Association of mitochondrial haplogroup J and mtDNA oxidative damage in two different North Spain elderly populations.
This work investigates the association between longevity, mitochondrial DNA (mtDNA) variants and oxidative DNA damage in an older than 85 years population. The participants, similar in genetic and cultural background as well as gender distribution, come from villages near to the Pyrenees Mountains (900-1,400 m altitude) (n = 69) and the Ebro's Valley (200-300 m altitude) (n = 69) in Spain. Our results show an accumulation of the haplogroup J in elderly individuals with an over-representation of J2 in Pyrenees group but not in the Ebro's Valley, the former associating with a diminished DNA damage. In conclusion, our results suggest that J mitochondrial variant, that induce lower mtDNA damage, could present a phenotypic survival advantage to environmental conditions and, thus, accumulate in elderly population.
Domínguez-Garrido
Elena
E
Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, Zaragoza, Spain.
Martínez-Redondo
Diana
D
Martín-Ruiz
Carmen
C
Gómez-Durán
Aurora
A
Ruiz-Pesini
Eduardo
E
Madero
Pilar
P
Tamparillas
Manuel
M
Montoya
Julio
J
von Zglinicki
Thomas
T
Díez-Sánchez
Carmen
C
López-Pérez
Manuel J
MJ
D000064:Acclimatization / Q000235:genetics; D000328:Adult; D000367:Age Factors; D000369:Aged, 80 and over; D000531:Altitude; D016022:Case-Control Studies; D004249:DNA Damage; D004272:DNA, Mitochondrial / Q000378:metabolism*; D005260:Female; D006239:Haplotypes; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008297:Male; D018384:Oxidative Stress / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic; D013030:Spain; D055815:Young Adult
D004272:DNA, Mitochondrial