title: Amperometric determination of 6-mercaptopurine on functionalized multi-wall carbon nanotubes modified electrode by liquid chromatography coupled with microdialysis and its application to pharmacokinetics in rabbit.
abstract: In this paper, multi-wall carbon nanotubes functionalized with carboxylic groups modified electrode (MWNT-COOH CME) was fabricated. This chemically modified electrode (CME) can be used as the working electrode in the liquid chromatography for the determination of 6-mercaptopurine (6-MP). The results indicate that the CME exhibits efficiently electrocatalytic oxidation for 6-MP with relatively high sensitivity, stability and long-life. The peak currents of 6-MP are linear to its concentrations ranging from 4.0 x 10(-7) to 1.0 x 10(-4) mol l(-1) with the calculated detection limit (S/N=3) of 2.0 x 10(-7) mol l(-1). Coupled with microdialysis, the method has been successfully applied to the pharmacokinetic study of 6-MP in rabbit blood. This method provides a fast, sensible and simple technique for the pharmacokinetic study of 6-MP in vivo.
authors.affiliation: Department of Chemistry, East China Normal University, Shanghai, China. caoxuni@sohu.com
authors.forename: Xu-Ni
authors.initials: XN
authors.lastname: Cao
authors.forename: Li
authors.initials: L
authors.lastname: Lin
authors.forename: Yu-Yan
authors.initials: YY
authors.lastname: Zhou
authors.forename: Guo-Yue
authors.initials: GY
authors.lastname: Shi
authors.forename: Wen
authors.initials: W
authors.lastname: Zhang
authors.forename: Katsunobu
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Li-Tong
authors.initials: LT
authors.lastname: Jin