title: Voltammetric studies of the effect of Cisplatin-liposome on Hela cells.
abstract: In this paper, the voltammetric method was used for the first time to study the effect of Cisplatin-liposome on Hela cells. The results showed the voltammetric behavior of Hela cells was irreversible and the peak current had linear relationship with the cell number. With both Cisplatin-liposome concentration and treating time increasing, the peak current decreased. The peak current decreasing was in accordance with the nuclear damage and loss of mitochondrial membrane potential revealed by two-photon laser scanning microscopy and confocal laser scanning microscopy. This voltammetric method may provide a simple way to study the electron-transfer mechanism in drug-treating cells.
authors.affiliation: Department of Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
authors.forename: Y X
authors.initials: YX
authors.lastname: Ci
authors.forename: Q
authors.initials: Q
authors.lastname: Zhai
authors.forename: S
authors.initials: S
authors.lastname: Wang
authors.forename: W B
authors.initials: WB
authors.lastname: Chang
authors.forename: C Y
authors.initials: CY
authors.lastname: Zhang
authors.forename: H
authors.initials: H
authors.lastname: Ma
authors.forename: D Y
authors.initials: DY
authors.lastname: Chen
authors.forename: M Z
authors.initials: MZ
authors.lastname: Zhao
authors.forename: S W
authors.initials: SW
authors.lastname: Hu