title: Synthesis and antitumor activity of 3-arylisoquinoline derivatives.
abstract: In order to study the structure-activity relationship of 7,8-dimethoxy-2-methyl-3-(4,5-methylen-edioxy-2-vinylphenyl)isoquinoline-1 (2H)-one (2), which has exhibited significant antitumor activity, chemical modifications of2 were performed to yield the corresponding products (3-7). Further systematic uses of an efficient procedure for the synthesis of 3-arylisoquinoline derivatives produced the substituted compounds (9a-9g), which were tested forin vitro antitumor activity against five different human cancer cell lines.
authors.affiliation: College of Pharmacy, Chonnam National University, Yongbong-dong 300 Buk-gu, 500-757, Kwangju, Korea.
authors.forename: W J
authors.initials: WJ
authors.lastname: Cho
authors.forename: S J
authors.initials: SJ
authors.lastname: Yoo
authors.forename: M J
authors.initials: MJ
authors.lastname: Park
authors.forename: B H
authors.initials: BH
authors.lastname: Chung
authors.forename: C O
authors.initials: CO
authors.lastname: Lee