Paraneoplastic chronic demyelinating neuropathy and Lambert-Eaton myasthenic syndrome associated with multiple anti-neural antibodies and small-cell lung cancer.
Lambert-Eaton myasthenic syndrome (LEMS) developed in a patient with presumed chronic inflammatory demyelinating polyneuropathy (CIDP) and negative chest CT. Since antibodies against both Hu and voltage-gated calcium channel (VGCC) were detected, repeated chest CT was performed, which eventually showed a pulmonary mass lesion. Biopsy revealed small cell lung cancer (SCLC) indicating the importance of repeated chest CT in LEMS even when an existing autoimmune-like disease and negative CT may suggest an autoimmune origin. This is the first report of paraneoplastic CIDP and LEMS associated with anti-Hu, anti-VGCC and SCLC.
Jahn Ferenc Teaching Hospital, Budapest.
Csilla
C
Rozsa
Angela
A
Vincent
Zsuzsanna
Z
Aranyi
Gabor G
GG
Kovacs
Samuel
S
Komoly
Zsolt
Z
Illes
D018288:Carcinoma, Small Cell / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D003711:Demyelinating Diseases / Q000209:etiology* / Q000276:immunology; D051959:ELAV Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D015624:Lambert-Eaton Myasthenic Syndrome / Q000209:etiology* / Q000276:immunology; D008175:Lung Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D008875:Middle Aged; D020361:Paraneoplastic Syndromes, Nervous System / Q000209:etiology* / Q000276:immunology
D051959:ELAV Proteins