title: Gastric pepsin in middle ear fluid of children with otitis media: clinical implications.
abstract: Gastroesophageal reflux and extraesophageal reflux have been postulated to be involved in the pathogenesis of otitis media. This is supported by recent studies revealing the presence of gastric pepsin in the middle ear space of children with otitis media but not in control patients without otitis media. Reflux's role in otitis media appears to be most pronounced in younger children and those with purulent effusions.
authors.affiliation: Division of Pediatric Otolaryngology, Alfred I. duPont Hospital for Children, Wilmington, DE 19899, USA.
authors.forename: Zhaoping
authors.initials: Z
authors.lastname: He
authors.forename: Robert C
authors.initials: RC
authors.lastname: O'Reilly
authors.forename: Devendra
authors.initials: D
authors.lastname: Mehta
mesh_terms: D002648:Child; D002675:Child, Preschool; D004432:Ear, Middle / Q000201:enzymology; D005260:Female; D005750:Gastric Juice / Q000201:enzymology*; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000201:enzymology*; D006801:Humans; D008297:Male; D010034:Otitis Media with Effusion / Q000201:enzymology* / Q000209:etiology*; D010434:Pepsin A / Q000378:metabolism*
chemical_list: D010434:Pepsin A