Lipid Lowering Activity of Anthocephalus indicus Root in Hyperlipidemic Rats.
The lipid lowering activity of Anthocephalus indicus (family Rubiaceae; Hindi name Kadamba) root extract has been studied in triton WR-1339 induced hyperlipidemia in rats. In this model, feeding with root extract (500 mg kg(-1) b.w.) lowered plasma lipids and reactivated post-heparin lipolytic activity in hyperlipidemic rats. Furthermore, the root extract (50-500 μM) inhibited the generation of superoxide anions and hydroxyl radicals, in both enzymic and non-enzymic systems, in vitro. The results of the present study demonstrated both lipid lowering and antioxidant activities in root extract of A. indicus, which could help prevention of hyperlipidemia and related diseases.
Kumar
Vishnu
V
Department of Biochemistry, Era's Lucknow Medical College & Hospital, Lucknow-226003, Division of Biochemistry, Central Drug Research Institute, Lucknow-226001 and Department of Biochemistry, King George's Medical University, Lucknow-226003, India.
Khan
Mohammad Mubin
MM
Khanna
Ashok Kumar
AK
Singh
Ranjana
R
Singh
Sushma
S
Chander
Ramesh
R
Mahdi
Farzana
F
Mahdi
Abbas Ali
AA
Saxena
Jitendra Kumar
JK
Singh
Raj Kumar
RK