[Treatment of severe digoxin intoxication with antidote].
In the case of severe digoxin intoxication, an antidote digoxin immune Fab (Digibind) is available. Digibind binds and inactivates digoxin. Measuring se-digoxin after administering Digibind (by standard measuring methods) is misleading as Digibind interferes with digitalis immunoassay measurements. The effect of Digibind must be estimated on the basis of the disappearance of the patient's symptoms and cardiac abnormalities. A case involving Fab therapy of a digoxin-overdosed patient is reported.
Houlberg
Eva
E
Elstedvej 55, DK-2610 Rødovre. eva@thinknew.dk
Blicher
Thalia M Estrup
TM
D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000097:blood / Q000506:poisoning*; D017544:Aortic Aneurysm, Abdominal / Q000601:surgery; D004077:Digoxin / Q000008:administration & dosage / Q000097:blood / Q000506:poisoning*; D062787:Drug Overdose; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000627:therapeutic use*; D008297:Male; D011183:Postoperative Complications / Q000209:etiology / Q000378:metabolism; D051437:Renal Insufficiency / Q000209:etiology / Q000378:metabolism
D000889:Anti-Arrhythmia Agents; D007140:Immunoglobulin Fab Fragments; C050199:digoxin antibodies Fab fragments; D004077:Digoxin