A fully continuous individual-based model of tumor cell evolution.
The aim of this work is to develop and study a fully continuous individual-based model (IBM) for cancer tumor invasion into a spatial environment of surrounding tissue. The IBM improves previous spatially discrete models, because it is continuous in all variables (including spatial variables), and thus not constrained to lattice frameworks. The IBM includes four types of individual elements: tumor cells, extracellular macromolecules (MM), a matrix degradative enzyme (MDE), and oxygen. The algorithm underlying the IBM is based on the dynamic interaction of these four elements in the spatial environment, with special consideration of mutation phenotypes. A set of stochastic differential equations is formulated to describe the evolution of the IBM in an equivalent way. The IBM is scaled up to a system of partial differential equations (PDE) representing the limiting behavior of the IBM as the number of cells and molecules approaches infinity. Both models (IBM and PDE) are numerically simulated with two kinds of initial conditions: homogeneous MM distribution and heterogeneous MM distribution. With both kinds of initial MM distributions spatial fingering patterns appear in the tumor growth. The output of both simulations is quite similar.
Gómez-Mourelo
Pablo
P
Dpto. Matemática Aplicada. ETSI Industriales (Universidad Politécnica de Madrid), c/ José Gutiérrez Abascal 2, Madrid, Spain. pablo.gomez.mourelo@upm.es
Sánchez
Eva
E
Casasús
Luis
L
Webb
Glenn F
GF
D000465:Algorithms; D002455:Cell Division; D003198:Computer Simulation; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D009154:Mutation; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000235:genetics / Q000473:pathology*; D011336:Probability