[The clinical and laboratory features of 263 cases of chronic lymphocytic leukemia].
OBJECTIVE
To analyze the clinical and laboratory features of chronic lymphocytic leukemia (CLL).


METHODS
Retrospective investigation of 263 patients with CLL in our hospital between Feb. 2000 and Jan. 2007.


RESULTS
The median age was 60 years with male/female ratio of 2.17 : 1. Patients who were asymptomatic at diagnosis (35.4%) had low Rai grades. Fatigue and lymphadenopathy (54.8%) were the most common features at presentation. Infections, connective tissue diseases and secondary tumors frequently occurred in CLL. WBC counts were between (10 - 100) x 10(9)/L, with lymphocytes percentages more than 0.50 in 97.1% patients. Bone marrow was normal- to hyper-cellularity with lymphocytes percentages more than 0.300 in 99.4% patients. Diffuse infiltrations in bone marrow section were found in 72.2% patients. There were lower CD5 (85.1%) and higher CD25 (78.9%) positivities in the present series as compared with that in other reports. Hypogammaglobulinemia, especially hypo-IgM, usually occurred. Chromosome abnormality were rarely found by routine chromosome examination.


CONCLUSIONS
There were some clinical and laboratory characteristics different from that of abroad data. Further exploration of new markers is required for prognosis prediction and treatment choice.
Institute of Hematology and Blood Diseases Hospital, CAMS, Tianjin 300020, China.
Zeng-Jun
ZJ
Li
Lu-Gui
LG
Qiu
Tong
T
Wu
Ya-Fei
YF
Wang
De-Hui
DH
Zou
Yao-Zhong
YZ
Zhao
Jun-Yuan
JY
Qi
Ren-Chi
RC
Yang
Lin-Sheng
LS
Qian
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies