title: Continuous glucose monitoring: a review of biochemical perspectives and clinical use in type 1 diabetes.
abstract: Self-monitoring of blood glucose is a fundamental part of diabetes management. It is mandatory for tight glucose control. For the past 30 years, intermittent measurement of capillary blood glucose has been the method of choice for self-monitoring. The main disadvantage of such measurements is that they provide isolated glucose values which do not reflect variations occurring throughout the day and night. Hence systems monitoring blood glucose concentrations on a "continuous basis" have been developed. In clinical studies, different devices were shown to provide useful information on glycemic excursions in people with diabetes with sufficient accuracy. Thus, in clinical practice, this approach has also been shown to help in the medical management leading to a reduction in glycated hemoglobin and glycemic variability. However, because of lack of experience, this technology has yet to replace standard capillary blood glucose monitoring. In this paper, we review the biochemical perspectives of continuous glucose monitoring and its clinical use in type 1 diabetes.
authors.affiliation: Department of Paediatrics, CHU Sainte-Justine, University of Montreal, 3175 Côte Sainte Catherine, Montreal, Quebec, Canada H3T 1C5.
authors.forename: Céline M
authors.initials: CM
authors.lastname: Girardin
authors.forename: Céline
authors.initials: C
authors.lastname: Huot
authors.forename: Monique
authors.initials: M
authors.lastname: Gonthier
authors.forename: Edgard
authors.initials: E
authors.lastname: Delvin
mesh_terms: D001786:Blood Glucose / Q000032:analysis*; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis*; D006801:Humans; D018670:Monitoring, Ambulatory / Q000295:instrumentation* / Q000379:methods
chemical_list: D001786:Blood Glucose