Impact of intravenous loop diuretics on outcomes of patients hospitalized with acute decompensated heart failure: insights from the ADHERE registry.
The optimal use of diuretics in decompensated heart failure remains uncertain. We analyzed data from the ADHERE registry to look at the impact of diuretic dosing. 62,866 patients receiving <160 mg and 19,674 patients > or =160 mg of furosemide were analyzed. The patients receiving the lower doses had a lower risk for in-hospital mortality, ICU stay, prolonged hospitalization, or adverse renal effects. These findings suggest that future studies should evaluate strategies for minimizing exposure to high doses of diuretics.
Peacock
W Franklin
WF
Department of Emergency Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Costanzo
Maria Rosa
MR
De Marco
Teresa
T
Lopatin
Margarita
M
Wynne
Janet
J
Mills
Roger M
RM
Emerman
Charles L
CL
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005665:Furosemide / Q000008:administration & dosage* / Q000009:adverse effects; D006333:Heart Failure / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D007262:Infusions, Intravenous; D007668:Kidney / Q000187:drug effects*; D007677:Kidney Function Tests; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D012042:Registries; D012189:Retrospective Studies; D049994:Sodium Potassium Chloride Symporter Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D014481:United States / Q000453:epidemiology
D049994:Sodium Potassium Chloride Symporter Inhibitors; D005665:Furosemide