title: Hepatocellular carcinoma with pharyngeal metastasis: report of a case.
abstract: We report a case of pharyngeal metastasis of hepatocellular carcinoma (HCC). Any oral cavity involvement of HCC, especially pharyngeal metastasis, is extremely rare. The resected specimen contained a pedunculated polypoid lesion and histological examination revealed an epithelial tumor with a trabecular growth pattern, covered with intact squamous mucosa. Immunohistochemical studies were positive for hepatocyte-specific antigen and alpha-fetoprotein. At the time of writing, the patient, a 73-year-old man, was alive but with multiple recurrent lesions in the remnant liver, 1 year after resection of the pharyngeal metastasis. Oral metastases should be treated surgically or endoscopically if possible for the symptomatic relief of oral discomfort, pain, and bleeding; however, the prognosis is generally poor.
authors.affiliation: Division of Gastroenterological Surgery, Chiba Cancer Center Hospital, 666-2 Nitona-cho, Chuo-ku, Chiba, 260-8717, Japan.
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Nagao
authors.forename: Akihiro
authors.initials: A
authors.lastname: Cho
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Osamu
authors.initials: O
authors.lastname: Kainuma
authors.forename: Hisashi
authors.initials: H
authors.lastname: Gunji
authors.forename: Akinari
authors.initials: A
authors.lastname: Miyazaki
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ozaki
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000556:secondary* / Q000628:therapy; D017115:Catheter Ablation; D016461:Chemoembolization, Therapeutic; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology* / Q000628:therapy; D008297:Male; D010610:Pharyngeal Neoplasms / Q000556:secondary* / Q000628:therapy