title: A scaffold makes the switch.
abstract: Protein kinase cascades are a reoccurring feature of signal transduction pathways. Recent investigations have focused on how kinase-scaffolding proteins help to convert a graded stimulus into a switch-like or binary response. New findings reveal that the graded-to-binary conversion can be turned on or off, depending on the location of the scaffold within the cell.
authors.affiliation: Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599-7260, USA. henrik_dohlman@med.unc.edu
authors.forename: Henrik G
authors.initials: HG
authors.lastname: Dohlman
mesh_terms: D000818:Animals; D006801:Humans; D020935:MAP Kinase Signaling System / Q000502:physiology*; D020929:Mitogen-Activated Protein Kinase Kinases / Q000378:metabolism*; D008954:Models, Biological; D011494:Protein Kinases / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000502:physiology
chemical_list: D011494:Protein Kinases; D020929:Mitogen-Activated Protein Kinase Kinases