title: FIA-spectrophotometric determination of N-substituted phenothiazine derivatives by oxidation with a solid-phase reactor of manganese dioxide incorporated in polyester resin beads.
abstract: The determination of several N-substituted phenothiazine derivatives was carried out by the reaction of the drug with managanese dioxide entrapped in a polymeric material in a packed-bed reactor; the oxidized drug was monitored at lambda(max). The calibration graph is linear over the range 5-50 mug/ml of phenothiazine derivatives with a relative standard deviation of 0.5-1% (at 10 mug/ml) and sample throughput of 40-48 h(-1). The influence of foreign compounds was studied and the method was applied to the determination of six different phenothiazine derivatives in pharmaceutical formulations.
authors.affiliation: Institute of Chemistry, Warsaw University Branch at Białystok, 15-443 Białystok, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Kojło
authors.forename: J M
authors.initials: JM
authors.lastname: Calatayud