Two cases of Cushing's syndrome due to overuse of topical steroid in the diaper area.
Topical use of corticosteroids may cause immunosuppression and iatrogenic Cushing's syndrome via hypothalamic-pituitary-adrenal axis. We report two cases with iatrogenic Cushing's syndrome with different clinical outcomes due to abuse of same potent topical steroid clobetasol propionate. One of them died because of fatal disseminated cytomegalovirus infection. The other patient recovered completely. Physicians and parents should be informed about the adverse effects of such potent topical corticosteroids and physicians should prescribe less potent agents, especially during infancy.
Semiz
Serap
S
Department of Pediatric Endocrinology, Faculty of Medicine, Pamukkale University, Denizli, Turkey. drssemiz@yahoo.com
Balci
Yasemin Işik
YI
Ergin
Seniz
S
Candemir
Maşallah
M
Polat
Aziz
A
D000287:Administration, Topical; D002179:Candidiasis, Cutaneous / Q000150:complications; D002990:Clobetasol / Q000008:administration & dosage / Q000009:adverse effects*; D003480:Cushing Syndrome / Q000139:chemically induced*; D003586:Cytomegalovirus Infections / Q000150:complications; D003963:Diaper Rash / Q000150:complications / Q000188:drug therapy*; D017809:Fatal Outcome; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007223:Infant
D005938:Glucocorticoids; D002990:Clobetasol