Vaspin serum concentrations in patients with carotid stenosis.
Obesity is associated with accelerated atherosclerosis. Adipokines may directly influence vessel wall homeostasis by influencing the function of endothelial cells, arterial smooth muscle cells, and modulating inflammation. Recently, visceral adipose tissue-derived serpin (vaspin) was identified as a novel adipokine related to obesity and its metabolic consequences. However, the regulation of vaspin serum concentrations in human atherosclerosis is unknown. We therefore assessed vaspin serum concentrations in 107 consecutive patients with carotid stenosis undergoing carotid endarterectomy (CEA) in relation to severity of atherosclerosis, measures of obesity and circulating markers of obesity and atherosclerosis. Vaspin serum concentrations were significantly lower in patients with carotid stenosis who experienced an ischemic event within 3 months before surgery compared to asymptomatic patients. However, circulating vaspin was not associated with measures of atherosclerosis severity as maximum percentage stenosis. Vaspin serum concentrations were indistinguishable before and after CEA. We found a significant correlation between vaspin and leptin serum concentrations supporting previous results that vaspin closely reflects body fat mass. In conclusion, our data show that low vaspin serum concentrations correlate with recently experienced ischemic events in patients with carotid stenosis despite the lack of an association between circulating vaspin and parameters of atherosclerosis severity.
Aust
Gabriela
G
Center of Surgery, Department of Visceral, Transplantation, Thoracic, and Vascular Surgery, Medical Faculty, University of Leipzig, Leipzig, Germany. ausg@medizin.uni-leipzig.de
Richter
Olaf
O
Rohm
Silvio
S
Kerner
Christiane
C
Hauss
Johann
J
Klöting
Nora
N
Ruschke
Karen
K
Kovacs
Peter
P
Youn
Byung-Soo
BS
Blüher
Matthias
M
D000368:Aged; D015901:Angiography, Digital Subtraction; D015415:Biomarkers / Q000097:blood; D002545:Brain Ischemia / Q000097:blood / Q000209:etiology* / Q000601:surgery; D016893:Carotid Stenosis / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery; D016894:Endarterectomy, Carotid; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood; D016014:Linear Models; D008297:Male; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood* / Q000150:complications; D011237:Predictive Value of Tests; D018570:Risk Assessment; D012307:Risk Factors; D015843:Serpins / Q000097:blood*; D012720:Severity of Illness Index; D016896:Treatment Outcome
D015415:Biomarkers; D020738:Leptin; C507339:SERPINA12 protein, human; D015843:Serpins