Reorganization of the nuclear envelope during open mitosis.
The nuclear envelope (NE) provides a selective barrier between the nuclear interior and the cytoplasm and constitutes a central component of intracellular architecture. During mitosis in metazoa, the NE breaks down leading to the complete mixing of the nuclear content with the cytosol. Interestingly, many NE components actively participate in mitotic progression. After chromosome segregation, the NE is reassembled around decondensing chromatin and the nuclear compartment is reestablished in the daughter cells. Here, we summarize recent progress in deciphering the molecular mechanisms underlying NE dynamics during cell division.
Kutay
Ulrike
U
Institute of Biochemistry, ETH Zurich, HPM F11.1, Schafmattstr.18, 8093 Zurich, Switzerland. ulrike.kutay@bc.biol.ethz.ch
Hetzer
Martin W
MW
D000818:Animals; D002455:Cell Division; D002467:Cell Nucleus / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006801:Humans; D008938:Mitosis / Q000502:physiology*; D008954:Models, Biological; D009685:Nuclear Envelope / Q000378:metabolism*; D028861:Nuclear Pore Complex Proteins / Q000378:metabolism
D028861:Nuclear Pore Complex Proteins