Fundus autofluorescence and multiple evanescent white dot syndrome.
OBJECTIVE
To describe fundus autofluorescence (FAF) in a series of patients with multiple evanescent white dot syndrome.


METHODS
Three eyes of three patients with multiple evanescent white dot syndrome were evaluated with indocyanine green angiography and FAF imaging to evaluate the correspondence between FAF and ICG patterns and the nature of the focal hypocyanescent spots evident with ICG.


RESULTS
In the acute phase, all three eyes showed increased autofluorescence area corresponding precisely to the site of the focal hypocyanescent spots seen on ICG but less numerous. After 2 months, mean best-corrected visual acuity improved from 20/38 to 20/20 and FAF and indocyanine green angiography returned to normal pattern.


CONCLUSIONS
FAF is an useful noninvasive diagnostic adjunct to identify multiple evanescent white dot syndrome, suggesting the inflammatory nature of the disease, probably due to perturbation of the photoreceptor-retinal pigment epithelium complex affecting the function of these cells.
Furino
Claudio
C
Dipartimento di Oftalmologia ed Otorinolaringoiatria, Università di Bari, Bari, Italy.
Boscia
Francesco
F
Cardascia
Nicola
N
Alessio
Giovanni
G
Sborgia
Carlo
C
D000208:Acute Disease; D000328:Adult; D004396:Coloring Agents; D005260:Female; D005451:Fluorescein Angiography; D005453:Fluorescence; D005654:Fundus Oculi; D006801:Humans; D007208:Indocyanine Green; D009887:Ophthalmoscopy; D012160:Retina / Q000473:pathology*; D012164:Retinal Diseases / Q000175:diagnosis*; D055213:Retinal Pigment Epithelium / Q000473:pathology*; D013577:Syndrome; D014792:Visual Acuity; D055815:Young Adult
D004396:Coloring Agents; D007208:Indocyanine Green