title: Anaesthetic sparing effect of local anaesthesia of the ovarian pedicle during ovariohysterectomy in dogs.
abstract: OBJECTIVE
  To evaluate the effect of local anaesthesia of the mesovarium on end-tidal isoflurane (Fe'(iso)) concentration and vital parameters during canine ovariohysterectomy.
  
  
  METHODS
  Prospective, randomized, blinded study.
  
  
  METHODS
  Twenty client-owned dogs undergoing elective ovariohysterectomy. Mean age 1.7 (+/-0.53, SD) years and mean body weight 21 kg (+/-5.9, SD).
  
  
  METHODS
  Pre-medication was with intravenous acepromazine (0.02 mg kg(-1)) and methadone (0.1 mg kg(-1)). Anaesthesia was induced with propofol and maintained with isoflurane in oxygen. One group (n = 10) received local infiltration of the mesovarium with 0.5 mL lidocaine 2% and one group (n = 10) with 0.5 mL NaCl 0.9%. Heart (HR) and respiratory rates (fr), invasive mean arterial blood pressure (MAP) and Fe'(iso)were recorded. The Fe'(iso) was adjusted according to changes in HR, RR and MAP. Time points used for comparison were T1 (after induction of anaesthesia before surgery), T2 (after lidocaine infiltration of the mesovarium) and T3 (surgical manipulation of the ovaries). Data were analysed using a mixed model for repeated measurement anova and the Tukey adjustment. Results are presented as mean +/- SD; p < 0.05 was considered significant.
  
  
  RESULTS
  In both groups, HR and fr remained stable at the three time points. Mean values ranged from 84 to 94 beats minute(-1) and from 10 to 14 breaths minute(-1). The Fe'(iso) was significantly lower at T3 compared to T1 and mean values ranged from 0.95% to 1.24%. The mean arterial blood pressure was significantly higher at T3 compared to T1 and mean values ranged from 58 to 96 mm Hg. At none of the time points were there significant differences between the two groups for HR, fr, MAP or Fe'(iso).
  
  
  CONCLUSIONS
  Neither an isoflurane sparing effect nor a difference in autonomic response to surgery was demonstrated following local anaesthesia of the mesovarium.
  
  
  CONCLUSIONS
  There appeared to be minimal benefit from local anaesthesia of the mesovarium during this study.
authors.affiliation: Clinic for Obstetrics, Gynaecology and Andrology, University of Veterinary Medicine, Veterinärplatz 1, Vienna, Austria.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Bubalo
authors.forename: Yves P S
authors.initials: YP
authors.lastname: Moens
authors.forename: Alois
authors.initials: A
authors.lastname: Holzmann
authors.forename: Paul
authors.initials: P
authors.lastname: Coppens
mesh_terms: D000772:Anesthesia, Local / Q000662:veterinary*; D000777:Anesthetics / Q000008:administration & dosage* / Q000494:pharmacology*; D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D004285:Dogs / Q000601:surgery*; D005260:Female; D007044:Hysterectomy / Q000662:veterinary*; D008012:Lidocaine / Q000494:pharmacology; D010052:Ovariectomy / Q000662:veterinary*; D010053:Ovary / Q000187:drug effects; D013997:Time Factors
chemical_list: D000777:Anesthetics; D000779:Anesthetics, Local; D008012:Lidocaine