title: Mean q-ball strings obtained by constrained procrustes analysis with point sliding.
abstract: The idea underpinning the work we present herein is to design robust and objective tools for brain white matter (WM) morphometry. We focus on WM tracts, and propose to represent them by their mean lines, to which we associate the attributes derived from high-angular resolution diffusion imaging (HARDI). The definition of the tract mean line derives directly from the geometry of the tract fibres. We determine the fibre point correspondences and impact factors of individual fibres, upon which we estimate average HARDI models along the tract mean lines. This way we obtain a compact tract representation that exploits all the available information, and is at the same time free of the outlier influence and undesired tract edge effects.
authors.affiliation: NeuroSpin, CEA, Gif-sur-Yvette, France 2 IFR49, France.
authors.forename: Irina
authors.initials: I
authors.lastname: Kezele
authors.forename: Cyril
authors.initials: C
authors.lastname: Poupon
authors.forename: Muriel
authors.initials: M
authors.lastname: Perrin
authors.forename: Yann
authors.initials: Y
authors.lastname: Cointepas
authors.forename: Vincent
authors.initials: V
authors.lastname: El Kouby
authors.forename: Fabrice
authors.initials: F
authors.lastname: Poupon
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Mangin
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D001921:Brain / Q000033:anatomy & histology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity