Configurational assignment of rhizopodin, an actin-binding macrolide from the myxobacterium Myxococcus stipitatus.
The relative and absolute stereochemistry of the 38-membered myxobacterial polyketide rhizopodin, a potent actin-binding macrolide, was determined by J-based configurational analysis in combination with molecular modeling and chemical derivatization.
Horstmann
Nicole
N
Helmholtz-Zentrum für Infektionsforschung GmbH, Medizinische Chemie, Inhoffenstr. 7, 38124 Braunschweig, Germany, EU.
Menche
Dirk
D
D000199:Actins / Q000737:chemistry*; D018942:Macrolides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D016940:Myxococcus / Q000737:chemistry*; D010080:Oxazoles / Q000737:chemistry*; D011487:Protein Conformation; D013237:Stereoisomerism
D000199:Actins; D018942:Macrolides; D010080:Oxazoles; C081739:rhizopodin