title: Depression after first-ever ischemic stroke: the prognostic role of neuroanatomic subtypes in clinical practice.
abstract: BACKGROUND
  The relationship between poststroke depression (PSD) and Oxford Community Stroke Project (OCSP) subtypes is uncertain.
  
  
  METHODS
  713 first-ever ischemic stroke patients recruited in a multicenter investigation to evaluate prevalence, onset time and severity of PSD. Stroke subtypes were considered as independent predictors of PSD occurrence by logistic regression.
  
  
  RESULTS
  Results showed similar prevalence of PSD in stroke subtypes with the exception of TACI. Only patients with total anterior cerebral ischemia (TACI) showed a higher PSD occurrence (OR: 1.76, CI: 1.14-2.71). Multivariate analysis underlined the role of severe functional impairment, previous depressive disorders and female sex. Neither the OCSP subgroups, nor left and right involvement were predictive of PSD. TACI and left-sided strokes were related to higher depression severity scores.
  
  
  CONCLUSIONS
  In clinical practice, the definition of neuroanatomic subtypes provides little contribution specifically to PSD prediction after a first-ever ischemic stroke.
authors.affiliation: Neurological Clinic, Azienda Ospedali Riuniti, Ancona, Italy.
authors.forename: Leandro
authors.initials: L
authors.lastname: Provinciali
authors.forename: Stefano
authors.initials: S
authors.lastname: Paolucci
authors.forename: Riccardo
authors.initials: R
authors.lastname: Torta
authors.forename: Vito
authors.initials: V
authors.lastname: Toso
authors.forename: Beatrice
authors.initials: B
authors.lastname: Gobbi
authors.forename: Carlo
authors.initials: C
authors.lastname: Gandolfo
mesh_terms: D000368:Aged; D001037:Aphasia / Q000209:etiology / Q000523:psychology; D002545:Brain Ischemia / Q000145:classification / Q000000981:diagnostic imaging / Q000473:pathology / Q000523:psychology*; D002544:Cerebral Infarction / Q000000981:diagnostic imaging / Q000473:pathology / Q000523:psychology; D003863:Depression / Q000453:epidemiology / Q000209:etiology*; D003866:Depressive Disorder / Q000453:epidemiology / Q000209:etiology*; D004292:Dominance, Cerebral; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed