How do halogen substituents contribute to protein-binding interactions? A thermodynamic study of peptide ligands with diverse aryl halides.
Memic
Adnan
A
Department of Chemistry, Wayne State University, Detroit, MI 48202, USA.
Spaller
Mark R
MR
D000076122:Disks Large Homolog 4 Protein; D054879:Halogenation; D006801:Humans; D006846:Hydrocarbons, Halogenated / Q000737:chemistry* / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins / Q000737:chemistry* / Q000378:metabolism; D008024:Ligands; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding; D011487:Protein Conformation; D013816:Thermodynamics
C501444:DLG4 protein, human; D000076122:Disks Large Homolog 4 Protein; D006846:Hydrocarbons, Halogenated; D047908:Intracellular Signaling Peptides and Proteins; D008024:Ligands; D008565:Membrane Proteins; D010455:Peptides