Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance.
Wehmeier
Caroline
C
Schuster
Sabine
S
Fähnrich
Eva
E
Kern
Winfried V
WV
Bohnert
Jürgen A
JA
D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics* / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D018942:Macrolides / Q000494:pharmacology*; D008969:Molecular Sequence Data; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D016297:Mutagenesis, Site-Directed / Q000379:methods*; D017386:Sequence Homology, Amino Acid
D000900:Anti-Bacterial Agents; D029968:Escherichia coli Proteins; D018942:Macrolides; D027425:ATP-Binding Cassette, Sub-Family C Proteins; C083496:AcrB protein, E coli