Functional properties of fibronectin in the trabecular meshwork.
Fibronectin plays a number of important roles in the extracellular matrix (ECM) including providing structural support and signaling cues for cell survival, migration, differentiation, gene expression, growth factor signaling, and cell contractility. In this review, we examine recent findings about the biological and structural properties of fibronectin and discuss how these properties could contribute to the regulation of aqueous humor (AH) outflow in the trabecular meshwork (TM).
Department of Pathology & Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA.
Jennifer A
JA
Faralli
Marie K
MK
Schwinn
Jose M
JM
Gonzalez
Mark S
MS
Filla
Donna M
DM
Peters
D001082:Aqueous Humor / Q000502:physiology; D005353:Fibronectins / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D017469:Receptors, Fibronectin / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013329:Structure-Activity Relationship; D014129:Trabecular Meshwork / Q000502:physiology*
D005353:Fibronectins; D017469:Receptors, Fibronectin