Interaction of apolipoproteins A-I and E in the regulation of DNA, RNA, and protein biosynthesis in cultured rat hepatocytes.
Experiments on hepatocyte culture showed that apolipoprotein A-I-tetrahydrocortisol complex increases the rate of DNA, RNA, and protein biosynthesis measured by radioactive label incorporation. Apolipoprotein E acted as competitor of the apolipoprotein A-I-tetrahydrocortisol complex and abolished biological activity of the latter. We hypothesize that this mechanism of regulation plays an important role in processes of intracellular regeneration and proliferation.
Panin
L E
LE
Institute of Biochemistry, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk.
Sumenkova
D V
DV
Knyazev
R A
RA
Polyakov
L M
LM
D000818:Animals; D016632:Apolipoprotein A-I / Q000502:physiology*; D001057:Apolipoproteins E / Q000502:physiology*; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis*; D005786:Gene Expression Regulation / Q000187:drug effects; D022781:Hepatocytes / Q000378:metabolism*; D008297:Male; D014176:Protein Biosynthesis / Q000187:drug effects / Q000502:physiology*; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D013760:Tetrahydrocortisol / Q000494:pharmacology
D016632:Apolipoprotein A-I; D001057:Apolipoproteins E; D012313:RNA; D013760:Tetrahydrocortisol; D004247:DNA