Successful treatment of relapsed lymphomatoid granulomatosis with bexarotene.
Lymphomatoid granulomatosis is a rare lymphoproliferative disorder involving the lungs, skin and other organs. Advanced-stage disease does not tend to respond well to cytotoxic chemotherapy and is associated with a poor prognosis. We present a case of successful treatment of relapsed lymphomatoid granulomatosis with bexarotene, a novel retinoid agent.
Abramson Cancer Center, Hospital of the University of Pennsylvania, University of Pennsylvania, Philadelphia, PA 19104, USA.
Sigrid E
SE
Berg
Lisa H
LH
Downs
Drew A
DA
Torigian
Elise A
EA
Chong
Donald E
DE
Tsai
Mariusz A
MA
Wasik
Stephen J
SJ
Schuster
D000328:Adult; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology; D000077610:Bexarotene; D003520:Cyclophosphamide / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D006801:Humans; D008230:Lymphomatoid Granulomatosis / Q000188:drug therapy* / Q000473:pathology*; D008297:Male; D011239:Prednisolone / Q000494:pharmacology; D011379:Prognosis; D012008:Recurrence; D012074:Remission Induction; D012176:Retinoids / Q000378:metabolism; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*; D016896:Treatment Outcome; D014750:Vincristine / Q000494:pharmacology
D000970:Antineoplastic Agents; D012176:Retinoids; D013764:Tetrahydronaphthalenes; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone; D000077610:Bexarotene