title: Synthesis of novel heterocycles through reaction of indolin-2-one derivatives with active methylene and amino reagents.
abstract: Several new spiro compounds were synthesized via one-pot ternary condensation of isatin, malononitrile and each of thiobarbituric acid, barbituric acid, 3-methyl-pyrazolin-5-one, 1-phenyl-3-methyl-pyrazolin-5-one, acetylacetone, benzoylacetone, ethyl acetoacetate, phenacyl cyanide or ethyl-cyanoacetate dimer. Structures and reaction mechanism were reported and supported via a second synthetic route.
authors.affiliation: Chemstry Department, Faculty of Science, El-Minia University, El-Minia, Egypt.
authors.forename: F F
authors.initials: FF
authors.lastname: Abdel-Latif
authors.forename: E K
authors.initials: EK
authors.lastname: Ahmed
authors.forename: R
authors.initials: R
authors.lastname: Mekheimer
authors.forename: M M
authors.initials: MM
authors.lastname: Mashaly