title: Engineered polymers for advanced drug delivery.
abstract: Engineered polymers have been utilized for developing advanced drug delivery systems. The development of such polymers has caused advances in polymer chemistry, which, in turn, has resulted in smart polymers that can respond to changes in environmental condition such as temperature, pH, and biomolecules. The responses vary widely from swelling/deswelling to degradation. Drug-polymer conjugates and drug-containing nano/micro-particles have been used for drug targeting. Engineered polymers and polymeric systems have also been used in new areas, such as molecular imaging as well as in nanotechnology. This review examines the engineered polymers that have been used as traditional drug delivery systems and as more recent applications in nanotechnology.
authors.affiliation: Department of Pharmaceutics and Biomedical Engineering, Purdue University, West Lafayette, IN 47907-2032, USA.
authors.forename: Sungwon
authors.initials: S
authors.lastname: Kim
authors.forename: Jong-Ho
authors.initials: JH
authors.lastname: Kim
authors.forename: Oju
authors.initials: O
authors.lastname: Jeon
authors.forename: Ick Chan
authors.initials: IC
authors.lastname: Kwon
authors.forename: Kinam
authors.initials: K
authors.lastname: Park
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008863:Microspheres; D053758:Nanoparticles / Q000008:administration & dosage; D036103:Nanotechnology; D011108:Polymers / Q000737:chemistry*; D013696:Temperature
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011108:Polymers