title: Estimated glomerular filtration rate for drug dose adjustment: Cockcroft and Gault or abbreviated MDRD equation?
abstract: OBJECTIVE
  Evaluate if Cockcroft and Gault (CG) estimated glomerular filtration rate (eGFR) might be replaced by abbreviated MDRD eGFR for drug dose adjustment.
  
  
  METHODS
  eGFR was determined in 140 hospitalized patients (median: 68 years, 65 kg) treated by nephrotoxic and/or renally cleared drugs.
  
  
  RESULTS
  CG eGFR was 61 mL/min vs. 78 mL/min/1.73 m(2) for MDRD (p<0.0001). CG-MDRD difference ranged from -93 to +34 mL/min, influenced by patient age, weight, and gender (p<0.001).
  
  
  CONCLUSIONS
  CG eGFR cannot be easily replaced by abbreviated MDRD eGFR for drug dose adjustment.
authors.affiliation: Pharmacy Department, Valence Hospital, 26000 Valence, France. iroblin@ch-valence.fr
authors.forename: Isabelle
authors.initials: I
authors.lastname: Roblin
authors.forename: Sophie
authors.initials: S
authors.lastname: De Sobarnitsky
authors.forename: Cécile
authors.initials: C
authors.lastname: Basselin
authors.forename: Fabienne
authors.initials: F
authors.lastname: Vial
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Bard
authors.forename: Isabelle
authors.initials: I
authors.lastname: Dufrene
authors.forename: Hassan
authors.initials: H
authors.lastname: Hida
authors.forename: Christian
authors.initials: C
authors.lastname: Laurencin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D008875:Middle Aged
chemical_list: D003404:Creatinine