Chemotherapy for laryngeal cancer--an apoptotic approach.
Laryngeal cancer is a common head and neck cancer. Despite advances in treatment, improvement in survival and quality of life of patients still remains a challenge. Chemotherapy has become more and more important since this treatment is able to preserve laryngeal function. There is increasing evidence showing that many chemotherapeutic agents kill laryngeal tumor cells via apoptotic mechanisms. The balance between anti-apoptotic molecules and pro-apoptotic ones plays a critical role in determining the sensitivity of the tumor cells to chemotherapy. The commonly used chemotherapeutic agents for laryngeal cancer include cisplatin, 5-fluorouracil and paclitaxel. These three agents may target common apoptotic molecules, but more importantly they have their own particular targets. Systemically analysis of these targets will not only help to optimize the treatment but also provide a rationale for the best combination of two or more agents for the chemotherapy of laryngeal cancer.
Department of Surgery, Prince of Wales Hospital, Shatin, N.T., Hong Kong.
Han Ching
HC
Liu
George G
GG
Chen
Alexander C
AC
Vlantis
Michael C F
MC
Tong
C Andrew
CA
van Hasselt
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology
D000970:Antineoplastic Agents