FIA titrations of phenothiazine derivatives in aqueous micellar and non-aqueous media.
New methods of flow injection analysis (FIA) neutralization titrations of phenothiazine derivatives in aqueous micellar medium of a cationic surfactant using potentiometric and spectrophotometric detection were proposed; titrations with a mixing gradient chamber and high-speed titrations were compared. The FIA titration method in non-aqueous media based on an official method of determination (titration with perchloric acid in anhydrous acetic acid) was also developed. Under optimized reaction conditions and flow-through parameters, the calibration range and equations, the sensitivity, and the repeatability of all methods were found and discussed. All titrations were assayed for medicinal forms.
Nemcová
Irena
I
Department of Analytical Chemistry, Faculty of Science, Charles University of Prague, Albertov 2030, CZ-12843 Prague 2, Czech Republic.
Nesmerák
Karel
K
Rychlovský
Petr
P
Koutníková
Jitka
J