[Gene expression difference analysis between abdominal aorta aneurysm and normal abdominal artery].
OBJECTIVE
To identify gene expression differences between abdominal aorta aneurysm (AAA) and normal abdominal artery.


METHODS
Five AAA specimens and five normal abdominal artery specimens were collected. Total RNA was extracted and purified from the samples independently. Then isolated RNA was labeled and hybridized onto the Affymetrix Genechip.


RESULTS
One thousand nine hundreds and sixty-two differently expressed genes were identified in AAA compared with normal abdominal artery, of which 554 genes were up-regulated and 1408 genes were down-regulated. Functional analysis revealed that genes involved in immune response, inflammatory response and chemokines were significantly up-regulated in AAA.


CONCLUSIONS
The differently expressed genes may be useful in providing new insights and foster a better understanding of the mechanism of AAA.
Zhao
Hai-Guang
HG
Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011, China.
Fu
Shi-Jun
SJ
Jiang
Mi-Er
ME
D001012:Aorta, Abdominal / Q000378:metabolism; D017544:Aortic Aneurysm, Abdominal / Q000235:genetics*; D020869:Gene Expression Profiling; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis