title: Burden and trends of type-specific human papillomavirus infections and related diseases in the latin america and Caribbean region.
abstract: We present the burden of human papillomavirus (HPV)-related cancers (cancers of the cervix, anogenital region, oral cavity and pharynx) in terms of incidence and mortality, for the countries of the Latin America and Caribbean region. The region is a high-risk area for cancer of the cervix and, although incidence has declined since the 1960s, projected demographic changes imply that the actual burden of new cases will increase by more than 75% in the next 20 years, while the average and at diagnosis will increase. Approximately 65% of cervical cancer cases and 50% of the high risk lesions are associated with HPV-16 and 18. Incidence rates of other HPV-related cancers are significantly lower. The paper also describes the estimated impact of genital warts and the limited data available on the occurrence of HPV infections of the upper aerodigestive tract in the region.
authors.affiliation: Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, United Kingdom. max.parkin@ctsu.ox.ac.uk
authors.forename: D Maxwell
authors.initials: DM
authors.lastname: Parkin
authors.forename: Maribel
authors.initials: M
authors.lastname: Almonte
authors.forename: Laia
authors.initials: L
authors.lastname: Bruni
authors.forename: Gary
authors.initials: G
authors.lastname: Clifford
authors.forename: Maria-Paula
authors.initials: MP
authors.lastname: Curado
authors.forename: Marion
authors.initials: M
authors.lastname: Piñeros
mesh_terms: D017691:Caribbean Region / Q000453:epidemiology; D003218:Condylomata Acuminata / Q000453:epidemiology; D005260:Female; D006801:Humans; D007843:Latin America / Q000453:epidemiology; D008297:Male; D010212:Papilloma / Q000453:epidemiology; D030361:Papillomavirus Infections / Q000150:complications / Q000453:epidemiology* / Q000401:mortality / Q000517:prevention & control; D010412:Penile Neoplasms / Q000453:epidemiology / Q000209:etiology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000401:mortality