The evolution of biomarkers in rheumatoid arthritis: from clinical research to clinical care.
BACKGROUND
Treatment efficacy in rheumatoid arthritis (RA) has been measured by clinical response, gross radiological results and some biochemical markers. With the new biologic treatments, markers for disease development, progress, severity and therapy response have evolved.


OBJECTIVE
This review focuses on a selection of current markers and the need for better markers for determining RA treatment susceptibility and success.


METHODS
A review of the literature was conducted and expert opinions expressed.


CONCLUSIONS
Current biomarkers mainly focus on disease activity and severity. Biomarkers for treatment response and susceptibility that help clinicians make initial treatment decisions are lacking or insufficient, yet required for optimal control of RA. A combination of biomarkers is necessary to classify a complex immune disease, such as RA.
van den Broek
Theodorus
T
University of Arizona, Arizona Arthritis Center, Tucson, Arizona 85724-5093, USA.
Tesser
John R P
JR
Albani
Salvatore
S
D000818:Animals; D018501:Antirheumatic Agents / Q000494:pharmacology; D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D001323:Autoantibodies / Q000737:chemistry; D015415:Biomarkers / Q000378:metabolism*; D002356:Cartilage / Q000378:metabolism; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D007107:Immune System; D007249:Inflammation; D012219:Rheumatology / Q000379:methods; D013583:Synovial Membrane / Q000378:metabolism; D016896:Treatment Outcome
D018501:Antirheumatic Agents; D001323:Autoantibodies; D015415:Biomarkers; D005819:Genetic Markers