title: Emerging functional roles of cathepsin E.
abstract: Cathepsin E is an intracellular aspartic protease of the endolysosomal pathway. It has been implicated in several physiological and pathological processes however, its exact functional role is yet to be elucidated. The present review gives an account of the major physiological functions that are associated to cathepsin E by various research groups and highlights the conditions developed in cathepsin E deficiency or the conditions where overexpression of cathepsin E is observed.
authors.affiliation: Medical and Natural Sciences Research Centre, University of Tubingen, Ob dem Himmelreich 7, 72074 Tubingen, Germany; Interfacultary Institute of Biochemistry, University of Tubingen, Germany. Electronic address: nousheen.zaidi@gmail.com.
authors.forename: Nousheen
authors.initials: N
authors.lastname: Zaidi
authors.affiliation: Medical and Natural Sciences Research Centre, University of Tubingen, Ob dem Himmelreich 7, 72074 Tubingen, Germany; Interfacultary Institute of Biochemistry, University of Tubingen, Germany.
authors.forename: Clemens
authors.initials: C
authors.lastname: Hermann
authors.affiliation: Medical and Natural Sciences Research Centre, University of Tubingen, Ob dem Himmelreich 7, 72074 Tubingen, Germany; Interfacultary Institute of Biochemistry, University of Tubingen, Germany.
authors.forename: Timo
authors.initials: T
authors.lastname: Herrmann
authors.affiliation: Medical and Natural Sciences Research Centre, University of Tubingen, Ob dem Himmelreich 7, 72074 Tubingen, Germany; Interfacultary Institute of Biochemistry, University of Tubingen, Germany.
authors.forename: Hubert
authors.initials: H
authors.lastname: Kalbacher
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D020059:Cathepsin E / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D000949:Histocompatibility Antigens Class II / Q000378:metabolism*; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D009369:Neoplasms / Q000201:enzymology*
chemical_list: D000949:Histocompatibility Antigens Class II; D020059:Cathepsin E