Posttranslational regulation of surfactant protein B expression.
Although a minor constituent by weight, surfactant protein B (SP-B) plays a major role in surfactant function. It is the unique structure of SP-B that promotes permeabilization, cross-linking, mixing, and fusion of phospholipids, facilitating the proper structure and function of pulmonary surfactant as well as contributing to the formation of lamellar bodies. SP-B production is a complex process within alveolar type 2 cells and is under hormonal and developmental control. Understanding the posttranslational events in the maturation of SP-B may provide new insight into the process of lamellar body formation and into the pathophysiology of pulmonary disorders associated with surfactant abnormalities.
Guttentag
Susan
S
Department of Pediatrics, Division of Neonatology, The University of Pennsylvania School of Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104-4318, USA.
D019281:Dimerization; D005786:Gene Expression Regulation; D006031:Glycosylation; D006801:Humans; D010447:Peptide Hydrolases / Q000378:metabolism; D017510:Protein Folding; D011498:Protein Precursors / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D011510:Proteolipids / Q000378:metabolism; D011650:Pulmonary Alveoli / Q000378:metabolism; D037701:Pulmonary Surfactant-Associated Protein B / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
D011498:Protein Precursors; D011510:Proteolipids; D037701:Pulmonary Surfactant-Associated Protein B; C105511:surfactant protein B propeptide; D010447:Peptide Hydrolases