Effects of nattokinase on blood pressure: a randomized, controlled trial.
The objective of this study was to examine the effects of nattokinase supplementation on blood pressure in subjects with pre-hypertension or stage 1 hypertension. In a randomized, double-blind, placebo-controlled trial, 86 participants ranging from 20 to 80 years of age with an initial untreated systolic blood pressure (SBP) of 130 to 159 mmHg received nattokinase (2,000 FU/capsule) or a placebo capsule for 8 weeks. Seventy-three subjects completed the protocol. Compared with the control group, the net changes in SBP and diastolic blood pressure (DBP) were -5.55 mmHg (95% confidence interval [CI], -10.5 to -0.57 mmHg; p<0.05) and -2.84 mmHg (CI, -5.33 to -0.33 mmHg; p<0.05), respectively, after the 8-week intervention. The corresponding net change in renin activity was -1.17 ng/mL/h for the nattokinase group compared with the control group (p<0.05). In conclusion, nattokinase supplementation resulted in a reduction in SBP and DBP. These findings suggest that increased intake of nattokinase may play an important role in preventing and treating hypertension.
Kim
Ji Young
JY
Yonsei University Research Institute of Science for Aging, Department of Food and Nutrition, College of Human Ecology, Yonsei University, and Department of Family Medicine, Mizmedi Hospital, Seoul, Korea.
Gum
Si Nae
SN
Paik
Jean Kyung
JK
Lim
Hyo Hee
HH
Kim
Kyong-Chol
KC
Ogasawara
Kazuya
K
Inoue
Kenichi
K
Park
Sungha
S
Jang
Yangsoo
Y
Lee
Jong Ho
JH
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000178:diet therapy*; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D010919:Placebos; D012083:Renin / Q000097:blood; D045730:Soy Foods; D013381:Subtilisins / Q000008:administration & dosage*; D016896:Treatment Outcome
D010919:Placebos; D007703:Peptidyl-Dipeptidase A; D013381:Subtilisins; D012083:Renin; C053771:nattokinase