Structural organisation of cationic dioctadecyldimethyammonium bromide monolayers in presence of hyaluronic acid.
Langmuir monolayers of dioctadecyldimethyammonium bromide and its interaction with the natural mucopolysaccharide hyaluronic acid are studied using thermodynamic methods and X-ray diffraction at grazing incidence. The 2D crystalline lattice parameters of different phases are determined. The monolayer compressibility, the linear crystalline compressibility components and the thermoelastic expansion coefficient are evaluated. The biopolymer stabilises the monolayer structural properties, increases the collapse pressure and the correlation length of the 2D crystalline domains. The results show that this lipid has a potential for developing of stabilised drug delivery systems of anionic biopolymers like hyaluronic acid, oligomers and genes.
Ionov
R
R
LNPC, Université René Descartes, 45 rue des Saints Pères, 75270 Paris Cedex 06, France. r_ionov@hotmail.com
El-Abed
A
A
Goldmann
M
M
D000818:Animals; D002417:Cattle; D019245:Compressive Strength; D004548:Elasticity; D006820:Hyaluronic Acid / Q000737:chemistry*; D008567:Membranes, Artificial; D008956:Models, Chemical; D015394:Molecular Structure; D044367:Phase Transition; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D013499:Surface Properties; D013816:Thermodynamics; D014961:X-Ray Diffraction
D008567:Membranes, Artificial; D000644:Quaternary Ammonium Compounds; C015831:dimethyldioctadecylammonium; D006820:Hyaluronic Acid