title: Fetal intraventricular bleeding possibly due to maternal vitamin K deficiency.
abstract: We report a rare case of fetal intraventricular bleeding possibly due to maternal vitamin K deficiency. A 20-year-old woman was admitted to our hospital due to impending premature delivery and loss of dietary intake at 28 weeks of gestation. Her blood examination showed metabolic alkalosis, prolonged prothrombin time, and extremely high level of plasma des-gamma-carboxyprothrombin (protein induced by vitamin K absence, PIVKA-II). Intraventricular hemorrhage was demonstrated by ultrasonography 6 days after admission. She delivered a 2,288-gram girl infant at 40 weeks of gestation. Cranial computerized tomography and magnetic resonance images obtained postnatally demonstrated a reduced cerebral parenchyma adjacent to the interior side of the right lateral ventricle and the deficit of left cerebellum. The infant's head control was insufficient and central impaired hearing was noted at 6 months of life.
authors.affiliation: Department of Obstetrics and Gynecology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan.
authors.forename: Hiroji
authors.initials: H
authors.lastname: Minami
authors.forename: Madoka
authors.initials: M
authors.lastname: Furuhashi
authors.forename: Kojiro
authors.initials: K
authors.lastname: Minami
authors.forename: Ken
authors.initials: K
authors.lastname: Miyazaki
authors.forename: Kana
authors.initials: K
authors.lastname: Yoshida
authors.forename: Kaoru
authors.initials: K
authors.lastname: Ishikawa
mesh_terms: D002552:Cerebral Ventricles; D001068:Feeding and Eating Disorders / Q000150:complications; D005260:Female; D005315:Fetal Diseases / Q000097:blood / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn; D020300:Intracranial Hemorrhages / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology*; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology*; D016216:Ultrasonography, Prenatal; D014813:Vitamin K Deficiency / Q000097:blood / Q000150:complications*; D014839:Vomiting / Q000150:complications; D055815:Young Adult