[Molecular genetics of cognitive deficit in schizophrenia].
Cognitive deficit is a key feature of schizophrenia. Genetic factors are thought to contribute to cognitive disturbances in schizophrenia patients. However the role of specific-genes in the development of cognitive deficit remains unclear. The article aims at reviewing the current studies devoted to association between gene polymorphisms and cognitive dysfunctions in schizophrenic patients. Main attention is drawn to the association between the Val158Met polymorphism of the COMT gene and cognitive traits that has been consistently replicated and has a biological and neuropsychological support. The association studies on the genes for dopamine and serotonin receptors, brain-derived neurotrophic factor, dysbindin, DISC1, D-amino acid oxidase and D-amino acid oxidase activator are reviewed as well.
Golimbet
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D002394:Catechol O-Methyltransferase / Q000235:genetics / Q000378:metabolism; D003072:Cognition Disorders / Q000235:genetics* / Q000503:physiopathology; D005819:Genetic Markers; D006801:Humans; D009414:Nerve Growth Factors / Q000235:genetics / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D009473:Neuronal Plasticity / Q000235:genetics; D011110:Polymorphism, Genetic; D011954:Receptors, Dopamine / Q000235:genetics / Q000378:metabolism; D011985:Receptors, Serotonin / Q000235:genetics / Q000378:metabolism; D012559:Schizophrenia / Q000235:genetics* / Q000503:physiopathology; D012565:Schizophrenic Psychology
C412476:DISC1 protein, human; D005819:Genetic Markers; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D002394:Catechol O-Methyltransferase