[Changes of the event related potential P300 following topiramate treatment in children with epilepsy].
OBJECTIVE
The event related potential (ERP-P300) is useful to determine cognitive disturbances. This study examined the changes of ERP-P300 following different dosages of topiramate (TPM) treatment in children with epilepsy in order to investigate the effect of different dosages of TPM on cognitive function.


METHODS
Thirty cases of benign childhood epilepsy with centrotemporal spikes (BECTS) were first administered with TPM at a dosage of 2 mg/kg/d for 6 months. Afterwards they received another 6 months of TPM treatment at a dosage of 5 mg/kg/d. ERP-P300 was tested before and after different dosages of TPM treatment.


RESULTS
There were no significant differences in the latency and amplitude of ERP-P300 before and after 6 months low dosages of TPM treatment. However, the latency was more prolonged and the amplitude was reduced in the ERP-P300 testing after 6 months high dosage of TMP treatment (P<0.01).


CONCLUSIONS
The effect of TPM on cognitive function is related to its dosage in children with epilepsy.
Yang
Wen
W
Department of Pediatrics, First People's Hospital of Changzhou, Changzhou, Jiangsu 213003, China. yangwen811@163.com
Li
Mei
M
D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use*; D002648:Child; D003071:Cognition / Q000187:drug effects*; D004827:Epilepsy / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D018913:Event-Related Potentials, P300 / Q000187:drug effects*; D005260:Female; D005632:Fructose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011930:Reaction Time / Q000187:drug effects; D000077236:Topiramate
D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose