title: [Hemorrhagic pericardial effusion and multiple pulmonary nodules in a 37 year old male who has "never smoked"].
abstract: Even people which have never smoked can develop lung cancer. In this population a mutation in the exons 19-21 of the Epidermal Growth Factor Receptor (EGFR) can be detected. For this patient group targeted therapies with EGFR tyrosinkinase inhibitors are available. In this case report we describe a 37 year old non-smoker who developed a non-small cell lung cancer. Following therapy with Erlotinib a partial response could be achieved.
authors.affiliation: III. Medizinische Klinik und Poliklinik, Johannes Gutenberg-Universität, Langenbeckstrasse 1, 55101 Mainz. m.sebastian@3-med.klinik.uni-mainz.de
authors.forename: M
authors.initials: M
authors.lastname: Sebastian
authors.forename: A
authors.initials: A
authors.lastname: Schad
authors.forename: S
authors.initials: S
authors.lastname: Schadmand-Fischer
authors.forename: F
authors.initials: F
authors.lastname: Post
authors.forename: S
authors.initials: S
authors.lastname: Meier
authors.forename: E
authors.initials: E
authors.lastname: Springer
authors.forename: J
authors.initials: J
authors.lastname: Makowski
authors.forename: C
authors.initials: C
authors.lastname: Taube
authors.forename: R
authors.initials: R
authors.lastname: Wiewrodt
authors.forename: B
authors.initials: B
authors.lastname: Fischer
authors.forename: R
authors.initials: R
authors.lastname: Buhl
mesh_terms: D000328:Adult; D000069347:Erlotinib Hydrochloride; D006470:Hemorrhage / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D055613:Multiple Pulmonary Nodules / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D010490:Pericardial Effusion / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control*; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D011799:Quinazolines / Q000627:therapeutic use*; D012907:Smoking; D016896:Treatment Outcome
chemical_list: D047428:Protein Kinase Inhibitors; D011799:Quinazolines; D000069347:Erlotinib Hydrochloride