[Pharmaceutical significance of amorphous materials].
The solid-state characteristics play an important role during the development and manufacture of medicinal products, because they may influence the effectiveness, stability as well as the processibility of pharmaceutical systems. The amorphous state is critical in determining the solid-state physical and chemical properties of many pharmaceutical dosage forms. The main reason of the growing interest toward amorphous materials is the need to improve the bioavailability of compounds with poor aqueous solubility. However the disordered structure of higher energy state assures increased solubility and faster dissolution rate, the amorphous state is a non-equilibrium state. Materials often go through spontaneous transformations towards lower energy equilibrium states.
Antal
István
I
Semmelweis Egyetem, Gyógyszerészeti Intézet, Budapest, Hogyes E. u. 7.-1092.
Zelkó
Romána
R
D001682:Biological Availability; D003461:Crystallography; D004355:Drug Stability; D008958:Models, Molecular; D004364:Pharmaceutical Preparations; D013678:Technology, Pharmaceutical / Q000379:methods; D013816:Thermodynamics
D004364:Pharmaceutical Preparations