Infantile cortical hyperostosis (Caffey disease): a review.
OBJECTIVE
Face swelling in infants may have several causes including infantile cortical hyperostosis (Caffey disease), an inflammatory process with swelling of soft tissues and periosteal hyperostosis of some bones. New insights show that this self-limited condition is collagen I-related.


METHODS
Collagen I is the most important component of bone and dentine. We reviewed literature to lighten this new collagenopathy, the first one with a self-regressive course.


RESULTS
After describing a typical case and the clinical and radiologic features of the disease, we discuss the pathogenic pathways and management care for oral professionals.


CONCLUSIONS
Oral practitioners could be asked for differential diagnosis. Surgeons could be queried for surgical correction of the bony deformity, especially of facial and mandibular asymmetry.
Hôpital Necker, Paris, France. agnes.kamoun@yahoo.fr
Agnès
A
Kamoun-Goldrat
Martine
M
le Merrer
D024042:Collagen Type I / Q000235:genetics; D003937:Diagnosis, Differential; D006801:Humans; D006958:Hyperostosis, Cortical, Congenital / Q000000981:diagnostic imaging / Q000473:pathology*; D007223:Infant; D008334:Mandible / Q000000981:diagnostic imaging / Q000473:pathology; D008336:Mandibular Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D009154:Mutation; D011859:Radiography; D012075:Remission, Spontaneous; D013577:Syndrome
D024042:Collagen Type I