Cortical serotonin 1A receptor levels are associated with depression in patients with dementia with Lewy bodies and Parkinson's disease dementia.
BACKGROUND
Serotonin 1A receptors (5-HT(1A)) have not been studied in dementia with Lewy bodies (DLB) or Parkinson's disease dementia (PDD) patients with depression.


OBJECTIVE
To examine 5-HT(1A) in DLB and PDD postmortem in relation to depression.


METHODS
[(3)H]8-hydroxy-2-dipropylaminotetralin binding to 5-HT(1A) was determined in temporal cortex (Brodmann areas, BA20 and BA36) from 10 DLB patients, 17 PDD patients and 9 controls.


RESULTS
5-HT(1A) density was significantly higher in BA36 in combined DLB/PDD patients with depression, but was unaltered in BA20.


CONCLUSIONS
Higher BA36 5-HT(1A) density in PDD and DLB patients than in control is dependent on whether the patient had experienced depression during life, not DLB/PDD diagnosis. A 5-HT(1A) antagonist adjuvant may improve treatment of depression in dementia.
Sharp
Sally I
SI
King's College London, Wolfson Centre for Age-Related Diseases, London, UK.
Ballard
Clive G
CG
Ziabreva
Iryna
I
Piggott
Margaret A
MA
Perry
Robert H
RH
Perry
Elaine K
EK
Aarsland
Dag
D
Ehrt
Uwe
U
Larsen
Jan P
JP
Francis
Paul T
PT
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000378:metabolism / Q000493:pharmacokinetics; D000368:Aged; D000369:Aged, 80 and over; D000928:Antidepressive Agents / Q000627:therapeutic use; D000978:Antiparkinson Agents / Q000627:therapeutic use; D001344:Autopsy; D002540:Cerebral Cortex / Q000378:metabolism*; D003704:Dementia / Q000150:complications / Q000378:metabolism* / Q000523:psychology*; D003863:Depression / Q000209:etiology / Q000378:metabolism* / Q000523:psychology*; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D020961:Lewy Body Disease / Q000150:complications / Q000378:metabolism* / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000523:psychology*; D044282:Receptor, Serotonin, 5-HT1A / Q000378:metabolism*; D017366:Serotonin Receptor Agonists / Q000378:metabolism / Q000493:pharmacokinetics; D013702:Temporal Lobe / Q000378:metabolism
D000928:Antidepressive Agents; D000978:Antiparkinson Agents; D017366:Serotonin Receptor Agonists; D044282:Receptor, Serotonin, 5-HT1A; D007980:Levodopa; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin