title: Severe vitamin B-12 deficiency in a child mimicking thrombotic thrombocytopenic purpura.
abstract: We report a case of severe vitamin B-12 deficiency in a child who had a clinical presentation of hemolysis and thrombocytopenia that suggested the diagnosis of thrombotic thrombocytopenic purpura (TTP) and was associated with decreased ADAMTS13 activity. In this report, we review vitamin B-12 deficiency in children, the relationship between ADAMTS13 activity and TTP and discuss other conditions associated with decreased ADAMTS13 activity.
authors.affiliation: Department of Hematology Oncology, Children's Hospital Oakland, Oakland, California 94609, USA. adimond@gmail.com
authors.forename: Andrea
authors.initials: A
authors.lastname: Dimond
authors.forename: James N
authors.initials: JN
authors.lastname: George
authors.forename: Caroline
authors.initials: C
authors.lastname: Hastings
mesh_terms: D000293:Adolescent; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D011697:Purpura, Thrombotic Thrombocytopenic / Q000175:diagnosis* / Q000473:pathology; D014806:Vitamin B 12 Deficiency / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology