[Low-dose flutamide in the treatment of hyperandrogenism in adolescents].
OBJECTIVE
The aim of the study was to evaluate the results of the use of flutamide at low doses for the therapy of the iperandrogenism in adolescents.


METHODS
The study enrolled 35 young women with acne and irsutism; 31 had polycystic ovary syndrome (PCOS) and 4 periferic iperandrogenism. In other 8 young women, sexually active, the flutamide has been associated with the hormonal contraceptive. On the three young women with iperinsulinism it has been decided to associate the flutamide with the metformina. All the young women were checked each month for the liver functional. Before the beginning of the therapy the menstrual situation, the Body Mass Index (BMI), the Ferriman' s and Cremoncini's score, the ovary's ultrasound aspect, and the hormonal order were evaluated. Follow-up was made after three months and after six months after the beginning of the therapy with flutamide 62.5 mg/die.


RESULTS
Only in 4 cases the therapy has been suspended due to collateral effects, soon regressed after one week of the treatment interruption. The results have demonstrated a overwhelming improvement of the peripheral symptoms of iperandrogenism in all patients.


CONCLUSIONS
The authors hope that flutamide could enter in the list of medicines normally used to treat the beauty flaws of policistic acne and to restore a hormonal order associated to an effective contraception.
Pizzo
A
A
Dipartimento di Scienze Ginecologiche e Ostetriche, Facoltà di Medicina e Chirurgia, Università degli Studi di Messina, Messina, Italia alfonsa.pizzo@tin.it
Borrielli
I
I
Mastroeni
M T
MT
Fattori
A
A
Dugo
C
C
Dugo
N
N
Dinatale
A
A
D000152:Acne Vulgaris / Q000188:drug therapy*; D000293:Adolescent; D000726:Androgen Antagonists / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D015992:Body Mass Index; D002648:Child; D005260:Female; D005485:Flutamide / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006628:Hirsutism / Q000188:drug therapy*; D006801:Humans; D017588:Hyperandrogenism / Q000188:drug therapy*; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy*; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
D000726:Androgen Antagonists; D005485:Flutamide