[Activity of error-prone DNA polymerase iota in different periods of house mouse Mus musculus ontogeny].
Analysis of incorrect activity of error-prone DNA polymerase iota in M. musculus ontogeny demonstrated considerable changes in its activity, which peaks in most organs during prenatal development and decreases in the adult body. We propose that the capacity of error-prone DNA polymerases to synthesize on damaged DNA regions is critical for the realization of rapidly changing genetic program in mammalian embryogenesis, which relieves the replication block and prevents cell death.
Makarova
A V
AV
Gening
L V
LV
Makarova
I V
IV
Tarantul
V Z
VZ
D000818:Animals; D016923:Cell Death / Q000502:physiology; D002642:Chick Embryo; D004249:DNA Damage / Q000502:physiology*; D004261:DNA Replication / Q000502:physiology*; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D004622:Embryo, Mammalian / Q000166:cytology / Q000201:enzymology*; D051379:Mice; D009928:Organ Specificity; D038081:Organogenesis / Q000502:physiology*; D000094769:DNA Polymerase iota
D004259:DNA-Directed DNA Polymerase; D000094769:DNA Polymerase iota