title: Effect of a phyto-compound on delayed gastric emptying in functional dyspepsia: a randomized-controlled study.
abstract: OBJECTIVE
  The aim of the present study was to assess the efficacy of a hydro-alcoholic solution of a phytocompound based on Gentianae, Cinchonae, Absinthii and Cinnamomi on gastric emptying in Helicobacter pylori-negative dyspeptic patients.
  
  
  METHODS
  The study group consisted of 24 patients with a diagnosis of long-standing dismotility-like functional dyspepsia. All patients were devoid of any major past or ongoing disease and dyspepsia-associated diseases were excluded. After a 2-week wash out period, the patients were randomized to a 2-week treatment in which they were given 20 gtt of the compound 30 min before meals. At the beginning and end of the study, a gastric emptying test was performed by a paracetamol absorption test using a standard meal. The global symptom index (GSI) was assessed daily by a validated questionnaire.
  
  
  RESULTS
  Treatment with the phytocompound significantly improved the gastric emptying test (P < 0.01) which was delayed in dyspeptic patients as well as GSI (P < 0.05).
  
  
  CONCLUSIONS
  This phytocompound might be an effective therapeutic option in the treatment of dismotility-like dyspepsia.
authors.affiliation: TMC Hospital, Shizuoka, Japan.
authors.forename: Yussef
authors.initials: Y
authors.lastname: Metugriachuk
authors.forename: Francesco
authors.initials: F
authors.lastname: Marotta
authors.forename: Ojime
authors.initials: O
authors.lastname: Kuroi
authors.forename: Junji
authors.initials: J
authors.lastname: Tsuchiya
authors.forename: Khean-Lee
authors.initials: KL
authors.lastname: Goh
authors.forename: Emilio
authors.initials: E
authors.lastname: Minelli
authors.forename: Satoru
authors.initials: S
authors.lastname: Kawakita
mesh_terms: D000082:Acetaminophen / Q000493:pharmacokinetics; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000493:pharmacokinetics; D004415:Dyspepsia / Q000188:drug therapy* / Q000503:physiopathology*; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal
chemical_list: D018712:Analgesics, Non-Narcotic; D010936:Plant Extracts; D000082:Acetaminophen