title: Effectiveness of dexmedetomidine in reducing bleeding during septoplasty and tympanoplasty operations.
abstract: OBJECTIVE
  To determine the effect of dexmedetomidine on intraoperative bleeding during septoplasty and tympanoplasty operations.
  
  
  METHODS
  Randomized, placebo-controlled study.
  
  
  METHODS
  Univesity medical center.
  
  
  METHODS
  80 ASA physical status I and II patients, aged 18 to 65 years, 40 of whom were scheduled for septoplasty and 40 to undergo tympanoplasty operations.
  
  
  METHODS
  Patients undergoing septoplasty (S) and tympanoplasty (T) operations were randomly divided into 4 groups. Dexmedetomidine (D) was administered to Group SD and Group TD first as a bolus dose of one microg kg(-1), then intraoperative maintenance was supplied with dexmedetomidine 0.7 microg kg(-1) hour(-1). Groups S and T (controls) were given identical amounts of saline. If systolic blood pressure measurements are greater than 20% preoperative values, then fentanyl one microg kg(-1) was given.
  
  
  METHODS
  Intraoperative blood loss was determined with suction volumes and gauze counting. Bleeding was rated according to a 6-point scale. Hemodynamic parameters and fentanyl administration were recorded.
  
  
  RESULTS
  Group SD had less bleeding and lower bleeding scores (P < 0.05). In addition, this group received less intraoperative fentanyl (P < 0.05). The only significant difference between Groups TD and T was the amount of intraoperative fentanyl given (35.4 +/- 58.8 vs 110.0 +/- 81.0 microg) (P < 0.05).
  
  
  CONCLUSIONS
  Dexmedetomidine reduces bleeding, bleeding scores, and intraoperative fentanyl consumption during general anesthesia in septoplasty operations.
authors.affiliation: Department of Anaesthesiology and Reanimation, Karaelmas University Faculty of Medicine Zonguldak, Turkey. periayogluzku@yahoo.com
authors.forename: Hilal
authors.initials: H
authors.lastname: Ayoglu
authors.forename: Osman
authors.initials: O
authors.lastname: Yapakci
authors.forename: Mehmet Birol
authors.initials: MB
authors.lastname: Ugur
authors.forename: Lokman
authors.initials: L
authors.lastname: Uzun
authors.forename: Hanife
authors.initials: H
authors.lastname: Altunkaya
authors.forename: Yetkin
authors.initials: Y
authors.lastname: Ozer
authors.forename: Rahsan
authors.initials: R
authors.lastname: Uyanik
authors.forename: Fikret
authors.initials: F
authors.lastname: Cinar
authors.forename: Isil
authors.initials: I
authors.lastname: Ozkocak
mesh_terms: D000293:Adolescent; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000328:Adult; D000368:Aged; D000701:Analgesics, Opioid / Q000627:therapeutic use; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D001794:Blood Pressure / Q000187:drug effects; D020927:Dexmedetomidine / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D005283:Fentanyl / Q000627:therapeutic use; D006400:Hematocrit; D006801:Humans; D008297:Male; D008875:Middle Aged; D009300:Nasal Septum / Q000601:surgery*; D014433:Tympanoplasty
chemical_list: D000316:Adrenergic alpha-Agonists; D000701:Analgesics, Opioid; D020927:Dexmedetomidine; D005283:Fentanyl