Centrioles: some self-assembly required.
Centrioles play an important role in organizing microtubules and are precisely duplicated once per cell cycle. New (daughter) centrioles typically arise in association with existing (mother) centrioles (canonical assembly), suggesting that mother centrioles direct the formation of daughter centrioles. However, under certain circumstances, centrioles can also selfassemble free of an existing centriole (de novo assembly). Recent work indicates that the canonical and de novo pathways utilize a common mechanism and that a mother centriole spatially constrains the self-assembly process to occur within its immediate vicinity. Other recently identified mechanisms further regulate canonical assembly so that during each cell cycle, one and only one daughter centriole is assembled per mother centriole.
Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Mi Hye
MH
Song
Nicholas B
NB
Miliaras
Nina
N
Peel
Kevin F
KF
O'Connell
D000818:Animals; D002453:Cell Cycle; D002455:Cell Division; D002502:Centrioles / Q000502:physiology*; D006801:Humans; D008870:Microtubules / Q000378:metabolism; D008954:Models, Biological