title: [Two cases of anaplastic carcinoma of the pancreas in terms of the diversity of carcinoma cells (epithelial-mesenchymal transition; EMT)].
abstract: The first evaluated case was a 71-year-old man with melaena. A huge tumor mass was observed in the tale of the pancreas, which we diagnosed as pancreatic carcinoma. Pathological findings confirmed that it was anaplastic pancreas carcinoma (giant cell type). The second case was a 61-year-old woman with upper abdominal pain. Irregular tumors with scattered cysts were observed in the tale of the pancreas, which rapidly increased. Autopsy findings confirmed that it was anaplastic pancreas carcinoma (pleomorphic type). Both cases showed positive for epithelial marker and mesenchymal markers and decrease in stainability by E-cadherin staining, a result which suggested diversity of tumor cells in anaplastic pancreas carcinomas.
authors.affiliation: Department of Gastroenterology and Hepatology, Internal Medicine, St. Marianna University School of Medicine.
authors.forename: Masaru
authors.initials: M
authors.lastname: Okamoto
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kitajima
authors.forename: Ryuujirou
authors.initials: R
authors.lastname: Negishi
authors.forename: Tadateru
authors.initials: T
authors.lastname: Maehata
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Kouro
authors.forename: Shunichi
authors.initials: S
authors.lastname: Yamauchi
authors.forename: Hideaki
authors.initials: H
authors.lastname: Takahashi
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Katakura
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Abiko
authors.forename: Shinichi
authors.initials: S
authors.lastname: Nakaya
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Inaba
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Takano
authors.forename: Michihiro
authors.initials: M
authors.lastname: Suzuki
authors.forename: Fumio
authors.initials: F
authors.lastname: Itoh
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000368:Aged; D001344:Autopsy; D014408:Biomarkers, Tumor / Q000032:analysis; D015820:Cadherins / Q000032:analysis; D002277:Carcinoma / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D003952:Diagnostic Imaging; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008297:Male; D008551:Melena / Q000209:etiology; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000150:complications / Q000175:diagnosis / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D015820:Cadherins