title: Iron-catalyzed enyne cross-coupling reaction.
abstract: In the presence of 0.5-1 mol % of FeCl(3) with lithium bromide as a crucial additive, alkynyl Grignard reagents, prepared from the corresponding alkynes and methylmagnesium bromide, react with alkenyl bromides or triflates to give the corresponding conjugated enynes in high to excellent yields. The reaction shows wide applicability to various terminal alkynes and alkenyl electrophiles.
authors.affiliation: International Research Center for Elements Science, Institute for Chemical Research, Kyoto University, Uji, Kyoto, 611-0011, Japan.
authors.forename: Takuji
authors.initials: T
authors.lastname: Hatakeyama
authors.forename: Yuya
authors.initials: Y
authors.lastname: Yoshimoto
authors.forename: Toma
authors.initials: T
authors.lastname: Gabriel
authors.forename: Masaharu
authors.initials: M
authors.lastname: Nakamura
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D001965:Bromides / Q000737:chemistry; D002384:Catalysis; D007202:Indicators and Reagents / Q000737:chemistry; D007501:Iron / Q000737:chemistry*; D020058:Styrene / Q000737:chemistry
chemical_list: D000475:Alkenes; D000480:Alkynes; D001965:Bromides; D007202:Indicators and Reagents; D020058:Styrene; D007501:Iron