title: Clinical characteristics of nosocomial rotavirus infection in children in Taiwan.
abstract: OBJECTIVE
  The aim of this study was to determine the incidence and clinical characteristics of nosocomial rotavirus infection (NRI) among hospitalized children.
  
  
  METHODS
  We collected data of children in the Department of Pediatrics with positive stool rotavirus antigen tests. Cases of an admission diagnosis of acute gastroenteritis or a positive stool rotavirus antigen test within 3 days of admission, representing community-acquired infections, were excluded. Both VP4 and VP7 genotyping of the rotaviruses was done.
  
  
  RESULTS
  There were 98 patients who met the inclusion criteria during the 3-year period. The incidence density was 0.58 per 1000 patient-days in our series. Among these patients, 59 (60%) had underlying diseases. The intermediate intensive care unit had the highest incidence density (2.8 per 1000 patient-days). Overcrowding of the care unit, inappropriate hand hygiene, and inadequate isolation and cohorting predisposed to the high rate. Genotypes among 79 (80%) rotaviruses tested showed that 42% belonged to the novel genotype, G9P[8].
  
  
  CONCLUSIONS
  NRI may cause significant morbidity in hospitalized children, especially young infants and those with underlying diseases. Infection control with hospital surveillance, strict isolation and cohort care should be adopted to prevent the spread of rotavirus among special care units.
authors.affiliation: Department of Pediatrics, Yunlin Branch, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.
authors.forename: Jian-Te
authors.initials: JT
authors.lastname: Lee
authors.forename: Chun-Nan
authors.initials: CN
authors.lastname: Lee
authors.forename: Pei-Lan
authors.initials: PL
authors.lastname: Shao
authors.forename: Luan-Yin
authors.initials: LY
authors.lastname: Chang
authors.forename: Chun-Yi
authors.initials: CY
authors.lastname: Lu
authors.forename: Ping-Ing
authors.initials: PI
authors.lastname: Lee
authors.forename: Chun-Min
authors.initials: CM
authors.lastname: Chen
authors.forename: Chin-Yun
authors.initials: CY
authors.lastname: Lee
authors.forename: Li-Min
authors.initials: LM
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003428:Cross Infection / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D012400:Rotavirus Infections / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D013624:Taiwan