Early diagnosis and successful treatment of acute antibody-mediated rejection of a renal transplant.
Antibody-mediated rejection is a delicate situation. It rarely occurs but when it does, it usually results in graft dysfunction and frequently, graft loss. There has been no standard protocol for treating antibody-mediated rejection, although several therapeutic protocols have been recommended. Early detection and treatments of suspected antibody-mediated rejection can secure the graft and improve its function. Here, we describe a typical case of antibody-mediated rejection in a 46-year-old woman who was successfully treated with intravenous immunoglobulin, plasmapheresis, and the anti-CD20 monoclonal antibody, rituximab.
Yang
Ya-Wen
YW
Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Lin
Wei-Chou
WC
Wu
Ming-Shiou
MS
Lee
Po-Huan
PH
Tsai
Meng-Kun
MK
D000017:ABO Blood-Group System / Q000276:immunology; D000373:Agglutinins / Q000276:immunology; D001706:Biopsy; D003404:Creatinine / Q000378:metabolism; D005260:Female; D006084:Graft Rejection / Q000175:diagnosis* / Q000188:drug therapy*; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007518:Isoantibodies / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000601:surgery / Q000628:therapy; D016030:Kidney Transplantation / Q000276:immunology* / Q000473:pathology; D008875:Middle Aged; D006435:Renal Dialysis; D016896:Treatment Outcome
D000017:ABO Blood-Group System; D000373:Agglutinins; D006680:HLA Antigens; D007518:Isoantibodies; D003404:Creatinine