Synthesis and antitubercular activity of ferrocenyl diaminoalcohols and diamines.
A total of 21 ferrocenyl and benzyl diaminoalcohols and diamines were synthesized and evaluated against Mycobacterium tuberculosis H37Rv. Interestingly, ferrocenyl diamines exhibit better activities than ferrocenyl diaminoalcohols.
Andrianina Ralambomanana
Dimby
D
Université des Sciences et Technologie de Lille, Unité de Catalyse et de Chimie du Solide, UMR CNRS 8181, ENSCL, B.P. 108, 59652 Villeneuve d'Ascq, France.
Razafimahefa-Ramilison
Dorothée
D
Rakotohova
Andry Clément
AC
Maugein
Jeanne
J
Pélinski
Lydie
L
D000605:Amino Alcohols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D003959:Diamines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D005296:Ferrous Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013329:Structure-Activity Relationship
D000605:Amino Alcohols; D000995:Antitubercular Agents; D003959:Diamines; D005296:Ferrous Compounds