title: Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder.
abstract: A time-to-onset analysis for family-based samples was performed on the genomewide association (GWAS) data for attention deficit hyperactivity disorder (ADHD) to determine if associations exist with the age at onset of ADHD. The initial dataset consisted of 958 parent-offspring trios that were genotyped on the Perlegen 600,000 SNP array. After data cleaning procedures, 429,981 autosomal SNPs and 930 parent-offspring trios were used found suitable for use and a family-based logrank analysis was performed using that age at first ADHD symptoms as the quantitative trait of interest. No SNP achieved genome-wide significance, and the lowest P-values had a magnitude of 10(-7). Several SNPs among a pre-specified list of candidate genes had nominal associations including SLC9A9, DRD1, ADRB2, SLC6A3, NFIL3, ADRB1, SYT1, HTR2A, ARRB2, and CHRNA4. Of these findings SLC9A9 stood out as a promising candidate, with nominally significant SNPs in six distinct regions of the gene.
authors.affiliation: Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Jessica
authors.initials: J
authors.lastname: Lasky-Su
authors.forename: Richard J L
authors.initials: RJ
authors.lastname: Anney
authors.forename: Benjamin M
authors.initials: BM
authors.lastname: Neale
authors.forename: Barbara
authors.initials: B
authors.lastname: Franke
authors.forename: Kaixin
authors.initials: K
authors.lastname: Zhou
authors.forename: Julian B
authors.initials: JB
authors.lastname: Maller
authors.forename: Alejandro Arias
authors.initials: AA
authors.lastname: Vasquez
authors.forename: Wai
authors.initials: W
authors.lastname: Chen
authors.forename: Philip
authors.initials: P
authors.lastname: Asherson
authors.forename: Jan
authors.initials: J
authors.lastname: Buitelaar
authors.forename: Tobias
authors.initials: T
authors.lastname: Banaschewski
authors.forename: Richard
authors.initials: R
authors.lastname: Ebstein
authors.forename: Michael
authors.initials: M
authors.lastname: Gill
authors.forename: Ana
authors.initials: A
authors.lastname: Miranda
authors.forename: Fernando
authors.initials: F
authors.lastname: Mulas
authors.forename: Robert D
authors.initials: RD
authors.lastname: Oades
authors.forename: Herbert
authors.initials: H
authors.lastname: Roeyers
authors.forename: Aribert
authors.initials: A
authors.lastname: Rothenberger
authors.forename: Joseph
authors.initials: J
authors.lastname: Sergeant
authors.forename: Edmund
authors.initials: E
authors.lastname: Sonuga-Barke
authors.forename: Hans Christoph
authors.initials: HC
authors.lastname: Steinhausen
authors.forename: Eric
authors.initials: E
authors.lastname: Taylor
authors.forename: Mark
authors.initials: M
authors.lastname: Daly
authors.forename: Nan
authors.initials: N
authors.lastname: Laird
authors.forename: Christoph
authors.initials: C
authors.lastname: Lange
authors.forename: Stephen V
authors.initials: SV
authors.lastname: Faraone
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D055106:Genome-Wide Association Study; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide; D011336:Probability; D040641:Quantitative Trait Loci; D012189:Retrospective Studies; D017923:Sodium-Hydrogen Exchangers / Q000235:genetics
chemical_list: D005819:Genetic Markers; C478541:SLC9A9 protein, human; D017923:Sodium-Hydrogen Exchangers