title: Close examination of steroidogenesis disorders in a DOC- and progesterone-producing adrenocortical carcinoma.
abstract: We report a case of hypertension, hypokalemia, and amenorrhea accompanying an adrenocortical carcinoma. A 27-year-old woman was admitted to our hospital because of a left adrenal incidentaloma. She presented with hypertension, hypokalemia, and amenorrhea; her plasma renin activity was low, but her plasma aldosterone concentration was normal, as were cortisol and androgens. By contrast, her serum concentrations of deoxycorticosterone (DOC), 18-hydroxydeoxycorticosterone, and progesterone were high, and her urinary steroid profile showed elevated secretion of 17-deoxysteroids and 11-deoxysteroids (progesterone, DOC, 11-dehydrocorticosterone, and 11-deoxycortisol), and 3beta-hydroxy 5-en steroids (pregnenolone, 17-hydroxypregnenolone, and DHEA). Decreased ratios of metabolites of (1) 17-OHpregnenolone to pregnenolone and 17-OHprogesterone to progesterone, (2) corticosterone to DOC and cortisol to 11-deoxycortisol, and (3) progesterone to pregnenolone, 17-OHprogesterone to 17-OHpregnenolone and androstenedione to DHEA suggested the impairment of 17alpha-hydroxylase, 11beta-hydroxylase, and 3beta-HSD activities, respectively. After the tumor was removed, levels of all adrenal steroids were normalized. Based on the Weiss criteria, the tumor was diagnosed as an adrenocortical carcinoma, and immunohistochemical analysis of steroidogenic enzymes revealed disorganized steroidogenesis in the tumor tissue. With adrenocortical carcinomas, heterogeneity of individual steroid producing enzymes within tumor cells can lead to hypersecretion of various steroid intermediates, even when steroid end products are within the normal range.
authors.affiliation: Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, 606-8507, Japan. sonemasa@kuhp.kyoto-u.ac.jp
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Sone
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Shibata
authors.forename: Keiko
authors.initials: K
authors.lastname: Homma
authors.forename: Naohisa
authors.initials: N
authors.lastname: Tamura
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Akahira
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hamada
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Yahata
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Fukui
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Itoh
authors.forename: Hironobu
authors.initials: H
authors.lastname: Sasano
authors.forename: Kazuwa
authors.initials: K
authors.lastname: Nakao
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D018268:Adrenocortical Carcinoma / Q000175:diagnosis* / Q000378:metabolism; D000328:Adult; D003900:Desoxycorticosterone / Q000378:metabolism*; D004700:Endocrine System Diseases / Q000209:etiology* / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis; D033162:Incidental Findings; D008954:Models, Biological; D010808:Physical Examination; D011374:Progesterone / Q000378:metabolism*; D013256:Steroids / Q000096:biosynthesis
chemical_list: D013256:Steroids; D003900:Desoxycorticosterone; D011374:Progesterone