Development of biodegradable drug releasing polymeric cardiovascular stents and in vitro evaluation.
Prednisolone acetate (PA) is insoluble in water and was chosen as a model drug for its anti-inflammatory/anti-proliferative functions. PA is incorporated into the film-based polymeric biodegradable stents to provide controlled local release of the drug during the mechanical support phase. Stent formulations were 3 mm in diameter with lengths of 150 mm. The polymer wall thickness was 145.0 +/- 4.0 microm for microsphere-containing PLGA 75 : 25 stents. The ATR-FTIR spectra showed biodegradable stent surfaces were free of drug and microspheres. Incorporation of PA into the stents increased the surface area when compared to empty and microsphere-incorporated stents. PA release from the stents containing chitosan microspheres was slower than the PA-only incorporated stents. The drug release from the stents coated with microsphere-containing PLGA 75 : 25 solutions was determined to be the slowest one (19.1% cumulative PA released in 32 days). The stents formulated with PLGA 75 : 25 polymers were considered to be more promising due to their suitable mechanical properties and controlled release of the drug.
Sarisözen
Can
C
Faculty of Pharmacy, Department of Pharmaceutical Technology, Hacettepe University, Sihhiye-Ankara, Turkey.
Arica
Betül
B
Hincal
A Atilla
AA
Caliş
Sema
S
D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001672:Biocompatible Materials / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D003692:Delayed-Action Preparations / Q000737:chemistry; D019344:Lactic Acid / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011239:Prednisolone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D017550:Spectroscopy, Fourier Transform Infrared; D015607:Stents
D000893:Anti-Inflammatory Agents; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C009935:prednisolone acetate; D011239:Prednisolone