Hydrogen peroxide reduces lead-induced oxidative stress to mouse brain and liver.
Lead (Pb) intoxication may initiate many disorders in human and animals. This study investigates the role of exogenous hydrogen peroxide (H(2)O(2)) in inducing mouse tolerance to Pb exposure. Results showed that the simultaneous application of 1.2 microg H(2)O(2) per kg body weight efficiently protected mice against the Pb-caused injury, as revealed by decreased growth suppression caused by the Pb stress, increased antioxidative enzyme activity, reduced lipid peroxidation, and the protective effect on the nuclear DNA integrity. To our knowledge, this is the first finding of this sort.
Li
R G
RG
Department of Biology, Shenyang Normal University, Shenyang 110034, People's Republic of China.
Li
T T
TT
Hao
L
L
Xu
X
X
Na
J
J
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D004247:DNA / Q000032:analysis; D004249:DNA Damage / Q000187:drug effects; D004195:Disease Models, Animal; D004587:Electrophoresis, Agar Gel; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D007855:Lead Poisoning / Q000378:metabolism / Q000517:prevention & control*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000737:chemistry / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051379:Mice; D009942:Organometallic Compounds / Q000633:toxicity*; D016877:Oxidants / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D010088:Oxidoreductases / Q000187:drug effects / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D009942:Organometallic Compounds; D016877:Oxidants; D017392:Thiobarbituric Acid Reactive Substances; D004247:DNA; D006861:Hydrogen Peroxide; D010088:Oxidoreductases; C008261:lead acetate