title: Feedback loops shape cellular signals in space and time.
abstract: Positive and negative feedback loops are common regulatory elements in biological signaling systems. We discuss core feedback motifs that have distinct roles in shaping signaling responses in space and time. We also discuss approaches to experimentally investigate feedback loops in signaling systems.
authors.affiliation: Department of Cellular and Molecular Pharmacology, University of California-San Francisco and Howard Hughes Medical Institute, San Francisco, CA 94158, USA. Onn.Brandman@ucsf.edu
authors.forename: Onn
authors.initials: O
authors.lastname: Brandman
authors.forename: Tobias
authors.initials: T
authors.lastname: Meyer
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling; D002462:Cell Membrane / Q000378:metabolism; D002634:Chemotaxis, Leukocyte; D003198:Computer Simulation; D004721:Endoplasmic Reticulum / Q000378:metabolism; D025461:Feedback, Physiological; D008954:Models, Biological; D009504:Neutrophils / Q000378:metabolism* / Q000502:physiology; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D019869:Phosphatidylinositol 3-Kinases; D002118:Calcium