title: Alcohol use and fasting glucose in a developing southern Chinese population: the Guangzhou Biobank Cohort Study.
abstract: BACKGROUND
  In observational studies, mainly from Western Caucasian populations, moderate alcohol use has been shown to be associated with a lower risk of diabetes. However, whether the protection is due to the attributes of alcohol or to those of moderate alcohol users is difficult to disentangle. A population with a different distribution of alcohol consumption and diabetes prevalence from Western populations was studied as a counterfactual comparison.
  
  
  METHODS
  Baseline data from the Guangzhou Biobank Cohort Study phases 1 and 2 (2003-6) were used to examine the adjusted associations, using multivariable censored linear regression, of alcohol use with fasting blood glucose in older (> or =50 years) men (n = 5740) and women (n = 14 274) from southern China. Moderate alcohol use was defined as weekly drinking of < or =210 g alcohol in men and < or =140 g in women. The expected associations of alcohol with high-density lipoprotein (HDL) cholesterol and blood pressure were also checked.
  
  
  RESULTS
  Moderate alcohol users had very similar fasting glucose levels to never users, adjusted for age, sex, socioeconomic status, smoking and physical activity. In contrast, moderate alcohol users had higher HDL-cholesterol by 0.05 mmol/litre (95% CI 0.02 to 0.07). Excessive (more than moderate) alcohol users had higher fasting glucose.
  
  
  CONCLUSIONS
  In an understudied population with a different pattern of alcohol use from the populations usually studied, the biologically expected effects of moderate alcohol use were seen, but there was little effect on fasting glucose. Although cross-sectional studies cannot be conclusive, this pattern of findings, if confirmed, suggests that moderate alcohol use may not affect fasting glucose, although excessive use may be a risk factor.
authors.affiliation: School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
authors.forename: C M
authors.initials: CM
authors.lastname: Schooling
authors.forename: C Q
authors.initials: CQ
authors.lastname: Jiang
authors.forename: T H
authors.initials: TH
authors.lastname: Lam
authors.forename: W S
authors.initials: WS
authors.lastname: Zhang
authors.forename: K K
authors.initials: KK
authors.lastname: Cheng
authors.forename: G M
authors.initials: GM
authors.lastname: Leung
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000097:blood* / Q000453:epidemiology; D001786:Blood Glucose / Q000378:metabolism*; D002681:China / Q000453:epidemiology; D008076:Cholesterol, HDL / Q000097:blood; D004812:Epidemiologic Methods; D000431:Ethanol / Q000008:administration & dosage; D005215:Fasting / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012923:Social Class
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D000431:Ethanol