[Changes of phospho-JNK expression during the skin burned wound healing].
OBJECTIVE
To observe the changes of expression of phosphorylation c-Jun NH2-terminal kinase (p-JNK) during the skin burned wound healing in patients and discuss the molecular mechanism of burned wound healing.


METHODS
The staining intensity and distribution of p-JNK were detected by immunohistochemistry and routine histology in burned skin samples of 12 patients and normal skin samples of 12 control subjects.


RESULTS
In normal skin, the positive signals of p-JNK were mostly localized in basal layer cells of the epidermis, with a positive rate of (8.8+/-1.3)%. In the burned group, the positive signals of p-JNK were mainly localized in the epidermal cells and some inflammatory cells, with a significantly higher positive rate of (31.2+/-3.3)% than the normal group(P<0.01).


CONCLUSIONS
The changes of p-JNK expression after skin burned might correlate with wound healing.
Xiong
Chang-Yan
CY
School of Forensic Medicine, China Medical University, Shenyang 110001, China.
Guan
Da-Wei
DW
Liu
Zhi-Hui
ZH
Zhen
Bo
B
Zhao
Rui
R
Zhu
Bao-Li
BL
D000328:Adult; D002056:Burns / Q000201:enzymology*; D005260:Female; D005554:Forensic Medicine; D006801:Humans; D048031:JNK Mitogen-Activated Protein Kinases / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010766:Phosphorylation; D011897:Random Allocation; D012867:Skin / Q000201:enzymology / Q000293:injuries*; D014945:Wound Healing
D048031:JNK Mitogen-Activated Protein Kinases