Matriderm versus Integra: a comparative experimental study.
OBJECTIVE
To compare engraftment rates and vascularisation in a rat model using either Integra Artificial Skin or Matriderm.


METHODS
Matriderm and the dermal part of Integra were compared in a two-step procedure including matrix implantation and subsequent epidermal grafting. Neonatal rat epidermis was used as coverage to test for rapid and complete take.


RESULTS
Efficiency and quality of vascularisation expressed by take rate of epidermis, and thickness of resulting neodermis, were identical for both matrices.


CONCLUSIONS
This first comparison of Matriderm with Integra in a rat model revealed no major differences in engraftment rates or vascularisation.
Schneider
Joerg
J
Paediatric Burn Centre, Plastic and Reconstructive Surgery, Department of Surgery, University Children's Hospital, Steinwiesstrasse 75, Zürich, Switzerland.
Biedermann
Thomas
T
Widmer
Daniel
D
Montano
Irene
I
Meuli
Martin
M
Reichmann
Ernst
E
Schiestl
Clemens
C
D000818:Animals; D000831:Animals, Newborn; D002809:Chondroitin Sulfates / Q000502:physiology*; D003094:Collagen / Q000502:physiology*; D004549:Elastin / Q000502:physiology*; D006085:Graft Survival / Q000502:physiology; D051381:Rats; D012867:Skin / Q000098:blood supply* / Q000473:pathology; D016038:Skin Transplantation / Q000379:methods
C114835:integra artificial skin; C532298:matriderm; D002809:Chondroitin Sulfates; D003094:Collagen; D004549:Elastin