Microalbuminuria in nondiabetic and nonhypertensive systolic heart failure patients.
The American Diabetes Association and the National Kidney Foundation define microalbuminuria as an albumin (microg)/creatinine (mg) ratio (ACR) between 30 and 300 microg/mg regardless of sex. Microalbuminuria is associated with increased cardiovascular risk. The authors evaluated the prevalence of microalbuminuria in nondiabetic and nonhypertensive systolic heart failure (SHF) patients. Twenty-seven SHF patients, 18 years and older, with New York Heart Association functional classes II through IV and left ventricular ejection fraction < or =40%, who were nondiabetic and nonhypertensive and not receiving angiotensin-converting enzyme inhibitors, were selected. Twenty-seven healthy individuals, paired according to sex, ethnicity, and age, were used as controls. Early-morning midstream urine was used. Data are expressed as medians. Excretion of albumin in SHF patients (39 microg/mL urine) was significantly higher than in controls (26 microg/mL urine). Creatinine excretion was not significantly different between patients and controls. ACR was significantly higher in patients (54 microg/mg) than in controls (24 microg/mg). The results indicate that microalbuminuria was significantly present in nondiabetic and nonhypertensive SHF patients.
Figueiredo
Estêvão L
EL
Programa de Pós-graduação em Clínica Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil. estevao@cardiol.br
Leão
Fabiana V G
FV
Oliveira
Lílian V
LV
Moreira
Maria C V
MC
Figueiredo
Amintas F S
AF
D000328:Adult; D000368:Aged; D000418:Albumins; D000419:Albuminuria / Q000453:epidemiology / Q000503:physiopathology*; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D003404:Creatinine / Q000652:urine; D005260:Female; D006305:Health Status Indicators; D054143:Heart Failure, Systolic / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D013318:Stroke Volume; D016277:Ventricular Function, Left
D000418:Albumins; D003404:Creatinine