[Effective CDDP arterial infusion with DSM for liver metastasis of malignant melanoma complicating DIC due to intratumoral hemorrhage--a case report].
A 65-year-old male, who had been diagnosed with melanoma of stage IIB and treated by chemotherapy since 2003 at the Dermatology Department, was referred to our department for liver metastasis of melanoma that had become resistant to chemotherapeutic agents. In 2006, he started receiving hepatic arterial infusion of CDDP. He was admitted to the hospital on an emergency basis for general fatigue the next May. Blood tests revealed anemia and thrombocytopenia. Contrast CT showed aggravation of liver metastasis. Contrast ultrasonography revealed nodular contrast enhancement at the margin of the tumor. On the basis of image findings and blood test results, DIC due to intratumoral hemorrhage was diagnosed. CDDP arterial infusion with DSM resulted in improved DIC, and he was able to be discharged. Taken together, attention has to be paid to the potential for emergency complications of DIC due to liver metastasis of melanoma with intratumoral hemorrhage. Moreover, it was shown that arterial infusion with DSM was effective for liver metastasis of melanoma.
Takada
Kohichi
K
Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine.
Kato
Junji
J
Kawano
Yutaka
Y
Takahashi
Sho
S
Hayashi
Tsuyoshi
T
Ishiwatari
Hirotoshi
H
Miyanishi
Koji
K
Takimoto
Rishu
R
Kobune
Masayoshi
M
Sagawa
Tamotsu
T
Sato
Tsutomu
T
Sato
Yasushi
Y
Yamashita
Toshiharu
T
Natori
Hiroshi
H
Niitsu
Yoshiro
Y
D000368:Aged; D002543:Cerebral Hemorrhage / Q000188:drug therapy / Q000209:etiology*; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy* / Q000209:etiology*; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D008545:Melanoma / Q000150:complications* / Q000188:drug therapy*; D008863:Microspheres; D013213:Starch; D017211:Treatment Failure
D013213:Starch; D002945:Cisplatin