Directed hybridization of DNA derivatized nanoparticles into higher order structures.
Electric field directed hybridization was used to produce twenty layer nanostructures composed of DNA derivatized nanoparticles. Using an electronic microarray device, DNA nanoparticles could be directed and concentrated such that rapid and specific hybridization occurs only on the activated sites. Nanoparticle layers were formed within 30 s of activation and twenty layer structures completed in under an hour. Results demonstrate a unique combination of bottom-up and top-down techniques for nanofabrication.
Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, California 92093-0412, USA.
Dietrich A
DA
Dehlinger
Benjamin D
BD
Sullivan
Sadik
S
Esener
Michael J
MJ
Heller
D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000737:chemistry
D009841:Oligonucleotides; D004247:DNA