title: Modeling nutrient fluxes and plasma ketone bodies in periparturient cows.
abstract: A mechanistic model was developed to study the interrelationship between glucose and lipid metabolism in periparturient cows. The driving variables were dry matter intake, feed composition, calf birth weight, milk production, and milk components. The response variables were body fat content and concentrations of plasma glucose, glycerol, nonesterified fatty acids (NEFA), and total ketone bodies (KB). Fetal growth and milk synthesis were assigned the highest priority for glucose demand in the model. The rate of fat mobilization was expressed as a function of glucose deficiency. The model assumed first-order kinetics for utilization of NEFA and KB. Model prediction errors were 19, 43, 48, and 36% of mean predictions for glucose, glycerol, NEFA, and KB, respectively. A linear bias was observed in KB and glycerol predictions. The model may be useful for understanding and explaining ketosis development.
authors.affiliation: Department of Animal and Avian Sciences, University of Maryland, College Park 20742, USA.
authors.forename: J
authors.initials: J
authors.lastname: Guo
authors.forename: R R
authors.initials: RR
authors.lastname: Peters
authors.forename: R A
authors.initials: RA
authors.lastname: Kohn
mesh_terms: D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D002417:Cattle / Q000378:metabolism*; D002418:Cattle Diseases / Q000097:blood / Q000517:prevention & control; D005260:Female; D005947:Glucose / Q000378:metabolism; D005990:Glycerol / Q000378:metabolism; D007657:Ketone Bodies / Q000097:blood*; D007662:Ketosis / Q000097:blood / Q000517:prevention & control / Q000662:veterinary; D008954:Models, Biological; D049590:Postpartum Period; D011247:Pregnancy; D013997:Time Factors
chemical_list: D007657:Ketone Bodies; D005947:Glucose; D005990:Glycerol