title: Rapid improvement in pain and functional level in a patient with metastatic renal cell carcinoma: a case report and review of the literature.
abstract: Renal cell carcinoma (RCC) represents approximately 3% of all adult cancers and is more common in males. Systemic treatment for RCC has improved following the introduction of sunitinib. Bone metastases are present in up to 50% of RCC patients. We report a case of rapid improvement in metastatic bone lesions, recorded by nuclear bone scan, in a male patient receiving localized palliative radiotherapy in addition to systemic sunitinib and zoledronic acid. Concurrently, quality of life and performance status improved dramatically. Although we are unsure of the exact mechanism for such rapid improvement in metastatic bone lesions, the swiftness this improvement deserves reporting.
authors.affiliation: Rapid Response Radiotherapy Program, Radiation Oncology, Odette Cancer Centre, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Amanda E
authors.initials: AE
authors.lastname: Hird
authors.forename: Edward
authors.initials: E
authors.lastname: Chow
authors.forename: Lisa
authors.initials: L
authors.lastname: Ehrlich
authors.forename: Linda
authors.initials: L
authors.lastname: Probyn
authors.forename: Emily
authors.initials: E
authors.lastname: Sinclair
authors.forename: Darwin
authors.initials: D
authors.lastname: Yip
authors.forename: Yoo-Joung
authors.initials: YJ
authors.lastname: Ko
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage; D050071:Bone Density Conservation Agents / Q000008:administration & dosage; D001859:Bone Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary; D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D004164:Diphosphonates / Q000008:administration & dosage; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage; D007211:Indoles / Q000008:administration & dosage; D007680:Kidney Neoplasms / Q000473:pathology / Q000628:therapy*; D008297:Male; D009392:Nephrectomy; D059408:Pain Management; D010166:Palliative Care / Q000379:methods*; D011758:Pyrroles / Q000008:administration & dosage; D011788:Quality of Life; D000077210:Sunitinib; D000077211:Zoledronic Acid
chemical_list: D000970:Antineoplastic Agents; D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D007211:Indoles; D011758:Pyrroles; D000077211:Zoledronic Acid; D000077210:Sunitinib