Nanocomposites coated with xyloglucan for drug delivery: In vitro studies.
Enalaprilate (Enal), an active pharmaceutical component, was intercalated into a layered double hydroxide (Mg/Al-LDH) by an ion exchange reaction. The use of a layered double hydroxide (LDH) to release active drugs is limited by the low pH of the stomach (pH approximately 1.2), in whose condition it is readily dissolved. To overcome this limitation, xyloglucan (XG) extracted from Hymenaea courbaril (jatobá) seeds, Brazilian species, was used to protect the LDH and allow the drug to pass through the gastrointestinal tract. All the materials were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, elemental analyses, transmission electronic microscopy, thermal analyses, and a kinetic study of the in vitro release was monitored by ultraviolet spectroscopy. The resulting hybrid system containing HDL-Enal-XG(3) slowly released the Enal. In an 8-h of test, the system protected 40% (w/v) of the drug. The kinetic profile showed that the drug release was a co-effect behavior, involving dissolution of inorganic material and ion exchange between the intercalated anions in the lamella and those of phosphate in the buffer solution. The nanocomposite coated protection with XG was therefore efficient in obtaining a slow release of Enal.
Ribeiro
C
C
Laboratório de Biopolímeros, Departamento de Química, Universidade Federal do Paraná, C.P. 19081, 81531-980 Curitiba, Paraná, Brazil.
Arizaga
G G C
GG
Wypych
F
F
Sierakowski
M-R
MR
D000536:Aluminum Hydroxide / Q000737:chemistry; D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000737:chemistry; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D015773:Enalaprilat / Q000008:administration & dosage* / Q000737:chemistry; D041981:Gastrointestinal Tract / Q000378:metabolism; D005936:Glucans / Q000737:chemistry*; D006801:Humans; D008276:Magnesium Hydroxide / Q000737:chemistry; D008954:Models, Biological; D053761:Nanocomposites / Q000737:chemistry*; D012212:Rheology; D012995:Solubility; D014961:X-Ray Diffraction; D014990:Xylans / Q000737:chemistry*
D000959:Antihypertensive Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005936:Glucans; D014990:Xylans; C010467:hydrotalcite; C029353:xyloglucan; D000536:Aluminum Hydroxide; D015773:Enalaprilat; D008276:Magnesium Hydroxide