Covalent double level dynamic combinatorial libraries: selectively addressable exchange processes.
Hydrazones and disulfides have been combined in one dynamic system: hydrazones were exchanged by acid catalysis in the presence of disulfide and a thiol group without interference; neutralization of the reaction medium turns off the exchange of hydrazones and, at the same time, activates thiolate-disulfide exchange.
Orrillo
A Gastón
AG
Farmacognosia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina.
Escalante
Andrea M
AM
Furlan
Ricardo L E
RL
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D004220:Disulfides / Q000737:chemistry; D005021:Ethylamines / Q000737:chemistry; D006835:Hydrazones / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000737:chemistry; D014269:Trifluoroacetic Acid / Q000737:chemistry
D004220:Disulfides; D005021:Ethylamines; D006835:Hydrazones; D013438:Sulfhydryl Compounds; D014269:Trifluoroacetic Acid; C016162:triethylamine