A method for recording single-cell activity in the frontal-pole cortex of macaque monkeys.
Neurophysiological research has explored most of the prefrontal cortex of macaque monkeys, but the relatively inaccessible frontal-pole cortex remains unexamined. Here we describe a method for gaining access to the frontal-pole cortex with moveable microelectrodes. The key innovation is a direct approach through the frontal air sinus. In addition, the small size of the frontal-pole cortex in macaques led to the design of a smaller recording chamber than typically used in behavioral neurophysiology. The method has proven successful in two subjects, with no adverse health consequences.
Mitz
Andrew R
AR
SN/Laboratory of Systems Neuroscience, National Institute of Mental Health, MSC 4401, Bethesda, MD 20892-4401, USA. arm@nih.gov
Tsujimoto
Satoshi
S
Maclarty
Arthur J
AJ
Wise
Steven P
SP
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D004558:Electric Stimulation / Q000379:methods; D004594:Electrophysiology / Q000295:instrumentation / Q000379:methods*; D005625:Frontal Lobe / Q000166:cytology*; D008253:Macaca mulatta; D008297:Male; D008839:Microelectrodes; D009474:Neurons / Q000502:physiology*