A child with human parvovirus B19 infection induced aplastic anemia and acute hepatitis: effectiveness of immunosuppressive therapy.
Human parvovirus B19 (HPV B19) infections are usually asymptomatic or benign and self-limiting. In immunocompromised patients and patients with chronic hemolytic anemia, it can lead to transient red cell aplasia. Few reports in the literature have implicated HPV B19 as the possible cause of acute hepatitis and severe aplastic anemia in immunocompetent patients. Here, the authors report a previously healthy 6-year-old girl with acute hepatitis and severe aplastic anemia associated with HPV B19 infection diagnosed by serology (ELISA). Other common causes of these manifestations were ruled out. The clinical manifestations subsequently improved significantly with the use of immunosuppressive therapy confirming an autoimmune mechanism.
Department of Child Health, Sultan Qaboos University, Al-Khoudh, Oman.
Raghad M
RM
Al-Abdwani
Faryal A
FA
Khamis
Abdullah
A
Balkhair
Mathew
M
Sacharia
Yasser A
YA
Wali
D000208:Acute Disease; D000741:Anemia, Aplastic / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D002648:Child; D016572:Cyclosporine / Q000627:therapeutic use; D005260:Female; D006525:Hepatitis, Viral, Human / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008775:Methylprednisolone / Q000627:therapeutic use; D010322:Parvoviridae Infections / Q000150:complications* / Q000188:drug therapy; D016732:Parvovirus B19, Human
D000893:Anti-Inflammatory Agents; D000961:Antilymphocyte Serum; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D008775:Methylprednisolone