title: Successful treatment of disseminated Acanthamoeba sp. infection with miltefosine.
abstract: We report on an HIV-negative but immunocompromised patient with disseminated acanthamoebiasis, granulomatous, amoebic encephalitis and underlying miliary tuberculosis and tuberculous meningitis. The patient responded favorably to treatment with miltefosine, an alkylphosphocholine. The patient remained well with no signs of infection 2 years after treatment cessation.
authors.affiliation: Pulmonological Centre, Otto Wagner Hospital, Vienna, Austria. alexander.aichelburg@wienkav.at
authors.forename: Alexander C
authors.initials: AC
authors.lastname: Aichelburg
authors.forename: Julia
authors.initials: J
authors.lastname: Walochnik
authors.forename: Ojan
authors.initials: O
authors.lastname: Assadian
authors.forename: Helmut
authors.initials: H
authors.lastname: Prosch
authors.forename: Andrea
authors.initials: A
authors.lastname: Steuer
authors.forename: Gedeon
authors.initials: G
authors.lastname: Perneczky
authors.forename: Govinda S
authors.initials: GS
authors.lastname: Visvesvara
authors.forename: Horst
authors.initials: H
authors.lastname: Aspöck
authors.forename: Norbert
authors.initials: N
authors.lastname: Vetter
mesh_terms: D000048:Acanthamoeba; D000284:Administration, Oral; D000287:Administration, Topical; D000328:Adult; D000562:Amebiasis / Q000150:complications / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004660:Encephalitis / Q000150:complications / Q000276:immunology / Q000473:pathology; D006099:Granuloma / Q000150:complications / Q000276:immunology / Q000473:pathology; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D010767:Phosphorylcholine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012883:Skin Ulcer / Q000150:complications / Q000276:immunology / Q000473:pathology; D016896:Treatment Outcome; D014391:Tuberculosis, Miliary / Q000150:complications / Q000276:immunology / Q000473:pathology
chemical_list: D000981:Antiprotozoal Agents; D010767:Phosphorylcholine; C039128:miltefosine