title: Anodic polarographic determination of flucloxacillin.
abstract: The hydrolysis of flucloxacillin at pH 4.9 yields a degradation product which is polarographically oxidizable. This derivative has not been identified, but would seem to contain a thiol group. It gives a diffusion-controlled anodic polarographic wave with a half-wave potential at -0.24 V vs. SCE. The method developed has been applied to the analysis of flucloxacillin capsules, and a recovery of 99% has been obtained.
authors.affiliation: Department of Chemical Pharmacology and Physical Chemistry, Faculty of Chemical and Pharmacological Sciences, P.O. Box 233, Santiago, Chile.
authors.forename: J A
authors.initials: JA
authors.lastname: Squella
authors.forename: M M
authors.initials: MM
authors.lastname: Silva
authors.forename: L J
authors.initials: LJ
authors.lastname: Nuñez-Vergara