Cystatin C for early detection of renal impairment in diabetes.
OBJECTIVE
Evaluation of glomerular filtration rate is of crucial importance in diabetes. Cystatin C, a cysteine protease inhibitor seems to be an interesting parameter.


METHODS
67 diabetic patients with normal creatinine are evaluated. Cystatin C is compared to renal markers, by reference to Cr EDTA clearance.


RESULTS
Significant correlations are found between cystatin C and creatinine (r=0.54). GFR MDRD (r=-0.47) and GFR Cr EDTA (r=-0.47). The AUC of the receiver operating curves is better for GFR MDRD (0.83) and cystatin C (0.75) than for creatinine (0.63) considering the cut off value of 80 mL/min for GFR EDTA.


CONCLUSIONS
Cystatin C seems to be a more sensitive parameter than creatinine for the detection of an incipient nephropathy in diabetes.
Willems
D
D
Clinical Chemistry and Diabetology Unit, Brugmann University Hospital, Brussels, Belgium. Dominique.willems@chu-brugmann.be
Wolff
F
F
Mekahli
F
F
Mekhali
F
F
Gillet
C
C
D000328:Adult; D000368:Aged; D055316:Cystatin C / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D003928:Diabetic Nephropathies / Q000097:blood / Q000175:diagnosis*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged
D055316:Cystatin C