title: The first chemoselective tandem acylation of the Blaise reaction intermediate: a novel method for the synthesis of alpha-acyl-beta-enamino esters, key intermediate for pyrazoles.
abstract: The Blaise reaction intermediate, a zinc bromide complex of beta-enamino ester, could be activated in situ by addition of a stoichiometric or catalytic amount of n-BuLi to allow chemoselective tandem C2-acylation providing alpha-acyl-beta-enamino esters, which are valuable intermediates for the syntheses of tri- and tetrasubstituted pyrazoles.
authors.affiliation: Department of Chemistry and Nano Science (BK21), Ewha Womans University, Seoul, 120-750, Korea.
authors.forename: Yu Sung
authors.initials: YS
authors.lastname: Chun
authors.forename: Ki Kon
authors.initials: KK
authors.lastname: Lee
authors.forename: Young Ok
authors.initials: YO
authors.lastname: Ko
authors.forename: Hyunik
authors.initials: H
authors.lastname: Shin
authors.forename: Sang-gi
authors.initials: SG
authors.lastname: Lee