Massively parallel production of lipid microstructures.
In this paper we describe a simple and inexpensive microfluidic system for the production of lipid tubules and vesicles. The system incorporates a central microporous membrane for interfacing lipid films with aqueous flows. Hydrodynamic drag was used for the parallel elongation of high axial ratio lipid tubules with uniform 1.5 +/- 0.5 microm diameters. Alternatively, electrokinetic operation was used for the rapid and continuous production of vast numbers of lipid vesicles with diameters ranging from 1 to 3 microm.
West
Jonathan
J
Institute for Analytical Sciences, Bunsen-Kirchhoff-Str. 11, D-44139, Dortmund, Germany.
Manz
Andreas
A
Dittrich
Petra S
PS
D003365:Costs and Cost Analysis; D007700:Kinetics; D008055:Lipids / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D044085:Microfluidics / Q000191:economics / Q000379:methods*; D008853:Microscopy; D016062:Porosity
D008055:Lipids; D008081:Liposomes