[Protective effect of injection of Danhong against acute myocardial ischemia in dogs].
OBJECTIVE
To investigate the protective effects of injection of Danhong against acute myocardial ischemia in dogs.


METHODS
The myocardial ischemia model were established by ligation of coronary artery in dogs. The degree of myocardial ischemia and the myocardial infarction size were observed before and after giving injection of Danhong. The serum creatine phosphokinase (CK) and lactate dehydrogenase (LDH) activities were also determined.


RESULTS
Injection of Danhong (1, 2, 4 g x kg(-1)) could significantly decreased the damage degree of myocardial ischemia, redused myocardial infarction size and also reduced the serum LDH and CK activities.


CONCLUSIONS
Injection of Danhong had protective action on myocardial ischemia.
Department of Pharmacology, Anhui Medical University, Hefei 230032, China. guoyanzx@yahoo.com.cn
Yan
Y
Guo
Liu-yi
LY
Dong
Zhi-wu
ZW
Chen
D000818:Animals; D003402:Creatine Kinase / Q000097:blood; D004285:Dogs; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000494:pharmacology*; D007267:Injections; D007770:L-Lactate Dehydrogenase / Q000097:blood; D009203:Myocardial Infarction / Q000097:blood / Q000150:complications / Q000473:pathology; D017202:Myocardial Ischemia / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000517:prevention & control*
D004365:Drugs, Chinese Herbal; C540581:danhong; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase