Apoptosis-related molecules in blood in multiple sclerosis.
A failure in apoptosis of lymphocytes may lead to harmful immunoreactivity in MS. We analyzed apoptosis-related molecules including TRAIL, sFas, sFasL and MIF in the blood of 117 MS patients and controls to answer whether these molecules may be used in the evaluation of disease activity and immunomodulatory effect of IFN-beta. Increased levels of sTRAIL, sFasL and MIF were found in sera of untreated patients with MS relapse indicating their association with MS disease activity. IFN-beta treated patients in remission had increased TRAIL mRNA, sTRAIL, sFaL and MIF that most likely reflect bioactivity of IFN-beta.
Rinta
Sanna
S
Neuroimmunology Unit, Department of Neurology, Finn-Medi 3, Biokatu 10, 33014 University of Tampere, Finland.
Kuusisto
Hanna
H
Raunio
Minna
M
Paalavuo
Raija
R
Levula
Mari
M
Lehtimäki
Terho
T
Elovaara
Irina
I
D000328:Adult; D017209:Apoptosis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D016899:Interferon-beta / Q000494:pharmacology / Q000627:therapeutic use; D019746:Intramolecular Oxidoreductases / Q000097:blood* / Q000235:genetics; D008263:Macrophage Migration-Inhibitory Factors / Q000097:blood* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000188:drug therapy / Q000473:pathology*; D012333:RNA, Messenger / Q000378:metabolism; D013223:Statistics as Topic; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000097:blood / Q000235:genetics / Q000378:metabolism; D048069:Tumor Necrosis Factors / Q000097:blood* / Q000235:genetics
D008263:Macrophage Migration-Inhibitory Factors; D012333:RNA, Messenger; D053221:TNF-Related Apoptosis-Inducing Ligand; C505653:TNFSF10 protein, human; D048069:Tumor Necrosis Factors; D016899:Interferon-beta; D019746:Intramolecular Oxidoreductases; C515598:MIF protein, human