[Interoceptive and exteroceptive cues in the tolerance of the ethanol ataxic effect in rats].
In the current analysis of classic conditioning with regard to the phenomenon of drug tolerance, there is empirical evidence of interoceptive pharmacologic cues and of exteroceptive cues, which are associated with the effect of the drug. The former could overshadow the latter. The aim of the present investigation was to contribute experimental data about the interaction that occurs between these two kinds of cues. For this purpose, a set of interoceptive and exteroceptive cues was presented as conditioned stimulus, together with an unconditioned stimulus that corresponded to the ataxic effects of ethanol. The results showed that the interoceptive cues were associated with the ataxic effect of ethanol, and they produced a tolerance response of the same intensity as the exteroceptive cues.
Betancourt Mainhard
Ronald
R
Universidad de Chile, Santiago, Chile.
Díaz Dosque
Carmen Gloria
CG
Quezada Scholz
Vanetza
V
D000818:Animals; D001259:Ataxia / Q000139:chemically induced*; D002492:Central Nervous System Depressants / Q000009:adverse effects*; D004361:Drug Tolerance; D000431:Ethanol / Q000009:adverse effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D002492:Central Nervous System Depressants; D000431:Ethanol