An endoplasmic reticulum (ER) stress-suppressive compound and its analogues from the mushroom Hericium erinaceum.
Three new compounds, 3-hydroxyhericenone F (1), hericenone I (2), and hericenone J (3), were isolated from the mushroom Hericium erinaceum. The structures of 1-3 were determined by the interpretation of spectral data. Compound 1 showed the protective activity against endoplasmic reticulum (ER) stress-dependent Neuro2a cell death, however, compounds 2 and 3 did not.
Graduate School of Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan.
Keiko
K
Ueda
Megumi
M
Tsujimori
Shinya
S
Kodani
Akiko
A
Chiba
Masakazu
M
Kubo
Kazuhiko
K
Masuno
Atsushi
A
Sekiya
Kaoru
K
Nagai
Hirokazu
H
Kawagishi
D000363:Agaricales / Q000737:chemistry*; D000818:Animals; D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D004721:Endoplasmic Reticulum / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D015394:Molecular Structure; D009447:Neuroblastoma / Q000378:metabolism / Q000473:pathology; D010636:Phenols / Q000737:chemistry* / Q000494:pharmacology
C535183:3-hydroxyhericenone F; D001688:Biological Products; D010636:Phenols; C535185:hericenone I; C535186:hericenone J