Role for adhesion molecules in the spermatogonial stem cell niche.
In this issue of Cell Stem Cell, Kanatsu-Shinohara et al. (2008) show that beta1-integrin participates in normal spermatogenesis and is required for spermatogonial stem cell (SSC) homing to the basal membrane niche. The methodology used provides a powerful tool to study the role of other factors in niche-SSC interactions.
de Rooij
Dirk G
DG
Center for Reproductive Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands. d.g.derooij@uu.nl
Repping
S
S
van Pelt
Ans M M
AM
D000818:Animals; D001814:Blood-Testis Barrier / Q000502:physiology; D002448:Cell Adhesion / Q000502:physiology*; D002454:Cell Differentiation; D002465:Cell Movement; D006706:Homeostasis; D019012:Integrin beta1 / Q000378:metabolism*; D008297:Male; D051379:Mice; D011485:Protein Binding; D013091:Spermatogenesis / Q000502:physiology*; D013093:Spermatogonia / Q000166:cytology / Q000378:metabolism*; D055153:Stem Cell Niche / Q000166:cytology* / Q000502:physiology; D033581:Stem Cell Transplantation; D013737:Testis / Q000166:cytology / Q000254:growth & development
D019012:Integrin beta1