Multi-morphological biodegradable PLGE nanoparticles and their drug release behavior.
A series of amphiphilic tri-block copolymers based on poly(lactide-co-glycolide)-b-poly(ethylene oxide)-b-poly(lactide-co-glycolide) (PLGE) with various segment ratios of PEO/PLGA and segment lengths of PEO were synthesized. Multi-morphological biodegradable nanoparticles - PLGE-NPs were fabricated by an improved emulsion/solvent evaporation technique in the absence of surfactant. By adjusting segment ratio of PLGA/PEO (w/w) and molecular weight of PEO, various morphological and nanoscale sized spheres, elliptic spheres, short rods and threads could be formed. The auto-assembling mechanism of the PLGE-NPs and influencing effectors of composition of the PLGE on morphology of the PLGE-NPs were discussed. The PLGE-NPs were biodegradable, and the factors that affected the degradation rate of the PLGE-NPs were also discussed. By using the amphiphilic PLGE polymer, the biodegradable nanoscale immunosuppressive agent - multi-morphological Cyclosporine (CsA)-loaded PLGE-NPs was fabricated. CsA release behavior of the CsA-loaded PLGE-NPs in vitro was determined, and the effect factors on CsA release behavior of the CsA-loaded PLGE-NPs were discussed.
Zhang
Hanwei
H
BNLMS, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Bei
Jianzhong
J
Wang
Shenguo
S
D001672:Biocompatible Materials / Q000494:pharmacology*; D001673:Biodegradation, Environmental / Q000187:drug effects; D016572:Cyclosporine / Q000494:pharmacology; D016503:Drug Delivery Systems; D019344:Lactic Acid / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008970:Molecular Weight; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D043942:Nanotubes / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry / Q000494:pharmacology; D011100:Polyglycolic Acid / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D013057:Spectrum Analysis; D013997:Time Factors
D001672:Biocompatible Materials; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D011092:Polyethylene Glycols; D016572:Cyclosporine