Deprotonative cadmation of functionalized aromatics.
This communication describes the deproto-metalation of a large range of aromatics including heterocycles using a newly developed lithium-cadmium base; the reaction proceeds at room temperature with an excellent chemoselectivity and efficiency, and proved to be regioselective in most cases.
L'Helgoual'ch
Jean-Martial
JM
Chimie et Photonique Moléculaires, UMR 6510 CNRS, Université de Rennes 1, Campus Scientifique de Beaulieu, Rennes Cedex, France.
Bentabed-Ababsa
Ghenia
G
Chevallier
Floris
F
Yonehara
Mitsuhiro
M
Uchiyama
Masanobu
M
Derdour
Aïcha
A
Mongin
Florence
F
D001555:Benzene Derivatives / Q000737:chemistry*; D002104:Cadmium / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000138:chemical synthesis* / Q000737:chemistry; D008094:Lithium / Q000737:chemistry*; D008956:Models, Chemical; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D011522:Protons; D013237:Stereoisomerism; D013696:Temperature
D001555:Benzene Derivatives; D006571:Heterocyclic Compounds; D006846:Hydrocarbons, Halogenated; D009942:Organometallic Compounds; D011522:Protons; D002104:Cadmium; D008094:Lithium