Effect of a successful intensive lifestyle program on insulin sensitivity and glucose tolerance in obese youth.
OBJECTIVE
To evaluate the impact on glucose metabolism of a lifestyle program (the Yale Bright Bodies Program) for obese children.


METHODS
Thirteen Bright Bodies and ten clinic-care control subjects who were part of a large randomized clinical trial had 75-g oral glucose tolerance tests at the beginning and end of the 12-month study.


RESULTS
Bright Bodies subjects had significantly greater decreases in weight, BMI, and body fat than clinic-care subjects, and the Bright Body subjects' changes in body composition were accompanied by marked improvements in insulin sensitivity (P = 0.009) and glucose tolerance (P = 0.04).


CONCLUSIONS
An intensive lifestyle program that successfully reduces body weight and body fat can markedly improve insulin sensitivity and glucose metabolism in obese youth.
Shaw
Melissa
M
Department of Pediatrics, Yale University, New Haven, Connecticut, USA. melissa.m.shaw@yale.edu
Savoye
Mary
M
Cali
Anna
A
Dziura
James
J
Tamborlane
William V
WV
Caprio
Sonia
S
D000273:Adipose Tissue / Q000033:anatomy & histology; D000293:Adolescent; D015992:Body Mass Index; D002648:Child; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D008019:Life Style; D008297:Male; D009765:Obesity / Q000534:rehabilitation*; D015431:Weight Loss
D007328:Insulin