Structural changes in components of the blood-retina barrier in rat retina during photodamage in alloxan diabetes and their correction with ascovertin.
The outer part of the blood-retina barrier was most sensitive to light exposure (6000 lx, 6 h) during photodamage. It was manifested in hemodynamic disturbances, endothelial dysfunction, and focal death of the pigment epithelium. The photo effects increased during alloxan diabetes. The specific area of open vessels decreased, while the number of thrombotic vessels in the choroid increased. Administration of ascovertin improved hemodynamic parameters of the eye and decreased the specific area of focal damage.
Department of Histology, Embryology, and Cytology, Siberian State Medical University, Tomsk. s_logvinov@mail.ru
S V
SV
Logvinov
M B
MB
Plotnikov
E Yu
EY
Varakuta
A A
AA
Zhdankina
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D001813:Blood-Retinal Barrier / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure*; D003921:Diabetes Mellitus, Experimental / Q000473:pathology*; D008027:Light / Q000009:adverse effects*; D008297:Male; D011794:Quercetin / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D012160:Retina / Q000187:drug effects / Q000528:radiation effects* / Q000648:ultrastructure; D012171:Retinal Vessels / Q000648:ultrastructure
C513231:ascovertin; D011794:Quercetin; D001205:Ascorbic Acid