title: Expected poor ovarian response in predicting cumulative pregnancy rates: a powerful tool.
abstract: Poor ovarian response in IVF cycles is associated with poor pregnancy rates. Expected poor responders may represent the worst prognostic group. Data were used from 222 patients starting the first of three IVF treatment cycles. The predictability of ongoing pregnancy after three cycles was analysed using survival analysis and hazard rate ratios. If first cycle poor responders were also predicted to have a poor response, they were classified as expected poor responders. The predicted pregnancy rate in cycles 2 and 3 for women with an observed poor response in the first cycle was approximately 24% for women aged 30 years and approximately 14% for women aged 40 years. For women with an expected poor response these rates were 12% and 6%, respectively. In contrast, women aged 40 years with an unexpected poor response still had a predicted cumulative pregnancy rate of 24%. Age as a sole predictor of cumulative pregnancy does not help to identify poor prognosis cases. Cumulative pregnancy rates in subsequent cycles for patients with an observed poor response in the first cycle may be a reason to refrain from further treatment. However, if such poor response has been expected, further treatment may be avoided because of an unfavourable prognosis for pregnancy.
authors.affiliation: Department of Reproductive Medicine, Division of Obstetrics, Neonatology and Gynecology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. d.hendriks@umcutrecht.nl
authors.forename: Dave J
authors.initials: DJ
authors.lastname: Hendriks
authors.forename: Egbert R
authors.initials: ER
authors.lastname: te Velde
authors.forename: Caspar W N
authors.initials: CW
authors.lastname: Looman
authors.forename: László F J M M
authors.initials: LF
authors.lastname: Bancsi
authors.forename: Frank J M
authors.initials: FJ
authors.lastname: Broekmans
mesh_terms: D000328:Adult; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007246:Infertility / Q000503:physiopathology / Q000628:therapy; D008423:Maternal Age; D010053:Ovary / Q000187:drug effects / Q000503:physiopathology; D010062:Ovulation Induction; D011247:Pregnancy; D011256:Pregnancy Outcome; D011336:Probability; D011379:Prognosis; D011446:Prospective Studies; D027724:Reproductive Techniques, Assisted; D020554:Sperm Injections, Intracytoplasmic