title: Association between high miR-211 microRNA expression and the poor prognosis of oral carcinoma.
abstract: MicroRNAs (miRNAs) are non-coding RNAs that play roles in gene silencing and may be involved in tumorigenesis. miR-211 was mapped to chromosome 15q13, a locus frequently altered in cancers. The role of miR-211 in carcinogenesis has not been clearly defined, however. This study investigated the pathogenetic implications of miR-211 in oral carcinogenesis. An association was found between higher miR-211 expression and the most advanced nodal metastasis, vascular invasion, and poor prognosis of oral carcinoma. The function of enforced miR-211 expression in oral carcinoma cells was confirmed by the repression of LacZ in a reporter plasmid via miR-211 targeting. Enforced miR-211 expression significantly increased the proliferation, migration, and anchorage-independent colony formation of oral carcinoma cells, while it enhanced the tumorigenicity of only SAS high-grade oral carcinoma cells, but not OECM-1 non-tumorigenic cells. The findings suggest that high miR-211 expression may be associated with the progression of oral carcinoma and poor patient outcomes.
authors.affiliation: Institute of Oral Biology, School of Dentistry, National Yang-Ming University, No. 155, Li-Nong St., Sec.2, Taipei, Taiwan.
authors.forename: K-W
authors.initials: KW
authors.lastname: Chang
authors.forename: C-J
authors.initials: CJ
authors.lastname: Liu
authors.forename: T-H
authors.initials: TH
authors.lastname: Chu
authors.forename: H-W
authors.initials: HW
authors.lastname: Cheng
authors.forename: P-S
authors.initials: PS
authors.lastname: Hung
authors.forename: W-Y
authors.initials: WY
authors.lastname: Hu
authors.forename: S-C
authors.initials: SC
authors.lastname: Lin
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000378:metabolism; D016022:Case-Control Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D035683:MicroRNAs / Q000096:biosynthesis*; D009062:Mouth Neoplasms / Q000235:genetics* / Q000378:metabolism; D009389:Neovascularization, Pathologic; D010641:Phenotype; D011230:Precancerous Conditions / Q000235:genetics* / Q000378:metabolism; D011379:Prognosis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014162:Transfection
chemical_list: D035683:MicroRNAs; C525709:MIR221, human