title: Genotoxic effect of 2,4,6-trichlorophenol on p53 gene in zebrafish liver.
abstract: Trichlorophenol (2,4,6-trichlorophenol [TCP]), a probable human carcinogen, is widely present in the environment. Employing denaturing high-performance liquid chromatography and DNA sequencing analyses, we demonstrated that 10-d exposure of zebrafish to TCP at 5 microg/L resulted in elevated point mutations of p53 gene in the liver genome. The result suggests that TCP might be involved in carcinogenesis by inducing point mutations in the somatic genome.
authors.affiliation: School of Environment, State Key Laboratory of Pollution Control and Resource Reuse, Nanjing University, Nanjing, China.
authors.forename: Daqiang
authors.initials: D
authors.lastname: Yin
authors.forename: Hankai
authors.initials: H
authors.lastname: Zhu
authors.forename: Ping
authors.initials: P
authors.lastname: Hu
authors.forename: Qingshun
authors.initials: Q
authors.lastname: Zhao
mesh_terms: D000818:Animals; D002733:Chlorophenols / Q000633:toxicity*; D008099:Liver / Q000187:drug effects*; D009153:Mutagens; D017354:Point Mutation / Q000187:drug effects; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*; D015027:Zebrafish
chemical_list: D002733:Chlorophenols; D009153:Mutagens; D016159:Tumor Suppressor Protein p53; C024564:2,4,6-trichlorophenol