Nitroaromatic actuation of mitochondrial bioelectrocatalysis for self-powered explosive sensors.
Oligomycin-inhibited mitochondria-modified electrodes were used to electrochemically sense the presence of nitroaromatics owing to the selective ability of nitroaromatics to decouple the inhibition of pyruvate metabolism by the mitochondria. These oligomycin inhibited mitochondria-modified electrodes were employed as the bioanode in a pyruvate/air biofuel cell. This sensing mechanism could be used as a traditional electrochemical sensor or as a self-powered sensor.
Germain
Marguerite N
MN
Saint Louis University, Department of Chemistry 3501 Laclede Avenue, St. Louis, Missouri 63103, USA.
Arechederra
Robert L
RL
Minteer
Shelley D
SD
D055162:Biocatalysis; D004566:Electrodes; D004583:Electrons; D008928:Mitochondria / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism*; D009574:Nitro Compounds / Q000737:chemistry*; D009840:Oligomycins / Q000494:pharmacology
D009574:Nitro Compounds; D009840:Oligomycins