title: No effect of six weeks of treatment with escitalopram on mood in healthy volunteers--irrespective of genotype for the promoter of the serotonin transporter.
abstract: Data on emotional effects of chronic antidepressants in normal subjects are scarce and contradictory. Thirty healthy men were given 10 mg/day of escitalopram for 6 weeks in a double-blind, placebo-controlled, within-subject cross-over study. No significant effect on negative affect, positive affect, or state anxiety was detected, irrespective of serotonin transporter gene-linked polymorphism.
authors.affiliation: Department of Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, Hamburg, Germany. kellner@uke.uni-hamburg.de
authors.forename: Michael
authors.initials: M
authors.lastname: Kellner
authors.forename: Cüneyt
authors.initials: C
authors.lastname: Demiralay
authors.forename: Christoph
authors.initials: C
authors.lastname: Muhtz
authors.forename: Jana
authors.initials: J
authors.lastname: Husemann
authors.forename: Wiebke
authors.initials: W
authors.lastname: Kölsch
authors.forename: Christoph
authors.initials: C
authors.lastname: Hiemke
authors.forename: Alexander
authors.initials: A
authors.lastname: Yassouridis
authors.forename: Klaus
authors.initials: K
authors.lastname: Wiedemann
mesh_terms: D000328:Adult; D000339:Affect / Q000187:drug effects*; D000483:Alleles; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology*; D015283:Citalopram / Q000494:pharmacology*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008297:Male; D011401:Promoter Regions, Genetic / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D018687:Antidepressive Agents, Second-Generation; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D015283:Citalopram