Metal complexes of natural melophlins and their cytotoxic and antibiotic activities.
Complexes of the natural melophlins A and C with Mg, Zn, Ga, La and Ru were prepared, characterized and tested for antimicrobial and cytotoxic effects. The lanthanum complex La(melophlinato C)(3) and the ruthenium complex chlorido(eta(6)-p-cymene)(melophlinato C)ruthenium(II) inhibited cells of human A-498 kidney cancer at IC(50)=0.54 microM and 1.0 microM, respectively, and so distinctly better than free melophlin C. Another synergistic effect of coordinating melophlins to bioactive metals was found in the growth inhibition of the melophlin C-resistant bacterium Micrococcus luteus by Ga, La and Ru complexes of melophlin C.
Biersack
Bernhard
B
Organic Chemistry Laboratory, University of Bayreuth, Universitätsstrasse 30, 95440 Bayreuth, Germany.
Diestel
Randi
R
Jagusch
Carsten
C
Sasse
Florenz
F
Schobert
Rainer
R
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D015195:Drug Design; D006801:Humans; D008670:Metals / Q000737:chemistry*; D016982:Micrococcus luteus / Q000187:drug effects; D009942:Organometallic Compounds / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry*; D011760:Pyrrolidinones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D008670:Metals; D009942:Organometallic Compounds; D011759:Pyrrolidines; D011760:Pyrrolidinones; C009435:tetramic acid