Liquid chromatography studies of solute-chain interaction under reordering/resolvation conditions-I Correlations between solute structure and changes in retention for hydroxylated aliphatic and aromatic compounds.
The current investigation is an extension of previous liquid chromatography studies involving conformational changes of n-alkyl-bonded phases under totally aqueous mobile phase conditions. Relative changes in retention, Deltak'(r), before and after reordering/resolvation of an octyl phase have been studied with various linear, branched, cyclic and aromatic compounds. The magnitude of Deltak'(r) can be correlated to structural features in the solute, such as size, shape, rigidity and substitution. The largest values of Deltak'(r) were obtained for rigid solutes with multiple hydroxy groups.
Yang
S S
SS
Department of Chemistry, Kent State University, Kent, OH 44242, U.S.A.
Gilpin
R K
RK