Cytotoxic triterpenoid saponins from the roots of Ardisia crenata.
Ardisiacrenoside I (1), a new triterpenoid pentasaccharide with an unusual glycosyl glycerol side chain, was isolated from Ardisia crenata together with five closely related triterpenoid saponins. Their structures were elucidated by a combination of mass spectrometry, IR, 1D, and 2D NMR spectroscopy. Their cytotoxic activities were evaluated against several different human tumor cell lines by the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) method.
Zheng
Zhong-Fei
ZF
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Ministry of Education), Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Bejing, China.
Xu
Jian-Fu
JF
Feng
Zi-Ming
ZM
Zhang
Pei-Cheng
PC
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D031644:Ardisia / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D014315:Triterpenes; C539034:ardisiacrenoside I