title: Stimulation-induced parkinsonism after posteroventral deep brain stimulation of the globus pallidus internus for craniocervical dystonia.
abstract: The authors report on a patient with craniocervical dystonia who was treated with bilateral GPi stimulation, with excellent improvement in dystonia but at the cost of stimulation-induced, reversible parkinsonism. Stimulation through ventral contacts resulted in maximal relief of craniocervical dystonia but induced considerable hypophonia, bradykinesia, rigidity, freezing, and impaired postural reflexes. Stimulation through dorsal contacts alleviated parkinsonism, but resulted in the return of dystonia. No stimulation parameters could alleviate the dystonia without inducing parkinsonism over the course of his 4-year follow-up.
authors.affiliation: Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.
authors.forename: S Elizabeth
authors.initials: SE
authors.lastname: Zauber
authors.forename: Nidhi
authors.initials: N
authors.lastname: Watson
authors.forename: Cynthia L
authors.initials: CL
authors.lastname: Comella
authors.forename: Roy A E
authors.initials: RA
authors.lastname: Bakay
authors.forename: Leo Verhagen
authors.initials: LV
authors.lastname: Metman
mesh_terms: D000328:Adult; D001764:Blepharospasm / Q000503:physiopathology / Q000628:therapy*; D001931:Brain Mapping; D046690:Deep Brain Stimulation / Q000009:adverse effects*; D004292:Dominance, Cerebral / Q000502:physiology; D004401:Dysarthria / Q000209:etiology / Q000503:physiopathology; D005500:Follow-Up Studies; D005917:Globus Pallidus / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008839:Microelectrodes; D009048:Motor Skills / Q000502:physiology; D009460:Neurologic Examination; D020734:Parkinsonian Disorders / Q000209:etiology* / Q000503:physiopathology; D011183:Postoperative Complications / Q000209:etiology* / Q000503:physiopathology; D014103:Torticollis / Q000503:physiopathology / Q000628:therapy*