Formin' an invasion machine: actin polymerization in invading apicomplexans.
Apicomplexan parasites are motile and invade host cells. The force required for this is generated by an actomyosin motor. In a recent paper, Baum and colleagues suggest that the protein formin regulates the polymerization of actin at the moving junction between parasite and host cell. This finding provides novel insight into the mechanism of host cell invasion.
Holder
Anthony A
AA
Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK. aholder@nimr.mrc.ac.uk
Veigel
Claudia
C
D000199:Actins / Q000378:metabolism*; D000205:Actomyosin / Q000378:metabolism; D000818:Animals; D016782:Apicomplexa / Q000166:cytology* / Q000502:physiology*
D000199:Actins; D000205:Actomyosin