Intraneural reticular perineurioma of the hypoglossal nerve.
BACKGROUND
Intraneural perineurioma or reticular perineurioma, which is 1 variant of extraneural perineurioma, has been rarely reported in the head and neck region.


METHODS
We report a case of a 52-year-old woman who wasseen with a swelling in the neck. A mass was found located on the medial aspect of the left submandibular gland and was palpated with a sponge-like texture. The mass was seen as a homogenous semisolid lesion on CT and ultrasound examination.


RESULTS
Surgical exploration revealed expansion of the hypoglossal nerve. Microscopically, the tumor showed both pseudo-onion bulb, which is a feature of intraneural perineurioma, and reticular pattern with microcysts, which is a feature of reticular variant of extraneural perineurioma. The tumor cells were immunopositive for epithelial membrane antigen and human erythrocyte glucose transporter-1 (GLUT-1).


CONCLUSIONS
An intraneural reticular perineurioma of the hypoglossal nerve should be included in the differential diagnosis of submandibular swelling.
Kum
Yoon Seup
YS
Department of Pathology, School of Medicine, Catholic University of Daegu, Daegu, South Korea.
Kim
Jeong Kyu
JK
Cho
Chang Ho
CH
Kim
Ho Kyun
HK
D001707:Biopsy, Needle; D003390:Cranial Nerve Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D005260:Female; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D007002:Hypoglossal Nerve / Q000473:pathology*; D007150:Immunohistochemistry; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D018317:Nerve Sheath Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D013363:Submandibular Gland / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed; D018608:Ultrasonography, Doppler