title: Electrochemical reduction and voltammetric determination of metronidazole at a nanomaterial thin film coated glassy carbon electrode.
abstract: Simple and sensitive electrochemical method for the determination of metronidazole, based on a nanostructured film coated glassy carbon electrode (GCE), is described. Multi-walled carbon nanotubes (MWNT) was dispersed into water in the presence of a hydrophobic surfactant to give very stable and homogeneous MWNT suspension, and a MWNT-film coated GCE was achieved via evaporating solvent. Metronidazole yields a well-defined reduction peak whose potential is -0.71V at the MWNT-film coated GCE in pH 9.0 Britton-Robinson buffer. Compared with bare GCE, the MWNT-film modified GCE significantly enhances the reduction peak current of metronidazole. All the experimental parameters were optimized for the determination of metronidazole. The detection limit is 6x10(-9)mol/l at 2min accumulation. This method has been successfully used to determine metronidazole in the drugs. Furthermore, results obtained by the proposed method have been compared with spectrophotometric method.
authors.affiliation: Department of Chemistry, Xiaogan University, Xiaogan 432100, Hubei, China.
authors.forename: Shaofang
authors.initials: S
authors.lastname: Lu
authors.forename: Kangbing
authors.initials: K
authors.lastname: Wu
authors.forename: Xueping
authors.initials: X
authors.lastname: Dang
authors.forename: Shengshui
authors.initials: S
authors.lastname: Hu