title: [Pathophysiological mechanisms of hemorrhagic stroke and the ways of differential therapy].
abstract: The changes developing in the perifocal area of hematoma and perspectives of antioxidant and chelate therapy were studied on the model of experimental hemorrhagic stroke and in clinical conditions. Microcirculatory, ischemic and inflammation disturbances with a certain time sequence were found in the perifocal areas. These changes, along with hypostasis and oxidative stress, form the pathobiochemical cascade of changes in hemorrhagic stroke and are potential therapeutic targets. Administering of an antioxidant and chelate drug histochrome reduces the intensity of changes in the perifocal area in the experimental conditions. In clinical conditions, it accelerates the dynamics of brain and meningeal symptoms regression and improves the blood rheological properties.
authors.forename: E I
authors.initials: EI
authors.lastname: Gusev
authors.forename: V A
authors.initials: VA
authors.lastname: Stonik
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Martynov
authors.forename: M R
authors.initials: MR
authors.lastname: Guseva
authors.forename: I A
authors.initials: IA
authors.lastname: Shchukin
authors.forename: I V
authors.initials: IV
authors.lastname: Diuĭzen
authors.forename: E V
authors.initials: EV
authors.lastname: Koplik
authors.forename: N P
authors.initials: NP
authors.lastname: Mishchenko
authors.forename: I G
authors.initials: IG
authors.lastname: Agafonova
authors.forename: T I
authors.initials: TI
authors.lastname: Kolesnikova
authors.forename: S A
authors.initials: SA
authors.lastname: Fedoreev
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002545:Brain Ischemia / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D002543:Cerebral Hemorrhage / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D002614:Chelating Agents / Q000627:therapeutic use*; D008297:Male; D009285:Naphthoquinones / Q000627:therapeutic use*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D002614:Chelating Agents; D009285:Naphthoquinones; D010975:Platelet Aggregation Inhibitors; C103614:histochrome