title: Prevalence of vertebral fractures in children with chronic rheumatic diseases at risk for osteopenia.
abstract: OBJECTIVE
  To determine the prevalence of and the risk factors for vertebral fractures in a cohort of children with chronic rheumatic diseases considered at risk for osteopenia.
  
  
  METHODS
  We conducted a cross-sectional study of patients with chronic rheumatic diseases at the Montreal Children's Hospital.
  
  
  RESULTS
  Of the 90 study participants (22 boys, 68 girls), 10 boys and 7 girls (19%) were found to have vertebral fractures. These 17 children had a total of 50 fractures, an average of 2.9 per affected child. Fractures in the upper thoracic region (T5-8) accounted for 55%. Only 56% of all fractures were symptomatic. With multivariate regression, we identified male sex (P < .01), body mass index z-score (P < .02), and cumulative glucocorticoid dose (P < .01) as significant predictors of the number of vertebral fractures.
  
  
  CONCLUSIONS
  Our study examined the prevalence of vertebral fractures in a high-risk pediatric population. Nineteen percent of our cohort had vertebral fractures. Significant risk factors for the development of vertebral fractures include male sex and cumulative glucocorticoid dose. Better understanding of the extent of the problem in this population will allow us to further refine screening guidelines and treatment in these patients.
authors.affiliation: Division of Endocrinology, Montreal Children's Hospital, McGill University Health Centre, Quebec, Canada. nakhlam@yahoo.com
authors.forename: Meranda
authors.initials: M
authors.lastname: Nakhla
authors.forename: Rosie
authors.initials: R
authors.lastname: Scuccimarri
authors.forename: Karen N Watanabe
authors.initials: KN
authors.lastname: Duffy
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Chédeville
authors.forename: Sarah
authors.initials: S
authors.lastname: Campillo
authors.forename: Ciarán M
authors.initials: CM
authors.lastname: Duffy
authors.forename: E Michel
authors.initials: EM
authors.lastname: Azouz
authors.forename: Nazih
authors.initials: N
authors.lastname: Shenouda
authors.forename: Atul K
authors.initials: AK
authors.lastname: Sharma
authors.forename: Celia
authors.initials: C
authors.lastname: Rodd
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D001851:Bone Diseases, Metabolic / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006776:Hospitals, Pediatric / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D015995:Prevalence; D012216:Rheumatic Diseases / Q000188:drug therapy / Q000453:epidemiology*; D012307:Risk Factors; D012737:Sex Factors; D016103:Spinal Fractures / Q000453:epidemiology*
chemical_list: D005938:Glucocorticoids