DNA double-strand break processing: the beginning of the end.
Nucleolytic processing of DNA double-strand breaks (DSBs) generates 3' ssDNA tails that are essential for the assembly of DNA damage checkpoint signaling and DNA repair protein complexes. Genetic studies have provided evidence that multiple nuclease activities are involved in DSB end resection. Three recent studies, including work by Jackson and colleagues (pp. 2767- 2772) in the October 15, 2008, issue of Genes & Development, have begun to shed some light on the intricacy of this process.
Raynard
Steven
S
Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
Niu
Hengyao
H
Sung
Patrick
P
D000818:Animals; D053903:DNA Breaks, Double-Stranded; D004265:DNA Helicases / Q000378:metabolism; D011088:DNA Ligases / Q000378:metabolism; D004260:DNA Repair / Q000502:physiology*; D004261:DNA Replication / Q000502:physiology*; D019143:Evolution, Molecular; D005090:Exodeoxyribonucleases / Q000378:metabolism; D006801:Humans; D045522:Recombinases / Q000378:metabolism; D011995:Recombination, Genetic; D013569:Synapses / Q000502:physiology
D045522:Recombinases; D005090:Exodeoxyribonucleases; D004265:DNA Helicases; D011088:DNA Ligases