title: Complete genomic sequence of the goat prion protein gene (PRNP).
abstract: Prion protein genetics plays a central role in transmissible spongiform encephalopathies, a disease occurring in human and animals. Here we report a 27-kb genomic sequence containing the goat PRNP gene. It shows, both in structure and content, a remarkable similarity with its sheep ortholog and can serve as a basis for future (comparative) studies with reference to the regulation of PRNP gene expression and the search for genetic tools to prevent/control/eradicate (goat) TSE.
authors.affiliation: Department of Nutrition, Genetics and Ethology, Faculty of Veterinary Medicine, Ghent University, 9820, Merelbeke, Belgium Mario.VanPoucke@UGent.be
authors.forename: Mario
authors.initials: M
authors.lastname: Van Poucke
authors.forename: Nicolas
authors.initials: N
authors.lastname: Willemarck
authors.forename: Karine
authors.initials: K
authors.lastname: Hugot
authors.forename: Alex
authors.initials: A
authors.lastname: Van Zeveren
authors.forename: Luc J
authors.initials: LJ
authors.lastname: Peelman
mesh_terms: D000818:Animals; D001483:Base Sequence; D006041:Goats; D008969:Molecular Sequence Data; D011328:Prions / Q000235:genetics*; D017422:Sequence Analysis, DNA
chemical_list: D011328:Prions