[Fisher syndrome with optic neuropathy].
Fisher syndrome with optic neuropathy has been rarely reported. We report a 78-year-old Frenchman with Fisher syndrome. The patient complained of dizziness and bilateral blurred vision. His corrected visual acuity was 0.03 in the right eye, and 0.02 in the left eye. Deep tendon reflexes were absent. A few days later, bilateral complete external ophthalmoplegia appeared. Both pupils were dilated and pupillary reflexes were absent. Serum anti-GQlb antibodies and anti-GT1a antibodies were detected. After intravenous immunoglobulin treatments, all neurological symptoms including optic neuropathy and external ophthalmoplegia disappered except for pupillary dilatation associated with light-near dissociation. Tonic pupil indicated disorder of the peripheral nervous system.


CONCLUSIONS
Fisher syndrome may complicate optic neuropathy.
Division of Ophthalmology, Department of Comprehensive Medical Sciences, Meikai University School of Dentistry. 1-1 Keyakidai, Sakado, Saitama 350-0283, Japan. norikoga@dent-meikai.ac.jp
Noriko
N
Koga
Hiroshi
H
Ishikawa
Yuu
Y
Itou
Masayuki
M
Minami
Tomohiko
T
Mizutani
D000368:Aged; D015415:Biomarkers / Q000097:blood; D005732:Gangliosides / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D019846:Miller Fisher Syndrome / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D009901:Optic Nerve Diseases / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D016896:Treatment Outcome
D015415:Biomarkers; D005732:Gangliosides; D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous; C039129:GQ1b ganglioside