title: Grignard cross-coupling amenable to large scale production of alpha-fluorostyryl and alpha-fluorovinylthiophenes.
abstract: An efficient nickel-catalyzed Kumada-Corriu cross coupling enabled the introduction of an alpha-fluorovinyl functionality with excellent conversion and specificity.
authors.affiliation: Replidyne Inc., 1450 Infinite Drive, Louisville, Colorado 80027, USA.
authors.forename: Jian
authors.initials: J
authors.lastname: Qiu
authors.forename: Albert
authors.initials: A
authors.lastname: Gyorokos
authors.forename: Theodore M
authors.initials: TM
authors.lastname: Tarasow
authors.forename: Joseph
authors.initials: J
authors.lastname: Guiles
mesh_terms: D002384:Catalysis; D002851:Chromatography, High Pressure Liquid; D003460:Crystallization; D007202:Indicators and Reagents; D009532:Nickel / Q000737:chemistry; D013696:Temperature; D013876:Thiophenes / Q000138:chemical synthesis*; D014753:Vinyl Compounds / Q000138:chemical synthesis*
chemical_list: D007202:Indicators and Reagents; D013876:Thiophenes; D014753:Vinyl Compounds; D009532:Nickel