Immune regulation of bone loss by Th17 cells.
A significant macrophage and T-cell infiltrate commonly occurs in inflammatory joint conditions such as rheumatoid arthritis that have significant bone destruction. Cytokines produced by activated macrophages and T cells are implicated in arthritis pathogenesis and are involved in osteoclast-mediated bone resorption. The scope of the present review is to analyze current knowledge and to provide a better understanding of how macrophage-derived factors promote the differentiation of a novel T-helper subset (Th17) that promotes osteoclast formation and activation.
Adamopoulos
Iannis E
IE
Department of Immunology, Schering Plough Biopharma, 901 California Avenue, Palo Alto, CA 94304, USA. iannis.adamopoulos@spcorp.com
Bowman
Edward P
EP
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000473:pathology; D001862:Bone Resorption / Q000276:immunology* / Q000473:pathology; D002454:Cell Differentiation; D006801:Humans; D010010:Osteoclasts / Q000166:cytology; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*