Mutant C57Bl/Kslepr(db/+) mice as a genetic model of type 2 diabetes mellitus.
The genetic model of diabetes mellitus was studied on mutant C57Bl/KsLepr(db/+) mice. These mice were characterized by high concentrations of glucose and glycosylated hemoglobin in the blood, polyuria, polyphagia, polydipsia, progressive obesity, biphasic morphological changes in insular islets of the pancreas (hyperplasia and atrophy), fatty degeneration of the liver, and hypoplasia of the spleen tissue and lymph nodes. Our results indicate that C57Bl/KsLepr(db/+) mice serve as an adequate model of type 2 diabetes mellitus. This model is suitable for testing of therapeutic methods for type 2 diabetes mellitus.
Research Center of Biomedical Technologies, Russian Academy of Medical Sciences.
O I
OI
Stepanova
N N
NN
Karkischenko
O V
OV
Baranova
T V
TV
Galahova
X X
XX
Semenov
T B
TB
Beskova
E A
EA
Stepanova
A R
AR
Zakir'yanov
N A
NA
Onischenko
D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000473:pathology; D004195:Disease Models, Animal; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D010179:Pancreas / Q000473:pathology; D054411:Receptors, Leptin / Q000235:genetics; D013154:Spleen / Q000473:pathology
D054411:Receptors, Leptin