A pilot study on level of blood vasoactive factors in prehypertensive and hypertensive patients.
A pilot study was conducted to investigate blood pressure level and vasoactive factors (VFs) among age- and sex-matched normotensive (NT), prehypertensive (PH), and hypertensive (EH) subjects. The results showed that angiotensin, arginine vasopressin, and endothelin were significantly higher, while adrenomedullin and calcitonin gene-related peptide were lower in the EH group than in the PH and NT groups. Nitric oxide synthase was not different among the three groups. There was a dose-response relationship between VFs and BP status. The results suggested that changes in blood VFs might be early warning signs of the development of prehypertension to hypertension, and important biomarkers for the early prevention of prehypertension.
Division of Hypertension, Beijing Institute of Heart, Lung, Blood Vessel Diseases, Beijing Anzhen Hospital, Attached to Capital University of Medical Sciences, Beijing, PR China.
Zuoguang
Z
Wang
Ya
Y
Liu
Jieling
J
Liu
Jie
J
Wen
Shaojun
S
Wen
Zhaosu
Z
Wu
D053607:Adrenomedullin / Q000097:blood; D000328:Adult; D000804:Angiotensin II / Q000097:blood; D001127:Arginine Vasopressin / Q000097:blood; D001794:Blood Pressure; D015740:Calcitonin Gene-Related Peptide / Q000097:blood; D016022:Case-Control Studies; D016232:Endothelins / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D019001:Nitric Oxide Synthase / Q000097:blood; D010865:Pilot Projects
C507862:ADM protein, human; D016232:Endothelins; D008055:Lipids; D000804:Angiotensin II; D001127:Arginine Vasopressin; D053607:Adrenomedullin; D019001:Nitric Oxide Synthase; D015740:Calcitonin Gene-Related Peptide