Studies on the synthesis andin vitro anti-tumor activity of dihydroberberine derivatives.
Three types of dihydroberberine derivatives such as spirobenzylisoquinoline, benzindenoazepine and cyclopropanated quinolizine species were synthesized from dihydroberberine for the investigation on their anti-tumor activity. Among them, cyclopropanated quinolizine species were more effective than spirobenzylisoquinoline and benzindenoazepine against P-388 and L-1210 leukemia cell.
Kim
I J
IJ
College of Pharmacy, Kyung Hee University, Hoeki-Dong, Dongdaemoon-Ku, 130-701, Seoul, Korea.
Park
Y J
YJ
Kim
J I
JI
Lee
K T
KT
Kim
S K
SK