title: Melanocytoma in the orbital apex.
abstract: We report a case of a 49-year-old man presenting with a melanocytoma located in the orbital apex. The tumor was subtotally removed and adjuvant chemotherapy was given. The patient has remained under follow-up for the past 12 years without any evidence of recurrence. Although the characteristic neuroradiological images of the lesion prove the presence of melanin, histological examination is crucial to establish the diagnosis of melanocytoma. Besides the clinical and neuroradiological presentation, the histological, immunohistochemical, and ultrastructural findings are described. To our knowledge, this is the second published case of intraorbital melanocytoma initially confined to the orbital apex. Melanocytoma should be included in the differential diagnosis of intraorbital tumors in such a location.
authors.affiliation: Division of Neurosurgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Science, University of Fukui, 23 Shimoaizuki, Matsuoka, Eiheiji-cho,Yoshida-gun, 910-1193, Fukui, Japan. ksato@u-fukui.ac.jp
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Sato
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Kubota
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Kodera
authors.forename: Ryuhei
authors.initials: R
authors.lastname: Kitai
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Takeuchi
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Yoshida
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003606:Dacarbazine / Q000008:administration & dosage; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D016899:Interferon-beta / Q000008:administration & dosage; D008297:Male; D008544:Melanocytes / Q000378:metabolism / Q000473:pathology*; D008545:Melanoma / Q000473:pathology; D008577:Meningeal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D008875:Middle Aged; D019635:Neurosurgical Procedures; D015376:Nimustine / Q000008:administration & dosage; D009918:Orbital Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D014057:Tomography, X-Ray Computed; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D015376:Nimustine; D014750:Vincristine; D016899:Interferon-beta; D003606:Dacarbazine