title: Antifungal susceptibilities among different serotypes of Cryptococcus gattii and Cryptococcus neoformans.
abstract: We measured antifungal activity against 128 cryptococcal isolates (86 of C. neoformans and 42 of C. gattii) to determine if differences in serotype susceptibility exist. Contrary to previous results, we found no serotype susceptibility differences. Isavuconazole, posaconazole, and voriconazole demonstrated excellent potency against each isolate and serotype, including isolates with reduced fluconazole susceptibilities.
authors.affiliation: Department of Internal Medicine, Division of Infectious Diseases,University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA. thompsong2@uthscsa.edu
authors.forename: George R
authors.initials: GR
authors.lastname: Thompson
authors.forename: Nathan P
authors.initials: NP
authors.lastname: Wiederhold
authors.forename: Annette W
authors.initials: AW
authors.lastname: Fothergill
authors.forename: Ana C
authors.initials: AC
authors.lastname: Vallor
authors.forename: Brian L
authors.initials: BL
authors.lastname: Wickes
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Patterson
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D003454:Cryptococcus / Q000145:classification / Q000187:drug effects*; D003455:Cryptococcus neoformans / Q000145:classification / Q000187:drug effects*; D015725:Fluconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009570:Nitriles / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology; D012703:Serotyping; D014230:Triazoles / Q000494:pharmacology; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D009570:Nitriles; D011725:Pyridines; D011743:Pyrimidines; D014230:Triazoles; C508735:isavuconazole; C101425:posaconazole; D015725:Fluconazole; D065819:Voriconazole