New cell or new cycle?
In mammals, trophoblast giant (TG) cell differentiation is characterized by a physiological endoreduplication, resulting in genome size augmentation. A recent study by Ullah and colleagues (pp. 3024-3036), published in this issue of Genes & Development, now elucidates the role of the cyclin-dependent kinase inhibitors (CKIs), p21 and p57, in mammalian endocycle regulation.
Ganier
Olivier
O
Institute of Human Genetics, CNRS, Montpellier, France.
Mechali
Marcel
M
D000818:Animals; D016203:CDC2 Protein Kinase / Q000037:antagonists & inhibitors / Q000502:physiology*; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology; D050761:Cyclin-Dependent Kinase Inhibitor p57 / Q000502:physiology*; D015726:Giant Cells / Q000166:cytology* / Q000502:physiology; D014327:Trophoblasts / Q000166:cytology* / Q000502:physiology; D054462:p21-Activated Kinases / Q000502:physiology
D018797:Cell Cycle Proteins; D050761:Cyclin-Dependent Kinase Inhibitor p57; D054462:p21-Activated Kinases; D016203:CDC2 Protein Kinase