title: Interrelationships between B-type natriuretic peptides and vitamin D in patients on maintenance peritoneal dialysis.
abstract: OBJECTIVE
  Experimental evidence suggests that vitamin D deficiency impairs cardiac structure and function. Our objective was to observe relationships between circulating levels of the cardiac natriuretic peptides and vitamin D levels in patients on chronic peritoneal dialysis.
  
  
  METHODS
  Measurements were made of circulating levels of 25-hydroxyvitamin D [25(OH)D] and plasma B-type natriuretic peptide (BNP) levels in patients receiving chronic peritoneal dialysis.
  
  
  RESULTS
  Both BNP and the 1-76 amino-terminal fragment of pro-BNP correlated inversely with 25(OH)D levels (rs = -0.60, p = 0.007, and rs = -0.64, p = 0.003, respectively) in patients on peritoneal dialysis.
  
  
  CONCLUSIONS
  Vitamin D deficiency in chronic renal failure may impair cardiac function, as manifested by elevated levels of B-type cardiac natriuretic peptides.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
authors.forename: Enyioma N
authors.initials: EN
authors.lastname: Obineche
authors.forename: Hussain
authors.initials: H
authors.lastname: Saadi
authors.forename: Sheela
authors.initials: S
authors.lastname: Benedict
authors.forename: Javed Y
authors.initials: JY
authors.lastname: Pathan
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Frampton
authors.forename: M Gary
authors.initials: MG
authors.lastname: Nicholls
mesh_terms: D000328:Adult; D000368:Aged; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010281:Parathyroid Hormone / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D010530:Peritoneal Dialysis; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D010281:Parathyroid Hormone; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D014807:Vitamin D; C104450:25-hydroxyvitamin D; D003404:Creatinine