[Study on absorption kinetics of astragaloside IV in rats intestines].
OBJECTIVE
To investigate the mechanisms of intestine absorption of astragaloside IV in rat.


METHODS
The K(a) and P(app) of astragaloside IV was investigated using single-pass intestinal perfusion technique in rats. HPLC was used to determine the concentration of astragaloside IV. The effect of absorption site, drug concentration and the inhibitors of P-glycoproteon on the absorption had been studied.


RESULTS
By the testing of the statistics, the K(a) and the P(app) values of the duodenum, jejunum, ileum, colonic had significant differences (P < 0.05). The concentration from 20-80 mg x L(-1) had no distinctive effect on the K(a) and P(app) of small intestine. The inhibitors of P-glycoproteon had no distinctive effect on the absorption of small intestine.


CONCLUSIONS
Astragaloside IV is absorbed by typical passive diffusion mechanism.
Hebei Ping'an Healthy Group Co. Ltd., Shijiazhuang 050021, China. huang71526@163.com
Huai-Peng
HP
Huang
Cai-Xia
CX
Liu
Yan-Ling
YL
Li
Guo-Ling
GL
Gao
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000037:antagonists & inhibitors; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D007408:Intestinal Absorption / Q000187:drug effects; D007413:Intestinal Mucosa / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D010477:Perfusion; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000378:metabolism / Q000493:pharmacokinetics*; D014315:Triterpenes / Q000378:metabolism / Q000493:pharmacokinetics*; D014700:Verapamil / Q000494:pharmacology
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D012503:Saponins; D014315:Triterpenes; C052064:astragaloside A; D014700:Verapamil