title: First and second order derivative spectrophotometric determination of benzyl alcohol and diclofenac in pharmaceutical forms.
abstract: Diclofenac sodium is a drug with analgesic, antipyretic and anti-inflammatory properties. It is present in numerous pharmaceutical preparations. In injectable forms, it is usually accompanied by benzyl alcohol as an excipient, which is used as a blocking anesthetic (4%) and an antiseptic (4-10%). In this work spectrophotometric methodology was used in order to determine diclofenac and benzyl alcohol in injectable formulations by applying, on the one hand, the first-derivative method of crossing zero for diclofenac sodium and on the other, second derivative for benzyl alcohol. The results obtained show that this method has a significant advantage over other techniques and it is appropriate for routine pharmaceutical analysis.
authors.affiliation: Department of Pharmacy and Department of Chemistry, San Luis National University, Chacabuco 917, 5.700 San Luis, Argentina.
authors.forename: Y C
authors.initials: YC
authors.lastname: de Micalizzi
authors.forename: N B
authors.initials: NB
authors.lastname: Pappano
authors.forename: N B
authors.initials: NB
authors.lastname: Debattista