title: An animal model of chemotherapy-induced vagal neuropathy.
abstract: In this study we establish an animal model of chemotherapy-induced autonomic neuropathy. Rats were injected with vincristine (30 and 100 microg/kg/day) for 2 weeks while cardiovascular parameters were collected telemetrically. Vincristine caused a dose-dependent decrease in vagal activity expressed by decreased parasympathetic parameters of heart rate variability, without expression of damage to the cardiac sympathetic innervation. This model can serve in assessing the potential contribution of chemotherapy-induced vagal neuropathy to morbidity and mortality.
authors.affiliation: Faculty of Social Welfare and Health Sciences, University of Haifa, Israel.
authors.forename: Irit
authors.initials: I
authors.lastname: Weissman-Fogel
authors.forename: Arkadi
authors.initials: A
authors.lastname: Dashkovsky
authors.forename: Zeev
authors.initials: Z
authors.lastname: Rogowski
authors.forename: David
authors.initials: D
authors.lastname: Yarnitsky
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects; D001342:Autonomic Nervous System Diseases / Q000139:chemically induced / Q000503:physiopathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006439:Hemodynamics / Q000502:physiology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D020421:Vagus Nerve Diseases / Q000139:chemically induced* / Q000503:physiopathology; D014750:Vincristine / Q000009:adverse effects
chemical_list: D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D014750:Vincristine