Prenatal diagnosis of schizencephaly with septo-optic dysplasia by ultrasound and magnetic resonance imaging.
A 28-year-old woman, gravida 1, para 0, was referred to our fetal diagnosis unit at 28(+2) gestational weeks because no fetal movements were detected. On 2-D ultrasonography, the cephalic axial view showed multiple hypoechoic spaces in the fetal brain, both cerebral cortex and occipital lobe showed bilateral defects, and the septum pellucidum was absent. Multiple irregularly shaped cystic lesions connected with subarachnoid spaces were observed by three-dimensional ultrasonography in surface rendering mode. Septo-optic dysplasia with dysgenesis of corpus callosum was confirmed by prenatal magnetic resonance imaging (MRI). The fetus was complicated with cleft schizencephaly involving bilateral frontal, parietal and occipital lobes, which can often lead to learning disability, epilepsy and cerebral palsy after birth. The flaccid mobility of all four extremities of the fetus, demonstrated prenatally by real-time ultrasound and functional MRI, forecast the risk of postnatal spastic quadriplegia.
Department of Obstetrics and Gynecology, Buddhist Tzu Chi General Hospital, Taipei, Taiwan. jhhung@tzuchi.com.tw
Jeng-Hsiu
JH
Hung
Shu-Huei
SH
Shen
Wan-You
WY
Guo
Chih-Yao
CY
Chen
Kuan-Chong
KC
Chao
Ming-Jie
MJ
Yang
Chia-Yi Selena
CY
Hung
D000328:Adult; D002540:Cerebral Cortex / Q000002:abnormalities; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D054220:Malformations of Cortical Development / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D011247:Pregnancy; D025962:Septo-Optic Dysplasia / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D017585:Ultrasonography, Doppler, Transcranial; D016216:Ultrasonography, Prenatal