MicroRNA: a new tool for biomedical risk assessment and target identification in human uterine leiomyomas.
MicroRNA (miRNA) expression is tissue specific or cell-type specific. miRNA signatures are useful tools for tumor classification and target gene identification. We and others found that uterine leiomyomas (ULMs) expressed a distinct miRNA signature. In addition, miRNA expression appears to be strongly associated with race and other biomedical factors, such as tumor sizes. Among the most highly dysregulated miRNAs, let-7 miRNAs seem to play a critical role in tumorigenesis of ULMs through negative regulation of some key target oncogenes, including high mobility group 2.
Wei
Jian-Jun
JJ
Department of Pathology, Northwestern University, Chicago, Illinois 60611, USA. jianjun-wei@northwestern.edu
Soteropoulos
Patricia
P
D035843:Biomedical Research / Q000379:methods / Q000639:trends; D055808:Drug Discovery / Q000379:methods / Q000639:trends*; D005006:Ethnicity / Q000235:genetics; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007889:Leiomyoma / Q000175:diagnosis* / Q000208:ethnology / Q000235:genetics / Q000628:therapy*; D035683:MicroRNAs / Q000235:genetics / Q000502:physiology*; D020411:Oligonucleotide Array Sequence Analysis; D011379:Prognosis; D018570:Risk Assessment / Q000379:methods / Q000639:trends; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000208:ethnology / Q000235:genetics / Q000628:therapy*
D035683:MicroRNAs