[Recent advances in the detection of recombinant human erythropoiesis and its analogs in doping control].
Recombinant human erythropoietin (rhEPO) is one of hormone dopings. In the recent years, it has been always misused in endurance competition sports. It is extremely difficult to discriminate between the natural endogenous erythropoietin (EPO) and recombinant exogenous hormone because they have identical amino acid sequences, and EPO has a relatively short half-life and very low concentration in blood or urine. In this paper, the research progress on the analysis and detection of rhEPO and its analogs by direct and indirect methods are reviewed. Future direction and prospects of the detection of rhEPO in doping control are discussed based on the research of our group.
Yang
Xia
X
Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China. xyang@pku.edu.cn
Pang
Nannan
N
Liao
Yiping
Y
Liu
Huwei
H
D004300:Doping in Sports / Q000379:methods*; D004920:Erythropoiesis; D004921:Erythropoietin / Q000031:analogs & derivatives* / Q000032:analysis* / Q000235:genetics; D006728:Hormones / Q000032:analysis / Q000737:chemistry / Q000235:genetics; D006801:Humans; D011994:Recombinant Proteins / Q000032:analysis* / Q000737:chemistry / Q000235:genetics; D015813:Substance Abuse Detection / Q000379:methods*
D006728:Hormones; D011994:Recombinant Proteins; D004921:Erythropoietin