Diversity of glutathione s-transferase omega 1 (a140d) and 2 (n142d) gene polymorphisms in worldwide populations.
1. Glutathione S-transferase class omega (GSTO) 1 and 2 are members of the glutathione-S-transferase family, which uses glutathione in the process of the biotransformation of drugs, xenobiotics and oxidative stress. Associations with the age-at-onset of Alzheimer's and Parkinson's diseases have been shown in the genetic polymorphism of GSTO1 and GSTO2. 2. In the present study, the frequencies of GSTO1*A140D and GSTO2*N142D in Ovambos (n = 163), Turks (n = 194), Mongolians (n = 243) and Japanese (n = 102) were investigated and compared with findings from other studies. Detection of these single nucleotide polymorphisms was performed by polymerase chain reaction-restriction fragment length polymorphism analysis. 3. The allele frequencies of these polymorphisms in Ovambos, Turks, Mongolians and Japanese were 0.040, 0.085, 0.128 and 0.108, respectively, for GSTO1*A140D and 0.583, 0.219, 0.173 and 0.216, respectively, for GSTO2*N142D. Ovambos showed the lowest allele frequency of GSTO1*A140D. Conversely, Africans, including Ovambos, showed higher allele frequencies of GSTO2*N142D than Caucasians and Asians. 4. The existence of a certain genetic heterogeneity in the worldwide distribution of these two polymorphisms is revealed in the present study.
Takeshita
Haruo
H
Department of Legal Medicine, Shimane University School of Medicine, Izumo, Shimane, Japan. htakeshi@med.shimane-u.ac.jp
Fujihara
Junko
J
Takastuka
Hisakazu
H
Agusa
Tetsuro
T
Yasuda
Toshihiro
T
Kunito
Takashi
T
D044466:Asian People / Q000235:genetics; D044383:Black People / Q000235:genetics; D005787:Gene Frequency; D005828:Genetics, Population; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007564:Japan; D008986:Mongolia; D009276:Namibia; D020641:Polymorphism, Single Nucleotide; D014421:Turkey; D044465:White People / Q000235:genetics
C490476:GSTO1 protein, human; C492569:GSTO2 protein, human; D005982:Glutathione Transferase