Topical antibiotics in dermatology: emerging patterns of resistance.
Resistance to topical antibiotics is increasingly relevant in dermatology. This article discusses emerging patterns of resistance and the implications for clinical practice. Emergence of resistance is complicating decolonization of the skin and nares in patients infected with methicillin-resistant Staphylococcus aureus. In the setting of acne treatment, adding topical benzoyl peroxide has been shown to reduce the emergence of strains resistant to topical antibiotics. Other agents, such as zinc salts, are promising in this regard. This article discusses alternatives to antibiotics and mechanisms to stem the emergence of resistance.
Elston
Dirk M
DM
Department of Dermatology, Geisinger Medical Center, 100 North Academy Avenue, Danville, PA 17821, USA. dmelston@geisinger.edu
D000152:Acne Vulgaris / Q000188:drug therapy*; D000287:Administration, Topical; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D024881:Drug Resistance, Bacterial; D006801:Humans; D013207:Staphylococcal Skin Infections / Q000188:drug therapy*
D000900:Anti-Bacterial Agents