title: [Expression and significance of glypican-3 in colorectal cancer].
abstract: OBJECTIVE
  To investigate the expression and significance of Glypican-3 in colorectal cancer.
  
  
  METHODS
  Immunohistochemistry was used to detect the expression of Glypican-3 in 200 specimens of colorectal cancer and adjacent non-cancerous tissues resected during operation.
  
  
  RESULTS
  Glypican-3 immunoreactivity was recognized in both the cytoplasm and cellular membrane. The Glypican-3 positive expression rate in the tumor samples was 66.0% (132/200), significantly higher than that in the adjacent nontumor tissues (24%, 48/200, P = 0.019). The Glypican-3 expression rate was significantly correlated with the carcinoma invasion (P = 0.023) and lymph node metastasis (P = 0.015), but not associated with gender, age, tumor size, and differentiation grade (all P > 0.05).
  
  
  CONCLUSIONS
  Over-expression of Glypican-3 may play an important role in the genesis and development of colorectal cancer, and may be used as a new biological parameter in predicting invasion and metastasis of colorectal carcinoma.
authors.affiliation: Institute of Gastroenterology, Xijing Hospital of Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Dong-Hong
authors.initials: DH
authors.lastname: Yuan
authors.forename: Hua-Hong
authors.initials: HH
authors.lastname: Xie
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Cun-Ying
authors.initials: CY
authors.lastname: Meng
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Yang
authors.forename: Yi-Chao
authors.initials: YC
authors.lastname: Feng
authors.forename: Jiu-Gang
authors.initials: JG
authors.lastname: Song
authors.forename: Xue
authors.initials: X
authors.lastname: Zou
authors.forename: Kai-Chun
authors.initials: KC
authors.lastname: Wu
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
mesh_terms: D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D053673:Glypicans / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness
chemical_list: D053673:Glypicans