Spinocerebellar ataxia type 12 was not found in Korean Parkinsonian patients.
BACKGROUND
Parkinsonism (PD) is occasionally seen in several types of spinocerebellar ataxia (SCA). Mutations in SCA gene have been reported in the patients of parkinsonism without ataxia.


METHODS
We examined spinocerebellar ataxia type 12 mutation in 877 PD and 199 multiple system atrophy (MSA) patients.


CONCLUSIONS
No patients showed abnormal SCA12 expansion. It suggests that PD and MSA are not associated with SCA12 and it is not necessary to screen SCA12 in PD and MSA patients.
Cho
Jin Whan
JW
Department of Neurology, College of Medicine, Seoul National University, Seoul, South Korea.
Kim
Sung Yeon
SY
Park
Sung Sup
SS
Jeon
Beom S
BS
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D004252:DNA Mutational Analysis; D005260:Female; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000209:etiology / Q000235:genetics; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000235:genetics*; D010300:Parkinson Disease / Q000209:etiology / Q000235:genetics*; D054648:Protein Phosphatase 2 / Q000235:genetics*; D020754:Spinocerebellar Ataxias / Q000150:complications* / Q000175:diagnosis / Q000235:genetics*
D009419:Nerve Tissue Proteins; C505936:PPP2R2B protein, human; D054648:Protein Phosphatase 2