[Atrial fibrillation and the autonomous nervous system].
The autonomic nervous system has a crucial role in the genesis, maintenance and abruption of atrial fibrillation. The substrate and trigger mechanism of atrial fibrillation can be influenced by the changing autonomic tone. The authors summarize the current knowledge on the relationship between autonomic nervous system and atrial fibrillation. The special neuroanatomical status and the role of autonomic reflexes and baroreflex in the initiation, maintenance, and termination of arrhythmia are reviewed. Furthermore, the mechanism and consequences of autonomic effect of the curative radiofrequency catheter ablation of pulmonary vein with atrial vagal neuroablation are discussed. At the end we also summarize the pharmacologic therapy of atrial fibrillation. Classification of atrial fibrillation, as either vagal or adrenergic, has only limited impact on current management.
Lorincz
István
I
Debreceni Egyetem, Orvos- és Egészségtudományi Centrum, Altalános Orvostudományi Kar Belgyógyászati Intézet, I. Belgyógyászati Klinika, Sürgosségi Orvostan Tanszék, Debrecen Nagyerdei krt. 98. Pf. 19. 4032. lorincz@internal.med.unideb.hu
Szabó
Zoltán
Z
Simkó
József
J
Szánthó
Eszter
E
Barta
Kitti
K
Füzi
Márta
M
Szigeti
Gyula
G
D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000188:drug therapy / Q000503:physiopathology* / Q000601:surgery / Q000628:therapy*; D001341:Autonomic Nervous System / Q000187:drug effects / Q000503:physiopathology*; D017704:Baroreflex; D017115:Catheter Ablation; D004554:Electric Countershock; D006801:Humans; D011667:Pulmonary Veins / Q000601:surgery; D014630:Vagus Nerve / Q000601:surgery
D000889:Anti-Arrhythmia Agents