Iridium-catalyzed asymmetric ring-opening reactions of N-Boc-azabenzonorbornadiene with secondary amine nucleophiles.
Iridium-catalyzed asymmetric ring-opening reactions of N-Boc-azabenzonorbornadiene with a number of secondary amines has been developed for the first time. The reaction gave 1,2-trans-diamine derivatives in moderate to good yields with high enantioselectivity in the presence of 2.5 mol % of [Ir(COD)Cl]2 and 5 mol % of (S)-BINAP. The trans-configuration of the 1,2-diamino products was confirmed by X-ray crystallography.
School of Chemistry and Environment, South China Normal University, Guangzhou 510006, China. yangdq@scnu.edu.cn
Dingqiao
D
Yang
Yuhua
Y
Long
Huan
H
Wang
Zhenming
Z
Zhang