Metastasis and AKT activation.
Metastasis, responsible for 90% of cancer patient deaths, is an inefficient process because many tumor cells die. The survival of metastatic tumor cells should be considered as a critical therapeutic target. This review provides a new perspective regarding the role of AKT in tumor survival, and the rationale to target AKT in anti-metastasis therapies.
Sheng
Shijie
S
Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA. ssheng@med.wayne.edu
Qiao
Meng
M
Pardee
Arthur B
AB
D004789:Enzyme Activation; D006801:Humans; D009362:Neoplasm Metastasis / Q000473:pathology*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*
D051057:Proto-Oncogene Proteins c-akt