Voltammetric studies of the effect of Cisplatin-liposome on Hela cells.
In this paper, the voltammetric method was used for the first time to study the effect of Cisplatin-liposome on Hela cells. The results showed the voltammetric behavior of Hela cells was irreversible and the peak current had linear relationship with the cell number. With both Cisplatin-liposome concentration and treating time increasing, the peak current decreased. The peak current decreasing was in accordance with the nuclear damage and loss of mitochondrial membrane potential revealed by two-photon laser scanning microscopy and confocal laser scanning microscopy. This voltammetric method may provide a simple way to study the electron-transfer mechanism in drug-treating cells.
Ci
Y X
YX
Department of Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Zhai
Q
Q
Wang
S
S
Chang
W B
WB
Zhang
C Y
CY
Ma
H
H
Chen
D Y
DY
Zhao
M Z
MZ
Hu
S W
SW