OPT-80 eliminates Clostridium difficile and is sparing of bacteroides species during treatment of C. difficile infection.
During a 10-day treatment for Clostridium difficile infection, OPT-80 and vancomycin were comparably effective in reducing C. difficile counts. Bacteroides fragilis group counts appeared unaffected with increasing dosages of OPT-80, whereas vancomycin was markedly suppressive. Retention of components of the normal microflora might lower the risk of recurrent disease.
Louie
Thomas J
TJ
Department of Medicine, Division of Infectious Diseases, University of Calgary, Calgary, Alberta, Canada. thomas.louie@calgaryhealthregion.ca
Emery
Judy
J
Krulicki
Walter
W
Byrne
Brendan
B
Mah
Manuel
M
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001439:Bacteroides / Q000187:drug effects*; D016360:Clostridioides difficile / Q000187:drug effects*; D003015:Clostridium Infections / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D006027:Glycosides / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D014640:Vancomycin / Q000008:administration & dosage / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D006027:Glycosides; C487655:OPT 80; D014640:Vancomycin