title: Insulin resistance, serum adiponectin, and proinflammatory markers in young subjects with the metabolic syndrome.
abstract: Insulin resistance is the underlying metabolic abnormality in the metabolic syndrome. The low-grade chronic inflammation may be associated with metabolic risk factors and atherogenesis. The aim of our study was to establish the link between the metabolic syndrome, as defined by the National Cholesterol Education Program (NCEP) criteria, and insulin sensitivity, serum adiponectin, and parameters of chronic inflammation in young subjects. The group of 223 subjects (mean age, 25.86 +/- 5.49 years; body mass index, 28.04 +/- 6.91 kg/m2) was studied. Oral glucose tolerance test, euglycemic hyperinsulinemic clamp, and estimation of serum adiponectin and proinflammatory factors were performed. The NCEP-defined metabolic syndrome was present in 49 subjects (21.97%). The higher the number of NCEP criteria fulfilled was, the bigger were the decrease in insulin sensitivity (P < .0001) and adiponectin (P < .0001) and the increase in fasting and postload insulin (both Ps < .0001), C-reactive protein (P < .0001), interleukin 18 (P < .0001), interleukin 6 (P < .0001), and soluble tumor necrosis factor-alpha receptors sTNFR1 (P < .0001) and sTNFR2 (P < .0001) observed. Multiple regression analysis revealed that adiponectin and inflammatory factors predicted NCEP score independent of insulin sensitivity (all adjusted beta values between .16 and .32, all Ps < .01). Young subjects with metabolic syndrome demonstrate an increased inflammatory response and lower adiponectin concentration.
authors.affiliation: Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, 15-276 Białystok, Poland. irinak@poczta.onet.pl
authors.forename: Irina
authors.initials: I
authors.lastname: Kowalska
authors.forename: Marek
authors.initials: M
authors.lastname: Straczkowski
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Nikolajuk
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Adamska
authors.forename: Monika
authors.initials: M
authors.lastname: Karczewska-Kupczewska
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Otziomek
authors.forename: Ida
authors.initials: I
authors.lastname: Kinalska
authors.forename: Maria
authors.initials: M
authors.lastname: Gorska
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications*; D007333:Insulin Resistance; D020382:Interleukin-18 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology / Q000276:immunology / Q000378:metabolism*; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000097:blood; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000097:blood; D012044:Regression Analysis
chemical_list: D052242:Adiponectin; D005230:Fatty Acids, Nonesterified; D020382:Interleukin-18; D015850:Interleukin-6; D047888:Receptors, Tumor Necrosis Factor, Type I; D047889:Receptors, Tumor Necrosis Factor, Type II; D002097:C-Reactive Protein