Acid-base equilibria and assay of benzodiazepines in acetonitrile medium.
The acid-base equilibria of a series of benzodiazepines in acetonitrile have been studied, and pK(HB+) values determined. The theory of such titrations is discussed and simple potentiometric and visual methods in acetonitrile media are proposed for the assay of benzodiazepines in pharmaceutical formulations.
Barbosa
J
J
Department de Química Analítica, Universitat de Barcelona, Barcelona, Spain.
Sanz-Nebot
V
V