Feasibility of allogeneic hematopoietic stem cell transplantation for follicular lymphoma undergoing transformation to diffuse large B-cell lymphoma.
The transformation of follicular lymphoma (FL) to high-grade histology occurs in up to 70% of FL patients. Studies reporting outcomes of transformed FL patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) are scant. Eight FL patients with histologically confirmed transformation to diffuse large B-cell lymphoma underwent HSCT at our institution. The median age was 56 years (range 44-63 years). Median follow-up is 60 months. Progression free survival and overall survival at 4-years for patients undergoing allogeneic HSCT is 56% and 66%, respectively. Four patients developed grade II-IV acute GVHD, whereas four patients had extensive chronic GVHD. Day 100 and overall non-relapse mortality rate was 12.5% and 25%, respectively. Allogeneic HSCT appears feasible in patients with transformed FL and is associated with acceptable treatment-related mortality and low relapse rates.
Hamadani
Mehdi
M
Department of Hematology and Oncology and Bone Marrow Transplantation, The Ohio State University, Columbus, Ohio 43210, USA. mehdi.hamadani@gmail.com
Awan
Farrukh T
FT
Elder
Patrick
P
Lin
Thomas S
TS
Porcu
Pierluigi
P
Benson
Don M
DM
Blum
Kristie A
KA
Devine
Steven M
SM
D000328:Adult; D002471:Cell Transformation, Neoplastic; D005240:Feasibility Studies; D005260:Female; D006086:Graft vs Host Disease; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D008224:Lymphoma, Follicular / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000209:etiology / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D016879:Salvage Therapy; D016019:Survival Analysis; D019172:Transplantation Conditioning / Q000379:methods; D014184:Transplantation, Homologous