title: Posaconazole mono- or combination therapy for treatment of murine zygomycosis.
abstract: We compared the efficacy of combination posaconazole-liposomal amphotericin B (LAmB) therapy to monotherapy with either drug in diabetic ketoacidotic or neutropenic mice with disseminated zygomycosis caused by Rhizopus oryzae. Combination therapy was no better than LAmB alone, and posaconazole monotherapy did not improve survival or reduce fungal burden versus placebo.
authors.affiliation: Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles Medical Center, Torrance, 90502, USA. ibrahim@labiomed.org
authors.forename: Ashraf S
authors.initials: AS
authors.lastname: Ibrahim
authors.forename: Teclegiorgis
authors.initials: T
authors.lastname: Gebremariam
authors.forename: Julie A
authors.initials: JA
authors.lastname: Schwartz
authors.forename: John E
authors.initials: JE
authors.lastname: Edwards
authors.forename: Brad
authors.initials: B
authors.lastname: Spellberg
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001921:Brain / Q000382:microbiology / Q000473:pathology; D016883:Diabetic Ketoacidosis / Q000150:complications; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D007668:Kidney / Q000382:microbiology / Q000473:pathology; D008081:Liposomes; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009503:Neutropenia / Q000150:complications; D012233:Rhizopus; D014230:Triazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D020096:Zygomycosis / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D004338:Drug Combinations; D008081:Liposomes; D014230:Triazoles; C101425:posaconazole; D000666:Amphotericin B