title: Ductal carcinoma in situ: correlation between FDG-PET/CT and histopathology.
abstract: OBJECTIVE
  The aim of this study was to determine if any correlation exists between tumor cell density and fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET)/CT) for pure or predominant ductal carcinoma in situ (DCIS).
  
  
  METHODS
  Subjects in this retrospective review comprised 11 patients who underwent FDG-PET/CT for DCIS. Pathological tumor cell density and FDG-PET/CT images were compared. A tumor background count density ratio of >1.5 was defined as the detectable range for DCIS.
  
  
  RESULTS
  Pathological density of disease was high in eight patients, intermediate in one, and low in two. In all eight patients with a detectable intraductal component on PET/CT, the density of disease was classified as high. In three patients undetected by PET/CT, the density of disease was classified as intermediate or low. On statistical analysis, the correlation between the density of disease and tumor background count density ratio (TBCDR) on PET/CT was significant (<0.05), whereas the nuclear grade and Van Nuys grade were not significant. In the eight patients detected by PET/CT, the discrepancy between histopathological mapping and FDG-PET/CT mapping was >20 mm in four patients and represented underestimation in four patients who showed low density of disease in the peripheral area.
  
  
  CONCLUSIONS
  Tumor cell density of intraductal carcinoma appears strongly correlated to detection by FDG-PET/CT.
authors.affiliation: Department of Radiology, Kameda Medical Center, 929 Higashi-cho, Kamogawa, 296-8602, Japan. asakonemurinomori@yahoo.co.jp
authors.forename: Asako
authors.initials: A
authors.lastname: Azuma
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Tozaki
authors.forename: Kensuke
authors.initials: K
authors.lastname: Ito
authors.forename: Eisuke
authors.initials: E
authors.lastname: Fukuma
authors.forename: Tomoko
authors.initials: T
authors.lastname: Tanaka
authors.forename: Toshihiro
authors.initials: T
authors.lastname: O'uchi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008875:Middle Aged; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18