Genetic characterization of measles viruses in China, 2004.
Genetic characterization of wild-type measles virus was studied using nucleotide sequencing of the C-terminal region of the N protein gene and phylogenetic analysis on 59 isolates from 16 provinces of China in 2004. The results showed that all of the isolates belonged to genotype H1. 51 isolates were belonged to cluster 1 and 8 isolates were cluster 2 and Viruses from both clusters were distributed throughout China without distinct geographic pattern. The nucleotide sequence and predicted amino acid homologies of the 59 H1 strains were 96.5%-100% and 95.7%-100%, respectively. The report showed that the transmission pattern of genotype H1 viruses in China in 2004 was consistent with ongoing endemic transmission of multiple lineages of a single, endemic genotype. Multiple transmission pathways leaded to multiple lineages within endemic genotype.
Zhang
Yan
Y
WHO WPRO Regional Reference Measles Lab, National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Beijing 100050, PR China. zhangyanft@hotmail.com
Ji
Yixin
Y
Jiang
Xiaohong
X
Xu
Songtao
S
Zhu
Zhen
Z
Zheng
Lei
L
He
Jilan
J
Ling
Hua
H
Wang
Yan
Y
Liu
Yang
Y
Du
Wen
W
Yang
Xuelei
X
Mao
Naiying
N
Xu
Wenbo
W
D002681:China / Q000453:epidemiology; D016000:Cluster Analysis; D019353:Endemic Diseases; D006801:Humans; D008457:Measles / Q000453:epidemiology* / Q000635:transmission / Q000821:virology*; D008459:Measles virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D019590:Nucleocapsid Proteins; D009698:Nucleoproteins / Q000235:genetics; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D014764:Viral Proteins / Q000235:genetics
D019590:Nucleocapsid Proteins; D009698:Nucleoproteins; D014764:Viral Proteins; C058314:nucleoprotein, Measles virus