Preventive effect of Streptococcus thermophilus YIT 2001 on dextran sulfate sodium-induced colitis in mice.
We investigated the preventive effect of Streptococcus thermophilus YIT 2001, a lactic acid bacterum having high antioxidative activity, on acute colitis induced by 2.5% dextran sulfate sodium in mice, and compared the effect with that of S. thermophilus YIT 2084 which has lower antioxidative activity. Feeding S. thermophilus YIT 2001 decreased the disease activity index and level of lipid peroxide (the thiobarbituric acid reactive substance content) in the colonic mucosa. The hematocrit and hemoglobin concentrations in the blood of S. thermophilus YIT 2001-fed mice were higher than those of the control mice. S. thermophilus YIT 2084 had no significant effect on these parameters. The results suggest that the antioxidative activity of S. thermophilus YIT 2001 was involved in the improving effect on colitis.
Ito
Masahiko
M
Yakult Central Institute for Microbiological Research, Tokyo, Japan. masahiko-ito@yakult.co.jp
Ohishi
Kenji
K
Yoshida
Yasuto
Y
Okumura
Takekazu
T
Sato
Tadashi
T
Yokoi
Wakae
W
Sawada
Haruji
H
D000821:Animal Feed; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D003092:Colitis / Q000139:chemically induced / Q000378:metabolism / Q000382:microbiology* / Q000517:prevention & control*; D016264:Dextran Sulfate / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D048249:Streptococcus thermophilus / Q000502:physiology*
D000975:Antioxidants; D016264:Dextran Sulfate