title: A new cytotoxic guaianolide from Chrysanthemum boreale.
abstract: A new cytotoxic guaianolide was isolated from Chrysanthemum boreale Makino. The structure of guaianolide was elucidated as 8-acetoxy-4,10-dihydroxy-2,11(13)-guaiadiene-12,6-olide (1). Compound 1 exhibited cytotoxic activity (IC(50)< or =4 microg/ml) against all five human cancer cell lines tested.
authors.affiliation: Division of Applied Life Science (BK21 program), EB-NCRC, Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 660-701, Republic of Korea.
authors.forename: Ki Hun
authors.initials: KH
authors.lastname: Park
authors.forename: Min Suk
authors.initials: MS
authors.lastname: Yang
authors.forename: Moon Ki
authors.initials: MK
authors.lastname: Park
authors.forename: Sang Chan
authors.initials: SC
authors.lastname: Kim
authors.forename: Chae Ha
authors.initials: CH
authors.lastname: Yang
authors.forename: Sook Jahr
authors.initials: SJ
authors.lastname: Park
authors.forename: Jong Rok
authors.initials: JR
authors.lastname: Lee
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D031202:Chrysanthemum / Q000737:chemistry*; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D045789:Sesquiterpenes, Guaiane / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*
chemical_list: C539598:8-acetoxy-4,10-dihydroxy-2,11(13)-guaiadiene-12,6-olide; D000972:Antineoplastic Agents, Phytogenic; D003603:Cytotoxins; D010936:Plant Extracts; D045789:Sesquiterpenes, Guaiane