Kinetic determination of cephalexin in drug formulations.
A kinetic method for the accurate determination of cephalexin has been described. A solution of cephalexin is reacted with 5 x 10(-3)M cobalt(II) nitrate in 1 x 10(-3)M sodium hydroxide at 60 degrees C for a fixed time of 6 min, after which the absorbance of the reaction product is measured at 310 nm. The concentration of cephalexin is calculated by using the corresponding calibration equation for the fixed-time method. The method has been applied to proprietary drugs and the results were compared statistically with those given by the BP method. The determination of cephalexin by the fixed-concentration and rate-constant methods is feasible with the calibration equations obtained but the fixed-time method has been found to be more applicable.
Alwarthan
A A
AA
Chemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh-11451, Saudi Arabia.
Al-Lohedan
H A
HA