title: Evaluation of quality of life after simultaneous pancreas and kidney transplantation from living donors using short form 36.
abstract: We performed the first case of simultaneous pancreas and kidney transplantation from a living donor (LDSPK) in 2004. We examined the quality of life (QOL) of performed 6 recipients and 5 donors among 8 LDSPK from 2004 to 2007 at our institution using Short Form 36. All recipients achieved insulin and hemodialysis independence after LDSPK with positive serum C-peptide levels. Before LDSPK, all scores of the 8 specific domains of the recipients were low (28.2 +/- 10.6), indicating extremely poor QOL. Both the Physical and the Mental Component Summary Scores (PCS/MCS) quickly increased after LDSPK. PCS at 6, 12, and 24 months after LDSPK were significantly higher than the pretransplantation level. MCS were also significantly higher than the pretransplantation level. LDSPK showed prominent QOL improvement for the recipient. Complications were not observed in any donor. Although PCS decreased at 6 months after the operation, it recovered at 12 and at 24 months after the operation. MCS was maintained at more than 50 from 6 to 24 months after the operation. QOL was well preserved in the LDSPK donors despite the major surgery. In conclusion, LDSPK was confirmed to be a potent tool for treatment of type 1 diabetes mellitus patients with end-stage renal disease (ESRD) by complete normalization of glucose metabolism and renal function. In addition to these medical advantages, both their physical and mental QOL were improved by LDSPK.
authors.affiliation: Clinical Research Center, Chiba-East National Hospital, National Hospital Organization, Chiba, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Kenmochi
authors.forename: M
authors.initials: M
authors.lastname: Maruyama
authors.forename: K
authors.initials: K
authors.lastname: Saigo
authors.forename: N
authors.initials: N
authors.lastname: Akutsu
authors.forename: C
authors.initials: C
authors.lastname: Iwashita
authors.forename: K
authors.initials: K
authors.lastname: Otsuki
authors.forename: M
authors.initials: M
authors.lastname: Miyazaki
mesh_terms: D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D003928:Diabetic Nephropathies / Q000601:surgery*; D005220:Fathers; D005260:Female; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation / Q000502:physiology* / Q000523:psychology; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009035:Mothers; D009392:Nephrectomy / Q000379:methods; D016035:Pancreas Transplantation / Q000502:physiology* / Q000523:psychology; D010180:Pancreatectomy / Q000379:methods; D011788:Quality of Life; D006435:Renal Dialysis; D011795:Surveys and Questionnaires
chemical_list: D007328:Insulin