Antidiabetic activity of aqueous extract and non polysaccharide fraction of Cynodon dactylon Pers.
Petroleum ether (60 degrees-80 degrees C), chloroform, acetone, ethanol, aqueous and crude hot water extracts of the whole plant of C. dactylon and the two fractions of aqueous extract were tested for antihyperglycaemic activity in glucose overloaded hyperglycemic rats and in alloxan induced diabetic model at two-dose levels, 200 and 400 mg/kg (po) respectively. The aqueous extract of C. dactylon and the non polysaccharide fraction of aqueous extract were found to exhibit significant antihyperglycaemic activity and only the non polysaccharide fraction was found to produce hypoglycemia in fasted normal rats. Treatment of diabetic rats with aqueous extract and non polysaccharide fraction of the plant decreased the elevated biochemical parameters, glucose, urea, creatinine, serum cholesterol, serum triglyceride, high density lipoprotein, low density lipoprotein, haemoglobin and glycosylated haemoglobin significantly. Comparatively, the non polysaccharide fraction of aqueous extract was found to be more effective than the aqueous extract.
Jarald
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Department of Herbal Drug Research, B.R. Nahata College of Pharmacy and Research Centre, Mhow Neemuch Road, Mandsaur 458 001, India. jaraldpharm@rediffmail.com
Joshi
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Jain
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D000496:Alloxan / Q000494:pharmacology; D000818:Animals; D031744:Cynodon / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D005215:Fasting; D005260:Female; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008297:Male; D010777:Photochemistry; D010936:Plant Extracts / Q000737:chemistry* / Q000627:therapeutic use*; D011134:Polysaccharides / Q000302:isolation & purification; D051381:Rats; D017208:Rats, Wistar
D007004:Hypoglycemic Agents; D010936:Plant Extracts; D011134:Polysaccharides; D000496:Alloxan