title: Efficient synthesis and biological evaluation of two modafinil analogues.
abstract: Non classical bioisosters of modafinil featuring interesting biological profile have been easily produced through replacement of the sulfoxide function with a carbonyl group and modification of the carboxylic acid amide functionality.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Via Fossato di Mortara 19, 44100 Ferrara, Italy. drc@unife.it
authors.forename: Carmela
authors.initials: C
authors.lastname: De Risi
authors.forename: Luca
authors.initials: L
authors.lastname: Ferraro
authors.forename: Gian P
authors.initials: GP
authors.lastname: Pollini
authors.forename: Sergio
authors.initials: S
authors.lastname: Tanganelli
authors.forename: Filippo
authors.initials: F
authors.lastname: Valente
authors.forename: Augusto C
authors.initials: AC
authors.lastname: Veronese
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds / Q000737:chemistry* / Q000378:metabolism; D000697:Central Nervous System Stimulants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D003627:Data Interpretation, Statistical; D008297:Male; D000077408:Modafinil; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000737:chemistry / Q000378:metabolism; D013237:Stereoisomerism
chemical_list: D001559:Benzhydryl Compounds; D000697:Central Nervous System Stimulants; D012701:Serotonin; D000077408:Modafinil