Notch-regulated perineurium development from zebrafish spinal cord.
In the developing central nervous system, nerve fascicles are surrounded by a protective sheath known as the perineurium. Perineurium is composed of perineurial cells that have both epithelial and myofibroblastoid properties, including tight and gap junctions and contractility. However, the molecular mechanism that governs perineurial development remains unclear. Here we focused on fabp7a, a brain lipid binding protein that is reportedly crucial for the proper differentiation of radial glial progenitor cells. Our study reveals that fabp7a is expressed in the lateral floor plate cells, and later perineurial glia in the spinal cord of zebrafish embryos. Furthermore, Notch signaling regulated perineurial glia development by maintaining fabp7a-expressing cells, demonstrating a novel mechanism for perineurial development.
Kim
Ho
H
Graduate School of Medicine, Korea University, Ansan, Gyeonggido 425-707, Republic of Korea.
Kim
Suhyun
S
Chung
Ah-Young
AY
Bae
Young-Ki
YK
Hibi
Masahiko
M
Lim
Chae Seung
CS
Park
Hae-Chul
HC
D000818:Animals; D000963:Antimetabolites; D001973:Bromodeoxyuridine; D004625:Embryo, Nonmammalian; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins / Q000096:biosynthesis / Q000235:genetics; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D007814:Larva; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000235:genetics; D009457:Neuroglia / Q000502:physiology; D010525:Peripheral Nerves / Q000196:embryology*; D051880:Receptors, Notch / Q000502:physiology*; D013116:Spinal Cord / Q000196:embryology*; D014280:Triglycerides; D015027:Zebrafish / Q000502:physiology*; D029961:Zebrafish Proteins / Q000096:biosynthesis / Q000235:genetics; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives
D000963:Antimetabolites; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D009419:Nerve Tissue Proteins; D051880:Receptors, Notch; D014280:Triglycerides; D029961:Zebrafish Proteins; C490175:fabp7a protein, zebrafish; D005680:gamma-Aminobutyric Acid; C057077:1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol; D001973:Bromodeoxyuridine