title: Cross-correlation delay to quantify myocardial dyssynchrony from phase contrast magnetic resonance (PCMR) velocity data.
abstract: OBJECTIVE
  To apply cross-correlation delay (XCD) analysis to myocardial phase contrast magnetic resonance (PCMR) tissue velocity data and to compare XCD to three established "time-to-peak" dyssynchrony parameters.
  
  
  METHODS
  Myocardial tissue velocity was acquired using PCMR in 10 healthy volunteers (negative controls) and 10 heart failure patients who met criteria for cardiac resynchronization therapy (positive controls). All dyssynchrony parameters were computed from PCMR velocity curves. Sensitivity, specificity, and receiver operator curve (ROC) analysis for separating positive and negative controls were computed for each dyssynchrony parameter.
  
  
  RESULTS
  XCD had higher sensitivity (90%) and specificity (100%) for discriminating between normal and patient groups than any of the time-to-peak dyssynchrony parameters. ROC analysis showed that XCD was the best parameter for separating the positive and negative control groups.
  
  
  CONCLUSIONS
  XCD is superior to time-to-peak dyssynchrony parameters for discriminating between subjects with and without dyssynchrony and may aid in the selection of patients for cardiac resynchronization therapy.
authors.affiliation: Department of Radiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA. jana.delfino@emory.edu
authors.forename: Jana G
authors.initials: JG
authors.lastname: Delfino
authors.forename: Brandon K
authors.initials: BK
authors.lastname: Fornwalt
authors.forename: Robert L
authors.initials: RL
authors.lastname: Eisner
authors.forename: Angel R
authors.initials: AR
authors.lastname: Leon
authors.forename: John N
authors.initials: JN
authors.lastname: Oshinski
mesh_terms: D000328:Adult; D000465:Algorithms; D001145:Arrhythmias, Cardiac / Q000175:diagnosis*; D005260:Female; D006333:Heart Failure / Q000175:diagnosis*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D012044:Regression Analysis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis*