Perinatal risk factors and coeliac disease in children and young adults: a record linkage study.
BACKGROUND
Little is known about perinatal risk factors and coeliac disease.


OBJECTIVE
To investigate the relationship between perinatal risk factors and subsequent coeliac disease among offspring.


METHODS
Record linked abstracts of birth registrations, maternity, in-patient and day case records in a defined population of southern England.


RESULTS
Using univariate analysis, coeliac disease in the child was associated with maternal coeliac disease (odds ratio = 20.6; 95% CI = 5.04-84.0; based on two cases in both mother and child) and with social class, year of birth, maternal smoking and parity. Multivariate analysis confirmed an increased risk of coeliac disease of 3.79 (95% CI = 1.85-7.79) for classes IV and V compared with I and II, an increased risk of 1.92 (1.06-3.49) for births during 1975-1979 compared with 1970-1974 and an increased risk of 1.80 (1.05-3.09) for 'subsequent' compared with 'first' births. Smoking during pregnancy was no longer associated with coeliac disease. Because numbers were small, maternal coeliac disease was excluded from the multivariate analysis.


CONCLUSIONS
This study shows increased risks of coeliac disease for manual social classes, births during the late 1970s and 'subsequent' births. Overall, perinatal risk factors seem to have a limited role in the aetiology of coeliac disease in children and young adults.
Roberts
S E
SE
School of Medicine, Swansea University, Swansea, UK. stephen.e.roberts@swansea.ac.uk
Williams
J G
JG
Meddings
D
D
Davidson
R
R
Goldacre
M J
MJ
D000293:Adolescent; D002446:Celiac Disease / Q000453:epidemiology / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008498:Medical Record Linkage / Q000379:methods; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012044:Regression Analysis; D012307:Risk Factors; D012959:Socioeconomic Factors; D055815:Young Adult