Expression of BCL10 is significantly associated with the progression and prognosis of oral squamous cell carcinomas in Taiwan.
This study used an immunohistochemical technique to examine the expression of BCL10 in 93 specimens of oral squamous cell carcinoma (OSCC) and 21 specimens of normal oral mucosa (NOM). We found a significant correlation between the higher mean BCL10 labeling index (LI) and OSCCs at the tongue, with larger tumor size, with positive lymph node metastasis, with more advanced clinical stages, or with recurrence (all p-values=0.000). Positive lymph node metastasis (p=0.044) and BCL10 LI>50% (p=0.037) were identified as independent unfavorable prognosis factors by multivariate analyses with Cox regression model. The Kaplan-Meier curve showed that OSCC patients with a BCL10 LI>50% had a significantly poorer cumulative survival than those with a BCL10 LI<50% (log-rank test, p<0.00001). We conclude that the BCL10 LI in OSCC samples can predict the progression of OSCCs and the survival of OSCC patients.
Chang
Hao-Hueng
HH
Graduate Institute of Clinical Dentistry, School of Dentistry, and Dental Department of National Taiwan University Hospital, College of Medicine, National Taiwan University, No. 1, Chang-Te Street, Taipei 10048, Taiwan.
Kuo
Mark Yen-Ping
MY
Cheng
Shih-Jung
SJ
Chiang
Chun-Pin
CP
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000074018:B-Cell CLL-Lymphoma 10 Protein; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology / Q000556:secondary; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology*; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D013624:Taiwan; D055815:Young Adult
D048868:Adaptor Proteins, Signal Transducing; D000074018:B-Cell CLL-Lymphoma 10 Protein; C118591:BCL10 protein, human; D014408:Biomarkers, Tumor