title: Quantification of cerebrospinal fluid ferritin as a biomarker for CNS malignant infiltration.
abstract: Several markers have been studied for their ability to make the CNS infiltration diagnosis earlier and more precise; previous studies showed that CSF ferritin concentrations were higher in patients with malignant invasion of CNS. The objective was to determine the importance of CSF ferritin as a biomarker for the diagnosis of CNS neoplastic infiltration. This study is based on 93 CSF samples, divided into five groups: malignant cells present (n13); malignant cells not present (n26); inflammatory neurological diseases (n16); neurocysticercosis (n20); acute bacterial meningitis (n18). CSF ferritin values were determined by micro particle enzyme immunoassay. CSF ferritin level (mean+/-SD) in the group with neoplastic cells in the CSF was 42.8+/-49.7 ng/mL, higher than in the other groups (p<0.0001). We conclude that CSF ferritin with the cut off 20 ng/mL could be an adjuvant biomarker to the diagnosis of CNS malignant infiltration.
authors.affiliation: Clinical Pathology Laboratory, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil. sergio.ma@pop.com.br
authors.forename: Sérgio Monteiro de
authors.initials: SM
authors.lastname: Almeida
authors.forename: Dione Sosnitzki da
authors.initials: DS
authors.lastname: Cunha
authors.forename: Edna
authors.initials: E
authors.lastname: Yamada
authors.forename: Elvira Missako
authors.initials: EM
authors.lastname: Doi
authors.forename: Margaret
authors.initials: M
authors.lastname: Ono
mesh_terms: D014408:Biomarkers, Tumor / Q000134:cerebrospinal fluid*; D016543:Central Nervous System Neoplasms / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D004797:Enzyme-Linked Immunosorbent Assay; D005293:Ferritins / Q000134:cerebrospinal fluid*; D006801:Humans; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; D005293:Ferritins