title: Steroids linked with amide bond-extended cholesterol.
abstract: New type of linear cholesterol-like molecules based on cholesterol extended by attachment of etienic acid derivatives was designed and oligosteroids with two to four units were synthesized. Amide bond was used for inter steroid connections and 1-hydroxybenzotriazole active ester method was adapted for their formations. Use of disteroids as larger building blocks was applied.
authors.affiliation: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., 166 10 Prague 6, Czech Republic. cerny@ouchb.cas.cz
authors.forename: Ivan
authors.initials: I
authors.lastname: Cerný
authors.forename: Milos
authors.initials: M
authors.lastname: Budesínský
authors.forename: Vladimír
authors.initials: V
authors.lastname: Pouzar
authors.forename: Pavel
authors.initials: P
authors.lastname: Drasar
mesh_terms: D000577:Amides / Q000737:chemistry*; D000736:Androstenes / Q000737:chemistry*; D002784:Cholesterol / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000577:Amides; D000736:Androstenes; C004251:etienic acid; D002784:Cholesterol