title: Organelle positioning and cell polarity.
abstract: In spite of conspicuous differences in their polarized architecture, swimming unicellular eukaryotes and migrating cells from metazoa display a conserved hierarchical interlocking of the main cellular compartments, in which the microtubule network has a dominant role. A microtubule array can organize the distribution of endomembranes owing to a cell-wide and polarized extension around a unique nucleus-associated structure. The nucleus-associated structure in animal cells contains a highly conserved organelle, the centriole or basal body. This organelle has a defined polarity that can be transmitted to the cell. Its conservative mode of duplication seems to be a core mechanism for the transmission of polarities through cell division.
authors.affiliation: Compartimentation et Dynamique Cellulaires, UMR144 CNRS-Institut Curie, 26 rue d'Ulm, 75 248, Paris cedex 05, France. michel.bornens@curie.fr
authors.forename: Michel
authors.initials: M
authors.lastname: Bornens
mesh_terms: D000818:Animals; D016764:Cell Polarity; D006801:Humans; D015388:Organelles / Q000378:metabolism*; D015003:Yeasts