title: [Impact of negative lymph node number on prognosis advanced cancer of cardiac and stomach fundus].
abstract: OBJECTIVE
  To analyze the impact of negative lymph node number on the prognosis of advanced cancer of the cardia and stomach fundus.
  
  
  METHODS
  236 patients with advanced cancer of the cardia and stomach fundus underwent D2 radical resection. 5-year survival rate and recurrence rate were followed up and the relationships of lymph node (LN) number to 5-year survival rate and recurrence rate were analyzed respectively, according to LN count subgroups.
  
  
  RESULTS
  The 5-year survival rate of the entire cohort was 37.5%. The number of metastasis negative LNs was positively correlated with the LNs examined (P < 0.05). For the cancer at the same stage, the higher the number of metastasis negative LNs the higher the 5-year survival rate (P < 0.05). Linear correlation analysis showed that along with the increase of the number of negative LNs the post-operative survival rate increased. In the cancers at the stages III and IV, the 5-year survival rate increased by 6.09% and 7.65% respectively compared to the predicted values (P = 0.013 and P = 0.035). The overall recurrence rate was 61.0% within 5 years after surgery. For the cancers at the stages III and IV, the more the number of negative LNs the higher the 5-year survival rates (P < 0.05). In the cancers at the stages II and IV there were significant differences in the recurrence rates among the subgroups with different numbers of negative LNs (all P < 0.002).
  
  
  CONCLUSIONS
  Number of negative LNs has a close relation with stage-based survival prediction. Dissection of sufficient lymph nodes in the procedure of D2 dissection should be recommended so as to improve the long-term therapeutic effects and reduce the recurrence rate.
authors.affiliation: Department of Oncology, Union Hospital Affiliated to Fujian Medical University, Fuzhou 350001, China. hcmlr253@sohu.com
authors.forename: Chang-ming
authors.initials: CM
authors.lastname: Huang
authors.forename: Bi-juan
authors.initials: BJ
authors.lastname: Lin
authors.forename: Hui-shan
authors.initials: HS
authors.lastname: Lu
authors.forename: Xiang-fu
authors.initials: XF
authors.lastname: Zhang
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.forename: Jian-wei
authors.initials: JW
authors.lastname: Xie
mesh_terms: D000328:Adult; D000368:Aged; D002299:Cardia / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D005748:Gastric Fundus / Q000473:pathology*; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology* / Q000601:surgery; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000473:pathology*; D016019:Survival Analysis