title: Cortical plasticity following nerve transfer in the upper extremity.
abstract: With increasing clinical experience, peripheral nerve surgeons have come to appreciate the important role that cortical plasticity and motor relearning play in functional recovery following a nerve transfer. Neurostimulation (transcranial magnetic stimulation), and neuroimaging (functional MRI, structural MRI, magnetoencephalography) measure different aspects of cortical physiology and when used together are powerful tools in the study of cortical plasticity. The mechanisms of cortical plasticity, according to current and widely accepted opinions, involve the unmasking of previously ineffective connections or the sprouting of intact afferents from adjacent cortical or subcortical territories. Although significant strides have been made in our understanding of cortical plasticity following nerve transfer and during motor relearning, a great deal remains that we do not understand. Cortical plasticity and its manipulation may one day become important contributors to improve functional outcome following nerve transfer.
authors.affiliation: Division of Plastic Surgery, University of Toronto, 399 Bathurst Street, East Wing -2, Toronto, Ontario Canada M5G 2S8. dimitri.anastakis@uhn.on.ca
authors.forename: Dimitri J
authors.initials: DJ
authors.lastname: Anastakis
authors.forename: Martijn J A
authors.initials: MJ
authors.lastname: Malessy
authors.forename: Robert
authors.initials: R
authors.lastname: Chen
authors.forename: Karen D
authors.initials: KD
authors.lastname: Davis
authors.forename: David
authors.initials: D
authors.lastname: Mikulis
mesh_terms: D000671:Amputation, Surgical; D002540:Cerebral Cortex / Q000502:physiology*; D006801:Humans; D007858:Learning / Q000502:physiology; D008279:Magnetic Resonance Imaging; D009048:Motor Skills / Q000502:physiology; D016067:Nerve Transfer; D009473:Neuronal Plasticity / Q000502:physiology*; D059348:Peripheral Nerve Injuries; D010525:Peripheral Nerves / Q000503:physiopathology / Q000601:surgery*; D050781:Transcranial Magnetic Stimulation; D034941:Upper Extremity / Q000293:injuries / Q000294:innervation* / Q000503:physiopathology / Q000601:surgery