Ovarian large cell neuroendocrine carcinoma.
Ovarian large cell neuroendocrine carcinoma (LCNC) is a rare disease that is commonly associated with a surface epithelial and germ cell neoplasm component. A 46-year-old woman presented with a pelvic mass measuring 15 cm in diameter. She underwent an exploratory laparotomy with resection of the pelvic mass. Diffuse and nodular intra-abdominal disseminations were observed. Stage III LCNC associated with squamous differentiation alone of the right ovary was diagnosed. The patient died of progressive disease 4 months postoperatively despite paclitaxel and carboplatin therapy. Ovarian LCNC associated with squamous differentiation component alone has never been reported, but its prognosis may be poor.
Department of Reproductive Pathophysiology and Obstet-Gynecology, Kagoshima University, Sakuragaoka, Kagoshima, Japan. tsujita@m3.kufm.kagoshima-u.ac.jp
Takahiro
T
Tsuji
Shinichi
S
Togami
Nao
N
Shintomo
Nobuyuki
N
Fukamachi
Tsutomu
T
Douchi
Shuuhei
S
Taguchi
D018278:Carcinoma, Neuroendocrine / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology*; D010053:Ovary / Q000473:pathology*