title: Regulation of phospholipid synthesis in yeast.
abstract: Phospholipid synthesis in the yeast Saccharomyces cerevisiae is a complex process that involves regulation by both genetic and biochemical mechanisms. The activity levels of phospholipid synthesis enzymes are controlled by gene expression (e.g., transcription) and by factors (lipids, water-soluble phospholipid precursors and products, and covalent modification of phosphorylation) that modulate catalysis. Phosphatidic acid, whose levels are controlled by the biochemical regulation of key phospholipid synthesis enzymes, plays a central role in the regulation of phospholipid synthesis gene expression.
authors.affiliation: Department of Food Science and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ 08901, USA. carman@aesop.rutgers.edu
authors.forename: George M
authors.initials: GM
authors.lastname: Carman
authors.forename: Gil-Soo
authors.initials: GS
authors.lastname: Han
mesh_terms: D019852:Diacylglycerol Kinase / Q000378:metabolism; D007294:Inositol / Q000378:metabolism; D010712:Phosphatidic Acids / Q000378:metabolism; D010743:Phospholipids / Q000096:biosynthesis*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D015032:Zinc / Q000378:metabolism
chemical_list: D010712:Phosphatidic Acids; D010743:Phospholipids; D007294:Inositol; D019852:Diacylglycerol Kinase; D015032:Zinc