Atrial and ventricular arryhthmogenic potential in Turner Syndrome.
BACKGROUND
P-wave dispersion (Pd), corrected P-wave dispersion (Pdc), QT-wave dispersion (QTd), and corrected QT-wave dispersion (QTdc) parameters were not assessed in Turner Syndrome (TS) before. The aim of this study is to investigate the cardiac arrhythmogenic potential in patients with TS.


METHODS
Thirty-one patients with TS and 30 healthy women were enrolled in the study. For this purpose 12-lead electrocardiogram (ECG) and 24-hour ambulatory ECG recordings were performed.


RESULTS
Pd, Pdc, QTd, and QTdc were significantly higher in patients with TS. On 24-hour ambulatory ECG recording, the mean heart rate (HR) was higher, while the mean of all RR intervals between normal beats (MeanNN), the standard deviation of all the RR intervals (SDNN), the square root of the mean of the squared differences of two consecutive RR intervals (rMSSD), and the percentage of the beats with consecutive RR interval difference more than 50 milliseconds (pNN50) were lower in TS.


CONCLUSIONS
There were significant increases in Pd, Pdc, QTd, and QTdc in patients with TS and they may be features of the disease. The frequency of supraventricular arrhythmias was increased. There also was a significant deterioration of sympathetic and parasympathetic components of autonomic function as assessed by heart rate variability (HRV) in Turner patients.
Sozen
Ahmet B
AB
Department of Cardiology, Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey. abilgesozen@hotmail.com
Cefle
Kivanç
K
Kudat
Hasan
H
Ozturk
Sukru
S
Oflaz
Huseyin
H
Pamukcu
Burak
B
Akkaya
Vakur
V
Isguven
Pinar
P
Palanduz
Sukru
S
Ozcan
Mustafa
M
Goren
Taner
T
Guven
Ozen
O
D000328:Adult; D001281:Atrial Fibrillation / Q000175:diagnosis* / Q000503:physiopathology*; D015716:Electrocardiography, Ambulatory / Q000706:statistics & numerical data; D005260:Female; D006339:Heart Rate; D006801:Humans; D014424:Turner Syndrome / Q000175:diagnosis* / Q000503:physiopathology*; D014693:Ventricular Fibrillation / Q000175:diagnosis* / Q000503:physiopathology*; D055815:Young Adult