Spectacular induced-fit process for guest binding by a calix[6]arene Zn(II) funnel complex.
The host properties of a calix[6]arene cone capped by a Zn(II) tris-imidazole core at the small rim and decorated by three NH(2) substituents at the large rim are described and compared to the hexa-tBu parent complex. It is shown that the replacement of three bulky tBu substituents by three hydrophilic and small NH(2) groups has three major impacts: the receptor is now soluble in aqueous media, it accepts large guests such as dimethyldopamine and, most interestingly, undergoes a spectacular induced-fit behavior for guest binding.
Coquière
David
D
Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR CNRS 8601, Université Paris Descartes, 45 rue des Saints-Pères, 75006 Paris, France.
Marrot
Jérôme
J
Reinaud
Olivia
O