[The influence of demographic and clinical parameters on arterial elasticity indices in families with hypertension and coronary artery disease].
The aim of this study was to assess associations between clinical factors and large (C1) and small (C2) artery elasticity indices. The study was performed in a group consisting of 162 persons: 81 men and 81 women (mean age--43.7 +/- 16.1 years), representing 45 families (88 parents--50 suffering from hypertension, 50 with ischaemic heart disease, 9 type 2 diabetic patients and 74 offsprings--5 with hypertension, 1 with ischaemic heart disease). Mean age in the group of parents was 56.4 +/- 8.3 years, in the group of children--28.7 +/- 8.3 years. Arterial elasticity was assessed using HDI Pulsewave TM CR-2000 machine. Subjects with hypertension had lower C1 than those with normotension (12.2 +/- 4.1 vs 15.0 +/- 3.7, p < 0.00002) and diabetic subjects exhibited lower C1 than non-diabetic controls (11.4 +/- 2.8 vs 14.3 +/- 4, p < 0.04). C2 value was significantly lower in subjects with hypertension (4.1 +/- 2.3 vs 6.7 +/- 2.9, p < 8 x 10(-2)) than in normotensives and patients with coronary artery disease had lower C2 than subjects without heart disease (4.2 +/- 2.1 vs 6.6 +/- 3.1, p < 6 x 10(-6)). C1 correlated inversely with systolic (Rs = -0.54, p < 8 x 10(-14)) and diastolic pressure (r = -0.33, p < 0.003), as well as C2. Filial C1 correlated positively with paternal C1 (Rs = 0.3, p < 0.04). Our data indicate that traditional cardiovascular risk factors correlate with marker of arterial elasticity. Correlation between C1 in fathers and sons suggests the familial predisposition in the group of men.
Sedkowska
Agnieszka
A
I Katedra i Oddział Kliniczny Kardiologii, Wydziału Lekarskiego w Zabrzu, Slaskiej Akademii Medycznej w Katowicach, 41-800 Zabrze, ul. Szpitalna 2. agasedko@poczta.onet.pl
Zukowska-Szczechowska
Ewa
E
D000328:Adult; D001158:Arteries / Q000503:physiopathology*; D015897:Comorbidity; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000235:genetics; D003925:Diabetic Angiopathies / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology*; D004548:Elasticity; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D017678:Sex Distribution; D012737:Sex Factors
Ocena wpływu czynników demograficznych i klinicznych na wskaźniki elastyczności naczyń tetniczych w rodzinach chorych na nadciśnienie tetnicze i chorobe niedokrwienna serca.