[The use of bisphosphonates for treating pathological states in orthopedics].
The bisphosphonates (BP) are well established as the treatment of choice for disorders of excessive bone resorption. Their classical pharmacological effects appear to result from two key properties: affinity for bone mineral and inhibitory effects on osteoclasts. Presented paper contains overview of the most important information concerning application of bisphosphonates in orthopedics. This compilation has been extended and includes also cellular mechanisms of action, pharmacological classification as well as adverse effects of this drugs' group. The most significant differences between the various individual BP and basic pharmacokinetic properties have been shown. This manuscript presents clinical guidelines on safe bisphosphonates usage.
Katedra i Klinika Ortopedii i Traumatologii, Pomorska Akademia Medyczna w Szczecinie.
Piotr
P
Białecki
Andrzej
A
Bohatyrewicz
Anna
A
Machoy-Mokrzyńska
Monika
M
Białecka
D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D001847:Bone Diseases / Q000188:drug therapy*; D001842:Bone and Bones / Q000187:drug effects; D004164:Diphosphonates / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D010006:Osteoblasts / Q000187:drug effects; D010010:Osteoclasts / Q000187:drug effects; D010011:Osteocytes / Q000187:drug effects; D016896:Treatment Outcome
D050071:Bone Density Conservation Agents; D004164:Diphosphonates
Zastosowanie bisfosfonianów w leczeniu schorzeń ortopedycznych.