Altered sleep brain functional connectivity in acutely depressed patients.
Recent evidence suggests that problems in information processing within neural networks may underlie depressive disease. In this study, we investigated whether sleep functional brain networks are abnormally organized during a major depressive episode (MDE). We characterized spatial patterns of functional connectivity by computing the "synchronization likelihood" (SL) of 19 sleep EEG channels in 11 acutely depressed patients [42 (20-51) years] and 14 healthy controls [32.9 (27-42) years]. To test whether disrupting an optimal pattern ["small-world network" (SWN)] of functional brain connectivity underlies MDE, graph theoretical measures were then applied to the resulting synchronization matrices, and a clustering coefficient (C, measure of local connectedness) and a shortest path length (L, measure of overall network integration) were determined. In the depressed group, the mean SL was lower in the delta, theta and sigma frequency bands. Acutely depressed patients showed a significantly lower path length in the theta and delta frequency bands, whereas the cluster coefficient showed no significant changes. The present study provides further support that sleep functional brain networks exhibit "small-world" properties. Sleep neuronal functional networks in depressed patients are characterized by a functional reorganization with a lower mean level of global synchronization and loss of SWN characteristics. These results argue for considering an MDE as a problem of neuronal network organization and a problem of information processing.
Leistedt
Samuël J J
SJ
Sleep Unit and Laboratory of Psychiatric Research, Department of Psychiatry, Erasme Academic Hospital, Université Libre de Bruxelles, Brussels, Belgium. samuel.leistedt@ulb.ac.be
Coumans
Nathalie
N
Dumont
Martine
M
Lanquart
Jean-Pol
JP
Stam
Cornelis J
CJ
Linkowski
Paul
P
D000328:Adult; D001921:Brain / Q000503:physiopathology*; D016000:Cluster Analysis; D003344:Cortical Synchronization; D003700:Delta Rhythm; D003865:Major Depressive Disorder / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000503:physiopathology; D012815:Signal Processing, Computer-Assisted; D012890:Sleep / Q000502:physiology*; D013826:Theta Rhythm; D055815:Young Adult