Severe vitamin B-12 deficiency in a child mimicking thrombotic thrombocytopenic purpura.
We report a case of severe vitamin B-12 deficiency in a child who had a clinical presentation of hemolysis and thrombocytopenia that suggested the diagnosis of thrombotic thrombocytopenic purpura (TTP) and was associated with decreased ADAMTS13 activity. In this report, we review vitamin B-12 deficiency in children, the relationship between ADAMTS13 activity and TTP and discuss other conditions associated with decreased ADAMTS13 activity.
Dimond
Andrea
A
Department of Hematology Oncology, Children's Hospital Oakland, Oakland, California 94609, USA. adimond@gmail.com
George
James N
JN
Hastings
Caroline
C
D000293:Adolescent; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D011697:Purpura, Thrombotic Thrombocytopenic / Q000175:diagnosis* / Q000473:pathology; D014806:Vitamin B 12 Deficiency / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology