Synthesis of marine natural products with antimalarial activity.
The role played by synthetic organic chemistry of marine metabolites as potential leads for drug discovery of antimalarial agents is discussed. Syntheses of the most promising molecules are summarized, with emphasis on structure-activity relationship (SAR) studies and their mechanism of action.
Mancini
Ines
I
Laboratorio di Chimica Bioorganica, Dipartimento di Fisica, Università di Trento, Povo Trento, Italy. mancini@science.unitn.it
Guella
Graziano
G
Defant
Andrea
A
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D006801:Humans; D007155:Immunologic Factors / Q000737:chemistry; D007659:Ketones; D008956:Models, Chemical; D009570:Nitriles / Q000737:chemistry; D010545:Peroxides / Q000378:metabolism; D013329:Structure-Activity Relationship
D000962:Antimalarials; D000981:Antiprotozoal Agents; D001688:Biological Products; D007155:Immunologic Factors; D007659:Ketones; D009570:Nitriles; D010545:Peroxides