title: No ghrelin response to oral glucose in diabetes mellitus with gastroparesis.
abstract: To investigate the role of ghrelin, an endogenous ligand of the growth hormone secretagogue receptor, in diabetic gastroparesis, we evaluated the plasma ghrelin profile during the oral glucose tolerance test in 55 patients with diabetes (men/women: 36/19, mean +/- SE of age: 55.1 +/- 1.7 years) with or without gastroparesis (diagnosed by the (13)C-acetate breath test). We also further examined cardiac autonomic neuropathy by assessing 24-hour variation of the R-R interval in randomly selected 32 patients with diabetes (men/women: 23/9, mean +/- SE of age: 54.2 +/- 2.5 years), and evaluated the influence of autonomic neuropathy on ghrelin. The fasting plasma ghrelin level was significantly lower in diabetes mellitus with gastroparesis than in healthy controls (7.9 +/- 0.7 fmol/ml versus 16.6 +/- 5.3 fmol/ml, p = 0.006). Patients with diabetes with gastroparesis showed no decrease of plasma ghrelin after glucose loading, unlike patients without gastroparesis or healthy controls. Diabetes mellitus with autonomic neuropathy, but not those without it, also showed no decrease of plasma ghrelin after glucose loading. Diabetic gastroparesis may be related to ghrelin-associated neurohormonal abnormalities, but the pathophysiological meaning of this abnormal ghrelin response needs further clarification.
authors.affiliation: Department of Internal Medicine, Division of Metabolism and Endocrinology, St. Marianna University School of Medicine, Kawasaki, Japan.
authors.forename: Shiko
authors.initials: S
authors.lastname: Asai
authors.forename: Takuyuki
authors.initials: T
authors.lastname: Katabami
authors.forename: Naoko
authors.initials: N
authors.lastname: Obi
authors.forename: Tomoya
authors.initials: T
authors.lastname: Matsui
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kato
authors.forename: Ryusei
authors.initials: R
authors.lastname: Obi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Takehiro
authors.initials: T
authors.lastname: Kawata
authors.forename: Haruyuki
authors.initials: H
authors.lastname: Takama
authors.forename: Akio
authors.initials: A
authors.lastname: Ohta
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Tanaka
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001342:Autonomic Nervous System Diseases / Q000097:blood / Q000150:complications; D001786:Blood Glucose / Q000032:analysis; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications* / Q000378:metabolism; D003929:Diabetic Neuropathies / Q000097:blood / Q000378:metabolism; D015716:Electrocardiography, Ambulatory; D005260:Female; D018589:Gastroparesis / Q000097:blood / Q000150:complications* / Q000378:metabolism; D054439:Ghrelin / Q000097:blood* / Q000378:metabolism; D005947:Glucose / Q000008:administration & dosage*; D005951:Glucose Tolerance Test; D006331:Heart Diseases / Q000097:blood / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D054439:Ghrelin; D005947:Glucose