title: Reliability of continuous cardiac output measurement during intra-abdominal hypertension relies on repeated calibrations: an experimental animal study.
abstract: BACKGROUND
  Monitoring cardiac output (CO) may allow early detection of haemodynamic instability, aiming to reduce morbidity and mortality in critically ill patients. Continuous cardiac output (CCO) monitoring is recommended in septic or postoperative patients with high incidences of intra-abdominal hypertension (IAH). The aim of the present study was to compare the agreement between three CCO methods and a bolus thermodilution CO technique during acute IAH and volume loading.
  
  
  METHODS
  Ten pigs were anaesthetised and instrumented for haemodynamic measurements. Cardiac output was obtained using CCO by pulse power analysis (PulseCO; LiDCO monitor), using CCO by pulse contour analysis (PCCO; PiCCO monitor) and using CCO by pulmonary artery catheter thermodilution (CCOPAC), and was compared with bolus transcardiopulmonary thermodilution CO (COTCP) at baseline, after fluid loading, at IAH and after an additional fluid loading at IAH. Whereas PulseCO was only calibrated at baseline, PCCO was calibrated at each experimental step.
  
  
  RESULTS
  PulseCO and PCCO underestimated CO, as the overall bias +/- standard deviation was 1.0 +/- 1.5 l/min and 1.0 +/- 1.1 l/min compared with COTCP. A clinically accepted agreement between all of the CCO methods and COTCP was observed only at baseline. Whereas IAH did not influence the CO, increased CO following fluid loading at IAH was only reflected by CCOPAC and COTCP, not by uncalibrated PulseCO and PCCO. After recalibration, PCCO was comparable with COTCP.
  
  
  CONCLUSIONS
  The CO obtained by uncalibrated PulseCO and PCCO failed to agree with COTCP during IAH and fluid loading. In the critically ill patient, recalibration of continuous arterial waveform CO methods should be performed after fluid loading or before a major change in therapy is initiated.
authors.affiliation: Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Schwanenweg 21, D-24105 Kiel, Germany. gruenewald@anaesthesie.uni-kiel.de
authors.forename: Matthias
authors.initials: M
authors.lastname: Gruenewald
authors.forename: Jochen
authors.initials: J
authors.lastname: Renner
authors.forename: Patrick
authors.initials: P
authors.lastname: Meybohm
authors.forename: Jan
authors.initials: J
authors.lastname: Höcker
authors.forename: Jens
authors.initials: J
authors.lastname: Scholz
authors.forename: Berthold
authors.initials: B
authors.lastname: Bein
mesh_terms: D034841:Abdominal Cavity / Q000503:physiopathology*; D000818:Animals; D002138:Calibration / Q000592:standards; D002302:Cardiac Output / Q000502:physiology*; D004195:Disease Models, Animal; D006973:Hypertension / Q000175:diagnosis / Q000503:physiopathology*; D008991:Monitoring, Physiologic / Q000379:methods / Q000592:standards; D015203:Reproducibility of Results; D012107:Research Design / Q000592:standards*; D034421:Sus scrofa