title: Effective and safe immunizations with live-attenuated vaccines for children after living donor liver transplantation.
abstract: Immunizations using live-attenuated vaccines are not recommended for post-liver transplant children due to its theoretical risks. However, they will encounter vaccine-preventable viral diseases upon returning to real-life situations. We performed a total of 70 immunizations with four individual live-attenuated vaccines to 18 pediatric post-living donor liver transplant (LDLT) recipients who fulfilled a clinical criteria including humoral and cell-mediated immunity. The seroconversion rates at the first dose for measles (strain AIK-C), rubella (strain TO-336), varicella (strain Oka), and mumps (strains Hoshino) were 100% (15/15), 100% (15/15), 82% (9/11), and 82% (9/11), respectively. During observed period (-5 years 11 months), a few cases with waning immunity (antibodies were once produced but the levels fell over time) were seen except after rubella immunization. Clinical diseases after seroconversion or definite serious adverse effects due to immunization were not observed. Immunizations using selected live-attenuated vaccines were safe and effective for post-LDLT children who were not severely immunosuppressed.
authors.affiliation: Department of Pediatrics, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan. m.shinjo@z2.keio.jp
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Shinjoh
authors.forename: Isao
authors.initials: I
authors.lastname: Miyairi
authors.forename: Ken
authors.initials: K
authors.lastname: Hoshino
authors.forename: Takao
authors.initials: T
authors.lastname: Takahashi
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Nakayama
mesh_terms: D000917:Antibody Formation / Q000187:drug effects / Q000276:immunology; D019433:Chickenpox Vaccine / Q000009:adverse effects / Q000276:immunology; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects / Q000276:immunology; D007117:Immunization, Secondary; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D007223:Infant; D016031:Liver Transplantation / Q000276:immunology*; D019520:Living Donors; D008297:Male; D022542:Measles-Mumps-Rubella Vaccine / Q000009:adverse effects / Q000276:immunology; D014613:Vaccines, Attenuated / Q000009:adverse effects* / Q000276:immunology*
chemical_list: D019433:Chickenpox Vaccine; D007166:Immunosuppressive Agents; D022542:Measles-Mumps-Rubella Vaccine; D014613:Vaccines, Attenuated