title: Intake of paracetamol and risk of asthma in adults.
abstract: Intake of paracetamol has been associated with development of asthma. The aim of this study was to address a possible association between intake of paracetamol and risk of adult-onset asthma. Using a multidisciplinary postal questionnaire survey concerning health and lifestyle we prospectively studied 19,349 adult twins enrolled in the nationwide Danish Twin Registry. There was a higher prevalence of new-onset asthma in subjects who reported frequent intake of paracetamol at baseline compared with subjects without this determinant (12.0% vs. 4.3%), OR = 3.03 (1.51-6.11), p = 0.005. The result remained significant after adjusting for sex, age, smoking, BMI, hay fever, eczema, and intake of medications other than paracetamol, OR = 2.16 (1.03-4.53), p = 0.041. Frequent intake of paracetamol is an independent risk factor for adult-onset asthma.
authors.affiliation: Department of Respiratory Medicine, Bispebjerg Hospital, Copenhagen, Denmark. sft@city.dk
authors.forename: Simon Francis
authors.initials: SF
authors.lastname: Thomsen
authors.forename: Kirsten Ohm
authors.initials: KO
authors.lastname: Kyvik
authors.forename: Lars
authors.initials: L
authors.lastname: Skadhauge
authors.forename: Ida
authors.initials: I
authors.lastname: Steffensen
authors.forename: Vibeke
authors.initials: V
authors.lastname: Backer
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects* / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000139:chemically induced* / Q000453:epidemiology; D002648:Child; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires
chemical_list: D000082:Acetaminophen