[Pathophysiological mechanisms of hemorrhagic stroke and the ways of differential therapy].
The changes developing in the perifocal area of hematoma and perspectives of antioxidant and chelate therapy were studied on the model of experimental hemorrhagic stroke and in clinical conditions. Microcirculatory, ischemic and inflammation disturbances with a certain time sequence were found in the perifocal areas. These changes, along with hypostasis and oxidative stress, form the pathobiochemical cascade of changes in hemorrhagic stroke and are potential therapeutic targets. Administering of an antioxidant and chelate drug histochrome reduces the intensity of changes in the perifocal area in the experimental conditions. In clinical conditions, it accelerates the dynamics of brain and meningeal symptoms regression and improves the blood rheological properties.
Gusev
E I
EI
Stonik
V A
VA
Martynov
M Iu
MIu
Guseva
M R
MR
Shchukin
I A
IA
Diuĭzen
I V
IV
Koplik
E V
EV
Mishchenko
N P
NP
Agafonova
I G
IG
Kolesnikova
T I
TI
Fedoreev
S A
SA
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002545:Brain Ischemia / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D002543:Cerebral Hemorrhage / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D002614:Chelating Agents / Q000627:therapeutic use*; D008297:Male; D009285:Naphthoquinones / Q000627:therapeutic use*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D002614:Chelating Agents; D009285:Naphthoquinones; D010975:Platelet Aggregation Inhibitors; C103614:histochrome