Predictors of remission and recovery in a first-episode schizophrenia spectrum disorder sample: 2-year follow-up of the OPUS trial.
OBJECTIVE
To examine the frequency and predictors of good outcome for patients with first-episode schizophrenia spectrum disorder (SSD).


METHODS
We conducted a 2-year follow-up of a cohort of patients (n = 547) with first-episode SSD. We evaluated the patients on demographic variables, diagnosis, duration of untreated psychosis (DUP), premorbid functioning, psychotic and negative symptoms, substance abuse, adherence to medication, and service use. ORs were calculated with logistic regression analyses.


RESULTS
A total of 369 patients (67%) participated in the follow-up interview. After 2 years, 36% remitted and 17% were considered fully recovered. Full recovery was associated with shorter DUP, better premorbid adjustment, fewer negative symptoms at baseline, no substance abuse at baseline, and adherence to medication and OPUS treatment.


CONCLUSIONS
Several predictive factors were identified, and focus should be on potentially malleable predictors of outcome, for example, reducing DUP and paying special attention to patients who are unlikely to achieve good outcome, for example, patients with a substance abuse problem and poor premorbid adjustment.
Petersen
Lone
L
Bispebjerg Hospital, Department of Psychiatry, Copenhagen NV, Denmark. lonepetersen@mail.dk
Thorup
Anne
A
Øqhlenschlaeger
Johan
J
Christensen
Torben Øqstergaard
TØ
Jeppesen
Pia
P
Krarup
Gertrud
G
Jørrgensen
Per
P
Mortensen
Erik Lykke
EL
Nordentoft
Merete
M
D000328:Adult; D015331:Cohort Studies; D003131:Combined Modality Therapy; D003156:Community Mental Health Services; D015897:Comorbidity; D003718:Denmark; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010349:Patient Compliance / Q000523:psychology; D011613:Psychotherapy / Q000379:methods; D011619:Psychotropic Drugs / Q000627:therapeutic use; D012559:Schizophrenia / Q000453:epidemiology / Q000534:rehabilitation*; D012565:Schizophrenic Psychology; D019966:Substance-Related Disorders / Q000453:epidemiology / Q000523:psychology / Q000534:rehabilitation; D055815:Young Adult
D011619:Psychotropic Drugs