Recovery of viremic control after superinfection with pathogenic HIV type 1 in a long-term elite controller of HIV type 1 infection.
A human immunodeficiency virus type 1 (HIV-1)-infected elite controller (defined as an untreated HIV-1-infected person with a plasma HIV-1 RNA level <50 copies/mL for at least 12 months) who experienced a viremic episode after superinfection regained natural viremic control, although the viral loads in the patient's 2 partners, infected with the same viral strain, were continuously approximately 30-fold higher. Thus, host mechanisms seem to be able to repeatedly control HIV-1 replication, halting disease progression.
Rachinger
Andrea
A
Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, and Center for Infection and Immunity Amsterdam at the Academic Medical Center of the University of Amsterdam, The Netherlands.
Navis
Marjon
M
van Assen
Sander
S
Groeneveld
Paul H P
PH
Schuitemaker
Hanneke
H
D018791:CD4 Lymphocyte Count; D015658:HIV Infections / Q000276:immunology*; D020276:HIV Long-Term Survivors; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood; D015163:Superinfection / Q000276:immunology*; D019562:Viral Load; D014766:Viremia
D012367:RNA, Viral