title: High-speed, high-resolution Fourier-domain optical coherence tomography system for retinal imaging in the 1060 nm wavelength region.
abstract: A high-speed (47,000 A-scans/s), ultrahigh axial resolution Fourier domain optical coherence tomography (OCT) system for retinal imaging at approximately 1060 nm, based on a 1024 pixel linear array, 47 kHz readout rate InGaAs camera is presented. When interfaced with a custom superluminescent diode (lambda(c) = 1020 nm, Deltalambda = 108 nm, Pout = 9 mW), the system provides 3.3 microm axial OCT resolution at the surface of biological tissue, approximately 4.5 microm in vivo in rat retina, approximately 5.7 microm in vivo in human retina, and 110 dB sensitivity for 870 microW incident power and 21 mus integration time. Retinal tomograms acquired in vivo from a human volunteer and a rat animal model show clear visualization of all intraretinal layer and increased penetration into the choroid.
authors.affiliation: Department of Physics and Astronomy, University of Waterloo, Waterloo, Ontario, Canada.
authors.forename: Prabakar
authors.initials: P
authors.lastname: Puvanathasan
authors.forename: Peter
authors.initials: P
authors.lastname: Forbes
authors.forename: Zhao
authors.initials: Z
authors.lastname: Ren
authors.forename: Doug
authors.initials: D
authors.lastname: Malchow
authors.forename: Shelley
authors.initials: S
authors.lastname: Boyd
authors.forename: Kostadinka
authors.initials: K
authors.lastname: Bizheva
mesh_terms: D000818:Animals; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D051381:Rats; D012160:Retina / Q000166:cytology*; D042262:Retinoscopy / Q000379:methods*; D012680:Sensitivity and Specificity; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*; D041623:Tomography, Optical Coherence / Q000379:methods*