[Effect of the nutritional recovery on the concentration of Interleukin-2 in severely malnourished children].
The severely malnourished child has dysfunction of the immune response that may increase the risk of morbidity or mortality due to infectious diseases, therefore, the purpose of this study was to demonstrate the effect of intensive nutritional support on the cellular and serum concentration of IL-2 and CD4+, as well as CD8+ T cells in children with severe protein energy malnutrition. A clinical assay was carried out in a tertiary care hospital. 10 severely malnourished children < 48 months of age who received formula without lactose via enteral feeding for two weeks and ad libitum for an additional two weeks were included. Cellular and serum concentrations of IL-2 and the subpopulation of CD4+ and CD8+ were obtained. A control group (n = 13) was included. A paired student t test for initial-final determinations and the Mann-Whitney Test for comparison with control group were used, and null hypothesis was rejected with a p value < 0.05. There was a noteworthy increase in the comparison between the initial vs. final percentage of the cellular expression of IL-2 (p < 0.001) and in the serum concentration of IL-2 (p = 0.001). Therefore, four weeks of nutritional recovery significantly restored the production of IL-2, independently of the nutrients involved in the process, although, the rate of restoration seems to depend on the severity of the children primary PEM.
Instituto de Nutrición Humana & Laboratorio de Inmunología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara México.
Edgar
E
Vásquez-Garibay
Katja
K
Stein
Concepción
C
Méndez-Estrada
Elías
E
Pérez-Becerra
Enrique
E
Romero-Velarde
Isabel
I
Ibarra Gutiérrez
Miguel Angel
MA
Ortiz Ortega
Trinidad
T
García Iglesias
D016516:CD4-CD8 Ratio; D016022:Case-Control Studies; D002675:Child, Preschool; D004750:Enteral Nutrition; D005260:Female; D006801:Humans; D007223:Infant; D041943:Infant Formula / Q000008:administration & dosage*; D007376:Interleukin-2 / Q000097:blood* / Q000276:immunology; D008297:Male; D011502:Protein-Energy Malnutrition / Q000097:blood / Q000276:immunology* / Q000628:therapy; D012720:Severity of Illness Index; D013997:Time Factors
D007376:Interleukin-2
Efecto de la recuperación nutricia sobre la concentración de Interleucina-2 en niñios con desnutrición grave.