A multi-type branching model with varying environment for bacterial dynamics with postantibiotic effect.
A multi-type branching process with varying environment was used to construct a pharmacokinetic/pharmacodynamic (PK/PD) model that captures the postantibiotic effect (PAE) seen in bacterial populations after exposure of antibiotics. This phenomenon of continued inhibition of bacterial growth even after removal of the antibiotic from the growth medium is of high relevance in the context of optimizing dosing regimens. The clinical implication of long PAEs lies in the interesting possibility of increasing the intervals between drug administrations. The model structure is generalizable to most types of antibiotics and is useful both as a theoretical framework for understanding the time properties of PAE and to explore optimal antibiotic dosing regimens. Data from an in vitro study with Escherichia coli exposed to different dosing regimens of cefotaxime were used to evaluate the model.
Geli
Patricia
P
Department of Mathematics, Stockholm University, Stockholm, Sweden. patricia@math.su.se
Andersson
Mikael
M
Svensson
Ake
A
Andersson
Dan I
DI
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development*; D001432:Bacteriology; D002439:Cefotaxime / Q000494:pharmacology; D003198:Computer Simulation; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D008954:Models, Biological
D000900:Anti-Bacterial Agents; D002439:Cefotaxime