The major histocompatibility complex class Ib molecule HLA-E at the interface between innate and adaptive immunity.
The non-classical major histocompatibility complex (MHC) class I molecule human leucocyte antigen (HLA)-E is the least polymorphic of all the MHC class I molecules and acts as a ligand for receptors of both the innate and the adaptive immune systems. The recognition of self-peptides complexed to HLA-E by the CD94-NKG2A receptor expressed by natural killer (NK) cells represents a crucial checkpoint for immune surveillance by NK cells. However, HLA-E can also be recognised by the T-cell receptor expressed by alphabeta CD8 T cells and therefore can play a role in the adaptive immune response to invading pathogens. The recent resolution of HLA-E in complex with both innate and adaptive ligands has provided insight into the dual role of this molecule in immunity.
Sullivan
L C
LC
Department of Microbiology and Immunology, University of Melbourne, Parkville, VIC 3010, Australia.
Clements
C S
CS
Rossjohn
J
J
Brooks
A G
AG
D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D006680:HLA Antigens / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*; D018380:Hematopoietic Stem Cell Transplantation; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007110:Immunity, Active / Q000276:immunology; D007113:Immunity, Innate / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism; D051920:NK Cell Lectin-Like Receptor Subfamily D / Q000276:immunology / Q000378:metabolism*; D011110:Polymorphism, Genetic; D054730:Protein Interaction Domains and Motifs / Q000502:physiology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology / Q000378:metabolism*; D055607:Receptors, Natural Killer Cell / Q000276:immunology / Q000378:metabolism; D000097625:HLA-E Antigens
D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I; D051920:NK Cell Lectin-Like Receptor Subfamily D; D011948:Receptors, Antigen, T-Cell; D055607:Receptors, Natural Killer Cell; D000097625:HLA-E Antigens