Quantification of cerebrospinal fluid ferritin as a biomarker for CNS malignant infiltration.
Several markers have been studied for their ability to make the CNS infiltration diagnosis earlier and more precise; previous studies showed that CSF ferritin concentrations were higher in patients with malignant invasion of CNS. The objective was to determine the importance of CSF ferritin as a biomarker for the diagnosis of CNS neoplastic infiltration. This study is based on 93 CSF samples, divided into five groups: malignant cells present (n13); malignant cells not present (n26); inflammatory neurological diseases (n16); neurocysticercosis (n20); acute bacterial meningitis (n18). CSF ferritin values were determined by micro particle enzyme immunoassay. CSF ferritin level (mean+/-SD) in the group with neoplastic cells in the CSF was 42.8+/-49.7 ng/mL, higher than in the other groups (p<0.0001). We conclude that CSF ferritin with the cut off 20 ng/mL could be an adjuvant biomarker to the diagnosis of CNS malignant infiltration.
Almeida
Sérgio Monteiro de
SM
Clinical Pathology Laboratory, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil. sergio.ma@pop.com.br
Cunha
Dione Sosnitzki da
DS
Yamada
Edna
E
Doi
Elvira Missako
EM
Ono
Margaret
M
D014408:Biomarkers, Tumor / Q000134:cerebrospinal fluid*; D016543:Central Nervous System Neoplasms / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D004797:Enzyme-Linked Immunosorbent Assay; D005293:Ferritins / Q000134:cerebrospinal fluid*; D006801:Humans; D012680:Sensitivity and Specificity
D014408:Biomarkers, Tumor; D005293:Ferritins