Smooth-muscle myosin mutations in hereditary non-polyposis colorectal cancer syndrome.
We examined adenomas and cancers from hereditary non-polyposis colorectal cancer (HNPCC) syndrome patients for the presence of frameshift mutations in the smooth-muscle myosin gene, MYH11. Our results show that mutations in MYH11 occur more frequently in cancers than adenomas (P=0.008) and are dependent on microsatellite instability (MSI+).
Vickaryous
N
N
Colorectal Cancer Genetics, Institute for Cell and Molecular Sciences, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Whitechapel, London, UK.
Polanco-Echeverry
G
G
Morrow
S
S
Suraweera
N
N
Thomas
H
H
Tomlinson
I
I
Silver
A
A
D000236:Adenoma / Q000235:genetics; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics*; D016368:Frameshift Mutation; D006801:Humans; D053842:Microsatellite Instability; D018995:Myosin Heavy Chains / Q000235:genetics*; D024745:Smooth Muscle Myosins / Q000235:genetics*
C509903:MYH11 protein, human; D024745:Smooth Muscle Myosins; D018995:Myosin Heavy Chains