Pyoderma gangrenosum following isotretinoin therapy for acne nodulocystic.
A 19-year-old man with nodulocystic acne on baseline was treated with isotretinoin therapy. After 1 month on the medication, he developed pyoderma gangrenosum on his pubis area, arms and legs, and pathergy on a puncture site. Possible underlying diseases were excluded. The patient was started on steroids (prednisone 1 mg/kg/d) and isotretinoin therapy was withdrawn. Later the prednisone was tapered and dapsone 100 mg/daily was initiated. After 10 months of follow-up all lesions had healed and no underlying diseases developed.
Tinoco
Maria Paula
MP
Department of Dermatology, Instituto de Dermatologia Prof Rubem David Azulay, Rio de Janeiro, Brazil. mpaulatinoco@gmail.com
Tamler
Carla
C
Maciel
Gustavo
G
Soares
Deborah
D
Avelleira
João Carlos
JC
Azulay
David
D
D000152:Acne Vulgaris / Q000188:drug therapy* / Q000473:pathology; D003622:Dapsone / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D017511:Pyoderma Gangrenosum / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome; D055815:Young Adult
D003622:Dapsone; D015474:Isotretinoin; D011241:Prednisone