Effect of Commiphora mukul extract on cardiac dysfunction and ventricular function in isoproterenol-induced myocardial infarction.
In present study, hydroalcoholic extract of C. mukul significantly improved the cardiac function and prevented myocardial ischemic impairment manifested in the form of increased heart rate, decreased arterial pressure, increased left ventricular end diastolic pressure, and altered myocardial contractility indices. C. mukul treatment additionally also produced a significant increase in lactate dehydrogenase levels and prevented decline of protein content in heart. C. mukul preserved the structural integrity of myocardium. Reduced leakage of myocyte enzyme lactate dehydrogenase and maintenance of structural integrity of myocardium along with favorable modulation of cardiac function and improved cardiac performance indicate the salvage of myocardium with C. mukul treatment. Guggulsterones which are considered to be responsible for most of the therapeutic properties of C. mukul may underlie the observed cardioprotective effect of C. mukul against cardiac dysfunction in isoproterenol-induced ischemic rats.
Ojha
Shreesh K
SK
Cardiovascular Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi 110 029, India.
Nandave
Mukesh
M
Arora
Sachin
S
Mehra
Raj D
RD
Joshi
Sujata
S
Narang
Rajiv
R
Arya
D S
DS
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D029744:Commiphora / Q000737:chemistry*; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology*; D010936:Plant Extracts / Q000737:chemistry* / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D016276:Ventricular Function / Q000187:drug effects*
D010936:Plant Extracts; D007545:Isoproterenol