Uapaca genus (Euphorbiaceae), a good source of betulinic acid.
Betulinic acid, isolated in substantial amounts from stem barks of five distinct species of Uapaca could be considered as an important chemotaxomic marker of the Uapaca genus. It inhibited Trypanosoma brucei GAPDH with an IC(50) value of 240 microM and has been shown to be a competitive reversible inhibitor (Ki=200+/-10 microM) of this enzyme with respect to its cofactor NAD(+).
Nyasse
Barthelemy
B
Laboratory of Medicinal Chemistry, Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Box 812 Yaoundé, Cameroon. bnyasse@yahoo.com
Nono
Jean-Jules
JJ
Nganso
Yves
Y
Ngantchou
Igor
I
Schneider
Bernd
B
D000818:Animals; D019665:Euphorbiaceae / Q000737:chemistry*; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000037:antagonists & inhibitors*; D015394:Molecular Structure; D009243:NAD / Q000037:antagonists & inhibitors*; D053978:Pentacyclic Triterpenes; D024301:Plant Bark; D010936:Plant Extracts / Q000493:pharmacokinetics / Q000494:pharmacology*; D018547:Plant Stems; D014315:Triterpenes / Q000302:isolation & purification* / Q000493:pharmacokinetics / Q000494:pharmacology; D014346:Trypanosoma brucei brucei / Q000201:enzymology*; D000094062:Betulinic Acid
D053978:Pentacyclic Triterpenes; D010936:Plant Extracts; D014315:Triterpenes; D009243:NAD; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D000094062:Betulinic Acid