Intravenous immunoglobulin therapy for severe arthritis associated with human parvovirus B19 infection.
Symptoms caused by acute human parvovirus B19 (HPV-B19) infection can vary considerably, from asymptomatic to severely symptomatic. A 39-year-old Japanese woman complained of sudden, severe arthralgia with edematous limbs coincident with an outbreak of HPV-B19 infection at the elementary school attended by her daughter. A diagnosis of acute HPV-B19 infection was made by the detection of serum antibody to HPV-B19 IgM and HPV-B19 DNA. Magnetic resonance imaging revealed bilateral synovitis of the cubital joints. The patient was immunocompetent and suffered from severe arthralgia associated with persistent HPV-B19 viremia for more than 4 months after the diagnosis of acute HPV-B19 infection. The administration of high-dose intravenous immunoglobulin resulted in remission, with little change in the serum HPV-B19 DNA level. Even in our immunocompetent patient, severe and prolonged arthritis was found to be associated with persistent viremia.
Ogawa
Eiichi
E
Department of General Medicine, Kyushu University Hospital, 3-1-1 Maidashi, Fukuoka, 812-8582, Japan.
Otaguro
Shigeru
S
Murata
Masayuki
M
Kainuma
Mosaburo
M
Sawayama
Yasunori
Y
Furusyo
Norihiro
N
Hayashi
Jun
J
D000328:Adult; D001170:Arthritis, Infectious / Q000628:therapy* / Q000821:virology; D001842:Bone and Bones / Q000000981:diagnostic imaging; D004550:Elbow; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D010322:Parvoviridae Infections / Q000175:diagnosis / Q000628:therapy* / Q000821:virology; D016732:Parvovirus B19, Human / Q000235:genetics / Q000302:isolation & purification*; D011877:Radionuclide Imaging
D016756:Immunoglobulins, Intravenous