[Comparative analysis of sensitivity of cholinesterase inhibitors by multidimensional statistical methods].
Using the methods of factor and cluster analysis, the statistical treatment is performed of data on interaction of 7 cholinesterases (ChE)--human acetylcholinesterase, horse butyrylcholinesterase, cholinesterases of frog brain and of various squid species (Todarodes pacificus and Berrytheutis magister; in the latter case, individuals from three different habitats are compared)--with 141 reversible inhibitors of various structures. Statistically significant differences between ChE of squids and vertebrates are shown. The previously revealed intraspecies peculiarities of ChE in the Commander squid B. magister are statistically confirmed.
Moralev
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Perchenok
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AIu
D000110:Acetylcholinesterase / Q000737:chemistry; D000818:Animals; D002091:Butyrylcholinesterase / Q000737:chemistry; D002800:Cholinesterase Inhibitors / Q000737:chemistry*; D002802:Cholinesterases / Q000737:chemistry*; D016000:Cluster Analysis; D049832:Decapodiformes; D006736:Horses; D006801:Humans; D015233:Models, Statistical; D011896:Rana temporaria; D013329:Structure-Activity Relationship
D002800:Cholinesterase Inhibitors; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase; D002802:Cholinesterases