Targeting NF-kappaB: a promising molecular therapy in inflammatory arthritis.
The nuclear factor-kappa B family of transcription factors is intimately involved in the regulation of the inflammatory responses that play a fundamental role in the damage of articular tissues. Thus, many studies have examined the important contributions of components of the NF-kappaB signaling pathways to the pathogenesis of various rheumatic diseases and their pharmacologic modulation. Currently available therapeutic agents including nonsteroidal anti-inflammatory drugs, corticosteroids, nutraceuticals, and disease-modifying antirheumatic drugs, as well as novel specific small-molecule inhibitors have been employed. In addition, promising nucleic acid-based strategies have shown encouraging results. However, further research will be needed before NF-kappaB-aimed strategies become an effective therapy for inflammatory arthritis.
Thomas Jefferson University, Jefferson Institute of Molecular Medicine, Philadelphia, Pennsylvania 19107, USA. jorge.roman-blas@jefferson.edu
Jorge A
JA
Roman-Blas
Sergio A
SA
Jimenez
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000378:metabolism* / Q000628:therapy; D001897:Boronic Acids / Q000627:therapeutic use; D000069286:Bortezomib; D006801:Humans; D007165:Immunosuppression Therapy; D007249:Inflammation; D051379:Mice; D016328:NF-kappa B / Q000276:immunology / Q000378:metabolism*; D019913:Nuclear Localization Signals / Q000378:metabolism; D009838:Oligodeoxyribonucleotides / Q000627:therapeutic use; D011719:Pyrazines / Q000627:therapeutic use; D051381:Rats; D015398:Signal Transduction
D000305:Adrenal Cortex Hormones; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001897:Boronic Acids; D016328:NF-kappa B; D019913:Nuclear Localization Signals; D009838:Oligodeoxyribonucleotides; D011719:Pyrazines; D000069286:Bortezomib