Alkali metals in silica gel (M-SG): a new reagent for desulfonation of amines.
A novel method for the desulfonation of secondary amines is described. Alkali metals absorbed into nanostructured silica (M-SG) were found to be useful solid-state reagents for the desulfonation of a range of N,N-disubstituted sulfonamides. M-SG reagents are room-temperature-stable free-flowing powders that retain the chemical reactivity of the parent metal, decreasing the danger and associated cost of using reactive metals.
Nandi
Partha
P
Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA.
Redko
Mikhail Y
MY
Petersen
Kathryn
K
Dye
James L
JL
Lefenfeld
Michael
M
Vogt
Paul F
PF
Jackson
James E
JE
D000588:Amines / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry; D008672:Metals, Alkali / Q000737:chemistry*; D058428:Silica Gel; D012822:Silicon Dioxide / Q000737:chemistry*; D013449:Sulfonamides / Q000737:chemistry; D013451:Sulfonic Acids / Q000737:chemistry*
D000588:Amines; D007202:Indicators and Reagents; D008672:Metals, Alkali; D013449:Sulfonamides; D013451:Sulfonic Acids; D058428:Silica Gel; D012822:Silicon Dioxide