Transfusion medicine in a developing country - alloantibodies to red blood cells in multi-transfused patients in Saudi Arabia.
BACKGROUND
Multiple transfusions are frequently complicated by alloimmunization. This retrospective study aims to determine whether alloimmunization could be accounted for by racial differences between donors and recipients.


METHODS
The development of alloantibodies were determined in 68 multi-transfused patients (thalassaemia, n=38) and (sickle cell anemia, n=30).


RESULTS
The overall frequency of alloantibody formation in our patients is 22.06%. Thirteen patients received blood from the same ethnic group (Arab) and none developed antibodies, while of 47 patients who received multi-ethnic blood, 10 developed alloantibodies.


CONCLUSIONS
Alloantibodies formation can be reduced by limiting the transfusion of RBC, collected from donors of the same ethnic origin.
Gader
Abdel Galil M Abdel
AG
The Blood Bank, King Khalid University Hospital, Riyadh 11461, Saudi Arabia. amagader@hotmail.com
Al Ghumlas
Abeer K
AK
Al-Momen
Abdel Kareem M
AK
D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood / Q000628:therapy*; D001803:Blood Transfusion; D002648:Child; D003906:Developing Countries; D005260:Female; D006801:Humans; D007518:Isoantibodies / Q000097:blood*; D008297:Male; D012529:Saudi Arabia; D013789:Thalassemia / Q000097:blood / Q000628:therapy*
D007518:Isoantibodies