Gold nanoparticles functionalised by Gd-complex of DTPA-bis(amide) conjugate of glutathione as an MRI contrast agent.
The work is directed toward the synthesis of gold nanoparticles (Au NPs) coated with paramagnetic Gd-complex of DTPA-bis(amide) conjugate of glutathione (GdL) for use as a highly efficient MRI contrast agent. Well-dispersed spherical Au NPs coated with gadolinium complexes, abbreviated as Au@GdL, have been obtained; the mean size of Au@GdL is 5-7 nm, and the numbers of GdL are 1.36x10(4) per Au NP. Au@GdL exhibits high longitudinal (r1) and transverse (r2) relaxivities of 1.87x10(5) and 3.02x10(5) mM(-1) s(-1), respectively.
Park
Ji-Ae
JA
Department of Medical & Biological Engineering, Kyungpook National University, Daegu, Republic of Korea.
Reddy
Pattubala A N
PA
Kim
Hee-Kyung
HK
Kim
In-Sung
IS
Kim
Gab-Chul
GC
Chang
Yongmin
Y
Kim
Tae-Jeong
TJ
D003287:Contrast Media / Q000737:chemistry*; D019786:Gadolinium DTPA / Q000031:analogs & derivatives* / Q000737:chemistry; D005978:Glutathione; D006046:Gold / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D053758:Nanoparticles; D009942:Organometallic Compounds / Q000737:chemistry*
D003287:Contrast Media; D009942:Organometallic Compounds; D006046:Gold; D005978:Glutathione; D019786:Gadolinium DTPA