Open-chain half-bastadins mimic the effects of cyclic bastadins on calcium homeostasis in cultured neurons.
Constraining the catechol aryl ether moiety of bastadins by incorporation into a macrocyle is not necessary in order to mimic the effects of these marine natural products on neuronal calcium homeostasis. Simple, acyclic analogs that embody the 'western' or 'eastern' parts of bastadins were found to evoke comparable responses with bastadin 5.
Medical Research Centre, Polish Academy of Sciences, Pawinskiego 5, 02-106 Warsaw, Poland.
Elzbieta
E
Zieminska
Jerzy W
JW
Lazarewicz
Elias A
EA
Couladouros
Vassilios I
VI
Moutsos
Emmanuel N
EN
Pitsinos
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002478:Cells, Cultured; D003500:Cyclization; D055768:Halogenated Diphenyl Ethers / Q000737:chemistry / Q000494:pharmacology*; D006706:Homeostasis / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D011487:Protein Conformation; D051381:Rats
D055768:Halogenated Diphenyl Ethers; C105188:bastadin 5; D002118:Calcium