Detoxification system for inorganic arsenic: transformation of As2O3 into TMAO by vitamin B12 derivatives and conversion of TMAO into arsenobetaine.
A new two-step synthetic pathway developed for the transformation of arsenic trioxide [iAs(III); As(2)O(3)] into arsenobetaine (AB; Me(3)As(+)CH(2)CO(2)(-)) involves treatment of iAs(III) with native B(12) or biomimetic B(12) in the presence of glutathione (GSH) to give TMAO with a high selectivity and a high conversion rate; subsequent treatment of TMAO with iodoacetic acid in the presence of GSH gives arsenobetaine.
Nakamura
Koichiro
K
R & D Department, Nippon Sheet Glass Co., Ltd., Chitose-cho 2, Yokkaichi, Mie, Japan. KoichiroNakamura@mail.nsg.co.jp
Hisaeda
Yoshio
Y
Pan
Ling
L
Yamauchi
Hiroshi
H
D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000737:chemistry*; D032701:Biomimetics; D005978:Glutathione / Q000737:chemistry; D019807:Iodoacetic Acid / Q000737:chemistry; D010087:Oxides / Q000737:chemistry* / Q000633:toxicity; D014805:Vitamin B 12 / Q000737:chemistry*; D014803:Vitamin B Complex / Q000737:chemistry*
D001152:Arsenicals; D010087:Oxides; D014803:Vitamin B Complex; C052920:trimethylarsine oxide; D005978:Glutathione; D014805:Vitamin B 12; D000077237:Arsenic Trioxide; C038992:arsenobetaine; D019807:Iodoacetic Acid