[The clinical features and prognosis of drug-induced liver disease].
OBJECTIVE
To analyse the etiology, clinical features and prognosis of drug-induced liver disease (DILD), in order to draw more attention to this problem.


METHODS
332 cases of DILD admitted to the First Affiliated Hospital of Zhejiang University from 2000-2006 were retrospectively analysed.


RESULTS
A variety of drugs, including herbal medicines (27.1% of our total cases), anti-tuberculosis drugs (13.3%) and immunosuppressive drugs (10.8%) caused drug-induced liver damage. The hepatocellular type (43.1%) was the most common type seen clinically and the mixed type (32.5%) and cholestatic type (24.4%) were somewhat less.


CONCLUSIONS
A variety of medicines may cause DILD; herbal medicines, anti-tuberculosis drugs and immunosuppressive drugs were frequently found to be responsible, the hepatocellular type was the most common, while the mixed type and cholestatic type were somewhat less. Serum albumin, total bile acids, direct bilirubin and blood prothrombin time are important predictors of the prognosis of DILD.
Wang
Xiao-Li
XL
Department of Gastroenterology, the First Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310003, China.
Yu
Zhao-Hui
ZH
Chen
Shao-Hua
SH
Li
You-Ming
YM
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000410:Alanine Transaminase / Q000097:blood; D000428:Alcohol Drinking; D000469:Alkaline Phosphatase / Q000097:blood; D001647:Bile Acids and Salts / Q000097:blood; D001663:Bilirubin / Q000097:blood; D002648:Child; D064420:Drug-Related Side Effects and Adverse Reactions / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012709:Serum Albumin / Q000032:analysis; D055815:Young Adult
D001647:Bile Acids and Salts; D012709:Serum Albumin; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin