title: Flow-injection fluorimetric analysis of sulfamethoxazole in pharmaceutical preparations and biological fluids.
abstract: A fluorimetric procedure for the determination of sulfamethoxazole using flow injection analysis is proposed. A two channel system is optimized for the fluorescent reaction with o-phthaldialdehyde and beta-mercaptoethanol. The detection limit is 0.007 mug/ml. No fluorescence is generated by the metabolite N-acetylated sulfamethoxazole. The method is applied to the determination of sulfamethoxazole in pharmaceuticals, urine and bovine serum samples without matrix interference problems.
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, E-30071 Murcia, Spain.
authors.forename: C L
authors.initials: CL
authors.lastname: Erroz
authors.forename: P
authors.initials: P
authors.lastname: Viñas
authors.forename: M H
authors.initials: MH
authors.lastname: Córdoba