Combining microchip and cell technology for creation of novel biodevices.
Microchip technology has matured over the years into an important field in which novel technologies are being constantly invented, and down-sizing and incorporation of already existing methodologies into the microscale is increasing assay performance and bearing the promise of future total integration for simple, widespread use. One rapidly growing sub-discipline of the microchip research field is focused around the integration of microchip technology and cell biology. In this review, we recapitulate progress here at the Kitamori laboratory in direct relation to cell and microchip technologies, and show some examples of successful integration of the two, going from controlled patterning of cells, on-chip cell culture stimulation, and cardiovascular systems on a chip, to bio-microdevices integrating cardiovascular cells and microtechnology to create novel biodevices such as biocompatible, miniature pumps.
Sato
Kae
K
Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1, Hongo, Bunkyo, Tokyo, 113-8656, Japan.
Tanaka
Yo
Y
Renberg
Björn
B
Kitamori
Takehiko
T
D002448:Cell Adhesion; D018929:Cell Culture Techniques / Q000295:instrumentation*; D006801:Humans; D046228:Microarray Analysis / Q000295:instrumentation*