[Effect of anti-influenza virus H3N2 of Hypericum japonicum in vivo].
OBJECTIVE
To investigate anti-influenza virus H3N2 effect of Hypericum japonicum in vivo.


METHODS
The influences on lung index and death rate were observed in the mice infected with virus H3N2 from intranasal.


RESULTS
Experiments in vivo showed that Hypericum japonicum at the concentration of 10 g/kg x d for the intranasal treatment markedly inhibited the lung consolidation of mice pneumonia caused by the infection of influenza virus H3N2 and prolonged the survival time .


CONCLUSIONS
Hypericum japonicum may be effective on treating influenza.
Liu
Ni
N
Tropical Medicine Institute Guangzhou University of Chinese Medicine, Guangzhou 51043, China.
Hu
Xi-Liu
XL
Meng
Yi-Rong
YR
Zhu
Yu-Tong
YT
Huang
Bi-Song
BS
Lin
Pei-Zheng
PZ
D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D020902:Hypericum / Q000737:chemistry*; D053122:Influenza A Virus, H3N2 Subtype / Q000187:drug effects*; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000188:drug therapy* / Q000473:pathology / Q000821:virology; D010946:Plants, Medicinal / Q000737:chemistry; D011024:Pneumonia, Viral / Q000473:pathology; D011897:Random Allocation; D012254:Ribavirin / Q000008:administration & dosage / Q000494:pharmacology
D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D012254:Ribavirin