Mouse genetic models: an ideal system for understanding glaucomatous neurodegeneration and neuroprotection.
Here we review how mouse studies are contributing to understanding glaucoma. We include discussion of aqueous humor drainage and intraocular pressure elevation, because new treatments to avoid exposure to high pressure will indirectly protect neurons from glaucoma, and complement direct neuroprotective strategies. We describe how mouse models are adding to both the understanding of glaucomatous neurodegeneration and the development of neuroprotective strategies.
Howell
Gareth R
GR
The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
Libby
Richard T
RT
John
Simon W M
SW
D000818:Animals; D001082:Aqueous Humor; D004195:Disease Models, Animal; D005901:Glaucoma / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure; D051379:Mice; D008815:Mice, Inbred Strains; D008957:Models, Genetic; D009410:Nerve Degeneration / Q000473:pathology / Q000503:physiopathology; D018696:Neuroprotective Agents; D012165:Retinal Ganglion Cells / Q000166:cytology / Q000378:metabolism; D014065:Tonometry, Ocular / Q000379:methods; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D018696:Neuroprotective Agents; D014409:Tumor Necrosis Factor-alpha