Imines that react with phenols in water over a wide pH range.
Cyclic imine derivatives that react with phenols, including tyrosine residues of peptides, have been developed. Reactions of the imines with phenols proceeded in water over a wide pH range (pH 2-10) at room temperature to 37 degrees C and afforded Mannich products without the need of additional catalysts.
Minakawa
Maki
M
Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Guo
Hai-Ming
HM
Tanaka
Fujie
F
D006863:Hydrogen-Ion Concentration; D007097:Imines / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry*; D012996:Solutions; D014867:Water
D007097:Imines; D010636:Phenols; D012996:Solutions; D014867:Water