Pharmacokinetics of ivermectin in cats receiving a single subcutaneous dose.
Ivermectin is effective against ecto- and endoparasites. It is included in a plan of the Filariasis Division, Thailand for filariasis control and prevention by interrupting transmission of Brugia malayi-microfilariae from cat reservoirs to humans via mosquitoes. The pharmacokinetics of ivermectin in eight healthy cats receiving a single subcutaneous dose of 0.2mg/kg was investigated. Jugular blood samples were collected periodically for up to 30days after dosing. The serum ivermectin concentrations were measured by high performance liquid chromatography with fluorescence detection. The pharmacokinetic parameters (mean+/-S.D.) derived from one-compartment model analysis were as follows: T(max) 1.22+/-0.49day, C(max) 16.75+/-4.04ng/mL, k(ab) 2.62+/-1.86day(-1), t(1/2)(ab) 0.27+/-0.25day, k(el) 0.27+/-0.14day(-1), t(1/2)(el) 2.53+/-2.24day, V(d)/F 9.81+/-5.41L/kg, Cl/F 2.21+/-0.69L/kg/day and AUC(0-->infinity) 98.31+/-30.52ngday/mL. In conclusion, the pharmacokinetics of ivermectin in cats receiving a single dose of 0.2mg/kg by subcutaneous injection revealed a rapid absorption, high distribution, slow elimination and high possibility for the elimination of B. malayi-microfilariae from currently endemic regions.
Department of Pharmacology, Faculty of Science, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand. somsmorn.c@psu.ac.th
Somsmorn
S
Chittrakarn
Benjamas
B
Janchawee
Pritsana
P
Ruangrut
Supaporn
S
Kansenalak
Usa
U
Chethanond
Theerayot
T
Kobasa
Suwich
S
Thammapalo
D000042:Absorption; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D002415:Cats; D002851:Chromatography, High Pressure Liquid; D005260:Female; D007279:Injections, Subcutaneous; D007559:Ivermectin / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D015203:Reproducibility of Results
D000871:Anthelmintics; D007559:Ivermectin