Synthesis of novel heterocycles through reaction of indolin-2-one derivatives with active methylene and amino reagents.
Several new spiro compounds were synthesized via one-pot ternary condensation of isatin, malononitrile and each of thiobarbituric acid, barbituric acid, 3-methyl-pyrazolin-5-one, 1-phenyl-3-methyl-pyrazolin-5-one, acetylacetone, benzoylacetone, ethyl acetoacetate, phenacyl cyanide or ethyl-cyanoacetate dimer. Structures and reaction mechanism were reported and supported via a second synthetic route.
Abdel-Latif
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Chemstry Department, Faculty of Science, El-Minia University, El-Minia, Egypt.
Ahmed
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EK
Mekheimer
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Mashaly
M M
MM