Synthesis and antiviral activity of novel pyrazole derivatives containing oxime esters group.
Fourteen title compounds, 1-substituted-5-substitutedphenylthio-4-pyrazolaldoxime ester derivatives 4a-4n, were synthesized from the starting material 1-substitutedphenyl-3-methyl-5-substitutedphenylthio-4-pyrazolaldoximes 3 by treatment with acyl chloride. The synthesized compounds were characterized by physical constants, and the structures of the title compounds were further confirmed by IR, 1H NMR, 13C NMR and elemental analysis. The bioassay results showed that title compounds possessed weak to good anti-TMV bioactivity with 4l showing significant enhancement of disease resistance in tobacco leaves with high affinity for TMV CP.
Ouyang
Guiping
G
Center for Research and Development of Fine Chemicals, Key Laboratory of Green Pesticide and Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, PR China.
Chen
Zhuo
Z
Cai
Xue-Jian
XJ
Song
Bao-An
BA
Bhadury
Pinaki S
PS
Yang
Song
S
Jin
Lin-Hong
LH
Xue
Wei
W
Hu
De-Yu
DY
Zeng
Song
S
D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D010091:Oximes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000378:metabolism / Q000821:virology; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012313:RNA / Q000032:analysis / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014026:Nicotiana / Q000378:metabolism / Q000821:virology; D014027:Tobacco Mosaic Virus / Q000187:drug effects
D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D004952:Esters; D010091:Oximes; D011720:Pyrazoles; D012313:RNA