title: Anaplasma phagocytophilum transmitted through blood transfusion--Minnesota, 2007.
abstract: Anaplasma phagocytophilum, a gram-negative, obligate intracellular bacterium of neutrophils, causes human anaplasmosis, a tickborne rickettsial disease formerly known as human granulocytic ehrlichiosis. In November 2007, the Minnesota Department of Health was contacted about A. phagocytophilum infection in a hospitalized Minnesota resident who had recently undergone multiple blood transfusions. Subsequent investigation indicated the infection likely was acquired through a transfusion of red blood cells. This report describes the patient's clinical history and the epidemiologic and laboratory investigations. Although a previous case of transfusion-transmitted anaplasmosis was reported, this is the first published report in which transfusion transmission of A. phagocytophilum was confirmed by testing of the recipient and a donor. Although polymerase chain reaction (PCR) assays provided reliable evidence of transmission in this case, no cost-effective method for screening blood donors for A. phagocytophilum exists. Screening donors for a recent history of tick bite is not likely to be sensitive or specific because such exposures are common and often not recalled by persons with anaplasmosis. Physicians should consider the possibility of anaplasmosis in patients who develop posttransfusion acute thrombocytopenia, especially if accompanied by fever, and should report suspected transfusion-associated cases to health authorities.
mesh_terms: D000368:Aged; D041081:Anaplasma phagocytophilum / Q000235:genetics / Q000276:immunology; D000907:Antibodies, Bacterial / Q000097:blood; D019645:Arthroplasty, Replacement, Knee; D001782:Blood Donors; D004269:DNA, Bacterial / Q000032:analysis; D004318:Doxycycline / Q000627:therapeutic use; D016873:Ehrlichiosis / Q000150:complications / Q000188:drug therapy / Q000635:transmission*; D017707:Erythrocyte Transfusion / Q000009:adverse effects*; D005260:Female; D005334:Fever / Q000209:etiology; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D008297:Male; D008875:Middle Aged; D008910:Minnesota; D016133:Polymerase Chain Reaction; D013921:Thrombocytopenia / Q000209:etiology*
chemical_list: D000907:Antibodies, Bacterial; D004269:DNA, Bacterial; D004318:Doxycycline