Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding.
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D000952:Antigens, Polyomavirus Transforming / Q000378:metabolism*; D002460:Cell Line; D000071877:Checkpoint Kinase 1; D064447:Checkpoint Kinase 2; D004249:DNA Damage; D004260:DNA Repair; D006657:Histones / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D011123:Polyploidy; D011485:Protein Binding; D011494:Protein Kinases / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D013539:Simian virus 40 / Q000472:pathogenicity*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D048868:Adaptor Proteins, Signal Transducing; D000952:Antigens, Polyomavirus Transforming; D006657:Histones; D047908:Intracellular Signaling Peptides and Proteins; D016159:Tumor Suppressor Protein p53; D011494:Protein Kinases; D064447:Checkpoint Kinase 2; C584277:BUB1 protein, human; C090464:Bub1 spindle checkpoint protein; C000605867:CHEK1 protein, human; C578634:CHEK2 protein, human; D000071877:Checkpoint Kinase 1; D017346:Protein Serine-Threonine Kinases