title: Electrospun polyacrylonitrile nanofibrous biomaterials.
abstract: An N-halamine precursor, 3-(5'-methyl-5'-hydantoinyl)acetanilide (I), was synthesized in our laboratory and loaded onto electrospun polyacrylonitrile fiber to prepare nanosized biocidal materials, which could be rendered antimicrobial by exposure to household bleach. Differential scanning calorimetry was used to study the thermal properties of the nanofibers with and without the N-halamine precursor and its chlorinated derivative loaded. Scanning electron microscopy demonstrated that the ultrafine fibers formed with diameters from 250 to 600 nm. Chlorinated nanofibrous mats composed of the fibers were challenged with Staphylococcus aureus (ATCC 6538) and Escherichia coli O157:H7 (ATCC 43895); they showed promising inactivation efficacies against the two bacterial species within 5 minutes of contact. Potential uses of the antimicrobial fibers include filters for industrial water and air disinfection and protective clothing.
authors.affiliation: Department of Chemistry and Biochemistry, Auburn University, Auburn, AL 36849, USA.
authors.forename: Xuehong
authors.initials: X
authors.lastname: Ren
authors.forename: Akin
authors.initials: A
authors.lastname: Akdag
authors.forename: Changyun
authors.initials: C
authors.lastname: Zhu
authors.forename: Lei
authors.initials: L
authors.lastname: Kou
authors.forename: S D
authors.initials: SD
authors.lastname: Worley
authors.forename: T S
authors.initials: TS
authors.lastname: Huang
mesh_terms: D000083:Acetanilides / Q000737:chemistry* / Q000494:pharmacology*; D000180:Acrylic Resins / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001672:Biocompatible Materials / Q000737:chemistry*; D019453:Escherichia coli O157 / Q000187:drug effects; D006827:Hydantoins / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D049329:Nanostructures / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: C547389:3-(5-methyl-5-hydantoinyl)acetanilide; D000083:Acetanilides; D000180:Acrylic Resins; D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D006827:Hydantoins; C010504:polyacrylonitrile