title: Direct optical detection in fragment-based screening.
abstract: Label-free biosensors based on direct optical detection principles are widely used in many different fields of research. Currently the higher level of automation and the increasing throughput of this technology are stimulating the interest of pharmaceutical companies. The information gained with label-free biosensors can be extremely valuable during the drug design process, particularly in combination with complementary techniques, including NMR, mass spectrometry and X-ray crystallography. In this article we focus on the advantages of direct optical biosensors especially in the field of fragment-based drug design, which is a widely used and extremely promising concept. Furthermore, we present optical biosensors as versatile tools for fragment-based screening and the future drug design process.
authors.affiliation: Institute of Physical and Theoretical Chemistry, Eberhard Karls University of Tübingen, Auf der Morgenstelle 8, 72076, Tübingen, Germany. florian.proell@ipc.uni-tuebingen.de
authors.forename: Florian
authors.initials: F
authors.lastname: Pröll
authors.forename: Peter
authors.initials: P
authors.lastname: Fechner
authors.forename: Günther
authors.initials: G
authors.lastname: Proll
mesh_terms: D015374:Biosensing Techniques; D018360:Crystallography, X-Ray; D015195:Drug Design; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry