A tensor-based morphometry study of genetic influences on brain structure using a new fluid registration method.
We incorporated a new Riemannian fluid registration algorithm into a general MRI analysis method called tensor-based morphometry to map the heritability of brain morphology in MR images from 23 monozygotic and 23 dizygotic twin pairs. All 92 3D scans were fluidly registered to a common template. Voxelwise Jacobian determinants were computed from the deformation fields to assess local volumetric differences across subjects. Heritability maps were computed from the intraclass correlations and their significance was assessed using voxelwise permutation tests. Lobar volume heritability was also studied using the ACE genetic model. The performance of this Riemannian algorithm was compared to a more standard fluid registration algorithm: 3D maps from both registration techniques displayed similar heritability patterns throughout the brain. Power improvements were quantified by comparing the cumulative distribution functions of the p-values generated from both competing methods. The Riemannian algorithm outperformed the standard fluid registration.
Brun
Caroline
C
Laboratory of Neuro Imaging, UCLA, Los Angeles, CA 90095, USA.
Leporé
Natasha
N
Pennec
Xavier
X
Chou
Yi-Yu
YY
Lee
Agatha D
AD
Barysheva
Marina
M
de Zubicaray
Grieg
G
Meredith
Matthew
M
McMahon
Katie
K
Wright
Margaret J
MJ
Toga
Arthur W
AW
Thompson
Paul M
PM
D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology* / Q000502:physiology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods; D008297:Male; D010363:Pattern Recognition, Automated / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique; D014429:Twins, Dizygotic / Q000235:genetics*; D014430:Twins, Monozygotic / Q000235:genetics*; D055815:Young Adult