title: High expression of 90K (Mac-2 BP) is associated with poor survival in node-negative breast cancer patients not receiving adjuvant systemic therapies.
abstract: 90K (Mac-2 BP) expression was evaluated by immunohistochemistry in paraffin-embedded tissue from a consecutive series of lymph-node negative breast cancer patients who did not receive adjuvant systemic treatment. An independent series of patients served as validation set. The association of 90K expression with risk of recurrence and death was examined in survival analyses together with known prognostic factors. High levels of 90K expression (IHC score>8) were observed in 43 (25.3%) of 170 tumors examined. We found elevated risks of distant recurrence and overall mortality in patients with high 90K expression compared with patients with low 90K expression in their tumors. This increase persisted after adjusting for other prognostic factors in multivariate analysis (hazard ratio=4.084; p<0.001 for recurrence; hazard ratio=4.298; p<0.001 for death). These findings were confirmed in the validation set. Therefore, evaluation of 90K expression may be beneficial to identify lymph-node negative breast cancer patients at lower risk of disease recurrence and death.
authors.affiliation: Department of Oncology and Neurosciences, Foundation University G. D'Annunzio, Chieti-Pescara, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Tinari
authors.forename: Rossano
authors.initials: R
authors.lastname: Lattanzio
authors.forename: Patrizia
authors.initials: P
authors.lastname: Querzoli
authors.forename: Clara
authors.initials: C
authors.lastname: Natoli
authors.forename: Antonino
authors.initials: A
authors.lastname: Grassadonia
authors.forename: Saverio
authors.initials: S
authors.lastname: Alberti
authors.forename: Michael
authors.initials: M
authors.lastname: Hubalek
authors.forename: Daniel
authors.initials: D
authors.lastname: Reimer
authors.forename: Italo
authors.initials: I
authors.lastname: Nenci
authors.forename: Paolo
authors.initials: P
authors.lastname: Bruzzi
authors.forename: Mauro
authors.initials: M
authors.lastname: Piantelli
authors.forename: Stefano
authors.initials: S
authors.lastname: Iacobelli
mesh_terms: D000276:Adjuvants, Immunologic; D000368:Aged; D000951:Antigens, Neoplasm / Q000378:metabolism / Q000502:physiology*; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008562:Membrane Glycoproteins / Q000378:metabolism / Q000502:physiology*; D008875:Middle Aged; D008954:Models, Biological; D015999:Multivariate Analysis; D011379:Prognosis; D012306:Risk; D016896:Treatment Outcome
chemical_list: D000276:Adjuvants, Immunologic; D000951:Antigens, Neoplasm; D008562:Membrane Glycoproteins; C114782:TAA90K protein, human