Cellular and behavioral effects of stilbene resveratrol analogues: implications for reducing the deleterious effects of aging.
Research suggests that polyphenolic compounds contained in fruits and vegetables that are rich in color may have potent antioxidant and anti-inflammatory activities. The present studies determined if stilbene (e.g., resveratrol) compounds would be efficacious in reversing the deleterious effects of aging in 19 month old Fischer 344 rats. Experiment I utilized resveratrol and six resveratrol analogues and examined their efficacies in preventing dopamine-induced decrements in calcium clearance following oxotremorine-induced depolarization in COS-7 cells transfected with M1 muscarinic receptors (MAChR) that we have shown previously to be sensitive to oxidative stressors. Experiment II utilized the most efficacious analogue (pterostilbene) from experiment I and fed aged rats a diet with a low (0.004%) or a high (0.016%) concentration of pterostilbene. Results indicated that pterostilbene was effective in reversing cognitive behavioral deficits, as well as dopamine release, and working memory was correlated with pterostilbene levels in the hippocampus.
Joseph
James A
JA
US Department of Agriculture, Agricultural Research Service, Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA. jim.joseph@ars.usda.gov
Fisher
Derek R
DR
Cheng
Vivian
V
Rimando
Agnes M
AM
Shukitt-Hale
Barbara
B
D000375:Aging / Q000187:drug effects*; D000818:Animals; D019556:COS Cells; D002118:Calcium / Q000378:metabolism; D002522:Chlorocebus aethiops; D003072:Cognition Disorders / Q000188:drug therapy; D004032:Diet; D004298:Dopamine / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D011916:Rats, Inbred F344; D043643:Receptor, Muscarinic M1 / Q000235:genetics / Q000502:physiology; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage / Q000494:pharmacology*; D014162:Transfection
D043643:Receptor, Muscarinic M1; D013267:Stilbenes; C107773:pterostilbene; D000077185:Resveratrol; D002118:Calcium; D004298:Dopamine