Differential effects of two isoenergetic meals rich in saturated or monounsaturated fat on endothelial function in subjects with type 2 diabetes.
OBJECTIVE
To examine the acute effects of consumption of monounsaturated (MUFAs) and saturated fatty acids (SAFAs) on endothelial function in subjects with type 2 diabetes.


METHODS
A total of 33 participants were examined after consumption of two different isocaloric meals: one rich in MUFA and one rich in SAFA, in the form of extra-virgin olive oil and butter, respectively. Endothelial function was assessed by determination of flow-mediated dilatation (FMD).


RESULTS
FMD did not change significantly after the MUFA-rich meal but declined after the SAFA-rich meal. The FMD during the experiment, expressed as incremental area under the curve, increased after the MUFA-rich meal by 5.2 +/- 2.5% and decreased after the SAFA-rich meal by 16.7 +/- 6.0% (Delta = -11.5 +/- 6.4%; P = 0.008).


CONCLUSIONS
Consumption of an SAFA-rich meal is harmful for the endothelium, while a MUFA-rich meal does not impair endothelial function in subjects with type 2 diabetes.
First Department of Propaedeutic Medicine, Laiko General Hospital, Athens University Medical School, Athens, Greece. ntentol@med.uoa.gr
Nicholas
N
Tentolouris
Christina
C
Arapostathi
Despoina
D
Perrea
Despoina
D
Kyriaki
Constantinos
C
Revenas
Nicholas
N
Katsilambros
D000368:Aged; D002079:Butter; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000187:drug effects*; D005227:Fatty Acids / Q000008:administration & dosage / Q000494:pharmacology*; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000069463:Olive Oil; D010938:Plant Oils; D014664:Vasodilation / Q000187:drug effects*
D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D000069463:Olive Oil; D010938:Plant Oils; D002079:Butter