[Formulation optimization of panax notoginsenoside orally fast disintegration tablets].
OBJECTIVE
To optimize the formulation of panax notoginsenoside orally fast disintegrating tablets.


METHODS
Mannitol, microcrystalline cellulose (PH 102) and lactose 80 were used as diluent. A polynomial regression algorithm was used to evaluate the relationship between the controlling factor, compacting pressure and diluent ratio, and disintegration time, tensile strength of tablets. Optimum formulation and process parameters could be determined by contrast the contour plot of tensile strength to that of disintegration time.


RESULTS
The disintegration time and tensile strength of panax notoginsenoside oral disintegrating tablets were good, and the taste was satisfactory.


CONCLUSIONS
Panax notoginsenoside oral disintegrating tablets achieve the goal of design and this method can be fairly used in formulation screening.
Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Zhi
Z
Wang
Li
L
Wei
Ting
T
Chen
D002482:Cellulose / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D036145:Ginsenosides / Q000737:chemistry*; D007785:Lactose / Q000737:chemistry; D008353:Mannitol / Q000737:chemistry; D013607:Tablets / Q000737:chemistry*; D013718:Tensile Strength
D004365:Drugs, Chinese Herbal; D036145:Ginsenosides; C519374:Panax notoginseng extract; D013607:Tablets; D008353:Mannitol; D002482:Cellulose; D007785:Lactose; C109691:microcrystalline cellulose