Nandrolone decanoate increases the volume but not the length of the proximal and distal convoluted tubules of the mouse kidney.
Anabolic androgenic steroids are widely used by athletes for increasing their muscle mass. These drugs are also used by some patients with chronic renal disease. But the effect of these drugs on the renal structure has received less attention. To investigate which parts of the kidney are affected by these drugs, mice kidneys were studied stereologically after injection of nandrolone decanoate (ND), an anabolic androgenic steroid. The treated group received nandrolone decanoate intraperitoneally (solved in olive oil) in doses of 3mg/kg of body weight and administered in one, two and three doses, respectively, in the first, second and third week of treatment. The mice in the control group received an olive oil solution. One week after the last injection, the mice were anaesthetized and their kidney removed. The analysis of data revealed that the weight of kidney was increased approximately 30% (p < or = 0.006) and its volume increased approximately 25% (p < or = 0.02) in ND treated mice in comparison with the control group. The volume of the cortex increased in ND treated animals approximately 44% (p < or = 0.006). Proximal convoluted tubules (PCT) and distal convoluted tubules (DCT) volume increased approximately 25% (p < or = 0.02) and approximately 68% (p < or = 0.02) in ND treated mice. The volume of glomeruli, other ducts, connective tissues, vessels and the length of PCT, DCT, collecting and Henle's ducts and vessels did not show significant differences.


CONCLUSIONS
ND can increase the volume of the renal cortex and its two main parts, i.e. PCT and DCT in mice.
Hoseini
Leila
L
Internal Medicine Department, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Roozbeh
Jamshid
J
Sagheb
Mehdi
M
Karbalay-Doust
Saied
S
Noorafshan
Ali
A
D045930:Anabolic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000648:ultrastructure; D007686:Kidney Tubules, Distal / Q000187:drug effects* / Q000648:ultrastructure*; D007687:Kidney Tubules, Proximal / Q000187:drug effects* / Q000648:ultrastructure*; D051379:Mice; D018715:Microscopy, Video; D009277:Nandrolone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D000077603:Nandrolone Decanoate; D010780:Photogrammetry
D045930:Anabolic Agents; D009277:Nandrolone; D000077603:Nandrolone Decanoate