title: Reactome knowledgebase of human biological pathways and processes.
abstract: Reactome (http://www.reactome.org) is an expert-authored, peer-reviewed knowledgebase of human reactions and pathways that functions as a data mining resource and electronic textbook. Its current release includes 2975 human proteins, 2907 reactions and 4455 literature citations. A new entity-level pathway viewer and improved search and data mining tools facilitate searching and visualizing pathway data and the analysis of user-supplied high-throughput data sets. Reactome has increased its utility to the model organism communities with improved orthology prediction methods allowing pathway inference for 22 species and through collaborations to create manually curated Reactome pathway datasets for species including Arabidopsis, Oryza sativa (rice), Drosophila and Gallus gallus (chicken). Reactome's data content and software can all be freely used and redistributed under open source terms.
authors.affiliation: Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
authors.forename: Lisa
authors.initials: L
authors.lastname: Matthews
authors.forename: Gopal
authors.initials: G
authors.lastname: Gopinath
authors.forename: Marc
authors.initials: M
authors.lastname: Gillespie
authors.forename: Michael
authors.initials: M
authors.lastname: Caudy
authors.forename: David
authors.initials: D
authors.lastname: Croft
authors.forename: Bernard
authors.initials: B
authors.lastname: de Bono
authors.forename: Phani
authors.initials: P
authors.lastname: Garapati
authors.forename: Jill
authors.initials: J
authors.lastname: Hemish
authors.forename: Henning
authors.initials: H
authors.lastname: Hermjakob
authors.forename: Bijay
authors.initials: B
authors.lastname: Jassal
authors.forename: Alex
authors.initials: A
authors.lastname: Kanapin
authors.forename: Suzanna
authors.initials: S
authors.lastname: Lewis
authors.forename: Shahana
authors.initials: S
authors.lastname: Mahajan
authors.forename: Bruce
authors.initials: B
authors.lastname: May
authors.forename: Esther
authors.initials: E
authors.lastname: Schmidt
authors.forename: Imre
authors.initials: I
authors.lastname: Vastrik
authors.forename: Guanming
authors.initials: G
authors.lastname: Wu
authors.forename: Ewan
authors.initials: E
authors.lastname: Birney
authors.forename: Lincoln
authors.initials: L
authors.lastname: Stein
authors.forename: Peter
authors.initials: P
authors.lastname: D'Eustachio
mesh_terms: D000818:Animals; D030562:Databases, Protein; D006801:Humans; D053858:Metabolic Networks and Pathways; D023421:Models, Animal; D010829:Physiological Phenomena; D011506:Proteins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction; D012984:Software; D018511:Systems Integration
chemical_list: D011506:Proteins