Rosai Dorfman disease--a rare entity report of two cases with nodal and extranodal involvement.
Rosai Dorfman Disease (RDD) also known as Sinus Histiocytosis with Massive Lymphadenopathy (SHML)is a very rare variety of reactive histiocytoses. It commonly involves cervical lymph nodes; although involvement of other lymph node regions, skin and other organ involvement can occur. It has a good prognosis so there is a need to differentiate it from other lympho proliferative disorders of poorer prognosis. We present two cases of this rare disorder illustrating its clinical spectrum; a 22 years old woman with involvement of submandibular lymph nodes, nasal septum and sub-glottic region and a 45 years old male with prominent skin involvement.
Jalil
Jawad
J
Department of Paediatrics, Combined Military Hospital, Bahawalpur.
Dar
Nasser Rashid
NR
Shafique
Mobeen
M
D000328:Adult; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006644:Histiocytes / Q000473:pathology; D015618:Histiocytosis, Sinus / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D055815:Young Adult
D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D008727:Methotrexate