Magnetic resonance imaging of renal involvement in genetically studied patients with tuberous sclerosis complex.
OBJECTIVE
To evaluate renal involvement in tuberous sclerosis complex (TSC).


METHODS
A series of 24 TSC patients (19 with genetically demonstrated disease), underwent abdominal 1.0-T MR imaging with axial/coronal T1- and T2-weighted scans, with/without fat saturation. We looked for angiomyolipomas (AMLs) and cysts in 47 kidneys of 24 patients. We evaluated the percentage of parenchymal involvement by manual contouring on the coronal scans in 39 kidneys of 20 patients.


RESULTS
We detected AMLs in 15/24 (63%) patients and in 27/47 (57%) kidneys, cysts in 14/24 (58%) and in 26/47 (55%); respectively. AMLs were found in 2/4 TSC1 and in 11/15 TSC2 patients, cysts were found in 2/4 TSC1 and in 9/15 TSC2 patients. The global renal involvement ranged from 0 to 32% (median, 18%) in TSC1 and from 0 to 100% (median, 39%) in TSC2 patients. A fair correlation (r=.464) was found between patient's age and renal involvement, a good correlation (r=0.655) between renal involvement and creatinine clearance.


CONCLUSIONS
Renal parenchyma of TSC patients can be evaluated with MR imaging. A detectable renal involvement was found in 83% of patients, higher in TSC2 than in TSC1. Renal function seems to correlate with renal involvement quantified with MR imaging.
Department of Radiology, University of Milan School of Medicine, San Paolo Hospital, Via A. di Rudinì 8, Milan, Italy. gpompili@sirm.org
Giovanni
G
Pompili
Salvatore
S
Zirpoli
Chiara
C
Sala
Nicola
N
Flor
Rosa Maria
RM
Alfano
Angela
A
Volpi
Diego
D
Brancaccio
Francesco
F
Sardanelli
Gianpaolo
G
Cornalba
D000293:Adolescent; D000328:Adult; D018207:Angiomyolipoma / Q000150:complications / Q000175:diagnosis* / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000235:genetics*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D014402:Tuberous Sclerosis / Q000150:complications / Q000175:diagnosis* / Q000235:genetics*; D055815:Young Adult