Multiple inflammatory and serum amyloid A positive telangiectatic hepatic adenomas with glycogenated nuclei arising in a background of nonalcoholic steatohepatitis.
The authors describe multiple telangiectatic or inflammatory adenomas in a 53-year-old woman with steatohepatitis who presented with acute right upper quadrant abdominal pain. Magnetic resonance imaging revealed 6 lesions consistent with multiple hepatic adenomas, 2 of which showed hemorrhage. She underwent right lobectomy and nonanatomical segment 2 liver resections and seven nodules ranging in size from 1.0 to 5.0 cm were identified. All nodules contained portal-like structures and ductular reaction, features seen in focal nodular hyperplasia, as well as significant inflammation, telangiectatic sinusoids and immunoreactivity for serum amyloid A, placing them according to a recently described classification systems as telangiectatic or inflammatory adenomas. The diffuse positivity of the serum amyloid A staining results in this case suggests an important diagnostic role of this stain in smaller tissue samples, such as in core biopsy specimens.
Lim
Kiat H
KH
Department of Pathology, Singapore General Hospital, Singapore.
Ward
Stephen C
SC
Roayaie
Sasan
S
Cohen
Emil
E
Schwartz
Myron
M
Fiel
M Isabel
MI
Thung
Swan N
SN
D000236:Adenoma / Q000453:epidemiology / Q000473:pathology*; D015897:Comorbidity; D005234:Fatty Liver / Q000453:epidemiology / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000453:epidemiology / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D000685:Serum Amyloid A Protein / Q000032:analysis*; D013684:Telangiectasis / Q000473:pathology
D000685:Serum Amyloid A Protein