title: Membrane phospholipid synthesis and endoplasmic reticulum function.
abstract: This review presents an overview of mammalian phospholipid synthesis and the cellular locations of the biochemical activities that produce membrane lipid molecular species. The generalized endoplasmic reticulum compartment is a central site for membrane lipid biogenesis, and examples of the emerging relationships between alterations in lipid composition, regulation of membrane lipid biogenesis, and cellular secretory function are discussed.
authors.affiliation: Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105-3678, USA.
authors.forename: Paolo
authors.initials: P
authors.lastname: Fagone
authors.forename: Suzanne
authors.initials: S
authors.lastname: Jackowski
mesh_terms: D000818:Animals; D004721:Endoplasmic Reticulum / Q000737:chemistry / Q000378:metabolism*; D006056:Golgi Apparatus / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism*; D010743:Phospholipids / Q000096:biosynthesis* / Q000378:metabolism
chemical_list: D008563:Membrane Lipids; D010743:Phospholipids