title: Prognostic value of electroencephalograms in asphyxiated newborns treated with hypothermia.
abstract: Previous studies described how early electroencephalogram patterns in neonatal hypoxic-ischemic encephalopathy seem to correlate with the severity of the clinical picture and provide prognostic information. This study evaluated whether electroencephalograms of newborns with severe perinatal hypoxic-ischemic encephalopathy, treated with hypothermia, provide information on clinical outcomes. Twenty-three newborns treated with hypothermia underwent electroencephalogram monitoring within 48 hours of age, and were enrolled in a follow-up with sequential electroencephalogram and neurologic controls (at ages 1 week, 1 month, 3-6 months, and 1 year). An inactive electroencephalogram pattern in the first 48 hours of age was associated with death or major neurologic sequelae. At age 1 week, a low-voltage, continuous pattern indicated a worse prognostic value when compared with other patterns. The persistence of electroencephalogram abnormalities at age 1 month was associated with a higher risk of neurologic sequelae. Background electroencephalogram abnormalities, detected in the first days of life after hypoxic-ischemic encephalopathy, can provide prognostic information, even in patients treated with hypothermia. After 1 month of age, the information on clinical outcomes provided by electroencephalograms usually decreases because of the natural trend toward electroencephalogram normalization.
authors.affiliation: Unit of Clinical Neurophysiology, Instituto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy.
authors.forename: Emilio
authors.initials: E
authors.lastname: Mariani
authors.forename: Barbara
authors.initials: B
authors.lastname: Scelsa
authors.forename: Laura
authors.initials: L
authors.lastname: Pogliani
authors.forename: Paola
authors.initials: P
authors.lastname: Introvini
authors.forename: Gianluca
authors.initials: G
authors.lastname: Lista
mesh_terms: D001238:Asphyxia Neonatorum / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy*; D004569:Electroencephalography; D005500:Follow-Up Studies; D006801:Humans; D007036:Hypothermia, Induced; D007231:Infant, Newborn; D015931:Intensive Care, Neonatal; D008991:Monitoring, Physiologic; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies