The distribution of HBV genotypes and clinical significance in familial clustering in an infected population with unfavorable prognosis.
Using a nested-PCR genotyping system, we analyzed the viral genotypes in HBV-infected patients from HBV clustering infection families (CIFs), as compared with HBV infected patients without familial infection history. The patients in the CIF group showed significantly increased prevalence of genotype C infection, while genotype B was absent. Additionally, in the genotype C carriers younger than 50 years old, the prevalence of HCC and LC were significantly increased in CIF compared to the control. We found that HBeAg-positive HBV genotype C carriers are prone to develop end-stage liver diseases earlier than those infected by genotype B.
Liu
Jinfeng
J
Department of Infectious Diseases, The First Affiliated Hospital of Xi'an JiaoTong University School of Medicine, 710061, Xi'an, Shaanxi Province, China. sourmilk2003@163.com
Li
Yongqin
Y
Chen
Tianyan
T
Yang
Yuan
Y
Wang
Ke
K
He
Yingli
Y
Yang
Qian
Q
Ye
Feng
F
Jin
Yan
Y
Qiu
Ting
T
Lin
Shumei
S
Liu
Min
M
Zhao
Yingren
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D002353:Carrier State / Q000821:virology; D002648:Child; D002675:Child, Preschool; D002681:China; D005192:Family Health; D005260:Female; D005838:Genotype; D006513:Hepatitis B e Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000235:genetics* / Q000302:isolation & purification; D019694:Hepatitis B, Chronic / Q000175:diagnosis* / Q000821:virology; D006801:Humans; D008107:Liver Diseases / Q000175:diagnosis / Q000821:virology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D055815:Young Adult
D006513:Hepatitis B e Antigens