title: Variations in serum müllerian inhibiting substance between white, black, and Hispanic women.
abstract: OBJECTIVE
  To compare serum müllerian inhibiting substance (MIS) levels between white, black, and Hispanic women to determine whether ovarian aging occurs at a different time course for women of different racial groups.
  
  
  METHODS
  Longitudinal study of serum MIS levels in women of different race and ethnicity over two different time points.
  
  
  METHODS
  Women's Interagency HIV Study, a multicenter prospective cohort study.
  
  
  METHODS
  Serum samples obtained from 809 participants (122 white, 462 black, and 225 Hispanic women).
  
  
  METHODS
  Comparison of serum MIS between women of different race and ethnicity at two time points (median age 37.5 years and 43.3 years).
  
  
  METHODS
  Variation in MIS by race and ethnicity over time, controlling for age, body mass index, HIV status, and smoking.
  
  
  RESULTS
  Compared with white women, average MIS values were lower among black (25.2% lower) and Hispanic (24.6% lower) women, adjusting for age, body mass index, smoking, and HIV status.
  
  
  CONCLUSIONS
  There is an independent effect of race and ethnicity on the age-related decline in MIS over time.
authors.affiliation: Department of Obstetrics and Gynecology, Brooklyn, and Mount Sinai School of Medicine, Maimonides Medical Center, New York, New York 11228, USA. drseifer@genesisfertility.com
authors.forename: David B
authors.initials: DB
authors.lastname: Seifer
authors.forename: Elizabeth T
authors.initials: ET
authors.lastname: Golub
authors.forename: Geralyn
authors.initials: G
authors.lastname: Lambert-Messerlian
authors.forename: Lorie
authors.initials: L
authors.lastname: Benning
authors.forename: Kathryn
authors.initials: K
authors.lastname: Anastos
authors.forename: D Heather
authors.initials: DH
authors.lastname: Watts
authors.forename: Mardge H
authors.initials: MH
authors.lastname: Cohen
authors.forename: Roksana
authors.initials: R
authors.lastname: Karim
authors.forename: Mary A
authors.initials: MA
authors.lastname: Young
authors.forename: Howard
authors.initials: H
authors.lastname: Minkoff
authors.forename: Ruth M
authors.initials: RM
authors.lastname: Greenblatt
mesh_terms: D000328:Adult; D000375:Aging / Q000097:blood / Q000208:ethnology; D054304:Anti-Mullerian Hormone / Q000097:blood*; D044383:Black People / Q000706:statistics & numerical data; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006630:Hispanic or Latino / Q000706:statistics & numerical data; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D010053:Ovary / Q000502:physiology; D044465:White People / Q000706:statistics & numerical data
chemical_list: D054304:Anti-Mullerian Hormone