Continuous regional arterial infusion therapy for acute necrotizing pancreatitis due to Mycoplasma pneumoniae infection in a child.
A case of acute necrotizing pancreatitis due to Mycoplasma pneumoniae infection was treated in an 8-year-old girl. She experienced acute pancreatitis during treatment for M. pneumoniae. Contrast-enhanced computed tomographic scan revealed necrotizing pancreatitis. The computed tomographic severity index was 8 points (grade E). A protease inhibitor, ulinastatin, was provided via intravenous infusion but was ineffective. Continuous regional arterial infusion therapy was provided with gabexate mesilate (FOY-007, a protease inhibitor) and meropenem trihydrate, and the pancreatitis improved. This case suggests that infusion therapy is safe and useful in treating necrotizing pancreatitis in children.
Nakagawa
Motoo
M
Department of Radiology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan. lmloltlolol@gmail.com
Ogino
Hiroyuki
H
Shimohira
Masashi
M
Hara
Masaki
M
Shibamoto
Yuta
Y
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D003287:Contrast Media; D004359:Drug Therapy, Combination; D005260:Female; D016670:Gabexate / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007261:Infusions, Intra-Arterial; D000077731:Meropenem; D009177:Mycoplasma pneumoniae / Q000302:isolation & purification*; D019283:Pancreatitis, Acute Necrotizing / Q000188:drug therapy* / Q000382:microbiology*; D011019:Pneumonia, Mycoplasma / Q000150:complications*; D015842:Serine Proteinase Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D013845:Thienamycins / Q000008:administration & dosage / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
D000900:Anti-Bacterial Agents; D003287:Contrast Media; D015842:Serine Proteinase Inhibitors; D013845:Thienamycins; D016670:Gabexate; D000077731:Meropenem