title: Ensuring an exit strategy: RTEL1 restricts rogue recombination.
abstract: Success of homologous recombination-based DNA repair depends not only on recombinases, which promote invasion of the homologous DNA duplex that serves as a template for repair, but also on antirecombinases, which dismantle recombination intermediates to allow completion of repair. In this issue, Barber et al. (2008) identify a previously elusive antirecombinase activity important for maintaining genome stability in animals.
authors.affiliation: Departments of Developmental Biology and Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. villen@cmgm.stanford.edu
authors.forename: Anne M
authors.initials: AM
authors.lastname: Villeneuve
mesh_terms: D000818:Animals; D004249:DNA Damage; D004265:DNA Helicases / Q000378:metabolism*; D004260:DNA Repair; D006801:Humans; D011995:Recombination, Genetic
chemical_list: D004265:DNA Helicases