Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
Sulforaphane (1), a glucosinolate-derived isothiocyanate found in the cruciferous vegetable broccoli, is considered an anticarcinogenic component. In the present study, the proliferation and apoptosis induction in human lung adenocarcinoma LTEP-A2 cells by 1 was investigated. Compound 1 caused G(2)/M-phase arrest (p < 0.05) and increase of apoptotic cell fraction (p < 0.05) in a time- and dose-dependent manner. Intraperitoneal injection of 1 significantly inhibited growth of LTEP-A2 xenografts in nude mice, and 9 days after tumor cell implantation with 100 mg/kg intraperitoneal injection of 1, the average tumor weights in 1-treated mice was >70% lower than that of the control mice.
Liang
Hao
H
State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, People's Republic of China.
Lai
Baitang
B
Yuan
Qipeng
Q
D000230:Adenocarcinoma / Q000188:drug therapy*; D000077192:Adenocarcinoma of Lung; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D001937:Brassica / Q000737:chemistry*; D002453:Cell Cycle / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D017879:Isothiocyanates; D008175:Lung Neoplasms / Q000188:drug therapy*; D051379:Mice; D013454:Sulfoxides; D013861:Thiocyanates / Q000737:chemistry / Q000494:pharmacology*; D014183:Transplantation, Heterologous
D016588:Anticarcinogenic Agents; D017879:Isothiocyanates; D013454:Sulfoxides; D013861:Thiocyanates; C016766:sulforaphane