title: Morphine-6-glucuronide induces contraction of the ileal circular muscle more potently than morphine in mice.
abstract: It has been reported that morphine-6-glucuronide inhibits small intestinal transit in mice more potently than morphine. In this study, we investigated the effects of morphine, morphine-6-glucuronide and morphine-3-glucuronide on the contractile response of the circular muscle isolated from mouse ileum. Morphine and morphine-6-glucuronide induced tonic contraction dose-dependently, and the contractile force of morphine-6-glucuronide was greater than that of morphine. Morphine-3-glucuronide induced slight contraction at high dose. These results suggest that the strong contraction induced by morphine-6-glucuronide contributed to the inhibition of small intestinal transit in mice.
authors.affiliation: Department of Molecular Pharmacology and Pharmacotherapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Inohana, Chiba, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Iwata
authors.forename: Shizuko
authors.initials: S
authors.lastname: Tsuchiya
authors.forename: Koichi
authors.initials: K
authors.lastname: Ueno
authors.forename: Tomonori
authors.initials: T
authors.lastname: Nakamura
authors.forename: Shingo
authors.initials: S
authors.lastname: Yano
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005772:Gastrointestinal Transit / Q000187:drug effects; D007082:Ileum / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology*; D009022:Morphine Derivatives / Q000008:administration & dosage / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects
chemical_list: D009022:Morphine Derivatives; C035349:morphine-6-glucuronide; D009020:Morphine; C018108:morphine-3-glucuronide