[Juvenile scleroderma].
Juvenile scleroderma is a rare childhood condition characterized by fibrosis of the skin and internal organs. Clinical manifestations of childhood scleroderma are different from adult disease and early recognition, correct classification and treatment can improve long-term outcome. This review explores the most recent actualizations on clinical manifestations, classification criteria, treatment options and prognosis of juvenile scleroderma. There are two main forms of the disease: localized scleroderma and systemic sclerosis. Localized scleroderma is the most common form in children and mostly restricted to the skin. Juvenile diffuse systemic sclerosis is related to visceral involvement and cardiac disease which is the main cause of death in these patients. The outcome of juvenile systemic sclerosis is better compared with the adult form. Treatment remains a medical challenge and the EULAR task force proposed an approach to juvenile scleroderma treatment based on expert's opinion and guidelines used for the treatment of adults. Larger studies on childhood scleroderma are warranted.
Serviço de Reumatologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil.
Patrícia Andrade
PA
de Mâcedo
Samuel Katsuyuki
SK
Shinjo
Cláudia
C
Goldenstein-Schainberg
D002648:Child; D006801:Humans; D012594:Scleroderma, Localized / Q000175:diagnosis / Q000628:therapy; D012595:Scleroderma, Systemic / Q000175:diagnosis / Q000628:therapy
Esclerodermia juvenil.