title: STRING 8--a global view on proteins and their functional interactions in 630 organisms.
abstract: Functional partnerships between proteins are at the core of complex cellular phenotypes, and the networks formed by interacting proteins provide researchers with crucial scaffolds for modeling, data reduction and annotation. STRING is a database and web resource dedicated to protein-protein interactions, including both physical and functional interactions. It weights and integrates information from numerous sources, including experimental repositories, computational prediction methods and public text collections, thus acting as a meta-database that maps all interaction evidence onto a common set of genomes and proteins. The most important new developments in STRING 8 over previous releases include a URL-based programming interface, which can be used to query STRING from other resources, improved interaction prediction via genomic neighborhood in prokaryotes, and the inclusion of protein structures. Version 8.0 of STRING covers about 2.5 million proteins from 630 organisms, providing the most comprehensive view on protein-protein interactions currently available. STRING can be reached at http://string-db.org/.
authors.affiliation: European Molecular Biology Laboratory, Heidelberg, Germany.
authors.forename: Lars J
authors.initials: LJ
authors.lastname: Jensen
authors.forename: Michael
authors.initials: M
authors.lastname: Kuhn
authors.forename: Manuel
authors.initials: M
authors.lastname: Stark
authors.forename: Samuel
authors.initials: S
authors.lastname: Chaffron
authors.forename: Chris
authors.initials: C
authors.lastname: Creevey
authors.forename: Jean
authors.initials: J
authors.lastname: Muller
authors.forename: Tobias
authors.initials: T
authors.lastname: Doerks
authors.forename: Philippe
authors.initials: P
authors.lastname: Julien
authors.forename: Alexander
authors.initials: A
authors.lastname: Roth
authors.forename: Milan
authors.initials: M
authors.lastname: Simonovic
authors.forename: Peer
authors.initials: P
authors.lastname: Bork
authors.forename: Christian
authors.initials: C
authors.lastname: von Mering
mesh_terms: D030562:Databases, Protein; D023281:Genomics; D046912:Multiprotein Complexes / Q000378:metabolism; D025941:Protein Interaction Mapping; D011506:Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D014584:User-Computer Interface
chemical_list: D046912:Multiprotein Complexes; D011506:Proteins