[Evaluation of ventricular function in patients with coronary artery disease: role of Gated-PET].
Positron emission tomography (PET), in its synchronized mode, also known as Gated-PET, is a powerful diagnostic tool in ischemic cardiopathy. This technique allows adding information regarding cardiovascular system functionality to traditionally PET-generated data on myocardial perfusion and endothelial function. With the aid of radiopharmaceuticals such as nitrogen-13 (13N) and 82-rubidium (82Rb), both with ultra-short half-lives, it's possible to perform a myocardial dynamic evaluation. Recently, our group has begun the first protocol ever in Latin America to include Gated-PET. From a group of 20 patients, in 14 of them (70%), it was possible to diagnose myocardial ischemia. In 13 from those patients, a significant decrease in the left ventricular ejection fraction (LVEF) during pharmacological onset with adenosine, was observed. In 6 patients (30%), myocardial ischemia was undiagnosed. After the analysis of Gated-PET data, we found that in 5 of them, LVEF was increased during pharmacological onset with adenosine. In healthy subjects, normal behavior consists of a LVEF increase in order to compensate body metabolic demands.
Alexánderson Rosas
Erick
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Departamento de Cardiología Nuclear y Tomografía Cardíaca, Instituto Nacional de Cardiología "Dr. Ignacio Chávez", México, DF. alexanderick@yahoo.com
D055424:Cardiac-Gated Imaging Techniques; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D006801:Humans; D049268:Positron-Emission Tomography; D016276:Ventricular Function