title: Diastereoselective palladium-catalyzed alpha-arylation of 4-substituted cyclohexyl esters.
abstract: A diastereoselective palladium-catalyzed arylation of 4-substituted cyclohexyl esters has been developed. The reaction proceeds at room temperature in the presence of [(t-Bu3P)PdBr]2 providing products in up to 37:1 dr.
authors.affiliation: Chemical Process R&D, Amgen Inc, Thousand Oaks, California 91320, USA. ebercot@amgen.com
authors.forename: Eric A
authors.initials: EA
authors.lastname: Bercot
authors.forename: Seb
authors.initials: S
authors.lastname: Caille
authors.forename: Tracy M
authors.initials: TM
authors.lastname: Bostick
authors.forename: Krishnakumar
authors.initials: K
authors.lastname: Ranganathan
authors.forename: Randy
authors.initials: R
authors.lastname: Jensen
authors.forename: Margaret M
authors.initials: MM
authors.lastname: Faul