Palladium-catalyzed synthesis of 2-substituted benzothiazoles via a C-H functionalization/intramolecular C-S bond formation process.
Catalytic synthesis of 2-substituted benzothiazoles from thiobenzanilides was achieved in the presence of a palladium catalyst through C-H functionalization/C-S bond formation. This method features the use of a novel catalytic system consisting of 10 mol % of Pd(II), 50 mol % of Cu(I), and 2 equiv of Bu4NBr that produced variously substituted benzothiazoles in high yields with good functional group tolerance.
Inamoto
Kiyofumi
K
Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki, Sendai, Japan. inamoto@mail.pharm.tohoku.ac.jp
Hasegawa
Chisa
C
Hiroya
Kou
K
Doi
Takayuki
T
D052160:Benzothiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006859:Hydrogen / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D013455:Sulfur / Q000737:chemistry*
D052160:Benzothiazoles; D010165:Palladium; D013455:Sulfur; D002244:Carbon; D006859:Hydrogen; C005465:benzothiazole