[Can the hyperactivity of lipogenesis cause hepatic steatosis? A role for ChREBP].
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease associated with insulin resistance, obesity and type 2 diabetes. Excessive accumulation of triglycerides (TG) is a hallmark of NAFLD and therefore, a better understanding of the steps involved in regulating hepatic TG synthesis might yield novel information regarding the prevention and treatment of NAFLD. In the recent years, the transcription factor ChRepsilonBP has emerged as a major mediator of glucose action on lipogenic genes and as a key determinant of lipid synthesis in vitro. More importantly, this factor has been described to play a central role in hepatic steatosis and insulin resistance physiopathology. Although its implication in human disease has not yet been demonstrated, ChRepsilonBP could be an interesting therapeutic target against metabolic syndrome components.
Robichon
Céline
C
Institut Cochin, Département d'Endocrinologie, Métabolisme et Cancer, Université Paris Descartes, CNRS (UMR 8104), Paris, France. robichon@cochin.inserm.fr
Girard
Jean
J
Postic
Catherine
C
D000818:Animals; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000502:physiology*; D005227:Fatty Acids / Q000378:metabolism; D005234:Fatty Liver / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D005947:Glucose / Q000378:metabolism; D006019:Glycolysis / Q000235:genetics / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000502:physiology; D007333:Insulin Resistance / Q000235:genetics / Q000502:physiology; D050155:Lipogenesis / Q000235:genetics / Q000502:physiology*; D008099:Liver / Q000378:metabolism; D024821:Metabolic Syndrome / Q000235:genetics / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D008820:Mice, Obese; D009687:Nuclear Proteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D051780:Sterol Regulatory Element Binding Protein 1 / Q000502:physiology; D014157:Transcription Factors / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D015533:Transcriptional Activation; D014280:Triglycerides / Q000378:metabolism
D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D005227:Fatty Acids; D007328:Insulin; C116385:MLXIPL protein, human; C506001:Mlxipl protein, mouse; D009687:Nuclear Proteins; C497388:Srebf1 protein, mouse; D051780:Sterol Regulatory Element Binding Protein 1; D014157:Transcription Factors; D014280:Triglycerides; D005947:Glucose