Apical junctions and growth control in Drosophila.
Recent studies have revealed unexpected links between cell polarity and proliferation, suggesting that the polarized organization of cells is necessary to regulate growth. Drosophila melanogaster is a genetically simple model that is especially suited for the study of polarity and growth control, as polarized tissues undergo a well-defined pattern of proliferation and differentiation during the development. In addition, genetic studies have identified a number of tumor suppressor genes, which later studies have shown to be associated with junctions, or in the regulation of junctional proteins. We will explore in this review the links between growth and apical junction proteins in the regulation of growth control in Drosophila.
Badouel
Caroline
C
Samuel Lunenfeld Research Institute, Mt. Sinai Hospital, Toronto, Canada.
McNeill
Helen
H
D022005:Adherens Junctions / Q000502:physiology*; D000818:Animals; D015815:Cell Adhesion Molecules / Q000502:physiology; D029721:Drosophila Proteins / Q000502:physiology; D004331:Drosophila melanogaster / Q000254:growth & development*; D066246:ErbB Receptors / Q000502:physiology; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology; D008565:Membrane Proteins / Q000502:physiology; D025581:Neurofibromin 2 / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D000099317:Hippo Kinases
D015815:Cell Adhesion Molecules; D029721:Drosophila Proteins; D066246:ErbB Receptors; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D025581:Neurofibromin 2; D017346:Protein Serine-Threonine Kinases; C085090:ex protein, Drosophila; C472307:ft protein, Drosophila; C099885:merlin, Drosophila; C499474:hpo protein, Drosophila; D000099317:Hippo Kinases