Pyrrospirones A and B, apoptosis inducers in HL-60 cells, from an endophytic fungus, Neonectria ramulariae Wollenw KS-246.
Pyrrospirones A and B have been isolated from unpolished rice cultures of the endophytic fungus Neonectria ramulariae Wollenw KS-246. Their absolute stereostructures (1 and 2) were elucidated through spectroscopic methods using 1D and 2D NMR techniques and chemical transformations, including the modified Mosher's method. The compounds exhibited cytotoxicity and induced apoptosis in human promyelocytic leukemia HL-60 cells.
Shiono
Yoshihito
Y
Department of Bioresource Engineering, Faculty of Agriculture, Yamagata University, Wakabamachi 1-23, Tsuruoka, Yamagata 997-8555, Japan. yshiono@tds1.tr.yamagata-u.ac.jp
Shimanuki
Keiko
K
Hiramatsu
Fuminori
F
Koseki
Takuya
T
Tetsuya
Murayama
M
Fujisawa
Nozomi
N
Kimura
Ken-ichi
K
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D006999:Hypocreales / Q000737:chemistry*; D007564:Japan; D015394:Molecular Structure; D012275:Oryza / Q000382:microbiology; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D000470:Alkaloids; D000970:Antineoplastic Agents; D013141:Spiro Compounds; C534099:pyrrospirone A; C534100:pyrrospirone B