Synergistic effect of Kalpaamruthaa on antiarthritic and antiinflammatory properties--its mechanism of action.
The present study was designed to evaluate the antiinflammatory properties of Kalpaamruthaa (KA) a modified indigenous Siddha formulation constituting Semecarpus anacardium nut milk extract (SA), Emblica officinalis (EO) and honey in acute and chronic antiinflammatory studies. A dose of 150 mg/kg b.wt. of SA and KA were used for the present studies. The effect of KA was compared with standard drug diclofenac sodium. It was observed that the drug KA exhibited enhanced effect on antiinflammatory and antiarthritic properties than sole SA treatment and the collective effect of KA might be due to the combined interactions of the phytochemicals such as flavonoids, tannins and other compounds such as vitamin c present in KA.
Mythilypriya
Rajendran
R
Department of Medical Biochemistry, Dr. ALM. Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, India.
Shanthi
Palanivelu
P
Sachdanandam
Panchanadam
P
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001169:Arthritis, Experimental / Q000209:etiology / Q000517:prevention & control*; D002351:Carrageenan; D032561:Cotton Fiber; D004008:Diclofenac / Q000494:pharmacology; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D005620:Freund's Adjuvant; D007249:Inflammation / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D008515:Medicine, Ayurvedic; D009754:Nuts; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D031023:Semecarpus; D013997:Time Factors
D000893:Anti-Inflammatory Agents; C510231:Kalpaamruthaa; D010936:Plant Extracts; D004008:Diclofenac; D002351:Carrageenan; D005620:Freund's Adjuvant