title: Predicting response to CRT. The value of two- and three-dimensional echocardiography.
abstract: Recently, it has been suggested that a direct assessment of left ventricular (LV) mechanical dyssynchrony may improve the selection of candidates to cardiac resynchronization therapy (CRT). In fact, when the established clinical and electrocardiographic selection criteria are applied, response to CRT may vary widely and up to one-third of the patients fail to benefit from CRT. Echocardiography has been extensively applied to assess LV dyssynchrony and to predict favourable response to CRT, using different two- and three-dimensional modalities. In this review, the value of these echocardiographic modalities will be discussed, highlighting the advantages and drawbacks of each technique and evaluating the clinical implications and future perspectives of LV dyssynchrony assessment.
authors.affiliation: Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands. n.ajmone@lumc.nl
authors.forename: Nina Ajmone
authors.initials: NA
authors.lastname: Marsan
authors.forename: Ole A
authors.initials: OA
authors.lastname: Breithardt
authors.forename: Victoria
authors.initials: V
authors.lastname: Delgado
authors.forename: Matteo
authors.initials: M
authors.lastname: Bertini
authors.forename: Laurens F
authors.initials: LF
authors.lastname: Tops
mesh_terms: D002304:Cardiac Pacing, Artificial / Q000379:methods*; D019560:Echocardiography, Three-Dimensional / Q000379:methods*; D017063:Outcome Assessment, Health Care / Q000379:methods*; D011379:Prognosis; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000517:prevention & control*