[Molecular aspects of obesity and related-pathologies].
The structure of human genetic machinery aimed at energy homeostasis has been set-up to face food deficiency rather than availability of a larger amount of calories compared with those needed for activities and works characterized by a little expenditure of energy. A epidemiologic-like, global-extended trend of obesity growth is observable, a condition associated with other pathologies that increase mobility and mortality in all ranges of ages. A correct management of obesity is a global challenge that involves both health improvement and socioeconomic aspects (i.e. costs sustained for management of obesity-linked pathologies, such the cardiovascular diseases, the type 2 diabetes as well as some type of tumors or neurologic diseases). This article analyzes recent scientific advancements on the mechanisms linking obesity to type 2 diabetes as well as the adipose tissue and intestinal apparatus' molecular mechanisms that control the energy balance.
Buonsanti
G
G
Laboratorio di Analisi Cliniche del dott. A. Montemurro & C. S.a.s., Matera, Italia. giovanni.buonsanti@gmail.com
D000273:Adipose Tissue / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology / Q000378:metabolism*; D004734:Energy Metabolism / Q000502:physiology; D005768:Gastrointestinal Hormones / Q000502:physiology*; D006801:Humans; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000378:metabolism*; D009765:Obesity / Q000150:complications / Q000378:metabolism*
D005768:Gastrointestinal Hormones