[Preventive effects of 4 Se-enriched plants on rat stomach cancer induced by MNNG--3. Se accumulation and distribution in rats of different selenium resources for prevention of stomach cancer].
OBJECTIVE
To investigate the accumulation and distribution of blood and tissue Se in rats with long-term and high-dose of Se supplementation by four Se-enriched plants (Se-enriched garlic, Se-enriched broccoli, Se-enriched green kale and Se-enriched red kale) in the N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced stomach cancer model.


METHODS
Ninety rats were fed by basal diet for a week, divided equally into the control, MNNG and seven Se supplementation groups. Rats were daily given 15 mg/kg bw of MNNG for ten days except those in the control group, and rats in five Se-enriched plant treatment groups were daily given 150 or 300 microg Se/kg of bw of the plant suspension by gavage for 17 weeks. Rats were sacrificed at the end of 18th week, the Se contents of blood, red blood cell, plasma, liver, kidney, spleen, heart, brain and testicle were determined.


RESULTS
The Se contents of liver and kidney in rats supplemented by Se-enriched garlic were significantly lower than those in rats supplemented by Se-enriched broccoli and two Se-enriched kales, and the Se contents of red blood cell and spleen higher than those in rats supplemented by Se-enriched broccoli and two Se-enriched kales.


CONCLUSIONS
The data primarily shows that the differences of the accumulation and distribution of blood and tissue Se in rats are related to the supplemented plant Se components, and that lower Se accumulation of the liver and kidney in rats supplemented by Se-enriched garlic than by other plants may be one of Se safety indices of Se-enriched garlic.
Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijng 100050, China. wenjy6@126.com
Wenije
W
Yang
Jing
J
Chen
Weidong
W
Li
Xiaobin
X
Chen
D000818:Animals; D001937:Brassica / Q000737:chemistry*; D005737:Garlic / Q000737:chemistry; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008769:Methylnitronitrosoguanidine; D051381:Rats; D012643:Selenium / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology*; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D014018:Tissue Distribution
D008769:Methylnitronitrosoguanidine; D012643:Selenium