Cystatin C or creatinine for detection of stage 3 chronic kidney disease in anorexia nervosa.
BACKGROUND
Patients with anorexia nervosa (AN) are at a high risk of renal failure. Chronic kidney disease (CKD) is often missed in these patients because the serum creatinine is a poor marker of kidney function. We studied the utility of cystatin C to detect renal failure in this population.


METHODS
Twenty-seven AN patients were studied. Glomerular filtration rates (GFR) were measured with the chromium-51- ethylenediaminetetraacetate ((51)Cr-EDTA) method. We compared the ability of creatinine and cystatin C to detect stage 3 CKD (GFR below 60 ml/min) by ROC curve analysis.


RESULTS
In this cohort, there is no correlation between GFR and serum creatinine, but there is a significant correlation between cystatin C and GFR. By ROC analysis, the cystatin C concentration is better than the serum creatinine concentration for the detection of stage 3 CKD (area under the curve of 0.86 vs. 0.61, p = 0.05).


CONCLUSIONS
Plasma cystatin C is better than serum creatinine in detecting stage 3 CKD in patients with AN.
Delanaye
Pierre
P
Department of Nephrology, University of Liège, Liège, Belgium. pierre_delanaye@yahoo.fr
Cavalier
Etienne
E
Radermecker
Régis P
RP
Paquot
Nicolas
N
Depas
Gisèle
G
Chapelle
Jean-Paul
JP
Scheen
André J
AJ
Krzesinski
Jean-Marie
JM
D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000097:blood* / Q000150:complications / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood*; D055316:Cystatin C / Q000097:blood*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D012680:Sensitivity and Specificity; D055815:Young Adult
D015415:Biomarkers; D055316:Cystatin C; D003404:Creatinine