title: New algorithms to map asymmetries of 3D surfaces.
abstract: In this paper, we propose a set of new generic automated processing tools to characterise the local asymmetries of anatomical structures (represented by surfaces) at an individual level, and within/between populations. The building bricks of this toolbox are: (1) a new algorithm for robust, accurate, and fast estimation of the symmetry plane of grossly symmetrical surfaces, and (2) a new algorithm for the fast, dense, nonlinear matching of surfaces. This last algorithm is used both to compute dense individual asymmetry maps on surfaces, and to register these maps to a common template for population studies. We show these two algorithms to be mathematically well-grounded, and provide some validation experiments. Then we propose a pipeline for the statistical evaluation of local asymmetries within and between populations. Finally we present some results on real data.
authors.affiliation: INSERM, U746, F-35042 Rennes, France. bcombes@irisa.fr
authors.forename: Benoît
authors.initials: B
authors.lastname: Combès
authors.forename: Sylvain
authors.initials: S
authors.lastname: Prima
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique