[Peptidergic regulation of the pancreas function in the experimental model of rats with accelerated aging].
This study was devoted to the evaluation of morphofunctional alterations in the pancreas in the conditions of physiological and premature aging using the experimental model of irradiation-induced aging, and the possibility of peptidergic regulation of age-related alterations in the pancreas was also studied. Age-related alterations in the pancreas of old animals in the conditions of physiological aging were revealed in the form of dystrophic alterations of main cell populations, disordered microcirculatory vascular channels and reduced level of physiological regeneration of this organ. In the conditions of irradiation-induced premature aging the above mentioned manifestations of dystrophic alterations in the pancreas tissue were found to be more pronounced. Administration of tripeptide T-38 (Lys-Glu-Asp) to old irradiated animals activated the processes of post-irradiation reparative regeneration, thus restoring the disordered endocrine homeostasis in the pancreas.
Ryzhak
A P
AP
Kvetnoĭ
I M
IM
Emanuél'
V L
VL
D019588:Aging, Premature / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D000818:Animals; D004195:Disease Models, Animal; D007274:Injections, Intraperitoneal; D008297:Male; D008833:Microcirculation / Q000187:drug effects / Q000528:radiation effects; D055806:Microvessels / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D009842:Oligopeptides / Q000008:administration & dosage / Q000627:therapeutic use*; D010179:Pancreas / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects; D010187:Pancreatic Hormones / Q000378:metabolism*; D011833:Radiation Injuries, Experimental / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar
D009842:Oligopeptides; D010187:Pancreatic Hormones; C533570:lysyl-glutamyl-aspartic acid