Basic mechanisms governing solute and fluid transport in hemodialysis.
Hemodialysis (HD) is primarily a diffusion-based transfer of small solutes. Diffusion is dependent on Fick's law. Convective removal, used mainly for removal of excess plasma water by ultrafiltration, also removes larger molecular-weight solutes by the process of solvent drag. A number of physicochemical factors operative on the blood and the dialysate side impact solute and water removal during HD. A comprehensive yet brief discussion of these 2 basic processes operative in HD is presented in this article.
Division of Nephrology, University of Missouri, Columbia, Missouri, USA. misram@health.missouri.edu
Madhukar
M
Misra
D001834:Body Water / Q000378:metabolism*; D015314:Dialysis Solutions / Q000493:pharmacokinetics*; D004058:Diffusion; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000628:therapy*; D006435:Renal Dialysis / Q000379:methods*
D015314:Dialysis Solutions