title: Otologic manifestations in Samter's syndrome.
abstract: OBJECTIVE
  It was the aim of this study to investigate the prevalence of otologic manifestations in a cohort of Samter's syndrome patients (nasal polyps with chronic rhinosinusitis, aspirin intolerance and asthma).
  
  
  METHODS
  We analyzed a retrospective and prospective case review from 1995 to 2005, performed in the otorhinolaryngology outpatient clinic of a tertiary referral center. Ear history, clinical examinations, treatment and outcome were evaluated using office and hospital records in 23 cases. All subjects completed a questionnaire.
  
  
  RESULTS
  In 6 cases (26%), otological manifestations with ear pressure and conductive hearing loss occurred during an advanced stage of Samter's syndrome (>5 years after onset of the first nasal symptoms) partially responsive to systemic steroids.
  
  
  CONCLUSIONS
  Recognition of the association between Samter's syndrome and otological disease is important (26% of the cases) because it could also be responsive to systemic steroids which prevent progression to irreversible hearing loss or infectious otomastoiditis.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital, University of Bern, Bern, Switzerland. marco.caversaccio@insel.ch
authors.forename: Marco
authors.initials: M
authors.lastname: Caversaccio
authors.forename: Rudolf
authors.initials: R
authors.lastname: Häusler
authors.forename: Arthur
authors.initials: A
authors.lastname: Helbling
mesh_terms: D001241:Aspirin / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced / Q000150:complications*; D002908:Chronic Disease; D015331:Cohort Studies; D004342:Drug Hypersensitivity / Q000150:complications; D004427:Ear Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D004432:Ear, Middle / Q000473:pathology; D005064:Eustachian Tube / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008416:Mastoid / Q000000981:diagnostic imaging; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology; D009298:Nasal Polyps / Q000139:chemically induced / Q000150:complications*; D011127:Polyps / Q000473:pathology; D011446:Prospective Studies; D011859:Radiography; D012189:Retrospective Studies; D012220:Rhinitis / Q000139:chemically induced / Q000150:complications*; D012852:Sinusitis / Q000139:chemically induced / Q000150:complications*; D013577:Syndrome; D013701:Temporal Bone / Q000000981:diagnostic imaging
chemical_list: D001241:Aspirin