Effects of lanthanum on human lymphocytes viability and DNA strand break.
Lanthanum (La) is a rare-earth metal with applications in agriculture, industry, and medicine. Since lanthanides show a broad spectrum of applications there is an increased risk of contamination for humans. We examined the effects of lanthanum in Jurkat cells and human peripheral lymphocytes (HPL), and we found that it was cytotoxic and genotoxic on both cell lines. Additionally, HPL were more sensitive to La treatment than Jurkat cells and necrosis was the pathway by which La induced cytotoxicity. Vitamin E was able to diminish the DNA strand breaks induced suggesting that oxidative stress may be involved in the genotoxic process.
Paiva
Amanda V
AV
Radiobiology Laboratory, Institute of Radiation Protection and Dosimetry, Brazilian Nuclear Energy Commission (CNEN), SEMEX, Salvador Allende Avenue, s/no., Recreio dos Bandeirantes, Rio de Janeiro 22780-160, RJ, Brazil.
de Oliveira
Monica S
MS
Yunes
Samira N
SN
de Oliveira
Leonardo G
LG
Cabral-Neto
Januário B
JB
de Almeida
Carlos Eduardo B
CE
D002273:Carcinogens / Q000633:toxicity*; D002470:Cell Survival / Q000187:drug effects; D004249:DNA Damage / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004336:Drug Antagonism; D004338:Drug Combinations; D004785:Environmental Pollutants / Q000145:classification / Q000633:toxicity*; D006801:Humans; D019169:Jurkat Cells; D007811:Lanthanum / Q000145:classification / Q000633:toxicity*; D008214:Lymphocytes / Q000187:drug effects* / Q000473:pathology; D009153:Mutagens / Q000633:toxicity*; D009336:Necrosis / Q000139:chemically induced; D014810:Vitamin E / Q000494:pharmacology
D002273:Carcinogens; D004338:Drug Combinations; D004785:Environmental Pollutants; D009153:Mutagens; D014810:Vitamin E; C016534:lanthanide nitrate; D007811:Lanthanum