Ploidy studies of pleomorphic adenomas and minor salivary gland carcinomas of the palate.
Ploidy studies of tumors are a diagnostic and prognostic aid. The aim of the present study was to evaluate the DNA content of palate aggressive pleomorphic adenomas (PA) and adenocarcinomas of the salivary glands. Twelve cases of salivary gland tumors of the palate were selected from the archives of the Oral Pathology Department, Faculty of Dentistry, University of Buenos Aires (1966-2001). Six cases corresponded to aggressive pleomorphic adenomas (PA) and the remaining six to adenocarcinomas (AD). Myxoid and epithelial areas of PA were evaluated. The epithelial areas of the most aggressive cases of PA exhibited a high DNA content. The myxoid areas of same cases of PA had a 2C ploidy level. The difference in ploidy values between the myxoid and epithelial areas of PA would suggest the presence of different cell populations. DNA content and the detection of aneuploidy would be prognostic aids in palate salivary gland carcinomas.
Brandizzi
Daniel
D
Laboratory of Research and Services in Microspectrophotometry (LANAIS-MEF - CONICET-CNEA). brandizzi@cnea.gov.ar
Carino
Silvia
S
Cabrini
Rómulo L
RL
D000230:Adenocarcinoma / Q000235:genetics*; D008949:Adenoma, Pleomorphic / Q000235:genetics*; D000782:Aneuploidy; D004273:DNA, Neoplasm / Q000235:genetics; D004847:Epithelial Cells / Q000473:pathology; D006801:Humans; D009092:Mucous Membrane / Q000473:pathology; D009361:Neoplasm Invasiveness / Q000235:genetics*; D021362:Palate, Hard / Q000473:pathology*; D012189:Retrospective Studies; D012468:Salivary Gland Neoplasms / Q000235:genetics*; D012470:Salivary Glands, Minor / Q000473:pathology
D004273:DNA, Neoplasm