Amperometric determination of acetylsalicylic acid in drugs by batch injection analysis at a copper electrode in alkaline solutions.
This paper describes the determination of acetylsalicylic acid (ASA) as salicylate (SA) in pharmaceutical formulations by using amperometric detection with copper electrodes in 0.10 mol l(-1) NaOH solution. Batch injection analysis (BIA) was explored for this application. The system exhibited sharp current response peaks, rapid washout and excellent repeatability. A large linear dynamic range from 1 to 1000 mumol l(-1) was obtained by using an injected volume of 100 mul, with a detection limit of 0.48 mumol l(-1). R.S.D. of 0.37% for 30 repetitive (1x10(-4) mol l(-1)) injections and sampling frequency of 60 h(-1) were achieved. The results obtained using this system for ASA determination in seven different drug samples compared well with those found by spectrophotometry (Trinder test).
do Socorro Maia Quintino
Maria
M
Instituto de Quimica, Universidade de São Paulo, Avenida Prof. Lineu Prestes, 748 CEP 05599-970, São Paulo, SP, Brazil.
Corbo
Dennys
D
Bertotti
Mauro
M
Angnes
Lúcio
L