Total synthesis of citrafungin A.
The antifungal natural product citrafungin A was synthesized using, as key steps, an asymmetric aldol reaction of a chiral oxazolidinone, diastereoselective alkylation of a chiral 1,3-dioxolan-2-one, semihydrogenation of an enyne, and selective methyl ester deprotection.
Department of Chemistry, Imperial College London, Exhibition Road, London SW7 2AZ, England.
Frederick
F
Calo
Jeffery
J
Richardson
Anthony G M
AG
Barrett
D000447:Aldehydes / Q000737:chemistry; D000475:Alkenes / Q000138:chemical synthesis*; D000478:Alkylation; D000935:Antifungal Agents / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D007783:Lactones / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D013237:Stereoisomerism
D000447:Aldehydes; D000475:Alkenes; D000935:Antifungal Agents; D007202:Indicators and Reagents; D007783:Lactones; C485129:citrafungin A