title: Bioengineering strategies to generate vascularized soft tissue grafts with sustained shape.
abstract: Tissue engineering offers the possibility for soft tissue reconstruction and augmentation without autologous grafting or conventional synthetic materials. Two critical challenges have been addressed in a number of recent studies: a biology challenge of angiogenesis and an engineering challenge of shape maintenance. These two challenges are inter-related and are effectively addressed by integrated bioengineering strategies. Recently, several integrated bioengineering strategies have been applied to improve bioengineered adipose tissue grafts, including internalized microchannels, delivery of angiogenic growth factors, tailored biomaterials and transplantation of precursor cells with continuing differentiation potential. Bioengineered soft tissue grafts are only clinically meaningful if they are vascularized, maintain shape and dimensions, and remodel with the host. Ongoing studies have begun to demonstrate the feasibility towards an ultimate goal to generate vascularized soft tissue grafts that maintain anatomically desirable shape and dimensions.
authors.affiliation: Tissue Engineering and Regenerative Medicine Laboratory, Department of Biomedical Engineering, Columbia University Medical Center, College of Dental Medicine, New York, NY 10032, USA.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Stosich
authors.forename: Eduardo K
authors.initials: EK
authors.lastname: Moioli
authors.forename: June K
authors.initials: JK
authors.lastname: Wu
authors.forename: Chang Hun
authors.initials: CH
authors.lastname: Lee
authors.forename: Christine
authors.initials: C
authors.lastname: Rohde
authors.forename: Azizeh Mitra
authors.initials: AM
authors.lastname: Yoursef
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Ascherman
authors.forename: Robert
authors.initials: R
authors.lastname: Diraddo
authors.forename: Nicholas W
authors.initials: NW
authors.lastname: Marion
authors.forename: Jeremy J
authors.initials: JJ
authors.lastname: Mao
mesh_terms: D000273:Adipose Tissue / Q000098:blood supply / Q000637:transplantation; D001698:Biomedical Engineering; D016222:Fibroblast Growth Factor 2 / Q000627:therapeutic use; D006801:Humans; D020100:Hydrogels / Q000627:therapeutic use; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods; D059630:Mesenchymal Stem Cells / Q000502:physiology; D011092:Polyethylene Glycols / Q000627:therapeutic use; D019651:Plastic Surgery Procedures / Q000379:methods; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds; D014182:Transplantation, Autologous
chemical_list: D020100:Hydrogels; D016222:Fibroblast Growth Factor 2; D011092:Polyethylene Glycols