Antioxidant enzyme activity and malondialdehyde concentration in the plasma and erythrocytes of patients with urticaria induced by nonsteroidal anti-inflammatory drugs.
BACKGROUND
It has been suggested that oxidative stress is a crucial event in some forms of urticaria.


OBJECTIVE
To evaluate the blood oxidant/antioxidant profile of patients suffering from urticaria induced by nonsteroidal anti-inflammatory drugs (NSAIDs).


METHODS
We measured the activity of the antioxidant enzymes copper-zinc superoxide dismutase (Cu/ZnSOD), glutathione peroxidase (GSH-Px), and catalase (CAT), and the levels of malondialdehyde (a marker of lipid peroxidation) in the plasma and erythrocytes of 12 females with NSAID-induced urticaria and in 19 healthy controls.


RESULTS
The enzyme activity in plasma (CuZn/SOD) and in erythrocytes (CuZn/SOD, GSH-Px, and CAT) did not differ significantly between urticaria patients and controls. Moreover, the levels of malondialdehyde in plasma and erythrocytes did not differ significantly between the 2 groups.


CONCLUSIONS
It seems that processes associated with urticaria induced by NSAIDs may not modify antioxidant enzyme activity and may not enhance lipid peroxidation in peripheral blood.
Kasperska-Zajac
A
A
Clinical Department of Internal Diseases, Allergology and Clinical Immunology, Medical University of Silesia, Katowice, Poland. kasperska@plusnet.pl
Brzoza
Z
Z
Rogala
B
B
Polaniak
R
R
Birkner
E
E
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects; D002374:Catalase / Q000378:metabolism*; D004342:Drug Hypersensitivity; D004789:Enzyme Activation / Q000276:immunology; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation / Q000276:immunology; D008315:Malondialdehyde / Q000378:metabolism*; D018384:Oxidative Stress / Q000276:immunology; D012882:Skin Tests; D013482:Superoxide Dismutase / Q000378:metabolism*; D014581:Urticaria / Q000097:blood* / Q000139:chemically induced / Q000201:enzymology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase