Signal transduction: turning a switch into a rheostat.
MAP kinase cascades are inherently switch-like, but, during yeast mating, MAPK signaling is graded. A new study suggests that the Ste5 scaffold protein is responsible for making this switch less switch-like.
Bardwell
Lee
L
Department of Developmental and Cell Biology, University of California, Irvine, California 92697, USA. bardwell@uci.edu
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D006801:Humans; D020935:MAP Kinase Signaling System; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*
D048868:Adaptor Proteins, Signal Transducing; C080321:STE5 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins