title: Rational design of novel antibacterial vaccines with an emphasis on tuberculosis.
abstract: Vaccines are available for some, but not all, bacterial pathogens. Accordingly, bacterial pathogens still cause major health problems. Novel insights into the basic immunological mechanisms involved in protection against bacteria will provide guidelines for the design of novel vaccines. In particular, these include broad-acting vaccines composed of protein antigens shared by all members of a given pathogen group but absent in the human host and vaccines which operate via T-cells.
authors.affiliation: Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany. kaufmann@mpiib-berlin.mpg.de
authors.forename: Stefan H E
authors.initials: SH
authors.lastname: Kaufmann
mesh_terms: D000942:Antigens, Bacterial / Q000276:immunology*; D001428:Bacterial Vaccines / Q000276:immunology; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D014376:Tuberculosis / Q000276:immunology* / Q000517:prevention & control; D032581:Tuberculosis Vaccines / Q000276:immunology
chemical_list: D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D032581:Tuberculosis Vaccines