title: PharmGKB: understanding the effects of individual genetic variants.
abstract: The Pharmacogenetics and Pharmacogenomics Knowledge Base (PharmGKB: http://www.pharmgkb.org) is devoted to disseminating primary data and knowledge in pharmacogenetics and pharmacogenomics. We are annotating the genes that are most important for drug response and present this information in the form of Very Important Pharmacogene (VIP) summaries, pathway diagrams, and curated literature. The PharmGKB currently contains information on over 500 drugs, 500 diseases, and 700 genes with genotyped variants. New features focus on capturing the phenotypic consequences of individual genetic variants. These features link variant genotypes to phenotypes, increase the breadth of pharmacogenomics literature curated, and visualize single-nucleotide polymorphisms on a gene's three-dimensional protein structure.
authors.affiliation: Department of Genetics, Stanford University, Stanford, California 94305-5120, USA.
authors.forename: Katrin
authors.initials: K
authors.lastname: Sangkuhl
authors.forename: Dorit S
authors.initials: DS
authors.lastname: Berlin
authors.forename: Russ B
authors.initials: RB
authors.lastname: Altman
authors.forename: Teri E
authors.initials: TE
authors.lastname: Klein
mesh_terms: D014644:Genetic Variation / Q000187:drug effects / Q000235:genetics*; D006801:Humans; D020407:Internet / Q000592:standards; D004364:Pharmaceutical Preparations / Q000737:chemistry* / Q000378:metabolism*; D010597:Pharmacogenetics / Q000379:methods* / Q000592:standards / Q000639:trends; D017433:Protein Structure, Secondary / Q000187:drug effects; D015398:Signal Transduction / Q000235:genetics
chemical_list: D004364:Pharmaceutical Preparations