title: Cystatin C or creatinine for detection of stage 3 chronic kidney disease in anorexia nervosa.
abstract: BACKGROUND
  Patients with anorexia nervosa (AN) are at a high risk of renal failure. Chronic kidney disease (CKD) is often missed in these patients because the serum creatinine is a poor marker of kidney function. We studied the utility of cystatin C to detect renal failure in this population.
  
  
  METHODS
  Twenty-seven AN patients were studied. Glomerular filtration rates (GFR) were measured with the chromium-51- ethylenediaminetetraacetate ((51)Cr-EDTA) method. We compared the ability of creatinine and cystatin C to detect stage 3 CKD (GFR below 60 ml/min) by ROC curve analysis.
  
  
  RESULTS
  In this cohort, there is no correlation between GFR and serum creatinine, but there is a significant correlation between cystatin C and GFR. By ROC analysis, the cystatin C concentration is better than the serum creatinine concentration for the detection of stage 3 CKD (area under the curve of 0.86 vs. 0.61, p = 0.05).
  
  
  CONCLUSIONS
  Plasma cystatin C is better than serum creatinine in detecting stage 3 CKD in patients with AN.
authors.affiliation: Department of Nephrology, University of Liège, Liège, Belgium. pierre_delanaye@yahoo.fr
authors.forename: Pierre
authors.initials: P
authors.lastname: Delanaye
authors.forename: Etienne
authors.initials: E
authors.lastname: Cavalier
authors.forename: Régis P
authors.initials: RP
authors.lastname: Radermecker
authors.forename: Nicolas
authors.initials: N
authors.lastname: Paquot
authors.forename: Gisèle
authors.initials: G
authors.lastname: Depas
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Chapelle
authors.forename: André J
authors.initials: AJ
authors.lastname: Scheen
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Krzesinski
mesh_terms: D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000097:blood* / Q000150:complications / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood*; D055316:Cystatin C / Q000097:blood*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D015415:Biomarkers; D055316:Cystatin C; D003404:Creatinine