Increased oxidative stress in patients with amyotrophic lateral sclerosis/Parkinsonism-dementia complex in the Kii peninsula, Japan.
Amyotrophic lateral sclerosis and Parkinsonism-dementia complex of the Kii peninsula (Kii ALS/PDC) is an endemic and a tauopathy, which shows clinical symptoms of amyotrophy, parkinsonism, and dementia. The objective of this study was to report the role of oxidative stress on Kii ALS/PDC using biochemical analysis. Urinary 8-hydroxydeoxyguanosine (8-OHdG)/creatinine ratio was analyzed in 11 patients with Kii ALS/PDC and 8 normal controls. The mean level of urinary 8-OHdG/creatinine ratio of the patients with Kii ALS/PDC was significantly higher than that of control subjects. Oxidative stress may be implicated in pathogenesis of Kii ALS/PDC.
Morimoto
Satoru
S
Department of Neurology, Mie University School of Medicine, Tsu, Japan.
Kuzuhara
Shigeki
S
Kokubo
Yasumasa
Y
D000368:Aged; D000369:Aged, 80 and over; D000690:Amyotrophic Lateral Sclerosis / Q000453:epidemiology / Q000378:metabolism* / Q000652:urine; D003404:Creatinine / Q000627:therapeutic use; D019353:Endemic Diseases; D005260:Female; D006151:Guanosine / Q000031:analogs & derivatives / Q000652:urine; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D018384:Oxidative Stress; D020734:Parkinsonian Disorders / Q000453:epidemiology / Q000378:metabolism* / Q000652:urine; D012720:Severity of Illness Index; D024801:Tauopathies / Q000453:epidemiology / Q000378:metabolism* / Q000652:urine
D006151:Guanosine; C046215:8-hydroxyguanosine; D003404:Creatinine