title: Comparison of bioabsorbable materials for use in artificial tracheal grafts.
abstract: Limited information exists regarding the usefulness of bioabsorbable materials in the design of tracheal grafts. The aim of this study was to evaluate the feasibility of three bioabsorbable materials for use as artificial trachea. Three sets of grafts were prepared: Group 1 (n=6), knitted polyglactin 910 mesh; Group 2 (n=3), copolymer of L-lactide and epsilon-caprolactone sponge reinforced with polyglycoride fibers; and Group 3 (n=8), copolymer of L-lactide and epsilon-caprolactone sponge covered with knitted poly-L-lactide mesh. All grafts were internally reinforced with a titanium stent. A 10-cartilage-ring-length of canine mediastinal trachea was resected and replaced by a bioabsorbable prosthesis with the aid of an omental flap. In Groups 1 and 2, the patency rates decreased below 50% within two months after surgery. In Group 3, six of eight dogs maintained patency rates above 50% from 10 months to 2 years after surgery. Grafts prepared with a copolymer of L-lactide and epsilon-caprolactone sponge covered with knitted poly-l-lactide mesh (Group 3) can function for up to two years after surgery. These results provide evidence toward the feasibility of utilizing bioabsorbable materials as a tracheal prosthesis.
authors.affiliation: Department of Surgery, Division of Chest Surgery, St Marianna University School of Medicine, Kawasaki, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Tsukada
authors.forename: Shojiro
authors.initials: S
authors.lastname: Matsuda
authors.forename: Hajime
authors.initials: H
authors.lastname: Inoue
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Ikada
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Osada
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001999:Bronchoscopy; D004285:Dogs; D005240:Feasibility Studies; D008422:Materials Testing; D009852:Omentum / Q000601:surgery; D011091:Polyesters / Q000737:chemistry; D011098:Polyglactin 910 / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D011474:Prosthesis Design; D011475:Prosthesis Failure; D019919:Prosthesis Implantation / Q000009:adverse effects / Q000295:instrumentation*; D015607:Stents; D013499:Surface Properties; D013524:Surgical Flaps; D013526:Surgical Mesh; D015503:Surgical Sponges; D013997:Time Factors; D014025:Titanium; D014132:Trachea / Q000473:pathology / Q000601:surgery*; D014135:Tracheal Stenosis / Q000209:etiology / Q000517:prevention & control
chemical_list: D011091:Polyesters; D011108:Polymers; D011098:Polyglactin 910; C033616:poly(lactide); C062968:lactide-caprolactone copolymer; D014025:Titanium