title: Isolation, structure and fatty acid synthesis inhibitory activities of platensimycin B1-B3 from Streptomyces platensis.
abstract: Platensimycins B(1)-B(3) are natural congeners of platensimycin with modest to significant changes in the benzoic acid portion of the molecule, leading to attenuation in the biological activities and thus confirming the significance of the free carboxylate for the potent activity.
authors.affiliation: Merck Research Laboratories, Rahway, New Jersey 07065, USA.
authors.forename: Chaowei
authors.initials: C
authors.lastname: Zhang
authors.forename: John
authors.initials: J
authors.lastname: Ondeyka
authors.forename: Deborah L
authors.initials: DL
authors.lastname: Zink
authors.forename: Bruce
authors.initials: B
authors.lastname: Burgess
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Sheo B
authors.initials: SB
authors.lastname: Singh
mesh_terms: D015099:3-Oxoacyl-(Acyl-Carrier-Protein) Synthase / Q000037:antagonists & inhibitors / Q000378:metabolism; D000218:Adamantane / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D062365:Aminobenzoates / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D000813:Anilides / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D005227:Fatty Acids / Q000096:biosynthesis*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000201:enzymology; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D062365:Aminobenzoates; D000813:Anilides; D000900:Anti-Bacterial Agents; D005227:Fatty Acids; D015099:3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; D000218:Adamantane; C510909:platensimycin