Plerixafor, a CXCR4 antagonist for the mobilization of hematopoietic stem cells.
Stem cells harvested from peripheral blood are the most commonly used graft source in hematopoietic stem cell transplantation. While G-CSF is the most frequently used agent for stem cell mobilization, the use of G-CSF alone results in suboptimal stem cell yields in a significant proportion of patients undergoing autologous transplantation. Plerixafor (AMD3100, Genzyme Corporation) is a bicyclam molecule that antagonizes the binding of the chemokine stromal cell-derived factor-1 (SDF-1) to its cognate receptor CXCR4. Plerixafor results in the rapid and reversible mobilization of hematopoietic stem cells into the peripheral circulation and is synergistic when combined with G-CSF. In clinical studies of autologous stem cell transplantation, the combination of plerixafor and G-CSF allows the collection of large numbers of stem cells in fewer apheresis sessions and can salvage those who fail G-CSF mobilization alone.
Uy
Geoffrey L
GL
Washington University School of Medicine, Division of Oncology, 660 S. Euclid Avenue, Campus Box 8007, St. Louis, Missouri 63110, USA. guy@im.wustl.edu
Rettig
Michael P
MP
Cashen
Amanda F
AF
D019380:Anti-HIV Agents / Q000494:pharmacology; D018952:Antigens, CD34 / Q000096:biosynthesis; D001596:Benzylamines; D054377:Chemokine CXCL12 / Q000378:metabolism; D002986:Clinical Trials as Topic; D000080027:Cyclams; D015195:Drug Design; D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D006571:Heterocyclic Compounds / Q000494:pharmacology*; D006689:Hodgkin Disease / Q000628:therapy; D006801:Humans; D008956:Models, Chemical; D019718:Receptors, CXCR4 / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D033581:Stem Cell Transplantation
D019380:Anti-HIV Agents; D018952:Antigens, CD34; D001596:Benzylamines; C527276:CXCR4 protein, human; D054377:Chemokine CXCL12; D000080027:Cyclams; D006571:Heterocyclic Compounds; D019718:Receptors, CXCR4; D016179:Granulocyte Colony-Stimulating Factor; C088327:plerixafor