Antidiuretic hormone and osmolality in patients with Ménière's disease.
Plasma antidiuretic hormone (p-ADH) and plasma osmolality (p-Osm) levels were studied in patients with Ménière's disease. In 147 cases, the p-ADH levels were measured during remission and in the acute phase of the disease. In 100 of 147 cases, the p-Osm levels were determined both in remission and in the acute phase. In remission, the p-ADH and p-Osm levels were higher than the normal limits. In the acute phase, the p-ADH level was higher than that in remission, consistent with previous reports. Moreover, the p-Osm level was unchanged. Although the p-ADH level is regulated by that of p-Osm, the kidney must show an escape phenomenon from antidiuresis. Besides, other factors must increase the amount of p-ADH. Further study is needed to reveal the cause of the rise in p-ADH and p-Osm levels.
Kakigi
Akinobu
A
Department of Otolaryngology, Kochi Medical School, Nankoku, Kochi, Japan. kakigia@kochi-u.ac.jp
Takeda
Taizo
T
D006309:Hearing; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D008875:Middle Aged; D009994:Osmolar Concentration; D012008:Recurrence; D012720:Severity of Illness Index; D014667:Vasopressins / Q000097:blood; D014717:Vertigo / Q000209:etiology / Q000503:physiopathology
D014667:Vasopressins