title: Leg ulcers: a new symptom of Blau syndrome?
abstract: Blau syndrome is a rare autosomal dominant condition, typically defined by granulomatous polyarthritis, uveitis and skin eruption. Biopsy specimens demonstrate non-caseating granulomas in all lesions. We present a case of Blau syndrome associated with large recalcitrant leg ulcers. Biopsies taken in the leg ulcers of our patient systematically showed granulomas. Although leg ulcers have not previously been described as a part of Blau syndrome, we assume that the ulcerations in this case form part of Blau syndrome.
authors.affiliation: Department of Dermatology, University Hospital of Ghent, De Pintelaan 185, 9000 Ghent, Belgium. veerle.dhondt@ugent.be
authors.forename: Veerle
authors.initials: V
authors.lastname: Dhondt
authors.forename: Sarah
authors.initials: S
authors.lastname: Hofman
authors.forename: Karin
authors.initials: K
authors.lastname: Dahan
authors.forename: Hilde
authors.initials: H
authors.lastname: Beele
mesh_terms: D001168:Arthritis / Q000150:complications; D006099:Granuloma / Q000473:pathology*; D006801:Humans; D007871:Leg Ulcer / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D053473:Nod2 Signaling Adaptor Protein / Q000235:genetics; D012873:Skin Diseases, Genetic / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D013577:Syndrome
chemical_list: D053473:Nod2 Signaling Adaptor Protein