Preventive effects of total flavonoids of Litsea coreana leve on hepatic steatosis in rats fed with high fat diet.
OBJECTIVE
To evaluate the protective effects of total flavonoids of Litsea Coreana leve (TFLC) on rat high fat diet-induced hepatic steatosis model.


METHODS
Rats were given either a high fat diet alone or the same diet plus TFLC for 4 weeks.


RESULTS
TFLC improved liver histology with reduced serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), as well as decreased the over accumulation lipids in serum and liver. TFLC increased serum levels of leptin and insulin, while decreased serum TNFalpha level in high fat diet fed rat. Furthermore, TFLC was found increased the expression of peroxisome proliferator-activated receptor alpha (PPARalpha) in high fat diet fed rat liver. These benefits were associated with increased superoxide dismutase (SOD) and decreased malondialdehyde (MDA) in high fat diet fed rat liver.


CONCLUSIONS
TFLC exerts protective effects against hepatic steatosis in rats fed with high fat diet possibly through its antioxidant actions, improving the adipocytokines release and increasing the expression of PPARalpha.
Wang
Jian-Qing
JQ
School of Pharmacy, Anhui Medical University, Hefei, Anhui, China.
Li
Jun
J
Zou
Yu-Hong
YH
Cheng
Wen-Ming
WM
Lu
Chao
C
Zhang
Lei
L
Ge
Jin-Fang
JF
Huang
Cheng
C
Jin
Yong
Y
Lv
Xiong-Wen
XW
Hu
Cheng-Mu
CM
Liu
Li-Ping
LP
D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D001219:Aspartate Aminotransferases / Q000378:metabolism; D004041:Dietary Fats / Q000008:administration & dosage; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use; D005234:Fatty Liver / Q000201:enzymology / Q000209:etiology / Q000517:prevention & control*; D005419:Flavonoids / Q000494:pharmacology / Q000627:therapeutic use*; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D032862:Litsea / Q000737:chemistry*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008517:Phytotherapy; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D000975:Antioxidants; D004041:Dietary Fats; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D007328:Insulin; D020738:Leptin; D014409:Tumor Necrosis Factor-alpha; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase