Local Ca2+ influx through CRAC channels activates temporally and spatially distinct cellular responses.
Ca(2+) entry through store-operated Ca(2+) release-activated Ca(2+) (CRAC) channels controls a disparate array of key cellular responses. In this review, recent work will be described that shows local Ca(2+) influx through CRAC channels has important spatial and temporal consequences on cell function. A localized Ca(2+) rise below the plasma membrane activates, within tens of seconds, catabolic enzymes resulting in the generation of the intracellular messenger arachidonic acid and the paracrine pro-inflammatory molecule LTC(4). In addition, local Ca(2+) entry can activate gene expression, which develops over tens of minutes. Local Ca(2+) influx through CRAC channels therefore has far-reaching consequences on intra- and intercellular communication.
Parekh
A B
AB
Department of Physiology, Anatomy and Genetics, Oxford University, Oxford, UK. anant.parekh@dpag.ox.ac.uk
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism*; D002462:Cell Membrane; D008407:Mast Cells / Q000502:physiology*; D013997:Time Factors
D015220:Calcium Channels; D002118:Calcium