[Prevalence of neutralizing antibodies to dengue virus serotypes in university students from Tabasco, Mexico].
OBJECTIVE
Determine the seroprevalence of neutralizing antibodies to dengue virus in students from the state university of Tabasco, Mexico.


METHODS
A transversal study was conducted of serum collected from students between September and November, 2005. The sera were screened for anti-dengue IgG and those that had evidence of dengue antibodies were analyzed by a plaque reduction neutralization test.


RESULTS
Prevalence of anti-dengue IgG was 9.1%. The frequency of neutralizing antibodies was 100% for DENV-2, 68% for DENV-4, 20% for DENV-1, and 4 % for DENV-3.


CONCLUSIONS
We found that in this population, DENV-2 circulates more than DENV-3 despite the fact that DENV-3 is more frequently isolated. Unexpectedly, neutralizing antibodies against DENV-4 were frequently found even though this serotype is almost extinct; thus, it is probable that cross-immunity could suppress DEN-4 transmission, as has been suggested.
Sánchez-Burgos
Gilma Guadalupe
GG
Unidad de Investigación Médica, Yucatán.
López-Alvarado
Miguel Angel
MA
Castañeda-Desales
Deyanira
D
Ruiz-Gómez
Juan
J
Ramos-Castañeda
José
J
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood* / Q000276:immunology; D003429:Cross Reactions; D003430:Cross-Sectional Studies; D003715:Dengue / Q000097:blood / Q000453:epidemiology* / Q000635:transmission / Q000821:virology; D003716:Dengue Virus / Q000145:classification / Q000254:growth & development / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood* / Q000276:immunology; D008297:Male; D008800:Mexico / Q000453:epidemiology; D009500:Neutralization Tests; D016036:Seroepidemiologic Studies; D012703:Serotyping; D013334:Students; D014495:Universities; D010948:Viral Plaque Assay; D055815:Young Adult
D000914:Antibodies, Viral; D007074:Immunoglobulin G
Prevalencia de anticuerpos neutralizantes contra los serotipos del virus dengue en universitarios de Tabasco, México.