title: Surgical resection versus palliative chemoradiotherapy for the management of pancreatic cancer with local venous invasion: a decision analysis.
abstract: BACKGROUND
  Benefit from pancreaticoduodenectomy (PD) combined with superior mesenteric-portal vein (SMV-PV) resection in the management of pancreatic adenocarcinoma with local venous invasion remains controversial.
  
  
  METHODS
  Using formal decision analysis, we compared survival associated with PD plus SMV-PV resection when applied to patients with pancreatic adenocarcinoma with isolated local venous invasion (Group 1) versus that achieved with palliative chemoradiotherapy when applied to patients with locally advanced pancreatic cancer (Group 2). Individual studies were identified using Medline. A total of 1,324 and 709 patients were analyzed for Groups 1 and 2, respectively. Patients with distant metastases were excluded.
  
  
  RESULTS
  Overall decision analysis favored surgical resection (Group 1) over palliative chemoradiotherapy (Group 2). Sensitivity analyses indicated that this decision is sensitive to the perioperative mortality rate and the percentage of surgical resections with microscopic (R1) or macroscopic (R2) residual tumor at the resection margin. In contrast, sensitivity analysis revealed that the decision is not sensitive to the percentage of cases in which true venous invasion by cancer is documented histologically.
  
  
  CONCLUSIONS
  Surgical resection may confer a survival advantage over palliative chemoradiotherapy in select patients with pancreatic cancers with presumed local venous invasion.
authors.affiliation: Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Abramson
authors.forename: Edward W
authors.initials: EW
authors.lastname: Swanson
authors.forename: Edward E
authors.initials: EE
authors.lastname: Whang
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003661:Decision Support Techniques; D006801:Humans; D009361:Neoplasm Invasiveness; D010166:Palliative Care / Q000379:methods*; D010180:Pancreatectomy / Q000379:methods*; D010190:Pancreatic Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D018714:Radiotherapy, Adjuvant; D015996:Survival Rate / Q000639:trends; D014481:United States / Q000453:epidemiology; D019043:Vascular Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D014680:Veins / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents