Efficacy of ciprofloxacin and moxifloxacin against Nocardia brasiliensis in vitro and in an experimental model of actinomycetoma in BALB/c mice.
The efficacy of ciprofloxacin and moxifloxacin against Nocardia brasiliensis was evaluated by applying 25 mg of each drug/kg subcutaneously every 8 h in BALB/c mice infected with N. brasiliensis. A statistically significant difference was observed only with moxifloxacin. A moxifloxacin-trimethoprim-sulfamethoxazole combination was as active as when each compound was used alone.
Servicio de Dermatología, Hospital Universitario José E. González, Monterrey, NL, Mexico.
Brenda Edith
BE
Chacon-Moreno
Oliverio
O
Welsh
Norma
N
Cavazos-Rocha
Maria
M
de la Luz Salazar-Cavazos
Hector Gerardo
HG
Garza-Lozano
Salvador
S
Said-Fernandez
Jorge
J
Ocampo-Candiani
Lucio
L
Vera-Cabrera
D000818:Animals; D001372:Aza Compounds / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D004195:Disease Models, Animal; D005260:Female; D024841:Fluoroquinolones; D051379:Mice; D008807:Mice, Inbred BALB C; D008826:Microbial Sensitivity Tests; D000077266:Moxifloxacin; D008271:Mycetoma / Q000188:drug therapy* / Q000382:microbiology*; D009615:Nocardia / Q000187:drug effects* / Q000472:pathogenicity*; D011804:Quinolines / Q000494:pharmacology*
D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D002939:Ciprofloxacin; D000077266:Moxifloxacin