title: Evaluation of biocompatibility and mechanical behavior of polyurethane elastomers based on chitin/1,4-butane diol blends.
abstract: Chitin based polyurethane elastomers with potential as biomedical implants with tunable mechanical properties were synthesized by step growth polymerization techniques using poly(epsilon-caprolactone) (PCL) and 4,4'-diphenylmethane diisocyanate (MDI). The prepolymer was extended with different mass ratios of chitin and 1,4-butane diol (BDO). Molecular characterization was done using FTIR, 1H NMR and 13C NMR techniques. The mechanical properties of these polymers were improved with increase in the chitin contents. Optimum mechanical properties were obtained from elastomers extended with chitin in comparison to elastomers extended with BDO. Cytotoxicity of the synthesized polyurethane samples was affected by varying the chitin contents in the chemical composition of the final polyurethane (PU). It is revealed that the final polymers extended with chitin are preferred candidates for surgical threads with on going investigations into their in vitro biocompatibility and non-toxicity.
authors.affiliation: Department of Chemistry, University of Agriculture, Faisalabad 38040, Pakistan.
authors.forename: Khalid Mahmood
authors.initials: KM
authors.lastname: Zia
authors.forename: Mohammad
authors.initials: M
authors.lastname: Zuber
authors.forename: Ijaz Ahmad
authors.initials: IA
authors.lastname: Bhatti
authors.forename: Mehdi
authors.initials: M
authors.lastname: Barikani
authors.forename: Munir Ahmad
authors.initials: MA
authors.lastname: Sheikh
mesh_terms: D002073:Butanes / Q000737:chemistry*; D002686:Chitin / Q000737:chemistry*; D020724:Elastomers / Q000138:chemical synthesis / Q000737:chemistry*; D017953:Isocyanates; D008422:Materials Testing; D055595:Mechanical Phenomena; D019906:Nuclear Magnetic Resonance, Biomolecular; D011091:Polyesters; D011140:Polyurethanes / Q000138:chemical synthesis / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013537:Sutures; D001559:Benzhydryl Compounds
chemical_list: D002073:Butanes; D002686:Chitin; D020724:Elastomers; D017953:Isocyanates; D011091:Polyesters; D011140:Polyurethanes; C016240:polycaprolactone; C005969:4,4'-diphenylmethane diisocyanate; D001559:Benzhydryl Compounds