Serum lipid profile and plasma fatty acid composition in hemodialysis patients--comparison with chronic kidney disease patients.
Polyunsaturated fatty acids (PUFA) are reported to be associated with atherosclerotic and inflammatory diseases because they are the major components of the cytoplasmic membrane and are the precursor fatty acids for prostaglandins and leukotrienes. In the present study, the serum lipid profile and plasma fatty acid composition in hemodialysis (HD) patients were determined and compared with those in chronic kidney disease (CKD) patients. Seventeen HD patients (HD group) and 36 CKD patients (CKD group) were entered in the present study. The estimated glomerular filtration ratio (eGFR) in the CKD group was under 60 ml/min/1.73m2. In the analysis of the serum lipid profile, triglyceride concentrations in the HD group were significantly lower than those in the CKD group (90.9 +/- 41.0 mg/dl vs. 136.2 +/- 64.9 mg.dl, p = 0.011). In the analysis of the plasma fatty acid composition, alpha-linolenic acids (0.81 +/- 0.28% vs. 0.99 +/- 0.22%, p = 0.016), eicosapentaenoic acids (EPA) (2.31 +/- 0.89% vs. 3.24 +/- 1.79%, p = 0.048), docosahexaenoic acids (4.10 +/- 1.09% vs. 5.15 +/- 1.65%, p = 0.021), the ratios of EPA to arachidonic acids (0.458 +/- 0.195 vs. 0.727 +/- 0.438, p = 0.019), and the ratios of n-3 PUFA to n-6 PUFA (0.219 +/- 0.062 vs. 0.320 +/- 0.162, p = 0.017) in the HD group were significantly lower than those in the CKD group. These results suggest that there might be disorders not only in serum lipid metabolism but also in plasma fatty acid metabolism in HD patients.
Division of Cardiology, Respiratory and Nephrology, Hirosaki University Graduate School of Medicine, Aomori, Japan. nnakamur@r2.dion.ne.jp
Norio
N
Nakamura
Takeshi
T
Fujita
Ryuichiro
R
Kumasaka
Reiichi
R
Murakami
Michiko
M
Shimada
Yuko
Y
Shimaya
Hiroshi
H
Osawa
Hideaki
H
Yamabe
Ken
K
Okumura
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005227:Fatty Acids / Q000097:blood*; D005919:Glomerular Filtration Rate; D006801:Humans; D007674:Kidney Diseases / Q000097:blood* / Q000503:physiopathology / Q000628:therapy; D008055:Lipids / Q000097:blood*; D008875:Middle Aged; D006435:Renal Dialysis
D005227:Fatty Acids; D008055:Lipids