The Val allele of HER-2 codon 655 predicts the progression of oral squamous cell carcinoma.
HER-2 proto-oncogene is important for oral carcinogenesis. HER-2 codon 655 polymorphism, either isoleucine (Ile: ATC) or valine (Val: GTC), was associated with the risk of breast carcinoma. This study investigated the clinicopathological implications of this polymorphism in oral carcinoma. We found that 79% of oral carcinoma patients had A/A (Ile/Ile) genotype and 21% had A/G (Ile/Val) genotype, with a G (Val) allelic frequency of 0.10. Univariate analysis indicated a significantly higher Val allelic frequency in cases having nodal metastasis or tumor recurrence; and Val allele was associated with poorer recurrence-free survival of patients. Multivariate analysis after adjusting confounding factors by logistic regression analysis indicated that patients carrying Val allele had a 8.79- and 4.25-fold higher risk for nodal metastasis and recurrence, respectively. Using Cox proportional hazard model, the risk of tumor recurrence was 3.35-fold higher in patients carrying Val allele. This is the first report demonstrating that the Val allele of HER-2 codon 655 could be an independent predictor for oral carcinoma progression.
Wu
Cheng-Hsien
CH
Oral and Maxillofacial Surgery, Department of Dentistry, Taipei Veterans General Hospital, No. 201, Section 2, Shi-Pai Road, Beitou District, Taipei City 112, Taiwan, ROC.
Tu
Hsi-Feng
HF
Gong
Ning-Rong
NR
Chen
Ya-Wei
YW
Liu
Chung-Ji
CJ
Kao
Shou-Yen
SY
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D003062:Codon; D018450:Disease Progression; D005260:Female; D018734:Genes, erbB-2 / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000235:genetics* / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000235:genetics* / Q000473:pathology; D011110:Polymorphism, Genetic; D000090063:Proto-Oncogene Mas; D012307:Risk Factors; D013624:Taiwan
D003062:Codon; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas