title: Understanding the association of apolipoprotein E4 with Alzheimer disease: clues from its structure.
abstract: Despite intense interest, the molecular mechanisms underlying the association of apoE4 with Alzheimer disease are not clear. Because the function (or dysfunction) of a protein is based on its structure, this review focuses on the effects of the structural differences among the isoforms on neurodegeneration. Understanding how apoE4 structure impacts neurodegeneration is likely to provide mechanistic insight as well as potential therapeutic approaches to blunt or reduce its effects.
authors.affiliation: Gladstone Institute of Neurological Disease, San Francisco, California 94158, USA.
authors.forename: Ning
authors.initials: N
authors.lastname: Zhong
authors.forename: Karl H
authors.initials: KH
authors.lastname: Weisgraber
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D053327:Apolipoprotein E4 / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D017434:Protein Structure, Tertiary / Q000235:genetics; D013329:Structure-Activity Relationship
chemical_list: D053327:Apolipoprotein E4; D020033:Protein Isoforms