title: A new method for creating electrophysiological maps for DBS surgery and their application to surgical guidance.
abstract: Electrophysiological maps based on a Gaussian kernel have been proposed as a means to visualize response to stimulation in deep brain stimulation (DBS) surgeries. However, the Gaussian model does not represent the underlying physiological phenomenon produced by stimulation. We propose a new method to create physiological maps, which relies on spherical shell kernels. We compare our new maps to those created with Gaussian kernels and show that, on simulated data, this new approach produces more realistic maps. Experiments we have performed with real patient data show that our new maps correlate well with the underlying anatomy. Finally, we present preliminary results on an ongoing study assessing the value of these maps as pre-operative planning and intra-operative guidance tools.
authors.affiliation: Dept. Of Electrical Eng. & Computer Science, Vanderbilt University, Nashville, TN, USA. sri.pallavaram@vanderbilt.edu
authors.forename: Srivatsan
authors.initials: S
authors.lastname: Pallavaram
authors.forename: Pierre-Francois
authors.initials: PF
authors.lastname: D'Haese
authors.forename: Chris
authors.initials: C
authors.lastname: Kao
authors.forename: Hong
authors.initials: H
authors.lastname: Yu
authors.forename: Michael
authors.initials: M
authors.lastname: Remple
authors.forename: Joseph
authors.initials: J
authors.lastname: Neimat
authors.forename: Peter
authors.initials: P
authors.lastname: Konrad
authors.forename: Benoit
authors.initials: B
authors.lastname: Dawant
mesh_terms: D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D003198:Computer Simulation; D046690:Deep Brain Stimulation / Q000295:instrumentation / Q000379:methods*; D004567:Electrodes, Implanted; D006801:Humans; D008959:Models, Neurological; D015233:Models, Statistical; D019919:Prosthesis Implantation / Q000379:methods*; D025321:Surgery, Computer-Assisted / Q000379:methods*