1,2,3,4-Tetrahydro-8-hydroxyquinoline-promoted copper-catalyzed coupling of nitrogen nucleophiles and aryl bromides.
Based on the dramatic accelerating effect of 2-aminophenol, three ligands derived from 2-aminophenol were developed. Copper-catalyzed coupling reaction of nitrogen-containing nucleophiles with aryl bromides was efficiently carried out under mild conditions using 1,2,3,4-tetrahydro-8-hydroxyquinoline as a novel, simple, and versatile ligand.
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, China.
Huifeng
H
Wang
Yaming
Y
Li
Fangfang
F
Sun
Yang
Y
Feng
Kun
K
Jin
Xiuna
X
Wang
D000627:Aminophenols / Q000737:chemistry*; D001555:Benzene Derivatives / Q000737:chemistry*; D002384:Catalysis; D003300:Copper; D003432:Cross-Linking Reagents; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D006912:Hydroxyquinolines / Q000737:chemistry*; D009584:Nitrogen
D000627:Aminophenols; D001555:Benzene Derivatives; D003432:Cross-Linking Reagents; D006842:Hydrocarbons, Brominated; D006912:Hydroxyquinolines; C027667:2-aminophenol; D003300:Copper; D009584:Nitrogen