CNTRICS final task selection: long-term memory.
Long-term memory (LTM) is a multifactorial construct, composed of different stages of information processing and different cognitive operations that are mediated by distinct neural systems, some of which may be more responsible for the marked memory problems that limit the daily function of individuals with schizophrenia. From the outset of the CNTRICS initiative, this multidimensionality was appreciated, and an effort was made to identify the specific memory constructs and task paradigms that hold the most promise for immediate translational development. During the second CNTRICS meeting, the LTM group identified item encoding and retrieval and relational encoding and retrieval as key constructs. This article describes the process that the LTM group went through in the third and final CNTRICS meeting to select nominated tasks within the 2 LTM constructs and within a reinforcement learning construct that were judged most promising for immediate development. This discussion is followed by each nominating authors' description of their selected task paradigm, ending with some thoughts about future directions.
Ragland
John D
JD
Department of Psychiatry and Behavioral Sciences, University of California at Davis, Sacramento, CA 95817, USA. jdragland@ucdavis.edu
Cools
Roshan
R
Frank
Michael
M
Pizzagalli
Diego A
DA
Preston
Alison
A
Ranganath
Charan
C
Wagner
Anthony D
AD
D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000503:physiopathology; D002755:Choice Behavior; D006801:Humans; D008279:Magnetic Resonance Imaging; D008569:Memory Disorders / Q000175:diagnosis / Q000209:etiology*; D009415:Nerve Net / Q000503:physiopathology; D009483:Neuropsychological Tests; D011594:Psychometrics; D012559:Schizophrenia / Q000150:complications* / Q000503:physiopathology