Hodgkin lymphoma as second malignancy during continuing chemotherapy for childhood acute lymphoblastic leukemia.
Acute lymphoblastic leukemia (ALL) is the most prevalent childhood malignancy in most parts of the world with a 5-year survival rate above 70%. Long-term survivors are at risk for treatment-related late effects and second malignant neoplasms (SMNs). SMNs occur with a mean latency of 6-6.7 years after ALL diagnosis but are rarely observed during maintenance chemotherapy (CT). Hodgkin lymphoma (HL) as a complication of ALL is very rare. We report two children with ALL who developed HL while receiving maintenance CT. Both received appropriate chemo- and radiotherapy (CT/RT) and have survived for more than10 years.
Alebouyeh
M
M
Department of Pediatric Hematology and Oncology, Shohada Medical Center, Shaheed Beheshti University of Medical Sciences, Tehran-Tajrish, Iran. alebouyehm@yahoo.com
Moussavi
F
F
Haddad-Deylami
H
H
Vossough
P
P
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001706:Biopsy; D002675:Child, Preschool; D005500:Follow-Up Studies; D006689:Hodgkin Disease / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D008134:Long-Term Care; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary / Q000139:chemically induced* / Q000175:diagnosis; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*