Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications.
D059002:Androgen Receptor Antagonists; D018360:Crystallography, X-Ray; D003511:Cyclohexanols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011944:Receptors, Androgen / Q000737:chemistry / Q000378:metabolism; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D013256:Steroids / Q000737:chemistry; D013329:Structure-Activity Relationship
C533184:4-(2-hydroxycyclohexyl)-2-(trifluoromethyl)benzonitrile; D059002:Androgen Receptor Antagonists; D003511:Cyclohexanols; D008024:Ligands; D009570:Nitriles; D017319:Photosensitizing Agents; D011944:Receptors, Androgen; D013256:Steroids