title: NFIX--one gene, two knockouts, multiple effects.
abstract: A previous knockout of the transcription factor gene nuclear factor IX (NFIX) in mice produced impaired development of the corpus callosum and severe skeletal defects. A recent paper in BMC Developmental Biology reports an apparently similar NFIX knockout that produced marked differences in phenotype, raising intriguing general questions about the possible causes of such differences in mouse knockouts.
authors.affiliation: Center of Regenerative Medicine in Barcelona, Doctor Aiguader 88, 08003 Barcelona, Spain.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Pekarik
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Izpisua Belmonte
mesh_terms: D061085:Agenesis of Corpus Callosum; D000818:Animals; D001842:Bone and Bones / Q000002:abnormalities*; D020868:Gene Silencing; D006849:Hydrocephalus / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout; D051839:NFI Transcription Factors / Q000235:genetics*; D010012:Osteogenesis
chemical_list: D051839:NFI Transcription Factors; C497650:Nfix protein, mouse