Determination of ascorbic acid in pharmaceutical preparations by near infrared reflectance spectroscopy.
We developed a method for determination of ascorbic acid in pharmaceutical preparations containing various excipients by using near infrared diffuse reflectance spectroscopy and two different calibration methods, viz. stepwise multiple linear regression (SMLR) and partial least-squares (PLS) regression, which provided comparable results and resulted in prediction errors of 1-2%. However, the PLS method provided somewhat better results with the more complex samples.
Blanco
M
M
Departamento de Química, Unidad de Química Analítica, Universidad Autónoma de Barcelona, E-08193 Bellaterra, Barcelona, Spain.
Coello
J
J
Iturriaga
H
H
Maspoch
S
S
de la Pezuela
C
C