title: Adoptive immunotherapy: good habits instilled at youth have long-term benefits.
abstract: Many recent advances in basic cell biology and immunology are a harbinger of progress in adoptive cell therapy (ACT) including (1) the finding that host lymphodepletion enhances engraftment and efficacy, (2) the recognition that in vitro T cell functions may not correlate with in vivo efficacy, and (3) the development of advanced ex vivo culture methods to expand lymphocytes to therapeutically effective numbers. In this article, we focus on the development of artificial antigen presenting cells (aAPCs) in our laboratory and their applicability to augment ACT protocols. We also describe how aAPCs can be used to broaden ACT to treat patients with a wide variety of cancers, chronic infectious diseases, and autoimmune manifestations.
authors.affiliation: Abramson Family Cancer Research Institute, University of Pennsylvania, BRB II/III, Room 554, 421 Curie Boulevard, Philadelphia, PA, 19104-6160, USA.
authors.forename: Chrystal M
authors.initials: CM
authors.lastname: Paulos
authors.forename: Megan M
authors.initials: MM
authors.lastname: Suhoski
authors.forename: Gabriela
authors.initials: G
authors.lastname: Plesa
authors.forename: Tianying
authors.initials: T
authors.lastname: Jiang
authors.forename: Samik
authors.initials: S
authors.lastname: Basu
authors.forename: Tatiana N
authors.initials: TN
authors.lastname: Golovina
authors.forename: Shuguang
authors.initials: S
authors.lastname: Jiang
authors.forename: Nicole A
authors.initials: NA
authors.lastname: Aqui
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Powell
authors.forename: Bruce L
authors.initials: BL
authors.lastname: Levine
authors.forename: Richard G
authors.initials: RG
authors.lastname: Carroll
authors.forename: James L
authors.initials: JL
authors.lastname: Riley
authors.forename: Carl H
authors.initials: CH
authors.lastname: June
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods*; D020014:K562 Cells; D008213:Lymphocyte Activation / Q000276:immunology; D009369:Neoplasms / Q000276:immunology / Q000473:pathology / Q000628:therapy; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology / Q000637:transplantation; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000637:transplantation*