Inspiratory muscle training for cystic fibrosis.
BACKGROUND
Cystic fibrosis is the most common life-limiting genetic condition in Caucasians and the life-expectancy of those newly diagnosed is increasing. Inspiratory muscle training may be a way of improving the lung function and quality of life of people with cystic fibrosis. Hence there is a need to establish whether this intervention is beneficial.


OBJECTIVE
To determine the effect of inspiratory muscle training on health-related quality of life, pulmonary function and exercise tolerance.


METHODS
We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials register comprising of references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings.Date of most recent search: April 2008.


METHODS
Randomised or quasi-randomised clinical controlled trials comparing different inspiratory muscle training regimens with each other or a control in people with cystic fibrosis.


METHODS
Three review authors independently applied the inclusion and exclusion criteria to publications and assessed the quality of the included studies.


RESULTS
Seven studies were identified. Of these six studies with 140 participants met the review inclusion criteria. There was wide variation in the quality of the included studies. Data were not published in sufficient detail or with sufficiently similar outcome measures in these studies to perform meta-analyses.


CONCLUSIONS
We have not found any evidence to suggest that this treatment is either beneficial or not. We would advise that practitioners evaluate on a case-by-case basis whether or not to employ this therapy. We recommend that future studies make more use of health-related quality of life and exercise tolerance measures; and that there is an agreement upon a single standard measure of classifying the clinical status of the participants.
Houston
Brian W
BW
School of Health & Social Care, University of Teesside, Victoria Road, Middlesbrough, Cleveland, UK, TS1 3BA. brian.houston@tees.ac.uk
Mills
Nicola
N
Solis-Moya
Arturo
A
D001945:Breathing Exercises; D003550:Cystic Fibrosis / Q000628:therapy*; D006801:Humans; D001239:Inhalation / Q000502:physiology*; D016032:Randomized Controlled Trials as Topic; D012132:Respiratory Muscles / Q000502:physiology*