title: Impact of intravenous loop diuretics on outcomes of patients hospitalized with acute decompensated heart failure: insights from the ADHERE registry.
abstract: The optimal use of diuretics in decompensated heart failure remains uncertain. We analyzed data from the ADHERE registry to look at the impact of diuretic dosing. 62,866 patients receiving <160 mg and 19,674 patients > or =160 mg of furosemide were analyzed. The patients receiving the lower doses had a lower risk for in-hospital mortality, ICU stay, prolonged hospitalization, or adverse renal effects. These findings suggest that future studies should evaluate strategies for minimizing exposure to high doses of diuretics.
authors.affiliation: Department of Emergency Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio, USA.
authors.forename: W Franklin
authors.initials: WF
authors.lastname: Peacock
authors.forename: Maria Rosa
authors.initials: MR
authors.lastname: Costanzo
authors.forename: Teresa
authors.initials: T
authors.lastname: De Marco
authors.forename: Margarita
authors.initials: M
authors.lastname: Lopatin
authors.forename: Janet
authors.initials: J
authors.lastname: Wynne
authors.forename: Roger M
authors.initials: RM
authors.lastname: Mills
authors.forename: Charles L
authors.initials: CL
authors.lastname: Emerman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005665:Furosemide / Q000008:administration & dosage* / Q000009:adverse effects; D006333:Heart Failure / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D007262:Infusions, Intravenous; D007668:Kidney / Q000187:drug effects*; D007677:Kidney Function Tests; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D012042:Registries; D012189:Retrospective Studies; D049994:Sodium Potassium Chloride Symporter Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D014481:United States / Q000453:epidemiology
chemical_list: D049994:Sodium Potassium Chloride Symporter Inhibitors; D005665:Furosemide