Anti-inflammatory properties of a heparin-like glycosaminoglycan with reduced anti-coagulant activity isolated from a marine shrimp.
The anti-inflammatory properties of a heparin-like compound from the shrimp Litopenaeus vannamei are related. Besides reducing significantly (p<0.001) the influx of inflammatory cells to injury site in a model of acute inflammation, shrimp heparin-like compound was able to reduce the matrix metalloproteinase (MMPs) activity in the peritoneal lavage of inflamed animals. Moreover, this compound also reduced almost 90% the activity of MMP-9 secreted by human activated leukocytes. Negligible anti-coagulant activities in aPPT assay and a poor bleeding potential make this compound a better alternative than mammalian heparin as a possible anti-inflammatory drug.
Brito
Adriana S
AS
Departamento de Bioquímica, Universidade Federal do Rio Grande do Norte, UFRN, Campus Universitario, Natal, RN, Brazil.
Arimatéia
Dayse S
DS
Souza
Lucilla R
LR
Lima
Marcelo A
MA
Santos
Vanessa O
VO
Medeiros
Valquíria P
VP
Ferreira
Paula A
PA
Silva
Rodrigo A
RA
Ferreira
Carmen V
CV
Justo
Giselle Z
GZ
Leite
Edda L
EL
Andrade
Giulianna P V
GP
Oliveira
Fernanda W
FW
Nader
Helena B
HB
Chavante
Suely F
SF
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D000925:Anticoagulants / Q000737:chemistry / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D006025:Glycosaminoglycans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006470:Hemorrhage / Q000188:drug therapy; D006493:Heparin / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006497:Heparan Sulfate / Q000378:metabolism; D007249:Inflammation / Q000188:drug therapy*; D007962:Leukocytes / Q000187:drug effects / Q000201:enzymology; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D009504:Neutrophils / Q000187:drug effects; D033561:Penaeidae / Q000502:physiology*; D010529:Peritoneal Cavity / Q000502:physiology; D011817:Rabbits; D051381:Rats; D013552:Swine
D000893:Anti-Inflammatory Agents; D000925:Anticoagulants; D006025:Glycosaminoglycans; D006493:Heparin; D006497:Heparan Sulfate; D020780:Matrix Metalloproteinase 9