title: Luminal flow patterns dictate arterial drug deposition in stent-based delivery.
abstract: Endovascular stents reside in a dynamic flow environment and yet the impact of flow on arterial drug deposition after stent-based delivery is only now emerging. We employed computational fluid dynamic modeling tools to investigate the influence of luminal flow patterns on arterial drug deposition and distribution. Flow imposes recirculation zones distal and proximal to the stent strut that extend the coverage of tissue absorption of eluted drug and induce asymmetry in tissue drug distribution. Our analysis now explains how the disparity in sizes of the two recirculation zones and the asymmetry in drug distribution are determined by a complex interplay of local flow and strut geometry. When temporal periodicity was introduced as a model of pulsatile flow, the net luminal flow served as an index of flow-mediated spatio-temporal tissue drug uptake. Dynamically changing luminal flow patterns are intrinsic to the coronary arterial tree. Coronary drug-eluting stents should be appropriately considered where luminal flow, strut design and pulsatility have direct effects on tissue drug uptake after local delivery.
authors.affiliation: Biomedical Engineering Center, Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA. vbk@mit.edu
authors.forename: Vijaya B
authors.initials: VB
authors.lastname: Kolachalama
authors.forename: Abraham R
authors.initials: AR
authors.lastname: Tzafriri
authors.forename: Davis Y
authors.initials: DY
authors.lastname: Arifin
authors.forename: Elazer R
authors.initials: ER
authors.lastname: Edelman
mesh_terms: D000465:Algorithms; D019540:Area Under Curve; D001158:Arteries / Q000378:metabolism / Q000502:physiology; D001783:Blood Flow Velocity / Q000502:physiology; D001809:Blood Viscosity / Q000502:physiology; D003198:Computer Simulation; D023903:Coronary Restenosis / Q000188:drug therapy; D004058:Diffusion; D016503:Drug Delivery Systems / Q000379:methods; D054855:Drug-Eluting Stents; D018056:Hemorheology / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000378:metabolism*; D010599:Pharmacokinetics; D011673:Pulsatile Flow / Q000502:physiology
chemical_list: D004364:Pharmaceutical Preparations