title: Integration of positron emission tomography/computed tomography with electroanatomical mapping: a novel approach for ablation of scar-related ventricular tachycardia.
abstract: BACKGROUND
  Despite the recent advances in cardiac mapping, ablation of scar-related ventricular tachycardia (VT) still remains a clinical challenge. A detailed electroanatomical map is a prerequisite for accurate localization and ablation of the VT substrate.
  
  
  OBJECTIVE
  The purpose of this study was to evaluate the feasibility and accuracy of integrating the positron emission tomography (PET)/computed tomography (CT) with the electroanatomical map and compare the accuracy of the voltage-based scar with the biological scar.
  
  
  METHODS
  Patients undergoing radiofrequency ablation (n = 19) for scar-related VT were enrolled. CT angiography and PET scans were performed for all patients. Tomographic and volumetric data from both images were processed and coregistered using internally designed software. That image was segmented in an electrophysiology mapping system and registered to the electroanatomical map. Eight different thresholds were applied on the voltage map to define the scar. The surface areas of the biological and electrical dense scars at different thresholds were measured and compared.
  
  
  RESULTS
  The PET/CT image was well integrated with the electroanatomical map with a mean surface registration error of 5.1 +/- 2.1 mm. Of the eight different thresholds defining the scar, the surface area of the scar at a threshold of 0.9 mV (68.6 +/- 49.2 cm(2)) correlated best with the surface area of the PET-based scar (70.4 +/- 49.3 cm(2)) and had the least total area error (4.8 +/- 1.8 cm(2)) compared with the 0.5 threshold (29.7 +/- 23.9 cm(2)).
  
  
  CONCLUSIONS
  Integrating PET/CT with the electroanatomical map is feasible and accurate. Based on the biological scar, readjustment of the voltage scar threshold to 0.9 mV is suggested. In view of the better accuracy of PET/CT in defining scar, the need for acquiring detailed voltage maps may be obviated.
authors.affiliation: Department of Cardiovascular Medicine, Cleveland Clinic, Ohio, USA.
authors.forename: Tamer S
authors.initials: TS
authors.lastname: Fahmy
authors.forename: Oussama M
authors.initials: OM
authors.lastname: Wazni
authors.forename: Wael A
authors.initials: WA
authors.lastname: Jaber
authors.forename: Vivek
authors.initials: V
authors.lastname: Walimbe
authors.forename: Luigi
authors.initials: L
authors.lastname: Di Biase
authors.forename: Claude S
authors.initials: CS
authors.lastname: Elayi
authors.forename: Frank P
authors.initials: FP
authors.lastname: DiFilippo
authors.forename: Ron B
authors.initials: RB
authors.lastname: Young
authors.forename: Dimpi
authors.initials: D
authors.lastname: Patel
authors.forename: Lucie
authors.initials: L
authors.lastname: Riedlbauchova
authors.forename: Andrea
authors.initials: A
authors.lastname: Corrado
authors.forename: J David
authors.initials: JD
authors.lastname: Burkhardt
authors.forename: Robert A
authors.initials: RA
authors.lastname: Schweikert
authors.forename: Mauricio
authors.initials: M
authors.lastname: Arruda
authors.forename: Andrea
authors.initials: A
authors.lastname: Natale
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018780:Body Surface Potential Mapping; D017115:Catheter Ablation; D002921:Cicatrix / Q000209:etiology*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications*; D049268:Positron-Emission Tomography; D017180:Tachycardia, Ventricular / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery*; D014057:Tomography, X-Ray Computed