Cutting edge: local recall responses by memory T cells newly recruited to peripheral nonlymphoid tissues.
Infection results in the formation of a circulating effector memory T cell population able to enter peripheral tissues either in the steady state or in response to localized infection. As a consequence, recall is thought to result from a phased response first involving those T cells already at the site of infection followed by the infiltration of memory cells from the wider circulation. We have recently reported that tissue-resident T cells can undergo stimulation and proliferation in response to local infection. In this study, we examine the proliferation of memory T cells newly recruited from the circulation. Our results show that although recruitment of circulating memory cells is nonspecific in nature, there is preferential proliferation of specific T cells within infected tissues. Thus, expansion represents a means of local Ag-specific enrichment of T cells recruited from a circulating memory pool of mixed specificities.
Wakim
Linda M
LM
Department of Microbiology and Immunology, University of Melbourne, Melbourne, Australia.
Gebhardt
Thomas
T
Heath
William R
WR
Carbone
Francis R
FR
D000818:Animals; D002449:Cell Aggregation / Q000276:immunology; D002454:Cell Differentiation / Q000276:immunology; D002465:Cell Movement / Q000276:immunology*; D049109:Cell Proliferation; D018984:Epitopes, T-Lymphocyte / Q000378:metabolism; D005727:Ganglia, Spinal / Q000166:cytology / Q000276:immunology / Q000821:virology; D006561:Herpes Simplex / Q000276:immunology / Q000517:prevention & control / Q000821:virology; D018259:Herpesvirus 1, Human / Q000276:immunology; D007156:Immunologic Memory; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology / Q000637:transplantation; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology* / Q000821:virology*
D018984:Epitopes, T-Lymphocyte