New perspectives for the treatment options in spinal cord injury.
Spinal cord injury (SCI) is a serious clinical disorder that leads to lifetime disability for which no suitable therapeutic agents are available so far. Further research is needed to understand the basic mechanisms of spinal cord pathology that results in permanent disability and poses a heavy burden on our society. In the past, a lot of effort was placed on improving functional outcome with the help of various therapeutic agents, however less attention has been paid on the development and propagation of spinal cord pathology over time. Thus, it is still unclear whether improvement of functional outcome is related to spinal cord pathology or vice versa. Few drugs are able to influence functional outcome without having any improvement on cord pathology. Some drugs, however, can lessen cord pathology but fail to influence the functional outcome. The goal of future treatment options for SCI is therefore to find suitable new drugs or a combination of existing drugs and to use various cellular transplants, neurotrophic factors, myelin-inhibiting factors, tissue engineering and nano-drug delivery to improve both the functional and the pathological outcome in the inured patient. This review deals with the key aspects of the latest treatments for SCI and suggests some possible future therapeutic measures to enhance healthcare in clinical situations.
Sharma
Hari Shanker
HS
Uppsala University, University Hospital, Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anaesthesiology & Intensive Care Medicine, SE-75185 Uppsala, Sweden. sharma@surgsci.uu.se
D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism; D004195:Disease Models, Animal; D004594:Electrophysiology; D006801:Humans; D018696:Neuroprotective Agents / Q000627:therapeutic use; D013119:Spinal Cord Injuries / Q000378:metabolism / Q000473:pathology / Q000601:surgery / Q000628:therapy*
D018696:Neuroprotective Agents