title: Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
abstract: We carried out a meta-analysis of data from three genome-wide association (GWA) studies of type 1 diabetes (T1D), testing 305,090 SNPs in 3,561 T1D cases and 4,646 controls of European ancestry. We obtained further support for 4q27 (IL2-IL21, P = 1.9 x 10(-8)) and, after genotyping an additional 6,225 cases, 6,946 controls and 2,828 families, convincing evidence for four previously unknown and distinct risk loci in chromosome regions 6q15 (BACH2, P = 4.7 x 10(-12)), 10p15 (PRKCQ, P = 3.7 x 10(-9)), 15q24 (CTSH, P = 3.2 x 10(-15)) and 22q13 (C1QTNF6, P = 2.0 x 10(-8)).
authors.affiliation: Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. jason.cooper@cimr.cam.ac.uk
authors.forename: Jason D
authors.initials: JD
authors.lastname: Cooper
authors.forename: Deborah J
authors.initials: DJ
authors.lastname: Smyth
authors.forename: Adam M
authors.initials: AM
authors.lastname: Smiles
authors.forename: Vincent
authors.initials: V
authors.lastname: Plagnol
authors.forename: Neil M
authors.initials: NM
authors.lastname: Walker
authors.forename: James E
authors.initials: JE
authors.lastname: Allen
authors.forename: Kate
authors.initials: K
authors.lastname: Downes
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Barrett
authors.forename: Barry C
authors.initials: BC
authors.lastname: Healy
authors.forename: Josyf C
authors.initials: JC
authors.lastname: Mychaleckyj
authors.forename: James H
authors.initials: JH
authors.lastname: Warram
authors.forename: John A
authors.initials: JA
authors.lastname: Todd
mesh_terms: D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D020641:Polymorphism, Single Nucleotide