NF-kappaB signaling pathway and its therapeutic implications in human diseases.
The nuclear factor-kappaB (NF-kappaB) pathway is one of the most important cellular signal transduction pathways involved in both physiologic processes and disease conditions. It plays important roles in the control of immune function, inflammation, stress response, differentiation, apoptosis, and cell survival. Moreover, NF-kappaB is critically involved in the processes of development and progression of cancers. More importantly, recent studies have shown that NF-kappaB signaling also plays critical roles in the epithelial-mesenchymal transition (EMT) and cancer stem cells. Therefore, targeting of NF-kappaB signaling pathway could be a potent strategy for the prevention and/or treatment of human cancers and inflammatory diseases.
Sarkar
Fazlul H
FH
Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA. fsarkar@med.wayne.edu
Li
Yiwei
Y
Wang
Zhiwei
Z
Kong
Dejuan
D
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002454:Cell Differentiation; D002471:Cell Transformation, Neoplastic / Q000276:immunology; D002986:Clinical Trials as Topic; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000517:prevention & control; D008659:Metabolic Diseases / Q000378:metabolism* / Q000628:therapy; D051379:Mice; D016328:NF-kappa B / Q000276:immunology / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism* / Q000628:therapy; D018384:Oxidative Stress / Q000276:immunology; D051381:Rats; D015398:Signal Transduction; D015533:Transcriptional Activation
D000975:Antioxidants; D016328:NF-kappa B