Metabolic syndrome in carbon disulfide-poisoned subjects in Korea: does chemical poisoning induce metabolic syndrome?
OBJECTIVE
Mass carbon disulfide (CS(2)) poisoning was reported at a viscose rayon factory in Korea. We evaluated the association between CS(2) poisoning and the prevalence of metabolic syndrome.


METHODS
The cases (n = 170) involved CS(2)-poisoned subjects, who participated in a health examination conducted at a hospital in Korea in 2005. The controls (n = 170) were selected randomly from the participants in the third Korean National Health and Nutrition Examination Survey. Metabolic syndrome was defined as having at least three of following metabolic abnormalities: abdominal obesity, elevated triglyceride, reduced high-density lipoprotein cholesterol, elevated blood pressure, and elevated fasting glucose levels.


RESULTS
After adjusting for covariates (age, gender, education, marital status, alcohol consumption, and smoking), CS(2)-poisoned subjects had an increased risk of metabolic syndrome (prevalence ratio 1.57, 95% CI 1.25-1.98).


CONCLUSIONS
The findings suggest that CS(2) poisoning may increase the risk of metabolic syndrome.
Jhun
Hyung-Joon
HJ
Department of Occupational and Environmental Medicine, College of Medicine, Korea University, Ansan, Republic of Korea.
Lee
Sang-Yoon
SY
Yim
Sang-Hyuk
SH
Kim
Mi-Jung
MJ
Park
Kyung-Keun
KK
Cho
Sung-Il
SI
D000395:Air Pollutants, Occupational / Q000506:poisoning*; D002246:Carbon Disulfide / Q000506:poisoning*; D005260:Female; D006801:Humans; D019570:Inhalation Exposure; D007723:Korea / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D008875:Middle Aged; D009784:Occupational Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D016273:Occupational Exposure / Q000009:adverse effects* / Q000706:statistics & numerical data; D016272:Occupational Health; D055105:Waist Circumference; D017132:Workplace
D000395:Air Pollutants, Occupational; D002246:Carbon Disulfide