title: Role of protease activated receptor-2 in lymph node metastasis of uterine cervical cancers.
abstract: BACKGROUND
  Protease activated receptor-2 (PAR-2) has been implicated in cellular proliferation, invasion and metastasis in various tumors. Lymph node metastasis is an important patient prognostic factor for uterine cervical cancers. This prompted us to study the role of PAR-2 in lymph node metastasis of uterine cervical cancers.
  
  
  METHODS
  Thirty patients underwent surgery for uterine cervical cancers. PAR-2 histoscores and mRNA levels were determined by immunohistochemistry and real-time reverse transcription-polymerase chain reaction, respectively. Patient prognosis was analyzed with a 48-month survival rate.
  
  
  RESULTS
  PAR-2 histoscores and mRNA levels significantly (P < 0.05) increased in 12 of 30 metastatic lymph node lesions from the corresponding primary tumor. The 48-month survival rate of the 12 patients with increased PAR-2 levels in metastatic lymph nodes was 42%, while the rate of the other 18 patients with no change in PAR-2 levels was 82%, regardless of histopathological type.
  
  
  CONCLUSIONS
  PAR-2 might work on lymph node metastasis of uterine cervical cancers, and is considered to be a novel prognostic indicator for uterine cervical cancers.
authors.affiliation: Department of Obstetrics and Gynecology, Gifu University School of Medicine, 1-1 Yanagido, Gifu City 501-1194, Japan. israt1317@yahoo.com
authors.forename: Israt
authors.initials: I
authors.lastname: Jahan
authors.forename: Jiro
authors.initials: J
authors.lastname: Fujimoto
authors.forename: Syed Mahfuzul
authors.initials: SM
authors.lastname: Alam
authors.forename: Eriko
authors.initials: E
authors.lastname: Sato
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Tamaya
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012333:RNA, Messenger / Q000032:analysis; D044464:Receptor, PAR-2 / Q000235:genetics / Q000378:metabolism*; D016019:Survival Analysis; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology*
chemical_list: D012333:RNA, Messenger; D044464:Receptor, PAR-2