Energetics of kinesin-1 stepping mechanism.
Kinesin-1 is a dimeric motor protein that transports cellular cargo along microtubules by using the energy released from ATP hydrolysis and moving processively in 8-nm steps. Recent novel studies at the single molecular level have provided extensive knowledge on how kinesin-1 converts the free energy of ATP hydrolysis and uses it for "walking" along microtubules. In this review, I have discussed the important topics pertaining to the energetics of kinesin-1 stepping mechanism and the consensus walking model.
Kawaguchi
Kenji
K
Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. z4m1098@students.chiba-u.jp
D000255:Adenosine Triphosphate / Q000378:metabolism; D000595:Amino Acid Sequence; D016547:Kinesins / Q000737:chemistry / Q000378:metabolism*; D009038:Motion
D000255:Adenosine Triphosphate; D016547:Kinesins