title: Protective effect of DA-9601, an extract ofArtemisiae Herba, against naproxen-induced gastric damage in arthritic rats.
abstract: Gastrointestinal irritation is the most frequent adverse effect in patients chronically taking nonsteroidal antiinflammatory drugs (NSAIDs) for the treatment of arthritic conditions. Gastroprotective effect of DA-9601, a new antiulcer agent fromArtemisiae Herba extract, against NSAID was evaluated in a rat model of arthritis that is similar in many aspects to human rheumatoid arthritis. Daily oral dosing of naproxen (30 mg/kg), one of the most commonly used NSAID, induced apparent gastric lesions as well as a significant decrease in mucosal prostaglandin E(2) (PGE(2)) and prostaglandin F(1alpha) (PGF(1alpha)) levels. Coadministration of DA-9601 prevents naproxen-induced mucosal injury and depletion, of prostaglandins, in a dose-related manner. DA-9601 did not alter the antiinflammatory or analgesic effect of naproxen. The present results suggest that DA-9601 may be useful as a mucoprotectant against NSAIDs in clinical practice.
authors.affiliation: Research Laboratories, Dong-A Pharm. Co. Ltd., 47-5 Sanggalri, Kiheungup, Yonginsi, 449-900, Kyunggido, Korea.
authors.forename: T Y
authors.initials: TY
authors.lastname: Oh
authors.forename: B K
authors.initials: BK
authors.lastname: Ryu
authors.forename: J I
authors.initials: JI
authors.lastname: Ko
authors.forename: B O
authors.initials: BO
authors.lastname: Ahn
authors.forename: S H
authors.initials: SH
authors.lastname: Kim
authors.forename: W B
authors.initials: WB
authors.lastname: Kim
authors.forename: E B
authors.initials: EB
authors.lastname: Lee
authors.forename: J H
authors.initials: JH
authors.lastname: Jin
authors.forename: K B
authors.initials: KB
authors.lastname: Hahm