Vaspin serum concentrations in patients with carotid stenosis.
Obesity is associated with accelerated atherosclerosis. Adipokines may directly influence vessel wall homeostasis by influencing the function of endothelial cells, arterial smooth muscle cells, and modulating inflammation. Recently, visceral adipose tissue-derived serpin (vaspin) was identified as a novel adipokine related to obesity and its metabolic consequences. However, the regulation of vaspin serum concentrations in human atherosclerosis is unknown. We therefore assessed vaspin serum concentrations in 107 consecutive patients with carotid stenosis undergoing carotid endarterectomy (CEA) in relation to severity of atherosclerosis, measures of obesity and circulating markers of obesity and atherosclerosis. Vaspin serum concentrations were significantly lower in patients with carotid stenosis who experienced an ischemic event within 3 months before surgery compared to asymptomatic patients. However, circulating vaspin was not associated with measures of atherosclerosis severity as maximum percentage stenosis. Vaspin serum concentrations were indistinguishable before and after CEA. We found a significant correlation between vaspin and leptin serum concentrations supporting previous results that vaspin closely reflects body fat mass. In conclusion, our data show that low vaspin serum concentrations correlate with recently experienced ischemic events in patients with carotid stenosis despite the lack of an association between circulating vaspin and parameters of atherosclerosis severity.
Center of Surgery, Department of Visceral, Transplantation, Thoracic, and Vascular Surgery, Medical Faculty, University of Leipzig, Leipzig, Germany. ausg@medizin.uni-leipzig.de
Gabriela
G
Aust
Olaf
O
Richter
Silvio
S
Rohm
Christiane
C
Kerner
Johann
J
Hauss
Nora
N
Klöting
Karen
K
Ruschke
Peter
P
Kovacs
Byung-Soo
BS
Youn
Matthias
M
Blüher
D000368:Aged; D015901:Angiography, Digital Subtraction; D015415:Biomarkers / Q000097:blood; D002545:Brain Ischemia / Q000097:blood / Q000209:etiology* / Q000601:surgery; D016893:Carotid Stenosis / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery; D016894:Endarterectomy, Carotid; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood; D016014:Linear Models; D008297:Male; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood* / Q000150:complications; D011237:Predictive Value of Tests; D018570:Risk Assessment; D012307:Risk Factors; D015843:Serpins / Q000097:blood*; D012720:Severity of Illness Index; D016896:Treatment Outcome
D015415:Biomarkers; D020738:Leptin; C507339:SERPINA12 protein, human; D015843:Serpins