Sodium-lithium countertransport activity in healthy, dyslipidemic, and hypertensive individuals.
The aim of our study was to investigate the role of dyslipidemia on red blood cell sodium-lithium countertransport activity in healthy and hypertensive individuals. A total of 128 Caucasian individuals, aged 20 to 60 years old, were divided into 4 groups: dyslipidemic/ hypertensive, dyslipidemic/normotensive, normolipidemic/hypertensive, and normolipidemic/ normotensive (controls). Sodium-lithium countertransport activity was determined based on the Canessa et al method. Sodium-lithium countertransport activity was significantly higher in all patient groups compared with controls (P < .001) and similar in the 3 patient groups. Sodium-lithium countertransport activity was significantly and positively associated with triglyceride levels (P < .001), body mass index (P < .001), total cholesterol levels (P = .001), and systolic (P = .001) and diastolic blood pressure (P = .001). In multivariate regression analysis, triglycerides made the largest contribution to sodium-lithium countertransport variation among the variables tested (R(2) = 0.273). Our results suggest that dyslipidemia affects sodium-lithium countertransport activity independently of essential hypertension and even to a greater extent than hypertension.
1st Propedeutic Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, Greece.
Christos G
CG
Savopoulos
Apostolos I
AI
Hatzitolios
Niki A
NA
Katsiki
Maria
M
Baltatzi
Maria
M
Kosmidou
Nikolaos
N
Raikos
Dimitri P
DP
Mikhailidis
Antonios G
AG
Ziakas
Georgia
G
Kaiafa
Niki
N
Tsesmeli
D000328:Adult; D017920:Antiporters / Q000097:blood*; D001794:Blood Pressure; D015992:Body Mass Index; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D050171:Dyslipidemias / Q000097:blood* / Q000503:physiopathology; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood; D015854:Up-Regulation; D055815:Young Adult
D017920:Antiporters; D014280:Triglycerides; C045885:sodium-lithium countertransporter; D002784:Cholesterol