The use of the Ki-67 marker in the pathological diagnosis of the epithelioid variant of renal angiomyolipoma.
OBJECTIVE
Epithelioid angiomyolipoma (EAML) is a rare malignant variant of renal angiomyolipoma (AML). There were 34 cases of EAML reported in 25 studies (including this present study) over the past decade. About 68% were females and 32% males. The mean age was 40.1 years, 53% developed metastatic disease after nephrectomy, and eight patients had TSC. All cases are reported positive when stained with HMB-45 which also labels all classical AML. This study evaluates the use of Ki-67 (proliferation marker) in the pathological diagnosis of EAML and distinction from classical AML.


METHODS
Immunohistochemical reactions for Ki-67 were generated on multiple representative blocks of tissue obtained from two cases of HMB-45 positive EAML and four cases of classic AML and the percentage of positively staining cells estimated.


RESULTS
Both cases of EAML were strongly positive for Ki-67 while all four classic AML were completely negative.


CONCLUSIONS
The Ki67 is a useful marker in which distinguishes the malignant epithelioid variant of AML from classic AML.
Ooi
Sue Min
SM
Department of Urology, Royal Perth Hospital, Perth, Australia. sueminooi@yahoo.com
Vivian
Justin B
JB
Cohen
Ronald J
RJ
D000328:Adult; D018207:Angiomyolipoma / Q000737:chemistry* / Q000473:pathology*; D015415:Biomarkers / Q000032:analysis; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis*; D007680:Kidney Neoplasms / Q000737:chemistry* / Q000473:pathology*; D008297:Male; D055815:Young Adult
D015415:Biomarkers; D019394:Ki-67 Antigen