Ion-selective electrode for salicylate assay in blood serum.
A salicylate-selective membrane electrode made with heptyl-4-trifluoroacetylbenzoate as a neutral carrier was successfully applied for the determination of salicylate in blood serum. This procedure is advantageous because the free concentration of the drug in serum can be determined without sample preparation. The free salicylate concentrations determined by the ion-selective electrode compared to those obtained by conventional colorimetry gave a linear correlation coefficient 0.997 in the salicylate concentration range 0.1-2.5 mM.
Katsu
T
T
Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama, Japan.
Mori
Y
Y