title: Mycosis fungoides with focal CD 30 transformation in an adolescent.
abstract: Mycosis fungoides is rare in children and adolescents. Large cell transformation in mycosis fungoides is typically seen in adult patients with advanced disease. We describe a 16-year-old girl with patch/plaque stage mycosis fungoides who developed a nodule within one of the plaques, which on histopathology showed large cell transformation, with positive labeling with the CD30 immunostain. To the best of our knowledge, this is the second reported case of mycosis fungoides with CD30+ large cell transformation in a child.
authors.affiliation: Department of Dermatology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA. mmromero@salud.unm.edu
authors.forename: Monica
authors.initials: M
authors.lastname: Romero
authors.forename: Michaela
authors.initials: M
authors.lastname: Haney
authors.forename: Emily
authors.initials: E
authors.lastname: Desantis
authors.forename: Barrett
authors.initials: B
authors.lastname: Zlotoff
mesh_terms: D000293:Adolescent; D001706:Biopsy; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D005260:Female; D006801:Humans; D017730:Ki-1 Antigen / Q000378:metabolism*; D009182:Mycosis Fungoides / Q000378:metabolism* / Q000473:pathology*; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology*; D013601:T-Lymphocytes / Q000378:metabolism / Q000473:pathology
chemical_list: D017730:Ki-1 Antigen