NFIX--one gene, two knockouts, multiple effects.
A previous knockout of the transcription factor gene nuclear factor IX (NFIX) in mice produced impaired development of the corpus callosum and severe skeletal defects. A recent paper in BMC Developmental Biology reports an apparently similar NFIX knockout that produced marked differences in phenotype, raising intriguing general questions about the possible causes of such differences in mouse knockouts.
Pekarik
Vladimir
V
Center of Regenerative Medicine in Barcelona, Doctor Aiguader 88, 08003 Barcelona, Spain.
Izpisua Belmonte
Juan Carlos
JC
D061085:Agenesis of Corpus Callosum; D000818:Animals; D001842:Bone and Bones / Q000002:abnormalities*; D020868:Gene Silencing; D006849:Hydrocephalus / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout; D051839:NFI Transcription Factors / Q000235:genetics*; D010012:Osteogenesis
D051839:NFI Transcription Factors; C497650:Nfix protein, mouse