title: [Photodynamic therapy in age-related macular degeneration: one-year results].
abstract: OBJECTIVE
  To evaluate the efficacy of photodynamic therapy (PDT) for subfoveal choroidal neovascularization(CNV) secondary to age-related macular degeneration(AMD) one year after PDT.
  
  
  METHODS
  106 eyes of 106 AMD patients with subfoveal CNV detected by fluorescein angiography (FA). Best-corrected visual acuity, color fundus photography, FA and indocyanine green angiography were performed before and 1 year after treatment. Visual acuity and CNV size before PDT were compared with those 1 year after treatment. Pre-PDT factors predicting a visual acuity of 0.4 or more 1 year after this treatment were evaluated.
  
  
  RESULTS
  Visual acuity improved or was maintained in 84 of the 106 eyes. The size of CNV decreased significantly (p < 0.001). A visual acuity of 0.4 or more 1 year after PDT was predicted by an acuity of 0.4 or more (p = 0.01) and occult with no classic CNV (p = 0.04) prior to PDT.
  
  
  CONCLUSIONS
  PDT is effective for maintaining or improving visual acuity and obliteration of CNV for 1 year or longer. Factors predicting a visual acuity of 0.4 or more 1 year after PDT were an acuity of 0.4 or more and occult with no classic CNV prior to PDT.
authors.affiliation: Division of Ophthalmology, Department of Visual Science, Nihon University School of Medicine, Japan. tkasuminn@yahoo.co.jp
authors.forename: Kasumi
authors.initials: K
authors.lastname: Ohira-Tochigi
authors.forename: Eisei
authors.initials: E
authors.lastname: Yokoyama
authors.forename: Yoko
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Tetsuhiro
authors.initials: T
authors.lastname: Kyo
authors.forename: Mitsuko
authors.initials: M
authors.lastname: Yuzawa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020256:Choroidal Neovascularization / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008268:Macular Degeneration / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy; D016896:Treatment Outcome; D014792:Visual Acuity