Emergence of amantadine-resistant H3N2 avian influenza A virus in South Korea.
We found a relatively high frequency of unique amantadine-resistant H3N2 and H9N2 avian influenza viruses (Val27Ile on M2 protein) isolated from live poultry markets in South Korea and confirmed that a Val27Ile single substitution in the M2 protein is enough to acquire the amantadine resistance phenotype by using reverse-genetically created human-avian reassortant viruses.
Lee
Jiyeon
J
College of Medicine and Medical Research Institute, Chungbuk National University, 12 Gaeshin-Dong Heungduk-Ku, Cheongju 361-763, Republic of Korea.
Song
Young Jun
YJ
Park
Jeung Hyun
JH
Lee
Jun-Han
JH
Baek
Yun Hee
YH
Song
Min-Suk
MS
Oh
Taek-Kyu
TK
Han
Heon-Seok
HS
Pascua
Philippe Noriel Q
PN
Choi
Young-Ki
YK
D000547:Amantadine / Q000494:pharmacology*; D019943:Amino Acid Substitution / Q000235:genetics; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D024882:Drug Resistance, Viral; D053122:Influenza A Virus, H3N2 Subtype / Q000187:drug effects* / Q000302:isolation & purification; D053127:Influenza A Virus, H9N2 Subtype / Q000187:drug effects / Q000302:isolation & purification; D005585:Influenza in Birds / Q000821:virology*; D007723:Korea; D008969:Molecular Sequence Data; D020125:Mutation, Missense; D011200:Poultry; D011201:Poultry Diseases / Q000821:virology*; D012367:RNA, Viral / Q000235:genetics; D016865:Reassortant Viruses / Q000187:drug effects / Q000235:genetics; D017422:Sequence Analysis, DNA; D014763:Viral Matrix Proteins / Q000235:genetics; D000086082:Viroporin Proteins
D000547:Amantadine; D000998:Antiviral Agents; D012367:RNA, Viral; D014763:Viral Matrix Proteins; C488937:M2 protein, Influenza A virus; D000086082:Viroporin Proteins