A role for Th17 cells in the immunopathogenesis of atopic dermatitis?
Atopic dermatitis (AD) is a common inflammatory skin disease. Both epidermal barrier dysfunction and immunodysregulation are suggested to influence the pathogenesis of AD. AD has been considered a paradigmatic T helper cell (Th) 2-mediated disease, with a switch to a Th1 cell environment during the chronic phase of the disease. Previously unreported findings now suggest a possible role for Th17 cells as well.
Cesare
Antonella Di
AD
St. John's Institute of Dermatology, King's College London School of Medicine and NIHR Biomedical Research Centre, London, United Kingdom; Department of Dermatology, University of L'Aquila L'Aquila, Italy.
Meglio
Paola Di
PD
St. John's Institute of Dermatology, King's College London School of Medicine and NIHR Biomedical Research Centre, London, United Kingdom.
Nestle
Frank O
FO
St. John's Institute of Dermatology, King's College London School of Medicine and NIHR Biomedical Research Centre, London, United Kingdom. Electronic address: frank.nestle@kcl.ac.uk.
D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D003876:Dermatitis, Atopic / Q000209:etiology* / Q000276:immunology*; D018450:Disease Progression; D006801:Humans; D020381:Interleukin-17 / Q000378:metabolism*; D012720:Severity of Illness Index; D006377:T-Lymphocytes, Helper-Inducer / Q000378:metabolism*; D018417:Th1 Cells / Q000378:metabolism; D018418:Th2 Cells / Q000378:metabolism
D020381:Interleukin-17