A new ferulic acid ester and other constituents from Dracocephalum peregrinum.
A new ferulic acid ester, 1'-methyl-2'-hydroxyethyl ferulate (1), together with methylcaffeate (2), 4-hydroxy cinnamic acid (3), ferulic acid (4), caffeic acid (5), diosmetin (6), luteolin (7), 5,3',4'-trihydroxy-3,7-dimethoxyflavone (8), eriodictyol (9), kaempferol (10), quercetin (11), acacetin-7-O-glcopyranoside (12), 4-(beta-glucopyranosyloxy) benzoic acid (13), luteolin-7-O-(6''-feruloyl) glucopyranoside (14), luteolin-7-O-glucopyranoside (15), kaempferide-3-O-rhamnopyranoside (16), quercitrin (17), kaempferol-3-O-glucopyranoside (18), prunasin (19), quercetin-7-O-glucopyranoside (20), quercetin-3-O-glucopyranoside (21), plantaginin (22), linarin (23), luteolin-7-O-rutinoside (24), and chlorogenic acid (25) were isolated from the aerial parts of Dacocephalum peregrinum. The structure of 1 was elucidated on the basis of spectroscopic and HR-ESI-MS analyses. In addition, compound 1 exhibited mild inhibitory effect on NO production in LPS-stimulated RAW264.7 cells.
Dai
Li-Min
LM
School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410004, PR China.
Zhao
Chun-Chao
CC
Jin
Hui-zi
HZ
Tang
Jian
J
Shen
Yun-Heng
YH
Li
Hui-Liang
HL
Peng
Cai-Yun
CY
Zhang
Wei-Dong
WD
D000818:Animals; D002855:Chromatography, Thin Layer; D003373:Coumaric Acids / Q000737:chemistry* / Q000302:isolation & purification; D004121:Dimethyl Sulfoxide; D019686:Lamiaceae / Q000737:chemistry*; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis; D010936:Plant Extracts / Q000737:chemistry; D012997:Solvents; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D013778:Tetrazolium Salts; D013844:Thiazoles
C533539:1'-methyl-2'-hydroxyethyl ferulate; D003373:Coumaric Acids; D010936:Plant Extracts; D012997:Solvents; D013778:Tetrazolium Salts; D013844:Thiazoles; D009569:Nitric Oxide; C004999:ferulic acid; C022616:thiazolyl blue; D004121:Dimethyl Sulfoxide