title: Understanding haemophilic arthropathy: an exploration of current open issues.
abstract: Haemophilic arthropathy is joint damage evolving from recurrent joint bleeds that occur in patients suffering from the clotting disorder haemophilia. Insight into the pathogenetic mechanism of this blood-induced arthropathy yields possible treatment targets and modalities useful to reduce this invalidating co-morbidity of haemophilia. Joint bleeding leads to initially independent adverse changes in both the synovial tissue and the articular cartilage. These subsequently influence each other: the synovial inflammatory changes enhancing cartilage damage and vice versa. Consequently, effective treatment strategies will have to affect both pathways.
authors.affiliation: Rheumatology & Clinical Immunology, University Medical Center (UMC) Utrecht, Utrecht, The Netherlands. n.w.d.jansen@umcutrecht.nl
authors.forename: Nathalie W D
authors.initials: NW
authors.lastname: Jansen
authors.forename: Goris
authors.initials: G
authors.lastname: Roosendaal
authors.forename: Floris P J G
authors.initials: FP
authors.lastname: Lafeber
mesh_terms: D001779:Blood Coagulation Factors / Q000627:therapeutic use; D002358:Cartilage, Articular / Q000473:pathology; D006395:Hemarthrosis / Q000473:pathology* / Q000628:therapy; D006467:Hemophilia A / Q000473:pathology / Q000628:therapy; D006801:Humans; D007596:Joints / Q000473:pathology*; D013583:Synovial Membrane / Q000473:pathology
chemical_list: D001779:Blood Coagulation Factors