title: Chemomodulatory action of Foeniculum vulgare (Fennel) on skin and forestomach papillomagenesis, enzymes associated with xenobiotic metabolism and antioxidant status in murine model system.
abstract: The chemopreventive effect of different doses of test diet of Foeniculum vulgare Mill (Fennel) seeds was examined on DMBA-induced skin and B(a)P-induced forestomach papillomagenesis in Swiss albino mice. To the best of our knowledge, this is the first report of Fennel seeds exhibiting a significant reduction in the skin and the forestomach tumor incidence and tumor multiplicity as compared to the control group. Further, biochemical assays showed a significant increase in the content/activities of phase I enzymes especially in the case of 6% test diet. A concomitant increase in the activities of the phase II enzymes were observed with all the doses of test diet under study. A significant enhancement in the activities of antioxidant enzymes were observed especially at 4% and 6% test diets of Fennel. Glyoxalase I activity and the content of reduced glutathione were significantly elevated. Expectedly, the levels of peroxidative damage along with lactate dehydrogenase activity, exhibited a significant reduction at all three doses of test diets. These findings were indicative of chemopreventive potential of Fennel against carcinogenesis.
authors.affiliation: Radiation and Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, Lab No. 215, New Delhi 110067, India. singh.bimala@gmail.com
authors.forename: B
authors.initials: B
authors.lastname: Singh
authors.forename: R K
authors.initials: RK
authors.lastname: Kale
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000037:antagonists & inhibitors / Q000633:toxicity; D000818:Animals; D016588:Anticarcinogenic Agents; D000975:Antioxidants / Q000378:metabolism*; D001835:Body Weight; D002273:Carcinogens / Q000037:antagonists & inhibitors / Q000633:toxicity; D003600:Cytosol / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D030001:Foeniculum / Q000737:chemistry*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D010212:Papilloma / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D010936:Plant Extracts / Q000494:pharmacology; D012878:Skin Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D015262:Xenobiotics / Q000378:metabolism*
chemical_list: D016588:Anticarcinogenic Agents; D000975:Antioxidants; D002273:Carcinogens; D010936:Plant Extracts; D015262:Xenobiotics; D015127:9,10-Dimethyl-1,2-benzanthracene; D007770:L-Lactate Dehydrogenase