Murine renal ischaemia-reperfusion injury.
Ischaemia/reperfusion is a major cause of acute kidney injury in native and transplant kidneys and is associated with significant morbidity and mortality. Murine models of renal ischaemia/reperfusion injury have great potential to improve understanding of the underlying processes and are an important focus of ongoing research into therapeutic and preventative strategies. Like all experimental models, murine models of renal ischaemia/reperfusion are prone to significant variability and results may be influenced by a number of technical and design factors. In this article we review the factors that may influence experimental results and provide a guide to conducting reproducible experiments in murine renal ischaemia/reperfusion.
Kennedy
Sean E
SE
Department of Nephrology, Sydney Children's Hospital, Randwick, New South Wales, Australia.
Erlich
Jonathan H
JH
D000818:Animals; D004195:Disease Models, Animal; D016030:Kidney Transplantation / Q000379:methods*; D051379:Mice; D015427:Reperfusion Injury / Q000503:physiopathology*