title: A touch screen based Stop Signal Response Task in rhesus monkeys for studying impulsivity associated with chronic cocaine self-administration.
abstract: Among a range of cognitive deficits, human cocaine addicts display increased impulsivity and decreased performance monitoring. In order to establish an animal model that can be used to study the underlying neurobiology of these deficits associated with addiction, we have developed a touch screen based Stop Signal Response Task for rhesus monkeys. This task is essentially identical to the clinically used Stop Signal Task employed for diagnostic and research purposes. In this task, impulsivity is reflected in the amount of time needed to inhibit a response after it has been initiated, the Stop Signal Response Time (SSRT). Performance monitoring is reflected by the slowing of response times following Stop trials (Post-Stop Slowing, PSS). Herein we report on the task structure, the staged methods for training animals to perform the task, and a comparison of performance values for control and cocaine experienced animals. Relative to controls, monkeys that had self-administered cocaine, followed by 18 months abstinence, displayed increased impulsivity (increased SSRT values), and decreased performance monitoring (decreased PSS values). Our results are consistent with human data, and thereby establish an ideal animal model for studying the etiology and underlying neurobiology of cocaine-induced impulse control and performance monitoring deficits.
authors.affiliation: Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Shijing
authors.initials: S
authors.lastname: Liu
authors.forename: Richard P
authors.initials: RP
authors.lastname: Heitz
authors.forename: Charles W
authors.initials: CW
authors.lastname: Bradberry
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002755:Choice Behavior / Q000502:physiology; D003042:Cocaine / Q000008:administration & dosage*; D018765:Dopamine Uptake Inhibitors / Q000008:administration & dosage*; D005260:Female; D007175:Impulsive Behavior / Q000503:physiopathology* / Q000523:psychology*; D007266:Inhibition, Psychological; D008253:Macaca mulatta; D008297:Male; D009048:Motor Skills; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012646:Self Administration / Q000379:methods; D013647:Task Performance and Analysis; D014110:Touch / Q000187:drug effects
chemical_list: D018765:Dopamine Uptake Inhibitors; D003042:Cocaine