title: Trends in nasopharyngeal carriage of Streptococcus pneumoniae among children attending daycare centers in southeastern France from 1999 to 2006.
abstract: Pneumococcal nasopharyngeal carriage, serotype distribution, and penicillin-susceptibility were monitored among children attending daycare centers in France from 1999 to 2006 to assess the impact of pneumococcal conjugate vaccine and antibiotic-reducing policies. Pneumococcal carriage remained stable. Immunization rates reached 68% in 2006. Serotype distribution shifted significantly from vaccine serotypes to vaccine-related and nonvaccine serotypes. Antibiotic treatments fell by 50%.
authors.affiliation: Service d'Infectiologie and daggerDépartement de Santé Publique, CHU de Nice, France. dunais.b@chu-nice.fr
authors.forename: Brigitte
authors.initials: B
authors.lastname: Dunais
authors.forename: Pascale
authors.initials: P
authors.lastname: Bruno
authors.forename: Hélène
authors.initials: H
authors.lastname: Carsenti-Dellamonica
authors.forename: Pia
authors.initials: P
authors.lastname: Touboul
authors.forename: Pierre
authors.initials: P
authors.lastname: Dellamonica
authors.forename: Christian
authors.initials: C
authors.lastname: Pradier
mesh_terms: D002353:Carrier State / Q000453:epidemiology*; D002656:Child Day Care Centers; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D005602:France / Q000453:epidemiology; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D007223:Infant; D008297:Male; D022401:Meningococcal Vaccines; D008826:Microbial Sensitivity Tests; D009305:Nasopharynx / Q000382:microbiology*; D010403:Penicillin Resistance; D011008:Pneumococcal Infections / Q000453:epidemiology*; D022242:Pneumococcal Vaccines; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification / Q000302:isolation & purification*
chemical_list: D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022401:Meningococcal Vaccines; D022242:Pneumococcal Vaccines