Atypical furunculosis vaccines for Atlantic cod (Gadus morhua); vaccine efficacy and antibody responses.
Atypical furunculosis caused by atypical Aeromonas salmonicida, is an emerging problem in farming of Atlantic cod (Gadus morhua) in Norway, and vaccines are needed. Atypical A. salmonicida comprises a heterogeneous group of bacteria differing in surface antigens such as the A-layer protein and lipopolysaccharides (LPS). Except for one of the experimental oil-adjuvanted whole cell vaccines based on various isolates they all resulted in moderate protection. No clear correlation between vaccine efficacies and the A-protein group or LPS type of the vaccine isolates was revealed, while a correlation between efficacy and the presence of cross-reacting LPS-specific antibodies is indicated.
Lund
Vera
V
Nofima Marine, N-9291 Tromsø, Norway. vera.lund@nofima.no
Arnesen
Jan Arne
JA
Mikkelsen
Helene
H
Gravningen
Kjersti
K
Brown
Laura
L
Schrøder
Merete B
MB
D000276:Adjuvants, Immunologic; D048409:Aeromonas salmonicida / Q000235:genetics / Q000276:immunology*; D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis / Q000096:biosynthesis / Q000276:immunology; D001428:Bacterial Vaccines / Q000235:genetics / Q000276:immunology* / Q000627:therapeutic use*; D015153:Blotting, Western; D002626:Chemistry, Pharmaceutical; D004797:Enzyme-Linked Immunosorbent Assay; D005393:Fish Diseases / Q000276:immunology* / Q000382:microbiology / Q000517:prevention & control*; D005667:Furunculosis / Q000276:immunology* / Q000517:prevention & control / Q000662:veterinary*; D048389:Gadus morhua / Q000276:immunology*; D008070:Lipopolysaccharides / Q000276:immunology; D014774:Virulence
D000276:Adjuvants, Immunologic; D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D008070:Lipopolysaccharides