Spectrophotometric determination of tranexamic acid with chloranil.
Tranexamic acid is reacted with aqueous alcoholic chloranil, buffered at pH 9, to give a complex with maximum absorption at 346 nm and with an apparent molar absorptivity of 15.7 x 10(3) l.mole(-1).cm(-1). A(max) is linearly related to concentration over the range 2-10 mug ml . When applied to tablets labelled as containing 500 mg each, the mean found was 496 +/- 4 mg. The results were comparable with those of the traditional formol titration method for amino-acids.
Wahbi
A A
AA
College of Pharmacy, King Saud University, Pharmaceutical Chemistry Department, Riyadh, Saudi Arabia.
Lotfi
E A
EA
Aboul-Enein
H Y
HY