[Evaluation of targeting property for Kuikang colon targeted pellets].
OBJECTIVE
To evaluate colon targeting characteristic of Kuikang colon targeted pellets (KCP) with determination of residual baicalin and baicalein concentration in gastrointestinal tract (GIT).


METHODS
The baicalin and baicalein were assayed by HPLC. The recovery differences of the drug between KCP and conventional pellets from GIT were investigated, three and six hours after administration.


RESULTS
The baicalin recovery of KCP (70%) from rat GIT was higher than that of CP (about 20%). Most of KCP were intact at 3 h after oral administration, and distributed in lower ileum. It indicated that release site of KCP was in lower ileum and colon. Six hours later, a small amount of baicalin was recovered in intestime, which showed that the release of baicalin from KCP was complete.


CONCLUSIONS
The determination of residual baicalin in rat GIT was feasibility for evaluating KCP. The result confirmed KCP of colon targeting property.
College of Life Science, Northwest University, Xi'an 710069, China. zyjljy@163.com
Ya-Jun
YJ
Zhang
Jiang-Ying
JY
Li
Lian-Ying
LY
Xu
D000818:Animals; D003106:Colon / Q000378:metabolism*; D016503:Drug Delivery Systems; D004343:Drug Implants; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000378:metabolism*; D044950:Flavanones / Q000378:metabolism; D005419:Flavonoids / Q000378:metabolism; D007082:Ileum / Q000378:metabolism; D016015:Logistic Models; D051381:Rats; D017208:Rats, Wistar
D004343:Drug Implants; D004365:Drugs, Chinese Herbal; D044950:Flavanones; D005419:Flavonoids; C540474:kuikang; C038044:baicalin; C006680:baicalein