title: Attenuation of morphine withdrawal signs by low level laser therapy in rats.
abstract: In the present study, the effects of low-intensity laser therapy (LILT) on naloxone-induced withdrawal signs of morphine-dependent rats were examined. Low-intensity lasers with a power density of 12.5J/cm(2) have been used by a Ga-Al-As laser. One-way ANOVA showed that the LILT which applied immediately or 15min prior to naloxone injection significantly decreased total withdrawal score (TWS). These results suggest that LILT prior to naloxone injection attenuates the expression of withdrawal signs in morphine-dependent rats. Further studies may elucidate the likely role of LILT in clinical management of opioid withdrawal syndrome.
authors.affiliation: Department of Physiology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran. emirzaii@razi.tums.ac.ir
authors.forename: Iraj
authors.initials: I
authors.lastname: Mirzaii-Dizgah
authors.forename: Reza
authors.initials: R
authors.lastname: Ojaghi
authors.forename: H R
authors.initials: HR
authors.lastname: Sadeghipour
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: Sadeghipour-Roodsari
authors.forename: Seyed Morteza
authors.initials: SM
authors.lastname: Karimian
authors.forename: Hamid
authors.initials: H
authors.lastname: Sohanaki
mesh_terms: D000701:Analgesics, Opioid; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003627:Data Interpretation, Statistical; D028022:Low-Level Light Therapy; D008297:Male; D009020:Morphine; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013375:Substance Withdrawal Syndrome / Q000628:therapy*
chemical_list: D000701:Analgesics, Opioid; D009292:Narcotic Antagonists; D009270:Naloxone; D009020:Morphine