title: Neurological complications of hematopoietic stem cell transplantation (HSCT): a retrospective study in a HSCT center in Brazil.
abstract: We present the neurological complications evaluated in a series of 1000 patients who underwent hematopoietic stem cell transplantation (HSCT). Central nervous system (CNS) neurological complications, particularly brain hemorrhages, were the most common, followed by seizures and CNS infections. An unusual neurological complication was Wernicke's encephalopathy. Less frequent neurological complications were metabolic encephalopathy, neuroleptic malignant syndrome, reversible posterior leukoencephalopathy syndrome, brain infarct and movement disorders. The most common neurological complication of the peripheral nervous system was herpes zoster radiculopathy, while peripheral neuropathies, inflammatory myopathy and myotonia were very rarely found.
authors.affiliation: Neurology Service, Internal Medicine Department, Hospital de Clínicas, Federal University of Paraná, Curitiba, PR, Brazil. hagteive@mps.com.br
authors.forename: Hélio A G
authors.initials: HA
authors.lastname: Teive
authors.forename: Vaneuza
authors.initials: V
authors.lastname: Funke
authors.forename: Marco A
authors.initials: MA
authors.lastname: Bitencourt
authors.forename: Michel Michels
authors.initials: MM
authors.lastname: de Oliveira
authors.forename: Carmen
authors.initials: C
authors.lastname: Bonfim
authors.forename: José
authors.initials: J
authors.lastname: Zanis-Neto
authors.forename: Carlos R de
authors.initials: CR
authors.lastname: Medeiros
authors.forename: Viviane F
authors.initials: VF
authors.lastname: Zétola
authors.forename: Lineu César
authors.initials: LC
authors.lastname: Werneck
authors.forename: Ricardo
authors.initials: R
authors.lastname: Pasquini
mesh_terms: D000293:Adolescent; D000328:Adult; D002493:Central Nervous System Diseases / Q000145:classification / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult