CRAF autophosphorylation of serine 621 is required to prevent its proteasome-mediated degradation.
D000818:Animals; D004789:Enzyme Activation; D004795:Enzyme Stability; D005347:Fibroblasts / Q000201:enzymology; D051379:Mice; D008954:Models, Biological; D010641:Phenotype; D010766:Phosphorylation; D010768:Phosphoserine / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D017510:Protein Folding; D011499:Protein Processing, Post-Translational; D019908:Proto-Oncogene Proteins c-raf / Q000378:metabolism*; D054875:Ubiquitination
D010768:Phosphoserine; D019908:Proto-Oncogene Proteins c-raf; D046988:Proteasome Endopeptidase Complex