Biophysical correlates of cognition among depressed and nondepressed type 2 diabetic patients.
OBJECTIVE
Caudate magnetization transfer (MT) ratios have indicated an abnormality in the macromolecular protein pool of diabetic patients. This study examined the relationship between MT ratios of the caudate and cognitive performance.


METHODS
Diabetic patients, diabetic and depressed patients, and healthy comparison subjects completed magnetic resonance imaging and a neuropsychological battery. Magnetization transfer ratios of caudate and three comparison regions were computed. The neuropsychological battery was aggregated into a global index of cognitive function and correlated with MT ratios.


RESULTS
MT ratios of the caudate correlated with cognitive performance, and the correlations were stronger among diabetic patients than healthy control subjects. Comorbid depression increased the strength of the correlation compared with diabetes alone. Comparison regions showed no evidence of a diabetes effect on cognition.


CONCLUSIONS
One mechanism precipitating cognitive loss during diabetes appears to be associated with cellular changes occurring in the macromolecular protein pool of the caudate.
Semel Institute for Neuroscience and Human Behavior, Geriatric Division, University of California, Los Angeles, California, USA. velderkin@mednet.ucla.edu
Virginia
V
Elderkin-Thompson
Gerhard
G
Hellemann
Rakesh K
RK
Gupta
Anand
A
Kumar
D017668:Age of Onset; D000368:Aged; D002421:Caudate Nucleus / Q000033:anatomy & histology / Q000473:pathology / Q000502:physiology / Q000503:physiopathology*; D003071:Cognition; D003072:Cognition Disorders / Q000209:etiology; D003863:Depression / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology / Q000523:psychology*; D005260:Female; D006304:Health Status; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011699:Putamen / Q000033:anatomy & histology / Q000473:pathology / Q000502:physiology / Q000503:physiopathology