title: Urea solid-state biosensor suitable for continuous dialysis control.
abstract: A solid state potentiometric biosensor for urea determination was assembled coupling a nonactin-based ISE without an internal solution with immobilized urease. The system proved to be useful for continuous monitoring of urea during dialysis treatment using the ultrafiltrate of blood as sample. A noticeable shift of potential occurred during the dialysis (probably due to continuous extraction of ionophore by the ultrafiltrate). Therefore a flow injection analysis assembly was necessary to control the shift of electrode potential.
authors.affiliation: Dipartimento de Sanita Pubblica, Epidemiologia e Chimica Analitica Ambientale, Sezione di Chimica Analitica, Via Gino Capponi 9, 50121 Firenze, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Zamponi
authors.forename: B
authors.initials: B
authors.lastname: Lo Cicero
authors.forename: M
authors.initials: M
authors.lastname: Mascini
authors.forename: L
authors.initials: L
authors.lastname: Della Ciana
authors.forename: S
authors.initials: S
authors.lastname: Sacco