title: Hyperkeratosis lenticularis perstans (Flegel's disease) - successful treatment with topical corticosteroids.
abstract: Flegel's disease, also known as hyperkeratosis lenticularis perstans, is a rare skin disease characterized by small, red-brown, hyperkeratotic, papules that are usually located on the lower extremities. The diagnosis is based on the clinical appearance in association with the typical histologic features of orthohyperkeratosis and a subepidermal band-like infiltrate. Treatment is difficult and rarely fully effective. We report on a woman with Flegel's disease who responded to a topical corticosteroid therapy with betamethasone dipropionate.
authors.affiliation: Department of Dermatology, and Maastricht University Center for Molecular Dermatology, University Medical Center Maastricht, The Netherlands. hmv@sder.azm.nl
authors.forename: Heleen
authors.initials: H
authors.lastname: Sterneberg-Vos
authors.forename: Arienne M W
authors.initials: AM
authors.lastname: van Marion
authors.forename: Jorge
authors.initials: J
authors.lastname: Frank
authors.forename: Pamela
authors.initials: P
authors.lastname: Poblete-Gutierrez
mesh_terms: D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001623:Betamethasone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D001706:Biopsy; D005260:Female; D006801:Humans; D007642:Keratosis / Q000188:drug therapy* / Q000473:pathology; D007868:Leg Dermatoses / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged
chemical_list: D000893:Anti-Inflammatory Agents; C011175:betamethasone-17,21-dipropionate; D001623:Betamethasone