title: Association of IL-6 gene polymorphism with the outcome of allogeneic haematopoietic stem cell transplantation in Czech patients.
abstract: Interleukin-6 (IL-6) is an important pro-inflammatory mediator implicated in immune-mediated complications of allogeneic haematopoietic stem cell transplantation (aHSCT). In accord with previous reports, this preliminary study on 56 donor-recipient pairs revealed IL-6-174 single nucleotide polymorphisms as a risk factor for the development of acute graft-versus-host disease and decreased survival after aHSCT.
authors.affiliation: Department of Immunology, Tissue Typing Laboratory, Palacky University Olomouc, Czech Republic.
authors.forename: Z
authors.initials: Z
authors.lastname: Ambruzova
authors.forename: F
authors.initials: F
authors.lastname: Mrazek
authors.forename: L
authors.initials: L
authors.lastname: Raida
authors.forename: E
authors.initials: E
authors.lastname: Faber
authors.forename: J
authors.initials: J
authors.lastname: Onderkova
authors.forename: E
authors.initials: E
authors.lastname: Kriegova
authors.forename: K
authors.initials: K
authors.lastname: Indrak
authors.forename: M
authors.initials: M
authors.lastname: Petrek
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D018153:Czech Republic; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006086:Graft vs Host Disease / Q000235:genetics* / Q000276:immunology / Q000401:mortality; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000401:mortality; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics* / Q000276:immunology; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D014184:Transplantation, Homologous / Q000276:immunology*; D055815:Young Adult
chemical_list: D015850:Interleukin-6