title: Visualization of cerebrospinal fluid movement with spin labeling at MR imaging: preliminary results in normal and pathophysiologic conditions.
abstract: Institutional review board approval and informed consent were obtained for this study. This study was HIPAA compliant. The purpose of this study was to visualize the movement of cerebrospinal fluid (CSF) noninvasively by using an unenhanced magnetic resonance imaging technique. A time-spatial labeling inversion pulse (SLIP) technique was applied to label, or tag, CSF in a region of interest. The tagged CSF was clearly visualized at inversion times of 1500-4500 msec after pulse labeling in both intracranial and intraspinal compartments. Noninvasive visualization of CSF movement, including bulk and turbulent flow, in normal (n = 7) and altered (n = 2) physiologic conditions was possible by using the unenhanced time-SLIP technique.
authors.affiliation: Department of Neurosurgery, Tokai University at Oiso Hospital, Kanagawa, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Yamada
authors.forename: Mitsue
authors.initials: M
authors.lastname: Miyazaki
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kanazawa
authors.forename: Minako
authors.initials: M
authors.lastname: Higashi
authors.forename: Yukuo
authors.initials: Y
authors.lastname: Morohoshi
authors.forename: Stefan
authors.initials: S
authors.lastname: Bluml
authors.forename: J Gordon
authors.initials: JG
authors.lastname: McComb
mesh_terms: D000328:Adult; D016080:Arachnoid Cysts / Q000503:physiopathology*; D002555:Cerebrospinal Fluid / Q000502:physiology*; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D019047:Phantoms, Imaging; D013113:Spin Labels
chemical_list: D013113:Spin Labels