Effects of 6 months exercise training on ventricular remodelling and autonomic tone in patients with acute myocardial infarction and percutaneous coronary intervention.
OBJECTIVE
To study the effects of 6 months exercise training on ventricular remodelling and autonomic tone in patients with acute myocardial infarction and percutaneous coronary intervention.


METHODS
Single-blinded randomized control trial.


METHODS
Sixty patients with acute myocardial infarction who had undergone percutaneous coronary intervention.


METHODS
The exercise group followed a 6-month supervised exercise programme, while the control group received routine recommendations. All patients underwent an incremental cardiopulmonary exercise test and Doppler echocardiography at baseline and after 6 months.


RESULTS
Three patients in the exercise group did not complete the programme. At 6 months follow-up, an improvement was seen in the exercise group compared with the control group regarding peak VO2 (p<0.01), Powermax (p<0.05), VO2 at anaerobic threshold (p<0.01), time to reach anaerobic threshold (p<0.05), heart rate recovery (p<0.01), left ventricular end-diastolic diameter (p<0.01) and left ventricular ejection fraction (p<0.05).


CONCLUSIONS
Six months exercise training in patients with acute myocardial infarction and percutaneous coronary intervention with mild ventricular systolic dysfunction could prevent ventricular remodelling to a certain extent, and favourable modulating sympatho-vagal balance may be an important mechanism.
Department of Cardiology, Tongji Hospital of Tongji University, Shanghai, China.
Huan
H
Zheng
Ming
M
Luo
Yi
Y
Shen
Yuan
Y
Ma
Wenhui
W
Kang
D000328:Adult; D015906:Angioplasty, Balloon, Coronary; D015150:Echocardiography, Doppler; D005080:Exercise Test; D005081:Exercise Therapy / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000503:physiopathology / Q000534:rehabilitation* / Q000628:therapy; D010101:Oxygen Consumption / Q000502:physiology; D016037:Single-Blind Method; D013997:Time Factors; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology / Q000534:rehabilitation / Q000628:therapy; D020257:Ventricular Remodeling / Q000502:physiology