Common 5p15.33 and 6p21.33 variants influence lung cancer risk.
We conducted a genome-wide association (GWA) study of lung cancer comparing 511,919 SNP genotypes in 1,952 cases and 1,438 controls. The most significant association was attained at 15q25.1 (rs8042374; P = 7.75 x 10(-12)), confirming recent observations. Pooling data with two other GWA studies (5,095 cases, 5,200 controls) and with replication in an additional 2,484 cases and 3,036 controls, we identified two newly associated risk loci mapping to 6p21.33 (rs3117582, BAT3-MSH5; P(combined) = 4.97 x 10(-10)) and 5p15.33 (rs401681, CLPTM1L; P(combined) = 7.90 x 10(-9)).
Wang
Yufei
Y
Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK.
Broderick
Peter
P
Webb
Emily
E
Wu
Xifeng
X
Vijayakrishnan
Jayaram
J
Matakidou
Athena
A
Qureshi
Mobshra
M
Dong
Qiong
Q
Gu
Xiangjun
X
Chen
Wei Vivien
WV
Spitz
Margaret R
MR
Eisen
Timothy
T
Amos
Christopher I
CI
Houlston
Richard S
RS
D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics*; D016022:Case-Control Studies; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide