Manganese-based nanoscale metal-organic frameworks for magnetic resonance imaging.
Manganese-containing nanoscale metal-organic frameworks (NMOFs) with controllable morphologies were synthesized using reverse-phase microemulsion techniques at room temperature and a surfactant-assisted procedure at 120 degrees C with microwave heating. The nanoparticles were characterized using a variety of methods including SEM, TEM, TGA, PXRD, and ICP-MS. Although the nanoparticles gave a modest longitudinal relaxivity (r1) on a per Mn basis, they provided an efficient vehicle for the delivery of large doses of Mn2+ ions which exhibited very high in vitro and in vivo r1 values and afforded excellent MR contrast enhancement. The particle surface was also modified with a silica shell to allow covalent attachment of a cyclic RGD peptide and an organic fluorophore. The cell-targeting molecules on the Mn NMOFs enhanced their delivery to cancer cells to allow for target-specific MR imaging in vitro. The MR contrast enhancement was also demonstrated in vivo using a mouse model. Such core-shell hybrid nanostructures provide an ideal platform for targeted delivery of other imaging and therapeutic agents to diseased tissues.
Department of Chemistry, CB#3290, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Kathryn M L
KM
Taylor
William J
WJ
Rieter
Wenbin
W
Lin
D000818:Animals; D019073:HT29 Cells; D006801:Humans; D008024:Ligands; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008345:Manganese / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D008872:Microwaves; D009842:Oligopeptides / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry; D012235:Rhodamines / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry; D014233:Tricarboxylic Acids / Q000737:chemistry
D008024:Ligands; D009842:Oligopeptides; D009942:Organometallic Compounds; D012235:Rhodamines; D013501:Surface-Active Agents; D014233:Tricarboxylic Acids; D008345:Manganese; D012822:Silicon Dioxide; C047981:arginyl-glycyl-aspartic acid; C029773:rhodamine B; C069849:trimesic acid