title: [New therapeutic alternatives in migraine prophylaxis using histamine H3 receptor agonists].
abstract: BACKGROUND
  Subcutaneous histamine at low concentrations interacts with H3-receptors and may constitute a new therapeutic drug in migraine prophylaxis. It acts by limiting the excessive inflammatory response involved in migraine pathophysiology.
  
  
  OBJECTIVE
  Describe the results of a 15-year trial administering histamine at low concentrations.
  
  
  METHODS
  Different study designs were used with subcutaneous histamine (10 microg/ml in Evan's solution) twice weekly, with an initial administration of microg (0.1 ml) and gradually increasing the dose to 10 microg (1.0 ml) over a 12-week period together with placebo, sodium valproate and topiramate. A Friedman-type rank ANOVA test was used to assess the difference between basal values and different design outcomes.
  
  
  RESULTS
  Data recorded during the 12-week period showed a significant reduction in variables from both treatment groups (histamine) compared with basaline stage results (p < 0.001). The histamine group reported a reduction of headache frequency (50%), decrease in pain intensity (51%), length of migraine attacks (45%) and painkiller use (52%).
  
  
  CONCLUSIONS
  The present study provides evidence on the safety and efficiency of subcutaneous histamine administered at a dose of 1-10 microg twice weekly. This treatment constitutes a new therapeutic alternative, and provides a clinical and pharmacological basis for the use of H3 histaminergic agonists in migraine prophylaxis.
authors.affiliation: Unidad de Investigación en Epidemiología Clínica, Hospital General de Zona 1, Instituto Mexicano del Seguro Social, Colima, Col. millanrebeca@hotmail.com
authors.forename: Rebeca O
authors.initials: RO
authors.lastname: Millán-Guerrero
authors.forename: Rebeca
authors.initials: R
authors.lastname: Isais-Millán
mesh_terms: D000328:Adult; D005260:Female; D017442:Histamine Agonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000517:prevention & control*
chemical_list: D017442:Histamine Agonists