Sequential Ewing's sarcoma and osteosarcoma.
The sequential occurrence of two primary bone tumors, Ewing's sarcoma and osteosarcoma in the same patient at two different anatomical sites 5 years apart is rare. We report a case of 12-year-old boy who after treatment for Ewing's sarcoma of proximal fibula subsequently presented, 4 years later, with a high-grade fibroblastic osteosarcoma of the proximal humerus. The patient was also found to have a rare gene tranlocation t (7;22) instead of the more common t (11;22).
Sharma
Vivek
V
Department of Orthopaedic Surgery, University of Minnesota, Minneapolis, MN 55454, USA. vivorth227@yahoo.com
Crawford
Alvin H
AH
Evans
Jonathan
J
Collins
Margaret H
MH
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D002648:Child; D002892:Chromosomes, Human, Pair 22; D002897:Chromosomes, Human, Pair 7; D003131:Combined Modality Therapy; D005360:Fibula / Q000473:pathology; D006801:Humans; D006811:Humerus / Q000473:pathology; D008297:Male; D016609:Neoplasms, Second Primary / Q000235:genetics / Q000473:pathology*; D012516:Osteosarcoma / Q000235:genetics / Q000473:pathology*; D018714:Radiotherapy, Adjuvant; D012512:Sarcoma, Ewing / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D014178:Translocation, Genetic