Myelin basic protein-specific T lymphocytes proliferation and programmed cell death in demyelinating diseases.
A dynamic equilibrium between proliferation and programmed cell death (PCD) of auto-reactive T lymphocytes plays a pivotal role in the prevention of autoimmune diseases. We analyzed T lymphocytes myelin basic protein (MBP)-specific PCD and proliferation in demyelinating diseases. Results showed that MBP-specific PCD was significantly decreased in CD4+ and CD8+ T lymphocytes of progressive multifocal leukoencephalopathy (PML), not determined leukoencephalopathy (NDLE), and acute MS (AMS) patients compared to patients with stable MS (SMS) and healthy controls. MBP-specific proliferation/PCD rates were high in CD4+ T lymphocytes of PML, NDLE, and AMS patients, and in CD8+ T cells of PML and AMS individuals alone. Alterations of the balance between MBP-specific proliferation and PCD are present in demyelinating diseases and could play a major role in the pathogenesis of these diseases.
Saresella
Marina
M
Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi Foundation ONLUS, IRCCS S. Maria Nascente, Via Capecelatro 66, 20148, Milan, Italy.
Marventano
Ivana
I
Guerini
Franca Rosa
FR
Zanzottera
Milena
M
Delbue
Serena
S
Marchioni
Enrico
E
Maserati
Renato
R
Longhi
Renato
R
Ferrante
Pasquale
P
Clerici
Mario
M
D000328:Adult; D000595:Amino Acid Sequence; D017209:Apoptosis / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D049109:Cell Proliferation; D016207:Cytokines / Q000276:immunology; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D003711:Demyelinating Diseases / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007577:JC Virus / Q000235:genetics / Q000276:immunology; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D004676:Myelin Basic Protein / Q000235:genetics / Q000276:immunology*; D010446:Peptide Fragments / Q000276:immunology; D016133:Polymerase Chain Reaction; D055815:Young Adult
D016207:Cytokines; D004279:DNA, Viral; D004676:Myelin Basic Protein; D010446:Peptide Fragments