Determination of chloramphenicol by coupling a continuous reduction system to an atomic-absorption spectrometer.
A simple method for the determination of chloramphenicol in pure powders, capsules, tablets, oral suspensions and eye ointments, based on its reduction to the amino derivative by a cadmium or zinc column, is reported. Chloramphenicol can be determined in the range 2-30 microg/ml, with a relative standard deviation of 1.5% and a sampling frequency of 150/hr. The proposed method has greater simplicity, sensitivity and rapidity than the previously reported batch method.
Montero
R
R
Department of Analytical Chemistry, Faculty of Sciences, University of Córdoba, 14004 Córdoba, Spain.
Gallego
M
M
Valcarcel
M
M