title: Comparison between intravenous and oral postoperative adjuvant immunochemotherapy in patients with stage II colorectal cancer.
abstract: The present study was designed to retrospectively examine the efficacy of postoperative adjuvant chemotherapy in 107 patients with stage II primary colorectal cancer who underwent curative resection. The chemotherapy regimen was intravenous 5FU/LV in 30 patients (FL-IV group) and oral UFT/PSK in 77 patients (oral group). There were no significant differences between the FL-IV and the oral group with respect to the 3-year relapse-free survival rate, 5-year relapse-free survival rate, and 5-year overall survival rate, which were 82.4 vs. 83.0% (p=0.8546), 78.8 vs. 80.0% (p=0.756), and 81.6 vs. 92.8% (p=0.1609), respectively. Grade 3 adverse events that occurred in the FL-IV group were leukopenia in one patient (3.3%), nausea/vomiting in two (6.6%), anorexia in two (6.6%), diarrhea in one (3.3%), and fatigue in one (3.3%). No grade 3 or 4 adverse events were observed in the oral group. These results suggest that the oral regimen achieved equivalent efficacy to the FL-IV regimen in patients with stage II colorectal cancer, while improving their postoperative quality of life.
authors.affiliation: Tokai University Oiso Hospital, Department of Surgery, Oiso, Kanagawa, Japan. isaoito@is.icc.u-tokai.ac.jp
authors.forename: Isao
authors.initials: I
authors.lastname: Ito
authors.forename: Masaya
authors.initials: M
authors.lastname: Mukai
authors.forename: Hiromi
authors.initials: H
authors.lastname: Ninomiya
authors.forename: Kyoko
authors.initials: K
authors.lastname: Kishima
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Tsuchiya
authors.forename: Takayuki
authors.initials: T
authors.lastname: Tajima
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Oida
authors.forename: Masato
authors.initials: M
authors.lastname: Nakamura
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Makuuchi
mesh_terms: D000284:Administration, Oral; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000009:adverse effects*; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D018572:Disease-Free Survival; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007167:Immunotherapy / Q000009:adverse effects; D007262:Infusions, Intravenous; D053208:Kaplan-Meier Estimate; D002955:Leucovorin / Q000008:administration & dosage / Q000009:adverse effects; D009367:Neoplasm Staging; D011788:Quality of Life; D012189:Retrospective Studies
chemical_list: D002955:Leucovorin; D005472:Fluorouracil