title: Increased expression of T-bet in circulating B cells from a patient with multiple sclerosis and celiac disease.
abstract: Multiple sclerosis (MS) and celiac disease (CD) are considered to be T-cell-mediated autoimmune diseases. We describe a woman affected by a relapsing-remitting demyelinating disease of the central nervous system and occult CD (MS-CD), who showed during neurologic exacerbations a strong increased expression of T-bet, the key transcription factor for the development of Th1 cells, in circulating T, B cells and monocytes. Conversely, no difference of T-bet expression was observed in B cells from relapsing-remitting MS patients, either in relapse or in remission, and in controls. In the MS-CD patient, the interaction between MS- and CD-related inflammatory processes may result in an amplification of Th1 immune response.
authors.affiliation: Institute of Neurology, Department of Neurosciences, Catholic University, Rome, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Frisullo
authors.forename: Viviana
authors.initials: V
authors.lastname: Nociti
authors.forename: Raffaele
authors.initials: R
authors.lastname: Iorio
authors.forename: Agata Katia
authors.initials: AK
authors.lastname: Patanella
authors.forename: Alessandro
authors.initials: A
authors.lastname: Marti
authors.forename: Giovanni
authors.initials: G
authors.lastname: Cammarota
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Mirabella
authors.forename: Pietro
authors.initials: P
authors.lastname: Attilio Tonali
authors.forename: Anna Paola
authors.initials: AP
authors.lastname: Batocchi
mesh_terms: D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D002446:Celiac Disease / Q000097:blood / Q000150:complications / Q000276:immunology* / Q000503:physiopathology; D055050:Diet, Gluten-Free; D018450:Disease Progression; D005260:Female; D006261:Headache; D006801:Humans; D006987:Hypesthesia; D007231:Infant, Newborn; D007371:Interferon-gamma / Q000378:metabolism; D008213:Lymphocyte Activation; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D009000:Monocytes / Q000276:immunology / Q000378:metabolism*; D009103:Multiple Sclerosis / Q000097:blood / Q000150:complications / Q000276:immunology* / Q000503:physiopathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000276:immunology / Q000503:physiopathology; D011961:Receptors, Fc / Q000097:blood; D020127:Recovery of Function; D012075:Remission, Spontaneous; D020825:T-Box Domain Proteins / Q000097:blood* / Q000235:genetics; D015533:Transcriptional Activation; D011503:Transglutaminases / Q000276:immunology; D000098815:T-bet Transcription Factor
chemical_list: C068317:IgA, secretory receptor; D011961:Receptors, Fc; D020825:T-Box Domain Proteins; D000098815:T-bet Transcription Factor; D007371:Interferon-gamma; D011503:Transglutaminases; D008775:Methylprednisolone