Recurrent varicella zoster virus myelopathy.
Myelopathy is an uncommon complication of VZV infection and may develop in the absence of rash. We report the rare recurrence of myelopathy in an immunocompetent adult who initially developed myelopathy after ophthalmic-distribution zoster. Recurrent myelopathy two years later caused by VZV was verified by the presence of new-onset clinical symptoms and signs consistent with myelopathy, new lesions in the spinal cord detected by MRI, and evidence of intrathecal synthesis of anti-VZV IgG antibody in CSF. After virological verification and antiviral therapy, myelopathy did not recur and anti-VZV IgG antibody could not be detected in CSF. In contrast to earlier cases of recurrent VZV myelopathy in immunocompetent adults that developed weeks to months after the first episode of myelopathy, this is the first instance of recurrence years later.
Gilden
Don
D
Department of Neurology, University of Colorado Denver, School of Medicine, Denver, CO, USA. don.gilden@uchsc.edu
Nagel
Maria A
MA
Ransohoff
Richard M
RM
Cohrs
Randall J
RJ
Mahalingam
Ravi
R
Tanabe
Jody L
JL
D018450:Disease Progression; D020804:Encephalitis, Varicella Zoster / Q000150:complications* / Q000276:immunology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D013118:Spinal Cord Diseases / Q000209:etiology* / Q000473:pathology / Q000821:virology*