title: Method for rapid calculation of quantitative cerebral perfusion.
abstract: OBJECTIVE
  To evaluate an algorithm based on algebraic estimation of T1 values (three-point estimation) in comparison with computational curve-fitting for the postprocessing of quantitative cerebral perfusion scans.
  
  
  METHODS
  Computer simulations were performed to quantify the magnitude of the expected error on T1 and consequently cerebral perfusion using the three-point estimation technique on a Look-Locker (LL) EPI scan. In 50 patients, quantitative cerebral perfusion was calculated using the bookend method with three-point estimation and curve-fitting. The bookend method, a novel approach for calculating quantitative cerebral perfusion based on changes in T1 values after a contrast injection, is currently being validated. The number of computations was used as a measure of computation speed for each method. Student's paired t-test, Bland-Altman, and correlation analyses were performed to evaluate the accuracy of estimation.
  
  
  RESULTS
  There was a 99.65% reduction in the number of computations with three-point estimation. Student's t-test showed no significant difference in cerebral perfusion (P=0.80, 0.49, paired t-test N=50, quantitative cerebral blood flow-white matter [qCBF-WM], qCBF-gray matter [qCBF-GM]) when compared to curve-fitting. The results of the two techniques were strongly correlated in patients (slope=0.99, intercept=1.58 mL/(100 g/minute), r=0.86) with a small systemic bias of -0.97 mL/(100 g/minute) in Bland-Altman analysis.
  
  
  CONCLUSIONS
  The three-point estimation technique is adequate for rapid calculation of qCBF. The estimation scheme drastically reduces processing time, thus making the method feasible for clinical use.
authors.affiliation: Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, USA.
authors.forename: Maulin K
authors.initials: MK
authors.lastname: Shah
authors.forename: Wanyong
authors.initials: W
authors.lastname: Shin
authors.forename: Jessy
authors.initials: J
authors.lastname: Mouannes
authors.forename: Ali
authors.initials: A
authors.lastname: Shaibani
authors.forename: Sandra W
authors.initials: SW
authors.lastname: Horowitz
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Carroll
mesh_terms: D000465:Algorithms; D001783:Blood Flow Velocity; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D001927:Brain Diseases / Q000175:diagnosis* / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012984:Software