Effect of Qiangxin Fumai Granule () on electrophysiological functions of the sinoatrial node during ischemia-reperfusion of the right coronary artery in rabbits.
OBJECTIVE
To study the effect of the Chinese medicine Qiangxin Fumai Granule (, QFG) on electrophysiological functions of the sinoatrial node during ischemia-reperfusion (IR) of the right coronary artery in rabbits.


METHODS
The right coronary artery IR model in rabbits was adopted. The modeled rabbits were randomly divided into 4 groups: the model group, the atropine group, the high-dose QFG group, and the low-dose QFG group, with 8 animals in each group. In addition, twelve rabbits were selected for the sham-operative group. The drugs were administered once via duodenal perfusion after modeling had been stabilized for 10 min. The changes in AA interval, the sinoatrial conduction time (SACT), the sinus node recovery time (SNRT), the corrected sinus node recovery time (CSNRT) and the index of sinus node recovery time (ISNRT) at different time points during ischemia and reperfusion were measured.


RESULTS
The AA interval was prolonged for more than 40 ms in the model group during ischemia. Compared with the model group, the four electrophysiological parameters abovementioned in the high-dose QFG group and the low-dose QFG group were decreased to different extents at each time point (P<0.01 or P<0.05), and no statistically significant differences were found between the QFG groups and the atropine group (P>0.05).


CONCLUSIONS
QFG is beneficial for accelerating the recovery of sinus node autorhythmicity and conduction function, so as to protect electrophysiological functions of the sinoatrial node. Accelerating the recovery of autorhythmicity and conduction function in the sinus node is considered its electrophysiological mechanism in the treatment of sinoatrial node injury induced by ischemia.
Liu
Ru-xiu
RX
Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China. liuruxiu1@yahoo.com.cn
Tan
Shuang
S
Liu
Zhi-ming
ZM
Wang
Jie
J
Wang
Yan-yun
YY
D000818:Animals; D003331:Coronary Vessels / Q000187:drug effects* / Q000503:physiopathology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D055724:Electrophysiological Phenomena / Q000187:drug effects*; D006329:Heart Conduction System / Q000187:drug effects; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy / Q000503:physiopathology*; D008517:Phytotherapy; D011817:Rabbits; D012849:Sinoatrial Node / Q000187:drug effects* / Q000503:physiopathology*; D013997:Time Factors
D004365:Drugs, Chinese Herbal; C532896:qiangxin fumai