title: The discovery of equipotent PPARalpha/gamma dual activators.
abstract: We report the design and synthesis of equipotent PPARalpha/gamma dual agonists starting from selective PPAR alpha agonist 1. In vivo data for 7 in the Zucker fa/fa rat are presented.
authors.affiliation: Department of Medicinal Chemistry, Laboratoire GlaxoSmithKline, Centre de Recherches, 25-27 avenue du Québec, 91951 Les Ulis, France. paul.martres@gsk.com
authors.forename: Paul
authors.initials: P
authors.lastname: Martres
authors.forename: Nicolas
authors.initials: N
authors.lastname: Faucher
authors.forename: Alain
authors.initials: A
authors.lastname: Laroze
authors.forename: Olivier
authors.initials: O
authors.lastname: Pineau
authors.forename: Marie Helene
authors.initials: MH
authors.lastname: Fouchet
authors.forename: Florent
authors.initials: F
authors.lastname: Potvain
authors.forename: Didier
authors.initials: D
authors.lastname: Grillot
authors.forename: Veronique
authors.initials: V
authors.lastname: Beneton
mesh_terms: D000818:Animals; D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D015394:Molecular Structure; D047493:PPAR alpha / Q000819:agonists*; D047495:PPAR gamma / Q000819:agonists*; D020033:Protein Isoforms; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D051381:Rats; D011924:Rats, Zucker; D013329:Structure-Activity Relationship
chemical_list: D047493:PPAR alpha; D047495:PPAR gamma; D020033:Protein Isoforms; D011720:Pyrazoles