Interaction of apolipoproteins A-I and E in the regulation of DNA, RNA, and protein biosynthesis in cultured rat hepatocytes.
Experiments on hepatocyte culture showed that apolipoprotein A-I-tetrahydrocortisol complex increases the rate of DNA, RNA, and protein biosynthesis measured by radioactive label incorporation. Apolipoprotein E acted as competitor of the apolipoprotein A-I-tetrahydrocortisol complex and abolished biological activity of the latter. We hypothesize that this mechanism of regulation plays an important role in processes of intracellular regeneration and proliferation.
Institute of Biochemistry, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk.
L E
LE
Panin
D V
DV
Sumenkova
R A
RA
Knyazev
L M
LM
Polyakov
D000818:Animals; D016632:Apolipoprotein A-I / Q000502:physiology*; D001057:Apolipoproteins E / Q000502:physiology*; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis*; D005786:Gene Expression Regulation / Q000187:drug effects; D022781:Hepatocytes / Q000378:metabolism*; D008297:Male; D014176:Protein Biosynthesis / Q000187:drug effects / Q000502:physiology*; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D013760:Tetrahydrocortisol / Q000494:pharmacology
D016632:Apolipoprotein A-I; D001057:Apolipoproteins E; D012313:RNA; D013760:Tetrahydrocortisol; D004247:DNA