title: In vivo comparison of epithelial responses for S-8 versus JP-8 jet fuels below permissible exposure limit.
abstract: This study was designed to characterize and compare the pulmonary effects in distal lung from a low-level exposure to jet propellant-8 fuel (JP-8) and a new synthetic-8 fuel (S-8). It is hypothesized that both fuels have different airway epithelial deposition and responses. Consequently, male C57BL/6 mice were nose-only exposed to S-8 and JP-8 at average concentrations of 53mg/m(3) for 1h/day for 7 days. A pulmonary function test performed 24h after the final exposure indicated that there was a significant increase in expiratory lung resistance in the S-8 mice, whereas JP-8 mice had significant increases in both inspiratory and expiratory lung resistance compared to control values. Neither significant S-8 nor JP-8 respiratory permeability changes were observed compared to controls, suggesting no loss of epithelial barrier integrity. Morphological examination and morphometric analysis of airway tissue demonstrated that both fuels showed different patterns of targeted epithelial cells: bronchioles in S-8 and alveoli/terminal bronchioles in JP-8. Collectively, our data suggest that both fuels may have partially different deposition patterns, which may possibly contribute to specific different adverse effects in lung ventilatory function.
authors.affiliation: Department of Pediatrics, Southwest Environmental Health Sciences Center, The University of Arizona, Tucson, AZ 85274, USA.
authors.forename: Simon S
authors.initials: SS
authors.lastname: Wong
authors.forename: Jason
authors.initials: J
authors.lastname: Vargas
authors.forename: Alana
authors.initials: A
authors.lastname: Thomas
authors.forename: Cindy
authors.initials: C
authors.lastname: Fastje
authors.forename: Michael
authors.initials: M
authors.lastname: McLaughlin
authors.forename: Ryan
authors.initials: R
authors.lastname: Camponovo
authors.forename: R Clark
authors.initials: RC
authors.lastname: Lantz
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Heys
authors.forename: Mark L
authors.initials: ML
authors.lastname: Witten
mesh_terms: D000818:Animals; D004848:Epithelium / Q000187:drug effects*; D006838:Hydrocarbons / Q000494:pharmacology*; D008168:Lung / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012129:Respiratory Function Tests
chemical_list: D006838:Hydrocarbons; C098607:JP8 aviation fuel; C534345:S-8 fuel