Meta-analysis of genome-wide linkage scans of attention deficit hyperactivity disorder.
Genetic contribution to the development of attention deficit hyperactivity disorder (ADHD) is well established. Seven independent genome-wide linkage scans have been performed to map loci that increase the risk for ADHD. Although significant linkage signals were identified in some of the studies, there has been limited replications between the various independent datasets. The current study gathered the results from all seven of the ADHD linkage scans and performed a Genome Scan Meta Analysis (GSMA) to identify the genomic region with most consistent linkage evidence across the studies. Genome-wide significant linkage (P(SR) = 0.00034, P(OR) = 0.04) was identified on chromosome 16 between 64 and 83 Mb. In addition there are nine other genomic regions from the GSMA showing nominal or suggestive evidence of linkage. All these linkage results may be informative and focus the search for novel ADHD susceptibility genes.
Zhou
Kaixin
K
Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.
Dempfle
Astrid
A
Arcos-Burgos
Mauricio
M
Bakker
Steven C
SC
Banaschewski
Tobias
T
Biederman
Joseph
J
Buitelaar
Jan
J
Castellanos
F Xavier
FX
Doyle
Alysa
A
Ebstein
Richard P
RP
Ekholm
Jenny
J
Forabosco
Paola
P
Franke
Barbara
B
Freitag
Christine
C
Friedel
Susann
S
Gill
Michael
M
Hebebrand
Johannes
J
Hinney
Anke
A
Jacob
Christian
C
Lesch
Klaus Peter
KP
Loo
Sandra K
SK
Lopera
Francisco
F
McCracken
James T
JT
McGough
James J
JJ
Meyer
Jobst
J
Mick
Eric
E
Miranda
Ana
A
Muenke
Maximilian
M
Mulas
Fernando
F
Nelson
Stanley F
SF
Nguyen
T Trang
TT
Oades
Robert D
RD
Ogdie
Matthew N
MN
Palacio
Juan David
JD
Pineda
David
D
Reif
Andreas
A
Renner
Tobias J
TJ
Roeyers
Herbert
H
Romanos
Marcel
M
Rothenberger
Aribert
A
Schäfer
Helmut
H
Sergeant
Joseph
J
Sinke
Richard J
RJ
Smalley
Susan L
SL
Sonuga-Barke
Edmund
E
Steinhausen
Hans-Christoph
HC
van der Meulen
Emma
E
Walitza
Susanne
S
Warnke
Andreas
A
Lewis
Cathryn M
CM
Faraone
Stephen V
SV
Asherson
Philip
P
D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16; D008040:Genetic Linkage; D015894:Genome, Human; D006801:Humans; D008126:Lod Score; D011336:Probability; D044465:White People