Chalcones and their potential role in inflammation.
Chalcones are a group of phenolic compounds which possess a wide variety of cytoprotective and modulatory functions. They have been shown to possess antioxidant, oxygen scavenging and anti-inflammatory properties in a variety of experimental systems and can trigger the intracellular cascade of protective pathways offering a promising stratagem for therapeutic applications. In this research we will review the anti-inflammatory effect of chalcone derivatives and new approaches.
Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, Greece.
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Kontogiorgis
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Mantzanidou
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Hadjipavlou-Litina
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000975:Antioxidants / Q000378:metabolism; D047188:Chalcones / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D016166:Free Radical Scavengers; D006801:Humans; D007249:Inflammation; D007975:Leukotriene B4 / Q000737:chemistry; D008954:Models, Biological; D008956:Models, Chemical; D009504:Neutrophils / Q000378:metabolism; D010100:Oxygen / Q000737:chemistry; D019800:Phenol / Q000737:chemistry
D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D047188:Chalcones; D016166:Free Radical Scavengers; D007975:Leukotriene B4; D019800:Phenol; D010100:Oxygen