[Antimicrobial effects of erythromycin microspheres against Mycoplasma Pneumoniae in rats].
OBJECTIVE
To evaluate the antimicrobial effects of erythromycin microspheres against Mycoplasma pneumoniae in rats.


METHODS
With erythromycin lactobionate as the positive control, erythromycin microspheres at 3 non-toxic doses (0.1, 0.5, and 1.2 g.kg(-1).d(-1)) were administered intragastrically for 6 consecutive days in Wistar rats with Mycoplasma pneumoniae infection. The general condition and lung index of the rats were observed and measured to assess the therapeutic effects of the treatments against Mycoplasma pneumoniae infection.


RESULTS
The erythromycin microspheres at 0.1, 0.5, 1.2 g.kg(-1).d(-1) significantly alleviated the symptoms of the rats infected with Mycoplasma pneumoniae and reduced the pulmonary index of the infected rats from 1.75 to 1.45, 1.38 and 1.25, respectively (P < 0.01). An obvious dosage-effect relationship was noted between the dose of erythromycin microsphere and the tissue pathologies due to the infection.


CONCLUSIONS
Erythromycin microspheres possess strong activity against Mycoplasma pneumoniae in rats.
Li
Tao
T
Department of Pharmacy, People's Hospital of Guangdong Province, Guangzhou 510080, China.
Wen
Jing
J
Jiang
Wen-ling
WL
Gong
Ming
M
Yang
Zhan-qiu
ZQ
Xiao
Hong
H
D000818:Animals; D004917:Erythromycin / Q000008:administration & dosage*; D008297:Male; D008863:Microspheres; D009177:Mycoplasma pneumoniae / Q000187:drug effects*; D011019:Pneumonia, Mycoplasma / Q000188:drug therapy*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D004917:Erythromycin