Transcriptional changes in human Caco-2 colon cancer cells following exposure to a recurrent non-toxic dose of polyphenol-rich chokeberry juice.
Berries and red fruits are important dietary sources of polyphenols [1]. In vitro and animal studies have demonstrated the bioavailability and the anti-proliferative and anticarcinogenic properties of these fruits or of their phenolic components [2, 3]. Consumption of berries may contribute to the reduction of colon cancer by mechanisms not yet understood. Gene expression analysis using microarrays allows for a more comprehensive study of the possible molecular mechanisms by which food or food components may prevent certain cancers of the gastrointestinal tract [4]. The aim of this research is to investigate the anti-proliferative effects of a polyphenol-rich berry juice on a human model of colon cancer cells and its association to transcriptional changes in relation to colon cancer.
Research Group on Quality, Safety and Bioactivity of Plant Foods, Food Science and Technology, CEBAS-CSIC, Campus de Espinardo, 30100, Murcia, Spain.
M J
MJ
Bermúdez-Soto
M
M
Larrosa
J
J
García-Cantalejo
J C
JC
Espín
F A
FA
Tomás-Barberan
M T
MT
García-Conesa