title: Immunohistochemical expression of fatty acid synthase, Ki-67 and p53 in squamous cell carcinomas of the larynx.
abstract: Fatty acid synthase (FAS) is a recently discovered molecule involved in the energy supply to normal cells. FAS is overexpressed in neoplastic tissues because of their increased energy needs. We explored the immunohistochemical expression of FAS, Ki-67 and p53 in squamous cell carcinomas (SCC) of the larynx and their association with clinicopathological features and outcome. Specimens from 43 patients with SCC were evaluated. Statistical analysis revealed an association between poorly differentiated laryngeal carcinomas and FAS expression (p<0.005) and between FAS and Ki-67 overexpression (p<0.001). Finally, FAS expression was associated with overall survival (p<0.001). We suggest that FAS is a powerful prognostic indicator whose strength can be enhanced when it is evaluated together with clinicopathological data and Ki-67 expression.
authors.affiliation: Department of Otorhinolaryngology, La Sapienza University, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: De Vincentiis
authors.forename: P
authors.initials: P
authors.lastname: Di Cello
authors.forename: F
authors.initials: F
authors.lastname: Censi
authors.forename: M
authors.initials: M
authors.lastname: Leopizzi
authors.forename: S
authors.initials: S
authors.lastname: Natalizi
authors.forename: B
authors.initials: B
authors.lastname: Sardella
authors.forename: A
authors.initials: A
authors.lastname: Gallo
authors.forename: P
authors.initials: P
authors.lastname: Soldo
authors.forename: P L
authors.initials: PL
authors.lastname: Alò
authors.forename: G C
authors.initials: GC
authors.lastname: Zotti
authors.forename: C
authors.initials: C
authors.lastname: Della Rocca
authors.forename: D
authors.initials: D
authors.lastname: Pietrasanta
authors.forename: M
authors.initials: M
authors.lastname: Castelli
authors.forename: L
authors.initials: L
authors.lastname: Izzo
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D064429:Fatty Acid Synthases / Q000096:biosynthesis*; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D016158:Genes, p53; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods*; D019394:Ki-67 Antigen / Q000096:biosynthesis*; D007822:Laryngeal Neoplasms / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D019394:Ki-67 Antigen; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D064429:Fatty Acid Synthases