Isolated extra-medullary relapse of acute leukemia following allogeneic bone marrow transplantation.
Isolated extramedullary relapse (IEMR) of acute leukemia (AL) after allogeneic bone marrow transplantation (BMT) is a rare occurrence. It is seen more commonly after BMT than after conventional chemotherapy (CHT) alone. We describe the natural history and response to treatment in four patients with IEMR following allogeneic BMT. The results indicate a stronger graft-versus-leukemia (GVL) effect in the marrow than in the peripheral tissues (Fig. 4, Ref. 13). Full Text (Free, PDF) www.bmj.sk.
Department of Hematology and Transfusion Medicine, Faculty of Medicine, University Hospital, Comenius University, Bratislava, Slovakia. firasalsabty@yahoo.com
Al Sabty
AS
Firas
E
E
Demeckova
E
E
Bojtarova
B
B
Czako
M
M
Hrubisko
M
M
Mistrik
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D001921:Brain / Q000473:pathology; D001940:Breast / Q000473:pathology; D005260:Female; D020544:Graft vs Leukemia Effect; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000601:surgery*; D017254:Leukemic Infiltration / Q000209:etiology* / Q000473:pathology; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000601:surgery*; D012867:Skin / Q000473:pathology; D014184:Transplantation, Homologous / Q000009:adverse effects