The influence of the preparation methods on the inclusion of model drugs in a beta-cyclodextrin cavity.
The work aims to prove the complexation of two model drugs (ibuprofen, IB and indomethacin, IN) by beta-cyclodextrin (betaCD), and the effect of water in such a process, and makes a comparison of their complexation yields. Two methods were considered: kneading of a binary mixture of the drug, betaCD, and inclusion of either IB or IN in aqueous solutions of betaCD. In the latter method water was removed by air stream, spray-drying and freeze-drying. To prove the formation of complexes in final products, optical microscopy, UV spectroscopy, IR spectroscopy, DSC, X-ray and NMR were considered. Each powder was added to an acidic solution (pH=2) to quantify the concentration of the drug inside betaCD cavity. Other media (pH=5 and 7) were used to prove the existence of drug not complexed in each powder, as the drugs solubility increases with the pH. It was observed that complexation occurred in all powders, and that the fraction of drug inside the betaCD did not depend neither on the method of complexation nor on the processes of drying considered.
Salústio
P J
PJ
iMed.UL (Research Institute for Medicines and Pharmaceutical Sciences), Faculdade de Farmácia da Universidade de Lisboa, P-1649-003 Lisboa, Portugal.
Feio
G
G
Figueirinhas
J L
JL
Pinto
J F
JF
Cabral Marques
H M
HM
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004337:Drug Carriers / Q000737:chemistry*; D005612:Freeze Drying; D006863:Hydrogen-Ion Concentration; D007052:Ibuprofen / Q000737:chemistry*; D007213:Indomethacin / Q000737:chemistry*; D011208:Powders; D012995:Solubility; D047392:beta-Cyclodextrins / Q000737:chemistry*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D011208:Powders; D047392:beta-Cyclodextrins; C031215:betadex; D007052:Ibuprofen; D007213:Indomethacin