title: Spectrophotometric determination of astemizole.
abstract: Four simple and sensitive spectrophotometric methods for the determination of astemizole (AZ) in pure samples and pharmaceutical formulations are described. They are based on the oxidation of astemizole with excess N-bormosuccinimide (NBS) and determination of the unconsumed NBS with, metol-sulphanilamide (method A, lambda(max): 520 nm) or celestine blue (method B, lambda(max): 540 nm); or by the reduction of Folin-ciocalteu reagent (method C, lambda(max): 720 nm); or by the formation of a chloroform-soluble, coloured ion-association complex between the drug and azocarmine G (AG) at pH 1.5 (method D, lambda(max); 540 nm). The results obtained are reproducible with a coefficient of variation of less than 1.0%.
authors.affiliation: Foods and Drugs Laboratories, School of Chemistry, Andhra University, Visakhapatnam 530 003, India.
authors.forename: C S
authors.initials: CS
authors.lastname: Sastry
authors.forename: P Y
authors.initials: PY
authors.lastname: Naidu