title: Genome-widely significant evidence of linkage of schizophrenia to chromosomes 2p24.3 and 6q27 in an SNP-Based analysis of Korean families.
abstract: The present study reports the results of a genome-wide SNP linkage scan for schizophrenia in the Korean population. Fifty-six multiplex schizophrenia families were analyzed. Clinical evaluations on all subjects were consistently performed by raters in a single research team. Multipoint non-parametric linkage analysis was performed, and empirical simulations were generated to determine genome-wide significance. The authors found genome-widely significant evidence of linkage for schizophrenia to chromosomes 2p24.3 (NPL Z = 3.18) and 6q27 (NPL Z = 2.90). Six other chromosomal regions, that is, 3q24, 13q12.3, 18q22.3, 20p12.2, 4p14, and 1p36.12, yielded NPL Z scores of above 2.0 for either broad or narrow phenotype classes. Although linkage to these loci has not received prominent attention in studies on Caucasian families, multiple overlaps were observed between our loci (on 2p, 3q, and 13q) and linkage peaks generated from extended families in various isolated populations. Fine mappings and the detection of candidate genes within these regions are warranted.
authors.affiliation: Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Kangnam-Gu, Seoul, South Korea.
authors.forename: Kyung Sue
authors.initials: KS
authors.lastname: Hong
authors.forename: Hong-Hee
authors.initials: HH
authors.lastname: Won
authors.forename: Eun-Young
authors.initials: EY
authors.lastname: Cho
authors.forename: Hyun Ok
authors.initials: HO
authors.lastname: Jeun
authors.forename: Sang-Seon
authors.initials: SS
authors.lastname: Cho
authors.forename: Yu-Sang
authors.initials: YS
authors.lastname: Lee
authors.forename: Dong Yeon
authors.initials: DY
authors.lastname: Park
authors.forename: Yong Lee
authors.initials: YL
authors.lastname: Jang
authors.forename: Kyeong-Sook
authors.initials: KS
authors.lastname: Choi
authors.forename: Dongsoo
authors.initials: D
authors.lastname: Lee
authors.forename: Min-Ji
authors.initials: MJ
authors.lastname: Kim
authors.forename: Seonwoo
authors.initials: S
authors.lastname: Kim
authors.forename: Wou Sang
authors.initials: WS
authors.lastname: Han
authors.forename: Jong-Won
authors.initials: JW
authors.lastname: Kim
mesh_terms: D002874:Chromosome Mapping / Q000379:methods; D002889:Chromosomes, Human, Pair 2; D002896:Chromosomes, Human, Pair 6; D004252:DNA Mutational Analysis / Q000379:methods; D005190:Family; D005787:Gene Frequency; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D007723:Korea; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*