[Fish oil supplementation in rheumatoid arthritis].
The beneficial properties of fish oil are well known and are related to its fatty acid composition rich in omega-3 polyunsaturated fatty acids. In the last years a variety of epidemiological and clinical studies have demonstrated the efficacy of fish oil supplementation in the rheumatic diseases, in particular in rheumatoid arthritis. The anti-inflammatory effects of fish oil are linked to the production of alternative eicosanoids, to the reduction of proinflammatory cytokines, to the inhibition of the activation of T lymphocytes and of catabolic enzymes. Fish oil supplementation could represent a valuable support to the traditional pharmacological treatment of rheumatoid arthritis.
Servizio di Dietetica e Nutrizione Clinica, Dipartimento di Medicina Clinica e Sperimentale, Università di Padova, Padova.
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D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000191:economics / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D016572:Cyclosporine / Q000493:pharmacokinetics; D019587:Dietary Supplements; D016527:Drug Costs; D004347:Drug Interactions; D015118:Eicosapentaenoic Acid / Q000494:pharmacology / Q000627:therapeutic use; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology / Q000627:therapeutic use; D005395:Fish Oils / Q000191:economics / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008727:Methotrexate / Q000493:pharmacokinetics; D012460:Sulfasalazine / Q000493:pharmacokinetics
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005231:Fatty Acids, Unsaturated; D005395:Fish Oils; D012460:Sulfasalazine; D016572:Cyclosporine; D015118:Eicosapentaenoic Acid; C026219:docosapentaenoic acid; D008727:Methotrexate
La supplementazione dietetica con olio di pesce nell'artrite reumatoide.