title: The promise and perils of an Alzheimer disease vaccine: a video debate.
abstract: Alzheimer's disease (AD) is a critical health care problem that has considerable social and economic impact on society. Effective treatments have been elusive. One major causal factor for the disease is believed to be the deposition of amyloid fibrils in the brain, which ultimately leads to neurodegeneration and cognitive dysfunction. Based on the amyloid hypothesis of Alzheimer's disease, many therapies presently target the amyloid beta (Abeta) peptide, the monomeric protein fragment that assembles to form fibrils. This video article takes the form of a debate between Dr. Morgan and Dr. Landreth on the merits and drawbacks of an Alzheimer's disease vaccine. Click on Supplemental Material to watch the streaming video.
authors.affiliation: Department of Molecular Pharmacology and Physiology, School of Biomedical Sciences, College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd, Tampa, FL 33612, USA. scientist.dave@gmail.com
authors.forename: Dave
authors.initials: D
authors.lastname: Morgan
authors.forename: Gary
authors.initials: G
authors.lastname: Landreth
authors.forename: Paula
authors.initials: P
authors.lastname: Bickford
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000276:immunology* / Q000517:prevention & control* / Q000523:psychology; D023582:Alzheimer Vaccines / Q000009:adverse effects* / Q000627:therapeutic use*; D016229:Amyloid beta-Peptides / Q000276:immunology / Q000378:metabolism; D000818:Animals; D003071:Cognition / Q000502:physiology; D006801:Humans; D051379:Mice; D016896:Treatment Outcome
chemical_list: D023582:Alzheimer Vaccines; D016229:Amyloid beta-Peptides