title: Actin-aggregating cucurbitacins from Physocarpus capitatus.
abstract: Bioassay-guided fractionation of Physocarpus capitatus yielded two new cucurbitacins (3 and 4) along with the known cucurbitacin F (1) and dihydrocucurbitacin F (2). Preliminary mechanism of action studies indicate that the cucurbitacins cause actin aggregates and inhibit cell division.
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, and Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: Katherine N
authors.initials: KN
authors.lastname: Maloney
authors.forename: Masaki
authors.initials: M
authors.lastname: Fujita
authors.forename: Ulrike S
authors.initials: US
authors.lastname: Eggert
authors.forename: Frank C
authors.initials: FC
authors.lastname: Schroeder
authors.forename: Christine M
authors.initials: CM
authors.lastname: Field
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Mitchison
authors.forename: Jon
authors.initials: J
authors.lastname: Clardy
mesh_terms: D000199:Actins / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D054728:Cucurbitacins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D048749:Cytokinesis / Q000187:drug effects; D004330:Drosophila; D027824:Rosaceae / Q000737:chemistry*; D014315:Triterpenes
chemical_list: D000199:Actins; D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; C098578:dihydrocucurbitacin F; C453923:cucurbitacin F; D054728:Cucurbitacins