pH controlled release of chromone from chromone-Fe3O4 nanoparticles.
We report a new strategy for coupling chromone to Fe3O4 nanoparticles. The chromone-Fe3O4 NP conjugate shows a dramatic increase in chromone solubility in cell culture medium from less than 2.5 to 633 microg/ml, leading to the enhanced chromone uptake by HeLa cells. Chromone can be released at low pH and as a result, the chromone-Fe3O4 conjugate is much more efficient in inhibiting the HeLa cell proliferation. Such chromone-Fe3O4 NPs are promising as a powerful multifunctional delivery system for both chromone-based diagnostic and therapeutic applications.
Department of Chemistry, Brown University, Providence, Rhode Island 02912, USA.
Baodui
B
Wang
Chenjie
C
Xu
Jin
J
Xie
Zhengyin
Z
Yang
Shouheng
S
Sun
D000447:Aldehydes / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry; D002867:Chromones / Q000737:chemistry*; D003470:Culture Media; D004298:Dopamine / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D012995:Solubility
D000447:Aldehydes; D001672:Biocompatible Materials; D002867:Chromones; D003470:Culture Media; D011092:Polyethylene Glycols; D004298:Dopamine; D052203:Ferrosoferric Oxide