title: Whole-body magnetic resonance imaging for detecting bone metastases: comparison with bone scintigraphy.
abstract: OBJECTIVE
  The aim of the study was to assess the reliability of whole-body magnetic resonance imaging (WB-MRI) in detecting skeletal metastasis and to compare the results with those of bone scintigraphy (BS).
  
  
  METHODS
  Thirty-three patients (21 women, 12 men, median age 58 years, range 27-78) were enrolled. Histological proof of malignancy was obtained in all cases. The primary tumour was unknown in 1 patient. BS and WB-MRI were performed as staging procedures in 15 patients, during the follow-up in 6 and to investigate pain in 9 and neurological symptoms in 3. Bone metastases were recorded for 8 different skeletal segments (ribs, skull, cervicothoracic spine, lumbosacral spine, clavicle-scapula-sternum, pelvis, upper extremities and lower extremities) in all patients, for a total of 264 examined areas.
  
  
  RESULTS
  Bone metastases were detected in 18 patients (55%). In 15/33 patients, WB-MRI and BS were concordantly negative. BS revealed focal metastatic uptake in 72%, whereas WB-MRI was positive in 89%. Results differed in seven patients. WB-MRI was positive but BS was negative in five cases. Two patients with negative WB-MRI had focal and intense uptake in the ribs on BS. Out of 264 examined areas, bone metastases were detected in 34 (13%). WB-MRI revealed tumour spread in 26/34 areas (76%) and BS in 21/34 areas only (62%).
  
  
  CONCLUSIONS
  WB-MRI is a reliable method for screening patients with suspected skeletal metastases, although BS still remains a useful tool. WB-MRI is also advantageous because it reveals extraskeletal and soft tissue metastases.
authors.affiliation: U.O.C. e Cattedra di Medicina Nucleare, Viale Europa 88100, Catanzaro, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Cascini
authors.forename: C
authors.initials: C
authors.lastname: Falcone
authors.forename: C
authors.initials: C
authors.lastname: Greco
authors.forename: B
authors.initials: B
authors.lastname: Bertucci
authors.forename: S
authors.initials: S
authors.lastname: Cipullo
authors.forename: O
authors.initials: O
authors.lastname: Tamburrini
mesh_terms: D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000556:secondary*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D015203:Reproducibility of Results