title: Natural history of cervical intraepithelial neoplasia during pregnancy.
abstract: OBJECTIVE
  It is uncertain whether pregnancy influences the natural history of cervical intraepithelial neoplasia (CIN). Our aim was to evaluate the evolution of CIN in pregnant women.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Department of Obstetrics and Gynaecology, University of Insubria, Italy.
  
  
  METHODS
  Women with histological CIN during pregnancy.
  
  
  METHODS
  Between 2003 and 2007, women with an abnormal Pap-smear during pregnancy underwent colposcopy. Patients with histological CIN were followed during pregnancy with colposcopy every 8 weeks and post-partum evaluation was scheduled 3-6 months after delivery. Women with post-partum histological diagnosis of CIN 2-3 underwent conization. To understand the impact of pregnancy on the evolution of CIN, women with CIN 1 discovered during pregnancy were compared to a group of non-pregnant fertile patients with first diagnosis of CIN 1.
  
  
  RESULTS
  A total of 78 women were included: 36 (46.2%) with CIN 2-3 and 42 (53.8%) with CIN 1. In women with CIN 2-3, no invasion was suspected during pregnancy and at post-partum evaluation, no invasive or microinvasive cancer, and 19 (52.7%) persistent CIN 2-3, and 17 (47.3%) regressions were diagnosed. In the group of CIN 1, we recorded six (14.3%) progressions to CIN 2-3, seven (16.6%) persistent CIN 1 and 29 (69%) regressions. The control group of non-pregnant women had a lower regression rate (37/76: 48.7%) in comparison to pregnant women (p=0.03).
  
  
  CONCLUSIONS
  Expectant management for CIN 2-3 diagnosed during gestation is safe. When discovered during pregnancy, CIN 1 has a significantly higher tendency to spontaneous regression in comparison to non-pregnant condition.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Insubria, Varese, Italy. mauserati@hotmail.com
authors.forename: Maurizio
authors.initials: M
authors.lastname: Serati
authors.forename: Stefano
authors.initials: S
authors.lastname: Uccella
authors.forename: Rosa M
authors.initials: RM
authors.lastname: Laterza
authors.forename: Stefano
authors.initials: S
authors.lastname: Salvatore
authors.forename: Paolo
authors.initials: P
authors.lastname: Beretta
authors.forename: Cristina
authors.initials: C
authors.lastname: Riva
authors.forename: Pier Francesco
authors.initials: PF
authors.lastname: Bolis
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003075:Coitus; D018450:Disease Progression; D005260:Female; D006801:Humans; D010298:Parity; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology / Q000503:physiopathology*; D011446:Prospective Studies; D012907:Smoking; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000503:physiopathology*; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000473:pathology / Q000503:physiopathology*