title: Lack of association of APOE and tau polymorphisms with dementia in Parkinson's disease.
abstract: Some APOE or tau gene polymorphisms have been associated with Alzheimer's disease (AD), progressive supranuclear palsy (PSP) and Parkinson's disease (PD). The reports of a possible association between the APOE 4 allele and dementia in PD are controversial, and some studies suggest that the tau H1/H1 genotype may increase the risk of dementia in PD. Here we analysed these APOE and tau polymorphisms in 86 clinically diagnosed PD patients with dementia (PDD), in 138 clinically diagnosed non-demented PD (PDND) patients, and in 91 healthy controls. Genomic DNA isolated from blood was used for PCR and subsequent RFLP analysis. We examined the possible genetic association of these polymorphisms with dementia in PD, but found no differences in genotypic distributions between the PDND, PDD, and control groups. The effects of tau and APOE polymorphisms on the age at dementia onset were studied using Kaplan-Meier survival analysis but no significant association were found. The lack of association between the APOE 4 allele and PDD suggests that the pathological process involved in the development of dementia in PD is different from the one that occurs in AD.
authors.affiliation: Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clínic de Barcelona, Department of Medicine, Universitat de Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain.
authors.forename: Mario
authors.initials: M
authors.lastname: Ezquerra
authors.forename: Jaume
authors.initials: J
authors.lastname: Campdelacreu
authors.forename: Carles
authors.initials: C
authors.lastname: Gaig
authors.forename: Yaroslau
authors.initials: Y
authors.lastname: Compta
authors.forename: Esteban
authors.initials: E
authors.lastname: Muñoz
authors.forename: Maria Jose
authors.initials: MJ
authors.lastname: Martí
authors.forename: Francesc
authors.initials: F
authors.lastname: Valldeoriola
authors.forename: Eduardo
authors.initials: E
authors.lastname: Tolosa
mesh_terms: D000368:Aged; D001057:Apolipoproteins E / Q000235:genetics*; D004252:DNA Mutational Analysis; D003704:Dementia / Q000150:complications / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000235:genetics*; D011110:Polymorphism, Genetic; D012189:Retrospective Studies; D016875:tau Proteins / Q000235:genetics*
chemical_list: D001057:Apolipoproteins E; D016875:tau Proteins