title: Macelignan attenuates LPS-induced inflammation and reduces LPS-induced spatial learning impairments in rats.
abstract: Previous studies have shown that macelignan has anti-inflammatory and neuroprotective effects. Subsequently, in the current study, we demonstrate that oral administrations of macelignan reduce the hippocampal microglial activation induced by chronic infusions of lipopolysaccharide (LPS) into the fourth ventricle of Fisher-344 rat brains. A Morris water maze was used to evaluate the status of the hippocampal-dependent spatial learning in control rats with an artificial cerebrospinal fluid infusion, rats with chronic LPS infusions, and rats with chronic LPS infusions and oral administrations of macelignan. The rats with chronic LPS infusions showed spatial memory impairments relative to the control rats in the performance of the memory task. Daily administration of macelignan reduced the spatial memory impairments induced by the chronic LPS infusions. The results indicate that macelignan may possess therapeutic potential for the prevention of Alzheimer's disease.
authors.affiliation: Department of Anatomy, Yanbian University School of Basic Medical Science, Yanbian 133-000, China.
authors.forename: Chun-Ai
authors.initials: CA
authors.lastname: Cui
authors.forename: Da-Qing
authors.initials: DQ
authors.lastname: Jin
authors.forename: Yoo Kyeong
authors.initials: YK
authors.lastname: Hwang
authors.forename: Im-Soon
authors.initials: IS
authors.lastname: Lee
authors.forename: Jae Kwan
authors.initials: JK
authors.lastname: Hwang
authors.forename: Ilho
authors.initials: I
authors.lastname: Ha
authors.forename: Jung-Soo
authors.initials: JS
authors.lastname: Han
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D000949:Histocompatibility Antigens Class II / Q000378:metabolism; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D007859:Learning Disabilities / Q000139:chemically induced / Q000188:drug therapy*; D017705:Lignans / Q000627:therapeutic use*; D008070:Lipopolysaccharides; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D017628:Microglia / Q000187:drug effects; D051381:Rats; D011916:Rats, Inbred F344; D011930:Reaction Time / Q000187:drug effects; D013028:Space Perception / Q000187:drug effects*
chemical_list: D000949:Histocompatibility Antigens Class II; D017705:Lignans; D008070:Lipopolysaccharides; C502026:macelignan