title: The effects of BADGE and caffeine on the time-course response of adiponectin and lipid oxidative enzymes in high fat diet-fed C57BL/6J mice: correlation with reduced adiposity and steatosis.
abstract: Adiponectin, which is expressed exclusively in adipose tissue, has been shown to increase fatty acid oxidation via activation of AMP-activated kinase (AMPK) and phosphorylation of acetyl CoA carboxylase (ACC). ACC phosphorylation and carnitine palmitoyl-transferase-1 (CPT1) activity have been shown to be rate controlling factors in fatty acid oxidation. In high fat diet (HFD)-induced obese mice, we analyzed the time-course of changes in the expression of adiponectin and lipid oxidative enzymes induced by treatment with bisphenol A diglycidyl ether (BADGE) or caffeine for 8 weeks, and investigated whether the changes of adiponectin and lipid oxidative enzymes expression correlated with reduced adiposity or steatosis after 8 weeks of treatment. After 8 weeks of treatment, BADGE and caffeine had reduced body weight and epididymal adipose tissue weight in mice fed HFD, and markedly reduced the number of fatty droplets in the liver. Interestingly, the expression of adiponectin and lipid oxidative enzymes significantly increased after 2 weeks of treatment. These results indicate that the expression of adiponectin and lipid oxidative enzymes in the early stages of BADGE or caffeine treatment correlated well with the long-term anti-obesity effects.
authors.affiliation: Amorepacific Corporation R&D Center, Daegu, Korea.
authors.forename: Jun-Won
authors.initials: JW
authors.lastname: Yun
authors.forename: Eui-Seok
authors.initials: ES
authors.lastname: Shin
authors.forename: Si-Young
authors.initials: SY
authors.lastname: Cho
authors.forename: Shin-Hyoung
authors.initials: SH
authors.lastname: Kim
authors.forename: Chae-Wook
authors.initials: CW
authors.lastname: Kim
authors.forename: Tae-Ryong
authors.initials: TR
authors.lastname: Lee
authors.forename: Bae-Hwan
authors.initials: BH
authors.lastname: Kim
mesh_terms: D000103:Acetyl-CoA Carboxylase / Q000378:metabolism*; D052242:Adiponectin / Q000032:analysis*; D000818:Animals; D001713:Biphenyl Compounds / Q000494:pharmacology*; D002110:Caffeine / Q000494:pharmacology*; D002334:Carnitine O-Palmitoyltransferase / Q000378:metabolism*; D004041:Dietary Fats / Q000008:administration & dosage*; D005234:Fatty Liver / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000378:metabolism*; D013997:Time Factors
chemical_list: D052242:Adiponectin; D001713:Biphenyl Compounds; D004041:Dietary Fats; D002110:Caffeine; D002334:Carnitine O-Palmitoyltransferase; D000103:Acetyl-CoA Carboxylase