title: Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis.
abstract: The screening of a diversity-oriented synthesis library followed by structure-activity relationship investigations have led to the discovery of an anti-MRSA agent which operates as an inhibitor of Staphylococcus aureus dihydrofolate reductase.
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK.
authors.forename: Emma E
authors.initials: EE
authors.lastname: Wyatt
authors.forename: Warren R J D
authors.initials: WR
authors.lastname: Galloway
authors.forename: Gemma L
authors.initials: GL
authors.lastname: Thomas
authors.forename: Martin
authors.initials: M
authors.lastname: Welch
authors.forename: Olivier
authors.initials: O
authors.lastname: Loiseleur
authors.forename: Alleyn T
authors.initials: AT
authors.lastname: Plowright
authors.forename: David R
authors.initials: DR
authors.lastname: Spring
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005493:Folic Acid Antagonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000201:enzymology*; D013329:Structure-Activity Relationship; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D005493:Folic Acid Antagonists; D013762:Tetrahydrofolate Dehydrogenase