Milligram determination of primary amides.
An accurate and selective milligram procedure for the determination of primary amides is described. About 3-4 mg of sample are hydrolysed with a concentrated solution of sodium hydroxide and the resulting ammonia is distilled into dilute sulphuric acid. The ammonium sulphate thus obtained is converted into ammonium iodide by passing it through hydroxide- and iodide-form resins. This iodide is oxidised to iodate with bromine, then titrated iodometrically. Determinations carried out on a number of primary amides, ureas and thioureas show a deviation of about 0.3% from full recovery of the compounds.
Tiwari
R D
RD
Department of Chemistry, University of Allahabad, Allahabad, India.
Sharma
J P
JP
Shukla
I C
IC