Lipin proteins and metabolic homeostasis.
The lipin protein family, consisting of three members, was first identified early this century. In the last few years, the lipin proteins have been shown to have important roles in glycerolipid biosynthesis and gene regulation, and mutations in the corresponding genes cause lipodystrophy, myoglobinuria, and inflammatory disorders. Here, we review some of the progress toward elucidating the molecular and physiological functions of the lipin proteins.
Reue
Karen
K
Department of Human Genetics, University of California, Los Angeles, CA 90095, USA. reuek@ucla.edu
Dwyer
Jennifer R
JR
D050156:Adipogenesis; D000818:Animals; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000378:metabolism; D008074:Lipoproteins / Q000378:metabolism; D009687:Nuclear Proteins / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D013379:Substrate Specificity
D007328:Insulin; D008074:Lipoproteins; D009687:Nuclear Proteins