title: E-cadherin tissue expression and urinary soluble forms of E-cadherin in patients with bladder transitional cell carcinoma.
abstract: OBJECTIVE
  To investigate the clinical significance of E-cadherin (E-CD) expression in human bladder transitional cell carcinoma (TCC) tissue and soluble forms of E-cadherin (sE-CD) in the urine of patients with TCC.
  
  
  METHODS
  One hundred and two specimens of bladder TCC and 10 normal bladder tissues were stained immunohistochemically with anti-E-CD monoclonal antibody. The urinary sE-CD from 59 subjects with TCC or controls was measured with enzyme-linked immunosorbent assay (ELISA). All results were analyzed statistically between groups.
  
  
  RESULTS
  The expression of E-CD in bladder TCC correlated well with grade and stage but had no significant correlation with the size or number of the tumors. Normal expression rate of E-CD is significantly higher in primary than in recurrent tumors. The level of urinary sE-CD was higher in patients with TCC than in normal controls or patients with benign disorders of the urinary system. Urinary sE-CD levels were strongly correlated with tumor grade but showed no significant correlation with the stage, size and number of the tumors. The urinary sE-CD level is significantly higher in the recurrent group than in the primary group.
  
  
  CONCLUSIONS
  Expression of E-CD in the tissue of TCC and the urinary level of sE-CD are very closely associated with the biological behaviors of bladder TCC.
authors.affiliation: Department of Urology, Qilu Hospital of Shandong University, Jinan, China.
authors.forename: Benkang
authors.initials: B
authors.lastname: Shi
authors.forename: Vincent
authors.initials: V
authors.lastname: Laudon
authors.forename: Shengqiang
authors.initials: S
authors.lastname: Yu
authors.forename: Dexin
authors.initials: D
authors.lastname: Dong
authors.forename: Yaofeng
authors.initials: Y
authors.lastname: Zhu
authors.forename: Zhishun
authors.initials: Z
authors.lastname: Xu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000652:urine; D015820:Cadherins / Q000032:analysis* / Q000652:urine; D002295:Carcinoma, Transitional Cell / Q000737:chemistry* / Q000473:pathology / Q000652:urine; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D001749:Urinary Bladder Neoplasms / Q000737:chemistry* / Q000473:pathology / Q000652:urine
chemical_list: D014408:Biomarkers, Tumor; D015820:Cadherins