A new cytotoxic guaianolide from Chrysanthemum boreale.
A new cytotoxic guaianolide was isolated from Chrysanthemum boreale Makino. The structure of guaianolide was elucidated as 8-acetoxy-4,10-dihydroxy-2,11(13)-guaiadiene-12,6-olide (1). Compound 1 exhibited cytotoxic activity (IC(50)< or =4 microg/ml) against all five human cancer cell lines tested.
Park
Ki Hun
KH
Division of Applied Life Science (BK21 program), EB-NCRC, Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 660-701, Republic of Korea.
Yang
Min Suk
MS
Park
Moon Ki
MK
Kim
Sang Chan
SC
Yang
Chae Ha
CH
Park
Sook Jahr
SJ
Lee
Jong Rok
JR
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D031202:Chrysanthemum / Q000737:chemistry*; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D045789:Sesquiterpenes, Guaiane / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*
C539598:8-acetoxy-4,10-dihydroxy-2,11(13)-guaiadiene-12,6-olide; D000972:Antineoplastic Agents, Phytogenic; D003603:Cytotoxins; D010936:Plant Extracts; D045789:Sesquiterpenes, Guaiane