[Expression and significance of glypican-3 in colorectal cancer].
OBJECTIVE
To investigate the expression and significance of Glypican-3 in colorectal cancer.


METHODS
Immunohistochemistry was used to detect the expression of Glypican-3 in 200 specimens of colorectal cancer and adjacent non-cancerous tissues resected during operation.


RESULTS
Glypican-3 immunoreactivity was recognized in both the cytoplasm and cellular membrane. The Glypican-3 positive expression rate in the tumor samples was 66.0% (132/200), significantly higher than that in the adjacent nontumor tissues (24%, 48/200, P = 0.019). The Glypican-3 expression rate was significantly correlated with the carcinoma invasion (P = 0.023) and lymph node metastasis (P = 0.015), but not associated with gender, age, tumor size, and differentiation grade (all P > 0.05).


CONCLUSIONS
Over-expression of Glypican-3 may play an important role in the genesis and development of colorectal cancer, and may be used as a new biological parameter in predicting invasion and metastasis of colorectal carcinoma.
Yuan
Dong-Hong
DH
Institute of Gastroenterology, Xijing Hospital of Fourth Military Medical University, Xi'an 710032, China.
Xie
Hua-Hong
HH
Wang
Yan
Y
Meng
Cun-Ying
CY
Yang
Li-Ping
LP
Feng
Yi-Chao
YC
Song
Jiu-Gang
JG
Zou
Xue
X
Wu
Kai-Chun
KC
Liu
Jie
J
D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D053673:Glypicans / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness
D053673:Glypicans