title: Deficiency and supplementation of PUFA in the diet have similar effects on the age-associated changes in rat-plasma cholesterol levels.
abstract: Levels of plasma cholesterol, particularly LDL cholesterol, increase with increasing age in humans and rodents. Feeding a fish oil-rich diet may exert hypocholesterolemic effects. The aim of this work was to examine the effects of a life-long administration of a PUFA-enriched diet and of a PUFA-deficient diet in male Sprague-Dawley rats on the age-associated increases in plasma cholesterol and triglycerides. Diet had small effects on body-weight, and had dramatic effects on liver phospholipids-fatty acids. Surprisingly, both diets counteracted the age-associated changes in plasma cholesterol and triglycerides similarly and benefits were already visible in adult rats.
authors.affiliation: Centro di Ricerca di Biologia e Patologia dell'Invecchiamento, Università di Pisa, via Roma 55, 56126 Pisa, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Straniero
authors.forename: Gabriella
authors.initials: G
authors.lastname: Cavallini
authors.forename: Alessio
authors.initials: A
authors.lastname: Donati
authors.forename: Maria Rita
authors.initials: MR
authors.lastname: Metelli
authors.forename: Ilaria
authors.initials: I
authors.lastname: Tamburini
authors.forename: Pietro
authors.initials: P
authors.lastname: Pietrini
authors.forename: Ettore
authors.initials: E
authors.lastname: Bergamini
mesh_terms: D000375:Aging / Q000097:blood*; D000818:Animals; D002784:Cholesterol / Q000097:blood*; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D005227:Fatty Acids / Q000737:chemistry / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage*; D008099:Liver / Q000378:metabolism; D008297:Male; D010743:Phospholipids / Q000737:chemistry / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood
chemical_list: D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol