title: Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37.
mesh_terms: D000918:Antibody Specificity; D018797:Cell Cycle Proteins / Q000378:metabolism*; D018833:Chaperonins / Q000378:metabolism*; D051358:Cyclin-Dependent Kinase 4 / Q000378:metabolism; D004789:Enzyme Activation; D045325:HCT116 Cells; D018841:HSP90 Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D009154:Mutation / Q000235:genetics; D009687:Nuclear Proteins / Q000378:metabolism; D010749:Phosphoprotein Phosphatases / Q000378:metabolism; D010766:Phosphorylation; D010768:Phosphoserine / Q000378:metabolism; D011485:Protein Binding; D011494:Protein Kinases / Q000378:metabolism*; D054645:Protein Phosphatase 1 / Q000378:metabolism; D019908:Proto-Oncogene Proteins c-raf / Q000378:metabolism; D012441:Saccharomyces cerevisiae; D013379:Substrate Specificity
chemical_list: C498362:CDC37 protein, human; D018797:Cell Cycle Proteins; D018841:HSP90 Heat-Shock Proteins; D009687:Nuclear Proteins; D010768:Phosphoserine; D011494:Protein Kinases; D019908:Proto-Oncogene Proteins c-raf; D051358:Cyclin-Dependent Kinase 4; D010749:Phosphoprotein Phosphatases; D054645:Protein Phosphatase 1; C089641:protein phosphatase 5; D018833:Chaperonins