[Role of the expression of mobile elements sine and the genes directed by RNA polymerase III in the regulation of intracellular processes].
Small non-translated RNA genes directed by RNA polymerase III (class III genes) comprise substantial part of mammal genomes--about 10%. Besides well-known class III genes--5S rRNA, tRNA, 7SL RNA genes, mobile elements SINEs--a number of new RNA polymerase III-directed genes with poorly studied functions was revealed. According to the latest data, different class III genes can have significantly different expression regulation mechanisms. These data support the existence of gene-specific, tissue-specific and cell state-specific (resting, stress, apoptosis) mechanisms for the regulation of these gene transcription. The review is devoted to the consideration of known small non-translated RNA genes, possible mechanisms of their expression regulation (by the example of some SINEs), and the role of their transcription products in the intracellular processes regulation.
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TV
Nikitina
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LI
Tishchenko
D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology*; D012320:RNA Polymerase III / Q000235:genetics / Q000378:metabolism*; D018626:Retroelements / Q000502:physiology*; D014158:Transcription, Genetic / Q000502:physiology*
D018626:Retroelements; D012320:RNA Polymerase III