Reversed chloroquines based on the 3,4-dihydropyrimidin-2(1H)-one scaffold: synthesis and evaluation for antimalarial, beta-haematin inhibition, and cytotoxic activity.
October
Natasha
N
Department of Chemistry, University of Cape Town, Rondebosch, South Africa.
Watermeyer
Nicholas D
ND
Yardley
Vanessa
V
Egan
Timothy J
TJ
Ncokazi
Kanyile
K
Chibale
Kelly
K
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D002738:Chloroquine / Q000737:chemistry* / Q000494:pharmacology; D015195:Drug Design; D006420:Hemeproteins / Q000037:antagonists & inhibitors*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008954:Models, Biological; D008956:Models, Chemical; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000378:metabolism*; D013329:Structure-Activity Relationship
D000962:Antimalarials; D006420:Hemeproteins; D011743:Pyrimidines; C020753:hemozoin; D002738:Chloroquine