title: A study of robustness with multivariate calibration. Application to the polarographic determination of benzaldehyde.
abstract: A procedure to evaluate the robustness of an analytical method when there are changes in some experimental variables, when using multivariate calibration, is proposed. The procedure consists of analysing the root mean square error of prediction (RMSEP) as a response to a Plackett-Burman experimental design, through which the influence of several experimental factors on the prediction capability of the multivariate partial least squares (PLS) models built is studied. Two different ways of analysing the experimental design response are considered: establishing the residual variance with replicates and using Lenth's method. The proposed methodology has been applied to estimate the robustness of the polarographic determination of benzaldehyde when PLS calibration is used.
authors.affiliation: Department of Chemistry, Faculty of Sciences, University of Burgos, Plaza Misael Bañuelos s/n, 09001 Burgos, Spain.
authors.forename: M B
authors.initials: MB
authors.lastname: Sanz
authors.forename: L A
authors.initials: LA
authors.lastname: Sarabia
authors.forename: A
authors.initials: A
authors.lastname: Herrero
authors.forename: M C
authors.initials: MC
authors.lastname: Ortiz