Reactome knowledgebase of human biological pathways and processes.
Reactome (http://www.reactome.org) is an expert-authored, peer-reviewed knowledgebase of human reactions and pathways that functions as a data mining resource and electronic textbook. Its current release includes 2975 human proteins, 2907 reactions and 4455 literature citations. A new entity-level pathway viewer and improved search and data mining tools facilitate searching and visualizing pathway data and the analysis of user-supplied high-throughput data sets. Reactome has increased its utility to the model organism communities with improved orthology prediction methods allowing pathway inference for 22 species and through collaborations to create manually curated Reactome pathway datasets for species including Arabidopsis, Oryza sativa (rice), Drosophila and Gallus gallus (chicken). Reactome's data content and software can all be freely used and redistributed under open source terms.
Matthews
Lisa
L
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Gopinath
Gopal
G
Gillespie
Marc
M
Caudy
Michael
M
Croft
David
D
de Bono
Bernard
B
Garapati
Phani
P
Hemish
Jill
J
Hermjakob
Henning
H
Jassal
Bijay
B
Kanapin
Alex
A
Lewis
Suzanna
S
Mahajan
Shahana
S
May
Bruce
B
Schmidt
Esther
E
Vastrik
Imre
I
Wu
Guanming
G
Birney
Ewan
E
Stein
Lincoln
L
D'Eustachio
Peter
P
D000818:Animals; D030562:Databases, Protein; D006801:Humans; D053858:Metabolic Networks and Pathways; D023421:Models, Animal; D010829:Physiological Phenomena; D011506:Proteins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction; D012984:Software; D018511:Systems Integration
D011506:Proteins