Chicoric acid, a new compound able to enhance insulin release and glucose uptake.
Caffeic acid and chlorogenic acid (CGA), a mono-caffeoyl ester, have been described as potential antidiabetic agents. Using in vitro studies, we report the effects of a dicaffeoyl ester, chicoric acid (CRA) purified from Cichorium intybus, on glucose uptake and insulin secretion. Our results show that CRA and CGA increased glucose uptake in L6 muscular cells, an effect only observed in the presence of stimulating concentrations of insulin. Moreover, we found that both CRA and CGA were able to stimulate insulin secretion from the INS-1E insulin-secreting cell line and rat islets of Langerhans. In the later case, the effect of CRA is only observed in the presence of subnormal glucose levels. Patch clamps studies show that the mechanism of CRA and CGA was different from that of sulfonylureas, as they did not close K(ATP) channels. Chicoric acid is a new potential antidiabetic agent carrying both insulin sensitizing and insulin-secreting properties.
Faculté de Pharmacie, Centre de Pharmacologie & Innovation dans le Diabète, CNRS UMR 5232, Université Montpellier 1, Montpellier cedex 5, France. didier.tousch@univ-montp1.fr
Didier
D
Tousch
Anne-Dominique
AD
Lajoix
Eric
E
Hosy
Jacqueline
J
Azay-Milhau
Karine
K
Ferrare
Céline
C
Jahannault
Gérard
G
Cros
Pierre
P
Petit
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002109:Caffeic Acids / Q000494:pharmacology*; D002460:Cell Line; D018651:Cichorium intybus / Q000737:chemistry; D002726:Chlorogenic Acid / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism; D054086:KATP Channels / Q000037:antagonists & inhibitors; D032342:Muscle Cells / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D013386:Succinates / Q000494:pharmacology*; D014981:Xenopus
D002109:Caffeic Acids; D007004:Hypoglycemic Agents; D007328:Insulin; D054086:KATP Channels; D013386:Succinates; D002726:Chlorogenic Acid; D005947:Glucose; C100435:chicoric acid