119Sb--a potent Auger emitter for targeted radionuclide therapy.
Auger electron emitting radionuclides in cancer therapy offer the opportunity to deliver a high radiation dose to the tumor cells with high radiotoxicity while minimizing toxicity to normal tissue. We have in this study identified the Auger emitter 119Sb as a potent nuclide for targeted radionuclide therapy based on theoretical dosimetry calculations at a subcellular scale. From these calculations we have determined the cellular S-values for this therapeutic isotope. Moreover, we have demonstrated the possibility of producing this isotope and also the SPECT-analogue 117Sb for patient-specific dosimetry, by measuring the proton irradiation yields for both isotopes using a low-energy cyclotron. The excellent SPECT imaging properties of the 117Sb radionuclide have been shown by scanning a Jaszczak SPECT Phantom.
The Hevesy Laboratory, Radiation Research Department, Risoe National Laboratory for Sustainable Energy, Technical University of Denmark, P.O. 49, DK-4000 Roskilde, Denmark. helge.thisgaard@risoe.dk
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Thisgaard
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Jensen
D000965:Antimony / Q000627:therapeutic use*; D004583:Electrons; D006801:Humans; D019047:Phantoms, Imaging; D011868:Radioisotopes / Q000627:therapeutic use*; D019275:Radiopharmaceuticals / Q000627:therapeutic use*; D015899:Tomography, Emission-Computed, Single-Photon
D011868:Radioisotopes; D019275:Radiopharmaceuticals; D000965:Antimony