Successful treatment of disseminated Acanthamoeba sp. infection with miltefosine.
We report on an HIV-negative but immunocompromised patient with disseminated acanthamoebiasis, granulomatous, amoebic encephalitis and underlying miliary tuberculosis and tuberculous meningitis. The patient responded favorably to treatment with miltefosine, an alkylphosphocholine. The patient remained well with no signs of infection 2 years after treatment cessation.
Aichelburg
Alexander C
AC
Pulmonological Centre, Otto Wagner Hospital, Vienna, Austria. alexander.aichelburg@wienkav.at
Walochnik
Julia
J
Assadian
Ojan
O
Prosch
Helmut
H
Steuer
Andrea
A
Perneczky
Gedeon
G
Visvesvara
Govinda S
GS
Aspöck
Horst
H
Vetter
Norbert
N
D000048:Acanthamoeba; D000284:Administration, Oral; D000287:Administration, Topical; D000328:Adult; D000562:Amebiasis / Q000150:complications / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004660:Encephalitis / Q000150:complications / Q000276:immunology / Q000473:pathology; D006099:Granuloma / Q000150:complications / Q000276:immunology / Q000473:pathology; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D010767:Phosphorylcholine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012883:Skin Ulcer / Q000150:complications / Q000276:immunology / Q000473:pathology; D016896:Treatment Outcome; D014391:Tuberculosis, Miliary / Q000150:complications / Q000276:immunology / Q000473:pathology
D000981:Antiprotozoal Agents; D010767:Phosphorylcholine; C039128:miltefosine