[Susceptibility of Staphylococcus aureus to new macrolide antibiotics].
A total of 73 isolates of Staphylococcus aureus (26 - MRSA, 47 - MSSA) were tested for their susceptibility to macrolide antibiotics and new derivatives (azalide - azythromycin and ketolide -telithromycin). We observed a high - level resistance of MRSA isolates to all tested antibiotics. Over 96% of isolates were resistant to macrolides and azalides and 92,3% to ketolides. Majority of MSSA isolates (93.6%) demonstrated a high-level susceptibility to telithromycin. Mechanisms of resistance to macrolide antibiotics (34 - MLSB and 1 - MSB) were found among 47,9% Staphylococcus aureus isolates. All of MSSA (100%) and 40% MRSA isolates with induction phenotype of resistance (MLSB(I)) were sensitive to telithromycin. Isolates with constitutive phenotype of resistance (MLSB(K)) were resistant to all of the tested antibiotics.
Zakład Diagnostyki Mikrobiologicznej Akademii Medycznej w Białymstoku. sachpt@amb.edu.pl
Paweł
P
Sacha
Piotr
P
Wieczorek
Piotr
P
Jakoniuk
D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D006801:Humans; D048628:Ketolides / Q000494:pharmacology*; D018942:Macrolides / Q000494:pharmacology*; D016106:Methicillin Resistance / Q000235:genetics; D008826:Microbial Sensitivity Tests; D010641:Phenotype; D013045:Species Specificity; D013211:Staphylococcus aureus / Q000145:classification* / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification
D048628:Ketolides; D018942:Macrolides; C106791:telithromycin
Wrazliwość Staphylococcus aureus na nowe antybiotyki makrolidowe.