Reactions of 3-aminopyrazole derivatives with cyanothioacetamide and its derivatives: Synthesis and reactions of several new pyrazole and pyrazole[3,2-b]pyrimidine derivatives.
Thiocarboxamidocinnamonitrile derivatives2 a-f reacted with 3-aminopyrazole derivatives3 a-c to give the pyrazole[3,2-b]pyrimidine derivatives6 a-p. Compounds6 a-p were used as starting material for syntheses of several heterocylic coompounds. Dehydrogenation of6 gave pyrazole[3,2-b]pyrimidines10 a-d while its reaction with diethyl oxalate gave11. Reactions of6 with formic acid gave pyrazolopyrimidines17 a-j, and pyrazolopyrimidopyrimidinoes18 a-j.
Attaby
F A
FA
Department of Chemistry, Faculty of Science, Cairo University, Giza, A.R. Egypt.
Eldin
S M
SM