title: Phosphate diester and DNA hydrolysis by a multivalent, nanoparticle-based catalyst.
abstract: 2-nm gold nanoclusters coated with Zn(II) complexes bearing auxiliary hydrogen bond donors act as multivalent catalysts capable of promoting the hydrolysis of model phosphate diesters with exceptional activity and inducing DNA double strand cleavage.
authors.affiliation: Dipartimento di Scienze Chimiche and CNR-ITM, Universita di Padova, Padova, Italy.
authors.forename: Renato
authors.initials: R
authors.lastname: Bonomi
authors.forename: Francesco
authors.initials: F
authors.lastname: Selvestrel
authors.forename: Valentina
authors.initials: V
authors.lastname: Lombardo
authors.forename: Claudia
authors.initials: C
authors.lastname: Sissi
authors.forename: Stefano
authors.initials: S
authors.lastname: Polizzi
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Mancin
authors.forename: Umberto
authors.initials: U
authors.lastname: Tonellato
authors.forename: Paolo
authors.initials: P
authors.lastname: Scrimin
mesh_terms: D002384:Catalysis; D004247:DNA / Q000737:chemistry*; D004952:Esters / Q000737:chemistry*; D006868:Hydrolysis; D008024:Ligands; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D010710:Phosphates / Q000737:chemistry*; D010957:Plasmids / Q000737:chemistry
chemical_list: D004952:Esters; D008024:Ligands; D010710:Phosphates; D004247:DNA