title: Comparison of vanadium-rich activity of three species fungi of basidiomycetes.
abstract: A comparison of vanadium-rich activity of three species fungi of Basidiomycetes, Ganoderma lucidum, Coprinus comatus, and Grifola frondosa, was studied. By fermentation and atomic absorption spectroscopy analysis, the biomass of G. lucidum and G. frondosa declined rapidly when the concentration of vanadium exceeded 0.3% but the biomass of C. comatus did not decline rapidly until the concentration of vanadium exceeded 0.4% and the content of vanadium accumulated in the mycelia was 3529.3 microg/g. After the mice were administered (intragastrically) with vanadium-rich C. comatus, the blood glucose of alloxan-induced hyperglycemic mice was decreased (p < 0.05) and the body weight of the alloxan-induced hyperglycemic mice was increased gradually. Thus, we selected C. comatus to absorb vanadium and chose 0.4% as the optimal concentration of vanadium for the pharmacological works.
authors.affiliation: School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, People's Republic of China. sdscipaper@126.com
authors.forename: Chunchao
authors.initials: C
authors.lastname: Han
authors.forename: Bo
authors.initials: B
authors.lastname: Cui
authors.forename: Jingran
authors.initials: J
authors.lastname: Qu
mesh_terms: D000818:Animals; D001487:Basidiomycota / Q000187:drug effects* / Q000378:metabolism; D003302:Coprinus / Q000187:drug effects / Q000378:metabolism; D048691:Grifola / Q000187:drug effects / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D051379:Mice; D008820:Mice, Obese; D020940:Reishi / Q000187:drug effects / Q000378:metabolism; D014639:Vanadium / Q000494:pharmacology*
chemical_list: D007004:Hypoglycemic Agents; D014639:Vanadium