title: A study of changes in homocysteine levels during normal pregnancy and pre-eclampsia.
abstract: To find out changes in homocysteine levels that occur during normal pregnancy and pregnancy with pre-eclamptic toxaemia and also to find out correlation between homocysteine concentration and preeclamptic toxaemia a study was carried out among 90 women of which 30 were control which included normotensive non-pregnant women and the study group I comprised 30 pregnant normotensive women and the study group II comprised 30 pregnant women with pre-eclamptic toxaemia. Serum homocysteine was measured in all subjects using fluorescence polarisation immuno-assay. Control group had highest mean homocysteine levels while the study group I had least mean homocysteine levels (p < 0.001). Levels were significantly higher in subjects with BP > 146/100 mm Hg as compared to subjects with BP >140/90 and <146/100 mm Hg (p=0.017). There was significant difference between study group I and II at same gestational age. Hyperhomocysteinaemia was observed in pre-eclamptic females, also it was found that homocysteine levels were directly correlated with severity of pre-eclampsia.
authors.affiliation: Department of Obstetrics and Gynaecology, King George's Medical University, Lucknow.
authors.forename: Urmila
authors.initials: U
authors.lastname: Singh
authors.forename: H P
authors.initials: HP
authors.lastname: Gupta
authors.forename: R K
authors.initials: RK
authors.lastname: Singh
authors.forename: Manju
authors.initials: M
authors.lastname: Shukla
authors.forename: Ranjana
authors.initials: R
authors.lastname: Singh
authors.forename: Seema Sinha Nee
authors.initials: SS
authors.lastname: Mehrotra
authors.forename: Shweta
authors.initials: S
authors.lastname: Prasad
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D005454:Fluorescence Polarization; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood; D008429:Maternal Welfare; D018743:Perinatal Care; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D012307:Risk Factors; D055815:Young Adult
chemical_list: D006710:Homocysteine