title: A role for Th17 cells in the immunopathogenesis of atopic dermatitis?
abstract: Atopic dermatitis (AD) is a common inflammatory skin disease. Both epidermal barrier dysfunction and immunodysregulation are suggested to influence the pathogenesis of AD. AD has been considered a paradigmatic T helper cell (Th) 2-mediated disease, with a switch to a Th1 cell environment during the chronic phase of the disease. Previously unreported findings now suggest a possible role for Th17 cells as well.
authors.affiliation: St. John's Institute of Dermatology, King's College London School of Medicine and NIHR Biomedical Research Centre, London, United Kingdom; Department of Dermatology, University of L'Aquila L'Aquila, Italy.
authors.forename: Antonella Di
authors.initials: AD
authors.lastname: Cesare
authors.affiliation: St. John's Institute of Dermatology, King's College London School of Medicine and NIHR Biomedical Research Centre, London, United Kingdom.
authors.forename: Paola Di
authors.initials: PD
authors.lastname: Meglio
authors.affiliation: St. John's Institute of Dermatology, King's College London School of Medicine and NIHR Biomedical Research Centre, London, United Kingdom. Electronic address: frank.nestle@kcl.ac.uk.
authors.forename: Frank O
authors.initials: FO
authors.lastname: Nestle
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D003876:Dermatitis, Atopic / Q000209:etiology* / Q000276:immunology*; D018450:Disease Progression; D006801:Humans; D020381:Interleukin-17 / Q000378:metabolism*; D012720:Severity of Illness Index; D006377:T-Lymphocytes, Helper-Inducer / Q000378:metabolism*; D018417:Th1 Cells / Q000378:metabolism; D018418:Th2 Cells / Q000378:metabolism
chemical_list: D020381:Interleukin-17