title: Dietary habits and prostate cancer detection: a case-control study.
abstract: BACKGROUND
  Many studies have suggested that nutritional factors may affect prostate cancer development. The aim of our study was to evaluate the relationship between dietary habits and prostate cancer detection.
  
  
  METHODS
  We studied 917 patients who planned to have transrectal ultrasonography-guided prostatic biopsy based on an elevated serum prostate-specific antigen (PSA) level, a rising serum PSA level or an abnormal digital rectal examination. Before receiving the results of their biopsy, all patients answered a self-administered food frequency questionnaire. In combination with pathology data we performed univariable and multivariable logistic regression analyses for the predictors of cancer and its aggressiveness.
  
  
  RESULTS
  Prostate cancer was found in 42% (386/917) of patients. The mean patient age was 64.5 (standard deviation [SD] 8.3) years and the mean serum PSA level for prostate cancer and benign cases, respectively, was 13.4 (SD 28.2) mug/L and 7.3 (SD 4.9) mug/L. Multivariable analysis revealed that a meat diet (e.g., red meat, ham, sausages) was associated with an increased risk of prostate cancer (odds ratio [OR] 2.91, 95% confidence interval [CI] 1.55-4.87, p = 0.027) and a fish diet was associated with less prostate cancer (OR 0.54, 95% CI 0.32-0.89, p = 0.017). Aggressive tumours were defined by Gleason score (>/= 7), serum PSA level (>/= 10 mug/L) and the number of positive cancer cores (>/= 3). None of the tested dietary components were found to be associated with prostate cancer aggressivity.
  
  
  CONCLUSIONS
  Fish diets appear to be associated with less risk of prostate cancer detection, and meat diets appear to be associated with a 3-fold increased risk of prostate cancer. These observations add to the growing body of evidence suggesting a relationship between diet and prostate cancer risk.
authors.affiliation: Division of Urology, Department of Surgery, McGill University Health Centre, Montréal, Que.
authors.forename: Moamen
authors.initials: M
authors.lastname: Amin
authors.forename: Suganthiny
authors.initials: S
authors.lastname: Jeyaganth
authors.forename: Nader
authors.initials: N
authors.lastname: Fahmy
authors.forename: Louis R
authors.initials: LR
authors.lastname: Bégin
authors.forename: Samuel
authors.initials: S
authors.lastname: Aronson
authors.forename: Stephen
authors.initials: S
authors.lastname: Jacobson
authors.forename: Simon
authors.initials: S
authors.lastname: Tanguay
authors.forename: Wassim
authors.initials: W
authors.lastname: Kassouf
authors.forename: Armen
authors.initials: A
authors.lastname: Aprikian