Trans-selective asymmetric aziridination of diazoacetamides and N-Boc imines catalyzed by axially chiral dicarboxylic acid.
Axially chiral dicarboxylic acid (R)-1d catalyzed reaction of diazoacetamides and N-Boc imines provided a novel organocatalytic means for the formation of enantiomerically enriched N-Boc protected trans aziridines.
Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.
Takuya
T
Hashimoto
Nanase
N
Uchiyama
Keiji
K
Maruoka
D000447:Aldehydes / Q000737:chemistry; D001388:Aziridines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D018360:Crystallography, X-Ray; D003979:Diazonium Compounds / Q000737:chemistry*; D003998:Dicarboxylic Acids / Q000737:chemistry; D005563:Formic Acid Esters / Q000737:chemistry; D006860:Hydrogen Bonding; D007097:Imines / Q000737:chemistry*
D000447:Aldehydes; D001388:Aziridines; D003979:Diazonium Compounds; D003998:Dicarboxylic Acids; D005563:Formic Acid Esters; D007097:Imines; C000345:t-butyloxycarbonyl group; C011752:diazoacetamide