Repeated high doses of clopidogrel in 2 cases of pharmacological resistance.
In the case of stent thrombosis and resistance to clopidogrel, choices of an alternative drug remain limited. In 2 cases of subacute stent thrombosis associated with clopidogrel resistance, an adequate response was obtained in these patients after repeated loading doses of clopidogrel.
Department of Cardiology, Hôpital Arnaud de Villeneuve, Centre Hospitalier Universitaire, Montpellier, France. guillaumecayla@free.fr
Guillaume
G
Cayla
Jean Christophe
JC
Macia
François
F
Roubille
Herisoa
H
Rabesendratana
Christophe
C
Piot
Jean François
JF
Schved
Florence
F
Leclercq
D054058:Acute Coronary Syndrome / Q000628:therapy*; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000097:blood; D000077144:Clopidogrel; D004334:Drug Administration Schedule; D004351:Drug Resistance; D006801:Humans; D008297:Male; D008840:Microfilament Proteins / Q000097:blood; D008875:Middle Aged; D010750:Phosphoproteins / Q000097:blood; D010766:Phosphorylation; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D010979:Platelet Function Tests; D013927:Thrombosis / Q000209:etiology / Q000517:prevention & control*; D013988:Ticlopidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D017211:Treatment Failure; D000098662:Vasodilator-Stimulated Phosphoprotein
D015815:Cell Adhesion Molecules; D008840:Microfilament Proteins; D010750:Phosphoproteins; D010975:Platelet Aggregation Inhibitors; D000098662:Vasodilator-Stimulated Phosphoprotein; D000077144:Clopidogrel; D013988:Ticlopidine