Disruption of learned timing in P/Q calcium channel mutants.
To optimize motor performance, both the amplitude and temporal properties of movements should be modifiable by motor learning. Here we report that the modification of movement timing is highly dependent on signaling through P/Q-type voltage-dependent calcium channels. Two lines of mutant mice heterozygous for P/Q-type voltage-dependent calcium channels exhibited impaired plasticity of eye movement timing, but relatively intact plasticity of movement amplitude during motor learning in the vestibulo-ocular reflex. The results thus demonstrate a distinction between the molecular signaling pathways regulating the timing versus amplitude of movements.
Katoh
Akira
A
Department of Neurobiology, Stanford University, Stanford, CA, USA.
Chapman
Peter J
PJ
Raymond
Jennifer L
JL
D000818:Animals; D020864:Calcium Channels, N-Type; D020865:Calcium Channels, P-Type / Q000235:genetics / Q000378:metabolism*; D020907:Calcium Channels, Q-Type / Q000235:genetics / Q000378:metabolism*; D005133:Eye Movements / Q000502:physiology*; D019416:Head Movements / Q000502:physiology; D007858:Learning / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009154:Mutation; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013997:Time Factors
D020864:Calcium Channels, N-Type; D020865:Calcium Channels, P-Type; D020907:Calcium Channels, Q-Type