Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review.
Growing evidence indicates that insulin resistance and oxidative stress are involved in the pathogenesis of essential hypertension. In insulin-resistant states, like obesity and type 2 diabetes, altered glucose metabolism may lead to increased formation of methylglyoxal and other ketoaldehydes. Animal studies have shown that increased levels of endogenous aldehydes may lead to hypertension and oxidative stress. In animal models, the administration of vitamin C, vitamin B6 or alpha-lipoic acid reduced tissue levels of aldehydes, prevented oxidative stress, and lowered blood pressure. The purpose of this review article is to critically evaluate the available evidence for the role of dietary supplements in hypertension treatment.
1st Propedeutic Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece. axatzito@med.auth.gr
Apostolos
A
Hatzitolios
Fotios
F
Iliadis
Niki
N
Katsiki
Maria
M
Baltatzi
D000447:Aldehydes / Q000378:metabolism*; D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage; D019587:Dietary Supplements; D019317:Evidence-Based Medicine; D018149:Glucose Intolerance / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000178:diet therapy* / Q000209:etiology / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology; D008063:Thioctic Acid / Q000008:administration & dosage; D025101:Vitamin B 6 / Q000008:administration & dosage
D000447:Aldehydes; D008063:Thioctic Acid; D025101:Vitamin B 6; D001205:Ascorbic Acid