title: Effect of sucralfate on total carbon dioxide concentration in horses subjected to a simulated race test.
abstract: The purpose of this study was to test the hypothesis that sucralfate, a gastric ulcer medication, would alter plasma concentrations of total carbon dioxide (tCO2), lactate (LA), sodium (Na+), potassium (K+), chloride (Cl-) and total protein (TP), as well as calculated plasma strong ion difference (SID) and packed cell volume (PCV) in horses subjected to a simulated race test (SRT). Six unfit Standardbred mares (approximately 520 kg, 9-18 years) were used in a randomized crossover design with the investigators blinded to the treatment given. The horses were assigned to either a control (40-50 mL apple sauce administered orally (PO)) or a sucralfate (20 mg/kg bodyweight dissolved in 40-50 mL apple sauce administered PO) group. Each horse completed a series of SRTs during which blood samples were taken via jugular venipuncture at five sampling intervals (prior to receiving treatment, prior to SRT, immediately following exercise, and at 60 and 90 min post-SRT). During the SRTs, each horse ran on a treadmill fixed on a 6% grade for 2 min at a warm-up speed (4 m/s) and then for 2 min at a velocity predetermined to produce VO2max. Each horse then walked at 4 m/s for 2 min to complete the SRT. Plasma tCO2, electrolytes, LA, and blood PCV and TP were analysed at all intervals. No differences (P>0.05) were detected between control and sucralfate for any of the measured variables. There were differences (P<0.05) in tCO2, SID, PCV, TP, LA and electrolyte concentrations relative to sampling time. However, these differences were attributable to the physiological pressures associated with acute exercise and were not an effect of the medication. It was concluded that sucralfate did not alter plasma tCO2 concentration in this study.
authors.affiliation: Equine Science Center, Department of Animal Science, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA.
authors.forename: T J
authors.initials: TJ
authors.lastname: Caltabilota
authors.forename: J G
authors.initials: JG
authors.lastname: Milizio
authors.forename: S
authors.initials: S
authors.lastname: Malone
authors.forename: J D
authors.initials: JD
authors.lastname: Kenney
authors.forename: K H
authors.initials: KH
authors.lastname: McKeever
mesh_terms: D000136:Acid-Base Equilibrium / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002245:Carbon Dioxide / Q000097:blood / Q000378:metabolism*; D018592:Cross-Over Studies; D005080:Exercise Test / Q000662:veterinary; D005260:Female; D006734:Horse Diseases / Q000188:drug therapy; D006736:Horses; D010101:Oxygen Consumption / Q000187:drug effects / Q000502:physiology; D010805:Physical Conditioning, Animal / Q000502:physiology; D011897:Random Allocation; D013276:Stomach Ulcer / Q000188:drug therapy / Q000662:veterinary; D013392:Sucralfate / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000897:Anti-Ulcer Agents; D002245:Carbon Dioxide; D013392:Sucralfate