title: Simultaneous spectrophotometric determination of drugs in pharmaceutical preparations using multiple linear regression and partial least-squares regression, calibration and prediction methods.
abstract: Two new methods for the simultaneous determination of acetylsalicylic acid, acetaminophen and caffeine based on total absorbance measurements and their processing by multiple linear regession and partial least-squares regression are proposed. The concentration ranges used to construct the calibration matrix were 4.0-12.0, 2.0-10.0 and 0.9-6.0 mug ml(-1) for acetylsalicylic acid, acetaminophen and caffeine respectively. The proposed methods were validated by using a set of synthetic sample mixtures and subsequently applied to the determination of the three active principles in three different pharmaceutical preparations.
authors.forename: R D
authors.initials: RD
authors.lastname: Bautista
authors.forename: F J
authors.initials: FJ
authors.lastname: Aberásturi
authors.forename: A I
authors.initials: AI
authors.lastname: Jiménez
authors.forename: F
authors.initials: F
authors.lastname: Jiménez