A review of adapalene in the treatment of acne vulgaris.
Topical retinoids help address the early lesions of acne vulgaris. Consensus guidelines advocate the use of topical retinoids as the primary treatment for most forms of acne vulgaris. However, all topical retinoid preparations may be irritating, and this may contribute to underutilization in clinical practices. Topical adapalene fosters topical retinoid treatment of acne with less irritation. Adapalene is a more stable molecule than tretinoin. Adapalene can be used without concern for photo-deactivation. Because of its chemical stability, adapalene can be used in combination with benzoyl peroxide products. The availability of a stable topical retinoid associated with little irritation may facilitate meeting acne treatment consensus guidelines.
Department of Dermatology, Center for Dermatology Research, Wake Forest University School of Medicine; Winston-Salem, North Carolina 27157-1071, USA.
Cynthia E
CE
Irby
Brad A
BA
Yentzer
Steven R
SR
Feldman
D000152:Acne Vulgaris / Q000188:drug therapy*; D000068816:Adapalene; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D009281:Naphthalenes / Q000494:pharmacology / Q000627:therapeutic use*; D012176:Retinoids / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009281:Naphthalenes; D012176:Retinoids; D000068816:Adapalene