title: Chemotherapy consisting of paclitaxel and carboplatin benefits a patient with malignant mixed müllerian tumor of the fallopian tube.
abstract: Malignant mixed müllerian tumors (MMMT) of the fallopian tube are extremely rare, and optimal therapy for them is unknown. A 71-year-old woman presented to us with symptoms of abdominal distension and nausea. A right salpingo-oophorectomy was performed. Pathological examination determined International Federation of Gynecology and Obstetrics (FIGO) stage IIIc MMMT of the right fallopian tube. Of note, multiple tumoral nodules were attached to the sigmoid colon. The patient received three courses of chemotherapy, consisting of 175 mg/m(2) paclitaxel and AUC=5 carboplatin (TC therapy), administered at 3-week intervals. A second, debulking, surgery was then performed, consisting of total abdominal hysterectomy, left salpingo-oophorectomy, and pelvic and paraaortic lymphadenectomy. The tumor attached to the sigmoid colon had shrunk by 60% after chemotherapy. The patient received an additional five courses of adjuvant TC therapy. The patient is alive and free of disease 28 months after the debulking surgery. TC therapy may be effective for MMMT of the fallopian tube.
authors.affiliation: Department of Obstetrics and Gynecology, Tottori University School of Medicine, 36-1 Nishicho, Yonago 683-8504, Japan.
authors.forename: Wakae
authors.initials: W
authors.lastname: Kawaguchi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Itamochi
authors.forename: Junzo
authors.initials: J
authors.lastname: Kigawa
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Kanamori
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Oishi
authors.forename: Muneaki
authors.initials: M
authors.lastname: Shimada
authors.forename: Shinya
authors.initials: S
authors.lastname: Sato
authors.forename: Seiya
authors.initials: S
authors.lastname: Sato
authors.forename: Naoki
authors.initials: N
authors.lastname: Terakawa
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005185:Fallopian Tube Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D018200:Mixed Tumor, Mullerian / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D010052:Ovariectomy; D017239:Paclitaxel / Q000008:administration & dosage*
chemical_list: D016190:Carboplatin; D017239:Paclitaxel