CYP2A6 allele frequencies in an Iranian population.
BACKGROUND
Genetic polymorphism of CYP2A6 gene is a major causal factor in the large interindividual differences in nicotine metabolism. It may have an impact on smoking behavior and smoke-related cancer susceptibility. Until now, there are no reports of CYP2A6 allele frequencies in Iranian population.


METHODS
In the present study, we investigated the frequencies of CYP2A6 alleles in 250 male Iranians. CYP2A6*2, CYP2A6*4, CYP2A6*9, and CYP2A6*12 were determined by allele-specific polymerase chain reaction.


RESULTS
Frequencies of *2, *4, *9, and *12 alleles were 2.2%, 0.95%, 12.4%, and 1.34%, respectively.


CONCLUSIONS
These results showed that the distribution of CYP2A6 alleles in Iranian population was different from those reported previously for other ethnic groups. This highlights the importance of conducting further studies to investigate the implications on smoking dependence and cancer in Iranians.
Emamghoreishi
Masoumeh
M
Department of Pharmacology, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran. emamm@sums.ac.ir
Bokaee
Hamid-Reza
HR
Keshavarz
Mojtaba
M
Ghaderi
Abbas
A
Tyndale
Rachel F
RF
D000293:Adolescent; D000328:Adult; D001189:Aryl Hydrocarbon Hydroxylases / Q000097:blood / Q000235:genetics*; D001782:Blood Donors / Q000706:statistics & numerical data; D065637:Cytochrome P-450 CYP2A6; D005787:Gene Frequency; D005828:Genetics, Population / Q000706:statistics & numerical data*; D005838:Genotype; D006801:Humans; D007492:Iran; D008297:Male; D012907:Smoking / Q000097:blood / Q000235:genetics; D055815:Young Adult
D001189:Aryl Hydrocarbon Hydroxylases; C585710:CYP2A6 protein, human; D065637:Cytochrome P-450 CYP2A6