title: Antioxidant C-glucosylxanthones from the leaves of Arrabidaea patellifera.
abstract: Chemical investigation of the methanol extract from the leaves of Arrabidaea patellifera, a Bignoniaceae from Panama, afforded mangiferin, isomangiferin, and six new derivatives (3'-O-p-hydroxybenzoylmangiferin, 3'-O-trans-coumaroylmangiferin, 6'-O-trans-coumaroylmangiferin, 3'-O-trans-cinnamoylmangiferin, 3'-O-trans-caffeoylmangiferin, and 3'-O-benzoylmangiferin). All these compounds had antioxidant and radical-scavenging activities, and four of them were relatively active in vitro against Plasmodium falciparum. The structures were determined by spectrometric and chemical methods, including 1D and 2D NMR experiments and MS analysis.
authors.affiliation: Laboratory of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest-Ansermet 30, CH-1211 Geneva 4, Switzerland.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Martin
authors.forename: Anne-Emmanuelle
authors.initials: AE
authors.lastname: Hay
authors.forename: Delphine
authors.initials: D
authors.lastname: Cressend
authors.forename: Marianne
authors.initials: M
authors.lastname: Reist
authors.forename: Livia
authors.initials: L
authors.lastname: Vivas
authors.forename: Mahabir P
authors.initials: MP
authors.lastname: Gupta
authors.forename: Pierre-Alain
authors.initials: PA
authors.lastname: Carrupt
authors.forename: Kurt
authors.initials: K
authors.lastname: Hostettmann
mesh_terms: D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029402:Bignoniaceae / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010176:Panama; D010851:Picrates / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000962:Antimalarials; D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; D044004:Xanthones; C013592:mangiferin; C061492:isomangiferin; C004931:1,1-diphenyl-2-picrylhydrazyl