Isolation, structure and fatty acid synthesis inhibitory activities of platensimycin B1-B3 from Streptomyces platensis.
Platensimycins B(1)-B(3) are natural congeners of platensimycin with modest to significant changes in the benzoic acid portion of the molecule, leading to attenuation in the biological activities and thus confirming the significance of the free carboxylate for the potent activity.
Zhang
Chaowei
C
Merck Research Laboratories, Rahway, New Jersey 07065, USA.
Ondeyka
John
J
Zink
Deborah L
DL
Burgess
Bruce
B
Wang
Jun
J
Singh
Sheo B
SB
D015099:3-Oxoacyl-(Acyl-Carrier-Protein) Synthase / Q000037:antagonists & inhibitors / Q000378:metabolism; D000218:Adamantane / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D062365:Aminobenzoates / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D000813:Anilides / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D005227:Fatty Acids / Q000096:biosynthesis*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000201:enzymology; D013302:Streptomyces / Q000737:chemistry*
D062365:Aminobenzoates; D000813:Anilides; D000900:Anti-Bacterial Agents; D005227:Fatty Acids; D015099:3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; D000218:Adamantane; C510909:platensimycin