Beneficial effects of curcumin on hyperlipidemia and insulin resistance in high-fat-fed hamsters.
This study investigated the effect of curcumin (0.05-g/100-g diet) supplementation on a high-fat diet (10% coconut oil, 0.2% cholesterol, wt/wt) fed to hamsters, one of the rodent species that are most closely related to humans in lipid metabolism. Curcumin significantly lowered the levels of free fatty acid, total cholesterol, triglyceride, and leptin and the homeostasis model assessment of insulin resistance index, whereas it elevated the levels of high-density lipoprotein cholesterol and apolipoprotein (apo) A-I and paraoxonase activity in plasma, compared with the control group. The levels of hepatic cholesterol and triglyceride were also lower in the curcumin group than in the control group. In the liver, fatty acid beta-oxidation activity was significantly higher in the curcumin group than in the control group, whereas fatty acid synthase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and acyl coenzyme A:cholesterol acyltransferase activities were significantly lower. Curcumin significantly lowered the lipid peroxide levels in the erythrocyte and liver compared with the control group. These results indicate that curcumin exhibits an obvious hypolipidemic effect by increasing plasma paraoxonase activity, ratios of high-density lipoprotein cholesterol to total cholesterol and of apo A-I to apo B, and hepatic fatty acid oxidation activity with simultaneous inhibition of hepatic fatty acid and cholesterol biosynthesis in high-fat-fed hamsters.
Jang
Eun-Mi
EM
Department of Nutrition Education, Graduate School of Education, Sunchon National University, Jeonnam 540-742, South Korea.
Choi
Myung-Sook
MS
Jung
Un Ju
UJ
Kim
Myung-Joo
MJ
Kim
Hye-Jin
HJ
Jeon
Seon-Min
SM
Shin
Su-Kyung
SK
Seong
Chi-Nam
CN
Lee
Mi-Kyung
MK
D000818:Animals; D016632:Apolipoprotein A-I / Q000097:blood; D043303:Aryldialkylphosphatase / Q000097:blood; D002318:Cardiovascular Diseases / Q000209:etiology; D008076:Cholesterol, HDL / Q000097:blood; D006224:Cricetinae; D003474:Curcumin / Q000494:pharmacology*; D004041:Dietary Fats / Q000008:administration & dosage; D005227:Fatty Acids / Q000096:biosynthesis; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood; D015227:Lipid Peroxidation; D008297:Male; D008647:Mesocricetus
D016632:Apolipoprotein A-I; D008076:Cholesterol, HDL; D004041:Dietary Fats; D005227:Fatty Acids; D000960:Hypolipidemic Agents; D020738:Leptin; D043303:Aryldialkylphosphatase; D003474:Curcumin