title: Design of polymeric carriers for cancer-specific gene targeting: utilization of abnormal protein kinase Calpha activation in cancer cells.
abstract: We succeeded in cancer cell specific gene expression by using a polyplex responsive to protein kinase Calpha, which is activated in various types of cancer cells.
authors.affiliation: Department of Applied Chemistry, Faculty of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan. jrjhkangtcm@mbox.nc.kyushu-u.ac.jp
authors.forename: Jeong-Hun
authors.initials: JH
authors.lastname: Kang
authors.forename: Daisuke
authors.initials: D
authors.lastname: Asai
authors.forename: Jong-Hwan
authors.initials: JH
authors.lastname: Kim
authors.forename: Takeshi
authors.initials: T
authors.lastname: Mori
authors.forename: Riki
authors.initials: R
authors.lastname: Toita
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Tomiyama
authors.forename: Yoji
authors.initials: Y
authors.lastname: Asami
authors.forename: Jun
authors.initials: J
authors.lastname: Oishi
authors.forename: Yuko T
authors.initials: YT
authors.lastname: Sato
authors.forename: Takuro
authors.initials: T
authors.lastname: Niidome
authors.forename: Byungdug
authors.initials: B
authors.lastname: Jun
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakashima
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Katayama
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D045744:Cell Line, Tumor; D054751:Cyclic AMP-Dependent Protein Kinase Catalytic Subunits / Q000378:metabolism*; D004247:DNA / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D004789:Enzyme Activation; D015972:Gene Expression Regulation, Neoplastic; D018390:Gene Targeting / Q000379:methods*; D018014:Gene Transfer Techniques; D006801:Humans; D008156:Luciferases / Q000096:biosynthesis / Q000235:genetics; D008546:Melanoma, Experimental / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D051379:Mice; D010455:Peptides / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D010766:Phosphorylation; D010957:Plasmids / Q000235:genetics; D013379:Substrate Specificity; D014162:Transfection
chemical_list: D010455:Peptides; D004247:DNA; D008156:Luciferases; D054751:Cyclic AMP-Dependent Protein Kinase Catalytic Subunits; C463959:protein kinase A Calpha