Spectrophotometric determination of paracetamol with iodylbenzene.
Paracetamol (N-acetyl-4-aminophenol) has been determined spectrophotometrically by its oxidation with iodylbenzene in acetone to produce the yellow-orange N-acetyl-1,4-benzoquinoneimine, which attains maximum colour intensity within 1 min and absorbs maximally at 430 nm. The maximum molar absorptivity is 1.58 x 10(3) l.mole(-1).cm(-1). The method is simple and rapid and has been found to be unaffected by the presence of salicylamide, oxyphenbutazone, acetylsalicylic acid, dipyrone and a number of other excipients.
Verma
K K
KK
Department of Chemistry, R.D. University of Jabalpur, Jabalpur 482001, India.
Jain
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