Aromatase inhibitors prevent the estrogen rise associated with the flare effect of gonadotropins in patients treated with GnRH agonists.
This was a preliminary study to determine the effect of aromatase inhibitors in preventing the flare induced by GnRH agonist (GnRH-a) in women with endometriosis (n = 9) or leiomyomata (n = 4) who were given letrozole on the first 5 days of the GnRH-a therapy. Serum LH and FSH levels showed the typical flare 1 day after the injection of the GnRH-a; however, E(2) declined immediately after letrozole administration and was notably suppressed at 1, 2, and 4 days after GnRH-a. No patients complained of clinical symptoms typical of the GnRH-a flare phenomenon.
Bedaiwy
Mohamed A
MA
Reproductive Research Center, Cleveland Clinic, Cleveland, Ohio, USA.
Mousa
Noha A
NA
Casper
Robert F
RF
D000328:Adult; D047072:Aromatase Inhibitors / Q000494:pharmacology*; D004715:Endometriosis / Q000097:blood / Q000188:drug therapy*; D004967:Estrogens / Q000097:blood*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D007889:Leiomyoma / Q000097:blood / Q000188:drug therapy*; D000077289:Letrozole; D016729:Leuprolide / Q000627:therapeutic use*; D007986:Luteinizing Hormone / Q000097:blood; D009570:Nitriles / Q000494:pharmacology*; D011374:Progesterone / Q000097:blood; D014230:Triazoles / Q000494:pharmacology*
D047072:Aromatase Inhibitors; D004967:Estrogens; D009570:Nitriles; D014230:Triazoles; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone; D000077289:Letrozole; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D016729:Leuprolide