title: MR-less high dimensional spatial normalization of 11C PiB PET images on a population of elderly, mild cognitive impaired and Alzheimer disease patients.
abstract: Beta-amyloid (Abeta) plaques are one of the neuropathological hallmarks of Alzheimer's disease (AD) and can be quantified using the marker 11C PiB. As l1C PiB PET images have limited anatomical information, an Magnetic Resonance Image (MRI) is usually acquired to perform the spatial normalization needed for population analysis. We designed and evaluated a high dimensional spatial normalization approach that only uses the 11C PiB PET image. The non-rigid registration (NRR) is based on free form deformation (FFD) modelled using B-splines. To compensate for the limited anatomical information, the FFD is constrained to an allowable transform space using a model trained from MR registrations. Abeta deposition is dependent on disease staging, so a spatially normalized 11C PiB PET appearance model selects and refines the atlas. The approach was compared with MR NRR using data from healthy elderly, mild cognitive impaired and Alzheimer disease participants. Using segmentation propagation, an average Dice similarity coefficient of 0.64 and 0.73 was obtained for white and gray matter. The R-squared correlation between the uptake obtained in the frontal, parietal, occipital and temporal was 0.789, 0.843, 0.871 and 0.964. These are very promising results, considering the low resolution of 11C PiB PET images.
authors.affiliation: Australian e-Health Research Centre, CSIRO ICT Centre, Brisbane, Australia.
authors.forename: Jurgen
authors.initials: J
authors.lastname: Fripp
authors.forename: Pierrick
authors.initials: P
authors.lastname: Bourgeat
authors.forename: Parnesh
authors.initials: P
authors.lastname: Raniga
authors.forename: Oscar
authors.initials: O
authors.lastname: Acosta
authors.forename: Victor
authors.initials: V
authors.lastname: Villemagne
authors.forename: Gareth
authors.initials: G
authors.lastname: Jones
authors.forename: Graeme
authors.initials: G
authors.lastname: O'keefe
authors.forename: Christopher
authors.initials: C
authors.lastname: Rowe
authors.forename: Sébastien
authors.initials: S
authors.lastname: Ourselin
authors.forename: Olivier
authors.initials: O
authors.lastname: Salvado
mesh_terms: D000465:Algorithms; D000544:Alzheimer Disease / Q000175:diagnosis*; D000814:Aniline Compounds; D001185:Artificial Intelligence; D052160:Benzothiazoles; D001921:Brain / Q000000981:diagnostic imaging*; D002247:Carbon Isotopes; D003072:Cognition Disorders / Q000175:diagnosis*; D003198:Computer Simulation; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging; D008954:Models, Biological; D015233:Models, Statistical; D010363:Pattern Recognition, Automated / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013844:Thiazoles
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000814:Aniline Compounds; D052160:Benzothiazoles; D002247:Carbon Isotopes; D019275:Radiopharmaceuticals; D013844:Thiazoles