Genotoxic effect of 2,4,6-trichlorophenol on p53 gene in zebrafish liver.
Trichlorophenol (2,4,6-trichlorophenol [TCP]), a probable human carcinogen, is widely present in the environment. Employing denaturing high-performance liquid chromatography and DNA sequencing analyses, we demonstrated that 10-d exposure of zebrafish to TCP at 5 microg/L resulted in elevated point mutations of p53 gene in the liver genome. The result suggests that TCP might be involved in carcinogenesis by inducing point mutations in the somatic genome.
Yin
Daqiang
D
School of Environment, State Key Laboratory of Pollution Control and Resource Reuse, Nanjing University, Nanjing, China.
Zhu
Hankai
H
Hu
Ping
P
Zhao
Qingshun
Q
D000818:Animals; D002733:Chlorophenols / Q000633:toxicity*; D008099:Liver / Q000187:drug effects*; D009153:Mutagens; D017354:Point Mutation / Q000187:drug effects; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*; D015027:Zebrafish
D002733:Chlorophenols; D009153:Mutagens; D016159:Tumor Suppressor Protein p53; C024564:2,4,6-trichlorophenol