Nanoengineering ion channels for optical control.
Chemical modification with photoisomerizable tethered ligands endows proteins with sensitivity to light. These optically actuated proteins are revolutionizing research in biology by making it possible to manipulate biological processes noninvasively and with unprecedented spatiotemporal resolution.
Gorostiza
Pau
P
Institut de Bioenginyeria de Catalunya (IBEC), Institució Catalana de Recerca i Estudis Avançats (ICREA), and CIBER-BBN, Parc Científic de Barcelona, Barcelona, Spain.
Isacoff
Ehud Y
EY
D000818:Animals; D001391:Azo Compounds / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D015640:Ion Channel Gating / Q000187:drug effects / Q000528:radiation effects; D007473:Ion Channels / Q000502:physiology* / Q000528:radiation effects*; D008024:Ligands; D008027:Light; D055537:Light Signal Transduction / Q000187:drug effects / Q000502:physiology*; D036103:Nanotechnology / Q000639:trends*
D001391:Azo Compounds; D007473:Ion Channels; D008024:Ligands; C009850:azobenzene