title: Nitric oxide bioavailability and its potential relevance to the variation in susceptibility to the renal and vascular complications in patients with type 2 diabetes.
abstract: OBJECTIVE
  We compared the renal and systemic vascular (renovascular) response to a reduction of bioavailable nitric oxide (NO) in type 2 diabetic patients without nephropathy and of African and Caucasian heritage.
  
  
  METHODS
  Under euglycemic conditions, renal blood flow was determined by a constant infusion of paraminohippurate and changes in blood pressure and renal vascular resistance estimated before and after an infusion of L-Ng-monomethyl-L-arginine.
  
  
  RESULTS
  In the African-heritage group, there was a significant fall in renal blood flow (Delta-46.0 ml/min per 1.73 m(2); P < 0.05) and rise in systolic blood pressure (Delta 10.0 mmHg [95% CI 2.3-17.9]; P = 0.017), which correlated with an increase in renal vascular resistance (r(2) = 0.77; P = 0.004).
  
  
  CONCLUSIONS
  The renal vasoconstrictive response associated with NO synthase inhibition in this study may be of relevance to the observed vulnerability to renal injury in patients of African heritage.
authors.affiliation: University College London Medical School, Whittington Hospital, London, UK. k.earle@sgul.ac.uk
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Earle
authors.forename: Diane
authors.initials: D
authors.lastname: Harry
authors.forename: Mitra
authors.initials: M
authors.lastname: Madhavi
authors.forename: Karima
authors.initials: K
authors.lastname: Zitouni
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Barron
mesh_terms: D000328:Adult; D017668:Age of Onset; D001682:Biological Availability; D044383:Black People / Q000706:statistics & numerical data; D001794:Blood Pressure; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000453:epidemiology*; D003928:Diabetic Nephropathies / Q000453:epidemiology*; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000493:pharmacokinetics*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D012079:Renal Circulation; D044465:White People / Q000706:statistics & numerical data
chemical_list: D009569:Nitric Oxide; D019001:Nitric Oxide Synthase