title: Specific rotation measurements from peak height data, with a Gaussian peak model.
abstract: A method is described whereby a sensitive laser-based polarimeter can be used to make very accurate and precise specific rotation measurements on microgram quantities of optically active materials. Flow-injection or liquid chromatography systems provide reproducible introduction of the sample into the polarimetric system. If a Gaussian distribution of the analyte concentration is assumed, the peak height can be used in the determination of specific rotation. This method provides a direct calibration with an absolute standard which yields more accurate and precise results than those obtainable by using peak area.
authors.affiliation: Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, Arkansas 72701, U.S.A.
authors.forename: P D
authors.initials: PD
authors.lastname: Rice
authors.forename: Y Y
authors.initials: YY
authors.lastname: Shao
authors.forename: S R
authors.initials: SR
authors.lastname: Erskine
authors.forename: T G
authors.initials: TG
authors.lastname: Teague
authors.forename: D R
authors.initials: DR
authors.lastname: Bobbitt