title: [Recurrent multiple cranial nerve palsy in a gravida with type 1 diabetes, that remitted after delivery and with steroid therapy].
abstract: We report a rare case of multiple cranial nerve palsy associated with pregnancy, the cause of which remained to be clarified despite of extensive inspections. A 28-year-old woman with type 1 diabetes on insulin therapy developed left oculomotor nerve palsy in the fourth month of pregnancy. Her symptoms improved after one month's administration of vitamins B1 and B12. Numbness appeared in the left side of the face in the 8th month of pregnancy, and then moved to the right side in two weeks. Dysarthria and dysphagia occurred one month later. Bulbar symptoms were worsened, and she became unable to eat or drink. Neurological examination revealed disturbance of sensation in the right side of the face, soft palate paresis, and bilateral atrophy and fasciculation of the tongue. Extensive laboratory examinations including immunological and endocrinological studies, cerebrospinal fluid examination and brain magnetic resonance imaging were unremarkable. These symptoms remitted spontaneously after delivery, and the methylprednisolone pulse therapy accelerated the improvement. Neurological examination done one year after delivery showed complete recovery of the symptoms except for persistent tongue atrophy.
authors.affiliation: Department of Neurology, Mie University Graduate School of Medicine.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Shindo
authors.forename: Akira
authors.initials: A
authors.lastname: Taniguchi
authors.forename: Chisako
authors.initials: C
authors.lastname: Nakano
authors.forename: Ryogen
authors.initials: R
authors.lastname: Sasaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Sugiyama
authors.forename: Shigeki
authors.initials: S
authors.lastname: Kuzuhara
mesh_terms: D000328:Adult; D003389:Cranial Nerve Diseases / Q000209:etiology*; D036861:Delivery, Obstetric; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D005260:Female; D006801:Humans; D011239:Prednisolone / Q000008:administration & dosage*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology*; D011254:Pregnancy in Diabetics; D020551:Pulse Therapy, Drug; D012008:Recurrence
chemical_list: D011239:Prednisolone