title: Delayed substantia nigra damage and leukoencephalopathy after hypoxic-ischemic injury.
abstract: Delayed post-anoxic encephalopathy has rarely been reported, and has most commonly been associated with carbon monoxide poisoning. The underlying pathophysiological mechanism is unknown. We describe a patient with a delayed neurologic decline after a good initial recovery from a hypoxic-ischemic event precipitated by acute blood loss. MRI revealed early globus pallidus necrosis followed by delayed substantia nigra damage and leukoencephalopathy. We suggest that anemia might play a role in this pattern of hypoxic-ischemic brain injury.
authors.affiliation: Department of neurology, The 2nd Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, 310009, China.
authors.forename: Min
authors.initials: M
authors.lastname: Lou
authors.forename: Chao-Hui
authors.initials: CH
authors.lastname: Jing
authors.forename: Magdy H
authors.initials: MH
authors.lastname: Selim
authors.forename: Louis R
authors.initials: LR
authors.lastname: Caplan
authors.forename: Mei-Ping
authors.initials: MP
authors.lastname: Ding
mesh_terms: D000740:Anemia / Q000150:complications / Q000473:pathology; D015140:Dementia, Vascular / Q000150:complications / Q000473:pathology*; D005260:Female; D005917:Globus Pallidus / Q000473:pathology; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000150:complications / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009336:Necrosis; D013378:Substantia Nigra / Q000473:pathology*; D013997:Time Factors