Schwann cell to axon transfer of ribosomes: toward a novel understanding of the role of glia in the nervous system.
Schwann cells play pivotal roles in the development and maintenance of the peripheral nervous system. Here, we show that intact sciatic nerve axons of mice contain a small population of ribosomes, which increases by several orders of magnitude when axons are desomatized (severed from their cell bodies). We furthermore demonstrate, using the Wallerian degeneration slow mouse as a model, that Schwann cells transfer polyribosomes to desomatized axons. These data indicate that Schwann cells have the propensity to control axonal protein synthesis by supplying ribosomes on local basis.
Court
Felipe A
FA
Departamento de Fisiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica, 114-D Santiago, Chile.
Hendriks
William T J
WT
MacGillavry
Harold D
HD
Alvarez
Jaime
J
van Minnen
Jan
J
D000818:Animals; D001369:Axons / Q000502:physiology* / Q000648:ultrastructure; D001692:Biological Transport / Q000235:genetics; D004195:Disease Models, Animal; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D046529:Microscopy, Electron, Transmission / Q000379:methods; D004676:Myelin Basic Protein / Q000378:metabolism; D018993:Myelin P0 Protein / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000235:genetics; D009457:Neuroglia / Q000166:cytology* / Q000502:physiology; D011132:Polyribosomes / Q000378:metabolism; D012270:Ribosomes / Q000378:metabolism*; D012583:Schwann Cells / Q000502:physiology*; D020426:Sciatic Neuropathy / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D014162:Transfection / Q000379:methods
D004676:Myelin Basic Protein; D018993:Myelin P0 Protein; D009419:Nerve Tissue Proteins; C442580:Wld protein, mouse; C485184:enhanced green fluorescent protein; D049452:Green Fluorescent Proteins