Streptococcus equi bacteriophage SeP9 binds to group C carbohydrate but is not infective for the closely related S. zooepidemicus.
Streptococcus equi (S. equi subsp. equi) is widely believed to have evolved from an ancestral strain of S. zooepidemicus (S. equi subsp. zooepidemicus) based on high sequence homology. A striking difference is the absence of phage sequences from S. zooepidemicus. In this study we show that the receptor for SeP9, a temperate bacteriophage of S. equi, is the Lancefield group C carbohydrate. However, although SeP9 binds to group C carbohydrate from S. zooepidemicus, it appears not to replicate and produce plaques.
Tiwari
Raksha
R
M.H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40546, United States.
Timoney
John F
JF
D000818:Animals; D002241:Carbohydrates / Q000502:physiology; D002473:Cell Wall / Q000821:virology; D006734:Horse Diseases / Q000382:microbiology*; D006736:Horses; D008242:Lysogeny; D011991:Receptors, Virus / Q000502:physiology; D012680:Sensitivity and Specificity; D013290:Streptococcal Infections / Q000662:veterinary*; D013291:Streptococcus / Q000302:isolation & purification / Q000821:virology; D017108:Streptococcus Phages / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D018502:Streptococcus equi / Q000821:virology*; D014779:Virus Replication
D002241:Carbohydrates; D011991:Receptors, Virus