Interaction of DNA with a novel photoactive platinum diimine complex.
Interaction of DNA with a novel photoactive platinum diimine compound has been studied by electronic absorption spectra, fluorescence spectra and viscosity measurements. The red light-induced DNA cleavage activity of the platinum compound has also been studied by agarose gel electrophoresis. The results suggest that the platinum compound may interact with DNA by intercalation mode. When irradiated with red light, the platinum compound can generate singlet oxygen, resulting in cleavage of DNA.
Institute of Molecular Science, Chemical Biology and Molecular Engineering Laboratory of Education Ministry, Shanxi University, Taiyuan, Shanxi, 030006, China. zgzhang@sxu.edu.cn
Zhigang
Z
Zhang
Xindian
X
Dong
D000818:Animals; D002417:Cattle; D004247:DNA / Q000737:chemistry; D007097:Imines / Q000138:chemical synthesis* / Q000737:chemistry*; D007364:Intercalating Agents / Q000494:pharmacology; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009690:Nucleic Acid Conformation / Q000187:drug effects; D010100:Oxygen / Q000737:chemistry; D010777:Photochemistry / Q000379:methods; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000737:chemistry; D010984:Platinum / Q000737:chemistry; D013050:Spectrometry, Fluorescence / Q000379:methods; D014783:Viscosity
D007097:Imines; D007364:Intercalating Agents; D017319:Photosensitizing Agents; D010984:Platinum; D004247:DNA; D010100:Oxygen