Anti-angiogenic, anti-inflammatory and anti-nociceptive activities of vanillyl alcohol.
Vanillyl alcohol displayed a significant inhibition in the chick chorioallantoic membrane (CAM) angiogenesis. Vanillyl alcohol was also shown to contain anti-inflammatory activity using acetic acid-induced permeability and carrageenan-induced air pouch models in mice. Anti-nociceptive activity of vanillyl alcohol was also assessed using acetic acid-induced writhing test in mice. Taken together, vanillyl alcohol possesses anti-angiogenic, anti-inflammatory, and anti-nociceptive activities, which may be partly responsible for pharmacological efficacies of several folkloric medicines containing vanillyl alcohol.
Jung
Hyun-Joo
HJ
College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Korea.
Song
Yun Seon
YS
Lim
Chang-Jin
CJ
Park
Eun-Hee
EH
D019342:Acetic Acid / Q000494:pharmacology; D000700:Analgesics; D020533:Angiogenesis Inhibitors; D000818:Animals; D000893:Anti-Inflammatory Agents; D001592:Benzyl Alcohols / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects; D002351:Carrageenan; D002470:Cell Survival / Q000187:drug effects; D049033:Chorioallantoic Membrane / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009573:Nitrites / Q000378:metabolism; D013778:Tetrazolium Salts; D013844:Thiazoles
D000700:Analgesics; D020533:Angiogenesis Inhibitors; D000893:Anti-Inflammatory Agents; D001592:Benzyl Alcohols; D009573:Nitrites; D013778:Tetrazolium Salts; D013844:Thiazoles; D002351:Carrageenan; C022616:thiazolyl blue; D019342:Acetic Acid; C024078:vanillyl alcohol