Homogeneous sulfation of bagasse cellulose in an ionic liquid and anticoagulation activity.
Homogeneous sulfation of bagasse cellulose (BC) with chlorosulfonic acid-dimethylformamide was accomplished in an ionic liquid 1-butyl-3-methylimidazolium chloride ([C(4)mim]Cl). The BCS products from the sulfation had degrees of substitution (DS) in the range of 0.52-2.95 and a simultaneous substitution pattern at C-6, C-2 and C-3 positions. The sulfated BCS attained significant anticoagulation activity, causing a dose-dependent prolongation of coagulation time and inhibition of FIIa and FXa activities in human plasma. The anticoagulation activity of BCS showed a positive correlation with DS, and some of the activity indexes exceeded those of heparin.
Wang
Zhao-Mei
ZM
Research Institute of Light Industry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China.
Li
Lin
L
Xiao
Kai-Jun
KJ
Wu
Jian-Yong
JY
D000925:Anticoagulants / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects; D002482:Cellulose / Q000378:metabolism* / Q000494:pharmacology*; D015956:Factor XIIa / Q000037:antagonists & inhibitors; D065427:Factor Xa Inhibitors; D006493:Heparin / Q000378:metabolism; D006801:Humans; D052578:Ionic Liquids / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D013431:Sulfates / Q000378:metabolism*; D013918:Thrombin Time
D000925:Anticoagulants; D065427:Factor Xa Inhibitors; D052578:Ionic Liquids; D013431:Sulfates; D002482:Cellulose; D006493:Heparin; C027433:bagasse; D015956:Factor XIIa