Effectiveness of sequential combined treatment in comparison with treatment as usual in preventing relapse in alcohol dependence.
OBJECTIVE
The aim of this study was to compare the effectiveness of the sequential combined treatment (SCT) and treatment as usual (TU) in relapse prevention in a sample of alcohol-dependent patients, during 180 days of outpatient treatment.


METHODS
209 alcohol-dependent patients who could attend with an informant adult were randomized to either TU or SCT. The primary outcome measure was time to first relapse, defined as the consumption of any amount of alcohol during the 180 days of follow-up. Secondary outcome measures included maximum duration of continuous abstinence (MDCA), cumulative abstinence duration (CAD), quality of life (ARPQ) and blood test markers of alcohol consumption.


RESULTS
The SCT approach was more effective than TU. The Kaplan-Meier abstinent proportion at the end of the 180 days was 78% for the SCT group and 59% for the TU group (P<0.01). The mean time to first relapse was 150 days for SCT and 123 days for TU (P<0.01). The relative risk reduction of relapse was 62% for SCT after adjustment in multiple Cox regression (P<0.01). SCT had more MDCA (P<0.05) and more CAD (P<0.05). Therapy sessions lasted slightly longer for SCT than TU (mean 13 min versus 10 min).


CONCLUSIONS
SCT can result in better outcomes than TU in the outpatient treatment of alcohol dependence.
Neto
Domingos
D
Princípio-Actividades Médicas, Rua Sargento José Paulo dos Santos No. 25, 1800-330 Lisboa, Portugal. dnetoster@gmail.com
Lambaz
Rita
R
Aguiar
Pedro
P
Chick
Jonathan
J
D000077443:Acamprosate; D000328:Adult; D000437:Alcoholism / Q000097:blood / Q000188:drug therapy / Q000517:prevention & control*; D014151:Anti-Anxiety Agents / Q000008:administration & dosage*; D000928:Antidepressive Agents / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D055502:Secondary Prevention; D013654:Taurine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D013695:Temperance
D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D013654:Taurine; D000077443:Acamprosate