title: 18F-fluoro-2-deoxy-D-glucose standardized uptake value in cavitating non-small-cell lung carcinoma.
abstract: OBJECTIVE
  Cavitation in lung tumours has been considered as a specific clinical subentity related to worse prognosis and reduced survival. This study was performed to assess glycolysis as maximum standardized uptake value (SUVmax) on F-fluoro-2-deoxy-D-glucose PET imaging, a known prognostic factor in lung cancer and an index of tumour aggression in cavitated tumours.
  
  
  METHODS
  Thirty-one patients with biopsy-proved, cavitated, non-small cell lung cancer (NSCLC) underwent PET/computed tomography staging scans. SUVmax readings were compared with those of 37 patients with solid NSCLC tumours but with similar staging. Maximum tumour diameters were recorded together with survival at 2 years.
  
  
  RESULTS
  Mean SUVmax, corrected for body weight, of the cavitated tumours was 14+/-6.8, compared with 13.5+/-10.8 for the solid tumours. No significant difference on paired t-tests was seen (P=0.83). The maximum diameter of the tumour was significantly greater (P<0.05) for the cavitated tumours (5.8+/-2.4 cm) than for solid tumours (4.4+/-2.4 cm). Six patients with cavitated tumours died at 2 years compared with 11 with solid tumours; no significant difference in survival (two-sided P value=0.48, Fisher's exact test) was observed between patients with cavitated tumours and those with solid tumours.
  
  
  CONCLUSIONS
  These findings do not support cavitation as a separate prognostic feature in NSCLC. Only tumour diameter was increased overall in the cavitated group. No increased glycolysis on PET/computed tomography imaging, relative to solid tumours, was seen and overall survival at 2 years seemed similar between the two groups.
authors.affiliation: Royal Preston Hospital, Sharoe Green Lane, Fulwood Preston, UK. John.Coffey@lthtr.nhs.uk
authors.forename: John P
authors.initials: JP
authors.lastname: Coffey
authors.forename: J C
authors.initials: JC
authors.lastname: Hill
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology*; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism*; D006019:Glycolysis; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography; D011379:Prognosis; D012015:Reference Standards; D014057:Tomography, X-Ray Computed
chemical_list: D019788:Fluorodeoxyglucose F18