Glycopyrronium-selective electrodes.
Liquid-membrane and PVC-membrane glycopyrronium-selective electrodes have been developed. They are based on the ion-pair complexes of glycopyrronium with dicyclohexylnaphthalenesulphonate, di-isopentylnaphthalenesulphonate, di-isobutylnaphthalenesulphonate and tetraphenylborate. Their response is nearly Nernstian over the pH-range 4-8, and the detection limits range from 10(-6)M to 10(-5)M. For the liquid-membrane electrodes, with homologous membrane solvents, the response slopes are linearly related to the inverse of the dielectric constant of the membrane solvent, according to the formula S = C(o) - C(1)/. A similar relation exists between the slopes for both types of electrode and the dielectric constants of mixed-solvent backgrounds. The electrodes can be used in the potentiometric determination of glycopyrrolate.
Yao
S Z
SZ
New Material Research Institute, Department of Chemical Engineering, Hunan University, Changsha, People's Republic of China.
Liu
G H
GH