Electroanalytical study of sulphamerazine at a glassy-carbon electrode and its determination in pharmaceutical preparations by HPLC with amperometric detection.
An electroanalytical study of the oxidation of sulphamerazine at a glassy-carbon electrode has been made by use of different voltammetric techniques. The limiting current is diffusion-controlled, at pH 7.0, for sulphamerazine in the concentration range 2.0 x 10(-5)-1.0 x 10(-4)M. The limits of determination found for differential pulse voltammetry at a stationary electrode and at a rotating electrode were 5.9 x 10(-6) and 3.3 x 10(-6)M respectively. A reversed-phase HPLC method with amperometric detection for the analysis of sulphamerazine, sulphadiazine and phthalylsulphathiazole mixtures has been developed, and applied to a commercial pharmaceutical preparation.
Carrazon
J M
JM
Department of Analytical Chemistry, Faculty of Chemistry, Complutense University of Madrid, 28040-Madrid, Spain.
Recio
A D
AD
Diez
L M
LM