title: Vitamin C-lipid metabolites: uptake and retention and effect on plasma C-reactive protein and oxidized LDL levels in healthy volunteers.
abstract: BACKGROUND
  Previously, a novel formulation of vitamin C-lipid metabolites (PureWay-C) was shown to be more rapidly taken-up by human T-lymphocytes and more rapidly stimulate neurite outgrowth, fibroblast adhesion and inhibition of xenobiotic-induced T-cell hyperactivation. Here, PureWay-C serum levels were measured in healthy volunteers after oral supplementation. Plasma C-reactive protein and oxidized low density lipoprotein levels (LDL) were also measured.
  
  
  METHODS
  Healthy volunteers maintained a low vitamin C diet for 14 days and, following an overnight fast, received a single oral dose of (vitamin C) 1000 mg of either ascorbic acid (AA), calcium ascorbate (CaA), vitamin C-lipid metabolites (PureWay-C), or calcium ascorbate-calcium threonate-dehydroascorbate (Ester-C). Blood samples were collected immediately prior to the oral dose administration and at various times post ingestion. Twenty-four-hour urine collections were saved for oxalate and uric acid assays.
  
  
  RESULTS
  PureWay-C supplementation leads to the highest absolute serum vitamin C levels when compared to AA, CaA and Ester-C. PureWay-C provides a statistically significant greater serum level than calcium ascorbate at 1, 2, 4, and 6 hours post oral supplementation whereas Ester-C shows a less but slightly statistically significant increase at only 1 and 4 hours. Oral supplementation with PureWay-C also led to a greater reduction in plasma C-reactive protein and oxidized LDL levels compared to the other vitamin C formulations.
  
  
  CONCLUSIONS
  PureWay-C is more rapidly absorbed and leads to higher serum vitamin C levels and greater reduction of plasma levels of inflammatory and oxidative stress markers than other forms of vitamin C, including Ester-C.
authors.affiliation: Comprehensive HealthCare of Miami, LLC, Miami, FL 33174, USA. Innteam@aol.com
authors.forename: Dario
authors.initials: D
authors.lastname: Pancorbo
authors.forename: Carlos
authors.initials: C
authors.lastname: Vazquez
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Fletcher
mesh_terms: D000328:Adult; D001205:Ascorbic Acid / Q000097:blood / Q000494:pharmacology*; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006262:Health; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects*; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019815:Oxalic Acid / Q000652:urine; D014527:Uric Acid / Q000652:urine; D055815:Young Adult
chemical_list: D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D014527:Uric Acid; D002097:C-Reactive Protein; D019815:Oxalic Acid; D001205:Ascorbic Acid