Evaluation of certain pharmaceuticals with hexa-amminecobalt(III) tricarbonatocobaltate(III)-I Determination of some N-substituted phenothiazine derivatives.
Hexa-amminecobalt(III) tricarbonatocobaltate(III) (HCTC) has been used for the determination of six N-substituted phenothiazine derivatives. The drugs in 10% v/v sulphuric acid medium were titrated with 5 x 10(-3)M HCTC with visual or spectrophotometric end-point detection. The stoichiometry of the reaction was assumed and a reaction mechanism suggested. The methods were applied to the analysis of dosage forms with results comparable to those given by the official methods.
Walash
M I
MI
Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura, Egypt.
Belal
F
F
Aly
F A
FA