title: [Liver biopsy in liver patients with coagulopathy].
abstract: The risk of severe bleeding after liver biopsy is estimated to be 1:12,000 in patients with near normal coagulation (INR < 1,5 and platelet count > 60 billion /l). Beyond these limits, the risk is higher, but still uncertain. The Danish guidelines require INR > 1.5, platelet count < 40 billion /l and normal APTT. In some instances the risk of not knowing the histology is so high that a biopsy is considered even with a more disturbed coagulation. Vitamin K, freshly frozen plasma and recombinant activated factor VII may reduce the risk of bleeding in specific situations, but no firm recommendations can be given.
authors.affiliation: Medicinsk Hepato-gastroenterologisk Afdeling V, Arhus Universitetshospital, Arhus Sygehus, DK-8000 Arhus C. peott@as.aaa.dk
authors.forename: Peter
authors.initials: P
authors.lastname: Ott
authors.forename: Henning
authors.initials: H
authors.lastname: Grønbaek
authors.forename: Jens Otto
authors.initials: JO
authors.lastname: Clemmesen
authors.forename: Mette Rye
authors.initials: MR
authors.lastname: Clausen
authors.forename: André
authors.initials: A
authors.lastname: Wettergren
authors.forename: Troels
authors.initials: T
authors.lastname: Havelund
authors.forename: Erik
authors.initials: E
authors.lastname: Feldager
authors.forename: Flemming
authors.initials: F
authors.lastname: Bendtsen
authors.forename: Bent Adel
authors.initials: BA
authors.lastname: Hansen
authors.forename: Ulrik
authors.initials: U
authors.lastname: Tage-Jensen
authors.forename: Lars Peter
authors.initials: LP
authors.lastname: Larsen
authors.forename: Hendrik
authors.initials: H
authors.lastname: Vilstrup
mesh_terms: D001706:Biopsy / Q000009:adverse effects*; D001778:Blood Coagulation Disorders / Q000150:complications* / Q000473:pathology; D000075202:Contraindications; D006470:Hemorrhage / Q000209:etiology* / Q000517:prevention & control; D006801:Humans; D019934:International Normalized Ratio; D008099:Liver / Q000473:pathology*; D008107:Liver Diseases / Q000150:complications* / Q000473:pathology; D010976:Platelet Count; D012307:Risk Factors