Estrogen receptor 2 polymorphism and carotid intima-media thickness.
OBJECTIVE
The present study was designed to investigate the effects of estrogen receptor 2 gene (ESR2) rs1256049 polymorphism to carotid artery intima-media thickness (CIMT), as part of the Cardiovascular Risk in Young Finns Study.


RESULTS
The frequencies of ESR2 genotypes G/G, G/A, and A/A were 85.1%, 14.3%, and 0.7%, respectively, in the whole study population (n = 2211). Compared with subjects with genotype GG, those with the A allele had higher mean CIMT (p = 0.004) and maximal CIMT (p = 0.005).


CONCLUSIONS
In a Finnish population, the ESR2 rs1256049 polymorphism A allele is associated with preclinical atherosclerosis in young adulthood. Our results and those of others also suggest that some effects of this genetic variation may be population specific.
Nikkari
Seppo T
ST
Department of Medical Biochemistry, University of Tampere Medical School , Tampere, Finland. seppo.nikkari@uta.fi
Henttonen
Antti
A
Kunnas
Tarja
T
Kähönen
Mika
M
Hutri-Kähönen
Nina
N
Juonala
Markus
M
Marniemi
Jukka
J
Viikari
Jorma
J
Raitakari
Olli T
OT
Lehtimäki
Terho
T
D000328:Adult; D000483:Alleles; D050197:Atherosclerosis / Q000000981:diagnostic imaging / Q000235:genetics; D002339:Carotid Arteries / Q000000981:diagnostic imaging*; D047629:Estrogen Receptor beta / Q000235:genetics*; D005260:Female; D005387:Finland; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D017539:Tunica Intima / Q000000981:diagnostic imaging; D014463:Ultrasonography
D047629:Estrogen Receptor beta