title: Three simple spectrophotometric methods for the determination of sulphinpyrazone.
abstract: Three simple and sensitive spectrophotometric methods for the determination of sulphinpyrazone (SP) in bulk samples and pharmaceutical formulations are described. They are based on the oxidation of sulphinpyrazone with excess N-bromosuccinimide (NBS) and determination of the unconsumed NBS with metol-isonicotinic acid hydrazide (method A, lambda(max): 620 nm); by the reduction of Folin-Ciocalteu reagent (method B, lambda(max) 770 nm); or by the formation of a chloroform-soluble, coloured ion-association complex between the drug and Methylene Violet (MV) at pH 7.0 (method C, lambda(max) 545 nm).
authors.affiliation: Foods and Drugs Laboratories, School of Chemistry, Andhra University, Visakhapatnam 530 003, India.
authors.forename: C S
authors.initials: CS
authors.lastname: Sastry
authors.forename: A
authors.initials: A
authors.lastname: Sailaja
authors.forename: T T
authors.initials: TT
authors.lastname: Rao
authors.forename: D M
authors.initials: DM
authors.lastname: Krishna