title: In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria.
abstract: The antianaerobic activity of tomopenem, a new longer-half-life parenteral carbapenem, was compared with other carbapenems. Tomopenem showed broad activity against 63 reference species. The activity of tomopenem against 293 clinical isolates was potent (MIC(90), 0.06 to 4 microg/ml) and comparable to those of meropenem and doripenem and more potent than that of panipenem.
authors.affiliation: Division of Anaerobe Research, Life Science Research Center, Gifu University, Gifu, Japan. kktb@gifu-u.ac.jp
authors.forename: Kaori
authors.initials: K
authors.lastname: Tanaka
authors.forename: Hiroshige
authors.initials: H
authors.lastname: Mikamo
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nakao
authors.forename: Taku
authors.initials: T
authors.lastname: Ichiishi
authors.forename: Takatsugu
authors.initials: T
authors.lastname: Goto
authors.forename: Yuka
authors.initials: Y
authors.lastname: Yamagishi
authors.forename: Kunitomo
authors.initials: K
authors.lastname: Watanabe
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D015780:Carbapenems / Q000494:pharmacology*; D000077726:Doripenem; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D013845:Thienamycins / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D013845:Thienamycins; D000077726:Doripenem; D000077731:Meropenem; C039536:panipenem