Steroids linked with amide bond-extended cholesterol.
New type of linear cholesterol-like molecules based on cholesterol extended by attachment of etienic acid derivatives was designed and oligosteroids with two to four units were synthesized. Amide bond was used for inter steroid connections and 1-hydroxybenzotriazole active ester method was adapted for their formations. Use of disteroids as larger building blocks was applied.
Cerný
Ivan
I
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., 166 10 Prague 6, Czech Republic. cerny@ouchb.cas.cz
Budesínský
Milos
M
Pouzar
Vladimír
V
Drasar
Pavel
P
D000577:Amides / Q000737:chemistry*; D000736:Androstenes / Q000737:chemistry*; D002784:Cholesterol / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure
D000577:Amides; D000736:Androstenes; C004251:etienic acid; D002784:Cholesterol