title: Influence of previously ingested wheat on fasting breath hydrogen in celiac patients.
abstract: The excretion of hydrogen in breath commonly persists, despite an overnight fast. Although the elevation of hydrogen concentration above the fasting value after the administration of a test sugar is evidence of malabsorption, the level of the fasting value itself in untreated celiac patients is unknown. Therefore, we studied the fasting breath hydrogen (FBH(2)) concentration in 40 healthy controls, 35 subjects with functional bowel disorders, and 30 patients of untreated celiac disease with and without bread or wheat diet one day before the test. The fasting level of hydrogen concentration in untreated celiac patients (28.7 +/- 19.5 ppm) was significantly higher than those in healthy volunteers (9.5 +/- 3.4 ppm) and subjects with functional bowel disorders (10.6 +/- 4.5 ppm). The percentage of patients with elevated H(2) fasting levels in untreated celiac disease (82.5%) was significantly higher than that in healthy controls (10%) and subjects with functional bowel disorders (17.1%). In 30 celiac patients, studied with and without wheat-free diet one day before the test, the fasting hydrogen levels decreased from 28.7 +/- 19.5 ppm to 10.6 +/- 3.5 ppm, and becoming normal in all patients of celiac disease. Our results show that the patients of untreated celiac disease should be instructed not to eat things made up of wheat one day before hydrogen breath testing so that the normal fasting hydrogen concentration can be obtained and false-negative hydrogen breath test results can be avoided.
authors.affiliation: Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. svrana25@hotmail.com
authors.forename: S V
authors.initials: SV
authors.lastname: Rana
authors.forename: S
authors.initials: S
authors.lastname: Sharma
authors.forename: S K
authors.initials: SK
authors.lastname: Sinha
authors.forename: J
authors.initials: J
authors.lastname: Kaur
authors.forename: K K
authors.initials: KK
authors.lastname: Prasad
authors.forename: K
authors.initials: K
authors.lastname: Singh
mesh_terms: D000293:Adolescent; D000328:Adult; D001944:Breath Tests; D002446:Celiac Disease / Q000378:metabolism*; D004040:Dietary Carbohydrates / Q000378:metabolism; D005215:Fasting; D005260:Female; D005983:Glutens / Q000008:administration & dosage; D006801:Humans; D006859:Hydrogen / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D014908:Triticum; D055815:Young Adult
chemical_list: D004040:Dietary Carbohydrates; D006859:Hydrogen; D005983:Glutens