Repeated high doses of clopidogrel in 2 cases of pharmacological resistance.
In the case of stent thrombosis and resistance to clopidogrel, choices of an alternative drug remain limited. In 2 cases of subacute stent thrombosis associated with clopidogrel resistance, an adequate response was obtained in these patients after repeated loading doses of clopidogrel.
Cayla
Guillaume
G
Department of Cardiology, Hôpital Arnaud de Villeneuve, Centre Hospitalier Universitaire, Montpellier, France. guillaumecayla@free.fr
Macia
Jean Christophe
JC
Roubille
François
F
Rabesendratana
Herisoa
H
Piot
Christophe
C
Schved
Jean François
JF
Leclercq
Florence
F
D054058:Acute Coronary Syndrome / Q000628:therapy*; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000097:blood; D000077144:Clopidogrel; D004334:Drug Administration Schedule; D004351:Drug Resistance; D006801:Humans; D008297:Male; D008840:Microfilament Proteins / Q000097:blood; D008875:Middle Aged; D010750:Phosphoproteins / Q000097:blood; D010766:Phosphorylation; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D010979:Platelet Function Tests; D013927:Thrombosis / Q000209:etiology / Q000517:prevention & control*; D013988:Ticlopidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D017211:Treatment Failure; D000098662:Vasodilator-Stimulated Phosphoprotein
D015815:Cell Adhesion Molecules; D008840:Microfilament Proteins; D010750:Phosphoproteins; D010975:Platelet Aggregation Inhibitors; D000098662:Vasodilator-Stimulated Phosphoprotein; D000077144:Clopidogrel; D013988:Ticlopidine