Effect of glucosamine sulphate on joint space narrowing, pain and function in patients with hip osteoarthritis; subgroup analyses of a randomized controlled trial.
OBJECTIVE
Recently we reported that glucosamine sulphate (GS) did not have an effect on the symptoms and progression of primary care patients with hip osteoarthritis (OA). The aim of this present study was to investigate whether there are subgroups of patients with hip OA for whom GS might be an effective therapy.


METHODS
We randomized 222 patients with hip OA that met one of the American College of Rheumatology criteria to either 1500 mg of oral GS or placebo once daily for 2 years. Subgroup analyses were predefined for radiographic severity (Kellgren & Lawrence (KL)=1 vs >or=2) and for type of OA (localised vs generalised). Additional exploratory subgroup analyses focused on groups based on pain level, pain medication use, baseline joint space width (JSW), and concomitant knee OA at baseline. Primary outcome measures were Western Ontario MacMaster Universities (WOMAC) pain and function scores over 24 months, and joint space narrowing (JSN) after 24 months.


RESULTS
In the predefined subgroups based on radiographic severity and type of OA, the outcomes WOMAC pain, function and JSN were similar for the GS and placebo group.


CONCLUSIONS
GS was not significantly better than placebo in reducing symptoms and progression of hip OA in subgroups of patients.
Department of General Practice, Erasmus MC, University Medical Center Rotterdam, The Netherlands. r.rozendaal@erasmusmc.nl
R M
RM
Rozendaal
E J
EJ
Uitterlinden
G J V M
GJ
van Osch
E H
EH
Garling
S P
SP
Willemsen
A Z
AZ
Ginai
J A N
JA
Verhaar
H
H
Weinans
B W
BW
Koes
S M A
SM
Bierma-Zeinstra
D000368:Aged; D019587:Dietary Supplements; D018450:Disease Progression; D004311:Double-Blind Method; D005260:Female; D005944:Glucosamine / Q000627:therapeutic use*; D006621:Hip Joint / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D010147:Pain Measurement / Q000379:methods; D011859:Radiography; D012720:Severity of Illness Index; D016896:Treatment Outcome
D005944:Glucosamine