title: Clinical implementation of a new HDR brachytherapy device for partial breast irradiation.
abstract: OBJECTIVE
  To present the clinical implementation of a new HDR device for partial breast irradiation, the Strut-Adjusted Volume Implant (SAVI), at the University of California, San Diego.
  
  
  METHODS
  The SAVI device has multiple peripheral struts that can be differentially loaded with the HDR source. Planning criteria used for evaluation of the treatment plans included the following dose volume histogram (DVH) criteria: V90 >90%, V150 <50cc and V200 <20cc.
  
  
  RESULTS
  SAVI has been used on 20 patients to date at UC San Diego. In each case, the dose was modulated according to patient-specific anatomy to cover the tumor bed, while sparing normal tissues. The dosimetric data show that we can achieve greater than 90% coverage with respect to V90 (median of 95.3%) and also keep a low V150 and V200 dose at 24.5 and 11.2cc, respectively. Complete treatment can be done within a 30-min time slot, which includes implant verification, setup, and irradiation time as well as wound dressing.
  
  
  CONCLUSIONS
  SAVI has been implemented at UC San Diego for accelerated partial breast irradiation with excellent tumor bed conformance and minimal normal tissue exposure. Patient positioning is the key to identifying any inter-fraction device motion. Device asymmetry or tissue conformance has been shown to resolve itself 24h after the device implantation. The device can be implemented into an existing HDR program with minimal effort.
authors.affiliation: Department of Radiation Oncology, UC San Diego, La Jolla, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Scanderbeg
authors.forename: Catheryn
authors.initials: C
authors.lastname: Yashar
authors.forename: Roger
authors.initials: R
authors.lastname: Rice
authors.forename: Todd
authors.initials: T
authors.lastname: Pawlicki
mesh_terms: D001918:Brachytherapy / Q000295:instrumentation*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy* / Q000601:surgery; D003131:Combined Modality Therapy; D019583:Dose Fractionation, Radiation; D004867:Equipment Design; D005260:Female; D006801:Humans; D015641:Radiography, Interventional; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome