An open study of antibiotics for the treatment of pre-pouch ileitis following restorative proctocolectomy with ileal pouch-anal anastomosis.
BACKGROUND
Pre-pouch ileitis is a recently described condition which may occur following restorative proctocolectomy. Its aetiology remains unknown and only one study has reported the effect of treatment. We report a series of fourteen patients treated and followed up with repeat pouchoscopy.


OBJECTIVE
To study the effectiveness of antibiotics for the treatment of pre-pouch ileitis following restorative proctocolectomy with ileal pouch-anal anastomosis.


METHODS
Fourteen consecutive patients with symptomatic pre-pouch ileitis were treated with ciprofloxacin 500 mg b.d. and metronidazole 400 mg b.d. for 28 days. All had concurrent pouchitis. Symptomatic, endoscopic and histological assessment was performed before and following treatment using the pouchitis disease activity index (PDAI). Symptomatic remission was defined as a score of 0 in the clinical component of the PDAI.


RESULTS
Twelve (86%) patients experienced symptomatic remission. Stool frequency fell from a median of 12 (range 8-20) to 6 (4-17) (P = 0.002). There was a significant reduction in the anatomical length of pre-pouch ileitis with nine (64%) patients having either a resolution or a reduction in length of pre-pouch ileitis from a median of 10 cm (range 3-20 cm) to a median of 1 cm (range 0-10 cm) (P = 0.007).


CONCLUSIONS
Combination antibiotic therapy in this uncontrolled study appears effective in reducing the length of pre-pouch ileitis and in inducing symptomatic remission in most patients whether or not its extent is reduced.
McLaughlin
S D
SD
Department of Biosurgery and Surgical Technology, Imperial College London, Loondon, UK. simon.mclaughlin@nhs.net
Clark
S K
SK
Bell
A J
AJ
Tekkis
P P
PP
Ciclitira
P J
PJ
Nicholls
R J
RJ
D000328:Adult; D001003:Anal Canal / Q000601:surgery; D000714:Anastomosis, Surgical / Q000009:adverse effects; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007082:Ileum / Q000601:surgery; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use*; D008875:Middle Aged; D019449:Pouchitis / Q000188:drug therapy*; D016737:Proctocolectomy, Restorative / Q000009:adverse effects*; D012720:Severity of Illness Index; D013223:Statistics as Topic; D016896:Treatment Outcome; D055815:Young Adult
D000900:Anti-Bacterial Agents; D008795:Metronidazole; D002939:Ciprofloxacin