Antimicrobial activity of ethylenediaminedisuccinate metal complexes.
It is shown that metal complexes of the biodegradable ligand ethylenediaminedisuccinic acid (edds) present antimicrobial activity towards fungi and bacteria. [Cd(edds)], in particular, is more toxic than free Cd2+ to Aspergillus niger, behaving as a 'Trojan Horse' in the facilitated delivery of the toxic metal into the fungus.
Costa
Natália J S
NJS
University of São Paulo, Institute of Chemistry, Av. Lineu Prestes 748 sala 1265, 05508-000, São Paulo, Brazil (phone: +55-11-3091-2181; fax: +55-11-3815-5579).
Bombardieri
Cíntia R
CR
University of São Paulo, Institute of Biomedical Sciences, Av. Lineu Prestes 2415, 05508-000, São Paulo, Brazil.
Kuribayashi
Juliana S
JS
University of São Paulo, Institute of Biomedical Sciences, Av. Lineu Prestes 2415, 05508-000, São Paulo, Brazil.
de Camargo
Maristela M
MM
University of São Paulo, Institute of Biomedical Sciences, Av. Lineu Prestes 2415, 05508-000, São Paulo, Brazil.
Andrade
Leandro H
LH
University of São Paulo, Institute of Chemistry, Av. Lineu Prestes 748 sala 1265, 05508-000, São Paulo, Brazil (phone: +55-11-3091-2181; fax: +55-11-3815-5579).
Kagohara
Edna
E
University of São Paulo, Institute of Chemistry, Av. Lineu Prestes 748 sala 1265, 05508-000, São Paulo, Brazil (phone: +55-11-3091-2181; fax: +55-11-3815-5579).
Espósito
Breno P
BP
University of São Paulo, Institute of Chemistry, Av. Lineu Prestes 748 sala 1265, 05508-000, São Paulo, Brazil (phone: +55-11-3091-2181; fax: +55-11-3815-5579).
D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D001234:Aspergillus niger / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects; D002460:Cell Line; D005029:Ethylenediamines / Q000737:chemistry*; D006801:Humans; D019216:Metals, Heavy / Q000737:chemistry* / Q000494:pharmacology; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D055494:Pycnoporus / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D013386:Succinates / Q000737:chemistry*
D000890:Anti-Infective Agents; D005029:Ethylenediamines; D019216:Metals, Heavy; D009942:Organometallic Compounds; D013386:Succinates; C041447:N,N'-ethylenediamine disuccinic acid