Neural correlates of the Clock Drawing Test performance in Alzheimer's disease: a FDG-PET study.
OBJECTIVE
This study aimed to identify the functional neuroanatomical correlates of impaired clock drawing test (CDT) performance in patients with Alzheimer's disease (AD).


METHODS
The CDT was administered to 71 patients with AD, and regional cerebral glucose metabolism (rCMglc) was measured by positron emission tomography (PET). Correlations between CDT scores and rCMglc were examined on a voxel-by-voxel basis.


RESULTS
Significant positive correlations were found between CDT performance and rCMglc in the right inferior parietal lobule and right posterior cingulate cortex.


CONCLUSIONS
These results provide the first PET evidence that poor CDT performance in patients with AD is closely related to the functional decline in the right hemisphere, especially the right parietal cortex.
Lee
Dong Young
DY
Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea.
Seo
Eun Hyun
EH
Choo
Il Han
IH
Kim
Shin Gyeom
SG
Lee
Jae Sung
JS
Lee
Dong Su
DS
Jhoo
Jin Hyeong
JH
Kim
Ki Woong
KW
Youn
Jong Choul
JC
Woo
Jong Inn
JI
D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000523:psychology*; D001923:Brain Chemistry / Q000502:physiology; D001931:Brain Mapping; D003627:Data Interpretation, Statistical; D005260:Female; D019788:Fluorodeoxyglucose F18; D007839:Functional Laterality / Q000502:physiology; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005947:Glucose