title: A novel explicit 2D+t cyclic shape model applied to echocardiography.
abstract: In this paper, we propose a novel explicit 2D+t cyclic shape model that extends the Point Distribution Model (PDM) to shapes like myocardial contours with cyclic dynamics. We also propose an extension to Procrustes alignment that removes pose and subject size variability while maintaining dynamic effects. Our model draws on ideas from Principal Component Analysis (PCA), Multidimensional Scaling (MDS) and Kernel PCA (KPCA) and solves 3 shortcomings of previous implicit models: (1) cardiac cycles in the data set do not each need to have the same number of frames, (2) the required number of subjects for statistically significant results is substantially reduced and (3) the displacement of contour points incorporates time as an explicit variable. We illustrate our method by computing models of the myocardium in the 4 principal planes of 2D+t echocardiography data.
authors.affiliation: Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, UK. rcasero@robots.ox.ac.uk
authors.forename: Ramón
authors.initials: R
authors.lastname: Casero
authors.forename: J Alison
authors.initials: JA
authors.lastname: Noble
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D003198:Computer Simulation; D004452:Echocardiography / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008954:Models, Biological; D015233:Models, Statistical; D010363:Pattern Recognition, Automated / Q000379:methods*; D025341:Principal Component Analysis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity