Lower airway disease in asthmatics with and without rhinitis.
OBJECTIVE
The purpose of this study was to determine if asthma with rhinitis and asthma without rhinitis represent distinct forms of disease.


METHODS
We performed a prospective cross-sectional study.


METHODS
The study included healthy controls, participants with asthma without rhinitis, and participants with both asthma and rhinitis. Interventions We compared lung function and airway inflammation between the three groups of participants.


RESULTS
We recruited 32 participants: 12 normals, 8 asthmatics without rhinitis, and 12 with rhinitis. Compared to asthmatics with rhinitis, asthmatics without rhinitis had more severe airflow limitation (FEV(1)/FVC = 60.6% [IQR = 22.8] vs. 74.8% [IQR = 7.8] and fewer induced sputum eosinophils (2.8 [IQR = 5.8] and 9.6 [IQR = 23.8], respectively). Sputum interleukin-6 correlated inversely with lung function measured by postbronchodilator FEV(1) in the study cohort (Spearman correlation coefficient = -0.55, p < 0.01).


CONCLUSIONS
Asthmatics without rhinitis tend to have lower lung function and less eosinophilic inflammation in the lung. This small study suggests that asthmatics without rhinitis represent a distinct phenotype of asthma in which low lung function is dissociated from eosinophilic cellular inflammation, and it suggests that larger studies addressing this phenotype are warrented.
Dixon
Anne E
AE
Department of Medicine, University of Vermont College of Medicine, Vermont Lung Center, HSRF 226, 149 Beaumont Avenue, Burlington, VT 05405, USA. Anne.dixon@uvm.edu
Raymond
Danielle M
DM
Suratt
Benjamin T
BT
Bourassa
Lorraine M
LM
Irvin
Charles G
CG
D000328:Adult; D001249:Asthma / Q000145:classification / Q000276:immunology / Q000503:physiopathology*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000503:physiopathology; D015850:Interleukin-6 / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000032:analysis / Q000378:metabolism; D010641:Phenotype; D011446:Prospective Studies; D012129:Respiratory Function Tests; D012137:Respiratory System / Q000276:immunology / Q000503:physiopathology; D012220:Rhinitis / Q000145:classification / Q000276:immunology / Q000503:physiopathology*; D013183:Sputum / Q000737:chemistry / Q000276:immunology
D015850:Interleukin-6; D009569:Nitric Oxide