[Advances on biosynthetic gene clusters of natural product from marine symbiotic microbe--a review].
Previous research has suggested that the true producers of numerous natural products isolated from marine invertebrates were the microbial epibiont and symbiont which are deemed as not-yet-cultivated microbe. Cloning of the biosynthetic genes responsible for a specific nature product not only provides direct genetic evidence of the origin of the compounds but also establishes the feasibility of mass production of the compounds by heterologous expression. This paper reviews the progresses on the biosynthetic gene clusters of nature products from the symbiotic bacteria including marine sponge, ascidian, bryozoan, deep-sea tube worm and deep-sea sediments.
Xu
Jing
J
Key Laboratory of Marine Genetic Resources, the Third Institute of Oceanography, State Oceanic Administration, Xiamen 361005, China. xvjv@163.com
Xu
Jun
J
D001419:Bacteria / Q000235:genetics* / Q000378:metabolism*; D001688:Biological Products / Q000096:biosynthesis*; D005798:Genes, Bacterial; D005810:Multigene Family; D009792:Oceans and Seas; D013559:Symbiosis
D001688:Biological Products