Hepatoprotective effect of Hibiscus hispidissimus Griffith, ethanolic extract in paracetamol and CCl4 induced hepatotoxicity in Wistar rats.
Hibiscus hispidissimus Griff. is used in tribal medicine of Kerala, the southern most state of India, to treat liver diseases. In the present study, the effect of the ethanolic extract of Hibiscus hispidissimus whole plant on paracetamol (PCM)-induced and carbon tetrachloride (CCl4)-induced liver damage in healthy Wistar albino rats was studied. The results showed that significant hepatoprotective effects were obtained against liver damage induced by PCM and CCl4 as evidenced by decreased levels of serum enzymes, glutamate oxaloacetate transaminase (SGOT), glutamate pyruvate transaminase (SGPT), serum alkaline phosphatase (SAKP), serum bilirubin (SB) and an almost normal histological architecture of the liver of the treated groups compared to the toxin controls. The extract also showed significant antilipid peroxidant effects in vitro, besides exhibiting significant activity in quenching 1, 1-diphenyl-2-picryl hydrazyl (DPPH) radical, indicating its potent antioxidant effects.
Krishnakumar
N M
NM
Presentation College of Applied Sciences, Puthenvelikkara, Ernakulam 683 594, India.
Latha
P G
PG
Suja
S R
SR
Shine
V J
VJ
Shyamal
S
S
Anuja
G I
GI
Sini
S
S
Pradeep
S
S
Shikha
P
P
Unni
P K Somasekharan
PK
Rajasekharan
S
S
D000082:Acetaminophen / Q000633:toxicity*; D000818:Animals; D001713:Biphenyl Compounds / Q000494:pharmacology; D002251:Carbon Tetrachloride / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury; D000431:Ethanol; D016166:Free Radical Scavengers / Q000378:metabolism; D031584:Hibiscus / Q000737:chemistry*; D015227:Lipid Peroxidation / Q000187:drug effects; D008107:Liver Diseases / Q000201:enzymology / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D010851:Picrates / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; D010936:Plant Extracts; D000082:Acetaminophen; D000431:Ethanol; D002251:Carbon Tetrachloride; C004931:1,1-diphenyl-2-picrylhydrazyl