title: [Multicentral randomized controlled clinical trials about treatment of perimenopausal syndrome with electroacupuncture of sanyinjiao (SP 6)].
abstract: OBJECTIVE
  To evaluate the effect of electroacupuncture (EA) of Sanyinjiao (SP 6) on perimenopausal syndrome (PMS).
  
  
  METHODS
  Multicentral randomized controlled trials and single blind test were adopted in the present study. A total of 157 PMS patients were randomly divided into EA group (n=81) and medication group (n=76) . EA (2/100 Hz, 8-10 mA) was applied to bilateral Sanyinjiao (SP 6), 3 times a week and for 3 months (mon). Patients of medication group were treated by oral administration of nylestriol, 2 mg/time, twice a mon for 3 mon. For PMS patients, medroxyprogesterone (6 mg/d, for 10 days) was added from the third mon on after the treatment. The therapeutic effect was evaluated by using "symptoms-signs score scale", and changes of serum estradiol (E2), follicle stimulating hormone (FSH) and luteotrophic hormone (LH) were detected by chemiluminescence immune assay. Kupperman index was determined before and after the treatment.
  
  
  RESULTS
  In comparison with pre-treatment, Kupperman index of EA group decreased significantly (P < 0.01). After the treatment, contents of serum FSH and LH of EA group decreased significantly (P < 0.01), while serum E2 contents of EA and medication groups increased significantly (P < 0. 01). Serum LH and E2 levels of EA group were significantly lower than those of medication group (P < 0.05). No significant differences were found between two groups in Kupperman index, markedly-effective rates and total effective rates (P > 0.05).
  
  
  CONCLUSIONS
  EA of Sanyinjiao (SP 6) is able to regulate serum E2, FSH and LH levels and effectively improve perimenopausal syndrome.
authors.affiliation: Anhui College of Chinese Medicine, Hefei 230038, China. xxh2024@sina.com
authors.forename: Xiao-hong
authors.initials: XH
authors.lastname: Xia
authors.forename: Ling
authors.initials: L
authors.lastname: Hu
authors.forename: Zheng-yu
authors.initials: ZY
authors.lastname: Qin
authors.forename: Jun
authors.initials: J
authors.lastname: Zhou
authors.forename: Li
authors.initials: L
authors.lastname: Meng
authors.forename: Wei-Li
authors.initials: WL
authors.lastname: Li
authors.forename: Li-ying
authors.initials: LY
authors.lastname: Tian
authors.forename: Yi-juan
authors.initials: YJ
authors.lastname: Zhang
mesh_terms: D015671:Electroacupuncture; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D016740:Meridians; D008875:Middle Aged; D047648:Perimenopause / Q000097:blood*
chemical_list: D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone