Epstein-Barr virus renders the infected natural killer cell line, NKL resistant to doxorubicin-induced apoptosis.
We established two Epstein-Barr virus (EBV)-infected NKL sublines, which acquired stress resistant phenotype against DNA damage and starvation compared with EBV-negative NKL. EBV-rendered doxorubicin resistance at least partially through NF-kappaB activation and the resultant sustenance of antiapoptotic proteins including Bcl-X(L) and FLIP(L/S).
Isobe
Y
Y
Department of Hematology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan.
Sugimoto
K
K
Matsuura
I
I
Takada
K
K
Oshimi
K
K
D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology; D053446:CASP8 and FADD-Like Apoptosis Regulating Protein / Q000378:metabolism; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000494:pharmacology*; D019008:Drug Resistance, Neoplasm / Q000502:physiology*; D020031:Epstein-Barr Virus Infections / Q000235:genetics / Q000378:metabolism*; D005434:Flow Cytometry; D004854:Herpesvirus 4, Human; D006801:Humans; D015151:Immunoblotting; D007694:Killer Cells, Natural / Q000378:metabolism / Q000821:virology*; D016328:NF-kappa B / Q000378:metabolism; D051020:bcl-X Protein / Q000378:metabolism
D053446:CASP8 and FADD-Like Apoptosis Regulating Protein; D016328:NF-kappa B; D051020:bcl-X Protein; D004317:Doxorubicin