Current cellular immunological hurdles in pig-to-primate xenotransplantation.
In this review, we summarize the work published over the last few years relative to cellular immunological hurdles encountered specifically in pig-to-primate xenotransplantation models. The works summarized here cover both the innate and adaptative cellular immune response as well as strategies to overcome them and consequently prevent xenograft rejection.
Le Bas-Bernardet
Stéphanie
S
INSERM, U643, Nantes, France.
Blancho
Gilles
G
D000818:Animals; D000910:Antibodies, Heterophile / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D006084:Graft Rejection / Q000276:immunology* / Q000517:prevention & control; D006801:Humans; D007111:Immunity, Cellular; D056724:Immunity, Humoral; D007113:Immunity, Innate; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation; D016131:Lymphocyte Subsets / Q000276:immunology; D011323:Primates; D015398:Signal Transduction; D013552:Swine; D014183:Transplantation, Heterologous / Q000276:immunology*
D000910:Antibodies, Heterophile