An expeditious and environmentally friendly synthesis of 3-substituted isocoumarins using microwave irradiation.
A microwave-assisted, environmentally friendly, high-yielding, time-saving synthesis of medicinally important 3-substituted isocoumarins was carried out in a single step by direct condensation of homophthalic acid with aryol and acyl chlorides under solvent-free conditions without any solid support. The synthesised isocoumarins were structurally characterised by microanalysis, 1H NMR, EI, IR and UV.
HEJ Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Pakistan. hassaan2@super.net.pk
Khalid Mohammed
KM
Khan
Sumbul
S
Ahmed
Zulfiqar Ali
ZA
Khan
Mubeen
M
Rani
Shahnaz
S
Perveen
Wolfgang
W
Voelter
D049934:Isocoumarins / Q000138:chemical synthesis* / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D010795:Phthalic Acids / Q000737:chemistry
D049934:Isocoumarins; D010795:Phthalic Acids; C060218:homophthalic acid