title: Synthesis of substituted cinnamoyl-tyramine derivatives and their platelet anti-aggregatory activities.
abstract: Substituted cinnamoyl-tyramine derivatives were synthesized by DCC-coupling of substituted cinnamic acid with tyramine or tyramine methyl-1-ether to evaluate PAF-receptor binding antagonistic activities and inhibitory activities on PAF-induced platelet aggregation with interest on structure-activity relations. The results show that 3,4-dimethoxy-cinnamoyl tyramine-amide or its methyl ether have significant PAF-receptor binding antagonistic activity and platelet anti-aggregatory activities.
authors.affiliation: Il-Yang Central Research Institute, Hagal 182-4, Kiheung, Yongin, 449-900, Kyungki, Korea.
authors.forename: N T
authors.initials: NT
authors.lastname: Woo
authors.forename: S Y
authors.initials: SY
authors.lastname: Jin
authors.forename: D J
authors.initials: DJ
authors.lastname: Cho
authors.forename: N S
authors.initials: NS
authors.lastname: Kim
authors.forename: E H
authors.initials: EH
authors.lastname: Bae
authors.forename: D
authors.initials: D
authors.lastname: Han
authors.forename: B H
authors.initials: BH
authors.lastname: Han
authors.forename: Y H
authors.initials: YH
authors.lastname: Kang