Towards novel S-DABOC inhibitors: synthesis, biological investigation, and molecular modeling studies.
A small family of S-DABO cytosine analogs (S-DABOCs) has been synthesized and biologically evaluated as HIV-1 inhibitor both on wild type (wt) and drug-resistant mutants leading to the identification of an interesting compound (5d). Molecular modeling studies have been finally performed in order to rationalize the results.
Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Siena, Via Alcide de Gasperi 2, I-53100 Siena, Italy.
Marco
M
Radi
Lucilla
L
Angeli
Luigi
L
Franchi
Lorenzo
L
Contemori
Giovanni
G
Maga
Alberta
A
Samuele
Samantha
S
Zanoli
Mercedes
M
Armand-Ugon
Emmanuel
E
Gonzalez
Anuska
A
Llano
Jose A
JA
Esté
Maurizio
M
Botta
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D003596:Cytosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular
D019380:Anti-HIV Agents; D003596:Cytosine