title: Cytotoxic triterpenoid saponins from the roots of Ardisia crenata.
abstract: Ardisiacrenoside I (1), a new triterpenoid pentasaccharide with an unusual glycosyl glycerol side chain, was isolated from Ardisia crenata together with five closely related triterpenoid saponins. Their structures were elucidated by a combination of mass spectrometry, IR, 1D, and 2D NMR spectroscopy. Their cytotoxic activities were evaluated against several different human tumor cell lines by the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) method.
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Ministry of Education), Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Bejing, China.
authors.forename: Zhong-Fei
authors.initials: ZF
authors.lastname: Zheng
authors.forename: Jian-Fu
authors.initials: JF
authors.lastname: Xu
authors.forename: Zi-Ming
authors.initials: ZM
authors.lastname: Feng
authors.forename: Pei-Cheng
authors.initials: PC
authors.lastname: Zhang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D031644:Ardisia / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D014315:Triterpenes; C539034:ardisiacrenoside I