Accommodation and antibodies.
Accommodation refers to the condition in which an organ transplant functions normally by acquiring resistance to immune-mediated injury (especially), despite the presence of anti-transplant antibodies in the recipient. This status is associated with several modifications in the recipient as well as in the graft, such as previous depletion of anti-graft antibodies and their slow return once the graft is placed; expression of several protective genes in the graft; a Th2 immune response in the recipient; and inhibition of the membrane attack complex of complement.
Dehoux
Jean-Paul
JP
Laboratory of Experimental Surgery, Faculté de médecine, Université catholique de Louvain, Brussels, Belgium.
Gianello
Pierre
P
D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity / Q000235:genetics; D051017:Apoptosis Regulatory Proteins / Q000276:immunology; D003165:Complement System Proteins; D019610:Cytoprotection / Q000235:genetics / Q000276:immunology; D005786:Gene Expression Regulation; D006085:Graft Survival / Q000276:immunology; D006419:Heme Oxygenase (Decyclizing) / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D006801:Humans; D056724:Immunity, Humoral; D007518:Isoantibodies / Q000276:immunology*; D016377:Organ Transplantation; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D018418:Th2 Cells / Q000276:immunology*; D023001:Transplantation Tolerance / Q000276:immunology*
D051017:Apoptosis Regulatory Proteins; D007518:Isoantibodies; D019253:Proto-Oncogene Proteins c-bcl-2; D003165:Complement System Proteins; D006419:Heme Oxygenase (Decyclizing)