An expeditious and environmentally friendly synthesis of 3-substituted isocoumarins using microwave irradiation.
A microwave-assisted, environmentally friendly, high-yielding, time-saving synthesis of medicinally important 3-substituted isocoumarins was carried out in a single step by direct condensation of homophthalic acid with aryol and acyl chlorides under solvent-free conditions without any solid support. The synthesised isocoumarins were structurally characterised by microanalysis, 1H NMR, EI, IR and UV.
Khan
Khalid Mohammed
KM
HEJ Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Pakistan. hassaan2@super.net.pk
Ahmed
Sumbul
S
Khan
Zulfiqar Ali
ZA
Rani
Mubeen
M
Perveen
Shahnaz
S
Voelter
Wolfgang
W
D049934:Isocoumarins / Q000138:chemical synthesis* / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D010795:Phthalic Acids / Q000737:chemistry
D049934:Isocoumarins; D010795:Phthalic Acids; C060218:homophthalic acid