title: Lipid Lowering Activity of Anthocephalus indicus Root in Hyperlipidemic Rats.
abstract: The lipid lowering activity of Anthocephalus indicus (family Rubiaceae; Hindi name Kadamba) root extract has been studied in triton WR-1339 induced hyperlipidemia in rats. In this model, feeding with root extract (500 mg kg(-1) b.w.) lowered plasma lipids and reactivated post-heparin lipolytic activity in hyperlipidemic rats. Furthermore, the root extract (50-500 μM) inhibited the generation of superoxide anions and hydroxyl radicals, in both enzymic and non-enzymic systems, in vitro. The results of the present study demonstrated both lipid lowering and antioxidant activities in root extract of A. indicus, which could help prevention of hyperlipidemia and related diseases.
authors.affiliation: Department of Biochemistry, Era's Lucknow Medical College & Hospital, Lucknow-226003, Division of Biochemistry, Central Drug Research Institute, Lucknow-226001 and Department of Biochemistry, King George's Medical University, Lucknow-226003, India.
authors.forename: Vishnu
authors.initials: V
authors.lastname: Kumar
authors.forename: Mohammad Mubin
authors.initials: MM
authors.lastname: Khan
authors.forename: Ashok Kumar
authors.initials: AK
authors.lastname: Khanna
authors.forename: Ranjana
authors.initials: R
authors.lastname: Singh
authors.forename: Sushma
authors.initials: S
authors.lastname: Singh
authors.forename: Ramesh
authors.initials: R
authors.lastname: Chander
authors.forename: Farzana
authors.initials: F
authors.lastname: Mahdi
authors.forename: Abbas Ali
authors.initials: AA
authors.lastname: Mahdi
authors.forename: Jitendra Kumar
authors.initials: JK
authors.lastname: Saxena
authors.forename: Raj Kumar
authors.initials: RK
authors.lastname: Singh