title: Anesthesia for free vascularized tissue transfer.
abstract: Anesthesia may be an important factor in maximizing the success of microsurgery by controlling the hemodynamics and the regional blood flow. The intraanesthetic basic goal is to maintain an optimal blood flow for the vascularized free flap by: increasing the circulatory blood flow, maintaining a normal body temperature to avoid peripheral vasoconstriction, reducing vasoconstriction resulted from pain, anxiety, hyperventilation, or some drugs, treating hypotension caused by extensive sympathetic block and low cardiac output. A hyperdynamic circulation can be obtained by hypervolemic or normovolemic hemodilution and by decrease of systemic vascular resistance. The importance of proper volume replacement has been widely accepted, but the optimal strategy is still open to debate. General anesthesia combined with various types of regional anesthesia is largely preferred for microvascular surgery. Maintenance of homeostasis through avoidance of hyperoxia, hypocapnia, and hypovolemia (all factors that can decrease cardiac output and induce local vasoconstriction) is a well-established perioperative goal. As the ischemia-reperfusion injury could occur, inhalatory anesthetics as sevoflurane (that attenuate the consequences of this process) seem to be the anesthetics of choice.
authors.affiliation: Department of Anesthesia and Intensive Care, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca, Romania. hagaunatalia@gmail.com
authors.forename: Natalia
authors.initials: N
authors.lastname: Hagau
authors.forename: Dan
authors.initials: D
authors.lastname: Longrois
mesh_terms: D000758:Anesthesia; D000765:Anesthesia, Conduction; D018685:Anesthetics, Inhalation; D006400:Hematocrit; D006438:Hemodilution; D006439:Hemodynamics; D006706:Homeostasis; D006801:Humans; D008738:Methyl Ethers; D012039:Regional Blood Flow; D015427:Reperfusion Injury / Q000517:prevention & control; D000077149:Sevoflurane; D013524:Surgical Flaps / Q000098:blood supply; D014655:Vascular Resistance
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane