title: Prostatic squamous metaplasia in a cat with interstitial cell neoplasia in a retained testis.
abstract: An 11-year-old cat with a retained testis was presented with a chronic history of dysuria and bladder atony. Medical therapy failed to alleviate the clinical signs. Contrast radiography demonstrated a diffusely narrowed urethra. During a celiotomy and prepubic urethrostomy, a retained testis, stenosed urethra, and irregularly enlarged prostate were observed. Histopathologic diagnosis was retained testis with a well-differentiated interstitial cell tumor, a poorly differentiated interstitial cell tumor, and marked squamous metaplasia of the prostatic epithelium with suppurative prostatitis. Neoplastic interstitial cells were immunoreactive for Melan A, consistent with reports of Melan A expression in steroid hormone-producing tissue. This is the first report of prostatic squamous metaplasia associated with testicular neoplasia in a felid.
authors.affiliation: Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USA.
authors.forename: A R
authors.initials: AR
authors.lastname: Tucker
authors.forename: J R
authors.initials: JR
authors.lastname: Smith
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000473:pathology*; D002415:Cats; D003456:Cryptorchidism / Q000473:pathology / Q000662:veterinary*; D007984:Leydig Cell Tumor / Q000473:pathology / Q000662:veterinary*; D008297:Male; D008679:Metaplasia; D011467:Prostate / Q000473:pathology*