Rapid enantiomeric excess and concentration determination using simple racemic metal complexes.
Racemic-metal complexes were used to determine identity, enantiomeric excess, and concentration of chiral diamines using metal-to-ligand charge transfer bands in circular dichroism spectroscopy. It takes under just 2 min per sample to determine [G]t and %R with tolerable errors (19% and 4%, respectively). The simplicity of the achiral receptors employed confers to this technique great potential for high-throughput screening.
Nieto
Sonia
S
Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, USA.
Lynch
Vincent M
VM
Anslyn
Eric V
EV
Kim
Hyunwoo
H
Chin
Jik
J
D002942:Circular Dichroism; D003959:Diamines / Q000032:analysis; D016014:Linear Models; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D013997:Time Factors
D003959:Diamines; D009942:Organometallic Compounds