Glandular stem cells are a promising source for much more than beta-cell replacement.
Glandular stem cells (GSCs) can be obtained from exocrine glands such as pancreas or salivary glands using well-established cell culturing methods. The resulting cell populations are characterized by a high proliferative capacity and an unusually high plasticity. Cells from pancreas have been demonstrated to differentiate into a multitude of cell types and even into oocyte-like cells. It has been found that the preparation method for GSCs can be applied to many vertebrates, including fishes and birds. Since the cells are excellently cryopreservable, this finding has been utilized to establish a new stem cell bank for preserving living cells of rare and wild animals. Apart from these advances, this mini-review also points out that GSCs from pancreas must not be confused with beta-cell progenitors but constitute a distinct cell type.
Fraunhofer-Einrichtung für Marine Biotechnologie, MGZ Paul-Ehrlich-Str. 1-3, 23562 Lübeck, Germany.
Daniel H
DH
Rapoport
Sandra
S
Danner
Charli
C
Kruse
D000328:Adult; D000818:Animals; D001709:Biotechnology / Q000379:methods / Q000639:trends; D001717:Birds; D015925:Cryopreservation / Q000379:methods; D053595:Embryonic Stem Cells / Q000166:cytology / Q000502:physiology; D005088:Exocrine Glands / Q000166:cytology / Q000502:physiology; D005399:Fishes; D006801:Humans; D050417:Insulin-Secreting Cells / Q000166:cytology* / Q000502:physiology*; D010179:Pancreas / Q000166:cytology* / Q000502:physiology; D012469:Salivary Glands / Q000166:cytology* / Q000502:physiology; D033581:Stem Cell Transplantation / Q000379:methods* / Q000639:trends; D013234:Stem Cells / Q000166:cytology* / Q000502:physiology; D014015:Tissue Banks / Q000458:organization & administration; D014714:Vertebrates