UCbase & miRfunc: a database of ultraconserved sequences and microRNA function.
Four hundred and eighty-one ultraconserved sequences (UCRs) longer than 200 bases were discovered in the genomes of human, mouse and rat. These are DNA sequences showing 100% identity among the three species. UCRs are frequently located at genomic regions involved in cancer, differentially expressed in human leukemias and carcinomas and in some instances regulated by microRNAs (miRNAs). Here we present UCbase & miRfunc, the first database which provides ultraconserved sequences data and shows miRNA function. Also, it links UCRs and miRNAs with the related human disorders and genomic properties. The current release contains over 2000 sequences from three species (human, mouse and rat). As a web application, UCbase & miRfunc is platform independent and it is accessible at http://microrna.osu.edu/.UCbase4.
Taccioli
Cristian
C
Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA.
Fabbri
Enrica
E
Visone
Rosa
R
Volinia
Stefano
S
Calin
George A
GA
Fong
Louise Y
LY
Gambari
Roberto
R
Bottoni
Arianna
A
Acunzo
Mario
M
Hagan
John
J
Iorio
Marilena V
MV
Piovan
Claudia
C
Romano
Giulia
G
Croce
Carlo Maria
CM
D000818:Animals; D001483:Base Sequence; D017124:Conserved Sequence; D004247:DNA / Q000737:chemistry*; D030561:Databases, Nucleic Acid; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000737:chemistry / Q000378:metabolism*; D051381:Rats; D014584:User-Computer Interface
D035683:MicroRNAs; D004247:DNA