title: Synthesis of new triazole-based trifluoromethyl scaffolds.
abstract: Trifluoromethyl propargylamines react with various azide derivatives to afford 1,4-disubstituted 1,2,3-triazoles through a Huisgen 1,3-dipolar cycloaddition. The reaction is catalyzed by a Cu(I) species in acetonitrile, and the corresponding products are obtained in good yields. This process thus offers an entry to new trifluoromethyl peptidomimetics as interesting scaffolds.
authors.affiliation: Laboratoire BioCIS-CNRS, Faculté de Pharmacie, Univ. Paris-Sud, rue J. B. Clément, F-92296 Châtenay-Malabry, France. michela.martinelli1@virgilio.it
authors.forename: Michela
authors.initials: M
authors.lastname: Martinelli
authors.forename: Thierry
authors.initials: T
authors.lastname: Milcent
authors.forename: Sandrine
authors.initials: S
authors.lastname: Ongeri
authors.forename: Benoit
authors.initials: B
authors.lastname: Crousse