In vivo assessment of novel furosemide gastro-mucoadhesive delivery system based on a kind of anion ion-exchange fiber.
A novel gastro-mucoadhesive delivery system based on a kind of anion ion-exchange fiber has been developed. Furosemide (FM), which is site-specifically absorbed from the upper gastrointestinal (GI) tract, was used as model drug. A novel-modified dissolution system, which can also be called "flow through diffusion cell," was used to study the drug release from the drug fibers. The GI transit studies of the FM fiber complexes in rats and gamma imaging studies in volunteers were carried out to evaluate the gastro-mucoadhesive behavior of the fiber. The pharmacokinetic profile and parameters of the FM suspension and FM fiber in fasted and fed rats were measured, respectively. Studies on rats and volunteers provided evidence for the validity of the hypothesis that the drug fiber provided better gastro-mucoadhesive properties in vivo.
Yao
Huimin
H
School of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang, The People's Republic of China.
Wang
Shujun
S
Sun
Yundong
Y
Liu
Hongzhuo
H
Li
Sanming
S
D000269:Adhesives; D000818:Animals; D001682:Biological Availability; D004232:Diuretics / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D005665:Furosemide / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005753:Gastric Mucosa / Q000000981:diagnostic imaging / Q000378:metabolism*; D006801:Humans; D007413:Intestinal Mucosa / Q000000981:diagnostic imaging / Q000378:metabolism; D007421:Intestine, Small / Q000000981:diagnostic imaging / Q000378:metabolism; D007474:Ion Exchange; D008297:Male; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D051381:Rats; D017208:Rats, Wistar; D012996:Solutions; D013667:Technetium
D000269:Adhesives; D004232:Diuretics; D019275:Radiopharmaceuticals; D012996:Solutions; D013667:Technetium; D005665:Furosemide