FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway.
D000130:Achondroplasia / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D001846:Bone Development; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D002454:Cell Differentiation; D002478:Cells, Cultured; D019902:Chondrocytes / Q000378:metabolism; D020219:Chondrogenesis; D006801:Humans; D048369:MAP Kinase Kinase 1 / Q000235:genetics / Q000378:metabolism; D020935:MAP Kinase Signaling System; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D010006:Osteoblasts / Q000378:metabolism; D051498:Receptor, Fibroblast Growth Factor, Type 3 / Q000235:genetics / Q000378:metabolism*; D013796:Thanatophoric Dysplasia / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology
D019485:Bone Morphogenetic Proteins; D051498:Receptor, Fibroblast Growth Factor, Type 3; D048369:MAP Kinase Kinase 1; C482127:Map2k1 protein, mouse