Macaflavanones A-G, prenylated flavanones from the leaves of Macaranga tanarius.
Phytochemical investigation of leaves of Macaranga tanarius resulted in the isolation of seven new prenylated flavanones, macaflavanones A-G (1-7), along with two known compounds, nymphaeol C (9) and the diterpene kolavenol. The structures of the new compounds were elucidated by means of a combination of spectroscopic methods and chemical conversion. The absolute structure of tanariflavanone B (8), isolated from the title plant, was also resolved. The cytotoxic activities of isolated flavanones were assayed using two cell lines, with macaflavanone G (7) being the most active compound in each case.
Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.
Shiori
S
Kawakami
Liva
L
Harinantenaina
Katsuyoshi
K
Matsunami
Hideaki
H
Otsuka
Takakazu
T
Shinzato
Yoshio
Y
Takeda
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification; D004354:Drug Screening Assays, Antitumor; D019665:Euphorbiaceae / Q000737:chemistry*; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007564:Japan; D007624:KB Cells; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D044950:Flavanones; C114792:kolavenol; C562280:nymphaeol C; C433626:tanariflavanone B