title: [Heart failure and cachexia].
abstract: Cachexia is related to a malnutrition state related to hypercatabolism. Initially described in cancer, it is also related to several chronic diseases including heart failure. Defined by an unintentional weight loss exceeding 7.5% of body mass during more than 6 months, it is presented by the association of nutritional deficiencies, digestive and/or urinary losses as well as metabolic abnormalities causing fat and lean mass loss and is associated to a poor prognosis. The pathophysiology of cachexia and heart failure presented some similarities associating especially neuro-hormonal activation, a cortisol/DHEA ratio imbalance, as well as pro-inflammatory cytokines activation. Currently the treatment of cachexia is mainly preventive, based on ACE-inhibitors and beta-blockers therapy and physical reconditioning. The benefits of hormonal and nutritional substitutes remains to be evidenced.
authors.affiliation: Centre de réadaption cardiaque des Grands Près 27, rue Sainte-Christine, Villeneuve-Saint-Denis. jtabet@free.fr
authors.forename: J Y
authors.initials: JY
authors.lastname: Tabet
authors.forename: P
authors.initials: P
authors.lastname: Meurin
authors.forename: A
authors.initials: A
authors.lastname: Ben Driss
authors.forename: D
authors.initials: D
authors.lastname: Logeart
authors.forename: C
authors.initials: C
authors.lastname: Héliès-Toussaint
authors.forename: J M
authors.initials: JM
authors.lastname: Tartière
authors.forename: A
authors.initials: A
authors.lastname: Cohen-Solal
authors.forename: A
authors.initials: A
authors.lastname: Grynberg
authors.forename: I
authors.initials: I
authors.lastname: Bourdel-Marchasson
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D002100:Cachexia / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D016207:Cytokines / Q000502:physiology; D006333:Heart Failure / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D008991:Monitoring, Physiologic; D009748:Nutrition Disorders / Q000209:etiology; D012084:Renin-Angiotensin System / Q000502:physiology; D015431:Weight Loss
chemical_list: D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D016207:Cytokines