HLA class I typing in Egyptian childhood minimal change nephrotic syndrome.
BACKGROUND
Reports on the association between human leukocyte antigens (HLAs) and childhood minimal change nephrotic syndrome (MCNS) are variable. The association between HLA class I and MCNS has not been tested among Egyptian children.


METHODS
We studied such associations in a group of steroid-responsive MCNS Egyptian children (n=37) in comparison to a group of healthy Egyptians (n=100). Typing was performed using standard lymphocytotoxicity assay.


RESULTS
The frequency of HLA-B27 was remarkably higher among MCNS children (18.9%) compared with the control group (1%) (p<0.001, risk ratio [RR] = 3.76, 95% confidence interval [95% CI], 2.5-5.66). Additionally, MCNS children had a significantly higher frequency of HLA-A11 (16.2% vs. 3%) and HLA-B13 (13.5% vs. 2%) (p=0.012 and p=0.016; RR=2.75 and RR=2.9; 95% CI, 1.58-4.79 and 1.66-5.06; respectively). With multivariate analysis, the previous 3 loci were still significant in addition to HLA-B12 (p=0.001, p=0.005, p=0.013 and p=0.033, for HLA-B27, HLA-B13, HLA-A11 and HLA-B12, respectively). The frequency of HLA haplotypes was comparable in both groups.


CONCLUSIONS
We concluded that associations of HLA class I with childhood MCNS in Egypt have both similarities and dissimilarities to those in other populations. HLA-B27, which has not been reported before, has the strongest association. However, similar to studies from other populations, HLA-A11, HLA-B13 and HLA-B12 loci were also associated with MCNS.
Donia
Ahmed Farouk
AF
Department of Nephrology, Urology and Nephrology Center, Mansoura University, Mansoura - Egypt. afdonia@hotmail.com
Ismail
Amani Moustafa
AM
Moustafa
Fatma El-Husseini
Fel-H
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D015234:HLA-A Antigens / Q000032:analysis; D059870:HLA-A11 Antigen; D015235:HLA-B Antigens / Q000032:analysis; D059908:HLA-B13 Antigen; D015796:HLA-B27 Antigen / Q000032:analysis; D006571:Heterocyclic Compounds; D006801:Humans; D008297:Male; D008875:Middle Aged; D009402:Nephrosis, Lipoid / Q000188:drug therapy / Q000276:immunology*; D055815:Young Adult
D006680:HLA Antigens; D015234:HLA-A Antigens; D059870:HLA-A11 Antigen; D015235:HLA-B Antigens; D059908:HLA-B13 Antigen; D015796:HLA-B27 Antigen; D006571:Heterocyclic Compounds; C020876:Crismel