title: Clinical assessment of a nasal decongestion test by visual analog scale in allergic rhinitis.
abstract: BACKGROUND
  Nasal airflow, as measured by rhinomanometry, is frequently impaired in allergic rhinitis (AR). The decongestion test evaluates whether the application of an intranasal vasoconstrictor drug increases nasal airflow. That allergy is characterized by inflammation and that the response to the decongestion test correlates with the grade of inflammatory reaction has previously been shown. The aim of this study was to verify the suitability of the use of the visual analog scales (VASs) as a surrogate for rhinomanometry in the decongestion test assessment in patients with persistent allergic rhinitis.
  
  
  METHODS
  One hundred three patients (mean age, 23 years [2.24 SD]) were studied. Nasal symptoms, VAS, rhinomanometry, and nasal decongestion test were assessed in all patients.
  
  
  RESULTS
  A significant association was observed between VAS and nasal airflow after the decongestion test (Spearman R = -33.3%; p < 0.001). Moreover, a significant inverse association between changes in decongestion measures was detected, with a Spearman R = -64.7% (p < 0.001). The associated sensitivity was of 92.5%, and the specificity for this test was 60.0%. The corresponding area under the receiver operating characteristic curve was 0.81.
  
  
  CONCLUSIONS
  The use of VAS for assessing the decongestion test appears clinically relevant in that it allows, with a fair degree of reliability, such a test to be performed in the absence of rhinomanometry.
authors.affiliation: Azienda Ospedaliera Universitaria San Martino, Genoa, Italy. gio.cip@libero.it
authors.forename: Giorgio
authors.initials: G
authors.lastname: Ciprandi
authors.forename: Catherine
authors.initials: C
authors.lastname: Klersy
authors.forename: Franco
authors.initials: F
authors.lastname: Ameli
authors.forename: Ignazio
authors.initials: I
authors.lastname: Cirillo
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D005500:Follow-Up Studies; D006801:Humans; D014663:Nasal Decongestants / Q000008:administration & dosage; D015508:Nasal Obstruction / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D011446:Prospective Studies; D012123:Pulmonary Ventilation / Q000502:physiology*; D015203:Reproducibility of Results; D012221:Rhinitis, Allergic, Perennial / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D025363:Rhinomanometry; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
chemical_list: D014663:Nasal Decongestants