Insight into the role of HOG pathway components Ssk2p, Pbs2p, and Hog1p in the opportunistic yeast Candida lusitaniae.
In the present study, we have investigated the role of SSK2, PBS2, and HOG1, encoding modules of the high-osmolarity-glycerol mitogen-activated protein kinase pathway in Candida lusitaniae. Functional analysis of mutants indicated that Ssk2p, Pbs2p, and Hog1p are involved in osmotolerance, drug sensitivity, and heavy metal tolerance but not in oxidant stress adaptation.
Boisnard
Stéphanie
S
Programme Chimiorésistance des Levures Pathogènes, EA209 Eucaryotes Pathogènes: Transports Membranaires et Chimiorésistance, UFR des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, 75006 Paris, France.
Ruprich-Robert
Gwenaël
G
Florent
Martine
M
Da Silva
Bruno
B
Chapeland-Leclerc
Florence
F
Papon
Nicolas
N
D002175:Candida / Q000201:enzymology* / Q000235:genetics / Q000502:physiology; D002177:Candidiasis / Q000382:microbiology*; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism*; D005990:Glycerol / Q000378:metabolism*; D006801:Humans; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism*; D009994:Osmolar Concentration; D015398:Signal Transduction
D005656:Fungal Proteins; D020928:Mitogen-Activated Protein Kinases; D005990:Glycerol