title: The frequency, magnitude and timing of post-diagnosis body weight gain in Dutch breast cancer survivors.
abstract: To evaluate the association between systemic treatments and post-diagnosis weight gain in breast cancer patients during longer follow-up periods, we conducted a retrospective cohort study (n=271). Information on adjuvant systemic treatments and repeated body weight measurements was obtained from medical records, and analysed using multi-level regressions. During the first year, a mean weight change of +2.0kg (SD 4.9) was observed. Overall, 29% of all breast cancer patients had gained 5kg or more in body weight during total follow-up (median: 3 years). In multi-level analyses, women who received combined systemic treatment gained significantly more weight as compared with women who received no systemic treatment (4.5kg versus 2.0kg at 5 years post-diagnosis, p<0.05). Significant weight gain occurs in breast cancer patients in the Netherlands during the first year post-diagnosis. After the first year, further weight gain mainly occurs in women who receive chemotherapy in combination with endocrine therapy.
authors.affiliation: The Netherlands Cancer Institute, Division of Psychosocial Research and Epidemiology, Amsterdam, The Netherlands.
authors.forename: W H
authors.initials: WH
authors.lastname: Heideman
authors.forename: N S
authors.initials: NS
authors.lastname: Russell
authors.forename: C
authors.initials: C
authors.lastname: Gundy
authors.forename: M A
authors.initials: MA
authors.lastname: Rookus
authors.forename: D W
authors.initials: DW
authors.lastname: Voskuil
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000628:therapy*; D004965:Estrogen Antagonists / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D009426:Netherlands; D012189:Retrospective Studies; D017741:Survivors; D015430:Weight Gain
chemical_list: D004965:Estrogen Antagonists