Relationship of apoE polymorphism with lipoprotein(a), apoA, apoB and lipid levels in atherosclerotic infarct.
OBJECTIVE
Apolipoprotein E (apoE) polymorphism is suggested to be a risk factor in stroke in some populations, either by affecting lipid parameters or independently. Its effect on lipoprotein(a) [Lp(a)] is not known. The roles of apoE polymorphism and of high Lp(a) levels in atherosclerotic stroke (AS) in the Turkish population are unclear. Our aim was to investigate the relationship of apoE alleles and Lp(a) level with AS and the relationship of apoE alleles with Lp(a) and other lipid parameters.


METHODS
ApoE polymorphisms and lipid parameters were prospectively evaluated in 85 patients and 77 controls with normal brain imaging.


RESULTS
Only hypertension, diabetes mellitus, associated vascular diseases and decreased high-density lipoprotein cholesterol levels were found to be independent risk factors for stroke. However, in the presence of apoE/E4 allele, increased low-density lipoprotein cholesterol (LDL-chol), apolipoprotein B (apoB) and Lp(a) levels and in the presence of apo E/E3 allele, only Lp(a) levels were determined as risk factors.


CONCLUSIONS
This study showed that while apoE polymorphism was not a risk factor itself, high Lp(a), LDL-chol and apoB were determined to be risk factors in E3 or E4 carriers.
Tascilar
N
N
Department of Neurology, Zonguldak Karaelmas University Medical Faculty, Zonguldak, Turkey. doga24@yahoo.com
Dursun
A
A
Ankarali
H
H
Mungan
G
G
Sumbuloglu
V
V
Ekem
S
S
Bozdogan
S
S
Baris
S
S
Aciman
E
E
Cabuk
F
F
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D053318:Apolipoprotein E3 / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics*; D001054:Apolipoproteins A / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D050197:Atherosclerosis / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D002544:Cerebral Infarction / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism
D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001054:Apolipoproteins A; D001055:Apolipoproteins B; D008078:Cholesterol, LDL; D017270:Lipoprotein(a); D008074:Lipoproteins