Type I (sporadic) porphyria cutanea tarda in a hemodialysis patient: a case report.
A hemodialysis patient with hepatitis C virus infection developed painful blisters on her hands that burst spontaneously. She was found to have serum porphyrin levels >2000 nmol/L. A punch biopsy revealed subepidermal blistering with festooning of dermal papillae associated with a mixed inflammatory infiltrate. Based on the clinical, biochemical, and histologic findings, a diagnosis of porphyria cutanea tarda was made. Treatment was started with twice-weekly phlebotomy and oral hydroxychloroquine and significant clinical improvement resulted.
Tarwater
Kurt
K
Division of Nephrology, University of Missouri Health Sciences Center, Columbia, Missouri, USA.
Misra
Shamita
S
Misra
Madhukar
M
D004791:Enzyme Inhibitors / Q000008:administration & dosage; D005260:Female; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D006886:Hydroxychloroquine / Q000008:administration & dosage; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008875:Middle Aged; D018962:Phlebotomy; D017119:Porphyria Cutanea Tarda / Q000150:complications* / Q000188:drug therapy; D006435:Renal Dialysis
D004791:Enzyme Inhibitors; D006886:Hydroxychloroquine