title: Incidental cases of subacute cutaneous lupus erythematosus in association with malignancy.
abstract: Malignancy and chronic inflammatory diseases seem to be associated to one another. Here we review the literature regarding subacute cutaneous lupus erythematosus (SCLE) and concomitant neoplasia on the basis of 3 short case reports of patients with SCLE who developed breast cancer and lung cancer respectively after long-term disease activity and immunosuppressive therapy. Possible hypotheses for this co-incidence could be: i) malignancy as a consequence of chronic inflammation, ii) malignancy as a consequence of immunosuppressive therapy, iii) paraneoplastic disease, iv) local malignancy following a persisting proliferative or reparative process or v) only coincidental occurrence.
authors.affiliation: Clinic of Dermatology, Venereology und Allergology, University of Leipzig Ph.-Rosenthalstr. 23-25, 04103 Leipzig, Germany. regina.renner@medizin.uni-leipzig.de
authors.forename: Regina
authors.initials: R
authors.lastname: Renner
authors.forename: Michael
authors.initials: M
authors.lastname: Sticherling
mesh_terms: D001943:Breast Neoplasms / Q000150:complications*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications*; D008178:Lupus Erythematosus, Cutaneous / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D008875:Middle Aged