Decline in pneumococcal meningitis in Spain after introduction of the heptavalent pneumococcal conjugate vaccine.
All patients < or =14 years old with a diagnosis of pneumococcal meningitis (n = 160) were included (2001, 2004-2006). Incidence per 100,000 child <5 years old varied from 6.14 in 2001 to 2.83 in 2006 (54% of reduction, P < 0.01). There was a significant correlation (R2 = 0.9506) with PCV7 distribution increase. No significant changes in the incidence by nonvaccine serotypes were found when comparing 2001 and 2006. The case fatality rate was 7.5%.
Hospital Niño Jesús, Madrid, Spain. jcasado.hnjs@salud.madrid.org
Juan
J
Casado-Flores
Carlos
C
Rodrigo
Javier
J
Arístegui
Jose María
JM
Martínón
Asunción
A
Fenoll
Cristina
C
Mendez
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008586:Meningitis, Pneumococcal / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control; D022401:Meningococcal Vaccines / Q000008:administration & dosage*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage*; D016133:Polymerase Chain Reaction; D011446:Prospective Studies; D012703:Serotyping; D013030:Spain / Q000453:epidemiology; D013296:Streptococcus pneumoniae / Q000145:classification
D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022401:Meningococcal Vaccines; D022242:Pneumococcal Vaccines