Ancestral T-box mutation is present in many, but not all, short-tailed dog breeds.
Dogs differ greatly in their morphological characteristics including various tail phenotypes. Congenitally short-tailed dogs are present in many breeds; however, the causative mutation located in the T-box transcription factor T gene (C189G) had only been described in the bobtailed Pembroke Welsh Corgis. We investigated here the presence of the T gene mutation in 23 other breeds (360 dogs, including 156 natural short tailed) in which natural bobtailed dogs exist. In the 17 breeds in which the C189G mutation was observed, there was a perfect correlation between this mutation and the short-tail phenotype. However, 6 breeds did not carry the known substitution or any other mutations in the T gene coding regions. No dogs were found to be homozygous for the C189G mutation, suggesting that the homozygous condition is lethal. In order to study the effect of the T gene mutation on litter size, we compared the number of puppies born from short-tailed parents to that born from long-tailed parents. In the Swedish Vallhund breed, we observed a 29% decrease in the litter size when both parents were short tailed. Given that the T gene mutation is not present in all breeds of short-tailed dog, there must be yet other genetic factors affecting tail phenotypes to be discovered.
Medical Biochemistry and Developmental Biology, Institute of Biomedicine, University of Helsinki, PO Box 63, 00014 Helsinki, Finland. marjo.hytonen@helsinki.fi
Marjo K
MK
Hytönen
Anaïs
A
Grall
Benoît
B
Hédan
Stéphane
S
Dréano
Samuel J
SJ
Seguin
Delphine
D
Delattre
Anne
A
Thomas
Francis
F
Galibert
Lars
L
Paulin
Hannes
H
Lohi
Kirsi
K
Sainio
Catherine
C
André
D000818:Animals; D001947:Breeding; D003433:Crosses, Genetic; D004285:Dogs; D019143:Evolution, Molecular; D005260:Female; D008098:Litter Size / Q000235:genetics; D009154:Mutation / Q000502:physiology; D010641:Phenotype; D010802:Phylogeny; D011247:Pregnancy; D020825:T-Box Domain Proteins / Q000235:genetics*; D013623:Tail / Q000033:anatomy & histology*
D020825:T-Box Domain Proteins