Living donor liver transplantation for a child with recurrent pediatric adult-type hepatocellular carcinoma.
BACKGROUND
Pediatric hepatocellular carcinoma (HCC) is an uncommon disease with a poor prognosis. There are few reports about liver transplantation for pediatric adult-type HCC. We experienced a case of living donor liver transplantation (LDLT) for a child with recurrent pediatric adult-type HCC.


METHODS
A 12-year-old boy was admitted to the Department of Pediatrics in our institution due to HCC in May 2005. He underwent hepatectomy after 3 courses of chemotherapy in July 2005. After the operation, he had 2 more courses of the same chemotherapy. His posttheraputic course was uneventful for 1 year. However, his alpha-fetoprotein level increased and a computed tomography (CT) scan showed recurrent tumor in his remnant liver in October 2006. He underwent another chemotherapy session immediately. However, CT revealed multiple liver tumors after chemotherapy in December 2006. His mother requested to be an LDLT donor, which was performed on January 23, 2007. The donor operation was a right hepatic lobectomy. The postoperative course of the donor was unremarkable and she has now returned to work. The recipient's posttransplantation course was uneventful and he was discharged at postoperative day 53 and is currently doing well.


CONCLUSIONS
Liver transplantation in conjunction with chemotherapy may have an increasing role in the management of pediatric HCC.
Nara
M
M
Department of Surgery, Hirosaki University School of Medicine, Hirosaki, Aomori, Japan.
Toyoki
Y
Y
Hakamada
K
K
Narumi
S
S
Ishido
K
K
Sugai
M
M
Munakata
H
H
Ito
E
E
Sasaki
M
M
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000601:surgery*; D002648:Child; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000601:surgery*; D019520:Living Donors; D008297:Male; D009364:Neoplasm Recurrence, Local; D016896:Treatment Outcome; D000509:alpha-Fetoproteins / Q000378:metabolism
D000509:alpha-Fetoproteins