Lung cancer susceptibility locus at 5p15.33.
We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159 controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated disease markers at 5p15.33, rs402710 and rs2736100 were detected by the genome-wide data (P = 2 x 10(-7) and P = 4 x 10(-6)) and replicated by the independent study series (P = 7 x 10(-5) and P = 0.016). The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology.
McKay
James D
JD
International Agency for Research on Cancer (IARC), Lyon, France.
Hung
Rayjean J
RJ
Gaborieau
Valerie
V
Boffetta
Paolo
P
Chabrier
Amelie
A
Byrnes
Graham
G
Zaridze
David
D
Mukeria
Anush
A
Szeszenia-Dabrowska
Neonilia
N
Lissowska
Jolanta
J
Rudnai
Peter
P
Fabianova
Eleonora
E
Mates
Dana
D
Bencko
Vladimir
V
Foretova
Lenka
L
Janout
Vladimir
V
McLaughlin
John
J
Shepherd
Frances
F
Montpetit
Alexandre
A
Narod
Steven
S
Krokan
Hans E
HE
Skorpen
Frank
F
Elvestad
Maiken Bratt
MB
Vatten
Lars
L
Njølstad
Inger
I
Axelsson
Tomas
T
Chen
Chu
C
Goodman
Gary
G
Barnett
Matt
M
Loomis
Melissa M
MM
Lubiñski
Jan
J
Matyjasik
Joanna
J
Lener
Marcin
M
Oszutowska
Dorota
D
Field
John
J
Liloglou
Triantafillos
T
Xinarianos
George
G
Cassidy
Adrian
A
Vineis
Paolo
P
Clavel-Chapelon
Francoise
F
Palli
Domenico
D
Tumino
Rosario
R
Krogh
Vittorio
V
Panico
Salvatore
S
González
Carlos A
CA
Ramón Quirós
José
J
Martínez
Carmen
C
Navarro
Carmen
C
Ardanaz
Eva
E
Larrañaga
Nerea
N
Kham
Kay Tee
KT
Key
Timothy
T
Bueno-de-Mesquita
H Bas
HB
Peeters
Petra Hm
PH
Trichopoulou
Antonia
A
Linseisen
Jakob
J
Boeing
Heiner
H
Hallmans
Göran
G
Overvad
Kim
K
Tjønneland
Anne
A
Kumle
Merethe
M
Riboli
Elio
E
Zelenika
Diana
D
Boland
Anne
A
Delepine
Marc
M
Foglio
Mario
M
Lechner
Doris
D
Matsuda
Fumihiko
F
Blanche
Helene
H
Gut
Ivo
I
Heath
Simon
S
Lathrop
Mark
M
Brennan
Paul
P
D017209:Apoptosis; D016022:Case-Control Studies; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008565:Membrane Proteins / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics*; D025341:Principal Component Analysis; D012907:Smoking; D019098:Telomerase / Q000235:genetics*
C422445:CLPTM1L protein, human; D008565:Membrane Proteins; D009363:Neoplasm Proteins; C509186:TERT protein, human; D019098:Telomerase