Reliability of protonation constants of SNAZOXS oligomers.
Concentration protonation constants of variously protonated of oligomers of sulphoazoxine SNAZOXS were determined by regression analysis of potentiometric titration curves. The group and common parameters were estimated using different computational strategies of three regression programs, MINIQUAD, MIQUV and PSEQUAD. ANOVA proved that six various computational strategies of three regression programs have no significant influence on reliability of protonation constants estimated in comparison with the reproducibility of the titration. Chemical model of protonation equilibria L(2)H(5-), L(2)H(4-)(2), L(2)H(3-)(3), and L(2)H(2-)(4) and reaction scheme of oligomers protonation for SNAZOXS was found.
Meloun
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Department of Analytical Chemistry, University of Chemical Technology, 532 10 Pardubice, Czech Republic.
Centner
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