Transition-metal-free indirect friedlander synthesis of quinolines from alcohols.
The synthesis of polysubstituted quinolines can be easily and greenly accomplished by the direct reaction between the corresponding 2-aminobenzylic alcohol derivative and either a ketone or alcohol in the presence of a base, without any transition-metal catalyst.
Martínez
Ricardo
R
Instituto de Síntesis Orgánica and Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Alicante, Apdo. 99, E-03080-Alicante, Spain.
Ramón
Diego J
DJ
Yus
Miguel
M
D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis; D007202:Indicators and Reagents; D007211:Indoles / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D017553:Phosphorus Compounds / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis*; D021241:Spectrometry, Mass, Electrospray Ionization
D006571:Heterocyclic Compounds; D007202:Indicators and Reagents; D007211:Indoles; D017553:Phosphorus Compounds; D011804:Quinolines