title: Monitoring CP-93,393 reaction mixtures by flow-injection analysis-mass spectrometry.
abstract: CP-93,393 is a drug candidate at Pfizer. Flow-injection analysis-mass spectrometry (FIA-MS) was used to monitor reaction completion for CP-93,393 reaction mixtures. FIA-MS provides essentially instantaneous results, is relatively simple to operate, and is a universal system that can be used to monitor any reaction as long as the product has a molecular weight that differs from the molecular weights of the reactants. The mass spectrometer for these studies employed atmospheric pressure chemical ionization. Samples were introduced into the mass spectrometer with a flowing stream of solvent.
authors.affiliation: Pfizer Central Research, Groton, CT 06340, USA.
authors.forename: S T
authors.initials: ST
authors.lastname: Colgan
authors.forename: T R
authors.initials: TR
authors.lastname: Sharp
authors.forename: P D
authors.initials: PD
authors.lastname: Hammen
authors.forename: R H
authors.initials: RH
authors.lastname: Reed
authors.forename: G J
authors.initials: GJ
authors.lastname: Horan
authors.forename: P W
authors.initials: PW
authors.lastname: Gwiazda