[Changes of platelet aggregation function of apheresis collected platelets and soluble P-selectin during storage].
The objective of this study was to explore the changes of aggregation function of apheresis platelets and soluble P-selectin (sP-selectin) during storage. 20 samples of apheresis platelets were collected, and the aggregation function were examined by function test and the level of sP-selectin every day in storage of 5 days. The results showed that the aggregation function of platelets declined obviously during storage, there were significant differences between the first-day group and any of the other groups (p < 0.01). The max platelet aggregation rate was < or = 3% in the fourth-day group; sP-selectin level in plasma increased with prolong of storage time; there were significant differences between the first-day group and any of the other groups (p < 0.05). In conclusion, platelets were activated continuously during storage, while its aggregation function declines significantly. The ability of platelet aggregation to response to ADP loses almost completely since the fourth day during platelet storage. It should be paid more attention to the damage of apheresis collected platelets during storage.
Xie
Zuo-Ting
ZT
Department of Blood Transfusion, The First Hospital, Wenzhou Medical College, Wenzhou 325000, Zhejiang Province, China. xzt@163.com
Yang
Li-Hong
LH
Tao
Zhi-Hua
ZH
Wang
Ming-Shan
MS
Hong
Jun-Ying
JY
Zhou
Wu
W
Chen
Zeng-Qiang
ZQ
Dai
Mei-Jie
MJ
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism* / Q000502:physiology*; D006801:Humans; D008297:Male; D019007:P-Selectin / Q000097:blood*; D010974:Platelet Aggregation; D010976:Platelet Count; D010983:Plateletpheresis / Q000379:methods; D013048:Specimen Handling
D019007:P-Selectin