Mechanical and enzymatic thrombolysis of acute pulmonary embolus: review of the literature and cases from our institution.
Pulmonary embolism (PE) is a major cause of morbidity and mortality in the United States. Patients with massive PE have a high mortality rate, with two of every three deaths occurring in the first hour. The mainstay of treatment for PE is anticoagulation. However, when the patient is in extremis, intravenous lysis of the clot is indicated. Recently, mechanical fragmentation with or without pharmacologic thrombolysis has been shown to have a role in therapy for patients with massive PE, as well as in those patients who have a contraindication to anticoagulation. We discuss our experience with mechanical fragmentation in the treatment of PE and review the literature.
Department of Interventional Radiology, Montefiore Medical Center, Bronx, NY 10467, USA. jessicarosenblum@gmail.com
Jessica K
JK
Rosenblum
Jacob
J
Cynamon
D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use; D002407:Catheterization, Swan-Ganz / Q000379:methods; D017023:Coronary Angiography; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000628:therapy*; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000628:therapy; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy*; D015912:Thrombolytic Therapy / Q000379:methods; D016896:Treatment Outcome; D014481:United States; D020246:Venous Thrombosis / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*
D000925:Anticoagulants; D006493:Heparin