title: Nortriterpenoids and lignans from Schisandra sphenanthera.
abstract: Nortriterpenoids, sphenadilactone C (1) and sphenasin A (2), together with four known lignans (3-6), were isolated from the leaves and stems of Schisandra sphenanthera. Their structures were elucidated by extensive analysis of 1D and 2D NMR spectroscopic data and compound 2 was further confirmed by single-crystal X-ray diffraction. Compound 1 features a partial enol moiety and an acetamide group in its structure. In addition, compounds 1, 3-6 showed weak anti-HIV-1 activity with EC(50) values in the range of 15.5-29.5 microg/mL.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PR China.
authors.forename: Wei-Lie
authors.initials: WL
authors.lastname: Xiao
authors.forename: Sheng-Xiong
authors.initials: SX
authors.lastname: Huang
authors.forename: Rui-Rui
authors.initials: RR
authors.lastname: Wang
authors.forename: Jia-Liang
authors.initials: JL
authors.lastname: Zhong
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Gao
authors.forename: Fei
authors.initials: F
authors.lastname: He
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Pu
authors.forename: Yang
authors.initials: Y
authors.lastname: Lu
authors.forename: Yong-Tang
authors.initials: YT
authors.lastname: Zheng
authors.forename: Qi-Tai
authors.initials: QT
authors.lastname: Zheng
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D002460:Cell Line; D034242:Cyclooctanes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004149:Dioxoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D011083:Polycyclic Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D032141:Schisandra / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D034242:Cyclooctanes; D004149:Dioxoles; D017705:Lignans; D010936:Plant Extracts; D011083:Polycyclic Compounds; D014315:Triterpenes; C534608:sphenadilactone C; C534609:sphenasin A; C082093:schisantherin D; C034557:schizandrer A; C011105:schizandrin; C082091:gomisin J