title: Release of growth factors after arthroscopic acromioplasty.
abstract: It has recently been postulated that a variety of growth factors may be released from cancellous bone after an acromioplasty. The aim of this study was to demonstrate the presence of growth factors in the subacromial space after acromioplasty. Between October 2006 and March 2007, 23 patients underwent arthroscopic acromioplasty. A sample of at least 3 ml of fluid from the shoulder was obtained 15 min after the end of the procedure. At the same time another sample of 3 ml of the patient's venous blood was obtained as a control. The concentrations of growth factors in the fluids collected were determined using enzyme-linked immunosorbent assay (ELISA). The growth factors assayed were platelet-derived growth factor-AB (PDGF-AB), basic fibroblast growth factor basic (bFGF) and transforming growth factor beta 1 (TGF-beta1). The concentrations of TGF-beta1 (p = 0.0001), PDGF-AB (p = 0.02), and bFGF (p < 0.0001) were significantly higher in the fluid from the subacromial space than in the blood sample. There are high concentrations of several growth factors in the subacromial space after acromioplasty.
authors.affiliation: Dipartimento di Scienze Medico-Chirurgiche, Università degli Studi di Milano, IRCCS Policlinico San Donato, Via Morandi 30, San Donato Milanese 20097, Milan, Italy. pietro.randelli@unimi.it
authors.forename: Pietro
authors.initials: P
authors.lastname: Randelli
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Margheritini
authors.forename: Paolo
authors.initials: P
authors.lastname: Cabitza
authors.forename: Giada
authors.initials: G
authors.lastname: Dogliotti
authors.forename: Massimiliano M
authors.initials: MM
authors.lastname: Corsi
mesh_terms: D000173:Acromioclavicular Joint / Q000293:injuries / Q000502:physiology / Q000601:surgery*; D001178:Arthroplasty; D001182:Arthroscopy / Q000379:methods; D016222:Fibroblast Growth Factor 2 / Q000097:blood; D006801:Humans; D008875:Middle Aged; D010982:Platelet-Derived Growth Factor / Q000032:analysis; D017006:Rotator Cuff / Q000601:surgery*; D000070636:Rotator Cuff Injuries; D019534:Shoulder Impingement Syndrome / Q000601:surgery; D013582:Synovial Fluid / Q000737:chemistry* / Q000378:metabolism; D053773:Transforming Growth Factor beta1 / Q000097:blood
chemical_list: D010982:Platelet-Derived Growth Factor; D053773:Transforming Growth Factor beta1; C095477:platelet-derived growth factor AB; D016222:Fibroblast Growth Factor 2