title: Hepcidin regulation of iron transport.
abstract: The discovery of hepcidin as a key regulator of iron homeostasis has advanced our current knowledge of this field. Liver-derived hepcidin peptide is secreted in response to iron and inflammation and interacts with the iron export protein ferroportin. This review summarizes recent advances discussed at the Symposium. A particular focus is on molecular interactions between hepcidin and ferroportin, the regulation of hepcidin expression by iron and inflammation, and emerging methods to measure serum hepcidin in human populations.
authors.affiliation: Department of Exercise and Nutrition Sciences, University at Buffalo, the State University of New York, Buffalo, NY 14214, USA.
authors.forename: James F
authors.initials: JF
authors.lastname: Collins
authors.forename: Marianne
authors.initials: M
authors.lastname: Wessling-Resnick
authors.forename: Mitchell D
authors.initials: MD
authors.lastname: Knutson
mesh_terms: D023181:Antimicrobial Cationic Peptides / Q000235:genetics / Q000378:metabolism*; D001692:Biological Transport / Q000502:physiology; D005786:Gene Expression Regulation; D064451:Hepcidins; D006706:Homeostasis; D006801:Humans; D007501:Iron / Q000378:metabolism*
chemical_list: D023181:Antimicrobial Cationic Peptides; C578702:HAMP protein, human; D064451:Hepcidins; D007501:Iron