Cathepsin B inhibitory activities of three new phthalate derivatives isolated from seahorse, Hippocampus Kuda Bleeler.
Three new phthalate acid derivatives, 2,12-diethyl-11-methylhexadecyl 2-ethyl-11-methylhexadecyl phthalate (1), 2-ethyldecyl 2-ethylundecyl phthalate (2), and bis(2-ethyldodecyl) phthalate (3), were isolated from seahorse, Hippocampus Kuda Bleeler, together with a known natural analog bis(2-ethylheptyl) phthalate (4). The structures of these compounds were elucidated mainly by means of the comprehensive analysis of their NMR spectroscopic data. The four phthalate derivatives showed dose-dependent cathepsin B inhibitions activities with IC(50) values of 0.13 mM (1), 0.21 mM (2), 0.18 mM (3), and 0.29 mM (4), respectively.
Li
Yong
Y
Marine Bioprocess Research Center, Pukyong National University, Busan 608-737, Republic of Korea.
Qian
Zhong-Ji
ZJ
Kim
Se-Kwon
SK
D000818:Animals; D002401:Cathepsin B / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002681:China; D004305:Dose-Response Relationship, Drug; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010795:Phthalic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D023701:Smegmamorpha
D010795:Phthalic Acids; C032279:phthalic acid; D002401:Cathepsin B