title: Pathogenic effector T cell enrichment overcomes regulatory T cell control and generates autoimmune gastritis.
abstract: Regulatory T cells (Treg) deficiency leads to a severe, systemic, and lethal disease, as showed in immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome patients, and scurfy mouse. Postneonatal thymectomy autoimmune gastritis has also been attributed to the absence of Tregs. In this case however, disease is mild, organ-specific, and, more important, it is not an obligatory outcome. We addressed this paradox comparing T cell compartments in gastritis-susceptible and resistant animals. We found that neonatal thymectomy-induced gastritis is not caused by the absence of Tregs. Instead of this, it is the presence of gastritogenic T cell clones that determines susceptibility to disease. The expansion of such clones under lymphopenic conditions results in a reduced Treg:effector T cell ratio that is not enough to control gastritis development. Finally, the presence of gastritogenic clones is determined by the amount of gastric Ag expressed in the neonatal thymus, emphasizing the importance of effector repertoire variability, present even in genetically identical subjects, to organ-specific autoimmune disease susceptibility.
authors.affiliation: Divisão de Medicina Experimental, Coordenação de Pesquisa, Instituto Nacional de Câncer, Rio de Janeiro, Brazil.
authors.forename: João P
authors.initials: JP
authors.lastname: Monteiro
authors.forename: Julia
authors.initials: J
authors.lastname: Farache
authors.forename: Ana Carolina
authors.initials: AC
authors.lastname: Mercadante
authors.forename: Julio A
authors.initials: JA
authors.lastname: Mignaco
authors.forename: Martin
authors.initials: M
authors.lastname: Bonamino
authors.forename: Adriana
authors.initials: A
authors.lastname: Bonomo
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology*; D005756:Gastritis / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control; D020022:Genetic Predisposition to Disease; D007113:Immunity, Innate / Q000235:genetics; D008231:Lymphopenia / Q000235:genetics / Q000276:immunology / Q000473:pathology; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008819:Mice, Nude; D016513:Mice, SCID; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000276:immunology* / Q000473:pathology*