title: [Expression and clinical significance of cyclin H and CDK7 in human hemangiomas].
abstract: OBJECTIVE
  To investigate the expression and clinical significance of cyclin H and cyclin-dependent kinase 7 (CDK7) in human hemangiomas.
  
  
  METHODS
  Immunohistochemistry technique was used to measure the expression of cyclin H and CDK7 proteins in proliferative, involuting hemangiomas and normal skin tissues. Immunohistochemical technique for factor VIII-related antigen was used to prove that the cells which expressed cyclin H and CDK7 were endothelial cells. Average optical density and positive area of the expression of cyclin H and CDK7 proteins in proliferative, involuting hemangiomas and normal skin tissues were measured by image analysis (HPIAS-1000).
  
  
  RESULTS
  The expression of cyclin H and CDK7 protein in proliferating hemangiomas was significantly higher than that in involuting hemangiomas and normal skin tissues (P < 0.01). But no significant difference was found in the expression of cyclin H and CDK7 protein between involuting hemangiomas and normal skin tissues (P > 0.05).
  
  
  CONCLUSIONS
  cyclin H and CDK7 may play an important role in the generation and development of human hemangiomas.
authors.affiliation: Department of Geriatrics, Renmin Hospital of Wuhan University, Wuhan 430060, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Liu
authors.forename: Duan-Lian
authors.initials: DL
authors.lastname: Zhang
authors.forename: Sheng-Guo
authors.initials: SG
authors.lastname: Shan
mesh_terms: D056748:Cyclin H / Q000378:metabolism*; D018844:Cyclin-Dependent Kinases / Q000378:metabolism*; D006391:Hemangioma / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D012878:Skin Neoplasms / Q000378:metabolism*; D000095043:Cyclin-Dependent Kinase-Activating Kinase
chemical_list: D056748:Cyclin H; D018844:Cyclin-Dependent Kinases; D000095043:Cyclin-Dependent Kinase-Activating Kinase; C000722416:CDK7 protein, human