Neurochemical dementia diagnostics: assays in CSF and blood.
In this review, current neurochemical dementia diagnostics (NDD) procedures are presented with a focus on biomarkers in the cerebrospinal fluid (CSF) and blood: amyloid beta peptides, tau protein, and its phosphorylated form (pTau). CSF analysis is an increasingly important tool for early and differential diagnosis of dementia syndromes. Although lumbar puncture is a mildly invasive procedure with a low incidence of complications, establishing blood assays capable of reliably measuring NDD biomarkers is an aim of several studies worldwide.
Lewczuk
Piotr
P
Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, Schwabachanlage 6, Erlangen, Germany.
Hornegger
Joachim
J
Zimmermann
Rüdiger
R
Otto
Markus
M
Wiltfang
Jens
J
Kornhuber
Johannes
J
D016229:Amyloid beta-Peptides / Q000097:blood / Q000134:cerebrospinal fluid; D000818:Animals; D003704:Dementia / Q000097:blood / Q000134:cerebrospinal fluid / Q000175:diagnosis; D006801:Humans; D009448:Neurochemistry; D010766:Phosphorylation; D016875:tau Proteins / Q000097:blood / Q000134:cerebrospinal fluid
D016229:Amyloid beta-Peptides; D016875:tau Proteins