title: CX3CL1/fractalkine regulates branching and migration of monocyte-derived cells in the mouse olfactory epithelium.
abstract: The olfactory epithelium (OE) is a site of massive adult neurogenesis where olfactory sensory neurons (OSNs) are continuously turned over. Tissue macrophages have been implicated in phagocytosis of degenerating cells but the molecular mechanisms that allow for their recruitment while maintaining a neurogenic microenvironment are poorly understood. This study reports that the neuroprotective chemokine CX3CL1 is expressed by OSNs and olfactory ensheathing cells. Monocyte-derived cells in the OE depend on CX3CL1-signalling for intraepithelial migration and apical dendrite expression. These observations are first to demonstrate phenotypic differences in appearance and distribution of monocyte-derived cells in nervous tissue due to CX3CR1 deficiency.
authors.affiliation: School of Anatomy and Human Biology, Faculty of Life and Physical Sciences, The University of Western Australia, Crawley, Australia. mruitenberg@anhb.uwa.edu.au
authors.forename: Marc J
authors.initials: MJ
authors.lastname: Ruitenberg
authors.forename: Jana
authors.initials: J
authors.lastname: Vukovic
authors.forename: Linda
authors.initials: L
authors.lastname: Blomster
authors.forename: Jarrad M
authors.initials: JM
authors.lastname: Hall
authors.forename: Steffen
authors.initials: S
authors.lastname: Jung
authors.forename: Luis
authors.initials: L
authors.lastname: Filgueira
authors.forename: Paul G
authors.initials: PG
authors.lastname: McMenamin
authors.forename: Giles W
authors.initials: GW
authors.lastname: Plant
mesh_terms: D000818:Animals; D000073883:CX3C Chemokine Receptor 1; D002452:Cell Count / Q000379:methods; D002465:Cell Movement / Q000235:genetics / Q000502:physiology*; D003712:Dendrites / Q000502:physiology*; D005260:Female; D049452:Green Fluorescent Proteins / Q000235:genetics; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008822:Mice, Transgenic; D009000:Monocytes / Q000502:physiology; D055495:Neurogenesis / Q000235:genetics*; D009831:Olfactory Mucosa / Q000166:cytology* / Q000378:metabolism; D018034:Olfactory Receptor Neurons / Q000166:cytology / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011916:Rats, Inbred F344; D019707:Receptors, Chemokine / Q000172:deficiency / Q000502:physiology*; D018121:Receptors, Cytokine / Q000235:genetics / Q000378:metabolism; D015728:Receptors, HIV / Q000235:genetics / Q000378:metabolism
chemical_list: D000073883:CX3C Chemokine Receptor 1; C471885:Cx3cr1 protein, mouse; D012333:RNA, Messenger; D019707:Receptors, Chemokine; D018121:Receptors, Cytokine; D015728:Receptors, HIV; D049452:Green Fluorescent Proteins