[The comparative effect of the tetrapeptides and amino acids on the organotypic culture of tissues of young and old rats].
The effect of the synthetic tetrapeptides and amino acids composing them, in concentration 10(-12) M, was investigated in organotypic tissue culture on the cell proliferation and apoptosis development in six tissue explants (ecto-, meso- and entodermal genesis) in 3 and 24 months old rats. The tetrapeptides demonstrated the greater tissue-specificity, as compared to the amino acids. Each tetrapeptide stimulated proliferation in only one corresponded tissue type. The amino acids stimulated proliferation and apoptosis in three-five tissues. It can be suggested, that tissue-specificity in these biologically active substances is depended on the structure complexity. An active amino acids number decreased in old tissues, but tetrapeptides stimulated proliferation both in young and old tissues.
Morozova
P Iu
PIu
Chalisova
N I
NI
Zakutskiĭ
A N
AN
Lesniak
V V
VV
D000375:Aging / Q000187:drug effects* / Q000473:pathology; D000596:Amino Acids / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D008297:Male; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology*; D009928:Organ Specificity; D051381:Rats; D017208:Rats, Wistar; D046509:Tissue Culture Techniques / Q000379:methods*
D000596:Amino Acids; D009842:Oligopeptides