Contribution of the blood glucose level in perinatal asphyxia.
This is a comparative study between 60 asphyxiated newborns (cases) and 60 normal neonates (controls) in respect of their plasma glucose and uric acid levels and also their clinical and neurological status. The mean plasma glucose level was significantly lower (35.1 +/- 11.4 mg/dl vs. 56.9 +/- 5.5 mg/dl; P < 0.001) and the mean serum uric acid level was higher (8.0 +/- 1.2 mg/dl vs. 4.5 +/- 0.83 mg/dl; P < 0.001) in the asphyxiated group when compared to the controls. Within the perinatal asphyxia group, the plasma glucose level and Apgar scores showed a significant positive linear correlation (r = 0.740, P < 0.001), whereas a significant negative linear correlation was observed between the glucose level and different stages of hypoxic ischemic encephalopathy (HIE) (r = -0.875, P < 0.001). Although a strong positive linear correlation was found between uric acid and HIE stages (r = 0.734, P < or = 0.001), the linear correlation between uric acid and Apgar scores (r = -0.885, P < 0.001) and uric acid and the plasma glucose level (r = -0.725, P < 0.001) were found to be significantly negative among the cases.


CONCLUSIONS
The severity of encephalopathy and cellular damage varies with the severity of hypoglycemia.
Department of Biochemistry, Burdwan Medical College and Hospital, Burdwan, West Bengal, India. dr.pallab_basu@rediffmail.com
Pallab
P
Basu
Sabbasachi
S
Som
Nabendu
N
Choudhuri
Harendranath
H
Das
D001034:Apgar Score; D001238:Asphyxia Neonatorum / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006761:Hospitals; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000097:blood / Q000209:etiology / Q000503:physiopathology*; D007231:Infant, Newborn; D016014:Linear Models; D008297:Male; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D014527:Uric Acid / Q000097:blood*
D014527:Uric Acid; D005947:Glucose