title: Chest radiographic and CT manifestations of chronic granulomatous disease in adults.
abstract: OBJECTIVE
  The purpose of this study was to describe the thoracic radiologic findings of chronic granulomatous disease in adults.
  
  
  METHODS
  We retrospectively analyzed the chest radiographic and CT findings in four adults with chronic granulomatous disease during five episodes of lower respiratory tract infection.
  
  
  RESULTS
  Chest radiographic findings included areas of consolidation (60%), diffuse reticulonodular opacities (40%), pleural effusion (20%), and pulmonary artery enlargement (20%). CT findings included areas of consolidation (60%), pulmonary nodules in a random distribution (60%), centrilobular nodules (60%), tree-in-bud opacities (40%), areas of scarring and traction bronchiectasis (100%), emphysematous changes (75%), areas of decreased attenuation and vascularity associated with air trapping on expiratory CT (50%), mediastinal and/or hilar lymphadenopathy (60%), pulmonary artery enlargement (50%), and pleural effusion (20%). Areas of consolidation and nodules were the most prominent findings and at histologic examination were found to be associated with infection or granulomatous inflammation.
  
  
  CONCLUSIONS
  The pulmonary radiologic findings of chronic granulomatous disease include consolidation, nodules, areas of scarring, traction bronchiectasis, emphysema, air trapping, mediastinal and hilar lymphadenopathy, pulmonary artery enlargement, and pleural effusion.
authors.affiliation: Department of Radiology, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada. migbarco@gmail.com
authors.forename: Myrna C B
authors.initials: MC
authors.lastname: Godoy
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Vos
authors.forename: Peter L
authors.initials: PL
authors.lastname: Cooperberg
authors.forename: Carmen P
authors.initials: CP
authors.lastname: Lydell
authors.forename: Peter
authors.initials: P
authors.lastname: Phillips
authors.forename: Nestor L
authors.initials: NL
authors.lastname: Müller
mesh_terms: D000328:Adult; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D018410:Pneumonia, Bacterial / Q000000981:diagnostic imaging*; D013902:Radiography, Thoracic / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*