title: The effects of preanesthetic, single-dose dexmedetomidine on induction, hemodynamic, and cardiovascular parameters.
abstract: OBJECTIVE
  To investigate the hemodynamic, cardiovascular, and recovery effects of dexmedetomidine used as a single preanesthetic dose.
  
  
  METHODS
  Randomized, prospective, double-blind study.
  
  
  METHODS
  University Hospital of Kirikkale, Kirikkale, Turkey.
  
  
  METHODS
  40 ASA physical status I and II patients, aged 20 to 60 years, who were scheduled for elective cholecystectomy.
  
  
  METHODS
  Patients were randomly divided into two groups to receive 0.5 microg kg(-1) dexmedetomidine (group D, n = 20) or saline solution (group C, n = 20). Anesthesia was induced with thiopental sodium and vecuronium, and anesthesia was maintained with 4% to 6% desflurane.
  
  
  METHODS
  Mean arterial pressure (MAP), heart rate (HR), ejection fraction (EF), end-diastolic index (EDI), cardiac index (CI), and stroke volume index (SVI) were recorded at 10-minute intervals. The times for patients to "open eyes on verbal command" and postoperative Aldrete recovery scores were also recorded.
  
  
  RESULTS
  In group C, an increase in HR and MAP occurred after endotracheal intubation. In group D, HR significantly decreased after dexmedetomidine was given. The EDI, CI, SVI, and EF values were similar in groups D and C. The modified Aldrete recovery scores of patients in the recovery room were similar in groups C and D at the 15th minute.
  
  
  CONCLUSIONS
  A single dose of dexmedetomidine given before induction of anesthesia decreased thiopental requirements without serious hemodynamic effects or any effect on recovery time.
authors.affiliation: Department of Anesthesiology and Reanimation, Ministry of Health, Ankara Training and Education Hospital, Ankara, Turkey. hulya_basar@yahoo.com
authors.forename: Hülya
authors.initials: H
authors.lastname: Basar
authors.forename: Serpil
authors.initials: S
authors.lastname: Akpinar
authors.forename: Nur
authors.initials: N
authors.lastname: Doganci
authors.forename: Unase
authors.initials: U
authors.lastname: Buyukkocak
authors.forename: Cetin
authors.initials: C
authors.lastname: Kaymak
authors.forename: Ozgur
authors.initials: O
authors.lastname: Sert
authors.forename: Alpaslan
authors.initials: A
authors.lastname: Apan
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage* / Q000494:pharmacology; D000328:Adult; D000762:Anesthesia Recovery Period; D000769:Anesthesia, Inhalation / Q000379:methods*; D001794:Blood Pressure / Q000187:drug effects*; D002763:Cholecystectomy; D020927:Dexmedetomidine / Q000008:administration & dosage* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D017558:Elective Surgical Procedures; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011229:Preanesthetic Medication / Q000379:methods*; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D000316:Adrenergic alpha-Agonists; D020927:Dexmedetomidine