Efficacy and tolerability at 3 and 6 months following use of azathioprine  for recalcitrant atopic dermatitis in children and young adults.
BACKGROUND
Recalcitrant childhood atopic dermatitis (AD) causes significant morbidity and may necessitate systemic treatment with immunomodulating agents such as azathioprine. We reviewed the clinical and biochemical effects of this agent in children and adolescents receiving this treatment between November 2005 and December 2007.


METHODS
The clinical efficacy of azathioprine, and its hematological and biochemical effects (serum IgE level, liver and renal function), were assessed at 3 months and 6 months in 17 cases of recalcitrant AD. Disease severity was evaluated with the SCORing Atopic Dermatitis (SCORAD) score which has two components, namely (1) the objective SCORAD which measures the extent (percentage of body surface area involved) and intensity of the lesions, and (2) visual analog scales which measure the subjective symptoms of pruritus and sleep loss.


RESULTS
There were nine males and eight females with a mean (SD) age of 16.1 (3.9) years. Compared with baseline, significant improvements were observed at 3 months (n = 17) and 6 months (n = 16) in SCORAD (p = 0.002; p < 0.001), objective SCORAD (p = 0.002; p = 0.001), extent (p = 0.001; p < 0.001), pruritus (p = 0.004; p = 0.001) and dryness (p = 0.033 at 6 months). Compared with males, objective SCORAD was significantly lower in females (p = 0.009) at 6 months. Azathioprine was stopped in one female after 4 months due to lack of efficacy. Serum total IgE (p = 0.006) was significantly lower at 6 months. The frequency of oral antihistamine usage and Staphylococcus aureus carriage were also significantly reduced (p = 0.031 and p = 0.016, respectively). Mild transient elevation of glutamic-pyruvic transaminase in one patient which became normalized on cessation of the drug, and mild elevation of serum bilirubin in two other patients were observed.


CONCLUSIONS
Azathioprine reduced the disease severity of AD within 3 months of use in these children. Better efficacy was observed in females at 6 months. Adverse hematologic and biochemical effects appeared acceptable but longer-term monitoring is desirable.
Hon
Kam-Lun E
KL
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, People's Republic of China. ehon@cuhk.edu.hk
Ching
Gary K W
GK
Leung
Ting-Fan
TF
Chow
Chung-Mo
CM
Lee
Kenneth K C
KK
Ng
Pak-Cheung
PC
D000293:Adolescent; D000367:Age Factors; D001379:Azathioprine / Q000008:administration & dosage* / Q000009:adverse effects; D002648:Child; D003876:Dermatitis, Atopic / Q000175:diagnosis / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D020714:Maximum Tolerated Dose; D011336:Probability; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D012737:Sex Factors; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
D007166:Immunosuppressive Agents; D001379:Azathioprine