A simple one-pot preparation of diazoacetoacetate derivatives from aldehydes.
Diazoacetoacetate derivatives can be simply and efficiently prepared from aldehydes in a one-pot process involving initial DBU-promoted "aldol" condensation with ethyl diazoacetate followed by in situ oxidation with IBX. Aryl, alkyl, and unsaturated aldehydes are all viable substrates.
Department of Chemistry, University of Durham, Science Laboratories, South Road, Durham DH1 3LE, UK.
Marvis O
MO
Erhunmwunse
Patrick G
PG
Steel