Flow-injection chemiluminescence determination of chloroquine using peroxynitrous acid as oxidant.
A new flow-injection chemiluminescence (CL) method for determination of chloroquine is proposed based on a stronger chemiluminescence of chloroquine in hydrogen peroxide-nitrite-sulfuric acid medium. The proposed method allows the measurement of chloroquine over the range of 3.0x10(-7) to 1.0x10(-5)moll(-1). The detection limit is 8.6x10(-8)moll(-1), and the relative standard deviation for 1.0x10(-6)moll(-1) chloroquine (n=11) is 1.6%. The CL mechanism is also discussed.
Liang
Yao-Dong
YD
Institute of Analytical Science, Northwest University, Xi'an 710069, PR China.
Song
Jun-Feng
JF
Yang
Xiao-Feng
XF
Guo
Wei
W