title: Changes in serum interleukin-6, C-reactive protein and thrombomodulin levels under periodontal ultrasonic debridement.
abstract: OBJECTIVE
  This study aimed to compare the effect of single-visit full-mouth mechanical debridement (FMD) and quadrant-wise mechanical debridement (QMD) on the levels of serum interleukin (IL)-6, C-reactive protein (CRP) and soluble thrombomodulin.
  
  
  METHODS
  Thirty-six subjects with chronic periodontitis were randomly allocated to three groups: undergoing QMD, single-visit FMD with povidone iodine or with water. Serum IL-6 and soluble thrombomodulin were measured by enzyme-linked immunosorbent assay, and serum CRP was measured by the latex-enhanced nephelometric method.
  
  
  RESULTS
  Serum IL-6 level increased significantly immediately after debridement in all the three groups, with this increase being greatest in the full-mouth groups. However, the increase in the full-mouth groups was not significantly higher than that of quadrant-wise group. In the quadrant-wise group, serum IL-6 level decreased significantly 1 month after debridement compared with baseline. Serum-soluble thrombomodulin decreased significantly in the full-mouth groups but not in the quadrant-wise group. Changes in CRP level were not significant at baseline or after debridement in all the three groups.
  
  
  CONCLUSIONS
  FMD increased serum IL-6 and reduced serum-soluble thrombomodulin to a greater extent than QMD, suggesting that the former technique has stronger transient effects on systemic vascular endothelial functions than the latter.
authors.affiliation: Department of Hard Tissue Engineering, Section of Periodontology, Graduate School, Tokyo, Japan. ushida.peri@tmd.ac.jp
authors.forename: Yuka
authors.initials: Y
authors.lastname: Ushida
authors.forename: Geena
authors.initials: G
authors.lastname: Koshy
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kawashima
authors.forename: Makoto
authors.initials: M
authors.lastname: Kiji
authors.forename: Makoto
authors.initials: M
authors.lastname: Umeda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nitta
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Nagasawa
authors.forename: Isao
authors.initials: I
authors.lastname: Ishikawa
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Izumi
mesh_terms: D000328:Adult; D000368:Aged; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D002097:C-Reactive Protein / Q000032:analysis*; D002318:Cardiovascular Diseases; D055113:Chronic Periodontitis / Q000097:blood* / Q000628:therapy*; D017742:Dental Care for Chronically Ill; D012534:Dental Scaling / Q000379:methods*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011206:Povidone-Iodine / Q000627:therapeutic use; D018180:Thrombomodulin / Q000097:blood*; D014464:Ultrasonic Therapy
chemical_list: D000891:Anti-Infective Agents, Local; D015850:Interleukin-6; D018180:Thrombomodulin; D011206:Povidone-Iodine; D002097:C-Reactive Protein