Effects of growth hormone reduction in a patient with polycystic ovary syndrome complicated with acromegaly.
We report a rare case of polycystic ovary syndrome (PCOS) complicated with acromegaly due to a growth hormone (GH)-producing pituitary adenoma. Complete removal of the pituitary adenoma successfully reduced circulating levels of GH and insulin-like growth factor (IGF)-1, which, in turn, resulted in the amelioration of gonadal dysfunction, hyperandrogenism, lutenizing hormone hypersecretion, and severe insulin resistance. This clinical complication suggests that activation of systemic GH-IGF-1 axis is potentially involved in the development of PCOS.
Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
Junko
J
Goto
Fumio
F
Otsuka
Kenichi
K
Inagaki
Naoko
N
Tsukamoto
Jiro
J
Suzuki
Tomoko
T
Miyoshi
Toshio
T
Ogura
Yasuhiko
Y
Kamada
Hirofumi
H
Makino
D000172:Acromegaly / Q000097:blood / Q000150:complications* / Q000601:surgery; D000236:Adenoma / Q000097:blood / Q000378:metabolism / Q000601:surgery*; D000328:Adult; D015536:Down-Regulation / Q000502:physiology; D005260:Female; D013006:Growth Hormone / Q000097:blood* / Q000378:metabolism; D049912:Growth Hormone-Secreting Pituitary Adenoma / Q000097:blood / Q000378:metabolism / Q000601:surgery*; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications* / Q000209:etiology / Q000601:surgery; D016896:Treatment Outcome
D013006:Growth Hormone