Multiple sclerosis outcome and morbi-mortality of a Brazilian cohort patients.
We studied the clinical and evolution characteristics of multiple sclerosis (MS) patients followed since the onset of HUCFF/UFRJ in 1978. The diagnosis of MS was based on Poser's et al. and MC Donald's et al. criteria. From 188 patients, 122 were included. Eighty-five were females. The mean age onset was 32.2 years-old (range 6.0 to 61.0+/-10.3), mainly Caucasians (82/67%). The relapsing-remitting course (MSRR) was more frequent (106/86.8%). Monosymptomatic onset was significantly more frequent in Caucasians than in Afro-Brazilians (p<0.05). Seventeen patients had benign form of MS and these patients presented association with MSRR when compared with severe form (p=0.01). The mortality rate was 2.12% (4 patients died). This study was similar to other Brazilian series with regard to sex and age, and lack of correlation between EDSS and number of relapses; it confirmed south-southeast African-descendants gradient distribution and association between first mono-symptomatic relapses and Caucasian; we found lower frequency of benign forms.
Alves-Leon
Soniza Vieira
SV
Hospital Universitário Clementino Fraga Filho/Universidade Federal do Rio de Janeiro, Rua Professor Rodolpho Paulo Rocco 255, 21941-913 Rio de Janeiro RJ, Brasil. sonizavleon@globo.com
Malfetano
Fabíola Rachid
FR
Pimentel
Maria Lucia Veluttini
ML
Estrada
Claudio Luiz Duque
CL
Pereira
Valéria Coelho Santa Rita
VC
Liem
Assuncíon Martinez
AM
Novis
Sérgio Augusto Pereira
SA
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001938:Brazil / Q000453:epidemiology; D002648:Child; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000145:classification / Q000150:complications / Q000401:mortality*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000150:complications / Q000401:mortality*; D012720:Severity of Illness Index; D055815:Young Adult