Ductal injection of JNK inhibitors before pancreas preservation prevents islet apoptosis and improves islet graft function.
D000818:Animals; D017209:Apoptosis; D003921:Diabetes Mellitus, Experimental / Q000517:prevention & control; D004791:Enzyme Inhibitors / Q000008:administration & dosage* / Q000627:therapeutic use; D006085:Graft Survival / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007515:Islets of Langerhans / Q000166:cytology / Q000187:drug effects; D016381:Islets of Langerhans Transplantation / Q000502:physiology; D048031:JNK Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors*; D051379:Mice; D008819:Mice, Nude; D009926:Organ Preservation; D019188:Organ Preservation Solutions / Q000008:administration & dosage*; D010179:Pancreas / Q000166:cytology / Q000187:drug effects* / Q000601:surgery; D013552:Swine; D020858:Tissue and Organ Harvesting
D004791:Enzyme Inhibitors; D019188:Organ Preservation Solutions; D048031:JNK Mitogen-Activated Protein Kinases