MLXIPL variant in individuals with low and high triglyceridemia in white population in Central Europe.
We tested the hypothesis that the MLXIPL rs3812316 variant predicts plasma triglyceride (TG) levels. We compared three groups of adult individuals: 162 persons with TG > 10 mmol/L, 266 persons with TG < 0.65 mmol/L, and 2,043 population-based controls (range of TG concentrations 0.7-8.7 mmol/L). We found a small difference in the frequency of the Gln allele carriers between population controls (20.4%) and persons with low TG (26.3%, P = 0.033). We found no difference between individuals with high TG and population controls, and there was no association between the MLXIPL variant and plasma TG levels among the population controls.
Vrablik
Michal
M
3rd Internal Department, 1st Medical Faculty, Charles University, Prague, Czech Republic.
Ceska
Richard
R
Adamkova
Vera
V
Peasey
Anne
A
Pikhart
Hynek
H
Kubinova
Ruzena
R
Marmot
Michael
M
Bobak
Martin
M
Hubacek
Jaroslav A
JA
D000328:Adult; D000368:Aged; D019943:Amino Acid Substitution; D001483:Base Sequence; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000235:genetics*; D016022:Case-Control Studies; D018153:Czech Republic; D004247:DNA / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014280:Triglycerides / Q000097:blood*; D044465:White People / Q000235:genetics
D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; C116385:MLXIPL protein, human; D014280:Triglycerides; D004247:DNA