title: Teratogenic effects in mouse fetuses subjected to the concurrent in utero exposure to miconazole and metronidazole.
abstract: The potential interactivity of the antimicrobials miconazole and metronidazole in the induction of teratogenic effects was investigated in the present study. Drugs were injected at 60 mg/kg either individually or in combination to pregnant mice on gestation day (GD) 8, 9, or 10. Teratological assessments were carried out on GD 18. A potent teratogenic interaction resulted from miconazole-metronidazole co-administration, causing an increment in axial skeletal defects incidence. While, the individual exposure to miconazole or metronidazole produced axial skeletal defects at frequencies that did not exceed 5.6% in the various treatment groups, the percentage of fetuses with malformed skeleton reached 26% after co-exposure on GD 8 or GD 9. No significant synergism was noted when drugs were co-administered on GD 10. This study shows that a teratogenic interaction can result from miconazole-metronidazole concomitant exposure.
authors.affiliation: Sezione di Ostetricia e Ginecologia, Dipartimento di Medicina e Scienze dell'Invecchiamento, Facoltà di Medicina e Chirurgia, Università "G. d'Annunzio" di Chieti-Pescara, Italy. tiboni@unich.it
authors.forename: Gian Mario
authors.initials: GM
authors.lastname: Tiboni
authors.forename: Francesca
authors.initials: F
authors.lastname: Marotta
authors.forename: Anna Pia
authors.initials: AP
authors.lastname: Castigliego
mesh_terms: D000014:Abnormalities, Drug-Induced; D000818:Animals; D000890:Anti-Infective Agents / Q000633:toxicity*; D001842:Bone and Bones / Q000002:abnormalities; D004357:Drug Synergism; D005260:Female; D008795:Metronidazole / Q000633:toxicity*; D051379:Mice; D008813:Mice, Inbred ICR; D008825:Miconazole / Q000633:toxicity*; D011247:Pregnancy
chemical_list: D000890:Anti-Infective Agents; D008795:Metronidazole; D008825:Miconazole