An unusual case of chronic coronary artery dissection: did cisplatin play a role?
Spontaneous coronary artery dissection is an unusual cause of acute myocardial ischemia. The natural history of spontaneous coronary artery dissection that persists on angiography after the acute event has not been well characterized. A case of a 36-year-old man who presented with monomorphic ventricular tachycardia 12 years following a myocardial infarction that occurred during his last course of bleomycin-etoposide-cisplatin therapy for testicular cancer is reported. On further investigation, coronary angiography revealed a long chronic dissection of the right coronary artery. The patient was successfully treated with medical management and insertion of an implantable cardioverter defibrillator. The case also highlights the increased cardiovascular morbidity in testicular cancer survivors and evokes the possibility of mechanisms of myocardial ischemia other than atherosclerotic disease in these young patients.
Division of Cardiology, University of Toronto, Toronto, Canada.
Nina
N
Ghosh
Chi-Ming
CM
Chow
Victoria
V
Korley
Robert
R
Chisholm
D000328:Adult; D000784:Aortic Dissection / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D015906:Angioplasty, Balloon, Coronary; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002908:Chronic Disease; D002945:Cisplatin / Q000009:adverse effects*; D003323:Coronary Aneurysm / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D017023:Coronary Angiography; D003937:Diagnosis, Differential; D004562:Electrocardiography; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D013736:Testicular Neoplasms / Q000188:drug therapy
D000970:Antineoplastic Agents; D002945:Cisplatin