Synthesis and characterization of novel natural product-Gd(III) MRI contrast agent conjugates.
Several novel gadolinium chelates conjugated with paclitaxel, colchicine and thyroxine have been prepared as MRI contrast agents targeted to tubulin and thyroxine-binding globulin, respectively.
Efthimiadou
Eleni K
EK
Chemical Biology Program, Institute of Physical Chemistry, NCSR 'DEMOKRITOS', PO Box 60228, GR-153 10 Aghia, Paraskevi, Greece.
Katsarou
Maria E
ME
Fardis
Michael
M
Zikos
Christos
C
Pitsinos
Emmanuel N
EN
Kazantzis
Athanasios
A
Leondiadis
Leondios
L
Sagnou
Marina
M
Vourloumis
Dionisios
D
D003078:Colchicine / Q000737:chemistry; D003287:Contrast Media / Q000138:chemical synthesis* / Q000737:chemistry; D005260:Female; D005682:Gadolinium / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008279:Magnetic Resonance Imaging; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D017239:Paclitaxel / Q000737:chemistry; D013974:Thyroxine / Q000737:chemistry; D013975:Thyroxine-Binding Proteins / Q000187:drug effects*; D014404:Tubulin / Q000187:drug effects*
D003287:Contrast Media; D009942:Organometallic Compounds; D013975:Thyroxine-Binding Proteins; D014404:Tubulin; D005682:Gadolinium; D017239:Paclitaxel; D013974:Thyroxine; D003078:Colchicine