The influence of DeltaFosB in the nucleus accumbens on natural reward-related behavior.
The transcription factor deltaFosB (DeltaFosB), induced in nucleus accumbens (NAc) by chronic exposure to drugs of abuse, has been shown to mediate sensitized responses to these drugs. However, less is known about a role for DeltaFosB in regulating responses to natural rewards. Here, we demonstrate that two powerful natural reward behaviors, sucrose drinking and sexual behavior, increase levels of DeltaFosB in the NAc. We then use viral-mediated gene transfer to study how such DeltaFosB induction influences behavioral responses to these natural rewards. We demonstrate that overexpression of DeltaFosB in the NAc increases sucrose intake and promotes aspects of sexual behavior. In addition, we show that animals with previous sexual experience, which exhibit increased DeltaFosB levels, also show an increase in sucrose consumption. This work suggests that DeltaFosB is not only induced in the NAc by drugs of abuse, but also by natural rewarding stimuli. Additionally, our findings show that chronic exposure to stimuli that induce DeltaFosB in the NAc can increase consumption of other natural rewards.
Wallace
Deanna L
DL
Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9070, USA.
Vialou
Vincent
V
Rios
Loretta
L
Carle-Florence
Tiffany L
TL
Chakravarty
Sumana
S
Kumar
Arvind
A
Graham
Danielle L
DL
Green
Thomas A
TA
Kirk
Anne
A
Iñiguez
Sergio D
SD
Perrotti
Linda I
LI
Barrot
Michel
M
DiLeone
Ralph J
RJ
Nestler
Eric J
EJ
Bolaños-Guzmán
Carlos A
CA
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D004326:Drinking / Q000187:drug effects / Q000502:physiology; D004334:Drug Administration Schedule; D005260:Female; D008297:Male; D009714:Nucleus Accumbens / Q000187:drug effects / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012201:Reward; D012726:Sexual Behavior, Animal / Q000502:physiology; D012996:Solutions; D013395:Sucrose / Q000008:administration & dosage / Q000494:pharmacology; D015854:Up-Regulation
C483820:Fosb protein, rat; D016760:Proto-Oncogene Proteins c-fos; D012996:Solutions; D013395:Sucrose