title: Cerebral sinus venous thrombosis in a subject with thyrotoxicosis and MTHFR gene polymorphism.
abstract: We report a case of cerebral venous thrombosis (CVT) due to tyrotoxicosis in a patient with methylenetetrahydro-folate-reductase (MTHFR) gene polymorphism C677T, (genotype 677TT), in which discontinuation of intravenous heparin was followed by clinical and radiological worsening despite warfarin treatment. We discuss the relationship between CVT, MTHFR hyperthiroidism and anticoagulant therapy.
authors.affiliation: Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Via De Toni 5, Genoa, Italy. mdelsette@neurologia.unige.it
authors.forename: Laura
authors.initials: L
authors.lastname: Strada
authors.forename: Carlo
authors.initials: C
authors.lastname: Gandolfo
authors.forename: Massimo
authors.initials: M
authors.lastname: Del Sette
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D011110:Polymorphism, Genetic; D012851:Sinus Thrombosis, Intracranial / Q000188:drug therapy / Q000209:etiology* / Q000235:genetics*; D013971:Thyrotoxicosis / Q000150:complications* / Q000235:genetics; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D014859:Warfarin; D006493:Heparin; D042965:Methylenetetrahydrofolate Reductase (NADPH2)