title: Intermediacy and gene-environment interaction: the example of CHRNA5-A3 region, smoking, nicotine dependence, and lung cancer.
authors.forename: Sholom
authors.initials: S
authors.lastname: Wacholder
authors.forename: Nilanjan
authors.initials: N
authors.lastname: Chatterjee
authors.forename: Neil
authors.initials: N
authors.lastname: Caporaso
mesh_terms: D002884:Chromosomes, Human, Pair 15; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology* / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics*; D011978:Receptors, Nicotinic / Q000235:genetics*; D018570:Risk Assessment; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects* / Q000235:genetics*; D014029:Tobacco Use Disorder / Q000150:complications / Q000235:genetics*
chemical_list: C447158:CHRNA5 protein, human; D009419:Nerve Tissue Proteins; D011978:Receptors, Nicotinic