[Survivin, the starlet of the passenger-protein complex : check-up for its tenth anniversary].
Ten year after its discovery Survivin has gained a strategic place within the chromosomal passenger complex. Whereas INCENP, Borealin and Aurora B are fully immobile in the complex, Survivin is mobile on centromere. Its mobility is regulated both by phosphorylation and ubiquitination. Survivin is a dynamic messenger that senses the central spindle tension and participates to the control of the mitotic chekpoint. In this review, we have detailed the multiple mitotic activities of Survivin and discussed them in light of the recent reported crystallographic data.
Delacour-Larose
Marlène
M
Inserm U823, Institut Albert Bonniot, Université Joseph Fourier, Domaine de la Merci, 38706 La Tronche Cedex, France. marlene.delacour@ujf-grenoble.fr
Hoang
Thi My Nhung
TM
Molla
Annie
A
D064107:Aurora Kinase B; D064127:Aurora Kinases; D018797:Cell Cycle Proteins / Q000502:physiology*; D002470:Cell Survival; D002503:Centromere / Q000502:physiology; D002868:Chromosomal Proteins, Non-Histone / Q000502:physiology*; D003599:Cytoskeleton / Q000502:physiology / Q000648:ultrastructure; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins / Q000502:physiology*; D008870:Microtubules / Q000502:physiology / Q000648:ultrastructure; D008938:Mitosis / Q000502:physiology*; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D008941:Spindle Apparatus / Q000502:physiology; D000077022:Survivin; D054875:Ubiquitination
C107489:BIRC5 protein, human; C490157:CDCA8 protein, human; D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; C083767:INCENP protein, human; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D000077022:Survivin; C576921:AURKB protein, human; D064107:Aurora Kinase B; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases