Impairments of prehension kinematics and grasping forces in patients with cerebellar degeneration and the relationship to cerebellar atrophy.
OBJECTIVE
This study established the relationship between kinematic and grip force parameters in prehension tasks, disease severity and cerebellar atrophy in patients with cerebellar degeneration.


METHODS
Prehension was tested in a condition during which the hand reached out, grasped, and lifted an object. Task complexity was modified by limiting the transport component to a single-joint movement, and introducing a bimanual condition.


RESULTS
Compared to controls the cerebellar patients showed disturbances in hand transport, in hand shaping and the most pronounced in time to peak grip force and the grip/load force coupling. Task-dependent changes did not differ between groups. Ataxia scores revealed significant correlations with hand transport and shaping measures only. Ataxia subscores correlated with volume reduction of appropriate longitudinal cerebellar zones. Volume reduction of the intermediate zone was associated with grip force coordination deficits.


CONCLUSIONS
Results indicate that the cerebellum may have a more general role in motor control of grasping independent of task complexity. Temporal and coordinative measures of grip force appear to be most useful to assess the severity of grasping deficits in patients with cerebellar degeneration not detectable by clinical ataxia scales.


CONCLUSIONS
To assess the severity and course of cerebellar disease grip force control in a standard prehension task is a sensitive quantitative measure.
Department of Neurology, University of Duisburg-Essen, Hufelandstrasse 55, 45147 Essen, Germany. barbara.brandauer@uni-duisburg-essen.de
B
B
Brandauer
J
J
Hermsdörfer
A
A
Beck
V
V
Aurich
E R
ER
Gizewski
C
C
Marquardt
D
D
Timmann
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001284:Atrophy / Q000473:pathology; D001696:Biomechanical Phenomena / Q000502:physiology; D002531:Cerebellum / Q000098:blood supply / Q000473:pathology*; D005260:Female; D018737:Hand Strength / Q000502:physiology*; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D019957:Motor Skills Disorders / Q000209:etiology*; D009068:Movement; D010100:Oxygen / Q000097:blood; D012720:Severity of Illness Index; D013132:Spinocerebellar Degenerations / Q000473:pathology* / Q000503:physiopathology*; D013997:Time Factors
D010100:Oxygen