Semaphorin 3B inhibits the phosphatidylinositol 3-kinase/Akt pathway through neuropilin-1 in lung and breast cancer cells.
D017209:Apoptosis / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000473:pathology; D053148:Caspase 3 / Q000378:metabolism; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005260:Female; D038362:Glycogen Synthase Kinase 3 / Q000378:metabolism; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008562:Membrane Glycoproteins / Q000032:analysis / Q000494:pharmacology*; D009419:Nerve Tissue Proteins / Q000032:analysis; D039942:Neuropilin-1 / Q000032:analysis / Q000502:physiology*; D000081082:Phosphoinositide-3 Kinase Inhibitors; D010766:Phosphorylation; D051057:Proto-Oncogene Proteins c-akt / Q000037:antagonists & inhibitors*; D011956:Receptors, Cell Surface / Q000032:analysis; D039961:Semaphorins / Q000032:analysis / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects*; D025521:Tumor Suppressor Proteins / Q000494:pharmacology*
D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; C492116:PLXNA1 protein, human; C515995:PLXNA2 protein, human; D000081082:Phosphoinositide-3 Kinase Inhibitors; D011956:Receptors, Cell Surface; C409766:SEMA3B protein, human; D039961:Semaphorins; D025521:Tumor Suppressor Proteins; D039942:Neuropilin-1; C000605506:GSK3B protein, human; D000071679:Glycogen Synthase Kinase 3 beta; D051057:Proto-Oncogene Proteins c-akt; D038362:Glycogen Synthase Kinase 3; D053148:Caspase 3