title: Two new bioactive oleanane triterpene glycosides from Terminalia arjuna.
abstract: Two new oleanane-type triterpene glycosides designated as Termiarjunoside I and Termiarjunoside II were isolated from stem bark of Terminalia arjuna (Combretaceae) and characterized as olean-1alpha,3beta,9alpha,22alpha-tetraol-12-en-28-oic acid-3beta-D-glucopyranoside (1) and olean-3alpha,5alpha,25-triol-12-en-23,28-dioic acid-3alpha-D-glucopyranoside (2) based on chemical and spectral data evidences. Both compounds 1 and 2 potently suppressed the release of nitric oxide and superoxide from macrophages and also inhibited aggregation of platelets.
authors.affiliation: Faculty of Science, Department of Chemistry, Jamia Hamdard, New Delhi 110062, India. msalamchem@yahoo.com
authors.forename: M Sarwar
authors.initials: MS
authors.lastname: Alam
authors.forename: Gurpreet
authors.initials: G
authors.lastname: Kaur
authors.forename: Asif
authors.initials: A
authors.lastname: Ali
authors.forename: Hinna
authors.initials: H
authors.lastname: Hamid
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ali
authors.forename: Mohammad
authors.initials: M
authors.lastname: Athar
mesh_terms: D002851:Chromatography, High Pressure Liquid; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D008264:Macrophages / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D016339:Spectrometry, Mass, Fast Atom Bombardment; D029766:Terminalia / Q000737:chemistry*
chemical_list: D006027:Glycosides; D009828:Oleanolic Acid