Anthropometric and metabolic phenotypes in relation to the ADRA2B deletion/insertion polymorphism in Chinese population.
OBJECTIVE
To investigate whether the ADRA2B D/I polymorphism is associated with anthropometric, metabolic, and blood pressure phenotypes in a Chinese population.


METHODS
In 1306 participants enrolled in the JingNing population study, we measured anthropometry, blood pressure, plasma glucose, and serum lipids, and genotyped the ADRA2B D/I polymorphism. We defined overweight (BMI >or= 25 kg/m2) and obesity (BMI >or= 30 kg/m2) according to the WHO criteria.


RESULTS
Genotype frequencies of the ADRA2B D/I polymorphism were significantly (P=0.02) different between 228 (17.5%) overweight and obese participants and 1078 normal weight participants, but similar between 317 (24.3%) hypertensive participants and 989 normotensive participants. After adjustment for covariates, the ADRA2B DD compared with II homozygotes had significantly (P <or= 0.01) lower BMI (21.9 versus 22.5 kg/m2), waist-to-hip ratio (0.835 versus 0.847), and triceps skinfold thickness (1.18 versus 1.27 cm) and had a significantly lower risk of overweight and obesity (odds ratio 0.52, 95% confidence interval, 0.49-0.54, P=0.0001). Further analyses showed significant (P <or= 0.01) interaction between the ADRA2B D/I polymorphism and physical activity in relation to BMI and waist-to-hip ratio. In physically less active participants [energy expenditure <or=3386 kcal/day (median)], DD compared with II homozygotes had lower BMI, waist-to-hip ratio and risk of overweight and obesity by 0.6 kg/m2, 0.012 and 60.6%, respectively.


CONCLUSIONS
The ADRA2B D allele is associated with a favourable anthropometric and metabolic profile in Chinese population, especially in physically less active participants.
Li
Li-Hua
LH
Centre for Epidemiological Studies and Clinical Trials, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Li
Yan
Y
Wen
Yan
Y
Wang
Ji-Guang
JG
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000886:Anthropometry; D001794:Blood Pressure / Q000235:genetics; D001837:Body Weights and Measures; D002648:Child; D002681:China / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology / Q000235:genetics*; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011159:Population Surveillance; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics* / Q000378:metabolism
C547771:ADRA2B protein, human; D018341:Receptors, Adrenergic, alpha-2