Oxidative burst inhibitory and cytotoxic indoloquinazoline and furoquinoline alkaloids from Oricia suaveolens.
Two new β-indoloquinazoline alkaloids, orisuaveoline A (1) and orisuaveoline B (2), two new furoquinoline alkaloids, quinosuaveoline A (5) and quinosuaveoline B (6), and 12 known compounds were isolated from Oricia suaveolens. The structures of the new compounds were deduced by spectroscopic studies. The absolute configuration of nkolbisine (4) was also determined. Compounds 2, 3, 6-8, 10, and 14 were evaluated for oxidative burst inhibitory activity in a chemoluminescence assay and for cytotoxicity against A549 lung carcinoma cells.
Wansi
Jean Duplex
JD
Department of Chemistry, University of Douala, Faculty of Science, P.O. Box 24157 Douala, Cameroon. jdwansi@yahoo.fr
Mesaik
M Ahmed
MA
Chiozem
David Dako
DD
Devkota
Krishna Prasad
KP
Gaboriaud-Kolar
Nicolas
N
Lallemand
Marie-Christine
MC
Wandji
Jean
J
Choudhary
M Iqbal
MI
Sewald
Norbert
N
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D011799:Quinazolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D011804:Quinolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D016897:Respiratory Burst / Q000187:drug effects*; D027821:Rutaceae / Q000737:chemistry*
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D005663:Furans; D007211:Indoles; D011799:Quinazolines; D011804:Quinolines; C475704:indolo(2,1-b)quinazoline; C568014:orisuaveoline A; C568015:orisuaveoline B; C568016:quinosuaveoline A; C568017:quinosuaveoline B