[Action and resistance mechanisms of capreomycin: a functional genomic perspective].
Last two decades have witnessed the resurging of tuberculosis (TB) and multi-drug resistant TB, even the extensive drug resistant TB. It is urgent to develop novel drug to combat the increasingly worsen TB. Capreomycin is an ideal second-line TB drug. It is also recognized as an attractive template to develop more peptide antibiotics. In this review, the biosynthesis gene cluster of capreomycin, the action mechanism unveiled by transcriptome and novel resistance rational are summarized from the recent functional genomic investigation.
Liu
Xue-Mei
XM
Institute of Modern Biopharmaceuticals, School of Life Science, Southwest University, Chongqing 400715, China.
Xie
Jian-Ping
JP
D000904:Antibiotics, Antitubercular / Q000737:chemistry / Q000494:pharmacology; D002207:Capreomycin / Q000737:chemistry / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects*; D005798:Genes, Bacterial; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000235:genetics; D016366:Open Reading Frames; D000080882:Ribosomal Protein L10; D012269:Ribosomal Proteins / Q000378:metabolism; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy
D000904:Antibiotics, Antitubercular; D012269:Ribosomal Proteins; D002207:Capreomycin