Regulation of phospholipid synthesis in yeast.
Phospholipid synthesis in the yeast Saccharomyces cerevisiae is a complex process that involves regulation by both genetic and biochemical mechanisms. The activity levels of phospholipid synthesis enzymes are controlled by gene expression (e.g., transcription) and by factors (lipids, water-soluble phospholipid precursors and products, and covalent modification of phosphorylation) that modulate catalysis. Phosphatidic acid, whose levels are controlled by the biochemical regulation of key phospholipid synthesis enzymes, plays a central role in the regulation of phospholipid synthesis gene expression.
Carman
George M
GM
Department of Food Science and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ 08901, USA. carman@aesop.rutgers.edu
Han
Gil-Soo
GS
D019852:Diacylglycerol Kinase / Q000378:metabolism; D007294:Inositol / Q000378:metabolism; D010712:Phosphatidic Acids / Q000378:metabolism; D010743:Phospholipids / Q000096:biosynthesis*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D015032:Zinc / Q000378:metabolism
D010712:Phosphatidic Acids; D010743:Phospholipids; D007294:Inositol; D019852:Diacylglycerol Kinase; D015032:Zinc