Ste20-related proline/alanine-rich kinase: a novel regulator of intestinal inflammation.
Recently, inflammatory bowel disease (IBD) has been the subject of considerable research, with increasing attention being paid to the loss of intestinal epithelial cell barrier function as a mechanism of pathogenesis. Ste20-related proline/alanine-rich kinase (SPAK) is involved in regulating barrier function. SPAK is known to interact with inflammation-related kinases (such as p38, JNK, NKCC1, PKCtheta, WNK and MLCK), and with transcription factor AP-1, resulting in diverse biological phenomena, including cell differentiation, cell transformation and proliferation, cytoskeleton rearrangement, and regulation of chloride transport. This review examines the involvement of Ste20-like kinases and downstream mitogen-activated protein kinases (MAPKs) pathways in the pathogenesis and control of intestinal inflammation. The primary focus will be on the molecular features of intestinal inflammation, with an emphasis on the interaction between SPAK and other molecules, and the effect of these interactions on homeostatic maintenance, cell volume regulation and increased cell permeability in intestinal inflammation.
Yan
Yutao
Y
Emory University, Department of Medicine, Division of Digestive Diseases, 615 Michael Street, Atlanta, GA 30322, United States.
Merlin
Didier
D
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D048429:Cell Size; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D006706:Homeostasis; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology; D007413:Intestinal Mucosa / Q000187:drug effects / Q000201:enzymology* / Q000473:pathology; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D010539:Permeability; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D005765:Gastrointestinal Agents; C116037:PAS domain kinases; D017346:Protein Serine-Threonine Kinases; D020928:Mitogen-Activated Protein Kinases