title: [Using ultrogestan for the treatment of spontaneous abortions and complications of climax in women with epilepsy].
abstract: Epilepsy is a disease, closely connected with sex-hormones and can lead to adverse repercussion on the reproductive health. The ovarial hormones influence excitation of neurocells membranes and have a lot of effects on brain, leading to provoking epileptic activity. The progesteron decrease and the estrogens increase the brain excitation, that's why estrogens (act like a proconvulsant) are proconvulsant and progesteron is anticonvulsant. The aim of this study is to evaluate therapeutic abilities of Utrogestan (micronising progesteron) for treatment of abortions and climacteric amplifications in women with epilepsy. The study is prospectiv and includes 21 women with epilepsy, treated with Utrogestan. The women are divided into two groups: 1-st group --12 pregnant women with symptoms of aborts and 2-nd group--9: 6 with climacteric blooding and 3 with hormone replacement therapy on the occasion of postcastration syndrome. In 13 patients drug is applied through mouth and in 8--through vagina. The vaginal way is used in patients, that accept enzyminductiv antiepilepsy drugs (AED). Utrogestan was applied preventive in 10 pregnant women with symptoms of danger of abortion and in two women with a medicinal aim. In 10 patient pregnancy finished successful with delivery of a healthy child on term, in one--pregnancy is in progress, in one was made interruption. There weren't epilepsy attacks in no one pregnant women, that may be connected with both adequate treatment of epilepsy and with influence of micronising progesteron as anticonvulsant. In the 2-nd group in 4 women with climacteric blooding Utrogestan is applied vaginal from 15-24 day of menstruation to retrieve regularity of cycles. In 3 women with postcastration syndrome Utrogestan is used as a part of hormone substitute treatment (Oestrogel and Utrogestan once a day continuously. The treatment was with very good effect, without changes in the frequency and weight of the epileptic attacks. Results of our study show, that Utrogestan has very good effect in treatment of women with epilepsy. With his natural, herbal origin and micronisation form, as well as possibilities for oral and vaginal application of the same form, Utrogestan tends to take the place of synthetic progesteron analogs, when epilepsy have had a bad influence over reproductive health.
authors.forename: S
authors.initials: S
authors.lastname: Bozhinova
authors.forename: P
authors.initials: P
authors.lastname: Bozhinov
mesh_terms: D000022:Abortion, Spontaneous / Q000378:metabolism / Q000517:prevention & control*; D004334:Drug Administration Schedule; D004827:Epilepsy / Q000150:complications* / Q000378:metabolism; D005260:Female; D020249:Hormone Replacement Therapy / Q000379:methods*; D006801:Humans; D017698:Postmenopause / Q000378:metabolism*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011374:Progesterone / Q000008:administration & dosage / Q000627:therapeutic use*; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D011374:Progesterone