Association of rs2200733 at 4q25 with atrial flutter/fibrillation diseases in an Italian population.
BACKGROUND
Atrial fibrillation (AF) and atrial flutter (AFL) are common cardiac conduction disorders affecting many people. Recent studies on sporadic cases of AF/AFL showed a significant association of the single nucleotide polymorphism rs2200733T with the disease, suggesting a genetic factor in the development of the disease.


OBJECTIVE
To determine the association of rs2200733 with AF/AFL derived from an Italian population sample.


METHODS
78 patients with AF/AFL and 348 controls took part in the study.


METHODS
Genetic case-control study.


RESULTS
The results indicate that there is a positive, significant association between the rs2200733 T allele and patients with AF/AFL of Italian origin (allelic p<0.001 with OR = 2.17).


CONCLUSIONS
These results derived from a sample of the Italian population agree with previously reported findings from an Icelandic study, which also found that the minor allele rs2200733 was associated with AF/AFL disease.
Viviani Anselmi
C
C
Istituto Ricovero Cura Carattere Scientifico Multimedica, Milan, Italy.
Novelli
V
V
Roncarati
R
R
Malovini
A
A
Bellazzi
R
R
Bronzini
R
R
Marchese
G
G
Condorelli
G
G
Montenero
A S
AS
Puca
A A
AA
D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000235:genetics* / Q000503:physiopathology; D001281:Atrial Fibrillation / Q000235:genetics*; D001282:Atrial Flutter / Q000235:genetics*; D016022:Case-Control Studies; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D004562:Electrocardiography; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*