Lateralization of dynorphin gene expression in the rat striatum.
Hemispheric lateralization is well known in the cerebral cortex, but not in subcortical structures like basal ganglia. The goal of our study was to determine whether lateralization was present in the direct and indirect striatal pathways. We studied gene expression in the striatum of healthy rats, which was divided into two sectors, medial and lateral. Dynorphin (DYN) and enkephalin (ENK) mRNA were analyzed as markers of the direct and indirect striatal pathways, respectively and glutamic acid decarboxylase (GAD) mRNA was analyzed as a marker of all medium spiny neurons. DYN and GAD mRNA expression was higher on the left hemisphere in the medial sector of the striatum, but not in the lateral one. We did not observe any difference between sides with ENK mRNA expression. We suggest the presence of a lateralization in the medial striatum, which is specific for the direct striatal pathway.
Department of Neurology, Inselspital, Bern University Hospital, and University of Bern, 3010 Bern, Switzerland.
Christine
C
Capper-Loup
Alain
A
Kaelin-Lang
D000818:Animals; D003342:Corpus Striatum / Q000166:cytology / Q000378:metabolism*; D004399:Dynorphins / Q000235:genetics / Q000378:metabolism*; D004745:Enkephalins / Q000235:genetics / Q000378:metabolism; D005260:Female; D015870:Gene Expression / Q000502:physiology*; D005968:Glutamate Decarboxylase / Q000235:genetics / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D004745:Enkephalins; D012333:RNA, Messenger; D004399:Dynorphins; D005968:Glutamate Decarboxylase; C402565:glutamate decarboxylase 1