Activated G(alpha)13 impairs cell invasiveness through p190RhoGAP-mediated inhibition of RhoA activity.
D000818:Animals; D045744:Cell Line, Tumor; D054377:Chemokine CXCL12 / Q000494:pharmacology; D044365:GTP-Binding Protein alpha Subunits, G12-G13 / Q000502:physiology*; D019206:GTP-Binding Protein alpha Subunits, Gi-Go / Q000502:physiology; D020662:Guanine Nucleotide Exchange Factors / Q000502:physiology*; D006801:Humans; D008175:Lung Neoplasms / Q000517:prevention & control / Q000556:secondary; D008244:Lysophosphatidylcholines / Q000494:pharmacology; D008545:Melanoma / Q000473:pathology* / Q000556:secondary; D051379:Mice; D016513:Mice, SCID; D009361:Neoplasm Invasiveness; D051567:Proto-Oncogene Proteins c-vav / Q000378:metabolism; D012097:Repressor Proteins / Q000502:physiology*; D015398:Signal Transduction; D041701:Swiss 3T3 Cells; D013928:Thromboxane A2 / Q000502:physiology; D020742:rhoA GTP-Binding Protein / Q000037:antagonists & inhibitors* / Q000502:physiology
C074560:ARHGAP35 protein, human; D054377:Chemokine CXCL12; D020662:Guanine Nucleotide Exchange Factors; D008244:Lysophosphatidylcholines; D051567:Proto-Oncogene Proteins c-vav; D012097:Repressor Proteins; C093651:VAV2 protein, human; D013928:Thromboxane A2; D044365:GTP-Binding Protein alpha Subunits, G12-G13; D019206:GTP-Binding Protein alpha Subunits, Gi-Go; D020742:rhoA GTP-Binding Protein