[Correlation of C-reactive protein with echocardiographic parameters of hypertrophic and ischemic heart disease in patients on regular hemodialyses].
BACKGROUND
Cardiovascular diseases are the most frequent cause of morbidity and mortality in patients on hemodialysis. The reason for this is a high prevailance of risk factors for the development of cardiovascular complications with these patients. Microinflammation is one of the risk factors for the development of atherosclerosis of coronary arteries in patients on hemodialysis. The study was aimed at investigating correlation between microinflammation parameter C-reactive protein (CRP) and echocardiographic parameters of left ventricular hypertrophy and left ventricular dilatation (left ventricular mass index-LVMi, left ventricular end-diastolic volume index-EDVi) and echocardiographic parameters of ischemic heart disease and systolic function (systolic thickness of interventricular septum-StIVS, systolic thickness of left ventricular posterior wall-StPWLV, amplitude of motion of interventricular septum-AmmIVS, amplitude of motion of left ventricular posterior wall-AmmPWLV, left ventricular fractional shortening-LVFS, left ventricular ejectional fraction-LVEF).


METHODS
The research was conducted on 115 patients (M:F 7/:44) regularly treated by hemodialysis, average age 53.30+/-12.17 years, average length of dialysis 4.51+/-4.01 years and average Kt/Vsp index 1.17+/-0.23.


RESULTS
Average CRP was 7.50+/-9.34 mg/l, EDVi 100.80+/-34.62 ml/m2, StPWLV 54.17+/-14.03%, and AmmPWLV 6.09+/-1.58 mm. Statistically significant positive correlation between serum concentration CRP and EDVi (p=0.221) was found. Highly statistically important significant negative correlation was proved between the serum CRP concentration and StPWLV (p=-0.249) and AmmPWLV (p=-0.289).


CONCLUSIONS
Microinflammation is a possible risk factor for the development of atherosclerosis of coronary artheries in patients on hemodialysis.
Petrović
Dejan
D
Klinika za urologiju i nefrologiju, Odeljenje hemodijalize, Klinicki centar Kragujevac, Kragujevac. aca96@eunet.yu
Obrenović
Radmila
R
Poskurica
Mileta
M
Stojimirović
Biljana
B
D002097:C-Reactive Protein / Q000032:analysis*; D004452:Echocardiography; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology; D007249:Inflammation; D018836:Inflammation Mediators / Q000097:blood; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000150:complications; D006435:Renal Dialysis; D013318:Stroke Volume; D016277:Ventricular Function, Left
D018836:Inflammation Mediators; D002097:C-Reactive Protein