Laboratory testing for fibrinogen abnormalities.
Fibrinogen is essential for the formation of a fibrin clot. Acquired and congenital disorders of fibrinogen may result in decreased concentration or altered function of fibrinogen, often leading to an increased risk of bleeding. Routine coagulation testing and specialized laboratory investigations can guide diagnosis in patients suspected of having a fibrinogen abnormality. This article summarizes the types of laboratory assays that are used to assess fibrinogen disorders, and key abnormalities found in different types of fibrinogen disorders.
Verhovsek
Madeleine
M
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Moffat
Karen A
KA
Hayward
Catherine P M
CP
D000347:Afibrinogenemia / Q000097:blood* / Q000175:diagnosis; D001780:Blood Coagulation Tests; D015241:Fibrinogens, Abnormal / Q000302:isolation & purification*; D006801:Humans
D015241:Fibrinogens, Abnormal