title: Propagation prevention: a complementary mechanism for "lung protective" ventilation in acute respiratory distress syndrome.
abstract: OBJECTIVE
  To describe the clinical implications of an often neglected mechanism through which localized acute lung injury may be propagated and intensified.
  
  
  METHODS
  Experimental and clinical evidence from the medical literature relevant to the airway propagation hypothesis and its consequences.
  
  
  CONCLUSIONS
  The diffuse injury that characterizes acute respiratory distress syndrome is often considered a process that begins synchronously throughout the lung, mediated by inhaled or blood-borne noxious agents. Relatively little attention has been paid to possibility that inflammatory lung injury may also begin focally and propagate sequentially via the airway network, proceeding mouth-ward from distal to proximal. Were this true, modifications of ventilatory pattern and position aimed at geographic containment of the injury process could help prevent its generalization and limit disease severity. The purposes of this communication are to call attention to this seldom considered mechanism for extending lung injury that might further justify implementation of low tidal volume/high positive end-expiratory pressure ventilatory strategies for lung protection and to suggest additional therapeutic measures implied by this broadened conceptual paradigm.
authors.affiliation: Department of Medicine, University of Minnesota, Minneapolis, Saint Paul, MN, USA. john.j.marini@healthpartners.com
authors.forename: John J
authors.initials: JJ
authors.lastname: Marini
authors.forename: Luciano
authors.initials: L
authors.lastname: Gattinoni
mesh_terms: D055371:Acute Lung Injury / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D008168:Lung / Q000503:physiopathology; D012121:Respiration, Artificial / Q000009:adverse effects* / Q000379:methods; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000503:physiopathology*; D015656:Respiratory Mechanics