Ferritin for the clinician.
Ferritin, a major iron storage protein, is essential to iron homeostasis and is involved in a wide range of physiologic and pathologic processes. In clinical medicine, ferritin is predominantly utilized as a serum marker of total body iron stores. In cases of iron deficiency and overload, serum ferritin serves a critical role in both diagnosis and management. Elevated serum and tissue ferritin are linked to coronary artery disease, malignancy, and poor outcomes following stem cell transplantation. Ferritin is directly implicated in less common but potentially devastating human diseases including sideroblastic anemias, neurodegenerative disorders, and hemophagocytic syndrome. Additionally, recent research describes novel functions of ferritin independent of iron storage.
Knovich
Mary Ann
MA
Section on Hematology and Oncology, Wake Forest University Health Sciences, Winston-Salem, NC 27157-1082, USA. mknovich@wfubmc.edu
Storey
Jonathan A
JA
Coffman
Lan G
LG
Torti
Suzy V
SV
Torti
Frank M
FM
D001052:Apoferritins / Q000097:blood / Q000737:chemistry / Q000378:metabolism; D005293:Ferritins / Q000097:blood* / Q000737:chemistry / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007501:Iron / Q000097:blood / Q000378:metabolism*; D019189:Iron Metabolism Disorders / Q000378:metabolism* / Q000628:therapy; D007704:Kininogens / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism*
D007704:Kininogens; D005293:Ferritins; D001052:Apoferritins; D007501:Iron