title: Association between corneal hysteresis and central corneal thickness in glaucomatous and non-glaucomatous eyes.
abstract: OBJECTIVE
  We aimed to determine corneal hysteresis values (CH) using the ocular response analyser (ORA) in non-glaucomatous and glaucomatous eyes and their relationship with central corneal thickness (CCT).
  
  
  METHODS
  Corneal hysteresis, intraocular pressure (IOP) as measured by Goldmann applanation tonometry (GAT) and CCT were prospectively evaluated in 74 non-glaucoma subjects with IOP < 21 mmHg and in 108 patients with treated primary open-angle glaucoma (POAG). One eye in each subject was randomly selected for inclusion in the analysis.
  
  
  RESULTS
  Mean (+/- standard deviation [SD]) age was 59.2 +/- 14.2 years in the non-glaucoma group and 62.4 +/- 9.8 years in the glaucoma group. Mean (+/- SD) GAT IOP was 15.7 +/- 2.65 mmHg and 16.38 +/- 2.73 mmHg in the non-glaucoma and glaucoma groups, respectively. There was no statistically significant difference between the two groups in mean age (p = 0.396) or mean GAT IOP (p = 0.098). Mean (+/- SD) CH was 10.97 +/- 1.59 mmHg in the non-glaucoma and 8.95 +/- 1.27 mmHg in the glaucoma groups, respectively. The difference in mean CH between the two groups was statistically significant (p < 0.0001). There was a strong positive correlation between CH and CCT in the non-glaucoma group (r = 0.743) and a significantly (p = 0.001) weaker correlation (r = 0.426) in the glaucoma group.
  
  
  CONCLUSIONS
  Corneal hysteresis was significantly lower in eyes with treated POAG than in non-glaucomatous eyes. The corneal biomechanical response was strongly associated with CCT in non-glaucoma subjects, but only moderately so in glaucoma patients. It can be assumed that diverse structural factors, in addition to thickness, determine the differences in the corneal biomechanical profile between non-glaucomatous and glaucomatous eyes. Corneal hysteresis could be a useful tool in the diagnosis of glaucoma.
authors.affiliation: Glaucoma Department, Eye Clinic, Hellenic Red Cross General Hospital, Athens, Greece. maguritsas@vodafone.net.gr
authors.forename: George
authors.initials: G
authors.lastname: Mangouritsas
authors.forename: George
authors.initials: G
authors.lastname: Morphis
authors.forename: Spyridon
authors.initials: S
authors.lastname: Mourtzoukos
authors.forename: Elias
authors.initials: E
authors.lastname: Feretis
mesh_terms: D000328:Adult; D000368:Aged; D003315:Cornea / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D004548:Elasticity; D005260:Female; D005902:Glaucoma, Open-Angle / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009885:Ophthalmology / Q000295:instrumentation; D011446:Prospective Studies; D014463:Ultrasonography; D014783:Viscosity