Association of IL-6 gene polymorphism with the outcome of allogeneic haematopoietic stem cell transplantation in Czech patients.
Interleukin-6 (IL-6) is an important pro-inflammatory mediator implicated in immune-mediated complications of allogeneic haematopoietic stem cell transplantation (aHSCT). In accord with previous reports, this preliminary study on 56 donor-recipient pairs revealed IL-6-174 single nucleotide polymorphisms as a risk factor for the development of acute graft-versus-host disease and decreased survival after aHSCT.
Ambruzova
Z
Z
Department of Immunology, Tissue Typing Laboratory, Palacky University Olomouc, Czech Republic.
Mrazek
F
F
Raida
L
L
Faber
E
E
Onderkova
J
J
Kriegova
E
E
Indrak
K
K
Petrek
M
M
D000293:Adolescent; D000328:Adult; D000483:Alleles; D018153:Czech Republic; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006086:Graft vs Host Disease / Q000235:genetics* / Q000276:immunology / Q000401:mortality; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000401:mortality; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics* / Q000276:immunology; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D014184:Transplantation, Homologous / Q000276:immunology*; D055815:Young Adult
D015850:Interleukin-6