Systemic lupus erythematosus associated with extreme hypertriglyceridemia.
Only a few cases of hypertriglyceridemia in patients with systemic lupus erythematosus (SLE) have been reported. We report a case of a 13-year-old girl suffering from SLE associated with severe hypertriglyceridemia. The persistent hypertriglyceridemia was extremely well tolerated. As a result of steroid treatment, serum triglycerides fell dramatically from a high of 5601 mg/dL to 75 mg/dL despite the patient switching to a free diet. We considered the presence of an autoantibody to lipoprotein lipase and commenced immunosuppression. The role of steroids in completely correcting deficient lipoprotein lipase activity is discussed.
Huang
Chin-Sung
CS
Department of Pediatrics, Taipei City Hospital Ren-Ai Branch, Taipei, Taiwan.
Wu
Wei-Fong
WF
D000293:Adolescent; D002914:Chylomicrons / Q000097:blood; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000209:etiology*; D008071:Lipoprotein Lipase / Q000172:deficiency; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use
D002914:Chylomicrons; D011239:Prednisolone; D008071:Lipoprotein Lipase