title: Tailoring beta-cyclodextrin for DNA complexation and delivery by homogeneous functionalization at the secondary face.
abstract: An efficient general strategy for the incorporation of functional elements onto the secondary hydroxyl rim of beta-cyclodextrin has been developed and applied to the synthesis of a novel series of C7-symmetric homogeneous macromolecular polycations with improved DNA complexing and delivery properties.
authors.affiliation: Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Sevilla, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Ortega-Caballero
authors.forename: Carmen Ortiz
authors.initials: CO
authors.lastname: Mellet
authors.forename: Loïc
authors.initials: L
authors.lastname: Le Gourriérec
authors.forename: Nicolas
authors.initials: N
authors.lastname: Guilloteau
authors.forename: Christophe
authors.initials: C
authors.lastname: Di Giorgio
authors.forename: Pierre
authors.initials: P
authors.lastname: Vierling
authors.forename: Jacques
authors.initials: J
authors.lastname: Defaye
authors.forename: José M
authors.initials: JM
authors.lastname: García Fernández
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000378:metabolism*; D051379:Mice; D014162:Transfection; D047392:beta-Cyclodextrins / Q000138:chemical synthesis* / Q000378:metabolism* / Q000633:toxicity
chemical_list: D047392:beta-Cyclodextrins; D004247:DNA; C031215:betadex