title: [Two cases of primary unresectable and/or recurrent gastrointestinal stromal tumors of small intestine presenting hemoperitoneum caused by administration of imatinib mesylate].
abstract: Case1 was a 52-year-old man who had recurrence of postoperative intra-abdominal disseminations from gastrointestinal stromal tumor (GIST) of the jejunum. Case2 was a 66-year-old man who had GIST of the jejunum with multiple liver metastases. Two cases presented hemoperitoneum caused by administration of imatinib mesylate, and we conducted emergent surgery. In spite of surgically non-curative cases, it is suggested that the surgical management for GIST of high grade group with peritoneal exposure should be followed by the administration of imatinib mesylate.
authors.affiliation: Department of Gastroenterology, Iwaki Kyoritsu General Hospital.
authors.forename: Akira
authors.initials: A
authors.lastname: Yokoyama
authors.forename: Naohiro
authors.initials: N
authors.lastname: Dairaku
authors.forename: Masao
authors.initials: M
authors.lastname: Kusano
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Koshita
authors.forename: Norihiro
authors.initials: N
authors.lastname: Shimada
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yamagiwa
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kojima
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Ojima
authors.forename: Shinichi
authors.initials: S
authors.lastname: Ikeya
authors.forename: Haruo
authors.initials: H
authors.lastname: Nakayama
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Sugai
authors.forename: Nobuo
authors.initials: N
authors.lastname: Hiwatashi
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Asano
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D001549:Benzamides; D003131:Combined Modality Therapy; D013505:Digestive System Surgical Procedures; D004630:Emergencies; D017809:Fatal Outcome; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy* / Q000601:surgery*; D006465:Hemoperitoneum / Q000139:chemically induced*; D006801:Humans; D000068877:Imatinib Mesylate; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010879:Piperazines / Q000009:adverse effects* / Q000627:therapeutic use*; D011743:Pyrimidines / Q000009:adverse effects* / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate