Different genetic effects of interferon regulatory factor 5 (IRF5) polymorphisms on systemic lupus erythematosus in a Korean population.
OBJECTIVE
.In an effort to replicate additional associations of interferon regulatory factor 5 (IRF5) polymorphisms with systemic lupus erythematosus (SLE) in an Asian population, we examined those genetic effects in a Korean SLE cohort.


METHODS
Each IRF5 polymorphism was genotyped in 1565 subjects using the TaqMan method and examined to determine whether it could explain the association with SLE.


RESULTS
Three single-nucleotide polymorphisms (IRF5-15-1, rs2070197, and rs10488631), which showed strong and/or independent association in Caucasian populations, were not polymorphic in our Korean population. Association analysis revealed different genetic effects in Koreans compared with Caucasian populations. In addition, conditional analysis suggested independent genetic effects of 3 variant groups in the Korean population.


CONCLUSIONS
We demonstrate different genetic effects of IRF5 polymorphisms on the risk of SLE according to ethnicity.
Laboratory of Genomic Diversity, Department of Life Science, Sogang University, Seoul, Korea.
Hyoung Doo
HD
Shin
Il
I
Kim
Chan-Bum
CB
Choi
Soo Ok
SO
Lee
Hye Won
HW
Lee
Sang-Cheol
SC
Bae
D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics* / Q000706:statistics & numerical data; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology; D005838:Genotype; D006801:Humans; D050835:Interferon Regulatory Factors / Q000235:genetics*; D007723:Korea / Q000453:epidemiology; D015810:Linkage Disequilibrium; D008180:Lupus Erythematosus, Systemic / Q000208:ethnology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D055815:Young Adult
C431713:IRF5 protein, human; D050835:Interferon Regulatory Factors