The use of 2,3-dichloro-5,6-dicyano-p-benzoquinone for the spectrophotometric determination of some cardiovascular drugs.
Some basic cardiovascular drugs containing secondary or tertiary amino groups are determined spectrophotometrically. The method is simple and sensitive; it is based on the interaction of the drugs, as n-electron donors, with 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) as a pi-acceptor. The highly coloured radical anion exhibits maximum absorption at 460 nm. The drugs determined are pindolol, dipyridamole, hydralazine hydrochloride, quinidine sulphate, prenylamine lactate and tolazoline hydrochloride. Beer's law is obeyed for these drugs. The procedure is sensitive enough to permit unit dose assay of the individual drugs in their pharmaceutical formulations. The assay results are in accord with the pharmacopoeial assay results.
Issa
A S
AS
Pharmaceutical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt.
Mahrous
M S
MS
Salam
M A
MA
Soliman
N
N