title: Cylindradines A and B: novel bromopyrrole alkaloids from the marine sponge Axinella cylindratus.
abstract: The novel alkaloids cylindradines A and B were isolated from Axinella cylindratus, and their structures were elucidated by spectroscopic analyses. Stereochemistries of these compounds were determined by X-ray analysis. Cylindradines showed moderate inhibitory activity against the murine leukemia cell line P388.
authors.affiliation: Department of Molecular Science, Integrated Center for Sciences, Ehime University, 2-5 Bunkyo-cho, Matsuyama 790-8577, Japan. kuramoto@dpc.ehime-u.ac.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Kuramoto
authors.forename: Norimichi
authors.initials: N
authors.lastname: Miyake
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Ishimaru
authors.forename: Noboru
authors.initials: N
authors.lastname: Ono
authors.forename: Hidemitsu
authors.initials: H
authors.lastname: Uno
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D047089:Axinella / Q000737:chemistry*; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D011758:Pyrroles / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D011758:Pyrroles; C552501:cylindradine A; C552502:cylindradine B