Cerebral venous thrombosis associated with iron deficiency anemia.
A 55-year-old man presented with generalized seizures and postictal left hemiparesis. Computed tomography scanning of his head showed a low density area in the right frontal lobe. Cerebral angiography demonstrated a partial defect in the superior sagittal sinus and cortical veins, indicating the presence of cerebral venous thrombosis. He had bleeding from a peptic ulcer and the laboratory data revealed iron deficiency anemia concomitant with an elevation of D-dimer and thrombin-antithrombin III complex (TAT). After the anemia resolved with the treatment of the peptic ulcer and iron supplementation, the TAT and D-dimer levels were normalized, and the occluded veins were recanalized. In a cerebral venous thrombosis associated with iron deficiency anemia, treatment for the anemia may improve hypercoagulable state without antithrombotic therapy, although the long-term monitoring of TAT and D-dimer levels is required.
Ogata
Toshiyasu
T
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kamouchi
Masahiro
M
Kitazono
Takanari
T
Kuroda
Junya
J
Ooboshi
Hiroaki
H
Shono
Tadahisa
T
Morioka
Takato
T
Ibayashi
Setsuro
S
Sasaki
Tomio
T
Iida
Mitsuo
M
D018798:Anemia, Iron-Deficiency / Q000150:complications* / Q000503:physiopathology; D000990:Antithrombin III; D001778:Blood Coagulation Disorders / Q000150:complications / Q000209:etiology / Q000503:physiopathology; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D002533:Cerebral Angiography; D002550:Cerebral Veins / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D019587:Dietary Supplements; D006801:Humans; D007501:Iron / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010291:Paresis / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology; D010437:Peptic Ulcer / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D010447:Peptide Hydrolases / Q000097:blood; D012640:Seizures / Q000209:etiology / Q000503:physiopathology; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000209:etiology* / Q000473:pathology* / Q000503:physiopathology
C046193:antithrombin III-protease complex; D000990:Antithrombin III; D007501:Iron; D010447:Peptide Hydrolases