[Liver function abnormalities in undernourished and Schistosoma mansoni-infected mice].
There are few studies on liver function abnormalities in mice with schistosomiasis associated with malnutrition. In this study, animals were divided into four groups, according to their diet (normal or low protein) and whether they were infected with Schistosoma mansoni or not. All the groups grew slower than the control did (p < 0.0001). Mortality among the animals occurred because of the infection. High levels of aminotransferases in well-fed animals with infection suggested that there was an intensive inflammatory process (p < 0.0001). All the groups presented high levels of alkaline phosphatase. There were increases in aspartate transferase and alkaline phosphatase in infected well-fed animals. The diets modified the albumin levels (p > 0.001) and the serum proteins. Compared with the controls, the groups showed low levels of glucose (p < 0.001). This study found that both infection and malnutrition interfered with the biochemical indicator levels, but the most important liver function abnormalities occurred during the intense inflammation caused by schistosomiasis.
Setor de Parasitologia, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Maceió, AL. janelu4@uol.com.br
Janira Lúcia Assumpção
JL
Couto
Regina Coeli da Silva
RC
Vieira
Janine Maciel
JM
Barbosa
Sônia Salgueiro
SS
Machado
Haroldo da Silva
Hda S
Ferreira
D000418:Albumins / Q000032:analysis; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood; D005947:Glucose / Q000032:analysis; D008099:Liver / Q000469:parasitology / Q000503:physiopathology*; D008111:Liver Function Tests; D008297:Male; D051379:Mice; D011502:Protein-Energy Malnutrition / Q000097:blood / Q000503:physiopathology*; D012550:Schistosoma mansoni; D012555:Schistosomiasis mansoni / Q000097:blood / Q000503:physiopathology*; D000637:Transaminases / Q000097:blood
D000418:Albumins; D015415:Biomarkers; D000637:Transaminases; D001219:Aspartate Aminotransferases; D000469:Alkaline Phosphatase; D005947:Glucose
Alterações da função hepática de camundongos desnutridos e infectados pelo Schistosoma mansoni.