Hepatoprotective activity of Phyllanthus reticulatus.
Two partially purified organic fractions designated by PR1 and PR2 of the fat free ethanol (95%) extract of aerial parts of Phyllanthus reticulatus were tested for the hepatoprotective activity in rats against CCl(4)-induced liver damage. The rats receiving the fractions showed promising hepatoprotective activity as evident from significant changes of pentobarbital-induced sleeping time, changes in serum levels of sGPT, sGOT, sALP and bilirubin and also from histopathological changes as compared to CCl(4)-intoxicated rats.
Das
Biplab K
BK
Department of Pharmacy, East West University, Mohakhali, Dhaka-1212, Bangladesh.
Bepary
Sukumar
S
Datta
Bidyut K
BK
Chowdhury
Ak Azad
AA
Ali
Mohammad Shawkat
MS
Rouf
Abu Shara  Shamsur
AS
D000818:Animals; D015415:Biomarkers / Q000097:blood; D002251:Carbon Tetrachloride; D056486:Chemical and Drug Induced Liver Injury; D004195:Disease Models, Animal; D019665:Euphorbiaceae / Q000737:chemistry; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008107:Liver Diseases / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D009336:Necrosis; D010634:Phenobarbital / Q000494:pharmacology; D035261:Plant Components, Aerial; D020011:Protective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D020318:Rats, Long-Evans; D012890:Sleep / Q000187:drug effects
D015415:Biomarkers; D006993:Hypnotics and Sedatives; D020011:Protective Agents; D002251:Carbon Tetrachloride; D010634:Phenobarbital