title: Skin lesions in hospitalized cases of dengue Fever.
abstract: OBJECTIVE
  To determine the frequency and types of skin lesions in cases of dengue fever in patients admitted in three hospitals of Karachi.
  
  
  METHODS
  Case series.
  
  
  METHODS
  Three tertiary care hospitals of Karachi, from November 2006 to February 2007.
  
  
  METHODS
  One hundred patients of dengue fever with positive anti-dengue Immunoglobulin M (IgM) serology were included in the study. The admitted patients in PNS Shifa Hospital, Jinnah Postgraduate Medical Centre (JPMC) and Civil Hospital, Karachi were selected for the study. Presenting features were noted. The patients were physically examined for the presence of skin and mucosal lesions and findings were recorded. Total and Differential Leukocyte Count (TLC and DLC), platelet count and Liver Function Tests (LFTs) were done in all the patients.
  
  
  RESULTS
  All the patients had low leukocyte and low platelet counts. The common presenting symptoms were high-grade fever with or without rigors, headache, body aches, backache, vomiting, sore throat with cough and generalized weakness (seen in 86% patients). The uncommon presenting features were diarrhea, abdominal pain, bleeding from gums and nosebleeds (seen in 14% patients). Sixty-eight (68%) patients had skin lesions. The most common skin presentation was generalized macular blanchable erythema involving trunk and limbs, seen in 44 (65%) cases. Discrete petechial lesions were seen on various body areas in 24 (35%) cases. Palmer erythema was seen in 20 (30%) patients. Generalized itching was seen in 16 (23%) cases. Isolated itching of palms and soles was seen in 20 (30%) cases. Twenty-eight (28%) patients had deranged LFTs. Out of those, 4 patients had raised serum bilirubin level whereas rest of the 24 had raised ALT.
  
  
  CONCLUSIONS
  Dengue fever commonly presents with specific skin lesions. The skin lesions can be a clue to the diagnosis in difficult cases.
authors.affiliation: Department of Dermatology, PNS Shifa, Karachi. dr_khawer_saleem@yahoo.com
authors.forename: Khawer
authors.initials: K
authors.lastname: Saleem
authors.forename: Irfan
authors.initials: I
authors.lastname: Shaikh
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003715:Dengue / Q000150:complications* / Q000473:pathology* / Q000628:therapy; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D010154:Pakistan; D017193:Skin Diseases, Viral / Q000453:epidemiology* / Q000473:pathology / Q000628:therapy; D055815:Young Adult