title: [Eccrine adenocarcinoma in a patient with familial breast carcinoma].
abstract: A 67-year-old patient developed a subcutaneous, non-tender nodule in her left groin over a period of about seven years. The patient underwent surgery and 4 procedures were required to obtain complete excision. The histopathologic findings showed eccrine adenocarcinoma, a member of the heterogeneous group of sweat gland tumors which occur primarily in adults with a peak of 50-60 years of age. Sweat gland carcinomas are extremely rare neoplasms of the skin and exhibit a slow growth rate with a rather high local recurrence rate. The tumor has a disposition to metastasize and shows a poor response rate to adjuvant therapy regimens. Therefore wide, deep surgical excision with an excision margin of 2-3 cm is the treatment of choice. Nevertheless there are some case reports on successful therapy of a metastasized sweat gland carcinoma with 5-fluorouracil and tamoxifen. Here further studies are needed to achieve a better survival rate for patients with metastatic disease.
authors.affiliation: Klinik für Allergologie und Dermatologie, Universitätsklinikum RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Deutschland. mwosnitza@ukaachen.de
authors.forename: M
authors.initials: M
authors.lastname: Wosnitza
authors.forename: A
authors.initials: A
authors.lastname: Rübben
authors.forename: N
authors.initials: N
authors.lastname: Pallua
authors.forename: M
authors.initials: M
authors.lastname: Megahed
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000556:secondary*; D000368:Aged; D000700:Analgesics / Q000627:therapeutic use; D004439:Eccrine Glands / Q000473:pathology*; D005260:Female; D006801:Humans; D013544:Sweat Gland Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics / Q000556:secondary*; D013629:Tamoxifen / Q000627:therapeutic use
chemical_list: D000700:Analgesics; D013629:Tamoxifen