Efficacy of antimicrobial activity of slow release silver nanoparticles dressing in post-cardiac surgery mediastinitis.
We report our preliminary experience in post-cardiac surgery mediastinitis using a recently introduced silver-releasing dressing claiming prompt antibacterial activity. Acticoat, a silver nanoparticles slow release dressing was used in four patients with documented post-cardiac surgery mediastinitis and persistently positive microbiological cultures despite vacuum-assisted closure (VAC) therapy. In all four patients negative cultures were obtained within a maximum of 72 h and patients were discharged within a maximum of 20 days.
Totaro
Pasquale
P
Cardiac Surgery, Civic Hospital, Brescia, Italy. ptotaro@yahoo.com
Rambaldini
Manfredo
M
D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001458:Bandages; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D003131:Combined Modality Therapy; D003646:Debridement; D005260:Female; D006801:Humans; D007902:Length of Stay; D008297:Male; D008480:Mediastinitis / Q000382:microbiology / Q000628:therapy*; D008875:Middle Aged; D053758:Nanoparticles; D054843:Negative-Pressure Wound Therapy; D010865:Pilot Projects; D011091:Polyesters / Q000627:therapeutic use*; D011095:Polyethylenes / Q000627:therapeutic use*; D012834:Silver / Q000627:therapeutic use*; D013249:Sternum / Q000601:surgery; D013530:Surgical Wound Infection / Q000382:microbiology / Q000628:therapy*; D016896:Treatment Outcome
C117408:Acticoat; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D011091:Polyesters; D011095:Polyethylenes; D012834:Silver