Large-scale assignment of orthology: back to phylogenetics?
Reliable orthology prediction is central to comparative genomics. Although orthology is defined by phylogenetic criteria, most automated prediction methods are based on pairwise sequence comparisons. Recently, automated phylogeny-based orthology prediction has emerged as a feasible alternative for genome-wide studies.
Gabaldón
Toni
T
Bioinformatics and Genomics Program, Center for Genomic Regulation, Doctor Aiguader 88, Barcelona, Spain. tgabaldon@crg.es
D030541:Databases, Genetic; D016678:Genome; D023281:Genomics / Q000379:methods*; D008957:Models, Genetic; D010802:Phylogeny; D016415:Sequence Alignment / Q000379:methods