Aseptic loosening of total hip arthroplasty: preliminary genetic investigation.
Femoral and acetabular loosening can be attributed different factors, but the causes and mechanism of early failure are still obscure. The objective of this study was to investigate the relationship between gene polymorphisms and early implant failure. Fifty-eight patients older than 50 years was recruited for analysis of MMP-1 promoter polymorphisms in early osseointegrated implant failure. The results showed in control group a frequency of 20.97% of 2G allele and 67.74% the genotype 1G/1G whereas, in the test group, a frequency of 83.33% of 2G allele and 66.66% the genotype 2G/2G. These results indicate that the polymorphism in the promoter of the MMP-1 gene could be a risk factor for early implant failure of total hip arthroplasty.
Godoy-Santos
Alexandre Leme
AL
Institute of Orthopedics and Traumatology, Hospital das Clínicas, University of São Paulo Medical School-São Paulo, Brazil.
D'Elia
Caio O
CO
Teixeira
William J
WJ
Cabrita
Henrique B
HB
Camanho
Gilberto L
GL
D019644:Arthroplasty, Replacement, Hip; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D011475:Prosthesis Failure; D012307:Risk Factors
D020781:Matrix Metalloproteinase 1