Direct synthesis of chrysosplenol D.
An aldol condensation and an Algar-Flynn-Oyamada oxidative cyclization were key steps in the direct synthesis of chrysosplenol D, an efflux pump inhibitor that can potentiate the activity of commercially important antibiotics and antimalarials.
Kraus
George
G
Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA. gakraus@iastate.edu
Roy
Sudipta
S
D019306:Artemisia / Q000737:chemistry; D003500:Cyclization; D047309:Flavones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction
D047309:Flavones; C568008:chrysosplenol D