Alpha-Glutathione S-transferase and serum aminotransferases in schistosomiasis mansoni patients with or without hepatitis C virus.
The present study evaluated alpha-Glutathione-S-transferase as a biochemical marker for hepatocellular damage in schistosomiasis mansoni patients, with or without chronic hepatitis C (HCV) patients as compared to controls. Alpha GST, ALT and AST were assayed in sera of GI: 20 schistosomiasis mansoni patients with HCV, GII: 16 schistosomiasis mansoni patients without HCV, GIII: 19 pure HCV patients and GIV: 20 normal controls. The results showed that alpha-Glutathione-S-transferase was less sensitive and less specific but more accurate than ALT & AST as a liver affection marker in HCV patients.
Department of Internal Medicine, Faculty of Medicine, University of Al-Azhar, Cairo, Egypt.
Amal Mokhtar
AM
Ahmed
Ahmed H
AH
Abdel-Tawab
Ayman T A
AT
Morsy
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D004796:Clinical Enzyme Tests; D005260:Female; D005982:Glutathione Transferase / Q000097:blood*; D006526:Hepatitis C / Q000201:enzymology*; D006801:Humans; D008099:Liver / Q000201:enzymology* / Q000469:parasitology / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D012555:Schistosomiasis mansoni / Q000201:enzymology*; D000637:Transaminases / Q000097:blood*
D015415:Biomarkers; D005982:Glutathione Transferase; D000637:Transaminases; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase