Tumor necrosis factor alpha-308 gene polymorphism and pseudoexfoliation glaucoma.
OBJECTIVE
To investigate the possible association between tumor necrosis factor alpha (TNF-alpha)-308 G/A polymorphism and pseudoexfoliation (PEX) glaucoma.


METHODS
One hundred and ten Turkish PEX glaucoma patients and 110 healthy control subjects were enrolled in the study. All participants underwent a complete ophthalmic examination. TNF-alpha-308 was genotyped by polymerase chain reaction and restriction endonuclease analysis.


RESULTS
We found a high prevalence of the G/G genotype in PEX glaucoma patients (OR=2.88, 95% CI 1.15-7.20). The A polymorphic allele frequency was 3.2% in patients with PEX compared with 8.2% in controls (p=0.023).


CONCLUSIONS
Our results suggest that TNF-alpha-308 G/A genotype is not associated with PEX glaucoma. The -308G/A variant may be a possible protective factor against PEX.
Department of Ophthalmology, Ankara University School of Medicine, Ankara, Turkey. oyatekeli@tr.net
Oya
O
Tekeli
M Erol
ME
Turacli
Yonca
Y
Egin
Nejat
N
Akar
Atilla Halil
AH
Elhan
D000368:Aged; D016022:Case-Control Studies; D017889:Exfoliation Syndrome / Q000150:complications* / Q000235:genetics*; D005260:Female; D005838:Genotype; D005901:Glaucoma / Q000150:complications* / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D014409:Tumor Necrosis Factor-alpha