Session 2: Personalised nutrition. Transcriptomic signatures that have identified key features of metabolic syndrome.
The Human Genome Project and rapid advances in high-throughput molecular technologies are providing an unprecedented opportunity to advance the understanding of the common polygenic diet-related diseases, including obesity, the metabolic syndrome, type 2 diabetes mellitus, CVD and some cancers. In particular, transcriptomic approaches that allow multiple simultaneous gene-expression profiles facilitate the characterisation of metabolic perturbations that underlie diet-related pathologies. The present paper will focus on 'transcriptomic signatures' to characterise and understand the molecular mechanisms that accurately reflect 'metabolic health'.
Nutrigenomics Research Group, UCD School of Public Health & Population Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Republic of Ireland.
Melissa J
MJ
Morine
Cathal
C
O'Brien
Helen M
HM
Roche
D019295:Computational Biology; D004041:Dietary Fats / Q000008:administration & dosage; D006801:Humans; D024821:Metabolic Syndrome / Q000235:genetics* / Q000378:metabolism; D054647:Nutrigenomics / Q000379:methods*; D014158:Transcription, Genetic
D004041:Dietary Fats