Advances in protein therapeutics.
This review summarizes recent advances in the discovery and development of novel protein therapeutics. The most advanced technology platforms currently available are highlighted and examples where novel protein scaffolds have been successfully applied to identify clinical candidates are provided. This review also examines the progress of these molecules in the clinic and discusses the advantages and disadvantages of these approaches over traditional methods.
Woodnutt
Gary
G
CovX Research, 9381 Judicial Drive, San Diego, CA 92121, USA. gwoodnutt@covx.com
Violand
Bernard
B
North
Michael
M
D000818:Animals; D000906:Antibodies / Q000008:administration & dosage; D019677:Artificial Gene Fusion; D004337:Drug Carriers; D055808:Drug Discovery; D006801:Humans; D011506:Proteins / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*
D000906:Antibodies; D004337:Drug Carriers; D011506:Proteins