Treatment of erosive vulvovaginal lichen planus with methotrexate.
We report the successful treatment of severe long-standing erosive vulvovaginal lichen planus in four adult female patients using 2.5-7.5 mg of oral methotrexate once weekly in conjunction with topical clobetasol dipropionate 0.05% ointment and tacrolimus 0.03-0.10% ointment. All cases experienced improvement in symptoms and healing of lesions within 4-8 weeks. Methotrexate was well tolerated and no adverse events have been observed in any of the patients at follow up 4-6 months later.
Department of Dermatology, Royal North Shore Hospital, St Leonards, New South Wales, Australia. nellyjang@hotmail.com
Nelly
N
Jang
Gayle
G
Fischer
D000328:Adult; D001003:Anal Canal; D003251:Constriction, Pathologic / Q000175:diagnosis / Q000209:etiology / Q000601:surgery; D003879:Dermatologic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008010:Lichen Planus / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D008727:Methotrexate / Q000627:therapeutic use*; D008875:Middle Aged; D011539:Pruritus Vulvae / Q000209:etiology; D016896:Treatment Outcome; D014623:Vaginal Diseases / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D014845:Vulvar Diseases / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*
D003879:Dermatologic Agents; D008727:Methotrexate