Heritability and linkage study on heart rates in a Mongolian population.
Elevated heart rate has been proposed as an independent risk factor for cardiovascular diseases, but their interrelationships are not well understood. In this study, we performed a genome-wide linkage scan in 1,026 individuals (mean age 30.6 years, 54.5% women) from 73 extended families of Mongolia and determined quantitative trait loci that influence heart rate. The DNA samples were genotyped using deCODE 1,039 microsatellite markers for 3 cM density genome-wide linkage scan. Correlation analysis was carried out to evaluate the correlation of the covariates and the heart rate. T-tests of the heart rate were also performed on sex, smoking and alcohol intake. Consequently, this model was used in a nonparametric genome-wide linkage analysis using variance component model to create a multipoint logarithm of odds (LOD) score and a corresponding P value. In the adjusted model, the heritability of heart rate was estimated as 0.32 (P<.0001) and a maximum multipoint LOD score of 2.03 was observed in 77 cM region at chromosome 18. The second largest LOD score of 1.52 was seen on chromosome 5 at 216 cM. Genes located on the specified locations in chromosomes 5 and 18 may be involved in the regulation of heart rate.
Gombojav
Bayasgalan
B
Department of Public Health, The Graduate School, Yonsei University, Seoul 120-752, Korea.
Park
Hansoo
H
Kim
Jong Il
JI
Ju
Young Seok
YS
Sung
Joohon
J
Cho
Sung Il
SI
Lee
Mi Kyeong
MK
Ohrr
Heechoul
H
Radnaabazar
Janchiv
J
Seo
Jeong Sun
JS
D000293:Adolescent; D000328:Adult; D002874:Chromosome Mapping / Q000379:methods*; D005260:Female; D008040:Genetic Linkage; D005828:Genetics, Population; D015894:Genome, Human / Q000235:genetics*; D055106:Genome-Wide Association Study / Q000379:methods; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D008986:Mongolia; D040641:Quantitative Trait Loci / Q000235:genetics*; D055815:Young Adult