title: Successful surgical management of giant condyloma acuminatum (Buschke-Löwenstein tumor) in the genitoanal region: a case report and evaluation of current therapies.
abstract: Giant condyloma acuminatum (GCA; Buschke-Lowenstein tumor) is a human-papillomavirus-induced cauliflower-like tumor of the genitoanal region. It is characterized by its size, capability of local infiltration and high recurrence rate. We report on a 50-year-old patient presenting with a maximum finding of GCA with deep infiltration into the adductor and perineal musculature, the scrotum, the penis and the para-rectum. After performing a temporary loop colostomy, the tumor was removed by wide radical excision following plastic reconstruction with a myocutaneous gracilis flap. During a follow-up period of more than 5 years, no recurrence developed. Many treatment strategies (e.g. chemotherapy, radiation) have been published in the literature. Most authors recommend the radical surgical excision, allowing a complete histological examination and assessment of tumor-free resection margins. Despite the benign histological pattern of GCA in most cases, transformations into verrucous carcinoma and squamous-cell carcinoma have been described. In our case, the GCA seems to represent a continuum between normal condyloma acuminatum and an initial verrucous carcinoma.
authors.affiliation: Department of Dermatology, University of Heidelberg, Heidelberg, Germany. patrick.gholam@med.uni-heidelberg.de
authors.forename: P
authors.initials: P
authors.lastname: Gholam
authors.forename: A
authors.initials: A
authors.lastname: Enk
authors.forename: W
authors.initials: W
authors.lastname: Hartschuh
mesh_terms: D001005:Anus Neoplasms / Q000473:pathology / Q000601:surgery* / Q000821:virology; D003218:Condylomata Acuminata / Q000473:pathology / Q000601:surgery* / Q000821:virology; D052163:Human papillomavirus 6 / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000473:pathology / Q000601:surgery* / Q000821:virology; D010412:Penile Neoplasms / Q000473:pathology / Q000601:surgery* / Q000821:virology; D012867:Skin / Q000473:pathology; D013524:Surgical Flaps; D016896:Treatment Outcome; D013521:Urologic Surgical Procedures, Male