[Association of stroke and different combinations of metabolic syndrome components in Chinese adults].
OBJECTIVE
To analyze the association of stroke and metabolic syndrome as well as its component combinations in Chinese adults.


METHODS
Logistic regression was used to analyze the data, including anthropometric measurement, fasting plasma glucose (FPG), blood lipids, and histories of smoking, drinking, and anamnesis, of 47,414 subjects, 22,305 males and 25,105 females, aged 20-75, obtained from Chinese National Health and Nutrition Survey in 2002.


RESULTS
(1) Blood pressure and waist circumference were the most important factors associated with stroke. Along with the clustering of the risk factors, the subjects became more liable to suffer from stroke. Logistic regression showed that after adjustment for age, sex, smoking status, and LDL-C level, the odd ratio (OR) values of the individuals with one, two, three, and four or more factors were 3.01 (1.89-4.81) ,4.37 (2.72-7.01), 9.20 (5.75-14.73), and 13.09 (7.98-21.49) respectively. (2) The combinations of raised hypertension plus hyperglycemia and low LDL-C and central obesity were the most hazard groups, with the OR values of 16.58 (95% CI 8.78-31.32) for stroke. The OR value for the full metabolic syndrome was 10.79 (95% CI 6.81-17.10). Hypertriglyceridemia was not an independent risk factor of stroke. (3) The relationships of metabolic risk factors and stroke were various among different age groups. Stroke was not related with blood glucose, blood pressure, serum lipids, and obesity in the subjects under 35; in those aged 35-55, diastolic Bp and low HDL-C were most significantly related to stroke; as for those above 55, systolic Bp and waist circumference were most significantly related to stroke.


CONCLUSIONS
Central obesity cored metabolic syndrome is an important risk factor of stroke. Different combinations of the components attribute variously to stroke. In people above middle age, stroke is related to metabolic risk factors.
Center of Endocrinology and Metabolism, China-Japan Friendship Hospital, Beijing 100029, China.
Yao
Y
Wang
Guang-wei
GW
Li
Chong-hua
CH
Yao
Yi-song
YS
Hu
Ling-shi
LS
Kong
D000328:Adult; D000368:Aged; D044466:Asian People / Q000706:statistics & numerical data*; D001786:Blood Glucose / Q000378:metabolism; D050218:Body Fat Distribution; D002681:China / Q000453:epidemiology; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D006801:Humans; D016015:Logistic Models; D008297:Male; D008659:Metabolic Diseases / Q000097:blood / Q000150:complications*; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D015995:Prevalence; D012307:Risk Factors; D020521:Stroke / Q000150:complications / Q000175:diagnosis* / Q000208:ethnology; D013577:Syndrome; D055815:Young Adult
D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D002784:Cholesterol