[Effect of dinitrosyl iron complex with glutathione as a nitric oxide donor on blood circulation in healthy animals].
It has been shown that the hypotensive action of the nitric oxide donor, the dinitrosyl complex of iron with glutathione, on the organism of healthy rats, which is caused by a decrease in the general peripherical immunity, does not impair the microcirculation and is accompanied by an enhancement of the contractile activity of the myocardium. In hypotension caused by the dinitrosyl iron complex, neither the tension of oxygen and nitrogen in the blood nor its basic-acidic status changes. Thus, the possible inhibitory action of this complex on some enzymes and proteins in the animal organism does not affect the functioning of the heart, vessels, and blood. The dinitrosyl iron complex with glutathione only causes a decrease in arterial pressure. It is assumed that these complexes as well as dinitrosyl complexes of iron with other thiol ligands may be considered as the basis for designing a novel type of drugs for the treatment of cardiovascular diseases.
Remizova
M I
MI
Kochetygov
N I
NI
Gerbut
K A
KA
Vanin
A F
AF
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D005296:Ferrous Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D005978:Glutathione / Q000031:analogs & derivatives; D007022:Hypotension / Q000139:chemically induced / Q000188:drug therapy; D008833:Microcirculation / Q000187:drug effects*; D009200:Myocardial Contraction / Q000187:drug effects*; D020030:Nitric Oxide Donors / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
D005296:Ferrous Compounds; D020030:Nitric Oxide Donors; C404202:dinitrosylbis(glutathione)iron(II); D005978:Glutathione