Design and synthesis of intrinsically cell-penetrating nucleopeptides.
Nucleopeptides, which are constituted of alpha-amino acids bearing nucleobases at their side chains, are able to penetrate into cells and to reach the nucleus without cytotoxic effects.
Geotti-Bianchini
Piero
P
CNRS, Institut de Biologie Moléculaire et Cellulaire, Laboratoire d'Immunologie et Chimie Thérapeutiques, 15 Rue René Descartes, 67000, Strasbourg, France.
Beyrath
Julien
J
Chaloin
Olivier
O
Formaggio
Fernando
F
Bianco
Alberto
A
D000595:Amino Acid Sequence; D002460:Cell Line; D002477:Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D015195:Drug Design; D006801:Humans; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D011687:Purines / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry*
D010455:Peptides; D011687:Purines; D011743:Pyrimidines; C030986:pyrimidine