Wound repair capability in EDS fibroblasts can be retrieved by exogenous type V collagen.
Impaired wound healing is a typical clinical hallmark of Ehlers-Danlos Syndrome (EDS). Mutated fibroblasts from EDS patients, which deposit an abnormal extracellular matrix, showed defective migration resulting in a marked delay in wound repair. The migratory capability remarkably improved in the presence of exogenous type V collagen.
Viglio
Simona
S
Department of Biochemistry A. Castellani, University of Pavia, 27100 Pavia, Italy.
Zoppi
Nicoletta
N
Sangalli
Antonella
A
Gallanti
Angelo
A
Barlati
Sergio
S
Mottes
Monica
M
Colombi
Marina
M
Valli
Maurizia
M
D024062:Collagen Type V / Q000627:therapeutic use*; D004535:Ehlers-Danlos Syndrome / Q000188:drug therapy*; D005347:Fibroblasts / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology*
D024062:Collagen Type V