title: One-pot approach for the synthesis of trans-cyclopropyl compounds from aldehydes. Application to the synthesis of GPR40 receptor agonists.
abstract: A novel multicatalytic one-pot process providing trans-cyclopropyl compounds from corresponding aldehydes has been developed and applied to the synthesis of GPR40 small molecule agonists.
authors.affiliation: Département de Chimie, Université de Montréal, 2900 Boul. Edouard Montpetit, Montréal, Québec, Canada H3T 1J4.
authors.forename: Michaël
authors.initials: M
authors.lastname: Davi
authors.forename: Hélène
authors.initials: H
authors.lastname: Lebel
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry; D002384:Catalysis; D003521:Cyclopropanes / Q000138:chemical synthesis* / Q000737:chemistry; D043562:Receptors, G-Protein-Coupled / Q000819:agonists*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000475:Alkenes; D003521:Cyclopropanes; D043562:Receptors, G-Protein-Coupled; C030797:cyclopropane