Mitosis: new roles for myosin-X and actin at the spindle.
Roles for actin and myosin in positioning mitotic spindles in the cell are well established. A recent study of myosin-X function in early Xenopus embryo mitosis now reports that this unconventional myosin is required for pole integrity and normal spindle length by localizing to poles and exerting pulling forces on actin filaments within the spindle.
Wühr
Martin
M
Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Mitchison
Timothy J
TJ
Field
Christine M
CM
D000199:Actins / Q000502:physiology*; D000818:Animals; D004625:Embryo, Nonmammalian / Q000502:physiology; D008938:Mitosis; D009218:Myosins / Q000502:physiology*; D008941:Spindle Apparatus / Q000502:physiology*; D029867:Xenopus Proteins / Q000502:physiology*; D014982:Xenopus laevis
D000199:Actins; C492069:Myo10 protein, Xenopus; D029867:Xenopus Proteins; D009218:Myosins