Effect of a successful intensive lifestyle program on insulin sensitivity and glucose tolerance in obese youth.
OBJECTIVE
To evaluate the impact on glucose metabolism of a lifestyle program (the Yale Bright Bodies Program) for obese children.


METHODS
Thirteen Bright Bodies and ten clinic-care control subjects who were part of a large randomized clinical trial had 75-g oral glucose tolerance tests at the beginning and end of the 12-month study.


RESULTS
Bright Bodies subjects had significantly greater decreases in weight, BMI, and body fat than clinic-care subjects, and the Bright Body subjects' changes in body composition were accompanied by marked improvements in insulin sensitivity (P = 0.009) and glucose tolerance (P = 0.04).


CONCLUSIONS
An intensive lifestyle program that successfully reduces body weight and body fat can markedly improve insulin sensitivity and glucose metabolism in obese youth.
Department of Pediatrics, Yale University, New Haven, Connecticut, USA. melissa.m.shaw@yale.edu
Melissa
M
Shaw
Mary
M
Savoye
Anna
A
Cali
James
J
Dziura
William V
WV
Tamborlane
Sonia
S
Caprio
D000273:Adipose Tissue / Q000033:anatomy & histology; D000293:Adolescent; D015992:Body Mass Index; D002648:Child; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D008019:Life Style; D008297:Male; D009765:Obesity / Q000534:rehabilitation*; D015431:Weight Loss
D007328:Insulin