Primary intracranial dural-based synovial sarcoma with an unusual SYT fluorescence in situ hybridization pattern.
The authors present the case of an elderly man with a primary dural-based intracranial synovial sarcoma. Histological and immunohistochemical profiles of the lesion were diagnostic for a synovial sarcoma, and molecular studies using fluorescence in situ hybridization were compatible with a synovial sarcoma. A wide array of spindle cell neoplasms has been described as originating in the dura. To the authors' knowledge, however, this is only the second primary dura-based intracranial synovial sarcoma ever reported, emphasizing the importance of a broad differential diagnosis when encountering spindle cell lesions of the meninges.
Horbinski
Craig
C
Department of Pathology, University of Pittsburgh, Pennsylvania, USA. horbinskicm@upmc.edu
Cieply
Kathleen
K
Bejjani
Ghassan K
GK
McFadden
Kathryn
K
D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D012097:Repressor Proteins / Q000378:metabolism*; D012509:Sarcoma / Q000175:diagnosis; D013584:Sarcoma, Synovial / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology*
D011518:Proto-Oncogene Proteins; D012097:Repressor Proteins; C093961:SS18 protein, human