Therapeutic potential of stem cells in elderly patients with cardiovascular disease.
The success of treatment for acute myocardial infarction and chronic myocardial ischemia has improved general medical care in Europe, resulting in an increasing population of patients with chronic and congestive heart failure. By applying currently available therapeutic options the quality of life and lifespan of these patients have both increased. However, amongst patients -- predominantly the elderly -- who remain symptomatic despite intensive medical treatment, autologous bone marrow-derived mononuclear cells may trigger attempts to repopulate lost tissues directly as a novel therapeutic option. In this concised paper the current understanding of stem cell therapy and early clinical experiences are discussed and related to the application of stem cells in elderly patients with myocardial ischemia.
Brehm
M
M
Department of Cardiology, Pneumology and Vascular Medicine, Heinrich-Heine University, Düsseldorf, Germany. brehm@med.uni-duesseldorf.de
Stanske
B
B
Strauer
B E
BE
D000368:Aged; D049109:Cell Proliferation; D016922:Cellular Senescence / Q000502:physiology; D006801:Humans; D017202:Myocardial Ischemia / Q000473:pathology / Q000628:therapy*; D009206:Myocardium / Q000473:pathology; D012038:Regeneration / Q000502:physiology; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology*