[Biodegradation of tracheal carbon implant in animal experiment].
BACKGROUND
The radical treatment of tracheal stenosis comprises segmental resection and its reconstruction. The most successful type of reconstruction is the "end to end" technique. In cases with large tracheal defects (over 6 cm) this kind of reconstruction is impossible. From many years the adequate biomaterial is searched for the tracheal reconstruction. Most of the implanted biomaterials undergo biodegradation process.


OBJECTIVE
The aim of the study was to analyze the biodegradation process in carbon fibers of prosthesis implanted in tracheal defects in animal experiment.


METHODS
We studied the prosthesis implanted in tracheal defects in sheep. The prosthesis were built with composite biomaterial composed of carbon fibers and polisulfone. The observation period was 1, 2, 3, 4, 6, 8, 24 and 38 weeks. In the morphometric evaluations the breadth, curve width, fullness factor and mean grey level of carbon fibers were assessed.


RESULTS
The results showed that carbon fibers undergo progressively degradation in animal environment. The width gradually decreased. The mean grey level in the first three weeks decreased, but in the next period it increased. Conclusion. The carbon fibers of segmental tracheal prosthesis undergo gradually degradation process in biological environment expressed by decreasing of their dimensions connected with the lost of irregularities and changes of structure density.
Katedra i Oddział Kliniczny Laryngologii w Zabrzu.
Wojciech
W
Scierski
Grzegorz
G
Namysłowski
Jerzy
J
Nozyński
Lucyna
L
Turecka
Maciej
M
Misiołek
Eugeniusz
E
Czecior
Grazyna
G
Lisowska
Katarzyna
K
Mrówka-Kata
D000818:Animals; D001672:Biocompatible Materials / Q000378:metabolism*; D002247:Carbon Isotopes / Q000378:metabolism*; D003188:Composite Resins; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods; D019736:Prostheses and Implants; D012756:Sheep; D014135:Tracheal Stenosis / Q000601:surgery*
D001672:Biocompatible Materials; D002247:Carbon Isotopes; D003188:Composite Resins
Biodegradacja weglowego implantu tchawicy w eksperymencie zwierzecym.