title: Hyperparathyroidism in a patient with autoimmune polyglandular syndrome.
abstract: Autoimmune hypercalcemia has been reported in only a few cases, and never in the context of autoimmune polyglandular syndrome. A patient with type 1, insulin-dependent diabetes mellitus, Graves' disease, and antiparietal cell antibodies presented with persistent hypercalcemia with inappropriate PTH secretion. Other causes of hypercalcemia were excluded. In this context of two associated organ-specific autoimmune diseases we searched for autoantibodies directed to parathyroid tissue and to calcium-sensing receptor. Anti-parathyroid autoantibodies were detected by indirect immunofluorescence on parathyroid adenomas, and autoantibody against a peptide of the extracellular domain of the calcium-sensing receptor were detected by immunoblotting. Autoimmune hypercalcemia may be another organ-specific feature of autoimmune polyglandular syndrome.
authors.affiliation: Hotel Dieu, APHP, Universite Rene Descartes, Paris, France.
authors.forename: Lorraine
authors.initials: L
authors.lastname: Pelletier-Morel
authors.forename: Nicole
authors.initials: N
authors.lastname: Fabien
authors.forename: Yamina
authors.initials: Y
authors.lastname: Mouhoub
authors.forename: Christian
authors.initials: C
authors.lastname: Boitard
authors.forename: Etienne
authors.initials: E
authors.lastname: Larger
mesh_terms: D001323:Autoantibodies / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications / Q000175:diagnosis; D006801:Humans; D006961:Hyperparathyroidism / Q000097:blood* / Q000150:complications / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D016884:Polyendocrinopathies, Autoimmune / Q000097:blood / Q000150:complications / Q000175:diagnosis*
chemical_list: D001323:Autoantibodies