[What is new about endometriosis?].
Endometriosis concerns 6 to 10 % of the female population, and is responsible for severe pelvic pain and infertility. This estrogen dependant disease, is characterized by the presence of endometrial tissue outside of the uterus cavity. Although his physiopathology remains poorly understood, recent data have focused on angiogenesis, which could represent a key factor for the growing of lesions of endometriosis. New antiangiogenesis treatments represent a therapeutic hope, and have been tested in vitro or in vivo in mice. Those drugs have proven their efficacy on endometriotic lesions. Secondly, several hypothesis are discussed to explain infertility in endometriosis. In particular, a direct impact of peritoneal fluid from women with endometriosis on sperm DNA could be involved.
Dupas
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Hôpital Saint Antoine, service d'endocrinologie de la reproduction, 184 rue du Faubourg Saint Antoine 75012 Paris, France. claire.dupas@sat.aphp.fr
Christin-Maitre
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D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000818:Animals; D004195:Disease Models, Animal; D004715:Endometriosis / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology*; D004717:Endometrium / Q000098:blood supply; D005260:Female; D006801:Humans; D015994:Incidence; D007247:Infertility, Female / Q000209:etiology; D051379:Mice; D009389:Neovascularization, Pathologic / Q000517:prevention & control; D017699:Pelvic Pain / Q000209:etiology
D020533:Angiogenesis Inhibitors