Phenolic glycosides and pyrrolidine alkaloids from Codonopsis tangshen.
Chemical examination of the n-butanol extract of the root of Codonopsis tangshen led to the isolation of four new compounds named codonosides A (1) and B (2) and codonopyrrolidiums A (3) and B (4), with seven known compounds [(Z)-2-(beta-glucopyranosyloxy)-3-phenylpropenoic acid (5), lobetyolin (6), lobetyol (7), luteolin (8), friedelin (9), 5,6,9-trihydroxy-octadec-7-enoic acid (10), and adenosine (11)]. Based on spectroscopic evidence, the structures of codonosides A (1) and B (2) were established as phenolic glycosides, and those of codonopyrrolidiums A (3) and B (4) as pyrrolidines. The relative configuration of 3 was determined by X-ray crystallographic analysis.
Tsai
Tung-Hu
TH
Institute of Traditional Medicine, National Yang-Ming University, Taipei, Taiwan.
Lin
Lie-Chwen
LC
D000470:Alkaloids / Q000032:analysis*; D002240:Carbohydrate Sequence; D002851:Chromatography, High Pressure Liquid; D029745:Codonopsis / Q000737:chemistry*; D006027:Glycosides / Q000032:analysis; D008969:Molecular Sequence Data; D010636:Phenols / Q000032:analysis*; D018517:Plant Roots / Q000737:chemistry; D011759:Pyrrolidines / Q000032:analysis; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014961:X-Ray Diffraction
D000470:Alkaloids; D006027:Glycosides; D010636:Phenols; D011759:Pyrrolidines