Modulation of CTCF insulator function by transcription of a noncoding RNA.
CTCF plays diverse roles in the regulation of eukaryotic genes. A new study by Lefevre et al. in a recent issue of Molecular Cell reveals a novel mechanism in which noncoding RNA transcription and nucleosome repositioning evicts CTCF from a regulatory element to facilitate induction of a nearby gene.
Ong
Chin-Tong
CT
Department of Biology, Emory University, 1510 Clifton Rd NE, Atlanta, GA 30322, USA.
Corces
Victor G
VG
D000076246:CCCTC-Binding Factor; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D038101:Insulator Elements / Q000235:genetics*; D008954:Models, Biological; D009707:Nucleosomes; D022661:RNA, Untranslated / Q000235:genetics* / Q000502:physiology; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D014158:Transcription, Genetic
D000076246:CCCTC-Binding Factor; C000619697:CTCF protein, human; D004268:DNA-Binding Proteins; D009707:Nucleosomes; D022661:RNA, Untranslated; D012097:Repressor Proteins