Quantitative PCR assay used to monitor serum Trichosporon asahii DNA concentrations in disseminated trichosporonosis.
A bone marrow transplant recipient with disseminated trichosporonosis was successfully treated with voriconazole. Quantitative PCR assay results for Trichosporon asahii DNA in the sera were well correlated with the patient's clinical course. Based on the in vitro susceptibility test, the organism was susceptible to voriconazole.
Tsuji
Yoichiro
Y
Department of Pediatrics, National Defense Medical College, Tokorozawa, Saitama, Japan. ytsuji@ndmc.ac.jp
Tokimatsu
Issei
I
Sugita
Takashi
T
Nozaki
Masatoshi
M
Kobayashi
Daisuke
D
Imai
Kohsuke
K
Kogawa
Kazuhiro
K
Nonoyama
Shigeaki
S
D000293:Adolescent; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use; D000946:Antigens, Fungal / Q000097:blood; D016026:Bone Marrow Transplantation; D004271:DNA, Fungal / Q000097:blood*; D006086:Graft vs Host Disease / Q000150:complications; D006801:Humans; D016867:Immunocompromised Host; D007841:Latex Fixation Tests; D008297:Male; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D016133:Polymerase Chain Reaction; D011134:Polysaccharides / Q000097:blood; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications; D011743:Pyrimidines / Q000627:therapeutic use; D014230:Triazoles / Q000627:therapeutic use; D014250:Trichosporon / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D065819:Voriconazole
D000935:Antifungal Agents; D000946:Antigens, Fungal; D004271:DNA, Fungal; D011134:Polysaccharides; D011743:Pyrimidines; D014230:Triazoles; C027478:glucuronoxylomannan; D065819:Voriconazole