[Transfusion requirements in chronic kidney disease].
Population-based study suggests that chronic kidney disease is frequent. Almost one third of people older than 70 years of age would have a significant decrease in renal function. Anemia appears when glomerular filtration rate falls under 40mL per minute per 1.73m(2). Concurrently with supplementary iron, erythropoiesis-stimulating agents (ESA) allow a strict control of hemoglobin. However, incomplete responses to ESA are possible. The following conditions - inflammatory disorders, chronic blood loss, hyperparathyroidism, surgical process, chronic diseases, adverse effects of immunosuppressive agents - may cause apparent resistance to ESA therapy. All these conditions may request transfusion.
Frimat
L
L
Service de néphrologie, hôpitaux de Brabois, CHU de Nancy, Vandoeuvre-lès-Nancy, France. l.frimat@chu-nancy.fr
D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D001803:Blood Transfusion; D002908:Chronic Disease; D015897:Comorbidity; D019468:Disease Management; D004351:Drug Resistance; D006301:Health Services Needs and Demand; D006397:Hematinics / Q000627:therapeutic use; D006801:Humans; D007674:Kidney Diseases / Q000150:complications* / Q000453:epidemiology; D017410:Practice Guidelines as Topic; D016032:Randomized Controlled Trials as Topic; D012016:Reference Values
D006397:Hematinics