[Chemical constituents from Polygonum capitatum and their antioxidation activities in vitro].
OBJECTIVE
To study the chemical constituents from Polygonum capitatum and their antioxidation activties in vitro.


METHODS
Compounds were isolated and purified by silica, polyamide and Sephadex LH-20 column chromatography. Their structures were identified by physicochemical properties and spectral analyses. The isolated compounds were screened with three antioxidation models in vitro.


RESULTS
Ten compounds were isolated and identified as galic acid (1), protocatechuic acid (2), progallin A (3), nimbecetin (4), quercetin (5), quercitroside (6), tetracosylferulate (7), quercetin-3-O-beta-D-glucoside (8), beta-deucosterol and beta-sitosterol (10). Compounds 1-6 from this plant showed antioxidation activities.


CONCLUSIONS
Compound 3 and 7 are isolated from this genus for the first time, compound 2, 4 and 9 are isolated from this plant for the first time, the pharmacological activities of the pure compounds from this plant are also reported firstly.
Liu
Zhi-Jun
ZJ
Department of Complex Prescription of TCM, China Pharmceutical University, Nanjing 210038, China.
Qi
Jin
J
Zhu
Dan-Ni
DN
Yu
Bo-Yang
BY
D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005609:Free Radicals / Q000378:metabolism; D005707:Gallic Acid / Q000737:chemistry / Q000302:isolation & purification; D062385:Hydroxybenzoates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D028502:Polygonum / Q000737:chemistry*; D011794:Quercetin / Q000737:chemistry / Q000302:isolation & purification
D047309:Flavones; D016166:Free Radical Scavengers; D005609:Free Radicals; D062385:Hydroxybenzoates; D010636:Phenols; C009091:protocatechuic acid; D005707:Gallic Acid; D011794:Quercetin