title: Phosphoinositides and the endocytic pathway.
abstract: Phosphorylation of the phosphatidylinositol headgroup generates seven varieties of phosphoinositide of which PtdIns(4,5)P(2), PtdIns3P and PtdIns (3,5)P(2) have established roles on the endocytic pathway. In this review, we discuss the enzymes responsible for generation and turnover of these lipids, which are keys to determining compartmental identity and the flux of material through the endocytic system. The enzymatic generation of lipids serves as an amplification mechanism through which a wide variety of effector molecules can be recruited.
authors.affiliation: Physiological Laboratory, School of Biomedical Sciences, Liverpool L693BX, UK. clague@liv.ac.uk
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Clague
authors.forename: Sylvie
authors.initials: S
authors.lastname: Urbé
authors.forename: Jane
authors.initials: J
authors.lastname: de Lartigue
mesh_terms: D000818:Animals; D022163:Clathrin-Coated Vesicles / Q000502:physiology*; D004705:Endocytosis / Q000502:physiology*; D006801:Humans; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D018129:Phosphatidylinositol Phosphates / Q000502:physiology; D010716:Phosphatidylinositols / Q000502:physiology*; D010766:Phosphorylation; D021381:Protein Transport / Q000502:physiology
chemical_list: D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols; C106336:phosphatidylinositol 3,5-diphosphate; C055525:phosphatidylinositol 3-phosphate; D019869:Phosphatidylinositol 3-Kinases