Inhibitory receptors signal activation.
Natural killer cell inhibitory receptors block effector responses by recruiting phosphatases that dephosphorylate molecules involved in activation. However, in this issue of Immunity, Peterson and Long show that inhibitory receptors also signal tyrosine phosphorylation, an event usually indicating cellular activation.
Yokoyama
Wayne M
WM
Howard Hughes Medical Institute, Rheumatology Division, Washington University School of Medicine, St. Louis, MO 63110, USA. yokoyama@im.wustl.edu
D020816:Amino Acid Motifs; D000818:Animals; D050719:Crk-Associated Substrate Protein / Q000378:metabolism; D020735:Guanine Nucleotide-Releasing Factor 2 / Q000378:metabolism; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D055650:NK Cell Lectin-Like Receptor Subfamily A / Q000276:immunology / Q000378:metabolism; D051920:NK Cell Lectin-Like Receptor Subfamily D / Q000276:immunology / Q000378:metabolism; D050736:Oncogene Protein v-crk / Q000378:metabolism; D010766:Phosphorylation; D050721:Proto-Oncogene Proteins c-cbl / Q000378:metabolism; D051567:Proto-Oncogene Proteins c-vav / Q000378:metabolism; D011971:Receptors, Immunologic / Q000276:immunology / Q000378:metabolism*; D054340:Receptors, KIR / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction; D019061:src-Family Kinases / Q000378:metabolism
D050719:Crk-Associated Substrate Protein; D020735:Guanine Nucleotide-Releasing Factor 2; D055650:NK Cell Lectin-Like Receptor Subfamily A; D051920:NK Cell Lectin-Like Receptor Subfamily D; D050736:Oncogene Protein v-crk; D051567:Proto-Oncogene Proteins c-vav; D011971:Receptors, Immunologic; D054340:Receptors, KIR; D050721:Proto-Oncogene Proteins c-cbl; D019061:src-Family Kinases