Greater fat oxidation with diacylglycerol oil consumption for 14 days compared with triacylglycerol oil consumption in overweight men and women.
BACKGROUND
Several studies have reported increased fat oxidation with diacylglycerol (DAG) oil consumption. However, the effects of long-term DAG oil consumption on energy metabolism remain to be investigated.


OBJECTIVE
The objective of this study was to compare the effects of 14 days of either DAG or triacylglycerol (TAG) oil consumption on substrate oxidation, energy expenditure (EE) and dietary fat oxidation.


METHODS
Eight males and six females participated in this randomized, double-blind, crossover feeding study. Each patient consumed the 14-day controlled test diet containing either 10 g day(-1) of DAG or TAG oil for acclimatization before a respiratory chamber measurement, followed by a 2-week washout period between diet treatments. Substrate oxidation and EE were measured in the respiratory chamber at the end of each dietary treatment. The patients consumed test oil as 15% of total caloric intake in the respiratory chamber (mean test oil intake was 36.1+/-6.6 g day(-1)).


RESULTS
Twenty-four hour fat oxidation was significantly greater with 14 days of DAG oil consumption compared with TAG oil consumption (78.6+/-19.6 and 72.6+/-14.9 g day(-1), respectively, P<0.05). There were no differences in body weight or body composition between diet treatments. Dietary fat oxidation was determined using the recovery rate of (13)CO(2) in breath, and was significantly enhanced with DAG oil consumption compared with TAG oil consumption, measured over 22 h after ingestion of (13)C-labelled triolein. Resting metabolic rate (RMR) was significantly greater with DAG oil consumption compared with TAG oil consumption (1766+/-337 and 1680+/-316 kcal day(-1), respectively, P<0.05).


CONCLUSIONS
Consumption of DAG oil for 14 days stimulates both fat oxidation and RMR compared with TAG oil consumption, which may explain the greater loss of body weight and body fat with DAG oil consumption that has been observed in weight-loss studies.
Hibi
M
M
Health Care Food Research Laboratories, Kao Corporation, Sumida-ku, Tokyo, Japan. hibi.masanobu@kao.co.jp
Takase
H
H
Yasunaga
K
K
Yamaguchi
T
T
Shiiba
D
D
Saito
S
S
Yokoyama
R
R
Kudo
N
N
Katsuragi
Y
Y
Meguro
S
S
Shimizu
A
A
Tokimitsu
I
I
D000273:Adipose Tissue / Q000187:drug effects*; D000328:Adult; D001944:Breath Tests; D002245:Carbon Dioxide / Q000737:chemistry; D018592:Cross-Over Studies; D004041:Dietary Fats / Q000378:metabolism*; D004075:Diglycerides / Q000008:administration & dosage / Q000494:pharmacology*; D004311:Double-Blind Method; D004734:Energy Metabolism / Q000187:drug effects*; D005229:Fatty Acids, Monounsaturated; D005260:Female; D005502:Food; D006801:Humans; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000378:metabolism; D010084:Oxidation-Reduction; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology*; D000074262:Rapeseed Oil; D012450:Safflower Oil / Q000494:pharmacology; D013024:Soybean Oil / Q000494:pharmacology; D014041:Tokyo; D014280:Triglycerides / Q000008:administration & dosage / Q000494:pharmacology*; D017962:alpha-Linolenic Acid / Q000494:pharmacology
D004041:Dietary Fats; D004075:Diglycerides; D005229:Fatty Acids, Monounsaturated; D010938:Plant Oils; D000074262:Rapeseed Oil; D014280:Triglycerides; D017962:alpha-Linolenic Acid; D002245:Carbon Dioxide; C058216:perilla seed oil; D013024:Soybean Oil; D012450:Safflower Oil