title: Genetic characterization of measles viruses in China, 2004.
abstract: Genetic characterization of wild-type measles virus was studied using nucleotide sequencing of the C-terminal region of the N protein gene and phylogenetic analysis on 59 isolates from 16 provinces of China in 2004. The results showed that all of the isolates belonged to genotype H1. 51 isolates were belonged to cluster 1 and 8 isolates were cluster 2 and Viruses from both clusters were distributed throughout China without distinct geographic pattern. The nucleotide sequence and predicted amino acid homologies of the 59 H1 strains were 96.5%-100% and 95.7%-100%, respectively. The report showed that the transmission pattern of genotype H1 viruses in China in 2004 was consistent with ongoing endemic transmission of multiple lineages of a single, endemic genotype. Multiple transmission pathways leaded to multiple lineages within endemic genotype.
authors.affiliation: WHO WPRO Regional Reference Measles Lab, National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Beijing 100050, PR China. zhangyanft@hotmail.com
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yixin
authors.initials: Y
authors.lastname: Ji
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Jiang
authors.forename: Songtao
authors.initials: S
authors.lastname: Xu
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhu
authors.forename: Lei
authors.initials: L
authors.lastname: Zheng
authors.forename: Jilan
authors.initials: J
authors.lastname: He
authors.forename: Hua
authors.initials: H
authors.lastname: Ling
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Wen
authors.initials: W
authors.lastname: Du
authors.forename: Xuelei
authors.initials: X
authors.lastname: Yang
authors.forename: Naiying
authors.initials: N
authors.lastname: Mao
authors.forename: Wenbo
authors.initials: W
authors.lastname: Xu
mesh_terms: D002681:China / Q000453:epidemiology; D016000:Cluster Analysis; D019353:Endemic Diseases; D006801:Humans; D008457:Measles / Q000453:epidemiology* / Q000635:transmission / Q000821:virology*; D008459:Measles virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D019590:Nucleocapsid Proteins; D009698:Nucleoproteins / Q000235:genetics; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D014764:Viral Proteins / Q000235:genetics
chemical_list: D019590:Nucleocapsid Proteins; D009698:Nucleoproteins; D014764:Viral Proteins; C058314:nucleoprotein, Measles virus