Quality of life and brain damage after microsurgical clip occlusion or endovascular coil embolization for ruptured anterior communicating artery aneurysms: neuropsychological assessment.
OBJECTIVE
For anterior communicating artery (ACoA) aneurysms, endovascular coil embolization constitutes a safe alternative therapeutic procedure to microsurgical clip occlusion. The authors' aim in this study was to evaluate the quality of life (QOL), cognitive function, and brain structure damage after the treatment of ruptured ACoA aneurysms in a group of patients who underwent microsurgical clipping (36 patients) compared with a reference group who underwent endovascular coiling (14 patients).


METHODS
At 14 months posttreatment all patients underwent evaluations by independent observers. These observers evaluated global efficacy, executive functions using a frontal assessment battery of tests (Trail making test, Stroop tasks, dual task of Baddeley, verbal fluency, and Wisconsin Card Sorting test), behavior dysexecutive syndrome (the Inventaire du Syndrome Dysexécutif Comportemental questionnaire [ISDC]), and QOL by using the Reintegration To Normal Living Index. Brain damage was analyzed using MR imaging.


RESULTS
In the microsurgical clipping and endovascular coiling groups, the distribution on the modified Rankin Scale (p = 0.19) and mean QOL score (85.4 vs 83.4, respectively) were similar. Moreover, the proportion of executive dysfunctions (19.4 vs 28.6%, respectively) and the mean score on the ISDC questionnaire (8.9 vs 8.5, respectively) were not significant, but verbal memory was more altered in the microsurgical clipping group (p = 0.055). Magnetic resonance imaging revealed that the incidence of local encephalomalacia and the median number of lesions per patient increased significantly in the microsurgical clipping group (p = 0.003).


CONCLUSIONS
In the 2 groups, no significant difference was observed regarding QOL, executive functions, and behavior. Despite the significant decrease in verbal memory after microsurgical clipping, the interdisciplinary approach remains a safe and useful strategy.
Proust
François
F
Departments of Neurosurgery, Rouen University Hospital, Rouen, France. Francois.Proust@chu-rouen.fr
Martinaud
Olivier
O
Gérardin
Emmanuel
E
Derrey
Stéphane
S
Levèque
Sophie
S
Bioux
Sandrine
S
Tollard
Eléonore
E
Clavier
Erick
E
Langlois
Olivier
O
Godefroy
Olivier
O
Hannequin
Didier
D
Fréger
Pierre
P
D000368:Aged; D017542:Aneurysm, Ruptured / Q000601:surgery*; D001007:Anxiety / Q000209:etiology / Q000523:psychology; D001925:Brain Damage, Chronic / Q000209:etiology* / Q000523:psychology*; D002548:Cerebral Revascularization; D015331:Cohort Studies; D003863:Depression / Q000209:etiology / Q000523:psychology; D004621:Embolization, Therapeutic; D005260:Female; D005500:Follow-Up Studies; D023261:Glasgow Outcome Scale; D006801:Humans; D002532:Intracranial Aneurysm / Q000601:surgery*; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D001523:Mental Disorders / Q000209:etiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D011446:Prospective Studies; D011788:Quality of Life; D013345:Subarachnoid Hemorrhage / Q000150:complications / Q000601:surgery; D014057:Tomography, X-Ray Computed