Myosin learns to recruit AMPA receptors.
The induction of long-term potentiation (LTP) leads to an increase in the density of AMPA receptors at dendritic spines. New work by Wang et al. (2008) reveals the mechanism by which myosin Vb regulates the intracellular trafficking of AMPA receptors from recycling endosomes to synaptic sites during LTP.
Perlson
Eran
E
Department of Physiology, University of Pennsylvania School of Medicine, D400 Richards Building, 3700 Hamilton Walk, Philadelphia, PA, 19104-6085, USA.
Holzbaur
Erika L F
EL
D000818:Animals; D049229:Dendritic Spines / Q000378:metabolism; D011992:Endosomes; D017774:Long-Term Potentiation; D009218:Myosins / Q000378:metabolism*; D018091:Receptors, AMPA / Q000378:metabolism*; D015398:Signal Transduction
D018091:Receptors, AMPA; D009218:Myosins