Ovarian cancer and late onset paraneoplastic cerebellar degeneration.
Paraneoplastic cerebellar syndrome (PCD) is a rare, neurological disorder that primarily emerges before the detection of malignancy. We present a case involving a 52-year-old woman who was diagnosed and treated for primary ovarian cancer in 2005. In 2007, the patient exhibited ataxia, dysarthria and peripheral neuropathy. Following neurological assessment and immunologic testing, the diagnosis of PCD was made. The disease typically precedes the detection of malignancy by a year or more and has been documented in only a few cases following the treatment for ovarian cancer.
Goldstein
Bram H
BH
Gynecologic Oncology Associates, Hoag Hospital Cancer Center, 351 Hospital Road, Suite 507, Newport Beach, CA 92663, USA. bram@gynoncology.com
Birk
Connie L
CL
Van Houten
Mark
M
Veve
Robert
R
Brown
John V
JV
Rettenmaier
Mark A
MA
Micha
John P
JP
D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology*; D000906:Antibodies / Q000097:blood / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000276:immunology*; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000473:pathology*; D020362:Paraneoplastic Cerebellar Degeneration / Q000276:immunology / Q000473:pathology*
D000906:Antibodies; C095184:CDR2 protein, human; D007074:Immunoglobulin G; D009419:Nerve Tissue Proteins