title: The synthesis and preliminary activity assay in vitro of peptide-like derivatives as APN inhibitors.
abstract: Both the aminopeptidase N (APN) and matrix metalloproteinase (MMP) are essential metallopeptidases in the development of tumor invasion and angiogenesis. A series of novel peptide-like derivatives were designed and synthesized as antitumor agents. Their structures were confirmed by IR, MS, and (1)H-NMR. These compounds exhibited potent inhibitory activities against APN and low activity against MMP in vitro. The derivatives with methoxy group show better activities than those with other substituted group and could be used as lead compounds for exploring new APN inhibitors in the future.
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, PR China.
authors.forename: Shao-hua
authors.initials: SH
authors.lastname: Li
authors.forename: Gang
authors.initials: G
authors.lastname: Li
authors.forename: Hui-ming
authors.initials: HM
authors.lastname: Huang
authors.forename: Fang
authors.initials: F
authors.lastname: Xiong
authors.forename: Cheng-mei
authors.initials: CM
authors.lastname: Liu
authors.forename: Guo-gang
authors.initials: GG
authors.lastname: Tu
mesh_terms: D018826:CD13 Antigens / Q000037:antagonists & inhibitors*; D004926:Escherichia coli / Q000737:chemistry; D006860:Hydrogen Bonding; D013058:Mass Spectrometry; D061965:Matrix Metalloproteinase Inhibitors; D010455:Peptides / Q000138:chemical synthesis* / Q000494:pharmacology*; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared
chemical_list: D061965:Matrix Metalloproteinase Inhibitors; D010455:Peptides; D011480:Protease Inhibitors; D018826:CD13 Antigens