Fatty acid-based polyurethane films for wound dressing applications.
Fatty acid-based polyurethane films were prepared for use as potential wound dressing material. The polymerization reaction was carried out with or without catalyst. Polymer films were prepared by casting-evaporation technique with or without crosslink-catalyst. The film prepared from uncatalyzed reaction product with crosslink-catalyst gave slightly higher crosslink density. The mechanical tests showed that, the increase in the tensile strength and decrease in the elongation at break is due to the increase in the degree of crosslinking. All films were flexible, and resisted to acid solution. The films prepared without crosslink-catalyst were more hydrophilic, absorbed more water. The highest permeability values were generally obtained for the films prepared without crosslink catalyst. Both the direct contact method and the MMT test were applied for determination of cytotoxicity of polymer films and the polyurethane film prepared from uncatalyzed reaction product without crosslink-catalyst showed better biocompatibility property, closest to the commercial product, Opsite.
Delft University of Technology, Delft Chem Tech, 2600 GA, Delft, The Netherland.
Guncem
G
Gultekin
Cigdem
C
Atalay-Oral
Sibel
S
Erkal
Fikret
F
Sahin
Djursun
D
Karastova
S Birgul
SB
Tantekin-Ersolmaz
F Seniha
FS
Guner
D000818:Animals; D001458:Bandages; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D001696:Biomechanical Phenomena; D049109:Cell Proliferation / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D003432:Cross-Linking Reagents; D004548:Elasticity; D005227:Fatty Acids / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D009682:Magnetic Resonance Spectroscopy; D008422:Materials Testing; D051379:Mice; D015394:Molecular Structure; D008970:Molecular Weight; D041681:NIH 3T3 Cells; D011140:Polyurethanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013718:Tensile Strength; D013816:Thermodynamics; D014783:Viscosity
D001672:Biocompatible Materials; D020099:Coated Materials, Biocompatible; D003432:Cross-Linking Reagents; D005227:Fatty Acids; D011140:Polyurethanes