[Effects of Shengqing Capsule on biochemical parameters in mice with cholesterol gallstone].
OBJECTIVE
To observe the effects of Shengqing Capsule (SQC), a compound of traditional Chinese herbal medicine, on biochemical parameters in C57BL/6J mice with cholesterol gallstone.


METHODS
Thirty-eight C57BL/6J mice were randomly divided into normal control group (n=10), untreated group (n=15) and SQC group (n=13). Cholesterol gallstone was induced in mice of the latter two groups by feeding high cholesterol diet. Mice in the SQC group were intragastricly administered SQC 0.22 g/(kg.d). After 8-week treatment, animals were sacrificed and sampled to calculate the incidences of stone formation. The contents of serum cholesterols and Ca(2+), and the malonaldehyde (MDA) content and superoxide dismutase (SOD) activity in liver tissues were detected.


RESULTS
The incidences of stone formation were 73.33% in untreated group, 0% in normal control group, and 23.08% in the SQC group. And the INCIDENCE in untreated group was significantly higher than those in the normal control group and the SQC group (P<0.01). Contents of serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) in the SQC group were lower than that in the untreated group (P<0.01), and high-density lipoprotein cholesterol (HDL-C) in the SQC group was higher than that in the untreated group (P<0.01). SQC could increase the SOD activity and decrease the MDA content in liver tissues, showing significant differences as compared with those in the untreated group (P<0.05).


CONCLUSIONS
SQC can decrease the incidence of stone formation and improve the biochemical parameters, which may be one of the mechanisms in the treatment and prevention of cholesterol gallstone disease.
Department of Hepatobiliary Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Xue-Lin
XL
Zhang
Xiao-Qiang
XQ
Liang
Hong-Gang
HG
Gu
En-Wei
EW
Ma
Tian-Bi
TB
Lin
Xun
X
Sun
Jing-Zhe
JZ
Zhang
D000818:Animals; D002214:Capsules; D002784:Cholesterol / Q000097:blood*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D042882:Gallstones / Q000737:chemistry / Q000378:metabolism* / Q000517:prevention & control*; D008074:Lipoproteins / Q000097:blood; D051379:Mice; D008810:Mice, Inbred C57BL; D008517:Phytotherapy; D011897:Random Allocation; D013482:Superoxide Dismutase / Q000378:metabolism*
D002214:Capsules; D004365:Drugs, Chinese Herbal; D008074:Lipoproteins; C527180:shengqing; D002784:Cholesterol; D013482:Superoxide Dismutase