Mechanism of Ca(2+)-dependent desensitization in TRP channels.
The 30+ members of the family of TRP channels are diverse in their physiological roles, yet the mechanisms that regulate their gating may be conserved. In particular, all TRP channels show an activity-dependent inhibition which is mediated by Ca(2+). The mechanism by which Ca(2+) inhibits TRP channels is currently a matter of intense debate, with Ca(2+)-regulated kinases, phosphatases, phospholipases and calmodulin all proposed to be involved. In this review, we will discuss different mechanisms for Ca(2+)-dependent desensitization in TRP channels. We will conclude with a model that focuses on Ca(2+)-dependent activation of phospholipase C and Ca(2+) binding to calmodulin and propose that the phospholipase C and calmodulin pathways are structurally and functionally coupled.
Gordon-Shaag
Ariela
A
Department of Optometry and Vision Science, Hadassah College, Jerusalem, Israel.
Zagotta
William N
WN
Gordon
Sharona E
SE
D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D002147:Calmodulin / Q000378:metabolism; D006801:Humans; D015640:Ion Channel Gating / Q000187:drug effects; D050052:TRPC Cation Channels / Q000037:antagonists & inhibitors* / Q000502:physiology; D010738:Type C Phospholipases / Q000378:metabolism
D002147:Calmodulin; D050052:TRPC Cation Channels; D010738:Type C Phospholipases; D002118:Calcium