[Study on self-microemulsifying drug delivery system of Jiaotai Pill active components].
OBJECTIVE
To develop self-microemulsifying drug delivery system (SMEDDS) of Jiaotai Pill active components and its quality control method.


METHODS
The solubility of berberine hydrochloride in different auxiliary-materials were investigated, and the self-microemulsion formula was optimized by studying the self-microemulsifying efficiency. The content of berberine hydrochloride and cinnamaldehyde in the preparation were determined by HPLC.


RESULTS
The optimal self-microemulsion formula was composed of OP, propanediol, cinnamon oil, and total alkaloid from Rhizoma Coptidis with the ratio of 4:8:3:6. The average size of the microemulsion particle was 15.8 nm; the average content of berberine hydrochloride and cinnamaldehyde in the preparation was above 20.0% and 10.0%, respectively.


CONCLUSIONS
The acquired microemulsion with small particle size is stable. The determination method of berberine hydrochloride and cinnamaldehyde in the preparation is accurate and reliable.
Zhang
Bei-En
BE
Guangzhou University of TCM, Guangzhou 510006, China. beien_83@yahoo.com.cn
Lu
Wen-Biao
WB
Chen
Wei-Wen
WW
D001599:Berberine / Q000032:analysis; D002851:Chromatography, High Pressure Liquid; D002934:Cinnamates / Q000032:analysis; D039323:Coptis / Q000737:chemistry; D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry*; D019770:Lauraceae / Q000737:chemistry; D010316:Particle Size; D010938:Plant Oils / Q000008:administration & dosage / Q000737:chemistry; D011409:Propylene Glycols / Q000008:administration & dosage / Q000737:chemistry; D011786:Quality Control; D012995:Solubility
D002934:Cinnamates; D004365:Drugs, Chinese Herbal; D010938:Plant Oils; D011409:Propylene Glycols; C000588549:jiaotai; D001599:Berberine