title: Antibacterial activity and spectral studies of trivalent chromium, manganese, iron macrocyclic complexes derived from oxalyldihydrazide and glyoxal.
abstract: A new series of complexes is synthesized by template condensation of oxalyldihydrazide and glyoxal in methanolic medium in the presence of trivalent chromium, manganese and iron salts forming complexes of the type: [M(C(8)H(8)N(8)O(4))X]X(2) where M = Cr(III), Mn(III), Fe(III) and X = Cl(-1), NO(-1)(3), CH(3)COO(-1). The complexes have been characterized with the help of elemental analyses, conductance measurements, magnetic susceptibility measurements, electronic, NMR, infrared and far infrared spectral studies. On the basis of these studies, a five coordinate square pyramidal geometry for these complexes has been proposed. The biological activities of the metal complexes were tested in vitro against a number of pathogenic bacteria and some of the complexes exhibited remarkable antibacterial activities.
authors.affiliation: Department of Chemistry, National Institute of Technology, Kurukshetra, Haryana, 136 119, India. dpsinghchem@yahoo.co.in
authors.forename: D P
authors.initials: DP
authors.lastname: Singh
authors.forename: Ramesh
authors.initials: R
authors.lastname: Kumar
authors.forename: Jitender
authors.initials: J
authors.lastname: Singh
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002412:Cations; D002857:Chromium; D004553:Electric Conductivity; D006037:Glyoxal / Q000737:chemistry*; D007501:Iron; D047028:Macrocyclic Compounds / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008345:Manganese; D008670:Metals / Q000737:chemistry*; D000432:Methanol / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010070:Oxalates / Q000737:chemistry*; D013055:Spectrophotometry, Infrared
chemical_list: D000900:Anti-Bacterial Agents; D002412:Cations; D047028:Macrocyclic Compounds; D008670:Metals; D009942:Organometallic Compounds; D010070:Oxalates; D002857:Chromium; D008345:Manganese; D006037:Glyoxal; C014724:oxalic acid hydrazide; D007501:Iron; D000432:Methanol