title: Glucose oxidation and PQQ-dependent dehydrogenases in Gluconobacter oxydans.
abstract: Gluconobacter oxydans is famous for its rapid and incomplete oxidation of a wide range of sugars and sugar alcohols. The organism is known for its efficient oxidation of D-glucose to D-gluconate, which can be further oxidized to two different keto-D-gluconates, 2-keto-D-gluconate and 5-keto-D-gluconate, as well as 2,5-di-keto-D-gluconate. For this oxidation chain and for further oxidation reactions, G. oxydans possesses a high number of membrane-bound dehydrogenases. In this review, we focus on the dehydrogenases involved in D-glucose oxidation and the products formed during this process. As some of the involved dehydrogenases contain pyrroloquinoline quinone (PQQ) as a cofactor, also PQQ synthesis is reviewed. Finally, we will give an overview of further PQQ-dependent dehydrogenases and discuss their functions in G. oxydans ATCC 621H (DSM 2343).
authors.affiliation: Fachgebiet Technische Biochemie, Institut fur Biotechnologie der Technischen Universität Berlin, Berlin, Germany.
authors.forename: Tina
authors.initials: T
authors.lastname: Hölscher
authors.forename: Ute
authors.initials: U
authors.lastname: Schleyer
authors.forename: Marcel
authors.initials: M
authors.lastname: Merfort
authors.forename: Stephanie
authors.initials: S
authors.lastname: Bringer-Meyer
authors.forename: Helmut
authors.initials: H
authors.lastname: Görisch
authors.forename: Hermann
authors.initials: H
authors.lastname: Sahm
mesh_terms: D003067:Coenzymes / Q000378:metabolism; D020600:Gluconobacter oxydans / Q000201:enzymology* / Q000235:genetics; D005947:Glucose / Q000235:genetics / Q000378:metabolism*; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000378:metabolism; D045542:PQQ Cofactor / Q000235:genetics / Q000378:metabolism*
chemical_list: D003067:Coenzymes; D045542:PQQ Cofactor; D010088:Oxidoreductases; D005947:Glucose