title: [Correlation of C-reactive protein with echocardiographic parameters of hypertrophic and ischemic heart disease in patients on regular hemodialyses].
abstract: BACKGROUND
  Cardiovascular diseases are the most frequent cause of morbidity and mortality in patients on hemodialysis. The reason for this is a high prevailance of risk factors for the development of cardiovascular complications with these patients. Microinflammation is one of the risk factors for the development of atherosclerosis of coronary arteries in patients on hemodialysis. The study was aimed at investigating correlation between microinflammation parameter C-reactive protein (CRP) and echocardiographic parameters of left ventricular hypertrophy and left ventricular dilatation (left ventricular mass index-LVMi, left ventricular end-diastolic volume index-EDVi) and echocardiographic parameters of ischemic heart disease and systolic function (systolic thickness of interventricular septum-StIVS, systolic thickness of left ventricular posterior wall-StPWLV, amplitude of motion of interventricular septum-AmmIVS, amplitude of motion of left ventricular posterior wall-AmmPWLV, left ventricular fractional shortening-LVFS, left ventricular ejectional fraction-LVEF).
  
  
  METHODS
  The research was conducted on 115 patients (M:F 7/:44) regularly treated by hemodialysis, average age 53.30+/-12.17 years, average length of dialysis 4.51+/-4.01 years and average Kt/Vsp index 1.17+/-0.23.
  
  
  RESULTS
  Average CRP was 7.50+/-9.34 mg/l, EDVi 100.80+/-34.62 ml/m2, StPWLV 54.17+/-14.03%, and AmmPWLV 6.09+/-1.58 mm. Statistically significant positive correlation between serum concentration CRP and EDVi (p=0.221) was found. Highly statistically important significant negative correlation was proved between the serum CRP concentration and StPWLV (p=-0.249) and AmmPWLV (p=-0.289).
  
  
  CONCLUSIONS
  Microinflammation is a possible risk factor for the development of atherosclerosis of coronary artheries in patients on hemodialysis.
authors.affiliation: Klinika za urologiju i nefrologiju, Odeljenje hemodijalize, Klinicki centar Kragujevac, Kragujevac. aca96@eunet.yu
authors.forename: Dejan
authors.initials: D
authors.lastname: Petrović
authors.forename: Radmila
authors.initials: R
authors.lastname: Obrenović
authors.forename: Mileta
authors.initials: M
authors.lastname: Poskurica
authors.forename: Biljana
authors.initials: B
authors.lastname: Stojimirović
mesh_terms: D002097:C-Reactive Protein / Q000032:analysis*; D004452:Echocardiography; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology; D007249:Inflammation; D018836:Inflammation Mediators / Q000097:blood; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000150:complications; D006435:Renal Dialysis; D013318:Stroke Volume; D016277:Ventricular Function, Left
chemical_list: D018836:Inflammation Mediators; D002097:C-Reactive Protein