[Expression and clinical significance of cyclin H and CDK7 in human hemangiomas].
OBJECTIVE
To investigate the expression and clinical significance of cyclin H and cyclin-dependent kinase 7 (CDK7) in human hemangiomas.


METHODS
Immunohistochemistry technique was used to measure the expression of cyclin H and CDK7 proteins in proliferative, involuting hemangiomas and normal skin tissues. Immunohistochemical technique for factor VIII-related antigen was used to prove that the cells which expressed cyclin H and CDK7 were endothelial cells. Average optical density and positive area of the expression of cyclin H and CDK7 proteins in proliferative, involuting hemangiomas and normal skin tissues were measured by image analysis (HPIAS-1000).


RESULTS
The expression of cyclin H and CDK7 protein in proliferating hemangiomas was significantly higher than that in involuting hemangiomas and normal skin tissues (P < 0.01). But no significant difference was found in the expression of cyclin H and CDK7 protein between involuting hemangiomas and normal skin tissues (P > 0.05).


CONCLUSIONS
cyclin H and CDK7 may play an important role in the generation and development of human hemangiomas.
Liu
Juan
J
Department of Geriatrics, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Zhang
Duan-Lian
DL
Shan
Sheng-Guo
SG
D056748:Cyclin H / Q000378:metabolism*; D018844:Cyclin-Dependent Kinases / Q000378:metabolism*; D006391:Hemangioma / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D012878:Skin Neoplasms / Q000378:metabolism*; D000095043:Cyclin-Dependent Kinase-Activating Kinase
D056748:Cyclin H; D018844:Cyclin-Dependent Kinases; D000095043:Cyclin-Dependent Kinase-Activating Kinase; C000722416:CDK7 protein, human