title: GOBASE: an organelle genome database.
abstract: The organelle genome database GOBASE, now in its 21st release (June 2008), contains all published mitochondrion-encoded sequences (approximately 913,000) and chloroplast-encoded sequences (approximately 250,000) from a wide range of eukaryotic taxa. For all sequences, information on related genes, exons, introns, gene products and taxonomy is available, as well as selected genome maps and RNA secondary structures. Recent major enhancements to database functionality include: (i) addition of an interface for RNA editing data, with substitutions, insertions and deletions displayed using multiple alignments; (ii) addition of medically relevant information, such as haplotypes, SNPs and associated disease states, to human mitochondrial sequence data; (iii) addition of fully reannotated genome sequences for Escherichia coli and Nostoc sp., for reference and comparison; and (iv) a number of interface enhancements, such as the availability of both genomic and gene-coding sequence downloads, and a more sophisticated literature reference search functionality with links to PubMed where available. Future projects include the transfer of GOBASE features to NCBI/GenBank, allowing long-term preservation of accumulated expert information. The GOBASE database can be found at http://gobase.bcm.umontreal.ca/. Queries about custom and large-scale data retrievals should be addressed to gobase@bch.umontreal.ca.
authors.affiliation: Robert-Cedergren Center for Bioinformatics and Genomics, Département de Biochimie, Pavillon Roger-Gaudry, Université de Montréal, 2900 Edouard-Montpetit, Montreal QC, Canada H3T 1J4. eobrien@bch.umontreal.ca
authors.forename: Emmet A
authors.initials: EA
authors.lastname: O'Brien
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhang
authors.forename: Eric
authors.initials: E
authors.lastname: Wang
authors.forename: Veronique
authors.initials: V
authors.lastname: Marie
authors.forename: Wole
authors.initials: W
authors.lastname: Badejoko
authors.forename: B Franz
authors.initials: BF
authors.lastname: Lang
authors.forename: Gertraud
authors.initials: G
authors.lastname: Burger
mesh_terms: D030541:Databases, Genetic; D050259:Genes, Mitochondrial; D054628:Genome, Chloroplast; D054629:Genome, Mitochondrial; D006801:Humans; D009154:Mutation; D012313:RNA / Q000737:chemistry / Q000378:metabolism; D017393:RNA Editing; D018747:RNA, Chloroplast / Q000737:chemistry / Q000378:metabolism; D000077278:RNA, Mitochondrial
chemical_list: D018747:RNA, Chloroplast; D000077278:RNA, Mitochondrial; D012313:RNA