title: Comparative toxicity to mice of domoic acid and isodomoic acids A, B and C.
abstract: Seafood in many parts of the world may become contaminated with high levels of domoic acid and domoic acid isomers, and such seafood has been shown to cause toxic effects in humans and in marine animals. Domoic acid itself has been held responsible for the observed effects, although the possible contribution of the isomers to toxicity has not been investigated. In the present study, the acute intraperitoneal toxicity of isodomoic acid C in mice was found to be lower than that of domoic acid. Furthermore, the severities of the behavioural changes induced by isodomoic acids A, B and C were all much lower than that of domoic acid itself, suggesting that these substances pose relatively little risk to human or animal health.
authors.affiliation: AgResearch, Ruakura Research Centre, Private Bag 3123, Hamilton, New Zealand. rex.munday@agresearch.co.nz
authors.forename: Rex
authors.initials: R
authors.lastname: Munday
authors.forename: Patrick T
authors.initials: PT
authors.lastname: Holland
authors.forename: Paul
authors.initials: P
authors.lastname: McNabb
authors.forename: Andrew I
authors.initials: AI
authors.lastname: Selwood
authors.forename: Lesley L
authors.initials: LL
authors.lastname: Rhodes
mesh_terms: D000818:Animals; D001519:Behavior / Q000187:drug effects; D005260:Female; D006538:Heptanoic Acids / Q000302:isolation & purification / Q000633:toxicity*; D007274:Injections, Intraperitoneal; D007536:Isomerism; D007608:Kainic Acid / Q000031:analogs & derivatives* / Q000633:toxicity; D007928:Lethal Dose 50; D008387:Marine Toxins / Q000302:isolation & purification / Q000633:toxicity*; D051379:Mice; D008958:Models, Molecular; D049880:Mytilus edulis / Q000378:metabolism; D049897:Pectinidae / Q000737:chemistry; D012624:Seaweed / Q000737:chemistry
chemical_list: D006538:Heptanoic Acids; D008387:Marine Toxins; C524833:isodomoic acid A; C504322:isodomoic acid C; C012301:domoic acid; D007608:Kainic Acid