title: [Head and neck sarcoma].
abstract: BACKGROUND
  Head and neck sarcomas comprise a heterogeneous and biologically diverse set of rare neoplasms. The difficulty treating the disease requires multidisciplinary consultation to improve outcome. In an effort to clarify the clinical behavior of head and neck sarcomas and evaluate treatment, we present our experience and review the relevant literature.
  
  
  METHODS
  This is a retrospective analysis of 15 patients with histologically proven head and neck sarcoma treated in the ENT department between 1998 and 2007. All cases were confirmed by histologic exam with immunohistochemical analysis.
  
  
  RESULTS
  Nine women and six men were included in the study. The mean age was 38.4 years (range: 6-73 years). Computed tomography and MRI were done in 66.7% and 60% of the patients, respectively, to evaluate tumor extension. Metastases were demonstrated in three cases. Curative treatment in eight cases was based on different combinations of chemotherapy, radiotherapy, and surgery. Complete remission was obtained in eight cases. Local recurrence was noted in two cases. Two patients died from tumor metastasis. Two patients were lost to follow-up.
  
  
  CONCLUSIONS
  Head and neck sarcomas present diverse rare neoplasms. They make up 5%-20% of all soft tissue sarcomas. All age groups can be affected by this neoplasm, with no predominance in one sex or the other. The most common histologic type is rhabdomyosarcoma, especially in children. Because of the potential for systemic metastasis, extension must be assessed. Treatment is based essentially on the association of surgery, radiotherapy, and chemotherapy to optimize therapeutic results. Five-year survival varies between 44% and 80%.
authors.affiliation: Service ORL et chirurgie cervicofaciale, CHU Habib-Bourguiba, route El-Ain Km 1,5, 3029 Sfax, Tunisie.
authors.forename: B
authors.initials: B
authors.lastname: Hammami
authors.forename: W
authors.initials: W
authors.lastname: Bouayed
authors.forename: W
authors.initials: W
authors.lastname: Siala
authors.forename: N
authors.initials: N
authors.lastname: Toumi
authors.forename: A
authors.initials: A
authors.lastname: Khabir
authors.forename: T
authors.initials: T
authors.lastname: Boudawara
authors.forename: M
authors.initials: M
authors.lastname: Frikha
authors.forename: J
authors.initials: J
authors.lastname: Daoud
authors.forename: I
authors.initials: I
authors.lastname: Charfeddine
authors.forename: A
authors.initials: A
authors.lastname: Ghorbel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D012074:Remission Induction; D012189:Retrospective Studies; D012509:Sarcoma / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D013997:Time Factors; D014057:Tomography, X-Ray Computed