[Chronic viral C hepatitis associated with primary biliary cirrhosis. Report of two cases].
Chronic viral hepatitis C is often associated with various autoimmune disorders. We report two patients infected by genotype 1b hepatitis C virus associated with primary biliary cirrhosis. These patients had anicteric cholestasis associated with cytolysis and positivity of M2 antimitochondrial antibodies at a titre of 1/200. Liver biopsy revealed chronic hepatitis in one case and histological pattern of primary biliary cirrhosis in the other. One patient was treated by antiviral therapy; the other only by ursodesoxycholic acid because of the association with hemolytic anemia. Association between primary biliary cirrhosis and chronic viral hepatitis C is uncommon and associated with diagnostic and therapeutic challenges.
Service de gastro-entérologie, hôpital Charles-Nicolle, 1007 Tunis, Tunisie. leilamouelhi@yahoo.fr
L
L
Mouelhi
M
M
Chaieb
I
I
Sfar
R
R
Debbeche
S
S
Trabelsi
Y
Y
Gorgi
T
T
Najjar
D001323:Autoantibodies / Q000097:blood; D002779:Cholestasis / Q000209:etiology; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000150:complications* / Q000276:immunology; D008875:Middle Aged; D008930:Mitochondria, Liver / Q000276:immunology
D001323:Autoantibodies
Association hépatite chronique virale C et cirrhose biliaire primitive. A propos de deux observations.