Functional serotonin 1A receptor variant influences treatment response to atypical antipsychotics in schizophrenia.
The serotonin (5-HT) 1A receptor has been found to be dysregulated in prefrontal cortex and other brain regions in schizophrenia, and 5-HT1A receptor levels in the amygdala have been related to negative schizophrenia symptoms. We have assessed the impact of the functional C-1019G variant of the 5-HT1A receptor on the response to risperidone or haloperidol in a prospective, randomized, double-blind study. Patients were treated for 4 weeks and negative symptoms assessed weekly. The variant influenced the response to risperidone: improvement of negative symptoms by 4.38 points for carriers of the C allele, compared with the GG genotype (1.22 points, P=0.046). In a second independent study of 130 schizophrenia patients treated with atypical antipsychotics, this effect was confirmed (P=0.003). The functional variant of the 5-HT1A receptor thus influences the response of schizophrenia patients to atypical antipsychotics and may be useful in the future to predict the pharmacogenetics of negative symptoms.
Mössner
Rainald
R
Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany. rainald.moessner@ukb.uni-bonn.de
Schuhmacher
Anna
A
Kühn
Kai-Uwe
KU
Cvetanovska
Gabriela
G
Rujescu
Dan
D
Zill
Peter
P
Quednow
Boris B
BB
Rietschel
Marcella
M
Wölwer
Wolfgang
W
Gaebel
Wolfgang
W
Wagner
Michael
M
Maier
Wolfgang
W
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005838:Genotype; D006220:Haloperidol / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics*; D018967:Risperidone / Q000627:therapeutic use; D012559:Schizophrenia / Q000188:drug therapy* / Q000235:genetics*; D055815:Young Adult
D014150:Antipsychotic Agents; D044282:Receptor, Serotonin, 5-HT1A; D006220:Haloperidol; D018967:Risperidone