title: The epsin 4 gene is associated with psychotic disorders in families of Latin American origin.
abstract: This study attempted to replicate evidence for association of the Epsin 4 gene (which encodes enthoprotin, a protein involved in vesicular transport) to schizophrenia in a new sample of families segregating schizophrenia drawn from the Latin American population. 1,423 subjects (767 with a history of psychosis) from 337 Latino families were genotyped using three single nucleotide polymorphisms (SNPs) spanning the Epsin 4 gene. A family based association test was utilized to test for association of these SNPs to the phenotypes of psychosis and schizophrenia. Haplotypes defined by these three SNPs showed significant association to the phenotype of psychosis in this sample (global p value=0.014, bi-allelic p value=0.047). Variation in the Epsin 4 gene is significantly associated with psychotic disorder in this Latino population. This provides additional support for the involvement of enthoprotin in the pathogenesis of schizophrenia and other psychotic disorders.
authors.affiliation: Psychiatric Genetics Research Center, Department of Psychiatry, University of Texas Health Science Center at San Antonio, TX 78229-3900, USA. escamillam@uthscsa.edu
authors.forename: Michael
authors.initials: M
authors.lastname: Escamilla
authors.forename: Byung Dae
authors.initials: BD
authors.lastname: Lee
authors.forename: Alfonso
authors.initials: A
authors.lastname: Ontiveros
authors.forename: Henriette
authors.initials: H
authors.lastname: Raventos
authors.forename: Humberto
authors.initials: H
authors.lastname: Nicolini
authors.forename: Ricardo
authors.initials: R
authors.lastname: Mendoza
authors.forename: Alvaro
authors.initials: A
authors.lastname: Jerez
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Munoz
authors.forename: Rolando
authors.initials: R
authors.lastname: Medina
authors.forename: Andres
authors.initials: A
authors.lastname: Figueroa
authors.forename: Consuelo
authors.initials: C
authors.lastname: Walss-Bass
authors.forename: Regina
authors.initials: R
authors.lastname: Armas
authors.forename: Salvador
authors.initials: S
authors.lastname: Contreras
authors.forename: Mercedes E
authors.initials: ME
authors.lastname: Ramirez
authors.forename: Albana
authors.initials: A
authors.lastname: Dassori
mesh_terms: D033942:Adaptor Proteins, Vesicular Transport / Q000235:genetics*; D002489:Central America / Q000208:ethnology; D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D005190:Family; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D005838:Genotype; D006239:Haplotypes; D006630:Hispanic or Latino / Q000235:genetics*; D006801:Humans; D008800:Mexico / Q000208:ethnology; D010375:Pedigree; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011618:Psychotic Disorders / Q000235:genetics* / Q000503:physiopathology; D012559:Schizophrenia / Q000235:genetics / Q000503:physiopathology
chemical_list: D033942:Adaptor Proteins, Vesicular Transport; C475910:CLINT1 protein, human