title: A case of primary hypothyroidism causing central nervous system atherosclerosis in a dog.
abstract: A 2-year-old, castrated male, Australian shepherd was presented with a history of chronic mild ataxia, obesity, and lethargy. The dog was treated with levothyroxine, but the ataxia worsened. Cranial nerve abnormalities developed and the dog was euthanized. Postmortem examination revealed marked thyroid gland atrophy and widespread, severe central nervous system atherosclerosis.
authors.affiliation: Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Ontario N1G 2W1. sblois@uoguelph.ca
authors.forename: Shauna L
authors.initials: SL
authors.lastname: Blois
authors.forename: Roberto
authors.initials: R
authors.lastname: Poma
authors.forename: Margaret J
authors.initials: MJ
authors.lastname: Stalker
authors.forename: Dana G
authors.initials: DG
authors.lastname: Allen
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology; D004285:Dogs; D017809:Fatal Outcome; D007037:Hypothyroidism / Q000150:complications / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D002537:Intracranial Arteriosclerosis / Q000175:diagnosis / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D008297:Male; D013961:Thyroid Gland / Q000473:pathology*