title: Targeting Val 216 in class A beta-lactamases with tricyclic 6-methylidene penems.
mesh_terms: D000929:Antidepressive Agents, Tricyclic / Q000138:chemical synthesis* / Q000737:chemistry; D020134:Catalytic Domain; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D006859:Hydrogen / Q000737:chemistry; D006868:Hydrolysis; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D008958:Models, Molecular; D008968:Molecular Conformation; D012984:Software; D013841:Thiazepines / Q000737:chemistry; D014633:Valine / Q000737:chemistry*; D001618:beta-Lactamases / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000929:Antidepressive Agents, Tricyclic; D013841:Thiazepines; D006859:Hydrogen; D001618:beta-Lactamases; D014633:Valine