Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1.
The synthesis and biological activities of imidazo[5,1-f][1,2,4]triazin-2-amines (imidazotriazines) as novel polo-like kinase 1 inhibitors are reported.
Cheung
M
M
GlaxoSmithKline, Fire Moore Drive, Research Triangle Park, NC 27709, USA. mui.h.cheung@gsk.com
Kuntz
K W
KW
Pobanz
M
M
Salovich
J M
JM
Wilson
B J
BJ
Andrews
C W
CW
Shewchuk
L M
LM
Epperly
A H
AH
Hassler
D F
DF
Leesnitzer
M A
MA
Smith
J L
JL
Smith
G K
GK
Lansing
T J
TJ
Mook
R A
RA
D000284:Administration, Oral; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D018797:Cell Cycle Proteins / Q000037:antagonists & inhibitors*; D020650:Combinatorial Chemistry Techniques; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors*; D011518:Proto-Oncogene Proteins / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D014227:Triazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000097869:Polo-Like Kinase 1
D000588:Amines; D000970:Antineoplastic Agents; D018797:Cell Cycle Proteins; D007093:Imidazoles; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D014227:Triazines; D000097869:Polo-Like Kinase 1