Optimized elution of daptomycin from polymethylmethacrylate beads.
We demonstrate that xylitol can be added to polymethylmethacrylate (PMMA) bone cement to enhance the elution of daptomycin in terms of both the peak and sustained release of antibiotic. We also demonstrate that a PMMA-xylitol formulation optimized for daptomycin can be used to enhance the elution of both vancomycin and gentamicin.
Weiss
Brian D
BD
Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.
Weiss
Elizabeth C
EC
Haggard
Warren O
WO
Evans
Richard P
RP
McLaren
Sandra G
SG
Smeltzer
Mark S
MS
D001843:Bone Cements / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D017576:Daptomycin / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D004337:Drug Carriers / Q000737:chemistry; D005839:Gentamicins / Q000008:administration & dosage / Q000493:pharmacokinetics; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D014640:Vancomycin / Q000008:administration & dosage / Q000493:pharmacokinetics; D014993:Xylitol / Q000737:chemistry*
D001843:Bone Cements; D004337:Drug Carriers; D005839:Gentamicins; D014640:Vancomycin; D019904:Polymethyl Methacrylate; D017576:Daptomycin; D014993:Xylitol