title: Carbonylative cross-coupling of ortho-disubstituted aryl iodides. convenient synthesis of sterically hindered aryl ketones.
abstract: A mild and general protocol for the carbonylative cross-coupling of sterically hindered ortho-disubstituted aryl iodides is reported. Carbonylative Suzuki-Miyaura couplings of a variety of aryl boronic acids provide an array of substituted biaryl ketones in modest to excellent yield. A carbonylative Negishi coupling that utilizes alkynyl nucleophiles is also described.
authors.affiliation: Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, USA.
authors.forename: B Michael
authors.initials: BM
authors.lastname: O'Keefe
authors.forename: Nicholas
authors.initials: N
authors.lastname: Simmons
authors.forename: Stephen F
authors.initials: SF
authors.lastname: Martin
mesh_terms: D000480:Alkynes / Q000737:chemistry; D001897:Boronic Acids / Q000737:chemistry; D007454:Iodides / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D001897:Boronic Acids; D007454:Iodides; D007659:Ketones