title: Simultaneous determination of amoxycillin and dicloxacillin in capsules by potentiometric titrimetry and high-performance liquid chromatography.
abstract: Direct potentiometric titration and two HPLC conditions for the simultaneous determination of amoxycillin and dicloxacillin in their capsules have been developed. One-run titration utilizing 0.05M acet. HClO(4) enables the quantification of both antibiotics. The HPLC-separation could be undertaken on reversed phase, LiChrosorb RP-18 (10 mum), and LiChrospher 100 RP-18 (5 mum), columns by using mobile phases containing acetonitrile + 1% aq, acetic acid, in proportions of 47:53 or 39:61 (v/v), respectively, at a flow rate of 1.5 ml/min with UV-detection at 240 nm. Recoveries of the individual drugs by the application of each described method were found to be fairly satisfactory.
authors.affiliation: Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh-11451, Saudi Arabia.
authors.forename: E M
authors.initials: EM
authors.lastname: Abdel-Moety
authors.forename: M A
authors.initials: MA
authors.lastname: Abounassif
authors.forename: el-R A
authors.initials: el-RA
authors.lastname: Gad-Kariem
authors.forename: N A
authors.initials: NA
authors.lastname: Khattab