A syndrome resembling Bartter's syndrome in sarcoidosis.
Acquired Bartter-like syndrome, albeit rare, has not been reported to be associated with sarcoidosis. We describe the case of a 32-year-old male patient who presented with progressive muscular weakness of both lower extremities. Profound hypokalaemia associated with renal (K(+)) wasting, bilateral nephrocalcinosis and high plasma renin activity resembled Bartter's syndrome (BS). Both mediastinal lymph node and renal biopsy demonstrated sarcoidosis with non-caseating granuloma. Genetic testing responsible for hereditary BS or Gitelman's syndrome (GS) was negative. Hypokalaemia was well controlled with the administration of spironolactone with oral steroids and KCl. Early recognition and prompt treatment of sarcoidosis-associated Bartter-like syndrome avoids unnecessary complications.
Yu
Tung-Min
TM
Division of Nephrology, Taichung Veterans General Hospital, Taiwan.
Lin
Shih-Hua
SH
Ya-Wen
Chuang
C
Wen
Mei-Chin
MC
Chen
Yi-Hsing
YH
Cheng
Chi-Hung
CH
Chen
Cheng-Hsu
CH
Chin
Chung-Shi
CS
Shu
Kuo-Hsiung
KH
D000328:Adult; D001477:Bartter Syndrome / Q000145:classification / Q000150:complications* / Q000175:diagnosis* / Q000209:etiology; D003937:Diagnosis, Differential; D006801:Humans; D007008:Hypokalemia / Q000150:complications / Q000188:drug therapy; D007674:Kidney Diseases / Q000150:complications* / Q000473:pathology; D008297:Male; D009397:Nephrocalcinosis / Q000150:complications; D012083:Renin / Q000097:blood; D012507:Sarcoidosis / Q000150:complications* / Q000473:pathology
D012083:Renin