[Effects of Sisheng Decoction on spontaneous activity and serum concentration of malondialdehyde in mice with yin deficiency syndrome].
OBJECTIVE
To assess the therapeutic effects of Sisheng Decoction, a compound traditional Chinese herbal medicine, on a mouse model of yin deficiency syndrome induced by thyroid hormone, and to make the preliminary study on its mechanisms.


METHODS
Simultaneous modeling and treatment were carried out. Sixty mice were randomly divided into six groups: normal group, yin deficiency model group, low-, medium- and high-dose Sisheng Decoction group and Shengmai oral liquid group. Normal group and yin deficiency model group were administered with double distilled water. Spontaneous activity and serum concentration of malondialdehyde in different groups were detected.


RESULTS
The symptoms of yin deficiency syndrome such as xerostomia, dysphoria and fervescence were improved in the Sisheng Decoction groups. Compared with the yin deficiency model group, the spontaneous activity was increased and the serum concentration of malondialdehyde was decreased in the Sisheng Decoction groups (P<0.05). There was no significant difference between the Sisheng Decoction groups and the Shengmai oral liquid group (P<0.05).


CONCLUSIONS
Medium- or high-dose Sisheng Decoction is effective for nourishing yin, clearing heat, engendering liquid and allaying thirst. The above effects of Sisheng Decoction may be realised by improving the spontaneous activity and resisting oxidative damage.
Zhang
Su-Fang
SF
Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
Chen
Zhe
Z
Li
Bai
B
Chen
Hong-Yun
HY
Ling
Chang-Quan
CQ
Wen
Xin-Yu
XY
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D008517:Phytotherapy; D013963:Thyroid Hormones; D016710:Yin Deficiency / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D013963:Thyroid Hormones; D008315:Malondialdehyde