title: Metastasis and AKT activation.
abstract: Metastasis, responsible for 90% of cancer patient deaths, is an inefficient process because many tumor cells die. The survival of metastatic tumor cells should be considered as a critical therapeutic target. This review provides a new perspective regarding the role of AKT in tumor survival, and the rationale to target AKT in anti-metastasis therapies.
authors.affiliation: Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA. ssheng@med.wayne.edu
authors.forename: Shijie
authors.initials: S
authors.lastname: Sheng
authors.forename: Meng
authors.initials: M
authors.lastname: Qiao
authors.forename: Arthur B
authors.initials: AB
authors.lastname: Pardee
mesh_terms: D004789:Enzyme Activation; D006801:Humans; D009362:Neoplasm Metastasis / Q000473:pathology*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*
chemical_list: D051057:Proto-Oncogene Proteins c-akt