Prognostic factors in malignancy of the minor salivary glands.
BACKGROUND
The purpose of this study was to identify prognostic factors associated with minor salivary gland malignancies.


METHODS
This was a retrospective study of 171 patients. Statistical analysis of both clinical and pathological parameters with survival outcomes was performed.


RESULTS
Adenoid cystic carcinoma (46.8%), mucoepidermoid carcinoma (22.8%), and adenocarcinoma (18.7%) were the most common pathologies. The most frequent sites of primary tumor were in the oral cavity (44.4%) and nasal cavity (40.4%). The 5-year and 10-year overall survivals were 73.8% and 58.1%. Disease-specific survivals (DSS) were 78.2% and 66.7% and disease-free survivals (DFS) were 64.8% and 47.5%, respectively. Local recurrence rate was 26.9%, regional recurrence 7%, and distant failure was 18.7%. The grade of tumor was the only factor associated with DSS on multivariate analysis.


CONCLUSIONS
Overall and DSS of minor salivary gland malignancies were good. Surgery, either alone or in combination with radiation, was an efficacious treatment modality. High-grade tumors were associated with worse DSF.
Department of Otolaryngology-Head and Neck Surgery, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada.
Kwok Seng
KS
Loh
Emma
E
Barker
Guillem
G
Bruch
Brian
B
O'Sullivan
Dale H
DH
Brown
David P
DP
Goldstein
Ralph W
RW
Gilbert
Patrick J
PJ
Gullane
Jonathan C
JC
Irish
D000230:Adenocarcinoma / Q000401:mortality*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003528:Carcinoma, Adenoid Cystic / Q000401:mortality*; D018277:Carcinoma, Mucoepidermoid / Q000401:mortality*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000473:pathology; D015999:Multivariate Analysis; D009296:Nasal Cavity / Q000473:pathology; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D011379:Prognosis; D012189:Retrospective Studies; D012468:Salivary Gland Neoplasms / Q000401:mortality*; D012470:Salivary Glands, Minor / Q000473:pathology; D016019:Survival Analysis; D055815:Young Adult