title: Synthesis of chiral organocatalysts derived from aziridines: application in asymmetric aldol reaction.
abstract: We report the synthesis of a new series of highly efficient chiral organocatalysts derived via the regio- and stereoselective ring opening of chiral aziridines with azide anions. The catalysts have proved to be very efficient for a direct asymmetric aldol reaction, both with cyclic as well as acyclic ketones in brine with 2 mol % of catalyst loading, and afforded the products in excellent yields (up to 99%) and enantioselectivities (up to >99%). The chiral aldol adduct obtained has further been converted to a chiral azetidine ring via a convenient pathway.
authors.affiliation: Department of Chemistry, Indian Institute of Technology, Kanpur 208016, India.
authors.forename: Shikha
authors.initials: S
authors.lastname: Gandhi
authors.forename: Vinod K
authors.initials: VK
authors.lastname: Singh