Combined 1H and 31P MR spectroscopic imaging: impaired energy metabolism in severe carotid stenosis and changes upon treatment.
OBJECTIVE
To evaluate if combined (1)H and (31)P MR spectroscopic imaging (MRSI) before and after treatment of severe internal carotid artery (ICA) stenosis detects significant changes in energy metabolism in the basal ganglia of both hemispheres.


METHODS
A group of 14 patients with high-grade ICA stenosis and 11 healthy control subjects were examined with 2D (1)H MRSI and 3D (31)P MRSI at 3 T before and after treatment of severe ICA stenosis. Spectroscopic data were processed with LCModel and jMRUI software. Changes of the phosphorylated metabolites, pH, N-acetyl-acetate, creatine and choline-containing compounds prior/post intervention were analyzed and patients' data were compared with that of control subjects.


RESULTS
Untreated patients had significantly higher Adenosindiphosphate (ADP) in basal ganglia ipsi- and contralateral to the side of ACI stenosis compared to controls. After treatment, ADP of both hemispheres significantly decreased by approximately 20% compared to the pre-treatment values. Further, significant decreases of phosphorylated metabolites prior/post intervention were found for patients compared to controls.


CONCLUSIONS
This spectroscopic study reveals that unilateral high-grade ICA stenosis has an effect on cerebral high-energy metabolism of both hemispheres, which is at least partially reversible after treatment. Therefore the restoration of blood flow in high-grade ICA stenosis recovers the impaired energy balance of the brain.
Hattingen
E
E
Institute of Neuroradiology, Johann Wolfgang Goethe University of Frankfurt/Main, Frankfurt/Main, Germany. elke.hattingen@kgu.de
Lanfermann
H
H
Menon
S
S
Neumann-Haefelin
T
T
de Rochement
R DuMesnil
RD
Stamelou
M
M
Höglinger
G U
GU
Magerkurth
J
J
Pilatus
U
U
D000368:Aged; D000369:Aged, 80 and over; D001479:Basal Ganglia / Q000098:blood supply / Q000503:physiopathology*; D016893:Carotid Stenosis / Q000503:physiopathology* / Q000601:surgery*; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010758:Phosphorus; D011522:Protons; D016896:Treatment Outcome
D011522:Protons; D010758:Phosphorus