Estimated glomerular filtration rate for drug dose adjustment: Cockcroft and Gault or abbreviated MDRD equation?
OBJECTIVE
Evaluate if Cockcroft and Gault (CG) estimated glomerular filtration rate (eGFR) might be replaced by abbreviated MDRD eGFR for drug dose adjustment.


METHODS
eGFR was determined in 140 hospitalized patients (median: 68 years, 65 kg) treated by nephrotoxic and/or renally cleared drugs.


RESULTS
CG eGFR was 61 mL/min vs. 78 mL/min/1.73 m(2) for MDRD (p<0.0001). CG-MDRD difference ranged from -93 to +34 mL/min, influenced by patient age, weight, and gender (p<0.001).


CONCLUSIONS
CG eGFR cannot be easily replaced by abbreviated MDRD eGFR for drug dose adjustment.
Roblin
Isabelle
I
Pharmacy Department, Valence Hospital, 26000 Valence, France. iroblin@ch-valence.fr
De Sobarnitsky
Sophie
S
Basselin
Cécile
C
Vial
Fabienne
F
Bard
Emmanuel
E
Dufrene
Isabelle
I
Hida
Hassan
H
Laurencin
Christian
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D008875:Middle Aged
D003404:Creatinine