Cathepsin G increases MMP expression in normal human fibroblasts through fibronectin fragmentation, and induces the conversion of proMMP-1 to active MMP-1.
Eui Dong
ED
Son
Hyaekyoung
H
Kim
Hyunjung
H
Choi
So Hee
SH
Lee
Jin Young
JY
Lee
Sujung
S
Kim
B
B
Closs
Sera
S
Lee
Jin Ho
JH
Chung
Jae Sung
JS
Hwang
D000328:Adult; D000367:Age Factors; D000368:Aged; D000375:Aging; D002081:Buttocks; D056649:Cathepsin G; D002403:Cathepsins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D002478:Cells, Cultured; D004789:Enzyme Activation; D004792:Enzyme Precursors / Q000378:metabolism*; D005260:Female; D005347:Fibroblasts / Q000187:drug effects / Q000201:enzymology* / Q000528:radiation effects; D005353:Fibronectins / Q000378:metabolism*; D006801:Humans; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000235:genetics / Q000378:metabolism*; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D008875:Middle Aged; D010446:Peptide Fragments / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D012697:Serine Endopeptidases / Q000378:metabolism*; D015842:Serine Proteinase Inhibitors / Q000494:pharmacology; D012867:Skin / Q000166:cytology / Q000187:drug effects / Q000201:enzymology* / Q000528:radiation effects; D014466:Ultraviolet Rays
D004792:Enzyme Precursors; D005353:Fibronectins; D010446:Peptide Fragments; D012333:RNA, Messenger; D015842:Serine Proteinase Inhibitors; D002403:Cathepsins; D012697:Serine Endopeptidases; C534094:CTSG protein, human; D056649:Cathepsin G; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; C522360:MMP1 protein, human; D020781:Matrix Metalloproteinase 1