Applying intelligent computing techniques to modeling biological networks from expression data.
Constructing biological networks is one of the most important issues in systems biology. However, constructing a network from data manually takes a considerable large amount of time, therefore an automated procedure is advocated. To automate the procedure of network construction, in this work we use two intelligent computing techniques, genetic programming and neural computation, to infer two kinds of network models that use continuous variables. To verify the presented approaches, experiments have been conducted and the preliminary results show that both approaches can be used to infer networks successfully.
Lee
Wei-Po
WP
Department of Information Management, National Sun Yat-sen University, Kaohsiung, Chinese Taipei. wplee@mail.nsysu.edu.tw
Yang
Kung-Cheng
KC
D000465:Algorithms; D001185:Artificial Intelligence; D005075:Biological Evolution; D019295:Computational Biology; D020869:Gene Expression Profiling / Q000706:statistics & numerical data; D053263:Gene Regulatory Networks; D053858:Metabolic Networks and Pathways; D008954:Models, Biological; D005810:Multigene Family; D016571:Neural Networks, Computer; D020411:Oligonucleotide Array Sequence Analysis / Q000706:statistics & numerical data; D049490:Systems Biology