Brain and eye malformations resembling Walker-Warburg syndrome are recapitulated in mice by dystroglycan deletion in the epiblast.
D000015:Abnormalities, Multiple / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D000818:Animals; D001921:Brain / Q000002:abnormalities* / Q000378:metabolism* / Q000473:pathology; D049030:Dystroglycans / Q000172:deficiency* / Q000235:genetics; D005124:Eye Abnormalities / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005855:Germ Layers / Q000002:abnormalities* / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D006849:Hydrocephalus / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D007223:Infant; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D013577:Syndrome
D049030:Dystroglycans