MYC and gastric adenocarcinoma carcinogenesis.
MYC is an oncogene involved in cell cycle regulation, cell growth arrest, cell adhesion, metabolism, ribosome biogenesis, protein synthesis, and mitochondrial function. It has been described as a key element of several carcinogenesis processes in humans. Many studies have shown an association between MYC deregulation and gastric cancer. MYC deregulation is also seen in gastric preneoplastic lesions and thus it may have a role in early gastric carcinogenesis. Several studies have suggested that amplification is the main mechanism of MYC deregulation in gastric cancer. In the present review, we focus on the deregulation of the MYC oncogene in gastric adenocarcinoma carcinogenesis, including its association with Helicobacter pylori (H pylori) and clinical applications.
Calcagno
Danielle-Queiroz
DQ
Departamento de Biologia, Instituto de Ciencias Biologicas, Campus Universitario do Guama/Universidade Federal do Para, Av. Augusto Correa 01, Belem, PA 66075-900, Brazil.
Leal
Mariana-Ferreira
MF
Assumpcao
Paulo-Pimentel
PP
Smith
Marilia-Arruda-Cardoso
MA
Burbano
Rommel-Rodriguez
RR
D000230:Adenocarcinoma / Q000235:genetics* / Q000382:microbiology; D002471:Cell Transformation, Neoplastic; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D016259:Genes, myc / Q000235:genetics* / Q000502:physiology; D016480:Helicobacter pylori / Q000502:physiology; D006801:Humans; D013274:Stomach Neoplasms / Q000235:genetics* / Q000382:microbiology