A simple one-pot preparation of diazoacetoacetate derivatives from aldehydes.
Diazoacetoacetate derivatives can be simply and efficiently prepared from aldehydes in a one-pot process involving initial DBU-promoted "aldol" condensation with ethyl diazoacetate followed by in situ oxidation with IBX. Aryl, alkyl, and unsaturated aldehydes are all viable substrates.
Erhunmwunse
Marvis O
MO
Department of Chemistry, University of Durham, Science Laboratories, South Road, Durham DH1 3LE, UK.
Steel
Patrick G
PG