title: Synthesis, conformational analysis and biological studies of cyclic cationic antimicrobial peptides containing sugar amino acids.
abstract: Sugar amino acid based 24-membered macrocyclic C2-symmetric cationic peptides were designed and synthesized. The cationic group was introduced in the sugar amino acids. The conformation of these cyclic compounds was ascertained through NMR techniques, which proved they were amphipathic in nature. All the compounds were bacteriolytic, showed good activity against the Gr(+ve) and Gr(-ve) bacteria, and exhibited low hemolytic activity.
authors.affiliation: Indian Institute of Chemical Technology and Centre for Cellular and Molecular Biology, Hyderabad 500607, India. chakraborty@iict.res.in
authors.forename: Tushar Kanti
authors.initials: TK
authors.lastname: Chakraborty
authors.forename: Dipankar
authors.initials: D
authors.lastname: Koley
authors.forename: Rapolu
authors.initials: R
authors.lastname: Ravi
authors.forename: Viswanatha
authors.initials: V
authors.lastname: Krishnakumari
authors.forename: Ramakrishnan
authors.initials: R
authors.lastname: Nagaraj
authors.forename: Ajit Chand
authors.initials: AC
authors.lastname: Kunwar
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D023181:Antimicrobial Cationic Peptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002241:Carbohydrates / Q000737:chemistry*; D002942:Circular Dichroism; D004912:Erythrocytes / Q000187:drug effects / Q000473:pathology; D006461:Hemolysis / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011487:Protein Conformation; D051381:Rats; D014867:Water / Q000737:chemistry
chemical_list: D000596:Amino Acids; D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D002241:Carbohydrates; D010456:Peptides, Cyclic; D014867:Water