Effect of fluoroquinolones on body temperature of mice.
OBJECTIVE
The purpose of this study was to assess the effect of fluoroquinolones on rectal temperature of infected and non-infected mice.


METHODS
The effect of fluoroquinolone administration on rectal temperature was investigated in a mouse model with and without infection.


RESULTS
Hypothermia was induced by administration of gatifloxacin at doses of 1 and 10 mg/kg in non-infected mice, but not by cefditoren pivoxil. In addition, the rectal temperature was decreased in infected mice administered fluoroquinolones or cephems, a greater decrease being noted in animals receiving the former agents.


CONCLUSIONS
This study shows that fluoroquinolones decrease the rectal temperature of mice regardless of infections.
Miyazaki
Shuichi
S
Department of Microbiology and Infectious Disease, Toho University Faculty of Medicine School of Medicine, Tokyo, Japan. shuichi@med.toho-u.ac.jp
Ishikawa
Fumio
F
Matsuo
Saburo
S
Yamaguchi
Keizo
K
D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D002511:Cephalosporins / Q000494:pharmacology*; D024841:Fluoroquinolones / Q000494:pharmacology*; D000077734:Gatifloxacin; D051379:Mice; D012007:Rectum / Q000502:physiology
D018712:Analgesics, Non-Narcotic; D002511:Cephalosporins; D024841:Fluoroquinolones; C057710:cefditoren pivoxil; D000077734:Gatifloxacin