Develop-WNTs in somatic cell reprogramming.
Two manuscripts published recently in Cell Stem Cell (Lluis et al., 2008 [this issue]; Marson et al., 2008) show that Wnt-beta-catenin signaling stimulates nuclear reprogramming. These two studies, using distinct reprogramming methods, offer insights into the mechanisms underlying acquisition and maintenance of pluripotency.
Merrill
Bradley J
BJ
Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA. merrillb@uic.edu
D053687:Adult Stem Cells / Q000166:cytology; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002459:Cell Fusion / Q000379:methods; D065150:Cellular Reprogramming / Q000235:genetics*; D053595:Embryonic Stem Cells / Q000166:cytology; D005347:Fibroblasts / Q000166:cytology; D018507:Gene Expression Regulation, Developmental; D053263:Gene Regulatory Networks / Q000235:genetics; D006801:Humans; D051379:Mice; D009474:Neurons / Q000166:cytology; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000502:physiology*; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics; D012190:Retroviridae / Q000235:genetics; D014161:Transduction, Genetic / Q000379:methods; D051153:Wnt Proteins / Q000378:metabolism*; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism*
D016271:Proto-Oncogene Proteins c-myc; D051153:Wnt Proteins; D051176:beta Catenin