Synthesis and free radical scavenging activity of some new spiropyranocoumarins.
A series of novel spiro-substituted 4-hydroxypyranocoumarins and their corresponding dihydropyrano cis-diols has been synthesized. Among them the spiroadamantylpyranocoumarin and the diols can interact with the stable free radical 1,1-diphenyl-2-picrylhydrazyl and scavenge superoxide anions generated in the xanthine-xanthine oxidase system.
Department of Pharmacy, University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.
Vassiliki
V
Panteleon
Ioannis K
IK
Kostakis
Panagiotis
P
Marakos
Nicole
N
Pouli
Ioanna
I
Andreadou
D002384:Catalysis; D003374:Coumarins / Q000138:chemical synthesis* / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000737:chemistry
D003374:Coumarins; D016166:Free Radical Scavengers; D017382:Reactive Oxygen Species