New acylides: synthesis of 3-O-[gamma-(4-oxo-2-aryl-thiazolidin-3-yl)butyryl]erythromycin A derivatives.
In search of new erythromycin derivatives 3-O-[gamma-(4-oxo-2-aryl-thiazolidin-3-yl)butyryl]erythromycin A derivatives have been synthesized. The 3-hydroxy group was derivatised to a primary amine and subsequently the thiazolidinone nucleus was generated at the amino functionality through DCC mediated one-pot three-component reaction in good yields.
Pandey
Deepa
D
Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow, 226 001 India. pandeydeepa1@yahoo.com
Haq
Wahajul
W
Katti
Seturam B
SB