title: Postoperative gait deterioration after bilateral subthalamic nucleus stimulation in Parkinson's disease.
abstract: Deep brain stimulation of the subthalamic nuclei (STN) is a good therapeutic option to reduce dyskinesias and improve appendicular motor signs in well-selected patients with advanced Parkinson's disease (PD). Concerns about long-term adverse effects play an increasingly role in the decision whether or not to refer patients for this treatment. Worsening of gait as a consequence of STN stimulation for PD has been described, but may be under-recognized in clinical practice. The aim of this study was to evaluate the effects of STN stimulation on gait relative to global outcome in a group of consecutively operated patients. For this purpose, we used a standardized patient questionnaire that asked about global outcome and specific effects on gait, as experienced both 6 months postoperatively and currently (at the time of completing the questionnaire; mean: 2.7 +/- 1.1 years). A delayed worsening of gait after bilateral STN stimulation was experienced by a considerable proportion of patients (42% of subjects, for gait in the OFF phase), and this was apparently relatively "selective" because their global outcome scores continued to be improved. These findings highlight the presence of a hitherto poorly recognized long-term complication of bilateral STN stimulation. Further systematic studies are required to pinpoint the clinical and surgical determinants of this late gait deterioration.
authors.affiliation: Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
authors.forename: Bart F L
authors.initials: BF
authors.lastname: van Nuenen
authors.forename: Rianne A J
authors.initials: RA
authors.lastname: Esselink
authors.forename: Marten
authors.initials: M
authors.lastname: Munneke
authors.forename: Johhannes D
authors.initials: JD
authors.lastname: Speelman
authors.forename: Teus
authors.initials: T
authors.lastname: van Laar
authors.forename: Bastiaan R
authors.initials: BR
authors.lastname: Bloem
mesh_terms: D046690:Deep Brain Stimulation / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D020233:Gait Disorders, Neurologic / Q000209:etiology*; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000628:therapy; D011184:Postoperative Period; D012189:Retrospective Studies; D020531:Subthalamic Nucleus / Q000502:physiology*; D011795:Surveys and Questionnaires