[Inhibition of permeability transition and myocardic reperfusion damage by cyclosporine A].
BACKGROUND
The results presented in this study indicate that the immunosuppressor cyclosporine A acts as a cardioprotective drug.


METHODS
This effect was analyzed during development of reperfusion-induced arrhythmias after 5 min period of coronary ligation in hearts of rats under anesthesia.


RESULTS
The results indicate that cyclosporine inhibits Ca(2+)-induced mitochondrial damage; furthermore, when given before coronary occlusion, at a dose of 20 mg/kg, effectively protects against the high incidence of arrhythmias and the fall in blood pressure induced by reperfusion. In addition, it inhibits the delivery of lactic dehydrogenase and creatine kinase enzymes to the plasma.


CONCLUSIONS
We propose that the protective effect could be related with its well documented action to restrain Ca(2+)-induced damage of mitochondrial functions.
Chávez
Edmundo
E
Departamento de Bioquímica, Instituto Nacional de Cardiología "Ignacio Chávez", INCICH, Juan Badiano Núm. 1, Col. Sección XVI, Tlalpan 14080, México, DF.
García
Noemí
N
Pavón
Natalia
N
D000818:Animals; D016572:Cyclosporine / Q000494:pharmacology / Q000627:therapeutic use*; D007166:Immunosuppressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D010539:Permeability / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
D007166:Immunosuppressive Agents; D016572:Cyclosporine