IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels.
The IUPHAR database (IUPHAR-DB) integrates peer-reviewed pharmacological, chemical, genetic, functional and anatomical information on the 354 nonsensory G protein-coupled receptors (GPCRs), 71 ligand-gated ion channel subunits and 141 voltage-gated-like ion channel subunits encoded by the human, rat and mouse genomes. These genes represent the targets of approximately one-third of currently approved drugs and are a major focus of drug discovery and development programs in the pharmaceutical industry. IUPHAR-DB provides a comprehensive description of the genes and their functions, with information on protein structure and interactions, ligands, expression patterns, signaling mechanisms, functional assays and biologically important receptor variants (e.g. single nucleotide polymorphisms and splice variants). In addition, the phenotypes resulting from altered gene expression (e.g. in genetically altered animals or in human genetic disorders) are described. The content of the database is peer reviewed by members of the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR); the data are provided through manual curation of the primary literature by a network of over 60 subcommittees of NC-IUPHAR. Links to other bioinformatics resources, such as NCBI, Uniprot, HGNC and the rat and mouse genome databases are provided. IUPHAR-DB is freely available at http://www.iuphar-db.org.
Harmar
Anthony J
AJ
Centres for Cardiovascular Science and Neuroscience Research, The Queen's Medical Research Institute, Institute of Evolutionary Biology, Ashworth Labs, School of Informatics, University of Edinburgh, Edinburgh, UK. tony.harmar@ed.ac.uk
Hills
Rebecca A
RA
Rosser
Edward M
EM
Jones
Martin
M
Buneman
O Peter
OP
Dunbar
Donald R
DR
Greenhill
Stuart D
SD
Hale
Valerie A
VA
Sharman
Joanna L
JL
Bonner
Tom I
TI
Catterall
William A
WA
Davenport
Anthony P
AP
Delagrange
Philippe
P
Dollery
Colin T
CT
Foord
Steven M
SM
Gutman
George A
GA
Laudet
Vincent
V
Neubig
Richard R
RR
Ohlstein
Eliot H
EH
Olsen
Richard W
RW
Peters
John
J
Pin
Jean-Philippe
JP
Ruffolo
Robert R
RR
Searls
David B
DB
Wright
Mathew W
MW
Spedding
Michael
M
D000818:Animals; D030562:Databases, Protein; D055808:Drug Discovery; D006801:Humans; D007473:Ion Channels / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*; D008024:Ligands; D051379:Mice; D021122:Protein Subunits / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D051381:Rats; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*
D007473:Ion Channels; D008024:Ligands; D021122:Protein Subunits; D043562:Receptors, G-Protein-Coupled