Effect of a phyto-compound on delayed gastric emptying in functional dyspepsia: a randomized-controlled study.
OBJECTIVE
The aim of the present study was to assess the efficacy of a hydro-alcoholic solution of a phytocompound based on Gentianae, Cinchonae, Absinthii and Cinnamomi on gastric emptying in Helicobacter pylori-negative dyspeptic patients.


METHODS
The study group consisted of 24 patients with a diagnosis of long-standing dismotility-like functional dyspepsia. All patients were devoid of any major past or ongoing disease and dyspepsia-associated diseases were excluded. After a 2-week wash out period, the patients were randomized to a 2-week treatment in which they were given 20 gtt of the compound 30 min before meals. At the beginning and end of the study, a gastric emptying test was performed by a paracetamol absorption test using a standard meal. The global symptom index (GSI) was assessed daily by a validated questionnaire.


RESULTS
Treatment with the phytocompound significantly improved the gastric emptying test (P < 0.01) which was delayed in dyspeptic patients as well as GSI (P < 0.05).


CONCLUSIONS
This phytocompound might be an effective therapeutic option in the treatment of dismotility-like dyspepsia.
Metugriachuk
Yussef
Y
TMC Hospital, Shizuoka, Japan.
Marotta
Francesco
F
Kuroi
Ojime
O
Tsuchiya
Junji
J
Goh
Khean-Lee
KL
Minelli
Emilio
E
Kawakita
Satoru
S
D000082:Acetaminophen / Q000493:pharmacokinetics; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000493:pharmacokinetics; D004415:Dyspepsia / Q000188:drug therapy* / Q000503:physiopathology*; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal
D018712:Analgesics, Non-Narcotic; D010936:Plant Extracts; D000082:Acetaminophen