Unstable nucleotide repeat minireview series: a molecular biography of unstable repeat disorders.
Expansion of an unstable nucleotide repeat is a mutational mechanism that is apparently unique to humans and is known to cause a variety of neurological disorders. This collection of minireviews examines several of these unstable repeats, focusing on those where there is considerable molecular information on how the mutation alters function.
Orr
Harry T
HT
Institute of Human Genetics and the Department of Biochemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA. orrxx002@umn.edu
D000818:Animals; D042822:Genomic Instability / Q000235:genetics; D020271:Heredodegenerative Disorders, Nervous System / Q000235:genetics*; D006801:Humans; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*