title: Identification of novel acetylenic alcohols and a new dihydrothiopyranone from the tropical sponge Reniochalina sp.
abstract: Two new acetylenic alcohols (1-2) and a new dihydrothiopyranone (3) were isolated from the tropical sponge Reniochalina sp. Their structures were determined by spectroscopic and chemical methods to be (3R)-hydroxyoctatriacont-(4E)-en-1-yne (1), 5-hydroxyheptatriacont-(3Z)-en-1-yne (2) and 2-hexadecyl-2,3-dihydrothiopyran-4-one (3). The acetylenic alcohol (1) exhibited significant growth inhibitory effect against human tumor cell lines.
authors.affiliation: Korea Ocean Research & Development Institute, Ansan, 426-744, South Korea.
authors.forename: Hyi-Seung
authors.initials: HS
authors.lastname: Lee
authors.forename: Ji Hye
authors.initials: JH
authors.lastname: Lee
authors.forename: Hoshik
authors.initials: H
authors.lastname: Won
authors.forename: Song-Kyu
authors.initials: SK
authors.lastname: Park
authors.forename: Hwan Mook
authors.initials: HM
authors.lastname: Kim
authors.forename: Hee Jae
authors.initials: HJ
authors.lastname: Shin
authors.forename: Heung Sik
authors.initials: HS
authors.lastname: Park
authors.forename: Chung J
authors.initials: CJ
authors.lastname: Sim
authors.forename: Hye-Kyeong
authors.initials: HK
authors.lastname: Kim
mesh_terms: D000107:Acetylation; D000438:Alcohols / Q000737:chemistry*; D000818:Animals; D006859:Hydrogen / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011161:Porifera / Q000737:chemistry*; D011714:Pyrans / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D000438:Alcohols; D011714:Pyrans; D013438:Sulfhydryl Compounds; C522033:thiopyran; D006859:Hydrogen