[Effect of kangquan recipe on basic fibroblast growth factor of prostate tissue in rats].
OBJECTIVE
To investigate the effect of Kangquan Recipe (KQR) on basic fibroblast growth factor (bFGF) in prostatic tissue of rats.


METHODS
Benign prostatic hyperplasia model rat was established by injecting testosterone after castration. After being administered with KQR by gastrogavage for 30 days, the model rats were killed and their abdominal lobe prostate glands were taken for determining the protein and mRNA expressions of bFGF using immunohistochemical method and RT-polymerase chain reaction (RT-PCR) respectively.


RESULTS
The expressions of bFGF and bFGF mRNA were significantly lower in the model rats being treated with high or medium dose of KQR than those in the untreated model rats (P < 0.05 or P < 0.01), but these indexes were insignificantly different between the model rats treated with low dose of KQR and untreated model rats (P > 0.05).


CONCLUSIONS
KQR can effectively decrease the expression of bFGF in prostatic tissue of experimental benign prostate hyperplasia model rats.
Huang
Yuan-peng
YP
Zhongshan Hospital Affiliated to Xiamen University, Fujian 361004. huangyp998@sina.com
Du
Jian
J
Hong
Zhen-feng
ZF
D000818:Animals; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D016222:Fibroblast Growth Factor 2 / Q000235:genetics / Q000378:metabolism*; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D008297:Male; D011467:Prostate / Q000187:drug effects* / Q000378:metabolism; D011470:Prostatic Hyperplasia / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D004365:Drugs, Chinese Herbal; C533454:kangquan; D016222:Fibroblast Growth Factor 2