title: The lipidome as a composite biomarker of the modifiable part of the risk of breast cancer.
abstract: The potential for dietary fat to prevent breast cancer makes identification of defined molecules a mandatory step. In order to circumvent the limitations and/or bias of dietary exposure assessment tools, we have used the fatty acid composition of white adipose tissue as biomarker of past lipid intake. When considered separately, candidate fatty acids identified as favourable on the basis of their association with breast cancer risk have usually led to inconsistent results in dietary intervention studies carried out in rats. This inconsistency indicates that any approach based on a single fatty acid should be abandoned for an integrated view over the complex lipid interactions, which finally determines the lipidome, the lipid profile that is found in individuals. We reappraised the role of the complete lipid profile through a comprehensive study of adipose tissue fatty acids obtained in patients with benign or malignant breast tumors. Rather than a single fatty acid, a composite indicator combining elevated monounsaturates and low n-6/n-3 fatty acid ratio was associated with decreased breast cancer risk. The lipidome may provide the opportunity to quantify the modifiable part of the risk of breast cancer. The lipidome may be used as a template for designing proper dietary modifications in order to delay the occurrence of breast cancer. Which dietary modifications should be undertaken in order to bring a pertinent change to the lipidome with respect to the risk of breast cancer is currently unknown. The lipidome may allow the individualization of a high risk population of women, who may be targeted for a dietary prevention of breast cancer. The setting and validation of a high-throughput lipidomic station with analytical capabilities fitted to the need of mass screening is required. These two locks must be resolved before a primary prevention of breast cancer by diet could be contemplated.
authors.affiliation: INSERM U921 Nutrition, Croissance et Cancer, HS Kaplan Cancer Center - CHU Bretonneau, 2 bis Boulevard Tonnellé, 37044 Tours, France. bougnoux@med.univ-tours.fr
authors.forename: Philippe
authors.initials: P
authors.lastname: Bougnoux
authors.forename: Nawale
authors.initials: N
authors.lastname: Hajjaji
authors.forename: Charles
authors.initials: C
authors.lastname: Couet
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000378:metabolism / Q000517:prevention & control; D004034:Diet Surveys; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D012307:Risk Factors
chemical_list: D014408:Biomarkers, Tumor; D005227:Fatty Acids