The role of FXR in disorders of bile acid homeostasis.
As ligands for the nuclear receptor FXR, bile acids regulate their own synthesis, transport, and conjugation, thus protecting against bile acid toxicity. Recently, the role of genetic variants in FXR itself, FXR target genes, and regulators of FXR in the pathophysiology of the liver and intestine has become increasingly evident.
Eloranta
Jyrki J
JJ
Division of Clinical Pharmacology and Toxicology, University Hospital Zurich, Zurich, Switzerland. jyrki.eloranta@usz.ch
Kullak-Ublick
Gerd A
GA
D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism*; D001660:Biliary Tract Diseases / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology*; D004268:DNA-Binding Proteins / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D006706:Homeostasis / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007422:Intestines / Q000382:microbiology / Q000502:physiology; D008024:Ligands; D008107:Liver Diseases / Q000235:genetics / Q000503:physiopathology; D018160:Receptors, Cytoplasmic and Nuclear / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D014157:Transcription Factors / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D000099150:Receptor, Farnesoid X-Activated
D001647:Bile Acids and Salts; D004268:DNA-Binding Proteins; D008024:Ligands; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D000099150:Receptor, Farnesoid X-Activated