title: Efficacy assessment and complications of surgical management for superior semicircular canal dehiscence: a meta-analysis of published interventional studies.
abstract: Superior semicircular canal syndrome (SSCS) includes vestibular and audiological symptoms which result from the introduction of a third mobile window into the osseous cochlea. Surgical repair is considered in cases of incapacitating symptoms. The present paper aims at comparing the different surgical approaches and modes of dehiscence repair, regarding their respective efficacy and potential pitfalls. A systematic literature review and meta-analysis of pooled data were performed. Study selection included prospective- and retrospective-controlled studies, prospective- and retrospective-cohort studies, ex vivo studies, animal models, case-reports, systematic reviews and clinical guidelines. A total of 64 primary operations for SSC repair were identified; 56 ears were operated for vestibular and 7 for auditory complaints. A total of 33 ears underwent canal plugging, 16 resurfacing, and 15 capping. Success rates were 32/33, 8/16, and 14/15, respectively. The observed differences were statistically significant (P=0.001). Resurfacing proved less effective than both plugging (P=0.002), and capping (P=0.01) techniques. Temporalis fascia was commonly used as sealing material and was combined with bone-pâté/bone-wax (plugging), bone-graft (resurfacing), or hydroxyapatite-cement (capping). Most operations were performed via middle-fossa approach; higher success rates were associated with plugging and capping techniques. SNHL and disequilibrium were the most frequent complications encountered. Most cases were followed for 3-6 months. Precise criteria regarding follow-up duration and objective success measures are not determined. Surgical repair of SSCS is considered as a valid therapeutic option for patients with debilitating symptoms. Consensus regarding strict follow-up criteria and objective assessment of success is necessary before larger scale operations can be implemented in clinical practice.
authors.affiliation: ENT Department, Hippokrateion General Hospital of Athens, 114 Vas. Sofias Av., 11527 Athens, Greece. pevlast@hotmail.com
authors.forename: Petros V
authors.initials: PV
authors.lastname: Vlastarakos
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Proikas
authors.forename: Evangelia
authors.initials: E
authors.lastname: Tavoulari
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Kikidis
authors.forename: Paul
authors.initials: P
authors.lastname: Maragoudakis
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Nikolopoulos
mesh_terms: D000818:Animals; D001301:Audiometry, Pure-Tone; D004195:Disease Models, Animal; D005260:Female; D005500:Follow-Up Studies; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis / Q000209:etiology / Q000601:surgery; D006801:Humans; D007759:Labyrinth Diseases / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D008297:Male; D013506:Otologic Surgical Procedures / Q000009:adverse effects* / Q000379:methods; D016032:Randomized Controlled Trials as Topic; D012086:Reoperation; D018570:Risk Assessment; D012665:Semicircular Canals / Q000503:physiopathology / Q000601:surgery*; D012720:Severity of Illness Index; D013529:Surgical Wound Dehiscence / Q000601:surgery*; D013577:Syndrome; D016896:Treatment Outcome; D015837:Vestibular Diseases / Q000150:complications / Q000175:diagnosis / Q000601:surgery