SH3BP2 is a critical regulator of macrophage and osteoclast response to M-CSF and RANKL stimulation.
The protein Src homology 3 domain-binding protein 2 (SH3BP2) is a regulator of tumor necrosis factor (TNF)-alpha generation in macrophages and of osteoclast differentiation. SH3BP2 regulates bone marrow monocyte responses to macrophage and osteoclast differentiation signals downstream of the receptors for macrophage colony-stimulating factor and receptor activator of nuclear factor kappaB ligand. SH3BP2 is a potential target for the development of novel anti-TNF-alpha therapeutic interventions as well as a target for suppression of osteoclastogenesis.
McMahon
Mark S
MS
Department of Orthopedic Surgery, Beth Israel Deaconess Medical Center, 330 Brookline Ave., Boston, MA 02215, USA. msmcmahon@att.net
Ueki
Yasuyoshi
Y