[Neuromeningeal cryptococcosis in patients apparently non-immunodeficient: report of 3 cases in Dakar, Senegal].
Cryptococcal infection is common in immunocompromised patients. Its occurrence in immuno-competent patients is rare. We report here 3 cases of neuromeningeal cryptococcosis in patients without any immunosuppressive documented factors. They were respectively 25, 36 and 50 years old presenting clinical signs of chronic meningo-encephalitis. The HIV test was negative for all of them and the CD4 counts were normal. One patient died on the seventh day of the treatment with amphotericin B; the second was discharged on parents' request, while the third patient improved with intravenous fluconazole. This study suggests that when facing a sub-acute or chronic meningitis, an investigation for cryptococcal infection is recommended as before AIDS epidemic.
Ndiaye
M
M
Service de neurologie, CHU de Fann, BP 5035 Dakar, Sénégal. ngouille@hotmail.com
Soumaré
M
M
Mapoure
Y N
YN
Seydi
M
M
Sène-Diouf
F
F
Ngom
N F
NF
Sène
M S
MS
Sow
A D
AD
Diop
A G
AG
Sow
P S
PS
Ndiaye
M M
MM
Ndiaye
I P
IP
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D017809:Fatal Outcome; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D018023:HIV Seronegativity; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D016919:Meningitis, Cryptococcal / Q000175:diagnosis* / Q000276:immunology; D008875:Middle Aged; D012675:Senegal; D016896:Treatment Outcome
D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole