title: [Research advance of notch signal in ex vivo expansion of hematopoietic progenitor cells - review].
abstract: Ex vivo expansion of hematopoietic progenitor cells (HPCs) is valuable for clinical application, however, traditional ex vivo culture negatively affects long-term hematopoietic reconstitution ability. In the hematopoietic system, the expression of Notch receptors and their ligands has been widely reported. Active Notch signal inhibits the differentiation of HSCs while promotes their expansion, suggesting that ex vivo expansion of hematopoietic progenitor cells could be enhanced by manipulating Notch signal pathways. In this article the Notch signal pathways, Notch signal and maintenance of hematopoietic progenitor cells, Notch signal and expansion of hematopoietic progenitor cells and molecular mechanism of Notch signal maintaining undifferentiation of hematopoietic progenitor cells were reviewed.
authors.affiliation: Department of Hematology, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, Shaanxi Province, China.
authors.forename: Guo-Hui
authors.initials: GH
authors.lastname: Li
authors.forename: Si-Yong
authors.initials: SY
authors.lastname: Huang
authors.forename: Zhi-Jie
authors.initials: ZJ
authors.lastname: Kang
authors.forename: Heng
authors.initials: H
authors.lastname: Xu
authors.forename: Ying-Min
authors.initials: YM
authors.lastname: Liang
mesh_terms: D000818:Animals; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D051880:Receptors, Notch / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D051880:Receptors, Notch