title: Laryngeal true malignant mixed tumor.
abstract: BACKGROUND
  True malignant mixed tumor, also known as carcinosarcoma, is a salivary gland type malignant neoplasm, which is extremely rare, and only a few cases arising in the larynx have been previously reported.
  
  
  RESULTS
  We report a case of true malignant mixed tumor arising in the larynx of a 65-year-old woman successfully treated with surgery. Histologically, the neoplasm was composed of variably mixed, neoplastic glandular, spindle, and chondroid tissues. Immunohistochemical analyses showed a peculiar expression of myoepithelial markers such as p63 and calponin in the glandular epithelial component, whereas malignant spindle cell proliferation was immunoreactive for calponin and actin.
  
  
  CONCLUSIONS
  These results strengthen the hypothesis that these neoplasms may develop from a divergent differentiation of a totipotent, myoepithelial precursor cell. Despite the unfavorable prognosis that has always been described for these neoplasms, the patient is alive with no evidence of recurrences 5 years after surgery.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, University of Ferrara, 44100 Ferrara, Italy. fstomeo@libero.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Stomeo
authors.forename: Paolo Cossu
authors.initials: PC
authors.lastname: Rocca
authors.forename: Corrado
authors.initials: C
authors.lastname: Bozzo
authors.forename: Chiara
authors.initials: C
authors.lastname: Bianchini
authors.forename: Francesco
authors.initials: F
authors.lastname: Meloni
authors.forename: Antonio
authors.initials: A
authors.lastname: Pastore
mesh_terms: D000368:Aged; D002296:Carcinosarcoma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D018198:Mixed Tumor, Malignant / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery