Clastic cells: mineralized tissue resorption in health and disease.
Clastic cells are responsible for mineralized tissue resorption. Bone resorbing cells are called osteoclasts; however, they are able to resorb mineralized dental tissues or calcified cartilage and then they are called odontoclasts and chondroclasts, respectively. They derive from mononuclear precursors of the monocyte-macrophage lineage from hemopoietic tissue, reach target mineralized tissues and degrade them under many different physiologic or pathologic stimuli. Clastic cells play a key role in calcium homeostasis, and participate in skeletal growth, tooth movement, and other physiological and pathological events. They interact tightly with forming cells in bone and dental hard tissues; their unbalance may result in disturbed resorptive activity thus, causing local or systemic diseases.
Laboratory of Mineralized Tissue Biology, Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, 05508-900 São Paulo, SP, Brazil. vearana@usp.br
Victor E
VE
Arana-Chavez
Vivian
V
Bradaschia-Correa
D000818:Animals; D001847:Bone Diseases / Q000473:pathology / Q000503:physiopathology*; D001861:Bone Regeneration; D001862:Bone Resorption; D002113:Calcification, Physiologic / Q000502:physiology*; D002118:Calcium / Q000378:metabolism*; D002454:Cell Differentiation; D019070:Cell Lineage; D006801:Humans; D008264:Macrophages / Q000166:cytology; D009805:Odontogenesis / Q000502:physiology*; D010010:Osteoclasts / Q000473:pathology / Q000502:physiology*; D010012:Osteogenesis / Q000502:physiology; D014070:Tooth / Q000166:cytology / Q000254:growth & development
D002118:Calcium