title: Size dependent heat generation of magnetite nanoparticles under AC magnetic field for cancer therapy.
abstract: BACKGROUND
  We have developed magnetic cationic liposomes (MCLs) that contained magnetic nanoparticles as heating mediator for applying them to local hyperthermia. The heating performance of the MCLs is significantly affected by the property of the incorporated magnetite nanoparticles. We estimated heating capacity of magnetite nanoparticles by measuring its specific absorption rate (SAR) against irradiation of the alternating magnetic field (AMF).
  
  
  METHODS
  Magnetite nanoparticles which have various specific-surface-area (SSA) are dispersed in the sample tubes, subjected to various AMF and studied SAR.
  
  
  RESULTS
  Heat generation of magnetite particles under variable AMF conditions was summarized by the SSA. There were two maximum SAR values locally between 12 m2/g to 190 m2/g of the SSA in all ranges of applied AMF frequency and those values increased followed by the intensity of AMF power. One of the maximum values was observed at approximately 90 m2/g of the SSA particles and the other was observed at approximately 120 m2/g of the SSA particles. A boundary value of the SAR for heat generation was observed around 110 m2/g of SSA particles and the effects of the AMF power were different on both hand. Smaller SSA particles showed strong correlation of the SAR value to the intensity of the AMF power though larger SSA particles showed weaker correlation.
  
  
  CONCLUSIONS
  Those results suggest that two maximum SAR value stand for the heating mechanism of magnetite nanoparticles represented by hysteresis loss and relaxation loss.
authors.affiliation: Department of Biotechnology, School of Engineering, Nagoya University, Furo-cho, Nagoya 464-8603, Japan. jun.motoyama@nipponkayaku.co.jp
authors.forename: Jun
authors.initials: J
authors.lastname: Motoyama
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Hakata
authors.forename: Ryuji
authors.initials: R
authors.lastname: Kato
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Yamashita
authors.forename: Tomio
authors.initials: T
authors.lastname: Morino
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Honda