Predicting progressive glaucomatous optic neuropathy using baseline standard automated perimetry data.
OBJECTIVE
To test the hypothesis that specific locations and patterns of threshold findings within the visual field have predictive value for progressive glaucomatous optic neuropathy (pGON).


METHODS
Age-adjusted standard automated perimetry thresholds, along with other clinical variables gathered at the initial examination of 168 individuals with high-risk ocular hypertension or early glaucoma, were used as predictors in a classification tree model. The classification variable was a determination of pGON, based on longitudinally gathered stereo optic nerve head photographs. Only data for the worse eye of each individual were included. Data from 100 normal subjects were used to test the specificity of the models.


RESULTS
Classification tree models suggest that patterns of baseline visual field findings are predictive of pGON with sensitivity 65% and specificity 87% on average. Average specificity when data from normal subjects were run on the models was 69%.


CONCLUSIONS
Classification trees can be used to determine which visual field locations are most predictive of poorer prognosis for pGON. Spatial patterns within the visual field convey useable predictive information, in most cases when thresholds are still well within the classically defined normal range.
Demirel
Shaban
S
Devers Eye Institute, Legacy Health System, Portland, Oregon 97232, USA. sdemirel@deverseye.org
Fortune
Brad
B
Fan
Juanjuan
J
Levine
Richard A
RA
Torres
Rodrigo
R
Nguyen
Hau
H
Mansberger
Steven L
SL
Gardiner
Stuart K
SK
Cioffi
George A
GA
Johnson
Chris A
CA
D018450:Disease Progression; D005189:False Positive Reactions; D005260:Female; D005901:Glaucoma / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000175:diagnosis / Q000503:physiopathology; D009901:Optic Nerve Diseases / Q000175:diagnosis* / Q000503:physiopathology; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D014065:Tonometry, Ocular; D058609:Visual Field Tests / Q000379:methods*; D014794:Visual Fields / Q000502:physiology