Patient with obstructive sleep apnea-hypopnea syndrome and SCN5A mutation (R1193Q polymorphism) associated with Brugada type 2 electrocardiographic pattern.
We describe a 45-year-old Asian man with Brugada-type 2 electrocardiogram and probable nocturnal agonal respiration. After genetic screening, drug challenge test and polysomnography examination, we ruled out Brugada syndrome and identified obstructive sleep apnea-hypopnea syndrome. Therefore, obstructive sleep apnea-hypopnea syndrome should be considered as a rare differential diagnosis for Brugada syndrome.
Qiu
Xiaoliang
X
Heart Center, Peking University People's Hospital, Beijing, PR China.
Liu
Wenling
W
Hu
Dayi
D
Sun
Yihong
Y
Li
Lei
L
Li
Cuilan
C
D053840:Brugada Syndrome / Q000150:complications / Q000175:diagnosis* / Q000235:genetics*; D003937:Diagnosis, Differential; D004562:Electrocardiography / Q000379:methods*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000175:diagnosis* / Q000235:genetics*