title: The use of chemical double-mutant cycles in biomolecular recognition studies: application to HCV NS3 protease inhibitors.
authors.affiliation: Department of Chemistry, Boehringer Ingelheim (Canada) Ltd., 2100, rue Cunard, Laval, Québec, Canada.
authors.forename: Stephen H
authors.initials: SH
authors.lastname: Kawai
authors.forename: Murray D
authors.initials: MD
authors.lastname: Bailey
authors.forename: Ted
authors.initials: T
authors.lastname: Halmos
authors.forename: Pat
authors.initials: P
authors.lastname: Forgione
authors.forename: Steven R
authors.initials: SR
authors.lastname: Laplante
authors.forename: Montse
authors.initials: M
authors.lastname: Llinàs-Brunet
authors.forename: Julie
authors.initials: J
authors.lastname: Naud
authors.forename: Natalie
authors.initials: N
authors.lastname: Goudreau
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D020134:Catalytic Domain; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D017353:Gene Deletion; D005998:Glycine / Q000737:chemistry; D016174:Hepacivirus / Q000378:metabolism*; D020128:Inhibitory Concentration 50; D008968:Molecular Conformation; D009154:Mutation; D010455:Peptides / Q000737:chemistry; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship; D013816:Thermodynamics; D017361:Viral Nonstructural Proteins / Q000235:genetics* / Q000378:metabolism*; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases
chemical_list: D000998:Antiviral Agents; D005998:Glycine; D010455:Peptides; D017361:Viral Nonstructural Proteins; C084422:NS3 protein, hepatitis C virus; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases