Synthesis of novel substituted 7-(benzylideneamino)-4-methyl-2H-chromen-2-one derivatives as anti-inflammatory and analgesic agents.
A series of novel Schiff' base-containing a 7-amino-4-methylcoumarin moiety have been synthesized III a-l, characterized by spectroscopic data and studied for their anti-inflammatory and analgesic activity. The results of the anti-inflammatory and analgesic activity evaluation of 7-(substituted benzylideneamino)-4-methyl-2H-chromen-2-one derivatives III a-l proved to be comparable or more potent with respect to the reference drugs. In particular, compounds 7-(4-chlorobenzylideneamino)-4-methyl-2H-chromen-2-one III f, 7-(2,4-dichlorobenzylideneamino)-4-methyl-2H-chromen-2-one III g and 7-(4-bromobenzylideneamino)-4-methyl-2H-chromen-2-one III h exhibited potent anti-inflammatory and analgesic activity.
Ronad
Pradeepkumar
P
Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Nanthoor, Mangalore, Karnataka, India. ronad_p@rediffmail.com
Dharbamalla
Satyanarayana
S
Hunshal
Rajesh
R
Maddi
Veeresh
V
D000700:Analgesics / Q000138:chemical synthesis* / Q000633:toxicity; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000633:toxicity; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D003374:Coumarins / Q000737:chemistry; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000188:drug therapy / Q000517:prevention & control; D051379:Mice; D051381:Rats; D012545:Schiff Bases; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D001578:Benzopyrans; D003374:Coumarins; D012545:Schiff Bases