Accurate coarse-grained modeling of red blood cells.
We develop a systematic coarse-graining procedure for modeling red blood cells (RBCs) using arguments based on mean-field theory. The three-dimensional RBC membrane model takes into account the bending energy, in-plane shear energy, and constraints of fixed surface area and fixed enclosed volume. The coarse-graining procedure is general, it can be used for arbitrary level of coarse-graining and does not employ any fitting parameters. The sensitivity of the coarse-grained model is investigated and its behavior is validated against available experimental data and in dissipative particle dynamics (DPD) simulations of RBCs in capillary and shear flows.
Division of Applied Mathematics, Brown University, Providence, Rhode Island 02912, USA. piv@damn.brown.edu
Igor V
IV
Pivkin
George Em
GE
Karniadakis
D000465:Algorithms; D001783:Blood Flow Velocity / Q000502:physiology*; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism*; D003198:Computer Simulation; D004912:Erythrocytes / Q000737:chemistry / Q000378:metabolism*; D044085:Microfluidics / Q000379:methods*; D008954:Models, Biological; D010316:Particle Size; D033081:Shear Strength; D013314:Stress, Mechanical; D013499:Surface Properties; D013816:Thermodynamics