title: Novel synthetic luteolin analogue-caused sensitization of tumor necrosis factor-alpha-induced apoptosis in human tumor cells.
abstract: Studies on the sensitization, by novel alkynyl luteolin analogues, of TNF-alpha-induced apoptosis in HeLa and HepG2 cells revealed that LA-12 showed better sensitizing effects on TNF-alpha-induced cell death than luteolin, suggesting great potential for alkynyl luteolin analogues in cancer therapy.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543, Republic of Singapore.
authors.forename: Lili
authors.initials: L
authors.lastname: Cheng
authors.forename: Huiling
authors.initials: H
authors.lastname: Tan
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Wu
authors.forename: Ruijun
authors.initials: R
authors.lastname: Hu
authors.forename: Carlin
authors.initials: C
authors.lastname: Aw
authors.forename: Min
authors.initials: M
authors.lastname: Zhao
authors.forename: Han-Ming
authors.initials: HM
authors.lastname: Shen
authors.forename: Yixin
authors.initials: Y
authors.lastname: Lu
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D015195:Drug Design; D006801:Humans; D047311:Luteolin / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009369:Neoplasms / Q000473:pathology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D014409:Tumor Necrosis Factor-alpha; D047311:Luteolin