Synthesis and antitumor activity of 3-arylisoquinoline derivatives.
In order to study the structure-activity relationship of 7,8-dimethoxy-2-methyl-3-(4,5-methylen-edioxy-2-vinylphenyl)isoquinoline-1 (2H)-one (2), which has exhibited significant antitumor activity, chemical modifications of2 were performed to yield the corresponding products (3-7). Further systematic uses of an efficient procedure for the synthesis of 3-arylisoquinoline derivatives produced the substituted compounds (9a-9g), which were tested forin vitro antitumor activity against five different human cancer cell lines.
Cho
W J
WJ
College of Pharmacy, Chonnam National University, Yongbong-dong 300 Buk-gu, 500-757, Kwangju, Korea.
Yoo
S J
SJ
Park
M J
MJ
Chung
B H
BH
Lee
C O
CO