[Regional vasotropic and hepatotropic therapy in the complex treatment of postoperative purulent peritonitis].
In 8 patients, operated for postoperative spreaded purulent peritonitis, umbilical vein was catheterized, postoperatively angiographic investigation was performed, leaving catheter in tr. coeliacus or a. mesenterica superior, through which regionary hemodilution, using drop infusion of 20 mcg of alprostan during 3-4 days. Additionally, to all the patients intraportal hemodilution with hepatoprotector thiotriazoline infusion was performed. Application of the treatment measures complex proposed had assisted an early restoration of splanchnic microcirculation, significant lowering of endogenic intoxication severity, rapid restoration of hepatic functional activity, reduction of systemic inflammatory answer expression.
Gusak
I V
IV
Ivanova
Iu V
IuV
Avdos'ev
Iu V
IuV
Moskalenko
A V
AV
D018806:APACHE; D000328:Adult; D000527:Alprostadil / Q000008:administration & dosage / Q000627:therapeutic use; D000792:Angiography; D003131:Combined Modality Therapy; D013505:Digestive System Surgical Procedures / Q000009:adverse effects*; D006438:Hemodilution; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000187:drug effects; D008833:Microcirculation / Q000187:drug effects / Q000502:physiology; D008875:Middle Aged; D009025:Morpholines / Q000008:administration & dosage / Q000627:therapeutic use; D010538:Peritonitis / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D013152:Splanchnic Circulation / Q000187:drug effects* / Q000502:physiology; D013492:Suppuration; D016896:Treatment Outcome; D014230:Triazoles / Q000008:administration & dosage / Q000627:therapeutic use; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use
D009025:Morpholines; D014230:Triazoles; D014665:Vasodilator Agents; C435843:morpholinium 3-methyl-1,2,4-triazoline-5-thioacetate; D000527:Alprostadil