title: New concepts in the pathogenesis of Sjögren's syndrome.
abstract: Sjögren's syndrome (SS) is a rheumatic disease in which the salivary and lacrimal glands are the principal targets of a pathologic autoimmune reaction. SS is manifested by xerostemia and keratoconjunctivitis sicca and marked by persistent focal mononuclear cell infiltration within the salivary glands, often accompanied by glandular atrophy and fibrosis. A challenge is to clarify the roles of genetic backgrounds and environmental trigger. Advanced bioanalytic platforms have enabled identification of potential biomarkers with the intent to improve diagnosis, promote development of prognostic tools, and identify processes for therapeutic treatment. Such approaches allow a glimpse at the apparent complexity of SS.
authors.affiliation: Broegelmann Research Laboratory, The Gade Institute, University of Bergen, Haukelandsveien 28, Bergen 5021, Norway.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Delaleu
authors.forename: Malin V
authors.initials: MV
authors.lastname: Jonsson
authors.forename: Silke
authors.initials: S
authors.lastname: Appel
authors.forename: Roland
authors.initials: R
authors.lastname: Jonsson
mesh_terms: D015551:Autoimmunity; D015415:Biomarkers; D006801:Humans; D012859:Sjogren's Syndrome / Q000209:etiology*
chemical_list: D015415:Biomarkers