Endothelial dysfunction of cerebral and major arteries during chronic obstructive disease.
Vasomotor activity of the major and cerebral arteries was studied in mice with chronic obstructive pulmonary disease. Regional differences were revealed in the endothelium-dependent response of arteries. The development of chronic obstructive pulmonary disease was associated with a paradoxical response of the dilatational component of vasoregulation against the background of increased constrictive influences of the vascular endothelium in the major and cerebral vessels.
Vladivostok State Medical University.
B I
BI
Geltser
T A
TA
Brodskaya
V N
VN
Kotelnikov
I G
IG
Agafonova
P A
PA
Lukyanov
D000109:Acetylcholine; D000818:Animals; D002339:Carotid Arteries / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D020768:Middle Cerebral Artery / Q000503:physiopathology*; D005996:Nitroglycerin; D009638:Norepinephrine; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology*; D012039:Regional Blood Flow; D014661:Vasoconstriction / Q000502:physiology; D014664:Vasodilation / Q000502:physiology; D019323:omega-N-Methylarginine
D019323:omega-N-Methylarginine; D005996:Nitroglycerin; D000109:Acetylcholine; D009638:Norepinephrine