Highly enantioselective aza-Henry reaction of ketoimines catalyzed by chiral N,N'-dioxide-copper(I) complexes.
The first example of catalytic enantioselective aza-Henry reaction of ketoimines has been realized using a simple chiral N,N'-dioxide-Cu(I) complex as catalyst. It performs well over a range of substrates to give the corresponding products in moderate to good yields (up to 83%) with high enantioselectivities (up to 96% ee).
Tan
Cheng
C
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, PR China.
Liu
Xiaohua
X
Wang
Liwei
L
Wang
Jun
J
Feng
Xiaoming
X
D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D009585:Nitrogen Dioxide / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
D007097:Imines; D003300:Copper; D009585:Nitrogen Dioxide