Natural gum reduced/stabilized gold nanoparticles for drug delivery formulations.
"Gellan Gum", widely used in food and confectionary industry as a thickening and gelling agent, has been employed as a reducing and stabilizing agent for the synthesis of gold nanoparticles. These nanoparticles display greater stability to electrolyte addition and pH changes relative to the traditional citrate and borohydride reduced nanoparticles. Subsequently these have been used to load anthracycline ring antibiotic doxorubicin hydrochloride. The drug loaded on these nanoparticles showed enhanced cytotoxic effects on human glioma cell lines LN-18 and LN-229.
Dhar
Sheetal
S
Materials Chemistry Division, National Chemical Laboratory, Pune, India.
Reddy
E Maheswara
EM
Shiras
Anjali
A
Pokharkar
Varsha
V
Prasad
B L V
BL
D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002626:Chemistry, Pharmaceutical; D004317:Doxorubicin / Q000494:pharmacology; D006046:Gold / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission; D015394:Molecular Structure; D011135:Polysaccharides, Bacterial / Q000737:chemistry*; D013053:Spectrophotometry
D011135:Polysaccharides, Bacterial; D006046:Gold; C048288:gellan gum; D004317:Doxorubicin