Is GPR39 the natural receptor of obestatin?
GPR39, an orphan receptor belonging to the family of G protein-coupled receptors, was originally reported to be the receptor of obestatin. However recently, numerous reports have questioned this conclusion. In mammals, GPR39 was reported to be involved in the regulation of gastrointestinal and the metabolic functions. In this article, a latest and brief review on the receptor family, structure, distribution and physiological functions of GPR39 has been reported.
Dong
Xiao-Ying
XY
College of Yingdong Bioengineering, Shaoguan University, Daxue Avenue, Zhenjiang District, Shaoguan 512005, China.
He
Jin-Ming
JM
Tang
Sheng-Qiu
SQ
Li
Hai-Yun
HY
Jiang
Qing-Yan
QY
Zou
Xiao-Ting
XT
D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis; D049109:Cell Proliferation; D004435:Eating; D005769:Gastrointestinal Motility; D054439:Ghrelin / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry* / Q000378:metabolism
C495797:GPR39 protein, human; C512928:GPR39 protein, mouse; D054439:Ghrelin; D043562:Receptors, G-Protein-Coupled