Up-regulation of inflammatory signalings by areca nut extract and role of cyclooxygenase-2 -1195G>a polymorphism reveal risk of oral cancer.
D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D001114:Areca / Q000633:toxicity*; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000235:genetics; D016022:Case-Control Studies; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D051546:Cyclooxygenase 2 / Q000235:genetics*; D016207:Cytokines / Q000235:genetics; D005786:Gene Expression Regulation / Q000187:drug effects*; D005838:Genotype; D055436:Growth Differentiation Factor 15; D006801:Humans; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000209:etiology* / Q000235:genetics; D016328:NF-kappa B / Q000502:physiology; D010936:Plant Extracts / Q000633:toxicity*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D012307:Risk Factors; D015398:Signal Transduction / Q000187:drug effects*; D012907:Smoking / Q000009:adverse effects; D015854:Up-Regulation
D016207:Cytokines; C526140:GDF15 protein, human; D055436:Growth Differentiation Factor 15; D016328:NF-kappa B; D010936:Plant Extracts; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human