title: Large-scale assignment of orthology: back to phylogenetics?
abstract: Reliable orthology prediction is central to comparative genomics. Although orthology is defined by phylogenetic criteria, most automated prediction methods are based on pairwise sequence comparisons. Recently, automated phylogeny-based orthology prediction has emerged as a feasible alternative for genome-wide studies.
authors.affiliation: Bioinformatics and Genomics Program, Center for Genomic Regulation, Doctor Aiguader 88, Barcelona, Spain. tgabaldon@crg.es
authors.forename: Toni
authors.initials: T
authors.lastname: Gabaldón
mesh_terms: D030541:Databases, Genetic; D016678:Genome; D023281:Genomics / Q000379:methods*; D008957:Models, Genetic; D010802:Phylogeny; D016415:Sequence Alignment / Q000379:methods