title: Receptor-like kinase ACR4 restricts formative cell divisions in the Arabidopsis root.
abstract: During the development of multicellular organisms, organogenesis and pattern formation depend on formative divisions to specify and maintain pools of stem cells. In higher plants, these activities are essential to shape the final root architecture because the functioning of root apical meristems and the de novo formation of lateral roots entirely rely on it. We used transcript profiling on sorted pericycle cells undergoing lateral root initiation to identify the receptor-like kinase ACR4 of Arabidopsis as a key factor both in promoting formative cell divisions in the pericycle and in constraining the number of these divisions once organogenesis has been started. In the root tip meristem, ACR4 shows a similar action by controlling cell proliferation activity in the columella cell lineage. Thus, ACR4 function reveals a common mechanism of formative cell division control in the main root tip meristem and during lateral root initiation.
authors.affiliation: Department of Plant Systems Biology, Flanders Institute for Biotechnology (VIB), B-9052 Ghent, Belgium.
authors.forename: Ive
authors.initials: I
authors.lastname: De Smet
authors.forename: Valya
authors.initials: V
authors.lastname: Vassileva
authors.forename: Bert
authors.initials: B
authors.lastname: De Rybel
authors.forename: Mitchell P
authors.initials: MP
authors.lastname: Levesque
authors.forename: Wim
authors.initials: W
authors.lastname: Grunewald
authors.forename: Daniël
authors.initials: D
authors.lastname: Van Damme
authors.forename: Giel
authors.initials: G
authors.lastname: Van Noorden
authors.forename: Mirande
authors.initials: M
authors.lastname: Naudts
authors.forename: Gert
authors.initials: G
authors.lastname: Van Isterdael
authors.forename: Rebecca
authors.initials: R
authors.lastname: De Clercq
authors.forename: Jean Y
authors.initials: JY
authors.lastname: Wang
authors.forename: Nicholas
authors.initials: N
authors.lastname: Meuli
authors.forename: Steffen
authors.initials: S
authors.lastname: Vanneste
authors.forename: Jirí
authors.initials: J
authors.lastname: Friml
authors.forename: Pierre
authors.initials: P
authors.lastname: Hilson
authors.forename: Gerd
authors.initials: G
authors.lastname: Jürgens
authors.forename: Gwyneth C
authors.initials: GC
authors.lastname: Ingram
authors.forename: Dirk
authors.initials: D
authors.lastname: Inzé
authors.forename: Philip N
authors.initials: PN
authors.lastname: Benfey
authors.forename: Tom
authors.initials: T
authors.lastname: Beeckman
mesh_terms: D017360:Arabidopsis / Q000166:cytology* / Q000201:enzymology* / Q000235:genetics / Q000254:growth & development; D029681:Arabidopsis Proteins / Q000235:genetics* / Q000378:metabolism*; D002455:Cell Division; D019070:Cell Lineage; D020869:Gene Expression Profiling; D018506:Gene Expression Regulation, Plant; D017343:Genes, Plant; D018519:Meristem / Q000166:cytology* / Q000201:enzymology / Q000254:growth & development; D009154:Mutation; D018517:Plant Roots / Q000166:cytology* / Q000201:enzymology / Q000254:growth & development; D017346:Protein Serine-Threonine Kinases; D011956:Receptors, Cell Surface / Q000235:genetics* / Q000378:metabolism*
chemical_list: D029681:Arabidopsis Proteins; D011956:Receptors, Cell Surface; C462019:ACR4 protein, Arabidopsis; D017346:Protein Serine-Threonine Kinases