Multi-target anti-inflammatory action of hepatocyte growth factor.
Hepatocyte growth factor (HGF) is a paracrine multifunctional pleiotropic cytokine. HGF has demonstrated potent anti-inflammatory activity in several animal models of disease and multiple organ systems. HGF suppresses inflammation by targeting multiple pathophysiological processes involved in inflammatory response, including activation of parenchymal cells, microvascular endothelial dysfunction, and leukocyte extravasation and chemotaxis. Mechanistically, this anti-inflammatory action functions by intercepting NFkappaB signaling and subsequently disrupting the expression of NFkappaB-dependent proinflammatory mediators. Thus, HGF might represent a novel integrated multiple-target approach to suppress inflammation and to lower the risk of complications from inflammatory injury.
Gong
Rujun
R
Brown University School of Medicine, Department of Medicine, Providence, RI 02903, USA. Rujun_Gong@brown.edu
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D038362:Glycogen Synthase Kinase 3 / Q000502:physiology; D000071679:Glycogen Synthase Kinase 3 beta; D017228:Hepatocyte Growth Factor / Q000494:pharmacology*; D006801:Humans; D016328:NF-kappa B / Q000037:antagonists & inhibitors; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D051057:Proto-Oncogene Proteins c-akt / Q000502:physiology; D015398:Signal Transduction
D000893:Anti-Inflammatory Agents; D016328:NF-kappa B; D017228:Hepatocyte Growth Factor; D019869:Phosphatidylinositol 3-Kinases; D000071679:Glycogen Synthase Kinase 3 beta; D051057:Proto-Oncogene Proteins c-akt; D038362:Glycogen Synthase Kinase 3