title: Coordinated protein sorting, targeting and distribution in polarized cells.
abstract: The polarized distribution of functions in polarized cells requires the coordinated interaction of three machineries that modify the basic mechanisms of intracellular protein trafficking and distribution. First, intrinsic protein-sorting signals and cellular decoding machineries regulate protein trafficking to plasma membrane domains; second, intracellular signalling complexes define the plasma membrane domains to which proteins are delivered; and third, proteins that are involved in cell-cell and cell-substrate adhesion orientate the three-dimensional distribution of intracellular signalling complexes and, accordingly, the direction of membrane traffic. The integration of these mechanisms into a complex and dynamic network is crucial for normal tissue function and is often defective in disease states.
authors.affiliation: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA. mellman.ira@gene.com
authors.forename: Ira
authors.initials: I
authors.lastname: Mellman
authors.forename: W James
authors.initials: WJ
authors.lastname: Nelson
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000737:chemistry; D016764:Cell Polarity; D003599:Cytoskeleton / Q000378:metabolism; D006801:Humans; D038081:Organogenesis; D010336:Pathology; D021381:Protein Transport; D011506:Proteins / Q000032:analysis / Q000378:metabolism
chemical_list: D011506:Proteins