title: New liquid-membrane electrodes for direct determination of atropine in pharmaceutical preparations.
abstract: Solutions of atropinium 5-nitrobarbiturate in n-octanol and atropinium picrolonate in p-nitrotoluene are used as novel liquid ion-exchangers in electrodes that respond to the atropine cation. The performance characteristics of the two electrodes are almost identical: the response is linear for 10(-5)-10(-2)M atropine with a slope of 56.5 +/- 1 mV/concentration decade. The static response times are 30-90 sec and the potential readings are stable over the pH range 3-8. There is negligible interference from a number of inorganic and organic cations, and some common excipients. In the direct determination of 1-200 mug/ml of atropine, the average recovery with both electrodes is 98% (mean standard deviation 1.7%). Atropine has been determined in some pharmaceutical preparations with an average recovery of 98% (standard deviation 1.9%), the results being in agreement with those obtained by standard methods.
authors.affiliation: Department of Chemistry, Faculty of Science, Ain Shams University, Cairo, Egypt.
authors.forename: S S
authors.initials: SS
authors.lastname: Hassan
authors.forename: M A
authors.initials: MA
authors.lastname: Ahmed
authors.forename: F S
authors.initials: FS
authors.lastname: Tadros