title: Reduction of Delta2-isoxazolines to beta-hydroxy ketones with iron and ammonium chloride as reducing agent.
abstract: A detailed study of a procedure for the selective reduction of Delta(2)-isoxazolines to the corresponding beta-hydroxy ketones is reported. The use of iron and ammonium chloride as the reducing agent in the presence of water results in a facile and chemoselective protocol for the preparation of beta-hydroxy ketones, including the conjugated beta-hydroxy ketones.
authors.affiliation: Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, PR China.
authors.forename: Dahong
authors.initials: D
authors.lastname: Jiang
authors.forename: Yuanwei
authors.initials: Y
authors.lastname: Chen
mesh_terms: D000643:Ammonium Chloride / Q000737:chemistry*; D007501:Iron / Q000737:chemistry*; D007555:Isoxazoles / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D010084:Oxidation-Reduction; D019163:Reducing Agents / Q000737:chemistry*; D013379:Substrate Specificity
chemical_list: D007555:Isoxazoles; D007659:Ketones; D019163:Reducing Agents; D000643:Ammonium Chloride; D007501:Iron