Hepcidin, an antimicrobial peptide is downregulated in ceruloplasmin-deficient mice.
Hepcidin, a principle regulator of iron metabolism, is synthesized by the liver. Contradictory results have been reported on the regulation of hepcidin expression in response to serum transferrin saturation and liver iron content. In the present study, we explore the expression of murine hepcidin mRNA and further analyze the relationship between liver hepcidin mRNA expression, liver iron stores, and serum iron level utilizing ceruloplasmin gene knockout mice. We find that hepcidin expression correlates significantly with serum transferrin saturation, whereas there is a negative correlation of hepcidin expression with liver tissue iron level.
Guo
Pei
P
Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang 050016, Hebei Province, People's Republic of China.
Cui
Rui
R
Chang
Yan-Zhong
YZ
Wu
Wen-Shuang
WS
Qian
Zhong-Ming
ZM
Yoshida
Kunihiro
K
Qiao
Ya-Tiao
YT
Takeda
Shin'ichi
S
Duan
Xiang-Lin
XL
D000818:Animals; D000890:Anti-Infective Agents / Q000378:metabolism*; D023181:Antimicrobial Cationic Peptides / Q000235:genetics* / Q000378:metabolism; D002570:Ceruloplasmin / Q000235:genetics* / Q000378:metabolism; D015536:Down-Regulation / Q000235:genetics*; D005838:Genotype; D064451:Hepcidins; D007501:Iron / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D010641:Phenotype; D012333:RNA, Messenger / Q000378:metabolism; D014168:Transferrin / Q000378:metabolism
D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides; C579599:Hamp protein, mouse; D064451:Hepcidins; D012333:RNA, Messenger; D014168:Transferrin; D007501:Iron; D002570:Ceruloplasmin