Can chronic recurrent multifocal osteomyelitis predispose to lymphoma of bone? A case report.
Chronic recurrent multifocal osteomyelitis (CRMO) and B-cell lymphoma are fairly uncommon conditions that are seen in children. Although CRMO can leave patients with residual deformities and disabilities, it is a benign condition. We describe an unusual situation in which a site adjacent to a biopsy-documented site of CRMO presented 3.5 years later with B-cell lymphoma. B-cell lymphoma can behave in an indolent manner and reports suggest that this condition can initially be mistaken for CRMO. This case presented here underscores the importance of vigilance in the short and long-term management of patients initially diagnosed with CRMO, and raises the possibility that the pathogenesis of the two conditions is related.
Division of Pediatric Orthopaedics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada. pjellicoe@doctors.org.uk
Paul
P
Jellicoe
Sevan
S
Hopyan
D000293:Adolescent; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D002908:Chronic Disease; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D008297:Male; D010019:Osteomyelitis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D011859:Radiography; D012008:Recurrence; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents