Decomposition mechanism of an artemisinin-type compound via hemin-electrocatalysis.
The interaction between a typical derivative of artemisinin and hemin was investigated by electrochemical and spectroelectrochemical methods. This derivative can be reduced via hemin-catalysis at the glassy carbon electrode, the cathodic overpotential is decreased by ca. 650 mV. A HPLC method for separating the products of the catalytic reaction was established. They were identified either in H(2)O-CH(3)CN solution or in tetrahydrofuran, respectively. The structures of these products show that the hemin-catalyzed decomposition of an artemisinin-type compound on the glassy carbon or reticulated vitreous carbon electrode can be achieved by both electrochemical reduction and rearrangement. The conclusion that the reaction of artemisinin with hemin is a critical step in the antimalarial mechanism of artemisinin can be drawn.
Chen
H Y
HY
Department of Chemistry, The State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, China.
Chen
Y
Y
Zhu
S M
SM
Bian
N S
NS
Shan
F
F
Li
Y
Y