title: [Alzheimer vaccine].
abstract: Autopsy cases who had received Abeta vaccine showed clearance of senile plaques, and beneficial effect was shown in patients who had high antibody titers to amyloid plaques. Thus, vaccination is widely accepted as promising therapy for Alzheimer disease. Since active immunization induced autoimmune-like meningoencephalitis, pharmaceutical companies are interested in passive immunization using monoclonal antibodies to Abeta. However, due to immunization burden and economical issues, safe active immunization is still attractive. We developed oral or nasal Abeta vaccine using viral vectors and Abeta cDNA with a signal peptide. These vaccine reduced amyloid burden and improved cognitive functions in mice. We believe this vaccine is useful for prevention and treatment of Alzheimer disease.
authors.affiliation: National Institute for Longevity Sciences, NCGG.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tabira
mesh_terms: D000281:Administration, Intranasal; D000284:Administration, Oral; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000517:prevention & control*; D023582:Alzheimer Vaccines / Q000008:administration & dosage; D016229:Amyloid beta-Peptides / Q000235:genetics / Q000276:immunology; D000911:Antibodies, Monoclonal / Q000276:immunology; D018076:DNA, Complementary; D000229:Dependovirus; D015195:Drug Design; D005822:Genetic Vectors; D000068717:Glatiramer Acetate; D006801:Humans; D007116:Immunization, Passive; D010455:Peptides
chemical_list: C437846:AN-1792; D023582:Alzheimer Vaccines; D016229:Amyloid beta-Peptides; D000911:Antibodies, Monoclonal; D018076:DNA, Complementary; D010455:Peptides; D000068717:Glatiramer Acetate