title: No association found between the promoter variations of QKI and schizophrenia in the Chinese population.
abstract: BACKGROUND
  Schizophrenia is a chronic psychiatric disorder with a strong genetic component. Several recent published studies have reported that the mRNA expression level of quaking homolog, KH domain RNA binding (QKI) is down regulated in individuals diagnosed with schizophrenia.
  
  
  METHODS
  We were interested in the genetic variants around the promoter region of QKI and selected seven variants in this region, namely rs4263561, rs3904720, rs387504, rs3763197, rs7772756, rs7758706 and rs4709716. For the study we recruited 288 individuals diagnosed with schizophrenia and 288 control subjects. All the recruits were from Shanghai and were Han Chinese in origin.
  
  
  RESULTS
  No individual SNP nor any haplotype was found to be associated with schizophrenia.
  
  
  CONCLUSIONS
  These results suggest that the variants within the promoter region of QKI gene are unlikely to play a major role in susceptibility to schizophrenia in the Chinese population.
authors.affiliation: Institute of Neuropsychiatric Science and Systems Biological Medicine, Shanghai Jiao Tong University, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Huang
authors.forename: Wei
authors.initials: W
authors.lastname: Tang
authors.forename: Zhao
authors.initials: Z
authors.lastname: Xu
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Li
authors.forename: Zhangdong
authors.initials: Z
authors.lastname: He
authors.forename: Ruqi
authors.initials: R
authors.lastname: Tang
authors.forename: Ronglin
authors.initials: R
authors.lastname: Che
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Xu
authors.forename: Xingwang
authors.initials: X
authors.lastname: Li
authors.forename: Guoyin
authors.initials: G
authors.lastname: Feng
authors.forename: Lin
authors.initials: L
authors.lastname: He
authors.forename: Yongyong
authors.initials: Y
authors.lastname: Shi
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D016601:RNA-Binding Proteins / Q000235:genetics*; D012307:Risk Factors; D012559:Schizophrenia / Q000235:genetics*
chemical_list: C490832:QKI protein, human; D016601:RNA-Binding Proteins