Evaluation of the accuracy of intra-operative gross examination for the surgical management of endometrial cancer.
OBJECTIVE
The aim of this study was to explore the clinical value of intra-operative gross examination for the surgical management of endometrial carcinoma.


METHODS
A retrospective study was conducted in 424 women who underwent surgical treatment for endometrial carcinoma between January 2002 and December 2006. The results of myometrial invasion and cervical infiltration as assessed by intra-operative gross examination were compared with the final microscopic histopathological results in 401 patients. The accuracy, sensitivity, and specificity were calculated. Chi-squared or Fisher's exact tests were used for the comparison of categorical variables.


RESULTS
Intra-operative gross examination correctly identified the depth of microscopic myometrial invasion in 90.3% of patients. The sensitivity in detecting myometrial invasion was 80.6% and the specificity was 92.4%. With regard to cervical involvement, gross examination had an overall accuracy of 84.3%. The sensitivity in detecting cervical involvement was 32.6% and the specificity was 99.0%. Usually, cervical involvement cannot be correctly identified by intra-operative gross examination in patients with diffuse foci.


CONCLUSIONS
The data suggest that intra-operative gross examination is a simple and good method of predicting myometrial invasion, but it may not be the ideal way to assess cervical involvement in endometrial carcinoma.
Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Zhejiang University, Xueshi Road #2, Hangzhou 310006, People's Republic of China.
Yuyan
Y
Mao
Xiaoyun
X
Wan
Yaxia
Y
Chen
Weiguo
W
Lv
Xing
X
Xie
D002584:Cervix Uteri / Q000473:pathology*; D016889:Endometrial Neoplasms / Q000473:pathology*; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D008875:Middle Aged; D009215:Myometrium / Q000473:pathology*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D002583:Uterine Cervical Neoplasms / Q000473:pathology*