Improvement of MRI-functional measurement with automatic movement correction in native and transplanted kidneys.
OBJECTIVE
To improve 2D software for motion correction of renal dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and to evaluate its effect using the Patlak-Rutland model.


METHODS
A subpixel-accurate method to correct for kidney motion during DCE-MRI was evaluated on native and transplanted kidneys using data from two different institutions with different magnets and protocols. The Patlak-Rutland model was used to calculate glomerular filtration rate (GFR) on a voxel-by-voxel basis providing mean (Kp) and uncertainty (sigma(K(p))) values for GFR.


RESULTS
In transplanted kidneys, average absolute variation of Kp was 6.4% +/- 4.8% (max = 16.6%). In native kidneys average absolute variation of Kp was 12.11% +/- 6.88% (max = 25.6%) for the right and 11.6% +/- 6% (max = 20.8%) for the left. Movement correction showed an average reduction of sigma(K(p)) of 6.9% +/- 6.6% (max = 21.4%) in transplanted kidneys, 30.9% +/- 17.6% (max = 60.8%) for the right native kidney, and 31.8% +/- 14% (max = 55.3%) for the left kidney.


CONCLUSIONS
The movement correction algorithm showed improved uncertainty on GFR computation for both native and transplanted kidneys despite different spatial resolution from the different MRI systems and different levels of signal-to-noise ratios on DCE-MRI.
Laboratory for Molecular and Functional Imaging: From Physiology to Therapy, UMR 5231 CNRS/Université Bordeaux 2, Bordeaux, France. baudouin@imf.u-bordeaux2.fr
Baudouin Denis
BD
de Senneville
Iosif Alexandru
IA
Mendichovszky
Sébastien
S
Roujol
Isky
I
Gordon
Chrit
C
Moonen
Nicolas
N
Grenier
D000328:Adult; D000465:Algorithms; D001331:Automation; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000502:physiology*; D016030:Kidney Transplantation; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009038:Motion; D012984:Software
D003287:Contrast Media; D019786:Gadolinium DTPA