Serum adhesion molecule levels in acute coronary syndrome among Indonesian patients.
OBJECTIVE
to observe whether the VCAM and ICAM level in ACS patients were higher than those in coronary heart disease (CHD) patients. In addition, we would like to observe the cut off point of VCAM and ICAM level in ACS patients.


METHODS
in observational study, as many as 146 subjects were analyzed, consisting of 84 ACS patients, and 62 coronary heart disease (CHD) patients. This study were conducted at Dr. Cipto Mangunkusumo General Hospital (RSUPN-CM), Persahabatan Hospital, MMC Hospital and Medistra Hospital, Jakarta. The study was carried out from May 2005 to May 2006.


RESULTS
the VCAM level was higher in the group of ACS patients (mean 981.06 ng/mL, SD 319.28, CI 95%: 911.77-1050.35) than in that in the group of CHD (mean 915.23 ng/mL, SD 283.05, CI 95%: 843.35-987.11), but the difference is not significant. At cut-off point of VCAM level >or= 920.8 ng/mL, the highest sensitivity (57.14%) and highest specificity (67.74%) were found with ROC of 0.58. The ICAM level was higher in the group of ACS patients (mean 268.08 ng/mL, SD 72.75, CI 95%: 252.29/283.87) than that in the group of CHD (mean 245.18 ng/mL, SD 87.37, CI 95%: 222.99-267.37), but the difference is not significant. At cut-off point of ICAM level 248.6 ng/mL, the highest sensitivity (54.76%) and highest specificity (66.13%) were found with ROC of 0.62.


CONCLUSIONS
it could be concluded that VCAM and ICAM level in ACS were higher than in CHD, but the difference is not significant. The VCAM and ICAM level are not the best parameter to differentiate between acute (ACS) and stable (CHD) condition.
Department of Internal Medicine, Faculty of Medicine University of Indonesia-Dr. Cipto Mangunkusumo Hospital, Jalan Diponegoro no. 71, Jakarta. idrus@hotmail.com
Idrus
I
Alwi
D054058:Acute Coronary Syndrome / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood; D042783:Endothelial Cells; D006801:Humans; D015994:Incidence; D007214:Indonesia / Q000453:epidemiology; D007249:Inflammation / Q000097:blood; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D007962:Leukocytes; D012680:Sensitivity and Specificity; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
D015415:Biomarkers; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1