2-Iodylbenzoic acid as an oxidizing agent for the determination of certain thioxanthene derivatives.
An indirect titrimetric method is described for the determination of chlorprothixene, methixene and thiothixene. A known and excessive volume of 2-iodylbenzoate is added and after a specified time the surplus is determined iodometrically. The method has been applied to the analysis of pharmaceutical preparations containing these drugs and the results obtained compare favourably with those from the pharmacopoeial methods. The method is simple, accurate and precise.
El-Brashy
A M
AM
Department of Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.