The persistency of high levels of pSTAT3 expression in circulating CD4+ T cells from CIS patients favors the early conversion to clinically defined multiple sclerosis.
Not all patients with clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS) develop clinically defined MS (CDMS). At first clinical event we observed increased production of IL17, IFNgamma and IL10 by peripheral blood mononuclear cells from patients with CIS that remained high in remission. In CD4+ T cells pSTAT3 expression was higher in patients who subsequently converted to CDMS than in patients who did not and controls. The persistency of high levels of pSTAT3 in circulating CD4+ T cells from CIS patients after the first clinical event may favor the early conversion to CDMS.
Frisullo
Giovanni
G
Institute of Neurology, Department of Neuroscience, Catholic University, Rome, Italy.
Nociti
Viviana
V
Iorio
Raffaele
R
Patanella
Agata Katia
AK
Marti
Alessandro
A
Mirabella
Massimiliano
M
Tonali
Pietro Attilio
PA
Batocchi
Anna Paola
AP
D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism*; D016022:Case-Control Studies; D016207:Cytokines / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000097:blood* / Q000276:immunology*; D050796:STAT3 Transcription Factor / Q000378:metabolism*; D055815:Young Adult
D016207:Cytokines; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human