Sequences and polymorphisms of the canine monoamine transporter genes SLC6A2, SLC6A3, and SLC6A4 among five dog breeds.
Monoamine transporters have roles to regulate the monoamine concentrations in synaptic clefts in the central nervous system and are the targets of antidepressants and psychostimulants. They include transporters for norepinephrine, dopamine and serotonin, which are encoded by the SLC6A2, SLC6A3, and SLC6A4 genes, respectivily. We sequenced the full lengths of the coding regions of these genes for dogs and identified four single nucleotide polymorphisms (SNPs) in SLC6A2 and four in SLC6A3. One SLC6A3 SNP was non-synonymous and caused an amino acid substitution from threonine to serine. The genotype frequencies of these polymorphisms differed significantly among five breeds with different behavioral traits, suggesting that novel SLC6A2 and SLC6A3 SNPs would provide additional useful information for behavioral genetic studies in dogs.
Laboratory of Veterinary Ethology, The University of Tokyo, Tokyo, Japan.
Sayaka
S
Arata
Niwako
N
Ogata
Michito
M
Shimozuru
Yukari
Y
Takeuchi
Yuji
Y
Mori
D000818:Animals; D001483:Base Sequence; D017931:DNA Primers / Q000235:genetics; D004285:Dogs / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017422:Sequence Analysis, DNA; D013045:Species Specificity; D050493:Vesicular Monoamine Transport Proteins / Q000235:genetics*
D017931:DNA Primers; D050493:Vesicular Monoamine Transport Proteins