[A new cycloartane triterpene saponin from rhizome of Actaea asiatica].
OBJECTIVE
To isolate and elucidate the chemical constituents with the cytotoxicity activity from the rhizome of Actaea asiatica.


METHODS
The chemical constituents were isolated by repeated column chromatography (Toyopearl HW40C and preparative HPLC) and the structure of compound 1 was elucidated by spectral data analysis.


RESULTS
A cycloartane triterpene saponin com- pound was isolated and identified to be (23R)-16beta, 23: 23alpha, 26: 24alpha: 25-triepoxy-9, 19-cyclolanost-7-en-3beta-O-beta-D-xylopyranoside.


CONCLUSIONS
Compound 1 was a new compound and named (23R)-26-deoxycimicifugoside. The IC50 values of compound 1 for cell growth inhibition of Hela and L929 cell lines were 72.24 and 55.97 mg x L(-1), respectively.
School of Pharmaceutical Sciences, Tianjin Medical University, Tianjin 300070, China.
Bin
B
Lu
Yun-Shuang
YS
Fan
Hong-Quan
HQ
Duan
D031842:Actaea / Q000737:chemistry*; D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D051379:Mice; D018514:Plant Structures / Q000737:chemistry*; D012503:Saponins / Q000302:isolation & purification* / Q000494:pharmacology*
C540475:(23R)-26-deoxycimicifugoside; D012503:Saponins