Using notches to track mammary epithelial cell homeostasis.
Notch signals mediate a wide range of activities in development and cancer. A report in this issue of Cell Stem Cell (Bouras et al., 2008) demonstrates that Notch serves as a switch that controls cell fate and tissue homeostasis in mammary epithelium.
Robinson
Gertraud W
GW
Laboratory of Genetics and Physiology, NIDDK, NIH, Bethesda, MD 20892, USA. gertraur@bdg10.niddk.nih.gov
D000818:Animals; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000235:genetics / Q000378:metabolism*; D002454:Cell Differentiation; D019070:Cell Lineage; D049109:Cell Proliferation; D004847:Epithelial Cells / Q000166:cytology* / Q000378:metabolism; D005260:Female; D006706:Homeostasis; D051819:Immunoglobulin J Recombination Signal Sequence-Binding Protein; D008321:Mammary Glands, Animal / Q000166:cytology* / Q000378:metabolism; D051379:Mice; D011247:Pregnancy; D051881:Receptor, Notch1 / Q000378:metabolism*; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology / Q000502:physiology; D014161:Transduction, Genetic
D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D051819:Immunoglobulin J Recombination Signal Sequence-Binding Protein; C497762:Notch1 protein, mouse; C497571:Rbpj protein, mouse; D051881:Receptor, Notch1