Elimination half-lives of polychlorinated biphenyl congeners in children.
The elimination kinetics of polychlorinated biphenyls (PCBs) in humans is difficult to assess in observational studies, because PCB exposure is never completely abolished. In a community with high dietary PCB exposures from whale blubber, we examined two groups of children with increased body burdens from breast-feeding. Follow-up was from ages 4.5 to 7.5 years (99 subjects) and 7 to 14 years (101 subjects). The calculations were performed by the use of structural equation models, with adjustment for body weight and dietary blubber intake as the main source of postnatal exposure. As a likely result of background exposures, apparent elimination half-lives were unexpectedly long when based on results from all cohort members. Subjects with exposures above the median and in the highest quartile showed half-lives of about 3-4 years for CB-138 and 4.5-5.5 years for CB-105 and CB-118; 6.5-7.5 years for CB-156, CB-170, and CB-187; and 7-9 years for CB-153 and CB-180. The longest half-lives correspond to elimination of the parent PCB solely with a daily fat excretion rate of 1-2 g, whereas shorter half-lives assume metabolic break-down.
Institute of Public Health, University of Southern Denmark, Winsløwparken 17, DK-5000 Odense, Denmark. Pgrand@hsph.harvard.edu
Philippe
P
Grandjean
Esben
E
Budtz-Jørgensen
Dana B
DB
Barr
Larry L
LL
Needham
Pal
P
Weihe
Birger
B
Heinzow
D000293:Adolescent; D000818:Animals; D049628:Body Size; D002648:Child; D015331:Cohort Studies; D003718:Denmark; D004032:Diet; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D011078:Polychlorinated Biphenyls / Q000097:blood*; D014907:Whales
D011078:Polychlorinated Biphenyls