title: Immediate improvement in coronary flow reserve after alcohol septal ablation in patients with hypertrophic obstructive cardiomyopathy.
abstract: OBJECTIVE
  To examine whether percutaneous alcohol septal ablation affects coronary flow reserve (CFR) in patients with hypertrophic cardiomyopathy (HCM).
  
  
  METHODS
  CFR was measured immediately before and after septal ablation in patients with symptomatic obstructive HCM. CFR was also obtained in normal subjects (NL) for comparison.
  
  
  RESULTS
  Patients with HCM (n = 11), compared with NL (n = 22), had a lower mean (SD) baseline CFR (1.96 (0.5) vs 3.0 (0.7), p<0.001), a lower coronary resistance (1.04 (0.45) vs 3.0 (2.6), p = 0.002), a higher coronary diastolic/systolic velocity ratio (DSVR; 5.1 (3.0) vs 1.8 (0.5), p = 0.04) and a lower hyperaemic coronary flow per left ventricular (LV) mass (0.73 (0.4) vs 1.1 (0.6) ml/min/g, p = 0.007). Septal ablation in the HCM group (n = 7) reduced the outflow tract gradient but not the left atrial or LV diastolic pressures. Ablation resulted in immediate normalisation of CFR (to 3.1 (1), p = 0.01) and DSVR (to 1.9 (0.8), p = 0.09) and an increase in coronary resistance (to 1.91 (0.6), p = 0.02). This was probably related to an improvement in the systolic coronary flow.
  
  
  CONCLUSIONS
  This study demonstrates that successful septal ablation in patients with symptomatic HCM results in immediate improvement in CFR, which is reduced in HCM partly because of the increased systolic contraction load.
authors.affiliation: Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
authors.forename: W A
authors.initials: WA
authors.lastname: Jaber
authors.forename: E H
authors.initials: EH
authors.lastname: Yang
authors.forename: R A
authors.initials: RA
authors.lastname: Nishimura
authors.forename: P
authors.initials: P
authors.lastname: Sorajja
authors.forename: C S
authors.initials: CS
authors.lastname: Rihal
authors.forename: A
authors.initials: A
authors.lastname: Elesber
authors.forename: E
authors.initials: E
authors.lastname: Eeckhout
authors.forename: A
authors.initials: A
authors.lastname: Lerman
mesh_terms: D000368:Aged; D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D016022:Case-Control Studies; D017115:Catheter Ablation / Q000379:methods*; D016009:Chi-Square Distribution; D003326:Coronary Circulation / Q000502:physiology*; D015150:Echocardiography, Doppler; D000431:Ethanol / Q000008:administration & dosage*; D005260:Female; D006346:Heart Septum; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D000431:Ethanol