Effect of silimarin, succinic acid, and their combination on bioenergetics of the brain in experimental encephalopathy.
In rats with experimental encephalopathy caused by intoxication with 4-pentenoic acid inhibiting beta-oxidation of medium- and long-chain fatty acids, hepatoprotector silimarin inhibited LPO, prevented deenergization and maintained high respiratory activity of brain mitochondria, and increased the rate and coupling of oxidation and phosphorylation. Succinic acid improved oxidation of substrates in motochondria and promoted activation of succinate-dependent ATP generation. Silimarin and succinic acid used together produced a synergistic protective effect on brain mitochondria surpassing the protective effects of individual preparations and prevented LPO activation.
Laboratory of Molecular Pharmacology, Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
V A
VA
Khazanov
A I
AI
Vengerovsky
D000818:Animals; D001927:Brain Diseases / Q000139:chemically induced / Q000378:metabolism*; D004338:Drug Combinations; D004734:Energy Metabolism / Q000187:drug effects; D005227:Fatty Acids / Q000378:metabolism; D005229:Fatty Acids, Monounsaturated; D008297:Male; D010085:Oxidative Phosphorylation / Q000187:drug effects; D051381:Rats; D012838:Silymarin / Q000008:administration & dosage / Q000494:pharmacology*; D019802:Succinic Acid / Q000008:administration & dosage / Q000494:pharmacology*
D004338:Drug Combinations; D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D012838:Silymarin; D019802:Succinic Acid; C009785:4-pentenoic acid