title: Clinical evaluation of polypropylene glycol-based caries detecting dyes for primary and permanent carious dentin.
abstract: OBJECTIVE
  The aim of this study was to compare the clinical efficacy of new caries detecting dye Caries Check Blue (CCB) with Caries Check (CC) and Caries Detector (CD) using a laser fluorescence device (DIAGNOdent).
  
  
  METHODS
  Primary and permanent teeth with dentin caries were stained with polypropylene glycol (MW=300) based new caries detecting dyes CCB, CC, or propylene glycol (MW=76) based CD. In the CCB and CC groups, stained dentin was completely removed. In the CD groups, pink-stained dentin was retained according to the manufacturers' instructions. Cavities before and after caries removal were measured with the DIAGNOdent. Data were analyzed using ANOVA and Fisher's PLSD multiple comparison test at alpha=0.05. Regression analyses were performed between DIAGNOdent readings and scores obtained from the clinical parameters.
  
  
  RESULTS
  The DIAGNOdent readings after caries removal were: primary-CCB (13.2+/-10.4), primary-CC (14.3+/-16.7), primary-CD (9.0+/-5.2), permanent-CCB (22.7+/-13.4), permanent-CC (10.6+/-6.8) and permanent-CD (9.7+/-9.0). Significant differences were identified between the permanent-CCB and all other groups. Correlation coefficients between DIAGNOdent readings and clinical parameters were low.
  
  
  CONCLUSIONS
  When dentin stained with Caries Check Blue or Caries Check was completely removed, the DIAGNOdent readings were higher than those recorded when palely-stained pink dentin was retained with the Caries Detector, with significant difference observed for the permanent-CCB group. Caries Check Blue may be used clinically to avoid excessive removal of caries-affected or sound dentin in permanent teeth but not in primary teeth.
authors.affiliation: Nagasaki University Graduate School of Biomedical Sciences, Medical and Dental Sciences, Unit of Translational Medicine, Department of Pediatric Dentistry, 1-7-1, Sakamoto, Nagasaki, 852-8588, Japan. hosoya@nagasaki-u.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Hosoya
authors.forename: T
authors.initials: T
authors.lastname: Taguchi
authors.forename: S
authors.initials: S
authors.lastname: Arita
authors.forename: F R
authors.initials: FR
authors.lastname: Tay
mesh_terms: D001557:Benzenesulfonates; D002648:Child; D002675:Child, Preschool; D003116:Color; D004396:Coloring Agents; D003731:Dental Caries / Q000175:diagnosis* / Q000473:pathology; D003737:Dental Cavity Preparation / Q000379:methods; D003804:Dentin / Q000473:pathology*; D005456:Fluorescent Dyes; D006244:Hardness; D006801:Humans; D007834:Lasers; D008970:Molecular Weight; D014677:Pharmaceutical Vehicles; D023861:Photography, Dental; D011108:Polymers; D011409:Propylene Glycols; D012235:Rhodamines; D014094:Tooth, Deciduous / Q000473:pathology*
chemical_list: D001557:Benzenesulfonates; C089090:Caries Detector; D004396:Coloring Agents; D005456:Fluorescent Dyes; D014677:Pharmaceutical Vehicles; D011108:Polymers; D011409:Propylene Glycols; D012235:Rhodamines; C012504:polypropylene glycol; C022027:lissamine rhodamine B; C006796:brilliant blue