Multiple leiomyoma as a possible sign of aggressive renal cancer.
A 53-year-old Chinese man presented with a history of painful lesions on the chest of 20 years' duration. He experienced sharp pain especially on touching and after spicy food. The lesions were stable with no increase in size or number. He was otherwise well. There was no significant family history. Physical examination revealed multiple, grouped, pink papules on the left chest, extending to the right back in a segmental distribution, each measuring 2-5 mm (Figs 1 and 2). They appeared pearly and keloid-like, and had a firm consistency. A punch biopsy specimen was obtained and sent for histopathologic examination (Figs 3 and 4). This revealed a circumscribed, nonencapsulated tumor with a Grenz zone below the epidermis. It was composed of interlacing fascicles of bland spindle cells with elongated nuclei and blunt ends, typical of a cutaneous leiomyoma. The patient subsequently underwent computed tomography of the abdomen, which did not show any renal or abdominal masses.
Chia
Min-Wee
MW
Division of Dermatology, Changi General Hospital, and National Skin Centre, Singapore. chia_min_wee@yahoo.com.sg
Tay
Yong-Kwang
YK
Tan
Suat-Hoon
SH
D002292:Carcinoma, Renal Cell / Q000175:diagnosis / Q000235:genetics*; D005649:Fumarate Hydratase / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D018095:Germ-Line Mutation; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000235:genetics*; D007889:Leiomyoma / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000473:pathology*; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology*; D013909:Thorax
D005649:Fumarate Hydratase