title: Comparison of low-dose human menopausal gonadotropin and micronized 17beta-estradiol supplementation in in vitro maturation cycles with thin endometrial lining.
abstract: OBJECTIVE
  A challenge of in vitro maturation (IVM) treatment in some women is insufficient development of the endometrium prior to embryo transfer.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  McGill Reproductive Center, Montreal, Canada.
  
  
  METHODS
  Women with endometrial thickness <6 mm on days 6-10 ultrasound (US) scan of IVM treatment.
  
  
  METHODS
  In the human menopausal gonadotropin (hMG) group, 150 IU/day of hMG was started and in the estradiol group, 6 to 12 mg/day of micronized 17beta-estradiol was initiated. Additional US scans were performed 2 to 3 days apart, until endometrial thickness reached > or =8 mm or a dominant follicle (>10 mm) was identified.
  
  
  METHODS
  Endometrial lining before oocyte retrival.
  
  
  RESULTS
  In both groups endometrial lining significantly thickened following treatment. However, hMG treatment resulted in a higher number of follicles > or =7 mm compared to estradiol (7.4 +/- 4.8 vs. 3.4 +/- 2.5, respectively) and a significantly higher percentage of mature oocytes that were identified on the day of oocyte retrieval (in vivo matured oocytes) (15.1% vs. 10.5%).
  
  
  CONCLUSIONS
  In IVM designated cycles with a thin endometrium both low-dose hMG and micronized 17beta-estradiol supplementation significantly improve endometrial thickness. However, low-dose hMG results in larger follicles and a greater number of in vivo matured oocytes.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, McGill Reproductive Center, McGill University Health Center, Montreal, Quebec, Canada. Electronic address: shai.elizur@gmail.com.
authors.forename: Shai E
authors.initials: SE
authors.lastname: Elizur
authors.affiliation: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, McGill Reproductive Center, McGill University Health Center, Montreal, Quebec, Canada.
authors.forename: Weon-Young
authors.initials: WY
authors.lastname: Son
authors.affiliation: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, McGill Reproductive Center, McGill University Health Center, Montreal, Quebec, Canada.
authors.forename: Raymond
authors.initials: R
authors.lastname: Yap
authors.affiliation: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, McGill Reproductive Center, McGill University Health Center, Montreal, Quebec, Canada.
authors.forename: Yariv
authors.initials: Y
authors.lastname: Gidoni
authors.affiliation: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, McGill Reproductive Center, McGill University Health Center, Montreal, Quebec, Canada.
authors.forename: Dan
authors.initials: D
authors.lastname: Levin
authors.affiliation: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, McGill Reproductive Center, McGill University Health Center, Montreal, Quebec, Canada.
authors.forename: Ezgi
authors.initials: E
authors.lastname: Demirtas
authors.affiliation: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, McGill Reproductive Center, McGill University Health Center, Montreal, Quebec, Canada.
authors.forename: Seang-Lin
authors.initials: SL
authors.lastname: Tan
mesh_terms: D000328:Adult; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004624:Embryo Transfer / Q000379:methods*; D004717:Endometrium / Q000166:cytology / Q000000981:diagnostic imaging* / Q000187:drug effects*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D005300:Fertility Agents, Female / Q000494:pharmacology*; D005307:Fertilization in Vitro / Q000379:methods; D006801:Humans; D008596:Menotropins / Q000494:pharmacology*; D008597:Menstrual Cycle / Q000187:drug effects*; D009865:Oocytes / Q000166:cytology / Q000187:drug effects; D016471:Ovarian Hyperstimulation Syndrome / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D005300:Fertility Agents, Female; D004958:Estradiol; D008596:Menotropins