Management of complications of androgen deprivation therapy in the older man.
Prostate cancer is the most common malignancy in older men. With the aging of the population, the number of older men with prostate cancer will grow rapidly. Androgen deprivation therapy (ADT) is the mainstay of treatment for men with systemic disease and is increasingly utilized as primary therapy or in combination with other therapies for localized disease. Side effects of therapy are multifold and include hot flashes, osteoporosis, and adverse psychological and metabolic effects. Recent research has illustrated that ADT can negatively impact the functional, cognitive, and physical performance of older men. Patients with prostate cancer, despite recurrence of the disease, have a long life expectancy and may be subjected to the side effects of ADT for many years. This review highlights the complications of ADT and approaches to management. We also provide recommendations for assessment and management of ADT complications among the most vulnerable and frail older male patients.
Mohile
Supriya G
SG
James Wilmot Cancer Center, University of Rochester, Rochester, NY 14642, USA. supriya_mohile@urmc.rochester.edu
Mustian
Karen
K
Bylow
Kathryn
K
Hall
William
W
Dale
William
W
D000726:Androgen Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D000740:Anemia / Q000139:chemically induced / Q000628:therapy; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects* / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000139:chemically induced / Q000628:therapy; D019584:Hot Flashes / Q000139:chemically induced / Q000628:therapy; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000139:chemically induced / Q000628:therapy; D009140:Musculoskeletal Diseases / Q000139:chemically induced / Q000628:therapy; D010024:Osteoporosis / Q000139:chemically induced / Q000628:therapy; D011471:Prostatic Neoplasms / Q000150:complications / Q000628:therapy*; D011788:Quality of Life; D012735:Sexual Dysfunction, Physiological / Q000139:chemically induced / Q000628:therapy
D000726:Androgen Antagonists; D018931:Antineoplastic Agents, Hormonal