The role of glycogen synthase kinase 3 in the early stages of Alzheimers' disease.
There are two different types of Alzheimers' disease, familiar Alzheimers' disease (FAD) and Sporadic Alzheimers' disease (SAD), and the origin of the disease could be different in both familial and sporadic cases. In terms of FAD, mutations in three different genes are likely to promote the onset of the disease whereas for SAD, different risk factors might be involved. Nevertheless, downstream of the initial causes of the disease some common factors may be involved. In this review, rather than the differences, we have focused on some of the common features shared by Alzheimers' patients, irrespective of the origin of their disorder. Among these common features, at the molecular level, the activation of the protein kinase GSK3 may be relevant.
Hernández
Félix
F
Centro de Biologi a Molecular "Severo Ochoa" (CSIC-UAM), Campus de Cantoblanco 28049 Madrid, Spain.
Avila
Jesús
J
D000375:Aging / Q000378:metabolism; D000544:Alzheimer Disease / Q000201:enzymology*; D000682:Amyloid / Q000378:metabolism; D004789:Enzyme Activation; D038362:Glycogen Synthase Kinase 3 / Q000378:metabolism*; D006801:Humans; D018384:Oxidative Stress; D012307:Risk Factors; D016875:tau Proteins / Q000378:metabolism
D000682:Amyloid; D016875:tau Proteins; D038362:Glycogen Synthase Kinase 3