The contributions of prefrontal cortex and executive control to deception: evidence from activation likelihood estimate meta-analyses.
Previous neuroimaging studies have implicated the prefrontal cortex (PFC) and nearby brain regions in deception. This is consistent with the hypothesis that lying involves the executive control system. To date, the nature of the contribution of different aspects of executive control to deception, however, remains unclear. In the present study, we utilized an activation likelihood estimate (ALE) method of meta-analysis to quantitatively identify brain regions that are consistently more active for deceptive responses relative to truthful responses across past studies. We then contrasted the results with additional ALE maps generated for 3 different aspects of executive control: working memory, inhibitory control, and task switching. Deception-related regions in dorsolateral PFC and posterior parietal cortex were selectively associated with working memory. Additional deception regions in ventrolateral PFC, anterior insula, and anterior cingulate cortex were associated with multiple aspects of executive control. In contrast, deception-related regions in bilateral inferior parietal lobule were not associated with any of the 3 executive control constructs. Our findings support the notion that executive control processes, particularly working memory, and their associated neural substrates play an integral role in deception. This work provides a foundation for future research on the neurocognitive basis of deception.
Christ
Shawn E
SE
Department of Psychological Sciences, University of Missouri, Columbia, MO 65203, USA. christse@missouri.edu
Van Essen
David C
DC
Watson
Jason M
JM
Brubaker
Lindsay E
LE
McDermott
Kathleen B
KB
D001931:Brain Mapping / Q000379:methods*; D008192:Deception; D005071:Evoked Potentials / Q000502:physiology*; D005246:Feedback / Q000502:physiology; D006801:Humans; D008014:Lie Detection; D016013:Likelihood Functions; D017397:Prefrontal Cortex / Q000502:physiology*