title: Effects of maintained weight loss on sleep dynamics and neck morphology in severely obese adults.
abstract: The goals of the study were to determine if moderate weight loss in severely obese adults resulted in (i) reduction in apnea/hypopnea index (AHI), (ii) improved pharyngeal patency, (iii) reduced total body oxygen consumption (VO(2)) and carbon dioxide production (VCO(2)) during sleep, and (iv) improved sleep quality. The main outcome was the change in AHI from before to after weight loss. Fourteen severely obese (BMI > 40 kg/m(2)) patients (3 males, 11 females) completed a highly controlled weight reduction program which included 3 months of weight loss and 3 months of weight maintenance. At baseline and postweight loss, patients underwent pulmonary function testing, polysomnography, and magnetic resonance imaging (MRI) to assess neck morphology. Weight decreased from 134 +/-6.6 kg to 118 +/- 6.1 kg (mean +/- s.e.m.; F = 113.763, P < 0.0001). There was a significant reduction in the AHI between baseline and postweight loss (subject, F = 11.11, P = 0.007). Moreover, patients with worse sleep-disordered breathing (SDB) at baseline had the greatest improvements in AHI (group, F = 9.00, P = 0.005). Reductions in VO(2) (285 +/- 12 to 234 +/-16 ml/min; F = 24.85, P < 0.0001) and VCO(2) (231 +/- 9 to 186 +/- 12 ml/min; F = 27.74, P < 0.0001) were also observed, and pulmonary function testing showed improvements in spirometry parameters. Sleep studies revealed improved minimum oxygen saturation (minSaO(2)) (83.4 +/- 61.9% to 89.1 +/- 1.2%; F = 7.59, P = 0.016), and mean SaO(2) (90.4 +/- 1.1% to 93.8 +/- 1.0%; F = 6.89, P = 0.022), and a significant increase in the number of arousals (8.1 +/- 1.4 at baseline, to 17.1 +/- 3.0 after weight loss; F = 18.13, P = 0.001). In severely obese patients, even moderate weight loss (approximately 10%) boasts substantial benefit in terms of the severity of SDB and sleep dynamics.
authors.affiliation: Division of Endocrinology, University of Colorado Denver, Aurora, Colorado, USA. teri.hernandez@uchsc.edu
authors.forename: Teri L
authors.initials: TL
authors.lastname: Hernandez
authors.forename: Robert D
authors.initials: RD
authors.lastname: Ballard
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Weil
authors.forename: Trudy Y
authors.initials: TY
authors.lastname: Shepard
authors.forename: Ann L
authors.initials: AL
authors.lastname: Scherzinger
authors.forename: Elizabeth R
authors.initials: ER
authors.lastname: Stamm
authors.forename: Teresa A
authors.initials: TA
authors.lastname: Sharp
authors.forename: Robert H
authors.initials: RH
authors.lastname: Eckel
mesh_terms: D000293:Adolescent; D000328:Adult; D002151:Calorimetry; D002245:Carbon Dioxide / Q000032:analysis; D002149:Energy Intake; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000503:physiopathology*; D010101:Oxygen Consumption; D010614:Pharynx / Q000502:physiology*; D012890:Sleep / Q000502:physiology*; D012891:Sleep Apnea Syndromes / Q000453:epidemiology; D015431:Weight Loss / Q000502:physiology*; D055815:Young Adult
chemical_list: D002245:Carbon Dioxide