Delayed substantia nigra damage and leukoencephalopathy after hypoxic-ischemic injury.
Delayed post-anoxic encephalopathy has rarely been reported, and has most commonly been associated with carbon monoxide poisoning. The underlying pathophysiological mechanism is unknown. We describe a patient with a delayed neurologic decline after a good initial recovery from a hypoxic-ischemic event precipitated by acute blood loss. MRI revealed early globus pallidus necrosis followed by delayed substantia nigra damage and leukoencephalopathy. We suggest that anemia might play a role in this pattern of hypoxic-ischemic brain injury.
Lou
Min
M
Department of neurology, The 2nd Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, 310009, China.
Jing
Chao-Hui
CH
Selim
Magdy H
MH
Caplan
Louis R
LR
Ding
Mei-Ping
MP
D000740:Anemia / Q000150:complications / Q000473:pathology; D015140:Dementia, Vascular / Q000150:complications / Q000473:pathology*; D005260:Female; D005917:Globus Pallidus / Q000473:pathology; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000150:complications / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009336:Necrosis; D013378:Substantia Nigra / Q000473:pathology*; D013997:Time Factors