title: Neonatal gastric perforation: report of 15 cases and review of the literature.
abstract: BACKGROUND
  Gastric perforation among neonates is a rare but frequently fatal condition of uncertain etiology. The aim of this study was to review the clinical course of neonatal gastric perforation and to evaluate possible prognostic factors.
  
  
  METHODS
  We retrospectively analyzed the medical records of 15 patients with neonatal gastric perforation over a 19-year period. Another 97 patients described in the medical literature, for whom the gestational ages and birth weights were clearly stated, were also reviewed.
  
  
  RESULTS
  In our series, there were three girls and 12 boys, nine of whom were full-term infants and six preterm infants. The most common initial manifestations were poor activity, abdominal distension, and respiratory distress. The overall mortality was 47% (7/15). Prematurity was the only statistically significant risk factor; 83% (5/6) of premature infants died compared with 22% (2/9) of term babies (p < 0.05). Combining our series with the patients reported in the literature, there were a total of 50 premature infants and 62 term infants. Gastric perforation occurred on postnatal days 2-7 and presented with nonspecific manifestations. The mortality was significantly higher in premature than in term infants (31/50, 62% vs. 16/62, 26%; p < 0.001). A trend towards higher mortality in infants with lower birth weights was observed (>2500 g, 28%; 1501-2500 g, 52%; 1000-1500 g, 60%; <1000 g, 100%). Infants with birth weights <2500 g had a significantly higher mortality than infants with birth weights >2500 g (32/58, 55% vs. 15/54, 28%; p<0.05).
  
  
  CONCLUSIONS
  Neonatal gastric perforation is associated with high mortality, particularly in premature infants. There is also a trend towards higher mortality in lower-birth-weight infants.
authors.affiliation: Department of Pediatrics, Jen-Ai Hospital, Taichung, Taiwan.
authors.forename: Chieh-Mo
authors.initials: CM
authors.lastname: Lin
authors.forename: Hung-Chang
authors.initials: HC
authors.lastname: Lee
authors.forename: Hsin-An
authors.initials: HA
authors.lastname: Kao
authors.forename: Han-Yang
authors.initials: HY
authors.lastname: Hung
authors.forename: Chyong-Hsin
authors.initials: CH
authors.lastname: Hsu
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: Yeung
authors.forename: Jin-Cherng
authors.initials: JC
authors.lastname: Sheu
authors.forename: Nien-Lu
authors.initials: NL
authors.lastname: Wang
mesh_terms: D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000209:etiology / Q000401:mortality* / Q000628:therapy; D007234:Infant, Premature; D008297:Male; D013275:Stomach Rupture / Q000209:etiology / Q000401:mortality* / Q000628:therapy