title: Platelet-activating factor antagonistic activity and(13)C NMR assignment of pregomisin and chamigrenal fromSchisandra chinensis.
abstract: In the course of searching for PAF receptor antagonists, pregomisin (1) and chamigrenal (2) were isolated from the fruits ofSchizandra chinensis Baill by the bioactivity-guided isolation. Both compounds showed PAF antagonistic activity and the IC(50) values were 4.8x10(-5) M and 1.2x10(-4) M, respectively. In addition, the(13)C NMR assignments of1 and2 using DEPT, HMQC, COLOC and HMBC were reported for the first time.
authors.affiliation: Natural Product Biosynthesis Research Unit, Korea Research Institute of Bioscience & Biotechnology, Yusong, P.O. Box 115, 305-600, Taejon, Korea.
authors.forename: I S
authors.initials: IS
authors.lastname: Lee
authors.forename: K Y
authors.initials: KY
authors.lastname: Jung
authors.forename: S R
authors.initials: SR
authors.lastname: Oh
authors.forename: D S
authors.initials: DS
authors.lastname: Kim
authors.forename: J H
authors.initials: JH
authors.lastname: Kim
authors.forename: J J
authors.initials: JJ
authors.lastname: Lee
authors.forename: H K
authors.initials: HK
authors.lastname: Lee
authors.forename: S H
authors.initials: SH
authors.lastname: Lee
authors.forename: E H
authors.initials: EH
authors.lastname: Kim
authors.forename: C
authors.initials: C
authors.lastname: Cheong