cis-Regulatory networks during development: a view of Drosophila.
Understanding how regulatory networks initiate, maintain and synchronise transcriptional states remains a fundamental goal of developmental biology. Complex patterns of spatio-temporal gene expression are generated through the combined inputs of signalling and transcriptional networks converging on cis-regulatory modules (CRMs). Detailed studies in Drosophila, using transgenic reporter assays and mutagenesis analysis, have dissected the regulatory logic of a number of CRMs. These data have recently been complemented by genome-wide maps of transcription factor binding, revealing an unprecedented view of CRM occupancy and network complexity. The synthesis of data for three well-characterised Drosophila developmental networks reveals emerging themes at both a CRM and a cis-regulatory network level.
Bonn
Stefan
S
European Molecular Biology Laboratory, Heidelberg, Germany.
Furlong
Eileen E M
EE
D000818:Animals; D004330:Drosophila / Q000235:genetics* / Q000254:growth & development; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D053263:Gene Regulatory Networks / Q000235:genetics*; D008957:Models, Genetic; D016296:Mutagenesis; D014157:Transcription Factors / Q000378:metabolism*
D014157:Transcription Factors