Synthesis, conformational analysis and biological studies of cyclic cationic antimicrobial peptides containing sugar amino acids.
Sugar amino acid based 24-membered macrocyclic C2-symmetric cationic peptides were designed and synthesized. The cationic group was introduced in the sugar amino acids. The conformation of these cyclic compounds was ascertained through NMR techniques, which proved they were amphipathic in nature. All the compounds were bacteriolytic, showed good activity against the Gr(+ve) and Gr(-ve) bacteria, and exhibited low hemolytic activity.
Chakraborty
Tushar Kanti
TK
Indian Institute of Chemical Technology and Centre for Cellular and Molecular Biology, Hyderabad 500607, India. chakraborty@iict.res.in
Koley
Dipankar
D
Ravi
Rapolu
R
Krishnakumari
Viswanatha
V
Nagaraj
Ramakrishnan
R
Kunwar
Ajit Chand
AC
D000596:Amino Acids / Q000737:chemistry*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D023181:Antimicrobial Cationic Peptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002241:Carbohydrates / Q000737:chemistry*; D002942:Circular Dichroism; D004912:Erythrocytes / Q000187:drug effects / Q000473:pathology; D006461:Hemolysis / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011487:Protein Conformation; D051381:Rats; D014867:Water / Q000737:chemistry
D000596:Amino Acids; D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D002241:Carbohydrates; D010456:Peptides, Cyclic; D014867:Water