Simultaneous determination of acetaminophen and caffeine in tablet preparations by partial least-squares multivariate spectrophotometric calibration.
The use of partial least-squares spectrophotometric calibration for the simultaneous determination of analgesic tablets in a multicomponent formulation is presented. This method is applied to the determination of acetaminophen and caffeine in tablet preparations. The results show that these components in a molar ratio of about 21:1 in tablets have been determined simultaneously with high precision.
Bozdogan
A
A
Yildiz University, Department of Chemistry, Sişli, Istanbul, Turkey.
Acar
A M
AM
Kunt
G K
GK