Aqueous solubilization of fullerenes using poly(amidoamine) dendrimers bearing cyclodextrin and poly(ethylene glycol).
Fullerene has a unique structure and notable chemical and physical properties, which have been studied in diverse fields including biological applications. The extremely poor solubility of fullerenes in water limits their usage for biomedical applications. In this study, we synthesized polyamidoamine dendrimers having both beta-cyclodextrin (CD) and poly(ethylene glycol) (PEG) and characterized the resulting dendrimers by (1)H NMR, IR, and gel permeation chromatography. We prepared 2.8 microM of aqueous fullerene solutions using these dendrimers. The clustering effect of CD and PEG at the surface of the dendrimer might be crucial for the solubilization of fullerene.
Graduate School of Engineering, Osaka Prefecture University, Osaka, Japan.
Chie
C
Kojima
Yoko
Y
Toi
Atsushi
A
Harada
Kenji
K
Kono
D003505:Cyclodextrins / Q000737:chemistry*; D050091:Dendrimers; D037741:Fullerenes / Q000737:chemistry*; D011073:Polyamines / Q000138:chemical synthesis / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D014867:Water / Q000737:chemistry*
D003505:Cyclodextrins; D050091:Dendrimers; D037741:Fullerenes; C104700:PAMAM Starburst; D011073:Polyamines; D014867:Water; D011092:Polyethylene Glycols