[The association of tyrosine hydroxylase gene polymorphism with mental disorder].
OBJECTIVE
To evaluate the relationship between the tyrosine hydroxylase (TH) gene and mental disorder by comparing the two TH gene SNP points (extron 3 and intron 9) of patients with mental disorders and normal human.


METHODS
DNA extracted from specimens of patients and normal subjects were quantified by using Real-time PCR.


RESULTS
(1) G334A distribution was: G=0.133, A=0.867 in patients with schizophrenia, G=0.116, A=0.884 in patients with depression, and G=0.214, A=0.786 in normal group. (2) C5162G distribution was: C=0.962, G=0.038 in patients with schizophrenia, C=0.959, G=0.041 in patients with depression, and C=0.961, G=0.039 in normal group.


CONCLUSIONS
There are statistically significant differences in G334A locus between normal people and patients with mental disorders, but no statistically significant differences in C5162G locus.
Yu
Jian
J
School of Forensic Medicine, China Medical University, Shenyang 110001, China. yujian0905@sina.com
Pang
Hao
H
Wang
Bao-Jie
BJ
D003866:Depressive Disorder / Q000201:enzymology / Q000235:genetics; D005260:Female; D053803:Forensic Genetics; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000201:enzymology* / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012559:Schizophrenia / Q000201:enzymology / Q000235:genetics; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics*
D014446:Tyrosine 3-Monooxygenase