title: Genotypic versus phenotypic characterization, with respect to beta-lactam susceptibility, of Haemophilus influenzae isolates exhibiting decreased susceptibility to beta-lactam resistance markers.
abstract: Among 165 Spanish Haemophilus influenzae isolates with mutations in the ftsI gene (ftsI(+)) (2005 to 2007), 73% were beta-lactamase negative and 26.7% were positive. The proportion of beta-lactamase-negative isolates to beta-lactamase-positive isolates was 2:1 to 4:1 in general, versus 1:3 in pediatric hospitals. Among 44 beta-lactamase-positive strains, 8 strains produced ROB-1 (5 from the pediatric hospital). beta-Lactamase-positive ftsI(+) strains were phylogenetically closer than were beta-lactamase-negative strains.
authors.affiliation: Microbiology Department, School of Medicine, Univ Complutense, Madrid, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Sevillano
authors.forename: María-José
authors.initials: MJ
authors.lastname: Giménez
authors.forename: Emilia
authors.initials: E
authors.lastname: Cercenado
authors.forename: Fabio
authors.initials: F
authors.lastname: Cafini
authors.forename: Amadeo
authors.initials: A
authors.lastname: Gené
authors.forename: Luis
authors.initials: L
authors.lastname: Alou
authors.forename: Francesc
authors.initials: F
authors.lastname: Marco
authors.forename: Luis
authors.initials: L
authors.lastname: Martínez-Martínez
authors.forename: Pilar
authors.initials: P
authors.lastname: Coronel
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Aguilar
mesh_terms: D001426:Bacterial Proteins / Q000145:classification / Q000235:genetics; D005838:Genotype; D006193:Haemophilus influenzae / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008826:Microbial Sensitivity Tests; D009154:Mutation; D010641:Phenotype; D018440:beta-Lactam Resistance / Q000235:genetics*; D047090:beta-Lactams / Q000494:pharmacology
chemical_list: D001426:Bacterial Proteins; D047090:beta-Lactams