Effects of resistance training in combination with coenzyme Q10 supplementation in patients with post-polio: a pilot study.
OBJECTIVE
Coenzyme Q10 supplementation leads to increased muscle metabolism in patients with post-polio syndrome. The aim of this study was to investigate the effect of resistance training in combination with oral supplementation with coenzyme Q10 in patients with post-polio syndrome regarding muscle strength and endurance as well as functional capacity and health-related quality of life.


METHODS
Parallel randomized, controlled, double-blind pilot study.


METHODS
A total of 14 patients (8 women and 6 men) with post-polio syndrome participated in a 12-week muscular resistance training, 3 days/week. The patients were randomized for oral supplementation with coenzyme Q10, 200 mg/day, or placebo. Measurements used were: sit-stand-sit test, timed up & go test, 6-minute walk test, muscle strength measurement by means of dynamic dynamometer and short-form (SF)-36 questionnaire.


RESULTS
Muscle strength, muscle endurance and quality of life regarding mental health increased statistically significantly in all 14 patients. There was no significant difference between the coenzyme Q10 and placebo groups regarding muscle strength, muscle endurance and quality of life.


CONCLUSIONS
There was no effect of coenzyme Q10 supplementation during resistance training on post-polio syndrome symptoms. Thus, supplementation with coenzyme Q10 has no beneficial effect on muscle function in patients with post-polio syndrome.
Department of Clinical Sciences, Karolinska Institutet, Division of Rehabilitation Medicine, Danderyds Hospital, Stockolm, Sweden.
Katarina
K
Skough
Charlott
C
Krossén
Susanne
S
Heiwe
Henning
H
Theorell
Kristian
K
Borg
D000284:Administration, Oral; D000368:Aged; D004311:Double-Blind Method; D005081:Exercise Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000502:physiology; D018482:Muscle, Skeletal / Q000378:metabolism; D017063:Outcome Assessment, Health Care; D010807:Physical Endurance / Q000502:physiology; D010865:Pilot Projects; D016262:Postpoliomyelitis Syndrome / Q000378:metabolism / Q000503:physiopathology / Q000534:rehabilitation*; D011788:Quality of Life; D011795:Surveys and Questionnaires; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D014815:Vitamins / Q000008:administration & dosage*; D016138:Walking / Q000502:physiology
D014815:Vitamins; D014451:Ubiquinone; C024989:coenzyme Q10