Estrogen regulation of proteins in the rat ventromedial nucleus of the hypothalamus.
The effects of estradiol (E2) on the expression of proteins in the pars lateralis of the ventromedial nucleus of the hypothalamus (VMNpl) in ovariectomized rats was studied using 2-dimensional gel electrophoresis followed by RPLC-nanoESI-MS/MS. E2 treatment resulted in the up-regulation of 29 identified proteins. Many of these proteins are implicated in the promotion of neuronal plasticity and signaling.
Department of Biology and Neuroscience Group, University of South Dakota, Vermillion, South Daklota 57069, USA.
Bing
B
Mo
Eduardo
E
Callegari
Martin
M
Telefont
Kenneth J
KJ
Renner
D000818:Animals; D001686:Biological Phenomena; D004958:Estradiol / Q000494:pharmacology*; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects*; D010052:Ovariectomy; D011506:Proteins / Q000378:metabolism*; D040901:Proteomics / Q000379:methods; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014697:Ventromedial Hypothalamic Nucleus / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism
D004967:Estrogens; D011506:Proteins; D004958:Estradiol