Endogenous glucocorticoids participate in retinal degeneration during continuous illumination.
Continuous illumination (CI) induces an oxidative stress of the retina which is involved in light-induced retinal degeneration (LIRD). As the increase of glucocorticoids (GC) could also collaborate in the damage, adrenalectomized (ADX) and sham-operated rats (control, CTL) were submitted to CI, and their eyes were studied at light and electron microscopic levels. After CI, ADX retinas were significantly thicker than CTL retinas. Retinal alterations appeared earlier and were severer in CTL than in ADX retinas. Corticosterone levels increased gradually in the sera of CTL rats along CI. These results suggest that adrenalectomy attenuates LIRD, supporting the hypothesis.
López
Ester María
EM
Facultad de Medicina, Instituto de Biología Celular y Neurociencia Prof E De Robertis, Universidad de Buenos Aires, Buenos Aires, Argentina.
Julián
Lilian Karina
LK
Capani
Francisco
F
Cymeryng
Cora Beatriz
CB
Coirini
Hector
H
López-Costa
Juan José
JJ
D000315:Adrenalectomy; D000818:Animals; D003345:Corticosterone / Q000097:blood; D005938:Glucocorticoids / Q000097:blood*; D008027:Light / Q000009:adverse effects*; D008029:Lighting / Q000009:adverse effects; D008297:Male; D046529:Microscopy, Electron, Transmission; D009474:Neurons / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects; D018384:Oxidative Stress / Q000502:physiology / Q000528:radiation effects; D020419:Photoreceptor Cells, Vertebrate / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012160:Retina / Q000378:metabolism* / Q000473:pathology / Q000528:radiation effects*; D012162:Retinal Degeneration / Q000209:etiology* / Q000378:metabolism* / Q000503:physiopathology; D015854:Up-Regulation / Q000502:physiology / Q000528:radiation effects
D005938:Glucocorticoids; D003345:Corticosterone