Amniocentesis and mother-to-child human immunodeficiency virus transmission in the Agence Nationale de Recherches sur le SIDA et les Hépatites Virales French Perinatal Cohort.
OBJECTIVE
The objective of the study was to investigate whether performing an amniocentesis increased mother-to-child transmission of human immunodeficiency virus (HIV)-1 (MTCT).


METHODS
We studied HIV -1 infected mothers and their children enrolled in the multicenter French Perinatal HIV Cohort from 1985 to 2006.


RESULTS
One hundred sixty-six amniocenteses were performed among 9302 singleton pregnancies, the proportion increasing from 1.0% before 2001 to 4.7% in 2005-2006. Use of highly active antiretroviral therapy (HAART) was more frequent in the amniocentesis group (58.4% vs 33.2%). MTCT tended to be higher in the amniocentesis group, among mothers who received no antiretroviral agents (25.0%; 3/12 vs 16.2%; 343/2113; P = .41) as well as among mothers receiving zidovudine monotherapy or a double-nucleoside reverse transcriptase inhibitor combination (6.1%; 3/49 vs 3.3%; 117/3556; P = .22), but the difference was not significant. Among 81 mothers receiving HAART, there was no case of MTCT.


CONCLUSIONS
Our results suggest that amniocentesis is not a major risk factor for mother-to-child transmission in mothers treated with effective antiretroviral therapy.
Mandelbrot
Laurent
L
Assistance Publique-Hôpitaux de Paris (AP-HP), Service de Gynecologie-Obstetrique, Hôpital Louis Mourier, Colombes, and Université Paris 7-Diderot, Paris, France.
Jasseron
Carine
C
Ekoukou
Dieudonné
D
Batallan
Agnès
A
Bongain
André
A
Pannier
Emmanuelle
E
Blanche
Stéphane
S
Tubiana
Roland
R
Rouzioux
Christine
C
Warszawski
Josiane
J
D000328:Adult; D000649:Amniocentesis / Q000009:adverse effects*; D015331:Cohort Studies; D005260:Female; D005602:France; D015658:HIV Infections / Q000209:etiology / Q000635:transmission*; D015497:HIV-1; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000209:etiology*; D012307:Risk Factors; D055815:Young Adult