[Effects of guanxin II on cardiac protein expression after acute myocardial ischemia on rats].
OBJECTIVE
Guanxin II is a famous modern formula of traditional Chinese medicine. Guanxin II after myocardial infarction (MI) has been shown to have beneficial effects on cardiac anatomy and function. The purpose of this study was to examine the effects of Guanxin 1I on cardiac protein expression after MI.


METHODS
Rats were randomized into 3 groups, sham, model and treating groups. Model and treating groups were fed with Guanxin II and sham group was fed with water for 10 days before MI. MI operation is to ligate left coronary artery. 24 hours after MI, myocardial protein expression of junctional zone was assessed with 2D gel electrophoresis and mass spectra analysis.


RESULTS
Guanxin II was found to be able to improve myocardial protein expression, especially 11 proteins. These proteins are mainly involved in suppressing changes of cell shape and structure and energy metabolism.


CONCLUSIONS
Guanxin II after MI affected myocardial protein expression. Further experiments of larger research extent should be done to receive more results.
Beijing Shijitan Hospital, Beijing 100038, China.
Cheng-Yao
CY
Yu
Zhen
Z
Liu
Xin-Min
XM
Xu
Yi-Kui
YK
Li
Lian-Da
LD
Li
D000818:Animals; D048430:Cell Shape / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects; D005786:Gene Expression Regulation / Q000187:drug effects*; D006321:Heart / Q000187:drug effects*; D008297:Male; D009124:Muscle Proteins / Q000378:metabolism*; D017202:Myocardial Ischemia / Q000378:metabolism* / Q000473:pathology*; D009206:Myocardium / Q000378:metabolism*; D051381:Rats
D004365:Drugs, Chinese Herbal; D009124:Muscle Proteins; C539574:guanxin No. 2