Fulminant myopericarditis from phenytoin-induced systemic lupus erythematosus.
Myocarditis and pericarditis are identified at autopsy in up to 50% of patients with systemic lupus erythematosus. However, clinical symptoms of heart failure are unusual, occurring in only 5%-7% of patients. Drug-induced lupus is rare and typically causes classic lupus symptoms of rash, fever, pleuritis, renal insufficiency, and arthritis. We present an unusual case of drug-induced lupus from chronic phenytoin use in a man who presented with symptoms of fulminant myopericarditis. To our knowledge, this is the first such case reported in English.
Atwater
Brett D
BD
Division of Cardiovascular Medicine, Department of Internal Medicine, University of Wisconsin Hospitals and Clinics, Madison, WI 53705, USA. bd.atwater@hosp.wisc.edu
Ai
Zhaowei
Z
Wolff
Matthew R
MR
D003287:Contrast Media; D004452:Echocardiography; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000150:complications*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009205:Myocarditis / Q000175:diagnosis / Q000209:etiology*; D010672:Phenytoin / Q000009:adverse effects*
D003287:Contrast Media; D010672:Phenytoin