No association of PTPN1 polymorphisms with macronutrient intake and measures of adiposity.
The protein tyrosine phosphatase nonreceptor type1 (PTPN1) gene encodes for the protein tyrosine phosphatase 1B, which suppresses the signaling pathway of leptin. Variations of the PTPN1 gene may lead to changes in leptin sensitivity and thereby influence eating behavior and measures of obesity. This study investigated the association between single-nucleotide polymorphisms (SNPs) of the PTPN1 gene and eating behavior and different measures of obesity, including visceral fat. We used data from a population-based, cross-sectional study of 382 Dutch white men aged 40-80 years. Self-reported macronutrient intake was collected with a food frequency questionnaire. Anthropometrical measurements included BMI, waist and hip circumference, total lean and fat mass measured with dual-energy X-ray absorptiometry, and visceral and subcutaneous fat measured with ultrasound. Associations were studied using linear regression analysis. There were no statistically significant associations of SNPs in the PTPN1 gene with dietary phenotypes or measures of obesity.
Complex Genetics Section, Department of Medical Genetics-DBG, University Medical Center Utrecht, Utrecht, The Netherlands.
Florianne
F
Bauer
N Charlotte
NC
Onland-Moret
Anne G
AG
Niehoff
Clara C
CC
Elbers
Diederick E
DE
Grobbee
Cisca
C
Wijmenga
Yvonne T
YT
van der Schouw
D000273:Adipose Tissue; D050154:Adiposity / Q000235:genetics*; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D004032:Diet; D002149:Energy Intake / Q000235:genetics*; D006801:Humans; D020738:Leptin / Q000378:metabolism*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D009765:Obesity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000235:genetics*; D049629:Waist-Hip Ratio
D020738:Leptin; C516607:PTPN1 protein, human; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1