title: Synthetic studies of heterocyclic natural products.
abstract: Recent reports of the syntheses of heterocyclic natural products that are isolated from bacteria, fungi, plants and marine sources are discussed. This review emphasizes new developments in synthetic methodology and strategies for such products, and the potential biological activity of the metabolites that are described is highlighted. Concepts of conformational analysis, stereoelectronic control and reaction mechanism are all used in the development of new methodology. Despite the variety and scope of synthetic efforts, the synthesis of new organic molecules and the improved synthesis of known molecules remains a major task for organic chemists.
authors.affiliation: University of Pennsylvania, Department of Chemistry, 231 South 34th Street, Philadelphia, PA 19104, USA. mjoullie@sas.upenn.edu
authors.forename: Madeleine M
authors.initials: MM
authors.lastname: Joullié
authors.forename: Simon
authors.initials: S
authors.lastname: Berritt
authors.forename: Erin M
authors.initials: EM
authors.lastname: Forbeck
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis*; D055808:Drug Discovery; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D001688:Biological Products; D006571:Heterocyclic Compounds