title: Phenotypic impact of resistance mutations on etravirine susceptibility in HIV patients with prior failure to nonnucleoside analogues.
abstract: The phenotypic impact on etravirine susceptibility was examined in plasma specimens from 40 nonnucleoside reverse transcriptase inhibitor-experienced HIV patients with distinct nonnucleoside reverse transcriptase inhibitor resistance-associated mutations. Some etravirine resistance-associated mutations produced larger reductions in fold change than others. Y181C in combination with at least one etravirine resistance-associated mutation caused, on average, a 12.6-fold reduced susceptibility to etravirine. Two novel changes, K101H and E399D, significantly diminished etravirine susceptibility. Thus, the original etravirine resistance-associated mutation list should be updated and weighted for a suitable genotypic resistance interpretation.
authors.affiliation: Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain. evapoveda@hotmail.com
authors.forename: Eva
authors.initials: E
authors.lastname: Poveda
authors.forename: Carmen
authors.initials: C
authors.lastname: de Mendoza
authors.forename: Theresa
authors.initials: T
authors.lastname: Pattery
authors.forename: María del Mar
authors.initials: Mdel M
authors.lastname: González
authors.forename: Jorge
authors.initials: J
authors.lastname: Villacian
authors.forename: Vincent
authors.initials: V
authors.lastname: Soriano
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D004198:Disease Susceptibility / Q000821:virology; D024882:Drug Resistance, Viral / Q000187:drug effects / Q000235:genetics*; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1 / Q000235:genetics; D006801:Humans; D009570:Nitriles; D010641:Phenotype; D011724:Pyridazines / Q000627:therapeutic use*; D011743:Pyrimidines; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use*; D017211:Treatment Failure
chemical_list: D019380:Anti-HIV Agents; D009570:Nitriles; D011724:Pyridazines; D011743:Pyrimidines; D018894:Reverse Transcriptase Inhibitors; C451734:etravirine