Posterior reversible encephalopathy syndrome after intravenous caffeine for post-lumbar puncture headaches.
A 33-year-old woman developed severe post-lumbar puncture headaches in the course of work-up for multiple sclerosis. Immediately after receiving treatment with intravenous caffeine, she became blind and experienced a generalized tonic-clonic seizure. Brain MR imaging then showed vasogenic parieto-occipital edema. She recovered clinically and radiologically within 72 hours. After 1 year of follow-up, there was no recurrence of symptoms or radiologic changes.
Ortiz
G A
GA
Department of Neurology, University of Miami Miller School of Medicine, Jackson Memorial Hospital, Miami, FL 33136, USA. gortiz2@med.miami.edu
Bianchi
N A
NA
Tiede
M P
MP
Bhatia
R G
RG
D000328:Adult; D001812:Blood-Brain Barrier / Q000187:drug effects; D001929:Brain Edema / Q000139:chemically induced* / Q000473:pathology; D002110:Caffeine / Q000008:administration & dosage / Q000009:adverse effects*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000009:adverse effects*; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced / Q000473:pathology; D005260:Female; D006261:Headache / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D007275:Injections, Intravenous; D008279:Magnetic Resonance Imaging; D013129:Spinal Puncture / Q000009:adverse effects
D000697:Central Nervous System Stimulants; D002110:Caffeine