title: Nutritional recovery in HIV-infected and HIV-uninfected children with severe acute malnutrition.
abstract: OBJECTIVE
  Few studies have reported on nutritional recovery, survival and growth among severely malnourished children with HIV. This study explores nutritional recovery in HIV-infected and HIV-uninfected children during inpatient nutrition rehabilitation and 4 months of follow-up.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  Lilongwe district, Malawi.
  
  
  METHODS
  Weight gain, anthropometrics.
  
  
  RESULTS
  In our sample of 454 children with severe acute malnutrition (SAM), 17.4% (n = 79) of children were HIV infected. None of the children were on antiretroviral therapy upon admission. Among the HIV-infected children, 35.4% (28/79) died, compared with 10.4% (39/375) in HIV-uninfected children (p<0.001). All children who survived achieved nutritional recovery (>85% weight for height and no oedema), regardless of HIV status. HIV-infected children had similar weight gain to HIV-uninfected children (8.9 vs 8.0 g/kg/d, not significant (NS)). Mean increases in z-scores for both subscapular (2.72 vs 2.69, NS) and triceps (1.26 vs 1.48, NS) skinfolds were similar between HIV-infected and HIV-uninfected children, respectively, during nutrition rehabilitation. 362 children were followed for 4 months, at which time mean weight for height z-score was similar in HIV-infected and HIV-uninfected children (-0.85 vs -0.64, NS).
  
  
  CONCLUSIONS
  HIV-infected children with SAM have higher mortality rates than HIV-uninfected children. Among those who survive, however, nutritional recovery is similar in HIV-infected and HIV-uninfected children.
authors.affiliation: Liverpool School of Tropical Medicine, Disease Control Group, Pembroke Place, Liverpool L3 5QA, UK. pamela.fergusson@gmail.com
authors.forename: P
authors.initials: P
authors.lastname: Fergusson
authors.forename: J
authors.initials: J
authors.lastname: Chinkhumba
authors.forename: C
authors.initials: C
authors.lastname: Grijalva-Eternod
authors.forename: T
authors.initials: T
authors.lastname: Banda
authors.forename: C
authors.initials: C
authors.lastname: Mkangama
authors.forename: A
authors.initials: A
authors.lastname: Tomkins
mesh_terms: D000886:Anthropometry; D015362:Child Nutrition Disorders / Q000401:mortality / Q000534:rehabilitation; D002675:Child, Preschool; D015658:HIV Infections / Q000401:mortality*; D015497:HIV-1; D006801:Humans; D007223:Infant; D007228:Infant Nutrition Disorders / Q000401:mortality / Q000534:rehabilitation; D008295:Malawi / Q000453:epidemiology; D044342:Malnutrition / Q000401:mortality* / Q000534:rehabilitation*; D009752:Nutritional Status; D011446:Prospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D015430:Weight Gain