Calcium, dairy foods, vitamin D, and colorectal cancer risk: the Fukuoka Colorectal Cancer Study.
Epidemiologic evidence supporting a protective role of calcium and vitamin D in colorectal carcinogenesis has been accumulating in Western populations, but it is limited in Asian populations, whose intake of calcium is relatively low. We investigated the association of intakes of these nutrients with colorectal cancer risk in Japanese. Study subjects were participants of a large-scale case-control study in Fukuoka, Japan. Diet was assessed through interview regarding 148 dietary items by showing typical foods or dishes on the display of a personal computer. In a multivariate analysis adjusting for potential confounding variables, calcium intake was significantly, inversely associated with colorectal cancer risk (P for trend=0.01); the odds ratio for the highest versus lowest quintile of calcium intake was 0.64 (95% confidence interval, 0.45-0.93). Higher levels of dietary vitamin D were significantly associated with decreased risk of colorectal cancer among those who had fewer chances of sunlight exposure at work or in leisure (P for trend=0.02). A decreased risk of colorectal cancer associated with high calcium intake was observed among those who had higher levels of vitamin D intake or among those who had a greater chance of daily sunlight exposure, but not among those with medium or lower intake of vitamin D or among those with potentially decreased sunlight exposure. These results add to support for a joint action of calcium and vitamin D in the prevention of colorectal carcinogenesis.
Department of Epidemiology and International Health, Research Institute, International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan. mizoue@ri.imcj.go.jp
Tetsuya
T
Mizoue
Yasumi
Y
Kimura
Kengo
K
Toyomura
Jun
J
Nagano
Suminori
S
Kono
Ryuichi
R
Mibu
Masao
M
Tanaka
Yoshihiro
Y
Kakeji
Yoshihiko
Y
Maehara
Takeshi
T
Okamura
Koji
K
Ikejiri
Kitaroh
K
Futami
Yohichi
Y
Yasunami
Takafumi
T
Maekawa
Kenji
K
Takenaka
Hitoshi
H
Ichimiya
Nobutoshi
N
Imaizumi
D000368:Aged; D002118:Calcium / Q000008:administration & dosage*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology*; D003611:Dairy Products; D004032:Diet; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012306:Risk; D014807:Vitamin D / Q000008:administration & dosage*
D014807:Vitamin D; D002118:Calcium