Comparison of flame atomic absorption spectrometry (FAAS) and Cerimetric methods for the determination of ferrous sulfate content of some pharmaceutical products.
The iron content of ferrous sulphate syrup and tablet, ferroglobin, and Fefol were determined by both titration with cerium (Cerimetric method) proposed by united state pharmacopeias and flame atomic absorption spectrometry (FAAS). In FAAS both external calibration and standard addition method were used to evaluate the matrix effects. In the determination of iron content of ferrous sulphate tablet and syrup FAAS using external standard give approximately the same results as cerimetric methods of analysis. But in the case of ferroglobin syrup and Fefol capsule the external calibration results had large deviation from cerimetric method of analysis. So flame atomic absorption spectrometric involving standard addition is proposed for the analysis of iron content of these pharmaceutical products. The coefficient of variation for the FAAS determinations were in the range of 0.73-5.85 in one day and 2.39-7.51 between different days. Statistical evaluation showed good correlation between two methods.
Zahra
Ramezani
R
Ahvaz Jundi Shapour University of Medical Sciences, School of Pharmacy, Medicinal Chemistry Department, Ahvaz, Iran. zramezani@yahoo.com
Nadere
Rahbar
R
Azam
Ghanaatian
G
D002138:Calibration; D002214:Capsules; D002563:Cerium / Q000737:chemistry*; D005079:Excipients / Q000737:chemistry; D005296:Ferrous Compounds / Q000032:analysis*; D006397:Hematinics / Q000032:analysis*; D019999:Pharmaceutical Solutions; D013054:Spectrophotometry, Atomic / Q000592:standards; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods* / Q000592:standards; D017186:Titrimetry / Q000592:standards
D002214:Capsules; D005079:Excipients; D005296:Ferrous Compounds; D006397:Hematinics; D019999:Pharmaceutical Solutions; D013607:Tablets; D002563:Cerium; C020748:ferrous sulfate