Genetic characterization of Vga ABC proteins conferring reduced susceptibility to pleuromutilins in Staphylococcus aureus.
Retapamulin MICs of > or =2 microg/ml were noted for 6 of 5,676 S. aureus recent clinical isolates evaluated. The ABC proteins VgaAv and VgaA were found to be responsible for the reduced susceptibility to pleuromutilins exhibited by these six isolates.
Gentry
Daniel R
DR
Department of Microbiology, ID-CEDD, GlaxoSmithKline, Collegeville, Pennsylvania 19426, USA. dan.r.gentry@gsk.com
McCloskey
Lynn
L
Gwynn
Michael N
MN
Rittenhouse
Stephen F
SF
Scangarella
Nicole
N
Shawar
Ribhi
R
Holmes
David J
DJ
D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000494:pharmacology*; D004224:Diterpenes / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000235:genetics; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D011083:Polycyclic Compounds; D017422:Sequence Analysis, DNA; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D000097567:Pleuromutilins
D018528:ATP-Binding Cassette Transporters; D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D019086:Bridged Bicyclo Compounds, Heterocyclic; D004224:Diterpenes; D011083:Polycyclic Compounds; D000097567:Pleuromutilins; C075964:VgA protein, Staphylococcus aureus; C508887:retapamulin