Ovarian suppression in the management of premenopausal breast cancer: methods and efficacy in adjuvant and metastatic settings.
Ovarian suppression has been used to treat hormone-responsive metastatic breast cancer in premenopausal women for over 100 years and is currently under continued evaluation for treatment in the adjuvant setting. In this article, ovarian suppression by surgery, radiation, and pharmacological therapy is discussed, including the risks, benefits, and efficacy of each strategy. The role of ovarian suppression in premenopausal women with early and advanced stages of breast cancer will be reviewed. It is hoped that this review will assist clinicians and their patients in selecting the appropriate therapy if ovarian suppression is indicated.
McDonald Wade
Seaborn
S
Hematology/Oncology and Palliative Care, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, USA.
Hackney
Mary Helen
MH
Khatcheressian
James
J
Lyckholm
Laurie J
LJ
D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000556:secondary / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D009376:Neoplasms, Hormone-Dependent / Q000473:pathology / Q000628:therapy*; D010052:Ovariectomy; D010053:Ovary / Q000187:drug effects* / Q000528:radiation effects*; D017697:Premenopause
D018931:Antineoplastic Agents, Hormonal