Effect of prenatal lead exposure on superoxide dismutase activity in the brain and liver of rat fetuses.
Prenatal lead exposure had a damaging effect on Cu/Zn superoxide dismutase activity in the brain and liver of rat fetuses (20 days of gestation). The decrease in Cu/Zn superoxide dismutase activity in the brain and liver of treated fetuses reflects activation of free radical processes and impairment of the antioxidant defense system during prenatal lead exposure.
Moscow Institute of Psychiatry, Federal Agency for Health Care and Social Development. uzbekovmg@mtu-net.ru
M G
MG
Uzbekov
N I
NI
Bubnova
G V
GV
Kulikova
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D005260:Female; D005333:Fetus / Q000187:drug effects; D007854:Lead / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D009566:Nitrates / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000201:enzymology*; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism*
D009566:Nitrates; D007854:Lead; C017461:lead nitrate; D013482:Superoxide Dismutase