[Physico-chemical stability and sterility of non-opioid analgesics in solution].
OBJECTIVE
The combination of non-opioid analgesic drugs (P: paracetamol, K: ketoprofen and N: nefopam) is currently recommended for postoperative pain control. In practice, these analgesics are often administered in the same solution. We investigated the chemical stability and sterility of three mixtures of analgesics (P+K, P+N and K+N).


METHODS
For each mixture, concentrations of active principles were measured using high-performance liquid chromatography over 24 hours. These mixtures were cultured for microbiological colonization.


RESULTS
Our study demonstrated chemical and bacteriologic stability of these three mixtures over a 24-hour period. The results allow the use of P+K, P+N and K+N in the same ready to use solution.
Troïtzky
A
A
Département d'anesthésie-réanimation, hôpital Jean-Bernard, 2, rue de la Milétrie, BP 577, 86021 Poitiers cedex, France. annetroitzky@aol.com
Tirault
M
M
Lefeuvre
S
S
Lepage
B
B
Debaene
B
B
D000082:Acetaminophen / Q000032:analysis / Q000737:chemistry / Q000528:radiation effects; D018712:Analgesics, Non-Narcotic / Q000032:analysis / Q000737:chemistry / Q000528:radiation effects; D055598:Chemical Phenomena; D002851:Chromatography, High Pressure Liquid; D004338:Drug Combinations; D004340:Drug Contamination; D004355:Drug Stability; D004356:Drug Storage / Q000379:methods; D007660:Ketoprofen / Q000032:analysis / Q000737:chemistry / Q000528:radiation effects; D008027:Light; D009340:Nefopam / Q000032:analysis / Q000737:chemistry / Q000528:radiation effects; D012996:Solutions
D018712:Analgesics, Non-Narcotic; D004338:Drug Combinations; D012996:Solutions; D000082:Acetaminophen; D009340:Nefopam; D007660:Ketoprofen