The plastidial MEP pathway: unified nomenclature and resources.
In plants, the plastid-localized 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway provides the precursors for the synthesis of isoprenoid hormones, monoterpenes, carotenoids and the side chain of chlorophylls, tocopherols and prenylquinones. As a result of the fast progress in the elucidation and characterization of the pathway (mainly by genetic approaches in Escherichia coli and Arabidopsis thaliana), different names have been used in the literature to designate the orthologous bacterial and plant genes and the corresponding null and partial loss-of-function mutants. This has led to a confusing variety of naming conventions in this field. Here, we propose a reorganization of the various naming systems with the aim of facilitating the dissemination and sharing of genetic resources and tools central to plant isoprenoid research.
Phillips
Michael A
MA
Departament de Genètica Molecular Vegetal, Centre de Recerca en Agrogenòmica (CRAG CSIC-IRTA-UAB), C/Jordi Girona 18, 08034 Barcelona, Spain.
León
Patricia
P
Boronat
Albert
A
Rodríguez-Concepción
Manuel
M
D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism*; D053898:Biosynthetic Pathways / Q000235:genetics; D004896:Erythritol / Q000031:analogs & derivatives* / Q000378:metabolism; D005798:Genes, Bacterial; D009154:Mutation; D018087:Plastids / Q000378:metabolism*; D013403:Sugar Phosphates / Q000378:metabolism*; D009626:Terminology as Topic; D013729:Terpenes / Q000378:metabolism*
C114232:2-C-methylerythritol 4-phosphate; D013403:Sugar Phosphates; D013729:Terpenes; D004896:Erythritol