Making connections at DNA replication forks: Mrc1 takes the lead.
In a recent issue of Molecular Cell, Lou et al. (2008) demonstrate that the Mrc1 protein associates with the DNA polymerase that acts on the leading strand at replication forks, suggesting a potential mechanism that could help to preserve genome stability.
Labib
Karim
K
Cancer Research UK, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.
D018797:Cell Cycle Proteins / Q000378:metabolism / Q000502:physiology*; D004265:DNA Helicases / Q000378:metabolism; D004257:DNA Polymerase II / Q000378:metabolism; D004261:DNA Replication / Q000502:physiology*; D004271:DNA, Fungal / Q000096:biosynthesis* / Q000378:metabolism; D010766:Phosphorylation; D012441:Saccharomyces cerevisiae / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism / Q000502:physiology*
D018797:Cell Cycle Proteins; D004271:DNA, Fungal; C441579:MRC1 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D004257:DNA Polymerase II; D004265:DNA Helicases