Liquid nitrogen cryotherapy of superior limbic keratoconjunctivitis.
OBJECTIVE
To evaluate the effects of liquid nitrogen cryotherapy on superior limbic keratoconjunctivitis (SLK).


METHODS
Interventional case series.


METHODS
In this clinical practice case series, the effects of liquid nitrogen cryotherapy on SLK were observed. Liquid nitrogen cryotherapy was performed using a Brymill E tip spray (0.013-inch aperture) with a double freeze-thaw technique. All subjects were outpatients who had local anesthesia with a single drop of topical proparacaine. The main outcome measure was the resolution of the disease process after treatment.


RESULTS
Four female patients (average age, 64 +/- 13 years) and seven eyes with SLK were treated with liquid nitrogen cryotherapy. Resolution of signs and symptoms occurred within two weeks. Disease recurred in two patients and three of seven eyes, although repeat cryotherapy eradicated SLK in all cases. The repeat cryotherapy was performed at three months postoperatively. There were no adverse ocular events.


CONCLUSIONS
Liquid nitrogen cryotherapy appears to be an effective alternative treatment for SLK as all subjects studied achieved long-term cures. Repeat cryotherapy may be necessary in some instances and may be performed three months after the first treatment.
Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA. eyedrug@ohsu.edu
Frederick W
FW
Fraunfelder
D000368:Aged; D000772:Anesthesia, Local; D000779:Anesthetics, Local / Q000008:administration & dosage; D003452:Cryosurgery / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007637:Keratoconjunctivitis / Q000601:surgery*; D016850:Limbus Corneae / Q000601:surgery*; D008875:Middle Aged; D009584:Nitrogen; D011430:Propoxycaine / Q000008:administration & dosage; D012008:Recurrence; D016896:Treatment Outcome
D000779:Anesthetics, Local; C005717:proxymetacaine; D011430:Propoxycaine; D009584:Nitrogen