title: UCbase & miRfunc: a database of ultraconserved sequences and microRNA function.
abstract: Four hundred and eighty-one ultraconserved sequences (UCRs) longer than 200 bases were discovered in the genomes of human, mouse and rat. These are DNA sequences showing 100% identity among the three species. UCRs are frequently located at genomic regions involved in cancer, differentially expressed in human leukemias and carcinomas and in some instances regulated by microRNAs (miRNAs). Here we present UCbase & miRfunc, the first database which provides ultraconserved sequences data and shows miRNA function. Also, it links UCRs and miRNAs with the related human disorders and genomic properties. The current release contains over 2000 sequences from three species (human, mouse and rat). As a web application, UCbase & miRfunc is platform independent and it is accessible at http://microrna.osu.edu/.UCbase4.
authors.affiliation: Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Cristian
authors.initials: C
authors.lastname: Taccioli
authors.forename: Enrica
authors.initials: E
authors.lastname: Fabbri
authors.forename: Rosa
authors.initials: R
authors.lastname: Visone
authors.forename: Stefano
authors.initials: S
authors.lastname: Volinia
authors.forename: George A
authors.initials: GA
authors.lastname: Calin
authors.forename: Louise Y
authors.initials: LY
authors.lastname: Fong
authors.forename: Roberto
authors.initials: R
authors.lastname: Gambari
authors.forename: Arianna
authors.initials: A
authors.lastname: Bottoni
authors.forename: Mario
authors.initials: M
authors.lastname: Acunzo
authors.forename: John
authors.initials: J
authors.lastname: Hagan
authors.forename: Marilena V
authors.initials: MV
authors.lastname: Iorio
authors.forename: Claudia
authors.initials: C
authors.lastname: Piovan
authors.forename: Giulia
authors.initials: G
authors.lastname: Romano
authors.forename: Carlo Maria
authors.initials: CM
authors.lastname: Croce
mesh_terms: D000818:Animals; D001483:Base Sequence; D017124:Conserved Sequence; D004247:DNA / Q000737:chemistry*; D030561:Databases, Nucleic Acid; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000737:chemistry / Q000378:metabolism*; D051381:Rats; D014584:User-Computer Interface
chemical_list: D035683:MicroRNAs; D004247:DNA