A protein-only RNase P in human mitochondria.
In bacteria, archaea, and the eukaryote nucleus, the endonuclease ribonuclease P (RNase P) is composed of a catalytic RNA that is assisted by protein subunits. Holzmann et al. (2008) now provide evidence that the human mitochondrial RNase P is an entirely protein-based enzyme.
Walker
Scott C
SC
Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109-0606, USA.
Engelke
David R
DR
D019143:Evolution, Molecular; D006801:Humans; D008928:Mitochondria / Q000201:enzymology*; D016337:RNA, Catalytic / Q000032:analysis*; D043262:Ribonuclease P / Q000737:chemistry* / Q000378:metabolism
D016337:RNA, Catalytic; D043262:Ribonuclease P