title: The utilization of copper(II) phosphate for the anodic stripping voltammetric assay of alendronate sodium, desferrioxamine mesylate and lisinopril.
abstract: A sensitive differential pulse anodic stripping voltammetric method is described for the determination of alendronate sodium, desferrioxamine mesylate and lisinopril. The procedure is based on the formation of labile drug-copper(II) complex when shaking with copper(II) phosphate suspension. The voltammetric peaks, which correspond to the reduction of the copper(II) moiety of the formed complexes are obtained at -153, -74 and -111 mV, respectively. The different experimental parameters have been carefully studied. The method has been fully validated. The limit of detection was as low as 8.6 ng ml(-1). The method has been applied successfully for the determination of the drugs in plasma and in their pharmaceutical preparations. The obtained results were compared statistically with those obtained from a published method, in case of AS, or the official USP methods, for the other two drugs.
authors.affiliation: Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt. omarazak@hotmail.com
authors.forename: O Abdel
authors.initials: OA
authors.lastname: Razak
authors.forename: S F
authors.initials: SF
authors.lastname: Belal
authors.forename: M M
authors.initials: MM
authors.lastname: Bedair
authors.forename: R S
authors.initials: RS
authors.lastname: Haggag