title: Leptin gene, leptin gene receptor polymorphisms and body weight in pregnant women with type 1 diabetes mellitus.
abstract: Leptin, as well as many other hormones, may play an important role in the pathogenesis of obesity. Several genetic variants of both leptin and its receptor genes may influence human body weight
  
  
  OBJECTIVE
  To investigate the role of leptin gene polymorphism promotion region (-2548G/A) and leptin gene receptor polymorphism (668 A/G) in regulation of body weight in the group of women with type 1 diabetes (PGDM-1).
  
  
  METHODS
  78 PGDM-1 first trimester pregnant women were qualified for the study group (SG). They were divided into normal and overweight subgroups, based on pre-pregnancy BMI. Control group (CG) consisted of first trimester healthy pregnant women with normal pre-pregnancy body weight Genetic variants of leptin gene and its receptor were analyzed with the help of PCR-RFLP assays. In the SG, the following metabolic parameters were estimated: MBG, HbA1c, insulin dose, LDL, HDL, T-CHOL, triglycerids, creatinine, creatinine clearance and blood pressure.
  
  
  RESULTS
  A tendency for the majority of homozygous A and G variants in LEP -2548 G/A and LEPR 668 A/G was found in overweight and obese patients, in comparison to normal-weight subjects. No specific differences in selected first trimester metabolic parameters were found in relation to patients' genotypes in the diabetic group.
authors.affiliation: Department of Obsterics and Women Diseases, Poznań University of Medical Sciences, Poland. ralfiho@02.pl
authors.forename: Rafał
authors.initials: R
authors.lastname: Iciek
authors.forename: Ewa
authors.initials: E
authors.lastname: Wender-Ozegowska
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Seremak-Mrozikiewicz
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Drews
authors.forename: Jacek
authors.initials: J
authors.lastname: Brazert
authors.forename: Marek
authors.initials: M
authors.lastname: Pietryga
mesh_terms: D000328:Adult; D015992:Body Mass Index; D001835:Body Weight / Q000235:genetics*; D016022:Case-Control Studies; D004252:DNA Mutational Analysis / Q000379:methods; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005260:Female; D006801:Humans; D020738:Leptin / Q000235:genetics*; D009765:Obesity / Q000235:genetics; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000235:genetics*; D054411:Receptors, Leptin / Q000235:genetics*
chemical_list: C515448:LEPR protein, human; D020738:Leptin; D054411:Receptors, Leptin