Platelet-activating factor antagonistic activity and(13)C NMR assignment of pregomisin and chamigrenal fromSchisandra chinensis.
In the course of searching for PAF receptor antagonists, pregomisin (1) and chamigrenal (2) were isolated from the fruits ofSchizandra chinensis Baill by the bioactivity-guided isolation. Both compounds showed PAF antagonistic activity and the IC(50) values were 4.8x10(-5) M and 1.2x10(-4) M, respectively. In addition, the(13)C NMR assignments of1 and2 using DEPT, HMQC, COLOC and HMBC were reported for the first time.
Lee
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Natural Product Biosynthesis Research Unit, Korea Research Institute of Bioscience & Biotechnology, Yusong, P.O. Box 115, 305-600, Taejon, Korea.
Jung
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Oh
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Kim
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Kim
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Lee
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Lee
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Lee
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Kim
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Cheong
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