Enyne cross-metathesis with strained, geminally-substituted alkenes: direct access to highly substituted 1,3-dienes.
Angle strain in methylene cyclobutane was used to drive a cross-enyne metathesis with 1-alkynes, giving 1,1,3-trisubstituted 1,3-dienes in good isolated yields. An extensive survey of Grubbs' second-generation catalysts led to an optimized reaction conducted at 0 degrees C.
Clark
Daniel A
DA
Department of Chemistry, University at Buffalo, The State University of New York, Amherst, New York 14260, USA.
Basile
Brenda S
BS
Karnofel
William S
WS
Diver
Steven T
ST