title: Prostatic Zn determination for prostate cancer diagnosis.
abstract: We present our studies of prostatic Zn concentration measurements, carried out in the light of a novel prostate cancer (CAP) diagnosis method proposed by us. The method is based on in vivo prostatic Zn mapping by XRF trans-rectal probe. We report on the extensive clinical studies, intended to assess the validity of the novel proposed diagnostic method. Zn content was measured in vitro in needle-biopsy samples from several hundreds of patients, and was correlated with histological findings and other patient parameters. For this purpose, a technique of absolute Zn content determination in approximately 1mm(3) fresh tissue samples by XRF was developed. The experimental details and the main clinical-evaluation results are presented. We further outline the suggested design of the XRF trans-rectal probe for an efficient in vivo detection and mapping of the Zn fluorescence radiation from the prostate through the rectal wall. Laboratory phantom studies, a preliminary design concept and its expected performance are also reported.
authors.affiliation: Department of Particle Physics, Weizmann Institute of Science, POB 26, Rehovot 76100, Israel.
authors.forename: S Sh
authors.initials: SSh
authors.lastname: Shilstein
authors.forename: M
authors.initials: M
authors.lastname: Cortesi
authors.forename: A
authors.initials: A
authors.lastname: Breskin
authors.forename: R
authors.initials: R
authors.lastname: Chechik
authors.forename: D
authors.initials: D
authors.lastname: Vartsky
authors.forename: G
authors.initials: G
authors.lastname: Raviv
authors.forename: N
authors.initials: N
authors.lastname: Kleinman
authors.forename: J
authors.initials: J
authors.lastname: Ramon
authors.forename: G
authors.initials: G
authors.lastname: Kogan
authors.forename: V
authors.initials: V
authors.lastname: Gladysh
authors.forename: E
authors.initials: E
authors.lastname: Moriel
authors.forename: M
authors.initials: M
authors.lastname: Huszar
authors.forename: A
authors.initials: A
authors.lastname: Volkov
authors.forename: E
authors.initials: E
authors.lastname: Fridman