Study of the tautomeric forms of 3,4-dihydroxyphenylacetic acid by carbon-13 nuclear magnetic resonance spectroscopy.
The pH-dependent (13)C chemical shifts indicate an approximately 1:1 ratio of the 3-OH:4-OH tautomeric forms of singly dissociated 3,4-dihydroxyphenylacetic acid. It is found that the (13)C chemical-shift method is an effective technique for determining tautomeric forms from pK values.
Ishimitsu
T
T
Kyoto College of Pharmacy, Kyoto 607, Japan.
Fujiwara
Y
Y
Hirose
S
S