Influence of paternal age on assisted reproduction outcome.
There has been an increasing tendency to delay parenthood in developed countries in recent years, and there is not enough information available regarding the effect of this on fertility. The aim of this work was to determine the role of paternal age on the outcome of assisted reproduction. A retrospective study was designed comprising a total of 2204 intrauterine insemination (IUI) cycles, 1286 IVF cycles and 1412 IVF cycles with donated oocytes during the period 2000 to 2006. Male mean age was 34.3 years (range 25-56) for IUI, 34.8 years (range 19-62) for IVF and 41.10 years (range 25-71) for ovum donation cycles. Statistics revealed no differences regarding pregnancy and miscarriage rates when the results were compared among age groups. In standard IVF and ovum donation cycles there was no clear association between embryo quality and paternal age. There was no significant relationship between male age and implantation rate. So far this is the largest study concerning the relevance of male age in assisted reproduction. As confirmed by the present data, the effect of the age of the male in the range studied is irrelevant. This finding contributes to the information that can be provided to infertile couples.
Bellver
Jose
J
Instituto Valenciano de Infertilidad, Plaza de la Policía Local, 3, Valencia 46015, Spain. jbellver@ivi.es
Garrido
Nicolas
N
Remohí
Jose
J
Pellicer
Antonio
A
Meseguer
Marcos
M
D000328:Adult; D000368:Aged; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007317:Insemination, Artificial, Homologous; D008297:Male; D008875:Middle Aged; D018587:Oocyte Donation; D010331:Paternal Age; D011247:Pregnancy; D011256:Pregnancy Outcome; D011379:Prognosis; D027724:Reproductive Techniques, Assisted; D012189:Retrospective Studies; D013076:Sperm Count; D013081:Sperm Motility; D055815:Young Adult