Sleep loss produces false memories.
People sometimes claim with high confidence to remember events that in fact never happened, typically due to strong semantic associations with actually encoded events. Sleep is known to provide optimal neurobiological conditions for consolidation of memories for long-term storage, whereas sleep deprivation acutely impairs retrieval of stored memories. Here, focusing on the role of sleep-related memory processes, we tested whether false memories can be created (a) as enduring memory representations due to a consolidation-associated reorganization of new memory representations during post-learning sleep and/or (b) as an acute retrieval-related phenomenon induced by sleep deprivation at memory testing. According to the Deese, Roediger, McDermott (DRM) false memory paradigm, subjects learned lists of semantically associated words (e.g., "night", "dark", "coal",...), lacking the strongest common associate or theme word (here: "black"). Subjects either slept or stayed awake immediately after learning, and they were either sleep deprived or not at recognition testing 9, 33, or 44 hours after learning. Sleep deprivation at retrieval, but not sleep following learning, critically enhanced false memories of theme words. This effect was abolished by caffeine administration prior to retrieval, indicating that adenosinergic mechanisms can contribute to the generation of false memories associated with sleep loss.
Diekelmann
Susanne
S
Department of Neuroendocrinology, University of Lübeck, Lübeck, Germany. diekelmann@kfg.uni-luebeck.de
Landolt
Hans-Peter
HP
Lahl
Olaf
O
Born
Jan
J
Wagner
Ullrich
U
D000293:Adolescent; D000328:Adult; D002110:Caffeine / Q000494:pharmacology; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis / Q000378:metabolism; D007858:Learning / Q000187:drug effects / Q000502:physiology; D008297:Male; D008569:Memory Disorders / Q000209:etiology*; D011939:Mental Recall / Q000187:drug effects / Q000502:physiology; D012463:Saliva / Q000737:chemistry; D012892:Sleep Deprivation / Q000503:physiopathology* / Q000523:psychology*; D013315:Stress, Psychological / Q000378:metabolism / Q000503:physiopathology; D013647:Task Performance and Analysis; D055815:Young Adult
D002110:Caffeine; D006854:Hydrocortisone