Comparative analysis of Bayer wide-range C-reactive protein (wr-CRP) and the Dade-Behring high sensitivity C-reactive protein (hs-CRP) in patients with inflammatory bowel disease.
OBJECTIVE
The recently introduced Bayerwide-range C-reactive protein (wr-CRP) assay might be relevant for the real-time low-cost and online determination of inflammatory bowel disease (IBD) activity. Our aim was to examine whether wr-CRP can substitute for the Dade Behring high sensitivity C-reactive protein (hs-CRP) assay in IBD patients.


METHODS
A total of 71 patients with IBD, of whom 48 had Crohn's disease CD and 23 had ulcerative colitis (UC) with various intensities of disease activity participated in the study. The CRP of patients who were under treatment at the Department of Gastroenterology and Liver Diseases were measured using both wr-CRP and the hs-CRP.


RESULTS
A significant (r = 0.995; P < 0.001) correlation was noted between the hs-CRP and wr-CRP measurements for the whole sample as well as for the two diseases, CD (r = 0.994; P < 0.001) and UC (r = 0.997; P < 0.001), which were analyzed separately.


CONCLUSIONS
The Bayer wr-CRP assay might be a useful low-cost and real-time inflammation-sensitive biomarker in patients with IBD.
Maharshak
Nitsan
N
Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Arbel
Yaron
Y
Gal-Oz
Amir
A
Rogowski
Ori
O
Shapira
Itzhak
I
Berliner
Shlomo
S
Vered
Yaffa
Y
Canaani
Jonathan
J
Dotan
Iris
I
D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D003093:Colitis, Ulcerative / Q000097:blood* / Q000175:diagnosis; D003424:Crohn Disease / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D007158:Immunologic Techniques; D009391:Nephelometry and Turbidimetry
D015415:Biomarkers; D002097:C-Reactive Protein