[Dermatological side effects during therapy with serotonin noradrenaline reuptake inhibitors].
Bleeding complications during therapy with serotonin norepinephrine reuptake inhibitors are a well-known phenomenon. We report a patient who developed ecchymosis during administration of duloxetine. As a correlate we detected a transient platelet dysfunction. After converting to venlafaxine therapy, another antidepressant with a dual mechanism of action, the patient showed normal platelet function. We finally achieved remission of the episode.
Gross
C M
CM
Abteilung für Psychiatrie und Psychotherapie, Universitätsklinikum Freiburg, Hauptstrasse 5, 79104, Freiburg, Germany. claus.michael.gross@uniklinik-freiburg.de
Klöcker
M
M
Jakob
T
T
Klecha
D
D
D003875:Drug Eruptions / Q000175:diagnosis* / Q000209:etiology*; D000068736:Duloxetine Hydrochloride; D004438:Ecchymosis / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D006801:Humans; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use*; D013876:Thiophenes / Q000009:adverse effects* / Q000627:therapeutic use*; D055815:Young Adult
D000068736:Duloxetine Hydrochloride; D017367:Selective Serotonin Reuptake Inhibitors; D013876:Thiophenes