DNA-mediated electrochemistry.
The base pair stack of DNA has been demonstrated as a medium for long-range charge transport chemistry both in solution and at DNA-modified surfaces. This chemistry is exquisitely sensitive to structural perturbations in the base pair stack as occur with lesions, single base mismatches, and protein binding. We have exploited this sensitivity for the development of reliable electrochemical assays based on DNA charge transport at self-assembled DNA monolayers. Here, we discuss the characteristic features, applications, and advantages of DNA-mediated electrochemistry.
Gorodetsky
Alon A
AA
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.
Buzzeo
Marisa C
MC
Barton
Jacqueline K
JK
D000818:Animals; D004247:DNA / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D004563:Electrochemistry / Q000379:methods*; D008024:Ligands; D009693:Nucleic Acid Hybridization; D011485:Protein Binding; D011506:Proteins / Q000032:analysis / Q000378:metabolism
D008024:Ligands; D011506:Proteins; D004247:DNA