Boron neutron capture therapy for newly diagnosed glioblastoma.
We evaluate the clinical results of a form of tumor selective particle radiation known as boron neutron capture therapy (BNCT) for newly-diagnosed glioblastoma (NDGB) patients, especially in combination with X-ray treatment (XRT). Between 2002 and 2006, we treated 21 patients of NDGB with BNCT utilizing sodium borocaptate and boronophenylalanine simultaneously. The first 10 were treated with only BNCT (protocol 1), and the last 11 were treated with BNCT followed by XRT of 20 to 30 Gy (protocol 2) to reduce the possibility of local tumor recurrence. No chemotherapy was applied until tumor progression was observed. The patients treated with BNCT (protocol 1 plus 2) showed a significant survival prolongation compared with the institutional historical controls. BNCT also showed favorable results in correspondence with the RTOG- and EORTC-RPA subclasses. The median survival time (MST) was 15.6 months for protocols 1 and 2 together. For protocol 2, the MST was 23.5 months. The main causes of death were cerebrospinal fluid dissemination as well as local recurrence. Our modified BNCT protocol showed favorable results of patients with NDGB not only for those with good prognoses but also for those with poor prognoses.
Kawabata
Shinji
S
Department of Neurosurgery, Osaka Medical College, Takatsuki, Japan.
Miyatake
Shin-Ichi
S
Kuroiwa
Toshihiko
T
Yokoyama
Kunio
K
Doi
Atsushi
A
Iida
Kyoko
K
Miyata
Shiro
S
Nonoguchi
Naosuke
N
Michiue
Hiroyuki
H
Takahashi
Masatsugu
M
Inomata
Taisuke
T
Imahori
Yoshio
Y
Kirihata
Mitsunori
M
Sakurai
Yoshinori
Y
Maruhashi
Akira
A
Kumada
Hiroaki
H
Ono
Koji
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D001932:Brain Neoplasms / Q000175:diagnosis / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D005260:Female; D005909:Glioblastoma / Q000175:diagnosis / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult