title: Synthesis and characterization of novel natural product-Gd(III) MRI contrast agent conjugates.
abstract: Several novel gadolinium chelates conjugated with paclitaxel, colchicine and thyroxine have been prepared as MRI contrast agents targeted to tubulin and thyroxine-binding globulin, respectively.
authors.affiliation: Chemical Biology Program, Institute of Physical Chemistry, NCSR 'DEMOKRITOS', PO Box 60228, GR-153 10 Aghia, Paraskevi, Greece.
authors.forename: Eleni K
authors.initials: EK
authors.lastname: Efthimiadou
authors.forename: Maria E
authors.initials: ME
authors.lastname: Katsarou
authors.forename: Michael
authors.initials: M
authors.lastname: Fardis
authors.forename: Christos
authors.initials: C
authors.lastname: Zikos
authors.forename: Emmanuel N
authors.initials: EN
authors.lastname: Pitsinos
authors.forename: Athanasios
authors.initials: A
authors.lastname: Kazantzis
authors.forename: Leondios
authors.initials: L
authors.lastname: Leondiadis
authors.forename: Marina
authors.initials: M
authors.lastname: Sagnou
authors.forename: Dionisios
authors.initials: D
authors.lastname: Vourloumis
mesh_terms: D003078:Colchicine / Q000737:chemistry; D003287:Contrast Media / Q000138:chemical synthesis* / Q000737:chemistry; D005260:Female; D005682:Gadolinium / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008279:Magnetic Resonance Imaging; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D017239:Paclitaxel / Q000737:chemistry; D013974:Thyroxine / Q000737:chemistry; D013975:Thyroxine-Binding Proteins / Q000187:drug effects*; D014404:Tubulin / Q000187:drug effects*
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D013975:Thyroxine-Binding Proteins; D014404:Tubulin; D005682:Gadolinium; D017239:Paclitaxel; D013974:Thyroxine; D003078:Colchicine