title: Case fatality of stroke and day of the week: is the weekend effect an artifact? Takashima stroke registry, Japan (1988-2003).
abstract: OBJECTIVE
  For stroke admissions, the 'weekend effect' has been associated with higher stroke fatality. However, it is unclear if stroke case fatality shows this pattern if the onset day is taken into account. Day of the week variation in stroke case fatality was examined using 16-year stroke registration data.
  
  
  METHODS
  Data were obtained from Takashima Stroke Registry in central Japan. There were 1,578 registered first-ever cerebral infarction and cerebral hemorrhage stroke cases during 1988-2003. We divided the days into 2 groups: 'weekend' and 'weekdays'. The 7-day and 28-day case fatality rates and 95% confidence intervals (95% CI) were calculated by gender, age and stroke subtype.
  
  
  RESULTS
  For all strokes, the 7-day case fatality rate based on the hospital admission day was 9.5% (95% CI: 6.8-13.1) for weekend admissions and 7.3% (95% CI: 6.0-8.9) for weekday admissions. However, case fatality rates based on the onset day were 7.2% (95% CI: 5.1-10.0) for weekend onset and 8.0% (95% CI: 6.6-9.8) for weekday onset. The 28-day case fatality rate for the weekend admission group was 14.7% (95% CI: 11.3-18.8) and for the weekday admission group it was 10.1% (95% CI: 8.5-11.9). In contrast, the 28-day case fatality rate for the weekend onset group was 11.3% (95% CI: 8.6-14.7) and for the weekday onset group it was 11.0% (95% CI: 9.3-13.0). This phenomenon was observed mainly for cerebral infarction and to some extent for cerebral hemorrhage.
  
  
  CONCLUSIONS
  Stroke fatality rates based on the day of admission were higher during the weekend than weekdays, although the difference did not reach statistical significance. However, this trend disappeared when the fatality rate was based on the day of onset.
authors.affiliation: Department of Health Science, Shiga University of Medical Science, Otsu, Japan. turin@belle.shiga-med.ac.jp
authors.forename: Tanvir Chowdhury
authors.initials: TC
authors.lastname: Turin
authors.forename: Yoshikuni
authors.initials: Y
authors.lastname: Kita
authors.forename: Nahid
authors.initials: N
authors.lastname: Rumana
authors.forename: Masaharu
authors.initials: M
authors.lastname: Ichikawa
authors.forename: Hideki
authors.initials: H
authors.lastname: Sugihara
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Morita
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Tomioka
authors.forename: Akira
authors.initials: A
authors.lastname: Okayama
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Ueshima
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016477:Artifacts; D002543:Cerebral Hemorrhage / Q000401:mortality; D002544:Cerebral Infarction / Q000401:mortality; D005260:Female; D006693:Holidays; D017052:Hospital Mortality; D006801:Humans; D007564:Japan / Q000453:epidemiology; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D010343:Patient Admission / Q000706:statistics & numerical data; D012042:Registries; D020521:Stroke / Q000401:mortality*; D013997:Time Factors