Phorbasins G-K: new cytotoxic diterpenes from a southern Australian marine sponge, Phorbas sp.
Fractionation of a cytotoxic extract obtained from a southern Australian marine sponge, Phorbas sp., yielded the known diterpenes phorbasins B-F () together with five new members of the phorbasin family, phorbasins G-K (). Structures were assigned to the new phorbasins based on detailed spectroscopic analysis. A preliminary structure activity relationship (SAR) evaluation based on the co-metabolites phorbasins B-K () revealed aspects of the phorbasin pharmacophore.
Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.
Hua
H
Zhang
Jodie M
JM
Major
Richard J
RJ
Lewis
Robert J
RJ
Capon
D000818:Animals; D001315:Australia; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003603:Cytotoxins / Q000737:chemistry* / Q000633:toxicity*; D004224:Diterpenes / Q000737:chemistry* / Q000633:toxicity*; D009682:Magnetic Resonance Spectroscopy; D011161:Porifera / Q000737:chemistry*
D003603:Cytotoxins; D004224:Diterpenes