A scaffold makes the switch.
Protein kinase cascades are a reoccurring feature of signal transduction pathways. Recent investigations have focused on how kinase-scaffolding proteins help to convert a graded stimulus into a switch-like or binary response. New findings reveal that the graded-to-binary conversion can be turned on or off, depending on the location of the scaffold within the cell.
Dohlman
Henrik G
HG
Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599-7260, USA. henrik_dohlman@med.unc.edu
D000818:Animals; D006801:Humans; D020935:MAP Kinase Signaling System / Q000502:physiology*; D020929:Mitogen-Activated Protein Kinase Kinases / Q000378:metabolism*; D008954:Models, Biological; D011494:Protein Kinases / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000502:physiology
D011494:Protein Kinases; D020929:Mitogen-Activated Protein Kinase Kinases