Intravascular papillary endothelial hyperplasia: report of 2 cases and immunohistochemical study.
Intravascular papillary endothelial hyperplasia (IPEH) is a benign, nonneoplastic, vascular lesion. The main significance of the lesion lies in the fact that it may be mistaken for angiosarcoma. Oral lesions are uncommon and the present paper reports 2 cases of oral IPEH, in different sites. Histologically, the tissue was characterized by papillary fronds lined by proliferating endothelium. Immunohistochemically (IHC), the lesion was positive for CD34, smooth muscle actin (SMA), type I and IV collagen, vimentin, and laminin, but it was negative for CD105. Local excision was the treatment of choice. No recurrence was observed during a 1-year and 6-month follow-up period, respectively. The clinical, histological, and immunohistochemical characteristics are discussed.
Soares
Andresa Borges
AB
Department of Oral Pathology, São Leopoldo Mandic Research Center, Sao Paulo, Brazil. andresabs@hotmail.com
Altemani
Albina
A
Furuse
Cristiane
C
Demasi
Ana Paula Dias
AP
Gati
Carolina
C
Nunes
Nancy
N
de Araújo
Vera Cavalcanti
VC
D000199:Actins / Q000032:analysis; D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000032:analysis; D003937:Diagnosis, Differential; D004730:Endothelium, Vascular / Q000473:pathology*; D005260:Female; D024022:Fibrillar Collagens / Q000032:analysis; D006394:Hemangiosarcoma / Q000175:diagnosis; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D007150:Immunohistochemistry; D007797:Laminin / Q000032:analysis; D008047:Lip Diseases / Q000473:pathology; D009059:Mouth Diseases / Q000473:pathology*; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000175:diagnosis; D014652:Vascular Diseases / Q000473:pathology*; D014746:Vimentin / Q000032:analysis
D000199:Actins; D018952:Antigens, CD34; D024022:Fibrillar Collagens; D007797:Laminin; D014746:Vimentin