title: Immunoglobulin expression and its biological significance in cancer cells.
abstract: It is generally believed that the expression of a gene is restricted "within the right place and at the right time". This principle has long been considered applicable as well to the expression of immunoglobulin (Ig) lymphocytes of B cell lineage. However, increasing evidence has shown Ig "paradoxically" expressed in malignant tumors of epithelial origin. We reviewed the recent progress in the study of cancer-derived Ig, and also discussed its mechanisms and possible functions, trying to arouse interest and attention to those working in the field of immunology and oncology.
authors.affiliation: Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
authors.forename: Duosha
authors.initials: D
authors.lastname: Hu
authors.forename: Hui
authors.initials: H
authors.lastname: Zheng
authors.forename: Haidan
authors.initials: H
authors.lastname: Liu
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Ren
authors.forename: Wei
authors.initials: W
authors.lastname: Liao
authors.forename: Zhi
authors.initials: Z
authors.lastname: Duan
authors.forename: Lili
authors.initials: L
authors.lastname: Li
authors.forename: Ya
authors.initials: Y
authors.lastname: Cao
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D019070:Cell Lineage / Q000276:immunology; D022801:Complementarity Determining Regions; D006801:Humans; D017578:Immunoglobulin Class Switching; D007136:Immunoglobulins / Q000096:biosynthesis / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology* / Q000378:metabolism; D050441:VDJ Exons
chemical_list: D022801:Complementarity Determining Regions; D007136:Immunoglobulins