Dioxin-like activity in plasma among Danish pregnant women: dietary predictors, birth weight and infant development.
The aim of this study was to identify dietary predictors of plasma dioxin-like activity in women from the Danish National Birth Cohort. Associations between exposure and birth weight and infant development at 6 months were also explored. Diet was assessed in mid-pregnancy by a food-frequency questionnaire. One hundred nulliparous 25-35-year-old women of normal pre-pregnancy body-mass-index were chosen according to their intake of fatty fish, as fatty fish is a potential route of exposure. Intake of other foods of animal origin was also explored. Dioxin-like activity was measured in plasma using the Dioxin-Responsive Chemically Activated LUciferase eXpression (DR-CALUX) and quantified in toxic equivalents (CALUX-TEQs). Information on infant attainment of specific milestones was obtained by maternal report in a standardized interview. The sample mean was 46 pg CALUX-TEQ/g lipid. Plasma dioxin-like activity increased by 10.7 pg CALUX-TEQ/g lipid (95% CI: 1.8; 19.7) for the highest compared to the lowest tertile of total dietary fat intake but decreased by -9.8 pg CALUX-TEQ/g lipid (95% CI: -19.4; -0.2) for fatty fish intake. The inverse association for fatty fish was explained by lower intake of high-fat food groups such as red meat, fats and oils, which were also predictors of dioxin-like activity. Plasma dioxin-like activity was not associated with birth weight, but an inverse correlation was observed with total developmental score (Spearman r=-0.23, p=0.046). Our study indicates that dietary patterns associated with high fat intake may lead to increased plasma dioxin-like activity and in utero exposure might be related to early infant development.
Halldorsson
Th I
TI
Maternal Nutrition Group, Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, Building 206, 2300 Copenhagen, Denmark. lur@ssi.dk
Thorsdottir
I
I
Meltzer
H M
HM
Strøm
M
M
Olsen
S F
SF
D000328:Adult; D001724:Birth Weight / Q000187:drug effects*; D002657:Child Development / Q000187:drug effects*; D015331:Cohort Studies; D003718:Denmark; D004032:Diet; D004147:Dioxins / Q000097:blood / Q000633:toxicity; D004785:Environmental Pollutants / Q000097:blood / Q000633:toxicity; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D018811:Maternal Exposure / Q000009:adverse effects; D011237:Predictive Value of Tests; D011247:Pregnancy
D004147:Dioxins; D004785:Environmental Pollutants