title: Identifying fallers with Parkinson's disease using home-based tests: who is at risk?
abstract: The objective of this work is to determine risk factors for falling in patients with Parkinson's disease (PD) using home-based assessments and develop a prediction model. Data on falls, balance, gait-related activities, and nonmotor symptoms were obtained from 153 PD patients (Hoehn-Yahr 2-4) in their home. Fifty-one candidate determinants for falling were independently tested using bivariate logistic regression analysis. A multivariate logistic regression model was developed to identify patients susceptible to falls. Sixty-six subjects (43%) were classified as fallers. Eighteen determinants for falling were selected. The final multivariate model showed an accuracy of 74% and included: (1) Freezing of Gait Questionnaire, (2) Timed Get Up and Go (TGUG) score, (3) disease duration, (4) item 15 of the Unified Parkinson's Disease Rating Scale. Based on disease duration, freezing symptoms, walking problems, and a prolonged TGUG duration, assessed in the home situation, it was possible to accurately identify 74% of PD patients as fallers.
authors.affiliation: Department of Rehabilitation Medicine, Research Institute MOVE, VU University Medical Center, Amsterdam, The Netherlands. i.lim@vumc.nl
authors.forename: Inge
authors.initials: I
authors.lastname: Lim
authors.forename: Erwin
authors.initials: E
authors.lastname: van Wegen
authors.forename: Diana
authors.initials: D
authors.lastname: Jones
authors.forename: Lynn
authors.initials: L
authors.lastname: Rochester
authors.forename: Alice
authors.initials: A
authors.lastname: Nieuwboer
authors.forename: Anne Marie
authors.initials: AM
authors.lastname: Willems
authors.forename: Katherine
authors.initials: K
authors.lastname: Baker
authors.forename: Vicki
authors.initials: V
authors.lastname: Hetherington
authors.forename: Gert
authors.initials: G
authors.lastname: Kwakkel
mesh_terms: D000058:Accidental Falls; D000203:Activities of Daily Living; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D020233:Gait Disorders, Neurologic / Q000209:etiology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009460:Neurologic Examination; D010300:Parkinson Disease / Q000503:physiopathology*; D012306:Risk; D055815:Young Adult