Synthesis of 6-O-methotrexylhyaluronan as a drug delivery system.
Selective halogenation of hyaluronan and partial halogen substitution by methotrexate led to 6-chloro-6-deoxy-6-O-methotrexylhyaluronan, a potential antitumor drug. The remaining halogen could be further substituted by a second organic carboxylate, leading to mixed esters. 6-O-Acetyl-6-O-methotrexylhyaluronan and 6-O-butyryl-6-O-methotrexylhyaluronan were thus synthesized and characterized by NMR spectroscopy.
Sorbi
Claudia
C
Eurand S.p.A., Area Science Park, Padriciano 99, 34012 Trieste, Italy.
Bergamin
Massimo
M
Bosi
Susanna
S
Dinon
Francesca
F
Aroulmoji
Vincent
V
Khan
Riaz
R
Murano
Erminio
E
Norbedo
Stefano
S
D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry*; D006820:Hyaluronic Acid / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008727:Methotrexate / Q000737:chemistry*; D015394:Molecular Structure
D004337:Drug Carriers; D006820:Hyaluronic Acid; D008727:Methotrexate