title: Synthesis and anti-inflammatory and analgesic activities of phenoxyalkanoic acid derivatives.
abstract: The synthesis of phenoxyalkanoic acid derivatives and their anti-inflammatory and analgesic activities are described. Analysis of structure-activity relationships shows that in trichlorophenoxy derivatives anti-edematous potency is associated with the presence of 1-thiopropyl moiety and 2 or 4-aminopyridyl moiety at R' position contributes to the analgesic activity.
authors.affiliation: Natural Products Research Institute, Seoul National University, 28, Yeonkeun Dong Chongro-Ku, 110-460, Seoul, Korea.
authors.forename: K H
authors.initials: KH
authors.lastname: Shin
authors.forename: E B
authors.initials: EB
authors.lastname: Lee
authors.forename: S W
authors.initials: SW
authors.lastname: Park
authors.forename: K J
authors.initials: KJ
authors.lastname: Shin
authors.forename: D C
authors.initials: DC
authors.lastname: Kim
authors.forename: D J
authors.initials: DJ
authors.lastname: Kim