title: Inflammatory microenvironment promotes hemopoietic-derived angiogenic cell expansion and arterial specification.
abstract: The manuscript deals with the effects exerted by the inflammatory microenvironment on angiogenic cell expansion and arterial specification. Data reported demonstrated that the inflammatory cytokine IL-3 expands a subset of hemopoietic-derived cells, which directly contribute to neovessel formation. In addition, the identification of STAT5 as a molecular signature of the vasculogenetic process provides the rationale for a novel therapeutic strategy to manipulate vascular growth.
authors.affiliation: Department of Internal Medicine, University of Torino, Corso Dogliotti 14, 10126 Torino, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Dentelli
authors.forename: Maria Felice
authors.initials: MF
authors.lastname: Brizzi
mesh_terms: D000818:Animals; D001158:Arteries / Q000254:growth & development*; D002454:Cell Differentiation; D007249:Inflammation / Q000473:pathology*; D007377:Interleukin-3 / Q000502:physiology; D051379:Mice; D016513:Mice, SCID; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D050799:STAT5 Transcription Factor / Q000502:physiology; D013234:Stem Cells / Q000502:physiology*
chemical_list: D007377:Interleukin-3; D050799:STAT5 Transcription Factor