CD5 negative, Cyclin D1-positive diffuse large B-cell lymphoma (DLBCL) presenting as ruptured spleen.
We present a case of diffuse large B-cell lymphoma CD5 negative, Cyclin D1 positive presenting as ruptured spleen in a 63-year-old man requiring emergent splenectomy. Tumor cells showed marked pleomorphism, anaplasia, and increased mitotic figures with positive Cyclin D1, BCL6, MUM1, P53, and a high MIB1 proliferative fraction. The patient received multiple therapies and ultimately died. This case raises the differential diagnoses of pleomorphic mantle cell lymphoma and other aggressive lymphomas with pleomorphic, anaplastic, and Reed-Sternberg-like cells.
Teruya-Feldstein
Julie
J
Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. feldstej@mskcc.org
Gopalan
Anuradha
A
Moskowitz
Craig H
CH
D000971:Antineoplastic Combined Chemotherapy Protocols; D018956:CD5 Antigens / Q000032:analysis*; D019938:Cyclin D1 / Q000032:analysis*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D012422:Rupture, Spontaneous / Q000175:diagnosis* / Q000188:drug therapy; D013161:Splenic Rupture / Q000175:diagnosis*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis; D044767:Ubiquitin-Protein Ligases / Q000032:analysis
D018956:CD5 Antigens; D016159:Tumor Suppressor Protein p53; D019938:Cyclin D1; C513496:MIB1 ligase, human; D044767:Ubiquitin-Protein Ligases