C2-symmetric bis-hydrazones as ligands in the asymmetric Suzuki-Miyaura cross-coupling.
Glyoxal bis-hydrazone derived from (S,S)-1-amino-2,5-diphenylpyrrolidine behaves as an excellent ligand for phosphine-free, asymmetric Suzuki-Miyaura cross couplings, thereby affording a variety of enantiomerically enriched biaryls with different substitution patterns. The high catalytic activity of the [PdCl2(bis-hydrazone)] complex allows reactions to be performed at room temperature, affording products with excellent enantioselectivities in all cases.
Bermejo
Antonio
A
Departamento de Química Orgánica, Universidad de Sevilla, Apartado de Correos 1203, 41071 Seville, Spain.
Ros
Abel
A
Fernández
Rosario
R
Lassaletta
José M
JM