Interaction of kendomycin and semi-synthetic analogues with the anti-apoptotic protein Bcl-xl.
The cytotoxic macrolide kendomycin was identified as a ligand of Bcl-xl, an anti-apoptotic member of the Bcl-2 protein family. Hydrolysis-stable and protonable semi-synthetic analogues have been obtained that retain cytotoxicity and Bcl-xl binding.
MerLion Pharmaceuticals Pte Ltd, Medicinal Chemistry, Singapore Science Park II, Singapore 117528, Singapore.
Christian O
CO
Janssen
Stephanie
S
Lim
Ee Peng
EP
Lo
Kah Fei
KF
Wan
Victor C
VC
Yu
May Ann
MA
Lee
Siew Bee
SB
Ng
Martin J
MJ
Everett
Antony D
AD
Buss
David P
DP
Lane
Rustum S
RS
Boyce
D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D006801:Humans; D017828:Rifabutin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D051020:bcl-X Protein / Q000737:chemistry*
D051020:bcl-X Protein; C485395:kendomycin; D017828:Rifabutin