Accuracy and sensitivity of finite element model-based deformable registration of the prostate.
OBJECTIVE
Evaluate the accuracy and the sensitivity to contour variation and model size of a finite element model-based deformable registration algorithm for the prostate.


METHODS
Two magnetic resonance images (MRIs) were obtained for 21 prostate patients with three implanted markers. A single observer contoured the prostate and markers and performed blinded recontouring of the first MRI. A biomechanical-model based deformable registration algorithm, MORFEUS, was applied to each dataset pair, deforming the second image (B) to the first image (A). The residual error was calculated by comparing the center of mass (COM) of the markers with the predicted COM. Sensitivity to contour variation was calculated by deforming B to the repeat contour of A (A2). The sensitivity to the model size was calculated by reducing the number of nodes (B', A', A2') and repeating the analysis.


RESULTS
The average residual error of the registration for B to A and B to A2 was 0.22 cm (SD: 0.08 cm) and 0.24 cm (SD: 0.09 cm), respectively. The average residual error of the registration of B' to A' and B' to A2' was 0.22 cm (SD: 0.10 cm) and 0.25 cm (SD: 0.10 cm), respectively. The average time to run MORFEUS on the standard and reduced model was 3606 s (SD: 7788 s) and 56 s (SD: 16 s), respectively.


CONCLUSIONS
The accuracy of the algorithm, equal to the image voxel size, is not affected by intraobserver contour variability or model size. Reducing the model size significantly increases algorithm efficiency.
Brock
Kristy K
KK
Radiation Medicine Program, Princess Margaret Hospital, University Health Network, and the University of Toronto, Toronto, Ontario M5G 2M9, Canada. kristy.brock@rmp.uhn.on.ca
Nichol
Alan M
AM
Ménard
Cynthia
C
Moseley
Joanne L
JL
Warde
Padraig R
PR
Catton
Charles N
CN
Jaffray
David A
DA
D000465:Algorithms; D020342:Finite Element Analysis; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D011471:Prostatic Neoplasms / Q000473:pathology*