The 769G>A variant of the inhibin-alpha gene in Korean patients with preeclampsia.
OBJECTIVE
Increased inhibin A serum and plasma levels in the second trimester are significantly associated with the development of preeclampsia. The measurement of inhibin A during early pregnancies may be helpful to predict those at risk of this disorder. The purpose of this study was to determine whether the 769G>A variant of the inhibin alpha (INHalpha) gene was associated with preeclampsia.


METHODS
We screened the 769G>A variation in 162 preeclamptic patients and in 202 normal pregnancies. The 769G>A variant of the INHalpha gene was determined by the PCR-based restriction fragment length polymorphism analysis and DNA sequencing.


RESULTS
We found no variation between the normal subjects and the preeclamptic patients.


CONCLUSIONS
The 769G>A variant of the INHalpha gene may be rare in Korean patients with preeclampsia.
Kim
S Y
SY
The Laboratory of Medical Genetics, Cheil General Hospital and Women's Healthcare Center, Kwandong University School of Medicine, Seoul, Korea.
Lim
J-H
JH
Yang
J-H
JH
Kim
M-Y
MY
Kim
M-H
MH
Park
S-Y
SY
Ryu
H-M
HM
D000328:Adult; D001483:Base Sequence; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007265:Inhibins / Q000235:genetics*; D007723:Korea; D008423:Maternal Age; D008969:Molecular Sequence Data; D017354:Point Mutation; D012150:Polymorphism, Restriction Fragment Length; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy
C094377:inhibin-alpha subunit; D007265:Inhibins