Spectrophotometric determination of some phenothiazine derivatives and opipramol with chloramine-T.
This paper describes a spectrophotometric method for the assay of phenothiazines (and also opipramol, which is similar but contains a CC linkage instead of the S atom of the phenothiazines) as the pure drug or in tablets or solutions for injection. The colour is produced by heating a solution of the drug or drug preparation with a solution of chloramine-T. The coloured product can be extracted into chloroform before the colour measurement or the whole process carried out in ethanol solution, the colour of which is then measured.
Issa
A S
AS
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
Beltagy
Y A
YA
Mahrous
M S
MS