title: Cardiovascular disease in patients with hemophilia.
abstract: Mortality due to ischemic heart disease in hemophilia patients is lower as compared to the general male population. Differences in the prevalence of cardiovascular risk factors cannot explain this finding. The hypocoagulable state of hemophilia patients might have a protective effect on thrombus formation, which precipitates infarction. It remains unclear whether the deficiency of coagulation factor VIII or IX exerts a protective effect on the development of atherosclerosis. Despite the relative protection against cardiovascular events, the incidence of ischemic cardiovascular disease in hemophilia patients is increasing, because life expectancy of these patients now approaches that of the general population. This review focuses on what is currently known about cardiovascular risk factors, atherosclerosis, arterial thrombosis and ischemic cardiovascular disease in hemophilia patients.
authors.affiliation: Van Creveldkliniek/Department of Haematology, University Medical Center Utrecht, The Netherlands. a.tuinenburg-2@umcutrecht.nl
authors.forename: A
authors.initials: A
authors.lastname: Tuinenburg
authors.forename: E P
authors.initials: EP
authors.lastname: Mauser-Bunschoten
authors.forename: M C
authors.initials: MC
authors.lastname: Verhaar
authors.forename: D H
authors.initials: DH
authors.lastname: Biesma
authors.forename: R E G
authors.initials: RE
authors.lastname: Schutgens
mesh_terms: D050197:Atherosclerosis; D002318:Cardiovascular Diseases / Q000209:etiology*; D006467:Hemophilia A / Q000150:complications*; D002836:Hemophilia B / Q000150:complications; D006801:Humans; D015994:Incidence; D012307:Risk Factors; D013927:Thrombosis