Efforts to develop methods for in vivo evaluation of the native beta-cell mass.
Visualization and quantification of the native beta-cell mass in vivo in humans appear to be important in the study of the natural course of diabetes, and in ongoing trials aimed at preserving beta-cell mass in patients with diabetes. This cannot be done by biopsy sampling, and therefore there is a great need for development of a non-invasive method. This article discusses the principle theoretical requirements for reaching this goal. In addition, it provides an overview of tracer probes, which have been examined as potential beta-cell mass imaging agents in the past. Finally, some future perspectives are discussed.
Medical Department 1, Division of Endocrinology and Metabolism, University Hospital Bergmannsheil, Ruhr-University of Bochum, Germany. Stephan.Schneider@ruhr-uni-bochum.de
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D018528:ATP-Binding Cassette Transporters; D003920:Diabetes Mellitus / Q000000981:diagnostic imaging / Q000473:pathology*; D005069:Evaluation Studies as Topic; D005260:Female; D005462:Fluorine Radioisotopes; D000067757:Glucagon-Like Peptide-1 Receptor; D006801:Humans; D050417:Insulin-Secreting Cells / Q000000981:diagnostic imaging / Q000473:pathology* / Q000502:physiology*; D008297:Male; D008970:Molecular Weight; D049268:Positron-Emission Tomography / Q000379:methods; D024661:Potassium Channels, Inwardly Rectifying; D011955:Receptors, Drug; D018027:Receptors, Glucagon / Q000378:metabolism*; D015203:Reproducibility of Results; D022142:Secretory Vesicles / Q000000981:diagnostic imaging; D064233:Sulfonylurea Receptors; D050493:Vesicular Monoamine Transport Proteins
D018528:ATP-Binding Cassette Transporters; D005462:Fluorine Radioisotopes; C000593833:GLP1R protein, human; D000067757:Glucagon-Like Peptide-1 Receptor; D024661:Potassium Channels, Inwardly Rectifying; D011955:Receptors, Drug; D018027:Receptors, Glucagon; D064233:Sulfonylurea Receptors; D050493:Vesicular Monoamine Transport Proteins