Post radical hysterectomy urinary incontinence: a prospective study of transurethral bulking agents injection.
OBJECTIVE
The aim of the present study is to prospectively investigate the efficacy and complications of macroplastique transurethral implantation in cervical cancer patients affected by stress urinary incontinence (SUI) after radical hysterectomy (RH).


METHODS
Patients affected by de novo SUI post type 3 RH were considered for eligibility in this study. Preoperative and postoperative assessment included a standardized urogynecological history, urogynecological and neurological physical examination, evaluation of severity of SUI symptoms, a 3-day voiding diary, urine culture and urodynamic assessment. All patients underwent transurethral implantation using Macroplastique Implantation System (MIS). Patient follow-up was performed 6 and 12 months after surgery.


RESULTS
A total of 24 consecutive patients were enrolled. At the 12 month follow up SUI cure rate was 42% (10 of 24 patients), the improvement rate was 42% (10 of 24) and the failure rate was 16% (4 of 24). The overall success rate was 84% (10 patients cured and 10 improved). No intraoperative or postoperative early complications were found. The 4 patients in whom treatment was not a success had preoperative urethral hypermobility. Subjective patient perception of SUI symptom severity showed significant improvement (mean severity of urinary loss perception 6.6+/-1.8 vs 2.3+/-3.3, p<0.05). The frequency of incontinence on the 3-day voiding diary was significantly reduced at the follow up (14.5+/-5.8 vs 4.3+/-7.9 episodes per 3 days, p<0.05).


CONCLUSIONS
Bulking agents urethral injection could be a valid option having no surgical complications. This therapeutic strategy is able to treat SUI and improve well being of cervical cancer patients after radical surgery.
Plotti
Francesco
F
Department of Gynecology, Obstetrics and Perinatology, University of Rome La Sapienza, Rome, Italy. francescoplotti@tiscali.it
Zullo
Marzio A
MA
Sansone
Milena
M
Calcagno
Marco
M
Bellati
Filippo
F
Angioli
Roberto
R
Panici
Pierluigi Benedetti
PB
D000328:Adult; D001672:Biocompatible Materials / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects*; D008875:Middle Aged; D011446:Prospective Studies; D019736:Prostheses and Implants; D012826:Silicone Elastomers / Q000008:administration & dosage*; D014550:Urinary Incontinence, Stress / Q000209:etiology* / Q000601:surgery*; D002583:Uterine Cervical Neoplasms / Q000601:surgery*
D001672:Biocompatible Materials; D012826:Silicone Elastomers