Biomarkers: diagnosis and risk assessment in sepsis.
Prompt diagnosis, intervention, and risk assessment are critical in caring for septic patient but remain difficult with currently available methods. Biomarkers may become useful adjuncts to clinicians and ultimately serve as targets for future therapeutic trials in sepsis. The most relevant markers are reviewed in this article, including interleukin-6, C-reactive protein, procalcitonin, triggering receptor expressed on myeloid cells-1, and biomarker panels.
Ventetuolo
Corey E
CE
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University, PH 8, Room 101, 622 W. 168th Street, New York City, NY 10032, USA.
Levy
Mitchell M
MM
D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D002116:Calcitonin / Q000097:blood; D015740:Calcitonin Gene-Related Peptide; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008264:Macrophages / Q000276:immunology; D008562:Membrane Glycoproteins / Q000097:blood; D009000:Monocytes / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D011237:Predictive Value of Tests; D011379:Prognosis; D011498:Protein Precursors / Q000097:blood; D011971:Receptors, Immunologic / Q000097:blood; D018570:Risk Assessment; D018805:Sepsis / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D012772:Shock, Septic / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D000073871:Triggering Receptor Expressed on Myeloid Cells-1
D015415:Biomarkers; C000606589:CALCA protein, human; D015850:Interleukin-6; D008562:Membrane Glycoproteins; D011498:Protein Precursors; D011971:Receptors, Immunologic; C408842:TREM1 protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide