title: Policies and practices for the clinical management of HIV/HCV coinfected children in Europe: an epidemiological survey.
abstract: The antenatal prevalence of HIV/HCV coinfection ranges from 12% to 28% with mother-to-child transmission rates ranging from 3.6% to 9.5%. There are no guidelines detailing the most appropriate clinical management and treatment of coinfected children. We used a semi-structured questionnaire to investigate current European practices for the management and follow-up of HIV/HCV coinfected children among clinical centres contributing to the European Collaborative Study or the European Paediatric HCV Network. Clinicians from 16 out of 24 clinical centres responded and were caring for a total of 44 HIV/HCV coinfected children. We found that, although there was a high level of concordance regarding testing for HIV and/or HCV infection, monitoring practices in these European centres varied widely. Few clinicians stated they would administer HIV and HCV treatment concurrently. Limited experience in the clinical management of this group and the lack of an evidence base to guide policy may be a barrier to achieving optimal care and treatment.
authors.affiliation: MRC Centre of Epidemiology for Child Health, Institute of Child Health, University College London, London, UK. k.england@ich.ucl.ac.uk
authors.forename: Kirsty
authors.initials: K
authors.lastname: England
authors.forename: Claire
authors.initials: C
authors.lastname: Thorne
authors.forename: Lucy
authors.initials: L
authors.lastname: Pembrey
authors.forename: Marie-Louise
authors.initials: ML
authors.lastname: Newell
mesh_terms: D000293:Adolescent; D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage; D000998:Antiviral Agents / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D016903:Drug Monitoring; D004359:Drug Therapy, Combination; D005060:Europe / Q000453:epidemiology; D015658:HIV Infections / Q000188:drug therapy* / Q000453:epidemiology; D019538:Health Care Surveys; D006526:Hepatitis C / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D007223:Infant; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'
chemical_list: D019380:Anti-HIV Agents; D000998:Antiviral Agents