Transient increases of glutamic acid decarboxylase 67 immunoreactivity and its protein levels in the somatosensory cortex after transient cerebral ischemia in gerbils.
In this study, we investigated changes in glutamic acid decarboxylase 67 (GAD67) immunoreactivity and its protein levels in the gerbil somatosensory cortex after ischemia/reperfusion. GAD67 immunoreactivity was significantly increased in layers III and V of the somatosensory cortex 12 hr after ischemia/reperfusion. Thereafter, GAD67 immunoreactivity was decreased with time after ischemia/reperfusion. GAD67 immunoreactivity in the somatosensory cortex 4 days after ischemia/reperfusion was similar to that in the sham-operated group. In addition, GAD67 protein levels were also significantly increased 12 hr after transient forebrain ischemia. These results suggest that the transient increase of GAD67 immunoreactivity in layers III and V may be associated with responses to transient ischemia-induced neuronal damage.
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, South Korea.
In Koo
IK
Hwang
Ki-Yeon
KY
Yoo
Hua
H
Li
Ok Kyu
OK
Park
Choong Hyun
CH
Lee
Jung Hoon
JH
Choi
Dae Young
DY
Kwon
Moo-Ho
MH
Won
D000704:Analysis of Variance; D000818:Animals; D015153:Blotting, Western; D002545:Brain Ischemia / Q000378:metabolism*; D005849:Gerbillinae; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D007150:Immunohistochemistry; D013003:Somatosensory Cortex / Q000378:metabolism*
D005968:Glutamate Decarboxylase