Porphyria cutanea tarda as a complication of therapy for chronic hepatitis C.
There is a strong association between porphyria cutanea tarda (PCT) and chronic viral hepatitis C. Therapy for chronic viral hepatitis C may improve PCT. However, there are only a few reports of the de novo development of PCT during therapy for chronic viral hepatitis C. We describe the development of PCT in a 56-year-old patient with chronic viral hepatitis C after 12 wk of peginterferon/ribavirin therapy. In addition, the patient was homozygous for the H63D hereditary hemochromatosis gene (HFE) mutation. The association of PCT with chronic viral hepatitis C and the possible role of hepatic iron overload and ribavirin-induced hemolytic anemia in the development of PCT during therapy for chronic viral hepatitis C are discussed.
Ann Arbor VA Healthcare System, Ann Arbor, Michigan 48105, USA. rmoseley@med.umich.edu
James
J
Azim
Heather
H
McCurdy
Richard-H
RH
Moseley
D000743:Anemia, Hemolytic / Q000139:chemically induced; D000998:Antiviral Agents / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D006432:Hemochromatosis / Q000235:genetics; D000071020:Hemochromatosis Protein; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D015395:Histocompatibility Antigens Class I / Q000235:genetics; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects*; D019190:Iron Overload / Q000150:complications; D008297:Male; D008565:Membrane Proteins / Q000235:genetics; D008875:Middle Aged; D009154:Mutation; D018962:Phlebotomy; D011092:Polyethylene Glycols; D017119:Porphyria Cutanea Tarda / Q000139:chemically induced* / Q000235:genetics / Q000628:therapy; D011994:Recombinant Proteins; D012254:Ribavirin / Q000009:adverse effects*
D000998:Antiviral Agents; C103673:HFE protein, human; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D008565:Membrane Proteins; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; D012254:Ribavirin; C417083:peginterferon alfa-2b