Unusual clustering of coefficients of variation in published articles from a medical biochemistry department in India.
A simple statistical method is described to test whether data are consistent with minimum statistical variability expected in a biological experiment. The method is applied to data presented in data tables in a subset of 84 articles among more than 200 published by 3 investigators in a small medical biochemistry department at a major university in India and to 29 "control" articles selected by key word PubMed searches. Major conclusions include: 1) unusual clustering of coefficients of variation (CVs) was observed for data from the majority of articles analyzed that were published by the 3 investigators from 2000-2007; unusual clustering was not observed for data from any of their articles examined that were published between 1992 and 1999; and 2) among a group of 29 control articles retrieved by PubMed key word, title, or title/abstract searches, unusually clustered CVs were observed in 3 articles. Two of these articles were coauthored by 1 of the 3 investigators, and 1 was from the same university but a different department. We are unable to offer a statistical or biological explanation for the unusual clustering observed.
Hudes
Mark L
ML
Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way. Oakland, CA 94609, USA.
McCann
Joyce C
JC
Ames
Bruce N
BN
D001671:Biochemistry; D007194:India; D015233:Models, Statistical; D011643:Publishing / Q000706:statistics & numerical data*; D012106:Research / Q000592:standards*; D013223:Statistics as Topic; D014495:Universities