Knockdown screens to knockout HIV-1.
Three recent screens use siRNAs to identify host genes that are critical for HIV-1 replication. These screens have uncovered hundreds of human genes not previously known to be commandeered by the virus during infection. Although some caveats remain, this screening approach opens up a new landscape of viral-host interactions for future exploration.
Goff
Stephen P
SP
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, HHSC 1310c, New York, NY 10032, USA. spg1@columbia.edu
D015967:Gene Expression Regulation, Viral; D005821:Genetic Techniques; D015658:HIV Infections / Q000235:genetics / Q000378:metabolism; D015497:HIV-1 / Q000235:genetics*; D054884:Host-Pathogen Interactions; D006801:Humans; D014779:Virus Replication