title: The prognostic value of molecular biomarkers in tissue removed by curettage from FIGO stage 1 and 2 endometrioid type endometrial cancer.
abstract: OBJECTIVE
  To analyze the prognostic value of molecular biomarkers in curettages of endometrioid endometrial cancer pathologic FIGO stages 1 and 2.
  
  
  METHODS
  Population-based survival analysis in 258 patients of classical prognostic features and molecular biomarkers of cell cycle regulation, (anti)apoptosis, proliferation, squamous differentiation, and PTEN/Akt pathway.
  
  
  RESULTS
  With 74 months median follow-up (range, 1-209), 24 (9.3%) patients had metastases develop. Pathologic FIGO stage 2B (6% of all cases) and age > 68 years had independent multivariate prognostic value. Many molecular biomarkers were prognostic, particularly cell-cycle regulators p16, p21, p27, p53, p63, and the antiapoptosis marker survivin (which mostly stains mitoses). The strong prognostic value of a multivariate model with survivin, p21, and p53 overshadowed all other prognosticators in pathologic FIGO 1 and 2A.
  
  
  CONCLUSIONS
  In pathologic FIGO stage 1 and 2A endometrioid endometrial cancer curettages, combined biomarkers survivin, p21, and p53 expression patterns are prognostically stronger than classical feature combinations.
authors.affiliation: Department of Pathology, Stavanger University Hospital, Stavanger, Norway.
authors.forename: Anita
authors.initials: A
authors.lastname: Steinbakk
authors.forename: Ivar
authors.initials: I
authors.lastname: Skaland
authors.forename: Einar
authors.initials: E
authors.lastname: Gudlaugsson
authors.forename: Emiel A M
authors.initials: EA
authors.lastname: Janssen
authors.forename: Kjell H
authors.initials: KH
authors.lastname: Kjellevold
authors.forename: Jan
authors.initials: J
authors.lastname: Klos
authors.forename: Kjell
authors.initials: K
authors.lastname: Løvslett
authors.forename: Bent
authors.initials: B
authors.lastname: Fiane
authors.forename: Jan P A
authors.initials: JP
authors.lastname: Baak
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D018269:Carcinoma, Endometrioid / Q000737:chemistry* / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D003475:Curettage; D016889:Endometrial Neoplasms / Q000737:chemistry* / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009367:Neoplasm Staging; D051058:Oncogene Protein v-akt / Q000032:analysis; D051059:PTEN Phosphohydrolase / Q000032:analysis; D011237:Predictive Value of Tests; D046888:Tissue Array Analysis
chemical_list: D014408:Biomarkers, Tumor; D051058:Oncogene Protein v-akt; D051059:PTEN Phosphohydrolase