Death by splicing: tumor suppressor RBM5 freezes splice-site pairing.
In a recent issue of Molecular Cell, Bonnal et al. (2008) demonstrate that the tumor suppressor gene RBM5 regulates alternative splicing of Fas pre-mRNA by interfering with splice-site pairing.
Kotlajich
Matthew V
MV
Department of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA 92697-4025, USA.
Hertel
Klemens J
KJ
D017398:Alternative Splicing; D017209:Apoptosis / Q000235:genetics*; D018797:Cell Cycle Proteins / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000502:physiology*; D005091:Exons; D006801:Humans; D007438:Introns; D008957:Models, Genetic; D020033:Protein Isoforms / Q000378:metabolism; D012322:RNA Precursors / Q000378:metabolism; D022821:RNA Splice Sites; D012333:RNA, Messenger / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000502:physiology*; D019014:fas Receptor / Q000235:genetics / Q000378:metabolism*
D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; C491901:FAS protein, human; D020033:Protein Isoforms; C473448:RBM5 protein, human; D012322:RNA Precursors; D022821:RNA Splice Sites; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D025521:Tumor Suppressor Proteins; D019014:fas Receptor