Spectrophotometric determination of amoxycillin and clavulanic acid in pharmaceutical preparation.
A spectrophotometric procedure for the simultaneous determination of amoxycillin and clavulanic acid in some pharmaceutical preparations has been developed. As the absorption bands of amoxycillin (274 and 227 nm) and clavulanic acid (270 nm) overlap, both Vierordt's method and derivative spectrophotometry have been investigated and evaluated. The first-derivative spectrophotometric method was found to be more accurate, direct and reproducible.
Abdel-Moety
E M
EM
Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Abounassif
M A
MA
Mohamed
M E
ME
Khattab
N A
NA