title: Efficacy of short-term cyclosporine treatment to control psoriasis-related events during efalizumab therapy.
abstract: Efalizumab is a recombinant humanized anti-CD11a monoclonal antibody that blocks the activation, adhesion and trafficking of T cells and has been approved for the treatment of moderate-to-severe plaque psoriasis. To document management of the fluctuations in symptom control that patients with psoriasis sometimes experience during treatment, we performed a retrospective analysis of our experience using cyclosporine as an intercurrent treatment to control psoriasis-related adverse events (AEs) in 10 patients who had received continuous efalizumab therapy for 20-200 weeks prior to recurrence of symptoms. Combination therapy with cyclosporine and efalizumab was generally well tolerated and controlled the relapse effectively. There were no reports of severe AEs during combination treatment, and no clinically significant changes were noted in clinical and laboratory values. Although mild, localized psoriasis recurred in most of these patients after cyclosporine termination, no patient experienced rebound or psoriasis flare and all continued with long-term efalizumab treatment.
authors.affiliation: Department of Dermatology, University of Rome Tor Vergata, Viale Oxford 81, Rome, Italy. antonio.costanzo@uniroma2.it
authors.forename: Antonio
authors.initials: A
authors.lastname: Costanzo
authors.forename: Marina
authors.initials: M
authors.lastname: Talamonti
authors.forename: Giulia
authors.initials: G
authors.lastname: Spallone
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Botti
authors.forename: Maria Sole
authors.initials: MS
authors.lastname: Chimenti
authors.forename: Marina
authors.initials: M
authors.lastname: Papoutsaki
authors.forename: Sergio
authors.initials: S
authors.lastname: Chimenti
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D018845:CD11 Antigens / Q000276:immunology*; D003524:Cyclosporins / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy*; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D018845:CD11 Antigens; D003524:Cyclosporins; D007166:Immunosuppressive Agents; C472181:efalizumab