title: A novel biocompatible adhesive incorporating plant-derived monomers.
abstract: We describe a new class of biomaterials with potential for a variety of applications in tissue engineering, wound healing, and transdermal drug delivery. These materials are based on oleic methyl ester (OME), which is derived from various plant oils including soybean oil. The OME was acrylated (AOME) and subsequently copolymerized with methyl methacrylate (MMA) and ethylene glycol dimethacrylate (EGDMA) to form pressure sensitive adhesives (PSAs). We assessed the cytocompatibility of each PSA product using Alamar Blue and Live/Dead assays. It was found that after 2 h, human fibroblast cells attached on all four of the PSA polymers tested. After 24 h, cell spreading was seen on all materials with the exception of the polymerized AOME product (PAOME). Cells attached to the copolymer PSA products continued to proliferate for up to 2 weeks, as shown by fluorescent confocal microscopy imaging. Finally, a mechanical analysis of each of the copolymers is presented demonstrating that they have a range of mechanical properties and cell adhesiveness depending on the formulation, making them attractive candidates for use as bioactive adhesives.
authors.affiliation: Departments of Mechanical and Biomedical Engineering, Boston University, 44 Cummington St., Boston, MA 02215, USA. catherin@bu.edu
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Klapperich
authors.forename: Cassandra L
authors.initials: CL
authors.lastname: Noack
authors.forename: Jessica D
authors.initials: JD
authors.lastname: Kaufman
authors.forename: Lin
authors.initials: L
authors.lastname: Zhu
authors.forename: Laetitia
authors.initials: L
authors.lastname: Bonnaillie
authors.forename: Richard P
authors.initials: RP
authors.lastname: Wool
mesh_terms: D000269:Adhesives / Q000138:chemical synthesis / Q000737:chemistry*; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry*; D002448:Cell Adhesion; D002470:Cell Survival; D002478:Cells, Cultured; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D008689:Methacrylates / Q000138:chemical synthesis / Q000737:chemistry; D008768:Methylmethacrylates / Q000138:chemical synthesis / Q000737:chemistry; D009829:Oleic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D010944:Plants / Q000737:chemistry; D012867:Skin / Q000166:cytology
chemical_list: D000269:Adhesives; D001672:Biocompatible Materials; D008689:Methacrylates; D008768:Methylmethacrylates; D009829:Oleic Acids; C005576:methyl oleate; C004919:ethylene dimethacrylate