Successful treatment of primary vaginal diffuse large B-cell lymphoma using chemotherapy.
OBJECTIVE
Non-Hodgkins lymphomas (NHL) rarely affect the vagina. As a result, a standard treatment has not been defined.


METHODS
A 34-year-old female virgin patient with a primary vaginal NHL stage IEA, diffuse large cell B lineage, showed an excellent response to cytotoxic chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisone) without surgery or radiotherapy. She had experienced no recurrence after 40 months.


CONCLUSIONS
In young patients who wish to preserve their fertility, chemotherapy alone may be the treatment of choice for primary diffuse large B-cell NHL of the lower female genital tract.
Akbayir
Ozgur
O
Gynecological Oncology Clinic, Istanbul Bakirkoy Woman and Children Hospital, Istanbul, Turkey.
Güngördük
Kemal
K
Gülkilik
Ahmet
A
Yavuz
Ekrem
E
Tekirdağ
Ali Ismet
AI
Odabaş
Engin
E
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001707:Biopsy, Needle; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D016403:Lymphoma, Large B-Cell, Diffuse / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology*; D011241:Prednisone / Q000008:administration & dosage; D016896:Treatment Outcome; D014463:Ultrasonography; D014625:Vaginal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology*; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone