Genetic association between -93A/G polymorphism in the Fyn kinase gene and alcohol dependence in Spanish men.
BACKGROUND
Fyn tyrosine kinase is a member of the Scr family that phosphorylates the NR2A and NR2B subunits of the NMDA receptors reducing the inhibitory effects of ethanol and therefore may regulate the individual sensitivity to ethanol.


OBJECTIVE
To investigate whether there is any relationship between the polymorphism at position -93 of the Fyn kinase gene and the susceptibility to develop alcoholism.


METHODS
We studied the distribution of genotypes and alleles of the polymorphism -93A/G (137346 T/C) in the 5' UTR region of the fyn gene in 207 male heavy drinkers (119 with alcohol dependence and 88 with alcohol abuse) and 100 control subjects from Castilla y León (Spain).


RESULTS
The frequency of G allele carriers was higher in alcohol dependents than in alcohol abusers (47.9% vs 30.6%; p=0.015; OR=2.077; 95% CI 1.165-3.704).


CONCLUSIONS
Our results show that the -93G allele of Fyn kinase gene is associated with higher risk to develop alcohol dependence in Spanish men.
Unidad de Medicina Molecular, Departamento de Medicina, Universidad de Salamanca, Avda. de Alfonso X el Sabio s/n, 37007 Salamanca, Spain.
Isabel J
IJ
Pastor
F Javier
FJ
Laso
Sandra
S
Inés
Miguel
M
Marcos
Rogelio
R
González-Sarmiento
D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000235:genetics* / Q000378:metabolism; D000483:Alleles; D002874:Chromosome Mapping; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D051076:Proto-Oncogene Proteins c-fyn / Q000235:genetics* / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics / Q000378:metabolism; D013030:Spain / Q000208:ethnology; D044465:White People / Q000235:genetics*
D016194:Receptors, N-Methyl-D-Aspartate; D051076:Proto-Oncogene Proteins c-fyn