InterPro: the integrative protein signature database.
The InterPro database (http://www.ebi.ac.uk/interpro/) integrates together predictive models or 'signatures' representing protein domains, families and functional sites from multiple, diverse source databases: Gene3D, PANTHER, Pfam, PIRSF, PRINTS, ProDom, PROSITE, SMART, SUPERFAMILY and TIGRFAMs. Integration is performed manually and approximately half of the total approximately 58,000 signatures available in the source databases belong to an InterPro entry. Recently, we have started to also display the remaining un-integrated signatures via our web interface. Other developments include the provision of non-signature data, such as structural data, in new XML files on our FTP site, as well as the inclusion of matchless UniProtKB proteins in the existing match XML files. The web interface has been extended and now links out to the ADAN predicted protein-protein interaction database and the SPICE and Dasty viewers. The latest public release (v18.0) covers 79.8% of UniProtKB (v14.1) and consists of 16 549 entries. InterPro data may be accessed either via the web address above, via web services, by downloading files by anonymous FTP or by using the InterProScan search software (http://www.ebi.ac.uk/Tools/InterProScan/).
Hunter
Sarah
S
EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. hunter@ebi.ac.uk
Apweiler
Rolf
R
Attwood
Teresa K
TK
Bairoch
Amos
A
Bateman
Alex
A
Binns
David
D
Bork
Peer
P
Das
Ujjwal
U
Daugherty
Louise
L
Duquenne
Lauranne
L
Finn
Robert D
RD
Gough
Julian
J
Haft
Daniel
D
Hulo
Nicolas
N
Kahn
Daniel
D
Kelly
Elizabeth
E
Laugraud
Aurélie
A
Letunic
Ivica
I
Lonsdale
David
D
Lopez
Rodrigo
R
Madera
Martin
M
Maslen
John
J
McAnulla
Craig
C
McDowall
Jennifer
J
Mistry
Jaina
J
Mitchell
Alex
A
Mulder
Nicola
N
Natale
Darren
D
Orengo
Christine
C
Quinn
Antony F
AF
Selengut
Jeremy D
JD
Sigrist
Christian J A
CJ
Thimma
Manjula
M
Thomas
Paul D
PD
Valentin
Franck
F
Wilson
Derek
D
Wu
Cathy H
CH
Yeats
Corin
C
D030562:Databases, Protein; D011506:Proteins / Q000737:chemistry / Q000145:classification; D020539:Sequence Analysis, Protein; D018511:Systems Integration
D011506:Proteins