title: Spectrophotometric methods for the determination of prazosin hydrochloride in tablets.
abstract: Four simple and sensitive methods for the assay of prazosin hydrochloride (PRH) are developed. These methods are based on the formation of coloured species by treating it either with excess N-bromosuccinimide (NBS) and determining the unconsumed NBS with p-N-methyl aminophenol sulphate (metol)-sulphanilamide (SA) reagent (method A, lambda(max) 520 nm): with 3-methyl-2-benzothiazolinone hydrazone hydrochloride (MBTH) in the presence of eerie ammonium sulphate (CAS) (method B, lambda(max) 620 nm) or with acidic dyes such as orange-II (O-II) (method C, lambda(max) 490 nm) and alizarin violet 3B (AV-3B) (method D, lambda(max) 570 nm) under the specified experimental conditions. Regression analysis of Beer's law plot showed good correlation in the concentration range of 1.0-10.0, 2.5-25.0, 1.0-17.5 and 2.5-30.0 mug ml for methods A, B, C and D respectively.
authors.affiliation: Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003, India.
authors.forename: K
authors.initials: K
authors.lastname: Sreedhar
authors.forename: C S
authors.initials: CS
authors.lastname: Sastry
authors.forename: M
authors.initials: M
authors.lastname: Narayana Reddy
authors.forename: D G
authors.initials: DG
authors.lastname: Sankar