Synthesis of new triazole-based trifluoromethyl scaffolds.
Trifluoromethyl propargylamines react with various azide derivatives to afford 1,4-disubstituted 1,2,3-triazoles through a Huisgen 1,3-dipolar cycloaddition. The reaction is catalyzed by a Cu(I) species in acetonitrile, and the corresponding products are obtained in good yields. This process thus offers an entry to new trifluoromethyl peptidomimetics as interesting scaffolds.
Martinelli
Michela
M
Laboratoire BioCIS-CNRS, Faculté de Pharmacie, Univ. Paris-Sud, rue J. B. Clément, F-92296 Châtenay-Malabry, France. michela.martinelli1@virgilio.it
Milcent
Thierry
T
Ongeri
Sandrine
S
Crousse
Benoit
B