The IKK-neutralizing compound Bay11 kills supereffector CD8 T cells by altering caspase-dependent activation-induced cell death.
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000502:physiology*; D053148:Caspase 3 / Q000378:metabolism*; D053181:Caspase 8 / Q000378:metabolism*; D002470:Cell Survival; D002478:Cells, Cultured; D016207:Cytokines / Q000096:biosynthesis; D004789:Enzyme Activation; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D051550:I-kappa B Kinase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000378:metabolism; D009570:Nitriles / Q000494:pharmacology*; D010455:Peptides / Q000494:pharmacology; D010766:Phosphorylation; D053262:Receptors, OX40 / Q000378:metabolism; D013450:Sulfones / Q000494:pharmacology*; D053261:Tumor Necrosis Factor Receptor Superfamily, Member 9 / Q000276:immunology
C434003:3-(4-methylphenylsulfonyl)-2-propenenitrile; D016207:Cytokines; D016328:NF-kappa B; D009570:Nitriles; D010455:Peptides; D053262:Receptors, OX40; D013450:Sulfones; C505717:Tnfrsf4 protein, mouse; D053261:Tumor Necrosis Factor Receptor Superfamily, Member 9; D051550:I-kappa B Kinase; D048049:Extracellular Signal-Regulated MAP Kinases; C505526:Casp8 protein, mouse; D053148:Caspase 3; D053181:Caspase 8