Transforming growth factor-alpha and nonsyndromic cleft lip with or without palate or cleft palate only in Kelantan, Malaysia.
OBJECTIVE
To determine the frequency of the transforming growth factor-alpha (TGFalpha) Taq1 polymorphism in nonsyndromic cleft lip with or without cleft palate (CL+/-P) and cleft palate only (CP) in Kelantan, Malaysia.


METHODS
The study was conducted at the Combined Cleft Clinic and at the Human Genome Centre in Hospital Universiti Sains Malaysia in Kelantan, Malaysia.


METHODS
We examined the C2/Taq1 variant of the TGFalpha gene in 46 patients with nonsyndromic CL+/-P or CP only and in 33 controls. The TGFalpha genotype frequencies in patients were compared with those in controls using the chi-square or Fisher exact test. DNA samples were obtained from peripheral blood.


RESULTS
No association was found between TGFalphaTaq1 polymorphism and CL+/-P or CP in this case-control study. In addition, no homozygosity for the rare allele C2 was noted in CL+/-P, CP, or the controls.


CONCLUSIONS
No evidence of TGFalphaTaq1 polymorphism was observed in association with CL+/-P and CP in this study.
Rahman
Roselinda Abdul
RA
School of Dental Sciences, Universiti Sains Malaysia, 16150 Kota Bharu, Kelantan, Malaysia. roselinda@kck.usm.my
Ahmad
Azlina
A
Rahman
Zainal Ariff Abdul
ZA
Mokhtar
Khairani Idah
KI
Lah
Nik Ahmad Shah Nik
NA
Zilfalil
Bin Alwi
BA
Samsudin
Ab Rani
AR
D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002971:Cleft Lip / Q000235:genetics*; D002972:Cleft Palate / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007223:Infant; D008296:Malaysia; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D019914:Taq Polymerase / Q000235:genetics; D016211:Transforming Growth Factor alpha / Q000235:genetics*; D055815:Young Adult
D016211:Transforming Growth Factor alpha; D019914:Taq Polymerase