title: Melatonin analogue new indole hydrazide/hydrazone derivatives with antioxidant behavior: synthesis and structure-activity relationships.
abstract: Melatonin (MLT) is a hormone produced in the brain by the pineal gland, from the amino acid tryptophan. It is also an antioxidant hormone with a particular role in the protection of nuclear and mitochondrial DNA. In recent years, many physiological properties of MLT have been described resulting in much attention in the development of synthetic compounds possessing the indole ring. Sixteen MLT analogue indole hydrazide/hydrazone derivatives were synthesized and in vitro antioxidant activity was investigated. Most of the compounds showed significantly higher activity than MLT at 10(-3) M and 10(-4) M concentrations.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandogan, Ankara, Turkey.
authors.forename: Gökce
authors.initials: G
authors.lastname: Gürkök
authors.forename: Tulay
authors.initials: T
authors.lastname: Coban
authors.forename: Sibel
authors.initials: S
authors.lastname: Suzen
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry / Q000378:metabolism; D006835:Hydrazones / Q000737:chemistry* / Q000494:pharmacology*; D007211:Indoles / Q000737:chemistry; D015227:Lipid Peroxidation; D008550:Melatonin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D010851:Picrates / Q000737:chemistry / Q000378:metabolism; D010870:Pineal Gland / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D013481:Superoxides / Q000737:chemistry / Q000378:metabolism
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D006835:Hydrazones; D007211:Indoles; D010851:Picrates; D013481:Superoxides; C004931:1,1-diphenyl-2-picrylhydrazyl; D008550:Melatonin