Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis.
The screening of a diversity-oriented synthesis library followed by structure-activity relationship investigations have led to the discovery of an anti-MRSA agent which operates as an inhibitor of Staphylococcus aureus dihydrofolate reductase.
Wyatt
Emma E
EE
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK.
Galloway
Warren R J D
WR
Thomas
Gemma L
GL
Welch
Martin
M
Loiseleur
Olivier
O
Plowright
Alleyn T
AT
Spring
David R
DR
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005493:Folic Acid Antagonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000201:enzymology*; D013329:Structure-Activity Relationship; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D005493:Folic Acid Antagonists; D013762:Tetrahydrofolate Dehydrogenase