title: The first cyclic monomeric 3-alkylpyridinium alkaloid from natural sources: identification, synthesis, and biological activity.
abstract: 3-Alkylpyridine alkaloids are very common secondary metabolites from marine sponges of the order Haplosclerida. Here, we report on the identification and synthesis of the first cyclic monomeric 3-alkylpyridinium alkaloid from natural sources. Due to the lack of a pure sample of the new compound, structure elucidation had to rely on HPLC and MS(n).
authors.affiliation: Alfred-Wegener-Institut für Polar- und Meeresforschung in der Helmholtz-Gemeinschaft, Am Handelshafen 12, D-27570, Bremerhaven, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Timm
authors.forename: Christian
authors.initials: C
authors.lastname: Volk
authors.forename: Florenz
authors.initials: F
authors.lastname: Sasse
authors.forename: Matthias
authors.initials: M
authors.lastname: Köck
mesh_terms: D000470:Alkaloids / Q000737:chemistry*; D000818:Animals; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D047129:Haliclona / Q000737:chemistry*; D051379:Mice; D011726:Pyridinium Compounds / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000470:Alkaloids; D011726:Pyridinium Compounds