[Genome-wide association studies].
Within the last year, genome-wide association (GWA) studies have identified a large number of robust associations between genetic variants and common diseases. Two key premises underlie this burst of discovery. First, the HapMap project has provided a catalogue of human genetic variation. Second, genotyping microarrays can now assess up to 1 million SNPs, allowing hypothesis-free screening of the entire genome. An important next step will be to elucidate the mechanisms behind genotype-phenotype associations. Ultimately, the goal is improved prevention, diagnosis and therapy.
Feenstra
Bjarke
B
Afdeling for Epidemiologisk Forskning, Statens Serum Institut, Artillerivej 5, DK-2300 København S. fee@ssi.dk
Boyd
Heather Allison
HA
Melbye
Mads
M
D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D015894:Genome, Human; D005838:Genotype; D006238:Haploidy; D006801:Humans; D020641:Polymorphism, Single Nucleotide