title: Balkan endemic nephropathy: a still unsolved puzzle.
abstract: Balkan endemic nephropathy (BEN) is a chronic tubulointerstitial renal disease, occurring in certain regions in 5 countries of the Balkan peninsula. Its etiology is largely unknown, though several hypotheses have been formulated and are discussed in this review. In several cases, etiological hypotheses (e.g., viral, ochratoxin or trace element involvement) are verified only in local endemic areas and can not be confirmed when tested elsewhere. Only certain families in the endemic areas are affected. An exposure of at least 20 years to the unknown factors in the endemic areas seems to be mandatory for the development of the disease, but a genetic predisposition to this disease also seems to be mandatory. Prominent clinical features are severely shrunken kidneys, a more severe anemia relative to the level of renal function, and a slow progression to end-stage renal failure. An international approach to solving the etiological and pathogenetic enigma of BEN is needed in the coming years. It is also time to reevaluate other chronic, slowly progressive tubulointerstitial nephropathies diagnosed elsewhere in the world and to search for possible etiological similarities with BEN.
authors.affiliation: Nephrology Clinic, County Hospital and "Victor Babes" University of Medicine and Pharmacy, Timisoara - Romania.
authors.forename: Adalbert
authors.initials: A
authors.lastname: Schiller
authors.forename: Paul
authors.initials: P
authors.lastname: Gusbeth-Tatomir
authors.forename: Nikola
authors.initials: N
authors.lastname: Pavlovic
authors.forename: Dusan
authors.initials: D
authors.lastname: Ferluga
authors.forename: Goce
authors.initials: G
authors.lastname: Spasovski
authors.forename: Adrian
authors.initials: A
authors.lastname: Covic
mesh_terms: D001449:Balkan Nephropathy / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology