Genotypic versus phenotypic characterization, with respect to beta-lactam susceptibility, of Haemophilus influenzae isolates exhibiting decreased susceptibility to beta-lactam resistance markers.
Among 165 Spanish Haemophilus influenzae isolates with mutations in the ftsI gene (ftsI(+)) (2005 to 2007), 73% were beta-lactamase negative and 26.7% were positive. The proportion of beta-lactamase-negative isolates to beta-lactamase-positive isolates was 2:1 to 4:1 in general, versus 1:3 in pediatric hospitals. Among 44 beta-lactamase-positive strains, 8 strains produced ROB-1 (5 from the pediatric hospital). beta-Lactamase-positive ftsI(+) strains were phylogenetically closer than were beta-lactamase-negative strains.
Sevillano
David
D
Microbiology Department, School of Medicine, Univ Complutense, Madrid, Spain.
Giménez
María-José
MJ
Cercenado
Emilia
E
Cafini
Fabio
F
Gené
Amadeo
A
Alou
Luis
L
Marco
Francesc
F
Martínez-Martínez
Luis
L
Coronel
Pilar
P
Aguilar
Lorenzo
L
D001426:Bacterial Proteins / Q000145:classification / Q000235:genetics; D005838:Genotype; D006193:Haemophilus influenzae / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008826:Microbial Sensitivity Tests; D009154:Mutation; D010641:Phenotype; D018440:beta-Lactam Resistance / Q000235:genetics*; D047090:beta-Lactams / Q000494:pharmacology
D001426:Bacterial Proteins; D047090:beta-Lactams