Novel endothall-containing platinum(IV) complexes: synthesis, characterization, and cytotoxic activity.
Two platinum(IV) complexes (OC-6-33)-dichlorido(ethane-1,2-diamine)dihydroxidoplatinum(IV) and (OC-6-33)-diammine(dichlorido)dihydroxidoplatinum(IV) were carboxylated using demethylcantharidin as carboxylation agent. The complexes were characterized by elemental analysis, mass spectrometry, multinuclear (1H, 13C, 15N, and 195Pt) NMR spectroscopy, and, in case of (OC-6-33)-diamminebis(3-carboxy-7exo-oxabicyclo[2.2.1]heptane-2-carboxylato)dichloridoplatinum(IV) via X-ray diffraction. Cytotoxicity of the complexes was studied in seven human cancer cell lines representing five tumor entities, i.e., ovarian carcinoma (CH1, SK-OV-3), cervical carcinoma (HeLa), colon carcinoma (SW480, HCT-116), osteosarcoma (U-2 OS), and hepatocellular carcinoma (Hep G2) by means of the MTT (=3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium hydrobromide) assay.
Reithofer
Michael R
MR
University of Vienna, Institute of Inorganic Chemistry, Währinger Strasse 42, A-1090 Vienna, (phone: +43-1-427752603 (M. G.), +43-1-427752602 (B. K. K.); fax: +43-1-427752680).
Valiahdi
Seied M
SM
University of Vienna, Institute of Inorganic Chemistry, Währinger Strasse 42, A-1090 Vienna, (phone: +43-1-427752603 (M. G.), +43-1-427752602 (B. K. K.); fax: +43-1-427752680).
Galanski
Markus
M
University of Vienna, Institute of Inorganic Chemistry, Währinger Strasse 42, A-1090 Vienna, (phone: +43-1-427752603 (M. G.), +43-1-427752602 (B. K. K.); fax: +43-1-427752680).
Jakupec
Michael A
MA
University of Vienna, Institute of Inorganic Chemistry, Währinger Strasse 42, A-1090 Vienna, (phone: +43-1-427752603 (M. G.), +43-1-427752602 (B. K. K.); fax: +43-1-427752680).
Arion
Vladimir B
VB
University of Vienna, Institute of Inorganic Chemistry, Währinger Strasse 42, A-1090 Vienna, (phone: +43-1-427752603 (M. G.), +43-1-427752602 (B. K. K.); fax: +43-1-427752680).
Keppler
Bernhard K
BK
University of Vienna, Institute of Inorganic Chemistry, Währinger Strasse 42, A-1090 Vienna, (phone: +43-1-427752603 (M. G.), +43-1-427752602 (B. K. K.); fax: +43-1-427752680).
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002193:Cantharidin / Q000031:analogs & derivatives / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D003998:Dicarboxylic Acids / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D010984:Platinum / Q000737:chemistry*
C534054:(3-carboxyoxabicyclo(2.2.1)heptane-2-carboxylato)dichlorido(ethane-1,2-diamine)platinum(IV); D000970:Antineoplastic Agents; D003998:Dicarboxylic Acids; D009944:Organoplatinum Compounds; C464435:demethylcantharidin; C534055:diamminebis(3-carboxyoxabicyclo(2.2.1)heptane-2-carboxylato)dichloridoplatinum(IV); C100030:endothall; D010984:Platinum; D002193:Cantharidin