title: Influence of fibrinogen beta-chain gene variations on risk of myocardial infarction in a Chinese Han population.
abstract: BACKGROUND
  Although the role of fibrinogen as a predictor of acute myocardial infarction (MI) has been well-established, the association of genetic polymorphisms in the fibrinogen gene with MI is still controversial. This study was conducted to elucidate the association between the genetic polymorphisms of the fibrinogen beta-chain (FGB) gene and MI in Chinese Han population.
  
  
  METHODS
  The occurrence of 3 common polymorphisms (i.e., -455G/A, R448K and 8558C/G) in a case-control study including 508 patients with MI and 503 healthy controls was investigated. Results Analyses of single polymorphisms showed that individuals carrying the rare alleles for the 3 polymorphisms were significantly associated with a decreased risk of MI. Logistic regression analysis indicated that R448K remained independently associated with MI after adjustment for environmental risk factors (adjusted odds ratio(OR) = 0.71 for KK/RK versus RR, P = 0.023). The three polymorphisms were found to be in strong linkage disequilibrium. Haplotype analyses showed that the A-K-G haplotype (-455A, 448K, 8558G) was associated with a protective effect against MI. Compared with the common haplotype G-R-C, the adjusted OR for A-K-G was 0.68 (95% CI, 0.51-0.90; P = 0.006).
  
  
  CONCLUSIONS
  These data indicate that individuals carrying the FGB 448K allele may be protective against having MI in this population.
authors.affiliation: Department of Evidence Based Medicine and Division of Population Genetics, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
authors.forename: Xiang-feng
authors.initials: XF
authors.lastname: Lu
authors.forename: Hong-jiang
authors.initials: HJ
authors.lastname: Yu
authors.forename: Xiao-yang
authors.initials: XY
authors.lastname: Zhou
authors.forename: Lai-yuan
authors.initials: LY
authors.lastname: Wang
authors.forename: Jian-feng
authors.initials: JF
authors.lastname: Huang
authors.forename: Dong-feng
authors.initials: DF
authors.lastname: Gu
mesh_terms: D000328:Adult; D000368:Aged; D002681:China / Q000208:ethnology; D005260:Female; D005340:Fibrinogen / Q000235:genetics*; D014644:Genetic Variation; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D005340:Fibrinogen