title: Intravenous immunoglobulin therapy for severe arthritis associated with human parvovirus B19 infection.
abstract: Symptoms caused by acute human parvovirus B19 (HPV-B19) infection can vary considerably, from asymptomatic to severely symptomatic. A 39-year-old Japanese woman complained of sudden, severe arthralgia with edematous limbs coincident with an outbreak of HPV-B19 infection at the elementary school attended by her daughter. A diagnosis of acute HPV-B19 infection was made by the detection of serum antibody to HPV-B19 IgM and HPV-B19 DNA. Magnetic resonance imaging revealed bilateral synovitis of the cubital joints. The patient was immunocompetent and suffered from severe arthralgia associated with persistent HPV-B19 viremia for more than 4 months after the diagnosis of acute HPV-B19 infection. The administration of high-dose intravenous immunoglobulin resulted in remission, with little change in the serum HPV-B19 DNA level. Even in our immunocompetent patient, severe and prolonged arthritis was found to be associated with persistent viremia.
authors.affiliation: Department of General Medicine, Kyushu University Hospital, 3-1-1 Maidashi, Fukuoka, 812-8582, Japan.
authors.forename: Eiichi
authors.initials: E
authors.lastname: Ogawa
authors.forename: Shigeru
authors.initials: S
authors.lastname: Otaguro
authors.forename: Masayuki
authors.initials: M
authors.lastname: Murata
authors.forename: Mosaburo
authors.initials: M
authors.lastname: Kainuma
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Sawayama
authors.forename: Norihiro
authors.initials: N
authors.lastname: Furusyo
authors.forename: Jun
authors.initials: J
authors.lastname: Hayashi
mesh_terms: D000328:Adult; D001170:Arthritis, Infectious / Q000628:therapy* / Q000821:virology; D001842:Bone and Bones / Q000000981:diagnostic imaging; D004550:Elbow; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D010322:Parvoviridae Infections / Q000175:diagnosis / Q000628:therapy* / Q000821:virology; D016732:Parvovirus B19, Human / Q000235:genetics / Q000302:isolation & purification*; D011877:Radionuclide Imaging
chemical_list: D016756:Immunoglobulins, Intravenous