Structure elucidation and NMR assignments for two amide alkaloids from a Mangrove endophytic Fungus (No. ZZF-22).
The structure elucidations and complete (1)H and (13)C NMR assignments are reported for two new natural products: 3-benzylidene-8,8a-dihydroxy-2-methyl-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione(1) and 4-hydroxy-6-(hydroxy-phenyl-methyl)-N-(3-methyl-butyryl)-nicotinamide (2). Both of these secondary metabolites were isolated from the fermentation medium of a Mangrove endophytic fungus. High resolution electron impact mass spectrometry (HREIMS), FT-IR Spectroscopy and NMR experiments including gCOSY, gHMQC, gHMBC and NOE were used for determination of the structures and assignments of the amide alkaloids.
School of Chemistry and Chemical Engineering, Sun Yat-Sen (Zhongshan) University, Guangzhou, 510275, PR China.
Yiguang
Y
Chen
Changlun
C
Shao
Zhongjing
Z
Huang
Ying
Y
Zhang
Xiaoling
X
Cai
Zhigang
Z
She
Shining
S
Zhou
Yongcheng
Y
Lin
D000470:Alkaloids / Q000737:chemistry*; D000577:Amides / Q000737:chemistry; D001688:Biological Products / Q000737:chemistry; D002247:Carbon Isotopes; D005658:Fungi / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D019684:Magnoliopsida / Q000382:microbiology; D013058:Mass Spectrometry; D015394:Molecular Structure; D043982:Rhizophoraceae / Q000382:microbiology; D017550:Spectroscopy, Fourier Transform Infrared
D000470:Alkaloids; D000577:Amides; D001688:Biological Products; D002247:Carbon Isotopes