[Case report and literature review of epithelioid trophoblastic tumor].
OBJECTIVE
To evaluate the clinical characteristics of epithelioid trophoblastic tumor (ETT).


METHODS
Six cases of ETT treated in Women's Hospital, School of Medicine, Zhejiang University from 2005 to 2007 were retrospectively analyzed, together with a literature review.


RESULTS
Six cases of ETT were diagnosed pathologically after surgery. The age of patients ranged from 27 to 46 years. The most common presentation was abnormal vaginal bleeding (5/6). The preceding gestational events were hydatidiform mole in 1 case, abortion in 2 cases, and term delivery in 3 cases. The interval between the preceding gestation and the diagnosis of ETT ranged from 15-48 months. The serum human chorionic gonadotropin (hCG) level was 46-121.47 IU/L. Four cases presented with metastasis, including lung metastasis in all of the 4 cases, liver metastasis in 1 case, and pancreas metastasis in another 1 case. The main therapies were surgery combined with chemotherapy. All of the 6 cases received total abdominal hysterectomy, and 1 case also had lung lobectomy. One case had a recurrence but refused any treatment again, and was lost to follow up; the therapy of 1 case unfinished; another 4 cases were without evidence of disease 9 to 19 months after surgery.


CONCLUSIONS
The confirmation of ETT diagnosis is difficult before surgery. Surgical management is mostly recommended in ETT. The role of chemotherapy in ETT is not clear yet.
Cheng
Xiao-Dong
XD
Department of Oncological, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.
Lü
Wei-Guo
WG
Wan
Xiao-Yun
XY
Chen
Xiao-Duan
XD
Xie
Xing
X
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood; D006063:Chorionic Gonadotropin / Q000097:blood; D003131:Combined Modality Therapy; D015622:Epithelioid Cells / Q000473:pathology; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008175:Lung Neoplasms / Q000556:secondary / Q000628:therapy; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011247:Pregnancy; D011379:Prognosis; D012189:Retrospective Studies; D014328:Trophoblastic Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy*; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy*
D014408:Biomarkers, Tumor; D006063:Chorionic Gonadotropin