Titrimetric Microdetermination of chloral hydrate by amplification reactions.
A simple titrimetric method for estimation of 0.1-5 mg of chloral hydrate is presented. It depends on oxidation of an alkaline solution of chloral hydrate with a chloroform solution of iodine, removal of excess of iodine, oxidation of the resulting iodide with bromine, and iodometric titration of the iodate produced, giving 6-fold amplification. Alternatively, the iodide formed is oxidized with periodate, masking of the excess of periodate with molybdate at pH 3, and iodometric titration of the iodate, giving 24-fold amplification. The coefficient of variation does not usually exceed 2%, for above 1 mg of chloral hydrate but increases to 3.8% at the 0.1-mg level.
Amin
D
D
Department of Chemistry, College of Science, Mosul University, Mosul, Iraq.
Al-Ajely
M S
MS