Hypertension and circulating mRNA for 11beta-hydroxysteroid dehydrogenase type II.
Circulating DNA and mRNA for 11beta-hydoxysteroid dehydrogenase (HSD) type II were measured in patients with hypertension and in healthy subjects. DNA and RNA levels in hypertensive patients and controls were quantified using real-time RT-PCR. Messenger RNA for 11beta-HSD type II was significantly lower in the hypertensive patients (median: 0.18) (P= 0.032) than in healthy subjects (median: 0.42). Plasma DNA was also significantly lower (P= 0.016) in hypertension. It is suggested that measurement of mRNA for 11beta-HSD type II in hypertension may identify subjects who may be salt-sensitive.
Department of Chemical Pathology, Guy's and St. Thomas' Hospital NHS Foundation Trust, London, United Kingdom.
S
S
Agalou
A N
AN
Butt
Phil
P
Chowienczyk
R
R
Swaminathan
D043209:11-beta-Hydroxysteroid Dehydrogenase Type 2 / Q000097:blood / Q000235:genetics*; D000328:Adult; D044383:Black People / Q000235:genetics; D004247:DNA / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000201:enzymology / Q000235:genetics; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000097:blood*; D044465:White People / Q000235:genetics
D012333:RNA, Messenger; D004247:DNA; D043209:11-beta-Hydroxysteroid Dehydrogenase Type 2