Renal dysfunction and tenofovir toxicity in HIV-infected patients.
Potentially nephrotoxic drugs are only 1 of several causes of renal dysfunction in HIV. Data from the period before the wide use of tenofovir show a variety of prerenal, renal, and obstructive causes of acute renal failure (ARF) in HIV outpatients. Results of clinical trials of tenofovir indicate a rate of ARF of approximately 1%, with observational cohort data indicating a somewhat higher rate. Thus, in evaluating patients with rising serum creatinine levels, including those receiving tenofovir, diagnostic efforts should go beyond discontinuation of potentially offending drugs. This article summarizes a presentation on renal dysfunction in HIV and renal toxicity of antiretroviral drugs made by Lynda A. Szczech, MD, MSCE, at an International AIDS Society-USA Continuing Medical Education course in Washington, DC, in May 2008. The original presentation is available as a Webcast at www.iasusa.org.
Szczech
Lynda A
LA
Duke University Medical Center, Durham, North Carolina, USA.
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000225:Adenine / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D063065:Organophosphonates / Q000627:therapeutic use* / Q000633:toxicity*; D000068698:Tenofovir
D063065:Organophosphonates; D000068698:Tenofovir; D000225:Adenine