title: [Hyperreactive malarial splenomegaly: three clinical cases and literature review].
abstract: Hyperreactive malarial splenomegaly (HMS) is the chronic stage of a long-term stimulation of the immune system secondary to plasmodial infections, more frequently in genetically predisposed patients. HMS is a leading cause of large tropical splenomegaly in endemic zones but has been described in immigrants from Africa and in some European expatriates living in endemic countries. Diagnostic criteria include: long-term stay in a endemic zone, often large splenomegaly, high IgM titer, high antiplasmodial antibody titer, regression by at least 40% of splenomegaly six months after curative antimalarial treatment. In tropical settings, B-cell lymphoma and splenic lymphoma are the main differential diagnoses, which may be identified by a clonality analysis. Recent studies suggest that HMS can be treated by a short-term antimalarial therapy as long as the patient resides out of a malarial endemic country.
authors.affiliation: Service de maladies infectieuses et tropicales, hôpital Purpan, 1, place Baylac, 31059 Toulouse, cedex 9, France.
authors.forename: B
authors.initials: B
authors.lastname: Camara
authors.forename: J-B
authors.initials: JB
authors.lastname: Kantambadouno
authors.forename: G
authors.initials: G
authors.lastname: Martin-Blondel
authors.forename: A
authors.initials: A
authors.lastname: Berry
authors.forename: M
authors.initials: M
authors.lastname: Alvarez
authors.forename: F
authors.initials: F
authors.lastname: Benoit-Vical
authors.forename: J
authors.initials: J
authors.lastname: Delmont
authors.forename: O
authors.initials: O
authors.lastname: Bouchaud
authors.forename: B
authors.initials: B
authors.lastname: Marchou
mesh_terms: D000293:Adolescent; D000328:Adult; D000349:Africa; D000368:Aged; D000818:Animals; D016535:Bronchial Hyperreactivity / Q000276:immunology; D003937:Diagnosis, Differential; D054242:Emigrants and Immigrants; D005060:Europe; D005260:Female; D006801:Humans; D008288:Malaria / Q000276:immunology*; D008297:Male; D010963:Plasmodium falciparum / Q000302:isolation & purification; D013163:Splenomegaly / Q000209:etiology* / Q000276:immunology* / Q000469:parasitology