title: Regulation by destruction: design of the sigmaE envelope stress response.
abstract: The signal transduction pathway governing the sigma(E)-dependent cell envelope stress response in Escherichia coli communicates information from the periplasm to sigma(E) in the cytoplasm via a regulated proteolytic cascade that results in the destruction of the membrane-bound antisigma factor, RseA, and the release of sigma(E) to direct transcription. Regulated proteolysis is used for signal transduction in all domains of life, and these pathways bear remarkable similarities in their architecture and the proteases involved. Work with the pathway governing the sigma(E) response has elucidated key design principles that ensure a rapid yet graded response that is buffered from inappropriate activation. Structural and biochemical studies of the proteases that mediate signal transduction reveal the molecular underpinnings enabling this design.
authors.affiliation: Department of Biochemistry and Molecular Biology, 306 S. Frear Laboratory, The Pennsylvania State University, University Park, PA 16802, United States. ades@psu.edu
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Ades
mesh_terms: D004926:Escherichia coli / Q000502:physiology*; D029968:Escherichia coli Proteins / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D008565:Membrane Proteins / Q000378:metabolism; D010447:Peptide Hydrolases / Q000378:metabolism; D012808:Sigma Factor / Q000378:metabolism*; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D029968:Escherichia coli Proteins; D008565:Membrane Proteins; C433802:RseA protein, E coli; D012808:Sigma Factor; D014157:Transcription Factors; C063202:sporulation-specific sigma factors; D010447:Peptide Hydrolases