title: Evolutionary footprints of nucleosome positions in yeast.
abstract: Using genome-wide maps of nucleosome positions in yeast, we have analyzed the influence of chromatin structure on the molecular evolution of genomic DNA. We have observed, on average, 10-15% lower substitution rates in linker regions than in nucleosomal DNA. This widespread local rate heterogeneity represents an evolutionary footprint of nucleosome positions and reveals that nucleosome organization is a genomic feature conserved over evolutionary timescales.
authors.affiliation: European Molecular Biology Laboratory - European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK. washietl@ebi.ac.uk
authors.forename: Stefan
authors.initials: S
authors.lastname: Washietl
authors.forename: Rainer
authors.initials: R
authors.lastname: Machné
authors.forename: Nick
authors.initials: N
authors.lastname: Goldman
mesh_terms: D001482:Base Composition; D017124:Conserved Sequence; D021901:DNA, Intergenic / Q000235:genetics; D019143:Evolution, Molecular; D009154:Mutation / Q000235:genetics; D009707:Nucleosomes / Q000235:genetics*; D016366:Open Reading Frames / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000235:genetics*
chemical_list: D021901:DNA, Intergenic; D009707:Nucleosomes