title: Haemostatic effects of adrenaline-lidocaine subcutaneous infiltration at donor sites.
abstract: This study sought methods in burn surgery to reduce postoperative pain and blood loss at donor sites. A prospective, randomised, controlled, blinded trial included 56 people undergoing burn surgery, divided into two groups. Both groups received subcutaneous infiltration at donor sites, with either 1:500,000 adrenaline solution containing added lidocaine or with 0.45% normal saline (controls). Outcome measurements included amount of intraoperative bleeding, need for electrocautery, days the hydrocolloid dressing remained on donor sites, percentage of re-epithelialised skin at donor sites 1 week after surgery and viability of skin grafts. Results indicated that subcutaneous adrenaline-lidocaine infiltration at donor sites reduced intraoperative bleeding, decreased postoperative pain, shortened the duration of surgery and general anaesthesia and accelerated re-epithelialisation at the donor site. The overall graft take in both groups was similar.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Virgen del Rocío University Hospitals, Sevilla, Spain. purigacto@gmail.com
authors.forename: P
authors.initials: P
authors.lastname: Gacto
authors.forename: F
authors.initials: F
authors.lastname: Miralles
authors.forename: J J
authors.initials: JJ
authors.lastname: Pereyra
authors.forename: A
authors.initials: A
authors.lastname: Perez
authors.forename: E
authors.initials: E
authors.lastname: Martínez
mesh_terms: D000328:Adult; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D002056:Burns / Q000188:drug therapy / Q000601:surgery*; D016022:Case-Control Studies; D004564:Electrocoagulation / Q000706:statistics & numerical data; D004837:Epinephrine / Q000008:administration & dosage*; D005260:Female; D006488:Hemostasis, Surgical / Q000379:methods*; D006801:Humans; D007279:Injections, Subcutaneous; D007430:Intraoperative Care / Q000379:methods; D008012:Lidocaine / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy / Q000517:prevention & control; D011446:Prospective Studies; D016038:Skin Transplantation / Q000379:methods; D014662:Vasoconstrictor Agents / Q000008:administration & dosage*; D014945:Wound Healing / Q000502:physiology
chemical_list: D014662:Vasoconstrictor Agents; D008012:Lidocaine; D004837:Epinephrine