[Comparative estimation of pharmacokinetics of generic ribavirin-containing drugs].
Bioequivalence of the new Russian oral ribavirin-containing agents was estimated by the pharmacokinetic and bioavailability parameters vs. the original agent Rebetol. The agents were administered orally in single doses. The ribavirin blood levels were determined by HPLH. It was shown that the main pharmacokinetic parameters did not significantly differ. The agents proved to be bioequivalent.
Pisarev
V V
VV
Smirnova
L B
LB
Savchenko
A Iu
AIu
Nisrin
Azaam
A
D000328:Adult; D000998:Antiviral Agents / Q000493:pharmacokinetics*; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D016568:Drugs, Generic / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D012254:Ribavirin / Q000493:pharmacokinetics*
D000998:Antiviral Agents; D016568:Drugs, Generic; D012254:Ribavirin