Allene-alkyne cross-coupling for stereoselective synthesis of substituted 1,4-dienes and cross-conjugated trienes.
Titanium-mediated cross-coupling of allenic alcohols with alkynes has been investigated. Divergent reaction pathways were discovered that provide either stereodefined 1,4-dienes or substituted cross-conjugated trienes. In short, allene substitution plays a critical role in the determination of reaction pathway.
Shimp
Heidi L
HL
Department of Chemistry, Yale Univeristy, New Haven, Connecticut 06520-8107.
Hare
Alissa
A
McLaughlin
Martin
M
Micalizio
Glenn C
GC