title: Withanolide Z, a new chlorinated withanolide from Withania somnifera.
abstract: Reverse-phase preparative HPLC analysis of the n-butanol fraction of the methanolic extract of Withania somnifera Dunal (leaves) afforded a novel chlorinated withanolide, namely withanolide Z (1), along with four known withanolides, withanolide B (2), withanolide A (3), 27-hydroxywithanolide B (4) and withaferin A (5). Their structures were elucidated by IR, MS, CD and a combination of 1 D and 2 D NMR spectral analyses. The Leishmania donovani DNA topoisomerase I inhibitory activities of the isolated compounds were determined.
authors.affiliation: Medicinal Chemistry Division, Indian Institute of Chemical Biology, Jadavpur, Kolkata, India.
authors.forename: Swapan
authors.initials: S
authors.lastname: Pramanick
authors.forename: Amit
authors.initials: A
authors.lastname: Roy
authors.forename: Shekher
authors.initials: S
authors.lastname: Ghosh
authors.forename: Hemanta K
authors.initials: HK
authors.lastname: Majumder
authors.forename: Sibabrata
authors.initials: S
authors.lastname: Mukhopadhyay
mesh_terms: D000818:Animals; D007893:Leishmania donovani / Q000201:enzymology; D015394:Molecular Structure; D059004:Topoisomerase I Inhibitors; D032341:Withania / Q000737:chemistry*; D054358:Withanolides / Q000737:chemistry*
chemical_list: D059004:Topoisomerase I Inhibitors; D054358:Withanolides; C534198:withanolide Z