title: A model of the olivo-cerebellar system as a temporal pattern generator.
abstract: The olivo-cerebellar system has been implicated in temporal coordination of task components. Here, we propose a novel model that enables the olivo-cerebellar system to function as a generator of temporal patterns. These patterns could be used for timing of motor, sensory and cognitive tasks. The proposed mechanism for the generation of these patterns is based on subthreshold oscillations in a network of inferior olivary neurons and their control by the cerebellar cortex and nuclei. Our model, which integrates a large body of anatomical and physiological observations, lends itself to simple, testable predictions and provides a new conceptual framework for olivo-cerebellar research.
authors.affiliation: Department of Neurobiology, Life Science Institute and the Interdisciplinary Centre for Neural Computation, Hebrew University, Jerusalem 91904, Israel.
authors.forename: Gilad A
authors.initials: GA
authors.lastname: Jacobson
authors.forename: Dan
authors.initials: D
authors.lastname: Rokni
authors.forename: Yosef
authors.initials: Y
authors.lastname: Yarom
mesh_terms: D000818:Animals; D002531:Cerebellum / Q000502:physiology*; D006801:Humans; D008959:Models, Neurological; D009434:Neural Pathways; D009847:Olivary Nucleus / Q000502:physiology*