title: On the use of dispersed nanoparticles modified with single layer beta-cyclodextrin as chiral selecor to enhance enantioseparation of clenbuterol with capillary electrophoresis.
abstract: A new strategy for chiral separation by capillary electrophoresis employing modified-nanoparticles as chiral selector is described for clenbuterol analysis. Nanoparticles modified with beta-cyclodextrin (beta-CD) form a large surface area platform to serve as a pseudostationary chiral phase, which can be applied for the enhancement of the enantioseparation. The application of four kinds of nanoparticles was investigated (multi-walled nanotubes (MWNTs), polystyrene (PS), TiO(2) and Al(2)O(3)) modified with single layer beta-CD as chiral selector in the enantioseparation of clenbuterol by capillary electrophoresis (CE). Successful clenbuterol enantioseparation could be achieved with the beta-CD-modified MWNTs as chiral selector. X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) confirmed the beta-CD modification of the nanoparticles. The effects of nanoparticles, surfactant, chiral selector (beta-CD) and run buffer were studied in relation to the enantiomeric separation of clenbuterol. This study opens attractive perspectives for the use of modified nanoparticles for chiral separational purposes in CE.
authors.affiliation: Department of Chemistry, Beijing Normal University, 100875 Beijing, PR China.
authors.forename: Na
authors.initials: N
authors.lastname: Na
authors.forename: Yuping
authors.initials: Y
authors.lastname: Hu
authors.forename: Jin
authors.initials: J
authors.lastname: Ouyang
authors.forename: Willy R G
authors.initials: WR
authors.lastname: Baeyens
authors.forename: Joris R
authors.initials: JR
authors.lastname: Delanghe
authors.forename: Youri E C
authors.initials: YE
authors.lastname: Taes
authors.forename: Mengxia
authors.initials: M
authors.lastname: Xie
authors.forename: Huaying
authors.initials: H
authors.lastname: Chen
authors.forename: Yiping
authors.initials: Y
authors.lastname: Yang