The exploding field of the HCV polymerase non-nucleoside inhibitors: summary of a first generation compounds.
The hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) is strictly essential for viral replication and it has been used as viral target for anti-HCV drug development. All small molecules which have been identified to be selective non-nucleoside inhibitors (NNI) of the HCV RdRp to date are reported.
Tramontano
Enzo
E
Department of Sciences and Biomedical Technologies, University of Cagliari, Monserrato (Cagliari), Italy. tramon@unica.it
D000495:Allosteric Site; D001665:Binding Sites; D020134:Catalytic Domain; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D016174:Hepacivirus / Q000201:enzymology*; D006526:Hepatitis C / Q000188:drug therapy*; D006801:Humans; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D008968:Molecular Conformation; D012324:RNA-Dependent RNA Polymerase / Q000037:antagonists & inhibitors* / Q000737:chemistry; D014779:Virus Replication
D012324:RNA-Dependent RNA Polymerase