Inflammatory microenvironment promotes hemopoietic-derived angiogenic cell expansion and arterial specification.
The manuscript deals with the effects exerted by the inflammatory microenvironment on angiogenic cell expansion and arterial specification. Data reported demonstrated that the inflammatory cytokine IL-3 expands a subset of hemopoietic-derived cells, which directly contribute to neovessel formation. In addition, the identification of STAT5 as a molecular signature of the vasculogenetic process provides the rationale for a novel therapeutic strategy to manipulate vascular growth.
Dentelli
Patrizia
P
Department of Internal Medicine, University of Torino, Corso Dogliotti 14, 10126 Torino, Italy.
Brizzi
Maria Felice
MF
D000818:Animals; D001158:Arteries / Q000254:growth & development*; D002454:Cell Differentiation; D007249:Inflammation / Q000473:pathology*; D007377:Interleukin-3 / Q000502:physiology; D051379:Mice; D016513:Mice, SCID; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D050799:STAT5 Transcription Factor / Q000502:physiology; D013234:Stem Cells / Q000502:physiology*
D007377:Interleukin-3; D050799:STAT5 Transcription Factor