[Effects of Shujing Ketong soft capsules on uterine activity of animals].
OBJECTIVE
To observe effects of Shujing Ketong soft capsules (SJKTSC) on activities of the uterine of the rat in vitro and in vivo.


METHODS
The isolated rat uterine were mounted in the improved Genell solution with a final content of 0. 96, 1.92, 3.84 microg x g(-1) of SJKTSC at 37 degrees C; and 9. 6, 19. 2, 38.4 mg x kg(-1) of SJKTSC and 2 g x kg(-1) of Tongjingbao granules were given to the rat through the duodenum respectively. Their effects on frequency, amplitude and activity of contraction of rat uterus in vitro and in vivo were investigated.


RESULTS
SJKTSC could significantly inhibit the frequency, amplitude and activity of contraction of the normal rat uterus in vitro and decrease the oxytocin-induced increase of contraction of the rat uterus in vitro; lowered the frequency, amplitude and activity of the oxytocin-induced contraction of the rat uterus in vivo and inhibit the oxytocin-induced the strengthening of contraction of the rat uterus in vivo.


CONCLUSIONS
Shujing Ketong soft capsules maybe used for treatment of dysmenorrhea induced by spasm of uterine smooth muscle.
Shanghai University of Traditional Chinese Medicine, Shanghai 210203, China.
Yan
Y
Xie
Zhen-yu
ZY
Xuan
Li
L
Yu
Jing
J
Guo
D000818:Animals; D002214:Capsules; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D004412:Dysmenorrhea / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D066298:In Vitro Techniques; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D010121:Oxytocin / Q000009:adverse effects; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014590:Uterine Contraction / Q000187:drug effects*; D014599:Uterus / Q000187:drug effects* / Q000502:physiology*
D002214:Capsules; D004365:Drugs, Chinese Herbal; C540582:shujing ketong; D010121:Oxytocin