title: [Role of the growth hormone-insulin-like growth factor-1-insulin system signaling in aging and longevity: evolutional aspect].
abstract: Growth hormone (GH)/ insulin-like growth factor 1 (IGF-1)/ insulin signaling molecules linked to longevity include DAF-2 and insulin-receptor and their homologues in mammals, and to inactivation of corresponding genes followed by increased life span in nematodes, fruit flies, and mice. It is possible that the life-prolonging effect of calorie restriction is due to decreasing IGF-1 levels. A search of pharmacological modulators of life-span-extending mutations in the GH/IGF-1/insulin signaling pathway and mimetic effects of caloric restriction is a priority directions in the regulation of longevity. Some literature and our own observations suggest that antidiabetic drugs could be promising candidates for both life span extension and prevention of cancer.
authors.forename: V N
authors.initials: VN
authors.lastname: Anisimov
mesh_terms: D000375:Aging / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001645:Biguanides / Q000494:pharmacology; D017173:Caenorhabditis elegans / Q000502:physiology; D013006:Growth Hormone / Q000502:physiology*; D007004:Hypoglycemic Agents / Q000494:pharmacology; D007328:Insulin / Q000502:physiology*; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D008136:Longevity; D051379:Mice; D009374:Neoplasms, Experimental / Q000517:prevention & control; D051381:Rats; D015398:Signal Transduction; D037761:Sirtuins / Q000235:genetics; D013045:Species Specificity
chemical_list: D001645:Biguanides; D007004:Hypoglycemic Agents; D007328:Insulin; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D037761:Sirtuins