An optimization procedure for determination of indomethacin and acemethacin by differential pulse adsorptive stripping voltammetry. Application on urine samples.
Procedures for the determination of indomethacin and acemethacin by differential pulse adsorptive stripping voltammetry with a mercury electrode have been described and optimised. The selection and optimization of the experimental parameters was done using factorial and central composite designs. Indomethacin and acemethacin in urine were determined by this method with good results and without the need for tedious prior separation. For routine calibration and calculation of the 'capacity to detect', the robust regression method least median squares (LMS) has been proposed.
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Departamento de Quimica (Area de Quimica Analitica), Facultad de Ciencias, Universidad de Burgos, Pza. Misael Bañuelos, 09001 Burgos, Spain.
Julia Arcos
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Cruz Ortiz
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