title: Diagnosis and treatment of pulmonary arterial hypertension and atrial fibrillation in an adult chimpanzee (Pan troglodytes).
abstract: This report describes the diagnosis and treatment of pulmonary arterial hypertension (PAH) in an adult male captive chimpanzee. Although cardiovascular disease in general is common in human and great apes, diagnosis and treatment of PAH in nonhuman primates are uncommon. In the case we present, the adult chimpanzee was diagnosed with an arrhythmia during an annual physical examination and later with PAH during a scheduled cardiovascular evaluation. PAH can either be primary or secondary and can lead to right ventricular overload and heart failure. This description is the first case study of pulmonary arterial hypertension in a great ape species.
authors.affiliation: Alomogordo Primate Research Faculty, Holloman Air Base, Alomogordo, NM, USA. michael.lammey@crl.com
authors.forename: Michael L
authors.initials: ML
authors.lastname: Lammey
authors.forename: Cynthia J
authors.initials: CJ
authors.lastname: Doane
authors.forename: Andrew
authors.initials: A
authors.lastname: Gigliotti
authors.forename: D Rick
authors.initials: DR
authors.lastname: Lee
authors.forename: Meg M
authors.initials: MM
authors.lastname: Sleeper
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001241:Aspirin / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D002316:Cardiotonic Agents / Q000627:therapeutic use; D004077:Digoxin / Q000627:therapeutic use; D004232:Diuretics / Q000627:therapeutic use; D004656:Enalapril / Q000627:therapeutic use; D005665:Furosemide / Q000627:therapeutic use; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D009206:Myocardium / Q000473:pathology; D002679:Pan troglodytes; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D018419:Primate Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology
chemical_list: D000959:Antihypertensive Agents; D002316:Cardiotonic Agents; D004232:Diuretics; D010975:Platelet Aggregation Inhibitors; D004656:Enalapril; D004077:Digoxin; D005665:Furosemide; D001241:Aspirin