Chest radiographic and CT manifestations of chronic granulomatous disease in adults.
OBJECTIVE
The purpose of this study was to describe the thoracic radiologic findings of chronic granulomatous disease in adults.


METHODS
We retrospectively analyzed the chest radiographic and CT findings in four adults with chronic granulomatous disease during five episodes of lower respiratory tract infection.


RESULTS
Chest radiographic findings included areas of consolidation (60%), diffuse reticulonodular opacities (40%), pleural effusion (20%), and pulmonary artery enlargement (20%). CT findings included areas of consolidation (60%), pulmonary nodules in a random distribution (60%), centrilobular nodules (60%), tree-in-bud opacities (40%), areas of scarring and traction bronchiectasis (100%), emphysematous changes (75%), areas of decreased attenuation and vascularity associated with air trapping on expiratory CT (50%), mediastinal and/or hilar lymphadenopathy (60%), pulmonary artery enlargement (50%), and pleural effusion (20%). Areas of consolidation and nodules were the most prominent findings and at histologic examination were found to be associated with infection or granulomatous inflammation.


CONCLUSIONS
The pulmonary radiologic findings of chronic granulomatous disease include consolidation, nodules, areas of scarring, traction bronchiectasis, emphysema, air trapping, mediastinal and hilar lymphadenopathy, pulmonary artery enlargement, and pleural effusion.
Godoy
Myrna C B
MC
Department of Radiology, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada. migbarco@gmail.com
Vos
Patrick M
PM
Cooperberg
Peter L
PL
Lydell
Carmen P
CP
Phillips
Peter
P
Müller
Nestor L
NL
D000328:Adult; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D018410:Pneumonia, Bacterial / Q000000981:diagnostic imaging*; D013902:Radiography, Thoracic / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*