[Cardiac troponins and left ventricular hypertrophy in hemodialysis patients].
BACKGROUND
Cardiovascular diseases are the most frequent cause of death among hemodialysis patients. Left ventricular hypertrophy is a potent predictor of cardiovascular morbidity and mortality in those patients. Cardiac troponins (cTnT and cTnI) are indices of myocardial cell damage. The study was aimed to investigate the impact of left ventricular hypertrophy on serum cardiac troponin concentrations.


METHODS
The study included 115 patients (71 men and 44 women) at the mean age of 53.30+/-12.17 years, treated with regular hemodialyses for 4.51+/-4.01 years, with mean left ventricle mass index LVMi 143.85+/-41.21 g/m2 and mean Kt/Vsp 1.17+/-0.23. According to echocardiographic findings of the left ventricle the patients were divided into four groups: the first group included patients with concentric left ventricular hypertrophy, the second group were the patients with eccentric left ventricular hypertrophy, the third group consisted of patients with left ventricular dilatation, and the fourth group were patients with normal left ventricular morphology. The mean serum troponin T value in the first group was 0.13+/-0.16 ng/ml, in the second group 0.20+/-0.32 ng/ml, in the third group 0.07+/-0.09, and in the fourth group 0.03+/-0.03 ng/ml.


RESULTS
Patients with concentric left ventricular hypertrophy showed significantly greater (p<0.05) and patients with eccentric left ventricular hypertrophy showed highly significantly greater (p<0.01) serum troponin T concentrations in comparasion to patients with normal left ventricular morphology.


CONCLUSIONS
Serum cardiac troponin T concentration can also be used to estimate left ventricular hypertrophy in clinically stable patients on hemodialysis, in the absence of acute coronary syndrome.
Petrović
Dejan
D
Klinika za urologiju i nefrologiju, Odeljenje hemodijalize, Klinicki centar Kragujevac, Kragujevac. aca96@Eunet.yu
Obrenović
Radmila
R
Radovanović
Milan
M
Stojimirović
Biljana
B
D004452:Echocardiography; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood* / Q000000981:diagnostic imaging / Q000209:etiology; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D020107:Troponin T / Q000097:blood*
D020107:Troponin T