CSF neurofilament and soluble TNF receptor 1 levels in subacute sclerosing panencephalitis.
Neurofilament (NF) is one of the major cytoskeleton proteins of neurons and sTNFR1 is thought to reflect the true biological activity of TNF-alpha. To evaluate the levels of the heavy subunit of neurofilament (NF-H) and soluble TNF receptor 1 (sTNFR1) in cerebrospinal fluid (CSF) as biomarkers of clinical severity of subacute sclerosing panencephalitis (SSPE), concentrations of NF-H and sTNFR1 in CSF of 34 patients with SSPE and in control subjects were measured by ELISA. The CSF NF-H levels were significantly higher in patients with SSPE than in controls (p<0.0001), and those in patients in Jabbour stage III were significantly higher than in patients in stage II (p=0.015). The CSF sTNFR1 levels in SSPE patients were significantly higher than those in controls (p=0.004), but there were no significant differences in CSF sTNFR1 levels between patients in Jabbour stages II and III. There was a significant correlation between CSF NF-H and sTNFR1 levels in patients with SSPE (p=0.011). We suggest that CSF NF-H levels can be used as a marker of development of neuronal degeneration in SSPE, and that TNF-alpha modifies the neurodestructive pathogenesis in SSPE.
Matsushige
Takeshi
T
Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan.
Ichiyama
Takashi
T
Anlar
Banu
B
Tohyama
Jun
J
Nomura
Keiko
K
Yamashita
Yushiro
Y
Furukawa
Susumu
S
D000293:Adolescent; D015415:Biomarkers / Q000134:cerebrospinal fluid; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D000068800:Etanercept; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D016900:Neurofilament Proteins / Q000134:cerebrospinal fluid*; D018124:Receptors, Tumor Necrosis Factor; D018709:Statistics, Nonparametric; D013344:Subacute Sclerosing Panencephalitis / Q000134:cerebrospinal fluid* / Q000473:pathology; D055815:Young Adult
D015415:Biomarkers; D007074:Immunoglobulin G; D016900:Neurofilament Proteins; D018124:Receptors, Tumor Necrosis Factor; C051774:neurofilament protein H; D000068800:Etanercept