Drug-elicited systemic allergic (contact) dermatitis--update and possible pathomechanisms.
An allergic dermatitis reaction may develop after systemic exposure to a hapten that reaches the skin through haematogenous transport. This condition can be observed with and without previous cutaneous sensitization to the hapten but has traditionally been described following topical exposure. A heterogeneous clinical picture, in combination with limited insight to its pathomechanisms, makes such systemic reactions an area in need of further study. This article summarizes knowledge about systemic dermatitis elicited by drugs, with a special emphasis on possible pathomechanisms. A list of putative pathomechanisms is offered for future research. Literature was examined using PubMed-MEDLINE, EMBASE, Biosis, and Science Citation Index. Based on the literature, it is likely that humoral type 3, delayed-type hypersensitivity, and drug-driven (i.e. p-i concept) reactions are involved. As commonly used terms may be misleading because skin contact is not a prerequisite, we suggest that the term 'systemic allergic dermatitis' should be used in the future.
Thyssen
Jacob Pontoppidan
JP
Department of Dermatology, National Allergy Research Centre, Gentofte University Hospital, Ledreborg Allé 40, 1. 2820 Gentofte, Denmark. jacpth01@geh.regionh.dk
Maibach
Howard Ira
HI
D000485:Allergens / Q000009:adverse effects; D003692:Delayed-Action Preparations / Q000008:administration & dosage; D017449:Dermatitis, Allergic Contact / Q000453:epidemiology* / Q000209:etiology*; D004337:Drug Carriers / Q000008:administration & dosage; D003875:Drug Eruptions / Q000453:epidemiology / Q000209:etiology; D006241:Haptens / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced / Q000453:epidemiology
D000485:Allergens; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006241:Haptens