title: Lifetime total physical activity and prostate cancer risk: a population-based case-control study in Sweden.
abstract: The etiologic role of physical activity in prostate cancer development is unclear. We assessed the association between lifetime total physical activity and prostate cancer risk in a Swedish population-based case-control study comprising 1,449 incident prostate cancer cases and 1,118 unaffected population controls. Information regarding physical activity was obtained via a self-administered questionnaire assessing occupational, household, and recreational activity separately at various ages throughout an individual's lifetime. Clinical data (TNM-classification, Gleason sum and PSA) was obtained from linkage to the National Prostate Cancer Registry. Overall, we observed no association between lifetime total physical activity and prostate cancer risk (odds ratio [OR] = 1.04, 95% confidence interval [CI] = 0.77-1.41 for > or =49.7 vs. <41.9 metabolic equivalent-hours per day). There was a significantly increased risk of prostate cancer in the most active men compared with the least active men in household (OR = 1.44, 95% CI = 1.08-1.92) and recreational physical activity (OR = 1.56, 95% CI = 1.16-2.10). Comparing the most active with the least active men, total physical activity was not associated with either localized disease (OR = 0.95, 95% CI = 0.67-1.34) or advanced disease (OR = 1.19, 95% CI = 0.83-1.71). These findings do not support the hypothesis that physical activity uniformly protects against prostate cancer development.
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171-77, Stockholm, Sweden. fredrik.wiklund@ki.se
authors.forename: Fredrik
authors.initials: F
authors.lastname: Wiklund
authors.forename: Ylva Trolle
authors.initials: YT
authors.lastname: Lageros
authors.forename: Ellen
authors.initials: E
authors.lastname: Chang
authors.forename: Katarina
authors.initials: K
authors.lastname: Bälter
authors.forename: Jan-Erik
authors.initials: JE
authors.lastname: Johansson
authors.forename: Hans-Olov
authors.initials: HO
authors.lastname: Adami
authors.forename: Henrik
authors.initials: H
authors.lastname: Grönberg
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D015444:Exercise; D006801:Humans; D007899:Leisure Activities; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000517:prevention & control*; D018570:Risk Assessment; D011795:Surveys and Questionnaires; D013548:Sweden / Q000453:epidemiology