title: Clinical correlate of brain SPECT perfusion abnormalities in fibromyalgia.
abstract: The purpose of this study was to investigate the specific clinical correlate of brain SPECT perfusion abnormalities reported in fibromyalgia.
  
  
  METHODS
  We performed a whole-brain voxel-based correlation analysis involving regional cerebral blood flow and various parameters related to pain (Visual Analog Scale, Tubingen Pain Behavior Scale, and Questionnaire Douleur de Saint-Antoine Scale), disability (Fibromyalgia Impact Questionnaire [FIQ]), and anxiety and depression status (Hospital Anxiety and Depression scale) in 20 patients with fibromyalgia (P voxel < 0.005). Ten healthy control women were also included, in order to determine areas of significant hypo- and hyperperfusions in patients.
  
  
  RESULTS
  FIQ total score was positively correlated with bilateral parietal perfusion, including postcentral cortex. These clusters of correlation were included in the areas of significant hyperperfusion. FIQ total score was also negatively correlated with perfusion of a left anterior temporal cluster, included in the areas of significant hypoperfusions. No other clinical correlation was observed with regional cerebral blood flow.
  
  
  CONCLUSIONS
  These results show that brain perfusion abnormalities in patients with fibromyalgia are correlated with the clinical severity of the disease.
authors.affiliation: Service Central de Biophysique et de Médecine Nucléaire, AP-HM Timone, Marseille, France. eric.guedj@ap-hm.fr
authors.forename: Eric
authors.initials: E
authors.lastname: Guedj
authors.forename: Serge
authors.initials: S
authors.lastname: Cammilleri
authors.forename: Jean
authors.initials: J
authors.lastname: Niboyet
authors.forename: Patricia
authors.initials: P
authors.lastname: Dupont
authors.forename: Eric
authors.initials: E
authors.lastname: Vidal
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Dropinski
authors.forename: Olivier
authors.initials: O
authors.lastname: Mundler
mesh_terms: D000328:Adult; D001007:Anxiety / Q000150:complications; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging*; D016022:Case-Control Studies; D003863:Depression / Q000150:complications; D005260:Female; D005356:Fibromyalgia / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D006801:Humans; D008875:Middle Aged; D010146:Pain; D011247:Pregnancy; D013223:Statistics as Topic; D015899:Tomography, Emission-Computed, Single-Photon