title: Coffee consumption and bone mineral density in dialysis patients.
abstract: The influence of ingested coffee on bone mineral density (BMD) and the related risk of pathologic fractures is controversial. We decided to check if dialysis patients drinking coffee may have a BMD different from that of non coffee drinkers. We studied 30 dialysis patients (26 on hemodialysis, 4 on peritoneal dialysis). Group I (n = 11, 5 women) included patients who regularly drank at least 1 cup of coffee daily [dialysis duration: 29.1 months (range: 8.7- 59.6 months); age: 56.0 +/- 14.6 years]. Group II (n = 19, 13 women) consisted of patients who said that they were nondrinkers of coffee [dialysis duration: 15.2 months (range: 6.3 - 45.4 months); age: 56.3 +/- 19.8 years]. We examined BMD in all subjects in two sites (femoral neck and L2 - L4 lumbar region) by dual-energy X-ray absorptiometry. Serum parathyroid hormone, calcium-phosphate balance parameters, blood pH, serum markers of inflammation, bioimpedance records of body composition, and markers of nutrition were simultaneously evaluated. Compared with group II, group I showed significantly lower L2 -L4 parameters: BMD (0.906 +/- 0.236 g/cm2 vs. 1.172 +/- 0.227 g/cm2, p = 0.005), percent of peak BMD (78.4% +/- 18.9% vs. 98.4% +/- 17.0%, p = 0.006), percent of age norm (82.7% +/- 18.2% vs. 105.9% +/- 17.7% p = 0.002), T-score [-2.07 (range: -3.95 to 2.02) vs. -0.51 (range: -2.29 to 4.07), p = 0.020], and Z-score [-1.25 (range: -4.41 to 1.90) vs. 0.26 (range: -1.48 to 4.49), p = 0.006]. Serum albumin concentration was higher in group I [4.0 g/dL (range: 3.1 - 4.3 g/dL) vs. 3.3 g/dL (range: 2.9 - 4.4 g/dL), p = 0.020]. Our results suggest that regular coffee consumption may contribute to BMD loss in dialysis patients.
authors.affiliation: Chair and Department of Nephrology, Transplantology and Internal Diseases, Karol Marcinkowski University of Medical Sciences, Poznań', Poland. alicja_grzegorzewska@yahoo.com
authors.forename: Alicja E
authors.initials: AE
authors.lastname: Grzegorzewska
authors.forename: Monika
authors.initials: M
authors.lastname: Młot-Michalska
mesh_terms: D015519:Bone Density; D003069:Coffee / Q000009:adverse effects*; D005260:Female; D005272:Femur Neck; D006801:Humans; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
chemical_list: D003069:Coffee