title: Beneficial effects of curcumin on hyperlipidemia and insulin resistance in high-fat-fed hamsters.
abstract: This study investigated the effect of curcumin (0.05-g/100-g diet) supplementation on a high-fat diet (10% coconut oil, 0.2% cholesterol, wt/wt) fed to hamsters, one of the rodent species that are most closely related to humans in lipid metabolism. Curcumin significantly lowered the levels of free fatty acid, total cholesterol, triglyceride, and leptin and the homeostasis model assessment of insulin resistance index, whereas it elevated the levels of high-density lipoprotein cholesterol and apolipoprotein (apo) A-I and paraoxonase activity in plasma, compared with the control group. The levels of hepatic cholesterol and triglyceride were also lower in the curcumin group than in the control group. In the liver, fatty acid beta-oxidation activity was significantly higher in the curcumin group than in the control group, whereas fatty acid synthase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and acyl coenzyme A:cholesterol acyltransferase activities were significantly lower. Curcumin significantly lowered the lipid peroxide levels in the erythrocyte and liver compared with the control group. These results indicate that curcumin exhibits an obvious hypolipidemic effect by increasing plasma paraoxonase activity, ratios of high-density lipoprotein cholesterol to total cholesterol and of apo A-I to apo B, and hepatic fatty acid oxidation activity with simultaneous inhibition of hepatic fatty acid and cholesterol biosynthesis in high-fat-fed hamsters.
authors.affiliation: Department of Nutrition Education, Graduate School of Education, Sunchon National University, Jeonnam 540-742, South Korea.
authors.forename: Eun-Mi
authors.initials: EM
authors.lastname: Jang
authors.forename: Myung-Sook
authors.initials: MS
authors.lastname: Choi
authors.forename: Un Ju
authors.initials: UJ
authors.lastname: Jung
authors.forename: Myung-Joo
authors.initials: MJ
authors.lastname: Kim
authors.forename: Hye-Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Seon-Min
authors.initials: SM
authors.lastname: Jeon
authors.forename: Su-Kyung
authors.initials: SK
authors.lastname: Shin
authors.forename: Chi-Nam
authors.initials: CN
authors.lastname: Seong
authors.forename: Mi-Kyung
authors.initials: MK
authors.lastname: Lee
mesh_terms: D000818:Animals; D016632:Apolipoprotein A-I / Q000097:blood; D043303:Aryldialkylphosphatase / Q000097:blood; D002318:Cardiovascular Diseases / Q000209:etiology; D008076:Cholesterol, HDL / Q000097:blood; D006224:Cricetinae; D003474:Curcumin / Q000494:pharmacology*; D004041:Dietary Fats / Q000008:administration & dosage; D005227:Fatty Acids / Q000096:biosynthesis; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood; D015227:Lipid Peroxidation; D008297:Male; D008647:Mesocricetus
chemical_list: D016632:Apolipoprotein A-I; D008076:Cholesterol, HDL; D004041:Dietary Fats; D005227:Fatty Acids; D000960:Hypolipidemic Agents; D020738:Leptin; D043303:Aryldialkylphosphatase; D003474:Curcumin