Applications of enzyme-catalysed reactions in trace analysis-VII Determination of lead and indium by their inhibition of isocitrate dehydrogenase.
The inhibition of isocitrate dehydrogenase by lead, indium and calcium has been studied. Methods for the determination of 0.024-1 mug of lead and indium, based on this inhibition, are outlined. Lead may be separeted from some interfering ions by extraction with tributyl phosphate in isobutyl methyl ketone, before application of the enzymic reaction.
Sheikh
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Chemistry Department, The University. P.O. Box 363, Birmingham 15, England.
Townshend
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