title: [A case of successful control for primary duodenal cancer with combined CPT-11, CDDP and DOC chemotherapy].
abstract: We have experienced a rare case of primary duodenal carcinoma with perforation of the duodenum. Combined CPT- 11, CDDP and DOC chemotherapy achieved a partial response. A 54-year-old man with serious abdominal pain visited our hospital with a diagnosis of acute peritonitis due to perforation of digestive tract on CT scan. An emergency operation was performed with patch for perforation of the duodenum. Endoscopic examination and biopsy after surgery showed duodenal adenocarcinoma. Abdominal CT scan revealed metastasis to the periaortic lymph nodes. Therefore, we diagnosed primary duodenal carcinoma with metastasis to the periaortic lymph nodes. Combined CPT-11, CDDP and DOC chemotherapy were performed. After two courses, endoscopic examination and biopsy showed primary lesion of the duodenum had disappeared. Metastatic lymph nodes were reduced from CT scan after three courses, and successfully controlled until nine courses. Then regimen was changed to S-1 alone and S-1/CPT-11. The patient remained alive for two years after the operation without tumor progression.
authors.affiliation: Department of Surgery, National Hospital Organization Chiba Medical Center.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Satomi
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Morishima
authors.forename: Ichirou
authors.initials: I
authors.lastname: Suzuki
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Aoki
authors.forename: Youichi
authors.initials: Y
authors.lastname: Tazawa
authors.forename: Jun
authors.initials: J
authors.lastname: Kobayashi
authors.forename: Yasuyoshi
authors.initials: Y
authors.lastname: Toyoda
authors.forename: Yukio
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Kaisuke
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Masahiro
authors.initials: M
authors.lastname: Mori
authors.forename: Masayuki
authors.initials: M
authors.lastname: Nakano
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002945:Cisplatin / Q000627:therapeutic use*; D000077143:Docetaxel; D004379:Duodenal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D004384:Duodenoscopy; D006801:Humans; D000077146:Irinotecan; D008297:Male; D008875:Middle Aged; D043823:Taxoids / Q000627:therapeutic use*; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D000077146:Irinotecan; D002945:Cisplatin; D002166:Camptothecin