title: A clinical assessment of direct electrochemical urate measurements.
abstract: The response characteristics of various carbon substrates towards the direct oxidative measurement of urate and other key purine biomarkers have been compared. A novel carbon fibre laminate assembly has been proposed as an alternative substrate for the preparation of disposable sensing strips. The fabrication method is generic and readily transferable to a number of sensor applications. Its performance in the determination of urate within biofluids (serum and plasma) has been critically assessed. An inter-laboratory pilot study demonstrated the bioanalytical efficacy of the approach with the responses validated through comparison with the standard colorimetric (uricase/peroxidase) assay.
authors.affiliation: Department of Chemistry, School of Biomedical and Natural Sciences, Nottingham Trent University, Nottingham, Notts NG11 8NS, UK.
authors.forename: Jodi S N
authors.initials: JS
authors.lastname: Dutt
authors.forename: Callum
authors.initials: C
authors.lastname: Livingstone
authors.forename: Marco F
authors.initials: MF
authors.lastname: Cardosi
authors.forename: Shelley J
authors.initials: SJ
authors.lastname: Wilkins
authors.forename: James
authors.initials: J
authors.lastname: Davis