Functional biomimetic models for the active site in the respiratory enzyme cytochrome c oxidase.
A functional analog of the active site in the respiratory enzyme, cytochrome c oxidase (CcO) reproduces every feature in CcO's active site: a myoglobin-like heme (heme a3), a distal tridentate imidazole copper complex (Cu(B)), a phenol (Tyr244), and a proximal imidazole. When covalently attached to a liquid-crystalline SAM film on an Au electrode, this functional model continuously catalyzes the selective four-electron reduction of dioxygen at physiological potential and pH, under rate-limiting electron flux (as occurs in CcO).
Collman
James P
JP
Stanford University, Chemistry Department, Stanford, CA-94305-5080, USA. jpc@stanford.edu
Decréau
Richard A
RA
D032701:Biomimetics; D002384:Catalysis; D020134:Catalytic Domain; D004566:Electrodes; D004579:Electron Transport; D003576:Electron Transport Complex IV / Q000737:chemistry* / Q000378:metabolism; D008954:Models, Biological
D003576:Electron Transport Complex IV