title: Amperometric determination of acetylsalicylic acid in drugs by batch injection analysis at a copper electrode in alkaline solutions.
abstract: This paper describes the determination of acetylsalicylic acid (ASA) as salicylate (SA) in pharmaceutical formulations by using amperometric detection with copper electrodes in 0.10 mol l(-1) NaOH solution. Batch injection analysis (BIA) was explored for this application. The system exhibited sharp current response peaks, rapid washout and excellent repeatability. A large linear dynamic range from 1 to 1000 mumol l(-1) was obtained by using an injected volume of 100 mul, with a detection limit of 0.48 mumol l(-1). R.S.D. of 0.37% for 30 repetitive (1x10(-4) mol l(-1)) injections and sampling frequency of 60 h(-1) were achieved. The results obtained using this system for ASA determination in seven different drug samples compared well with those found by spectrophotometry (Trinder test).
authors.affiliation: Instituto de Quimica, Universidade de São Paulo, Avenida Prof. Lineu Prestes, 748 CEP 05599-970, São Paulo, SP, Brazil.
authors.forename: Maria
authors.initials: M
authors.lastname: do Socorro Maia Quintino
authors.forename: Dennys
authors.initials: D
authors.lastname: Corbo
authors.forename: Mauro
authors.initials: M
authors.lastname: Bertotti
authors.forename: Lúcio
authors.initials: L
authors.lastname: Angnes