Fracturing rings to understand lantibiotics.
Haloduracin is a bacterially produced antibiotic system of two alkali-stable peptides (Halalpha and Halbeta) that have extensive posttranslational modifications, including lanthionine rings. Now, Cooper et al. (2008) revise the structure of Halbeta and demonstrate that some of the lanthionine rings are not essential for bioactivity.
Yoganathan
Sabesan
S
Department of Chemistry, University of Alberta, Edmonton, AB T6G 2G2, Canada.
Vederas
John C
JC
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000737:chemistry; D001407:Bacillus / Q000737:chemistry / Q000378:metabolism; D001430:Bacteriocins / Q000096:biosynthesis / Q000737:chemistry* / Q000378:metabolism; D006801:Humans
D000900:Anti-Bacterial Agents; D001430:Bacteriocins; C515824:haloduracin, Bacillus halodurans