Long-term survival and prognostic indicators in small (<or=2 cm) pancreatic cancer.
OBJECTIVE
In a matched analysis, we investigated clinical, histopathological, and survival characteristics of small (<or=2 cm) pancreatic cancer (PaC) as compared to large PaC.


METHODS
From the Mayo pathology database, we identified 41 consecutive patients with small PaC and 94 matched controls with margin-negative PaC >2 cm. Two experienced pathologists, who were blinded to survival data, independently reviewed tumor stage and differentiation. Kaplan-Meier survival analysis and Cox proportional hazards models were applied for data analyses.


RESULTS
In patients with localized disease (stages I and II), survival was similar in small and large PaC but survival was significantly better in small PaC with regional nodal metastasis (stage III) as compared to similar stage large PaC (5-year survival 44 vs. 7%, median survival 58 vs.18 months, p < 0.001). Well-differentiated small and large PaC had similar median survival (76 vs. 74 months, p = NS). In multivariate analysis, tumor differentiation, not tumor size, was the only independent factor predicting survival in PaC (risk ratio, RR, for moderate vs. well- differentiated: 2.6, 95% confidence interval, CI, 1.5-4.5, and RR for poorly differentiated vs. well-differentiated: 5.0, 95% CI 2.4-10.1).


CONCLUSIONS
Tumor differentiation may be a better predictor of survival in resectable PaC than tumor stage.
Division of Gastroenterology, Mayo Clinic, Rochester, MN 55905, USA.
Supot
S
Pongprasobchai
Rahul
R
Pannala
Thomas C
TC
Smyrk
William
W
Bamlet
Suresh
S
Pitchumoni
Andrei
A
Ougolkov
Mariza
M
de Andrade
Gloria M
GM
Petersen
Suresh T
ST
Chari
D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000628:therapy; D011379:Prognosis; D018714:Radiotherapy, Adjuvant
D000970:Antineoplastic Agents