title: Management of asymptomatic severe aortic stenosis.
abstract: Patients with symptomatic severe aortic stenosis (AS) benefit from aortic valve replacement (AVR). Management of severe AS in the absence of symptoms is, however, controversial and often challenging. Unselected premature AVR carries the risks of cardiac surgery; delayed AVR due to unrecognized symptoms can result in a dismal outcome. Echocardiography is the standard tool to evaluate and follow patients with AS. Nevertheless, most of the current echocardiographic parameters have limitations in predicting symptom onset and clinical outcome. The same applies to clinical parameters, exercise stress testing, and other imaging modalities used in AS evaluation and serial follow-up. Predictors of outcome could, however, help to identify asymptomatic patients who would benefit from expedited AVR with the goal to reduce mortality. This review will discuss the most relevant clinical studies and guidelines on management of asymptomatic severe AS, with an emphasis on providing concise information for identifying patients at high risk.
authors.affiliation: Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Jacob P
authors.initials: JP
authors.lastname: Dal-Bianco
authors.forename: Bjoy K
authors.initials: BK
authors.lastname: Khandheria
authors.forename: Farouk
authors.initials: F
authors.lastname: Mookadam
authors.forename: Federico
authors.initials: F
authors.lastname: Gentile
authors.forename: Partho P
authors.initials: PP
authors.lastname: Sengupta
mesh_terms: D000368:Aged; D000800:Angioplasty, Balloon / Q000379:methods* / Q000401:mortality; D001024:Aortic Valve Stenosis / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy*; D015150:Echocardiography, Doppler; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D019918:Heart Valve Prosthesis Implantation / Q000379:methods* / Q000401:mortality; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011183:Postoperative Complications / Q000175:diagnosis / Q000401:mortality; D011237:Predictive Value of Tests; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment; D012720:Severity of Illness Index; D013318:Stroke Volume; D016019:Survival Analysis