Ocular surface squamous neoplasia as the first apparent  manifestation of HIV infection in Malawi.
OBJECTIVE
To evaluate the prevalence of undiagnosed and asymptomatic HIV infection in patients with ocular surface squamous neoplasia (OSSN) in an urban patient population in Malawi.


METHODS
A consecutive series of patients presenting with OSSN was evaluated in an African academic centre. A detailed history and physical examination in 53 consecutive patients with conjunctival squamous cell carcinoma and conjunctival intraepithelial neoplasia were performed. Thirty eight (72%) patients agreed to undergo serological HIV testing.


RESULTS
Seventy-nine per cent (30 of 38) patients were HIV positive. None of the patients had previous HIV testing or was aware of having symptoms of HIV. Seventy per cent (n = 21) of the HIV-positive patients had no other symptoms suggestive of HIV infection or any other disease. Patients were far more likely to refuse HIV testing if they were married and male.


CONCLUSIONS
The conjunctival tumour may be the primary and only apparent manifestation of HIV in patients presenting with OSSN in Sub-Saharan Africa.
Spitzer
Martin S
MS
Lion's Sight First Eye Hospital, College of Medicine, Blantyre, Malawi. martin.spitzer@med.uni-tuebingen.de
Batumba
Nkume H
NH
Chirambo
Tamara
T
Bartz-Schmidt
Karl U
KU
Kayange
Petros
P
Kalua
Khumbo
K
Szurman
Peter
P
D000328:Adult; D002278:Carcinoma in Situ / Q000473:pathology / Q000821:virology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000821:virology*; D003230:Conjunctival Neoplasms / Q000473:pathology / Q000821:virology*; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000503:physiopathology; D006562:Herpes Zoster / Q000150:complications; D006801:Humans; D008295:Malawi; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D014376:Tuberculosis / Q000150:complications; D015431:Weight Loss