Spectrophotometric determination of ceterizine hydrochloride with Alizarin Red S.
A simple, rapid and sensitive spectrophotometric method has been developed for the assay of ceterizine hydrochloride (CTZH) in bulk drug and its pharmaceutical preparations. This method is based on the ion-pair complex reaction between CTZH and Alizarin Red S in Clarks-Lubs buffer. The chromogen being extractable with chloroform, could be measured quantitatively at 440 nm. All variables were studied to optimise the reaction conditions. Regression analysis of Beer's Law plot showed good correlation in the concentration range 2.5-22 microg ml(-1). The method has a detection limit of 0.1328 microg ml(-1). The proposed method has been successfully applied for the analysis of the bulk drug and its dosage forms such as tablets and syrups. No interference was observed from common pharmaceutical adjuvants.
Basavaiah
K
K
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, India.
SriLatha
Swamy
J M
JM