Determination of isoniazid in drugs.
A titrimetric method is described for the determination of isoniazid in pharmaceutical preparations. Samples are treated with an excess of iodine monochloride, and the iodine produced is titrated with iodine trichloride to an Andrews end-point. p-Aminosalicylic acid undergoes only nuclear iodination and does not interfere. Mixtures of isoniazid with vitamin C or methionine are analysed by first titrating both compounds by the Andrews method and then determining either vitamin C alone by titration with iodine monochloride or methionine by a second Andrews titration after destruction of isoniazid with nitrous acid. In both cases, isoniazid is obtained by difference. A mixture of isoniazid, methionine and vitamin C can also be analysed.
Verma
K K
KK
Department of Chemistry, University of Jabalpur, Jabalpur 482001, India.
Gupta
A K
AK