Outcome of radiotherapy in T1 glottic carcinoma: a population-based study.
We evaluated the radiation outcome and prognostic factors in a population-based study of early (T1N0M0) glottic carcinoma. Survival parameters and prognostic factors were evaluated by uni- and multivariate analysis in 316 consecutive irradiated patients with T1 glottic carcinoma in the Comprehensive Cancer Center West region of the western Netherlands. Median follow-up was 70 months (range 1-190 months). Five and ten-year local control was 86 and 84%. Disease specific survival was 97% at 5 and 10 years. In multivariate analysis, pre-existent laryngeal hypertrophic laryngitis was the only predictive factor for local control (relative risk = 3.0, P = 0.02). Comorbidity was prognostic for overall survival. No factor was predictive for disease specific survival. Pre-existent laryngeal hypertrophic laryngitis is a new risk factor associated with reduced local control in T1 glottic carcinoma treated with radiotherapy.
Department of ENT, Head and Neck Surgery, J6, Leiden University Medical Center, Albinusdreef 2, Postbus 9600, 2300 RC, Leiden, The Netherlands. evsjogren@lumc.nl
Elisabeth Victoria
EV
Sjögren
Ruud G J
RG
Wiggenraad
Saskia
S
Le Cessie
Simone
S
Snijder
Jaqueline
J
Pomp
Robert Jan
RJ
Baatenburg de Jong
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000453:epidemiology / Q000473:pathology* / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D005931:Glottis / Q000473:pathology* / Q000528:radiation effects*; D006801:Humans; D006984:Hypertrophy / Q000473:pathology; D007822:Laryngeal Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000532:radiotherapy*; D007827:Laryngitis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011159:Population Surveillance / Q000379:methods; D011237:Predictive Value of Tests; D011300:Preoperative Care; D015996:Survival Rate