title: Highly conducting transmembrane pores formed by aromatic oligoamide macrocycles.
abstract: Oligoamide macrocycles 1d and 1e, which carry membrane-compatible side chains and contain a hydrophilic, noncollapsible cavity, were found to mediate high ion flux across a lipid bilayer, as demonstrated by results from (23)Na NMR and planar bilayer conductance measurements. The measured transmembrane single channel currents are very high, rivaling those typically associated with pore-forming protein toxins. The obtained results have demonstrated the promise of developing large, highly conducting channels based on nanopores formed by oligoamide macrocycles.
authors.affiliation: Department of Chemistry, Natural Sciences Complex, University at Buffalo, The State University of New York, Buffalo, New York 14260, USA.
authors.forename: Amber Jade
authors.initials: AJ
authors.lastname: Helsel
authors.forename: Amy L
authors.initials: AL
authors.lastname: Brown
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yamato
authors.forename: Wen
authors.initials: W
authors.lastname: Feng
authors.forename: Lihua
authors.initials: L
authors.lastname: Yuan
authors.forename: Aimee J
authors.initials: AJ
authors.lastname: Clements
authors.forename: Stephanie V
authors.initials: SV
authors.lastname: Harding
authors.forename: Gabor
authors.initials: G
authors.lastname: Szabo
authors.forename: Zhifeng
authors.initials: Z
authors.lastname: Shao
authors.forename: Bing
authors.initials: B
authors.lastname: Gong
mesh_terms: D000577:Amides / Q000737:chemistry*; D002462:Cell Membrane / Q000737:chemistry*; D047028:Macrocyclic Compounds / Q000737:chemistry*; D015394:Molecular Structure; D016062:Porosity
chemical_list: D000577:Amides; D047028:Macrocyclic Compounds