Systemic blood coagulation activation in acute coronary syndromes.
We evaluated systemic alterations to the blood coagulation system that occur during a coronary thrombotic event. Peripheral blood coagulation in patients with acute coronary thrombosis was compared with that in people with stable coronary artery disease (CAD). Blood coagulation and platelet activation at the microvascular injury site were assessed using immunochemistry in 28 non-anticoagulated patients with acute myocardial infarction (AMI) versus 28 stable CAD patients matched for age, sex, risk factors, and medications. AMI was associated with increased maximum rates of thrombin-antithrombin complex generation (by 93.8%; P< .001), thrombin B-chain formation (by 57.1%; P< .001), prothrombin consumption (by 27.9%; P= .012), fibrinogen consumption (by 27.0%; P= .02), factor (f) Va light chain generation (by 44.2%; P= .003), and accelerated fVa inactivation (by 76.1%; P< .001), and with enhanced release of platelet-derived soluble CD40 ligand (by 44.4%; P< .001). FVa heavy chain availability was similar in both groups because of enhanced formation and activated protein C (APC)-mediated destruction. The velocity of coagulant reactions in AMI patients showed positive correlations with interleukin-6. Heparin treatment led to dampening of coagulant reactions with profiles similar to those for stable CAD. AMI-induced systemic activation of blood coagulation markedly modifies the pattern of coagulant reactions at the site of injury in peripheral vessels compared with that in stable CAD patients.
Undas
Anetta
A
Institute of Cardiology, Jagiellonian University School of Medicine, Krakow, Poland.
Szułdrzyński
Konstanty
K
Brummel-Ziedins
Kathleen E
KE
Tracz
Wiesława
W
Zmudka
Krzysztof
K
Mann
Kenneth G
KG
D054058:Acute Coronary Syndrome / Q000097:blood* / Q000378:metabolism; D000368:Aged; D001777:Blood Coagulation / Q000502:physiology*; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000097:blood / Q000378:metabolism; D005165:Factor V / Q000502:physiology; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation / Q000502:physiology; D011516:Prothrombin / Q000378:metabolism; D013917:Thrombin / Q000378:metabolism; D013997:Time Factors
C035876:factor V clotting antigen; D005165:Factor V; D011516:Prothrombin; D005340:Fibrinogen; D013917:Thrombin