Adaptation of the cardiovascular system to postinfarction cardiosclerosis in rats with congenital adrenoreactivity of the myocardium.
Three months after myocardial infarction the severity of heart failure and size of postinfarction scars in August rats with inherently reduced adrenoreactivity of the myocardium were similar to those in Wistar rats. The mortality rate in August rats was 2.5-fold lower than in Wistar rats. During the postinfarction period, myocardial adrenoreactivity in August rats remained lower, while the efficiency of cardiac function was 62% higher than in Wistar rats. The incidence of epinephrine-induced arrhythmias in August rats was much lower than in Wistar rats.
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
M A
MA
Usacheva
E V
EV
Popkova
E A
EA
Smirnova
V A
VA
Saltykova
L M
LM
Belkina
D000818:Animals; D002395:Catecholamines / Q000378:metabolism; D004837:Epinephrine; D009203:Myocardial Infarction / Q000150:complications / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D012598:Sclerosis / Q000209:etiology; D013045:Species Specificity
D002395:Catecholamines; D011943:Receptors, Adrenergic, beta; D004837:Epinephrine