title: Larger regional white matter volume is associated with executive function deficit in remitted geriatric depression: an optimized voxel-based morphometry study.
abstract: OBJECTIVE
  We aimed to investigate structural abnormalities in first-episode remitted geriatric depression (RGD) using optimized voxel-based morphometry (VBM) in closely matched patients and healthy controls, and examining the relationship of performances on neuropsychological tests with regional white matter volumes.
  
  
  METHODS
  Forty subjects with first-episode RGD and 36 well-matched healthy controls were recruited for this study and neuropsychological tests and magnetic resonance imaging (MRI) were conducted on the subjects. The differences in regional white matter volume were determined between these two groups by optimized VBM.
  
  
  RESULTS
  The white matter volumes of left inferior parietal lobule and right inferior frontal gyrus were significantly larger in patients with RGD relative to healthy controls. RGD patients performed significantly worse in the delayed recall of RAVLT, Trail Making Test A and B (seconds), and Symbol Digit Modalities Test when compared with the control group (all P<0.01). And there was a significant positive correlation between white matter volume of right inferior frontal gyrus and Trail Making Test A (r=0.319, P=0.045) in patients with RGD.
  
  
  CONCLUSIONS
  This study is cross-sectional, therefore it cannot determine whether increased white matter volume is a state marker or trait marker of RGD.
  
  
  CONCLUSIONS
  These results reveal that RGD is associated with larger white matter volumes of left inferior parietal lobule and right inferior frontal gyrus, and the right inferior frontal gyrus may thus be involved in the pathophysiology of executive function in RGD.
authors.affiliation: School of Clinical Medicine, Southeast University, Nanjing 210009, PR China.
authors.forename: Yonggui
authors.initials: Y
authors.lastname: Yuan
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Zhang
authors.forename: Feng
authors.initials: F
authors.lastname: Bai
authors.forename: Hui
authors.initials: H
authors.lastname: Yu
authors.forename: Jiayong
authors.initials: J
authors.lastname: You
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Shi
authors.forename: Yun
authors.initials: Y
authors.lastname: Qian
authors.forename: Wen
authors.initials: W
authors.lastname: Liu
authors.forename: Tianzi
authors.initials: T
authors.lastname: Jiang
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000473:pathology* / Q000523:psychology; D003866:Depressive Disorder / Q000175:diagnosis / Q000523:psychology*; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D009929:Organ Size; D010296:Parietal Lobe / Q000473:pathology; D011594:Psychometrics; D012016:Reference Values