Clean synthesis and antibacterial activities of spiro[pyrimido[4,5-b]quinoline-5,5'-pyrrolo[2,3-d]pyrimidine]-pentaones.
A simple, clean and efficient method for the synthesis of spiro[pyrimido[4,5-b]quinoline-5,5'-pyrrolo[2,3-d]pyrimidine]-pentaone derivatives by condensation reaction of 6-amino-uracils and isatins in aqueous media is reported. These products were evaluated in vitro for their antibacterial activities.
Ghahremanzadeh
Ramin
R
Department of Chemistry, Shahid Beheshti University, Tehran, Iran.
Azimi
Seyyedeh Cobra
SC
Gholami
Nader
N
Bazgir
Ayoob
A
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D007510:Isatin / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D012995:Solubility; D012997:Solvents; D013055:Spectrophotometry, Infrared; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D014498:Uracil / Q000737:chemistry
D000900:Anti-Bacterial Agents; D006576:Heterocyclic Compounds, 4 or More Rings; D007202:Indicators and Reagents; D011743:Pyrimidines; D012997:Solvents; D013141:Spiro Compounds; D014498:Uracil; D007510:Isatin