title: Characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates in China.
abstract: Thirteen extensively drug-resistant tuberculosis isolates which were highly resistant to a broad spectrum of antituberculosis drugs were identified from 1,926 clinical isolates in China. They had highly diverse mycobacterial interspersed repetitive-unit-variable-number tandem-repeat patterns. Most, but not all, of the drug target genes had mutations contributing to resistance to the corresponding drug.
authors.affiliation: Department of Bacteriology and Immunology, Beijing Tuberculosis & Thoracic Tumor Research Institute, Tongzhou District, Beijing, China.
authors.forename: Zhaogang
authors.initials: Z
authors.lastname: Sun
authors.forename: Yanjie
authors.initials: Y
authors.lastname: Chao
authors.forename: Xuxia
authors.initials: X
authors.lastname: Zhang
authors.forename: Jianyuan
authors.initials: J
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Yunqing
authors.initials: Y
authors.lastname: Qiu
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.forename: Lihui
authors.initials: L
authors.lastname: Nie
authors.forename: Aizhen
authors.initials: A
authors.lastname: Guo
authors.forename: Chuanyou
authors.initials: C
authors.lastname: Li
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000494:pharmacology; D002681:China; D016172:DNA Fingerprinting; D004269:DNA, Bacterial / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial; D054908:Extensively Drug-Resistant Tuberculosis / Q000382:microbiology*; D005260:Female; D005798:Genes, Bacterial; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats / Q000235:genetics*; D020125:Mutation, Missense; D009169:Mycobacterium tuberculosis / Q000145:classification* / Q000187:drug effects / Q000302:isolation & purification*
chemical_list: D000995:Antitubercular Agents; D004269:DNA, Bacterial