Effects of bisphenol A on breast cancer and its risk factors.
The incidence of breast cancer in Korea has been increasing for the last two decades (1983-2005), and now, breast cancer is ranked the leading cause of cancer in Korean women. Along with other endocrine disrupting chemicals (EDCs), bisphenol A (BPA) has been suspected as a potential risk factor for breast cancer. We studied potential associations between BPA exposure and breast cancer risks in Korean women by performing biomonitoring of BPA among breast cancer patients and controls (N = 167). Blood samples were collected between 1994 and 1997 and kept over 10 years in a freezer under well controlled conditions. The blood BPA levels determined by HPLC/FD, ranged between LOD (0.012 microg/L) and 13.87 microg/L (mean +/- SD, 1.69 +/- 2.57 microg/L; median, 0.043 microg/L). In age-matched subjects (N = 152), there were some associations between BPA levels and risks of breast cancer, such as age at first birth and null parity. However, there were no significant differences in blood BPA levels between the cases and the controls (P = 0.42). Considering interactions between BPA exposure and risks of breast cancer, we suggest further enlarged biomonitoring studies of BPA to provide effective prevention against breast cancer.
Yang
Mihi
M
College of Pharmacy, Sookmyung Women's University, Chungpa-Dong, Yongsan-Gu, Seoul 140-742, Republic of Korea. myang@sm.ac.kr
Ryu
Jae-Ha
JH
Jeon
Raok
R
Kang
Daehee
D
Yoo
Keun-Young
KY
D000328:Adult; D001559:Benzhydryl Compounds; D001943:Breast Neoplasms / Q000209:etiology*; D016022:Case-Control Studies; D004305:Dose-Response Relationship, Drug; D052244:Endocrine Disruptors / Q000097:blood / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010636:Phenols / Q000097:blood / Q000494:pharmacology*; D012307:Risk Factors; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds