Synthetic studies of heterocyclic natural products.
Recent reports of the syntheses of heterocyclic natural products that are isolated from bacteria, fungi, plants and marine sources are discussed. This review emphasizes new developments in synthetic methodology and strategies for such products, and the potential biological activity of the metabolites that are described is highlighted. Concepts of conformational analysis, stereoelectronic control and reaction mechanism are all used in the development of new methodology. Despite the variety and scope of synthetic efforts, the synthesis of new organic molecules and the improved synthesis of known molecules remains a major task for organic chemists.
Joullié
Madeleine M
MM
University of Pennsylvania, Department of Chemistry, 231 South 34th Street, Philadelphia, PA 19104, USA. mjoullie@sas.upenn.edu
Berritt
Simon
S
Forbeck
Erin M
EM
D001688:Biological Products / Q000138:chemical synthesis*; D055808:Drug Discovery; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D013237:Stereoisomerism
D001688:Biological Products; D006571:Heterocyclic Compounds