Functionalized analogues of an unnatural amino acid that mimics a tripeptide beta-strand.
This paper introduces polar and hydrophobic variants of the unnatural amino acid Hao, which mimics the hydrogen-bonding functionality of one edge of a beta-strand. In these variants, the methyl side chain of Hao is replaced with acidic, basic, and hydrophobic groups. These modifications can impart improved solubility and additional side-chain interactions to peptides containing Hao.
Khasanova
Tatyana V
TV
Department of Chemistry, University of California, Irvine, Irvine, California 92697-2025, USA.
Khakshoor
Omid
O
Nowick
James S
JS
D000596:Amino Acids / Q000737:chemistry* / Q000378:metabolism*; D040761:Biomimetic Materials / Q000737:chemistry* / Q000378:metabolism*; D006860:Hydrogen Bonding; D009842:Oligopeptides / Q000737:chemistry* / Q000378:metabolism; D017510:Protein Folding; D017433:Protein Structure, Secondary; D012995:Solubility
D000596:Amino Acids; D009842:Oligopeptides