Preimplantation genetic screening in a case of recurrent trisomy 21 offspring.
OBJECTIVE
To describe a unique case of recurrent aneuploidy and the use of preimplantation genetic screening (PGS).


METHODS
Case report.


METHODS
Midwest academic medical center.


METHODS
A 36-year-old woman with two trisomy 21 offspring.


METHODS
Preimplantation genetic screening.


METHODS
Karyotype of embryos, liveborn eukaryotic infant.


RESULTS
Preimplantation genetic screening was performed on three cryopreserved embryos, followed by a two-embryo transfer yielding a eukaryotic infant.


CONCLUSIONS
Preimplantation genetic screening may prove to be useful as a diagnostic tool to help ensure a euploid pregnancy when termination is not a viable option for a couple.
Hudson
Susan B A
SB
Division of Reproductive Endocrinology and Infertility, Mayo Clinic, Rochester, Minnesota 55905, USA. hudson.susan@mayo.edu
Coddington
Charles C
CC
Walker
David L
DL
Fredrickson
Jolene R
JR
Morbeck
Dean E
DE
D000328:Adult; D015925:Cryopreservation; D004314:Down Syndrome / Q000175:diagnosis* / Q000235:genetics; D004624:Embryo Transfer; D004622:Embryo, Mammalian; D005260:Female; D005820:Genetic Testing; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D050498:Live Birth; D011247:Pregnancy; D019836:Preimplantation Diagnosis