[Receptors for advanced glycation end products and their physiological and clinical significance].
The receptor for advanced glycation end products (RAGE) is a multiligand cell-surface protein and belongs to the immunoglobulin superfamily. RAGE is expressed by different cell types, including macrophages, lymphocytes, endothelial, neuronal, and smooth muscle cells. In addition to advanced glycation end products (AGEs), RAGE binds amphoterin, S100/calgranulin, amyloid, transthyretin, and a leukocyte integrin, Mac-1. Engagement of RAGE in intracellular signaling leads to the activation of the proinflammatory transcription factor NF-kappaB to sustained cellular dysfunction and tissue destruction. In this study a pivotal role of RAGE in the progression of various diseases, i.e. diabetes, inflammation, neurodegeneration, tumors, vascular injury, atherosclerosis, and septic shock, is presented.
Pietkiewicz
Jadwiga
J
Katedra i Zakład Biochemii Lekarskiej, Akademia Medyczna we Wrocławiu, Wrocław. egdn@bioch.am.wroc.pl
Seweryn
Ewa
E
Bartyś
Arkadiusz
A
Gamian
Andrzej
A
D000818:Animals; D050197:Atherosclerosis / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D003920:Diabetes Mellitus / Q000378:metabolism; D018450:Disease Progression; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000378:metabolism*; D012772:Shock, Septic / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases; D014652:Vascular Diseases / Q000378:metabolism
D004268:DNA-Binding Proteins; D017127:Glycation End Products, Advanced; D009419:Nerve Tissue Proteins; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic; C094800:Pja2 protein, rat; D044767:Ubiquitin-Protein Ligases