Cytokines that regulate autoimmunity.
Recent advances have revealed new insights in cytokine regulation of inflammatory responses. TGFbeta acting together with pro-inflammatory cytokines such as IL-6 promotes lineage commitment of RORgamma-dependent Th17 cells. IL-23--a member of the IL-12 family--activates the effector function of Th17 cells to promote skin, lung, and mucosal immunity. However, when dysregulated, these cells are important players in autoimmune inflammation. Unexpectedly, IL-27--another IL-12 family member--plays an opposing role by inducing IL-10 production as well as downregulating both Th17 and Th1-mediated immune pathologies.
Discovery Research, Schering-Plough Biopharma (formerly DNAX Research Institute), 901 California Avenue, Palo Alto CA 94304, United States.
Caroline
C
Diveu
Mandy J
MJ
McGeachy
Daniel J
DJ
Cua
D000818:Animals; D015551:Autoimmunity / Q000276:immunology*; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D016753:Interleukin-10 / Q000276:immunology; D018664:Interleukin-12 / Q000276:immunology; D020381:Interleukin-17 / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D016207:Cytokines; D020381:Interleukin-17; D016753:Interleukin-10; D018664:Interleukin-12