title: Hemostasis and ageing.
abstract: On March 19, 2008 a Symposium on Pathophysiology of Ageing and Age-Related Diseases was held in Palermo, Italy. The lecture of D. Mari on Hemostasis and ageing is summarized herein. Physiological ageing is associated with increased plasma levels of many proteins of blood coagulation together with fibrinolysis impairment. This may be of great concern in view of the known association between vascular and thromboembolic diseases and ageing. On the other hand, centenarians are characterized by a state of hypercoagulability and possession of several high-risk alleles and well-known atherothrombotic risk markers but this appears to be compatible with longevity and/or health. Parameters considered risk factors for atherosclerotic vascular diseases in young people may lose their biological significance in advanced age and assume a different role.
authors.affiliation: Dipartimento di Scienze Mediche e U.O. di Geriatria, IRCCS, Istituto Auxologico Italiano, Università di Milano, Milano, Italy. daniela.mari@unimi.it
authors.forename: Daniela
authors.initials: D
authors.lastname: Mari
authors.forename: Giulia
authors.initials: G
authors.lastname: Ogliari
authors.forename: Davide
authors.initials: D
authors.lastname: Castaldi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Vitale
authors.forename: Elisa Mariadele
authors.initials: EM
authors.lastname: Bollini
authors.forename: Domenico
authors.initials: D
authors.lastname: Lio