Bioplex analysis of plasma cytokines in Alzheimer's disease and mild cognitive impairment.
Inflammatory mechanisms within the central nervous system contribute to cognitive impairment via cytokine-mediated interactions between neurons and glial cells. Sixty-nine subjects were consecutively recruited from October 2005 to February 2007. Fifteen individuals were excluded from the study and we ultimately enrolled 19 not cognitively impaired subjects, 25 mild cognitive impairment patients, and 10 Alzheimer's disease patients. To examine the inflammatory markers of mild cognitive impairment and Alzheimer's disease, we measured the plasma concentrations of 23 cytokines using a bioplex assay. The results showed that the macrophage migration inhibitory factor was higher in mild cognitive impairment and in Alzheimer's disease patients compared with the not cognitively impaired group; the results also showed that monokine induced by gamma interferon was higher in Alzheimer's disease patients than in not cognitively impaired subjects, as well as those of the mild cognitive impairment group [corrected].
Lee
Kang Soo
KS
Department of Psychiatry, Yonsei University College of Medicine, Seoul, Republic of Korea.
Chung
Ji Hyung
JH
Lee
Kyung Hye
KH
Shin
Min-Jeong
MJ
Oh
Byoung Hoon
BH
Hong
Chang Hyung
CH
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood / Q000175:diagnosis / Q000276:immunology* / Q000523:psychology; D015415:Biomarkers / Q000097:blood; D054370:Chemokine CXCL9 / Q000097:blood* / Q000235:genetics / Q000276:immunology; D003072:Cognition Disorders / Q000097:blood / Q000175:diagnosis / Q000276:immunology* / Q000523:psychology; D016207:Cytokines / Q000097:blood* / Q000235:genetics / Q000276:immunology; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000097:blood* / Q000235:genetics / Q000276:immunology; D008263:Macrophage Migration-Inhibitory Factors / Q000097:blood* / Q000235:genetics / Q000276:immunology; D008297:Male; D011108:Polymers; D011379:Prognosis
D015415:Biomarkers; C080810:CXCL9 protein, human; D054370:Chemokine CXCL9; D016207:Cytokines; D008263:Macrophage Migration-Inhibitory Factors; D011108:Polymers; C004216:bioplex; D019746:Intramolecular Oxidoreductases; C515598:MIF protein, human