Photocontact dermatitis to ketoprofen presenting with erythema multiforme.
A 74-year-old Japanese man developed erythema multiforme on the inner aspect of his left elbow where ketoprofen-containing tape was applied and exposed to sunlight, and the eruption subsequently spread to the four limbs and trunk. The lesions were successfully treated with systemic corticosteroids without recurrence. Lymphocyte stimulation tests with ketoprofen-photomodified peripheral blood mononuclear cells revealed that the patient had circulating lymphocytes reactive with a photohaptenic moiety of ketoprofen. To our knowledge, this is the first case of erythema multiforme induced by photocontact dermatitis. The presence of circulating photoantigen-reactive T cells seemed to induce erythema multiforme as an unusual manifestation in this patient.
Izu
Kunio
K
Department of Dermatology, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Iseigaoka, Kitakyushu 807-8555, Japan.
Hino
Ryosuke
R
Isoda
Hideka
H
Nakashima
Daiki
D
Kabashima
Kenji
K
Tokura
Yoshiki
Y
D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D017454:Dermatitis, Photoallergic / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D004892:Erythema Multiforme / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D007660:Ketoprofen / Q000009:adverse effects*; D008213:Lymphocyte Activation; D008297:Male
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007660:Ketoprofen