Electrophysiological correlates of the brain's intrinsic large-scale functional architecture.
Spontaneous fluctuations in the blood-oxygen-level-dependent (BOLD) signals demonstrate consistent temporal correlations within large-scale brain networks associated with different functions. The neurophysiological correlates of this phenomenon remain elusive. Here, we show in humans that the slow cortical potentials recorded by electrocorticography demonstrate a correlation structure similar to that of spontaneous BOLD fluctuations across wakefulness, slow-wave sleep, and rapid-eye-movement sleep. Gamma frequency power also showed a similar correlation structure but only during wakefulness and rapid-eye-movement sleep. Our results provide an important bridge between the large-scale brain networks readily revealed by spontaneous BOLD signals and their underlying neurophysiology.
Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA. bhea@wustl.edu
Biyu J
BJ
He
Abraham Z
AZ
Snyder
John M
JM
Zempel
Matthew D
MD
Smyth
Marcus E
ME
Raichle
D000200:Action Potentials; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D004594:Electrophysiology; D004827:Epilepsy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008564:Membrane Potentials; D012890:Sleep; D012895:Sleep, REM; D014851:Wakefulness / Q000502:physiology