Study of antibacterial activity of ZnZnbisporphyrin complexes and its free components on Staphylococcus aureus by microcalorimetry.
The antibacterial effect of Zn(II), tetraphenyl porphyrin (TPP), propdioxyl bridged tetraphenyl bisporphyrin 1, and its metallobisporphyrin complexes (ZnMnbisporphyrin 2 and ZnZnbisporphyrin 3) towards Staphylococcus aureus growth was investigated by microcalorimetry at 37 degrees C. Differences in their capacities to inhibit the growth metabolism of S. aureus were observed. By analyzing the power-time curves, crucial parameters such as the rate constant of bacterial growth (k), inhibitory ratio (I), and generation time (t (G)) were determined. The growth rate constant (k) of S. aureus (in the log phase) in the presence of the drugs decreased linearly with increasing concentrations of the complexes. The sequence of the antibacterial activities of these compounds tested was 3 > 2 > 1 > Zn(II) > TPP. ZnZnbisporphyrin 3 is proposed to benefit from the synergetic effects of Zn(II) and 1.
Xu
Xiang-Jiao
XJ
State Key Laboratory of Virology, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, China.
Chen
Chun-Qiao
CQ
Wang
Zhuo-Yuan
ZY
Zhang
Yi
Y
Hou
An-Xin
AX
Li
Chao-Hong
CH
Liu
Yi
Y
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D002151:Calorimetry; D008665:Metalloporphyrins / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011166:Porphyrins / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development; D013696:Temperature; D017967:Zinc Compounds / Q000737:chemistry / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D008665:Metalloporphyrins; D011166:Porphyrins; D017967:Zinc Compounds