In vitro evidence that commercial influenza vaccines are not similar in their ability to activate human T cell responses.
We evaluated three commercial trivalent inactivated vaccines (TIVs) from the 2007-2008 season in terms of their ability to elicit in vitro T cell responses. T cell-mediated immunity may offer a more cross-reactive vaccine approach for the prevention of pandemic or epidemic influenza. Human cytotoxic T cell lines demonstrated differences in matrix protein 1 and nucleocapsid protein recognition of autologous target cells. Peripheral blood mononuclear cells stimulated with each of the TIVs showed statistically significant differences between the vaccines in the numbers of IFNgamma producing cells activated. These data suggest that TIV vaccines are not similar in their ability to activate human T cell responses.
Co
Mary Dawn T
MD
Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA. mary.co@umassmed.edu
Orphin
Laura
L
Cruz
John
J
Pazoles
Pamela
P
Green
Karin M
KM
Potts
James
J
Leporati
Anita M
AM
Babon
Jenny Aurielle B
JA
Evans
James E
JE
Ennis
Francis A
FA
Terajima
Masanori
M
D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002460:Cell Line; D016207:Cytokines / Q000096:biosynthesis; D004345:Drug Industry; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology; D053122:Influenza A Virus, H3N2 Subtype / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D007371:Interferon-gamma / Q000096:biosynthesis; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D019590:Nucleocapsid Proteins / Q000276:immunology / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology*; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology*; D014763:Viral Matrix Proteins / Q000276:immunology / Q000378:metabolism
D016207:Cytokines; D007252:Influenza Vaccines; C488936:M1 protein, Influenza A virus; D019590:Nucleocapsid Proteins; D015164:Vaccines, Inactivated; D014763:Viral Matrix Proteins; D007371:Interferon-gamma