Seizure outcome following transcortical selective amygdalohippocampectomy in mesial temporal lobe epilepsy.
The aim of this study was to retrospectively determine if patients with medically refractory epilepsy, due to hippocampal sclerosis, who underwent selective amygdalohippocampectomy (SAH) with a transcortical approach experienced improved seizure outcome. Thirty-nine patients with mesial temporal lobe epilepsy and hippocampal sclerosis were included in the study. The mean follow-up was 25.88 +/- 17.69 months. Antiepileptic medication use and seizure frequency were significantly reduced after SAH. After surgery, 32 patients (82.05%) were completely seizure free (Engel class IA), and 2 patients experienced transient memory difficulty. In conclusion, SAH with a transcortical approach can lead to favorable seizure control with a low irreversible complication risk.
Department of Neurology, Pamukkale University, Denizli, Turkey.
Goksemin
G
Acar
Feridun
F
Acar
Jonathan
J
Miller
David C
DC
Spencer
Kim J
KJ
Burchiel
D000328:Adult; D000679:Amygdala / Q000473:pathology / Q000601:surgery*; D003399:Craniotomy / Q000379:methods*; D004833:Epilepsy, Temporal Lobe / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006624:Hippocampus / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures / Q000379:methods; D038361:Neuronavigation; D012189:Retrospective Studies; D012598:Sclerosis; D016896:Treatment Outcome