title: Candida bloodstream infection: data from a teaching hospital in Mato Grosso do Sul, Brazil.
abstract: The incidence of Candida bloodstream infection has increased over the past years. In the Center-West region of Brazil, data on candidemia are scarce. This paper reports a retrospective analysis of 96 cases of Candida bloodstream infection at a Brazilian tertiary-care teaching hospital in the state of Mato Grosso do Sul, from January 1998 to December 2006. Demographic, clinical and laboratory data were collected from medical records and from the hospital's laboratory database. Patients' ages ranged from three days to 92 years, with 53 (55.2%) adults and 43 (44.8%) children. Of the latter, 25 (58.1%) were newborns. The risk conditions most often found were: long period of hospitalization, utilization of venous central catheter, and previous use of antibiotics. Fifty-eight (60.4%) patients died during the hospitalization period and eight (13.7%) of them died 30 days after the diagnosis of candidemia. Candida albicans (45.8%) was the most prevalent species, followed by C. parapsilosis (34.4%), C. tropicalis (14.6%) and C. glabrata (5.2%). This is the first report of Candida bloodstream infection in the state of Mato Grosso do Sul and it highlights the importance of considering the possibility of invasive Candida infection in patients exposed to risk factors, particularly among neonates and the elderly.
authors.affiliation: Department of Pharmacy-Biochemistry, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil. marirchang@yahoo.com.br
authors.forename: Marilene Rodrigues
authors.initials: MR
authors.lastname: Chang
authors.forename: Flávia Patussi
authors.initials: FP
authors.lastname: Correia
authors.forename: Leonora Correa
authors.initials: LC
authors.lastname: Costa
authors.forename: Paula Cristhina Niz
authors.initials: PC
authors.lastname: Xavier
authors.forename: Durval Batista
authors.initials: DB
authors.lastname: Palhares
authors.forename: Deborah Ledesma
authors.initials: DL
authors.lastname: Taira
authors.forename: Anamaria Mello Miranda
authors.initials: AM
authors.lastname: Paniago
authors.forename: Elenir Rose Jardim Cury
authors.initials: ER
authors.lastname: Pontes
authors.forename: Vanessa Escobar
authors.initials: VE
authors.lastname: Machado
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil / Q000453:epidemiology; D002175:Candida / Q000145:classification* / Q000302:isolation & purification; D002177:Candidiasis / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D002648:Child; D002675:Child, Preschool; D005260:Female; D016469:Fungemia / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D006784:Hospitals, Teaching; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult