Rapid encephalopathy associated with anti-D immune globulin treatment for idiopathic thrombocytopenic purpura.
Rho (D) immune globulin intravenous (IV RhIG, WinRho SDF) has been shown to be a safe treatment for idiopathic thrombocytopenic purpura. Common side effects of IV RhIG include mild hemolysis, febrile reaction and headache. Significant hemolysis with renal impairment is infrequently noted. A single case of irreversible encephalopathy following IV RhIG has been reported. We report a second case of encephalopathy following an infusion of IV RhIG for treatment of idiopathic thrombocytopenic purpura.
Golla
Sunitha
S
Department of Medicine, MetroWest Medical Center, Framingham, Mass., USA.
Horkan
Clare
C
Dogaru
Grigore
G
Teske
Thomas E
TE
Christopher
Kenneth
K
D000369:Aged, 80 and over; D002543:Cerebral Hemorrhage; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D020258:Neurotoxicity Syndromes / Q000175:diagnosis / Q000209:etiology*; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications / Q000188:drug therapy*; D018029:Rho(D) Immune Globulin / Q000009:adverse effects*
D018029:Rho(D) Immune Globulin