Structural identifiability of a model for the acetic acid fermentation process.
Modelling has proved an essential tool for addressing research into biotechnological processes, particularly with a view to their optimization and control. Parameter estimation via optimization approaches is among the major steps in the development of biotechnology models. In fact, one of the first tasks in the development process is to determine whether the parameters concerned can be unambiguously determined and provide meaningful physical conclusions as a result. The analysis process is known as 'identifiability' and presents two different aspects: structural or theoretical identifiability and practical identifiability. While structural identifiability is concerned with model structure alone, practical identifiability takes into account both the quantity and quality of experimental data. In this work, we discuss the theoretical identifiability of a new model for the acetic acid fermentation process and review existing methods for this purpose.
Jiménez-Hornero
Jorge E
JE
Computing and Numerical Analysis Department, University of Córdoba, P.O. Box 14071, Córdoba, Spain. jjimenez@uco.es
Santos-Dueñas
Inés M
IM
Garci A-Garci A
Isidoro
I
D019342:Acetic Acid / Q000378:metabolism*; D001709:Biotechnology / Q000379:methods*; D005285:Fermentation; D008954:Models, Biological; D009716:Numerical Analysis, Computer-Assisted
D019342:Acetic Acid