title: Acute exacerbation of subclinical idiopathic pulmonary fibrosis triggered by hypofractionated stereotactic body radiotherapy in a patient with primary lung cancer and slightly focal honeycombing.
abstract: Hypofractionated stereotactic body radiotherapy (SBRT) for pulmonary lesions provides a high local control rate, allows completely painless ambulatory treatment, and is not associated with adverse reactions in most cases. Here we report a 70-year-old lung cancer patient with slight focal pulmonary honeycombing in whom subclinical idiopathic pulmonary fibrosis was exacerbated by SBRT. This experience has important implications for the development of selection criteria prior to SBRT for pulmonary lesions. For SBRT candidates with lung tumors, attention must be paid to the presence of co-morbid interstitial pneumonia even if findings are minimal. Such patients must be informed of potential risks, and careful decision-making must take place when SBRT is being considered.
authors.affiliation: Department of Radiology, Ofuna Chuo Hospital, Kamakura, Japan.
authors.forename: Atsuya
authors.initials: A
authors.lastname: Takeda
authors.forename: Tatsuji
authors.initials: T
authors.lastname: Enomoto
authors.forename: Naoko
authors.initials: N
authors.lastname: Sanuki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nakajima
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Takeda
authors.forename: Koichi
authors.initials: K
authors.lastname: Sayama
authors.forename: Etsuo
authors.initials: E
authors.lastname: Kunieda
mesh_terms: D000368:Aged; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000209:etiology*; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D011859:Radiography; D016634:Radiosurgery / Q000009:adverse effects* / Q000379:methods; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone