title: Effect of ripe fruit pulp extract of Cucurbita pepo Linn. in aspirin induced gastric and duodenal ulcer in rats.
abstract: A significant decrease in alkaline phosphatase (AP) activity and mucosal thickness and increase in ulcer index (UI) was observed in aspirin treated stomach and duodenum of albino rats. However, pretreatment with C. pepo fruit pulp extract for 14 consecutive days showed increase in AP activity and mucosal thickness along with decrease in UI, suggesting gastroduodenal protective and anti-ulcerogenic properties of C. pepo.
authors.affiliation: S.N. Pradhan Centre for Neurosciences, University of Calcutta 244B, A.J.C. Bose Road, Kolkata 700 020, India.
authors.forename: Sentu
authors.initials: S
authors.lastname: Sarkar
authors.forename: Debjani
authors.initials: D
authors.lastname: Buha
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D001241:Aspirin / Q000494:pharmacology*; D028464:Cucurbita / Q000737:chemistry* / Q000254:growth & development; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005638:Fruit / Q000737:chemistry* / Q000254:growth & development; D008297:Male; D010936:Plant Extracts / Q000737:chemistry* / Q000627:therapeutic use*; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D001241:Aspirin