Characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates in China.
Thirteen extensively drug-resistant tuberculosis isolates which were highly resistant to a broad spectrum of antituberculosis drugs were identified from 1,926 clinical isolates in China. They had highly diverse mycobacterial interspersed repetitive-unit-variable-number tandem-repeat patterns. Most, but not all, of the drug target genes had mutations contributing to resistance to the corresponding drug.
Sun
Zhaogang
Z
Department of Bacteriology and Immunology, Beijing Tuberculosis & Thoracic Tumor Research Institute, Tongzhou District, Beijing, China.
Chao
Yanjie
Y
Zhang
Xuxia
X
Zhang
Jianyuan
J
Li
Yan
Y
Qiu
Yunqing
Y
Liu
Yi
Y
Nie
Lihui
L
Guo
Aizhen
A
Li
Chuanyou
C
D000328:Adult; D000995:Antitubercular Agents / Q000494:pharmacology; D002681:China; D016172:DNA Fingerprinting; D004269:DNA, Bacterial / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial; D054908:Extensively Drug-Resistant Tuberculosis / Q000382:microbiology*; D005260:Female; D005798:Genes, Bacterial; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats / Q000235:genetics*; D020125:Mutation, Missense; D009169:Mycobacterium tuberculosis / Q000145:classification* / Q000187:drug effects / Q000302:isolation & purification*
D000995:Antitubercular Agents; D004269:DNA, Bacterial