Metal free thiol-maleimide 'Click' reaction as a mild functionalisation strategy for degradable polymers.
The stoichiometric reaction between thiols and maleimide-functional poly(ester)s is demonstrated to be a quantitative, tolerant, mild and efficient method for polymer modification.
Pounder
Ryan J
RJ
Department of Chemistry, University of Warwick, Coventry, UKCV4 7AL.
Stanford
Matthew J
MJ
Brooks
Paul
P
Richards
Stephen P
SP
Dove
Andrew P
AP
D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008301:Maleimides / Q000737:chemistry*; D008670:Metals / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013438:Sulfhydryl Compounds / Q000737:chemistry*
D007202:Indicators and Reagents; D008301:Maleimides; D008670:Metals; D011108:Polymers; D013438:Sulfhydryl Compounds