[Clinical and cytogenetic features of hematologic malignancies associated with acquired trisomy 21].
OBJECTIVE
To investigate the association between trisomy 21 abnormalities and the clinical and cytogenetic features of hematologic malignancies.


METHODS
Chromosome preparations were made on bone marrow cells by using direct method and/or unstimulated short-term cultures. Karyotypes were analyzed by R-banding.


RESULTS
Thirteen patients (1.5%) with acute myeloid leukemia (AML) including 6 cases of M5b, 8 (2.2%) with acute lymphoblastic leukemia (ALL) and 4 cases with other hematologic malignancies had acquired trisomy 21, and in 13 patients it occurred as the sole cytogenetic abnormality. The remaining had combination with other abnormalities. The median survival for the 19 patients with trisomy 21 was 9 months.


CONCLUSIONS
M5b was the major type in AML with sole acquired trisomy 21.Trisomy 21 as the sole abnormality appeared to have a poor prognosis.
Institute of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, P.R. China.
Huanping
H
Wang
Wanmao
W
Ni
Zhimei
Z
Chen
Jiyu
J
Lou
Huan
H
Xu
Yunbiao
Y
Yu
Wenbin
W
Qian
Jie
J
Jin
D000293:Adolescent; D000328:Adult; D000368:Aged; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D005500:Follow-Up Studies; D019337:Hematologic Neoplasms / Q000150:complications* / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000235:genetics / Q000473:pathology; D015996:Survival Rate