[Preoperative hypercoagulopathy in patients undergoing orthopedic lower extremity surgery].
BACKGROUND
Plasma levels of D-dimer, soluble fibrin monomer complex (SFMC) and FDP were measured in 40 patients for orthopedic lower extremity surgery, using a recently established monoclonal antibody to clarify if these markers are good indicator of deep vein thrombosis(DVT).


METHODS
Subjects were 20 patients for total hip arthroplasty (THA) or total knee arthroplasty (TKA) (group A) and 20 patients for hip fracture surgery (group F). D-dimer, SFMC and FDP were measured at induction of anesthesia.


RESULTS
Preoperative values of D-dimer, FMC and FDP in group F were higher than those in group A, and these values in group F were higher than normal values.


CONCLUSIONS
It is concluded that plasma levels of D-dimer, SFMC and FDP in the patients with hip fracture were higher than those in the patients scheduled for TKA or THA in perioperative period. These suggest that the patients with hip fracture have high risk of DVT.
Okamura
Kenta
K
Department of Anesthesia and Critical Care, Hiroshima University Hospital, Hiroshima 734-8551.
Nakagawa
Itsuo
I
Hidaka
Syozo
S
Okada
Yasunori
Y
Kubo
Takashi
T
Kato
Takahiro
T
D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip; D019645:Arthroplasty, Replacement, Knee; D015415:Biomarkers / Q000097:blood; D042241:Early Diagnosis; D017558:Elective Surgical Procedures; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006620:Hip Fractures / Q000097:blood* / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D012306:Risk; D020246:Venous Thrombosis / Q000175:diagnosis* / Q000209:etiology*
D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; C011468:fibrinmonomer