[Puvll and Xbal gene polymorphisms of estrogen receptor alpha in children and young adults with cancer from north-eastern region of Poland].
Polygene of the pathogenesis of osteoporosis and the number of factors influencing structure and functions of bone tissue challenge researches to further studies. Estrogen receptor alpha (ERalpha) gene polimorphism influences the transduction of the signal to the bone cells.


OBJECTIVE
The study aimed to establish the frequency of occurrence of Pvull and Xbal gene polymorphism of estrogen receptor alpha in a group of children and adolescents from north-eastern Poland with diagnosed and treated cancer.


METHODS
In the study of gene polymorphism a group of 205 children (113 boys) treated in Department of Pediatric Oncology and its' Outpatient Department in Bialystok was compared with a control group of 70 healthy children (38 boys) from the same part of Poland. Gene polymorphism was established using polymerase chain reaction (PCR) and Pvull and Xbal enzymes.


RESULTS
In both groups heterozygots were prevalent (Pp - 49.27% and 51.43% Xx - 53.17% and 48.57%). The most often occurring genotype was px, and the rarest was pX genotype (1.46% in the study group).


CONCLUSIONS
The influence of ERalpha polymorphism should be taken into account among the negative factors influencing the development of osteoporosis, especially in the case of prolonged lack or minimal physical activity.
Anna
Panasiuk
P
Uniwersytet Medyczny w Białymstoku, Klinika Onkologii Dzieciecej Samodzielny Publiczny Dzieciecy Szpital Kliniczny. annapanasiuk@yahoo.pl
Katarzyna
Muszyńska-Rosłan
MR
Maryna
Krawczuk-Rybak
KR
Anna
Galicka
G
Andrzej
Rybak
R
Małgorzata
Sawicka-Zukowska
SZ
D000293:Adolescent; D000328:Adult; D002648:Child; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000235:genetics*; D010011:Osteocytes / Q000378:metabolism; D010024:Osteoporosis / Q000235:genetics*; D011044:Poland; D011110:Polymorphism, Genetic; D015398:Signal Transduction
C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha