title: One-pot tandem decarboxylative allylation-Heck cyclization of allyl diphenylglycinate imines: rapid access to polyfunctionalized 1-aminoindanes.
abstract: 1-Aminoindanes are generated from allyl diphenylglycinate imines employing a "one-pot" palladium-catalyzed decarboxylative allylation-Heck cyclization cascade. Variation of both the aryl and allyl moieties leads to a diverse range of polycyclic imines, amenable to the synthesis of natural products and other biologically relevant small molecules.
authors.affiliation: Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904-4319, USA.
authors.forename: Wendy H
authors.initials: WH
authors.lastname: Fields
authors.forename: Ali K
authors.initials: AK
authors.lastname: Khan
authors.forename: Michal
authors.initials: M
authors.lastname: Sabat
authors.forename: Jason J
authors.initials: JJ
authors.lastname: Chruma
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D003653:Decarboxylation; D005998:Glycine / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D007189:Indans / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry; D013997:Time Factors
chemical_list: D000475:Alkenes; D007097:Imines; D007189:Indans; D010165:Palladium; D005998:Glycine