Regulating the conversion between rounded and elongated modes of cancer cell movement.
Switching between elongated and rounded modes of movement allows invasive tumor cells to adapt to varying microenvironments. In a recent issue of Cell, Sanz-Moreno et al. identify DOCK3, NEDD9, WAVE2, and ARHGAP22 as key molecules regulating Rac and Rho signaling that determine the mode of movement driving melanoma cell metastasis.
Croft
Daniel R
DR
The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, UK.
Olson
Michael F
MF
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D002465:Cell Movement / Q000502:physiology*; D020690:GTPase-Activating Proteins / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D020662:Guanine Nucleotide Exchange Factors / Q000378:metabolism; D006801:Humans; D008545:Melanoma / Q000378:metabolism / Q000473:pathology* / Q000556:secondary; D009419:Nerve Tissue Proteins / Q000378:metabolism; D010750:Phosphoproteins / Q000378:metabolism; D015398:Signal Transduction; D051300:Wiskott-Aldrich Syndrome Protein Family / Q000378:metabolism; D020744:rac GTP-Binding Proteins / Q000378:metabolism; D020741:rho GTP-Binding Proteins / Q000378:metabolism
C459590:ARHGAP21 protein, human; C578338:ARHGAP22 protein, human; D048868:Adaptor Proteins, Signal Transducing; C485840:DOCK3 protein, human; D020690:GTPase-Activating Proteins; D020662:Guanine Nucleotide Exchange Factors; C099942:NEDD9 protein, human; D009419:Nerve Tissue Proteins; D010750:Phosphoproteins; C120152:WASF2 protein, human; D051300:Wiskott-Aldrich Syndrome Protein Family; D020744:rac GTP-Binding Proteins; D020741:rho GTP-Binding Proteins