title: Thrombophilic gene polymorphisms are risk factors for unexplained infertility.
abstract: Earlier studies have shown inherited thrombophilia to be a risk factor for recurrent implantation failure, raising the question of whether this risk is related to the underlying cause of unexplained infertility or to the mechanisms involved in the implantation process. When nine thrombophilic gene polymorphisms were compared among 92 women with the diagnosis of unexplained infertility and 60 fertile control women, women with a history of unexplained infertility displayed a higher prevalence of MTHFR C677T polymorphisms than control women.
authors.affiliation: Pregnancy Success Center and Rinehart Center for Reproductive Medicine, Chicago, Illinois, USA. cbcoulam@aol.com
authors.forename: Carolyn B
authors.initials: CB
authors.lastname: Coulam
authors.forename: R S
authors.initials: RS
authors.lastname: Jeyendran
mesh_terms: D016022:Case-Control Studies; D010064:Embryo Implantation; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007247:Infertility, Female / Q000235:genetics* / Q000628:therapy; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D017211:Treatment Failure
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)