Macelignan attenuates LPS-induced inflammation and reduces LPS-induced spatial learning impairments in rats.
Previous studies have shown that macelignan has anti-inflammatory and neuroprotective effects. Subsequently, in the current study, we demonstrate that oral administrations of macelignan reduce the hippocampal microglial activation induced by chronic infusions of lipopolysaccharide (LPS) into the fourth ventricle of Fisher-344 rat brains. A Morris water maze was used to evaluate the status of the hippocampal-dependent spatial learning in control rats with an artificial cerebrospinal fluid infusion, rats with chronic LPS infusions, and rats with chronic LPS infusions and oral administrations of macelignan. The rats with chronic LPS infusions showed spatial memory impairments relative to the control rats in the performance of the memory task. Daily administration of macelignan reduced the spatial memory impairments induced by the chronic LPS infusions. The results indicate that macelignan may possess therapeutic potential for the prevention of Alzheimer's disease.
Cui
Chun-Ai
CA
Department of Anatomy, Yanbian University School of Basic Medical Science, Yanbian 133-000, China.
Jin
Da-Qing
DQ
Hwang
Yoo Kyeong
YK
Lee
Im-Soon
IS
Hwang
Jae Kwan
JK
Ha
Ilho
I
Han
Jung-Soo
JS
D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D000949:Histocompatibility Antigens Class II / Q000378:metabolism; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D007859:Learning Disabilities / Q000139:chemically induced / Q000188:drug therapy*; D017705:Lignans / Q000627:therapeutic use*; D008070:Lipopolysaccharides; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D017628:Microglia / Q000187:drug effects; D051381:Rats; D011916:Rats, Inbred F344; D011930:Reaction Time / Q000187:drug effects; D013028:Space Perception / Q000187:drug effects*
D000949:Histocompatibility Antigens Class II; D017705:Lignans; D008070:Lipopolysaccharides; C502026:macelignan