SIRTing through breast cancer is just a survivin' game.
Loss of endogenous tumor suppression is a critical step on the road to cancer. In a recent paper in Molecular Cell, Wang and colleagues provide evidence that inactivation of the pivotal BRCA1 tumor suppressor disrupts a safeguard gene network that opposes cell proliferation and cell survival.
Luo
Jianyuan
J
Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Altieri
Dario C
DC
D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics*; D049109:Cell Proliferation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D019398:Genes, BRCA1; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D008325:Mammary Neoplasms, Experimental / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000502:physiology*; D012097:Repressor Proteins; D056564:Sirtuin 1; D037761:Sirtuins / Q000235:genetics / Q000502:physiology*; D000077022:Survivin
C117749:Birc5 protein, mouse; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D012097:Repressor Proteins; D000077022:Survivin; C470545:Sirt1 protein, mouse; D056564:Sirtuin 1; D037761:Sirtuins