Genotoxicity testing of aqueous extracts of Mahwangyounpae-tang, a polyherbal formula.
Mahwangyounpae-tang (MT), consisting of 22 types of herbal extracts has been used for thousands of years in Korean traditional medicine for the oral treatment of respiratory diseases including asthma. As part of a safety evaluation of MT extracts for use in asthma, the potential genotoxicity of an aqueous MT extract was evaluated using the standard battery of tests (bacterial reverse mutation assay; chromosomal aberrations assay; mouse micronucleus assay) recommended by Korea Food and Drug Administration (KFDA). The MT extract was determined not to be genotoxic under the conditions of the reverse mutation assay, chromosomal aberrations assay and mouse micronucleus assay. Use of MT is presently expected to be safe, as anticipated intake is small compared to the doses administered in the genotoxicity assays and may, after further toxicity research, prove to be a useful anti-asthma agent.
Seo
Jeng-Yim
JY
Division of Respiratory System, Daegu Haany University, Gyeongsan 712-715, Republic of Korea.
Park
Mee-Yeon
MY
Jung
Tae-Young
TY
Choi
Hae-Yun
HY
Kim
Jong-Dae
JD
Lee
Hyeung-Sik
HS
Ku
Sae-Kwang
SK
D000818:Animals; D018927:Anti-Asthmatic Agents / Q000633:toxicity*; D002869:Chromosome Aberrations / Q000187:drug effects; D055670:Medicine, Korean Traditional; D051379:Mice; D008813:Mice, Inbred ICR; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D010936:Plant Extracts / Q000633:toxicity*; D051381:Rats; D014867:Water
D018927:Anti-Asthmatic Agents; D009153:Mutagens; D010936:Plant Extracts; C534470:mahwangyounpae-tang; D014867:Water