[Eosinophilic esophagitis in the adult--clinical, endoscopic, pH-metric, and manometric findings].
OBJECTIVE
Eosinophilic esophagitis (EE) is a condition characterized by dysphagia and frequent food impaction in young adults. The aim of our study was to evaluate the clinical aspects, endoscopic features, pH-metric and motility disorders in EE.


METHODS
Adult patients with EE were prospectivity included. Endoscopy with biopsy, stationary esophageal manometry, and 24-hour pH-metry were performed. We analyzed the duration of disease, allergies, blood peripheral eosinophilia, prevalence of dysphagia, number of food impaction episodes, and complications during the endoscopic procedure.


RESULTS
Eleven male patients with a mean age of 35 years were followed. Endoscopy showed esophageal disorders in all cases: 5 esophageal felinizations, mucosal abnormalities in 4 cases, distal rings in 3 cases, and 2 esophageal stenoses. In two cases mucosal tearing during the endoscopic procedure was described. In 6 patients the manometric study showed motor disorders affecting the esophageal body, 5 of them displaying hypomotility. Two patients showed pathological gastroesophageal reflux during pH-monitoring. Blood peripheral eosinophilia was detected in 3 patients.


CONCLUSIONS
Although endoscopic abnormalities are frequently found, they do not usually explain dysphagia and food impaction episodes in EE. Ineffective esophageal peristalsis is the most prevalent manometric disorder associated with this entity, although it is not clearly related to symptom worsening either.
Martín Martín
L
L
Servicio de Hepatogastroenterología, Hospital Universitario de La Princesa, Universidad Autónoma de Madrid. lmleticia@yahoo.es
Santander Vaquero
C
C
Sánchez Prudencio
S
S
Cantero Perona
J
J
Gisbert
J P
JP
Moreno-Otero
R
R
D000328:Adult; D004802:Eosinophilia / Q000175:diagnosis* / Q000503:physiopathology*; D004941:Esophagitis / Q000175:diagnosis* / Q000503:physiopathology*; D004945:Esophagoscopy; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008365:Manometry; D008875:Middle Aged; D011446:Prospective Studies; D055815:Young Adult