Alphav integrins lead the way for colorectal metastases.
In this issue of Clinical Cancer Research, Conti et al. identify a crucial cell adhesion and signaling axis that promotes the proliferation, survival, and drug-resistant properties of metastatic colorectal cancer cells in the liver. The components of this pathway may be effective targets for therapeutically treating established metastatic tumors in patients with colorectal adenocarcinomas.
McCarty
Joseph H
JH
Department of Cancer Biology, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA. jhmccarty@mdanderson.org
D000230:Adenocarcinoma / Q000378:metabolism* / Q000556:secondary / Q000601:surgery; D002448:Cell Adhesion; D049109:Cell Proliferation; D002470:Cell Survival; D024042:Collagen Type I / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology; D019008:Drug Resistance, Neoplasm; D006498:Hepatectomy; D006801:Humans; D039564:Integrin alphaV / Q000502:physiology*; D008113:Liver Neoplasms / Q000378:metabolism* / Q000556:secondary / Q000601:surgery
D024042:Collagen Type I; D039564:Integrin alphaV