Evidence of reduced glutamate in the frontal lobe of HIV-seropositive patients.
Neurological complications associated with the acquired immunodeficiency syndrome, in particular, HIV-associated dementia, continue to plague those infected. We report our finding that the concentration of brain Glu is reduced in the frontal white matter region in this condition. In addition, our data appear to absolve highly active retroviral therapy (HAART) from blame, as drug-naïve patients were equally affected. Our findings suggest that Glu neurotransmission is abnormal and may be a key target for early interventions to reduce the later incidence of neurocognitive impairment and dementia among HIV-seropositive patients.
Sailasuta
Napapon
N
Huntington Medical Research Institutes, Pasadena, CA, USA. Sailasuta@hmri.org
Shriner
Kimberly
K
Ross
Brian
B
D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D005625:Frontal Lobe / Q000378:metabolism* / Q000821:virology*; D018698:Glutamic Acid / Q000378:metabolism*; D006679:HIV Seropositivity / Q000378:metabolism*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged
D001224:Aspartic Acid; D018698:Glutamic Acid; C000179:N-acetylaspartate