Lessons for tuberculosis vaccines from respiratory virus infection.
There is a worldwide epidemic of increasingly drug-resistant TB. Bacillus Calmette-Guérin vaccination provides partial protection against disseminated disease in infants but poor protection against later pulmonary TB. Cell-mediated protection against respiratory virus infections requires the presence of T cells in lung tissues, and the most effective prime-boost immunizations for Mycobacterium tuberculosis also induce lung-resident lymphocytes. These observations need to be taken into account when designing future vaccines against M. tuberculosis.
The University of Oxford, Nuffield Department of Clinical Medicine, Edward Jenner Institute for Vaccine Research, Compton, Berkshire, RG20 7NN, UK. peter.beverley@jenner.ac.uk
Peter Charles Leonard
PC
Beverley
Elma Zaven
EZ
Tchilian
D006801:Humans; D008168:Lung / Q000276:immunology*; D009163:Mycobacterium bovis / Q000276:immunology; D012141:Respiratory Tract Infections / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D032581:Tuberculosis Vaccines / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology
D032581:Tuberculosis Vaccines