Synthesis and anti-inflammatory and analgesic activities of phenoxyalkanoic acid derivatives.
The synthesis of phenoxyalkanoic acid derivatives and their anti-inflammatory and analgesic activities are described. Analysis of structure-activity relationships shows that in trichlorophenoxy derivatives anti-edematous potency is associated with the presence of 1-thiopropyl moiety and 2 or 4-aminopyridyl moiety at R' position contributes to the analgesic activity.
Shin
K H
KH
Natural Products Research Institute, Seoul National University, 28, Yeonkeun Dong Chongro-Ku, 110-460, Seoul, Korea.
Lee
E B
EB
Park
S W
SW
Shin
K J
KJ
Kim
D C
DC
Kim
D J
DJ