Antiproliferative compounds of Artabotrys madagascariensis from the Madagascar rainforest.
Bioassay-guided fractionation of an ethanol extract of Artabotrys madagascariensis led to the isolation of the new compound artabotrene (1), two butenolides (2 and 3), and the tetracyclic triterpene polycarpol (4). Structure elucidation was determined on the basis of one and two-dimensional NMR, and absolute configuration of compounds 2-4 was verified by analysis of CD and optical rotation spectra. Two of the isolates, melodorinol (2) and acetylmelodorinol (3), were found to display antiproliferative activity against five different tumour cell lines with IC50 values ranging from 2.4 to 12 microM.
Murphy
Brian T
BT
Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0212, USA.
Cao
Shugeng
S
Brodie
Peggy J
PJ
Miller
James S
JS
Ratovoson
Fidy
F
Birkinshaw
Chris
C
Rakotobe
Etienne
E
Rasamison
Vincent E
VE
Tendyke
Karen
K
Suh
Edward M
EM
Kingston
David G I
DG
D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000737:chemistry; D029061:Annonaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008270:Madagascar; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry
D010936:Plant Extracts; D014315:Triterpenes; C004511:butenolide; D015107:4-Butyrolactone