Cadmium induced testicular pathophysiology: prophylactic role of taurine.
The aim of the present study was to investigate the role of taurine against cadmium induced testicular pathophysiology. Cadmium (in the form of Cadmium chloride, CdCl(2)) administration at a dose of 4 mg/kg body weight for 6 days significantly decreased testicular Delta(5)-3beta-HSD and 17beta-HSD activities along with the reduction in the plasma testosterone level. In addition, reductions in testicular sperm count as well as loss in sperm motility were also observed in Cd-intoxication. Cd increased the intracellular concentration of reactive oxygen species and testicular Cd accumulation. Besides, increased levels of lipid peroxidation, protein carbonylation, glutathione disulfide and DNA fragmentation as well as decreased levels of the activities of the antioxidant enzymes, total thiols and reduced glutathione were also found to be associated with this toxicity. Taurine pretreatment at a dose of 100 mg/kg body weight for 5 days, on the other hand, could prevent all the Cd-induced testicular pathophysiology and oxidative insult related studied parameters. Taurine treatment, in addition also increased the in vivo ferric reducing antioxidant power linearly up to a dose of 100 mg/kg body weight. Histological examination of testicular sections from experimental animals supported these results. The effect of a well established antioxidant, vitamin C has been included in the study as a positive control. Combining all, data suggest that being an antioxidant, taurine plays a beneficial role against Cd-induced adverse effects on the male reproductive system.
Manna
Prasenjit
P
Department of Chemistry, Bose Institute, 93/1, Acharya Prafulla Chandra Road, Kolkata, West Bengal 700009, India.
Sinha
Mahua
M
Sil
Parames C
PC
D000818:Animals; D019256:Cadmium Chloride / Q000493:pharmacokinetics / Q000633:toxicity*; D053938:DNA Fragmentation / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D017382:Reactive Oxygen Species / Q000378:metabolism; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013654:Taurine / Q000494:pharmacology*; D013737:Testis / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology
D017382:Reactive Oxygen Species; D013654:Taurine; D019256:Cadmium Chloride