title: Gold nanoparticles functionalised by Gd-complex of DTPA-bis(amide) conjugate of glutathione as an MRI contrast agent.
abstract: The work is directed toward the synthesis of gold nanoparticles (Au NPs) coated with paramagnetic Gd-complex of DTPA-bis(amide) conjugate of glutathione (GdL) for use as a highly efficient MRI contrast agent. Well-dispersed spherical Au NPs coated with gadolinium complexes, abbreviated as Au@GdL, have been obtained; the mean size of Au@GdL is 5-7 nm, and the numbers of GdL are 1.36x10(4) per Au NP. Au@GdL exhibits high longitudinal (r1) and transverse (r2) relaxivities of 1.87x10(5) and 3.02x10(5) mM(-1) s(-1), respectively.
authors.affiliation: Department of Medical & Biological Engineering, Kyungpook National University, Daegu, Republic of Korea.
authors.forename: Ji-Ae
authors.initials: JA
authors.lastname: Park
authors.forename: Pattubala A N
authors.initials: PA
authors.lastname: Reddy
authors.forename: Hee-Kyung
authors.initials: HK
authors.lastname: Kim
authors.forename: In-Sung
authors.initials: IS
authors.lastname: Kim
authors.forename: Gab-Chul
authors.initials: GC
authors.lastname: Kim
authors.forename: Yongmin
authors.initials: Y
authors.lastname: Chang
authors.forename: Tae-Jeong
authors.initials: TJ
authors.lastname: Kim
mesh_terms: D003287:Contrast Media / Q000737:chemistry*; D019786:Gadolinium DTPA / Q000031:analogs & derivatives* / Q000737:chemistry; D005978:Glutathione; D006046:Gold / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D053758:Nanoparticles; D009942:Organometallic Compounds / Q000737:chemistry*
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D006046:Gold; D005978:Glutathione; D019786:Gadolinium DTPA