Towards a cure for food allergy.
Over the past two decades, food allergies have become both more prevalent and long lasting. This burgeoning problem has not been met with any therapeutic options to date, and patients must attempt to avoid known allergenic foods and treat any allergic reactions with 'as-needed' medications. There are a number of promising emerging therapeutic modalities for food allergy, including allergen-specific and allergen non-specific immunotherapeutic approaches. Although the allergen-specific approaches have some distinct differences, they all attempt to induce tolerance by exposing the patient to an allergen via the mucosal route (oral tolerance induction). Allergen non-specific approaches include biologics to suppress free total IgE levels (e.g. anti-IgE antibody) or to induce more general immune suppression (Chinese herbal medication).
Skripak
Justin M
JM
Mount Sinai School of Medicine, New York, NY, United States.
Sampson
Hugh A
HA
D000284:Administration, Oral; D000286:Administration, Sublingual; D000485:Allergens / Q000008:administration & dosage*; D003888:Desensitization, Immunologic / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage; D005512:Food Hypersensitivity / Q000517:prevention & control / Q000628:therapy*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D011994:Recombinant Proteins / Q000008:administration & dosage
D000485:Allergens; D004365:Drugs, Chinese Herbal; D011994:Recombinant Proteins; D007073:Immunoglobulin E