Genomic-scale prioritization of drug targets: the TDR Targets database.
The increasing availability of genomic data for pathogens that cause tropical diseases has created new opportunities for drug discovery and development. However, if the potential of such data is to be fully exploited, the data must be effectively integrated and be easy to interrogate. Here, we discuss the development of the TDR Targets database (http://tdrtargets.org), which encompasses extensive genetic, biochemical and pharmacological data related to tropical disease pathogens, as well as computationally predicted druggability for potential targets and compound desirability information. By allowing the integration and weighting of this information, this database aims to facilitate the identification and prioritization of candidate drug targets for pathogens.
Agüero
Fernán
F
Instituto de Investigaciones Biotecnológicas, Universidad Nacional de General San Martín, San Martín 1650, Buenos Aires, Argentina. fernan@unsam.edu.ar
Al-Lazikani
Bissan
B
Aslett
Martin
M
Berriman
Matthew
M
Buckner
Frederick S
FS
Campbell
Robert K
RK
Carmona
Santiago
S
Carruthers
Ian M
IM
Chan
A W Edith
AW
Chen
Feng
F
Crowther
Gregory J
GJ
Doyle
Maria A
MA
Hertz-Fowler
Christiane
C
Hopkins
Andrew L
AL
McAllister
Gregg
G
Nwaka
Solomon
S
Overington
John P
JP
Pain
Arnab
A
Paolini
Gaia V
GV
Pieper
Ursula
U
Ralph
Stuart A
SA
Riechers
Aaron
A
Roos
David S
DS
Sali
Andrej
A
Shanmugam
Dhanasekaran
D
Suzuki
Takashi
T
Van Voorhis
Wesley C
WC
Verlinde
Christophe L M J
CL
D000818:Animals; D003141:Communicable Diseases / Q000188:drug therapy / Q000382:microbiology / Q000469:parasitology / Q000821:virology; D030541:Databases, Genetic; D015195:Drug Design; D016678:Genome; D006801:Humans