title: Plastified poly(ethylene terephthalate) (PET)-toner microfluidic chip by direct-printing integrated with electrochemical detection for pharmaceutical analysis.
abstract: Rapid separation and determination of acetaminophen and its hydrolysate with end-channel electrochemical (EC) detection integrated on a plastified poly(ethylene terephthalate) (PET)-toner microchip capillary electrophoresis (CE) system was investigated. In this separation and detection system, a Pt ultramicroelectrode integrated on a three-dimensional adjustor was used as working electrode. Factors influencing the separation and detection were investigated and optimized. Results show that acetaminophen and p-aminophenol can be well separated within 84s with R.S.D.<1% for migration time and R.S.D.<3.6% for detection current for both analytes. Detection limits for both analytes are determined to be 5.0muM (S/N=3). This method has been successfully applied to the detection of trace p-aminophenol in paracetamol tablets. The results demonstrate that the PET-toner microchips can obtain better performance than PDMS microfluidic devices but at much lower cost.
authors.affiliation: Key Laboratory of Analytical Chemistry for Life Science, Department of Chemistry, Nanjing University, Nanjing 210093, China.
authors.forename: Ai-Lin
authors.initials: AL
authors.lastname: Liu
authors.forename: Feng-Yun
authors.initials: FY
authors.lastname: He
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Hu
authors.forename: Xing-Hua
authors.initials: XH
authors.lastname: Xia