title: Functionalized analogues of an unnatural amino acid that mimics a tripeptide beta-strand.
abstract: This paper introduces polar and hydrophobic variants of the unnatural amino acid Hao, which mimics the hydrogen-bonding functionality of one edge of a beta-strand. In these variants, the methyl side chain of Hao is replaced with acidic, basic, and hydrophobic groups. These modifications can impart improved solubility and additional side-chain interactions to peptides containing Hao.
authors.affiliation: Department of Chemistry, University of California, Irvine, Irvine, California 92697-2025, USA.
authors.forename: Tatyana V
authors.initials: TV
authors.lastname: Khasanova
authors.forename: Omid
authors.initials: O
authors.lastname: Khakshoor
authors.forename: James S
authors.initials: JS
authors.lastname: Nowick
mesh_terms: D000596:Amino Acids / Q000737:chemistry* / Q000378:metabolism*; D040761:Biomimetic Materials / Q000737:chemistry* / Q000378:metabolism*; D006860:Hydrogen Bonding; D009842:Oligopeptides / Q000737:chemistry* / Q000378:metabolism; D017510:Protein Folding; D017433:Protein Structure, Secondary; D012995:Solubility
chemical_list: D000596:Amino Acids; D009842:Oligopeptides