title: In situ temperature-jump dynamic nuclear polarization: enhanced sensitivity in two dimensional 13C-13C correlation spectroscopy in solution.
abstract: Dynamic nuclear polarization is combined with temperature-jump methods to develop a new 2D 13C-13C NMR experiment that yields a factor of 100-170 increase in sensitivity. The polaization step is performed at 100 K, and the sample is subsequently melted with a 10.6 microm laser pulse to yield a sample with highly polarized 13C spins. 13C detected 2D 13C-13C spectroscopy is performed in the usual manner.
authors.affiliation: Francis Bitter Magnet Laboratory and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Chan-Gyu
authors.initials: CG
authors.lastname: Joo
authors.forename: Andrew
authors.initials: A
authors.lastname: Casey
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Turner
authors.forename: Robert G
authors.initials: RG
authors.lastname: Griffin
mesh_terms: D002247:Carbon Isotopes; D017666:Deuterium Oxide / Q000737:chemistry; D005947:Glucose / Q000032:analysis* / Q000737:chemistry; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D012680:Sensitivity and Specificity; D012996:Solutions; D013696:Temperature; D014867:Water / Q000737:chemistry
chemical_list: D002247:Carbon Isotopes; D012996:Solutions; D014867:Water; D005947:Glucose; D017666:Deuterium Oxide