Comparing drug effectiveness at health plans: the ethics of cluster randomized trials.
"Cluster randomized trials," in which groups of patients are randomly assigned to different therapeutic interventions, provide a powerful way of evaluating drugs. CRTs have not been widely used, in good part because of concerns about whether patients must give informed consent to participate in them. A better understanding of how CRTs fit into clinical practice resolves the concerns.
Sabin
James E
JE
Harvard Medical School, USA.
Mazor
Kathleen
K
Meterko
Vanessa
V
Goff
Sarah L
SL
Platt
Richard
R
D016000:Cluster Analysis; D003625:Data Collection; D006270:Health Facility Administrators; D006801:Humans; D007258:Informed Consent / Q000941:ethics*; D017060:Patient Satisfaction; D016032:Randomized Controlled Trials as Topic / Q000941:ethics*