Synthesis of biindolyls via palladium-catalyzed reactions.
An unprecedented synthesis of a range of high value homo- and heterobiindolyls is presented. The one-pot Miyaura borylation and subsequent Suzuki-Miyaura coupling sequence allows for the construction of the highly sterically congested C-C bond between two bromoindoles in modest to good overall yields.
Duong
Hung A
HA
Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research, 1 Pesek Rd, Jurong Island, Singapore 627833.
Chua
Sheena
S
Huleatt
Paul B
PB
Chai
Christina L L
CL
D001897:Boronic Acids / Q000737:chemistry; D002384:Catalysis; D007202:Indicators and Reagents / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D008024:Ligands; D010165:Palladium / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry
D001897:Boronic Acids; D007202:Indicators and Reagents; D007211:Indoles; D008024:Ligands; D012997:Solvents; D010165:Palladium