Expandable endodermal progenitors: new tools to explore endoderm and its derivatives.
In the two recent issues of Cell Stem Cell, Rossant and colleagues (Seguin et al., 2008) produced expandable endoderm from hESCs by constitutive expression of Sox transcription factors, while Brickman and associates (Morrison et al., 2008) used a reporter gene strategy to isolate replicating anterior definitive endoderm from mESCs.
Semb
Henrik
H
Stem Cell Center, Lund University, BMC B10, S-221 84 Lund, Sweden. henrik.semb@med.lu.se
D000818:Animals; D000943:Antigens, Differentiation / Q000378:metabolism; D002454:Cell Differentiation; D019070:Cell Lineage; D053595:Embryonic Stem Cells / Q000166:cytology* / Q000378:metabolism; D004707:Endoderm / Q000166:cytology* / Q000378:metabolism; D051519:Fibroblast Growth Factor 4 / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000502:physiology; D008648:Mesoderm / Q000166:cytology / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D009928:Organ Specificity; D010179:Pancreas / Q000502:physiology; D055760:SOXF Transcription Factors / Q000235:genetics / Q000378:metabolism; D015533:Transcriptional Activation
D000943:Antigens, Differentiation; C496446:Fgf4 protein, mouse; D051519:Fibroblast Growth Factor 4; C109188:SOX17 protein, human; C484456:SOX7 protein, human; D055760:SOXF Transcription Factors