Is overcoming hormone resistance in breast cancer possible?
The administration of hormones plays a major role in the treatment of hormone receptor-expressing breast cancers (BCs), both in the adjuvant setting as well as in advanced disease. Hormone-responsive tumors almost uniformly develop resistance, either independently or as a result of exposure to hormones. Overcoming this phenomenon constitutes a perpetual challenge to researchers and clinical oncologists. Understanding the mechanisms leading to hormone resistance is crucial to its inhibition or, at least, its delayed onset. This manuscript provides a brief review of this topic.
Orphanos
G
G
Department of Oncology, Nicosia General Hospital, Nicosia, Cyprus. georgeorphanosvp@hotmail.com
Kakoullou
N
N
Ardavanis
A
A
D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000517:prevention & control*; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D009376:Neoplasms, Hormone-Dependent / Q000517:prevention & control*
D018931:Antineoplastic Agents, Hormonal