title: [Pituitary necrosis and antiphospholipid syndrome].
abstract: Antiphospholipid syndrome (APS) is an acquired thrombotic disorder. It mainly occurs with systemic disease or as a primary disorder. All organs may be involved by thrombosis, but to date the most common endocrine manifestation is chronic adrenal insufficiency. Very few cases of hypopituitarism with primary APS have been reported. We report the case of a 27-year-old woman, victim of a stroke leading to double vision and intracranial hypertension. Magnetic resonance imaging showed a macro-adenoma with hemorrhage of a suprasellar lesion. Hormone assessment showed hyper prolactinemia with positive anticardiolipin antibody. Our case is the second reported associating APS with apoplexy. We discuss the clinical, biological and radiological features observed in our case. We conclude that APS should be searched for whenever a history of adenoma with apoplexy is found associated with recurrent thrombosis.
authors.affiliation: Service de médecine interne et d'endocrinologie, CHU Monastir, 5000 Monastir, Tunisie. ineskhoc@yahoo.fr
authors.forename: I
authors.initials: I
authors.lastname: Khochtali
authors.forename: M
authors.initials: M
authors.lastname: Kacem
authors.forename: S
authors.initials: S
authors.lastname: Kria
authors.forename: M
authors.initials: M
authors.lastname: Golli
authors.forename: S
authors.initials: S
authors.lastname: Mahjoub
mesh_terms: D000236:Adenoma / Q000150:complications / Q000473:pathology; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000473:pathology / Q000628:therapy; D005260:Female; D006728:Hormones / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D006966:Hyperprolactinemia / Q000097:blood / Q000209:etiology; D007018:Hypopituitarism / Q000150:complications* / Q000473:pathology / Q000628:therapy; D019586:Intracranial Hypertension / Q000150:complications; D008279:Magnetic Resonance Imaging; D009336:Necrosis; D019635:Neurosurgical Procedures; D010902:Pituitary Gland / Q000473:pathology; D010911:Pituitary Neoplasms / Q000150:complications / Q000473:pathology; D020521:Stroke / Q000209:etiology
chemical_list: D000893:Anti-Inflammatory Agents; D006728:Hormones; D006854:Hydrocortisone