title: [Effect of dynamic hyperinflation on exertional dyspnea, exercise performance and quality of life in COPD].
abstract: There is increasing evidence that dynamic hyperinflation (DH) have negative effects on exercise performance and quality of life in chronic obstructive pulmonary disease (COPD) patients. The aim of this study was to investigate effect of dynamic hyperinflation on exertional dyspnea, exercise performance and quality of life in patients with COPD. 72 clinically stable patients with moderate to severe COPD and 30 healthy age-matched control subjects were included in this study. Pulmonary function tests including lung volumes and maximal respiratory muscle forces, arterial blood gas analyses, evaluation of exertional dyspnea with the Borg scale, and The Saint George Respiratory Questionnaire (SGRQ, Turkish version) were performed at rest and after a 6-min walk test. We measured the change in inspiratory capacity (AlphaIC) after exercise to reflect DH. 80% of patients with COPD significantly decreased IC after exercise (DH). AlphaIC were -0.27 +/- 0.26 L in COPD and 0.8 +/- 0.17 L in controls (p= 0.001). A stepwise multiple regression analysis showed that to be a patient with COPD, Basal Dyspnea Index (BDI) and AlphaIC were the best predictors of 6 MWD (r(2)= 0.53, p< 0.001). FEV1 added an additinal 9% to the variance in 6 MWD. Exertional dyspnea (AlphaBorg) correlated with AlphaIC (r= -0.44, p= 0.0001) and BDI (r= 0.34, p= 0.02). AlphaIC significantly correlated with symptom (r= -0.36, p= 0.008), activity (r= -0.31, p= 0.03) and total scores (r= -0.30, p= 0.04) of SGRQ. Dynamic hyperinflation can often occur during exersice in patients with COPD. Extent of dynamic hyperinflation could able to explain exercise capacity limitation, exercise dyspnea, and poor quality of life in patients with COPD.
authors.affiliation: Department of Chest Diseases, Faculty of Medicine, Mersin University, Içel, Turkey.
authors.forename: Eylem Sercan
authors.initials: ES
authors.lastname: Ozgur
authors.forename: Sibel
authors.initials: S
authors.lastname: Atis
authors.forename: Arzu
authors.initials: A
authors.lastname: Kanik
mesh_terms: D001784:Blood Gas Analysis; D016022:Case-Control Studies; D004417:Dyspnea / Q000209:etiology*; D005080:Exercise Test / Q000379:methods; D017079:Exercise Tolerance; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007320:Inspiratory Capacity; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion / Q000502:physiology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology* / Q000523:psychology*; D011788:Quality of Life; D012129:Respiratory Function Tests; D013147:Spirometry / Q000379:methods / Q000592:standards; D011795:Surveys and Questionnaires; D014797:Vital Capacity; D016138:Walking