Hepatitis C virus and inflammatory bowel disease.
Gastroenterologists frequently treat patients with complex illnesses such as chronic hepatitis C infections and inflammatory bowel disease (IBD). Occasionally, a patient will present with these two diseases which behave very differently and the treatment for one may potentially exacerbate the other. The purpose of this article is to review the current literature regarding hepatitis C virus therapy in the setting of IBD as well as the effects of common IBD therapies on the hepatitis C virus. Based on limited data, anti-viral therapy is probably safe in patients with well-controlled IBD, but there might be a risk of causing new onset of IBD. Also, it does not appear that the commonly used medications for IBD have much of an effect on the hepatitis C virus (HCV) or its course.
Horn
Todd L
TL
Department of Internal Medicine, Division of Digestive Diseases and Nutrition, University of Kentucky, Lexington, KY 40536, USA.
Reynolds
Joel
J
de Villiers
Willem
W
Peña
Luis R
LR
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D006526:Hepatitis C / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015212:Inflammatory Bowel Diseases / Q000150:complications* / Q000188:drug therapy; D012307:Risk Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000998:Antiviral Agents; D007166:Immunosuppressive Agents