Human mitochondrial variants influence on oxygen consumption.
This work investigates if human mitochondrial variants influence on maximal oxygen consumption (VO(2max)). With this purpose we recruited, as a uniform population in term of nutritional habits and life style, 114 healthy male Spanish subjects that practiced fitness exercises 3-4 times a week. Once mtDNA haplogroups were determined, we found that J presents with lower VO(2max) (P=0.02) than nonJ variants. J has been related with a lower efficiency of electron transport chain (ETC), diminished ATP and ROS production. Thus, the difficult to compensate the mitochondrial energetic deficiency could explain the accumulation of J haplogroup in LHON and multiple sclerosis. Furthermore, the lower ROS production associated to J could also account for the accrual of this variant in elderly people consequent to a decreased oxidative damage.
Marcuello
Ana
A
Departmento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, Miguel Servet 177, 50013 Zaragoza, Spain.
Martínez-Redondo
Diana
D
Dahmani
Yahya
Y
Casajús
José A
JA
Ruiz-Pesini
Eduardo
E
Montoya
Julio
J
López-Pérez
Manuel J
MJ
Díez-Sánchez
Carmen
C
D000255:Adenosine Triphosphate / Q000378:metabolism; D000328:Adult; D004247:DNA / Q000378:metabolism; D004272:DNA, Mitochondrial / Q000378:metabolism; D004579:Electron Transport; D015444:Exercise; D005080:Exercise Test; D006239:Haplotypes; D006801:Humans; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D008931:Mitochondria, Muscle / Q000378:metabolism; D018384:Oxidative Stress; D010101:Oxygen Consumption
D004272:DNA, Mitochondrial; D000255:Adenosine Triphosphate; D004247:DNA