Reduced toxicity of fumonisin B1 in corn grits by single-screw extrusion.
Corn grits spiked with 30 microg/g fumonisin B1 and two batches of grits fermented with Fusarium verticillioides (batch 1 contained 33 microg/g, and batch 2 contained 48 microg/g fumonisin B1), which were extruded by a single-screw extruder with and without glucose (10%, dry weight basis) supplementation were fed to rats. Control groups were fed uncontaminated grits. Extrusion with glucose more effectively reduced fumonisin B1 concentrations of the grits (75 to 85%) than did extrusion alone (10 to 28%). With one exception, the fumonisin B1-spiked and fermented extrusion products caused moderately severe kidney lesions and reduced kidney weights, effects typically found in fumonisin-exposed rats. Lesions in rats fed the least contaminated grits (batch 1) after extrusion with 10% glucose were, however, significantly less severe and not accompanied by kidney weight changes. Therefore, extrusion with glucose supplementation is potentially useful for safely reducing the toxicity of fumonisins in corn-based products and studies to determine the optimal conditions for its use are warranted.
Voss
Kenneth A
KA
Russell Research Center, U.S. Department of Agriculture, Agricultural Research Station, 950 College Station Road, Athens, Georgia 30605, USA.
Bullerman
Lloyd B
LB
Bianchini
Andreia
A
Hanna
Milford A
MA
Ryu
Dojin
D
D000821:Animal Feed; D000818:Animals; D001681:Biological Assay; D005285:Fermentation; D005506:Food Contamination / Q000032:analysis*; D005511:Food Handling / Q000379:methods*; D037341:Fumonisins / Q000633:toxicity*; D005670:Fusarium / Q000378:metabolism; D005947:Glucose / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D003313:Zea mays / Q000737:chemistry* / Q000382:microbiology
D037341:Fumonisins; C056933:fumonisin B1; D005947:Glucose