title: tRNAdb 2009: compilation of tRNA sequences and tRNA genes.
abstract: One of the first specialized collections of nucleic acid sequences in life sciences was the 'compilation of tRNA sequences and sequences of tRNA genes' (http://www.trna.uni-bayreuth.de). Here, an updated and completely restructured version of this compilation is presented (http://trnadb.bioinf.uni-leipzig.de). The new database, tRNAdb, is hosted and maintained in cooperation between the universities of Leipzig, Marburg, and Strasbourg. Reimplemented as a relational database, tRNAdb will be updated periodically and is searchable in a highly flexible and user-friendly way. Currently, it contains more than 12 000 tRNA genes, classified into families according to amino acid specificity. Furthermore, the implementation of the NCBI taxonomy tree facilitates phylogeny-related queries. The database provides various services including graphical representations of tRNA secondary structures, a customizable output of aligned or un-aligned sequences with a variety of individual and combinable search criteria, as well as the construction of consensus sequences for any selected set of tRNAs.
authors.affiliation: Bioinformatics Group, Department of Computer Science and Interdisciplinary Center for Bioinformatics, University of Leipzig, Härtelstrasse 16-18, D-04107 Leipzig, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Jühling
authors.forename: Mario
authors.initials: M
authors.lastname: Mörl
authors.forename: Roland K
authors.initials: RK
authors.lastname: Hartmann
authors.forename: Mathias
authors.initials: M
authors.lastname: Sprinzl
authors.forename: Peter F
authors.initials: PF
authors.lastname: Stadler
authors.forename: Joern
authors.initials: J
authors.lastname: Pütz
mesh_terms: D030561:Databases, Nucleic Acid; D010802:Phylogeny; D012343:RNA, Transfer / Q000737:chemistry* / Q000145:classification / Q000235:genetics*; D017422:Sequence Analysis, DNA; D017423:Sequence Analysis, RNA; D012984:Software
chemical_list: D012343:RNA, Transfer