[Not Available].
Weak bases can be titrated potentiometrically or conductimetrically in phenol-water mixture (90/10 w/w). A spectrophotometric study in presence of 2,4-dinitrophenol is used to establish a classification of organic bases that is superposable on that found for other solvents; measurement of the dielectric constant confirms that the solvent is a hemihydrate. The methods of titration and range of application to many organic bases of pharmaceutical interest are described.
Pellerin
F
F
Laboratoire de Chimie Analytique, Centre d'Etudes Pharmaceutiques, Rue J. B. Clément, 92290 Chatenay-Malabry, France.
Baylocq-Quinault
D
D