Ovarian large cell neuroendocrine carcinoma.
Ovarian large cell neuroendocrine carcinoma (LCNC) is a rare disease that is commonly associated with a surface epithelial and germ cell neoplasm component. A 46-year-old woman presented with a pelvic mass measuring 15 cm in diameter. She underwent an exploratory laparotomy with resection of the pelvic mass. Diffuse and nodular intra-abdominal disseminations were observed. Stage III LCNC associated with squamous differentiation alone of the right ovary was diagnosed. The patient died of progressive disease 4 months postoperatively despite paclitaxel and carboplatin therapy. Ovarian LCNC associated with squamous differentiation component alone has never been reported, but its prognosis may be poor.
Tsuji
Takahiro
T
Department of Reproductive Pathophysiology and Obstet-Gynecology, Kagoshima University, Sakuragaoka, Kagoshima, Japan. tsujita@m3.kufm.kagoshima-u.ac.jp
Togami
Shinichi
S
Shintomo
Nao
N
Fukamachi
Nobuyuki
N
Douchi
Tsutomu
T
Taguchi
Shuuhei
S
D018278:Carcinoma, Neuroendocrine / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology*; D010053:Ovary / Q000473:pathology*