Ultrasound promoted synthesis of substituted pyrazoles and isoxazoles containing sulphone moiety.
Novel pyrazoles and isoxazoles were synthesized from the reaction of the carbanions of 1-aryl-2-(phenylsulphonyl)-ethanone with different hydrazonyl halides and 1-aryl-2-bromo-2-hydroximinoethanone in ethanol, respectively. Reactions were carried out under silent and ultrasonic conditions. In general, it was found that ultrasound irradiations enable some reactions to occur which could not be carried out under silent condition in addition to improvement in reaction times. The products were obtained in high yields and their structures were determined by elemental analyses, spectral data and X-ray diffraction.
Department of Green Chemistry, National Research Centre, Dokki, Cairo 12622, Egypt.
Tamer S
TS
Saleh
Naglaa M
NM
Abd El-Rahman
D018360:Crystallography, X-Ray; D007202:Indicators and Reagents; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000528:radiation effects*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008958:Models, Molecular; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000528:radiation effects*; D012997:Solvents; D013055:Spectrophotometry, Infrared; D013450:Sulfones / Q000737:chemistry* / Q000528:radiation effects; D014465:Ultrasonics
D007202:Indicators and Reagents; D007555:Isoxazoles; D011720:Pyrazoles; D012997:Solvents; D013450:Sulfones