title: Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance.
authors.forename: Caroline
authors.initials: C
authors.lastname: Wehmeier
authors.forename: Sabine
authors.initials: S
authors.lastname: Schuster
authors.forename: Eva
authors.initials: E
authors.lastname: Fähnrich
authors.forename: Winfried V
authors.initials: WV
authors.lastname: Kern
authors.forename: Jürgen A
authors.initials: JA
authors.lastname: Bohnert
mesh_terms: D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics* / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D018942:Macrolides / Q000494:pharmacology*; D008969:Molecular Sequence Data; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D016297:Mutagenesis, Site-Directed / Q000379:methods*; D017386:Sequence Homology, Amino Acid
chemical_list: D000900:Anti-Bacterial Agents; D029968:Escherichia coli Proteins; D018942:Macrolides; D027425:ATP-Binding Cassette, Sub-Family C Proteins; C083496:AcrB protein, E coli