title: Preimplantation genetic screening in a case of recurrent trisomy 21 offspring.
abstract: OBJECTIVE
  To describe a unique case of recurrent aneuploidy and the use of preimplantation genetic screening (PGS).
  
  
  METHODS
  Case report.
  
  
  METHODS
  Midwest academic medical center.
  
  
  METHODS
  A 36-year-old woman with two trisomy 21 offspring.
  
  
  METHODS
  Preimplantation genetic screening.
  
  
  METHODS
  Karyotype of embryos, liveborn eukaryotic infant.
  
  
  RESULTS
  Preimplantation genetic screening was performed on three cryopreserved embryos, followed by a two-embryo transfer yielding a eukaryotic infant.
  
  
  CONCLUSIONS
  Preimplantation genetic screening may prove to be useful as a diagnostic tool to help ensure a euploid pregnancy when termination is not a viable option for a couple.
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Mayo Clinic, Rochester, Minnesota 55905, USA. hudson.susan@mayo.edu
authors.forename: Susan B A
authors.initials: SB
authors.lastname: Hudson
authors.forename: Charles C
authors.initials: CC
authors.lastname: Coddington
authors.forename: David L
authors.initials: DL
authors.lastname: Walker
authors.forename: Jolene R
authors.initials: JR
authors.lastname: Fredrickson
authors.forename: Dean E
authors.initials: DE
authors.lastname: Morbeck
mesh_terms: D000328:Adult; D015925:Cryopreservation; D004314:Down Syndrome / Q000175:diagnosis* / Q000235:genetics; D004624:Embryo Transfer; D004622:Embryo, Mammalian; D005260:Female; D005820:Genetic Testing; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D050498:Live Birth; D011247:Pregnancy; D019836:Preimplantation Diagnosis