title: [Extended hepatic pedicle occlusion in major hepatectomy for primary liver cancer].
abstract: OBJECTIVE
  To evaluate the influence of extended hepatic pedicle occlusion (HPO) on hepatic ischemic/reperfusion (I/R) injury and intraoperative blood loss in major hepatectomy for primary liver cancer (PLC).
  
  
  METHODS
  Between June 2001 and December 2005, a total number of 843 patients with PLC had been operated on. Those whose hepatic pedicle were occluded continuously for or longer than 30 min during hepatectomy were retrospectively reviewed (continuous HPO group) and compared to the patients whose hepatic pedicle were occluded for the same length of time but intermittently (intermittent HPO group). The amount of intraoperative blood loss, the percentage of the patients who needed blood transfusion and postoperative liver biochemical tests were compared between the two groups.
  
  
  RESULTS
  There were 35 cases in continuous HPO group and 38 cases in intermittent HPO group with occlusion time between 30 min and 45 min. The two groups were matched for underlying liver disease ,preoperative liver function, tumor size and location, major intrahepatic vessel involvements and the types and extensions of the hepatectomies. The mean intraoperative blood loss in continuous HPO group was significantly less than that in intermittent HPO group (660 ml vs. 1054 ml, P < 0.05); accordingly, the percentage of patients who need blood transfusion in continuous HPO group was significantly lower than that in intermittent HPO group (48.6% vs. 78.9%, P < 0.01). Patients in both of the groups were recovered smoothly after operation, with no occurrence of liver failure.
  
  
  CONCLUSIONS
  The hepatic pedicle can be continuously occluded for 3045 min in cirrhotic patients with well compensated liver function, and when compared to routine intermittent HPO, continuous HPO significantly decreases the intraoperative blood loss and reduces the need for transfusion. Meanwhile it does not increase the hepatic I/R injury.
authors.affiliation: Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai 200438, China. wangyi-ehbh@163.com
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Ke-Ji
authors.initials: KJ
authors.lastname: Chen
authors.forename: You-Lei
authors.initials: YL
authors.lastname: Zhang
authors.forename: Yan-Fu
authors.initials: YF
authors.lastname: Sun
authors.forename: Gong-Tian
authors.initials: GT
authors.lastname: Wei
authors.forename: Lei
authors.initials: L
authors.lastname: Hu
mesh_terms: D000328:Adult; D000368:Aged; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D005260:Female; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000503:physiopathology; D008113:Liver Neoplasms / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies