Complete absolute configuration of integramide A, a natural, 16-mer peptide inhibitor of HIV-1 integrase, elucidated by total synthesis.
De Zotti
Marta
M
Institute of Biomolecular Chemistry, CNR, Padova Unit, Department of Chemistry, University of Padova, Padua, Italy.
Formaggio
Fernando
F
Kaptein
Bernard
B
Broxterman
Quirinus B
QB
Felock
Peter J
PJ
Hazuda
Daria J
DJ
Singh
Sheo B
SB
Brückner
Hans
H
Toniolo
Claudio
C
D000595:Amino Acid Sequence; D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D019427:HIV Integrase / Q000378:metabolism*; D019428:HIV Integrase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013237:Stereoisomerism
D001688:Biological Products; D019428:HIV Integrase Inhibitors; D009842:Oligopeptides; C456979:integramide A; D019427:HIV Integrase; C514801:p31 integrase protein, Human immunodeficiency virus 1