title: Autonomic nervous function and arrhythmias in patients with acute viral myocarditis during a 6-month follow-up period.
abstract: OBJECTIVE
  It was our aim to study the outcome of autonomic nervous function (ANF), heart rate variability (HRV) and arrhythmias in patients with acute viral myocarditis in a 6-month follow-up period after the diagnosis.
  
  
  METHODS
  ANF was measured in patients with acute viral myocarditis 1, 3 and 6 months after the disease was diagnosed. HRV and arrhythmias were monitored by 24-hour electrocardiogram during the follow-up examination.
  
  
  RESULTS
  Ninety-six patients with acute viral myocarditis were enrolled in this study; 58% showed abnormal ANF tests, and the incidence was reduced to 17% after 6 months (p < 0.01). Time and frequency domain analyses of HRV were significantly reduced in the early stage of the disease and recovered after 6 months (p < 0.05). The incidence of arrhythmias in patients with abnormal ANF was significantly higher than in patients with normal ANF (p < 0.05). The incidence of arrhythmias in patients with abnormal ANF at 6 months was significantly lower than that at the first month (p < 0.05).
  
  
  CONCLUSIONS
  There is a significant impairment of ANF and a higher incidence of arrhythmias in the early stage of acute myocarditis. ANF and HRV abnormalities are significantly improved, and the incidence of arrhythmia is significantly reduced after 6 months in patients with acute myocarditis.
authors.affiliation: Department of Cardiology, Heart Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Xiuren
authors.initials: X
authors.lastname: Gao
authors.forename: Longyun
authors.initials: L
authors.lastname: Peng
authors.forename: Qunying
authors.initials: Q
authors.lastname: Zeng
authors.forename: Zhong-Kai
authors.initials: ZK
authors.lastname: Wu
mesh_terms: D000328:Adult; D001145:Arrhythmias, Cardiac / Q000209:etiology*; D001341:Autonomic Nervous System / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D006339:Heart Rate; D006801:Humans; D008297:Male; D009205:Myocarditis / Q000150:complications / Q000503:physiopathology* / Q000821:virology; D014777:Virus Diseases / Q000150:complications / Q000503:physiopathology*; D055815:Young Adult