Personalized vaccines: the emerging field of vaccinomics.
The next 'golden age' in vaccinology will be ushered in by the new science of vaccinomics. In turn, this will inform and allow the development of personalized vaccines, based on our increasing understanding of immune response phenotype: genotype information. Rapid advances in developing such data are already occurring for hepatitis B, influenza, measles, mumps, rubella, anthrax and smallpox vaccines. In addition, newly available data suggest that some vaccine-related adverse events may also be genetically determined and, therefore, predictable. This paper reviews the basis and logic of personalized vaccines, and describes recent advances in the field.
Poland
Gregory A
GA
Mayo Clinic College of Medicine, Mayo Vaccine Research Group, Program in TranslationalImmunovirology and Biodefense, Mayo Clinic, Rochester, Minnesota 55905, USA. poland.gregory@mayo.edu
Ovsyannikova
Inna G
IG
Jacobson
Robert M
RM
D000486:Allergy and Immunology; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006680:HLA Antigens / Q000737:chemistry*; D006801:Humans; D007107:Immune System; D007115:Immunization Schedule; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic; D012737:Sex Factors; D014611:Vaccination; D014612:Vaccines / Q000737:chemistry*
D005819:Genetic Markers; D006680:HLA Antigens; D014612:Vaccines