Near infra-red reflectance spectroscopic determination of metformin in tablets.
A rapid and simple near infra red reflectance spectroscopic method was described for determination of anti-diabetic tablets. Partial least squares method was applied to the Savitsky-Golay smoothed first derivative spectral data revealed over wavelength range 1000-2500 nm from 11 different pulverized tablet batches in 2-mm quartz cell. The results were agreed well with those obtained by the official British Pharmacopoiea 1998 UV assay of metformin.
Habib
I H I
IH
Microanalytical Chem. Lab., National Research Centre, El-Tahrir Str., Dokki, Cairo, Egypt.
Kamel
M S
MS