A new spectrophotometric method for the determination of promethazine-HCl from pure and pharmaceutical preparations.
Promethazine-HCl reacts with potassium persulphate to give a pinkish red color complex exhibiting maximum absorbance at 515nm. The reaction is selective for promethazine-HCl, with 1mug/mL as visual limit of identification and provides a basis for a new spectrophotometric determination method. The color forming reaction obeys Beer's Law from 0.001 to 0.125mg/mL of promethazine-HCl. The relative standard deviation does not exceed 0.005mg/mL. The method is successfully applied to pure and pharmaceutical formulations of promethazine-HCl. The quantitative assessment of tolerable amounts of possible interferants was also studied. The results are reproducible within +/-1% and in good agreement with those obtained by the standard procedure.
Saif
Muhammad Jawwad
MJ
Institute of Chemistry, University of the Punjab, Quid-e-Azam Campus, Lahore-54590, Pakistan.
Anwar
Jamil
J