A new osteonecrosis animal model of the femoral head induced by microwave heating and repaired with tissue engineered bone.
The objective of this research was to induce a new animal model of osteonecrosis of the femoral head (ONFH) by microwave heating and then repair with tissue engineered bone. The bilateral femoral heads of 84 rabbits were heated by microwave at various temperatures. Tissue engineered bone was used to repair the osteonecrosis of femoral heads induced by microwave heating. The roentgenographic and histological examinations were used to evaluate the results. The femoral heads heated at 55 degrees C for ten minutes showed low density and cystic changes in X-ray photographs, osteonecrosis and repair occurred simultaneously in histology at four and eight weeks, and 69% femoral heads collapsed at 12 weeks. The ability of tissue engineered bone to repair the osteonecrosis was close to that of cancellous bone autograft. The new animal model of ONFH could be induced by microwave heating, and the tissue engineering technique will provide an effective treatment.
Li
Yanlin
Y
Department of Orthopaedics, The First Affiliated Hospital of Kunming Medical College, Kunming, People's Republic of China. yanlinli1969@yahoo.com.cn
Han
Rui
R
Geng
Chengkui
C
Wang
Yongnian
Y
Wei
Lei
L
D000704:Analysis of Variance; D000818:Animals; D015519:Bone Density / Q000502:physiology; D019485:Bone Morphogenetic Proteins / Q000494:pharmacology; D016025:Bone Transplantation / Q000379:methods*; D004195:Disease Models, Animal; D005271:Femur Head Necrosis / Q000473:pathology* / Q000601:surgery*; D006084:Graft Rejection; D006085:Graft Survival; D007150:Immunohistochemistry; D008872:Microwaves; D010012:Osteogenesis / Q000502:physiology; D011336:Probability; D011817:Rabbits; D011897:Random Allocation; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D023822:Tissue Engineering; D014182:Transplantation, Autologous
D019485:Bone Morphogenetic Proteins