title: Loss of Bmx nonreceptor tyrosine kinase prevents pressure overload-induced cardiac hypertrophy.
abstract: Bmx nonreceptor tyrosine kinase has an established role in endothelial and lymphocyte signaling; however, its role in the heart is unknown. To determine whether Bmx participates in cardiac growth, we subjected mice deficient in the molecule (Bmx knockout mice) to transverse aortic constriction (TAC). In comparison with wild-type mice, which progressively developed massive hypertrophy following TAC, Bmx knockout mice were resistant to TAC-induced cardiac growth at the organ and cell level. Loss of Bmx preserved cardiac ejection fraction and decreased mortality following TAC. These findings are the first to demonstrate a necessary role for the Tec family of tyrosine kinases in the heart and reveal a novel regulator (Bmx) of pressure overload-induced hypertrophic growth.
authors.affiliation: Department of Anesthesiology, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA.
authors.forename: Scherise A
authors.initials: SA
authors.lastname: Mitchell-Jordan
authors.forename: Tanja
authors.initials: T
authors.lastname: Holopainen
authors.forename: Shuxun
authors.initials: S
authors.lastname: Ren
authors.forename: Sujing
authors.initials: S
authors.lastname: Wang
authors.forename: Sarah
authors.initials: S
authors.lastname: Warburton
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Zhang
authors.forename: Kari
authors.initials: K
authors.lastname: Alitalo
authors.forename: Yibin
authors.initials: Y
authors.lastname: Wang
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Vondriska
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000235:genetics / Q000502:physiology*; D006332:Cardiomegaly / Q000235:genetics / Q000378:metabolism* / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D011505:Protein-Tyrosine Kinases / Q000172:deficiency* / Q000235:genetics / Q000502:physiology
chemical_list: C492366:Bmx protein, mouse; D011505:Protein-Tyrosine Kinases