Sulfasalazine-induced DRESS syndrome (Drug Rash with Eosinophilia and Systemic Symptoms).
BACKGROUND
DRESS syndrome (Drug Rash with Eosinophilia and Systemic Symptoms) is a type of drug reaction commonly mistaken for a viral infection. It must be recognized promptly due to its high morbidity and 10% mortality rate. Few cases of DRESS syndrome induced by sulfasalazine have been reported in the literature.


METHODS
The case of a 47-year-old white Brazilian woman who developed DRESS syndrome eight weeks after starting a course of sulfasalazine for treatment of seronegative arthritis is reported. She presented a skin rash, fever, hepatitis, lymphadenopathy, eosinophilia and atypical lymphocytes. The causative drug was discontinued immediately, but she only improved after treatment with prednisone.
Department of Internal Medicine, Faculdade de Ciências Médicas, Santa Casa de São Paulo, São Paulo, Brazil. renata_aquino@uol.com.br
Renata Telles Rudge de
RT
Aquino
Carmen Silvia Vieitas
CS
Vergueiro
Maria Elisa Ruffolo
ME
Magliari
Thais Helena Proença
TH
de Freitas
D018501:Antirheumatic Agents / Q000009:adverse effects*; D001168:Arthritis / Q000188:drug therapy; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology*; D004802:Eosinophilia / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008875:Middle Aged; D012460:Sulfasalazine / Q000009:adverse effects*; D013577:Syndrome
D018501:Antirheumatic Agents; D012460:Sulfasalazine