title: Recombinant activated factor VII for treatment of refractory hemorrhage after surgery for acute aortic dissection.
abstract: Despite appropriate treatment, surgery for aortic dissection is frequently associated with bleeding problems. In these series we report on the employment of recombinant activated factor VII (rFVIIa) for refractory hemorrhage after emergency surgery for acute type A aortic dissection, used to face the problems of postoperative blood loss and transfusion requirements. Despite the good results of the therapy, a patient presented with thrombosis of the left cavernous sinus. Although a risk of thromboembolic complications has to be considered, rFVIIa is a reasonable rescue option in life-threatening hemorrhage and enlarges our hemostatic armamentarium in surgery for acute aortic dissection.
authors.affiliation: Department of Cardiovascular Surgery, University of Clinic Charité, Campus Charité Mitte, Berlin, Germany. herko.grubitzsch@charite.de
authors.forename: H
authors.initials: H
authors.lastname: Grubitzsch
authors.forename: O
authors.initials: O
authors.lastname: Vargas-Hein
authors.forename: C
authors.initials: C
authors.lastname: Von Heymann
authors.forename: W
authors.initials: W
authors.lastname: Konertz
mesh_terms: D000208:Acute Disease; D000368:Aged; D000784:Aortic Dissection / Q000601:surgery*; D001014:Aortic Aneurysm / Q000601:surgery*; D001803:Blood Transfusion; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects*; D020226:Cavernous Sinus Thrombosis / Q000139:chemically induced; D015942:Factor VIIa / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006490:Hemostatics / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019106:Postoperative Hemorrhage / Q000188:drug therapy* / Q000209:etiology; D011994:Recombinant Proteins / Q000009:adverse effects / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D006490:Hemostatics; D011994:Recombinant Proteins; C103587:recombinant FVIIa; D015942:Factor VIIa