[Venous thrombosis and bowel perforation].
In cancer chemotherapy, serious complications including arterial and venous thrombosis and occlusion may occur, especially when bevacizumab(Bmab)is administered. Low-molecular weight heparin(LMWH)is recommended for the treatment of venous thrombosis in the guideline of Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer' by ASCO. Full-dose anticoagulation is reported to raise no risk of bleeding tendency. For a bowel perforation case, emergency operation may be required. In the treatment of such complications, wound healing delay due to Bmab administration has to be taken into account.
Uetake
Hiroyuki
H
Department of Translational Oncology, Tokyo Medical and Dental Universty, Tokyo, Japan.
Ishikawa
Toshiaki
T
Sugihara
Kenichi
K
D000911:Antibodies, Monoclonal / Q000009:adverse effects / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000068258:Bevacizumab; D006801:Humans; D007416:Intestinal Perforation / Q000139:chemically induced* / Q000601:surgery; D009369:Neoplasms / Q000188:drug therapy; D012307:Risk Factors; D020246:Venous Thrombosis / Q000139:chemically induced* / Q000188:drug therapy
D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D000068258:Bevacizumab