Preparation and characterization of coacervate microcapsules for the delivery of antimicrobial oyster peptides.
Oyster peptides-loaded alginate/chitosan/starch microcapsules were prepared using external gelation method and internal emulsion gelation method. The solution of oyster peptides complexes was encapsulated into the microcapsules, which endowed the microcapsules with intestine passive targeting properties. The swelling behavior, encapsulation efficiency, and release behavior of oyster peptides from the microcapsules at different pH values were investigated. The microcapsules exhibited sustained release of the peptides in intestinal medium, and the release rate could be regulated by the pH value: in simulated gastric fluid, the release rate was greatly decreased, and in simulated body fluid and intestinal fluid, the microcapsules exhibited a sustained release in 24 h with different release rates. The microspheres were characterized by Fourier transform infrared. The results suggested that the alginate/chitosan/starch microcapsules could be a suitable copolymeric carrier system for intestinal protein or peptides delivery in the intestine.
Zhang
Li
L
Department of Pharmaceutics, Marine College, Shandong University at Weihai, Weihai, China. tinazhang@sdu.edu.cn
Liu
Yezhou
Y
Wu
Zhongchen
Z
Chen
Haixu
H
D000464:Alginates / Q000737:chemistry; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000302:isolation & purification; D002214:Capsules; D048271:Chitosan / Q000737:chemistry; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007419:Intestinal Secretions / Q000378:metabolism; D010125:Ostreidae / Q000737:chemistry*; D010455:Peptides / Q000008:administration & dosage* / Q000302:isolation & purification; D017550:Spectroscopy, Fourier Transform Infrared; D013213:Starch / Q000737:chemistry; D013997:Time Factors
D000464:Alginates; D000890:Anti-Infective Agents; D002214:Capsules; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006603:Hexuronic Acids; D010455:Peptides; D020723:Glucuronic Acid; D013213:Starch; D048271:Chitosan