title: Low-dose aspirin in non-tubal IVF patients with previous failed conception: a prospective randomized double-blind placebo-controlled trial.
abstract: OBJECTIVE
  To analyze whether the administration of low-dose aspirin during IVF treatment improves the uterine blood flow and improves ongoing pregnancy rates for non-tubal factor IVF patients with previous failed conception.
  
  
  METHODS
  Prospective double-blind placebo-controlled trial.
  
  
  METHODS
  University fertility clinic.
  
  
  METHODS
  Non-tubal IVF patients with previous failed conception.
  
  
  METHODS
  Daily 100 mg aspirin or placebo throughout an IVF treatment with a long GnRH-agonist stimulation protocol.
  
  
  METHODS
  Ongoing pregnancy rate, pulsatility index of the uterine artery.
  
  
  RESULTS
  Of 169 patients, 84 were assigned to aspirin treatment and 85 to placebo treatment. In the aspirin group, 28 patients (35.4%) had an ongoing pregnancy, and in the placebo group, 26 patients (31.0%) had an ongoing pregnancy. Multilevel analyses showed that the pulsatility index of the uterine artery was not affected by aspirin or placebo treatment.
  
  
  CONCLUSIONS
  Low-dose aspirin administration during IVF treatment does not improve pregnancy rates of non-tubal factor IVF patients with previous failed conception, and it does not affect the arterial uterine blood flow.
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Medicine Free University Medical Center, Amsterdam, The Netherlands. Electronic address: mj.lambers@vumc.nl.
authors.forename: Marieke J
authors.initials: MJ
authors.lastname: Lambers
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Medicine Free University Medical Center, Amsterdam, The Netherlands.
authors.forename: Diederik A
authors.initials: DA
authors.lastname: Hoozemans
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Medicine Free University Medical Center, Amsterdam, The Netherlands.
authors.forename: Roel
authors.initials: R
authors.lastname: Schats
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Medicine Free University Medical Center, Amsterdam, The Netherlands.
authors.forename: Roy
authors.initials: R
authors.lastname: Homburg
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Medicine Free University Medical Center, Amsterdam, The Netherlands.
authors.forename: Cornelis B
authors.initials: CB
authors.lastname: Lambalk
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Medicine Free University Medical Center, Amsterdam, The Netherlands.
authors.forename: Peter G A
authors.initials: PGA
authors.lastname: Hompes
mesh_terms: D000328:Adult; D001158:Arteries / Q000187:drug effects / Q000502:physiology; D001241:Aspirin / Q000494:pharmacology / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D010064:Embryo Implantation; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D014599:Uterus / Q000098:blood supply / Q000187:drug effects
chemical_list: D010975:Platelet Aggregation Inhibitors; D001241:Aspirin