Sintokamides A to E, chlorinated peptides from the sponge Dysidea sp. that inhibit transactivation of the N-terminus of the androgen receptor in prostate cancer cells.
The new chlorinated peptides sintokamides A to E (1-5) have been isolated from specimens of the marine sponge Dysidea sp. collected in Indonesia. Their structures were elucidated by a combination of spectroscopic and single-crystal X-ray diffraction analyses. Sintokamide A (1) is an inhibitor of N-terminus transactivation of the androgen receptor in prostate cancer cells.
Sadar
Marianne D
MD
Genome Sciences Centre, B.C. Cancer Agency, 600 West 10th Avenue, Vancouver, BC, Canada V5Z 4E6.
Williams
David E
DE
Mawji
Nasrin R
NR
Patrick
Brian O
BO
Wikanta
Thamrin
T
Chasanah
Ekowati
E
Irianto
Hari Eko
HE
Soest
Rob Van
RV
Andersen
Raymond J
RJ
D000818:Animals; D045744:Cell Line, Tumor; D017606:Chlorine Compounds / Q000737:chemistry* / Q000494:pharmacology*; D047088:Dysidea / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008958:Models, Molecular; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry* / Q000494:pharmacology*; D011471:Prostatic Neoplasms / Q000235:genetics / Q000378:metabolism*; D011944:Receptors, Androgen / Q000235:genetics / Q000378:metabolism*; D015533:Transcriptional Activation / Q000187:drug effects
D017606:Chlorine Compounds; D010455:Peptides; D011944:Receptors, Androgen