title: Value of prenatal magnetic resonance imaging in the prediction of postnatal outcome in fetuses with diaphragmatic hernia.
abstract: OBJECTIVE
  To investigate the potential value of antenatally determined total fetal lung volume (TFLV) by magnetic resonance imaging (MRI) in the prediction of the postnatal survival in congenital diaphragmatic hernia (CDH).
  
  
  METHODS
  We examined fetuses with isolated CDH, in which MRI was used at 22-38 weeks of gestation to measure TFLV and assess intrathoracic herniation of abdominal viscera, that were liveborn after 30 weeks of gestation and had postnatal follow-up until death or discharge from hospital. Regression analysis was used to investigate the effect on survival of gestational age at diagnosis, observed to expected (o/e) TFLV, intrathoracic herniation of the liver, side of CDH, gestational age at MRI, institution, year and gestational age at delivery. In 76 fetuses measurements of o/e TFLV and the lung area to head circumference ratio (LHR) were performed within 2 weeks of each other; in these cases o/e TFLV and o/e LHR were compared for their prediction of postnatal survival.
  
  
  RESULTS
  In the 148 cases that fulfilled the entry criteria, multiple regression analysis demonstrated that significant predictors of survival were the presence or absence of intrathoracic herniation of the liver and o/e TFLV. The area under the receiver-operating characteristics curves for prediction of postnatal survival from o/e TFLV was 0.786 (standard error, 0.059; P < 0.001) and that from o/e LHR was 0.743 (standard error, 0.069; P = 0.001).
  
  
  CONCLUSIONS
  In the assessment of fetuses with CDH, MRI-based o/e TFLV is useful in the prediction of postnatal survival.
authors.affiliation: Radiology and Fetal Medicine Unit of King's College Hospital, London, UK. jackjani@hotmail.com
authors.forename: J
authors.initials: J
authors.lastname: Jani
authors.forename: M
authors.initials: M
authors.lastname: Cannie
authors.forename: P
authors.initials: P
authors.lastname: Sonigo
authors.forename: Y
authors.initials: Y
authors.lastname: Robert
authors.forename: O
authors.initials: O
authors.lastname: Moreno
authors.forename: A
authors.initials: A
authors.lastname: Benachi
authors.forename: P
authors.initials: P
authors.lastname: Vaast
authors.forename: E
authors.initials: E
authors.lastname: Gratacos
authors.forename: K H
authors.initials: KH
authors.lastname: Nicolaides
authors.forename: J
authors.initials: J
authors.lastname: Deprest
mesh_terms: D001699:Biometry; D002508:Cephalometry; D005260:Female; D005865:Gestational Age; D006548:Hernia, Diaphragmatic / Q000175:diagnosis* / Q000401:mortality; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D006976:Hypertension, Pulmonary / Q000151:congenital / Q000175:diagnosis* / Q000401:mortality; D007231:Infant, Newborn; D008176:Lung Volume Measurements; D008279:Magnetic Resonance Imaging; D008297:Male; D011237:Predictive Value of Tests; D011247:Pregnancy; D012372:ROC Curve; D012044:Regression Analysis; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal