Adsorptive voltammetry of lipoic acid and lipoamide, based on use of a catalytic hydrogen wave.
The adsorptive voltammetry of lipoic acid and lipoamide was investigated with a hanging mercury drop electrode. These compounds produced a catalytic hydrogen wave at - 1.35 V in ammonia buffer solution containing cobalt(II), and the peak current increased with adsorptive accumulation at the electrode. Thus adsorptive voltammetry with the catalytic hydrogen wave could provide a sensitive method for determining trace amounts of lipoic acid and lipoamide. The calibration graphs for both compounds were linear over the range 2-10nM with accumulation for 5 min at -0.6 V, and the detection limit was ca. 0.5nM.
Tanaka
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Department of Chemistry, Faculty of Science, Hokkaido University, Nishi-8, Kita-10, Kita-ku, Sapporo-shi, Hokkaido, Japan.
Yoshida
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