Quantitative assessment of lens opacities with anterior segment optical coherence tomography.
OBJECTIVE
To evaluate the reliability of lens density measurement with anterior segment optical coherence tomography (OCT) and its association with the Lens Opacity Classification System Version III (LOCS III) grading.


METHODS
Fifty-five eyes from 55 age-related cataract patients were included. One eye from each subject was selected at random for lens evaluation. After dilation, lens photographs were taken with a slit lamp and graded against the LOCS III standardised condition. Anterior segment OCT imaging was performed on the same eyes with a high-resolution scan. The association between the anterior segment OCT nucleus density measurement and LOCS III nuclear opalescence (NO) and nuclear colour (NC) scores was evaluated with the Spearman correlation coefficient. Anterior segment OCT measurement precision, coefficient of variation (CVw), and intraclass correlation coefficient (ICC) were calculated.


RESULTS
The mean NO and NC scores were 3.39 (SD 1.10) and 3.37 (SD 1.27), respectively. Significant correlations were found between anterior segment OCT nuclear density measurements and the LOCS III NO and NC scores (r = 0.77 and 0.60, respectively, both with p<0.001). The precision, CVw and ICC of anterior segment OCT measurement were 2.05 units, 4.55% and 0.98, respectively.


CONCLUSIONS
Anterior segment OCT nucleus density measurement is reliable and correlates with the LOCS III NO and NC scores.
Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong, PR China.
A L
AL
Wong
C K-S
CK
Leung
R N
RN
Weinreb
A K C
AK
Cheng
C Y L
CY
Cheung
P T-H
PT
Lam
C P
CP
Pang
D S C
DS
Lam
D000368:Aged; D000465:Algorithms; D000869:Anterior Eye Segment / Q000473:pathology; D002386:Cataract / Q000145:classification / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007907:Lens Nucleus, Crystalline / Q000473:pathology; D008297:Male; D010781:Photography; D015203:Reproducibility of Results; D041623:Tomography, Optical Coherence / Q000379:methods*