Pharmacokinetics of intravenously administered moxifloxacin in eye compartments: an experimental study.
The purpose of this study was to evaluate the pharmacokinetics of intravenously administered moxifloxacin, a fourth-generation fluoroquinolone, in different parts of the non-inflamed eye. Moxifloxacin was administered intravenously at a dose of 20mg/kg moxifloxacin over 30min. Sampling of peripheral blood, aqueous humour and vitreous was performed at standard time intervals post infusion once in each animal. Moxifloxacin levels were estimated by high-performance liquid chromatography with fluorescence detection. Mean serum concentrations were 3.43, 2.74, 1.48 and 1.12microg/mL at 0.5, 3, 6 and 24h after the end of drug infusion, respectively. Respective concentrations in aqueous humour were 2.44, 2.03, 1.30 and 1.09microg/mL and in vitreous body they were 1.68, 1.87, 1.78 and 1.15microg/mL. It is concluded that systemic administration of moxifloxacin in rabbits was accompanied by efficient penetration into both the aqueous humour and the vitreous body at concentrations well above the minimum inhibitory concentration for most causative pathogens of endophthalmitis. Further research is mandatory to clarify the clinical significance of these findings.
Tzepi
Ira
I
4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece.
Vergados
Ioannis
I
Kanellakopoulou
Kyriaki
K
Papathanassiou
Miltiadis
M
Kranidioti
Hariklia
H
Tsaganos
Thomas
T
Liarakos
Vassilios
V
Giamarellos-Bourboulis
Evangelos J
EJ
Theodossiadis
Panagiotis
P
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001372:Aza Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005123:Eye / Q000737:chemistry*; D024841:Fluoroquinolones; D007262:Infusions, Intravenous; D008297:Male; D023421:Models, Animal; D000077266:Moxifloxacin; D010949:Plasma / Q000737:chemistry; D011804:Quinolines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011817:Rabbits
D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D000077266:Moxifloxacin