title: [A case of gastric gastrointestinal stromal tumor operated after low-dose chemotherapy with imatinib mesylate].
abstract: A 76-year-old man was admitted to our hospital because of tarry motions. Endoscopic findings showed an ulcer on a large submucosal tumor in the stomach. Abodminal CT scan showed a protruding lesion of approximately 13 cm at the lumen of the gastric body. FDG-PET imaging revealed FDG uptake in the gastric body and abdominal cavity. We diagnosed it as GIST with peritoneal dissemination clinically, and treatment with 300 mg of imatinib mesylate was started in December 2006. The main tumor was reduced(reduction rate of 27%)and FDG-PET imaging revealed a decrease in FDG uptake in the main tumor and all disseminated tumors after 5 months of treatment. However, the drug was discontinued for arthritis(grade 3). Partial gastrectomy with sampling peritoneal nodules was performed in June 2007. The present case suggests that low-dose chemotherapy with imatinib mesylate may be useful as a preoperative therapy for a minimal surgery.
authors.affiliation: Department of Surgery, Izumi General Medical Center.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Hori
authors.forename: Norihisa
authors.initials: N
authors.lastname: Hanada
authors.forename: Shuichi
authors.initials: S
authors.lastname: Kusano
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Tsurumoto
authors.forename: Naomi
authors.initials: N
authors.lastname: Sakashita
authors.forename: Ryojin
authors.initials: R
authors.lastname: Uchino
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001549:Benzamides; D001706:Biopsy; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005773:Gastroscopy; D006801:Humans; D000068877:Imatinib Mesylate; D008297:Male; D010879:Piperazines / Q000627:therapeutic use*; D049268:Positron-Emission Tomography; D011743:Pyrimidines / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate