Polymorphism of glutathione S-transferase Omega gene: association with risk of childhood acute lymphoblastic leukemia.
OBJECTIVE
To evaluate the association between glutathione S-transferase Omega (GSTO) genes polymorphism and the susceptibility of acute lymphoblast leukemia (ALL).


METHODS
The polymorphism of GSTO1 and GSTO2 genes were analyzed in 99 ALL patients compared with 100 healthy children by PCR-based restriction fragment length polymorphism (RFLP) analysis.


RESULTS
GSTO1*A140D polymorphism was significantly associated with susceptibility to ALL (OR = 2.24, 95% CI = 1.16-4.35, P = 0.009) whereas, GSTO2*N142D genotype was significantly interacted with high risk group of childhood ALL (OR = 5.52, 95% CI = 1.72-17.71, P = 0.004).


CONCLUSIONS
This study revealed gene polymorphism in glutathione S-transferase Omega class may be a risk factor to the development of acute childhood lymphoblastic leukemia.
Pongstaporn
W
W
Faculty of Medical Technology, Rangsit University, Pathum thani, Thailand.
Pakakasama
S
S
Sanguansin
S
S
Hongeng
S
S
Petmitr
Songsak
S
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003062:Codon / Q000235:genetics; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D004273:DNA, Neoplasm / Q000235:genetics / Q000302:isolation & purification; D005091:Exons / Q000235:genetics; D005260:Female; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007223:Infant; D008297:Male; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000201:enzymology / Q000235:genetics*; D012016:Reference Values; D012189:Retrospective Studies
D003062:Codon; D004273:DNA, Neoplasm; D004247:DNA; C490476:GSTO1 protein, human; C492569:GSTO2 protein, human; D005982:Glutathione Transferase