title: [A case of multiple liver metastases of sigmoid colon cancer responding well to UFT+Leucovorin therapy].
abstract: The subject was a 75-year-old female. For the treatment of multiple liver metastases from sigmoid colon cancer, the administration of UFT(300 mg/day)and oral Leucovorin(75 mg/day)was initiated after a resection of the sigmoid colon. A decrease in the liver metastases was observed in a CT scan 4 months after the start of this administration, and the disappearance of the metastatic focus in the liver was confirmed at 10 months thereafter. The administration of UFT and oral Leucovorin was continued for 2 months. Thereafter, at 12 months after the start of this administration, was continued with only the administration of UFT(300 mg/day)for 1 year. Now, 26 months have passed since the liver metastases disappeared and no recurrence has been found, even within the abdominal cavity. The condition of the patient has been excellent. The subject of this study was an elderly person, but an excellent QOL was secured without any adverse events, and the chemotherapy regimen could be maintained for 2 years. These findings suggest that UFT and oral Leucovorin can be expected to have an excellent therapeutic effect as an oral chemotherapeutic agent.
authors.affiliation: Department of Surgery, St. Marianna University Yokohama City Seibu Hospital.
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Ishii
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Komoriyama
authors.forename: Shinya
authors.initials: S
authors.lastname: Mikami
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Ashikawa
authors.forename: Takehito
authors.initials: T
authors.lastname: Ohtsubo
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary*; D008279:Magnetic Resonance Imaging; D011859:Radiography; D012811:Sigmoid Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D005641:Tegafur / Q000627:therapeutic use; D014463:Ultrasonography; D014498:Uracil / Q000627:therapeutic use
chemical_list: D005641:Tegafur; D014498:Uracil; D002955:Leucovorin