title: Factors associated with impaired quality of life in younger and older adults with epilepsy.
abstract: The purpose of this study is to weigh psychological state, patients' demographics, seizure-related factors, and medical comorbidity in older adults with epilepsy against the same parameters in younger adults in an attempt to identify best quality of life (QoL) predictors. The Quality of Life in Epilepsy Inventory for Adults (QOLIE-31) and the Beck Depression Inventory-II (BDI-II) were completed by 146 patients with localization-related epilepsy. There was no statistical difference in the QOLIE-31 total score between younger and older adults. Best QoL predictors were BDI-II and seizure frequency, with BDI-II providing more than 3 times the impact of seizure frequency. BDI-II also substantively predicted most QOLIE-31 domains. Additionally, epilepsy duration positively correlated with overall QoL only among older adults. In summary, in younger as well as older adult epilepsy patients, depressive symptoms emerge as the strongest predictor of QoL. However, older adults appear to adapt better to their chronic health problem.
authors.affiliation: Department of Clinical Neuroscience and Psychiatry, Osaka University Graduate School of Medicine, Japan.
authors.forename: Leonides
authors.initials: L
authors.lastname: Canuet
authors.forename: Ryouhei
authors.initials: R
authors.lastname: Ishii
authors.forename: Masao
authors.initials: M
authors.lastname: Iwase
authors.forename: Koji
authors.initials: K
authors.lastname: Ikezawa
authors.forename: Ryu
authors.initials: R
authors.lastname: Kurimoto
authors.forename: Michiyo
authors.initials: M
authors.lastname: Azechi
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Takahashi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nakahachi
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Teshima
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Takeda
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D003627:Data Interpretation, Statistical; D003863:Depression / Q000523:psychology; D004827:Epilepsy / Q000453:epidemiology* / Q000523:psychology*; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life; D012640:Seizures / Q000523:psychology