Determination of pimozide in oral preparations by spectrofluorometry.
The intense native fluorescence of pimozide is reported. It is due to the benzo-1,3-diazolin-2-one fraction of the molecule, also present in the structurally analogous benperidol molecule. The fluorescence intensity is nearly independent of solvent acidity. This substance can be determined in oral preparations by its native fluorescence in diethyl ether (lambda(EXC) = 290 nm. lambda = 319 nm) with a detection limit of 0.01 mug/ml.
Baeyens
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State University of Ghent, Faculty of Pharmaceutical Sciences, Laboratory for Pharmaceutical Chemistry and Drug Analysis, De Pintelaan 135, 9000-Ghent, Belgium.