title: Recanalization strategy for chronic total occlusions with tapered and stiff-tip guidewire. The results of CTO new techniQUE for STandard procedure (CONQUEST) trial.
abstract: BACKGROUND
  The success rate of percutaneous coronary intervention (PCI) for chronic total coronary occlusion (CTO) lesions varies depending on the guidewire manipulation skills of the operator. The standardization of guidewire technique is very important. A new technique with a new tapered wire (Conquest, Confianza Pro) was tested to verify effectiveness for higher initial success rates and standardization of PCI for CTO.
  
  
  METHODS
  A prospective, multicenter registry was conducted at 6 investigational sites. In the CONQUEST trial, The CTO lesions were treated by using an intermediate guidewire to cross the lesion. If it did not cross, the guidewire was changed to the Conquest guidewire. If it did not cross, "seesaw-wiring" or the "parallel-wire technique" was performed. The primary endpoint was the initial procedural success rate.
  
  
  RESULTS
  A total of 110 patients representing 116 CTO lesions were treated from July 2003 through March 2004. The procedural success rate was 86.2% on the first try, and 88.8% on the second try, respectively. The guidewire success rate on the second try was 90.5% during the hospital stay; no deaths, or acute myocardial infarctions were confirmed. Two patients deteriorated into tamponade, and surgical or percutaneous drainage was performed in each patient without any sequelae.
  
  
  CONCLUSIONS
  A guidewire technique in PCI for CTOs that starts with the intermediate guidewire and moves to the Confianza Pro tapered guidewire, either alone or by performing a see-saw or parallel-wire technique, can achieve a high initial success rate with an acceptably low major complication rate.
authors.affiliation: Department of Cardiology, Kurashiki Central Hospital, 1-1-1 Miwa, Kurashiki, Okayama, 710-8602, Japan. km2131@kchnet.or.jp
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Mitsudo
authors.forename: Takehiro
authors.initials: T
authors.lastname: Yamashita
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Asakura
authors.forename: Toshiya
authors.initials: T
authors.lastname: Muramatsu
authors.forename: Osamu
authors.initials: O
authors.lastname: Doi
authors.forename: Yoshisato
authors.initials: Y
authors.lastname: Shibata
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Morino
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation* / Q000379:methods*; D002908:Chronic Disease; D054059:Coronary Occlusion / Q000628:therapy*; D004867:Equipment Design; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome