CMV and the art of memory maintenance.
The CD8(+) T cell responses to CMV gradually increase in magnitude over time-so-called memory "inflation." In this issue of Immunity, Snyder et al. (2008) examine the dynamics of memory inflation and demonstrate continuous turnover of inflating T cells, drawing on both memory cells and naive cells to replace them.
Klenerman
Paul
P
Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK. paul.klenerman@ndm.ox.ac.uk
Dunbar
P Rod
PR
D000818:Animals; D015703:Antigens, CD / Q000276:immunology / Q000378:metabolism*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D016207:Cytokines / Q000276:immunology / Q000378:metabolism*; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000276:immunology* / Q000821:virology; D006566:Herpesviridae Infections / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory; D051379:Mice; D018146:Muromegalovirus / Q000276:immunology*
D015703:Antigens, CD; D016207:Cytokines