Liquid chromatography-time-of-flight mass spectrometry analysis of 1-(2-chloroethoxy)-2-[(2-chloroethyl)thio] ethane and related compounds: separation of an eleven component mixture.
A method of separation for an eleven component mixture comprised of 1-(2-chloroethoxy)-2-[(2-chloroethyl)thio] ethane (4) and its derivatives has been developed using LC-time-of-flight-MS. All analytical figures of merit for compounds 1-11 have been determined. Compound 4 was examined in a substrate extraction study consisting of different sand and soil matrices, and a hydrolysis study of 4 on sand revealed an extremely complex degradation pathway which appeared to be concentration dependent. Substrate extraction and hydrolysis results where compared with sulfur mustard (HD).
Research and Technology Directorate, U.S. Army Edgewood Research, Edgewood Chemical Biological Center (ECBC), Aberdeen Proving Ground, MD 21010-5424, USA.
Mark D
MD
Winemiller
Sue Y
SY
Bae
D002619:Chemical Warfare Agents / Q000032:analysis; D002853:Chromatography, Liquid / Q000295:instrumentation / Q000379:methods*; D006843:Hydrocarbons, Chlorinated / Q000032:analysis*; D006868:Hydrolysis; D013058:Mass Spectrometry / Q000295:instrumentation / Q000379:methods*; D009151:Mustard Gas / Q000031:analogs & derivatives* / Q000032:analysis*; D012680:Sensitivity and Specificity; D012987:Soil / Q000032:analysis
C533976:1-(2-chloroethoxy)-2-((2-chloroethyl)thio) ethane; D002619:Chemical Warfare Agents; D006843:Hydrocarbons, Chlorinated; D012987:Soil; D009151:Mustard Gas