Synthesis of new sulfonate and phosphonate derivatives for cation-independent mannose 6-phosphate receptor targeting.
The cation-independent mannose 6-phosphate receptor (CI-M6PR) is essential for the endocytosis of proteins bearing the mannose 6-phosphate (M6P) recognition marker. This study described the synthesis of M6P and M6S analogs presenting greater affinity for CI-M6PR than their natural compounds. Moreover, the finding of their lack of cytotoxicity for human cells and of their increased stability in human serum supports the high potential of these isosteric derivatives in therapies requiring CI-M6PR targeting.
Jeanjean
Audrey
A
Institut des Biomolécules Max Mousseron, UMR 5247, CNRS, Université Montpellier 2 et 1, Bâtiment de Recherche Max Mousseron, Ecole Nationale Supérieure de Chimie de Montpellier, 8 Rue de l'Ecole Normale, F-34296 Montpellier Cedex 05, France.
Gary-Bobo
Magali
M
Nirdé
Philippe
P
Leiris
Simon
S
Garcia
Marcel
M
Morère
Alain
A
D001667:Binding, Competitive; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D008247:Lysosomes / Q000201:enzymology; D008360:Mannosephosphates / Q000097:blood* / Q000737:chemistry; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D063065:Organophosphonates / Q000097:blood / Q000138:chemical synthesis* / Q000737:chemistry; D017527:Receptor, IGF Type 2 / Q000097:blood*; D018160:Receptors, Cytoplasmic and Nuclear / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013451:Sulfonic Acids / Q000097:blood / Q000138:chemical synthesis* / Q000737:chemistry
D006023:Glycoproteins; D008360:Mannosephosphates; D063065:Organophosphonates; D017527:Receptor, IGF Type 2; D018160:Receptors, Cytoplasmic and Nuclear; D013451:Sulfonic Acids; C034304:cation-dependent mannose-6-phosphate receptor; C027693:mannose-6-phosphate