Low pre-infection levels and loss of central memory CD4+ T cells may predict rapid progression in SIV-infected pigtail macaques.
CD4+ T lymphocyte subsets are targeted to different degrees by SIV infection. We studied central memory, effector memory, naïve, and regulatory T cell levels longitudinally in 11 SIV(mac251)-infected pigtail macaques. Depletion of CD28+CD95+ central memory CD4+ T cells, but not other populations, correlated with both SIV viral load and disease progression. A low pre-infection level of central memory CD4+ T cells was also predictive of rapid disease progression. If confirmed in larger studies, our results suggest stratifying macaques for baseline central memory CD4+ T cells would be useful in defining both the pathogenesis of SIV disease and SIV vaccine efficacy.
Mason
Rosemarie D
RD
Department of Microbiology and Immunology, University of Melbourne, 3010 Australia.
Rose
Robert De
RD
Seddiki
Nabila
N
Kelleher
Anthony D
AD
Kent
Stephen J
SJ
D000818:Animals; D015704:CD4 Antigens / Q000276:immunology; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018450:Disease Progression; D007156:Immunologic Memory; D008254:Macaca nemestrina / Q000276:immunology* / Q000821:virology*; D010641:Phenotype; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000502:physiology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014766:Viremia / Q000276:immunology
D015704:CD4 Antigens