Stroke outcome in clinical trial patients deriving from different countries.
OBJECTIVE
Stroke incidence and outcome vary widely within and across geographical locations. We examined whether differences in index stroke severity, stroke risk factors, mortality, and stroke outcome across geographical locations remain after adjusting for case mix.


METHODS
We analyzed 3284 patients from the Virtual International Stroke Trials Archive (VISTA). We used logistic regression to examine the incidence of mild index stroke, functional, and neurological outcomes after accounting for age, medical history, year of trial recruitment, and initial stroke severity in the functional and neurological outcome analyses. We examined mortality between geographical regions using a Cox proportional hazards model, accounting for age, initial stroke severity, medical history, and year of trial recruitment.


RESULTS
Patients enrolled in the USA and Canada had the most severe index strokes. Those recruited in Austria and Switzerland had the best functional and neurological outcomes at 90 days (P<0.05), whereas those enrolled in Germany had the worst functional outcome at 90 days (P=0.013). Patients enrolled in Austria, Switzerland, Belgium, Netherlands, Finland, Germany, Greece, Israel, Spain, and Portugal had a significantly better survival rate when compared with those enrolled in USA and Canada. Patients enrolled in trials after 1998 had more severe index strokes, with no significant difference in outcome compared with those enrolled before 1998.


CONCLUSIONS
We identified regional variations in index stroke severity, outcome, and mortality for patients enrolled in ischemic stroke clinical trials over the past 13 years that were not fully explained by case mix. Index stroke severity was greater in patients enrolled after 1998, with no significant improvement in outcomes compared to those enrolled before 1998.
Ali
Myzoon
M
Division of Cardiovascular and Medical Sciences, University Department of Medicine & Therapeutics, Gardiner Institute, 44 Church St, Glasgow G11 6NT, UK. myzoonali@clinmed.gla.ac.uk
Atula
Sari
S
Bath
Philip M W
PM
Grotta
James
J
Hacke
Werner
W
Lyden
Patrick
P
Marler
John R
JR
Sacco
Ralph L
RL
Lees
Kennedy R
KR
D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002170:Canada / Q000453:epidemiology; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data; D004185:Disability Evaluation; D005060:Europe / Q000453:epidemiology; D005260:Female; D014943:Global Health; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009026:Mortality / Q000639:trends; D017063:Outcome Assessment, Health Care; D016016:Proportional Hazards Models; D012720:Severity of Illness Index; D020521:Stroke / Q000188:drug therapy* / Q000401:mortality* / Q000503:physiopathology; D015996:Survival Rate / Q000639:trends; D013997:Time Factors; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology