title: New diterpenoids and the bioactivity of Erythrophleum fordii.
abstract: A phytochemical investigation of the leaves of Erythrophleum fordii Oliv. has led to the isolation of three new cassaine-type diterpenoids, erythrofordin A (1), erythrofordin B (2) and erythrofordin C (3), as well as a norcassaine diterpenoid with a novel skeleton, norerythrofordin A (4), and 27 known compounds (5-31). The structures of 1-4 were elucidated on the basis of spectroscopic analysis. Selected compounds from this plant were examined for anti-inflammatory activity. Taraxerol (16) displayed potent NO-reducing activity in microglial cells, and gallic acid (27) exhibited excellent DPPH radical-scavenging effects.
authors.affiliation: Department of Chemistry, National Cheng Kung University, No. 1 University Road, Tainan 701, Taiwan.
authors.forename: Chuan-Chung
authors.initials: CC
authors.lastname: Tsao
authors.forename: Yuh-Chiang
authors.initials: YC
authors.lastname: Shen
authors.forename: Chung-Ren
authors.initials: CR
authors.lastname: Su
authors.forename: Chia-Ying
authors.initials: CY
authors.lastname: Li
authors.forename: Meei-Jen
authors.initials: MJ
authors.lastname: Liou
authors.forename: Nguyen-Xuan
authors.initials: NX
authors.lastname: Dung
authors.forename: Tian-Shung
authors.initials: TS
authors.lastname: Wu
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D002478:Cells, Cultured; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007887:Fabaceae / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000378:metabolism; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D016166:Free Radical Scavengers; D010936:Plant Extracts; D009569:Nitric Oxide