title: Progression of non-culprit coronary artery atherosclerosis after acute myocardial infarction in comparison with stable angina pectoris.
abstract: OBJECTIVE
  We previously found, using a mouse model, that activation of proinflammatory cytokines after acute myocardial infarction (AMI) augments neointimal hyperplasia of a remote artery. The present study assessed the progression of luminal narrowing of non-culprit coronary arteries (NCCA) in patients following AMI.
  
  
  METHODS
  The study group comprised 21 AMI patients successfully treated with bare-metal stents and 16 stable angina (SA) patients treated with sirolimus-eluting stents. Clinical backgrounds were similar for both groups. Quantitative coronary angiography was performed before and after stent implantation and at 6-months of follow-up.
  
  
  RESULTS
  We evaluated 126 non-culprit coronary segments (73 in AMI and 53 in SA). The minimum lumen diameter (MLD) (mm) of NCCA decreased significantly from 2.61+/-0.79 to 2.44+/-0.71 in the AMI group, but changed only slightly from 2.02+/-0.56 to 2.02+/-0.50 in the SA group. The absolute change in the MLD of NCCA was significantly greater (0.17+/-0.53) in the AMI, than in the SA (0.0070+/-0.261) group.
  
  
  CONCLUSIONS
  luminal narrowing of non-culprit coronary segments progressed in AMI patients within 6 months of stent implantation, but progressed only slightly in SA patients.
authors.affiliation: First Department of Internal Medicine, Nara Medical University, Nara, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Okayama
authors.forename: Shiro
authors.initials: S
authors.lastname: Uemura
authors.forename: Taku
authors.initials: T
authors.lastname: Nishida
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Morikawa
authors.forename: Kenji
authors.initials: K
authors.lastname: Onoue
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Takemoto
authors.forename: Tsunenari
authors.initials: T
authors.lastname: Soeda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Somekawa
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Ishigami
authors.forename: Yukiji
authors.initials: Y
authors.lastname: Takeda
authors.forename: Manabu
authors.initials: M
authors.lastname: Horii
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kawata
authors.forename: Minoru
authors.initials: M
authors.lastname: Takaoka
authors.forename: Tamio
authors.initials: T
authors.lastname: Nakajima
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Saito
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000473:pathology* / Q000628:therapy; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000473:pathology* / Q000628:therapy; D018450:Disease Progression; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction; D015607:Stents; D016896:Treatment Outcome