An efficient synthesis of chiral phosphinyl oxide pyrrolidines and their application to asymmetric direct aldol reactions.
Chiral pyrrolidine-based phosphinyl oxides were synthesized and their performance as organocatalysts for asymmetric direct aldol reactions was evaluated. High enantioselectivities and diastereoselectivies were achieved for a range of cyclic ketones and aromatic aldehydes.
Liu
Xue-Wei
XW
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 637371, Singapore. xuewei@ntu.edu.sg
Le
Thanh Nguyen
TN
Lu
Yunpeng
Y
Xiao
Yongjun
Y
Ma
Jimei
J
Li
Xingwei
X