title: The effects of etodolac, nimesulid and naproxen sodium on the frequency of sister chromatid exchange after enclused third molars surgery.
abstract: OBJECTIVE
  Non-steroidal anti-inflammatory drugs (NSAID) are frequently used in oral surgical procedures in dentistry. The evaluation of the frequency of sister chromatid exchange (SCE) is accepted as a reliable cytogenetic method to assess the genotoxic effects of environmental factors.
  
  
  METHODS
  In this study, the genotoxic effects of various NSAIDs were assessed in 30 patients to who they were administered following encluosed third molar surgery using SCE analysis before and after the operation. The frequency of SCE was evaluated before the operation and after 3 days of etodolac, nimesulid and naproxen use.
  
  
  RESULTS
  There was no statistically significant difference in the frequency of SCE between the preoperative and postoperative states in patients given etodolac, nimesulid or naproxen sodium.
  
  
  CONCLUSIONS
  Short term use of selective and non-selective NSAIDs was not associated with a significant genotoxic effect that could be detected using the SCE method in peripheric lymphocytes.
authors.affiliation: Department of Oral Surgery, Istanbul University, Faculty of Dentistry, Istanbul, Turkey. banugr@gmail.com
authors.forename: Banu Gurkan
authors.initials: BG
authors.lastname: Koseoglu
authors.forename: Sukru
authors.initials: S
authors.lastname: Ozturk
authors.forename: Hulya
authors.initials: H
authors.lastname: Kocak
authors.forename: Sukru
authors.initials: S
authors.lastname: Palanduz
authors.forename: Kivanc
authors.initials: K
authors.lastname: Cefle
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D017308:Etodolac / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008964:Molar, Third / Q000601:surgery*; D009152:Mutagenicity Tests; D009288:Naproxen / Q000009:adverse effects; D011446:Prospective Studies; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D013449:Sulfonamides / Q000009:adverse effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013449:Sulfonamides; D017308:Etodolac; D009288:Naproxen; C012655:nimesulide