Size regulation of ss-RNA viruses.
While a monodisperse size distribution is common within one kind of spherical virus, the size of viral shells varies from one type of virus to another. In this article, we investigate the physical mechanisms underlying the size selection among spherical viruses. In particular, we study the effect of genome length and genome and protein concentrations on the size of spherical viral capsids in the absence of spontaneous curvature and bending energy. We find that the coat proteins could well adjust the size of the shell to the size of their genome, which in turn depends on the number of charges on it. Furthermore, we find that different stoichiometric mixtures of proteins and genome can produce virus particles of various sizes, consistent with in vitro experiments.
Zandi
Roya
R
Department of Physics and Astronomy, University of California, Riverside, California, USA.
van der Schoot
Paul
P
D000465:Algorithms; D036022:Capsid Proteins / Q000737:chemistry / Q000378:metabolism; D016679:Genome, Viral / Q000502:physiology; D008962:Models, Theoretical; D012328:RNA Viruses / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*; D055672:Static Electricity; D018406:Virus Physiological Phenomena / Q000235:genetics*
D036022:Capsid Proteins