Synthesis and activity of a potent alpha-glucosidase inhibitor, (1R, 6R, 8S)-cis-1,6-dihydroxypyrrolizidine, and its isomer.
The synthesis ofcis- and trans-1,6-dihydroxypyrrolizidine starting fromtrans-4-hydroxyl-L-proline and their evaluation as glycosidase inhibitors are reported. Thecis-isomer was found to be a potent inhibitor against alpha-glucosidase and showed weak inhibitory effect against other glycosidases. Thetrans-isomer exhibited weak inhibitions of b-glucosidase and amyloglucosidase and poor inhibition of other glycosidases.
Jung
K E
KE
Korea Institute of Science and Technology, 39-1 Hawalgog-Dong, Sungbuk-Gu, 136-791, Seoul, Korea.
Kang
Y K
YK
Kim
D J
DJ
Park
S W
SW