National addictions vigilance intervention and prevention program (NAVIPPRO): a real-time, product-specific, public health surveillance system for monitoring prescription drug abuse.
OBJECTIVE
The National Addictions Vigilance Intervention and Prevention Program (NAVIPPRO) is a scientific, comprehensive risk management program for scheduled therapeutics. NAVIPPRO provides post-marketing surveillance, signal detection, signal verification and prevention and intervention programs. Here we focus on one component of NAVIPPRO surveillance, the Addiction Severity Index-Multimedia Version (ASI-MV) Connect, a continuous, real-time, national data stream that assesses pharmaceutical abuse by patients entering substance abuse treatment by collecting product-specific, geographically-detailed information.


METHODS
We evaluate population characteristics for data collected through the ASI-MV Connect in 2007 and 2008 and assess the representativeness, geographic coverage, and timeliness of report of the data. Analyses based on 41,923 admissions to 265 treatment centers in 29 states were conducted on product-specific opioid abuse rates, source of drug, and route of administration.


RESULTS
ASI-MV Connect data revealed that 11.5% of patients reported abuse of at least one opioid analgesic product in the 30 days prior to entering substance abuse treatment; differences were observed among sub-populations of prescription opioid abusers, among products, and also within various geographic locations.


CONCLUSIONS
The ASI-MV Connect component of NAVIPPRO represents a potentially valuable data stream for post-marketing surveillance of prescription drugs. Analyses conducted with data obtained from the ASI-MV Connect allow for the characterization of product-specific and geospatial differences for drug abuse and can serve as a tool to monitor responses of the abuse population to newly developed "abuse deterrent" drug formulations. Additional data, evaluation, and comparison to other systems are important next steps in establishing NAVIPPRO as a comprehensive, post-marketing surveillance system for prescription drugs.
Butler
Stephen F
SF
Inflexxion, Inc., Newton, MA 02464-1594, USA. sfbutler@inflexxion.com
Budman
Simon H
SH
Licari
Andrea
A
Cassidy
Theresa A
TA
Lioy
Katherine
K
Dickinson
James
J
Brownstein
John S
JS
Benneyan
James C
JC
Green
Traci Craig
TC
Katz
Nathaniel
N
D003195:Computer Communication Networks; D004335:Drug and Narcotic Control / Q000331:legislation & jurisprudence / Q000379:methods; D006078:Government Programs; D006801:Humans; D055553:Prescription Drugs / Q000009:adverse effects*; D011358:Product Surveillance, Postmarketing / Q000706:statistics & numerical data*; D012308:Risk Management; D019966:Substance-Related Disorders / Q000453:epidemiology / Q000517:prevention & control / Q000628:therapy; D014481:United States
D055553:Prescription Drugs