Susceptibility variants for male-pattern baldness on chromosome 20p11.
We carried out a genome-wide association study in 296 individuals with male-pattern baldness (androgenetic alopecia) and 347 controls. We then investigated the 30 best SNPs in an independent replication sample and found highly significant association for five SNPs on chromosome 20p11 (rs2180439 combined P = 2.7 x 10(-15)). No interaction was detected with the X-chromosomal androgen receptor locus, suggesting that the 20p11 locus has a role in a yet-to-be-identified androgen-independent pathway.
Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany. axel.hillmer@uni-bonn.de
Axel M
AM
Hillmer
Felix F
FF
Brockschmidt
Sandra
S
Hanneken
Sibylle
S
Eigelshoven
Michael
M
Steffens
Antonia
A
Flaquer
Stefan
S
Herms
Tim
T
Becker
Anne-Katrin
AK
Kortüm
Dale R
DR
Nyholt
Zhen Zhen
ZZ
Zhao
Grant W
GW
Montgomery
Nicholas G
NG
Martin
Thomas W
TW
Mühleisen
Margrieta A
MA
Alblas
Susanne
S
Moebus
Karl-Heinz
KH
Jöckel
Martina
M
Bröcker-Preuss
Raimund
R
Erbel
Roman
R
Reinartz
Regina C
RC
Betz
Sven
S
Cichon
Peter
P
Propping
Max P
MP
Baur
Thomas F
TF
Wienker
Roland
R
Kruse
Markus M
MM
Nöthen
D000328:Adult; D000505:Alopecia / Q000235:genetics*; D002890:Chromosomes, Human, Pair 20 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D015894:Genome, Human / Q000235:genetics; D005858:Germany; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics