Iodometric submicro determination of alpha-amino-alcohols by an amplification reaction.
New methods are described for the iodometric submicro determination of alpha-aminoalcohols possessing primary, secondary or tertiary amino-groups which involve 6-, 12-, and 18-fold amplification reactions, respectively. The methods are based on reaction of the alpha-amino-alcohols with an excess of potassium periodate in a slightly alkaline medium, masking of the unreacted periodate with molybdate at pH 3.2 and, after addition of iodide, iodometric determination of the equivalent amounts of iodate released. In addition to being simple and rapid, the methods are sufficiently selective and specific and also highly accurate, being particularly suitable for the analysis of submicro amounts (50-150 microg); the average recovery is 99.9%.
Besada
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Microanalytical Research Laboratory, National Research Centre, Dokki, Cairo, Egypt (A.R.E.).
Gawargious
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