Electrospun non-woven nanofibrous hybrid mats based on chitosan and PLA for wound-dressing applications.
Continuous defect-free nanofibers containing chitosan (Ch) or quaternized chitosan (QCh) were successfully prepared by one-step electrospinning of Ch or QCh solutions mixed with poly[(L-lactide)-co-(D,L-lactide)] in common solvent. XPS revealed the surface chemical composition of the bicomponent electrospun mats. Crosslinked Ch- and QCh-containing nanofibers exhibited higher kill rates against bacteria S. aureus and E. coli than the corresponding solvent-cast films. SEM observations showed that hybrid mats were very effective in suppressing the adhesion of pathogenic bacteria S. aureus. The hybrid nanofibers are promising for wound-healing applications.
Ignatova
Milena
M
Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev 103A, 1113 Sofia, Bulgaria.
Manolova
Nevena
N
Markova
Nadya
N
Rashkov
Iliya
I
D001422:Bacterial Adhesion; D001458:Bandages; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D055664:Electrochemical Techniques; D004926:Escherichia coli / Q000378:metabolism; D019344:Lactic Acid / Q000737:chemistry; D008422:Materials Testing; D015394:Molecular Structure; D049329:Nanostructures / Q000737:chemistry*; D011091:Polyesters; D011108:Polymers / Q000737:chemistry; D013211:Staphylococcus aureus / Q000378:metabolism; D013499:Surface Properties; D014945:Wound Healing
D001672:Biocompatible Materials; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D048271:Chitosan