[Risk-benefit analysis of 18FDG PET cancer screening].
The benefits of (18)F-fluorodeoxyglucose ((18)FDG) positron emission tomography (PET) cancer screening are expected to include a large population of examinees and are intended for a healthy group. Therefore, we attempted to determine the benefit/risk ratio, estimated risk of radiation exposure, and benefit of cancer detection. We used software that embodied the method of the International Commission on Radiological Protection (ICRP) to calculate the average duration of life of radiation exposure. We calculated the lifesaving person years of benefit to be obtained by (18)FDG PET cancer screening detection. We also calculated the benefit/risk ratio using life-shortening and lifesaving person years. According to age, the benefit/risk ratio was more than 1 at 35-39 years old for males and 30-34 years old for females. (18)FDG PET cancer screening also is effective for examinees older than this. A risk-benefit analysis of (18)FDG-PET/computed tomography (CT) cancer screening will be necessary in the future.
Murano
Takeshi
T
Research Center for Cancer Prevention and Screening, National Cancer Center.
Iinuma
Takeshi
T
Tateno
Yukio
Y
Daisaki
Hiromitsu
H
Tateishi
Ukihide
U
Terauchi
Takashi
T
Kato
Kazuaki
K
Inoue
Tomio
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography; D011829:Radiation Dosage; D018570:Risk Assessment; D012984:Software
D019788:Fluorodeoxyglucose F18