Genetic mapping in human disease.
Genetic mapping provides a powerful approach to identify genes and biological processes underlying any trait influenced by inheritance, including human diseases. We discuss the intellectual foundations of genetic mapping of Mendelian and complex traits in humans, examine lessons emerging from linkage analysis of Mendelian diseases and genome-wide association studies of common diseases, and discuss questions and challenges that lie ahead.
Altshuler
David
D
Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. altshuler@molbio.mgh.harvard.edu
Daly
Mark J
MJ
Lander
Eric S
ES
D002874:Chromosome Mapping; D003001:Cloning, Molecular; D004194:Disease / Q000235:genetics*; D008040:Genetic Linkage; D015894:Genome, Human; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D009154:Mutation; D020161:Physical Chromosome Mapping; D020641:Polymorphism, Single Nucleotide; D019655:Quantitative Trait, Heritable; D012307:Risk Factors; D012641:Selection, Genetic