title: The synchronous occurrence of squamous cell carcinoma and gastrointestinal stromal tumor (GIST) at esophageal site.
abstract: BACKGROUND
  Esophageal squamous cell carcinoma is a relative common malignancy with a very poor prognosis, even adopting an integrated and multidisciplinary approach. According to the literature, gastrointestinal stromal tumors (GISTs) rarely originate from the esophagus. Moreover there are not reports of synchronous occurrence of squamous cell carcinoma and GIST at esophageal site.
  
  
  METHODS
  We describe a case of a 74 year old patient who underwent surgery for squamous cell carcinoma of the lower third of the esophagus with an incidental pathologic diagnosis of a concomitant GIST in the thoracic tract.
  
  
  CONCLUSIONS
  In literature there is no evidence of concomitant squamous carcinoma and GIST of the thoracic esophagus, even if esophageal GISTs are sometimes described. The occasional finding of this neoplastic lesion underlines the importance of a carefully pathological diagnosis for its identification. Surgery, followed by a multidisciplinary approach remains the first-line treatment in both squamous and stromal neoplasm.
authors.affiliation: Department of Experimental Medicine, University of Rome "Sapienza", Rome, Italy. gianpaolo.spinelli@uniroma1.it
authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Spinelli
authors.forename: Evelina
authors.initials: E
authors.lastname: Miele
authors.forename: Federica
authors.initials: F
authors.lastname: Tomao
authors.forename: Luigi
authors.initials: L
authors.lastname: Rossi
authors.forename: Giulia
authors.initials: G
authors.lastname: Pasciuti
authors.forename: Angelo
authors.initials: A
authors.lastname: Zullo
authors.forename: Federica
authors.initials: F
authors.lastname: Zoratto
authors.forename: Jose
authors.initials: J
authors.lastname: Nunnari
authors.forename: Giovanni Codacci
authors.initials: GC
authors.lastname: Pisanelli
authors.forename: Silverio
authors.initials: S
authors.lastname: Tomao
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery