[The role of glycosylases of the base excision DNA repair in pathogenesis of hereditary and infectious human diseases].
DNA glycosylases are enzymes that initiate base excision repair, a process of removal of damaged bases from the cellular DNA. Recent data show that variants of two human DNA glycosylases, MUTYH and OGG1, are associated with an increased risk of cancer. In addition, activities of various DNA glycosylases have been implicated in protection of humans from neurodegenerative diseases, immune disorders and viral infections. On the other hand, DNA glycosylases from pathogenic microorganisms help them to avoid the host defensive systems. Thus, DNA glycosylases represent both potential therapeutic agents and drug targets.
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D000595:Amino Acid Sequence; D001424:Bacterial Infections / Q000201:enzymology* / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D004249:DNA Damage / Q000235:genetics / Q000502:physiology; D045647:DNA Glycosylases / Q000235:genetics / Q000502:physiology*; D004260:DNA Repair / Q000235:genetics / Q000502:physiology*; D030342:Genetic Diseases, Inborn / Q000201:enzymology* / Q000235:genetics; D006801:Humans; D007154:Immune System Diseases / Q000201:enzymology / Q000235:genetics; D008969:Molecular Sequence Data; D009154:Mutation; D019636:Neurodegenerative Diseases / Q000201:enzymology / Q000235:genetics; D014777:Virus Diseases / Q000201:enzymology* / Q000235:genetics
D045647:DNA Glycosylases; C061738:mutY adenine glycosylase; C479058:oxoguanine glycosylase 1, human