title: Technical feasibility of transperineal MR-guided prostate interventions in a low-field open MRI unit: canine study.
abstract: Magnetic resonance imaging (MRI) provides superior visualization of the prostate, its substructure, surrounding tissues, and, most important, focal lesions or cancer. The purpose of our canine study was to demonstrate the feasibility of a low-field (0.35 T) transperineal system that enables precise MR image guidance of prostate interventions. The canines were placed in the right lateral decubitus position. Template reconstruction, trajectory planning, contouring were based on T2-weighted FSE images. For image guidance and target confirmation, fast gradient spoiled-echo (FSPGR) sequence was used. MR compatible coaxial needles were manually inserted through the perineum to the base of the prostate. After satisfactory position was confirmed, brachytherapy catheters were placed through the coaxial needles. The mean deviation of the needle displacements was 2.9 mm with a median value of 2.7 mm. 97% of the errors were less than 4.0 mm. The needle placement accuracy was modelled by the Rayleigh distribution with a sigma value of 2.3 mm. Visual confirmation of needle placements was demonstrated on pathology tissue slices. The time needed for each step was: anaesthesia - 15 min, setup and positioning - 15 min, initial imaging - 15 min, template registration, projection - 15 min, contouring, trajectory planning, insertion of 12 needles - 60 min Based on our canine experiences our method seems to be a promising approach for performing feasible, accurate, reliable and high-quality prostate MR guidance within a reasonable time span.
authors.affiliation: Health Science Center, University of Kaposvar, Guba Sandor Street 40, Kaposvar H-7400, Hungary.
authors.forename: Ferenc
authors.initials: F
authors.lastname: Lakosi
authors.forename: Gergely
authors.initials: G
authors.lastname: Antal
authors.forename: Csaba
authors.initials: C
authors.lastname: Vandulek
authors.forename: Arpad
authors.initials: A
authors.lastname: Kovacs
authors.forename: Rita
authors.initials: R
authors.lastname: Garamvolgyi
authors.forename: Ors
authors.initials: O
authors.lastname: Petnehazy
authors.forename: Gabor
authors.initials: G
authors.lastname: Bajzik
authors.forename: Janaki
authors.initials: J
authors.lastname: Hadjiev
authors.forename: Imre
authors.initials: I
authors.lastname: Repa
authors.forename: Peter
authors.initials: P
authors.lastname: Bogner
mesh_terms: D000818:Animals; D001918:Brachytherapy / Q000379:methods*; D004285:Dogs; D053783:Magnetic Resonance Imaging, Interventional / Q000379:methods*; D008297:Male; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*