title: Oxidative burst inhibitory and cytotoxic indoloquinazoline and furoquinoline alkaloids from Oricia suaveolens.
abstract: Two new β-indoloquinazoline alkaloids, orisuaveoline A (1) and orisuaveoline B (2), two new furoquinoline alkaloids, quinosuaveoline A (5) and quinosuaveoline B (6), and 12 known compounds were isolated from Oricia suaveolens. The structures of the new compounds were deduced by spectroscopic studies. The absolute configuration of nkolbisine (4) was also determined. Compounds 2, 3, 6-8, 10, and 14 were evaluated for oxidative burst inhibitory activity in a chemoluminescence assay and for cytotoxicity against A549 lung carcinoma cells.
authors.affiliation: Department of Chemistry, University of Douala, Faculty of Science, P.O. Box 24157 Douala, Cameroon. jdwansi@yahoo.fr
authors.forename: Jean Duplex
authors.initials: JD
authors.lastname: Wansi
authors.forename: M Ahmed
authors.initials: MA
authors.lastname: Mesaik
authors.forename: David Dako
authors.initials: DD
authors.lastname: Chiozem
authors.forename: Krishna Prasad
authors.initials: KP
authors.lastname: Devkota
authors.forename: Nicolas
authors.initials: N
authors.lastname: Gaboriaud-Kolar
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Lallemand
authors.forename: Jean
authors.initials: J
authors.lastname: Wandji
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.forename: Norbert
authors.initials: N
authors.lastname: Sewald
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D011799:Quinazolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D011804:Quinolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D016897:Respiratory Burst / Q000187:drug effects*; D027821:Rutaceae / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D005663:Furans; D007211:Indoles; D011799:Quinazolines; D011804:Quinolines; C475704:indolo(2,1-b)quinazoline; C568014:orisuaveoline A; C568015:orisuaveoline B; C568016:quinosuaveoline A; C568017:quinosuaveoline B