Advanced oxidation protein products are increased in women with polycystic ovary syndrome: relationship with traditional and nontraditional cardiovascular risk factors in patients with polycystic ovary syndrome.
OBJECTIVE
To determine whether or not plasma advanced oxidation protein products (AOPPs) are associated with known cardiovascular risk factors or carotid intima-media thickness (IMT) in patients with polycystic ovary syndrome (PCOS).


METHODS
A prospective, controlled study.


METHODS
University hospital.


METHODS
Forty-six women with PCOS and 46 age- and body mass index-matched healthy women.


METHODS
Carotid IMT was evaluated for both common carotid arteries. We measured serum levels of AOPP, homocysteine (Hcy), C-reactive protein (CRP), malonyldialdehyde (MDA), vitamin B(12), folate, lipid, and hormone profiles. The presence of insulin resistance was investigated by means of homeostasis model assessment (HOMA).


METHODS
Serum AOPP, fasting insulin, HOMA index, Hcy, MDA, CRP, and carotid IMT.


RESULTS
The women with PCOS had significantly higher serum AOPP than control women. High AOPP was defined as equaling or exceeding the mean + 2 SD of the plasma AOPP in control subjects (56.2 pg/mLl). Carotid IMT, fasting insulin, HOMA index, Hcy, MDA, and CRP were significantly higher in PCOS patients with high AOPP than in those with normal AOPP. Fasting insulin, insulin resistance, and Hcy were independent determinants of plasma AOPP.


CONCLUSIONS
Increased AOPP may contribute to the increased risk of atherosclerotic cardiovascular disease in women with PCOS.
Kaya
Cemil
C
Department of Obstetrics and Gynecology, Ufuk University, Ankara, Turkey. Electronic address: kayacemil000@yahoo.com.
Erkan
Aycan Fahri
AF
Department of Cardiology, Faculty of Medicine, Ufuk University, Ankara, Turkey.
Cengiz
S Dinçer
SD
Department of Obstetrics and Gynecology, Faculty of Medicine, Ankara University, Ankara, Turkey.
Dünder
Ilkkan
I
Department of Obstetrics and Gynecology, Faculty of Medicine, Ankara University, Ankara, Turkey.
Demirel
Özlem Erbaş
ÖE
Department of Biochemistry, Faculty of Medicine, Gazi University, Ankara, Turkey.
Bilgihan
Ayşe
A
Department of Biochemistry, Faculty of Medicine, Gazi University, Ankara, Turkey.
D000328:Adult; D001798:Blood Proteins / Q000737:chemistry / Q000378:metabolism*; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology*; D016022:Case-Control Studies; D005260:Female; D017127:Glycation End Products, Advanced / Q000097:blood* / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008055:Lipids / Q000097:blood; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism; D009765:Obesity / Q000097:blood / Q000150:complications / Q000378:metabolism; D010084:Oxidation-Reduction; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications / Q000378:metabolism*; D012307:Risk Factors; D015854:Up-Regulation; D055105:Waist Circumference; D055815:Young Adult
D001798:Blood Proteins; D017127:Glycation End Products, Advanced; D008055:Lipids; D008315:Malondialdehyde; D002097:C-Reactive Protein