Complexometric-spectrophotometric assay of tetracyclines in drug formulations.
An accurate, rapid and very simple spectrophotometric method for the assay of tetracyclines (tetracycline.HCl, chlorotetracycline.HCl, demeclocycline, oxytetracycline.HCl and doxycycline) has been developed. The method is based on the complexation of iron(III) with tetracyclines in 0.001M sulphuric acid. It has been successfully applied to the assay of tetracyclines in drug formulations, and the interferences of excipients have been examined. The results have been statistically compared with those obtained by two standard methods and found to be very satisfactory.
Sultan
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Chemistry Department, College of Science, King Saud University, Riyadh 11451, P.O. Box 2455, Saudi Arabia.
Alzamil
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Alarfaj
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