Primary uterine rhabdomyosarcoma in a patient with a history of breast cancer and gastrointestinal stromal tumor.
We describe a unique case of a 67-year-old patient with primary uterine rhabdomyosarcoma with a history of breast cancer and gastrointestinal stromal tumor of the stomach. Uterine rhabdomyosarcoma was diagnosed in our patient during adjuvant treatment of breast cancer with anastrozole. To the best of our knowledge, the development of primary uterine rhabdomyosarcoma has never been described in patients treated with anastrozole. Due to the suggested causative role of tamoxifen in the development of uterine sarcomas, it is interesting to analyze whether the new drug, anastrozole, exerts any pathogenic effect on the development of uterine sarocomas.
Department of Gynecological Oncology, Medical University of Lodz, Lodz, Poland.
Leszek
L
Gottwald
Ewa
E
Gora
Jerzy
J
Korczynski
Janusz H
JH
Piekarski
Zbigniew
Z
Morawiec
Dorota
D
Jesionek-Kupnicka
Piotr
P
Sowa
Aleksandra
A
Cialkowska-Rysz
Andrzej
A
Bienkiewicz
D000368:Aged; D000077384:Anastrozole; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy / Q000473:pathology; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000473:pathology; D006801:Humans; D016609:Neoplasms, Second Primary / Q000473:pathology*; D009570:Nitriles / Q000627:therapeutic use; D018233:Rhabdomyosarcoma, Embryonal / Q000473:pathology*; D013270:Stomach / Q000473:pathology; D014230:Triazoles / Q000627:therapeutic use; D014594:Uterine Neoplasms / Q000473:pathology*; D014599:Uterus / Q000473:pathology*
D009570:Nitriles; D014230:Triazoles; D000077384:Anastrozole