title: Smooth-muscle myosin mutations in hereditary non-polyposis colorectal cancer syndrome.
abstract: We examined adenomas and cancers from hereditary non-polyposis colorectal cancer (HNPCC) syndrome patients for the presence of frameshift mutations in the smooth-muscle myosin gene, MYH11. Our results show that mutations in MYH11 occur more frequently in cancers than adenomas (P=0.008) and are dependent on microsatellite instability (MSI+).
authors.affiliation: Colorectal Cancer Genetics, Institute for Cell and Molecular Sciences, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Whitechapel, London, UK.
authors.forename: N
authors.initials: N
authors.lastname: Vickaryous
authors.forename: G
authors.initials: G
authors.lastname: Polanco-Echeverry
authors.forename: S
authors.initials: S
authors.lastname: Morrow
authors.forename: N
authors.initials: N
authors.lastname: Suraweera
authors.forename: H
authors.initials: H
authors.lastname: Thomas
authors.forename: I
authors.initials: I
authors.lastname: Tomlinson
authors.forename: A
authors.initials: A
authors.lastname: Silver
mesh_terms: D000236:Adenoma / Q000235:genetics; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics*; D016368:Frameshift Mutation; D006801:Humans; D053842:Microsatellite Instability; D018995:Myosin Heavy Chains / Q000235:genetics*; D024745:Smooth Muscle Myosins / Q000235:genetics*
chemical_list: C509903:MYH11 protein, human; D024745:Smooth Muscle Myosins; D018995:Myosin Heavy Chains