Susceptibility to Guillain-Barré syndrome is not associated with CD1A and CD1E gene polymorphisms.
Immune responses to microbial glycolipids that cross-react to neural epitopes may trigger the Guillain-Barré syndrome (GBS). CD1 molecules are involved in antigen presentation of glycolipids and variation in CD1 genes was recently reported to confer susceptibility to develop GBS. This hypothesis was tested by comparing single nucleotide polymorphisms (SNPs) of CD1A and CD1E in 312 well defined GBS patients and 212 healthy controls. SNPs in CD1A and CD1E were not associated with GBS susceptibility, specific clinical subgroups, anti-ganglioside antibodies, antecedent infections and prognosis. Based on this study, CD1 polymorphisms are not a susceptibility or disease modifying factor in GBS.
Department of Neurology, Erasmus MC, 's-Gravendijkwal 230, 3015CE, Rotterdam, The Netherlands.
Mark L
ML
Kuijf
Karin
K
Geleijns
Noureddine
N
Ennaji
Wouter
W
van Rijs
Pieter A
PA
van Doorn
Bart C
BC
Jacobs
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018949:Antigens, CD1 / Q000235:genetics*; D002648:Child; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D020275:Guillain-Barre Syndrome / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018709:Statistics, Nonparametric; D055815:Young Adult
D018949:Antigens, CD1; C419393:CD1a antigen; C417738:CD1e antigen