title: Effect of acupuncture on the brain in children with spastic cerebral palsy using functional neuroimaging (FMRI).
abstract: We study the effect of acupuncture on brain activation patterns in children with cerebral palsy using functional magnetic resonance imaging (fMRI). fMRI of the whole brain was performed in 11 children with cerebral palsy and 10 healthy children during stimulation of a common acupoint in Traditional Medicine [Liv3 (Taichong)] on the left foot. We use both twisting and nontwisting methods with a blocked paradigm on a 2.0 Tesla MRI scanner. Functional data were analyzed by using Statistical Parametric Mapping software (SPM 99). Both signal increase and decrease in various regions of the brain were found in both groups of children. However, the pattern was different for the 2 groups, especially with decreases in signal regions. We suggest that the observed differences between children with cerebral palsy and healthy children with the stimulation of acupoint Liv3 might be due to blockage of the liver meridian in children with cerebral palsy.
authors.affiliation: Department of Neurology, Beijing Children's Hospital, The Capital Medical University, Beijing, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Wu
authors.forename: Zhen
authors.initials: Z
authors.lastname: Jin
authors.forename: Ke
authors.initials: K
authors.lastname: Li
authors.forename: Zhong-Li
authors.initials: ZL
authors.lastname: Lu
authors.forename: Virginia
authors.initials: V
authors.lastname: Wong
authors.forename: Tong-Li
authors.initials: TL
authors.lastname: Han
authors.forename: Hua
authors.initials: H
authors.lastname: Zheng
authors.forename: Opher
authors.initials: O
authors.lastname: Caspi
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.forename: Ya-Wei
authors.initials: YW
authors.lastname: Zeng
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Zou
mesh_terms: D026881:Acupuncture / Q000379:methods*; D001921:Brain / Q000098:blood supply* / Q000473:pathology / Q000503:physiopathology; D001931:Brain Mapping; D002547:Cerebral Palsy / Q000473:pathology* / Q000628:therapy*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D010100:Oxygen / Q000097:blood
chemical_list: D010100:Oxygen