Progression of non-culprit coronary artery atherosclerosis after acute myocardial infarction in comparison with stable angina pectoris.
OBJECTIVE
We previously found, using a mouse model, that activation of proinflammatory cytokines after acute myocardial infarction (AMI) augments neointimal hyperplasia of a remote artery. The present study assessed the progression of luminal narrowing of non-culprit coronary arteries (NCCA) in patients following AMI.


METHODS
The study group comprised 21 AMI patients successfully treated with bare-metal stents and 16 stable angina (SA) patients treated with sirolimus-eluting stents. Clinical backgrounds were similar for both groups. Quantitative coronary angiography was performed before and after stent implantation and at 6-months of follow-up.


RESULTS
We evaluated 126 non-culprit coronary segments (73 in AMI and 53 in SA). The minimum lumen diameter (MLD) (mm) of NCCA decreased significantly from 2.61+/-0.79 to 2.44+/-0.71 in the AMI group, but changed only slightly from 2.02+/-0.56 to 2.02+/-0.50 in the SA group. The absolute change in the MLD of NCCA was significantly greater (0.17+/-0.53) in the AMI, than in the SA (0.0070+/-0.261) group.


CONCLUSIONS
luminal narrowing of non-culprit coronary segments progressed in AMI patients within 6 months of stent implantation, but progressed only slightly in SA patients.
Okayama
Satoshi
S
First Department of Internal Medicine, Nara Medical University, Nara, Japan.
Uemura
Shiro
S
Nishida
Taku
T
Morikawa
Yoshinobu
Y
Onoue
Kenji
K
Takemoto
Yasuhiro
Y
Soeda
Tsunenari
T
Somekawa
Satoshi
S
Ishigami
Ken-ichi
K
Takeda
Yukiji
Y
Horii
Manabu
M
Kawata
Hiroyuki
H
Takaoka
Minoru
M
Nakajima
Tamio
T
Saito
Yoshihiko
Y
D000368:Aged; D000787:Angina Pectoris / Q000473:pathology* / Q000628:therapy; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000473:pathology* / Q000628:therapy; D018450:Disease Progression; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction; D015607:Stents; D016896:Treatment Outcome