Effectiveness of vaginal administration of Lactobacillus rhamnosus following conventional metronidazole therapy: how to lower the rate of bacterial vaginosis recurrences.
Eighty-four patients with bacterial vaginosis diagnosed according to Amsel's criteria were randomized to receive either oral metronidazole 500 mg twice a day for seven days, or one vaginal tablet containing freeze-dried Lactobacillus rhamnosus once a week at bedtime for two months starting one week after the last antibiotic administration. Followup was performed at days 30, 90 and 180. Chi-squared analysis showed a significant difference between the two treatment groups at day 90 (P = 0.05). Safe and effective long-term vaginal administration of Lactobacillus rhamnosus appears to be a useful complementary approach in the management of bacterial vaginosis.
Department of Gynaecology, Perinatology and Child Health-Gynaecologic Infections and Cervicovaginal Pathology Unit, University "La Sapienza", Rome, Italy. valentinamarcone@libero.it
Valentina
V
Marcone
Ettore
E
Calzolari
Marco
M
Bertini
D000282:Administration, Intravaginal; D000284:Administration, Oral; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000529:Complementary Therapies; D005260:Female; D006801:Humans; D052201:Lacticaseibacillus rhamnosus; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use*; D019936:Probiotics / Q000008:administration & dosage / Q000627:therapeutic use*; D055502:Secondary Prevention; D016585:Vaginosis, Bacterial / Q000188:drug therapy* / Q000517:prevention & control
D000900:Anti-Bacterial Agents; D008795:Metronidazole