[A case of successful control for primary duodenal cancer with combined CPT-11, CDDP and DOC chemotherapy].
We have experienced a rare case of primary duodenal carcinoma with perforation of the duodenum. Combined CPT- 11, CDDP and DOC chemotherapy achieved a partial response. A 54-year-old man with serious abdominal pain visited our hospital with a diagnosis of acute peritonitis due to perforation of digestive tract on CT scan. An emergency operation was performed with patch for perforation of the duodenum. Endoscopic examination and biopsy after surgery showed duodenal adenocarcinoma. Abdominal CT scan revealed metastasis to the periaortic lymph nodes. Therefore, we diagnosed primary duodenal carcinoma with metastasis to the periaortic lymph nodes. Combined CPT-11, CDDP and DOC chemotherapy were performed. After two courses, endoscopic examination and biopsy showed primary lesion of the duodenum had disappeared. Metastatic lymph nodes were reduced from CT scan after three courses, and successfully controlled until nine courses. Then regimen was changed to S-1 alone and S-1/CPT-11. The patient remained alive for two years after the operation without tumor progression.
Satomi
Daisuke
D
Department of Surgery, National Hospital Organization Chiba Medical Center.
Morishima
Yuichi
Y
Suzuki
Ichirou
I
Aoki
Yasuo
Y
Tazawa
Youichi
Y
Kobayashi
Jun
J
Toyoda
Yasuyoshi
Y
Yoshida
Yukio
Y
Yamamoto
Kaisuke
K
Mori
Masahiro
M
Nakano
Masayuki
M
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002945:Cisplatin / Q000627:therapeutic use*; D000077143:Docetaxel; D004379:Duodenal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D004384:Duodenoscopy; D006801:Humans; D000077146:Irinotecan; D008297:Male; D008875:Middle Aged; D043823:Taxoids / Q000627:therapeutic use*; D013997:Time Factors; D014057:Tomography, X-Ray Computed
D043823:Taxoids; D000077143:Docetaxel; D000077146:Irinotecan; D002945:Cisplatin; D002166:Camptothecin