title: Renal outcome following on- and off-pump coronary artery bypass graft surgery.
abstract: A prospective study was carried out to compare the outcomes of patients with preexisting non-dialysis-dependent renal dysfunction who underwent coronary artery bypass grafting with or without cardiopulmonary bypass. Elective off-pump coronary artery bypass was performed in 29 patients with renal dysfunction. Their results were compared with those of a similar group of 35 patients who underwent the conventional on-pump coronary artery grafting. There was a significant deterioration in creatinine clearance in the on-pump group on days 1, 2, and 4 after surgery, while creatinine clearance in the off-pump group remained close to the baseline level. Both groups had improved to the preoperative creatinine clearance values on follow-up at 4 weeks. It was concluded that off-pump surgery provided better renal protection than the conventional on-pump technique in patients with preexisting non-dialysis-dependent renal dysfunction.
authors.affiliation: Division of Cardiothoracic Anesthesia, Heart and Lung Center, Hospital University Kebangsaan Malaysia, University Kebangsaan Malaysia, Kuala Lumpur, Malaysia. joanna@mail.hukm.ukm.my
authors.forename: Joanna S M
authors.initials: JS
authors.lastname: Ooi
authors.forename: Mohd R
authors.initials: MR
authors.lastname: Abdul Rahman
authors.forename: Shamsul A
authors.initials: SA
authors.lastname: Shah
authors.forename: Mohd Z
authors.initials: MZ
authors.lastname: Dimon
mesh_terms: D000368:Aged; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D047549:Coronary Artery Bypass, Off-Pump / Q000009:adverse effects*; D003324:Coronary Artery Disease / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007674:Kidney Diseases / Q000150:complications* / Q000503:physiopathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D003404:Creatinine