title: Role of vitamin D treatment in glucose metabolism in polycystic ovary syndrome.
abstract: OBJECTIVE
  To determine the effect of treatment with vitamin D(3) analogue in the parameters of glucose metabolism in obese women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Observational study.
  
  
  METHODS
  Obese women with PCOS in an academic research environment.
  
  
  METHODS
  Fifteen obese women (mean age 28 +/- 1.3 years, mean body mass index 32.55 +/- 0.43) with documented chronic anovulation and hyperandrogenism were recruited into the study.
  
  
  METHODS
  Alphacalcidol (1-alpha-hydroxyvitamin D(3)) was administered orally 1 microg/day for 3 months. All subjects underwent a frequently sampled IV glucose tolerance test after a 10- to 12-hour overnight fast during a spontaneous bleeding episode before and after treatment with alphacalcidol.
  
  
  METHODS
  Peripheral insulin resistance and insulin effectiveness were estimated with minimal model.
  
  
  RESULTS
  The first phase of insulin secretion was significantly increased after treatment with alphacalcidol. A favorable statistically significant change also was observed in the lipid profile.
  
  
  CONCLUSIONS
  Treatment with the vitamin D(3) analogue (alphacalcidol) could be of value in the management of PCOS.
authors.affiliation: Division of Endocrinology and Metabolism, Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece.
authors.forename: Kalliopi
authors.initials: K
authors.lastname: Kotsa
authors.affiliation: Division of Endocrinology and Metabolism, Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece.
authors.forename: Maria P
authors.initials: MP
authors.lastname: Yavropoulou
authors.affiliation: Division of Endocrinology and Metabolism, Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece.
authors.forename: Olympia
authors.initials: O
authors.lastname: Anastasiou
authors.affiliation: Division of Endocrinology and Metabolism, Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece. Electronic address: giovos@med.auth.gr.
authors.forename: John G
authors.initials: JG
authors.lastname: Yovos
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000494:pharmacology / Q000627:therapeutic use; D002118:Calcium / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005260:Female; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006801:Humans; D006887:Hydroxycholecalciferols / Q000494:pharmacology / Q000627:therapeutic use; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D050356:Lipid Metabolism / Q000187:drug effects; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology; D010281:Parathyroid Hormone / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology*; D014807:Vitamin D / Q000031:analogs & derivatives / Q000502:physiology*
chemical_list: D001786:Blood Glucose; D050071:Bone Density Conservation Agents; D006887:Hydroxycholecalciferols; D007328:Insulin; D010281:Parathyroid Hormone; D014807:Vitamin D; D005947:Glucose; D002118:Calcium; C008088:alfacalcidol