Highly enantio- and diastereoselective mannich reactions of chiral Ni(II) glycinates with amino sulfones. Efficient asymmetric synthesis of aromatic alpha,beta-diamino acids.
This paper describes a practical, enantio- and diastereoselective Mannich reaction between a chiral Ni(II) complex of glycine 1 and alpha-amino sulfones 2, involving the creation of a carbon-carbon bond and two stereogenic centers in a single operation; it represents an attractive route to the synthesis alpha,beta-diamino acids.
Drug Discovery and Design Centre, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Graduate School, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
Jiang
J
Wang
Ting
T
Shi
Guanghui
G
Deng
Hualiang
H
Jiang
Hong
H
Liu
D024322:Amino Acids, Aromatic / Q000138:chemical synthesis*; D005998:Glycine / Q000737:chemistry*; D009532:Nickel; D013237:Stereoisomerism; D013450:Sulfones / Q000737:chemistry*
D024322:Amino Acids, Aromatic; D013450:Sulfones; D009532:Nickel; D005998:Glycine