title: Disruption of learned timing in P/Q calcium channel mutants.
abstract: To optimize motor performance, both the amplitude and temporal properties of movements should be modifiable by motor learning. Here we report that the modification of movement timing is highly dependent on signaling through P/Q-type voltage-dependent calcium channels. Two lines of mutant mice heterozygous for P/Q-type voltage-dependent calcium channels exhibited impaired plasticity of eye movement timing, but relatively intact plasticity of movement amplitude during motor learning in the vestibulo-ocular reflex. The results thus demonstrate a distinction between the molecular signaling pathways regulating the timing versus amplitude of movements.
authors.affiliation: Department of Neurobiology, Stanford University, Stanford, CA, USA.
authors.forename: Akira
authors.initials: A
authors.lastname: Katoh
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Chapman
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Raymond
mesh_terms: D000818:Animals; D020864:Calcium Channels, N-Type; D020865:Calcium Channels, P-Type / Q000235:genetics / Q000378:metabolism*; D020907:Calcium Channels, Q-Type / Q000235:genetics / Q000378:metabolism*; D005133:Eye Movements / Q000502:physiology*; D019416:Head Movements / Q000502:physiology; D007858:Learning / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009154:Mutation; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013997:Time Factors
chemical_list: D020864:Calcium Channels, N-Type; D020865:Calcium Channels, P-Type; D020907:Calcium Channels, Q-Type