Netrin-1 induces apoptosis in human cervical tumor cells via the TAp73alpha tumor suppressor.
D048868:Adaptor Proteins, Signal Transducing / Q000032:analysis; D017209:Apoptosis; D053148:Caspase 3 / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000494:pharmacology; D000075389:DCC Receptor; D004268:DNA-Binding Proteins / Q000032:analysis / Q000502:physiology*; D005260:Female; D006367:HeLa Cells; D006801:Humans; D009414:Nerve Growth Factors / Q000502:physiology*; D000075388:Netrin-1; D009687:Nuclear Proteins / Q000032:analysis / Q000502:physiology*; D010750:Phosphoproteins / Q000032:analysis; D046988:Proteasome Endopeptidase Complex / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D012097:Repressor Proteins / Q000032:analysis; D015534:Trans-Activators / Q000502:physiology; D014157:Transcription Factors; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53 / Q000502:physiology; D025521:Tumor Suppressor Proteins / Q000032:analysis / Q000502:physiology*; D025801:Ubiquitin / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000032:analysis; D000091102:YAP-Signaling Proteins
D048868:Adaptor Proteins, Signal Transducing; D000075389:DCC Receptor; C501909:DCC protein, human; D004268:DNA-Binding Proteins; C000617351:NTN1 protein, human; D009414:Nerve Growth Factors; D009687:Nuclear Proteins; D010750:Phosphoproteins; D011956:Receptors, Cell Surface; D012097:Repressor Proteins; C115051:TP63 protein, human; C000606460:TP73 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins; D025801:Ubiquitin; D000091102:YAP-Signaling Proteins; C088374:YAP1 protein, human; D000075388:Netrin-1; C432966:ITCH protein, human; D044767:Ubiquitin-Protein Ligases; D053148:Caspase 3; D046988:Proteasome Endopeptidase Complex; D002945:Cisplatin