title: Air-stable and phosphine-free iridium catalysts for highly enantioselective hydrogenation of quinoline derivatives.
abstract: Enantioselective hydrogenation of quinoline derivatives catalyzed by phosphine-free chiral cationic Cp*Ir(OTf)(CF 3TsDPEN) complex (CF 3TsDPEN = N-(p-trifluoromethylbenzenesulfonyl)-1,2-diphenylethylene-diamine) afforded the 1,2,3,4-tetrahydroquinoline derivatives in up to 99% ee. The reaction could be carried out with a substrate-to-catalyst molar ratio as high as 1000 in undegassed methanol and with no need for inert gas protection.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Center for Chemical Biology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Li
authors.forename: Tian-Li
authors.initials: TL
authors.lastname: Wang
authors.forename: Yan-Mei
authors.initials: YM
authors.lastname: He
authors.forename: Zhi-Jian
authors.initials: ZJ
authors.lastname: Wang
authors.forename: Qing-Hua
authors.initials: QH
authors.lastname: Fan
authors.forename: Jie
authors.initials: J
authors.lastname: Pan
authors.forename: Li-Jin
authors.initials: LJ
authors.lastname: Xu
mesh_terms: D000388:Air; D002384:Catalysis; D006865:Hydrogenation; D007495:Iridium / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry; D011804:Quinolines / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D010720:Phosphines; D011804:Quinolines; D007495:Iridium; C037219:quinoline; C044646:phosphine