Leaving home early: reexamination of the canonical models of tumor progression.
A recent report in Science from the Varmus laboratory (Podsypanina et al., 2008) puts an interesting twist on the origins of metastatic cells, suggesting that metastases can arise in ways that are very different from those widely believed.
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA. weinberg@wi.mit.edu
Robert A
RA
Weinberg
D000818:Animals; D049109:Cell Proliferation; D002470:Cell Survival; D002471:Cell Transformation, Neoplastic / Q000378:metabolism / Q000473:pathology; D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism / Q000556:secondary*; D008321:Mammary Glands, Animal / Q000378:metabolism / Q000473:pathology*; D008325:Mammary Neoplasms, Experimental / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D009362:Neoplasm Metastasis; D009366:Neoplasm Seeding; D009360:Neoplastic Cells, Circulating / Q000378:metabolism / Q000473:pathology*; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics / Q000378:metabolism*; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics / Q000378:metabolism*
D016271:Proto-Oncogene Proteins c-myc; D016283:Proto-Oncogene Proteins p21(ras)