Amino-sugar modular ligands-useful cores for the formation of asymmetric copper 1,4-addition catalysts.
Modular phosphine ligands, synthesised rapidly from commercial N-acetylglucosamine, are very effective in copper(i)-catalysed 1,4-additions of ZnR(2) to linear aliphatic enones (87-95% ee).
De Roma
Antonella
A
Dipartimento di Chimica Paolo Corradini, Università di Napoli Federico II, Complesso Universitario di Monte S. Angelo, via Cintia, Naples, Italy.
Ruffo
Francesco
F
Woodward
Simon
S
D000117:Acetylglucosamine / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D008024:Ligands; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D013237:Stereoisomerism; D015032:Zinc / Q000737:chemistry
D007659:Ketones; D008024:Ligands; D009942:Organometallic Compounds; D003300:Copper; D015032:Zinc; D000117:Acetylglucosamine