title: Thrombocytopenia in preterm infants with intrauterine growth restriction.
abstract: Sick preterm infants often have thrombocytopenia at birth, and this is often associated with intrauterine growth restriction (IUGR), or birth weights less than the 10th percentile. The pathogenesis of the thrombocytopenia and its importance in IUGR are still unclear. We studied the characteristics of preterm IUGR infants with thrombocytopenia. Twenty-seven singleton Japanese preterm IUGR infants were born between January 2002 and June 2007 at Okayama University Hospital. Infants with malformation, chromosomal abnormalities, alloimmune thrombocytopenia, sepsis, and maternal aspirin ingestion were excluded. The infants were divided into group A (n=8), which had thrombocytopenia within 72 h after birth, and group B (n=19), which did not. There were significant differences in birth weight, head circumference, umbilical artery (UA)-pulsatility index (PI), middle cerebral artery-PI, UA-pH, UA-pO2, and UA-pCO2. The infants in group A were smaller, had abnormal blood flow patterns, and were hypoxic at birth. We speculate that the infants with thrombocytopenia were more severely growth-restricted by chronic hypoxia. Thrombocytopenia is an important parameter for chronic hypoxia in the uterine.
authors.affiliation: Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan. hidemaru@md.okayama-u.ac.jp
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Maruyama
authors.forename: Masako
authors.initials: M
authors.lastname: Shinozuka
authors.forename: Yo-Ichi
authors.initials: Y
authors.lastname: Kondoh
authors.forename: Yo-Ichiro
authors.initials: Y
authors.lastname: Akahori
authors.forename: Miwa
authors.initials: M
authors.lastname: Matsuda
authors.forename: Seiji
authors.initials: S
authors.lastname: Inoue
authors.forename: Yumi
authors.initials: Y
authors.lastname: Sumida
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Morishima
mesh_terms: D001724:Birth Weight / Q000502:physiology; D002245:Carbon Dioxide / Q000378:metabolism; D002536:Cerebral Arteries / Q000502:physiology; D005260:Female; D005317:Fetal Growth Retardation / Q000503:physiopathology*; D006257:Head / Q000033:anatomy & histology; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D008297:Male; D010100:Oxygen / Q000378:metabolism; D012189:Retrospective Studies; D054098:Thrombocytopenia, Neonatal Alloimmune / Q000503:physiopathology*; D014469:Umbilical Arteries / Q000502:physiology
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen