Variations in serum müllerian inhibiting substance between white, black, and Hispanic women.
OBJECTIVE
To compare serum müllerian inhibiting substance (MIS) levels between white, black, and Hispanic women to determine whether ovarian aging occurs at a different time course for women of different racial groups.


METHODS
Longitudinal study of serum MIS levels in women of different race and ethnicity over two different time points.


METHODS
Women's Interagency HIV Study, a multicenter prospective cohort study.


METHODS
Serum samples obtained from 809 participants (122 white, 462 black, and 225 Hispanic women).


METHODS
Comparison of serum MIS between women of different race and ethnicity at two time points (median age 37.5 years and 43.3 years).


METHODS
Variation in MIS by race and ethnicity over time, controlling for age, body mass index, HIV status, and smoking.


RESULTS
Compared with white women, average MIS values were lower among black (25.2% lower) and Hispanic (24.6% lower) women, adjusting for age, body mass index, smoking, and HIV status.


CONCLUSIONS
There is an independent effect of race and ethnicity on the age-related decline in MIS over time.
Seifer
David B
DB
Department of Obstetrics and Gynecology, Brooklyn, and Mount Sinai School of Medicine, Maimonides Medical Center, New York, New York 11228, USA. drseifer@genesisfertility.com
Golub
Elizabeth T
ET
Lambert-Messerlian
Geralyn
G
Benning
Lorie
L
Anastos
Kathryn
K
Watts
D Heather
DH
Cohen
Mardge H
MH
Karim
Roksana
R
Young
Mary A
MA
Minkoff
Howard
H
Greenblatt
Ruth M
RM
D000328:Adult; D000375:Aging / Q000097:blood / Q000208:ethnology; D054304:Anti-Mullerian Hormone / Q000097:blood*; D044383:Black People / Q000706:statistics & numerical data; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006630:Hispanic or Latino / Q000706:statistics & numerical data; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D010053:Ovary / Q000502:physiology; D044465:White People / Q000706:statistics & numerical data
D054304:Anti-Mullerian Hormone