Determination of methotrexate in human blood plasma by adsorptive stripping voltammetry.
The use of adsorptive stripping voltammetry to measure sub-micromolar concentrations of methotrexate in plasma has been investigated. A simple clean-up procedure has been developed in which methotrexate is extracted from blood plasma with Amberlite XAD-2, which is a non-ionic resin, and eluted with methanol. Recovery for plasma analysis was 80%.
Temizer
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Department of Analytical Chemistry, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Turkey.
Nur Onar
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