Cervical lymphadenopathy: scrofula revisited.
BACKGROUND
The commonest form of extrapulmonary tuberculosis is tubercular cervical lymphadenitis, or scrofula.


RESULTS
A total of 1827 patients with cervical lymphadenopathy who presented to various out-patients clinics of our institution were studied over a three-year period. Eight hundred and ninety-three (48.87 per cent) of these patients had lesions of tubercular origin. The most common observation was unilateral, matted adenopathy in female patients aged between 11 and 20 years and without constitutional symptoms of tuberculosis. Posterior triangle nodes were affected in 43.8 per cent of cases, followed by upper deep cervical nodes in 33.9 per cent. Fine needle aspiration cytology constituted the main diagnostic tool, with a positive yield in 90 per cent of patients. Polymerase chain reaction analysis was performed in 126 patients, with a sensitivity of 63 per cent. Only 18 per cent of patients had associated pulmonary tuberculosis, the rest having isolated involvement of cervical nodes. Medical treatment with anti-tubercular drugs for a period of six months formed the mainstay of treatment and cure. Surgical management was reserved for selected refractory patients.


CONCLUSIONS
Tubercular cervical lymphadenitis can readily be diagnosed by fine needle aspiration cytology, a simple and cost-effective test. The disease can be cured completely by a short course of anti-tubercular chemotherapy, without surgical intervention.
Department of Pathology, J N Medical College, Aligarh Muslim University, Uttar Pradesh, India.
R
R
Khan
S H
SH
Harris
A K
AK
Verma
A
A
Syed
D000293:Adolescent; D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000627:therapeutic use; D044963:Biopsy, Fine-Needle; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009333:Neck; D016133:Polymerase Chain Reaction; D014388:Tuberculosis, Lymph Node / Q000188:drug therapy / Q000473:pathology*; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis; D055815:Young Adult
D000995:Antitubercular Agents