BOLD-MRI cerebrovascular reactivity findings in cocaine-induced cerebral vasculitis.
BACKGROUND
An 18-year-old woman presented to a regional stroke center with dysphasia and right hemiparesis 2 days after consuming alcohol and inhaling cannabis and -- for the first time -- cocaine.


METHODS
Physical examination, blood tests for inflammatory markers, vasculitis and toxicology screen, echocardiography, electrocardiography, CT scanning, brain MRI, magnetic resonance angiography, magnetic resonance vessel wall imaging, catheter angiography, and correlation of blood oxygen level-dependent (BOLD)-MRI signal intensity with changes in end-tidal partial pressure of carbon dioxide.


METHODS
Cocaine-induced cerebral vasculitis.


RESULTS
No specific therapy was initiated. The patient's vital signs and neurological status were monitored during her admission. Follow-up medical imaging was performed after the patient's discharge from hospital.
Department of Physiology at the University of Toronto, Toronto, ON, Canada.
Jay S
JS
Han
Daniel M
DM
Mandell
Julien
J
Poublanc
Alexandra
A
Mardimae
Marat
M
Slessarev
Cheryl
C
Jaigobin
Joseph A
JA
Fisher
David J
DJ
Mikulis
D000293:Adolescent; D000428:Alcohol Drinking / Q000009:adverse effects; D001921:Brain / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology; D001931:Brain Mapping; D002492:Central Nervous System Depressants / Q000009:adverse effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003042:Cocaine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D008385:Marijuana Smoking / Q000009:adverse effects; D020293:Vasculitis, Central Nervous System / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D014662:Vasoconstrictor Agents / Q000009:adverse effects*
D002492:Central Nervous System Depressants; D014662:Vasoconstrictor Agents; D003042:Cocaine