Genome-widely significant evidence of linkage of schizophrenia to chromosomes 2p24.3 and 6q27 in an SNP-Based analysis of Korean families.
The present study reports the results of a genome-wide SNP linkage scan for schizophrenia in the Korean population. Fifty-six multiplex schizophrenia families were analyzed. Clinical evaluations on all subjects were consistently performed by raters in a single research team. Multipoint non-parametric linkage analysis was performed, and empirical simulations were generated to determine genome-wide significance. The authors found genome-widely significant evidence of linkage for schizophrenia to chromosomes 2p24.3 (NPL Z = 3.18) and 6q27 (NPL Z = 2.90). Six other chromosomal regions, that is, 3q24, 13q12.3, 18q22.3, 20p12.2, 4p14, and 1p36.12, yielded NPL Z scores of above 2.0 for either broad or narrow phenotype classes. Although linkage to these loci has not received prominent attention in studies on Caucasian families, multiple overlaps were observed between our loci (on 2p, 3q, and 13q) and linkage peaks generated from extended families in various isolated populations. Fine mappings and the detection of candidate genes within these regions are warranted.
Hong
Kyung Sue
KS
Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Kangnam-Gu, Seoul, South Korea.
Won
Hong-Hee
HH
Cho
Eun-Young
EY
Jeun
Hyun Ok
HO
Cho
Sang-Seon
SS
Lee
Yu-Sang
YS
Park
Dong Yeon
DY
Jang
Yong Lee
YL
Choi
Kyeong-Sook
KS
Lee
Dongsoo
D
Kim
Min-Ji
MJ
Kim
Seonwoo
S
Han
Wou Sang
WS
Kim
Jong-Won
JW
D002874:Chromosome Mapping / Q000379:methods; D002889:Chromosomes, Human, Pair 2; D002896:Chromosomes, Human, Pair 6; D004252:DNA Mutational Analysis / Q000379:methods; D005190:Family; D005787:Gene Frequency; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D007723:Korea; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*