title: Efficient synthesis of N-2-aryl-1,2,3-triazole fluorophores via post-triazole arylation.
abstract: Efficient post-triazole regioselective N-2 arylation was developed from C-4, C-5 disubstituted-1,2,3-NH-triazoles. Three different approaches had been investigated, including S(N)Ar, Cu(I) catalyzed aryl amidation and Cu(II) mediated boronic acid coupling. The N-2-aryl triazoles were successfully synthesized with excellent yields. The structures were characterized by X-ray crystallography and some N-2-triazole products gave strong fluorescence with various emission controlled by the C-5 groups.
authors.affiliation: Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 200071, China.
authors.forename: Yuxiu
authors.initials: Y
authors.lastname: Liu
authors.forename: Wuming
authors.initials: W
authors.lastname: Yan
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Chen
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Petersen
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Shi
mesh_terms: D000577:Amides / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D017785:Photons; D013050:Spectrometry, Fluorescence; D013237:Stereoisomerism; D013379:Substrate Specificity; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000577:Amides; D014230:Triazoles; D003300:Copper