title: Mapping quantitative trait Loci for left-sided displacement of the abomasum in German Holstein dairy cows.
abstract: A whole-genome scan using an affected paternal half-sib design was utilized to detect quantitative trait loci (QTL) for left-sided displaced abomasum (LDA) in German Holsteins. A total of 360 animals from 14 paternal half-sib families were genotyped, for a total of 306 polymorphic microsatellites. For a whole-genome scan, 221 markers were equally distributed over all 29 bovine autosomes, with an average distance of 13.7 cM. For fine-mapping, a total of 85 additional microsatellites were used. We identified genome-wide significant QTL on Bos taurus autosome (BTA) 1 (54.6 to 58.3 cM) and on BTA3 (5.9 cM). Furthermore, 3 chromosome-wide significant QTL were located on bovine chromosomes 21, 23, and 24. In addition, we found 11 QTL that cosegregated in grandsire families but that were not significant in the across-family analysis. These QTL were located on BTA5, 6, 10, 12, 15, 16, 17, 19, 23, and 26. This study is the first report on QTL for LDA and is a first step toward identifying single nucleotide polymorphisms for LDA-QTL.
authors.affiliation: Institute for Animal Breeding and Genetics, University for Veterinary Medicine Hannover, 30559 Hannover, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Mömke
authors.forename: H
authors.initials: H
authors.lastname: Scholz
authors.forename: K
authors.initials: K
authors.lastname: Doll
authors.forename: J
authors.initials: J
authors.lastname: Rehage
authors.forename: O
authors.initials: O
authors.lastname: Distl
mesh_terms: D000018:Abomasum / Q000002:abnormalities*; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000235:genetics*; D002874:Chromosome Mapping; D003612:Dairying; D005260:Female; D016678:Genome / Q000235:genetics; D005858:Germany; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D040641:Quantitative Trait Loci / Q000235:genetics*; D013272:Stomach Diseases / Q000235:genetics / Q000662:veterinary*