Identification of novel acetylenic alcohols and a new dihydrothiopyranone from the tropical sponge Reniochalina sp.
Two new acetylenic alcohols (1-2) and a new dihydrothiopyranone (3) were isolated from the tropical sponge Reniochalina sp. Their structures were determined by spectroscopic and chemical methods to be (3R)-hydroxyoctatriacont-(4E)-en-1-yne (1), 5-hydroxyheptatriacont-(3Z)-en-1-yne (2) and 2-hexadecyl-2,3-dihydrothiopyran-4-one (3). The acetylenic alcohol (1) exhibited significant growth inhibitory effect against human tumor cell lines.
Lee
Hyi-Seung
HS
Korea Ocean Research & Development Institute, Ansan, 426-744, South Korea.
Lee
Ji Hye
JH
Won
Hoshik
H
Park
Song-Kyu
SK
Kim
Hwan Mook
HM
Shin
Hee Jae
HJ
Park
Heung Sik
HS
Sim
Chung J
CJ
Kim
Hye-Kyeong
HK
D000107:Acetylation; D000438:Alcohols / Q000737:chemistry*; D000818:Animals; D006859:Hydrogen / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011161:Porifera / Q000737:chemistry*; D011714:Pyrans / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*
D000438:Alcohols; D011714:Pyrans; D013438:Sulfhydryl Compounds; C522033:thiopyran; D006859:Hydrogen