAF-4 and is regulated by mechanisms that orchestrate the transition between maternal and zygotic gene expression.
Blackwell
T Keith
TK
Section on Developmental and Stem Cell Biology, Joslin Diabetes Center, Department of Pathology, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA 02215, USA. keith.blackwell@joslin.harvard.edu
Walker
Amy K
AK
D000818:Animals; D017173:Caenorhabditis elegans / Q000196:embryology* / Q000378:metabolism; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D020868:Gene Silencing; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic; D015053:Zygote / Q000378:metabolism
D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; C440205:OMA-1 protein, C elegans; C532582:TAF-4 protein, C elegans; D014157:Transcription Factors; C473076:oma-2 protein, C elegans