The 223A>G polymorphism of the leptin receptor gene and lipid-lowering efficacy of simvastatin in Chinese patients with coronary heart disease.
OBJECTIVE
To investigate whether leptin receptor (LEPR) 223A>G polymorphism influences serum lipid levels and whether this polymorphism affects the effectiveness of simvastatin in Chinese patients with coronary heart disease (CHD).


METHODS
A total of 312 patients with CHD were treated with simvastatin 20 mg/day. Fasting serum lipids were determined before and after 12 weeks of treatment.


RESULTS
Patients with AA genotype had significantly higher total cholesterol (TC) levels and lower high-density lipoprotein cholesterol (HDL-C) levels than those with GG genotype (P < 0.05) before simvastatin treatment. In addition, the ability of simvastatin to increase HDL-C levels was significantly lower in patients with AA genotype than those with GG genotype (P < 0.05).


CONCLUSIONS
The 223A>G polymorphism of LEPR significantly modulates the HDL-C response to simvastatin in Chinese patients with CHD.
Department of Cardiac Care Unit, First Clinical Hospital of Harbin Medical University, 23 Post Rd., Nangang Region, Harbin, 150001, China.
Yan-Ming
YM
Sun
Lan-Feng
LF
Wang
Jia
J
Li
Zhu-Qin
ZQ
Li
Wei
W
Pan
D000368:Aged; D000483:Alleles; D000808:Angiotensinogen / Q000235:genetics*; D044466:Asian People; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005838:Genotype; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D008055:Lipids / Q000037:antagonists & inhibitors* / Q000097:blood / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D054411:Receptors, Leptin / Q000235:genetics*; D019821:Simvastatin / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008055:Lipids; D054411:Receptors, Leptin; D000808:Angiotensinogen; D019821:Simvastatin