title: [Recent advances in the detection of recombinant human erythropoiesis and its analogs in doping control].
abstract: Recombinant human erythropoietin (rhEPO) is one of hormone dopings. In the recent years, it has been always misused in endurance competition sports. It is extremely difficult to discriminate between the natural endogenous erythropoietin (EPO) and recombinant exogenous hormone because they have identical amino acid sequences, and EPO has a relatively short half-life and very low concentration in blood or urine. In this paper, the research progress on the analysis and detection of rhEPO and its analogs by direct and indirect methods are reviewed. Future direction and prospects of the detection of rhEPO in doping control are discussed based on the research of our group.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China. xyang@pku.edu.cn
authors.forename: Xia
authors.initials: X
authors.lastname: Yang
authors.forename: Nannan
authors.initials: N
authors.lastname: Pang
authors.forename: Yiping
authors.initials: Y
authors.lastname: Liao
authors.forename: Huwei
authors.initials: H
authors.lastname: Liu
mesh_terms: D004300:Doping in Sports / Q000379:methods*; D004920:Erythropoiesis; D004921:Erythropoietin / Q000031:analogs & derivatives* / Q000032:analysis* / Q000235:genetics; D006728:Hormones / Q000032:analysis / Q000737:chemistry / Q000235:genetics; D006801:Humans; D011994:Recombinant Proteins / Q000032:analysis* / Q000737:chemistry / Q000235:genetics; D015813:Substance Abuse Detection / Q000379:methods*
chemical_list: D006728:Hormones; D011994:Recombinant Proteins; D004921:Erythropoietin