title: Estrogen receptor 2 polymorphism and carotid intima-media thickness.
abstract: OBJECTIVE
  The present study was designed to investigate the effects of estrogen receptor 2 gene (ESR2) rs1256049 polymorphism to carotid artery intima-media thickness (CIMT), as part of the Cardiovascular Risk in Young Finns Study.
  
  
  RESULTS
  The frequencies of ESR2 genotypes G/G, G/A, and A/A were 85.1%, 14.3%, and 0.7%, respectively, in the whole study population (n = 2211). Compared with subjects with genotype GG, those with the A allele had higher mean CIMT (p = 0.004) and maximal CIMT (p = 0.005).
  
  
  CONCLUSIONS
  In a Finnish population, the ESR2 rs1256049 polymorphism A allele is associated with preclinical atherosclerosis in young adulthood. Our results and those of others also suggest that some effects of this genetic variation may be population specific.
authors.affiliation: Department of Medical Biochemistry, University of Tampere Medical School , Tampere, Finland. seppo.nikkari@uta.fi
authors.forename: Seppo T
authors.initials: ST
authors.lastname: Nikkari
authors.forename: Antti
authors.initials: A
authors.lastname: Henttonen
authors.forename: Tarja
authors.initials: T
authors.lastname: Kunnas
authors.forename: Mika
authors.initials: M
authors.lastname: Kähönen
authors.forename: Nina
authors.initials: N
authors.lastname: Hutri-Kähönen
authors.forename: Markus
authors.initials: M
authors.lastname: Juonala
authors.forename: Jukka
authors.initials: J
authors.lastname: Marniemi
authors.forename: Jorma
authors.initials: J
authors.lastname: Viikari
authors.forename: Olli T
authors.initials: OT
authors.lastname: Raitakari
authors.forename: Terho
authors.initials: T
authors.lastname: Lehtimäki
mesh_terms: D000328:Adult; D000483:Alleles; D050197:Atherosclerosis / Q000000981:diagnostic imaging / Q000235:genetics; D002339:Carotid Arteries / Q000000981:diagnostic imaging*; D047629:Estrogen Receptor beta / Q000235:genetics*; D005260:Female; D005387:Finland; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D017539:Tunica Intima / Q000000981:diagnostic imaging; D014463:Ultrasonography
chemical_list: D047629:Estrogen Receptor beta