Cerebral sinus venous thrombosis in a subject with thyrotoxicosis and MTHFR gene polymorphism.
We report a case of cerebral venous thrombosis (CVT) due to tyrotoxicosis in a patient with methylenetetrahydro-folate-reductase (MTHFR) gene polymorphism C677T, (genotype 677TT), in which discontinuation of intravenous heparin was followed by clinical and radiological worsening despite warfarin treatment. We discuss the relationship between CVT, MTHFR hyperthiroidism and anticoagulant therapy.
Strada
Laura
L
Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Via De Toni 5, Genoa, Italy. mdelsette@neurologia.unige.it
Gandolfo
Carlo
C
Del Sette
Massimo
M
D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D011110:Polymorphism, Genetic; D012851:Sinus Thrombosis, Intracranial / Q000188:drug therapy / Q000209:etiology* / Q000235:genetics*; D013971:Thyrotoxicosis / Q000150:complications* / Q000235:genetics; D014859:Warfarin / Q000627:therapeutic use
D000925:Anticoagulants; D014859:Warfarin; D006493:Heparin; D042965:Methylenetetrahydrofolate Reductase (NADPH2)