title: Therapeutic effect of traditional Chinese medicine on coagulation disorder and accompanying intractable jaundice in hepatitis B virus-related liver cirrhosis patients.
abstract: OBJECTIVE
  To observe the therapeutic effects of new traditional Chinese medicine (TCM) therapy on coagulation disorder and accompanying intractable jaundice in HBV-related liver cirrhosis patients.
  
  
  METHODS
  Using stratified random sampling according to fibrinogen (Fib) levels, 145 liver cirrhosis patients due to hepatitis B complicated by coagulation disorder were treated. Of them, 70 in research group were treated with TCM by "nourishing yin, cooling blood and invigorating blood circulation" and Western medicine, 75 in control group were treated with conventional Western medicine. The indexes of liver function, coagulation function and bleeding events were observed and compared.
  
  
  RESULTS
  The prothrombin time (PT) was shorter and the fibrinogen (Fib) level was higher in the research group than in the control group (Fib = 1.6-2.0 g/L, 1.1-1.5 g/L, and < or = 1.0 g/L). The total bilirubin (TBIL) level was significantly lower in the research group than in the control group, except for the subgroup of FIB < or = 1.0 g/L.
  
  
  CONCLUSIONS
  TCM therapy can improve coagulation fuction and decrease TBIL.
authors.affiliation: Department of TCM, The Third Affiliated Hospital of Sun Yat-Sen University, Guangdong Province, China.
authors.forename: Yang-Mei
authors.initials: YM
authors.lastname: Li
authors.forename: Hong-Zhi
authors.initials: HZ
authors.lastname: Yang
authors.forename: Wei-Bing
authors.initials: WB
authors.lastname: Guan
authors.forename: Qian-Shan
authors.initials: QS
authors.lastname: Ke
authors.forename: Min
authors.initials: M
authors.lastname: Dai
authors.forename: He-Ping
authors.initials: HP
authors.lastname: Xie
authors.forename: Shi-Jun
authors.initials: SJ
authors.lastname: Zhang
mesh_terms: D000328:Adult; D001663:Bilirubin / Q000378:metabolism; D001775:Blood Circulation / Q000502:physiology; D001777:Blood Coagulation / Q000502:physiology; D001778:Blood Coagulation Disorders / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006509:Hepatitis B / Q000150:complications*; D006515:Hepatitis B virus; D006801:Humans; D007565:Jaundice / Q000209:etiology / Q000378:metabolism / Q000628:therapy*; D008103:Liver Cirrhosis / Q000150:complications* / Q000821:virology*; D008297:Male; D008516:Medicine, Chinese Traditional / Q000379:methods*; D008875:Middle Aged; D011517:Prothrombin Time; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D005340:Fibrinogen; D001663:Bilirubin