[The expression of tumor necrosis factor-related apoptosis inducing ligand and its receptors in muscle tissue of inflammatory myopathies].
OBJECTIVE
The purpose of this study is to analyse the expression of tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) and its receptors in muscle tissue from patients with idiopathic inflammatory myopathies ( IIM) and investigate the possible role of TRAIL system in the pathogenesis of IIM.


METHODS
TRAIL and its receptors DR4, DR5, DCR1 and DCR2 were detected in the muscle biopsy tissue from 36 patients with IIM (13 polymyositis, 23 dermatomyositis) and 9 healthy controls by using immunohistochemistry.


RESULTS
The expression of TRAIL and its receptors was found in muscle tissue samples from the IIM patients and healthy controls. The expression of TRAIL, DR4 and DCR2 in the muscle tissue from the IIM patients was significantly higher than those from healthy controls (all P values < 0.05). The expression of TRAIL, DCR1 and DR4 was also detected in the infiltrating lymphocytes in endomysium and in the interstitial tissue around blood vessels.


CONCLUSIONS
The diversity in expression of TRAIL and its receptors between patients with IIM and healthy controls suggests the hypothesis of a crucial role of TRAIL in the pathogenesis and the pathology of IIM.
Zhao
Hua
H
Department of Rheumatology, China-Japan Friendship Clinical Medicine College, Peking University, China-Japan Friendship Hospital, Beijing 100029, China.
Wang
Guo-Chun
GC
D000328:Adult; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism* / Q000473:pathology; D009220:Myositis / Q000378:metabolism* / Q000473:pathology; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand / Q000096:biosynthesis*; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000096:biosynthesis*
D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; D053221:TNF-Related Apoptosis-Inducing Ligand