[Effect of scavenger receptor class A type I/II on lipid metabolism in mice].
OBJECTIVE
To observe the effects of scavenger receptor class A type I/II on lipid metabolism in mice.


METHODS
TG, TC, HDL-C, LDL-C, and ApoB levels, were measured by enzymatic determination. Lipid accumulation in mice liver was analyzed by the lipid-specific Oil Red O-positive staining of frozen liver sections.


RESULTS
The levels of serum TG, TC, LDL-C and ApoB of SR-A I/II knockout mice were more higher than those of wild type mice (P < 0.01). The histological analyses revealed hepatocytes SR-A I/II deficient mice were distended and massive lipids SR-A I/II deficient mice accumulated in liver, and both SR-A I/II deficient mice were more severer than those of the wild type mice.


CONCLUSIONS
Scavenger receptor class A type I/II could play an important role in regulation of lipid metabolism in mice.
Liu
Mingbin
M
Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. mingbinliu@126.com
Ling
Wenhua
W
Yu
Xiaoping
X
D000818:Animals; D050356:Lipid Metabolism / Q000502:physiology*; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D051117:Scavenger Receptors, Class A / Q000235:genetics / Q000378:metabolism*
D051117:Scavenger Receptors, Class A