title: Deferasirox plus ciprofloxacin combination therapy after rapid diagnosis of Vibrio vulnificus sepsis using real-time polymerase chain reaction.
abstract: We report a case of Vibrio vulnificus sepsis developed during deferoxamine therapy for transfusional iron overload due to secondary hemochromatosis of myelodysplastic syndrome. The patient was treated with adjuvant deferasirox in combination with ciprofloxacin, after rapid diagnosis of V. vulnificus sepsis using real-time polymerase chain reaction (PCR). This case suggests that since V. vulnificus DNA can be detected by real-time PCR for several days even after patients receive antibiotics, real-time PCR for V. vulnificus is a very useful test for establishing an early diagnosis, even if a patient has been treated with antibiotics prior to admission.
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, Chosun University College of Medicine, Clinical Research Institute, Gwang-ju, South Korea.
authors.forename: Dong-Min
authors.initials: DM
authors.lastname: Kim
authors.forename: Hong Sung
authors.initials: HS
authors.lastname: Cho
authors.forename: Ji-In
authors.initials: JI
authors.lastname: Kang
authors.forename: Hyong Sun
authors.initials: HS
authors.lastname: Kim
authors.forename: Chi Young
authors.initials: CY
authors.lastname: Park
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001565:Benzoates / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000627:therapeutic use*; D004269:DNA, Bacterial / Q000235:genetics; D000077588:Deferasirox; D004359:Drug Therapy, Combination; D005260:Female; D006432:Hemochromatosis / Q000150:complications; D006801:Humans; D016133:Polymerase Chain Reaction / Q000379:methods; D018805:Sepsis / Q000188:drug therapy* / Q000382:microbiology; D014230:Triazoles / Q000627:therapeutic use*; D014735:Vibrio Infections / Q000175:diagnosis* / Q000188:drug therapy*; D041261:Vibrio vulnificus / Q000302:isolation & purification*
chemical_list: D000900:Anti-Bacterial Agents; D001565:Benzoates; D004269:DNA, Bacterial; D014230:Triazoles; D002939:Ciprofloxacin; D000077588:Deferasirox