title: [Effect of anti-influenza virus H3N2 of Hypericum japonicum in vivo].
abstract: OBJECTIVE
  To investigate anti-influenza virus H3N2 effect of Hypericum japonicum in vivo.
  
  
  METHODS
  The influences on lung index and death rate were observed in the mice infected with virus H3N2 from intranasal.
  
  
  RESULTS
  Experiments in vivo showed that Hypericum japonicum at the concentration of 10 g/kg x d for the intranasal treatment markedly inhibited the lung consolidation of mice pneumonia caused by the infection of influenza virus H3N2 and prolonged the survival time .
  
  
  CONCLUSIONS
  Hypericum japonicum may be effective on treating influenza.
authors.affiliation: Tropical Medicine Institute Guangzhou University of Chinese Medicine, Guangzhou 51043, China.
authors.forename: Ni
authors.initials: N
authors.lastname: Liu
authors.forename: Xi-Liu
authors.initials: XL
authors.lastname: Hu
authors.forename: Yi-Rong
authors.initials: YR
authors.lastname: Meng
authors.forename: Yu-Tong
authors.initials: YT
authors.lastname: Zhu
authors.forename: Bi-Song
authors.initials: BS
authors.lastname: Huang
authors.forename: Pei-Zheng
authors.initials: PZ
authors.lastname: Lin
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D020902:Hypericum / Q000737:chemistry*; D053122:Influenza A Virus, H3N2 Subtype / Q000187:drug effects*; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000188:drug therapy* / Q000473:pathology / Q000821:virology; D010946:Plants, Medicinal / Q000737:chemistry; D011024:Pneumonia, Viral / Q000473:pathology; D011897:Random Allocation; D012254:Ribavirin / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D012254:Ribavirin