Retinoblastoma: treatment and survival in Great Britain 1963 to 2002.
OBJECTIVE
This paper describes the treatment and survival of 1576 children with retinoblastoma in Great Britain diagnosed 1963-2002.


METHODS
Survival rates were analysed according to period of diagnosis and tumour laterality.


RESULTS
Survival was calculated by calendar period of diagnosis, 1963-1982 and 1983-2002. For both unilateral and bilateral retinoblastoma, survival improved between the two periods. The survival curves for the two periods were significantly different: for unilateral retinoblastoma p<0.00001, for bilateral p<0.01. For unilateral cases, the estimated 5-year survival rates rose from 85% for those diagnosed in 1963-1967 to 97% for those diagnosed in 1998-2002. The equivalent rates for bilateral cases were 88% and 100%.


CONCLUSIONS
Survival rates were already high at the start of the study period. They increased with changes in treatment regimens.
Childhood Cancer Research Group, University of Oxford, 57 Woodstock Road, Oxford OX2 6HJ, UK. angela.maccarthy@ccrg.ox.ac.uk
A
A
MacCarthy
J M
JM
Birch
G J
GJ
Draper
J L
JL
Hungerford
J E
JE
Kingston
M E
ME
Kroll
C A
CA
Stiller
T J
TJ
Vincent
M F G
MF
Murphy
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D015353:Eye Enucleation / Q000401:mortality; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012042:Registries / Q000706:statistics & numerical data; D019572:Retinal Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy; D012175:Retinoblastoma / Q000401:mortality / Q000473:pathology / Q000628:therapy; D016019:Survival Analysis; D015996:Survival Rate; D006113:United Kingdom / Q000453:epidemiology