Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction.
D002460:Cell Line; D018076:DNA, Complementary / Q000235:genetics; D006801:Humans; D051550:I-kappa B Kinase / Q000378:metabolism*; D050839:Interferon Regulatory Factor-7 / Q000378:metabolism; D016898:Interferon-alpha / Q000096:biosynthesis* / Q000235:genetics; D053594:Myeloid Differentiation Factor 88 / Q000378:metabolism; D010750:Phosphoproteins / Q000378:metabolism*; D010766:Phosphorylation; D011485:Protein Binding; D015398:Signal Transduction; D013379:Substrate Specificity; D051199:Toll-Like Receptor 7 / Q000378:metabolism*; D051217:Toll-Like Receptor 9 / Q000378:metabolism*; D014764:Viral Proteins / Q000378:metabolism*
D018076:DNA, Complementary; C494234:IRF7 protein, human; D050839:Interferon Regulatory Factor-7; D016898:Interferon-alpha; D053594:Myeloid Differentiation Factor 88; D010750:Phosphoproteins; C495348:TLR7 protein, human; D051199:Toll-Like Receptor 7; D051217:Toll-Like Receptor 9; C069181:V protein, measles virus; D014764:Viral Proteins; D051550:I-kappa B Kinase