FABSIM: a software for generating FST distributions with various ascertainment biases.
We have developed a software that applies ascertainment bias on simulated DNA sequences and calculates F(ST) on them, so they can be used to generate neutral distributions that are appropriate to test whether the genetic differentiation of a particular gene between populations is compatible with neutral evolution, or, on the contrary, suggests local adaptation by natural selection.


BACKGROUND
FABSIM is available from http://www.snpator.com/public/downloads/aRamirez/FABSIM/.
IBE, Institute of Evolutionary Biology (UPF-CSIC), CEXS-UPF-PRBB. Doctor Aiguader, 88. 08003 Barcelona, Catalonia, Spain.
Anna
A
Ramírez-Soriano
Francesc
F
Calafell
D001483:Base Sequence; D015982:Bias; D005787:Gene Frequency; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012641:Selection, Genetic; D017422:Sequence Analysis, DNA / Q000379:methods; D012984:Software