[A prospective study of serum high density lipoprotein cholesterol, cardiovascular and cerebrovascular risk in a Chinese muti-provinces cohort].
OBJECTIVE
To evaluate the association between serum HDL-C and the risk of cardiovascular diseases (CHD) in subjects aged 35-64 years.


METHODS
A prospective study was carried out in 11 provinces from 1992 to 2002. The association of baseline HDL-C level and cardiovascular disease occurrence was analyzed in 30384 subjects aged 35-64 years using Cox multivariate proportional hazards regression.


RESULTS
(1) Compared with the group of HDL-C > or = 1.56 mmol/L, multivariate-adjusted relative risk of ischemic cardiovascular disease (ICVD), including CHD and ischemic stroke increased continuously with decreased HDL-C level. (2) HDL-C level had different impact on different types of CVD. Positive association was observed between HDL-C level and the risk of ischemic stroke, but the relationship between HDL-C level and the risk of hemorrhagic stroke was indefinite. Compared with the group with HDL-C > or = 1.56 mmol/L, the risk of CHD of the group with HDL-C < or =1.03 mmol/L increased by 45% (RR = 1.45, P<0.05) and that of ischemic stroke increased by 53% (RR = 1.53, P <0.01). (3) 6.4% of ICVD, 7.2% of the acute CHD and 7.3% of the acute stroke was attributable to low serum high density lipoprotein cholesterol.


CONCLUSIONS
Starting from HDL-C > or = 1.56 mmol/L, the risk of ICVD increases continuously with decreased HDL-C level. Comprehensive intervention for multiple risk factor clustering should be strengthened to reduce theoverall risk of CVD.
Department of Epidemiology, Institute of Beijing Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital Affiliated to the Capital University of Medical Science, Bejing, China.
Qun
Q
Liu
Dong
D
Zhao
Wei
W
Wang
Jing
J
Liu
Jia-Yi
JY
Sun
Jun
J
Liu
D000328:Adult; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology; D002561:Cerebrovascular Disorders / Q000097:blood* / Q000453:epidemiology; D002681:China / Q000453:epidemiology; D008076:Cholesterol, HDL / Q000097:blood*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires
D008076:Cholesterol, HDL