title: Harmonic motion detection in a vibrating scattering medium.
abstract: Elasticity imaging is an emerging medical imaging modality that seeks to map the spatial distribution of tissue stiffness. Ultrasound radiation force excitation and motion tracking using pulse-echo ultrasound have been used in numerous methods. Dynamic radiation force is used in vibrometry to cause an object or tissue to vibrate, and the vibration amplitude and phase can be measured with exceptional accuracy. This paper presents a model that simulates harmonic motion detection in a vibrating scattering medium incorporating 3-D beam shapes for radiation force excitation and motion tracking. A parameterized analysis using this model provides a platform to optimize motion detection for vibrometry applications in tissue. An experimental method that produces a multifrequency radiation force is also presented. Experimental harmonic motion detection of simultaneous multifrequency vibration is demonstrated using a single transducer. This method can accurately detect motion with displacement amplitude as low as 100 to 200 nm in bovine muscle. Vibration phase can be measured within 10 degrees or less. The experimental results validate the conclusions observed from the model and show multifrequency vibration induction and measurements can be performed simultaneously.
authors.affiliation: Department of Physiology and Biomedical Engineering, Ultrasound Research Laboratory, Mayo Clinic College of Medicine, Rochester, MN, USA. urban.matthew@mayo.edu
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Urban
authors.forename: Shigao
authors.initials: S
authors.lastname: Chen
authors.forename: James
authors.initials: J
authors.lastname: Greenleaf
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D054459:Elasticity Imaging Techniques / Q000379:methods*; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008954:Models, Biological; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D012680:Sensitivity and Specificity; D014732:Vibration