title: Studies of the thiadiazine, taurolidine-I. Identification of the molecular species present in aqueous solutions by (1)H- and (13)C-NMR spectroscopy.
abstract: The equilibria in deuterium oxide solutions of the diamine, 4,4'-methylenebis(tetrahydro-1,2,4-thiadiazine-1,1-dioxide), were studied using highfield (1)H- and (13)C-NMR with the aid of solutions of tetrahydro-2H-1,2,4-thiadiazine-1,1-dioxide (taurultam), its two N-methyl detivatives and methylene glycol. Comparison of the (1)H-NMR spectrum of taurolidine with the one obtained from a mixture of taurultam and methylene glycol indicated that the same equilibria exists in both these solutions. It was concluded that taurolidine, taurultam and its 4-hydroxymethyl adduct and methylene glycol are the major components present. To facilitate the interpretation of the (13)C-spectra, (13)C-enriched methylene glycol was added to solutions of taurultam. The (13)C-studies confirmed the (1)H-NMR study.
authors.affiliation: Department of Pharmaceutical Sciences, University of Strathclyde, Glasgow G1 1XW, U.K.
authors.forename: H T
authors.initials: HT
authors.lastname: Hood
authors.forename: G A
authors.initials: GA
authors.lastname: Smail
authors.forename: G G
authors.initials: GG
authors.lastname: Skellern
authors.forename: D P
authors.initials: DP
authors.lastname: Jindal
authors.forename: M K
authors.initials: MK
authors.lastname: Browne
authors.forename: R W
authors.initials: RW
authors.lastname: Pfirrmann