title: Radiosurgery for intracranial gliomas.
abstract: Long-term results of radiosurgery for GI to GIV astrocytomas are described. We have treated 172 astrocytoma cases in total, including 25 GI cases, 52 GII cases, 41 GIII cases and 54 GIV astrocytoma cases. There were 81 males and 91 females, with a mean age of 14.8 for GI, 33 for GII, 45.8 for GIII and 52.4 years for GIV. The maximum and marginal doses for GI astrocytomas were significantly lower than those for the other three grades due to their proximity to the optic nerves. GII to GIV tumors were treated with an approximately 30 Gy mean maximum dose and a 15-Gy mean marginal dose. The response rate of GI tumors exceeded 35%, while that of GII was 50%. However, the response rates of GIII and GIV astrocytomas were very low. Likewise, the tumor control rates were very high for GI and GII tumors, and were very low for GIII and GIV tumors. These results suggest differences in tumor infiltration and malignant activity at the periphery, and indicate the high efficacy of radiosurgery as well as its limitations.
authors.affiliation: Department of Neurosurgery, Komaki City Hospital, Komaki, Japan.
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Kida
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yoshimoto
authors.forename: Toshinori
authors.initials: T
authors.lastname: Hasegawa
mesh_terms: D000293:Adolescent; D000328:Adult; D001254:Astrocytoma / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D001932:Brain Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery; D016019:Survival Analysis; D055815:Young Adult