Towards novel S-DABOC inhibitors: synthesis, biological investigation, and molecular modeling studies.
A small family of S-DABO cytosine analogs (S-DABOCs) has been synthesized and biologically evaluated as HIV-1 inhibitor both on wild type (wt) and drug-resistant mutants leading to the identification of an interesting compound (5d). Molecular modeling studies have been finally performed in order to rationalize the results.
Radi
Marco
M
Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Siena, Via Alcide de Gasperi 2, I-53100 Siena, Italy.
Angeli
Lucilla
L
Franchi
Luigi
L
Contemori
Lorenzo
L
Maga
Giovanni
G
Samuele
Alberta
A
Zanoli
Samantha
S
Armand-Ugon
Mercedes
M
Gonzalez
Emmanuel
E
Llano
Anuska
A
Esté
Jose A
JA
Botta
Maurizio
M
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D003596:Cytosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular
D019380:Anti-HIV Agents; D003596:Cytosine