Nanocrystal core high-density lipoproteins: a multimodality contrast agent platform.
High density lipoprotein (HDL) is an important natural nanoparticle that may be modified for biomedical imaging purposes. Here we developed a novel technique to create unique multimodality HDL mimicking nanoparticles by incorporation of gold, iron oxide, or quantum dot nanocrystals for computed tomography, magnetic resonance, and fluorescence imaging, respectively. By including additional labels in the corona of the particles, they were made multifunctional. The characteristics of these nanoparticles, as well as their in vitro and in vivo behavior, revealed that they closely mimic native HDL.
Cormode
David P
DP
Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1234, New York, New York 10029, USA.
Skajaa
Torjus
T
van Schooneveld
Matti M
MM
Koole
Rolf
R
Jarzyna
Peter
P
Lobatto
Mark E
ME
Calcagno
Claudia
C
Barazza
Alessandra
A
Gordon
Ronald E
RE
Zanzonico
Pat
P
Fisher
Edward A
EA
Fayad
Zahi A
ZA
Mulder
Willem J M
WJ
D000818:Animals; D002460:Cell Line; D003287:Contrast Media / Q000737:chemistry*; D006046:Gold / Q000737:chemistry; D008075:Lipoproteins, HDL / Q000737:chemistry* / Q000648:ultrastructure; D008264:Macrophages / Q000648:ultrastructure; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D051379:Mice; D046529:Microscopy, Electron, Transmission
D003287:Contrast Media; D008075:Lipoproteins, HDL; D006046:Gold