Melanocytoma in the orbital apex.
We report a case of a 49-year-old man presenting with a melanocytoma located in the orbital apex. The tumor was subtotally removed and adjuvant chemotherapy was given. The patient has remained under follow-up for the past 12 years without any evidence of recurrence. Although the characteristic neuroradiological images of the lesion prove the presence of melanin, histological examination is crucial to establish the diagnosis of melanocytoma. Besides the clinical and neuroradiological presentation, the histological, immunohistochemical, and ultrastructural findings are described. To our knowledge, this is the second published case of intraorbital melanocytoma initially confined to the orbital apex. Melanocytoma should be included in the differential diagnosis of intraorbital tumors in such a location.
Sato
Kazufumi
K
Division of Neurosurgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Science, University of Fukui, 23 Shimoaizuki, Matsuoka, Eiheiji-cho,Yoshida-gun, 910-1193, Fukui, Japan. ksato@u-fukui.ac.jp
Kubota
Toshihiko
T
Kodera
Toshiaki
T
Kitai
Ryuhei
R
Takeuchi
Hiroaki
H
Yoshida
Kazuhiko
K
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003606:Dacarbazine / Q000008:administration & dosage; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D016899:Interferon-beta / Q000008:administration & dosage; D008297:Male; D008544:Melanocytes / Q000378:metabolism / Q000473:pathology*; D008545:Melanoma / Q000473:pathology; D008577:Meningeal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D008875:Middle Aged; D019635:Neurosurgical Procedures; D015376:Nimustine / Q000008:administration & dosage; D009918:Orbital Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D014057:Tomography, X-Ray Computed; D014750:Vincristine / Q000008:administration & dosage
D015376:Nimustine; D014750:Vincristine; D016899:Interferon-beta; D003606:Dacarbazine