Chemistry and pharmacology of collinin, active principle of Zanthoxylum spp.
Collinin is a geranyloxycoumarins isolated in small amounts from plants of the Rutaceae family. Synthetic schemes were recently developed allowing to handle collinin in sufficient quantities to put in evidence valuable biological effects. The aim of this review is to examine the phytochemical and pharmacological properties of this compound.
Dipartimento di Scienze del Farmaco, Università G. D'Annunzio, Chieti Scalo (CH), Italy. fepifano@unich.it
Francesco
F
Epifano
Salvatore
S
Genovese
Maria Carla
MC
Marcotullio
Massimo
M
Curini
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003374:Coumarins / Q000032:analysis / Q000737:chemistry*; D015195:Drug Design; D006801:Humans; D051379:Mice; D008813:Mice, Inbred ICR; D008956:Models, Chemical; D008517:Phytotherapy; D010936:Plant Extracts / Q000032:analysis / Q000737:chemistry*; D011817:Rabbits; D032106:Zanthoxylum / Q000378:metabolism*
D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D003374:Coumarins; D010936:Plant Extracts; C533975:collinin