title: [Salivary gland damage after 131I therapy in patients with differentiated thyroid cancer. Preliminary report].
abstract: BACKGROUND
  The purpose of the study was to evaluate salivary gland dysfunction after a high-dose radioiodine therapy administered to patients with differentiated thyroid carcinoma.
  
  
  METHODS
  The study group consisted of 60 patients (age range 20-78 years). Detailed history about complaints from the oral cavity were taken, followed by the ultrasonography and dynamic scintigraphy. The procedure was performed on 40 patients before and one year after radioiodine administration, and a single-time on 20 patients treated with multiple doses in the past.
  
  
  RESULTS
  Data analysis shows no statistically significant increase of subjective sufferings after first radioiodine dose (60-150 mCi), small decrease of uptake ratio UR (< 10%) and diminished parotid glands transverse diameter (approximately 10%). The patients after multiple therapies (i.e. average dose of 250 mCi) informed more often about problems connected with decreased salivation (approximately 20% patients), in scintigraphy there was a reduction of parotid UR 21-23% and parotid maximal secretion MS 7-13%. Ultrasonography did not show changes in salivary glands echogenicity after 12 months from the first dose of 131I. There was no close relationship between scintigraphically revealed dysfunctions and the occurrence of complaints; no correlation between appearance of acute sialadenitis symptoms after radioiodine therapy and subsequent dysfunctions.
  
  
  CONCLUSIONS
  The main conclusion is that a single dose of 131I has no significant influence on salivary gland function; a repeated high-doses therapy is connected with an essential risk of side-effect occurrence. Scintigraphy can evaluate salivary gland function with high sensitivity. Parotid glands are more radiosensitive than submandibular.
authors.affiliation: Pracownia Medycyny Nuklearnej, Katedra i Klinika Endokrynologii, Przemiany Materii i Chorób Wewnetrznych, Pozań. humerus@go2.pl
authors.forename: Adam
authors.initials: A
authors.lastname: Macioszek
authors.forename: Maciej
authors.initials: M
authors.lastname: Baczyk
authors.forename: Tomasz
authors.initials: T
authors.lastname: Kopeć
authors.forename: Jerzy
authors.initials: J
authors.lastname: Sowiński
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010306:Parotid Gland / Q000528:radiation effects; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000175:diagnosis / Q000209:etiology*; D012469:Salivary Glands / Q000528:radiation effects*; D012793:Sialadenitis / Q000175:diagnosis / Q000209:etiology; D013363:Submandibular Gland / Q000187:drug effects; D013964:Thyroid Neoplasms / Q000532:radiotherapy*
chemical_list: D007457:Iodine Radioisotopes