title: Corynebacterium-associated skin infections.
abstract: BACKGROUND
  Corynebacterium spp. are diphtheroid bacteria responsible for pitted keratolysis, a common plantar infection confined to the thick stratum corneum.
  
  
  OBJECTIVE
  To study a series of demographic features of patients suffering from pitted keratolysis, and to present a review of the Corynebacterium-associated infections, including pitted keratolysis, erythrasma, and trichobacteriosis.
  
  
  METHODS
  A 2-year, two-center, prospective survey assessed the demographics of pitted keratolysis, including age, gender, site of infection, symptoms, patients' complaints, the use of protective and/or occlusive shoes, seasonality of diagnosis, drug intake, associated skin signs (including dyshidrosis, erythrasma, and trichobacteriosis), recurrences, and previous diagnoses and treatments.
  
  
  RESULTS
  The mean age of the 53 patients with pitted keratolysis was 24.9 years (range, 10-57 years). The male to female ratio was 7.8:1. The soles of both feet were commonly involved (92.4%). Pressure-bearing areas were the usual sites of infection, ranging from restricted involvement of the toes (12/53, 22.6%) to spreading to the entire plantar surface (15/53, 28.3%). A total of 36 (68%) of the 53 patients complained of hyperhidrosis. An unpleasant smell and pain were noted by 35 (66%) and 25 (47%) of the 53 patients, respectively. Occlusive and protective shoes were worn in 51 (96.2%) and 31 (58.4%) of the 53 cases, respectively.
  
  
  CONCLUSIONS
  Pitted keratolysis commonly affects young male patients wearing protective shoes for professional reasons, inducing a moist and warm environment. Hyperhidrosis, an unpleasant smell, and pain are the main clinical complaints.
authors.affiliation: Department of Dermatopathology, University Hospital of Liège, Liège, Belgium.
authors.forename: Géraldine
authors.initials: G
authors.lastname: Blaise
authors.forename: Arjen F
authors.initials: AF
authors.lastname: Nikkels
authors.forename: Trihn
authors.initials: T
authors.lastname: Hermanns-Lê
authors.forename: Nazli
authors.initials: N
authors.lastname: Nikkels-Tassoudji
authors.forename: Gérald E
authors.initials: GE
authors.lastname: Piérard
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001707:Biopsy, Needle; D002648:Child; D003352:Corynebacterium / Q000302:isolation & purification*; D003354:Corynebacterium Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D017678:Sex Distribution; D017192:Skin Diseases, Bacterial / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents