Neutrophil chemokines GCP-2 and GRO-alpha in patients with inflammatory bowel disease.
OBJECTIVE
To measure the serum levels of neutrophils chemokine granulocyte chemotactic protein-2 (GCP-2) and interleukin-8 (IL-8) in Crohn's disease (CD) and ulcerative colitis (UC) patients and compare them with serum levels of growth-related oncogene (GRO-alpha).


METHODS
Forty-two patients with inflammatory bowel disease (24 CD and 18 UC) and 38 matched healthy subjects were recruited. Their serum GCP-2, IL-8 and GRO-alpha were measured by a specific enzyme immunoassay kit.


RESULTS
The serum levels of GCP-2 were significantly higher in the CD than the UC patients but lower than in the healthy subjects. The GCP-2 in the UC patients were significantly lower than in the healthy subjects. The GRO-alpha levels were significantly higher in the IBD patients than in the healthy subjects. The IL-8 levels were under the detectable limit in both the IBD and the healthy subjects.


CONCLUSIONS
In this group of patients, GCP-2 did not participate in the inflammatory response in IBD. GRO-alpha could be an important factor that enhances the inflammatory state in IBD.
Alzoghaibi
Mohammed A
MA
Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia. zzoghaibi@hotmail.com
Al-Mofleh
Ibramim A
IA
Al-Jebreen
Abdulrhman M
AM
D000328:Adult; D054360:Chemokine CXCL1 / Q000097:blood*; D054427:Chemokine CXCL6 / Q000097:blood*; D003093:Colitis, Ulcerative / Q000097:blood* / Q000276:immunology; D003424:Crohn Disease / Q000097:blood* / Q000276:immunology; D006801:Humans; D007124:Immunoenzyme Techniques; D016209:Interleukin-8 / Q000097:blood*
D054360:Chemokine CXCL1; D054427:Chemokine CXCL6; D016209:Interleukin-8