Reabsorption of ascites and the factors that affect this process in cirrhosis.
Ascites is one of the main features of liver decompensation in cirrhosis, and it is considered to be a dynamic process. In this study, we aimed to (1) measure the reabsorption rate of ascites; (2) evaluate whether these findings were related to features of ascites, hemodynamics, and serum measurements; and (3) examine morphologic changes in the diaphragm of cirrhotic patients. In all, 42 cirrhotic patients with ascites were enrolled in the study to comprise our study group. Using the dextran 70 test, patient ascites volumes and reabsorption rates were measured. Biopsies from the peritoneal side of the diaphragm were also processed for scanning electron microscopy and lymphatic immunohistochemical studies from the cirrhotic patients and control cadavers. The mean ascites reabsorption rate was 4.5 +/- 4.5 (0.18-14.6) mL/min, which correlated significantly with the calculated ascites volume (r = 0.75, P < 0.001). The mean ascites viscosity was 1.07 +/- 0.07 (0.99-1.17) centipoise, which demonstrated a high degree of negative correlation with the ascites reabsorption rate (r = -0.77, P < 0.001). Patients with a history of spontaneous bacterial peritonitis had significantly lesser ascites reabsorption rates than patients without this particular history. The size of lymphatic stomata in scanning electron microscopy depictions was increased, and lymphatic lacunae were dilated in immunohistochemical studies in the cirrhotic patients with ascites. However, these findings were not uniform in every cirrhotic patient with ascites. The volume and viscosity of ascites seem to influence its reabsorption rate. Additionally, previous episodes of spontaneous bacterial peritonitis may be responsible for the decreased ascites reabsorption rates observed in certain patient populations.
Akay
Sinan
S
Gastroenterology Department, General Surgery Department, Center for Drug R&D and Pharmacokinetic Applications, Histology Department, Pathology Department, and Anesthesiology and Reanimation Department, Ege University Hospital, Bornova, Izmir, Turkey. sinanakay72@hotmail.com
Ozutemiz
Omer
O
Kilic
Murat
M
Karasu
Zeki
Z
Akyildiz
Murat
M
Karasulu
Ercument
E
Baka
Meral
M
Doganavsargil
Basak
B
Ersoz
Galip
G
Ulukaya
Sezgin
S
Alper
Isik
I
Ates
Utku
U
Batur
Yucel
Y
D000042:Absorption; D001202:Ascitic Fluid / Q000378:metabolism* / Q000473:pathology; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D003911:Dextrans; D003964:Diaphragm / Q000648:ultrastructure; D004039:Diet, Sodium-Restricted; D042783:Endothelial Cells / Q000737:chemistry / Q000473:pathology; D006439:Hemodynamics; D006801:Humans; D008103:Liver Cirrhosis / Q000178:diet therapy / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D042601:Lymphatic Vessels / Q000737:chemistry / Q000473:pathology
D015415:Biomarkers; D003911:Dextrans