Liquid chromatographic determination of the known low level impurities in lovastatin bulk drug: An application of high-low chromatography.
High-low chromatography in combination with gradient elution and multiple wavelength detection is a rapid and sensitive technique that can be used to assay low level impurities in lovastatin. The method is reproducible and can be applied to samples containing as little as 0.1% of any known impurity.
Houck
A
A
Merck Sharp & Dohme Research Laboratories, P.O. Box 2000, Rahway, NJ 07065, USA.
Thomas
S
S
Ellison
D K
DK