title: Measurement of disease activity and damage in Sjögren's syndrome.
abstract: Sjögren's syndrome (SS) is a systemic autoimmune disease that is characterized by an aggressive autoimmune response to epithelia, with consequent reduction of their secretions accompanied by sicca complaints. Systemic features may also be present in a subset of patients and may require more aggressive therapies. Improvements in knowledge concerning disease pathophysiology, combined with the availability of specifically targeted therapies able to modulate or block some of the most important pathologic mechanisms of the disease, may open totally new perspectives in the therapeutic approach to SS. The absence of reliable and validated outcome measures for SS is a major obstacle in performing clinical trials of new therapies in SS but studies devoted to defining outcome measurement instruments for this disorder have been performed or are in an advanced phases of completion.
authors.affiliation: Department of Internal Medicine and Section of Rheumatology, 'Villamarina' Hospital, Piombino, Italy. c.vitali@yahoo.it
authors.forename: Claudio
authors.initials: C
authors.lastname: Vitali
mesh_terms: D001327:Autoimmune Diseases / Q000175:diagnosis / Q000276:immunology; D006801:Humans; D017063:Outcome Assessment, Health Care; D020127:Recovery of Function; D012008:Recurrence; D012720:Severity of Illness Index; D012859:Sjogren's Syndrome / Q000175:diagnosis* / Q000276:immunology