Microbial metabolites of 8-prenylnaringenin, an estrogenic prenylflavanone.
Microbial metabolism studies of the phyto-estrogen (+/-)-8-prenylnaringenin (8-PN) (1) has led to the isolation of three pairs of metabolites (2-4). The structures of these compounds were identified as 5,4'-dihydroxy-7,8-[2-(1-hydroxy-1-methylethyl)-2,3-dihydrofurano]flavanones (2), 8-prenylnaringenin 7-O-beta-D-glucopyranosides (3), and 8-prenylnaringenin 7-O-beta-D-(6'''-O-alpha-hydroxypropionyl)-glucopyranosides (4) on the basis of the spectroscopic analysis.
Kim
Hyun Jung
HJ
College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, Korea.
Kim
So-Hyun
SH
Kang
Bok Yun
BY
Lee
Ik-Soo
IS
D001419:Bacteria / Q000378:metabolism; D002236:Carbohydrate Conformation; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D020093:Cunninghamella / Q000378:metabolism; D005285:Fermentation; D044950:Flavanones / Q000378:metabolism*; D005658:Fungi / Q000378:metabolism*; D027582:Humulus / Q000737:chemistry*; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D009089:Mucor / Q000378:metabolism; D048789:Phytoestrogens / Q000378:metabolism*; D012233:Rhizopus / Q000378:metabolism; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
C119737:8-prenylnaringenin; D044950:Flavanones; D048789:Phytoestrogens