Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001549:Benzamides / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003598:Cytoskeletal Proteins; D005260:Female; D006801:Humans; D007211:Indoles; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D008938:Mitosis / Q000187:drug effects*; D000072379:NIMA-Related Kinases; D009368:Neoplasm Transplantation; D009687:Nuclear Proteins / Q000037:antagonists & inhibitors*; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors*; D015398:Signal Transduction / Q000187:drug effects; D013844:Thiazoles / Q000494:pharmacology* / Q000627:therapeutic use; D014183:Transplantation, Heterologous; D014631:Valerates
D000970:Antineoplastic Agents; D001549:Benzamides; D003598:Cytoskeletal Proteins; D007211:Indoles; C120529:NDC80 protein, human; D009687:Nuclear Proteins; D013844:Thiazoles; D014631:Valerates; C510545:methyl 5-(5,6-dichloro-2-indolyl)-2-methoxy-2,4-pentadienoate; C089441:NEK2 protein, human; D000072379:NIMA-Related Kinases; D017346:Protein Serine-Threonine Kinases