A facile synthesis of alpha,alpha'-(EE)-bis(benzylidene)-cycloalkanones and their antitubercular evaluations.
An economical and facile synthesis of alpha,alpha'-(EE)-bis(benzylidene)-cycloalkanones was achieved by the reaction of cycloalkanones with different aromatic aldehydes using ethanolic KOH in good yields. Few of the selected compounds were reduced with NaBH(4) to the respective alpha,alpha'-(EE)-bis(benzylidene)-cycloalkanols. All these compounds and our earlier synthesized cyclohexyl phenyl methanols were evaluated for their antitubercular, antifungal and antibacterial activities. Several compounds displayed moderate antitubercular activity with MIC=12.5-1.56 microg/mL. However, none of the compounds displayed any significant antifungal activity.
Singh
Nimisha
N
Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, India.
Pandey
Jyoti
J
Yadav
Amit
A
Chaturvedi
Vinita
V
Bhatnagar
Shalini
S
Gaikwad
Anil N
AN
Sinha
Sudhir Kumar
SK
Kumar
Awaneet
A
Shukla
P K
PK
Tripathi
Rama P
RP
D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*
D000438:Alcohols; D000995:Antitubercular Agents