title: Analysis of anthranilic acid by liquid chromatography.
abstract: Analytical methods for the assay of anthranilic acid and for determination of the impurities methyl anthranilate, anthranoylanthranilic acid and 3- and 4-aminobenzoic acid are described. A Microbondapak C18 column is used for both the assay and the impurity determination. The assay is based on isocratic development with a mobile phase of 35:65 v v methanol/pH-3 phosphate buffer, with benzoic acid as internal standard. The impurities are separated by gradient elution. The standard deviation of the assay method is about 1% and the limit of detection for the impurities is about 0.01%.
authors.affiliation: Central Research and Development, BASF Wyandotte Corporation, Wyandotte, MI 48192, USA.
authors.forename: T M
authors.initials: TM
authors.lastname: Schmitt
authors.forename: R J
authors.initials: RJ
authors.lastname: Ziegler
authors.forename: E S
authors.initials: ES
authors.lastname: Muzher
authors.forename: R J
authors.initials: RJ
authors.lastname: Doyle
authors.forename: J L
authors.initials: JL
authors.lastname: Freers