title: Enantioseparation of 15 organic phosphonate esters on the cellulose tris(3,5-dimethylphenyl carbamate) chiral stationary phase by HPLC.
abstract: A series of 15 organic phosphonate esters enatiomers containing a carbon atom as a chiral center have been separated on the cellulose tris(3,5-dimethylphenyl carbamate) chiral stationary phase (CSP) in the normal phase by high performance liquid chromatography (HPLC). Both the capacity factor (k) and separation factor (alpha) of all solutes are presented. The influence of the substitutional group on the benzene ring attached to the chiral carbon atom and the steric hindrance of alkoxyl of the phosphonate ester on the chiral separation are discussed. Based on alpha and different structure parameters, good agreement between the predicted values and the experimental ones is obtained. The most characteristic parameter influencing the chromatographic separation is chosen from many structure parameters by linear regression method of QSAR software. The probable mechanism of the chiral recognition is proposed.
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University, Jinan, China. duwei@icm.sdu.edu.cn
authors.forename: Wei
authors.initials: W
authors.lastname: Du
authors.forename: Guosheng
authors.initials: G
authors.lastname: Yang
authors.forename: Xinqiang
authors.initials: X
authors.lastname: Wang
authors.forename: Shiling
authors.initials: S
authors.lastname: Yuan
authors.forename: Lan
authors.initials: L
authors.lastname: Zhou
authors.forename: Dong
authors.initials: D
authors.lastname: Xu
authors.forename: Chengpu
authors.initials: C
authors.lastname: Liu