The role of sphingosine-1-phosphate and ceramide-1-phosphate in calcium homeostasis.
During the last several years, sphingolipids have been identified as a source of important signaling molecules. Particularly, the understanding of the distinct biological roles of ceramide, sphingosine-1-phosphate (S1P), ceramide-1-phosphate (C1P) and lyso-sphingomyelin in the regulation of cell growth, death, senescence, adhesion, migration, inflammation, angiogenesis and intracellular trafficking has rapidly expanded. Additional studies have elucidated the biological roles of sphingolipids in maintaining a homeostatic environment in cells, as well as in regulating numerous cellular responses to environmental stimuli. This review focuses on the role of S1P and C1P in maintaining Ca2+ homeostasis. By studying changes in the metabolism of S1P and C1P in pathological conditions, it is hoped that altered sphingolipid-metabolizing enzymes and their metabolites can be used as therapeutic targets.
Hinkovska-Galcheva
Vania
V
University of Michigan Medical School, Department of Pediatrics, Ann Arbor, MI 48109-2200, USA. tzgalch@umich.edu
VanWay
Susan M
SM
Shanley
Thomas P
TP
Kunkel
Robin G
RG
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology; D020013:Calcium Signaling; D002518:Ceramides / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D008246:Lysophospholipids / Q000502:physiology*; D018919:Neovascularization, Physiologic; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000037:antagonists & inhibitors; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000502:physiology; D000099157:Sphingosine Kinase
D002118:Calcium; D015220:Calcium Channels; D002518:Ceramides; D008246:Lysophospholipids; D017853:Phosphotransferases (Alcohol Group Acceptor); D013110:Sphingosine; D000099157:Sphingosine Kinase; C065576:ceramide 1-phosphate; C060506:sphingosine 1-phosphate