Cephalosol: an antimicrobial metabolite with an unprecedented skeleton from endophytic Cephalosporium acremonium IFB-E007.
Cephalosol (1), a potent antimicrobial secondary metabolite with a new carbon skeleton, was characterized from the culture of Cephalosporium acremonium IFB-E007 that used to reside as an endophyte in Trachelospermum jasminoides (Apocynaceae). Its structure and absolute configuration were unambiguously determined by spectroscopic and computational approaches.
Zhang
Hua Wei
HW
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China.
Huang
Wu Yang
WY
Chen
Jing Rong
JR
Yan
Wei Zhong
WZ
Xie
Dai Qian
DQ
Tan
Ren Xiang
RX
D000164:Acremonium / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D029062:Apocynaceae / Q000737:chemistry; D002176:Candida albicans / Q000187:drug effects; D003198:Computer Simulation; D004926:Escherichia coli / Q000187:drug effects; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D010936:Plant Extracts / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D011551:Pseudomonas fluorescens / Q000187:drug effects; D012015:Reference Standards; D014249:Trichophyton / Q000187:drug effects
D000890:Anti-Infective Agents; D006575:Heterocyclic Compounds, 3-Ring; D010936:Plant Extracts; C533910:cephalosol