Role of extracellular factors in axon regeneration in the CNS: implications for therapy.
The glial scar that forms after an injury to the CNS contains molecules that are inhibitory to axon growth. Understanding of the mechanisms of inhibition has allowed the development of therapeutic strategies aimed at promoting axon regeneration. Promising results have been obtained in animal models, and some therapies are undergoing clinical trials. This offers great hope for achievement of functional recovery after CNS injury.
Gervasi
Noreen M
NM
Cambridge University Centre for Brain Repair, ED Adrian Building, Forvie Site, Robinson Way, Cambridge CB22PY, UK. nmg28@cam.ac.uk
Kwok
Jessica Cf
JC
Fawcett
James W
JW
D000818:Animals; D001369:Axons / Q000502:physiology*; D002490:Central Nervous System / Q000502:physiology*; D005110:Extracellular Space / Q000378:metabolism*; D006801:Humans; D009186:Myelin Sheath / Q000378:metabolism; D009416:Nerve Regeneration; D009422:Nervous System Diseases / Q000628:therapy*