Cytokine regulation of tight junctions.
Epithelial and endothelial tight junctions act as a rate-limiting barrier between an organism and its environment. Continuing studies have highlighted the regulation of the tight junction barrier by cytokines. Elucidation of this interplay is vital for both the understanding of physiological tight junction regulation and the etiology of pathological conditions. This review will focus on recent advances in our understanding of the molecular mechanisms of tight junctions modulation by cytokines.
Capaldo
Christopher T
CT
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA.
Nusrat
Asma
A
D000199:Actins / Q000378:metabolism; D000818:Animals; D062445:Claudin-1; D016207:Cytokines / Q000378:metabolism*; D004705:Endocytosis / Q000502:physiology; D004847:Epithelial Cells / Q000378:metabolism; D006801:Humans; D007371:Interferon-gamma / Q000502:physiology*; D007378:Interleukins / Q000502:physiology; D008565:Membrane Proteins / Q000378:metabolism; D062793:Occludin; D019108:Tight Junctions / Q000502:physiology*; D016211:Transforming Growth Factor alpha / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology*
D000199:Actins; C568108:CLDN1 protein, human; D062445:Claudin-1; D016207:Cytokines; D007378:Interleukins; D008565:Membrane Proteins; C568985:OCLN protein, human; D062793:Occludin; D016211:Transforming Growth Factor alpha; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma