Transplantation of epidermis of scar tissue on acellular dermal matrix.
This study enrolled 22 participants with hypertrophic scarring after burn who received treatment with co-transplantation of acellular dermal matrix and epidermis of either normal skin or scar tissue. Scar thickness was evaluated with high frequency ultrasonography and the distribution of keratinocyte stem cells was detected by immunostaining. The results showed p63-positive keratinocyte stem cells throughout the epidermis of scar tissue. However, if co-transplanted on acellular dermal matrix, this effectively inhibited scar formation and pruritus, providing an alternative method to treat hypertrophic scarring.
Wang
Guang-Qing
GQ
Department of Burn Surgery, Burns Institute, Changhai Hospital, Second Military Medical University, Shanghai, PR China. guangqing_wang@yahoo.com
Xia
Zhao-Fan
ZF
D000328:Adult; D002056:Burns / Q000150:complications* / Q000473:pathology; D017439:Cicatrix, Hypertrophic / Q000473:pathology / Q000601:surgery*; D004817:Epidermis / Q000637:transplantation*; D004954:Esthetics; D005260:Female; D006085:Graft Survival / Q000502:physiology; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism; D011537:Pruritus / Q000473:pathology; D016038:Skin Transplantation / Q000379:methods*; D017768:Skin, Artificial; D014945:Wound Healing / Q000502:physiology; D055815:Young Adult
C081876:CKAP4 protein, human; D008565:Membrane Proteins