High-dose methadone in pregnant women and its effect on duration of neonatal abstinence syndrome.
OBJECTIVE
The purpose of this study was to examine high-dose methadone in pregnant women and its effect on the duration of neonatal abstinence syndrome.


METHODS
This was a retrospective chart review of 68 neonates and their mothers who received methadone therapy during pregnancy. The last dosage of maternal methadone just before delivery and the length of treatment for neonatal abstinence syndrome were examined with an analysis of variance model.


RESULTS
When the data were analyzed for methadone dosages as a continuous variable, each 1-mg increase in the last maternal methadone dosage before delivery was associated with an additional 0.18 days of infant treatment for neonatal abstinence syndrome (P < .001; 95% CI, 0.112-0.255). In other words, every increase of 5.5 mg of methadone in the mother was associated statistically with 1 additional day of neonatal abstinence syndrome treatment for the infant. Gestational age at delivery and birthweight were not statistically significant.


CONCLUSIONS
Higher doses of maternal methadone were associated with an increase in diagnosis and longer duration of neonatal abstinence syndrome.
Lim
Susie
S
Department of Obstetrics and Gynecology, Kaiser Permanente Northwest, Beaverton, OR 97005, USA. susie.x.lim@kp.org
Prasad
Mona R
MR
Samuels
Philip
P
Gardner
Debra K
DK
Cordero
Leandro
L
D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D015331:Cohort Studies; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008691:Methadone / Q000008:administration & dosage* / Q000009:adverse effects*; D009357:Neonatal Abstinence Syndrome / Q000209:etiology*; D010634:Phenobarbital / Q000627:therapeutic use; D011247:Pregnancy; D011256:Pregnancy Outcome; D012044:Regression Analysis; D012189:Retrospective Studies
D000927:Anticonvulsants; D008691:Methadone; D010634:Phenobarbital