title: Cytotoxic polyketides from a marine-derived fungus Aspergillus glaucus.
abstract: Eight new aromatic polyketides (2, 4-6, 8, 14, 16, and 17) together with eight known analogues (3, 7, 9-13, and 15) were isolated from the marine-derived fungus Aspergillus glaucus. The structures and stereochemistry of the new compounds were elucidated by spectroscopic and chemical methods, and their cytotoxicities were evaluated against the HL-60 and A-549 cell lines.
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
authors.forename: Lin
authors.initials: L
authors.lastname: Du
authors.forename: Tianjiao
authors.initials: T
authors.lastname: Zhu
authors.forename: Hongbing
authors.initials: H
authors.lastname: Liu
authors.forename: Yuchun
authors.initials: Y
authors.lastname: Fang
authors.forename: Weiming
authors.initials: W
authors.lastname: Zhu
authors.forename: Qianqun
authors.initials: Q
authors.lastname: Gu
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001230:Aspergillus / Q000737:chemistry*; D002681:China; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D061065:Polyketides