Nifedipine regulated periodontal ligament remodeling: an experimental study in rats.
OBJECTIVE
The aim of this study was to investigate the effects of nifedipine on periodontal ligament remodeling during orthodontic tooth movement.


METHODS
Sixty male Sprague-Dawley rats were randomly divided into an orthodontic group and groups that received either 10 mg/kg or 40 mg/kg nifedipine (NIF). Immunohistochemical staining and image analysis were used to investigate the expression of matrix metalloproteinase (MMP)-1, -10, -13 and collagen-I in PDL, and maxillary 1st molar displacement was measured.


RESULTS
Expression of MMP-1, -10, and -13 was significantly decreased in both NIF groups, while collagen-I expression was markedly increased. NIF significantly inhibited tooth movement.


CONCLUSIONS
NIF affects the expression of MMP-1, -10, -13 and collagen-I and tooth movement induced by orthodontic force in rats, thus indicating that calcium channels might be important in mediating PDL remodeling.
Zhang
Miao-Miao
MM
Department of Orthodontics, College of Stomatology, Harbin Medical University, Harbin 150001, PR China.
Feng
Dong-Fei
DF
Shao
Ping
P
Sun
Ting-Ting
TT
Wang
Ling
L
Yang
Bao-Feng
BF
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D024042:Collagen Type I / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D008297:Male; D020782:Matrix Metalloproteinases / Q000187:drug effects* / Q000378:metabolism; D009543:Nifedipine / Q000494:pharmacology*; D009967:Orthodontic Appliances; D010513:Periodontal Ligament / Q000187:drug effects* / Q000201:enzymology; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014087:Tooth Movement Techniques
D002121:Calcium Channel Blockers; D024042:Collagen Type I; D020782:Matrix Metalloproteinases; D009543:Nifedipine