title: Probing pathways periodically.
abstract: Signal transduction pathways are used by cells to process and transmit information about their external surroundings. These systems are dynamic, interconnected molecular networks. Therefore, full characterization of their behavior requires a systems-level analysis. Investigations with temporally oscillating input signals probed the dynamic properties of the high-osmolarity glycerol (HOG) pathway of the budding yeast Saccharomyces cerevisiae. These studies shed light on how the network functions as a whole to respond to changing environmental conditions.
authors.affiliation: Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA. telston@med.unc.edu
authors.forename: Timothy C
authors.initials: TC
authors.lastname: Elston
mesh_terms: D000818:Animals; D005990:Glycerol / Q000494:pharmacology; D006801:Humans; D008954:Models, Biological; D009995:Osmosis / Q000187:drug effects / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000502:physiology*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*
chemical_list: D005990:Glycerol