Route of progesterone administration for luteal phase support may affect outcome of controlled ovarian hyperstimulation for IVF with ICSI using GnRH antagonist.
OBJECTIVE
This study evaluated the impact of route of progesterone administration as luteal phase support on the outcome of assisted conception cycles.


METHODS
Intramuscular progesterone in oil (IMP) at 100 mg daily was administered to 903 women following oocyte retrieval whereas vaginal progesterone gel (VMP) at 90 mg was administered twice daily to 1,110 women. Retrospective analysis was performed according to the type of GnRH analogue used. Implantation (IR), clinical pregnancy (CPR) and biochemical pregnancy rates (BPR) were main outcomes.


RESULTS
In GnRH agonist cycles, neither IR, CPR or BPR differed according to the route of progesterone. However, in GnRH antagonist cycles, IR and CPR were significantly lower in VMP group compared to IMP group. BPR also was significantly higher in VMP group compared to IMP group.


CONCLUSIONS
Our results suggest that route of progesterone administration for luteal phase support can be an important prognostic factor according to the type of GnRH analogue used for controlled ovarian hyperstimulation.
Bahceci
Mustafa
M
Bahceci Women Health Care Center, Azer Is Merkezi 44-17, Nisantasi, Abdi Ipekci Cad., 80200 Istanbul, Turkey. mbahceci@superonline.com
Ulug
Ulun
U
D000328:Adult; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D008183:Luteal Phase / Q000187:drug effects*; D016471:Ovarian Hyperstimulation Syndrome / Q000188:drug therapy*; D010062:Ovulation Induction; D011247:Pregnancy; D011374:Progesterone / Q000008:administration & dosage* / Q000627:therapeutic use; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic
D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone