Association of obesity with inflammation in occult chronic kidney disease.
BACKGROUND
There are few studies concerning the development of chronic kidney disease (CKD) in obese patients independent of its relation with other risk factors. Also, the role of inflammation in this relationship is unclear. In this study we aimed to test the hypothesis that obesity is associated with risk for CKD and whether this risk is associated with serum C-reactive protein (CRP) levels in an apparently healthy obese population.


METHODS
Biochemical parameters and urinary protein excretion were determined in 110 patients with body mass index (BMI) >30.0 (calculated as kg/m2) and 50 age-matched healthy controls. Glomerular filtration rate was estimated by calculation of creatinine clearance.


RESULTS
Of the patients, 17.3% had CKD. They had higher CRP levels than controls (6.52 +/- 0.58 mg/L and 4.48 +/- 1.26 mg/L, respectively, p=0.001). Furthermore, CRP levels were positively correlated with BMI, waist circumference, waist to hip ratio and proteinuria, and negatively correlated with glomerular filtration rate (GFR). When GFR was considered as the dependent variable in a multiple regression analysis, CRP maintained its significant correlation with GFR.


CONCLUSIONS
Our study of apparently healthy obese individuals, has shown a significant association between BMI and CKD independent of other potential mediators. Furthermore, our findings suggest that inflammation may be the pathogenic mechanism of obesity-related CKD.
Bavbek
Nuket
N
Department of Nephrology, Fatih University Medical School, Ankara - Turkey. ntbavbek@yahoo.com
Isik
Bunyamin
B
Kargili
Ayse
A
Uz
Ebru
E
Uz
Burak
B
Kanbay
Mehmet
M
Turgut
Faruk
F
Karakurt
Feridun
F
Akcay
Ali
A
D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis*; D002908:Chronic Disease; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007249:Inflammation; D007674:Kidney Diseases / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D011507:Proteinuria
D002097:C-Reactive Protein