Characterising vancomycin's immunotoxic profile using Swiss and CFW mice as an experimental model.
Immunotoxicology can lead to determining the adverse effects of different compounds on the immune system. Sometimes, many drugs (especially antibiotics) induce immune alterations, mainly auto-immunity. This study was aimed at determining vancomycin's immunotoxic effect by comparing the original molecule to two of the most used copies. Thirty-two mice from two murine strains (Swiss and CFW) were treated with three antibiotic formulations for studying its effect on splenic lymphoid and peripheral blood cell populations by using haemograms, flow cytometry and blastogenesis assays. The results indicated that vancomycin produces neutropenia and lymphocytosis in peripheral populations and that it induces a selective immunomodulatory effect on splenocyte sub-populations, depending on formulation and the strain so treated.
Salguero
Erica
E
Immunotoxicology Research Group, Pharmacy Department, Science Faculty, Universidad Nacional de Colombia, Bogotá, Colombia.
Plaza
David
D
Mariño
Angélica
A
Moreno
Carlos
C
Delgado
Gabriela
G
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000633:toxicity*; D016568:Drugs, Generic / Q000008:administration & dosage / Q000633:toxicity; D005260:Female; D005434:Flow Cytometry; D008213:Lymphocyte Activation / Q000187:drug effects; D008218:Lymphocytosis / Q000139:chemically induced*; D051379:Mice; D023421:Models, Animal; D009503:Neutropenia / Q000139:chemically induced*; D013045:Species Specificity; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D014640:Vancomycin / Q000008:administration & dosage / Q000633:toxicity*
D000900:Anti-Bacterial Agents; D016568:Drugs, Generic; D014640:Vancomycin