Trypanosoma cruzi: a stage-specific calpain-like protein is induced after various kinds of stress.
Calpains are calcium-dependent cysteine proteinases found in all living organisms and are involved in diverse cellular processes. Calpain-like proteins have been reported after in silico analysis of the Tritryps genome and are believed to play important roles in cell functions of trypanosomatids. We describe the characterization of a member of this family, which is differentially expressed during the life-cycle of Trypanosoma cruzi.
Giese
Viviane
V
Instituto Carlos Chagas-Fiocruz, Curitiba, PR, Brasil.
Dallagiovanna
Bruno
B
Marchini
Fabricio K
FK
Pavoni
Daniela P
DP
Krieger
Marco A
MA
Goldenberg
Samuel
S
D000818:Animals; D015153:Blotting, Western; D002154:Calpain / Q000096:biosynthesis* / Q000235:genetics; D008018:Life Cycle Stages / Q000235:genetics* / Q000502:physiology; D016133:Polymerase Chain Reaction; D015800:Protozoan Proteins / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D014349:Trypanosoma cruzi / Q000235:genetics / Q000254:growth & development*
D015800:Protozoan Proteins; D012333:RNA, Messenger; C540143:CALPx11 protein, Trypanosoma cruzi; D002154:Calpain