Capturing protein tails by CAP-Gly domains.
Cytoskeleton-associated protein-glycine-rich (CAP-Gly) domains are protein-interaction modules implicated in important cellular processes and in hereditary human diseases. A prominent function of CAP-Gly domains is to bind to C-terminal EEY/F-COO(-) sequence motifs present in alpha-tubulin and in some microtubule-associated protein tails; however, CAP-Gly domains also interact with other structural elements including end-binding homology domains, zinc-finger motifs and proline-rich sequences. Recent findings unravelled the link between tubulin tyrosination and CAP-Gly-protein recruitment to microtubules. They further provided a molecular basis for understanding the role of CAP-Gly domains in controlling dynamic cellular processes including the tracking and regulation of microtubule ends. It is becoming increasingly clear that CAP-Gly domains are also involved in coordinating complex and diverse aspects of cell architecture and signalling.
Biomolecular Research, Structural Biology, Paul Scherrer Insititut, Villigen PSI, Switzerland. michel.steinmetz@psi.ch
Michel O
MO
Steinmetz
Anna
A
Akhmanova
D000595:Amino Acid Sequence; D000818:Animals; D017124:Conserved Sequence; D003598:Cytoskeletal Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000074749:Deubiquitinating Enzyme CYLD; D000072159:Dynactin Complex; D006801:Humans; D007011:Hypoparathyroidism / Q000235:genetics; D008607:Intellectual Disability / Q000235:genetics; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism; D008954:Models, Biological; D008958:Models, Molecular; D018832:Molecular Chaperones / Q000235:genetics; D008969:Molecular Sequence Data; D009134:Muscular Atrophy, Spinal / Q000235:genetics; D009154:Mutation; D009363:Neoplasm Proteins / Q000378:metabolism; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment; D013577:Syndrome; D025521:Tumor Suppressor Proteins / Q000235:genetics
D003598:Cytoskeletal Proteins; D000072159:Dynactin Complex; D008869:Microtubule-Associated Proteins; D018832:Molecular Chaperones; D009363:Neoplasm Proteins; C469270:TBCE protein, human; D025521:Tumor Suppressor Proteins; C109878:cytoplasmic linker protein 115; C076744:cytoplasmic linker protein 170; C409984:CYLD protein, human; D000074749:Deubiquitinating Enzyme CYLD