title: Changes of nitric oxide synthase activity and free methylarginines contents in regenerating rat liver after partial hepatectomy.
abstract: In the present study, liver regeneration rate (%) was increased up to 70% 3 days after partial hepatectomy (PH). Nitric oxide synthase (NOS) activity in liver tissue as well as serum nitrite/nitrate content had no timed response, revealing no significant difference between shamoperated and partially hepatectomized rat liver. Contents of free methylarginines in liver tissue were increased biphasically in a time-dependent manner after PH. However, those in serum did not exhibit the same patterns as in liver. Taken together, the results suggest that N(G)-monomethyl-L-arginine (MMA) and N(G), N(G)-dimethylarginine (DMA) play a role in inhibiting nitric oxide (NO) synthesis in regenerating rat liver because the increase of their contents was synchronized with NOS expression.
authors.affiliation: Department of Biochemistry, College of Pharmacy, Sungkyunkwan University, 440-746, Suwon, Korea.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Lee
authors.forename: S W
authors.initials: SW
authors.lastname: Nam
authors.forename: D W
authors.initials: DW
authors.lastname: Seo
authors.forename: S H
authors.initials: SH
authors.lastname: Ahn
authors.forename: Y K
authors.initials: YK
authors.lastname: Ko
authors.forename: D S
authors.initials: DS
authors.lastname: Sung
authors.forename: J W
authors.initials: JW
authors.lastname: Han
authors.forename: S Y
authors.initials: SY
authors.lastname: Hong
authors.forename: H W
authors.initials: HW
authors.lastname: Lee