Tailoring beta-cyclodextrin for DNA complexation and delivery by homogeneous functionalization at the secondary face.
An efficient general strategy for the incorporation of functional elements onto the secondary hydroxyl rim of beta-cyclodextrin has been developed and applied to the synthesis of a novel series of C7-symmetric homogeneous macromolecular polycations with improved DNA complexing and delivery properties.
Ortega-Caballero
Fernando
F
Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Sevilla, Spain.
Mellet
Carmen Ortiz
CO
Le Gourriérec
Loïc
L
Guilloteau
Nicolas
N
Di Giorgio
Christophe
C
Vierling
Pierre
P
Defaye
Jacques
J
García Fernández
José M
JM
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000378:metabolism*; D051379:Mice; D014162:Transfection; D047392:beta-Cyclodextrins / Q000138:chemical synthesis* / Q000378:metabolism* / Q000633:toxicity
D047392:beta-Cyclodextrins; D004247:DNA; C031215:betadex