Potential analgesic and anti-inflammatory activities of Panax ginseng head butanolic fraction in animals.
The present study reports the potential anti-rheumatoid activity of Panax ginseng head part. P. ginseng-head part BuOH fraction (PGHB) was safe in acute toxicity (LD(50)>5000mg/kg) and inhibited the partially acetic acid-induced writhes (approximately 32%, P<0.05) in mice. PGHB (500mg/kg) inhibited the acetic acid-induced extravasation of Evan's blue dye in mice by approximately 20.6% (P<0.05), and was similar to the suppressive effect of ibuprofen (27.7%) as a positive control drug. Also, PGHB reduced the carrageenan-induced paw edema at 3h after oral administration, and suppressed the production of serum IL-6 in CIA mice. This suggests that PGHB has potential analgesic and anti-inflammatory activities, and will be the supporting evidence for the potential anti-rheumatoid activity of Korean P. ginseng-head.
Lee
Je-Hyuk
JH
Plant Resources Research Institute, Duksung Women's University, Seoul 132-714, Republic of Korea.
Lee
Jung-Hun
JH
Lee
Yu-Mi
YM
Kim
Pit-Na
PN
Jeong
Choon-Sik
CS
D019342:Acetic Acid; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001835:Body Weight / Q000187:drug effects; D000440:Butanols; D002199:Capillary Permeability / Q000187:drug effects; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D015850:Interleukin-6 / Q000378:metabolism; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009929:Organ Size / Q000187:drug effects; D010147:Pain Measurement / Q000187:drug effects; D005894:Panax / Q000737:chemistry* / Q000633:toxicity; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012997:Solvents; D013154:Spleen / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000440:Butanols; D015850:Interleukin-6; D010936:Plant Extracts; D012997:Solvents; D002351:Carrageenan; D019342:Acetic Acid