[Immunohistochemical markers as prognosticators in gynecologic oncology].
Cyclooxygenase and particularly COX-2 expression impaired survival in patients operated on for endometrial adenocarcinoma of the uterus: 5-year overall and relapse-free survival in absence of expression was 92% and 88%, respectively, while in cases of distinct expression, it fell down to 52% and 48%, respectively (p = 0.0004; 0.0005). Similar correlations were observed for COX-1, although with lower significance (p = 0.02). Particularly unfavorable prognosis is associated with high expression of combination of COX-2 and COX-1. The end-results of radiotherapy were associated with proliferative levels of squamous cell cervical carcinoma: for Ki-67--below median of < or = 50%, 5-year survival rate was 77%, mean survival--80 months; for Ki-67 above median of > or = 50%, the indices were 47% and 47 months, respectively, (p = 0.002). There were similar correlations for mutated suppressor-gene 53: 67%--for absence of expression and 53%--for its presence (p = 0/03). Immunohistochemical markers COX-2, Ki-67 and p53 can be used as sole prognosticators and their predictive significance is higher than that of either stage (II or III) or cell differentiation grading.
Pozharisskiĭ
K M
KM
Vinokurov
V L
VL
Zharinov
G M
GM
Bolbarian
N A
NA
Kuznetsova
M E
ME
Gasparian
N A
NA
Samsonova
E A
EA
D000230:Adenocarcinoma / Q000737:chemistry / Q000175:diagnosis; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D051545:Cyclooxygenase 1 / Q000032:analysis; D051546:Cyclooxygenase 2 / Q000032:analysis; D018572:Disease-Free Survival; D016889:Endometrial Neoplasms / Q000737:chemistry / Q000175:diagnosis; D005260:Female; D018507:Gene Expression Regulation, Developmental; D015972:Gene Expression Regulation, Neoplastic; D005833:Genital Neoplasms, Female / Q000737:chemistry* / Q000175:diagnosis*; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D019394:Ki-67 Antigen / Q000032:analysis; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011379:Prognosis; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2