A computer model of the Bystander effect: effects of individual behaviours on the population response.
A computer program was written to test assumptions on the mechanisms of response of cells to radiation. Current assumptions were implemented in the model and simulations were run to predict the survival of the hamster cell line V79 to irradiation with focused C(K) X-rays, 250 keV X-rays or 3.2 MeV protons. The model could reproduce the different types of response and support the idea that the response at low doses is non-linear and may be independent of LET.
Surrey Ion Beam Centre, Advanced Technology Institute, University of Surrey, Guildford, GU2 7XH, UK. m.richard@surrey.ac.uk
M
M
Richard
R P
RP
Webb
K J
KJ
Kirkby
N F
NF
Kirkby
D000818:Animals; D024201:Bystander Effect; D002470:Cell Survival / Q000528:radiation effects*; D003198:Computer Simulation; D006224:Cricetinae; D004307:Dose-Response Relationship, Radiation; D011522:Protons; D014965:X-Rays
D011522:Protons