NODAPA-OH and NODAPA-(NCS)n: synthesis, 68Ga-radiolabelling and in vitro characterisation of novel versatile bifunctional chelators for molecular imaging.
This report concerns synthesis, (68)Ga-radiolabelling and stability data of 1,4,7-triazacyclononane-1,4-diacetic acid-7-p-isothio-cyanatophenyl-acetic acid (NODAPA-NCS), 1,4,7-triazacyclononane-1-acetic acid-4,7-di-p-isothiocyanatophenyl-acetic acid (NODAPA-(NCS)(2)) and 1,4,7-triazacyclononane-1,4-diacetic acid-7-p-hydroxyphenyl-acetic acid (NODAPA-OH), versatile bifunctional chelators with potential for molecular imaging. Protein binding and exemplified conjugation are also reported.
Institute of Nuclear Chemistry, University of Mainz, Fritz-Strassmann-Weg 2, 55128 Mainz, Germany.
Patrick J
PJ
Riss
Carsten
C
Kroll
Verena
V
Nagel
Frank
F
Rösch
D002614:Chelating Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D005710:Gallium Radioisotopes / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry; D006573:Heterocyclic Compounds, 1-Ring / Q000138:chemical synthesis*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007553:Isotope Labeling / Q000379:methods; D008956:Models, Chemical; D010648:Phenylacetates / Q000737:chemistry; D049268:Positron-Emission Tomography / Q000295:instrumentation* / Q000379:methods; D011868:Radioisotopes / Q000737:chemistry*
C540064:1,4,7-triazacyclononane-1,4-diacetic acid-7-p-hydroxyphenylacetic acid; C540062:1,4,7-triazacyclononane-1,4-diacetic acid-7-p-isothiocyanatophenylacetic acid; C540063:1,4,7-triazacyclononane-1-acetic acid-4,7-di-p-isothiocyanatophenylacetic acid; D002614:Chelating Agents; D005710:Gallium Radioisotopes; D006571:Heterocyclic Compounds; D006573:Heterocyclic Compounds, 1-Ring; D010648:Phenylacetates; D011868:Radioisotopes; C048993:1,4,7-triazacyclononane-N,N',N''-triacetic acid