title: Russell body apical periodontitis: an unusual case report.
abstract: Russell bodies (RBs) changes in chronic apical lesions have rarely been reported in the literature. We describe a case of a periapical lesion abundantly and extensively composed of RB. Microscopic examination showed accumulation of plasma cells containing globular, spherical, polygonal, and eosinophilic structures against fibrous connective tissue. Initial diagnostic considerations based on a smaller magnification included hypersecretory plasmocytoma, although there was no evidence of infiltrative growth, mitotic activity, nuclear atypia, or cellular pleomorphism. Then, a panel of immunohistochemical markers was applied and the cells showed positivity with both kappa and lambda chains demonstrating their polyclonal origin. The extensive accumulation of RBs involving the periapical region represents an unreported and significant histologic change, as it was mimicking a malignant neoplasm.
authors.affiliation: Laboratory of Oral Surgical Pathology, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil. jeanunes@ufba.br
authors.forename: Jean Nunes
authors.initials: JN
authors.lastname: Dos Santos
authors.forename: Eduardo Antônio Gonçalves
authors.initials: EA
authors.lastname: Ramos
authors.forename: Clarissa Araújo Silva
authors.initials: CA
authors.lastname: Gurgel
authors.forename: Adna Conceição
authors.initials: AC
authors.lastname: Barros
authors.forename: André Carlos
authors.initials: AC
authors.lastname: de Freitas
authors.forename: Iêda Maria
authors.initials: IM
authors.lastname: Crusoé-Rebello
mesh_terms: D000328:Adult; D002908:Chronic Disease; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D002479:Inclusion Bodies / Q000473:pathology*; D007573:Jaw Neoplasms / Q000175:diagnosis; D010485:Periapical Periodontitis / Q000473:pathology*; D010950:Plasma Cells / Q000473:pathology