[Study on antitumor effect and its toxicity of Ipomoea Batatas Poir Cv anthocyanins].
OBJECTIVE
To investigate the antitumor effect and estimate the toxicity of Ipomoea Batatas Poir Cv anthocyanins.


METHODS
Mice sarcinoma S180 and mice liver cancer H22 were administered with positive Ftorafur and different dose of Ipomoea Batatas Poir Cv anthocyanins by pouring into the stomach. The antitumor effects of Ipomoea Batatas Poir Cv anthocyanins were observed by calculating the inhibition rate. Subchronic toxicity tests and micronucleus test of bone marrow cell in mice and Ames test were carried out to evaluate the toxicity.


RESULTS
At the doses of 150 mg and 75 mg Ipomoea Batatas Poir Cv anthocyanins, the rates of sarcinoma 180 inhibition were 45.04% and 36.64% respectively. The rate of liver cancer H22 inhibition at the dose of 150mg Batatas Poir Cv anthocyanins was 33.33% . The result of subchronic toxicity tests showed that Ipomoea Batatas Poir Cv anthocyanins had no obvious toxicity to rats. The results of the Ames test and micronucleus test were negative.


CONCLUSIONS
Ipomoea Batatas Poir Cv anthocyanins could have inhibitory effect on transplantation tumor of mice, and have no toxicity and no mutation.
Liu
Ning
N
Qingdao University, Qingdao 266071, China. qdliuning@126.com
Wang
Hongbing
H
Wang
Chunbo
C
D000818:Animals; D000872:Anthocyanins / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D027723:Ipomoea batatas / Q000737:chemistry*; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D018517:Plant Roots / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012510:Sarcoma 180 / Q000188:drug therapy; D018675:Toxicity Tests
D000872:Anthocyanins; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts