Feline thyroid carcinoma: diagnosis and response to high-dose radioactive iodine treatment.
This study reports the scintigraphy, histopathology, sole treatment with high-dose radioactive iodine and outcome of eight cases of feline thyroid carcinoma. Scintigraphic findings were variable and in 7/8 cases scintigraphic features could not reliably distinguish whether the thyroid tissue was malignant. Histopathology revealed typical criteria of malignancy in all cases, with mitotic activity described most frequently (7/8 cases), followed by infiltration of local tissues (4/8 cases). Cellular pleomorphism was infrequently observed. Single high-dose (1100MBq I(131)) radioiodine therapy was successful in 6/8 cases, with complete resolution of hyperthyroidism, and was associated with prolonged survival times (181-2381 days). Sole treatment with high-dose radioiodine is a safe and effective treatment for functional thyroid carcinoma. The prognosis for feline thyroid carcinoma successfully treated with radioiodine is good, with extended survival times commonly achieved.
Hibbert
Angie
A
The Feline Centre, Department of Clinical Veterinary Science, Division of Companion Animals, University of Bristol, Langford, Bristol, BS40 5DU, United Kingdom. angie.hibbert@bristol.ac.uk
Gruffydd-Jones
Tim
T
Barrett
Esther L
EL
Day
Michael J
MJ
Harvey
Andrea M
AM
D000818:Animals; D002371:Cat Diseases / Q000175:diagnosis* / Q000209:etiology / Q000532:radiotherapy*; D002415:Cats; D005260:Female; D006980:Hyperthyroidism / Q000209:etiology / Q000662:veterinary; D007457:Iodine Radioisotopes / Q000008:administration & dosage*; D008175:Lung Neoplasms / Q000556:secondary / Q000662:veterinary; D008297:Male; D011877:Radionuclide Imaging / Q000662:veterinary; D011795:Surveys and Questionnaires; D016019:Survival Analysis; D013961:Thyroid Gland / Q000000981:diagnostic imaging* / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000532:radiotherapy / Q000662:veterinary*; D016896:Treatment Outcome; D006113:United Kingdom
D007457:Iodine Radioisotopes