title: Choriocarcinoma with pulmonary and cerebral metastases.
abstract: Choriocarcinoma is an aggressive tumour. Uncommonly, it spreads distantly, and rarely results in pulmonary and brain metastases. Its prognosis is generally good when treated. We report a 33-year-old woman with fever, haemoptysis and asthenia. One month after the appearance of metrorrhagia, she was diagnosed to have choriocarcinoma with pulmonary metastasis. After chemotherapy, pulmonary images disappeared and human chorionic gonadotropin returned to normal. She was re-admitted with neurological signs ten months later, confirming recurrence of the disease with brain metastasis. She was treated with surgery and polychemotherapy, with a favourable outcome and disappearance of the disease.
authors.affiliation: Department of Internal Medicine, Hospital Clínico Universitario "Lozano Blesa", Avda San Juan Bosco 15, Zaragoza 50009, Spain.
authors.forename: B
authors.initials: B
authors.lastname: Sierra-Bergua
authors.forename: M
authors.initials: M
authors.lastname: Sánchez-Marteles
authors.forename: J L
authors.initials: JL
authors.lastname: Cabrerizo-García
authors.forename: I
authors.initials: I
authors.lastname: Sanjoaquin-Conde
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001247:Asthenia / Q000209:etiology; D001932:Brain Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy*; D002822:Choriocarcinoma / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D006063:Chorionic Gonadotropin / Q000378:metabolism; D005260:Female; D031901:Gestational Trophoblastic Disease / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D006469:Hemoptysis / Q000209:etiology; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy*; D009362:Neoplasm Metastasis; D011247:Pregnancy; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy
chemical_list: D006063:Chorionic Gonadotropin