Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.
Population-based allele frequencies and genotype prevalence are important for measuring the contribution of genetic variation to human disease susceptibility, progression, and outcomes. Population-based prevalence estimates also provide the basis for epidemiologic studies of gene-disease associations, for estimating population attributable risk, and for informing health policy and clinical and public health practice. However, such prevalence estimates for genotypes important to public health remain undetermined for the major racial and ethnic groups in the US population. DNA was collected from 7,159 participants aged 12 years or older in Phase 2 (1991-1994) of the Third National Health and Nutrition Examination Survey (NHANES III). Certain age and minority groups were oversampled in this weighted, population-based US survey. Estimates of allele frequency and genotype prevalence for 90 variants in 50 genes chosen for their potential public health significance were calculated by age, sex, and race/ethnicity among non-Hispanic whites, non-Hispanic blacks, and Mexican Americans. These nationally representative data on allele frequency and genotype prevalence provide a valuable resource for future epidemiologic studies in public health in the United States.
Chang
Man-Huei
MH
National Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA. mdc9@cdc.gov
Lindegren
Mary Lou
ML
Butler
Mary A
MA
Chanock
Stephen J
SJ
Dowling
Nicole F
NF
Gallagher
Margaret
M
Moonesinghe
Ramal
R
Moore
Cynthia A
CA
Ned
Renée M
RM
Reichler
Mary R
MR
Sanders
Christopher L
CL
Welch
Robert
R
Yesupriya
Ajay
A
Khoury
Muin J
MJ
D000293:Adolescent; D000328:Adult; D001741:Black or African American / Q000235:genetics; D002648:Child; D003430:Cross-Sectional Studies; D004247:DNA / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D008297:Male; D017058:Mexican Americans / Q000235:genetics; D008875:Middle Aged; D009749:Nutrition Surveys; D011110:Polymorphism, Genetic; D014481:United States / Q000453:epidemiology; D044465:White People / Q000235:genetics
D004247:DNA