[Neuraminidase inhibitors in prophylaxis and treatment of influenza].
Influenza is an acute infectious disease which may cause spectacular health, social and economic effects. Influenza may be prevented and treated in a sufficient way. The paper presents general rules of usage of current antiviral drugs--neuraminidase inhibitors--in prophylaxis and treatment of seasonal, avian and pandemic influenza. The paper describes mechanism of action of neuraminidase inhibitors (oseltamivir and zanamivir), their main pharmacokinetic features, dosing and side effects. There was emphasized the necessity of the early introduction of treatment with neuraminidase inhibitors (36-48 hours after first symptoms) and the short duration of treatment (5 days). It is also discussed the role of neuraminidase inhibitors in the clinical management of avian influenza (H5N1) and their role in fighting with a pandemic disease.
Nitsch-Osuch
Aneta
A
Department of Family Medicine, Medical University of Warsaw, Poland. anitsch@amwaw.edu.pl
Brydak
Lidia B
LB
Wardyn
Andrzej K
AK
D000998:Antiviral Agents / Q000627:therapeutic use*; D004196:Disease Outbreaks / Q000517:prevention & control*; D004334:Drug Administration Schedule; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype; D007251:Influenza, Human / Q000188:drug therapy* / Q000453:epidemiology; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D053139:Oseltamivir / Q000627:therapeutic use; D053243:Zanamivir / Q000627:therapeutic use
D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D053139:Oseltamivir; D009439:Neuraminidase; D053243:Zanamivir
Inhibitory neuraminidazy w profilaktyce i leczeniu grypy.