Highly conducting transmembrane pores formed by aromatic oligoamide macrocycles.
Oligoamide macrocycles 1d and 1e, which carry membrane-compatible side chains and contain a hydrophilic, noncollapsible cavity, were found to mediate high ion flux across a lipid bilayer, as demonstrated by results from (23)Na NMR and planar bilayer conductance measurements. The measured transmembrane single channel currents are very high, rivaling those typically associated with pore-forming protein toxins. The obtained results have demonstrated the promise of developing large, highly conducting channels based on nanopores formed by oligoamide macrocycles.
Helsel
Amber Jade
AJ
Department of Chemistry, Natural Sciences Complex, University at Buffalo, The State University of New York, Buffalo, New York 14260, USA.
Brown
Amy L
AL
Yamato
Kazuhiro
K
Feng
Wen
W
Yuan
Lihua
L
Clements
Aimee J
AJ
Harding
Stephanie V
SV
Szabo
Gabor
G
Shao
Zhifeng
Z
Gong
Bing
B
D000577:Amides / Q000737:chemistry*; D002462:Cell Membrane / Q000737:chemistry*; D047028:Macrocyclic Compounds / Q000737:chemistry*; D015394:Molecular Structure; D016062:Porosity
D000577:Amides; D047028:Macrocyclic Compounds