New light on an age-old issue.
In this issue, Varadhan and colleagues propose a methodologic framework that seeks to quantify impaired resiliency in dynamic systems underlying the frailty syndrome. We view this work, which is based on modeling stimulus-response data, as an exciting expansion of longstanding theories of age-related decline in physiologic reserve across systems. We outline ways in which this methodology might make substantial contributions in frailty research and clinical practice, and we discuss potential obstacles in its operationalization.
Whitson
Heather E
HE
Center for the Study of Aging and Human Development, Department of Medicine, Duke University Medical Center, Durham, NC 27707, USA. heather.whitson@duke.edu
Pieper
Carl F
CF
Cohen
Harvey J
HJ
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D015415:Biomarkers / Q000378:metabolism; D004198:Disease Susceptibility; D025461:Feedback, Physiological; D016330:Frail Elderly; D006706:Homeostasis; D006801:Humans; D008954:Models, Biological; D010641:Phenotype; D015203:Reproducibility of Results; D013312:Stress, Physiological; D049490:Systems Biology; D013997:Time Factors
D015415:Biomarkers