[Study on the effect of phloretin on inhibiting malignant pheotype of BEL-7402 cells].
OBJECTIVE
To investigate the effect of phloretin on inhibiting BEL-7402 cells' growth, invasive, migration and adhesion ability and the rate of colony formation.


METHODS
BEL-7402 cells' growth, invasive, migration and adhesion ability and the rate of colony formation were examined with MIT method and Costar Transwell.


RESULTS
Phloretin inhibited the growth, invasive, migration and adhesion ability of BEL-7402 cells and reduced the rate of colony formation in dose-dependent.


CONCLUSIONS
Phloretin can inhibit BEL-7402 cells' malignant pheotype.
Luo
Hui
H
Department of Chemistry, Guangdong Medical College, Zhanjiang 524023, China. luohui@gdmc.edn.cn
Wang
Ya-Jun
YJ
Chen
Jie
J
Liu
Jiang-Qin
JQ
D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D002448:Cell Adhesion / Q000187:drug effects; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D010641:Phenotype; D010693:Phloretin / Q000008:administration & dosage / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D010693:Phloretin