title: Lupane glycosides from the leaves of Acanthopanax koreanum.
abstract: Three new lupane-type saponins, acankoreosides F--H (1--3) were isolated from the methanol extract of the leaves of Acanthopanax koreanum NAKAI. The structures of these three saponins were established by chemical and spectroscopic analysis as 3alpha,30-dihydroxylup-20(29)-en-23,28-dioic acid 28-O-[alpha-L-rhamnopyranosyl-(1-->4)-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl] ester (1), 3alpha,30-dihydroxylup-23-al-20(29)-en-28-oic acid 28-O-[alpha-L-rhamnopyranosyl-(1-->4)-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl] ester (2), and (20S) 3alpha-hydroxylup-23-al-28,29-dioic acid 28-O-[alpha-L-rhamnopyranosyl-(1-->4)-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl] ester (3), respectively. The effects of the isolates (1-3) on the lipopolysaccharide-induced production of nitric oxide and prostaglandin E2 were evaluated in RAW 264.7 macrophages.
authors.affiliation: Kyung Hee East-West Pharmaceutical Research Institute, College of Pharmacy and Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul, Korea.
authors.forename: Hyun-Sik
authors.initials: HS
authors.lastname: Choi
authors.forename: Hyoung Ja
authors.initials: HJ
authors.lastname: Kim
authors.forename: Sang-Gil
authors.initials: SG
authors.lastname: Nam
authors.forename: In-Seon
authors.initials: IS
authors.lastname: Kim
authors.forename: Kyung-Tae
authors.initials: KT
authors.lastname: Lee
authors.forename: Chang-Soo
authors.initials: CS
authors.lastname: Yook
authors.forename: Yong Sup
authors.initials: YS
authors.lastname: Lee
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology; D002240:Carbohydrate Sequence; D015232:Dinoprostone / Q000737:chemistry; D028001:Eleutherococcus / Q000737:chemistry*; D006027:Glycosides / Q000302:isolation & purification* / Q000494:pharmacology; D006868:Hydrolysis; D008264:Macrophages / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D009569:Nitric Oxide / Q000096:biosynthesis; D018515:Plant Leaves / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D006027:Glycosides; D012503:Saponins; D014315:Triterpenes; C534654:acankoreoside F; C534655:acankoreoside G; C534656:acankoreoside H; D009569:Nitric Oxide; D015232:Dinoprostone