title: Plasmacytoid dendritic cell leukemia with potent antigen-presenting ability.
abstract: We report 2 patients with plasmacytoid dendritic cell leukemia (pDCL) expressing CD4, CD56, CD33, CD36, HLA-DR, CD123, CD86 and CD83 in the absence of lineage markers (myeloid, B, T or natural killer cells) except for CD33. Culturing leukemic blasts of both cases with IL-3 for 4 days increased the expression of surface molecules associated with antigen presentation, e.g. CD1a and CD40. Leukemic blasts of both cases possessed a considerable level of antigen-presenting ability to allogeneic lymphocytes in mixed leukocyte cultures. Culturing the blasts with IL-3 for 4 days markedly increased allogeneic antigen presenting ability. Combined with data showing evident graft-versus-leukemia effects without graft-versus-host disease in a cord blood stem cell transplanted pDCL case, leukemic cells in pDCL may act as potent antigen presenting cells in vivo, too.
authors.affiliation: Laboratory of Hematology and Oncology, Graduate School of Health Sciences, Niigata University, Niigata, Japan. naritami@clg.niigata-u.ac.jp
authors.forename: Miwako
authors.initials: M
authors.lastname: Narita
authors.forename: Takashi
authors.initials: T
authors.lastname: Kuroha
authors.forename: Norihiro
authors.initials: N
authors.lastname: Watanabe
authors.forename: Shigeo
authors.initials: S
authors.lastname: Hashimoto
authors.forename: Junjiro
authors.initials: J
authors.lastname: Tsuchiyama
authors.forename: Nozomi
authors.initials: N
authors.lastname: Tochiki
authors.forename: Anri
authors.initials: A
authors.lastname: Saitoh
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Satoh
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Furukawa
authors.forename: Ken
authors.initials: K
authors.lastname: Toba
authors.forename: Ichiro
authors.initials: I
authors.lastname: Fuse
authors.forename: Yoshifusa
authors.initials: Y
authors.lastname: Aizawa
authors.forename: Masuhiro
authors.initials: M
authors.lastname: Takahashi
mesh_terms: D000368:Aged; D017951:Antigen Presentation; D019070:Cell Lineage; D036101:Cord Blood Stem Cell Transplantation; D003713:Dendritic Cells / Q000276:immunology* / Q000473:pathology; D020544:Graft vs Leukemia Effect; D006801:Humans; D016130:Immunophenotyping; D007377:Interleukin-3 / Q000494:pharmacology; D007938:Leukemia / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D008297:Male
chemical_list: D007377:Interleukin-3