3-Amino-2(5H)furanones as inhibitors of subgenomic hepatitis C virus RNA replication.
A new class of compounds able to block the replication of subgenomic HCV RNA in liver cells is described. 3-Amino-2(5H)furanones 4 may be regarded as diketoacid analogues and were obtained by basic rearrangement of the isoxazolidine nucleus.
Iannazzo
Daniela
D
Dipartimento Farmaco-Chimico, Università di Messina, Via SS. Annunziata, Messina 98168, Italy. UUdiannazzo@pharma.unime.itUU
Piperno
Anna
A
Romeo
Giovanni
G
Romeo
Roberto
R
Chiacchio
Ugo
U
Rescifina
Antonio
A
Balestrieri
Emanuela
E
Macchi
Beatrice
B
Mastino
Antonio
A
Cortese
Riccardo
R
D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000821:virology; D049109:Cell Proliferation / Q000187:drug effects; D005663:Furans / Q000138:chemical synthesis / Q000494:pharmacology*; D016679:Genome, Viral; D016174:Hepacivirus / Q000187:drug effects* / Q000235:genetics; D006526:Hepatitis C / Q000188:drug therapy / Q000821:virology; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000821:virology*; D015394:Molecular Structure; D012367:RNA, Viral / Q000235:genetics*; D012093:Replicon / Q000187:drug effects*; D014407:Tumor Cells, Cultured; D017361:Viral Nonstructural Proteins / Q000235:genetics; D014779:Virus Replication / Q000187:drug effects*; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases
D000998:Antiviral Agents; D005663:Furans; D012367:RNA, Viral; D017361:Viral Nonstructural Proteins; C535188:2,5-dihydro-2-methyl-4-(methylamino)-5-oxo-N-phenylfuran-3-carboxamide; C084422:NS3 protein, hepatitis C virus; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases