Memory reconsolidation mediates the strengthening of memories by additional learning.
Memories are dynamic, rather than static, in nature. The reactivation of a memory through re-exposure to salient training stimuli results in its destabilization, necessitating a restabilization process known as reconsolidation, a disruption of which leads to amnesia. I found that one normal function of hippocampal memory reconsolidation in rats is to modify the strength of a contextual-fear memory as a result of further learning.
School of Psychology, University of Birmingham, Edgbaston, Birmingham, UK. j.l.c.lee@bham.ac.uk
Jonathan L C
JL
Lee
D000647:Amnesia / Q000139:chemically induced / Q000503:physiopathology; D000704:Analysis of Variance; D000818:Animals; D000841:Anisomycin / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D019208:Brain-Derived Neurotrophic Factor / Q000737:chemistry; D003213:Conditioning, Psychological / Q000187:drug effects; D051766:Early Growth Response Protein 1 / Q000737:chemistry; D005239:Fear / Q000187:drug effects; D046352:Freezing Reaction, Cataleptic / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects; D007783:Lactones / Q000494:pharmacology; D007858:Learning / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D020319:Oligodeoxyribonucleotides, Antisense / Q000494:pharmacology; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D051381:Rats
D019208:Brain-Derived Neurotrophic Factor; D051766:Early Growth Response Protein 1; C486110:Egr1 protein, rat; D007783:Lactones; D020319:Oligodeoxyribonucleotides, Antisense; D011500:Protein Synthesis Inhibitors; C098869:clasto-lactacystin beta-lactone; D000841:Anisomycin