title: A facile synthesis of alpha,alpha'-(EE)-bis(benzylidene)-cycloalkanones and their antitubercular evaluations.
abstract: An economical and facile synthesis of alpha,alpha'-(EE)-bis(benzylidene)-cycloalkanones was achieved by the reaction of cycloalkanones with different aromatic aldehydes using ethanolic KOH in good yields. Few of the selected compounds were reduced with NaBH(4) to the respective alpha,alpha'-(EE)-bis(benzylidene)-cycloalkanols. All these compounds and our earlier synthesized cyclohexyl phenyl methanols were evaluated for their antitubercular, antifungal and antibacterial activities. Several compounds displayed moderate antitubercular activity with MIC=12.5-1.56 microg/mL. However, none of the compounds displayed any significant antifungal activity.
authors.affiliation: Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, India.
authors.forename: Nimisha
authors.initials: N
authors.lastname: Singh
authors.forename: Jyoti
authors.initials: J
authors.lastname: Pandey
authors.forename: Amit
authors.initials: A
authors.lastname: Yadav
authors.forename: Vinita
authors.initials: V
authors.lastname: Chaturvedi
authors.forename: Shalini
authors.initials: S
authors.lastname: Bhatnagar
authors.forename: Anil N
authors.initials: AN
authors.lastname: Gaikwad
authors.forename: Sudhir Kumar
authors.initials: SK
authors.lastname: Sinha
authors.forename: Awaneet
authors.initials: A
authors.lastname: Kumar
authors.forename: P K
authors.initials: PK
authors.lastname: Shukla
authors.forename: Rama P
authors.initials: RP
authors.lastname: Tripathi
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*
chemical_list: D000438:Alcohols; D000995:Antitubercular Agents