title: Regulated adhesion as a driving force of gastrulation movements.
abstract: Recent data have reinforced the fundamental role of regulated cell adhesion as a force that drives morphogenesis during gastrulation. As we discuss, cell adhesion is required for all modes of gastrulation movements in all organisms. It can even be instructive in nature, but it must be tightly and dynamically regulated. The picture that emerges from the recent findings that we review here is that different modes of gastrulation movements use the same principles of adhesion regulation, while adhesion molecules themselves coordinate the intra- and extracellular changes required for directed cell locomotion.
authors.affiliation: Max-Planck Institute of Immunobiology, D-79108 Freiburg, Germany. mhammers@uni-koeln.de
authors.forename: Matthias
authors.initials: M
authors.lastname: Hammerschmidt
authors.forename: Doris
authors.initials: D
authors.lastname: Wedlich
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000378:metabolism; D054262:Gastrulation; D018507:Gene Expression Regulation, Developmental; D008954:Models, Biological
chemical_list: D015815:Cell Adhesion Molecules