title: Treatment of sinus headache as migraine: the diagnostic utility of triptans.
abstract: OBJECTIVE
  To determine the response rate to triptans in alleviating "sinus headache" in patients with endoscopy- and computed tomography (CT)-negative sinus examinations.
  
  
  METHODS
  Prospective clinical trial.
  
  
  METHODS
  Patients who presented to a tertiary care center Otolaryngology Department with primary complaints of facial pain, pressure, or headache localized over the area of the sinuses, and a self- or physician-diagnosis of "sinus headache" were enrolled. Patients underwent directed history, physical examination, rigid nasal endoscopy, a sinus CT scan, and completed a headache questionnaire. Those patients that had negative findings were treated empirically with triptans. Patients completed a headache diary for each headache, using a visual analogue scale to rate the headache before and after triptan use. Response was considered as significant improvement (greater than 50% reduction of pain), partial (25-50% reduction), and no response.
  
  
  RESULTS
  Fifty-four patients were enrolled. Thirty-eight (69%) completed follow-up, 63% were women. The mean age was 41 years (23-70). Thirty-one patients (82%) had significant reduction of headache pain with triptan use. Thirty-five patients (92%) had a significant reduction in headache pain in response to migraine-directed therapy. Seventeen patients (31%) withdrew or failed to follow-up, often reluctant to accept a diagnosis of migraine.
  
  
  CONCLUSIONS
  This study demonstrated that the demographics of patients with self-described "sinus headaches" who did not have findings of sinusitis on endoscopy and CT scan closely reflected the demographics of patients afflicted with migraines. It also showed that 82% of these patients had a significant response to empiric treatment for sinus headaches with triptans. These findings support that "sinus headaches" may represent migraines, and response to triptans may aid in diagnosis.
authors.affiliation: Department of Otolaryngology, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors.forename: Elina
authors.initials: E
authors.lastname: Kari
authors.forename: John M
authors.initials: JM
authors.lastname: DelGaudio
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D003937:Diagnosis, Differential; D019348:Empiricism; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D006261:Headache / Q000188:drug therapy* / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy* / Q000209:etiology*; D010147:Pain Measurement; D011446:Prospective Studies; D011759:Pyrrolidines / Q000009:adverse effects / Q000627:therapeutic use*; D012017:Referral and Consultation; D017366:Serotonin Receptor Agonists / Q000009:adverse effects / Q000627:therapeutic use*; D012852:Sinusitis / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014363:Tryptamines / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D011759:Pyrrolidines; D017366:Serotonin Receptor Agonists; D014363:Tryptamines; C115647:eletriptan