title: Rapid encephalopathy associated with anti-D immune globulin treatment for idiopathic thrombocytopenic purpura.
abstract: Rho (D) immune globulin intravenous (IV RhIG, WinRho SDF) has been shown to be a safe treatment for idiopathic thrombocytopenic purpura. Common side effects of IV RhIG include mild hemolysis, febrile reaction and headache. Significant hemolysis with renal impairment is infrequently noted. A single case of irreversible encephalopathy following IV RhIG has been reported. We report a second case of encephalopathy following an infusion of IV RhIG for treatment of idiopathic thrombocytopenic purpura.
authors.affiliation: Department of Medicine, MetroWest Medical Center, Framingham, Mass., USA.
authors.forename: Sunitha
authors.initials: S
authors.lastname: Golla
authors.forename: Clare
authors.initials: C
authors.lastname: Horkan
authors.forename: Grigore
authors.initials: G
authors.lastname: Dogaru
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Teske
authors.forename: Kenneth
authors.initials: K
authors.lastname: Christopher
mesh_terms: D000369:Aged, 80 and over; D002543:Cerebral Hemorrhage; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D020258:Neurotoxicity Syndromes / Q000175:diagnosis / Q000209:etiology*; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications / Q000188:drug therapy*; D018029:Rho(D) Immune Globulin / Q000009:adverse effects*
chemical_list: D018029:Rho(D) Immune Globulin