[The antioxidative effect of Sanwei Tanxiang powder on rats' hearts against myocardial ischemia and reperfusion injury].
OBJECTIVE
To study the effect of Sanwei Tanxiang powder on myocardial pathologic change, myocardium lipid peroxidation and antioxidation on anesthetized rats' hearts against myocardial ischemia and reperfusion injury.


METHODS
A model of regional myocardial ischemia-reperfusion injury (IR) was established by 30 min ligation of the left anterior descending coronary artery followed by 40 min reperfusion in hearts of anesthetized rats'. The experimental animals were randomly divided into the sham operation, IR model group, positive control group and two dose Sanwei Tanxiang powder groups. The changes of ECG, LDH, CK, SOD, GSH-Px and MDA in the heart were measured and ultrastructural pathological changes were observed.


RESULTS
In Sanwei Tanxiang groups the displacement of ST segment reduced (P < 0.05), the activity of LDH, CK decreased (P < 0.05), the activities of SOD, GSH-Px significantly increased and the contents of MDA reduced (P < 0.05). Moreover, the development of ultrastructral pathological changes obviously improved compared with the IR model group.


CONCLUSIONS
The protective effects of Sanwei Tanxiang powder on anesthetized rats' hearts against myocardial ischemia and reperfusion injury may be related to protecting the antioxidants and inhibiting the lipid peroxidation in the myocardium.
Kou
Yi-Ying
YY
Medical College Qinghai University, Xining 810001, China. kouyiying2000@yahoo.com.cn
Zha
Xi-Duojie
XD
Li
Yong-Fang
YF
Ge
Ri-Li
RL
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D003402:Creatine Kinase / Q000097:blood; D004195:Disease Models, Animal; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004562:Electrocardiography; D005260:Female; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D017202:Myocardial Ischemia / Q000150:complications; D015428:Myocardial Reperfusion Injury / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D010946:Plants, Medicinal / Q000737:chemistry*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D032123:Santalum / Q000737:chemistry; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D008315:Malondialdehyde; D007770:L-Lactate Dehydrogenase; D013482:Superoxide Dismutase; D003402:Creatine Kinase