Synthesis and evaluation of in vitro antiviral activity of novel phenoxy acetic acid derivatives.
Several substituted phenoxy acetic acid derived pyrazolines were synthesized by the reaction between 2-{4-[3-(2,4-dihydroxyphenyl)-3-oxo-1-propenyl]-2-methoxyphenoxy} acetic acid and substituted acid hydrazides and were tested for their in vitro cytotoxicity and antiviral activity. None of the compounds showed any specific antiviral activity [50% antivirally effective concentration (EC(50)) > or = 5-fold lower than minimum cytotoxic concentration]. The most cytotoxic of the series was 2-{4-[3-(2,4-dihydroxyphenyl)-1-(2-hydroxybenzoyl-4,5-dihydro-1H-5-pyrazolyl]-2-methoxyphenoxy}acetic acid (3(j)), with a minimum cytotoxic concentration of 0.16 microg/mL in human embryonic lung (HEL) cells.
Shahar Yar
M
M
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi, 110062, India. yarmsy@rediffmail.com
Bakht
M Afroz
MA
Siddiqui
A A
AA
Abdullah
M M
MM
De Clercq
Erik
E
D000085:Acetates / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D002460:Cell Line; D006801:Humans; D008168:Lung / Q000166:cytology / Q000196:embryology; D008826:Microbial Sensitivity Tests; D011720:Pyrazoles / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D013329:Structure-Activity Relationship
D000085:Acetates; D000998:Antiviral Agents; D011720:Pyrazoles; C415326:phenoxyacetic acid