title: Correlation between body weight (epididymal fat) and permeation rate of serum leptin through the blood-brain barrier (BBB) in male rats aged 8 months.
abstract: In this study, in order to clarify the kinetics of leptin, we focused on the ratio of leptin concentrations in cerebrospinal fluid and serum in aged male rats, and examined the weight of epididymal fat, and the passage rate of leptin through the blood-brain barrier. In the lighter animals, the epididymal fat weight was low, while leptin concentrations in the serum and cerebrospinal fluid were also low. Conversely, in the heavier animals, the weight of epididymal fat and leptin concentrations in the serum and cerebrospinal fluid were higher. With regard to the ratio of leptin in the cerebrospinal fluid and serum, the passage rate of leptin through the blood-brain barrier was lower in the heavier animals than in the lighter animals.
authors.affiliation: Behavioral Neuroscience Section, Nippon Veterinary and Life Science University, Tokyo, Japan.
authors.forename: Mitsuro
authors.initials: M
authors.lastname: Suzuki
authors.forename: Qing
authors.initials: Q
authors.lastname: Ding
authors.forename: Shiro
authors.initials: S
authors.lastname: Muranaka
authors.forename: Megumi
authors.initials: M
authors.lastname: Kigure
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kojima
authors.forename: Misao
authors.initials: M
authors.lastname: Terada
authors.forename: Noyuri
authors.initials: N
authors.lastname: Kataoka
authors.forename: Akiko
authors.initials: A
authors.lastname: Hagiwara
authors.forename: Pudcharaporn
authors.initials: P
authors.lastname: Kromkhun
authors.forename: Naoki
authors.initials: N
authors.lastname: Moritani
authors.forename: Haruo
authors.initials: H
authors.lastname: Hashimoto
authors.forename: Makoto
authors.initials: M
authors.lastname: Yokosuka
authors.forename: Fujiro
authors.initials: F
authors.lastname: Sakurai
authors.forename: Minoru
authors.initials: M
authors.lastname: Tanaka
authors.forename: Toru R
authors.initials: TR
authors.lastname: Saito
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology*; D000375:Aging; D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology*; D001835:Body Weight; D004822:Epididymis / Q000033:anatomy & histology*; D020738:Leptin / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D008297:Male; D051381:Rats
chemical_list: D020738:Leptin