Cross-correlogram between rat hippocampal and prefrontal neuronal activities.
We recorded spontaneous multiple unit activities (MUAs) of the hippocampus and prefrontal cortex in urethane-anesthetized rats and analyzed cross-correlograms between these MUAs to investigate the functional connectivity of neuronal activities. Results of these analyses reveal a significant correlation between MUAs in these regions, in which the firing initiated from either hippocampus (type H-P) or prefrontal cortex (type P-H) according to the significant peak of cross-correlograms. Furthermore, the MUA bursts were counted: a significant correlation was found between the peak height of cross-correlograms and MUA burst counts in type H-P, but not type P-H. These results suggest that the correlation between the hippocampus and prefrontal cortex MUAs that are related to the burst firing might reflect functional connectivity.
Department of Physiology, School of Medicine, St Marianna University, Kawasaki, Japan. seitu@marianna-u.ac.jp
Sei-Etsu
SE
Fujiwara
Tatsuo
T
Akema
Yoshinori
Y
Izaki
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001931:Brain Mapping / Q000379:methods; D004594:Electrophysiology / Q000379:methods; D006624:Hippocampus / Q000166:cytology / Q000502:physiology*; D008297:Male; D009415:Nerve Net / Q000166:cytology / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D017397:Prefrontal Cortex / Q000166:cytology / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar