Total synthesis of bulbophylol-B.
The first total synthesis of bulbophylol-B (1) has been achieved with the longest linear sequence of 12 steps and an overall yield of 17.9% via a new and practical approach to construct the dihydrodibenz[b,f]oxepin skeleton employing Wittig, selective reduction, and intramolecular Ullmann reactions as key steps.
Lin
Jinshun
J
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Zhang
Weige
W
Jiang
Nan
N
Niu
Zeyu
Z
Bao
Kai
K
Zhang
Liang
L
Liu
Dailin
D
Pan
Chao
C
Yao
Xinsheng
X
D001584:Benzoxepins / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D015394:Molecular Structure; D013237:Stereoisomerism
D001584:Benzoxepins; C568003:bulbophylol-B