The expression of integrinbeta1 and FAK in pituitary adenomas and their correlation with invasiveness.
The expression and possible role of integrin-focal adhesion kinase signal pathway in invasive pituitary adenomas were explored. Forty-nine human pituitary adenomas were detected for the expression of integrinbeta1 (INTbeta1) and focal adhesion kinase (FAK) by immunohistochemistry, and their correlation with the invasiveness of pituitary adenomas as well as between themselves was analyzed. The results showed that INTbeta1 was expressed in 46 cases (93.9%) and FAK in 36 cases (73.5%), respectively, and their expression levels were highly correlated with tumor invasiveness, but not with the tumor types. It was suggested that the integrin-focal adhesion kinase signal pathway plays a role in the invasiveness of pituitary adenomas.
Department of Neurosurgery, Tongji Hospital, Tongji Medical Collage, Huazhong University of Science and Technology, Wuhan 430030, China. wanruiyan@hotmail.com
Feng
F
Wang
Kai
K
Shu
Ting
T
Lei
Delin
D
Xue
D000236:Adenoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D051417:Focal Adhesion Kinase 1 / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D019012:Integrin beta1 / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010911:Pituitary Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D015398:Signal Transduction; D055815:Young Adult
D019012:Integrin beta1; D051417:Focal Adhesion Kinase 1; C496050:PTK2 protein, human