Atrophy and decreased activation of fronto-parietal attention areas contribute to higher visual dysfunction in posterior cortical atrophy.
Voxel-based morphometry and functional magnetic resonance imaging demonstrated severe atrophy and decreased activation of visual attention areas and occipital lobes in a patient with early posterior cortical atrophy compared with healthy controls and patients with early Alzheimer's disease. Our complex approach indicates that structures responsible for attention can be damaged early in posterior cortical atrophy and may contribute to the characteristic decline in higher visual functions.
Feldmann
Adam
A
Department of Neurology, University of Pecs, 2 Ret St, Pecs, 7623 Hungary.
Trauninger
Anita
A
Toth
Lilla
L
Kotek
Gyula
G
Kosztolanyi
Peter
P
Illes
Eniko
E
Pfund
Zoltan
Z
Komoly
Samuel
S
Nagy
Ferenc
F
Illes
Zsolt
Z
D001284:Atrophy / Q000150:complications* / Q000473:pathology*; D001288:Attention / Q000502:physiology*; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010296:Parietal Lobe / Q000473:pathology*; D010468:Perceptual Disorders / Q000175:diagnosis / Q000209:etiology*; D014796:Visual Perception / Q000502:physiology*