Antenatal antecedents and the impact of obstetric care in the etiology of cerebral palsy.
Cerebral palsy (CP) affects 2/1000 live-born children. Multiple antenatal factors, including preterm delivery, low birth weight, infection/inflammation, multiple gestation, and other pregnancy complications, are mostly associated with CP in both the preterm and term infant, with birth asphyxia playing a minor role. Owing to the increasing survival of the very preterm and very low birth weight infant secondary to improvements in neonatal and obstetric care, the incidence of CP may be increasing. The focus of this paper is to explore antenatal antecedents as etiologies of CP and the impact of obstetric care on the prevention of CP.
Clark
Shannon M
SM
Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, The University of Texas Medical Branch, Galveston, Texas 77555-0587, USA. shclark@utmb.edu
Ghulmiyyah
Labib M
LM
Hankins
Gary D V
GD
D001238:Asphyxia Neonatorum / Q000150:complications / Q000453:epidemiology*; D001720:Birth Injuries / Q000150:complications / Q000453:epidemiology*; D002547:Cerebral Palsy / Q000453:epidemiology* / Q000209:etiology* / Q000401:mortality; D015897:Comorbidity; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008297:Male; D007744:Obstetric Labor Complications / Q000453:epidemiology*; D009774:Obstetrics / Q000592:standards; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D015995:Prevalence; D012307:Risk Factors; D016019:Survival Analysis