title: Protothecosis as a cause of chronic diarrhoea in a dog.
abstract: The clinical form of the protothecosis in animals is most commonly observed in countries with a warm and moist climate, only a few reports describing cases of this infection in cooler areas of the word exist. In the case of large bowel infection in dogs, organisms colonise the lamina propria and submucosa causing severe necrotizing ulcerative or haemorrhagic enterocolitis. In this report the intestinal form of protothecosis in 1.5-year-old, male, mongrel dog with chronic hemorrhagic diarrhoea is described. History revealed that the dog spent some time in the countryside and afterwards diarrhoea with fresh blood appeared. The results of morphological and biochemical blood analysis were normal and stool examination did not reveal the presence of parasites. Treatment with anti-inflammatory doses of prednisone, metronidazole and enrofloxacin followed by sulphasalazine resulted in a short period of improvement, but was followed by deep deterioration of animal status. Because of the relapse diagnostic laparotomy was performed and tissue samples of the colon and jejunum were obtained for histopathology. On the basis of the clinical signs, exploratory laparotomy findings and histopathology the diagnosis of canine intestinal prototecosis was made and medical treatment was recommended.
authors.affiliation: Department of Clinical Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences (WULS), Nowoursynowska 159c, 02-766 Warsaw, Poland. rafal-sapierzynski@sggw.pl
authors.forename: R
authors.initials: R
authors.lastname: Sapierzyński
authors.forename: O
authors.initials: O
authors.lastname: Jaworska
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use; D003106:Colon / Q000382:microbiology / Q000473:pathology; D003967:Diarrhea / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D004283:Dog Diseases / Q000382:microbiology / Q000473:pathology; D004285:Dogs; D017809:Fatal Outcome; D007239:Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D007583:Jejunum / Q000382:microbiology / Q000473:pathology; D007654:Ketoconazole / Q000627:therapeutic use; D008297:Male; D011525:Prototheca; D012293:Rifampin / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D007654:Ketoconazole; D012293:Rifampin