[Association between estrogen receptor beta gene polymorphisms and Parkinson disease].
OBJECTIVE
To investigate the association between two estrogen receptor (ER) beta gene polymorphisms and Parkinson disease (PD) as well as Parkinson disease with dementia (PDD) in Chinese people.


METHODS
Peripheral blood samples were collected from 115 PD patients (including 26 PDD cases), 56 males and 55 females, aged 64 +/- 10, and 116 sex and age-matched healthy controls. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to analyze the polymorphism of the fifth exon RsaI and the eighth exon AluI of ERbeta gene. Te relationship between each genotype or allele frequencies and PD/PDD was analyzed using chi-square test.


RESULTS
There was no difference in the polymorphism of ERbeta genes AluI and Rsa I between the PD group and control group and between the PDD group and control group (all P > 0.05).


CONCLUSIONS
Genetic variations from AluI and RsaI digestion in ERbeta gene do not affect the risk of PD and PDD.
Chen
Rong-Jie
RJ
Department of Neurology, General Hospital of Tianjin Medical University, Tianjin 300052, China. sue904crj@sohu.com
Zhang
Ben-Shu
BS
Wang
Shi-Min
SM
D000368:Aged; D001483:Base Sequence; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D047629:Estrogen Receptor beta / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
D047629:Estrogen Receptor beta