Norlignan derivatives from Curculigo crassifolia and their DPPH radical scavenging activity.
A novel norlignan derivative, crassifogenin C (1), and a known compound, curcapital (2), were isolated from the ethanolic extract of the rhizomes of Curculigo crassifolia. Their structures were elucidated on the basis of spectroscopic evidence and comparisons with literature data. Curcapital (2) was isolated from this plant for the first time. The free radical scavenging activity of the isolated compounds along with crassifoside E (3) and crassifoside F (4), which were reported previously, was evaluated by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. All compounds showed strong radical scavenging activity. The primary structure-activity relationship is also discussed.
Wang
Kai-Jin
KJ
College of Life Sciences, Anhui University, Hefei 230039, PR China.
Li
Ning
N
D001205:Ascorbic Acid / Q000494:pharmacology; D001713:Biphenyl Compounds; D031408:Curculigo / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry*; D017705:Lignans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010851:Picrates / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D017705:Lignans; D010851:Picrates; C533536:crassifogenin c; C533537:curcapital; C004931:1,1-diphenyl-2-picrylhydrazyl; D001205:Ascorbic Acid