Structural investigation of a new organic antiseptic: Taurolidine A spectroscopic study of its stability and equilibria in various solvents.
(1)H and (13)C NMR investigations of aqueous solutions of Taurolidine and Tauroflex have been made to determine their stability. This study revealed two successive equilibria, leading particularly to Taurultam-methylol (in 15% proportion) from a 0.5% Taurolidine solution. The methylol derivative is supposed to be the component active against bacteria and their endotoxins.
Erb
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Laboratoires de Toxicologie et de Physique, Faculté de Pharmacie, Rue du Professeur Laguesse, 59045 Lille, France.
Febvay
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Imbenotte
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