Kinetic resolution of racemic alcohols using thioamide modified 1-methyl-histidine methyl ester.
The low-molecular-weight and easily prepared N-thiobenzoyl 1-methyl-histidine methyl ester 3k was utilized to efficiently catalyze the kinetic resolution of racemic secondary alcohols. Comparison of the conformations of amide catalyst 3c and thioamide catalyst 3k was made to understand the origin of the improvement of the enantioselectivity by thioamide modification.
The State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, PR China.
Xue-Li
XL
Geng
Jia
J
Wang
Guo-Xing
GX
Li
Peng
P
Chen
Shu-Fang
SF
Tian
Jin
J
Qu
D000438:Alcohols / Q000737:chemistry / Q000302:isolation & purification*; D000577:Amides; D006639:Histidine / Q000031:analogs & derivatives* / Q000737:chemistry; D007700:Kinetics; D008968:Molecular Conformation; D013237:Stereoisomerism; D013854:Thioamides / Q000737:chemistry*
D000438:Alcohols; D000577:Amides; D013854:Thioamides; D006639:Histidine; C053861:histidine methyl ester