title: Trace measurements of colchicine by adsorptive stripping voltammetry.
abstract: A highly sensitive voltammetric method for trace measurements of the alkaloid colchicine is described. The method is based on the controlled adsorptive accumulation of the drug at the hanging mercury drop electrode, followed by voltammetric determination of the surface species. The adsorptive stripping response is evaluated with respect to preconcentration time and potential, solution pH, voltammetric waveform and other variables. With a 10-min preconcentration, a detection limit of 1.3 x 10(-10)M is obtained. The relative standard deviation (at the 1 x 10(-7)M level) is 1.1%. Applicability to urine analysis is illustrated.
authors.affiliation: Department of Chemistry, New Mexico State University, Las Cruces, NM 88003, U.S.A.
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: M
authors.initials: M
authors.lastname: Ozsoz