title: [Combined treatment with dacarbazine, nimustine, cisplatin, and tamoxifen plus interferon-beta in a patient with advanced anorectal malignant melanoma].
abstract: A 73-year-old man, who was diagnosed as having advanced anorectal malignant melanoma (Stage IV), was treated with combination chemotherapy using dacarbazine, nimustine, cisplatin, and tamoxifen plus interferon-beta. After the first course of chemotherapy, rectal tumor was decreased in size with less anal pain and liver tumor was disappeared. Twenty-four months after the first treatment, the patient is survived. DAC-Tam IFN-beta therapy may improve the management of patients who have advanced MM of the anorectum.
authors.affiliation: Third Department of Internal Medicine (Gastroenterology and Metabolism), University of Occupational and Environmental Health, Japan, School of Medicine.
authors.forename: Noriko
authors.initials: N
authors.lastname: Kawano
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Tashiro
authors.forename: Masashi
authors.initials: M
authors.lastname: Taguchi
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kihara
authors.forename: Ichiro
authors.initials: I
authors.lastname: Yoshikawa
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Syukuwa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yamasaki
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Kume
authors.forename: Makoto
authors.initials: M
authors.lastname: Otsuki
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001005:Anus Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage; D003606:Dacarbazine / Q000008:administration & dosage; D006801:Humans; D016899:Interferon-beta / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology; D009367:Neoplasm Staging; D015376:Nimustine / Q000008:administration & dosage; D012004:Rectal Neoplasms / Q000188:drug therapy*; D013629:Tamoxifen / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D013629:Tamoxifen; D015376:Nimustine; D016899:Interferon-beta; D003606:Dacarbazine; D002945:Cisplatin