title: Association of new arterial stiffness parameter, the cardio-ankle vascular index, with left ventricular diastolic function.
abstract: OBJECTIVE
  Pulse wave velocity has been used as an index of aortic stiffness. Recently, the cardio-ankle vascular index (CAVI), which reflects the stiffness of the aorta independently of blood pressure, has been developed. In this study, we analyzed the relationship between CAVI and left ventricular (LV) diastolic dysfunction.
  
  
  METHODS
  A total of 119 patients were referred for echocardiography to evaluate ventricular function. Patients with reduced systolic function were excluded. Patients were divided on the basis of normal or reduced LV diastolic function determined by echocardiography. CAVI was measured using an automatic waveform analyzer.
  
  
  RESULTS
  CAVI was significantly higher in patients with reduced LV diastolic function than those with normal LV diastolic function (9.0+/-1.1 and 8.5+/-1.1, p=0.009). Multiple linear regression analysis revealed that CAVI was independently associated with the ratio of peak early diastolic velocity to peak atrial diastolic velocity and left atrial diameter. When patients were classified on the basis of CAVI quartiles, multiple logistic regression analysis demonstrated that the highest quartile of CAVI showed an increased odds ratio for the presence of LV diastolic dysfunction.
  
  
  CONCLUSIONS
  The present study revealed that an increased CAVI was independently associated with LV diastolic dysfunction in patients with preserved systolic function.
authors.affiliation: Department of Medicine and Medical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Sakane
authors.forename: Toru
authors.initials: T
authors.lastname: Miyoshi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Doi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hirohata
authors.forename: Youko
authors.initials: Y
authors.lastname: Kaji
authors.forename: Shigeshi
authors.initials: S
authors.lastname: Kamikawa
authors.forename: Hiroko
authors.initials: H
authors.lastname: Ogawa
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Hatanaka
authors.forename: Tomoki
authors.initials: T
authors.lastname: Kitawaki
authors.forename: Shozo
authors.initials: S
authors.lastname: Kusachi
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Yamamoto
mesh_terms: D000368:Aged; D055109:Ankle Brachial Index; D001011:Aorta / Q000503:physiopathology*; D003971:Diastole; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D014655:Vascular Resistance; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis*