Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder.
A time-to-onset analysis for family-based samples was performed on the genomewide association (GWAS) data for attention deficit hyperactivity disorder (ADHD) to determine if associations exist with the age at onset of ADHD. The initial dataset consisted of 958 parent-offspring trios that were genotyped on the Perlegen 600,000 SNP array. After data cleaning procedures, 429,981 autosomal SNPs and 930 parent-offspring trios were used found suitable for use and a family-based logrank analysis was performed using that age at first ADHD symptoms as the quantitative trait of interest. No SNP achieved genome-wide significance, and the lowest P-values had a magnitude of 10(-7). Several SNPs among a pre-specified list of candidate genes had nominal associations including SLC9A9, DRD1, ADRB2, SLC6A3, NFIL3, ADRB1, SYT1, HTR2A, ARRB2, and CHRNA4. Of these findings SLC9A9 stood out as a promising candidate, with nominally significant SNPs in six distinct regions of the gene.
Lasky-Su
Jessica
J
Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Anney
Richard J L
RJ
Neale
Benjamin M
BM
Franke
Barbara
B
Zhou
Kaixin
K
Maller
Julian B
JB
Vasquez
Alejandro Arias
AA
Chen
Wai
W
Asherson
Philip
P
Buitelaar
Jan
J
Banaschewski
Tobias
T
Ebstein
Richard
R
Gill
Michael
M
Miranda
Ana
A
Mulas
Fernando
F
Oades
Robert D
RD
Roeyers
Herbert
H
Rothenberger
Aribert
A
Sergeant
Joseph
J
Sonuga-Barke
Edmund
E
Steinhausen
Hans Christoph
HC
Taylor
Eric
E
Daly
Mark
M
Laird
Nan
N
Lange
Christoph
C
Faraone
Stephen V
SV
D000293:Adolescent; D017668:Age of Onset; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D055106:Genome-Wide Association Study; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide; D011336:Probability; D040641:Quantitative Trait Loci; D012189:Retrospective Studies; D017923:Sodium-Hydrogen Exchangers / Q000235:genetics
D005819:Genetic Markers; C478541:SLC9A9 protein, human; D017923:Sodium-Hydrogen Exchangers