title: Histological evaluation of Curcuma longa-ghee formulation and hyaluronic acid on gingival healing in dog.
abstract: BACKGROUND
  The experimental finding of Asian traditional medicine revealed the pharmacological effect of the local application of ghee which was taken from cow butterfat and the rhizomes of Curcuma longa. These materials significantly improved the healing process of the wound. In addition, ancient physicians of Middle East discovered that the powdered rhizomes of Curcuma longa (common turmeric) also had impressive medicinal qualities. Over the centuries, this spice has been used as a pain relieving, anti-inflammatory agent to relieve pain and inflammation in the skin and muscles.
  
  
  OBJECTIVE
  We decided to mix ghee which was taken from sheep butterfat with the powdered rhizomes of Curcuma longa to formulate a novel cost-benefit material and then, evaluate its potential therapeutic effect on acceleration of surgical wound healing; moreover, this present study was performed to compare the effects of Curcuma longa-ghee formulation and hyaluronic acid on gingival wound healing following surgery.
  
  
  METHODS
  Five healthy 3-year-old male beagle dogs were used in this study. They had intact teeth and the clinical and radiographic examination revealed no periodontal disease. Ghee was obtained from the refined sheep butterfat heated to 70 degrees C mixed with the powdered rhizomes of Curcuma longa and was applied with two different ratios including materials A and B. Randomly, these three materials including hyaluronic acid, materials A and B were applied topically in test regions and then covered with periodontal pack. Histological changes were monitored in days 4 and 7 after operation to evaluate the inflammatory and repair stage of healing process.
  
  
  RESULTS
  We observed significant difference in the inflammatory and repair parameters of the healing process between cases treated with this new formulation and cases of hyaluronic acid application.
  
  
  CONCLUSIONS
  The results suggested a positive potential therapeutic effect on surgical wound healing particularly improvement of periodontal treatment consequences after surgery.
authors.affiliation: Department of Periodontics, School of Dentistry and Dental Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Ghanbari
authors.initials: G
authors.lastname: Habiboallah
authors.forename: Saghravanian
authors.initials: S
authors.lastname: Nasroallah
authors.forename: Zakery
authors.initials: Z
authors.lastname: Mahdi
authors.forename: Mahdavi Shahri
authors.initials: MS
authors.lastname: Nasser
authors.forename: Zakery
authors.initials: Z
authors.lastname: Massoud
authors.forename: Baradaran Nasseri
authors.initials: BN
authors.lastname: Ehsan
authors.forename: Zareian Jahromi
authors.initials: ZJ
authors.lastname: Mina
authors.forename: Parsaei
authors.initials: P
authors.lastname: Heidar
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D003362:Cost-Benefit Analysis; D030024:Curcuma / Q000737:chemistry*; D004041:Dietary Fats / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004285:Dogs; D005881:Gingiva / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D005890:Gingivectomy; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007249:Inflammation / Q000188:drug therapy / Q000209:etiology; D008297:Male; D008519:Medicine, Traditional; D008517:Phytotherapy / Q000191:economics / Q000379:methods*; D011897:Random Allocation; D027343:Rhizome / Q000737:chemistry; D012756:Sheep; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000188:drug therapy / Q000473:pathology
chemical_list: D000276:Adjuvants, Immunologic; D004041:Dietary Fats; D006820:Hyaluronic Acid