Long-term consequences of polycystic ovary syndrome on cardiovascular risk.
Most available data suggest that the prevalence of cardiovascular diseases in women with polycystic ovary syndrome (PCOS) is smaller than expected based on risk calculations during fertile years; therefore, more studies are needed on long-term cardiovascular consequences. Evidence is accumulating that postmenopausal women with PCOS have an increased risk of cerebrovascular events and cardiovascular morbidity. These events are partially related to persisting hyperandrogenism but are mostly correlated with excessive body weight (mainly visceral obesity); this suggests that our best long-term strategy is to ensure that women with PCOS are informed about their high risk for metabolic and cardiovascular diseases.
Rizzo
Manfredi
M
Department of Internal Medicine and Emerging Diseases, University of Palermo, Palermo, Italy. mrizzo@unipa.it
Berneis
Kaspar
K
Spinas
Giatgen
G
Rini
Giovam Battista
GB
Carmina
Enrico
E
D052242:Adiponectin / Q000097:blood; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood / Q000502:physiology*; D000728:Androgens / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D048909:Diabetes Complications / Q000097:blood / Q000150:complications / Q000503:physiopathology; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood / Q000150:complications / Q000503:physiopathology; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications / Q000503:physiopathology; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D012307:Risk Factors
D052242:Adiponectin; D000728:Androgens; D015415:Biomarkers; D002097:C-Reactive Protein