Pestalazines and pestalamides, bioactive metabolites from the plant pathogenic fungus Pestalotiopsis theae.
Pestalazines A (1) and B (2), two new diketopiperazine heterodimers, and pestalamides A-C (3-5), three new amides, have been isolated from cultures of the plant pathogenic fungus Pestalotiopsis theae. The structures of these compounds were elucidated mainly by NMR spectroscopy. The absolute configurations of 1 and 2 were determined using Marfey's method on their acid hydrolysates and by comparison of their CD spectra with that of a model compound. Compounds 1, 3, and 6 displayed inhibitory effects on HIV-1 replication in C8166 cells. Compound 3 also showed potent antifungal activity against Aspergillus fumigatus.
Key Laboratory of Systematic Mycology & Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, People's Republic of China.
Gang
G
Ding
Lihua
L
Jiang
Liangdong
L
Guo
Xulin
X
Chen
Hua
H
Zhang
Yongsheng
Y
Che
D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D001232:Aspergillus fumigatus / Q000187:drug effects; D028241:Camellia sinensis / Q000382:microbiology; D054659:Diketopiperazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
D019380:Anti-HIV Agents; D054659:Diketopiperazines; D026121:Indole Alkaloids; C567994:pestalazine A; C555617:pestalazine B