Determination of novocaine in pharmaceutical preparations with novocaine(+)-selective membrane electrodes.
Liquid-membrane ion-selective electrodes made with the ion-association complexes of novocaine with tetraphenylborate or dipicrylamine are proposed for use in the determination of novocaine by direct potentiometry or by potentiometric titration with sodium tetraphenylborate. The titration method is preferred, and the mean relative error for 4-12 mg of novocaine hydrochloride is 0.5%.
Negoiu
D
D
Institute of Chemical and Pharmaceutical Research, 74351 Sos. Vitan 112, Bucharest, Romania.
Ionescu
M S
MS
Coşofreţ
V V
VV