Coordinated protein sorting, targeting and distribution in polarized cells.
The polarized distribution of functions in polarized cells requires the coordinated interaction of three machineries that modify the basic mechanisms of intracellular protein trafficking and distribution. First, intrinsic protein-sorting signals and cellular decoding machineries regulate protein trafficking to plasma membrane domains; second, intracellular signalling complexes define the plasma membrane domains to which proteins are delivered; and third, proteins that are involved in cell-cell and cell-substrate adhesion orientate the three-dimensional distribution of intracellular signalling complexes and, accordingly, the direction of membrane traffic. The integration of these mechanisms into a complex and dynamic network is crucial for normal tissue function and is often defective in disease states.
Mellman
Ira
I
Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA. mellman.ira@gene.com
Nelson
W James
WJ
D000818:Animals; D002462:Cell Membrane / Q000737:chemistry; D016764:Cell Polarity; D003599:Cytoskeleton / Q000378:metabolism; D006801:Humans; D038081:Organogenesis; D010336:Pathology; D021381:Protein Transport; D011506:Proteins / Q000032:analysis / Q000378:metabolism
D011506:Proteins