Cytoplasmic signalling by the c-Abl tyrosine kinase in normal and cancer cells.
c-Abl is a non-receptor tyrosine kinase which is localized both in the nucleus and cytoplasm, and is involved in the regulation of cell growth, survival and morphogenesis. Although c-Abl nuclear function has been extensively studied, recent data also indicate an important role in cytoplasmic signalling through mitogenic and adhesive receptors. Here, we review the mechanisms by which growth factors promote cytoplasmic c-Abl activation and signalling and its function in the induction of DNA synthesis, changes in cell morphology and receptor endocytosis. The importance of de-regulated c-Abl cytoplasmic signalling in solid tumours is also discussed.
CRBM, CNRS UMR5237 UMI and II, 1919 route de Mende, 34293 Montpellier, France.
Audrey
A
Sirvent
Christine
C
Benistant
Serge
S
Roche
D000818:Animals; D002453:Cell Cycle; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D003593:Cytoplasm / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D016315:Proto-Oncogene Proteins c-abl / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
D016315:Proto-Oncogene Proteins c-abl