A clinical assessment of direct electrochemical urate measurements.
The response characteristics of various carbon substrates towards the direct oxidative measurement of urate and other key purine biomarkers have been compared. A novel carbon fibre laminate assembly has been proposed as an alternative substrate for the preparation of disposable sensing strips. The fabrication method is generic and readily transferable to a number of sensor applications. Its performance in the determination of urate within biofluids (serum and plasma) has been critically assessed. An inter-laboratory pilot study demonstrated the bioanalytical efficacy of the approach with the responses validated through comparison with the standard colorimetric (uricase/peroxidase) assay.
Dutt
Jodi S N
JS
Department of Chemistry, School of Biomedical and Natural Sciences, Nottingham Trent University, Nottingham, Notts NG11 8NS, UK.
Livingstone
Callum
C
Cardosi
Marco F
MF
Wilkins
Shelley J
SJ
Davis
James
J