Viral inhibitors of NKG2D ligands: friends or foes of immune surveillance?
NKG2D is a potent activating receptor on NK cells and a co-stimulatory receptor on CD8+ T cells. Through its ability to recognize a panel of ligands inducible by stress or infection, it plays an important role in the control of viral infections. The viruses have evolved robust mechanisms to counteract NKG2D-dependent immune response. The functions of these viral inhibitors are well characterized during the early days post-infection but less so during the chronic viral infection.
Jonjić
Stipan
S
Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, Brace Branchetta 20 Rijeka, Croatia. jstipan@medri.hr
Polić
Bojan
B
Krmpotić
Astrid
A
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D058851:GPI-Linked Proteins; D006566:Herpesviridae Infections / Q000276:immunology*; D006801:Humans; D007157:Immunologic Surveillance / Q000276:immunology*; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000502:physiology*; D007694:Killer Cells, Natural / Q000276:immunology; D018146:Muromegalovirus; D055655:NK Cell Lectin-Like Receptor Subfamily K / Q000037:antagonists & inhibitors / Q000502:physiology*; D011110:Polymorphism, Genetic
D058851:GPI-Linked Proteins; D036341:Intercellular Signaling Peptides and Proteins; D055655:NK Cell Lectin-Like Receptor Subfamily K; C423230:ULBP2 protein, human