Effect of tulathromycin on the carrier status of Actinobacillus pleuropneumoniae serotype 2 in the tonsils of pigs.
The effect of a single or double dose of tulathromycin was evaluated in pigs carrying Actinobacillus pleuropneumoniae serotype 2 in their tonsils. Twenty-nine pigs from a reinfected specific pathogen-free-herd were selected from animals testing positive in an A pleuropneumoniae serotype 2-specific pcr test on tonsil scrapings and they were divided into three groups. The pigs in group 1 were treated subcutaneously with 2.5 mg/kg tulathromycin on day 0, the pigs in group 2 were treated with 2.5 mg/kg tulathromycin on days 0 and 4, and the pigs in group 3 were left untreated as controls. The pigs were tested by pcr on tonsil scrapings on days 0, 4, 11 and 33, and on day 33 all the animals were euthanased. There were no significant differences between the numbers of PCR-positive animals in the three groups on any of the sampling dates.
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National Veterinary Institute, Technical University of Denmark, Bülowsvej 27, dk-1790 Copenhagen, Denmark.
Andreasen
M
M
Nielsen
E O
EO
Stockmarr
A
A
Baekbo
P
P
D000189:Actinobacillus Infections / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D016977:Actinobacillus pleuropneumoniae / Q000145:classification / Q000187:drug effects*; D000818:Animals; D002353:Carrier State / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D003718:Denmark; D004187:Disaccharides / Q000008:administration & dosage*; D006571:Heterocyclic Compounds / Q000008:administration & dosage*; D008826:Microbial Sensitivity Tests; D014066:Palatine Tonsil / Q000382:microbiology*; D016133:Polymerase Chain Reaction; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy* / Q000382:microbiology; D018942:Macrolides
D004187:Disaccharides; D006571:Heterocyclic Compounds; C485204:tulathromycin; D018942:Macrolides