Traditional and non traditional risk factors in accelerated atherosclerosis in systemic lupus erythematosus: role of vascular endothelial growth factor (VEGATS Study).
OBJECTIVE
To evaluate the role of vascular endothelial growth factor (VEGF) in accelerated atherosclerosis in patients with Systemic Lupus Erythematosus (SLE).


METHODS
We have enrolled 80 SLE female patients and 80 age-matched healthy control females who underwent a structured interview, physical examination, routine laboratory tests, VEGF plasma level determination and B-mode ultrasonography of carotid arteries to determine carotid intima media thickness (IMT). Framingham risk factors for cardiovascular events were also calculated and VEGF plasma levels were correlated with traditional and nontraditional cardiovascular risk factors.


RESULTS
SLE was significantly associated with higher mean IMT values (0.74+/-0.15 mm versus 0.59+/-0.12 mm in controls, p<0.001) and higher mean plasma VEGF levels (307.9+/-292.2 pg/mL versus 120.7+/-118.4 pg/mL in controls, p<0.001) independently from age, smoking habits, and Framingham risk factors. A significant correlation was also found between IMT and VEGF values (r=0.25; p<0.001).


CONCLUSIONS
We show that SLE patients have increased mean IMT and VEGF values as compared with healthy age-matched controls and that IMT and VEGF values are independently and directly associated with SLE disease.
Colombo
Barbara Maria
BM
Department of Internal Medicine, University of Genoa, Italy. bmcolombo@libero.it
Cacciapaglia
Fabio
F
Puntoni
Matteo
M
Murdaca
Giuseppe
G
Rossi
Edoardo
E
Rodriguez
Guido
G
Nobili
Flavio
F
Pisciotta
Livia
L
Bertolini
Stefano
S
Moccetti
Tiziano
T
Dentali
Francesco
F
Steidl
Luigi
L
Ciprandi
Giorgio
G
Afeltra
Antonella
A
Indiveri
Francesco
F
Puppo
Francesco
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D050197:Atherosclerosis / Q000000981:diagnostic imaging*; D002339:Carotid Arteries / Q000000981:diagnostic imaging; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007407:Interviews as Topic; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000000981:diagnostic imaging; D008875:Middle Aged; D012307:Risk Factors; D017539:Tunica Intima / Q000473:pathology; D017540:Tunica Media / Q000473:pathology; D014463:Ultrasonography; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*; D055815:Young Adult
C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A