title: InterPro: the integrative protein signature database.
abstract: The InterPro database (http://www.ebi.ac.uk/interpro/) integrates together predictive models or 'signatures' representing protein domains, families and functional sites from multiple, diverse source databases: Gene3D, PANTHER, Pfam, PIRSF, PRINTS, ProDom, PROSITE, SMART, SUPERFAMILY and TIGRFAMs. Integration is performed manually and approximately half of the total approximately 58,000 signatures available in the source databases belong to an InterPro entry. Recently, we have started to also display the remaining un-integrated signatures via our web interface. Other developments include the provision of non-signature data, such as structural data, in new XML files on our FTP site, as well as the inclusion of matchless UniProtKB proteins in the existing match XML files. The web interface has been extended and now links out to the ADAN predicted protein-protein interaction database and the SPICE and Dasty viewers. The latest public release (v18.0) covers 79.8% of UniProtKB (v14.1) and consists of 16 549 entries. InterPro data may be accessed either via the web address above, via web services, by downloading files by anonymous FTP or by using the InterProScan search software (http://www.ebi.ac.uk/Tools/InterProScan/).
authors.affiliation: EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. hunter@ebi.ac.uk
authors.forename: Sarah
authors.initials: S
authors.lastname: Hunter
authors.forename: Rolf
authors.initials: R
authors.lastname: Apweiler
authors.forename: Teresa K
authors.initials: TK
authors.lastname: Attwood
authors.forename: Amos
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authors.lastname: Bairoch
authors.forename: Alex
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authors.lastname: Bateman
authors.forename: David
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authors.lastname: Binns
authors.forename: Peer
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authors.lastname: Bork
authors.forename: Ujjwal
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authors.lastname: Das
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authors.lastname: Daugherty
authors.forename: Lauranne
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authors.lastname: Duquenne
authors.forename: Robert D
authors.initials: RD
authors.lastname: Finn
authors.forename: Julian
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authors.lastname: Gough
authors.forename: Daniel
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authors.lastname: Haft
authors.forename: Nicolas
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authors.lastname: Hulo
authors.forename: Daniel
authors.initials: D
authors.lastname: Kahn
authors.forename: Elizabeth
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authors.lastname: Kelly
authors.forename: Aurélie
authors.initials: A
authors.lastname: Laugraud
authors.forename: Ivica
authors.initials: I
authors.lastname: Letunic
authors.forename: David
authors.initials: D
authors.lastname: Lonsdale
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Lopez
authors.forename: Martin
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authors.lastname: Madera
authors.forename: John
authors.initials: J
authors.lastname: Maslen
authors.forename: Craig
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authors.lastname: McAnulla
authors.forename: Jennifer
authors.initials: J
authors.lastname: McDowall
authors.forename: Jaina
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authors.lastname: Mistry
authors.forename: Alex
authors.initials: A
authors.lastname: Mitchell
authors.forename: Nicola
authors.initials: N
authors.lastname: Mulder
authors.forename: Darren
authors.initials: D
authors.lastname: Natale
authors.forename: Christine
authors.initials: C
authors.lastname: Orengo
authors.forename: Antony F
authors.initials: AF
authors.lastname: Quinn
authors.forename: Jeremy D
authors.initials: JD
authors.lastname: Selengut
authors.forename: Christian J A
authors.initials: CJ
authors.lastname: Sigrist
authors.forename: Manjula
authors.initials: M
authors.lastname: Thimma
authors.forename: Paul D
authors.initials: PD
authors.lastname: Thomas
authors.forename: Franck
authors.initials: F
authors.lastname: Valentin
authors.forename: Derek
authors.initials: D
authors.lastname: Wilson
authors.forename: Cathy H
authors.initials: CH
authors.lastname: Wu
authors.forename: Corin
authors.initials: C
authors.lastname: Yeats
mesh_terms: D030562:Databases, Protein; D011506:Proteins / Q000737:chemistry / Q000145:classification; D020539:Sequence Analysis, Protein; D018511:Systems Integration
chemical_list: D011506:Proteins