The role of structure activity relationship studies in the search for new GABA uptake inhibitors.
gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian central nervous system (CNS). A decrease in GABAergic neurotransmission seems to be involved in neurological pathologies such as epilepsy, anxiety and pain. This review is focus on structure activity relationship studies aiming the search for new GABA uptake inhibitors.
Kulig
Katarzyna
K
Department of Physicochemical Drug Analysis, Chair of Pharmaceutical Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland. mfkkulig@cyf-kr.edu.pl
Szwaczkiewicz
Marta
M
D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D018756:GABA Antagonists / Q000378:metabolism; D050485:GABA Plasma Membrane Transport Proteins / Q000378:metabolism; D058805:GABA Uptake Inhibitors; D006801:Humans; D020128:Inhibitory Concentration 50; D051379:Mice; D008954:Models, Biological; D008956:Models, Chemical; D018377:Neurotransmitter Agents / Q000378:metabolism; D051381:Rats; D013329:Structure-Activity Relationship; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D018756:GABA Antagonists; D050485:GABA Plasma Membrane Transport Proteins; D058805:GABA Uptake Inhibitors; D018377:Neurotransmitter Agents; D005680:gamma-Aminobutyric Acid