Design of polymeric carriers for cancer-specific gene targeting: utilization of abnormal protein kinase Calpha activation in cancer cells.
We succeeded in cancer cell specific gene expression by using a polyplex responsive to protein kinase Calpha, which is activated in various types of cancer cells.
Kang
Jeong-Hun
JH
Department of Applied Chemistry, Faculty of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan. jrjhkangtcm@mbox.nc.kyushu-u.ac.jp
Asai
Daisuke
D
Kim
Jong-Hwan
JH
Mori
Takeshi
T
Toita
Riki
R
Tomiyama
Tetsuro
T
Asami
Yoji
Y
Oishi
Jun
J
Sato
Yuko T
YT
Niidome
Takuro
T
Jun
Byungdug
B
Nakashima
Hideki
H
Katayama
Yoshiki
Y
D000595:Amino Acid Sequence; D000818:Animals; D045744:Cell Line, Tumor; D054751:Cyclic AMP-Dependent Protein Kinase Catalytic Subunits / Q000378:metabolism*; D004247:DNA / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D004789:Enzyme Activation; D015972:Gene Expression Regulation, Neoplastic; D018390:Gene Targeting / Q000379:methods*; D018014:Gene Transfer Techniques; D006801:Humans; D008156:Luciferases / Q000096:biosynthesis / Q000235:genetics; D008546:Melanoma, Experimental / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D051379:Mice; D010455:Peptides / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D010766:Phosphorylation; D010957:Plasmids / Q000235:genetics; D013379:Substrate Specificity; D014162:Transfection
D010455:Peptides; D004247:DNA; D008156:Luciferases; D054751:Cyclic AMP-Dependent Protein Kinase Catalytic Subunits; C463959:protein kinase A Calpha