Small RNAs establish gene expression thresholds.
The central role of small RNAs in regulating bacterial gene expression has been elucidated in the past years. Typically, small RNAs act via specific basepairing with target mRNAs, leading to modulation of translation initiation and mRNA stability. Quantitative studies suggest that small RNA regulation is characterized by unique features, which allow it to complement regulation at the transcriptional level. In particular, small RNAs are shown to establish a threshold for the expression of their target, providing safety mechanism against random fluctuations and transient signals. The threshold level is set by the transcription rate of the small RNA and can thus be modulated dynamically to reflect changing environmental conditions.
Levine
Erel
E
Center for Theoretical Biological Physics and Department of Physics, University of California at San Diego, La Jolla, CA 92093, United States. elevine@ucsd.edu
Hwa
Terence
T
D018407:Bacterial Physiological Phenomena; D015964:Gene Expression Regulation, Bacterial; D014176:Protein Biosynthesis; D020871:RNA Stability; D022661:RNA, Untranslated / Q000378:metabolism*; D014158:Transcription, Genetic
D022661:RNA, Untranslated