Intramolecular hydrogen-bonding in beta adrenergic blocking agents.
The acid dissociation constants for nine beta-adrenergic blocking agents have been determined. Their unusually low pK(a), values are explained as being due to the formation of an intramolecular hydrogen bond, between the terminal amino group and the beta-hydroxyl group on the alkanolamine side-chain which is common to this class of drugs.
Laxer
M
M
Department of Pharmaceutics, School of Pharmacy, University of Georgia, Athens, Georgia 30602, U.S.A.
Capomacchia
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AC
Hardee
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GE