PASS-assisted exploration of antidepressant activity of 1,3,4-trisubstituted-beta-lactam derivatives.
Assisted by PASS predictions, the antidepressant activity of 1,3,4-trisubstituted monocyclic beta-lactams in seasonal affective disorders is described.
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab 147002, India.
Munish
M
Mittal
Rajesh K
RK
Goel
Gaurav
G
Bhargava
Mohinder P
MP
Mahajan
D000818:Animals; D000928:Antidepressive Agents / Q000737:chemistry* / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D019295:Computational Biology / Q000379:methods*; D018360:Crystallography, X-Ray; D003863:Depression / Q000188:drug therapy*; D015195:Drug Design; D006801:Humans; D051379:Mice; D008956:Models, Chemical; D008997:Monobactams / Q000737:chemistry*; D018079:Receptors, GABA / Q000378:metabolism; D016574:Seasonal Affective Disorder / Q000188:drug therapy*; D012701:Serotonin / Q000378:metabolism; D012984:Software
D000928:Antidepressive Agents; D008997:Monobactams; D018079:Receptors, GABA; D012701:Serotonin