Accurate coarse-grained modeling of red blood cells.
We develop a systematic coarse-graining procedure for modeling red blood cells (RBCs) using arguments based on mean-field theory. The three-dimensional RBC membrane model takes into account the bending energy, in-plane shear energy, and constraints of fixed surface area and fixed enclosed volume. The coarse-graining procedure is general, it can be used for arbitrary level of coarse-graining and does not employ any fitting parameters. The sensitivity of the coarse-grained model is investigated and its behavior is validated against available experimental data and in dissipative particle dynamics (DPD) simulations of RBCs in capillary and shear flows.
Pivkin
Igor V
IV
Division of Applied Mathematics, Brown University, Providence, Rhode Island 02912, USA. piv@damn.brown.edu
Karniadakis
George Em
GE
D000465:Algorithms; D001783:Blood Flow Velocity / Q000502:physiology*; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism*; D003198:Computer Simulation; D004912:Erythrocytes / Q000737:chemistry / Q000378:metabolism*; D044085:Microfluidics / Q000379:methods*; D008954:Models, Biological; D010316:Particle Size; D033081:Shear Strength; D013314:Stress, Mechanical; D013499:Surface Properties; D013816:Thermodynamics