Alterations in Event Related Potentials (ERP) associated with tinnitus distress and attention.
Tinnitus related distress corresponds to different degrees of attention paid to the tinnitus. Shifting attention to a signal other than the tinnitus is therefore particularly difficult for patients with high tinnitus related distress. As attention effects on Event Related Potentials (ERP) have been shown this should be reflected in ERP measurements (N100, phase locking). In order to prove this hypothesis single sweep ERP recordings were obtained in 41 tinnitus patients as well as 10 control subjects during a period of time when attention was shifted to a tone (attended) and during a second phase (unattended) when they did not focus attention to the tone. Whereas tinnitus patients with low distress showed a significant reduction in both N100 amplitude and phase locking when comparing the attended and unattended measurement condition a group of patients with high tinnitus related distress did not show such ERP alterations. Using single sweep ERP measurements the results of our study show, that attention in high tinnitus related distress patients is captured by their tinnitus significantly more than in low distress patients. Furthermore our results provide the basis for future neurofeedback based tinnitus therapies aiming at maximizing the ability to shift attention away from the tinnitus.
ENT-Department, University of Saarland, HNO-Klinik Kirrbergerstr, Homburg/Saar 66421, Germany. hnowdel@uniklinik-saarland.de
Wolfgang
W
Delb
Daniel J
DJ
Strauss
Yin Fen
YF
Low
Harald
H
Seidler
A
A
Rheinschmitt
T
T
Wobrock
Roberto
R
D'Amelio
D000161:Acoustic Stimulation; D000328:Adult; D000368:Aged; D001143:Arousal / Q000502:physiology*; D001288:Attention / Q000502:physiology*; D004292:Dominance, Cerebral / Q000502:physiology; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011930:Reaction Time / Q000502:physiology; D012815:Signal Processing, Computer-Assisted; D011795:Surveys and Questionnaires; D014012:Tinnitus / Q000503:physiopathology*; D055815:Young Adult