title: Flavoring agents present in a dentifrice can modify volatile sulphur compounds (VSCs) formation in morning bad breath.
abstract: This study aimed to evaluate the effects of a flavor-containing dentifrice on the formation of volatile sulphur compounds (VSCs) in morning bad breath. A two-step, blinded, crossover, randomized study was carried out in 50 dental students with a healthy periodontium divided into two experimental groups: flavor-containing dentifrice (test) and non-flavor-containing dentifrice (control). The volunteers received the designated dentifrice and a new toothbrush for a 3 X/day brushing regimen for 2 periods of 30 days. A seven-day washout interval was used between the periods. The assessed parameters were: plaque index (PI), gingival index (GI), organoleptic breath scores (ORG), VSC levels (as measured by a portable sulphide monitor) before (H1) and after (H2) cleaning of the tongue, tongue coating (TC) wet weight and BANA test from TC samples. The intra-group analysis showed a decrease in ORG, from 3 to 2, after 30 days for the test group (p < 0.05). The inter-group analysis showed lower values in ORG, H1 and H2 for the test group (p < 0.05). There was no difference between the amount of TC between groups and the presence of flavor also did not interfere in the BANA results between groups (p > 0.05). These findings suggest that a flavor-containing dentifrice seems to prevent VSCs formation in morning bad breath regardless of the amount of TC in periodontally healthy subjects.
authors.affiliation: Department of Prosthodontics and Periodontics, Piracicaba Dental School, State University of Campinas, Piracicaba, SP, Brazil. daiaperuzzo@yahoo.com.br
authors.forename: Daiane Cristina
authors.initials: DC
authors.lastname: Peruzzo
authors.forename: Sérgio Luis
authors.initials: SL
authors.lastname: Salvador
authors.forename: Antonio Wilson
authors.initials: AW
authors.lastname: Sallum
authors.forename: Getúlio da Rocha
authors.initials: Gda R
authors.lastname: Nogueira-Filho
mesh_terms: D000293:Adolescent; D000328:Adult; D001419:Bacteria / Q000187:drug effects; D018592:Cross-Over Studies; D003773:Dental Plaque / Q000517:prevention & control; D003774:Dental Plaque Index; D003802:Dentifrices / Q000737:chemistry / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005421:Flavoring Agents / Q000627:therapeutic use*; D006209:Halitosis / Q000382:microbiology / Q000517:prevention & control*; D006801:Humans; D008297:Male; D012463:Saliva / Q000382:microbiology; D013457:Sulfur Compounds / Q000032:analysis* / Q000378:metabolism; D014059:Tongue / Q000382:microbiology; D014099:Toothbrushing; D055815:Young Adult
chemical_list: D003802:Dentifrices; D005421:Flavoring Agents; D013457:Sulfur Compounds