99mTc-labeled dextran for mammary lymphoscintigraphy in dogs.
Lymphoscintigraphy is the technique of choice for sentinel lymph node detection in women with early breast cancer, but there is limited information evaluating the value of this technique in animals. We investigated mammary lymphatic drainage in 25 young female mongrel dogs by intramammary injection of 18.5 MBq of 99mTc-dextran (70,000 Da). Lymph node anatomical referencing was obtained using an external marker, bone scintigraphy, or scintiscanning the body contour. Cranial and caudal thoracic mammary glands drained into the cranial sternal lymph node and axillary lymph center. The cranial thoracic mammary gland also drained into the superficial cervical lymph node in two of five animals. The cranial abdominal gland was drained by the axillary lymph center. The caudal abdominal mammary gland was drained by the superficial inguinal lymph node in all animals and simultaneously by medial iliac lymph nodes in four of five animals. In one dog, this mammary gland was also drained by the mediastinal and the superficial cervical lymph nodes. The inguinal mammary gland was drained by superficial inguinal lymph nodes and simultaneously via the medial iliac lymph node in one animal. Lymphatic communications between lymph nodes were identified in 11 of 25 (44%) animals. 99mTc-dextran mammary lymphoscintigraphy was easy and rapid to perform and may provide valuable information for further studies.
Pereira
Camila Trevisan
CT
Department of Surgery, Veterinary Medicine School, University of São Paulo, São Paulo, SP, Brazil. camilatp@usp.br
Luiz Navarro Marques
Fabio
F
Williams
Jamie
J
Wlademir De Martin
Benedicto
B
Primo Bombonato
Pedro
P
D000818:Animals; D004283:Dog Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000503:physiopathology; D004285:Dogs / Q000033:anatomy & histology / Q000502:physiology; D005260:Female; D008198:Lymph Nodes / Q000033:anatomy & histology / Q000000981:diagnostic imaging* / Q000502:physiology; D008208:Lymphatic System / Q000033:anatomy & histology / Q000502:physiology; D042601:Lymphatic Vessels / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000502:physiology; D061305:Lymphoscintigraphy; D008321:Mammary Glands, Animal / Q000033:anatomy & histology / Q000000981:diagnostic imaging* / Q000502:physiology; D015674:Mammary Neoplasms, Animal / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000503:physiopathology; D011877:Radionuclide Imaging / Q000379:methods / Q000662:veterinary*; D019275:Radiopharmaceuticals; D017556:Technetium Compounds
D019275:Radiopharmaceuticals; D017556:Technetium Compounds