title: Buschke-Ollendorff syndrome.
abstract: BACKGROUND
  Buschke-Ollendorff syndrome is a rare autosomal dominant disease featuring osteopoikilosis and skin lesions. It is caused by genetic mutations in a protein deeply involved in bone and connective tissue morphogenesis.
  
  
  METHODS
  We describe a 39-year-old woman with Buschke-Ollendorff syndrome.
  
  
  RESULTS
  After a minor trauma, radiologic examination of the left ankle of a 39-year-old woman revealed features of osteopoikilosis. Physical examination of the patient showed multiple asymptomatic nodules on both thighs, present since the age of 20 years, which had increased in size and number. Recently, a linear, string-like lesion had appeared on the right thigh.
  
  
  CONCLUSIONS
  The correct diagnosis of Buschke-Ollendorff syndrome may require a high index of suspicion.
authors.affiliation: Department of Biomedical and Surgical Sciences, Section of Dermatology and Venereology, University of Verona, Verona, Italy. donatella.schena@azosp.vr.it
authors.forename: Donatella
authors.initials: D
authors.lastname: Schena
authors.forename: Lerica
authors.initials: L
authors.lastname: Germi
authors.forename: Maria Rosa
authors.initials: MR
authors.lastname: Zamperetti
authors.forename: Chiara
authors.initials: C
authors.lastname: Colato
authors.forename: Giampiero
authors.initials: G
authors.lastname: Girolomoni
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007868:Leg Dermatoses / Q000175:diagnosis* / Q000473:pathology; D010023:Osteopoikilosis / Q000175:diagnosis* / Q000473:pathology; D012867:Skin / Q000473:pathology; D012873:Skin Diseases, Genetic / Q000175:diagnosis* / Q000473:pathology; D013577:Syndrome