title: Association of mitochondrial haplogroup J and mtDNA oxidative damage in two different North Spain elderly populations.
abstract: This work investigates the association between longevity, mitochondrial DNA (mtDNA) variants and oxidative DNA damage in an older than 85 years population. The participants, similar in genetic and cultural background as well as gender distribution, come from villages near to the Pyrenees Mountains (900-1,400 m altitude) (n = 69) and the Ebro's Valley (200-300 m altitude) (n = 69) in Spain. Our results show an accumulation of the haplogroup J in elderly individuals with an over-representation of J2 in Pyrenees group but not in the Ebro's Valley, the former associating with a diminished DNA damage. In conclusion, our results suggest that J mitochondrial variant, that induce lower mtDNA damage, could present a phenotypic survival advantage to environmental conditions and, thus, accumulate in elderly population.
authors.affiliation: Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, Zaragoza, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Domínguez-Garrido
authors.forename: Diana
authors.initials: D
authors.lastname: Martínez-Redondo
authors.forename: Carmen
authors.initials: C
authors.lastname: Martín-Ruiz
authors.forename: Aurora
authors.initials: A
authors.lastname: Gómez-Durán
authors.forename: Eduardo
authors.initials: E
authors.lastname: Ruiz-Pesini
authors.forename: Pilar
authors.initials: P
authors.lastname: Madero
authors.forename: Manuel
authors.initials: M
authors.lastname: Tamparillas
authors.forename: Julio
authors.initials: J
authors.lastname: Montoya
authors.forename: Thomas
authors.initials: T
authors.lastname: von Zglinicki
authors.forename: Carmen
authors.initials: C
authors.lastname: Díez-Sánchez
authors.forename: Manuel J
authors.initials: MJ
authors.lastname: López-Pérez
mesh_terms: D000064:Acclimatization / Q000235:genetics; D000328:Adult; D000367:Age Factors; D000369:Aged, 80 and over; D000531:Altitude; D016022:Case-Control Studies; D004249:DNA Damage; D004272:DNA, Mitochondrial / Q000378:metabolism*; D005260:Female; D006239:Haplotypes; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008297:Male; D018384:Oxidative Stress / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic; D013030:Spain; D055815:Young Adult
chemical_list: D004272:DNA, Mitochondrial