Persistent Mullerian duct syndrome in a Miniature Schnauzer dog with signs of feminization and a Sertoli cell tumour.
A 5-year-old male Miniature Schnauzer was presented with unilateral cryptorchidism and signs of feminization. Abdominal ultrasonography revealed an enlarged right testis and a large, fluid-filled cavity that appeared to arise from the prostate. Computed tomography revealed the cavity to be consistent with an enlarged uterine body, arising from the prostate, and showed two structures resembling uterine horns that terminated close to the adjacent testes. The dog had a normal male karyotype, 78 XY. Gonadohysterectomy was performed and both the surgical and the histological findings confirmed the presence of a uterus in this male animal, resulting in a diagnosis of persistent Mullerian duct syndrome (PMDS). The enlarged intra-abdominal testis contained a Sertoli cell tumour. Computed tomography proved to be an excellent diagnostic tool for PMDS.
Vegter
A R
AR
Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Kooistra
H S
HS
van Sluijs
F J
FJ
van Bruggen
L W L
LW
Ijzer
J
J
Zijlstra
C
C
Okkens
A C
AC
D000818:Animals; D003456:Cryptorchidism / Q000473:pathology / Q000662:veterinary; D012734:Disorders of Sex Development / Q000175:diagnosis / Q000601:surgery / Q000662:veterinary; D004283:Dog Diseases / Q000175:diagnosis* / Q000235:genetics; D004285:Dogs; D005260:Female; D005262:Feminization / Q000175:diagnosis / Q000662:veterinary*; D007621:Karyotyping / Q000662:veterinary; D008297:Male; D009095:Mullerian Ducts; D012707:Sertoli Cell Tumor / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D013737:Testis / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography / Q000662:veterinary; D014599:Uterus / Q000473:pathology / Q000601:surgery