title: [The Incidence of occupational asthma in Alsace from 2001 to 2002. Results of intensification of the ONAP project in Alsace (2001-2002). Regional specificities].
abstract: BACKGROUND
  A national surveillance programme (ONAP project) was created in France in 1996 by two professional societies to estimate the incidence and identity the characteristics of occupational asthma.
  
  
  METHODS
  In 2001 and 2002 chest physicians and occupational physicians in Alsace were intensively solicited for better voluntary reporting of cases of occupational asthma. The objective of this study was to evaluate the consequences of such a procedure on the number of cases reported, with a view to collecting comprehensive data.
  
  
  RESULTS
  The mean annual incidence of occupational asthma was estimated at 126 cases per million workers with a female predominance (52.4%). Flours and isocyanates represented 40% of the suspected agents. Isocyanate asthma (21% of the total) was reported mainly in workers in the car supply industry, and seems to be a specific feature of the region. Persulfates represented 5.3% of the cases; latex and aldehydes 2.6%. The study also points to emergent aetiologies and work risks, i.e. quaternary ammonium compounds in disinfecting detergent products used by cleaners and healthcare workers.
  
  
  CONCLUSIONS
  This study, which allowed better assessment of the real incidence of OA in Alsace and better detection of substances and occupations at risk, is an incentive to continue our Surveillance programme.
authors.affiliation: Service de Pneumologie, Hôpital Lyautey, Hôpitaux Universitaires de Strasbourg, France.
authors.forename: E
authors.initials: E
authors.lastname: Popin
authors.forename: M-C
authors.initials: MC
authors.lastname: Kopferschmitt-Kubler
authors.forename: M
authors.initials: M
authors.lastname: Gonzalez
authors.forename: M
authors.initials: M
authors.lastname: Brom
authors.forename: F
authors.initials: F
authors.lastname: Flesch
authors.forename: G
authors.initials: G
authors.lastname: Pauli
mesh_terms: D000328:Adult; D001249:Asthma / Q000139:chemically induced / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D017953:Isocyanates / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D009790:Occupations; D011159:Population Surveillance; D012042:Registries; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D017953:Isocyanates