Understanding haemophilic arthropathy: an exploration of current open issues.
Haemophilic arthropathy is joint damage evolving from recurrent joint bleeds that occur in patients suffering from the clotting disorder haemophilia. Insight into the pathogenetic mechanism of this blood-induced arthropathy yields possible treatment targets and modalities useful to reduce this invalidating co-morbidity of haemophilia. Joint bleeding leads to initially independent adverse changes in both the synovial tissue and the articular cartilage. These subsequently influence each other: the synovial inflammatory changes enhancing cartilage damage and vice versa. Consequently, effective treatment strategies will have to affect both pathways.
Jansen
Nathalie W D
NW
Rheumatology & Clinical Immunology, University Medical Center (UMC) Utrecht, Utrecht, The Netherlands. n.w.d.jansen@umcutrecht.nl
Roosendaal
Goris
G
Lafeber
Floris P J G
FP
D001779:Blood Coagulation Factors / Q000627:therapeutic use; D002358:Cartilage, Articular / Q000473:pathology; D006395:Hemarthrosis / Q000473:pathology* / Q000628:therapy; D006467:Hemophilia A / Q000473:pathology / Q000628:therapy; D006801:Humans; D007596:Joints / Q000473:pathology*; D013583:Synovial Membrane / Q000473:pathology
D001779:Blood Coagulation Factors