Aging: ROS or TOR.
It is widely believed that aging is caused by the accumulation of random molecular damage due to reactive oxygen species (ROS). Here I discuss evidence for and against the ROS theory. Remarkably, even supporting evidence has an alternative explanation, consistent with the model that aging is driven by the TOR (target of rapamycin) signaling pathway.
Blagosklonny
Mikhail V
MV
Ordway Research Institute, and Oncotarget, Albany, New York 12208, USA. Blagosklonny@oncotarget.com
D000375:Aging / Q000378:metabolism*; D000818:Animals; D016923:Cell Death; D002986:Clinical Trials as Topic; D006801:Humans; D008954:Models, Biological; D011494:Protein Kinases / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D058570:TOR Serine-Threonine Kinases
D017382:Reactive Oxygen Species; D011494:Protein Kinases; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases