Wnt signaling: relevance to beta-cell biology and diabetes.
Interest in the importance of Wnt signaling in diabetes has risen after identification of the transcription factor TCF7L2, a component of this pathway, as a strong risk factor for type 2 diabetes. Here, we review emerging new evidence that Wnt signaling influences endocrine pancreas development and modulates mature beta-cell functions including insulin secretion, survival and proliferation. Alterations in Wnt signaling might also impact other metabolic tissues involved in the pathogenesis of diabetes, with TCF7L2 proposed to modulate adipogenesis and regulate GLP-1 production. Together, these studies point towards a role for Wnt signaling in the pathogenesis of type 2 diabetes, highlighting the importance of further investigation of this pathway to develop new therapies for this disease.
Welters
Hannah J
HJ
Joslin Diabetes Center and Department of Medicine, Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA. hannah.welters@joslin.harvard.edu
Kulkarni
Rohit N
RN
D050156:Adipogenesis / Q000502:physiology; D000818:Animals; D049109:Cell Proliferation; D002470:Cell Survival / Q000502:physiology; D003920:Diabetes Mellitus / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D050417:Insulin-Secreting Cells / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D010179:Pancreas / Q000254:growth & development / Q000378:metabolism / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D051153:Wnt Proteins / Q000378:metabolism / Q000502:physiology*
D051153:Wnt Proteins