Mass spectrometry-based proteomics: principles, perspectives, and challenges.
Mass spectrometry-based proteomics is a modern and rapidly developing methodology for qualitative and quantitative characterization of proteins and their posttranslational modification, subcellular localization, and interaction partners. It enables characterization of entire proteomes with unprecedented sensitivity and precision, providing platforms for identification of biomarkers and drug targets.
Wiśniewski
Jacek R
JR
Department of Proteomics and Signal Transduction, The Max-Planck-Institute for Biochemistry, Martinsried, Germany. jwisniew@biochem.mpg.de
D015415:Biomarkers / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism; D013058:Mass Spectrometry / Q000379:methods* / Q000639:trends; D011499:Protein Processing, Post-Translational; D040901:Proteomics / Q000379:methods* / Q000639:trends
D015415:Biomarkers