In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria.
The antianaerobic activity of tomopenem, a new longer-half-life parenteral carbapenem, was compared with other carbapenems. Tomopenem showed broad activity against 63 reference species. The activity of tomopenem against 293 clinical isolates was potent (MIC(90), 0.06 to 4 microg/ml) and comparable to those of meropenem and doripenem and more potent than that of panipenem.
Tanaka
Kaori
K
Division of Anaerobe Research, Life Science Research Center, Gifu University, Gifu, Japan. kktb@gifu-u.ac.jp
Mikamo
Hiroshige
H
Nakao
Kenichi
K
Ichiishi
Taku
T
Goto
Takatsugu
T
Yamagishi
Yuka
Y
Watanabe
Kunitomo
K
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D015780:Carbapenems / Q000494:pharmacology*; D000077726:Doripenem; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D013845:Thienamycins / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D015780:Carbapenems; D013845:Thienamycins; D000077726:Doripenem; D000077731:Meropenem; C039536:panipenem