Mechanism of signal transduction in tumor necrosis factor-like weak inducer of apoptosis-induced matrix degradation by MMP-3 upregulation in disc tissues.
D053674:Aggrecans / Q000378:metabolism; D000818:Animals; D000873:Anthracenes / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D001549:Benzamides / Q000494:pharmacology; D000074049:Cytokine TWEAK; D004790:Enzyme Induction; D004791:Enzyme Inhibitors / Q000494:pharmacology; D004797:Enzyme-Linked Immunosorbent Assay; D005109:Extracellular Matrix / Q000187:drug effects* / Q000378:metabolism; D005419:Flavonoids / Q000494:pharmacology; D007124:Immunoenzyme Techniques; D007403:Intervertebral Disc / Q000187:drug effects* / Q000378:metabolism; D019278:Matrix Metalloproteinase 3 / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D011994:Recombinant Proteins / Q000494:pharmacology; D015398:Signal Transduction; D046509:Tissue Culture Techniques; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology; D048069:Tumor Necrosis Factors / Q000378:metabolism* / Q000494:pharmacology; D015854:Up-Regulation
D053674:Aggrecans; D000873:Anthracenes; D001549:Benzamides; D000074049:Cytokine TWEAK; D004791:Enzyme Inhibitors; D005419:Flavonoids; D011994:Recombinant Proteins; C491645:Tnfsf12 protein, mouse; D014409:Tumor Necrosis Factor-alpha; D048069:Tumor Necrosis Factors; C432165:pyrazolanthrone; C492919:N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide; D019278:Matrix Metalloproteinase 3; C093973:2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one