Postkidney transplant malignancy in Egypt has a unique pattern: a three-decade experience.
The pattern of posttransplant malignancy varies among transplant units. We report on our single-center experience. Between 1976 and 2007, 1866 kidney transplantations were carried out (1390 males and 476 females, mean age 29.84+/-10.47 years). Recipients who developed posttransplant malignancy were evaluated (74 patients, 3.97%). Furthermore, their data were compared with those of the malignancy-free recipients (1792 patients). Kaposi sarcoma was the commonest type (36.8%) and had the shortest transplant-to-malignancy period (mean 2.84 years). The lesions were only cutaneous in 75% of cases. Skin cancers were the fourth among posttransplant malignancies (9.2%) and 85.7% of cases were basal cell carcinoma. In our series, age and prior blood transfusion were identified as independent risk factors for the development of posttransplant malignancy. In conclusion, the prevalence and type of posttransplant malignancy vary because of many factors including environmental and genetic factors. In our series, Kaposi sarcoma was the commonest type and, therefore, needs further evaluation.
Donia
Ahmed F
AF
Urology and Nephrology Center, Mansoura University, Egypt.
Mostafa
Amani
A
Refaie
Hoda
H
El-Baz
Mahmoud
M
Kamal
Mohamed M
MM
Ghoneim
Mohamed A
MA
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D004534:Egypt / Q000453:epidemiology; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000209:etiology* / Q000401:mortality; D015995:Prevalence; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012514:Sarcoma, Kaposi / Q000209:etiology; D013997:Time Factors; D065227:Transfusion Reaction