Angiogenesis in pre-malignant conditions.
Evidence from human studies suggests that angiogenesis commences during the pre-malignant stages of cancer. Inhibiting angiogenesis may, therefore, be of potential value in preventing progression to invasive cancer. Understanding the mechanisms inducing angiogenesis in these lesions and identification of those important in human tumourigenesis are necessary to develop translational strategies that will help realise the goal of angioprevention.
Menakuru
S R
SR
Microcirculation Research Group, Academic Surgical Oncology Unit, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield S10 2JF, UK.
Brown
N J
NJ
Staton
C A
CA
Reed
M W R
MW
D000818:Animals; D006801:Humans; D000860:Hypoxia / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D011230:Precancerous Conditions / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D012307:Risk Factors