title: Keratoconus diagnosis with optical coherence tomography pachymetry mapping.
abstract: OBJECTIVE
  To detect abnormal corneal thinning in keratoconus using pachymetry maps measured by high-speed anterior segment optical coherence tomography (OCT).
  
  
  METHODS
  Cross-sectional observational study.
  
  
  METHODS
  Thirty-seven keratoconic eyes from 21 subjects and 36 eyes from 18 normal subjects.
  
  
  METHODS
  The OCT system operated at a 1.3 microm wavelength with a scan rate of 2000 axial scans per second. A pachymetry scan pattern (8 radials, 128 axial scans each; 10 mm diameter) centered at the corneal vertex was used to map the corneal thickness. The pachymetry map was divided into zones by octants and annular rings. Five pachymetric parameters were calculated from the region inside the 5 mm diameter: minimum, minimum-median, inferior-superior (I-S), inferotemporal-superonasal (IT-SN), and the vertical location of the thinnest cornea. The 1-percentile value of the normal group was used to define the diagnostic cutoff. Placido-ring-based corneal topography was obtained for comparison.
  
  
  METHODS
  The OCT pachymetric parameters and a quantitative topographic keratoconus index (keratometry, I-S, astigmatism, and skew percentage [KISA%]) were used for keratoconus diagnosis. Diagnostic performance was assessed by the area under the receiver operating characteristic (AROC) curve.
  
  
  RESULTS
  Keratoconic corneas were thinner. The pachymetric minimum averaged 452.6+/-60.9 microm in keratoconic eyes versus 546+/-23.7 microm in normal eyes. The 1-percentile cutoff was 491.6 microm. The thinnest location was inferiorly displaced in keratoconus (-805+/-749 microm vs -118+/-260 microm; cutoff, -716 microm). The thinning was focal (minimum-median: -95.2+/-41.1 microm vs -45+/-7.7 microm; cutoff, -62.6 microm). Keratoconic maps were more asymmetric (I-S, -44.8+/-28.7 microm vs -9.9+/-9.3 microm; cutoff, -31.3 microm; and IT-SN, -63+/-35.7 microm vs -22+/-11.4 microm; cutoff, -48.2 microm). Keratoconic eyes had a higher KISA% index (2641+/-5024 vs 21+/-19). All differences were statistically significant (t test, P<0.0001). Applying the diagnostic criteria of any 1 OCT pachymetric parameter below the keratoconus cutoff yielded an AROC of 0.99, which was marginally better (P = .09) than the KISA% topographic index (AROC, 0.91).
  
  
  CONCLUSIONS
  Optical coherence tomography pachymetry maps accurately detected the characteristic abnormal corneal thinning in keratoconic eyes. This method was at least as sensitive and specific as the topographic KISA.
  
  
  BACKGROUND
  Proprietary or commercial disclosure may be found after the references.
authors.affiliation: Center for Ophthalmic Optics and Lasers, Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California 99033, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: David M
authors.initials: DM
authors.lastname: Meisler
authors.forename: Maolong
authors.initials: M
authors.lastname: Tang
authors.forename: Ake T H
authors.initials: AT
authors.lastname: Lu
authors.forename: Vishakha
authors.initials: V
authors.lastname: Thakrar
authors.forename: Bibiana J
authors.initials: BJ
authors.lastname: Reiser
authors.forename: David
authors.initials: D
authors.lastname: Huang
mesh_terms: D003315:Cornea / Q000473:pathology*; D019781:Corneal Topography; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007640:Keratoconus / Q000175:diagnosis*; D008297:Male; D012372:ROC Curve; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000379:methods*