title: High-grade urothelial carcinoma: comparison of SurePath liquid-based processing with cytospin processing.
abstract: There is limited literature available comparing SurePath (SP) with conventional cytospins (CS) for urine cytology specimens, especially urothelial carcinoma. In this study, urinary tract cytology cases of high-grade urothelial carcinoma were assessed on SP and CS slides. Also, the morphologic differences of high-grade urothelial carcinoma between SP and CS were evaluated on a total of 35 cases of high-grade urothelial carcinoma. SP showed that the tumor cells tend to present as three-dimensional groups and have a smaller cell size than CS. In terms of nuclear features, SP and CS were found to be comparable in morphologic assessment of the tumor cells, with CS providing a slightly better visualization.
authors.affiliation: Department of Pathology and Laboratory Medicine, Emory University Hospital, Atlanta, Georgia, USA.
authors.forename: David Y
authors.initials: DY
authors.lastname: Lu
authors.forename: Aziza
authors.initials: A
authors.lastname: Nassar
authors.forename: Momin T
authors.initials: MT
authors.lastname: Siddiqui
mesh_terms: D002277:Carcinoma / Q000175:diagnosis* / Q000473:pathology / Q000652:urine*; D002498:Centrifugation; D016591:Histocytological Preparation Techniques / Q000379:methods*; D006801:Humans; D009367:Neoplasm Staging; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000652:urine*