title: Possible pathogenic link between migraine and urotensin-II.
abstract: Our aim was to determine the levels of human urotensin-II (hU-II) in the plasma of migraine patients and controls, to ascertain if there were a difference in the pathogenesis of migraine. A total of 27 patients who suffer from migraines and 27 controls were included in the study. Venous blood samples were drawn twice both from migraine patients and controls to measure hU-II plasma levels. The average levels of hU-II during migraine episode, between episodes, and controls were found to be 0.483, 0.493, and 0.737 pg/mL, respectively. The levels of hU-II in the controls were higher significantly. When comparisons were made according to sex, age groups, and types and durations of migraine, there was no significant difference in the levels of hU-II in the patients. The low levels of hU-II in the plasma of migraine patients compared with controls may be an indicator of its role in the pathogenesis.
authors.affiliation: Department of Pediatrics, Inonu University Medical School, Malatya, Turkey.
authors.forename: Ugur
authors.initials: U
authors.lastname: Bicak
authors.forename: Hamza
authors.initials: H
authors.lastname: Karabiber
authors.forename: Halil I
authors.initials: HI
authors.lastname: Ozerol
authors.forename: Mehmet
authors.initials: M
authors.lastname: Aslan
authors.forename: Atilla
authors.initials: A
authors.lastname: Ilhan
authors.forename: Cengiz
authors.initials: C
authors.lastname: Yakinci
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood*; D014579:Urotensins / Q000097:blood*; D055815:Young Adult
chemical_list: D014579:Urotensins; C029677:urotensin II