title: Influence of interleukin 1alpha (IL-1alpha), IL-4, and IL-6 polymorphisms on genetic susceptibility to chronic osteomyelitis.
abstract: The association between cytokine gene polymorphisms and chronic osteomyelitis was investigated in order to determine whether genetic variability in cytokine genes predisposes to osteomyelitis susceptibility. Significant genotypic and allelic associations were observed between interleukin 1alpha (IL-1alpha) -889-C/T, IL-4 -1098-G/T and -590-C/T, and IL-6 -174-G/C polymorphisms and osteomyelitis in the Greek population, pointing towards their potential involvement in osteomyelitis pathogenesis.
authors.affiliation: University of Thessalia, Medical School, Department of Biology, Mezourlo 41 222 Larissa, Greece. atsezou@med.uth.gr
authors.forename: Aspasia
authors.initials: A
authors.lastname: Tsezou
authors.forename: Lazaros
authors.initials: L
authors.lastname: Poultsides
authors.forename: Fotini
authors.initials: F
authors.lastname: Kostopoulou
authors.forename: Elias
authors.initials: E
authors.lastname: Zintzaras
authors.forename: Maria
authors.initials: M
authors.lastname: Satra
authors.forename: Sofia
authors.initials: S
authors.lastname: Kitsiou-Tzeli
authors.forename: Konstantinos N
authors.initials: KN
authors.lastname: Malizos
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002908:Chronic Disease; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006115:Greece; D006801:Humans; D053582:Interleukin-1alpha / Q000235:genetics*; D015847:Interleukin-4 / Q000235:genetics*; D015850:Interleukin-6 / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D053582:Interleukin-1alpha; D015850:Interleukin-6; D015847:Interleukin-4