Beyond licensing and disarming: a quantitative view on NK-cell education.
In this article, we will move beyond the current controversy of different models for NK-cell education and instead discuss the properties characterizing MHC class I-guided functional development of NK cells. We will argue that this development, which represents the endpoint of NK-cell education, is a quantitative and dynamic, and perhaps even reversible, process.
Brodin
Petter
P
Department of Microbiology Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Höglund
Petter
P
D000818:Animals; D015395:Histocompatibility Antigens Class I / Q000502:physiology; D006801:Humans; D007108:Immune Tolerance; D007694:Killer Cells, Natural / Q000276:immunology*; D018448:Models, Immunological
D015395:Histocompatibility Antigens Class I