Attenuation of morphine withdrawal signs by low level laser therapy in rats.
In the present study, the effects of low-intensity laser therapy (LILT) on naloxone-induced withdrawal signs of morphine-dependent rats were examined. Low-intensity lasers with a power density of 12.5J/cm(2) have been used by a Ga-Al-As laser. One-way ANOVA showed that the LILT which applied immediately or 15min prior to naloxone injection significantly decreased total withdrawal score (TWS). These results suggest that LILT prior to naloxone injection attenuates the expression of withdrawal signs in morphine-dependent rats. Further studies may elucidate the likely role of LILT in clinical management of opioid withdrawal syndrome.
Mirzaii-Dizgah
Iraj
I
Department of Physiology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran. emirzaii@razi.tums.ac.ir
Ojaghi
Reza
R
Sadeghipour
H R
HR
Sadeghipour-Roodsari
Hamid Reza
HR
Karimian
Seyed Morteza
SM
Sohanaki
Hamid
H
D000701:Analgesics, Opioid; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003627:Data Interpretation, Statistical; D028022:Low-Level Light Therapy; D008297:Male; D009020:Morphine; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013375:Substance Withdrawal Syndrome / Q000628:therapy*
D000701:Analgesics, Opioid; D009292:Narcotic Antagonists; D009270:Naloxone; D009020:Morphine