[Inherited thrombophilia in women with recurrent miscarriages and pregnancy loss in anamnesis--own experience].
Single nucleotide polymorphisms of the genes coding for coagulation factors are the cause of congenital thrombophilia which might lead to recurrent miscarriages and fetal loss in advanced pregnancy. The most frequent reasons of thrombophilia are the following: factor V Leiden (1691G>A), mutation 20210G>A of prothrombin gene, and 677C>T of 5, 10-methylenetetrahydrofoliate reductase gene. The following article briefly summarizes the administration of antithrombotic prophylaxis (low-molecular weight heparin, acetylsalicylic acid) which seems to be an effective course of action to prevent complications in next pregnancies. What is more, adverse events after long-term usage of low-molecular weight heparin and acetylsalicylic acid in prophylactic doses have not been observed. Due to lack of complete randomized investigation about the inclusion of antithrombotic prophylaxis in this group of pregnant women, common scheme of administration and optimal dosage is yet to be established.
Seremak-Mrozikiewicz
Agnieszka
A
Klinika Perinatologii i Chorób Kobiecych Uniwersytetu Medycznego w Poznaniu. asm@data.pl
Drews
Krzysztof
K
Puacz
Piotr
P
Kaluba-Skotarczak
Agnieszka
A
D000026:Abortion, Habitual / Q000175:diagnosis* / Q000188:drug therapy* / Q000235:genetics; D000328:Adult; D001241:Aspirin / Q000008:administration & dosage; D005165:Factor V / Q000235:genetics; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011516:Prothrombin / Q000235:genetics; D019851:Thrombophilia / Q000175:diagnosis* / Q000188:drug therapy* / Q000235:genetics; D016896:Treatment Outcome
D005343:Fibrinolytic Agents; D006495:Heparin, Low-Molecular-Weight; C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; D001241:Aspirin