Aluminum bioavailability from tea infusion.
The objective was to estimate oral Al bioavailability from tea infusion in the rat, using the tracer (26)Al. (26)Al citrate was injected into tea leaves. An infusion was prepared from the dried leaves and given intra-gastrically to rats which received concurrent intravenous (27)Al infusion. Oral Al bioavailability (F) was calculated from the area under the (26)Al, compared to (27)Al, serum concentration x time curves. Bioavailability from tea averaged 0.37%; not significantly different from water (F=0.3%), or basic sodium aluminum phosphate (SALP) in cheese (F=0.1-0.3%), but greater than acidic SALP in a biscuit (F=0.1%). Time to maximum serum (26)Al concentration was 1.25, 1.5, 8 and 4.8h, respectively. These results of oral Al bioavailability x daily consumption by the human suggest tea can provide a significant amount of the Al that reaches systemic circulation. This can allow distribution to its target organs of toxicity, the central nervous, skeletal and hematopoietic systems. Further testing of the hypothesis that Al contributes to Alzheimer's disease may be more warranted with studies focusing on total average daily food intake, including tea and other foods containing appreciable Al, than drinking water.
Department of Pharmaceutical Sciences, University of Kentucky Academic Medical Center, Lexington, KY 40536-0082, USA. ryokel@email.uky.edu
Robert A
RA
Yokel
Rebecca L
RL
Florence
D000535:Aluminum / Q000493:pharmacokinetics*; D000818:Animals; D001682:Biological Availability; D003627:Data Interpretation, Statistical; D004044:Dietary Proteins / Q000032:analysis; D008297:Male; D011868:Radioisotopes / Q000493:pharmacokinetics*; D051381:Rats; D011916:Rats, Inbred F344; D013054:Spectrophotometry, Atomic; D013662:Tea / Q000737:chemistry*
D004044:Dietary Proteins; D011868:Radioisotopes; D013662:Tea; D000535:Aluminum