Mechanisms of twinning: X. The male factor.
OBJECTIVE
To evaluate the possibility of male-line inheritance of dizygotic twinning potential.


METHODS
Women with multiple births who had previously volunteered to participate in studies in this series were asked about the frequency of males genetically related to the index mother's husband who had also fathered multiples. Only spontaneous gestations were considered.


RESULTS
If male involvement in twin pregnancies were entirely random, <1% would have had male relatives who had also fathered multifetal gestations. However, 30% were found to have such relatives in the families evaluated here.


CONCLUSIONS
These results suggest that the capability to father multiples (twins or higher) spontaneously is, in many cases, an inherited trait along the male line--i.e., the male factor in twinning. Producing multiples requires not only women able to doubly ovulate but also men capable of supplying active sperm that could fertilize >1 egg in a given cycle.
Steinman
Gary
G
Department of Obstetrics and Gynecology, Long Island Jewish Medical Center, New Hyde Park, New York, USA. dav4601@aol.com
D015331:Cohort Studies; D005220:Fathers; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006306:Health Surveys; D006801:Humans; D020407:Internet; D008297:Male; D011247:Pregnancy; D012737:Sex Factors; D014429:Twins, Dizygotic / Q000235:genetics*