title: The PAZAR database of gene regulatory information coupled to the ORCA toolkit for the study of regulatory sequences.
abstract: The PAZAR database unites independently created and maintained data collections of transcription factor and regulatory sequence annotation. The flexible PAZAR schema permits the representation of diverse information derived from experiments ranging from biochemical protein-DNA binding to cellular reporter gene assays. Data collections can be made available to the public, or restricted to specific system users. The data 'boutiques' within the shopping-mall-inspired system facilitate the analysis of genomics data and the creation of predictive models of gene regulation. Since its initial release, PAZAR has grown in terms of data, features and through the addition of an associated package of software tools called the ORCA toolkit (ORCAtk). ORCAtk allows users to rapidly develop analyses based on the information stored in the PAZAR system. PAZAR is available at http://www.pazar.info. ORCAtk can be accessed through convenient buttons located in the PAZAR pages or via our website at http://www.cisreg.ca/ORCAtk.
authors.affiliation: Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Elodie
authors.initials: E
authors.lastname: Portales-Casamar
authors.forename: David
authors.initials: D
authors.lastname: Arenillas
authors.forename: Jonathan
authors.initials: J
authors.lastname: Lim
authors.forename: Magdalena I
authors.initials: MI
authors.lastname: Swanson
authors.forename: Steven
authors.initials: S
authors.lastname: Jiang
authors.forename: Anthony
authors.initials: A
authors.lastname: McCallum
authors.forename: Stefan
authors.initials: S
authors.lastname: Kirov
authors.forename: Wyeth W
authors.initials: WW
authors.lastname: Wasserman
mesh_terms: D001483:Base Sequence; D001665:Binding Sites; D017124:Conserved Sequence; D030541:Databases, Genetic; D005786:Gene Expression Regulation; D050436:Regulatory Elements, Transcriptional; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D012984:Software; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D014157:Transcription Factors