[Correlation between characteristics of interictal epileptiform discharge and histopathological change in epilepsy patients with focal cortical dysplasia].
OBJECTIVE
To discuss the correlation between characteristics of interictal epileptiform discharge (IED) and histopathological changes in epilepsy patients with focal cortical dysplasia (FCD) in order to explore the epileptogenicity of various IED.


METHODS
Twenty-two consecutive patients suspected as with FCD who were to undergo epilepsy surgery received intracranial electrode implantation and long-term video-EEG monitoring before the resective surgery and the postoperative pathology proved the diagnosis of FCD. According the long-term EEG monitoring results, the IEDs were divided into four catalogs: isolated spike, slow repetitive spike, repetitive spike, and paroxysmal fast. The possible epileptogenic cortex with intense IED was resected in the operation to undergo histopathologic study and hemi-quantificational scoring of parvalbumin (PV) by immunocytochemistry.


RESULTS
The resected specimens of 20 cases were studied. There were not significant differences in the PV quantificational score between any 2 IED subtypes (F = 1.198, P = 0.342). However, the spike type had the highest PV score: 8.00, while the repetitive spike type had the lowest PV score: 5.60. On the other hand, FCD of different severity in terms of pathological changes tended to have different kind of IED.


CONCLUSIONS
Despite the insignificant differences between various kinds of IED, isolated spike has the highest PV scores meaning lower epileptogenicity. Slow repetitive spike, repetitive spike, and paroxysmal fast tend to occur in more severe FCD patients which mean a great possibility of epileptogenicity.
Cai
Li-Xin
LX
Beijing Institute of Functional Neurosurgery and Department of Pathology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing 100053, China.
Piao
Yue-Shan
YS
Liu
Lei
L
Lu
De-Hong
DH
Li
Yong-Jie
YJ
D000293:Adolescent; D000328:Adult; D002540:Cerebral Cortex / Q000473:pathology*; D002648:Child; D004569:Electroencephalography; D004827:Epilepsy / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D055815:Young Adult