Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells.
D000818:Animals; D055592:Biophysical Phenomena; D002462:Cell Membrane / Q000378:metabolism; D004075:Diglycerides / Q000096:biosynthesis; D007328:Insulin / Q000378:metabolism / Q000494:pharmacology; D055504:Insulin Receptor Substrate Proteins / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology*; D018482:Muscle, Skeletal / Q000201:enzymology* / Q000378:metabolism; D010168:Palmitates / Q000378:metabolism / Q000494:pharmacology; D010766:Phosphorylation; D051381:Rats; D051102:Serine C-Palmitoyltransferase / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction
D004075:Diglycerides; D007328:Insulin; D055504:Insulin Receptor Substrate Proteins; D010168:Palmitates; D051102:Serine C-Palmitoyltransferase