[Poxviral immunomodulatory proteins as new therapeutics for immunocorrection].
There are numerous viral proteins known to date to modulate protective responses of their hosts. Representatives of the Poxviridae family have the greatest number of genes coding for proteins, inhibiting inflammatory responses, activities of interferons, regulating immune reactions and other protective mechanisms of macroorganisms, among viruses. This review regards poxviral immunomodulatory proteins--namely, complement-binding proteins, inhibitors of serine proteases, chemokine- and TNF-binding proteins --that were shown to be efficient therapeutics in various animal models of inflammatory and autoimmune diseases. The prospects of their usage in clinical practice for treating human inflammatory and autoimmune disorders are discussed.
Nepomniashchikh
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Shchelkunov
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D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy*; D018925:Chemokines / Q000276:immunology; D003165:Complement System Proteins / Q000276:immunology; D006801:Humans; D007155:Immunologic Factors / Q000276:immunology / Q000627:therapeutic use*; D007167:Immunotherapy; D007249:Inflammation / Q000276:immunology / Q000628:therapy*; D007372:Interferons / Q000037:antagonists & inhibitors / Q000276:immunology; D011212:Poxviridae / Q000378:metabolism*; D015843:Serpins / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology; D014764:Viral Proteins / Q000276:immunology / Q000627:therapeutic use*
D018925:Chemokines; D007155:Immunologic Factors; D015843:Serpins; D014409:Tumor Necrosis Factor-alpha; D014764:Viral Proteins; D003165:Complement System Proteins; D007372:Interferons