Acute and late toxicity in prostate cancer patients treated by dose escalated intensity modulated radiation therapy and organ tracking.
BACKGROUND
To report acute and late toxicity in prostate cancer patients treated by dose escalated intensity-modulated radiation therapy (IMRT) and organ tracking.


METHODS
From 06/2004 to 12/2005 39 men were treated by 80 Gy IMRT along with organ tracking. Median age was 69 years, risk of recurrence was low 18%, intermediate 21% and high in 61% patients. Hormone therapy (HT) was received by 74% of patients. Toxicity was scored according to the CTC scale version 3.0. Median follow-up (FU) was 29 months.


RESULTS
Acute and maximal late grade 2 gastrointestinal (GI) toxicity was 3% and 8%, late grade 2 GI toxicity dropped to 0% at the end of FU. No acute or late grade 3 GI toxicity was observed. Grade 2 and 3 pre-treatment genitourinary (GU) morbidity (PGUM) was 20% and 5%. Acute and maximal late grade 2 GU toxicity was 56% and 28% and late grade 2 GU toxicity decreased to 15% of patients at the end of FU. Acute and maximal late grade 3 GU toxicity was 8% and 3%, respectively. Decreased late > or = grade 2 GU toxicity free survival was associated with higher age (P = .025), absence of HT (P = .016) and higher PGUM (P < .001).


CONCLUSIONS
GI toxicity rates after IMRT and organ tracking are excellent, GU toxicity rates are strongly related to PGUM.
Ghadjar
Pirus
P
Department of Radiation Oncology with Division of Medical Radiation Physics, University of Bern, Inselspital, Bern, Switzerland, Freiburgstrasse, 3010 Bern, Switzerland. pirus.ghadjar@insel.ch
Vock
Jacqueline
J
Vetterli
Daniel
D
Manser
Peter
P
Bigler
Roland
R
Tille
Jan
J
Madlung
Axel
A
Behrensmeier
Frank
F
Mini
Roberto
R
Aebersold
Daniel M
DM
D000368:Aged; D000369:Aged, 80 and over; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000209:etiology; D011879:Radiotherapy Dosage; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects*; D012008:Recurrence; D012306:Risk; D013997:Time Factors; D016896:Treatment Outcome