title: The trace amine associated receptor (TAAR6) gene is not associated with schizophrenia in the Irish Case-Control Study of Schizophrenia (ICCSS) sample.
abstract: To replicate previous association between TAAR6 and schizophrenia, including our own finding in the Irish Study of High Density Schizophrenia Families (ISHDSF) sample, we genotyped 12 single nucleotide polymorphisms (SNPs) in the Irish Case-Control Study of Schizophrenia (ICCSS) sample. Only rs9389020 provided nominal evidence for association (p<0.0228), which did not withstand the permutation testing (p<0.2196). The combined odds ratio from ISHDSF and ICCSS samples [OR (95%CI)=1.0564 (1.0078-1.1074); p=0.02], while nominally significant, did not survive correction for multiple testing. Here we demonstrate that TAAR6 is not associated with schizophrenia in the ICCSS sample.
authors.affiliation: Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 East Leigh Street, Biotech 1-110, Richmond VA 23298, USA. vivladimirov@vcu.edu
authors.forename: Vladimir I
authors.initials: VI
authors.lastname: Vladimirov
authors.forename: Brion S
authors.initials: BS
authors.lastname: Maher
authors.forename: Brandon
authors.initials: B
authors.lastname: Wormley
authors.forename: F Anthony
authors.initials: FA
authors.lastname: O'Neill
authors.forename: Dermot
authors.initials: D
authors.lastname: Walsh
authors.forename: Kenneth S
authors.initials: KS
authors.lastname: Kendler
authors.forename: Brien P
authors.initials: BP
authors.lastname: Riley
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D018797:Cell Cycle Proteins / Q000235:genetics*; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D005838:Genotype; D006239:Haplotypes; D006306:Health Surveys; D006801:Humans; D007494:Ireland; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009660:Northern Ireland; D009687:Nuclear Proteins / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011618:Psychotic Disorders / Q000175:diagnosis / Q000235:genetics*; D043562:Receptors, G-Protein-Coupled; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*; D000095383:Trace Amine-Associated Receptors
chemical_list: D018797:Cell Cycle Proteins; D005819:Genetic Markers; D009687:Nuclear Proteins; D043562:Receptors, G-Protein-Coupled; C493988:TAAR6 protein, human; D000095383:Trace Amine-Associated Receptors