Bacterial homologue of human blood group A transferase.
A bacterial version of human blood group A transferase was identified and found to be able to accept five naturally existing H-antigen core structures as good substrates, demonstrating its versatility for synthesis of blood group A antigens. Furthermore, this enzyme was applied in the engineering of bacterial cell surface polysaccharides by remodeling blood group B mimicry into blood group A mimicry.
Department of Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA.
Wen
W
Yi
Jie
J
Shen
Guangyan
G
Zhou
Jianjun
J
Li
Peng George
PG
Wang
D000017:ABO Blood-Group System / Q000097:blood / Q000378:metabolism; D001426:Bacterial Proteins / Q000737:chemistry* / Q000378:metabolism*; D002240:Carbohydrate Sequence; D004926:Escherichia coli / Q000378:metabolism; D005646:Fucosyl Galactose alpha-N-Acetylgalactosaminyltransferase / Q000097:blood / Q000737:chemistry* / Q000378:metabolism*; D045502:Helicobacter mustelae / Q000201:enzymology*; D006801:Humans; D008070:Lipopolysaccharides / Q000737:chemistry / Q000378:metabolism; D008969:Molecular Sequence Data; D013379:Substrate Specificity
D000017:ABO Blood-Group System; D001426:Bacterial Proteins; D008070:Lipopolysaccharides; D005646:Fucosyl Galactose alpha-N-Acetylgalactosaminyltransferase