title: Topical anti-inflammatory activity of dianemycin isolated fromStreptomyces sp. MT 2705-4.
abstract: In order to develop new anti-inflammatory agents having different action mechanisms compared with nonsteroidal and steroidal anti-inflammatory drugs, the culture broths of various actinomycetes isolated from soil were screened using anin vivo mouse ear edma assay and one strain (Streptomyces sp. MT 2705-4: KCTC 8651P) was selected. Activity-guided purification led to the isolation of a polyether compound, dianemycin. Topically, dianemycin showed a potent anti-inflammatory activity in mouse ear edema induced by croton-oil or arachidonic acid. ED(50) value of dianemycin was found to be 0.8 mg/ear compared to 0.4 mg/ear of prednisolone in croton-oil ear edema. However, dianemycin did not show the inhibitory activity in UV-erythema and delayed hypersensitivity reaction. These results indicate that dianemycin is a potential topical anti-inflammatory agent.
authors.affiliation: College of Pharmacy, Kangwon National University, 200-701, Chuncheon, Korea.
authors.forename: S J
authors.initials: SJ
authors.lastname: Lee
authors.forename: H P
authors.initials: HP
authors.lastname: Kim
authors.forename: B K
authors.initials: BK
authors.lastname: Park
authors.forename: S C
authors.initials: SC
authors.lastname: Ahn
authors.forename: H S
authors.initials: HS
authors.lastname: Lee
authors.forename: J S
authors.initials: JS
authors.lastname: Ahn