[Current status of HIV vaccine development].
Despite tremendous efforts to develop HIV vaccines eliciting virus-specific T-cell responses, whether this strategy can really result in HIV control remains unknown. It is important to determine what T-cell responses are responsible for primary HIV control. Recently, encouraging HIV vaccine trials indicated that vaccine induction of highly effective cytotoxic T lymphocytes (CTLs) may result in viral containment in a macaque AIDS model. CTLs exerting strong suppressive effect on viral replication frequently select for escape mutations at the cost of viral fitness. Thus, analysis of CTL-induced viral polymorphisms would contribute to determination of effective CTLs that may be essential for HIV control.
Seki
Sayuri
S
International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo.
Matano
Tetsuro
T
D016915:AIDS Vaccines; D000818:Animals; D015195:Drug Design; D019143:Evolution, Molecular; D006678:HIV / Q000235:genetics / Q000502:physiology; D006801:Humans; D009154:Mutation; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014779:Virus Replication
D016915:AIDS Vaccines