Oxidative stress early in pregnancy and pregnancy outcome.
The objectives of this study were to determine whether oxidative stress early in pregnancy influenced pregnancy outcome. A combination of assays were used for exogenous and endogenous anti-oxidants together with two well accepted biomarkers for oxidative stress, the urinary excretion of 8-iso-PGF(2alpha) (a biomarker marker for lipid oxidation, n=508) and 8-oxo-7,8 dihydro-2 deoxyguanosine (8-OHdG, a biomarker for DNA oxidation, n=487). The two biomarkers tracked different pregnancy outcomes. Isoprostanes were associated with an increased risk of pre-eclampsia and a decreased proportion of female births. In contrast, 8-OHdG tracked lower infant birthweight and shortened gestation duration. Birth defects were associated with low levels of 8-OHdG.
Peter Stein
T
T
Department of Surgery, University of Medicine and Dentistry of New Jersey-SOM, Stratford, NJ 08084, USA. tpstein@umdnj.edu
Scholl
Theresa O
TO
Schluter
Margaret D
MD
Leskiw
Maria J
MJ
Chen
Xinhua
X
Spur
Bernd W
BW
Rodriguez
Ana
A
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001724:Birth Weight; D000013:Congenital Abnormalities / Q000378:metabolism; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D015237:Dinoprost / Q000031:analogs & derivatives / Q000652:urine; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D016877:Oxidants / Q000097:blood; D018384:Oxidative Stress; D011225:Pre-Eclampsia / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism*; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000378:metabolism; D011446:Prospective Studies; D055815:Young Adult
D000975:Antioxidants; D015415:Biomarkers; D016877:Oxidants; C075750:8-epi-prostaglandin F2alpha; D000080242:8-Hydroxy-2'-Deoxyguanosine; D015237:Dinoprost; D003849:Deoxyguanosine