title: Collisionally induced fragmentation of [M-H](-) species of resveratrol and piceatannol investigated by deuterium labelling and accurate mass measurements.
abstract: Resveratrol (3,5,4'-trihydroxystilbene) and piceatannol (3,4,3',5'-tetrahydroxy-trans-stilbene) are phytoalexins present in red grapes and wines. In vitro studies have revealed that piceatannol blocks LMP2A, a viral protein-tyrosine kinase implicated in leukemia, non-Hodgkin's lymphoma and other diseases associated with the Epstein-Barr virus, and has an antimelanoma effect on human melanoma cells. Resveratrol has several beneficial effects on human health, such as anticancer, cardioprotection, antioxidant, inhibition of platelet aggregation and anti-inflammatory activity. In this investigation, the collisional behaviour of deprotonated resveratrol and piceatannol obtained under electrospray conditions is described. The mechanisms involved in the fragmentation pattern of [M-H](-) species of the two compounds were investigated by performing MS(n) experiments, deuterium labelling and accurate mass measurements.
authors.affiliation: CNR-ISTM, Sezione di Padova, Corso Stati Uniti 4, 35100 Padova.
authors.forename: Laura
authors.initials: L
authors.lastname: Stella
authors.forename: Mirko
authors.initials: M
authors.lastname: De Rosso
authors.forename: Annarita
authors.initials: A
authors.lastname: Panighel
authors.forename: Antonio Dalla
authors.initials: AD
authors.lastname: Vedova
authors.forename: Riccardo
authors.initials: R
authors.lastname: Flamini
authors.forename: Pietro
authors.initials: P
authors.lastname: Traldi
mesh_terms: D003903:Deuterium; D041961:Deuterium Exchange Measurement / Q000379:methods*; D008970:Molecular Weight; D000077185:Resveratrol; D012717:Sesquiterpenes; D021241:Spectrometry, Mass, Electrospray Ionization; D013267:Stilbenes / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry; D000094162:Phytoalexins
chemical_list: D012717:Sesquiterpenes; D013267:Stilbenes; D013729:Terpenes; C041525:3,3',4,5'-tetrahydroxystilbene; D003903:Deuterium; D000077185:Resveratrol; D000094162:Phytoalexins