title: Effectiveness and safety of loop electrosurgical excision procedure for cervical neoplasia in rural India.
abstract: OBJECTIVE
  To evaluate the effectiveness and safety of loop electrosurgical excision procedure (LEEP) to treat cervical intraepithelial neoplasia (CIN) in rural India.
  
  
  METHODS
  Women with CIN colposcopic features unsuitable for cryotherapy were treated with LEEP using a "see-and-treat" approach. Women with unsatisfactory colposcopy had diagnostic LEEP. Cure was defined as no clinical or histologic evidence of CIN at 1-year follow-up. Factors influencing cure rates were evaluated by chi(2) tests.
  
  
  RESULTS
  Of the 1,141 women who underwent LEEP (569 see-and-treat; 572 unsatisfactory colposcopy), 634 had histologically proven CIN. Of those, 489 reported for follow-up and 459 (93.9%) had no evidence of disease. Cure rates were 98.1% for women with CIN 1, 93.6% for CIN 2, and 85.0% for CIN 3. Patients with CIN 2-3 had significantly lower cure rates.
  
  
  CONCLUSIONS
  Cure rates for LEEP provided by newly trained doctors in rural India were similar to those reported in the gynecological literature.
authors.affiliation: Screening Group, International Agency for Research on Cancer, Lyon, France. sankar@iarc.fr
authors.forename: Rengaswamy
authors.initials: R
authors.lastname: Sankaranarayanan
authors.forename: Vijay
authors.initials: V
authors.lastname: Keshkar
authors.forename: Ashok
authors.initials: A
authors.lastname: Kothari
authors.forename: Shubhada
authors.initials: S
authors.lastname: Kane
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Fayette
authors.forename: Surendra
authors.initials: S
authors.lastname: Shastri
mesh_terms: D000328:Adult; D004598:Electrosurgery / Q000009:adverse effects; D005260:Female; D006801:Humans; D007194:India; D008875:Middle Aged; D012424:Rural Population; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000601:surgery*; D002578:Uterine Cervical Dysplasia / Q000601:surgery*