title: Insight into the role of HOG pathway components Ssk2p, Pbs2p, and Hog1p in the opportunistic yeast Candida lusitaniae.
abstract: In the present study, we have investigated the role of SSK2, PBS2, and HOG1, encoding modules of the high-osmolarity-glycerol mitogen-activated protein kinase pathway in Candida lusitaniae. Functional analysis of mutants indicated that Ssk2p, Pbs2p, and Hog1p are involved in osmotolerance, drug sensitivity, and heavy metal tolerance but not in oxidant stress adaptation.
authors.affiliation: Programme Chimiorésistance des Levures Pathogènes, EA209 Eucaryotes Pathogènes: Transports Membranaires et Chimiorésistance, UFR des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, 75006 Paris, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Boisnard
authors.forename: Gwenaël
authors.initials: G
authors.lastname: Ruprich-Robert
authors.forename: Martine
authors.initials: M
authors.lastname: Florent
authors.forename: Bruno
authors.initials: B
authors.lastname: Da Silva
authors.forename: Florence
authors.initials: F
authors.lastname: Chapeland-Leclerc
authors.forename: Nicolas
authors.initials: N
authors.lastname: Papon
mesh_terms: D002175:Candida / Q000201:enzymology* / Q000235:genetics / Q000502:physiology; D002177:Candidiasis / Q000382:microbiology*; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism*; D005990:Glycerol / Q000378:metabolism*; D006801:Humans; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism*; D009994:Osmolar Concentration; D015398:Signal Transduction
chemical_list: D005656:Fungal Proteins; D020928:Mitogen-Activated Protein Kinases; D005990:Glycerol