Emerging functional roles of cathepsin E.
Cathepsin E is an intracellular aspartic protease of the endolysosomal pathway. It has been implicated in several physiological and pathological processes however, its exact functional role is yet to be elucidated. The present review gives an account of the major physiological functions that are associated to cathepsin E by various research groups and highlights the conditions developed in cathepsin E deficiency or the conditions where overexpression of cathepsin E is observed.
Zaidi
Nousheen
N
Medical and Natural Sciences Research Centre, University of Tubingen, Ob dem Himmelreich 7, 72074 Tubingen, Germany; Interfacultary Institute of Biochemistry, University of Tubingen, Germany. Electronic address: nousheen.zaidi@gmail.com.
Hermann
Clemens
C
Medical and Natural Sciences Research Centre, University of Tubingen, Ob dem Himmelreich 7, 72074 Tubingen, Germany; Interfacultary Institute of Biochemistry, University of Tubingen, Germany.
Herrmann
Timo
T
Medical and Natural Sciences Research Centre, University of Tubingen, Ob dem Himmelreich 7, 72074 Tubingen, Germany; Interfacultary Institute of Biochemistry, University of Tubingen, Germany.
Kalbacher
Hubert
H
Medical and Natural Sciences Research Centre, University of Tubingen, Ob dem Himmelreich 7, 72074 Tubingen, Germany; Interfacultary Institute of Biochemistry, University of Tubingen, Germany.
D000375:Aging / Q000378:metabolism*; D000818:Animals; D020059:Cathepsin E / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D000949:Histocompatibility Antigens Class II / Q000378:metabolism*; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D009369:Neoplasms / Q000201:enzymology*
D000949:Histocompatibility Antigens Class II; D020059:Cathepsin E