[Study of hepatitis C virus leukotropism by characterization of viral quasispecies in the liver transplantation setting].
Besides hepatocytes, representing the main replication site of hepatitis C virus, peripheral blood mononuclear cells also represent a crucial target for viral infection. Hepatitis C virus compartmentalization (i.e., non-random distribution) of viral variants between plasma and peripheral blood mononuclear cells, more frequently observed in liver transplant patients compared to non-transplanted patients, makes liver transplantation an interesting model for the analysis of hepatitis C leukotropism. This article aims to present, firstly, in clinical and biological features arguing favour of hepatitis C virus infection leukotropism and, secondly, to review current knowledge about compartmentalization between plasma and peripheral blood mononuclear cells, especially in the liver transplantation setting.
Schramm
F
F
Unité Inserm 748, 3, rue Koeberlé, 67000 Strasbourg, France. schrammfrederic@yahoo.fr
Moenne-Loccoz
R
R
Fafi-Kremer
S
S
Soulier
E
E
Royer
C
C
Weitten
T
T
Brignon
N
N
Ellero
B
B
Woehl-Jaegle
M-L
ML
Meyer
C
C
Wolf
P
P
Doffoel
M
M
Baumert
T-F
TF
Gut
J-P
JP
Stoll-Keller
F
F
Schvoerer
E
E
D001773:Blood Cells / Q000821:virology; D015331:Cohort Studies; D003449:Cryoglobulinemia / Q000821:virology; D016174:Hepacivirus / Q000235:genetics / Q000254:growth & development* / Q000302:isolation & purification / Q000502:physiology; D019698:Hepatitis C, Chronic / Q000150:complications / Q000601:surgery / Q000821:virology; D022781:Hepatocytes / Q000821:virology; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000821:virology*; D008099:Liver / Q000821:virology; D008103:Liver Cirrhosis / Q000209:etiology / Q000601:surgery / Q000821:virology; D016031:Liver Transplantation; D008228:Lymphoma, Non-Hodgkin / Q000821:virology; D009928:Organ Specificity; D018807:Polymorphism, Single-Stranded Conformational; D014759:Viral Envelope Proteins / Q000235:genetics; D014779:Virus Replication
D014759:Viral Envelope Proteins; C091015:glycoprotein E2, Hepatitis C virus
Etude du leucotropisme du virus de l'hépatite C par analyse des quasi-espèces virales dans le contexte de la transplantation hépatique.