Intercellular adhesion molecule-1 K469E polymorphism in Korean patients with spontaneous preterm delivery.
OBJECTIVE
To investigate the association between intercellular adhesion molecule-1 (ICAM-1) gene K469E polymorphism and spontaneous preterm delivery in a Korean population.


METHODS
Genomic DNA was extracted from whole blood from 55 women experiencing preterm labor and 153 multiparous women (control group) with a history of at least 2 term deliveries. DNA samples were analyzed by polymerase chain reaction-restriction fragment length polymorphism.


RESULTS
The spontaneous preterm delivery (SPD) group carried the 469E allele significantly more frequently than those in the control group (odds ratio [OR], 1.62; 95% CI, 1.04-2.53). The EE genotype was significantly associated with increased risk of SPD (OR, 2.84; 95% CI, 1.17-6.89; P = 0.02). Allelic frequencies in women with abnormal C-reactive protein levels (K = 0.48; E = 0.52) were significantly different from frequencies in the controls (K = 0.68; E = 0.32) (P = 0.006).


CONCLUSIONS
ICAM-1 gene K469E polymorphism may be a candidate region and useful predictor of susceptibility to SPD in the Korean population.
Kwon
Han-Sung
HS
Department of Obstetrics and Gynecology, Konkuk University College of Medicine, Korea.
Sohn
In-Sook
IS
Lee
Ji-Young
JY
Lee
Sun-Joo
SJ
Kim
Soo-Nyung
SN
Kim
Bok-Ja
BJ
D000328:Adult; D002097:C-Reactive Protein; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D007723:Korea; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011247:Pregnancy; D047928:Premature Birth / Q000235:genetics*
D018799:Intercellular Adhesion Molecule-1; D002097:C-Reactive Protein