Increased serum leptin and insulin concentrations in canine hypothyroidism.
Serum concentrations of leptin and insulin were compared between gender-matched hypothyroid (n=25) and healthy (n=25) client-owned dogs within comparable age and body condition score (BCS) ranges. Fasted blood samples were collected from each dog and analysed for glucose, cholesterol, triglyceride, leptin and insulin concentrations. Leptin and insulin concentrations were significantly higher in the hypothyroid compared to normal dogs (P=0.006 and P=0.001, respectively) following adjustment for potential confounders. A nearly significant (P=0.051) interaction with BCS was found in the association between hypothyroidism and leptin. Leptin concentrations were significantly higher in hypothyroid dogs compared to normal dogs, in separate analyses for BCS 6 (P=0.036) and 7 (P=0.049). There was no significant difference in glucose concentration between the hypothyroid and normal groups (P=0.84) following adjustment for BCS. This study showed that canine hypothyroidism is associated with increased serum leptin and insulin concentrations, neither of which may be attributed to obesity alone.
Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel. Electronic address: mmtovi@gmail.com.
Michal
M
Mazaki-Tovi
The Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel.
Yonatan
Y
Feuermann
Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel.
Gilad
G
Segev
Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel.
Eyal
E
Klement
Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel.
Einat
E
Yas-Natan
The American Medical Laboratories, Herzliya, Israel.
Amnon
A
Farkas
Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel.
Amir
A
Kol
The Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel.
Avi
A
Shamay
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001824:Body Constitution; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D005260:Female; D007037:Hypothyroidism / Q000097:blood / Q000150:complications / Q000662:veterinary*; D007328:Insulin / Q000097:blood*; D020738:Leptin / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood / Q000209:etiology / Q000662:veterinary*; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D007328:Insulin; D020738:Leptin; D014280:Triglycerides; D002784:Cholesterol