title: Tadalafil in the management of severe pulmonary artery hypertension.
abstract: Severe oyknibart arterial hypertension is a life-threatening disease with a poor prognosis. Continuous intravenous infusion of prostacyclin has proved effective in this condition. However, it carries the risk of serious complications arising from the complex delivery system along with a high cost. Prostacyclin analogs, endothelin antagonists, and the phophodiesterase-5 inhibitor sildenafil are emerging and promisinge therapies. Tadalafil, like sildenafil, is a selective phosphodiesterase-5 inhibitor with a longer duration of action. We repport the use of tadalafil in two patients of severe pulmonary arterial hypertension who could not afford expensive treatment.
authors.affiliation: Department of Medicine and Cardiology, Regional Institute of Medical Sciences, Imphal.
authors.forename: Thokchom Sd
authors.initials: TS
authors.lastname: Singh
authors.forename: Dilip
authors.initials: D
authors.lastname: Kumar
authors.forename: Soumik
authors.initials: S
authors.lastname: Basu
authors.forename: Manotosh
authors.initials: M
authors.lastname: Panja
authors.forename: Bishwanath
authors.initials: B
authors.lastname: Mitra