Patient attitudes toward genotyping in an urban women's health clinic.
OBJECTIVE
To estimate willingness of women to donate specimens for DNA analysis by needlestick compared with collection of saliva.


METHODS
This study was a cross-sectional survey given to women attending clinic appointments asked about their knowledge and attitudes toward genetics research and genotyping.


RESULTS
The majority of the 279 women surveyed would give DNA specimens by needlestick (68.3%) but more would be willing to donate saliva (75.7%), P=.003. An ethnic difference was seen in the replies about needlesticks but not regarding saliva donation. Multivariable analysis demonstrated that women who were likely to donate specimens rated themselves more knowledgeable about genes and DNA (odds ratio 2.43, 95% confidence interval 1.12-5.28) and had graduated from college or higher (odds ratio 6.74, 95% confidence interval 1.98-22.86).


CONCLUSIONS
More women are willing to donate DNA specimens by saliva than by needlestick. Knowledge and higher education predict a willingness to donate.


METHODS
III.
Haas
David M
DM
Department of Obstetrics and Gynecology, Division of Clinical Pharmacology, Indiana University Center for Bioethics, Indiana University School of Medicine, and Wishard Hospital, Indianapolis, Indiana 46202, USA. dahaas@iupui.edu
Renbarger
Jamie L
JL
Meslin
Eric M
EM
Drabiak
Katherine
K
Flockhart
David
D
D000293:Adolescent; D000328:Adult; D003430:Cross-Sectional Studies; D004247:DNA / Q000032:analysis* / Q000097:blood; D003625:Data Collection; D005260:Female; D005838:Genotype; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D018962:Phlebotomy; D011247:Pregnancy; D012463:Saliva / Q000737:chemistry; D013048:Specimen Handling / Q000379:methods*; D055815:Young Adult
D004247:DNA