Detecting simulated patterns of lung cancer biomarkers by random network of single-walled carbon nanotubes coated with nonpolymeric organic materials.
An array of chemiresistive random network of single-walled carbon nanotubes coated with nonpolymeric organic materials shows a high potential for diagnosis of lung cancer via breath samples. The sensors array shows excellent discrimination between the volatile organic compounds (VOCs) found in the breath of patients with lung cancer, relative to healthy controls, especially if the sensors array is preceded with either water extractor and/or preconcentrator of VOCs. The pattern compositions of the healthy and cancerous states were determined by gas-chromatography linked with mass-spectroscopy (GC-MS) analysis of real exhaled breath.
The Department of Chemical Engineering and Russell Barrie Nanotechnology Institute, Technion-Israel Institute of Technology, Haifa 32000, Israel.
Gang
G
Peng
Elena
E
Trock
Hossam
H
Haick
D014408:Biomarkers, Tumor / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism*; D003198:Computer Simulation; D008401:Gas Chromatography-Mass Spectrometry; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D050997:Nanomedicine / Q000295:instrumentation / Q000379:methods*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D009930:Organic Chemicals / Q000737:chemistry; D011108:Polymers / Q000737:chemistry
D014408:Biomarkers, Tumor; D037742:Nanotubes, Carbon; D009930:Organic Chemicals; D011108:Polymers