title: Carbon-fluorine bond formation.
abstract: A selection of carbon-fluorine bond-forming reactions that have been developed in the recent past are presented. An overview of the most common fluorination reagents is followed by descriptions of fluorination reactions that are organized by reactivity. The distinction between nucleophilic and electrophilic fluorinations is highlighted, as well as between aliphatic and aromatic fluorinations. Each section is divided into more specific reaction classes and examples for the synthesis of pharmaceuticals, [18F]radiolabeling and mechanistic investigations are provided.
authors.affiliation: Harvard University, Department of Chemistry and Chemical Biology, 12 Oxford Street, Cambridge, MA 02138, USA.
authors.forename: Takeru
authors.initials: T
authors.lastname: Furuya
authors.forename: Christian A
authors.initials: CA
authors.lastname: Kuttruff
authors.forename: Tobias
authors.initials: T
authors.lastname: Ritter
mesh_terms: D002244:Carbon / Q000737:chemistry*; D054879:Halogenation; D013237:Stereoisomerism
chemical_list: D002244:Carbon