title: Antibody immobilization within glass microstructured fibers: a route to sensitive and selective biosensors.
abstract: Glass microstructured optical fibers have been rendered biologically active for the first time via the immobilization of antibodies within the holes in the fiber cross-section. This has been done by introducing coating layers to the internal surfaces of soft glass fibers. The detection of proteins that bind to these antibodies has been demonstrated experimentally within this system via the use of fluorescence labeling. The approach combines the sensitivity resulting from the long interaction lengths of filled fibers with the selectivity provided by the use of antibodies.
authors.affiliation: Centre of Expertise in Photonics, School of Chemistry & Physics, University of Adelaide, Adelaide, SA, Australia. yinlan.ruan@adelaide.edu.au
authors.forename: Yinlan
authors.initials: Y
authors.lastname: Ruan
authors.forename: Tze Cheung
authors.initials: TC
authors.lastname: Foo
authors.forename: Stephen
authors.initials: S
authors.lastname: Warren-Smith
authors.forename: Peter
authors.initials: P
authors.lastname: Hoffmann
authors.forename: Roger C
authors.initials: RC
authors.lastname: Moore
authors.forename: Heike
authors.initials: H
authors.lastname: Ebendorff-Heidepriem
authors.forename: Tanya M
authors.initials: TM
authors.lastname: Monro
mesh_terms: D000906:Antibodies / Q000378:metabolism*; D000936:Antigen-Antibody Complex; D015374:Biosensing Techniques; D005453:Fluorescence; D005898:Glass / Q000737:chemistry*; D012996:Solutions
chemical_list: D000906:Antibodies; D000936:Antigen-Antibody Complex; D012996:Solutions; C009753:fiberglass