Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D001522:Behavior, Animal; D015870:Gene Expression; D051379:Mice; D018345:Mice, Knockout; D023421:Models, Animal; D010641:Phenotype; D020033:Protein Isoforms; D012701:Serotonin / Q000032:analysis / Q000096:biosynthesis* / Q000502:physiology; D014018:Tissue Distribution; D014365:Tryptophan Hydroxylase / Q000172:deficiency / Q000235:genetics*
D000928:Antidepressive Agents; D020033:Protein Isoforms; D012701:Serotonin; C487801:Tph1 protein, mouse; C487802:Tph2 protein, mouse; D014365:Tryptophan Hydroxylase