title: Inflammatory pseudotumours of the urinary bladder in dogs resembling human myofibroblastic tumours: a report of eight cases and comparative pathology.
abstract: Eight cases of inflammatory myofibroblastic tumours (IMT) of the urinary bladder in dogs are described, including their clinical, imaging, morphological, and histopathological aspects. Old small breed female dogs were more commonly affected. Haematuria was the main clinical sign, often associated with dysuria and crystalluria. The IMT appeared as single or multiple, polypoid, firm masses, measuring 1-7 cm. Histologically, the masses were well delineated, covered by a benign hyperplastic urothelium and diffusely infiltrated by a mixed inflammatory component. The cells were spindle-shaped, adopting a fascicular, pallisading or whirling organisation and were vimentin and variably desmin and actin positive. The nuclei were globular, containing open chromatin and prominent nucleoli. Mild to moderate pleomorphism and little mitotic activity were present. These morphological features are compatible with human myofibroblastic inflammatory tumours.
authors.affiliation: Department of Companion Animal Sciences, Small Animal Surgery Section, School of Veterinary Medicine, University of Liège, Belgium.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Böhme
authors.affiliation: Human Pathology Department of the Institute of Pathology and Genetic, Gosselies, Belgium.
authors.forename: Placide
authors.initials: P
authors.lastname: Ngendahayo
authors.affiliation: Department of Companion Animal Sciences, Small Animal Surgery Section, School of Veterinary Medicine, University of Liège, Belgium.
authors.forename: Annick
authors.initials: A
authors.lastname: Hamaide
authors.affiliation: Veterinary Pathology Department of Bio.be, 25 rue Georges Lemaitre, 6041 Gosselies, Hainaut, Belgium. Electronic address: marianne.heimann@ipg.be.
authors.forename: Marianne
authors.initials: M
authors.lastname: Heimann
mesh_terms: D000367:Age Factors; D000818:Animals; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D006104:Granuloma, Plasma Cell / Q000473:pathology / Q000662:veterinary*; D006801:Humans; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D009379:Neoplasms, Muscle Tissue / Q000473:pathology / Q000662:veterinary; D011379:Prognosis; D012737:Sex Factors; D001745:Urinary Bladder Diseases / Q000473:pathology / Q000662:veterinary*; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000662:veterinary