Determination of aminocresol isomers by high-speed liquid chromatography.
Aminocresol isomers (4-hydroxy-m-toluidine [II], 3-hydroxy-p-toluidine [II], 2-hydroxy-p-toluidine [III]) and p-aminophenol have been separated and determined by a high-speed liquid Chromatographie method. Since this method is applicable in aqueous media, it was used to investigate the suitability of a haemin-cysteine system as a model for the cytochrome P-450 mono-oxygenase system, by determination of the [I], [II], [III] and p-aminophenol formed.
Sakurai
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Faculty of Pharmaceutical Sciences, University of Tokushima, Tokushima 770 Japan; Kyoto College of Pharmacy, Higashiyama-ku, Kyoto 607, Japan.
Kito
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