Docosahexaenoic acid and cognitive function: Is the link mediated by the autonomic nervous system?
Docosahexaenoic acid is a long-chain polyunsaturated fatty acid that is found in large quantity in the brain and which has repeatedly been observed to be related in positive ways to both cognitive function and cardiovascular health. The mechanisms through which docosahexaenoic acid affects cognition are not well understood, but in this article, we propose a hypothesis that integrates the positive effects of docosahexaenoic acid in the cognitive and cardiovascular realms through the autonomic nervous system. The autonomic nervous system is known to regulate vital functions such as heart rate and respiration, and has also been linked to basic cognitive components related to arousal and attention. We review the literature from this perspective, and delineate the predictions generated by the hypothesis. In addition, we provide new data showing a link between docosahexaenoic acid and fetal heart rate that is consistent with the hypothesis.
Gustafson
Kathleen M
KM
Hoglund Brain Imaging Center, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA. Kgustafson@kumc.edu
Colombo
John
J
Carlson
Susan E
SE
D000818:Animals; D001143:Arousal; D001288:Attention / Q000502:physiology; D001341:Autonomic Nervous System / Q000502:physiology*; D002462:Cell Membrane / Q000737:chemistry; D003071:Cognition / Q000187:drug effects / Q000502:physiology*; D004281:Docosahexaenoic Acids / Q000378:metabolism / Q000494:pharmacology*; D006339:Heart Rate / Q000502:physiology; D006801:Humans
D004281:Docosahexaenoic Acids