title: Efficacy of atenolol as a single antihypertensive agent in hyperthyroid cats.
abstract: beta-Adrenergic blockers, particularly atenolol, are often recommended for the tachycardia and hypertension that accompany hyperthyroidism; however, the effects of monotherapy with atenolol on both systolic blood pressure (SBP) and heart rate (HR) have not been reported. Twenty hyperthyroid cats with SBP > or = 160 mmHg were studied retrospectively to investigate the SBP and HR lowering effects of atenolol. Median pre-treatment SBP and HR for all cats were 186.5 mmHg and 231 beats/min, respectively. All cats were treated with atenolol at a dosage of 1-2 mg/kg PO q 12h for a minimum of 5 days prior to reassessment and treatment with radioactive iodine. SBP and HR both decreased following atenolol therapy in this group of cats to median values of 171.5 mmHg (P=0.0088) and 185/min (P=0.0003). However, when successful clinical control of hypertension was defined as a post-treatment SBP < 160 mmHg, atenolol monotherapy was ineffective in 70% of the cases. There was no statistically significant difference in baseline serum total thyroxine or atenolol dosage between clinical responders and non-responders. While atenolol effectively reduces HR in most cats with hyperthyroidism, elevated SBP is poorly controlled, and the addition of another vasodilator such as amlodipine or an angiotensin converting enzyme inhibitor is needed to treat associated hypertension.
authors.affiliation: Department of Medical Sciences, University of Wisconsin-Madison School of Veterinary Medicine, 2015 Linden Drive, Madison, WI 53706, United States. henikr@svm.vetmed.wisc.edu
authors.forename: Rosemary A
authors.initials: RA
authors.lastname: Henik
authors.forename: Rebecca L
authors.initials: RL
authors.lastname: Stepien
authors.forename: Lisa J
authors.initials: LJ
authors.lastname: Wenholz
authors.forename: Michele K
authors.initials: MK
authors.lastname: Dolson
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001262:Atenolol / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary*; D006980:Hyperthyroidism / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008297:Male; D012189:Retrospective Studies; D013599:Systole; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D007457:Iodine Radioisotopes; D001262:Atenolol