title: Neurochemical dementia diagnostics: assays in CSF and blood.
abstract: In this review, current neurochemical dementia diagnostics (NDD) procedures are presented with a focus on biomarkers in the cerebrospinal fluid (CSF) and blood: amyloid beta peptides, tau protein, and its phosphorylated form (pTau). CSF analysis is an increasingly important tool for early and differential diagnosis of dementia syndromes. Although lumbar puncture is a mildly invasive procedure with a low incidence of complications, establishing blood assays capable of reliably measuring NDD biomarkers is an aim of several studies worldwide.
authors.affiliation: Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, Schwabachanlage 6, Erlangen, Germany.
authors.forename: Piotr
authors.initials: P
authors.lastname: Lewczuk
authors.forename: Joachim
authors.initials: J
authors.lastname: Hornegger
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Zimmermann
authors.forename: Markus
authors.initials: M
authors.lastname: Otto
authors.forename: Jens
authors.initials: J
authors.lastname: Wiltfang
authors.forename: Johannes
authors.initials: J
authors.lastname: Kornhuber
mesh_terms: D016229:Amyloid beta-Peptides / Q000097:blood / Q000134:cerebrospinal fluid; D000818:Animals; D003704:Dementia / Q000097:blood / Q000134:cerebrospinal fluid / Q000175:diagnosis; D006801:Humans; D009448:Neurochemistry; D010766:Phosphorylation; D016875:tau Proteins / Q000097:blood / Q000134:cerebrospinal fluid
chemical_list: D016229:Amyloid beta-Peptides; D016875:tau Proteins