The Year in Basic Science: nuclear receptors and coregulators.
This article highlights the most significant scientific achievements of June 2007 to June 2008 in nuclear receptors (NRs) and coregulators. These molecules are the subjects of nine studies in three key areas of endocrinology: molecular endocrinology, endocrine metabolism, and endocrine pathology. In each case, the relevant NR or coregulator was found to play an integral role in the study, whether in elucidating a formerly unknown pathway or in initiating or facilitating a disease process. As more NRs and coregulators are researched, more therapeutic approaches to human disease can potentially be developed.
O'Malley
Bert
B
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston Texas 77030-3498, USA. berto@bcm.tmc.edu
D000818:Animals; D035843:Biomedical Research / Q000639:trends; D004703:Endocrine System / Q000378:metabolism; D004700:Endocrine System Diseases / Q000235:genetics; D004704:Endocrinology / Q000639:trends; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D008958:Models, Molecular; D009369:Neoplasms / Q000209:etiology / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology*; D012097:Repressor Proteins / Q000502:physiology*; D015534:Trans-Activators / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology
D018160:Receptors, Cytoplasmic and Nuclear; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors