Angioedema after local trauma in a patient on angiotensin-converting enzyme inhibitor therapy.
Angioedema is a side effect that is often associated with the use of angiotensin-converting enzyme (ACE) inhibitor medications. These medications result in increased levels of circulating bradykinins. This case illustrates the result of a local traumatic event to the upper lip, presumably causing marked bradykinin release in a patient who was taking an ACE inhibitor. The local release of bradykinin from trauma, in addition to decreased bradykinin catabolism secondary to ACE inhibitor therapy, resulted in angioedema predominantly in the upper lip. The angioedema resolved with discontinuation of the ACE inhibitor.
Simmons
B Brent
BB
Section of Geriatric Medicine, Temple University, Philadelphia, PA 19140, USA. b.brent.simmons@tuhs.temple.edu
Folsom
Michelle A
MA
Bryden
Leslie A
LA
Studdiford
James S
JS
D000328:Adult; D000799:Angioedema / Q000139:chemically induced* / Q000175:diagnosis / Q000378:metabolism; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D001920:Bradykinin / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008046:Lip / Q000098:blood supply / Q000473:pathology*; D012307:Risk Factors; D014947:Wounds and Injuries / Q000150:complications* / Q000378:metabolism
D000806:Angiotensin-Converting Enzyme Inhibitors; D001920:Bradykinin