Basics of particle therapy: introduction to hadrons.
With the arrival of 3-dimensional conformal radiation therapy and intensity modulated radiation therapy, radiation dose distributions in radiation oncology have improved dramatically over the past couple of decades. As part of a natural progression there recently has been a resurgence of interest in hadron therapy, specifically charged particle therapy, because of the even better dose distributions potentially achievable. In principle, using charged particle beams, radiation dose distributions can be achieved that surpass those possible with even the most sophisticated photon radiation delivery techniques. Certain charged particle beams might possess some biologic advantages in terms of tumor kill potential as well as this dosimetric advantage. The particles under consideration for such clinical applications all belong to the category of particles known as hadrons. This review introduces some of the elementary physics of the various hadron species previously used, currently used or being considered for future use in radiation oncology.
Welsh
James S
JS
Department of Human Oncology, University of Wisconsin-Madison, UW Cancer Center-Riverview, Wisconsin Rapids, WI 54494, USA. welsh@humonc.wisc.edu
D006801:Humans; D009369:Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D010315:Particle Accelerators; D017785:Photons / Q000627:therapeutic use*; D061766:Proton Therapy; D018787:Radiation Oncology / Q000295:instrumentation / Q000379:methods; D011882:Radiotherapy, High-Energy / Q000295:instrumentation* / Q000379:methods*; D011522:Protons
D011522:Protons