Phosphate diester and DNA hydrolysis by a multivalent, nanoparticle-based catalyst.
2-nm gold nanoclusters coated with Zn(II) complexes bearing auxiliary hydrogen bond donors act as multivalent catalysts capable of promoting the hydrolysis of model phosphate diesters with exceptional activity and inducing DNA double strand cleavage.
Bonomi
Renato
R
Dipartimento di Scienze Chimiche and CNR-ITM, Universita di Padova, Padova, Italy.
Selvestrel
Francesco
F
Lombardo
Valentina
V
Sissi
Claudia
C
Polizzi
Stefano
S
Mancin
Fabrizio
F
Tonellato
Umberto
U
Scrimin
Paolo
P
D002384:Catalysis; D004247:DNA / Q000737:chemistry*; D004952:Esters / Q000737:chemistry*; D006868:Hydrolysis; D008024:Ligands; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D010710:Phosphates / Q000737:chemistry*; D010957:Plasmids / Q000737:chemistry
D004952:Esters; D008024:Ligands; D010710:Phosphates; D004247:DNA