[Prognostic factors of colorectal carcinoma in the elderly after radical surgery].
OBJECTIVE
To evaluate the prognostic factors of colorectal carcinoma in the elderly aged over 70 after radical surgery.


METHODS
263 colorectal carcinoma patients aged 74.9, 147 males and 115 females, underwent radical surgery, including right hemicolectomy (n=48), left hemicolectomy (n=11), transverse colectomy (n=8), sigmoid resection (n=27), low anterior resection (n=103), abdominoperineal resection (n=58), and Hartmann's operation (n=7). Survival analysis was conducted using Kaplan-Meier method, and multivariate analysis was conducted with Cox regression to analyze the prognostic factors.


RESULTS
The post-operative complication rate was 14. 4%. The 30-day mortality was 1.1%. The overall 5-year survival rate was 70.5%, and the 5-year survival rates of the patients with ASA grades I, II, and III were 84.8%, 71.8%, and 61.9% respectively. Univariate analysis showed that the predictors of survival were age, co-morbidity, ASA score, postoperative complication, preoperative serum albumin concentration, preoperative hemoglobin level, gross tumor configuration, tumor stage, neoplastic intestinal obstruction, and lymph node metastasis. Multivariate analysis showed that patient sex, complication, operative complication, gross tumor configuration, depth of infiltration, lymph node metastasis, and tumor staging were independent influencing factors od prognosis.


CONCLUSIONS
The prognosis of colorectal carcinoma in the elderly after radical surgery is good. The prognostic factors include age, postoperative complication, and pre-operative serum albumin concentration, and gross tumor configuration, depth of tumor invasion, lymph node metastasis, and tumor stage.
Liang
Jian-wei
JW
Department of Abdominal Surgery, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Bai
Xiao-feng
XF
Zhou
Zhi-xiang
ZX
Zhao
Dong-bing
DB
Wang
Cheng-feng
CF
Zhao
Ping
P
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003082:Colectomy / Q000379:methods; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D015996:Survival Rate