title: Mouse genetic models: an ideal system for understanding glaucomatous neurodegeneration and neuroprotection.
abstract: Here we review how mouse studies are contributing to understanding glaucoma. We include discussion of aqueous humor drainage and intraocular pressure elevation, because new treatments to avoid exposure to high pressure will indirectly protect neurons from glaucoma, and complement direct neuroprotective strategies. We describe how mouse models are adding to both the understanding of glaucomatous neurodegeneration and the development of neuroprotective strategies.
authors.affiliation: The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
authors.forename: Gareth R
authors.initials: GR
authors.lastname: Howell
authors.forename: Richard T
authors.initials: RT
authors.lastname: Libby
authors.forename: Simon W M
authors.initials: SW
authors.lastname: John
mesh_terms: D000818:Animals; D001082:Aqueous Humor; D004195:Disease Models, Animal; D005901:Glaucoma / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure; D051379:Mice; D008815:Mice, Inbred Strains; D008957:Models, Genetic; D009410:Nerve Degeneration / Q000473:pathology / Q000503:physiopathology; D018696:Neuroprotective Agents; D012165:Retinal Ganglion Cells / Q000166:cytology / Q000378:metabolism; D014065:Tonometry, Ocular / Q000379:methods; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D018696:Neuroprotective Agents; D014409:Tumor Necrosis Factor-alpha