title: Weight loss after laparoscopic adjustable gastric banding is not caused by altered gastric emptying.
abstract: BACKGROUND
  In order to know the role of gastric emptying in the mechanism of weight loss and early satiety after a restrictive surgical procedure for treatment of morbid obesity, a consecutive series of patients were scintigraphically investigated before and after laparoscopic adjustable gastric banding.
  
  
  METHODS
  Sixteen patients undergoing laparoscopic adjustable gastric banding underwent preoperatively, and at 6 months postoperatively, a gastric emptying study (solid meal and single isotope). Esophageal retention time, lag phase, peak activity time, gastric emptying rate, fundus emptying rate, and weight loss were recorded. Upper GI symptom assessment was carried out by using a standardized questionnaire. Gastric emptying parameters were correlated with the upper GI symptoms.
  
  
  RESULTS
  Gastric band placement showed no significant influence on postoperative gastric emptying rate [median % (interquartile range): 42 (23.3-59) preoperatively vs 38 (31-71) postoperatively and fundus emptying rate: 59(37-91) preoperatively vs 70 (53-89) postoperatively]; however, an increase in early satiety was found. Neither gastric emptying rate nor fundus emptying rate showed a relation with early satiety or weight loss. Furthermore, no correlation was found between early satiety and lag phase, esophageal retention time, start of activity, and peak activity time in proximal stomach.
  
  
  CONCLUSIONS
  Laparoscopic adjustable gastric banding seems not to affect gastric emptying. Neither a relation between postoperative gastric emptying rate and weight loss nor between early satiety and weight loss was found. Therefore, it is unlikely that gastric emptying plays a role in the mechanism of weight loss following laparoscopic adjustable gastric banding.
authors.affiliation: Department of Surgery, University Medical Center, Maastricht, The Netherlands. jr.dejong@mumc.nl
authors.forename: J R
authors.initials: JR
authors.lastname: de Jong
authors.forename: B
authors.initials: B
authors.lastname: van Ramshorst
authors.forename: H G
authors.initials: HG
authors.lastname: Gooszen
authors.forename: A J P M
authors.initials: AJ
authors.lastname: Smout
authors.forename: M M C
authors.initials: MM
authors.lastname: Tiel-Van Buul
mesh_terms: D000328:Adult; D015331:Cohort Studies; D004947:Esophagus / Q000000981:diagnostic imaging / Q000503:physiopathology; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D005748:Gastric Fundus / Q000000981:diagnostic imaging / Q000503:physiopathology; D015391:Gastroplasty; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery*; D011877:Radionuclide Imaging; D016896:Treatment Outcome; D015431:Weight Loss / Q000502:physiology*