Cyclic neutropenia in mammals.
Cyclic neutropenia (CN) has been well documented in humans and the gray collie. A recent model of the architecture and dynamics of hematopoiesis has been used to provide insights into the mechanism of cycling of this disorder. It provides a link between the cycling period and the cells where the mutated ELA2 is expressed. Assuming that the biologic defect in CN is the same in dogs, and the observation that the structure of hematopoiesis is invariant across mammals, we use allometric scaling techniques to correctly predict the period of cycling in the gray collie and extend it to other mammals from mice to elephants. This work provides additional support for the relevance of animal models to understand disease but cautions that disease dynamics in model animals are different and this has to be taken into consideration when planning experiments.
Pacheco
Jorge M
JM
ATP-Group, CFTC and Departamento de Física da Faculdade de Ciências, Lisboa Codex, Portugal.
Traulsen
Arne
A
Antal
Tibor
T
Dingli
David
D
D000818:Animals; D049109:Cell Proliferation; D004195:Disease Models, Animal; D004285:Dogs; D006410:Hematopoiesis / Q000502:physiology; D006801:Humans; D008322:Mammals / Q000097:blood / Q000502:physiology*; D051379:Mice; D008954:Models, Biological; D009503:Neutropenia / Q000503:physiopathology / Q000662:veterinary*; D012697:Serine Endopeptidases / Q000235:genetics / Q000378:metabolism
D012697:Serine Endopeptidases; C117309:pancreatic elastase II