FMRI indices of auditory attention in schizophrenia.
The present study sought to identify abnormalities in activation in several brain regions in response to an auditory attention task in patients with schizophrenia. Ten patients and twenty healthy control participants were examined using Functional Magnetic Resonance Imaging (FMRI) measures acquired during an auditory attention task. Region of interest analyses of activation of targeted regions implicated in attention included: anterior cingulate cortex (ACC), dorsolateral prefrontal cortex (DLPFC), hippocampus, parahippocampal gyrus (PHG), and superior temporal gyrus (STG). The results indicated over-activation in patients with schizophrenia. While the control group showed notable coherence in activation within and across hemispheres the schizophrenia group showed relatively less coherence overall that was only present in the right hemisphere. These findings suggest that patients with schizophrenia show both an over-engagement of brain regions during attention task as well as a lack of communication among neural regions involved.
Schirmer
Todd N
TN
Department of Psychology, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, Illinois 60064, USA. todd_schirmer@yahoo.com
Dorflinger
Jill M
JM
Marlow-O'Connor
Megan
M
Pendergrass
Jo Cara
JC
Hartzell
Aileen
A
All
Sherrie D
SD
Charles
David
D
D000161:Acoustic Stimulation; D000328:Adult; D001288:Attention; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology*; D005260:Female; D007839:Functional Laterality; D006624:Hippocampus / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000523:psychology*; D008297:Male; D008959:Models, Neurological; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology