The differences of platelet response to snake venoms: a comparative study of children and adults.
Platelets play a vital role in the coagulation, yet the potential for differences in platelet function, between adults and children, remains underexplored. This is despite the age-related variation in haemostatic proteins, that is encompassed by the term Developmental Haemostasis. Hemotoxins found in the venoms of Australian snakes mimic human blood coagulation factors. The effects of Australian snake venoms on platelets, as well as the possible differential response in adults and children were subject of this study.
Kern
L P
LP
IMC Krems, University of Applied Sciences, Austria; Department of Pathology, The University of Melbourne, Australia; Australian Venom Research Unit, The University of Melbourne, Australia. larissa_k@gmx.at
Ignjatovic
V
V
Winkel
K D
KD
Summerhayes
R
R
Monagle
P
P
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000818:Animals; D002648:Child; D002675:Child, Preschool; D004546:Elapid Venoms / Q000494:pharmacology*; D017815:Elapidae; D006801:Humans; D007223:Infant; D010974:Platelet Aggregation / Q000187:drug effects*
D004546:Elapid Venoms