title: Photocontact dermatitis to ketoprofen presenting with erythema multiforme.
abstract: A 74-year-old Japanese man developed erythema multiforme on the inner aspect of his left elbow where ketoprofen-containing tape was applied and exposed to sunlight, and the eruption subsequently spread to the four limbs and trunk. The lesions were successfully treated with systemic corticosteroids without recurrence. Lymphocyte stimulation tests with ketoprofen-photomodified peripheral blood mononuclear cells revealed that the patient had circulating lymphocytes reactive with a photohaptenic moiety of ketoprofen. To our knowledge, this is the first case of erythema multiforme induced by photocontact dermatitis. The presence of circulating photoantigen-reactive T cells seemed to induce erythema multiforme as an unusual manifestation in this patient.
authors.affiliation: Department of Dermatology, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Iseigaoka, Kitakyushu 807-8555, Japan.
authors.forename: Kunio
authors.initials: K
authors.lastname: Izu
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Hino
authors.forename: Hideka
authors.initials: H
authors.lastname: Isoda
authors.forename: Daiki
authors.initials: D
authors.lastname: Nakashima
authors.forename: Kenji
authors.initials: K
authors.lastname: Kabashima
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Tokura
mesh_terms: D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D017454:Dermatitis, Photoallergic / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D004892:Erythema Multiforme / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D007660:Ketoprofen / Q000009:adverse effects*; D008213:Lymphocyte Activation; D008297:Male
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007660:Ketoprofen