Toxicity of 3'3-ditrifluormethyldiphenyl diselenide administered during intra-uterine development of rats.
The aim of this study was to assess the effects of the organoselenium compound, 3'3-ditrifluormethyldiphenyl diselenide [(F(3)CPhSe)(2)], during the intra-uterine development of Wistar rats. Dams were given repeated doses of 1, 5 or 10mg/kg (F(3)CPhSe)(2) by intragastric route on gestation days 6-15, and cesarean sections were performed on day 20 of pregnancy. The numbers of implantation sites, living and dead fetuses and resorptions were recorded. Fetuses were weighed and stained with Alizarin red S for skeletal evaluation. The placental morphology was also evaluated. In 1mg/kg (F(3)CPhSe)(2) group, neither maternal toxicity nor prenatal growth retardation was observed. Conversely, in 5 and 10mg/kg groups, there was a decrease in maternal weight gain during pregnancy indicating that (F(3)CPhSe)(2) was maternally toxic, without affecting fetuses weight and length. (F(3)CPhSe)(2) caused some morphological alterations in placenta of 5 and 10mg/kg-exposed dams. Results also showed that skeletal variations were produced by (F(3)CPhSe)(2) only at doses (10mg/kg) in which a marked embryolethality was found. We conclude that (F(3)CPhSe)(2) was toxic to the dams and induced embryofeto-toxicity at doses equal to 10mg/kg.
Weis
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Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, SM, RS, CEP 97105-900 Santa Maria, Brazil.
Roman
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Nogueira
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D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001846:Bone Development / Q000187:drug effects; D001842:Bone and Bones / Q000196:embryology / Q000473:pathology; D004435:Eating / Q000187:drug effects; D005260:Female; D047109:Fetal Development / Q000187:drug effects*; D005333:Fetus / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009929:Organ Size / Q000187:drug effects; D016566:Organoselenium Compounds / Q000633:toxicity*; D010920:Placenta / Q000473:pathology; D011247:Pregnancy; D051381:Rats; D012098:Reproduction / Q000187:drug effects; D014599:Uterus / Q000473:pathology
C517388:3',3-ditrifluoromethyldiphenyl diselenide; D016566:Organoselenium Compounds