Christopher Hughes: an in vitro model for the study of angiogenesis (interview).
Christopher C.W. Hughes describes the utility of his culture system for studying angiogenesis in vitro. He explains the importance of fibroblasts that secrete a critical, yet unidentified, soluble factor that allow endothelial cells to form vessels in culture that branch, form proper lumens, and undergo anastamosis.
Hughes
Christopher C W
CC
Department of Molecular Biology and Biochemistry, University of California, Irvine, USA.
D018929:Cell Culture Techniques / Q000379:methods*; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000166:cytology / Q000502:physiology*; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology*; D006801:Humans; D018919:Neovascularization, Physiologic / Q000502:physiology*