title: Effects of the lactase 13910 C/T and calcium-sensor receptor A986S G/T gene polymorphisms on the incidence and recurrence of colorectal cancer in Hungarian population.
abstract: BACKGROUND
  Epidemiological studies suggested the chemopreventive role of higher calcium intake in colorectal carcinogenesis. We examined genetic polymorphisms that might influence calcium metabolism: lactase (LCT) gene 13910 C/T polymorphism causing lactose intolerance and calcium-sensing receptor (CaSR) gene A986S polymorphism as a responsible factor for the altered cellular calcium sensation.
  
  
  METHODS
  538 Hungarian subjects were studied: 278 patients with colorectal cancer and 260 healthy controls. Median follow-up was 17 months. After genotyping, the relationship between LCT 13910 C/T and CaSR A986S polymorphisms as well as tumor incidence/progression was investigated.
  
  
  RESULTS
  in patient with colorectal cancer, a significantly higher LCT CC frequency was associated with increased distant disease recurrence (OR = 4.04; 95% CI = 1.71-9.58; p = 0.006). The disease free survival calculated from distant recurrence was reduced for those with LCT CC genotype (log rank test p = 0.008). In case of CaSR A986S polymorphism, the homozygous SS genotype was more frequent in patients than in controls (OR = 4.01; 95% CI = 1.33-12.07; p = 0.014). The number of LCT C and CaSR S risk alleles were correlated with tumor incidence (p = 0.035). The CCSS genotype combination was found only in patients with CRC (p = 0.033).
  
  
  CONCLUSIONS
  LCT 13910 C/T and CaSR A986S polymorphisms may have an impact on the progression and/or incidence of CRC.
authors.affiliation: First Department of Medicine, Semmelweis University, Budapest 1083 Korányi Sándor u 2/a, Hungary. bacsi@bel1.sote.hu
authors.forename: Krisztián
authors.initials: K
authors.lastname: Bácsi
authors.forename: Erika
authors.initials: E
authors.lastname: Hitre
authors.forename: János P
authors.initials: JP
authors.lastname: Kósa
authors.forename: Henrik
authors.initials: H
authors.lastname: Horváth
authors.forename: Aron
authors.initials: A
authors.lastname: Lazáry
authors.forename: Péter L
authors.initials: PL
authors.lastname: Lakatos
authors.forename: Bernadett
authors.initials: B
authors.lastname: Balla
authors.forename: Barna
authors.initials: B
authors.lastname: Budai
authors.forename: Péter
authors.initials: P
authors.lastname: Lakatos
authors.forename: Gábor
authors.initials: G
authors.lastname: Speer
mesh_terms: D015179:Colorectal Neoplasms / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D018450:Disease Progression; D005260:Female; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D015994:Incidence; D043322:Lactase / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D044169:Receptors, Calcium-Sensing / Q000235:genetics*
chemical_list: D044169:Receptors, Calcium-Sensing; D043322:Lactase