Highly enantio- and diastereoselective mannich reactions of chiral Ni(II) glycinates with amino sulfones. Efficient asymmetric synthesis of aromatic alpha,beta-diamino acids.
This paper describes a practical, enantio- and diastereoselective Mannich reaction between a chiral Ni(II) complex of glycine 1 and alpha-amino sulfones 2, involving the creation of a carbon-carbon bond and two stereogenic centers in a single operation; it represents an attractive route to the synthesis alpha,beta-diamino acids.
Wang
Jiang
J
Drug Discovery and Design Centre, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Graduate School, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
Shi
Ting
T
Deng
Guanghui
G
Jiang
Hualiang
H
Liu
Hong
H
D024322:Amino Acids, Aromatic / Q000138:chemical synthesis*; D005998:Glycine / Q000737:chemistry*; D009532:Nickel; D013237:Stereoisomerism; D013450:Sulfones / Q000737:chemistry*
D024322:Amino Acids, Aromatic; D013450:Sulfones; D009532:Nickel; D005998:Glycine