Inhibition of cyclooxygenase 2 in mice increases production of g-csf and induces radioprotection.
Meloxicam, a selective inhibitor of cyclooxygenase 2, was tested to determine its ability to modulate hematopoiesis and to influence survival of mid-lethally gamma-irradiated mice. A single dose of meloxicam (20 mg/kg) administered to mice intraperitoneally 1 h before irradiation was shown to enhance serum levels of granulocyte colony-stimulating factor (G-CSF) during the first 24 h after irradiation, to elevate numbers of granulocytic precursor cells in bone marrow and granulocyte counts in peripheral blood on day 10 after irradiation, and to increase 30-day survival of these mice. The results provide new evidence for the protective ability of meloxicam administration to mice irradiated with mid-lethal doses and contribute to the understanding of the mechanisms of this meloxicam action by drawing attention to the possible role of increased endogenous G-CSF production.
Hofer
M
M
Laboratory of Experimental Hematology, Institute of Biophysics, v.v.i., Academy of Sciences of the Czech Republic, Brno, Czech Republic. hofer@ibp.cz
Pospísil
M
M
Holá
J
J
Vacek
A
A
Streitová
D
D
Znojil
V
V
D000818:Animals; D052246:Cyclooxygenase 2 Inhibitors / Q000494:pharmacology*; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis*; D006410:Hematopoiesis / Q000528:radiation effects; D008297:Male; D000077239:Meloxicam; D051379:Mice; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013843:Thiazines / Q000494:pharmacology*; D013844:Thiazoles / Q000494:pharmacology*
D052246:Cyclooxygenase 2 Inhibitors; D011837:Radiation-Protective Agents; D013843:Thiazines; D013844:Thiazoles; D016179:Granulocyte Colony-Stimulating Factor; D000077239:Meloxicam