Immune privilege for stem cells: not as simple as it looked.
A recent paper in PNAS (Swijnenburg et al., 2008) reveals that human embryonic stem cells are not immune privileged. Potential therapeutic use of these cells will thus depend on the development of new strategies to counter foreign graft rejection by patient immune systems.
Chidgey
Ann P
AP
Monash Immunology and Stem Cell Laboratories, Level 3, Building-75, Monash University, Wellington Road, Clayton, Melbourne, Victoria 3800, Australia.
Boyd
Richard L
RL
D000818:Animals; D002454:Cell Differentiation / Q000276:immunology*; D053595:Embryonic Stem Cells / Q000166:cytology / Q000276:immunology*; D006084:Graft Rejection / Q000276:immunology; D006649:Histocompatibility Antigens / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D007110:Immunity, Active; D007150:Immunohistochemistry; D008164:Luminescent Proteins; D051379:Mice; D033581:Stem Cell Transplantation; D013997:Time Factors; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
D006649:Histocompatibility Antigens; D008164:Luminescent Proteins