Cross-correlogram between rat hippocampal and prefrontal neuronal activities.
We recorded spontaneous multiple unit activities (MUAs) of the hippocampus and prefrontal cortex in urethane-anesthetized rats and analyzed cross-correlograms between these MUAs to investigate the functional connectivity of neuronal activities. Results of these analyses reveal a significant correlation between MUAs in these regions, in which the firing initiated from either hippocampus (type H-P) or prefrontal cortex (type P-H) according to the significant peak of cross-correlograms. Furthermore, the MUA bursts were counted: a significant correlation was found between the peak height of cross-correlograms and MUA burst counts in type H-P, but not type P-H. These results suggest that the correlation between the hippocampus and prefrontal cortex MUAs that are related to the burst firing might reflect functional connectivity.
Fujiwara
Sei-Etsu
SE
Department of Physiology, School of Medicine, St Marianna University, Kawasaki, Japan. seitu@marianna-u.ac.jp
Akema
Tatsuo
T
Izaki
Yoshinori
Y
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001931:Brain Mapping / Q000379:methods; D004594:Electrophysiology / Q000379:methods; D006624:Hippocampus / Q000166:cytology / Q000502:physiology*; D008297:Male; D009415:Nerve Net / Q000166:cytology / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D017397:Prefrontal Cortex / Q000166:cytology / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar