The infusion illusion.
Currently, the standard of care for high-risk peptic ulcer bleeding involves the use of a continuous intravenous proton pump inhibitor (PPI) infusion over 72 h. However, the article by Andruilli et al. details the results of a randomized controlled trial indicating that a less intensive regimen consisting of a once-daily bolus of PPI injection may lead to similar outcomes when compared to standard therapy. We will discuss these findings as well as comment on their validity, generalizability, and adaptability to clinical practice.
Targownik
Laura E
LE
Thomson
Peter A
PA
D006801:Humans; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D010438:Peptic Ulcer Hemorrhage / Q000188:drug therapy*; D054328:Proton Pump Inhibitors / Q000008:administration & dosage*; D016032:Randomized Controlled Trials as Topic
D054328:Proton Pump Inhibitors