title: MUC1 expression in canine malignant mammary tumours and relationship to clinicopathological features.
abstract: Mucin-1 (MUC1) is over-expressed in human breast carcinomas and is linked to a poorer prognosis. In this study, MUC1 expression in 32 spontaneous canine malignant mammary tumours was characterised in relation to histological type, mode of growth, grade, lymph node metastases and distant metastases. All tumours exhibited immunostaining for MUC1. In the normal canine mammary gland, MUC1 was expressed mainly in the apical cellular membrane, while in carcinomas MUC1 was detected in the cytoplasm only (56.3%) or in the cytoplasm with membrane accentuation (43.7%). There was a significant association between development of distant metastases and MUC1 over-expression (P=0.03), but no association with histological type, histological grade, mode of growth or lymph node metastasis.
authors.affiliation: Institute of Molecular Pathology and Immunology, Rua Dr. Roberto Frias, s/n, University of Porto, 4200-456 Porto, Portugal.
authors.forename: Joana T
authors.initials: JT
authors.lastname: de Oliveira
authors.forename: Salomé S
authors.initials: SS
authors.lastname: Pinho
authors.forename: Augusto J
authors.initials: AJ
authors.lastname: de Matos
authors.forename: Venceslau
authors.initials: V
authors.lastname: Hespanhol
authors.forename: Celso A
authors.initials: CA
authors.lastname: Reis
authors.forename: Fátima
authors.initials: F
authors.lastname: Gärtner
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000378:metabolism* / Q000473:pathology; D004285:Dogs; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D008207:Lymphatic Metastasis; D015674:Mammary Neoplasms, Animal / Q000378:metabolism* / Q000473:pathology; D018396:Mucin-1 / Q000235:genetics / Q000378:metabolism*; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging / Q000662:veterinary
chemical_list: D018396:Mucin-1