Anti-P ribosomal antibodies induce defect in smell capability in a model of CNS -SLE (depression).
Systemic lupus erythematosus (SLE) is an autoimmune disease associated with more than 100 different autoantibodies, some of which may be associated with specific neuropsychiatric (NPSLE) manifestations. Injection of anti-P ribosomal antibodies (anti-P) directly to the brain ventricles of mice induces depression manifested by increased immobility time in the forced swim test (FST).


METHODS
Mice were injected intracerebroventricularily (ICV) with affinity-purified human anti-P antibodies or normal commercial IgG as control. Mice were examined for depression by the forced swimming test (FST) and for olfactory function by the smell threshold test. Treatments included the antidepressant drug fluoxetine or aroma therapy by exposure to lemon or cinnamon odor.


RESULTS
Mice injected with anti-P developed depression-like behavior, which improved significantly upon treatment with fluoxetine. Depressed mice had a significant deficit in olfactory function which was not reversed by fluoxetine. Exposure of anti-P-injected mice to lemon odor was associated with some improvement of the immobility time, a measure of depression.


CONCLUSIONS
ICV injection of anti-P induces both depression-like behavior and impaired olfactory function in mice. Fluoxetine and possibly lemon odor exposure improve depressive behavior in these mice.
Katzav
Aviva
A
Department of Neurology, Sagol Neuroscience Center, Sheba Medical Center, Tel-Hashomer, Israel.
Ben-Ziv
Tal
T
Chapman
Joab
J
Blank
Miri
M
Reichlin
Morris
M
Shoenfeld
Yehuda
Y
D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology; D001323:Autoantibodies / Q000276:immunology*; D002552:Cerebral Ventricles / Q000187:drug effects / Q000276:immunology; D003863:Depression / Q000209:etiology / Q000276:immunology*; D004195:Disease Models, Animal; D005260:Female; D005473:Fluoxetine / Q000494:pharmacology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000276:immunology*; D051379:Mice; D008809:Mice, Inbred C3H; D009812:Odorants; D000857:Olfaction Disorders / Q000209:etiology / Q000276:immunology*; D055696:Olfactory Perception / Q000276:immunology; D012269:Ribosomal Proteins / Q000276:immunology*
D018687:Antidepressive Agents, Second-Generation; D001323:Autoantibodies; D012269:Ribosomal Proteins; D005473:Fluoxetine