Alterations in the brain monoaminergic neurotransmitters of rainbow trout related to naphthalene exposure at the beginning of vitellogenesis.
The contents of dopamine (DA), noradrenaline (NA), serotonin (5HT), and some related metabolites were studied in different brain regions of rainbow trout at two different stages of sexual maturation (at the beginning of vitellogenesis), after naphthalene (NAP) administration. The effects of NAP varied according to duration of exposure, brain region and vitellogenesis stage of the trout, and were more significant during previtellogenesis. The changes observed in DA metabolism were generally stimulatory after exposure for 3 h, and either stimulatory or inhibitory (depending on the brain regions) after exposure for 3 days to NAP. NA levels were altered by NAP in various brain regions, but only during previtellogenesis. With respect to 5HT, treatment with NAP reduced levels of the amine and/or its main metabolite in most of the brain regions studied, particularly 3 h after treatment. The results suggest that NAP might interfere with the processes regulating brain monoamine metabolism, either locally or indirectly by altering steroid feedback to brain centres, and thus disrupt endocrine control of reproductive development through the brain-pituitary axis.
Gesto
Manuel
M
Laboratorio de Fisiología Animal, Departamento de Biología Funcional y CC de la Salud, Facultad de Biología, Universidad de Vigo, Vigo, 36310, Spain. manuelgesto@uvigo.es
Tintos
Adrián
A
Alvarez
Rosa
R
Soengas
José L
JL
Míguez
Jesús M
JM
D000704:Analysis of Variance; D000818:Animals; D001921:Brain / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D009281:Naphthalenes / Q000008:administration & dosage / Q000633:toxicity*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D017686:Oncorhynchus mykiss / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism; D014818:Vitellogenesis / Q000187:drug effects*
D009281:Naphthalenes; D018377:Neurotransmitter Agents; C031721:naphthalene; D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine