title: Monitoring of mutagenic process with piezoelectric quartz crystal impedance analysis.
abstract: A novel method for monitoring of mutagenic process of dimethyl sulfate to Salmonella typhimurium strain (TA100) was proposed by using piezoelectric quartz crystal impedance (PQCI) analysis technique. The time courses of responses piezoelectric impedance parameters for a quartz crystal in a culture system were simultaneously obtained and discussed. It was found that the motional resistance variation (DeltaR(m)) increases and frequency shift (Deltaf) of PQC sensor decreases correspondingly during the mutagenic process of the bacteria. These parameters could reflect the variations of viscosity and density of culture system. By fitting DeltaR(m) versus time curves toward Gompertz bacterial growth model, we obtained and discussed the bacterial growth parameters for both normal growth and mutagenic process. The experiments showed that the proposed method could provide real time and multidimensional impedance information to the monitoring of mutagenic process.
authors.affiliation: College of Chemistry and Chemical Engineering, Hunan University, Hunan, Changsha 410082, People's Republic of China.
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: W
authors.initials: W
authors.lastname: Wei
authors.forename: A
authors.initials: A
authors.lastname: Zhou
authors.forename: D
authors.initials: D
authors.lastname: He
authors.forename: S
authors.initials: S
authors.lastname: Yao
authors.forename: Q
authors.initials: Q
authors.lastname: Xie