Direct synthesis of chrysosplenol D.
An aldol condensation and an Algar-Flynn-Oyamada oxidative cyclization were key steps in the direct synthesis of chrysosplenol D, an efflux pump inhibitor that can potentiate the activity of commercially important antibiotics and antimalarials.
Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA. gakraus@iastate.edu
George
G
Kraus
Sudipta
S
Roy
D019306:Artemisia / Q000737:chemistry; D003500:Cyclization; D047309:Flavones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction
D047309:Flavones; C568008:chrysosplenol D