Differential electrolytic potentiometric titration method for the determination of ciprofloxacin in drug formulations.
A simple and rapid differential electrolytic potentiometric titration method for the determination of ciprofloxacin was developed. The work is based on the fast complexation reaction between iron(III) and ciprofloxacin in a ratio of 1:3, respectively, in sulfuric acid media of 0.09 mol dm(-3). Among the electrodes tested silver amalgam electrodes were found to be a suitable indicating system. By applying a current density of 0.5 muA cm(-2) to these electrodes and using iron(III) solution of 0.097 mol dm(-3) as a titrant, normal titration curves were obtained. The method was successfully applied for the determination of ciprofloxacin in drug formulations as low as 4.0 ppm.
Abulkibash
Abdalla M
AM
Chemistry Department, King Fahd University of Petroleum and Minerals, KFUPM, P.O. Box 1726, Dhahran 31261, Saudi Arabia.
Sultan
Salah M
SM
Al-Olyan
Abeer M
AM
Al-Ghannam
Sheikha M
SM