Transferrin induces interleukin-18 expression in chronic myeloid leukemia cell line, K-562.
Transferrin is an iron carrier protein involved in iron uptake and the regulation of cell growth. Although highly proliferative cells express transferrin and its receptor, little is known about the role of transferrin in the cellular response to cytokine production. The non-iron-bound form of transferrin (apo-transferrin) was administered to human chronic myeloid leukemia cell line, K-562 cells to assess whether it could induce interleukin-18 (IL-18). Apo-transferrin enhanced IL-18 mRNA and protein and, moreover, IL-18 secretion was increased by treatment with apo-transferrin. In conclusion, apo-transferrin regulates IL-18 expression and we suggest that it is involved in cytokine production.
Park
Sunyoung
S
Department of Life Science, Sookmyung Women's University, Seoul, Republic of Korea.
Kim
Tae Sung
TS
Kim
Cherlhyun
C
Kim
Seonghan
S
Bang
Sa Ik
SI
Park
Hyunjeong
H
Cho
Dae-Ho
DH
D001059:Apoproteins; D016207:Cytokines / Q000096:biosynthesis; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D006801:Humans; D020382:Interleukin-18 / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism; D020014:K562 Cells; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000276:immunology*; D012333:RNA, Messenger / Q000032:analysis / Q000187:drug effects; D014168:Transferrin / Q000494:pharmacology*
D001059:Apoproteins; D016207:Cytokines; D020382:Interleukin-18; D012333:RNA, Messenger; D014168:Transferrin