Diastereoselective palladium-catalyzed alpha-arylation of 4-substituted cyclohexyl esters.
A diastereoselective palladium-catalyzed arylation of 4-substituted cyclohexyl esters has been developed. The reaction proceeds at room temperature in the presence of [(t-Bu3P)PdBr]2 providing products in up to 37:1 dr.
Bercot
Eric A
EA
Chemical Process R&D, Amgen Inc, Thousand Oaks, California 91320, USA. ebercot@amgen.com
Caille
Seb
S
Bostick
Tracy M
TM
Ranganathan
Krishnakumar
K
Jensen
Randy
R
Faul
Margaret M
MM