Design of selective G-quadruplex ligands as potential anticancer agents.
G-quadruplex structures are promising targets for design of cancer drugs with high selectivity and low toxicity. This review provides an update of the progress made over the last few years in the design of selective G-quadruplex ligands, and a comprehensive summary of the major design strategies and structural characteristics.
Department of Applied Biology and Chemical Technology and State Key Lab of Chinese Medicine and Molecular Pharmacology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
Jia-Heng
JH
Tan
Lian-Quan
LQ
Gu
Jian-Yong
JY
Wu
D000595:Amino Acid Sequence; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity; D001483:Base Sequence; D004247:DNA / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D015195:Drug Design; D054856:G-Quadruplexes / Q000187:drug effects*; D006801:Humans; D008024:Ligands; D013379:Substrate Specificity
D000970:Antineoplastic Agents; D008024:Ligands; D004247:DNA