title: Formulation of current density weighted indices for correspondence between functional MRI and electrocortical stimulation maps.
abstract: OBJECTIVE
  Accurate localization of functionally significant brain regions reduces risks of post-operative neurological deficits. The gold standard for presurgical brain mapping is subdural electrocortical stimulation (ECS), which is an open-cranium surgical procedure. Functional MRI (fMRI) may be a noninvasive alternative if it can be shown that fMRI and ECS maps are spatially consistent. We formulate new 3D current density weighted ECS-fMRI correspondence indices and illustrate their use on human data.
  
  
  METHODS
  Current density maps were computed for simulated and human datasets by solving the electrostatic Laplace equation. The proposed indices were characterized and compared with fixed radii and Euclidean distance indices.
  
  
  RESULTS
  Results from simulated datasets showed that the proposed indices quantify correspondence between fMRI and the ECS truth predictably, and provide conspicuous sensitivity increase from fixed radii indices, whereas Euclidean distances may not be suitable measures of the correspondence.
  
  
  CONCLUSIONS
  The proposed indices reflect contextual information from surrounding electrodes and may be physiologically more meaningful in evaluating ECS-fMRI correspondence.
  
  
  CONCLUSIONS
  To identify safe limits of resection, an ECS map requires placement of electrodes on a patient's brain. Our proposed indices accurately quantify ECS-fMRI correspondence and may be used to evaluate fMRI as a noninvasive alternative for defining resection limits.
authors.affiliation: Department of Radiology, University of Michigan Medical School, 109 Zina Pitcher Place, AC51 BSRB, Ann Arbor, MI 48109-2200, USA.
authors.forename: Desmond T B
authors.initials: DT
authors.lastname: Yeo
authors.forename: Charles R
authors.initials: CR
authors.lastname: Meyer
authors.forename: Jack M
authors.initials: JM
authors.lastname: Parent
authors.forename: Daniela N
authors.initials: DN
authors.lastname: Minecan
authors.forename: Oren
authors.initials: O
authors.lastname: Sagher
authors.forename: Karen J
authors.initials: KJ
authors.lastname: Kluin
authors.forename: Boklye
authors.initials: B
authors.lastname: Kim
mesh_terms: D001931:Brain Mapping; D002540:Cerebral Cortex / Q000098:blood supply* / Q000502:physiology*; D004558:Electric Stimulation / Q000379:methods*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D009716:Numerical Analysis, Computer-Assisted; D010100:Oxygen / Q000097:blood
chemical_list: D010100:Oxygen