title: Potential utility of peripherally applied loperamide in oral chronic graft-versus-host disease related pain.
abstract: Four patients with oral chronic graft-versus-host disease pain were treated with loperamide oral-rinse solution. Two-week continued use of the drug solution improved not only the pain scores but also the pain-causing disabilities associated with eating, drinking and sleeping, with no noticeable side effects. Current results suggest that the mu-opioid agonist, loperamide, has a potential analgesic effect that could be clinically used as a peripheral analgesic agent for stomatitis pain. However, these observations will need to be further confirmed in a randomized-controlled trial.
authors.affiliation: Department of Anesthesiology and Palliative Medicine, Chiba University Graduate School of Medicine, Chuo, Chiba, Japan. nnoztag@faculty.chiba-u.jp
authors.forename: Natsuko
authors.initials: N
authors.lastname: Nozaki-Taguchi
authors.forename: Mariko
authors.initials: M
authors.lastname: Shutoh
authors.forename: Naohito
authors.initials: N
authors.lastname: Shimoyama
mesh_terms: D000328:Adult; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D002908:Chronic Disease; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications*; D006801:Humans; D008139:Loperamide / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes; D010146:Pain / Q000188:drug therapy* / Q000209:etiology*; D011788:Quality of Life; D017450:Receptors, Opioid, mu / Q000819:agonists*; D013280:Stomatitis / Q000150:complications* / Q000209:etiology
chemical_list: D000700:Analgesics; D009067:Mouthwashes; D017450:Receptors, Opioid, mu; D008139:Loperamide