Elective single embryo transfer: a 6-year progressive implementation of 784 single blastocyst transfers and the influence of payment method on patient choice.
OBJECTIVE
To evaluate efforts to reduce twin pregnancies through progressive implementation of elective single embryo transfer (eSET) among select patients over a 6-year period.


METHODS
Retrospective review.


METHODS
Private practice IVF center.


METHODS
Infertile women undergoing 15,418 consecutive IVF-ET cycles.


METHODS
IVF-ET, including blastocyst-stage eSET among select patients with good prognosis and high risk of multiple pregnancy.


METHODS
Pregnancy, multiple pregnancy, method of payment.


RESULTS
Pregnancy rates were similar for autologous eSET versus double-blastocyst transfer (65% vs. 63%), while twin rates were much lower (1% vs. 44%). For recipients of donor oocytes, pregnancy rates were slightly lower with eSET (63% vs. 74%), while twin rates were much lower (2% vs. 54%). There was no decrease in overall pregnancy rates, despite a dramatic rise in eSET use over time (1.5% to 8.6% of all autologous transfers and 2.0% to 22.5% of all transfers to donor oocyte recipients between 2002 and 2007). Overall singleton pregnancy rates increased, while twin pregnancy rates declined significantly over time. Use of eSET was significantly more common among patients with insurance coverage or who were participating in our Shared Risk money-back guarantee program.


CONCLUSIONS
Selective eSET use among good-prognosis patients can significantly reduce twin pregnancies without compromising pregnancy rates. Patients are more likely to choose eSET when freed from financial pressures to transfer multiple embryos.
Stillman
Robert J
RJ
Shady Grove Fertility Reproductive Science Center, Rockville, Maryland 20850, USA.
Richter
Kevin S
KS
Banks
Nicole K
NK
Graham
James R
JR
D000328:Adult; D017677:Age Distribution; D002755:Choice Behavior; D005260:Female; D005307:Fertilization in Vitro / Q000191:economics* / Q000706:statistics & numerical data*; D017048:Health Care Costs; D006801:Humans; D007247:Infertility, Female / Q000191:economics / Q000453:epidemiology / Q000628:therapy; D007348:Insurance, Health / Q000706:statistics & numerical data; D011247:Pregnancy; D018873:Pregnancy Rate; D018566:Pregnancy, High-Risk; D011272:Pregnancy, Multiple; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D056826:Single Embryo Transfer / Q000191:economics* / Q000706:statistics & numerical data*