[Acute respiratory distress syndrome as the presenting manifestation of an antisynthetase syndrome].
The antisynthetase syndrome is a subgroup of idiopathic inflammatory muscle diseases. Its characteristics are interstitial lung disease, myositis, polyarthritis, mechanic's hand like cutaneous involvement, and the presence of antisynthetase antibodies (anti-Jo1). The lung disease is the presenting feature in 50% of cases. We report a patient with an antisynthetase syndrome, revealed by an acute respiratory distress syndrome. This patient was already followed-up for a scleroderma and presented a probable overlap syndrome. The disease course was favourable with anti-CD20 therapy.
Fagedet
D
D
Clinique de médecine interne, CHU de Grenoble, BP 217, 38700 la Tronche cedex 09, France. dfagedet@yahoo.fr
Bernard
S
S
Colombe
B
B
Bosseray
A
A
Baudet
A
A
Bouillet
L
L
Massot
C
C
D000604:Amino Acyl-tRNA Synthetases / Q000276:immunology; D001323:Autoantibodies / Q000097:blood; D005260:Female; D006801:Humans; D008875:Middle Aged; D017285:Polymyositis / Q000175:diagnosis* / Q000276:immunology; D012128:Respiratory Distress Syndrome / Q000209:etiology*; D013577:Syndrome
D001323:Autoantibodies; D000604:Amino Acyl-tRNA Synthetases