Decarboxylative biaryl synthesis from aromatic carboxylates and aryl triflates.
A new catalyst system, generated in situ from Cu2O, 1,10-phenanthroline, PdI2, and Tol-BINAP, for the first time allows the decarboxylative coupling of carboxylic acids with aryl triflates. In contrast to previous decarboxylative couplings that remained limited to certain activated carboxylates, e.g., ortho-substituted benzoates, this halide-free protocol is generally applicable to aromatic carboxylic acid salts regardless of their substitution pattern.
Goossen
Lukas J
LJ
FB Chemie-Organische Chemie, TU Kaiserslautern, Erwin-Schroedinger-Strasse, Geb. 54, 67663 Kaiserslautern, Germany. goossen@chemie.uni-kl.de
Rodríguez
Nuria
N
Linder
Christophe
C