Histological evaluation of Curcuma longa-ghee formulation and hyaluronic acid on gingival healing in dog.
BACKGROUND
The experimental finding of Asian traditional medicine revealed the pharmacological effect of the local application of ghee which was taken from cow butterfat and the rhizomes of Curcuma longa. These materials significantly improved the healing process of the wound. In addition, ancient physicians of Middle East discovered that the powdered rhizomes of Curcuma longa (common turmeric) also had impressive medicinal qualities. Over the centuries, this spice has been used as a pain relieving, anti-inflammatory agent to relieve pain and inflammation in the skin and muscles.


OBJECTIVE
We decided to mix ghee which was taken from sheep butterfat with the powdered rhizomes of Curcuma longa to formulate a novel cost-benefit material and then, evaluate its potential therapeutic effect on acceleration of surgical wound healing; moreover, this present study was performed to compare the effects of Curcuma longa-ghee formulation and hyaluronic acid on gingival wound healing following surgery.


METHODS
Five healthy 3-year-old male beagle dogs were used in this study. They had intact teeth and the clinical and radiographic examination revealed no periodontal disease. Ghee was obtained from the refined sheep butterfat heated to 70 degrees C mixed with the powdered rhizomes of Curcuma longa and was applied with two different ratios including materials A and B. Randomly, these three materials including hyaluronic acid, materials A and B were applied topically in test regions and then covered with periodontal pack. Histological changes were monitored in days 4 and 7 after operation to evaluate the inflammatory and repair stage of healing process.


RESULTS
We observed significant difference in the inflammatory and repair parameters of the healing process between cases treated with this new formulation and cases of hyaluronic acid application.


CONCLUSIONS
The results suggested a positive potential therapeutic effect on surgical wound healing particularly improvement of periodontal treatment consequences after surgery.
Habiboallah
Ghanbari
G
Department of Periodontics, School of Dentistry and Dental Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Nasroallah
Saghravanian
S
Mahdi
Zakery
Z
Nasser
Mahdavi Shahri
MS
Massoud
Zakery
Z
Ehsan
Baradaran Nasseri
BN
Mina
Zareian Jahromi
ZJ
Heidar
Parsaei
P
D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D003362:Cost-Benefit Analysis; D030024:Curcuma / Q000737:chemistry*; D004041:Dietary Fats / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004285:Dogs; D005881:Gingiva / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D005890:Gingivectomy; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007249:Inflammation / Q000188:drug therapy / Q000209:etiology; D008297:Male; D008519:Medicine, Traditional; D008517:Phytotherapy / Q000191:economics / Q000379:methods*; D011897:Random Allocation; D027343:Rhizome / Q000737:chemistry; D012756:Sheep; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000188:drug therapy / Q000473:pathology
D000276:Adjuvants, Immunologic; D004041:Dietary Fats; D006820:Hyaluronic Acid