title: Multibiosensor based on enzyme inhibition analysis for determination of different toxic substances.
abstract: An original concept of an enzyme multibiosensor for determination of toxic substances based on enzyme inhibition analysis has been proposed and its main performances have been analysed. For the development of this multibiosensor, two types of transducers such as potentiometric pH-sensitive field-effect transistors and conductometric thin-films interdigitated electrodes, and three enzymes, namely urease, acetylcholinesterase and butyrylcholinesterase have been used. The experimental data have been treated by multivariate correspondence analysis. A complete procedure for a simultaneous determination of some heavy metal ions and pesticides has been proposed and its advantages have been discussed.
authors.affiliation: Institute of Molecular Biology & Genetics, National Academy of Sciences of Ukraine, 150 Zabolotnogo Street, Kiev 03143, Ukraine.
authors.forename: V N
authors.initials: VN
authors.lastname: Arkhypova
authors.forename: S V
authors.initials: SV
authors.lastname: Dzyadevych
authors.forename: A P
authors.initials: AP
authors.lastname: Soldatkin
authors.forename: A V
authors.initials: AV
authors.lastname: El'skaya
authors.forename: N
authors.initials: N
authors.lastname: Jaffrezic-Renault
authors.forename: H
authors.initials: H
authors.lastname: Jaffrezic
authors.forename: C
authors.initials: C
authors.lastname: Martelet