title: Allium vegetables intake and endometrial cancer risk.
abstract: OBJECTIVE
  The potential role of allium vegetables on endometrial cancer risk has been scarcely investigated and the results of previous Chinese studies are not easily applicable to Western populations. Therefore, we evaluated the relationship between onion and garlic intake and endometrial cancer, using data from an Italian case-control study.
  
  
  METHODS
  We analysed data from a multi-centre case-control study of 454 endometrial cancer cases and 908 controls, admitted to the same hospitals for a wide spectrum of acute, non-neoplastic conditions. Information was collected by trained interviewers using a validated and reproducible FFQ. Multivariate odds ratios and 95% confidence intervals were obtained after allowance for recognized confounding factors.
  
  
  RESULTS
  Compared with non-users, the OR of endometrial cancer for successive categories of onion intake were 0.94 (95% CI 0.72, 1.21) for <2 portions/week and 0.40 (95% CI 0.22, 0.72) for > or =2 portions/week, with a significant inverse trend in risk (P = 0.01). The OR for an increment of one portion (i.e. 80 g) of onions per week was 0.81 (95% CI 0.70, 0.95). For garlic, the OR for successive categories of intake were 0.89 (95% CI 0.68, 1.15) for intermediate use and 0.62 (95% CI 0.42, 0.92) for high use, with a significant inverse trend in risk (P = 0.02).
  
  
  CONCLUSIONS
  Our study found a moderate protective role of allium vegetables on the risk of endometrial cancer.
authors.affiliation: Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, I-20156 Milan, Italy. galeone@marionegri.it
authors.forename: Carlotta
authors.initials: C
authors.lastname: Galeone
authors.forename: Claudio
authors.initials: C
authors.lastname: Pelucchi
authors.forename: Luigino
authors.initials: L
authors.lastname: Dal Maso
authors.forename: Eva
authors.initials: E
authors.lastname: Negri
authors.forename: Maurizio
authors.initials: M
authors.lastname: Montella
authors.forename: Antonella
authors.initials: A
authors.lastname: Zucchetto
authors.forename: Renato
authors.initials: R
authors.lastname: Talamini
authors.forename: Carlo
authors.initials: C
authors.lastname: La Vecchia
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000490:Allium; D016022:Case-Control Studies; D016001:Confidence Intervals; D016889:Endometrial Neoplasms / Q000453:epidemiology / Q000517:prevention & control*; D005260:Female; D005737:Garlic; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008875:Middle Aged; D016017:Odds Ratio; D019697:Onions; D012307:Risk Factors; D014675:Vegetables; D055815:Young Adult