title: [Testicular cancer - explanatory models for high cisplatin chemosensibility and new therapeutic options].
abstract: This article offers a review about the current facts of chemotherapy in testicular cancer. Besides a short presentation of the guideline-standard therapy the authors deal with the question as to why testicular cancer shows an extraordinarily high chemosensibility compared to other tumours. Furthermore, the current data on alternative chemotherapies as well as of molecular, molecular-genetic and pharmacogenetic therapeutic concepts are explored. Data were obtained from researches in Medline of the Pubmed database.
authors.affiliation: Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin. jan.ebbing@charite.de
authors.forename: J
authors.initials: J
authors.lastname: Ebbing
authors.forename: F
authors.initials: F
authors.lastname: Christoph
authors.forename: C
authors.initials: C
authors.lastname: Kempkensteffen
authors.forename: S
authors.initials: S
authors.lastname: Weikert
authors.forename: M
authors.initials: M
authors.lastname: Schostak
authors.forename: S
authors.initials: S
authors.lastname: Hinz
authors.forename: M
authors.initials: M
authors.lastname: Lein
authors.forename: K
authors.initials: K
authors.lastname: Miller
authors.forename: M
authors.initials: M
authors.lastname: Schrader
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D003546:Cysteine Endopeptidases / Q000235:genetics; D004260:DNA Repair / Q000187:drug effects / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D004305:Dose-Response Relationship, Drug; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D004720:Endonucleases / Q000235:genetics; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy* / Q000235:genetics / Q000401:mortality / Q000473:pathology; D011110:Polymorphism, Genetic / Q000235:genetics; D017410:Practice Guidelines as Topic; D015996:Survival Rate; D013736:Testicular Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000401:mortality / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
chemical_list: D004268:DNA-Binding Proteins; D016159:Tumor Suppressor Protein p53; C071447:ERCC1 protein, human; D004720:Endonucleases; D003546:Cysteine Endopeptidases; C031262:bleomycin hydrolase; D002945:Cisplatin