Protonation constant of some sulpha-drugs in dioxan water medium.
The dissociation constants of some sulpha-drugs have been determined potentiometrically in 10-50% (v/v) dioxan-water media at 25 degrees at ionic strength O.1M (NaClO(4)). Correlation of mole fraction of dioxan and pK gives a straight line. The pK values do not vary linearly with reciprocal of the dielectric constant of the medium at high percentage of dioxan.
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Chemistry Department, D.N. College, Meerut-250002, India.