title: Fronto-limbic circuitry in euthymic bipolar disorder: evidence for prefrontal hyperactivation.
abstract: Functional magnetic resonance imaging (fMRI) studies of bipolar disorder have revealed fronto-limbic abnormalities in patients during manic and depressive episodes. However, relatively few studies have examined neural activity during euthymia, leaving unanswered questions concerning the impact of mood state on activity in these brain regions. In the present study, we examined 15 remitted bipolar type I patients and 16 demographically matched healthy comparison subjects during performance on an affective face-matching task previously shown to elicit amygdala hyperactivation and prefrontal hypoactivation in manic relative to healthy subjects. In our euthymic sample, amygdala activation did not differ from controls. However, bipolar patients showed hyperactivation in inferior prefrontal cortical regions compared with controls, a finding that contrasts with the hypoactivation previously reported in this region in manic patients. Given the reciprocal relationship between the prefrontal cortex and limbic structures, we propose state-related amygdala activity, similar to that of healthy controls, may be associated with prefrontal hyperactivation when bipolar patients are asymptomatic.
authors.affiliation: Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Robinson
authors.forename: E Serap
authors.initials: ES
authors.lastname: Monkul
authors.forename: Diana
authors.initials: D
authors.lastname: Tordesillas-Gutiérrez
authors.forename: Crystal
authors.initials: C
authors.lastname: Franklin
authors.forename: Carrie E
authors.initials: CE
authors.lastname: Bearden
authors.forename: Peter T
authors.initials: PT
authors.lastname: Fox
authors.forename: David C
authors.initials: DC
authors.lastname: Glahn
mesh_terms: D000328:Adult; D000679:Amygdala / Q000378:metabolism / Q000503:physiopathology; D001714:Bipolar Disorder / Q000378:metabolism* / Q000503:physiopathology*; D005260:Female; D005625:Frontal Lobe / Q000378:metabolism* / Q000503:physiopathology*; D006801:Humans; D008032:Limbic System / Q000378:metabolism* / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net / Q000378:metabolism* / Q000503:physiopathology*; D017397:Prefrontal Cortex / Q000378:metabolism* / Q000503:physiopathology*