title: Clinical experience with a new endoscopic over-the-scope clip system for use in the GI tract.
abstract: BACKGROUND
  The newly designed over-the-scope clip (OTSC) seems to overcome several limitations of current clipping system, such as size and opening-closing force, allowing better control of gastric or colonic bleeding and/or deep wall defect or perforation.
  
  
  OBJECTIVE
  The aim of this retrospective analysis was to describe the new endoscopic device and evaluate our first clinical experience.
  
  
  METHODS
  We treated with the OTSC system 9 patients (range, 58-85 years; 6 men, 3 women) with bleeding and/or deep wall lesions of the GI tract. The OTSC system is composed of an application cap, which is mounted onto the distal tip of the endoscope and a connected releasing mechanism, installed on the handle of the scope. The rotation of the handle allows the release of the clip by a two tube sliding mechanism.
  
  
  RESULTS
  All applications resulted successful, i.e. haemostasis was achieved, and/or wall defects could be closed. No complication was observed that could be ascribed to the clip itself or to the technique.
  
  
  CONCLUSIONS
  The OTSC system is a new endoscopic tool for compression of large tissue areas and its indications are nonvaricose bleedings difficult to control and lesions or perforations of the GI tract. The initial clinical use of this clipping device proved to be efficient and effective.
authors.affiliation: Department of Gastroenterology and Digestive Endoscopy Unit, IRCCS Istituto Clinico Humanitas, Milan, Italy. alessandro.repici@humanitas.it
authors.forename: A
authors.initials: A
authors.lastname: Repici
authors.forename: A
authors.initials: A
authors.lastname: Arezzo
authors.forename: G
authors.initials: G
authors.lastname: De Caro
authors.forename: M
authors.initials: M
authors.lastname: Morino
authors.forename: N
authors.initials: N
authors.lastname: Pagano
authors.forename: G
authors.initials: G
authors.lastname: Rando
authors.forename: F
authors.initials: F
authors.lastname: Romeo
authors.forename: G
authors.initials: G
authors.lastname: Del Conte
authors.forename: S
authors.initials: S
authors.lastname: Danese
authors.forename: A
authors.initials: A
authors.lastname: Malesci
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019723:Endoscopes; D016145:Endoscopy, Digestive System / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods*; D004867:Equipment Design; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007416:Intestinal Perforation / Q000209:etiology / Q000517:prevention & control; D007417:Intestinal Polyps / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013525:Surgical Instruments; D016896:Treatment Outcome