title: Efficient 1,4-addition of alpha-substituted fluoro(phenylsulfonyl)methane derivatives to alpha,beta-unsaturated compounds.
abstract: The 1,4-addition of a monofluoromethyl nucleophile to a variety of alpha,beta-unsaturated compounds has been achieved under mild conditions using either phosphines or potassium carbonate at room temperature. alpha-Substituted fluoro(phenylsulfonyl)methane easily undergoes Michael addition to alpha,beta-unsaturated ketones, esters, nitriles, sulfones, as well as propynoates at room temperature to yield the corresponding adducts in moderate to excellent yields.
authors.affiliation: Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, Los Angeles, California 90089-1661, USA. gprakash@usc.edu
authors.forename: G K Surya
authors.initials: GK
authors.lastname: Prakash
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Zhao
authors.forename: Sujith
authors.initials: S
authors.lastname: Chacko
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: Habiba
authors.initials: H
authors.lastname: Vaghoo
authors.forename: George A
authors.initials: GA
authors.lastname: Olah