Increased elevated plus maze open-arm time in mice during spontaneous morphine withdrawal.
Rats undergoing both naloxone-precipitated and spontaneous opioid withdrawal exhibit anxiogenic behaviors in the elevated plus maze (EPM). Recently, we observed an unexpected result, namely mice exhibited increased EPM open-arm time during naloxone-precipitated morphine withdrawal. This was surprising since this behavioral outcome is usually associated with an anxiolytic profile. This study demonstrates that mice exhibit an increase in both EPM open-arm time and % open-arm entries also during spontaneous opioid withdrawal.
Buckman
Sam G
SG
Behavioral and Cellular Neuroscience, Department of Psychology, Texas A&M University, College Station, TX 77843 United States.
Hodgson
Stephen R
SR
Hofford
Rebecca S
RS
Eitan
Shoshana
S
D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D001007:Anxiety / Q000503:physiopathology / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects* / Q000502:physiology; D007279:Injections, Subcutaneous; D008297:Male; D018782:Maze Learning / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology*; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology* / Q000523:psychology
D000701:Analgesics, Opioid; D009020:Morphine