Studies on chemically crosslinkable carboxy terminated-poly(propylene fumarate-co-ethylene glycol)-acrylamide hydrogel as an injectable biomaterial.
Carboxy terminated-poly(propylene fumarate)-co-ethylene glycol) (CT-PPF-co-PEG) was prepared and set into crosslinked hydrogel material with acrylamide. The setting studies reveal that this copolymer system can be used as an injectable material. The hydrogel material exhibits a higher degree of swelling, good mechanical strength and flexibility. The hydrogel favours adhesion of L929 fibroblast cells without proliferation on the surface. However, cardiac fibroblast cells (isolated from new born rat (Wistar) hearts) adhere and proliferate on the hydrogel due to the formation of synergistic hydrophilic-hydrophobic surface-by-surface reorganization.
Kallukalam
B C
BC
Polymer Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram 695 012, India.
Jayabalan
M
M
Sankar
V
V
D000818:Animals; D000831:Animals, Newborn; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000737:chemistry*; D002448:Cell Adhesion / Q000502:physiology; D002460:Cell Line; D003432:Cross-Linking Reagents; D005347:Fibroblasts / Q000502:physiology*; D020100:Hydrogels / Q000737:chemistry*; D007267:Injections; D008422:Materials Testing; D051379:Mice; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000737:chemistry*; D011126:Polypropylenes / Q000008:administration & dosage / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D020100:Hydrogels; D011126:Polypropylenes; C115157:poly(propylene fumarate-co-ethylene glycol); D011092:Polyethylene Glycols