title: Reconstitution of the immune system after hematopoietic stem cell transplantation in humans.
abstract: Hematopoietic stem cell transplantation is associated with a severe immune deficiency. As a result, the patient is at high risk of infections. Innate immunity, including epithelial barriers, monocytes, granulocytes, and NK cells recovers within weeks after transplantation. By contrast, adaptive immunity recovers much slower. B- and T-cell counts normalize during the first months after transplantation, but in particular, T-cell immunity may remain impaired for years. During the last decade, much of the underlying mechanisms have been identified. These insights may provide new therapies to accelerate recovery.
authors.affiliation: Division of Hematology and Hematologic Malignancies, Department of Medicine, University of Calgary, Calgary, AB, Canada.
authors.forename: Jan
authors.initials: J
authors.lastname: Storek
authors.forename: Michelle
authors.initials: M
authors.lastname: Geddes
authors.forename: Faisal
authors.initials: F
authors.lastname: Khan
authors.forename: Bertrand
authors.initials: B
authors.lastname: Huard
authors.forename: Claudine
authors.initials: C
authors.lastname: Helg
authors.forename: Yves
authors.initials: Y
authors.lastname: Chalandon
authors.forename: Jakob
authors.initials: J
authors.lastname: Passweg
authors.forename: Eddy
authors.initials: E
authors.lastname: Roosnek
mesh_terms: D000938:Antigen-Presenting Cells / Q000166:cytology / Q000276:immunology; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007107:Immune System / Q000166:cytology* / Q000276:immunology*; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology