Prostatic Zn determination for prostate cancer diagnosis.
We present our studies of prostatic Zn concentration measurements, carried out in the light of a novel prostate cancer (CAP) diagnosis method proposed by us. The method is based on in vivo prostatic Zn mapping by XRF trans-rectal probe. We report on the extensive clinical studies, intended to assess the validity of the novel proposed diagnostic method. Zn content was measured in vitro in needle-biopsy samples from several hundreds of patients, and was correlated with histological findings and other patient parameters. For this purpose, a technique of absolute Zn content determination in approximately 1mm(3) fresh tissue samples by XRF was developed. The experimental details and the main clinical-evaluation results are presented. We further outline the suggested design of the XRF trans-rectal probe for an efficient in vivo detection and mapping of the Zn fluorescence radiation from the prostate through the rectal wall. Laboratory phantom studies, a preliminary design concept and its expected performance are also reported.
Shilstein
S Sh
SSh
Department of Particle Physics, Weizmann Institute of Science, POB 26, Rehovot 76100, Israel.
Cortesi
M
M
Breskin
A
A
Chechik
R
R
Vartsky
D
D
Raviv
G
G
Kleinman
N
N
Ramon
J
J
Kogan
G
G
Gladysh
V
V
Moriel
E
E
Huszar
M
M
Volkov
A
A
Fridman
E
E