title: Mite-control activities of active constituents isolated from Pelargonium graveolens against house dust mites.
abstract: The mite-control activities of materials obtained from Pelargonium graveolens oil against Dermatophagoides farinae and D. pteronyssinus were examined using an impregnated fabric disk bioassay and were compared with those shown by commercial benzyl benzoate and N,N-diethylm- toluamide (DEET). Purification of the biologically active constituents from P. graveolens oil was done by silica gel chromatography and high performance liquid chromatography. The structures of the active components were analyzed by EI/MS, (1)H-NMR, (13)C-NMR, (1)H-(13)C COSYNMR, and DEPT-NMR spectra, and were identified as geraniol (C(10)H(18)O, MW 154.25, trans-3,7-dimethyl-2,6- octadien-1-ol) and beta-citronellol (C(10)H(20)O, MW 156.27, 3,7-dimethyl-6-octen-1-ol). Based on the LD50 values, the most toxic compound was geraniol (0.26 microg/cm(2)), followed by beta-citronellol (0.28 microg/cm(2)), benzyl benzoate (10.03 microg/ cm(2)), and DEET (37.12 microg/cm(2)) against D. farinae. In the case of D. pteronyssinus, geraniol (0.28 microg/cm(2)) was the most toxic, followed by beta-citronellol (0.29 microg/cm(2)), benzyl benzoate (9.58 microg/cm(2)), and DEET (18.23 microg/cm(2)). These results suggest that D. farinae and D. pteronyssinus may be controlled more effectively by the application of geraniol and beta-citronellol than benzyl benzoate and DEET. Furthermore, geraniol and beta-citronellol isolated from P. graveolens could be useful for managing populations of D. farinae and D. pteronyssinus.
authors.affiliation: Bioenviornmental Science Major and Institute of Agricultural Science and Technology, College of Agriculture & Life Science,Chonbuk National University, Chonju 561-756, Korea.
authors.forename: Ju-Hyun
authors.initials: JH
authors.lastname: Jeon
authors.forename: Hyung-Wook
authors.initials: HW
authors.lastname: Kim
authors.forename: Min-Gi
authors.initials: MG
authors.lastname: Kim
authors.forename: Hoi-Seon
authors.initials: HS
authors.lastname: Lee
mesh_terms: D000080462:Acyclic Monoterpenes; D000818:Animals; D001565:Benzoates / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D006145:Guanethidine / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D009930:Organic Chemicals / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D031316:Pelargonium / Q000737:chemistry*; D010938:Plant Oils / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D039981:Pyroglyphidae / Q000187:drug effects*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D013983:Tick Control
chemical_list: D000080462:Acyclic Monoterpenes; D001565:Benzoates; D007306:Insecticides; D039821:Monoterpenes; D009930:Organic Chemicals; D010938:Plant Oils; D013729:Terpenes; C007836:geraniol; C006723:benzyl benzoate; C007078:citronellol; D006145:Guanethidine