title: [Lesser known aspects of gastroesophageal reflux disease: non-acid reflux and functional pyrosis].
abstract: Gastroesophageal reflux disease (GERD) is defined as a pathologic condition that develops when reflux of stomach contents produce annoying symptoms and/or complications. According to whether esophagitis is present, GERD is classified as being erosive and non-erosive. Functional pyrosis is defined by the presence of retrosternal burning for at least 6 months in the absence of structural or metabolic alterations, GERD, or motor disorders that could cause the symptoms. Currently, functional pyrosis does not include patients with an acid-sensitive esophagus or those who improve with antisecretory drugs, which differentiates this entity from non-erosive GERD. GERD has usually been identified with acid reflux. However, the availability of new diagnostic methods such as Bilitec and, especially, impedance monitoring has revealed that acid, weakly acidic and gas reflux is able to produce distressing symptoms and complications in some patients.
authors.affiliation: Servicio de Medicina Digestiva, Hospital Universitari La Fe, Valencia, CIBERehd, Instituto de Salud Carlos III, Madrid, España.
authors.forename: Vicente
authors.initials: V
authors.lastname: Garrigues
authors.forename: Julio
authors.initials: J
authors.lastname: Ponce
mesh_terms: D000465:Algorithms; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D006356:Heartburn / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006801:Humans