[Macro- and micro-element balance in tissue of different organs of experimental animals during their physiological and accelerated (radiation) aging].
By the method of atom-emission spectral analysis with inductive combined argon plasma we researched the containing of Al, Cd, Co, Cu, Fe, Mg, Mn, Mo, P, Pb, S, Zn in lungs, liver, kidneys, spleen and hemispheres of brain of female mice CBA line, aged 26 month and 14 months, and on the accelerated radiation aging model composed of mice of the same age and gender. The process of accelerated radiation aging stimulates accumulation of Al in liver and in kidneys; decreasing of containing Cd in lungs and spleen and increasing it in liver; decreasing of containing Co in lungs and spleen and increasing it in kidneys; decreasing of containing Cu in spleen; decreasing of containing Fe in lungs; decreasing of containing Mg in liver; decreasing of containing Mn in lungs and spleen; decreasing of containing Mo in lungs and spleen and increasing of it in liver and kidneys; the containing of Pb is decreased in lungs and increased in liver; the containing of S is decreased in liver and kidneys, the containing of Zn is decreased in liver and spleen (p < 0.05). The disbalance in macro- and microelements homeostasis relates to the system mechanic of aging process, as it is one of the links of interrelated dysfunction of vital functions both separated molecules and regulation systems of organism. We admitted that part of the changing in the system of macro- and microelements balance is connected with possible function of extra factors (toxic microelements), other part (essential macro- and microelements) is consequence of ontogenetic programs of an organism.
Maksimova
I A
IA
Klimenko
L L
LL
Protasova
O V
OV
D000375:Aging / Q000378:metabolism / Q000502:physiology / Q000528:radiation effects; D019588:Aging, Premature / Q000209:etiology / Q000378:metabolism*; D000818:Animals; D004602:Elements; D005260:Female; D005720:Gamma Rays; D007668:Kidney / Q000378:metabolism* / Q000528:radiation effects; D008099:Liver / Q000378:metabolism* / Q000528:radiation effects; D008168:Lung / Q000378:metabolism* / Q000528:radiation effects; D051379:Mice; D008808:Mice, Inbred CBA; D009928:Organ Specificity; D011829:Radiation Dosage; D013154:Spleen / Q000378:metabolism* / Q000528:radiation effects; D014131:Trace Elements / Q000032:analysis / Q000378:metabolism
D004602:Elements; D014131:Trace Elements