title: Influence of the time interval between hysteroscopy, dilation and curettage, and hysterectomy on survival in patients with endometrial cancer.
abstract: OBJECTIVE
  To evaluate whether a prolonged time interval between dilation and curettage (D&C) and hysterectomy has an effect on survival in patients with surgically treated endometrial cancer.
  
  
  METHODS
  In this multicenter study, time between D&C and hysterectomy was correlated to clinical data in 344 surgically staged patients with endometrioid endometrial cancer.
  
  
  RESULTS
  The median (interquartile range) interval between D&C and hysterectomy in patients with endometrial cancer was 23 (13-34) days. In a univariable survival analysis, International Federation of Gynecology and Obstetrics (FIGO) tumor stage (P<.001, P<.001), tumor grade (P<.001, P<.001), and patients' age (P<.001, P<.001), but not time interval from D&C to hysterectomy (P=.06, P=.07) were associated with disease-free and overall survival, respectively. In a multivariable Cox regression model, FIGO tumor stage (P<.001, P<.001), and patients' age (P<.001, P<.001) but not tumor grade (P=.4, P=.2) or time interval between D&C and hysterectomy (P=.5, P=.8) were independent prognostic factors for disease-free and overall survival, respectively.
  
  
  CONCLUSIONS
  We were not able to show that a prolonged time interval between D&C and hysterectomy has a significant effect on the prognosis of patients with endometrial cancer.
  
  
  METHODS
  II.
authors.affiliation: Department of Obstetrics, Medical University of Vienna, Vienna, Austria. lukas.hefler@meduniwien.ac.at
authors.forename: Lukas
authors.initials: L
authors.lastname: Hefler
authors.forename: Heinz
authors.initials: H
authors.lastname: Leipold
authors.forename: Stefan
authors.initials: S
authors.lastname: Hinterberger
authors.forename: Nicole
authors.initials: N
authors.lastname: Concin
authors.forename: Renate
authors.initials: R
authors.lastname: Klotz
authors.forename: Alexander
authors.initials: A
authors.lastname: Reinthaller
mesh_terms: D000368:Aged; D004107:Dilatation and Curettage; D018572:Disease-Free Survival; D016889:Endometrial Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D016016:Proportional Hazards Models; D013997:Time Factors