title: Economic evaluation of coronary artery bypass grafting surgery with and without cardiopulmonary bypass: cost-effectiveness and quality-adjusted life years in a randomized controlled trial.
abstract: The objective of this study is to evaluate the costs and health benefits of coronary artery bypass grafting (CABG) surgery with and without cardiopulmonary bypass (CPB). Randomized controlled clinical trial is used as the design. The setting is in a single tertiary cardiothoracic center in Middlesex, UK. Participants were 168 patients (27 females) requiring primary isolated CABG surgery. Patients were randomized to have the procedure performed by a single surgeon either with CPB (n = 84) or by an off-pump coronary artery bypass (OPCAB) surgery (n = 84). Health-related quality of life was assessed at baseline, 6 weeks, and 6 months using the World Health Organization Quality-of-Life (WHOQOL-100) questionnaire. Mean total costs of patient management by either technique were calculated using different available key sources. A utility measure, derived from WHOQOL-100, was used to calculate quality-adjusted life year (QALY) gained in each group, on basis of which a cost-effectiveness analysis was performed. The mean total costs of an OPCAB patient was 5859 pounds , whereas for a CPB patient it was 7431 pounds with a mean difference of 1572 pounds (standard error [SE] 674 pounds ; P = 0.02). Three patients died in the CPB group and two in the OPCAB group during the 6-month follow-up period. Mean QALYs over 6 months was 0.379 in the OPCAB group and 0.362 in the CPB group, but the difference was not significant (mean difference 0.017; SE 0.016; P = 0.305). OPCAB surgery offered patients in this randomized trial similar health benefits to CPB over a 6-month period, but at a significantly less cost.
authors.affiliation: National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, Harefield Hospital, Middlesex, UK. sharifalruzzeh@yahoo.co.uk
authors.forename: Sharif
authors.initials: S
authors.lastname: Al-Ruzzeh
authors.forename: David
authors.initials: D
authors.lastname: Epstein
authors.forename: Shane
authors.initials: S
authors.lastname: George
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Bustami
authors.forename: Jo
authors.initials: J
authors.lastname: Wray
authors.forename: Charles
authors.initials: C
authors.lastname: Ilsley
authors.forename: Mark
authors.initials: M
authors.lastname: Sculpher
authors.forename: Mohamed
authors.initials: M
authors.lastname: Amrani
mesh_terms: D002315:Cardiopulmonary Bypass / Q000191:economics*; D047549:Coronary Artery Bypass, Off-Pump / Q000191:economics*; D003362:Cost-Benefit Analysis; D005260:Female; D006305:Health Status Indicators; D017721:Hospital Costs; D006760:Hospitalization / Q000191:economics; D006801:Humans; D010359:Patient Readmission / Q000191:economics; D011182:Postoperative Care / Q000191:economics; D011788:Quality of Life; D019057:Quality-Adjusted Life Years; D016896:Treatment Outcome