MITAgating viral infection.
Two recent papers, one in this issue of Immunity (Zhong et al., 2008), report the identification of a membrane protein, termed MITA or STING, that activates the transcription factor IRF3 to induce type-I interferons to mitigate viral infection.
Zeng
Wenwen
W
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Chen
Zhijian J
ZJ
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D050838:Interferon Regulatory Factor-3 / Q000378:metabolism; D007370:Interferon Type I / Q000276:immunology / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D011494:Protein Kinases / Q000378:metabolism; D017434:Protein Structure, Tertiary; D020365:RNA Helicases / Q000378:metabolism*; D012367:RNA, Viral / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000276:immunology / Q000378:metabolism*; D014777:Virus Diseases / Q000276:immunology* / Q000378:metabolism
D048868:Adaptor Proteins, Signal Transducing; D050838:Interferon Regulatory Factor-3; D007370:Interferon Type I; D008565:Membrane Proteins; D012367:RNA, Viral; D051193:Toll-Like Receptors; D011494:Protein Kinases; D020365:RNA Helicases