title: Genomic-scale prioritization of drug targets: the TDR Targets database.
abstract: The increasing availability of genomic data for pathogens that cause tropical diseases has created new opportunities for drug discovery and development. However, if the potential of such data is to be fully exploited, the data must be effectively integrated and be easy to interrogate. Here, we discuss the development of the TDR Targets database (http://tdrtargets.org), which encompasses extensive genetic, biochemical and pharmacological data related to tropical disease pathogens, as well as computationally predicted druggability for potential targets and compound desirability information. By allowing the integration and weighting of this information, this database aims to facilitate the identification and prioritization of candidate drug targets for pathogens.
authors.affiliation: Instituto de Investigaciones Biotecnológicas, Universidad Nacional de General San Martín, San Martín 1650, Buenos Aires, Argentina. fernan@unsam.edu.ar
authors.forename: Fernán
authors.initials: F
authors.lastname: Agüero
authors.forename: Bissan
authors.initials: B
authors.lastname: Al-Lazikani
authors.forename: Martin
authors.initials: M
authors.lastname: Aslett
authors.forename: Matthew
authors.initials: M
authors.lastname: Berriman
authors.forename: Frederick S
authors.initials: FS
authors.lastname: Buckner
authors.forename: Robert K
authors.initials: RK
authors.lastname: Campbell
authors.forename: Santiago
authors.initials: S
authors.lastname: Carmona
authors.forename: Ian M
authors.initials: IM
authors.lastname: Carruthers
authors.forename: A W Edith
authors.initials: AW
authors.lastname: Chan
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Crowther
authors.forename: Maria A
authors.initials: MA
authors.lastname: Doyle
authors.forename: Christiane
authors.initials: C
authors.lastname: Hertz-Fowler
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Hopkins
authors.forename: Gregg
authors.initials: G
authors.lastname: McAllister
authors.forename: Solomon
authors.initials: S
authors.lastname: Nwaka
authors.forename: John P
authors.initials: JP
authors.lastname: Overington
authors.forename: Arnab
authors.initials: A
authors.lastname: Pain
authors.forename: Gaia V
authors.initials: GV
authors.lastname: Paolini
authors.forename: Ursula
authors.initials: U
authors.lastname: Pieper
authors.forename: Stuart A
authors.initials: SA
authors.lastname: Ralph
authors.forename: Aaron
authors.initials: A
authors.lastname: Riechers
authors.forename: David S
authors.initials: DS
authors.lastname: Roos
authors.forename: Andrej
authors.initials: A
authors.lastname: Sali
authors.forename: Dhanasekaran
authors.initials: D
authors.lastname: Shanmugam
authors.forename: Takashi
authors.initials: T
authors.lastname: Suzuki
authors.forename: Wesley C
authors.initials: WC
authors.lastname: Van Voorhis
authors.forename: Christophe L M J
authors.initials: CL
authors.lastname: Verlinde
mesh_terms: D000818:Animals; D003141:Communicable Diseases / Q000188:drug therapy / Q000382:microbiology / Q000469:parasitology / Q000821:virology; D030541:Databases, Genetic; D015195:Drug Design; D016678:Genome; D006801:Humans