Distribution of serotypes and antibiotic resistance of invasive pneumococcal disease isolates among children aged 5 years and under in Saudi Arabia (2000-2004).
To determine vaccine coverage of invasive pneumococcal disease (IPD) in Saudi Arabian children aged 5 years and under, 350 IPD isolates were tested for antibiotic susceptibility. Of these 46%, 42% and 12% were penicillin-sensitive, pencillinintermediate, and penicillin-resistant, respectively. Rates of resistance to erythromycin and cefotaxime were 26% and 6%, respectively. The potential serotype coverage of the PCV7 vaccine in Saudi Arabia among children <5 years of age is 62%, and vaccine coverage significantly improved in children <2 years of age, to reach 83% against IPD isolates. PCV7 is expected to have a substantial impact on the burden of invasive and antibiotic-resistant pneumococcal disease in Saudi Arabia.
King Saud University, Riyadh, Saudi Arabia.
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D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002675:Child, Preschool; D004352:Drug Resistance, Microbial; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D007223:Infant; D022401:Meningococcal Vaccines / Q000276:immunology; D008826:Microbial Sensitivity Tests; D011008:Pneumococcal Infections / Q000382:microbiology*; D022242:Pneumococcal Vaccines / Q000276:immunology; D012529:Saudi Arabia; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000187:drug effects* / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022401:Meningococcal Vaccines; D022242:Pneumococcal Vaccines