Iron-catalyzed enyne cross-coupling reaction.
In the presence of 0.5-1 mol % of FeCl(3) with lithium bromide as a crucial additive, alkynyl Grignard reagents, prepared from the corresponding alkynes and methylmagnesium bromide, react with alkenyl bromides or triflates to give the corresponding conjugated enynes in high to excellent yields. The reaction shows wide applicability to various terminal alkynes and alkenyl electrophiles.
Hatakeyama
Takuji
T
International Research Center for Elements Science, Institute for Chemical Research, Kyoto University, Uji, Kyoto, 611-0011, Japan.
Yoshimoto
Yuya
Y
Gabriel
Toma
T
Nakamura
Masaharu
M
D000475:Alkenes / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D001965:Bromides / Q000737:chemistry; D002384:Catalysis; D007202:Indicators and Reagents / Q000737:chemistry; D007501:Iron / Q000737:chemistry*; D020058:Styrene / Q000737:chemistry
D000475:Alkenes; D000480:Alkynes; D001965:Bromides; D007202:Indicators and Reagents; D020058:Styrene; D007501:Iron