Effects of carbamazepine on spinal cord ischemia.
BACKGROUND
Prophylactic treatment with carbamazepine has been shown to reduce the cerebral damage and neurologic deficit in ischemic conditions. A randomized controlled study based on a rabbit model was designed to study the effect of carbamazepine on a spinal cord ischemic reperfusion injury.


METHODS
Thirty New Zealand rabbits were randomly assigned to 1 of the 2 groups (n = 15 per group): group I (control group) and group II (carbamazepine group). Spinal cord ischemia was induced by infrarenal aortic crossclamp for 25 minutes in both groups. Functional evaluation with the Tarlov score during a 2-day observation period and histopathologic assessment of the lumbar spinal cord were performed. Changes in spinal cord morphology were observed with hematoxylin-eosin staining and electron microscopy. Gray matter damage was assessed on the basis of the number of normal neurons in the ventral horn.


RESULTS
Diffuse destruction of gray matter with moderate to severe vacuolization and essentially no normal ganglion cells was observed in the spinal cord of rabbits in the control group, whereas specimens of rabbits assigned to the carbamazepine group showed ganglion cells with normal nuclei and cytoplasm (P < .0001). Neurologic impairment was significantly attenuated in the carbamazepine group compared with the Tarlov scores of the control group (P < .0001 at day 2).


CONCLUSIONS
Carbamazepine may protect the spinal cord from ischemic reperfusion injury that is associated with ameliorated neurologic and histopathologic results.
Sirlak
Mustafa
M
Department of Cardiovascular Surgery, Ankara University School of Medicine, Ankara, Turkey.
Eryilmaz
Sadik
S
Bahadir Inan
Mustafa
M
Sirin
Yusuf Sinan
YS
Besalti
Omer
O
Yazicioglu
Levent
L
Ozcinar
Evren
E
Erdemli
Esra
E
Tasoz
Refik
R
Elhan
Atilla Halil
AH
Kaya
Bulent
B
Ozyurda
Umit
U
D000818:Animals; D001707:Biopsy, Needle; D002220:Carbamazepine / Q000494:pharmacology*; D004195:Disease Models, Animal; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D011336:Probability; D011817:Rabbits; D011897:Random Allocation; D012016:Reference Values; D012680:Sensitivity and Specificity; D013116:Spinal Cord / Q000473:pathology / Q000648:ultrastructure; D013119:Spinal Cord Injuries / Q000517:prevention & control*; D020760:Spinal Cord Ischemia / Q000188:drug therapy* / Q000473:pathology*; D018709:Statistics, Nonparametric
D002220:Carbamazepine