title: Current state for the development of metallopharmaceutics and anti-diabetic metal complexes.
abstract: This tutorial review introduces the current state of metallopharmaceutics development by focusing on the topics of anti-diabetic vanadium and zinc complexes. Over thousands of years, people have produced many types of inorganic compounds, and the modern concept of chemotherapy was achieved by Ehrlich, who used an arsenic-containing compound to treat syphilis. Since then, many metallopharmaceutics have been developed worldwide. This review will be helpful to researchers who are interested in the current states of not only metallopharmaceutics but also anti-diabetic metal complexes.
authors.affiliation: Department of Physical Pharmaceutical Science, Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Mie, Japan. sakuraih@suzuka-u.ac.jp
authors.forename: Hiromu
authors.initials: H
authors.lastname: Sakurai
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yoshikawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yasui
mesh_terms: D000818:Animals; D001153:Arsphenamine / Q000737:chemistry; D002945:Cisplatin / Q000737:chemistry; D049669:History, 16th Century; D049672:History, 19th Century; D049673:History, 20th Century; D049690:History, Ancient; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000266:history / Q000378:metabolism / Q000494:pharmacology; D008670:Metals / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000266:history / Q000378:metabolism; D014639:Vanadium / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity; D017967:Zinc Compounds / Q000378:metabolism / Q000633:toxicity
chemical_list: D007004:Hypoglycemic Agents; D008670:Metals; D004364:Pharmaceutical Preparations; D017967:Zinc Compounds; D014639:Vanadium; D001153:Arsphenamine; D002945:Cisplatin