The first cyclic monomeric 3-alkylpyridinium alkaloid from natural sources: identification, synthesis, and biological activity.
3-Alkylpyridine alkaloids are very common secondary metabolites from marine sponges of the order Haplosclerida. Here, we report on the identification and synthesis of the first cyclic monomeric 3-alkylpyridinium alkaloid from natural sources. Due to the lack of a pure sample of the new compound, structure elucidation had to rely on HPLC and MS(n).
Timm
Christoph
C
Alfred-Wegener-Institut für Polar- und Meeresforschung in der Helmholtz-Gemeinschaft, Am Handelshafen 12, D-27570, Bremerhaven, Germany.
Volk
Christian
C
Sasse
Florenz
F
Köck
Matthias
M
D000470:Alkaloids / Q000737:chemistry*; D000818:Animals; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D047129:Haliclona / Q000737:chemistry*; D051379:Mice; D011726:Pyridinium Compounds / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D013211:Staphylococcus aureus / Q000187:drug effects
D000470:Alkaloids; D011726:Pyridinium Compounds