title: CYP17 and CYP19 gene polymorphisms in women affected with endometriosis.
abstract: OBJECTIVE
  To investigate whether CYP17 T>C polymorphism and polymorphisms C1558T and Val80 of CYP19 are related to endometriosis.
  
  
  METHODS
  Clinical study.
  
  
  METHODS
  Women affected with endometriosis (n = 104) and control group (n = 86). The diagnosis of endometriosis was confirmed by the histologic examination of the endometriotic lesions.
  
  
  RESULTS
  In patients affected with endometriosis, we observed that AA and CC genotypes were significantly represented in Val80 and C1558T polymorphisms of CYP19.
  
  
  CONCLUSIONS
  The molecular mechanisms that underlie the development of endometriosis are unclear. Both environmental and genetic factors are involved in the pathogenesis of the disease. The inheritable susceptibility to endometriosis justifies the growing interest in identifying genes and/or genetic polymorphisms that predispose women to an increased risk of developing endometriosis. The identification of single-nucleotide polymorphism (SNP), probably linked to endometriosis, could help to explain its pathogenesis.
authors.affiliation: Department of General Pathology, Second Medical School of Naples, Naples, Italy.
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Vietri
authors.forename: Michele
authors.initials: M
authors.lastname: Cioffi
authors.forename: Marcella
authors.initials: M
authors.lastname: Sessa
authors.forename: Serena
authors.initials: S
authors.lastname: Simeone
authors.forename: Paola
authors.initials: P
authors.lastname: Bontempo
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Trabucco
authors.forename: Mario
authors.initials: M
authors.lastname: Ardovino
authors.forename: Nicola
authors.initials: N
authors.lastname: Colacurci
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Molinari
authors.forename: Luigi
authors.initials: L
authors.lastname: Cobellis
mesh_terms: D000293:Adolescent; D000328:Adult; D001141:Aromatase / Q000235:genetics*; D016022:Case-Control Studies; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D010049:Ovarian Diseases / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000502:physiology; D013254:Steroid 17-alpha-Hydroxylase / Q000235:genetics*; D055815:Young Adult
chemical_list: D001141:Aromatase; D013254:Steroid 17-alpha-Hydroxylase