The HIF-1 alpha-C/EBP alpha axis.
The hypoxia inducible factors (HIFs) and CCAAT/enhancer binding protein alpha (C/EBP alpha) are transcription factors that mediate adaptive responses to hypoxia and control aspects of energy metabolism, respectively. New evidence suggests that when HIF-1 alpha and C/EBP alpha interact, they bring about reciprocal functional changes, so that the activity of HIF-1 alpha is decreased and that of C/EBP alpha is restricted or increased in a tissue-specific manner. This Journal Club article highlights research depicting interactions between HIF-1 alpha and C/EBP alpha and discusses conditions and tissues in which this interaction might occur.
Janardhan
Harish P
HP
Department of Biochemistry, Christian Medical College, Vellore, India. harishpj@cmcvellore.ac.in
D000818:Animals; D022763:CCAAT-Enhancer-Binding Protein-alpha / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D000860:Hypoxia; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding / Q000502:physiology; D014157:Transcription Factors
D022763:CCAAT-Enhancer-Binding Protein-alpha; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D014157:Transcription Factors