Intraductal papillary neoplasm of the bile duct associated with Clonorchis sinensis infection.
Intraductal papillary neoplasm of bile duct (IPNB) is one of the precursor lesions of cholangiocarcinoma. Although hepatolithiasis has been extensively studied in its association with IPNBs, there had been no comprehensive study of IPNBs with Clonorchis sinensis infection. Twelve IPNBs were selected from 20 surgically resected cholangiocarcinomas, positive for C. sinensis tests (60%) and compared with eight IPNBs, selected from 51 resected cholangiocarcinomas, negative for C. sinensis tests (16%), by histologic and immunohistochemical studies of mucin core proteins and cytokeratin panels. The predominant immuno-phenotype of IPNB cases with Clonorchiasis was pancreatobiliary type (MUC1+/MUC2-/CDX2-; 9/12 cases), while that of IPNB cases with negative for C. sinensis was intestinal type (MUC1-/MUC2+/CDX2+; 6/8; p = 0.04). The prevalence of IPNBs was higher when patients with cholangiocarcinoma had Clonorchiasis. IPNBs with Clonorchiasis tended to have a more pancreatobiliary phenotype, which suggests IPNBs with Clonorchiasis may have a different tumorigenesis pathway from IPNBs with other etiologies.
Department of Pathology, Samsung Medical Center, and Center of Clinical Research, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, Korea.
Kee-Taek
KT
Jang
Seung-Mo
SM
Hong
Kyu Taek
KT
Lee
Jong Gyun
JG
Lee
Seoung Ho
SH
Choi
Jin Seok
JS
Heo
Dong Wook
DW
Choi
Dongil
D
Choi
Jae Hoon
JH
Lim
D000368:Aged; D000818:Animals; D001650:Bile Duct Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000469:parasitology*; D001653:Bile Ducts, Intrahepatic; D000071616:CDX2 Transcription Factor; D018281:Cholangiocarcinoma / Q000175:diagnosis / Q000378:metabolism / Q000469:parasitology*; D003003:Clonorchiasis / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D003004:Clonorchis sinensis; D005260:Female; D018398:Homeodomain Proteins / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000378:metabolism / Q000469:parasitology; D008297:Male; D008875:Middle Aged; D055271:Mucin 5AC; D018396:Mucin-1 / Q000378:metabolism; D055262:Mucin-2 / Q000378:metabolism; D012189:Retrospective Studies
D000071616:CDX2 Transcription Factor; C491270:CDX2 protein, human; D018398:Homeodomain Proteins; C060192:MUC1 protein, human; C524625:MUC2 protein, human; C524678:MUC5AC protein, human; D055271:Mucin 5AC; D018396:Mucin-1; D055262:Mucin-2