The impact of O2 availability on human cancer.
During the past century it has been established that regions within solid tumours experience mild to severe O(2) deprivation owing to aberrant vascular function. These hypoxic regions are associated with altered cellular metabolism, as well as increased resistance to radiation and chemotherapy. As discussed in this Timeline, over the past decade work from many laboratories has elucidated the mechanisms by which hypoxia-inducible factors (HIFs) modulate tumour cell metabolism, angiogenesis, growth and metastasis. The central role played by intra-tumoural hypoxia and HIF in these processes has made them attractive therapeutic targets in the treatment of multiple human malignancies.
Bertout
Jessica A
JA
Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Patel
Shetal A
SA
Simon
M Celeste
MC
D000332:Aerobiosis; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000502:physiology*; D002455:Cell Division; D015687:Cell Hypoxia / Q000502:physiology*; D006019:Glycolysis; D006801:Humans; D023421:Models, Animal; D009336:Necrosis; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D010101:Oxygen Consumption
D051792:Basic Helix-Loop-Helix Proteins