Susceptibility variants for male-pattern baldness on chromosome 20p11.
We carried out a genome-wide association study in 296 individuals with male-pattern baldness (androgenetic alopecia) and 347 controls. We then investigated the 30 best SNPs in an independent replication sample and found highly significant association for five SNPs on chromosome 20p11 (rs2180439 combined P = 2.7 x 10(-15)). No interaction was detected with the X-chromosomal androgen receptor locus, suggesting that the 20p11 locus has a role in a yet-to-be-identified androgen-independent pathway.
Hillmer
Axel M
AM
Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany. axel.hillmer@uni-bonn.de
Brockschmidt
Felix F
FF
Hanneken
Sandra
S
Eigelshoven
Sibylle
S
Steffens
Michael
M
Flaquer
Antonia
A
Herms
Stefan
S
Becker
Tim
T
Kortüm
Anne-Katrin
AK
Nyholt
Dale R
DR
Zhao
Zhen Zhen
ZZ
Montgomery
Grant W
GW
Martin
Nicholas G
NG
Mühleisen
Thomas W
TW
Alblas
Margrieta A
MA
Moebus
Susanne
S
Jöckel
Karl-Heinz
KH
Bröcker-Preuss
Martina
M
Erbel
Raimund
R
Reinartz
Roman
R
Betz
Regina C
RC
Cichon
Sven
S
Propping
Peter
P
Baur
Max P
MP
Wienker
Thomas F
TF
Kruse
Roland
R
Nöthen
Markus M
MM
D000328:Adult; D000505:Alopecia / Q000235:genetics*; D002890:Chromosomes, Human, Pair 20 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D015894:Genome, Human / Q000235:genetics; D005858:Germany; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics