Phylogenetics and pathogenesis of early avian influenza viruses (H5N1), Nigeria.
Three highly pathogenic avian influenza subtype H5N1 and 4 Newcastle disease viruses were isolated from sick or dead chickens in southwestern Nigeria. Sequencing and phylogenetic analysis placed them within H5N1 subclade 2.2.2. Intravenous and intranasal pathogenicity tests produced systemic disease with vascular endothelial cell tropism in chickens.
Aiki-Raji
Comfort O
CO
University of Ibadan, Ibadan, Nigeria.
Aguilar
Patricia V
PV
Kwon
Yong-Kuk
YK
Goetz
Sue
S
Suarez
David L
DL
Jethra
Aashish I
AI
Nash
Oyekanmi
O
Adeyefa
Christopher A O
CA
Adu
Festus D
FD
Swayne
David
D
Basler
Christopher F
CF
D000818:Animals; D001921:Brain / Q000473:pathology; D002645:Chickens / Q000821:virology; D004730:Endothelium, Vascular / Q000821:virology; D007249:Inflammation / Q000473:pathology; D053124:Influenza A Virus, H5N1 Subtype / Q000145:classification* / Q000302:isolation & purification / Q000472:pathogenicity*; D005585:Influenza in Birds / Q000453:epidemiology* / Q000473:pathology / Q000821:virology*; D008168:Lung / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D009549:Nigeria / Q000453:epidemiology; D010802:Phylogeny; D014774:Virulence