Serum ghrelin, leptin and resistin levels in adolescent girls with polycystic ovary syndrome.
OBJECTIVE
The aim of the present study was to investigate the levels of leptin, resistin and ghrelin in polycystic ovary syndrome (PCOS), and to assess their possible correlations with the hormonal and metabolic features of PCOS.


METHODS
Sixteen obese (ObPCOS) and 12 lean (LeanPCOS) subjects with PCOS and 19 obese control subjects were enrolled in the study.


RESULTS
Ghrelin, leptin and resistin concentrations were similar between groups when body mass index (BMI) was used as a covariate (P > 0.05). Mean androgen, SHBG, luteinizing hormone (LH) levels and luteinizing hormone/follicle-stimulating hormone (LH/FSH) ratio tended to be similar between polycystic ovary syndrome (PCOS) groups. However, when compared with the control group, SHBG was lower and androgen, LH levels and LH/FSH ratio were higher in the PCOS groups. Free testosterone levels significantly correlated with resistin (r = -0.38), SHBG correlated significantly with body mass index (BMI) (r = -0.45) and resistin (r = -0.67), LH/FSH ratio was significantly correlated with ghrelin (r = -0.52) and estradiol (E2) levels (r = 0.51).


CONCLUSIONS
ObPCOS and LeanPCOS groups having higher LH/FSH ratios and lower SHBG levels suggest that there could be factors other than adiposity responsible for the clinical features of PCOS patients. In the light of our results, those factors can be suggested as ghrelin and E2 for the elevated LH/FSH ratio and resistin for the lowered SHBG.
Bideci
Aysun
A
Gazi University Medical School, Department of Pediatric Endocrinology, Beşevler, Ankara, Turkey.
Camurdan
Mahmut Orhun
MO
Yeşilkaya
Ediz
E
Demirel
Fatma
F
Cinaz
Peyami
P
D000293:Adolescent; D005260:Female; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D020738:Leptin / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D052243:Resistin / Q000097:blood*
D054439:Ghrelin; D020738:Leptin; D052243:Resistin