Evaluation of wound healing activity of Lantana camara L. - a preclinical study.
Lantana camara is used in herbal medicine for the treatment of skin itches, as an antiseptic for wounds, and externally for leprosy and scabies. The objective of our study was to investigate excision wound healing activity of the leaf extract of L. camara in rats. The animals were divided into two groups of 12 each in both the models. The test group animals were treated with the aqueous extract of L. camara (100 mg/kg/day) topically and the control group animals were left untreated. Wound healing efficacy was measured by determining the morphological and biochemical parameters. Wound healing time, wound contraction and synthesis of collagen were monitored periodically. Antimicrobial activities of the extract against the microorganisms were also assessed. Treatment of the wounds with extract enhanced significantly the rate of wound contraction (98%), synthesis of collagen and decreased mean wound healing time. These studies demonstrate that L. camara is effective in healing excision wounds in the experimental animal and could be evaluated as a therapeutic agent in tissue repair processes associated with skin injuries.
Department of Preclinical Sciences, Biochemistry Unit, Faculty of Medical Sciences, The University of the West Indies, St Augustine, Trinidad. shiv25@gmail.com
B Shivananda
BS
Nayak
S Sivachandra
SS
Raju
Mathew
M
Eversley
Adash
A
Ramsubhag
D000818:Animals; D003094:Collagen / Q000096:biosynthesis; D032410:Lantana / Q000737:chemistry*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000187:drug effects / Q000293:injuries*; D014945:Wound Healing / Q000187:drug effects*
D010936:Plant Extracts; D003094:Collagen