Serum adiponectin is associated with smoking status in healthy Korean men.
OBJECTIVE
To measure the association between smoking and serum adiponectin, taking into consideration insulin resistance and obesity.


METHODS
The cross-sectional study was carried out in Seoul, Korea in 2006. Waist circumference (WC), body mass index (BMI), and serum adiponectin were measured in 2,500 healthy Korean men. Multiple linear regression models were used to assess the association of smoking status with serum adiponectin level. WC, BMI, and homeostasis model assessment (HOMA) were classified into two groups according to median values.


RESULTS
The mean adiponectin concentrations were 6.6 microg/ml and 7.3 microg/ml in current smokers and non-smokers. After adjusting for age, BMI, and alcohol consumption, mean log adiponectin levels decreased by 0.064 microg/ml in current smokers compared with non-smokers (P = 0.0190). Mean log adiponectin levels also decreased by 0.030 and 0.095 microg/ml in moderate and heavy smokers compared to non-smokers. The relationship between adiponectin and smoking was similar between the high and low insulin resistance, BMI, and WC groups.


CONCLUSIONS
These results suggest that serum adiponectin levels are associated with smoking status. These data also support that lower serum adiponectin concentrations in smokers may not be dependent on insulin resistance status or obesity.
Institute for Health Promotion & Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea.
Jae Woong
JW
Sull
Hee Jin
HJ
Kim
Ji Eun
JE
Yun
Eun Jung
EJ
Park
Grace
G
Kim
Sun Ha
SH
Jee
D052242:Adiponectin / Q000097:blood; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000097:blood / Q000453:epidemiology; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D006262:Health; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000097:blood* / Q000453:epidemiology; D055105:Waist Circumference; D055815:Young Adult
C499918:ADIPOQ protein, human; D052242:Adiponectin; D008076:Cholesterol, HDL