Activated protein C levels in obesity and weight loss influence.
Obesity is associated with a high risk of cardiovascular events. Several haemostatic disturbances which could contribute to this increased risk have been described in obesity; nevertheless, the state of coagulation inhibitors has been scarcely studied in these patients. The aim of the present study was to compare activated protein C levels in obese patients and in a control group, and to evaluate the effect of weight loss. In 67 severe or morbid obese patients, an evaluation was performed at baseline and 3 months after diet. The same determinations were performed in 67 healthy volunteers with normal body weight. We also quantified the levels of protein C and prothrombin fragment 1+2. Obese patients showed significantly higher levels of activated protein C, protein C and fragment 1+2. No correlation was found between activated protein C and fragment 1+2 levels in obese patients. After three months of diet, a significant decrease in activated protein C and fragment 1+2 was observed. In conclusion, activated protein C levels are increased in obese patients, but only a minor fraction of this increase may be explained by the higher thrombin generation and C protein levels. Activated protein C levels decrease with weight loss, due in part to a thrombin generation reduction.
Solá
Eva
E
Endocrinology Service, Doctor Peset University Hospital, Valencia, Spain. eva.sola@uv.es
Navarro
Silvia
S
Medina
Pilar
P
Vayá
Amparo
A
Estellés
Amparo
A
Hernández-Mijares
Antonio
A
España
Francisco
F
D000328:Adult; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D010446:Peptide Fragments / Q000032:analysis; D011486:Protein C / Q000032:analysis* / Q000378:metabolism; D011516:Prothrombin / Q000032:analysis; D015431:Weight Loss
D010446:Peptide Fragments; D011486:Protein C; C045879:prothrombin fragment 1.2; D011516:Prothrombin