title: Hepcidin, an antimicrobial peptide is downregulated in ceruloplasmin-deficient mice.
abstract: Hepcidin, a principle regulator of iron metabolism, is synthesized by the liver. Contradictory results have been reported on the regulation of hepcidin expression in response to serum transferrin saturation and liver iron content. In the present study, we explore the expression of murine hepcidin mRNA and further analyze the relationship between liver hepcidin mRNA expression, liver iron stores, and serum iron level utilizing ceruloplasmin gene knockout mice. We find that hepcidin expression correlates significantly with serum transferrin saturation, whereas there is a negative correlation of hepcidin expression with liver tissue iron level.
authors.affiliation: Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang 050016, Hebei Province, People's Republic of China.
authors.forename: Pei
authors.initials: P
authors.lastname: Guo
authors.forename: Rui
authors.initials: R
authors.lastname: Cui
authors.forename: Yan-Zhong
authors.initials: YZ
authors.lastname: Chang
authors.forename: Wen-Shuang
authors.initials: WS
authors.lastname: Wu
authors.forename: Zhong-Ming
authors.initials: ZM
authors.lastname: Qian
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Yoshida
authors.forename: Ya-Tiao
authors.initials: YT
authors.lastname: Qiao
authors.forename: Shin'ichi
authors.initials: S
authors.lastname: Takeda
authors.forename: Xiang-Lin
authors.initials: XL
authors.lastname: Duan
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000378:metabolism*; D023181:Antimicrobial Cationic Peptides / Q000235:genetics* / Q000378:metabolism; D002570:Ceruloplasmin / Q000235:genetics* / Q000378:metabolism; D015536:Down-Regulation / Q000235:genetics*; D005838:Genotype; D064451:Hepcidins; D007501:Iron / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D010641:Phenotype; D012333:RNA, Messenger / Q000378:metabolism; D014168:Transferrin / Q000378:metabolism
chemical_list: D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides; C579599:Hamp protein, mouse; D064451:Hepcidins; D012333:RNA, Messenger; D014168:Transferrin; D007501:Iron; D002570:Ceruloplasmin