Visualization of cerebrospinal fluid movement with spin labeling at MR imaging: preliminary results in normal and pathophysiologic conditions.
Institutional review board approval and informed consent were obtained for this study. This study was HIPAA compliant. The purpose of this study was to visualize the movement of cerebrospinal fluid (CSF) noninvasively by using an unenhanced magnetic resonance imaging technique. A time-spatial labeling inversion pulse (SLIP) technique was applied to label, or tag, CSF in a region of interest. The tagged CSF was clearly visualized at inversion times of 1500-4500 msec after pulse labeling in both intracranial and intraspinal compartments. Noninvasive visualization of CSF movement, including bulk and turbulent flow, in normal (n = 7) and altered (n = 2) physiologic conditions was possible by using the unenhanced time-SLIP technique.
Yamada
Shinya
S
Department of Neurosurgery, Tokai University at Oiso Hospital, Kanagawa, Japan.
Miyazaki
Mitsue
M
Kanazawa
Hitoshi
H
Higashi
Minako
M
Morohoshi
Yukuo
Y
Bluml
Stefan
S
McComb
J Gordon
JG
D000328:Adult; D016080:Arachnoid Cysts / Q000503:physiopathology*; D002555:Cerebrospinal Fluid / Q000502:physiology*; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D019047:Phantoms, Imaging; D013113:Spin Labels
D013113:Spin Labels