title: Structural basis for exon recognition by a group II intron.
abstract: Free group II introns are infectious retroelements that can bind and insert themselves into RNA and DNA molecules via reverse splicing. Here we report the 3.4-A crystal structure of a complex between an oligonucleotide target substrate and a group IIC intron, as well as the refined free intron structure. The structure of the complex reveals the conformation of motifs involved in exon recognition by group II introns.
authors.affiliation: Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, Connecticut 06520, USA.
authors.forename: Navtej
authors.initials: N
authors.lastname: Toor
authors.forename: Kanagalaghatta
authors.initials: K
authors.lastname: Rajashankar
authors.forename: Kevin S
authors.initials: KS
authors.lastname: Keating
authors.forename: Anna Marie
authors.initials: AM
authors.lastname: Pyle
mesh_terms: D018360:Crystallography, X-Ray; D005091:Exons; D007438:Introns; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation