Correlation between body weight (epididymal fat) and permeation rate of serum leptin through the blood-brain barrier (BBB) in male rats aged 8 months.
In this study, in order to clarify the kinetics of leptin, we focused on the ratio of leptin concentrations in cerebrospinal fluid and serum in aged male rats, and examined the weight of epididymal fat, and the passage rate of leptin through the blood-brain barrier. In the lighter animals, the epididymal fat weight was low, while leptin concentrations in the serum and cerebrospinal fluid were also low. Conversely, in the heavier animals, the weight of epididymal fat and leptin concentrations in the serum and cerebrospinal fluid were higher. With regard to the ratio of leptin in the cerebrospinal fluid and serum, the passage rate of leptin through the blood-brain barrier was lower in the heavier animals than in the lighter animals.
Suzuki
Mitsuro
M
Behavioral Neuroscience Section, Nippon Veterinary and Life Science University, Tokyo, Japan.
Ding
Qing
Q
Muranaka
Shiro
S
Kigure
Megumi
M
Kojima
Masaaki
M
Terada
Misao
M
Kataoka
Noyuri
N
Hagiwara
Akiko
A
Kromkhun
Pudcharaporn
P
Moritani
Naoki
N
Hashimoto
Haruo
H
Yokosuka
Makoto
M
Sakurai
Fujiro
F
Tanaka
Minoru
M
Saito
Toru R
TR
D000273:Adipose Tissue / Q000033:anatomy & histology*; D000375:Aging; D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology*; D001835:Body Weight; D004822:Epididymis / Q000033:anatomy & histology*; D020738:Leptin / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D008297:Male; D051381:Rats
D020738:Leptin