title: Candida tropicalis arthritis in a patient with acute leukemia.
abstract: Candida arthritis in patient with hematological malignancy is rare. A case of Candida tropicalis arthritis of knee occurred in a patient with acute monocytic leukemia was reported during the recovery phase of post chemotherapy myelosuppression and agranulocytosis. The patient was diagnosed as Candida tropicalis arthritis of knee according to the Candida tropicalis isolated from the synovial fluid. Itraconazole and amphotericin B were intravenously injected for therapy for 4 - 5 weeks based on the susceptibility test in vitro, which showed better efficacy. But the arthritis relapsed at 4 - 6 weeks after the drug withdrawal. The curative effect was found in patient after treatment with fluconazole injection and articular cavity douching with amphotericin B for 8 weeks. In conclusion, although Candida arthritis in patient with hematological malignancy is rare, it still occurred in the patient with hypoimmunity. The treatment emphasis showed be placed on the full dosage and full treatment course of antifungal agent.
authors.affiliation: Bone Marrow Transplantation Center, The First Hospital, Zhejiang University Midical College, Hangzhou 310003, Zhejiang Province, China.
authors.forename: Xiao-Rong
authors.initials: XR
authors.lastname: Hu
authors.forename: Jing-Song
authors.initials: JS
authors.lastname: He
authors.forename: Xiu-Jin
authors.initials: XJ
authors.lastname: Ye
authors.forename: Wei-Yan
authors.initials: WY
authors.lastname: Zheng
authors.forename: Wen-Jun
authors.initials: WJ
authors.lastname: Wu
authors.forename: Mao-Fang
authors.initials: MF
authors.lastname: Lin
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D001170:Arthritis, Infectious / Q000188:drug therapy / Q000382:microbiology*; D041022:Candida tropicalis / Q000302:isolation & purification; D002177:Candidiasis / Q000188:drug therapy; D005260:Female; D006801:Humans; D007938:Leukemia / Q000382:microbiology*; D008875:Middle Aged
chemical_list: D000935:Antifungal Agents