Interactions of ibuprofen with hybrid lipid bilayers probed by complementary surface-enhanced vibrational spectroscopies.
The incorporation of small molecules into lipid bilayers is a process of biological importance and clinical relevance that can change the material properties of cell membranes and cause deleterious side effects for certain drugs. Here we report the direct observation, using surface-enhanced Raman and IR spectroscopies (SERS, SEIRA), of the insertion of ibuprofen molecules into hybrid lipid bilayers. The alkanethiol-phospholipid hybrid bilayers were formed onto gold nanoshells by self-assembly, where the underlying nanoshell substrates provided the necessary enhancements for SERS and SEIRA. The spectroscopic data reveal specific interactions between ibuprofen and phospholipid moieties and indicate that the overall hydrophobicity of ibuprofen plays an important role in its intercalation in these membrane mimics.
Levin
Carly S
CS
Department of Chemistry, Department of Bioengineering, Department of Electrical and Computer Engineering, Rice University, P.O. Box 1892, Houston, Texas 77251-1892, USA.
Kundu
Janardan
J
Janesko
Benjamin G
BG
Scuseria
Gustavo E
GE
Raphael
Robert M
RM
Halas
Naomi J
NJ
D000327:Adsorption; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D007052:Ibuprofen / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013059:Spectrum Analysis, Raman; D013499:Surface Properties; D014732:Vibration
D000894:Anti-Inflammatory Agents, Non-Steroidal; D008051:Lipid Bilayers; D007052:Ibuprofen