Efficient synthesis and biological evaluation of two modafinil analogues.
Non classical bioisosters of modafinil featuring interesting biological profile have been easily produced through replacement of the sulfoxide function with a carbonyl group and modification of the carboxylic acid amide functionality.
De Risi
Carmela
C
Dipartimento di Scienze Farmaceutiche, Via Fossato di Mortara 19, 44100 Ferrara, Italy. drc@unife.it
Ferraro
Luca
L
Pollini
Gian P
GP
Tanganelli
Sergio
S
Valente
Filippo
F
Veronese
Augusto C
AC
D000818:Animals; D001559:Benzhydryl Compounds / Q000737:chemistry* / Q000378:metabolism; D000697:Central Nervous System Stimulants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D003627:Data Interpretation, Statistical; D008297:Male; D000077408:Modafinil; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000737:chemistry / Q000378:metabolism; D013237:Stereoisomerism
D001559:Benzhydryl Compounds; D000697:Central Nervous System Stimulants; D012701:Serotonin; D000077408:Modafinil