Serum levels of insulin-like growth factor-I are positively associated with functional outcome after hip fracture in elderly women.
OBJECTIVE
To investigate the association between serum levels of insulin-like growth factor-I (IGF-I) and functional outcome in hip-fracture women.


METHODS
We investigated 171 of 188 women admitted consecutively to a rehabilitation hospital after hip fracture. IGF-I serum levels were assessed by using an automated chemiluminescence immunoassay 21.3 +/- 6.1 days (mean +/- SD) after fracture occurrence. Functional outcome was assessed using Barthel index scores.


RESULTS
At a Spearman rank test we observed a significant positive correlation between IGF-I levels and both Barthel index scores at discharge from inpatient rehabilitation (rho = 0.213; P = 0.005) and changes in Barthel index scores during rehabilitation (rho = 0.222; P = 0.004). At multiple regression, a significant association between IGF-I and both functional scores and their changes during rehabilitation was found after adjustment for several potential confounders, including age, cognitive impairment, pressure ulcers, neurologic impairment, infections, Barthel index score at admission to rehabilitation, and length of stay in hospital (P < 0.05). Overall, the panel of prognostic factors accounted for 55% of the variance in the functional score and 31% of the variance in its change during rehabilitation.


CONCLUSIONS
IGF-I serum levels were significantly associated with ability to function after hip fracture in women.
Di Monaco
Marco
M
Osteoporosis Research Center, Presidio Sanitario San Camillo, Torino, Italy.
Vallero
Fulvia
F
Di Monaco
Roberto
R
Tappero
Rosa
R
Cavanna
Alberto
A
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003072:Cognition Disorders / Q000453:epidemiology; D005260:Female; D006620:Hip Fractures / Q000097:blood* / Q000453:epidemiology / Q000534:rehabilitation; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D007902:Length of Stay; D008163:Luminescent Measurements; D020127:Recovery of Function / Q000502:physiology*; D012044:Regression Analysis; D012680:Sensitivity and Specificity
D007334:Insulin-Like Growth Factor I