title: Uapaca genus (Euphorbiaceae), a good source of betulinic acid.
abstract: Betulinic acid, isolated in substantial amounts from stem barks of five distinct species of Uapaca could be considered as an important chemotaxomic marker of the Uapaca genus. It inhibited Trypanosoma brucei GAPDH with an IC(50) value of 240 microM and has been shown to be a competitive reversible inhibitor (Ki=200+/-10 microM) of this enzyme with respect to its cofactor NAD(+).
authors.affiliation: Laboratory of Medicinal Chemistry, Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Box 812 Yaoundé, Cameroon. bnyasse@yahoo.com
authors.forename: Barthelemy
authors.initials: B
authors.lastname: Nyasse
authors.forename: Jean-Jules
authors.initials: JJ
authors.lastname: Nono
authors.forename: Yves
authors.initials: Y
authors.lastname: Nganso
authors.forename: Igor
authors.initials: I
authors.lastname: Ngantchou
authors.forename: Bernd
authors.initials: B
authors.lastname: Schneider
mesh_terms: D000818:Animals; D019665:Euphorbiaceae / Q000737:chemistry*; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000037:antagonists & inhibitors*; D015394:Molecular Structure; D009243:NAD / Q000037:antagonists & inhibitors*; D053978:Pentacyclic Triterpenes; D024301:Plant Bark; D010936:Plant Extracts / Q000493:pharmacokinetics / Q000494:pharmacology*; D018547:Plant Stems; D014315:Triterpenes / Q000302:isolation & purification* / Q000493:pharmacokinetics / Q000494:pharmacology; D014346:Trypanosoma brucei brucei / Q000201:enzymology*; D000094062:Betulinic Acid
chemical_list: D053978:Pentacyclic Triterpenes; D010936:Plant Extracts; D014315:Triterpenes; D009243:NAD; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D000094062:Betulinic Acid