The epsin 4 gene is associated with psychotic disorders in families of Latin American origin.
This study attempted to replicate evidence for association of the Epsin 4 gene (which encodes enthoprotin, a protein involved in vesicular transport) to schizophrenia in a new sample of families segregating schizophrenia drawn from the Latin American population. 1,423 subjects (767 with a history of psychosis) from 337 Latino families were genotyped using three single nucleotide polymorphisms (SNPs) spanning the Epsin 4 gene. A family based association test was utilized to test for association of these SNPs to the phenotypes of psychosis and schizophrenia. Haplotypes defined by these three SNPs showed significant association to the phenotype of psychosis in this sample (global p value=0.014, bi-allelic p value=0.047). Variation in the Epsin 4 gene is significantly associated with psychotic disorder in this Latino population. This provides additional support for the involvement of enthoprotin in the pathogenesis of schizophrenia and other psychotic disorders.
Escamilla
Michael
M
Psychiatric Genetics Research Center, Department of Psychiatry, University of Texas Health Science Center at San Antonio, TX 78229-3900, USA. escamillam@uthscsa.edu
Lee
Byung Dae
BD
Ontiveros
Alfonso
A
Raventos
Henriette
H
Nicolini
Humberto
H
Mendoza
Ricardo
R
Jerez
Alvaro
A
Munoz
Rodrigo
R
Medina
Rolando
R
Figueroa
Andres
A
Walss-Bass
Consuelo
C
Armas
Regina
R
Contreras
Salvador
S
Ramirez
Mercedes E
ME
Dassori
Albana
A
D033942:Adaptor Proteins, Vesicular Transport / Q000235:genetics*; D002489:Central America / Q000208:ethnology; D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D005190:Family; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D005838:Genotype; D006239:Haplotypes; D006630:Hispanic or Latino / Q000235:genetics*; D006801:Humans; D008800:Mexico / Q000208:ethnology; D010375:Pedigree; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011618:Psychotic Disorders / Q000235:genetics* / Q000503:physiopathology; D012559:Schizophrenia / Q000235:genetics / Q000503:physiopathology
D033942:Adaptor Proteins, Vesicular Transport; C475910:CLINT1 protein, human