title: The role of penicillin G potassium in managing Clostridium perfringens in broiler chickens.
abstract: The efficacy of penicillin G potassium (Pot-Pen) administered via drinking water to manage necrotic enteritis (NE) was investigated in a Clostridium perfringens (CP) challenge study using 1600 broiler chickens assigned to one of four treatment groups: nonchallenged, nonmedicated; challenged, nonmedicated; challenged, Pot-Pen 0.2 g/L; challenged, Pot-Pen 0.4 g/L. Overall mortality due to NE was significantly reduced among Pot-Pen-treated pens; mortality due to other causes did not differ among the treatment groups. Among all birds, growth performance parameters were significantly improved among Pot-Pen-treated pens. When considering birds randomly sacrificed 4 days post-Pot-Pen initiation, mean NE lesion scores were greatest among the challenged, nonmedicated pens; only one of 80 randomly sacrificed birds treated with Pot-Pen had NE lesions. Among the nonmedicated control pens, body weight (BW) was significantly greater among birds that did not have NE-associated lesions. When sacrificed birds were stratified by NE lesion score, there were no significant differences in BW among the treatment groups. Results of this study suggest that CP-associated subclinical disease can significantly reduce broiler performance. Furthermore, the positive effects of treatment with Pot-Pen appeared to be associated with the prevention and/or treatment of NE-specific lesions.
authors.affiliation: Vetoquinol N.A. Inc., 2000 Chemin Georges, Lavlatrie, Québec, Canada J0K 1H0. pgadbois@vetoquinol.ca
authors.forename: P
authors.initials: P
authors.lastname: Gadbois
authors.forename: J J
authors.initials: JJ
authors.lastname: Brennan
authors.forename: L
authors.initials: L
authors.lastname: Bruce
authors.forename: J B
authors.initials: JB
authors.lastname: Wilson
authors.forename: J J
authors.initials: JJ
authors.lastname: Aramini
mesh_terms: D000818:Animals; D001835:Body Weight; D002645:Chickens; D003015:Clostridium Infections / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D003016:Clostridium perfringens / Q000187:drug effects*; D004751:Enteritis / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000662:veterinary*; D010400:Penicillin G / Q000494:pharmacology*; D011201:Poultry Diseases / Q000188:drug therapy* / Q000382:microbiology* / Q000473:pathology
chemical_list: D010400:Penicillin G