Zinc-mediated allylation and alkylation of aminals in the presence of TMSCl and diisopropylamine.
An alkylation of aminals with organozinc reagents derived from allyl bromide, benzyl bromide, alpha-bromoacetate, and alpha-bromonitrile proceeded efficiently in the presence of TMSCl and diisopropylamine. This reaction system was applied to the synthesis of an antispasmodic: butaverine.
Hatano
Bunpei
B
Division of Chemistry, Graduate School of Science and Engineering, Yamagata University, 4-3-16 Jonan, Yonezawa, 992-8510, Japan. hatano@yz.yamagata-u.ac.jp
Nagahashi
Keita
K
Kijima
Tatsuro
T