Inhibitor of apoptosis proteins in eukaryotic evolution and development: a model of thematic conservation.
The past decade and a half has witnessed the discovery of a large, evolutionarily conserved family of cellular genes bearing homology to the prototype baculovirus Inhibitor of Apoptosis (IAP). The logical decision in the field to also refer to these cellular proteins as IAPs fails to do justice to this versatile group of factors that play a wide range of roles in eukaryotic development and homeostasis which include, but are not limited to, the regulation of programmed cell death. Here we describe the shared functional characteristics of several well-characterized IAPs whose defining motifs place them more in the category of multifunctional modular protein interaction domains.
O'Riordan
Mary X D
MX
Department of Microbiology and Immunology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Bauler
Laura D
LD
Scott
Fiona L
FL
Duckett
Colin S
CS
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000502:physiology*; D020169:Caspases / Q000378:metabolism; D019143:Evolution, Molecular; D051034:Inhibitor of Apoptosis Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D008969:Molecular Sequence Data; D011485:Protein Binding / Q000235:genetics; D017434:Protein Structure, Tertiary / Q000235:genetics; D017386:Sequence Homology, Amino Acid
D051034:Inhibitor of Apoptosis Proteins; D020169:Caspases