title: Synthesis and antiviral activity of novel pyrazole derivatives containing oxime esters group.
abstract: Fourteen title compounds, 1-substituted-5-substitutedphenylthio-4-pyrazolaldoxime ester derivatives 4a-4n, were synthesized from the starting material 1-substitutedphenyl-3-methyl-5-substitutedphenylthio-4-pyrazolaldoximes 3 by treatment with acyl chloride. The synthesized compounds were characterized by physical constants, and the structures of the title compounds were further confirmed by IR, 1H NMR, 13C NMR and elemental analysis. The bioassay results showed that title compounds possessed weak to good anti-TMV bioactivity with 4l showing significant enhancement of disease resistance in tobacco leaves with high affinity for TMV CP.
authors.affiliation: Center for Research and Development of Fine Chemicals, Key Laboratory of Green Pesticide and Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, PR China.
authors.forename: Guiping
authors.initials: G
authors.lastname: Ouyang
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Chen
authors.forename: Xue-Jian
authors.initials: XJ
authors.lastname: Cai
authors.forename: Bao-An
authors.initials: BA
authors.lastname: Song
authors.forename: Pinaki S
authors.initials: PS
authors.lastname: Bhadury
authors.forename: Song
authors.initials: S
authors.lastname: Yang
authors.forename: Lin-Hong
authors.initials: LH
authors.lastname: Jin
authors.forename: Wei
authors.initials: W
authors.lastname: Xue
authors.forename: De-Yu
authors.initials: DY
authors.lastname: Hu
authors.forename: Song
authors.initials: S
authors.lastname: Zeng
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D010091:Oximes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000378:metabolism / Q000821:virology; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012313:RNA / Q000032:analysis / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014026:Nicotiana / Q000378:metabolism / Q000821:virology; D014027:Tobacco Mosaic Virus / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D004952:Esters; D010091:Oximes; D011720:Pyrazoles; D012313:RNA