HIV-associated nephropathy in Caucasians: case report and review of literature.
HIV-associated nephropathy (HIVAN) is almost exclusively seen in African-Americans (AA) and is rare in Caucasians. The mechanisms responsible for the predilection of HIVAN in AA are not well understood. In transgenic mouse studies, genetic background plays a vital role in the development of the HIVAN phenotype. Larger studies in humans have been initiated to study genetic polymorphisms responsible for HIVAN. As our case illustrates, HIVAN should be considered in Caucasian patients with HIV infection complicated by nephrotic syndrome and renal failure.
Yalavarthy
R
R
Department of Renal Diseases and Hypertension, University of Colorado Denver, Health Sciences Center, Denver, CO 80262, USA. rajesh.yalavarthy@uchsc.edu
Smith
M L
ML
Edelstein
C L
CL
D016263:AIDS-Associated Nephropathy / Q000208:ethnology* / Q000473:pathology*; D017088:AIDS-Related Opportunistic Infections / Q000208:ethnology*; D001741:Black or African American; D018791:CD4 Lymphocyte Count; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D008875:Middle Aged; D044465:White People