[T-cells regulate the immune-response in allergic rhinitis].
Allergic diseases show a broad variety of symptoms, depending on the type of allergen and the location where it interacts with the human body. Contact of allergens with the upper respiratory tract result in conjunctivitis or allergic rhinitis. Apart from antigenpresenting cells, T-cells do play an important role in this hypersensibility reaction. Due to the production and secretion of cytokines, T-lymphocytes induce and maintain the corresponding Th-immuneresponse. In addition to regulatory functions, T-cells have potential influence on the chronic progression of allergic inflammatory reactions of the nasal mucosa and are therefore interesting target cells for specific immunotherapy as well as corticosteroid treatment. This article shows the specific function of T-cells during allergic rhinitis and reveals the basics for understanding the mechanism of immunotherapy and chronification of inflammatory allergic diseases of the nasal mucosa.
Klimek
L
L
Zentrum für Rhinologie und Allergologie, Wiesbaden. Ludger.Klimek@HNO-Wiesbaden.de
Böttcher
I
I
D000281:Administration, Intranasal; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000938:Antigen-Presenting Cells / Q000276:immunology; D000941:Antigens / Q000276:immunology; D016207:Cytokines / Q000378:metabolism; D003888:Desensitization, Immunologic; D000939:Epitopes / Q000276:immunology; D006801:Humans; D009297:Nasal Mucosa / Q000276:immunology; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology* / Q000628:therapy; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D000305:Adrenal Cortex Hormones; D000941:Antigens; D016207:Cytokines; D000939:Epitopes
Die Regulation der Immunantwort bei der allergischen Rhinitis durch T-Lymphozyten.