Candida tropicalis arthritis in a patient with acute leukemia.
Candida arthritis in patient with hematological malignancy is rare. A case of Candida tropicalis arthritis of knee occurred in a patient with acute monocytic leukemia was reported during the recovery phase of post chemotherapy myelosuppression and agranulocytosis. The patient was diagnosed as Candida tropicalis arthritis of knee according to the Candida tropicalis isolated from the synovial fluid. Itraconazole and amphotericin B were intravenously injected for therapy for 4 - 5 weeks based on the susceptibility test in vitro, which showed better efficacy. But the arthritis relapsed at 4 - 6 weeks after the drug withdrawal. The curative effect was found in patient after treatment with fluconazole injection and articular cavity douching with amphotericin B for 8 weeks. In conclusion, although Candida arthritis in patient with hematological malignancy is rare, it still occurred in the patient with hypoimmunity. The treatment emphasis showed be placed on the full dosage and full treatment course of antifungal agent.
Hu
Xiao-Rong
XR
Bone Marrow Transplantation Center, The First Hospital, Zhejiang University Midical College, Hangzhou 310003, Zhejiang Province, China.
He
Jing-Song
JS
Ye
Xiu-Jin
XJ
Zheng
Wei-Yan
WY
Wu
Wen-Jun
WJ
Lin
Mao-Fang
MF
D000935:Antifungal Agents / Q000627:therapeutic use; D001170:Arthritis, Infectious / Q000188:drug therapy / Q000382:microbiology*; D041022:Candida tropicalis / Q000302:isolation & purification; D002177:Candidiasis / Q000188:drug therapy; D005260:Female; D006801:Humans; D007938:Leukemia / Q000382:microbiology*; D008875:Middle Aged
D000935:Antifungal Agents