Three-class-resistant human immunodeficiency virus type 1 variant in a drug-naive heterosexual couple.
Combination antiretroviral treatment was initiated in a heterosexual couple newly diagnosed with human immunodeficiency virus type 1 infection. Multiple genotypic drug resistance testing following early rebound of viral load revealed that the same three-class-resistant human immunodeficiency virus type 1 strain had been present in both patients since before initiation of treatment.
Razzolini
Francesca
F
Section of Microbiology, Department of Molecular Biology, University of Siena, Viale Bracci 1, I-53100 Siena, Italy. zazzi@unisi.it
Saladini
Francesco
F
Malincarne
Lisa
L
Vicenti
Ilaria
I
Palladino
Nicola
N
Romano
Laura
L
Francisci
Daniela
D
Zazzi
Maurizio
M
D019380:Anti-HIV Agents / Q000627:therapeutic use*; D024882:Drug Resistance, Viral; D005191:Family Characteristics; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology*; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification*; D020010:Heterosexuality; D006801:Humans; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000235:genetics*; D019562:Viral Load
D019380:Anti-HIV Agents; D012367:RNA, Viral