Drugs during lactation accenting boron exposure.
OBJECTIVE
The benefits of breastfeeding are generally accepted. Risk of drug usage for baby due to lactation is well assessed minimally in certain cases. However, information given about drugs are often insufficient, frustrating, and not recommending lactation. In Czech Teratology Information Service (CZTIS) counselling we use these information.


RESULTS
We have given advice in 58 cases inquiring the CZTIS about the risk of drug exposure during lactation. The most frequent queries were on chronic disease treatment following the drug exposure during pregnancy. Remaining cases were associated with acute infections. Mothers suffered from idiopathic bowel disease and psychiatric patients want to be informed before delivery about possibility to breastfeed their babies. Treatment of epilepsy, another frequent disease, is associated with better level of knowledge of both, neurologists and patients. Breastfeeding is recommended according to management in care of epileptic women.


CONCLUSIONS
In our counselling we consider the factors which are involved in drug transfer in the milk and mechanisms and steps of transfer as well. We follow the classification of drugs during lactation by their effect on infants: absolutely contraindicated, temporary cessation of breastfeeding, drugs of special concern and drugs compatible with breastfeeding.
Manakova
Eva
E
Czech Teratology Information Service, Department of Histology and Embryology, 3rd Faculty of Medicine, Charles University in Prague, Czech Republic. eva.manak@post.cz
Hubickova-Heringova
Lucie
L
Novakova
Lucie
L
D000328:Adult; D000891:Anti-Infective Agents, Local / Q000009:adverse effects* / Q000378:metabolism*; D000927:Anticonvulsants / Q000009:adverse effects / Q000493:pharmacokinetics; D001682:Biological Availability; D001888:Boric Acids / Q000009:adverse effects* / Q000378:metabolism*; D001942:Breast Feeding / Q000009:adverse effects*; D018153:Czech Republic; D004346:Drug Information Services / Q000706:statistics & numerical data*; D064420:Drug-Related Side Effects and Adverse Reactions; D004827:Epilepsy / Q000150:complications; D005260:Female; D006207:Half-Life; D006801:Humans; D007231:Infant, Newborn; D008895:Milk, Human / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011247:Pregnancy
D000891:Anti-Infective Agents, Local; D000927:Anticonvulsants; D001888:Boric Acids; D004364:Pharmaceutical Preparations; C032688:boric acid