Low basal levels of circulating adiponectin in patients undergoing coronary stenting predict in-stent restenosis, independently of basal levels of inflammatory markers: lipoprotein associated phospholipase A2, and myeloperoxidase.
OBJECTIVE
The aim of this study was to find a pre-interventional marker with the capacity to predict in-stent restenosis (ISR). Considering the anti-atherosclerotic role of adiponectin (APO), an adipocytokine with anti-inflammatory, anti-proliferative, anti-oxidative and anti-thrombotic properties, low plasma levels of APO might be correlated with the risk of ISR. We investigated the correlations between the plasma levels of APO and two markers of inflammation: lipoprotein associated phospholipase A2 (Lp-PLA2) and myeloperoxidase (MPO).


METHODS
80 patients with angiographically significant stenosis underwent percutaneous coronary intervention (PCI) with bare metal stent. Plasma APO concentration and plasma Lp-PLA2 and MPO activities were evaluated immediately before and after PCI, then followed-up at 24, 48, 72 h, and at 1, 3, 6 months, respectively. ISR was evaluated at 6 months after stenting by follow-up coronary angiograms, and it was defined as >50% stenosis of the target lesion.


RESULTS
ISR was present in 33.75% of patients. Baseline APO plasma concentration, measured before PCI, was lower in ISR patients than those without ISR [3.97 (+/-1.05) vs 6.65 (+/-2.95) microg/mL respectively, p<0.001]. The patients with APO values less than 4.9 microg/mL at discharge were more susceptible to develop ISR (odd ratio, 4.27; 95% CI, 1.56-11.72, p<0.001). ISR rate was independent of inflammation markers Lp-PLA2 and MPO baseline values, measured before PCI.


CONCLUSIONS
The persistence of a low APO plasma level at discharge and 6 months afterwards may be used as a clinically useful marker for ISR prediction in patients undergoing PCI.
Moldoveanu
Elena
E
Victor Babes National Institute of Pathology and Biomedical Research, Bucharest, Romania. Emoldoveanu@hotmail.com
Mut-Vitcu
Bogdan
B
Tanaseanu
George R
GR
Marta
Daciana S
DS
Manea
Gabriela
G
Kosaka
Tetsuya
T
Vidulescu
Cristina
C
Tanaseanu
Cristina
C
D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000097:blood*; D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D015415:Biomarkers / Q000097:blood*; D023903:Coronary Restenosis / Q000097:blood*; D006801:Humans; D007249:Inflammation / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000097:blood*; D012372:ROC Curve; D012680:Sensitivity and Specificity; D015607:Stents
D052242:Adiponectin; D015415:Biomarkers; D009195:Peroxidase; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase