[Expression and clinical significance of cyclooxygenase-2 in nasal and paranasal sinus carcinoma].
OBJECTIVE
To investigate the relationship between the expression of cyclooxygenase-2 (COX-2) and the carcinogenesis and invasive behavior of nasal and paranasal sinus carcinoma (NPSC).


METHODS
The expression of COX-2 were detected in 69 case NPSC tissues, paracancerous atypical hyperplasia tissue and normal tissue by using immunohistochemical techniques of SP method.


RESULTS
The positive rate of COX-2 in NPSC tissues and atypical hyperplasia tissue and normal tissue was 65.22% and 42.31% and 3.33%, respectively. The positive rate of COX-2 in NPSC tissues was significantly higher than that in normal tissue (P < 0.01), and increased apparently with the lesion progressing from normal to atypical hyperplasia tissue to NPSC tissues, and also correlated with the increasing of tumor (P < 0.05).


CONCLUSIONS
COX-2 may play an important role in the carcinogenesis and invasion of NPSC.
Department of Otolaryngology, the Affiliated Hospital of Guangdong Medical College, Zhanjiang, 524001, China. cuidewei@163.com
Dewei
D
Cui
Fuquan
F
Xie
Xiangbao
X
Zhang
D000368:Aged; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity / Q000473:pathology; D009367:Neoplasm Staging; D009669:Nose Neoplasms / Q000378:metabolism* / Q000473:pathology; D010255:Paranasal Sinus Neoplasms / Q000378:metabolism* / Q000473:pathology
D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human