title: Clean synthesis and antibacterial activities of spiro[pyrimido[4,5-b]quinoline-5,5'-pyrrolo[2,3-d]pyrimidine]-pentaones.
abstract: A simple, clean and efficient method for the synthesis of spiro[pyrimido[4,5-b]quinoline-5,5'-pyrrolo[2,3-d]pyrimidine]-pentaone derivatives by condensation reaction of 6-amino-uracils and isatins in aqueous media is reported. These products were evaluated in vitro for their antibacterial activities.
authors.affiliation: Department of Chemistry, Shahid Beheshti University, Tehran, Iran.
authors.forename: Ramin
authors.initials: R
authors.lastname: Ghahremanzadeh
authors.forename: Seyyedeh Cobra
authors.initials: SC
authors.lastname: Azimi
authors.forename: Nader
authors.initials: N
authors.lastname: Gholami
authors.forename: Ayoob
authors.initials: A
authors.lastname: Bazgir
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D007510:Isatin / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D012995:Solubility; D012997:Solvents; D013055:Spectrophotometry, Infrared; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D014498:Uracil / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D006576:Heterocyclic Compounds, 4 or More Rings; D007202:Indicators and Reagents; D011743:Pyrimidines; D012997:Solvents; D013141:Spiro Compounds; D014498:Uracil; D007510:Isatin