[The role of nuclear receptors in cell death].
The nuclear receptors form a group of structurally homologous proteins which act as ligand-dependent transcription factors and regulate a variety of intracellular processes. The nuclear receptors act as monomomers, homodimers, or heterodimers together with retinoid X receptor (RXR). They bind in the nucleus to a specific nucleotide sequence in the promoter region called the response element (RE). Certain nuclear receptors (e.g. Nur77, GR, RXR, RAR, VDR, PPAR) can influence apoptosis through the induction of pro- and/or anti-apoptotic proteins or affect other transcription factors. Some ligands for the nuclear receptors (mainly retinoids) are applied in anticancer therapy alone or in combination with other anticancer drugs.
Kopij
Magdalena
M
Laboratorium Immunobiologii Molekularnej Nowotworów, Instytut Immunologii i Terapii Doświadczalnej PAN im. Ludwika Hirszfelda we Wrocławiu.
Rapak
Andrzej
A
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D018160:Receptors, Cytoplasmic and Nuclear / Q000145:classification / Q000187:drug effects / Q000378:metabolism*; D020218:Response Elements / Q000502:physiology; D047488:Retinoid X Receptors / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
D000970:Antineoplastic Agents; D018160:Receptors, Cytoplasmic and Nuclear; D047488:Retinoid X Receptors; D014157:Transcription Factors