Factors influencing development of Down syndrome children in the first three years of life: Siriraj experience.
OBJECTIVE
To analyze factors influencing development of Down syndrome children in the first three years of life.


METHODS
A cross-sectional study was conducted in 100 Down syndrome (DS) children attending at the Genetics clinic, Department of Pediatrics, Siriraj Hospital between January 2002 and December 2005. All individuals were three to six years of age. The data was collected from January to December 2006, including general information and factors on the child and their families. The child developmental quotient (DQ) was evaluated by Capute Scales Cognitive Adaptive Test/Clinical Linguistic & Auditory Milestones Scale (CAT/CLAMS) at three years of age. Data were analyzed by descriptive statistic and multiple linear regression with the significant level at p-value < 0. 05.


RESULTS
The mean development quotient (DQ) was 63.78 +/- 11.25 (range 32-91) with the majority being mild developmental delay. The child and family factors contributing to developmental quotient (DQ) outcome were birthplace, congenital heart disease, age at the first genetic counseling, regular follow-up in the Genetics clinic, age at the first early stimulation program/speech training program, parental education/occupation, and family income. Only family income and age at the first speech-training program were found to be independently associated with developmental quotient (DQ) at the age of three years (p-value < 0.05).


CONCLUSIONS
Down syndrome is the most common genetic cause of mental retardation. Various factors contribute to developmental quotient (DQ) outcome but the most important factors are family income and age at the first speech-training program. Therefore, Down syndrome children with the above factors should be followed-up and monitored closely for the optimal long-term outcome.
Division of Medical Genetics, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. sipws@mahidol.ac.th
Pornswan
P
Wasant
Boonchai
B
Boonyawat
Samruay
S
Tritilanunt
Nithiwat
N
Vatanavicharn
Achara
A
Sathienkijakanchai
Pisanu
P
Ratanarak
Onanong
O
Malilum
Somporn
S
Liammongkolkul
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D002658:Developmental Disabilities; D004314:Down Syndrome / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D015995:Prevalence; D011594:Psychometrics; D012307:Risk Factors; D013785:Thailand / Q000453:epidemiology