Sulfated modification of the water-soluble polysaccharides from Polyporus albicans mycelia and its potential biological activities.
In this study, three chemically sulfated polysaccharides (SPAPs) were derived from one water-soluble polysaccharide (PAP) of Polyporus albicans mycelia by chlorosulfonic acid-pyridine method. The effects of polysaccharides on the immune function were examined after the mice were intragastrical administrated with polysaccharides at three doses of 100, 200, and 300 mg/kg body weight for 7 days. The results showed that both the lymphocytes proliferation and macrophage function were significantly enhanced by SPAP in all groups along with the increase of the substitution degree and dose (P<0.01). It indicated that SPAP could be a potential immunostimulants used in the food and pharmaceutical industry.
Sun
Yongxu
Y
Department of Pharmacology, Qiqihar Medical University, Qiqihar 161042, China. yongxusun1978@yahoo.com.cn
Liang
Haitao
H
Cai
Guangzhi
G
Guan
Shuwen
S
Tong
Haibin
H
Yang
Xiudong
X
Liu
Jicheng
J
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000737:chemistry*; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D008214:Lymphocytes / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D055492:Polyporus / Q000737:chemistry*; D011134:Polysaccharides / Q000008:administration & dosage / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry; D013451:Sulfonic Acids / Q000737:chemistry
D000276:Adjuvants, Immunologic; D011134:Polysaccharides; D011725:Pyridines; D013451:Sulfonic Acids; C013880:chlorosulfonic acid; C023666:pyridine