Description of radiation- and ultrasound-induced cell death by a stochastic process.
Cell survival is a stochastic process with the stochastic component being strongly dependent on the irradiation conditions. This process is described by a stochastic model which allows differentiation between the deterministic and stochastic components of survival. The proposed model is tested for four irradiation experiments (2 with ionizing radiation and 2 with ultrasound) and very good agreement with experimental results is demonstrated. It identifies the higher stochasticity of the cell survival for the temporally varying radiation fields and provides the possibility to compare the stochasticity of survival in different radiation fields.
Sontag
Werner
W
Forschungszentrum Karlsruhe, Institut für Biologische Grenzflächen, Postfach 3640, 76021, Karlsruhe, Germany. werner.sontag@ibg.fzk.de
Kruglikov
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IL
D000818:Animals; D016923:Cell Death / Q000528:radiation effects; D002460:Cell Line; D002470:Cell Survival / Q000528:radiation effects; D006801:Humans; D051379:Mice; D008954:Models, Biological; D051381:Rats; D013269:Stochastic Processes; D013997:Time Factors; D014465:Ultrasonics / Q000009:adverse effects*