title: Derailed endocytosis: an emerging feature of cancer.
abstract: Once engaged by soluble or matrix-anchored ligands, cell surface proteins are commonly sorted to lysosomal degradation through several endocytic pathways. Defective vesicular trafficking of growth factor receptors, as well as unbalanced recycling of integrin- and cadherin-based adhesion complexes, has emerged in the past 5 years as a multifaceted hallmark of malignant cells. In line with the cooperative nature of endocytic machineries, multiple oncogenic alterations underlie defective endocytosis, such as altered ubiquitylation (Cbl and Nedd4 ubiquitin ligases, for example), altered cytoskeletal interactions and alterations to Rab family members. Pharmaceutical interception of the propensity of tumour cells to derail their signalling and their adhesion receptors may constitute a novel target for cancer therapy.
authors.affiliation: Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel.
authors.forename: Yaron
authors.initials: Y
authors.lastname: Mosesson
authors.forename: Gordon B
authors.initials: GB
authors.lastname: Mills
authors.forename: Yosef
authors.initials: Y
authors.lastname: Yarden
mesh_terms: D015815:Cell Adhesion Molecules / Q000502:physiology; D003599:Cytoskeleton / Q000473:pathology*; D004705:Endocytosis / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism; D054875:Ubiquitination; D014452:Ubiquitins / Q000378:metabolism
chemical_list: D015815:Cell Adhesion Molecules; D014452:Ubiquitins; D044767:Ubiquitin-Protein Ligases