Quantitative genetics of renal function: tackling complexities of the eGFR phenotype in gene mapping studies.
The linkage approach to quantitative traits, such as estimated glomerular filtration rate (eGFR), has been utilized in several recent studies aimed at identification of susceptibility loci. However, the heterogeneity and complex architecture of the eGFR phenotype make the gene mapping efforts inherently difficult. Mottl and colleagues attempt to tackle this problem in their analysis of a unique family-based cohort of American Indians.
Columbia University, Department of Medicine, Division of Nephrology, New York, New York 10033, USA. Kk473@columbia.edu
Krzysztof
K
Kiryluk
D002874:Chromosome Mapping; D004777:Environment; D005192:Family Health; D008040:Genetic Linkage; D005919:Glomerular Filtration Rate / Q000235:genetics*; D006801:Humans; D007198:Indians, North American / Q000235:genetics; D007674:Kidney Diseases / Q000235:genetics*; D010641:Phenotype; D040641:Quantitative Trait Loci / Q000235:genetics; D019655:Quantitative Trait, Heritable