A diazirine-based nucleoside analogue for efficient DNA interstrand photocross-linking.
A diazirine-based nucleoside analogue (DBN) efficiently forms DNA interstand cross-linking under near-UV irradiation. This new base analogue may find broad applications in biotechnology and phototherapy.
Department of Chemistry, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA.
Zhihai
Z
Qiu
Lianghua
L
Lu
Xing
X
Jian
Chuan
C
He
D004247:DNA / Q000737:chemistry* / Q000528:radiation effects*; D003978:Diazomethane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D008958:Models, Molecular; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry*; D055668:Photochemical Processes; D013816:Thermodynamics; D014466:Ultraviolet Rays
D009705:Nucleosides; D003978:Diazomethane; D004247:DNA