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The formation of a metal-complex of copper(II) with vancomycin, an antibiotic active towards Gram-positive bacteria, has been proved by spectrophotometric, polarographic and potentiometric methods. In particular, the half-wave reduction potentials and voltamperograms indicate the stoichiometry of the addition compound and the equilibrium constant. This complex has been used for determination of vancomycin by a continuous flow method with copper(II) and amperometric detection in a polarographic cell of thin-layer type.
Chabenat
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Laboratoire de Chimie Analytique Pharmaceutique, U.E.R. de Médecine et Pharmacie de Rouen, Avenue de L'Université, 76800 St Etienne-du-Rouvray, France.
Andre
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Boucly
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