Venous thromboembolism in cancer patients undergoing major surgery.
BACKGROUND
Cancer patients undergoing major abdominal or pelvic surgery are at considerable risk of venous thromboembolism (VTE). The genesis of thromboses in malignancy is complicated, and reflects the interaction and derangement of multiple molecular pathways. Furthermore, the nature and location of the cancer, as well as the type surgery involved, are thought to affect the level of VTE risk. These considerations may therefore affect treatment decisions.


METHODS
We performed multiple Medline searches with terms including but not limited to VTE, cancer, surgery, abdominal, colorectal, unfractionated heparin (UFH), and low-molecular-weight heparin (LMWH) to identify reviews, meta-analyses, nonrandomized and randomized controlled trials, and clinical guidelines relating to management of VTE in patients with abdominal cancer.


RESULTS
VTE incidence in patients with malignancy varied according to cancer type, location, stage of progression, and the use of catheters and/or chemotherapy. Thromboprophylaxis with UFH or LMWH reduces the risk of developing VTE in these patients. However, LMWHs have a favorable risk-benefit profile over UFH and extending the duration prophylaxis may improve outcomes.


CONCLUSIONS
A number of recommendations can be made for the prevention of VTE in patients undergoing abdominal or pelvic surgery for cancer: (1) risk-stratify all patients according to defined evidence-based guidelines; (2) for most abdominal surgical oncology patients at risk, use of both an anticoagulant and mechanical means are indicated and beneficial; and (3) consider extended-duration prophylaxis (up to 28 days) in those patients with major abdominal/pelvic operations and impaired mobility, preferably with LMWH.
Osborne
Nicolas H
NH
Department of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Wakefield
Thomas W
TW
Henke
Peter K
PK
D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006801:Humans; D015201:Meta-Analysis as Topic; D009369:Neoplasms / Q000150:complications*; D017410:Practice Guidelines as Topic; D016032:Randomized Controlled Trials as Topic; D054556:Venous Thromboembolism / Q000209:etiology* / Q000517:prevention & control
D006495:Heparin, Low-Molecular-Weight