Synthesis of biodegradable poly-epsilon-caprolactone microspheres by dispersion ring-opening polymerization in supercritical carbon dioxide.
A series of fluorinated diblock and triblock copolymers of poly(epsilon-caprolactone) and poly(heptadecafluorodecylacrylate) were prepared by combining ring-opening polymerization of epsilon-CL and atom transfer radical polymerization of the acrylate. These copolymers with well-controlled molecular weight and composition were characterized by (1)H NMR spectroscopy and used as stabilizers for the dispersion ring-opening polymerization of epsilon-CL in supercritical carbon dioxide. The effect of composition and architecture of the polymeric stabilizers on the stabilization of PCL microspheres was investigated. Finally, purification of PCL was successfully implemented by reactive supercritical fluid extraction of the tin catalyst.
Grignard
Bruno
B
Center for Education and Research on Macromolecules, University of Liege, Sart Tilman B6,4000 Liège, Belgium.
Stassin
Fabrice
F
Calberg
Cédric
C
Jérôme
Robert
R
Jérôme
Christine
C
D000180:Acrylic Resins; D002245:Carbon Dioxide; D005079:Excipients; D008863:Microspheres; D011091:Polyesters / Q000138:chemical synthesis*
D000180:Acrylic Resins; D005079:Excipients; D011091:Polyesters; D002245:Carbon Dioxide; C016240:polycaprolactone; C006903:carbopol 940