Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR-gamma signal pathways.
Ginsenosides, the active component of ginseng, exerts antidiabetic and anticancer effects. This study investigated the molecular basis of ginsenoside Rg3, a red ginseng rich constituent, focusing on its ability to inhibit adipocyte differentiation in 3T3-L1 cells. The data show that ginsenoside Rg3 was effective in the inhibition of adipocyte differentiation. This inhibitory effect of ginsenoside Rg3 on adipocyte differentiation was accompanied by PPAR-gamma inhibition in rosiglitazone-treated cells. The study also tested whether AMP-activated protein kinase (AMPK) activation was involved in the inhibitory effects of ginsenoside Rg3. AMPK plays a role in maintaining health in the context of diseases such as type 2 diabetes, obesity and cancer. AMPK was reported to control nutritional and hormonal signal modulating. Rg3 significantly and time-dependently activated AMPK. Taken together, these results suggest that the antiobesity effect of red ginseng rich constituent, ginsenoside Rg3, involves the AMPK signaling pathway and PPAR-gamma inhibition.
Hwang
Jin-Taek
JT
Food Function Research Center, Korea Food Research Institute, Songnam, Kyoungki-do, 463-746, Republic of Korea.
Lee
Myoung-Su
MS
Kim
Hyun-Jin
HJ
Sung
Mi-Jeong
MJ
Kim
Hye Young
HY
Kim
Myung Sunny
MS
Kwon
Dae Young
DY
D041721:3T3-L1 Cells; D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects*; D020536:Enzyme Activators / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D036145:Ginsenosides / Q000494:pharmacology*; D051379:Mice; D047495:PPAR gamma / Q000037:antagonists & inhibitors / Q000378:metabolism*; D005894:Panax / Q000737:chemistry*; D015398:Signal Transduction / Q000187:drug effects
D019440:Anti-Obesity Agents; D020536:Enzyme Activators; D004791:Enzyme Inhibitors; D036145:Ginsenosides; D047495:PPAR gamma; C097367:ginsenoside Rg3; D055372:AMP-Activated Protein Kinases