Decreased nerve distribution in mixed venous-lymphatic malformation.
In order to investigate the nerve distribution in mixed venous-lymphatic malformations (MVLMs), 57 postoperative patients diagnosed with MVLMs of the tongue were selected. Immunohistochemistry staining for neurofilament (NF) was used to detect sensory nerve fibers. Distribution of NF in samples from MVLMs was compared with distribution of NF in normal tongue tissue, venous malformations, lymphatic malformations and venular malformations. Results showed that the number of NF-positive nerve fibers in MVLMs was comparable to that in venous malformations and lymphatic malformations. The number of nerve fibers in MVLMs was significantly lower than in normal tissues. NF distribution in MVLMs was not affected by the patient's age or the coexistence of infection. These data suggest that the decreased distribution of sensory nerve fibers in MVLMs may be involved in the pathogenesis of MVLM of the tongue.
Shen
S
S
Department of Oral and Maxillofacial Surgery, Affiliated Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai, PR China.
Zhao
Y
Y
Yang
W
W
Xu
L
L
Sun
Z
Z
Chen
X
X
Ji
T
T
Zhang
C
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000032:analysis; D002648:Child; D004396:Coloring Agents; D006801:Humans; D007150:Immunohistochemistry; D044148:Lymphatic Abnormalities / Q000473:pathology*; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009419:Nerve Tissue Proteins / Q000032:analysis; D009454:Neurofibrils / Q000473:pathology; D016900:Neurofilament Proteins / Q000032:analysis; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000032:analysis; D012189:Retrospective Studies; D009418:S100 Proteins / Q000032:analysis; D011984:Sensory Receptor Cells / Q000473:pathology; D014059:Tongue / Q000002:abnormalities* / Q000294:innervation; D040321:Vascular Endothelial Growth Factor Receptor-3 / Q000032:analysis; D054079:Vascular Malformations / Q000473:pathology*; D055815:Young Adult; D014841:von Willebrand Factor / Q000032:analysis
D018952:Antigens, CD34; D004396:Coloring Agents; D009419:Nerve Tissue Proteins; D016900:Neurofilament Proteins; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D009418:S100 Proteins; C066858:neurofilament protein NF 68; D014841:von Willebrand Factor; D040321:Vascular Endothelial Growth Factor Receptor-3