An animal model of chemotherapy-induced vagal neuropathy.
In this study we establish an animal model of chemotherapy-induced autonomic neuropathy. Rats were injected with vincristine (30 and 100 microg/kg/day) for 2 weeks while cardiovascular parameters were collected telemetrically. Vincristine caused a dose-dependent decrease in vagal activity expressed by decreased parasympathetic parameters of heart rate variability, without expression of damage to the cardiac sympathetic innervation. This model can serve in assessing the potential contribution of chemotherapy-induced vagal neuropathy to morbidity and mortality.
Weissman-Fogel
Irit
I
Faculty of Social Welfare and Health Sciences, University of Haifa, Israel.
Dashkovsky
Arkadi
A
Rogowski
Zeev
Z
Yarnitsky
David
D
D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects; D001342:Autonomic Nervous System Diseases / Q000139:chemically induced / Q000503:physiopathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006439:Hemodynamics / Q000502:physiology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D020421:Vagus Nerve Diseases / Q000139:chemically induced* / Q000503:physiopathology; D014750:Vincristine / Q000009:adverse effects
D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D014750:Vincristine