Therapeutic effect of traditional Chinese medicine on coagulation disorder and accompanying intractable jaundice in hepatitis B virus-related liver cirrhosis patients.
OBJECTIVE
To observe the therapeutic effects of new traditional Chinese medicine (TCM) therapy on coagulation disorder and accompanying intractable jaundice in HBV-related liver cirrhosis patients.


METHODS
Using stratified random sampling according to fibrinogen (Fib) levels, 145 liver cirrhosis patients due to hepatitis B complicated by coagulation disorder were treated. Of them, 70 in research group were treated with TCM by "nourishing yin, cooling blood and invigorating blood circulation" and Western medicine, 75 in control group were treated with conventional Western medicine. The indexes of liver function, coagulation function and bleeding events were observed and compared.


RESULTS
The prothrombin time (PT) was shorter and the fibrinogen (Fib) level was higher in the research group than in the control group (Fib = 1.6-2.0 g/L, 1.1-1.5 g/L, and < or = 1.0 g/L). The total bilirubin (TBIL) level was significantly lower in the research group than in the control group, except for the subgroup of FIB < or = 1.0 g/L.


CONCLUSIONS
TCM therapy can improve coagulation fuction and decrease TBIL.
Li
Yang-Mei
YM
Department of TCM, The Third Affiliated Hospital of Sun Yat-Sen University, Guangdong Province, China.
Yang
Hong-Zhi
HZ
Guan
Wei-Bing
WB
Ke
Qian-Shan
QS
Dai
Min
M
Xie
He-Ping
HP
Zhang
Shi-Jun
SJ
D000328:Adult; D001663:Bilirubin / Q000378:metabolism; D001775:Blood Circulation / Q000502:physiology; D001777:Blood Coagulation / Q000502:physiology; D001778:Blood Coagulation Disorders / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006509:Hepatitis B / Q000150:complications*; D006515:Hepatitis B virus; D006801:Humans; D007565:Jaundice / Q000209:etiology / Q000378:metabolism / Q000628:therapy*; D008103:Liver Cirrhosis / Q000150:complications* / Q000821:virology*; D008297:Male; D008516:Medicine, Chinese Traditional / Q000379:methods*; D008875:Middle Aged; D011517:Prothrombin Time; D012189:Retrospective Studies; D016896:Treatment Outcome
D005340:Fibrinogen; D001663:Bilirubin