title: Human leukocyte antigen class II association with spontaneous recovery from hepatitis B virus infection in Koreans: analysis at the haplotype level.
abstract: It has been speculated that human leukocyte antigen (HLA) alleles are associated with the outcome of hepatitis B virus (HBV) infection although the data obtained from various populations have shown some inconsistencies. A total of 464 HBVinfected Korean individuals (80 spontaneously recovered [SR] and 384 chronically infected [CI]) were selected to investigate the association of HLA class II alleles with the viral clearance and persistence. Our results showed that: 1) multiple HLA class II alleles and haplotypes were associated with viral clearance (DRB1*1302, DRB1*1502, DQB1*0302, DQB1*0609, and related-haplotypes) and persistence (DRB1*0701, DQB1*0301, and related-haplotypes); 2) DRB1*1302 and DQB1* 0609 were more strongly associated with viral clearance. And the association of DQB1*0609 (pc=0.0084; OR, 7.24) with vial clearance was much stronger than previously recognized, DRB1*1302 (pc=0.0038; OR, 4.34); and 3) linkage to a specific DPB1 allele in a haplotype strengthened the association with viral clearance, although DPB1 itself was not associated with the outcome. These results indicate the existence of multiple factors controlling viral clearance in the HLA class II gene region. Further extended investigation on the genetic factors related to the outcome of HBV infection will provide valuable insights into the understanding of the mechanisms involved.
authors.affiliation: Department of Gastroenterology, Genomic Research Center for Gastroenterology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Sung Won
authors.initials: SW
authors.lastname: Cho
authors.forename: Jae Youn
authors.initials: JY
authors.lastname: Cheong
authors.forename: Young Su
authors.initials: YS
authors.lastname: Ju
authors.forename: Do Hoon
authors.initials: DH
authors.lastname: Oh
authors.forename: Young Ju
authors.initials: YJ
authors.lastname: Suh
authors.forename: Kyung Wha
authors.initials: KW
authors.lastname: Lee
mesh_terms: D000483:Alleles; D005802:Genes, MHC Class II; D006680:HLA Antigens / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D006239:Haplotypes; D006509:Hepatitis B / Q000276:immunology* / Q000821:virology*; D006515:Hepatitis B virus / Q000235:genetics; D006801:Humans; D016130:Immunophenotyping; D007723:Korea; D008957:Models, Genetic; D012074:Remission Induction; D016896:Treatment Outcome
chemical_list: D006680:HLA Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens