Plasmonic intravascular photoacoustic imaging for detection of macrophages in atherosclerotic plaques.
To detect macrophages in atherosclerotic plaques, plasmonic gold nanoparticles are introduced as a contrast agent for intravascular photoacoustic imaging. The phantom and ex vivo tissue studies show that the individual spherical nanoparticles, resonant at 530 nm wavelength, produce a weak photoacoustic signal at 680 nm wavelength while photoacoustic signal from nanoparticles internalized by macrophages is very strong due to the plasmon resonance coupling effect. These results suggest that intravascular photoacoustic imaging can assess the macrophage-mediated aggregation of nanoparticles and therefore identify the presence and the location of nanoparticles associated with macrophage-rich atherosclerotic plaques.
Department of Biomedical Engineering, University of Texas at Austin, Austin, Texas 78712, USA.
Bo
B
Wang
Evgeniya
E
Yantsen
Timothy
T
Larson
Andrei B
AB
Karpiouk
Shriram
S
Sethuraman
Jimmy L
JL
Su
Konstantin
K
Sokolov
Stanislav Y
SY
Emelianov
D000162:Acoustics; D000818:Animals; D050197:Atherosclerosis / Q000175:diagnosis*; D001808:Blood Vessels / Q000378:metabolism / Q000473:pathology; D003287:Contrast Media / Q000378:metabolism; D006046:Gold / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism*; D053768:Metal Nanoparticles; D051379:Mice; D019047:Phantoms, Imaging; D020349:Surface Plasmon Resonance
D003287:Contrast Media; D006046:Gold