title: Pyoderma gangrenosum following isotretinoin therapy for acne nodulocystic.
abstract: A 19-year-old man with nodulocystic acne on baseline was treated with isotretinoin therapy. After 1 month on the medication, he developed pyoderma gangrenosum on his pubis area, arms and legs, and pathergy on a puncture site. Possible underlying diseases were excluded. The patient was started on steroids (prednisone 1 mg/kg/d) and isotretinoin therapy was withdrawn. Later the prednisone was tapered and dapsone 100 mg/daily was initiated. After 10 months of follow-up all lesions had healed and no underlying diseases developed.
authors.affiliation: Department of Dermatology, Instituto de Dermatologia Prof Rubem David Azulay, Rio de Janeiro, Brazil. mpaulatinoco@gmail.com
authors.forename: Maria Paula
authors.initials: MP
authors.lastname: Tinoco
authors.forename: Carla
authors.initials: C
authors.lastname: Tamler
authors.forename: Gustavo
authors.initials: G
authors.lastname: Maciel
authors.forename: Deborah
authors.initials: D
authors.lastname: Soares
authors.forename: João Carlos
authors.initials: JC
authors.lastname: Avelleira
authors.forename: David
authors.initials: D
authors.lastname: Azulay
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000473:pathology; D003622:Dapsone / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D017511:Pyoderma Gangrenosum / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D003622:Dapsone; D015474:Isotretinoin; D011241:Prednisone