title: Boron neutron capture therapy for newly diagnosed glioblastoma.
abstract: We evaluate the clinical results of a form of tumor selective particle radiation known as boron neutron capture therapy (BNCT) for newly-diagnosed glioblastoma (NDGB) patients, especially in combination with X-ray treatment (XRT). Between 2002 and 2006, we treated 21 patients of NDGB with BNCT utilizing sodium borocaptate and boronophenylalanine simultaneously. The first 10 were treated with only BNCT (protocol 1), and the last 11 were treated with BNCT followed by XRT of 20 to 30 Gy (protocol 2) to reduce the possibility of local tumor recurrence. No chemotherapy was applied until tumor progression was observed. The patients treated with BNCT (protocol 1 plus 2) showed a significant survival prolongation compared with the institutional historical controls. BNCT also showed favorable results in correspondence with the RTOG- and EORTC-RPA subclasses. The median survival time (MST) was 15.6 months for protocols 1 and 2 together. For protocol 2, the MST was 23.5 months. The main causes of death were cerebrospinal fluid dissemination as well as local recurrence. Our modified BNCT protocol showed favorable results of patients with NDGB not only for those with good prognoses but also for those with poor prognoses.
authors.affiliation: Department of Neurosurgery, Osaka Medical College, Takatsuki, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Kawabata
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Miyatake
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Kuroiwa
authors.forename: Kunio
authors.initials: K
authors.lastname: Yokoyama
authors.forename: Atsushi
authors.initials: A
authors.lastname: Doi
authors.forename: Kyoko
authors.initials: K
authors.lastname: Iida
authors.forename: Shiro
authors.initials: S
authors.lastname: Miyata
authors.forename: Naosuke
authors.initials: N
authors.lastname: Nonoguchi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Michiue
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Takahashi
authors.forename: Taisuke
authors.initials: T
authors.lastname: Inomata
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Imahori
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Kirihata
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Sakurai
authors.forename: Akira
authors.initials: A
authors.lastname: Maruhashi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kumada
authors.forename: Koji
authors.initials: K
authors.lastname: Ono
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D001932:Brain Neoplasms / Q000175:diagnosis / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D005260:Female; D005909:Glioblastoma / Q000175:diagnosis / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult