title: Scrapheap challenge and the single cell.
abstract: The prevailing approach to cellular molecular analyte investigations employs lysis. Using analogies with automobiles, we explain how current practise ridicules cellular individuality and meaningful variation. Single cell analysis and micro total analysis system (microTAS) prospects are discussed.
authors.affiliation: Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK M13 9PT.
authors.forename: Rupak
authors.initials: R
authors.lastname: Doshi
authors.forename: Philip J R
authors.initials: PJ
authors.lastname: Day
mesh_terms: D002469:Cell Separation; D002470:Cell Survival; D002477:Cells / Q000166:cytology*; D046208:Microchip Analytical Procedures; D036103:Nanotechnology