Gammadelta T-cells: potential regulators of the post-burn inflammatory response.
Severe burn induces an immunopathological response that contributes to the development of a systemic inflammatory response (SIRS) and subsequent multiple organ failure. While, multiple immune cells type (T-cells, macrophages, neutrophils) are involved in this response, recent evidence suggests that a unique T-cell subset, gammadelta T-cells are central in the response to injury. While gammadelta T-cells represent only a small percentage of the total T-cell population, they display specific functional characteristics that uniquely position them in the immune/inflammatory axis to influence a number of important aspects of the body's response to burn. This review will focus on the potential regulator role of gammadelta T-cells in immunopathological response following burn and thereby their potential as therapeutic targets for affecting inflammation and healing.
Schwacha
Martin G
MG
Department of Surgery, Division of Trauma and Emergency Surgery, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, United States.
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002056:Burns / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007111:Immunity, Cellular; D007167:Immunotherapy / Q000379:methods; D007249:Inflammation / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D012867:Skin / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000502:physiology* / Q000637:transplantation; D013601:T-Lymphocytes / Q000276:immunology; D014945:Wound Healing / Q000276:immunology*
D015415:Biomarkers