Spectroscopic, thermal and biological studies of the coordination compounds of sulfasalazine drug: Mn(II), Hg(II), Cr(III), ZrO(II), VO(II) and Y(III) transition metal complexes.
The complexations of sulfasalazine (H3Suz) with some of transition metals have been investigated. Three types of complexes, [Mn(HSuz)-2(H2O)4] x 2H2O, [M(HSuz)-2(H2O)2] x xH2O (M=Hg(II), ZrO(II) and VO(II), x=4, 8 and 6, respectively) and [M(HSuz)-2(Cl)(H2O)3] x xH2O (M=Cr(III) and Y(III), x=5 and 6, respectively) were obtained and characterized by physicochemical and spectroscopic methods. The IR spectra of the complexes suggest that the H3Suz behaves as a bidentate ligand. The thermal decomposition of the complexes as well as thermodynamic parameters (DeltaE*, DeltaH*, DeltaS* and DeltaG*) were estimated using Coats-Redfern and Horowitz-Metzger equations. In vitro antimicrobial activities of the H3Suz and the complexes were tested.
El-Wahed
Mohamed Gamal Abd
MG
Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt.
Refat
Moamen Salah
MS
El-Megharbel
Samy Mohamed
SM
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D002857:Chromium / Q000737:chemistry; D004055:Differential Thermal Analysis; D004926:Escherichia coli / Q000187:drug effects; D008345:Manganese / Q000737:chemistry; D008628:Mercury / Q000737:chemistry; D008670:Metals / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D012460:Sulfasalazine / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology; D013816:Thermodynamics; D014639:Vanadium / Q000737:chemistry; D015019:Yttrium / Q000737:chemistry; D015040:Zirconium / Q000737:chemistry
D000890:Anti-Infective Agents; D008670:Metals; D014639:Vanadium; D002857:Chromium; D012460:Sulfasalazine; D008345:Manganese; D015019:Yttrium; D015040:Zirconium; D008628:Mercury