A ubiquitin-like protein unleashes ubiquitin ligases.
Modification of cullin-RING ubiquitin ligases by the ubiquitin-like molecule Nedd8 promotes substrate ubiquitination. A crystal structure of a cullin modified by Nedd8 recently reported in Cell (Duda et al., 2008) and a biochemical study in Molecular Cell (Saha and Deshaies, 2008) reveal the dramatic impact on the ligase machinery by conjugation of ubiquitin or ubiquitin-like proteins.
Saifee
Nabiha Huq
NH
Department of Pharmacology, Box 357280, University of Washington, Seattle, WA 98195, USA.
Zheng
Ning
N
D018360:Crystallography, X-Ray; D044842:Cullin Proteins / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D000075687:NEDD8 Protein; D017434:Protein Structure, Tertiary; D025801:Ubiquitin / Q000378:metabolism; D043743:Ubiquitin-Protein Ligase Complexes / Q000378:metabolism*; D014452:Ubiquitins / Q000737:chemistry* / Q000378:metabolism
D044842:Cullin Proteins; D000075687:NEDD8 Protein; C082860:NEDD8 protein, human; D025801:Ubiquitin; D014452:Ubiquitins; D043743:Ubiquitin-Protein Ligase Complexes