title: Prevention of urinary tract infection in six spinal cord-injured pregnant women who gave birth to seven children under a weekly oral cyclic antibiotic program.
abstract: BACKGROUND
  Pregnancies in spinal cord-injured (SCI) patients present unique clinical challenges. Because of the neurogenic bladder and the use of intermittent catheterization, chronic bacteriuria and recurrent urinary tract infection (UTI) is common. During pregnancy the prevalence of UTI increases dramatically. Recurrent UTI requires multiple courses of antibiotics and increases the risks of abortion, prematurity, and low birth weight. A weekly oral cyclic antibiotic (WOCA) program was recently described for the prevention of UTI in SCI patients.
  
  
  OBJECTIVE
  To test the impact of WOCA in six SCI pregnant women (four paraplegic, two tetraplegic).
  
  
  METHODS
  This was a prospective observational study. WOCA consists of the alternate administration of one of two antibiotics once per week.
  
  
  RESULTS
  We observed a significant reduction of UTI (6 UTI/patient/year before pregnancy to 0.4 during pregnancy and under WOCA; p<0.001) and no obstetric complications. Infant outcomes were good.
  
  
  CONCLUSIONS
  The WOCA regimen could be useful for UTI prophylaxis in SCI pregnant women.
authors.affiliation: INSERM U657, PhEMI, Institut Pasteur, Paris, France. jerome.salomon@rpc.aphp.fr
authors.forename: Jérôme
authors.initials: J
authors.lastname: Salomon
authors.forename: Alexis
authors.initials: A
authors.lastname: Schnitzler
authors.forename: Yves
authors.initials: Y
authors.lastname: Ville
authors.forename: Isabelle
authors.initials: I
authors.lastname: Laffont
authors.forename: Christian
authors.initials: C
authors.lastname: Perronne
authors.forename: Pierre
authors.initials: P
authors.lastname: Denys
authors.forename: Louis
authors.initials: L
authors.lastname: Bernard
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D019072:Antibiotic Prophylaxis / Q000379:methods*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology* / Q000652:urine; D011446:Prospective Studies; D013119:Spinal Cord Injuries / Q000150:complications*; D047929:Term Birth; D014552:Urinary Tract Infections / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents