Optical density of bone repair after implantation of homogenous demineralized dentin matrix in diabetic rabbits.
This research evaluated the bone repair process after implantation of homogenous demineralized dentin matrix (HDDM) in surgical defects in the parietal bone of rabbits with alloxan-induced diabetes, using a polytetrafluorethylene (PTFe) barrier for guided bone regeneration. Thirty-six rabbits were used and divided into four groups: control (C, n = 12), diabetic (D, n = 12, left parietal bone), diabetic with PTFe (D-PTFe, same 12 rabbits, right parietal bone), and diabetic with PTFe associated to HDDM (D-PTFe+HDDM, n = 12). Bone defects were created in the parietal bone of the rabbits and the experimental treatments were performed, where applicable. The rabbits were sacrificed after 15, 30, 60 and 90 days. The bone defects were examined radiographically and by optical density (ANOVA and Tukey test, p < .05). The radiographic findings showed that the D-PTFe+HDDM group presented greater radiopacity and better trabecular bone arrangement when compared to that of the C, D and D-PTFe groups. The statistical analysis showed significant differences in the optical density of the newly formed bone among the studied groups. It was possible to conclude that HDDM was biocompatible in diabetic rabbits.
Gomes
Mônica Fernandes
MF
School of Dentistry of São José dos Campos, São Paulo State University, São José dos Campos, SP, Brazil. mfgomes@fosjc.unesp.br
Destro
Maria Fernanda de Souza Setúbal
MF
Banzi
Efani Caroline de Freitas
EC
Vieira
Evanice Menezes Marçal
EM
Morosolli
Aline Rose Cantarelli
AR
Goulart
Maria das Graças Vilela
Md
D000496:Alloxan; D000818:Animals; D001672:Biocompatible Materials / Q000378:metabolism / Q000627:therapeutic use*; D015519:Bone Density / Q000502:physiology*; D001861:Bone Regeneration / Q000187:drug effects / Q000502:physiology*; D003804:Dentin / Q000187:drug effects / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D004195:Disease Models, Animal; D048091:Guided Tissue Regeneration / Q000379:methods*; D010012:Osteogenesis / Q000502:physiology; D010294:Parietal Bone / Q000502:physiology / Q000601:surgery; D011138:Polytetrafluoroethylene / Q000627:therapeutic use; D019736:Prostheses and Implants; D011817:Rabbits
D001672:Biocompatible Materials; C093073:Demineralized Dentin Matrix; D000496:Alloxan; D011138:Polytetrafluoroethylene