Depleting T-cell subpopulations in organ transplantation.
T-cell depletion strategies are an efficient therapy for the treatment of acute rejection after organ transplantation and have been successfully used as induction regimens. Although eliminating whole T cells blocks alloreactivity, this therapy challenges the development of regulatory mechanisms because it depletes regulatory cells and modifies the profile of T cells after homeostatic repopulation. Targeting T-cell subpopulations or selectively activated T cells, without modifying Treg cells, could constitute a pro-tolerogenic approach. However, the perfect molecular target that would be totally specific probably still needs to be identified. In this study, we have reviewed the biological activities of broad or specific T-cell depletion strategies as these contribute to the induction of regulatory cells and tolerance in organ transplantation.
Haudebourg
Thomas
T
INSERM, U643, CHU Nantes, Institut de Transplantation et de Recherche en Transplantation, ITERT, Université de Nantes, Faculté de Médecine, Nantes, France.
Poirier
Nicolas
N
Vanhove
Bernard
B
D000818:Animals; D015703:Antigens, CD / Q000276:immunology / Q000627:therapeutic use; D000951:Antigens, Neoplasm / Q000627:therapeutic use; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D018106:CD28 Antigens / Q000276:immunology; D017252:CD3 Complex / Q000627:therapeutic use; D015704:CD4 Antigens / Q000276:immunology; D023201:CD40 Ligand / Q000276:immunology; D000074301:CD52 Antigen; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D006023:Glycoproteins / Q000627:therapeutic use; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D053645:Interleukin-2 Receptor alpha Subunit / Q000276:immunology; D017493:Leukocyte Common Antigens / Q000276:immunology; D008212:Lymphocyte Depletion; D013601:T-Lymphocytes / Q000276:immunology*; D014184:Transplantation, Homologous / Q000276:immunology*; D000093322:Lymphocyte Activation Gene 3 Protein
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D000961:Antilymphocyte Serum; D018106:CD28 Antigens; D017252:CD3 Complex; D015704:CD4 Antigens; D000074301:CD52 Antigen; C000613862:CD52 protein, human; D006023:Glycoproteins; D053645:Interleukin-2 Receptor alpha Subunit; D023201:CD40 Ligand; D017493:Leukocyte Common Antigens; D000093322:Lymphocyte Activation Gene 3 Protein; C000720326:Lag3 protein, human