title: Parallel synthesis of a multi-substituted benzo[b]furan library.
abstract: The solution-phase parallel synthesis of a 121-member library of multi-substituted benzo[ b]furans is described. 2,3,5-Trisubstituted benzo[ b]furans have been prepared by the palladium-catalyzed substitution of 3-iodobenzofurans by Suzuki-Miyaura, carbonylative Suzuki, Sonogashira, Heck, and carboalkoxylation chemistry. The 3-iodobenzofurans are readily prepared in good to excellent yields by the palladium/copper-catalyzed cross-coupling of various o-iodoanisoles and terminal alkynes, followed by electrophilic cyclization with ICl.
authors.affiliation: Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA.
authors.forename: Chul-Hee
authors.initials: CH
authors.lastname: Cho
authors.forename: Benjamin
authors.initials: B
authors.lastname: Neuenswander
authors.forename: Gerald H
authors.initials: GH
authors.lastname: Lushington
authors.forename: Richard C
authors.initials: RC
authors.lastname: Larock
mesh_terms: D000480:Alkynes; D000840:Anisoles; D001572:Benzofurans / Q000138:chemical synthesis*; D020650:Combinatorial Chemistry Techniques; D007455:Iodine; D010165:Palladium; D054852:Small Molecule Libraries / Q000138:chemical synthesis*
chemical_list: D000480:Alkynes; D000840:Anisoles; D001572:Benzofurans; D054852:Small Molecule Libraries; D010165:Palladium; D007455:Iodine