Mesenchymal stem cell-like cells derived from human gastric cancer tissues.
Mesenchymal stem cells (MSCs) have been identified in and isolated from numerous human tissues. The characteristics of mesenchymal stem cells, including their plasticity, the secretion of cytokines, and their low immunogenicity, contribute to their therapeutic potential. It has recently been reported that MSCs are also involved in tumorigenesis and its prognosis. Here, we present the first report of MSC-like cells isolated from human gastric cancer tissues. In our study, gastric cancer-derived MSC-like cells (hGC-MSCs) were isolated from 13 out of 20 cancer tissue samples. Their characteristics, including their morphology, surface antigens, specific gene expression, and differentiation potential, were similar to those of MSCs derived from human bone marrow (hBM-MSCs) but different from gastric cancer cells. The existence of MSC-like cells in gastric cancer tissues suggests that they may be potential targets for cancer therapy and provides an experimental foundation for investigating their role in the initiation and progression of gastric cancers.
Cao
Huiling
H
School of Medical Science and Laboratory Medicine, Key Institute of Clinical Laboratory Science, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu 212001, PR China. chl_208@yahoo.com.cn
Xu
Wenrong
W
Qian
Hui
H
Zhu
Wei
W
Yan
Yongmin
Y
Zhou
Hongxing
H
Zhang
Xu
X
Xu
Xuejing
X
Li
Jigang
J
Chen
Zhong
Z
Xu
Xiaomeng
X
D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology; D017667:Adipocytes / Q000378:metabolism / Q000473:pathology; D000368:Aged; D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D002454:Cell Differentiation; D049109:Cell Proliferation; D005260:Female; D005434:Flow Cytometry; D015870:Gene Expression; D006801:Humans; D008297:Male; D059630:Mesenchymal Stem Cells / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008875:Middle Aged; D010011:Osteocytes / Q000378:metabolism / Q000473:pathology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology*
D012333:RNA, Messenger