title: Synthesis of 6-O-methotrexylhyaluronan as a drug delivery system.
abstract: Selective halogenation of hyaluronan and partial halogen substitution by methotrexate led to 6-chloro-6-deoxy-6-O-methotrexylhyaluronan, a potential antitumor drug. The remaining halogen could be further substituted by a second organic carboxylate, leading to mixed esters. 6-O-Acetyl-6-O-methotrexylhyaluronan and 6-O-butyryl-6-O-methotrexylhyaluronan were thus synthesized and characterized by NMR spectroscopy.
authors.affiliation: Eurand S.p.A., Area Science Park, Padriciano 99, 34012 Trieste, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Sorbi
authors.forename: Massimo
authors.initials: M
authors.lastname: Bergamin
authors.forename: Susanna
authors.initials: S
authors.lastname: Bosi
authors.forename: Francesca
authors.initials: F
authors.lastname: Dinon
authors.forename: Vincent
authors.initials: V
authors.lastname: Aroulmoji
authors.forename: Riaz
authors.initials: R
authors.lastname: Khan
authors.forename: Erminio
authors.initials: E
authors.lastname: Murano
authors.forename: Stefano
authors.initials: S
authors.lastname: Norbedo
mesh_terms: D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry*; D006820:Hyaluronic Acid / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008727:Methotrexate / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D004337:Drug Carriers; D006820:Hyaluronic Acid; D008727:Methotrexate