title: Highly (E)-selective Wadsworth-Emmons reactions promoted by methylmagnesium bromide.
abstract: An experimentally simple protocol for the very highly (E)-selective Wadsworth-Emmons reaction [(E):(Z) selectivities in excess of 180:1 in some cases] of a range of straight-chain and branched aliphatic, substituted aromatic, and base-sensitive aldehydes via reaction with an alkyl diethylphosphonoacetate and MeMgBr is reported.
authors.affiliation: Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.
authors.forename: Timothy D W
authors.initials: TD
authors.lastname: Claridge
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Davies
authors.forename: James A
authors.initials: JA
authors.lastname: Lee
authors.forename: Rebecca L
authors.initials: RL
authors.lastname: Nicholson
authors.forename: Paul M
authors.initials: PM
authors.lastname: Roberts
authors.forename: Angela J
authors.initials: AJ
authors.lastname: Russell
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Smith
authors.forename: Steven M
authors.initials: SM
authors.lastname: Toms