Application of the Folin-Ciocalteau reagent to the determination of salbutamol in pharmaceutical preparations.
A method for the determination of salbutamol in both tablets and syrups is described. It utilizes the reduction of the Folin-Ciocalteau reagent by the phenolic group, monitoring the absorbance of the resulting complex at 760 nm. Results obtained are linear over the range 0-6 mug ml(-1) salbutamol. Coloring material was removed by anionexchange chromatography prior to analysis and there was no interference from sucrose, neutral flavorings or the common preservative sodium benzoate. This method appears suitable as a general assay for salbutamol.
Sadler
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NP
Department of Chemistry, University of the West Indies, Mona, Kingston 7, Jamaica.
Jacobs
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H