Immunoglobulin expression and its biological significance in cancer cells.
It is generally believed that the expression of a gene is restricted "within the right place and at the right time". This principle has long been considered applicable as well to the expression of immunoglobulin (Ig) lymphocytes of B cell lineage. However, increasing evidence has shown Ig "paradoxically" expressed in malignant tumors of epithelial origin. We reviewed the recent progress in the study of cancer-derived Ig, and also discussed its mechanisms and possible functions, trying to arouse interest and attention to those working in the field of immunology and oncology.
Hu
Duosha
D
Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Zheng
Hui
H
Liu
Haidan
H
Li
Ming
M
Ren
Wei
W
Liao
Wei
W
Duan
Zhi
Z
Li
Lili
L
Cao
Ya
Y
D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D019070:Cell Lineage / Q000276:immunology; D022801:Complementarity Determining Regions; D006801:Humans; D017578:Immunoglobulin Class Switching; D007136:Immunoglobulins / Q000096:biosynthesis / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology* / Q000378:metabolism; D050441:VDJ Exons
D022801:Complementarity Determining Regions; D007136:Immunoglobulins