title: Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1.
abstract: The synthesis and biological activities of imidazo[5,1-f][1,2,4]triazin-2-amines (imidazotriazines) as novel polo-like kinase 1 inhibitors are reported.
authors.affiliation: GlaxoSmithKline, Fire Moore Drive, Research Triangle Park, NC 27709, USA. mui.h.cheung@gsk.com
authors.forename: M
authors.initials: M
authors.lastname: Cheung
authors.forename: K W
authors.initials: KW
authors.lastname: Kuntz
authors.forename: M
authors.initials: M
authors.lastname: Pobanz
authors.forename: J M
authors.initials: JM
authors.lastname: Salovich
authors.forename: B J
authors.initials: BJ
authors.lastname: Wilson
authors.forename: C W
authors.initials: CW
authors.lastname: Andrews
authors.forename: L M
authors.initials: LM
authors.lastname: Shewchuk
authors.forename: A H
authors.initials: AH
authors.lastname: Epperly
authors.forename: D F
authors.initials: DF
authors.lastname: Hassler
authors.forename: M A
authors.initials: MA
authors.lastname: Leesnitzer
authors.forename: J L
authors.initials: JL
authors.lastname: Smith
authors.forename: G K
authors.initials: GK
authors.lastname: Smith
authors.forename: T J
authors.initials: TJ
authors.lastname: Lansing
authors.forename: R A
authors.initials: RA
authors.lastname: Mook
mesh_terms: D000284:Administration, Oral; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D018797:Cell Cycle Proteins / Q000037:antagonists & inhibitors*; D020650:Combinatorial Chemistry Techniques; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors*; D011518:Proto-Oncogene Proteins / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D014227:Triazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000097869:Polo-Like Kinase 1
chemical_list: D000588:Amines; D000970:Antineoplastic Agents; D018797:Cell Cycle Proteins; D007093:Imidazoles; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D014227:Triazines; D000097869:Polo-Like Kinase 1