title: Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
abstract: Copper (II) chloride in the absence of any solvent, efficiently catalyses the synthesis of dihydropyrimidinones (80-96% yields) by the Biginelli reaction. Six compounds were selected and examined their antifungal activities against the radial growth of three fungal species viz., Trichoderma hammatum, Trichoderma koningii and Aspergillus niger.
authors.affiliation: Department of Chemistry, Manipur University, Canchipur, Imphal 795003, Manipur, India. ok_mukherjee@yahoo.co.in
authors.forename: Okram Mukherjee
authors.initials: OM
authors.lastname: Singh
authors.forename: Sarangthem Joychandra
authors.initials: SJ
authors.lastname: Singh
authors.forename: Mutum Babita
authors.initials: MB
authors.lastname: Devi
authors.forename: Laitonjam Nalini
authors.initials: LN
authors.lastname: Devi
authors.forename: Nameirakpam Irabanta
authors.initials: NI
authors.lastname: Singh
authors.forename: Sang-Gyeong
authors.initials: SG
authors.lastname: Lee
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001234:Aspergillus niger / Q000378:metabolism; D002384:Catalysis; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003300:Copper / Q000737:chemistry; D015195:Drug Design; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D011744:Pyrimidinones / Q000138:chemical synthesis / Q000494:pharmacology*; D012997:Solvents / Q000737:chemistry; D013997:Time Factors; D014242:Trichoderma / Q000378:metabolism
chemical_list: D000935:Antifungal Agents; D011744:Pyrimidinones; D012997:Solvents; D003300:Copper; C029892:cupric chloride