title: Polybrominated diphenyl ethers and polychlorinated biphenyls in human breast adipose samples from Brazil.
abstract: Twenty five human breast adipose tissue samples were collected in Porto Alegre, Brazil during 2004-2005 and analyzed for polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs). SigmaPBDE concentrations (sum of tri- to hepta-BDEs) ranged from 0.19 to 132 ng/g lipid with a median of 1.51 ng/g lipid. These concentrations are 3- to 100-times lower than those reported from other countries, with the exception of Japan, probably reflecting lower usage of PBDE-containing products or lower exposures to these chemicals. The predominant congener was BDE-47, followed by BDEs 99, 183, 153 and 100. One individual in the dataset had about 70-times higher PBDE concentrations than the rest of the participants. SigmaPCB (sum of PCBs 118, 138, 153, 180) ranged from 30 to 339 ng/g lipid, with a median of 51 ng/g lipid. No age dependency was found for PBDEs (r=-0.800-0.374, p>0.05) or PCB 180 (r=0.278, p>0.05). On the other hand, PCBs 118, 138 and 153 did show age dependency (r=0.410-0.458, p<0.05). This is the first study to report levels of PBDEs in human breast adipose from Brazil.
authors.affiliation: Department of Toxic Substances Control, Environmental Chemistry Laboratory, 700 Heinz Avenue, Suite 100, Berkeley CA, 94710, USA. kalantzi@aegean.gr
authors.forename: O I
authors.initials: OI
authors.lastname: Kalantzi
authors.forename: F R
authors.initials: FR
authors.lastname: Brown
authors.forename: M
authors.initials: M
authors.lastname: Caleffi
authors.forename: R
authors.initials: R
authors.lastname: Goth-Goldstein
authors.forename: M
authors.initials: M
authors.lastname: Petreas
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry*; D000367:Age Factors; D001938:Brazil; D001940:Breast / Q000737:chemistry*; D005260:Female; D055768:Halogenated Diphenyl Ethers / Q000032:analysis*; D006801:Humans; D011078:Polychlorinated Biphenyls / Q000032:analysis*
chemical_list: D055768:Halogenated Diphenyl Ethers; D011078:Polychlorinated Biphenyls