title: Synthesis of (S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile: a key intermediate for dipeptidyl peptidase IV inhibitors.
abstract: An alternative and practical synthesis of (S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile was achieved. Reaction of L-proline with chloroacetyl chloride was followed by conversion of the carboxylic acid moiety of the resulting N-acylated product into the carbonitrile via the corresponding amide intermediate. The synthesized pyrrolidine derivative was utilized to prepare DPP-IV inhibitor Vildagliptin.
authors.affiliation: New Drug Discovery, Matrix Laboratories Limited, Anrich Industrial Estate, Bollaram, Jinnaram Mandal, Medak Dist., Andhra Pradesh, India-502 325. sksingh_p2@rediffmail.com
authors.forename: Santosh Kumar
authors.initials: SK
authors.lastname: Singh
authors.forename: Narendra
authors.initials: N
authors.lastname: Manne
authors.forename: Manojit
authors.initials: M
authors.lastname: Pal