In vitro effects of artesunate on the survival of worm pairs and egg production of Schistosoma mansoni.
The effect of artesunate (ART) on the survival time of adult worm pairs of Schistosoma mansoni and on their egg output during in vitro culture was assessed. ART significantly decreased the survival time of both paired male and female worms at concentrations of 5, 10, 20 and 40 mg l- 1 during in vitro cultivation. An inhibitory effect of ART on the daily egg output of paired female worms during in vitro cultivation was also observed.
Department of Parasitology, Institute of Tropical Medicine, Nagasaki University, Sakamoto, Nagasaki, 852-8523 Japan. ymitsui@nagasaki-u.ac.jp
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Mitsui
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Miura
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Aoki
D000818:Animals; D037621:Artemisinins / Q000494:pharmacology*; D000077332:Artesunate; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D010058:Oviposition / Q000187:drug effects*; D010270:Parasite Egg Count / Q000706:statistics & numerical data*; D011897:Random Allocation; D012550:Schistosoma mansoni / Q000187:drug effects*; D012552:Schistosomiasis / Q000188:drug therapy; D012556:Schistosomicides / Q000494:pharmacology*; D012737:Sex Factors; D013997:Time Factors
D037621:Artemisinins; D012556:Schistosomicides; D000077332:Artesunate