title: Fracturing rings to understand lantibiotics.
abstract: Haloduracin is a bacterially produced antibiotic system of two alkali-stable peptides (Halalpha and Halbeta) that have extensive posttranslational modifications, including lanthionine rings. Now, Cooper et al. (2008) revise the structure of Halbeta and demonstrate that some of the lanthionine rings are not essential for bioactivity.
authors.affiliation: Department of Chemistry, University of Alberta, Edmonton, AB T6G 2G2, Canada.
authors.forename: Sabesan
authors.initials: S
authors.lastname: Yoganathan
authors.forename: John C
authors.initials: JC
authors.lastname: Vederas
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000737:chemistry; D001407:Bacillus / Q000737:chemistry / Q000378:metabolism; D001430:Bacteriocins / Q000096:biosynthesis / Q000737:chemistry* / Q000378:metabolism; D006801:Humans
chemical_list: D000900:Anti-Bacterial Agents; D001430:Bacteriocins; C515824:haloduracin, Bacillus halodurans