title: Is overcoming hormone resistance in breast cancer possible?
abstract: The administration of hormones plays a major role in the treatment of hormone receptor-expressing breast cancers (BCs), both in the adjuvant setting as well as in advanced disease. Hormone-responsive tumors almost uniformly develop resistance, either independently or as a result of exposure to hormones. Overcoming this phenomenon constitutes a perpetual challenge to researchers and clinical oncologists. Understanding the mechanisms leading to hormone resistance is crucial to its inhibition or, at least, its delayed onset. This manuscript provides a brief review of this topic.
authors.affiliation: Department of Oncology, Nicosia General Hospital, Nicosia, Cyprus. georgeorphanosvp@hotmail.com
authors.forename: G
authors.initials: G
authors.lastname: Orphanos
authors.forename: N
authors.initials: N
authors.lastname: Kakoullou
authors.forename: A
authors.initials: A
authors.lastname: Ardavanis
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000517:prevention & control*; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D009376:Neoplasms, Hormone-Dependent / Q000517:prevention & control*
chemical_list: D018931:Antineoplastic Agents, Hormonal