title: Downstream from calcium signalling: mitochondria, vacuoles and pancreatic acinar cell damage.
abstract: Ca(2+) is one of the most ancient and ubiquitous second messengers. Highly polarized pancreatic acinar cells serve as an important cellular model for studies of Ca(2+) signalling and homeostasis. Downstream effects of Ca(2+) signalling have been and continue to be an important research avenue. The primary functions regulated by Ca(2+) in pancreatic acinar cells--exocytotic secretion and fluid secretion--have been defined and extensively characterized in the second part of the last century. The role of cytosolic Ca(2+) in cellular pathology and the related question of the interplay between Ca(2+) signalling and bioenergetics are important current research lines in our and other laboratories. Recent findings in these interwoven research areas are discussed in the current review.
authors.affiliation: Physiological Laboratory, University of Liverpool, Liverpool, UK.
authors.forename: S
authors.initials: S
authors.lastname: Voronina
authors.forename: M
authors.initials: M
authors.lastname: Sherwood
authors.forename: S
authors.initials: S
authors.lastname: Barrow
authors.forename: N
authors.initials: N
authors.lastname: Dolman
authors.forename: A
authors.initials: A
authors.lastname: Conant
authors.forename: A
authors.initials: A
authors.lastname: Tepikin
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D008928:Mitochondria / Q000502:physiology*; D010179:Pancreas / Q000166:cytology*; D014617:Vacuoles / Q000502:physiology*
chemical_list: D002118:Calcium