title: Nanocrystal core high-density lipoproteins: a multimodality contrast agent platform.
abstract: High density lipoprotein (HDL) is an important natural nanoparticle that may be modified for biomedical imaging purposes. Here we developed a novel technique to create unique multimodality HDL mimicking nanoparticles by incorporation of gold, iron oxide, or quantum dot nanocrystals for computed tomography, magnetic resonance, and fluorescence imaging, respectively. By including additional labels in the corona of the particles, they were made multifunctional. The characteristics of these nanoparticles, as well as their in vitro and in vivo behavior, revealed that they closely mimic native HDL.
authors.affiliation: Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1234, New York, New York 10029, USA.
authors.forename: David P
authors.initials: DP
authors.lastname: Cormode
authors.forename: Torjus
authors.initials: T
authors.lastname: Skajaa
authors.forename: Matti M
authors.initials: MM
authors.lastname: van Schooneveld
authors.forename: Rolf
authors.initials: R
authors.lastname: Koole
authors.forename: Peter
authors.initials: P
authors.lastname: Jarzyna
authors.forename: Mark E
authors.initials: ME
authors.lastname: Lobatto
authors.forename: Claudia
authors.initials: C
authors.lastname: Calcagno
authors.forename: Alessandra
authors.initials: A
authors.lastname: Barazza
authors.forename: Ronald E
authors.initials: RE
authors.lastname: Gordon
authors.forename: Pat
authors.initials: P
authors.lastname: Zanzonico
authors.forename: Edward A
authors.initials: EA
authors.lastname: Fisher
authors.forename: Zahi A
authors.initials: ZA
authors.lastname: Fayad
authors.forename: Willem J M
authors.initials: WJ
authors.lastname: Mulder
mesh_terms: D000818:Animals; D002460:Cell Line; D003287:Contrast Media / Q000737:chemistry*; D006046:Gold / Q000737:chemistry; D008075:Lipoproteins, HDL / Q000737:chemistry* / Q000648:ultrastructure; D008264:Macrophages / Q000648:ultrastructure; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D051379:Mice; D046529:Microscopy, Electron, Transmission
chemical_list: D003287:Contrast Media; D008075:Lipoproteins, HDL; D006046:Gold