Distal clearance margin of 1 cm or less: a safe distance in lower rectum cancer surgery.
OBJECTIVE
The purpose of this study was to investigate the prognostic role of distal clearance margin (DCM) in lower rectum cancer surgery.


METHODS
Two-hundred-three cancer patients underwent total rectal resection, possibly followed by adjuvant chemoradiotherapy. DCM was classified as positive or negative (<1, > or =1 cm) and investigated with multivariable proportional hazard models.


RESULTS
A total of 52 deaths, 19 local relapses, 40 distant metastases, and three second primaries were observed as first events. Five-year survival with positive, negative <1, or negative > or =1 cm DCM was 51%, 81%, and 69%, respectively (p = 0.018). The difference was significant between positive and negative DCM (p = 0.031), not between negative <1 and > or =1 cm (p = 0.106). Local and distant 5-year incidences according to DCM were 30%, 8%, and 8% (p = 0.006) and 38%, 26%, and 19% (p = 0.857), respectively.


CONCLUSIONS
DCM, but not tumor size, is a prognostic factor after sphincter-saving surgery, which is safe whenever a negative margin is achieved.
Leo
Ermanno
E
Division of Colorectal Surgery, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
Belli
Filiberto
F
Miceli
Rosalba
R
Mariani
Luigi
L
Gallino
GianFrancesco
G
Battaglia
Luigi
L
Vannelli
Alberto
A
Andreola
Salvatore
S
D000368:Aged; D005260:Female; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D016016:Proportional Hazards Models; D012004:Rectal Neoplasms / Q000453:epidemiology / Q000601:surgery*; D012008:Recurrence; D016019:Survival Analysis