title: Elevated RNA polymerase III transcription drives proliferation and oncogenic transformation.
abstract: RNA polymerase (Pol) III is the largest of the RNA polymerases with seventeen subunits. It is responsible for the production of short, untranslated RNAs that play important roles in determining the biosynthetic capacity of the cell. Pol III transcription is generally elevated in transformed cells and tumours; however, it has remained a matter for conjecture as to whether this activation is a cause or consequence of the transformation process.
authors.affiliation: Beatson Institute for Cancer Research, Garscube Estate, Bearsden, Glasgow, United Kingdom. L.Marshall@Beatson.gla.ac.uk
authors.forename: Lynne
authors.initials: L
authors.lastname: Marshall
mesh_terms: D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics / Q000473:pathology / Q000628:therapy; D012320:RNA Polymerase III / Q000235:genetics*; D014158:Transcription, Genetic
chemical_list: D012320:RNA Polymerase III