Coagulation and fibrinolytic systems during liver regeneration in the early period after adult living related partial liver transplantation.
In this study, we investigated the differences in the perioperative blood coagulation and fibrinolytic systems (BCF) between donor and recipient after adult living related partial liver transplantation (ALRPLT), with particular reference to serum plasminogen-activator inhibitor-1 (PAI-1) and soluble fibinogen level. The BCF were unstable in the recipient compared with the donor. The recipient fibrinolytic system was the same as the donor system except for PAI-1, which was remarkably increased on day 1 after transplantation in the recipient. The recipient is thought to have disseminated intravascular coagulation in the early period after ALRPLT. Soluble fibrinogen may be a useful marker for improvement in the BCF system. The elevation of PAI-1 in recipients on day 1 after transplantation may be a marker of injury from the shear stress from excessive portal hypertension after ALRPLT.
Sato
Y
Y
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan. kanishok@med.niigata-u.ac.jp
Nakatsuka
H
H
Yamamoto
S
S
Oya
H
H
Kobayashi
T
T
Watanabe
T
T
Kokai
H
H
Kurosaki
I
I
Shirai
Y
Y
Hatakeyama
K
K
D000293:Adolescent; D000328:Adult; D001777:Blood Coagulation; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D005342:Fibrinolysis; D006801:Humans; D016031:Liver Transplantation / Q000502:physiology*; D019520:Living Donors / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D010976:Platelet Count; D011184:Postoperative Period; D012189:Retrospective Studies
D017395:Plasminogen Activator Inhibitor 1; D005340:Fibrinogen