A novel report of cig-FISH and cytogenetics in POEMS syndrome.
POEMS syndrome is a plasma cell proliferative disorder whose pathogenesis is poorly understood. We provide the first report of cytoplasmic immunoglobulin/FISH testing (cIg-FISH) in POEMS syndrome using established myeloma markers. We reviewed all 37 POEMS cases seen at our institution in which cIg-FISH testing had been obtained. Monosomy 13 was seen in 14 of the 37 (38%) cIg-FISH samples. One patient had trisomy 3 and 7. Three patients had IgH translocation t(11;14)(q13;q32). No abnormalities were seen at 17p13(p53). The monosomy 13 is in line with other plasma cell disorders while the low prevalence of hyperdiploidy and abnormalities at 14q32 is unique.
Bryce
Alan H
AH
Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Ketterling
Rhett P
RP
Gertz
Morie A
MA
Lacy
Martha
M
Knudson
Ryan A
RA
Kumar
Shaji
S
Kyle
Robert A
RA
Fonseca
Rafael
R
Greipp
Phillip R
PR
Lust
John A
JA
Rajkumar
Vincent S
VS
Hayman
Suzanne R
SR
Buadi
Francis
F
Russell
Stephen J
SJ
Zeldenrust
Stephen R
SR
Dispenzieri
Angela
A
D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics; D015331:Cohort Studies; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D016878:POEMS Syndrome / Q000235:genetics*