title: [Long-term safety of therapeutic botulinum toxin A].
abstract: For more than 20 years, therapeutic botulinum toxin A has been applied with success. With this long experience, the substance can viewed as safe and low in side effects. This was confirmed by a recent meta-analysis of placebo-controlled clinical studies. The side effects documented were light to moderate, temporary, and local. In respect to the frequently needed long-term therapy, it is necessary that botulinum toxin A be safe and cause no disturbance. The development of neutralizing antibodies to botulinum toxin A is very rare and no longer has an appreciable effect on its clinical application.
authors.affiliation: Neurologische Klinik mit klinischer Neurophysiologie, Klinikum Augsburg. markus.naumann@klinikum-augsburg.de
authors.forename: M
authors.initials: M
authors.lastname: Naumann
mesh_terms: D019274:Botulinum Toxins, Type A / Q000009:adverse effects* / Q000627:therapeutic use*; D002986:Clinical Trials as Topic / Q000639:trends*; D006801:Humans; D008137:Longitudinal Studies; D009468:Neuromuscular Diseases / Q000139:chemically induced* / Q000188:drug therapy*; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D019274:Botulinum Toxins, Type A