title: Suppressive effects of triterpenoids on CINC-1 induction in interleukin-1beta-stimulated rat fibroblast NRK-49F cells.
abstract: CINC-1 is a member of chemokine family with chemotactic and activating properties to neutrophils. CINC-1 induction in IL-1beta-stimulated rat fibroblast NRK-49F cells was quantitated by a sensitive ELISA. CINC-1 production was increased up to 135 ng/ml from basal 2-6 ng/ml by stimulation with IL-1beta. Steroidal anti-inflammatory drugs including dexamethasone and prednisolone exhibited potent suppressive effects on IL-1beta-induced CINC-1 production. Among 39 kinds of natural triterpenoids tested, acacigenin B exhibited the highest suppressive effects with about 10 muM to be 50% of inhibition on the CINC-1 induction. The suppressive potency of acacigenin B on IL-1beta-induced CINC-1 production was about 10-fold less than that of the steroidal anti-inflammatory drugs.
authors.affiliation: College of Pharmacy, Chungbuk National University, 361-763, Cheongju, Korea.
authors.forename: J Y
authors.initials: JY
authors.lastname: Ha
authors.forename: K R
authors.initials: KR
authors.lastname: Min
authors.forename: S H
authors.initials: SH
authors.lastname: Kang
authors.forename: J S
authors.initials: JS
authors.lastname: Kim
authors.forename: G I
authors.initials: GI
authors.lastname: Lee
authors.forename: S S
authors.initials: SS
authors.lastname: Kang
authors.forename: Y
authors.initials: Y
authors.lastname: Kim