title: Understanding the mechanism of Pd-catalyzed allylic substitution of the cyclic difluorinated carbonates.
abstract: We present a mechanistic investigation of Pd-catalyzed allylic substitution of cyclic gem-difluorinated carbonates 1 and 4, previously employed in the synthesis of 3',3'-difluoro-2'-hydroxymethyl-4',5'-unsaturated carbocyclic nucleosides in 17 steps. The substitution features a reversal of regioselectivity caused by fluorine.
authors.affiliation: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China. xujun@mail.sioc.ac.cn
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.forename: Xiao-Long
authors.initials: XL
authors.lastname: Qiu
authors.forename: Feng-Ling
authors.initials: FL
authors.lastname: Qing