Primary signet ring cell carcinoma of the appendix: a rare case report and our 18-year experience.
Primary adenocarcinoma of the appendix is a rare malignancy that constitutes < 0.5% of all gastrointestinal neoplasms. Moreover, primary signet ring cell carcinoma of the appendix is an exceedingly rare entity. We have encountered 15 cases of primary appendiceal cancer among 3389 patients who underwent appendectomy over the past 18 years. In the present report, we describe a rare case of primary signet ring cell carcinoma of the appendix with ovarian metastases and unresectable peritoneal dissemination occurring in a 67-year-old female patient. She underwent appendectomy and bilateral salpingo-oophorectomy with a laparoscopy procedure. She then received palliative systemic chemotherapy with 12 cycles of oxaliplatin, 5-flurorouracil, and leucovorin (FOLFOX-4). The patient currently is well without progression of disease 12 mo after beginning chemotherapy.
Department of Internal Medicine, Catholic University, Banpo-dong 505, Seocho-gu, Seoul 137-701, South Korea.
Yoon-Ho
YH
Ko
Chan-Kwon
CK
Jung
Soon-Nam
SN
Oh
Tae-Hee
TH
Kim
Hye-Sung
HS
Won
Jin-Hyoung
JH
Kang
Hyung-Jin
HJ
Kim
Won-Kyung
WK
Kang
Seong-Taek
ST
Oh
Young-Seon
YS
Hong
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001062:Appendectomy; D001063:Appendiceal Neoplasms / Q000473:pathology* / Q000628:therapy; D018279:Carcinoma, Signet Ring Cell / Q000556:secondary* / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000556:secondary* / Q000628:therapy; D010052:Ovariectomy; D010534:Peritoneal Neoplasms / Q000556:secondary* / Q000628:therapy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome