Infantile-onset diabetes mellitus: a 1-year follow-up study.
This study evaluates the clinical profiles and outcomes of children with infantile-onset diabetes mellitus (IODM) (onset at <1 year). Twelve infants with IODM presenting to our hospital from January 2003 to December 2007 are analyzed. All undergo thorough history, clinical examination, and investigations and are managed as per hospital-approved protocol and periodically followed up. Of 12 infants (3 boys and 9 girls), 9 have a family history of DM. The median age at onset is 2.5 months. Six infants have features suggestive of Wolcott-Rallison syndrome (WRS), 4 infants have type 1 DM, and 1 infant each has Fanconi-Bickel syndrome and maturity-onset diabetes of young. None have pancreatic agenesis or calculi. Human leukocyte antigen (HLA) typing shows DQ3 and DR15 alleles predominating. Two children with WRS died; the rest are being followed up. The incidence of IODM is increasing, with multiple syndromic associations rather than a single perspective.
Ganesh
Ramaswamy
R
Department of Pediatrics, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, India. ganeped79@rediffmail.com
Arvindkumar
Ravindrakumar
R
Vasanthi
Thiruvengadam
T
D017668:Age of Onset; D003241:Consanguinity; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006680:HLA Antigens / Q000097:blood / Q000235:genetics; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D007223:Infant; D007231:Infant, Newborn; D007328:Insulin / Q000008:administration & dosage; D008297:Male; D009154:Mutation; D010375:Pedigree; D016896:Treatment Outcome
D006680:HLA Antigens; D007004:Hypoglycemic Agents; D007328:Insulin