Lipid apheresis applications in childhood: experience in the University Hospital of Gazi.
The most commonly encountered complications in familial hypercholesterolemia (FH) are mainly cardiovascular in origin and the majority of cases unfortunately die due to this problem. LDL-apheresis is a proven therapeutic method in lowering this mortal risk. In this study we aimed to demonstrate the efficiency of LDL-apheresis performed by DALI or Cascade filtration on four pediatric patients with the diagnosis of homozygous FH. Applied LDL-apheresis techniques, side effects, laboratory results and cardiovascular follow-up are discussed in the light of current literature. Our study has shown once again that lipid apheresis treatment in children with homozygous FH is the most effective treatment. The number of childhood subjects in whom lipid apheresis is performed is quite insufficient. There are no studies that compare DALI with cascade filtration in childhood subjects in our knowledge. The view of this aspect, this study will contribute to literature.
Eminoglu
Tuba F
TF
Department of Pediatric Metabolism and Nutrition, Gazi University, Ankara, Turkey.
Yenicesu
Idil
I
Tumer
Leyla
L
Okur
Ilyas
I
Dilsiz
Günter
G
Hasanoglu
Alev
A
D000293:Adolescent; D001781:Blood Component Removal; D002648:Child; D005260:Female; D006720:Homozygote; D006785:Hospitals, University; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000175:diagnosis / Q000235:genetics / Q000628:therapy*; D008077:Lipoproteins, LDL; D012189:Retrospective Studies; D014421:Turkey
D008077:Lipoproteins, LDL