title: Direct catalytic asymmetric synthesis of cyclic aminals from aldehydes.
abstract: A highly enantioselective Brønsted acid catalyzed direct synthesis of cyclic aminals from aldehydes has been developed. The methodology has been applied to the first asymmetric synthesis of several antihypertensive aminal drugs including (R)-Thiabutazide.
authors.affiliation: Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1,D-45470, Mülheim an der Ruhr, Germany.
authors.forename: Xu
authors.initials: X
authors.lastname: Cheng
authors.forename: Sreekumar
authors.initials: S
authors.lastname: Vellalath
authors.forename: Richard
authors.initials: R
authors.lastname: Goddard
authors.forename: Benjamin
authors.initials: B
authors.lastname: List
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D002851:Chromatography, High Pressure Liquid; D003500:Cyclization; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism; D062367:ortho-Aminobenzoates / Q000737:chemistry
chemical_list: D000447:Aldehydes; D000588:Amines; D062367:ortho-Aminobenzoates; C000219:anthranilamide