title: MLXIPL variant in individuals with low and high triglyceridemia in white population in Central Europe.
abstract: We tested the hypothesis that the MLXIPL rs3812316 variant predicts plasma triglyceride (TG) levels. We compared three groups of adult individuals: 162 persons with TG > 10 mmol/L, 266 persons with TG < 0.65 mmol/L, and 2,043 population-based controls (range of TG concentrations 0.7-8.7 mmol/L). We found a small difference in the frequency of the Gln allele carriers between population controls (20.4%) and persons with low TG (26.3%, P = 0.033). We found no difference between individuals with high TG and population controls, and there was no association between the MLXIPL variant and plasma TG levels among the population controls.
authors.affiliation: 3rd Internal Department, 1st Medical Faculty, Charles University, Prague, Czech Republic.
authors.forename: Michal
authors.initials: M
authors.lastname: Vrablik
authors.forename: Richard
authors.initials: R
authors.lastname: Ceska
authors.forename: Vera
authors.initials: V
authors.lastname: Adamkova
authors.forename: Anne
authors.initials: A
authors.lastname: Peasey
authors.forename: Hynek
authors.initials: H
authors.lastname: Pikhart
authors.forename: Ruzena
authors.initials: R
authors.lastname: Kubinova
authors.forename: Michael
authors.initials: M
authors.lastname: Marmot
authors.forename: Martin
authors.initials: M
authors.lastname: Bobak
authors.forename: Jaroslav A
authors.initials: JA
authors.lastname: Hubacek
mesh_terms: D000328:Adult; D000368:Aged; D019943:Amino Acid Substitution; D001483:Base Sequence; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000235:genetics*; D016022:Case-Control Studies; D018153:Czech Republic; D004247:DNA / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014280:Triglycerides / Q000097:blood*; D044465:White People / Q000235:genetics
chemical_list: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; C116385:MLXIPL protein, human; D014280:Triglycerides; D004247:DNA