Serum levels of the adipokine FGF21 depend on renal function.
OBJECTIVE
To investigate renal elimination of the adipokine fibroblast growth factor 21 (FGF21) by determining circulating FGF21 levels in patients on chronic hemodialysis (CD) as compared with control subjects with a glomerular filtration rate (GFR) >50 ml/min.


METHODS
FGF21 was determined by enzyme-linked immunosorbent assay in control (n = 60) and CD (n = 60) patients and correlated to clinical and biochemical measures of renal function, glucose and lipid metabolism, and inflammation in both groups.


RESULTS
Median serum FGF21 levels were >15-fold higher in CD patients (3,710.6 ng/l) than in subjects with a GFR >50 ml/min (201.9 ng/l) (P < 0.001). Furthermore, serum creatinine positively and GFR negatively predicted FGF21 concentrations in multiple regression analyses in control subjects (P < 0.05).


CONCLUSIONS
FGF21 serum levels increase in CD patients and are related to markers of renal function in control subjects.
University of Leipzig, Department of Internal Medicine III, Leipzig, Germany.
Sebastian
S
Stein
Anette
A
Bachmann
Ulrike
U
Lössner
Jürgen
J
Kratzsch
Matthias
M
Blüher
Michael
M
Stumvoll
Mathias
M
Fasshauer
D052242:Adiponectin / Q000097:blood; D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism; D003404:Creatinine / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005346:Fibroblast Growth Factors / Q000097:blood*; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000502:physiology*; D007676:Kidney Failure, Chronic / Q000097:blood*; D007677:Kidney Function Tests; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D006435:Renal Dialysis
D052242:Adiponectin; D020738:Leptin; C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors; D002097:C-Reactive Protein; D003404:Creatinine