Male-pattern baldness susceptibility locus at 20p11.
We conducted a genome-wide association study for androgenic alopecia in 1,125 men and identified a newly associated locus at chromosome 20p11.22, confirmed in three independent cohorts (n = 1,650; OR = 1.60, P = 1.1 x 10(-14) for rs1160312). The one man in seven who harbors risk alleles at both 20p11.22 and AR (encoding the androgen receptor) has a sevenfold-increased odds of androgenic alopecia (OR = 7.12, P = 3.7 x 10(-15)).
Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
J Brent
JB
Richards
Xin
X
Yuan
Frank
F
Geller
Dawn
D
Waterworth
Veronique
V
Bataille
Daniel
D
Glass
Kijoung
K
Song
Gerard
G
Waeber
Peter
P
Vollenweider
Katja K H
KK
Aben
Lambertus A
LA
Kiemeney
Bragi
B
Walters
Nicole
N
Soranzo
Unnur
U
Thorsteinsdottir
Augustine
A
Kong
Thorunn
T
Rafnar
Panos
P
Deloukas
Patrick
P
Sulem
Hreinn
H
Stefansson
Kari
K
Stefansson
Tim D
TD
Spector
Vincent
V
Mooser
D000505:Alopecia / Q000235:genetics*; D002890:Chromosomes, Human, Pair 20 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D015894:Genome, Human / Q000235:genetics; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics