title: The autistic neuron: troubled translation?
abstract: Autism is a complex genetic disorder, but single-gene disorders with a high prevalence of autism offer insight into its pathogenesis. Recent evidence suggests that some molecular defects in autism may interfere with the mechanisms of synaptic protein synthesis. We propose that aberrant synaptic protein synthesis may represent one possible pathway leading to autistic phenotypes, including cognitive impairment and savant abilities.
authors.affiliation: Center for Human Genetic Research, Harvard-Partners Center for Genetics and Genomics, Massachusetts General Hospital, Program in Neuroscience and Department of Neurology, Harvard Medical School, Boston, MA 02115, USA. kelleher@helix.mgh.harvard.edu
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Kelleher
authors.forename: Mark F
authors.initials: MF
authors.lastname: Bear
mesh_terms: D000818:Animals; D001321:Autistic Disorder / Q000378:metabolism*; D003071:Cognition; D006801:Humans; D051379:Mice; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009473:Neuronal Plasticity; D009474:Neurons / Q000378:metabolism*; D014176:Protein Biosynthesis; D013569:Synapses / Q000378:metabolism
chemical_list: D009419:Nerve Tissue Proteins