title: Surface silver-doping of biocompatible glasses to induce antibacterial properties. Part II: Plasma sprayed glass-coatings.
abstract: A 57% SiO(2), 3% Al(2)O(3), 34% CaO and 6% Na(2)O glass (SCNA) has been produced in form of powders and deposited by plasma spray on titanium alloy and stainless steel substrates. The obtained coatings have been subjected to a patented ion-exchange treatment to introduce silver ions in the surface inducing an antibacterial behavior. Silver surface-enriched samples have been characterized by means of X-ray diffraction, SEM observation, EDS analysis, in vitro bioactivity tests, leaching tests by GFAAS (graphite furnace atomic adsorption spectroscopy) analyses, cells adhesion and proliferation, and antibacterial tests using Staphylococcus Aureus strain. In vitro tests results showed that the modified samples acquired an antimicrobial action against tested bacteria maintaining unaffected the biocompatibility of the glass. Furthermore the ion-exchange treatment can be successfully applied to glass-coated samples without affecting the properties of the coatings; the simplicity and reproducibility of the method make it suitable for glass or glass-ceramic coatings of different composition in order to produce coated devices for bone healing and/or prostheses, able to reduce bacterial colonization and infections risks.
authors.affiliation: Materials Science and Chemical Engineering Department, Polytechnic of Turin, Turin, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Miola
authors.forename: S
authors.initials: S
authors.lastname: Ferraris
authors.forename: S
authors.initials: S
authors.lastname: Di Nunzio
authors.forename: P F
authors.initials: PF
authors.lastname: Robotti
authors.forename: G
authors.initials: G
authors.lastname: Bianchi
authors.forename: G
authors.initials: G
authors.lastname: Fucale
authors.forename: G
authors.initials: G
authors.lastname: Maina
authors.forename: M
authors.initials: M
authors.lastname: Cannas
authors.forename: S
authors.initials: S
authors.lastname: Gatti
authors.forename: A
authors.initials: A
authors.lastname: Massé
authors.forename: C
authors.initials: C
authors.lastname: Vitale Brovarone
authors.forename: E
authors.initials: E
authors.lastname: Verné
mesh_terms: D000497:Alloys; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001696:Biomechanical Phenomena; D001826:Body Fluids; D002460:Cell Line; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000494:pharmacology*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D005898:Glass / Q000737:chemistry; D066298:In Vitro Techniques; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D012834:Silver / Q000494:pharmacology*; D013193:Stainless Steel; D013211:Staphylococcus aureus / Q000187:drug effects; D013499:Surface Properties; D013816:Thermodynamics; D014025:Titanium; D014961:X-Ray Diffraction
chemical_list: D000497:Alloys; D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D013193:Stainless Steel; C031462:titanium alloy (TiAl6V4); D012834:Silver; D014025:Titanium