[Differential diagnosis of giant cell-rich lesions of bone].
The diagnosis of giant cell-rich lesions of bone is often problematic even for the experienced pathologist. The diagnostic key lies in multinucleated osteoclast-like giant cells and a mononuclear stroma. From the histological picture alone it is often difficult to distinguish between individual entities such as conventional giant-cell tumor of bone, non-ossifying fibroma, giant-cell tumor in hyperparathyroidism or an aneurysmal bone cyst. Furthermore, these lesions can be confused with malignant bone tumors such as giant cell-rich osteosarcoma. X-ray is important for a correct diagnosis since some of these tumors show a typical anatomic location, while age of the patient is also an important factor. In most cases diagnosis is made on the basis of intraoperative frozen-section, but even in this setting, due to the poor quality of the material, it is very difficult to make a correct diagnosis of giant cell-rich lesions without X-ray and clinical data.
Klinisches Institut für Pathologie, Universitätsklinik Wien, Währinger Gürtel 18-20, 1090 Wien, Osterreich. susanna.lang@meduniwien.ac.at
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D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D001842:Bone and Bones / Q000473:pathology; D002648:Child; D003238:Connective Tissue / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D005629:Frozen Sections; D018212:Giant Cell Tumor of Bone / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D010010:Osteoclasts / Q000473:pathology; D055815:Young Adult
Differenzialdiagnose riesenzellreicher Knochenläsionen.