title: A clinical phenotype of distal hereditary motor neuronopathy type II with a novel HSPB1 mutation.
abstract: We report a Japanese family with distal hereditary motor neuronopathy type II (distal HMN II) due to a novel K141Q mutation in heat-shock 27-kDa protein 1 gene (HSPB1/HSP27). A 47-year-old man (proband) with diabetes mellitus (DM) developed distal wasting and weakness of the legs and severe autonomic dysfunctions in his early forties, while his father and grandfather, without DM, demonstrated slowly progressive muscular wasting and weakness in all limbs still later in life. This mutation appears linked with the late-onset clinical phenotype as distal HMN II. Severe autonomic disturbances in the proband were probably due to uncontrolled DM, but may have been related to HSPB1 mutation.
authors.affiliation: Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan. yoshi-i@med.kanazawa-u.ac.jp
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Akiko
authors.initials: A
authors.lastname: Abe
authors.forename: Chiho
authors.initials: C
authors.lastname: Ishida
authors.forename: Kazuya
authors.initials: K
authors.lastname: Takahashi
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Hayasaka
authors.forename: Masahito
authors.initials: M
authors.lastname: Yamada
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D002607:Charcot-Marie-Tooth Disease / Q000208:ethnology / Q000235:genetics*; D005192:Family Health; D055551:HSP27 Heat-Shock Proteins / Q000737:chemistry / Q000235:genetics*; D006360:Heat-Shock Proteins; D006801:Humans; D008297:Male; D008875:Middle Aged; D018832:Molecular Chaperones; D010375:Pedigree; D010641:Phenotype; D017354:Point Mutation; D017433:Protein Structure, Secondary
chemical_list: D055551:HSP27 Heat-Shock Proteins; C057725:HSPB1 protein, human; D006360:Heat-Shock Proteins; D018832:Molecular Chaperones