title: Associations between quality of life, fatigue, and cytokine levels in patients aged 50+ with acute myeloid leukemia.
abstract: OBJECTIVE
  Quality of life (QOL) is significantly impaired in patients with acute myeloid leukemia (AML), and fatigue is the most common and disabling symptom; effective treatment measures have yet to be found. Cytokines, biomarkers of inflammation, may moderate both health outcomes, but published data are limited. We looked at the role of cytokines in modulating QOL and fatigue in an older AML population.
  
  
  METHODS
  We recruited 34 English-speaking patients (23 men, 11 women) aged 50 or older with AML within 1 year of diagnosis. QOL and fatigue were assessed with validated questionnaires. Blood was simultaneously drawn for quantitative measurement of a 13-cytokine panel. Repeat measurements were done 4-6 weeks later (n = 28 patients). Spearman correlations between health measures and cytokine levels were examined at baseline, as were changes in variables between time points. A potentially clinically important correlation was defined as an r > or = 0.30.
  
  
  RESULTS
  At baseline, potentially clinically important correlations were noted between global QOL and interferon (IFN)-gamma (r = -0.376, p = 0.031), interleukin (IL)-2 (r = -0.340, p = 0.053), IL-5 (r = -0.368, p = 0.035), IL-8 (r = -0.312, p = 0.077), and TNF-alpha (r = -0.326, p = 0.064). A similar correlation was observed between IL-6 and fatigue (r = 0.332, p = 0.059). Between time points, there were no potentially important correlations between changes in global QOL and any cytokine. However, potentially important correlations with fatigue were seen with both IL-5 (r = 0.344, p = 0.073) and IL-10 (r = 0.326, p = 0.091) between time points.
  
  
  CONCLUSIONS
  These preliminary data provide support for a larger controlled study of cytokines, fatigue, and QOL in patients with AML.
authors.affiliation: Department of Medicine, University Health Network, Toronto General Hospital, 200 Elizabeth Street (EN14-214), Toronto, Ontario M5G 2C4, Canada.
authors.forename: Abbas H
authors.initials: AH
authors.lastname: Panju
authors.forename: Ali
authors.initials: A
authors.lastname: Danesh
authors.forename: Mark D
authors.initials: MD
authors.lastname: Minden
authors.forename: David J
authors.initials: DJ
authors.lastname: Kelvin
authors.forename: Shabbir M H
authors.initials: SM
authors.lastname: Alibhai
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D016207:Cytokines / Q000097:blood*; D005221:Fatigue / Q000209:etiology* / Q000523:psychology; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000523:psychology; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011788:Quality of Life; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires
chemical_list: D015415:Biomarkers; D016207:Cytokines