[Topical terbinafine. Reduction of duration of therapy for tinea pedis].
Superficial fungal infections are common and worldwide in distribution. Latest estimates suggest one- third of the population in Europe has a fungal infection of their feet, with dermatophyte infections of the skin of the feet (tinea pedis) most common. Tinea pedis interdigitalis is by far most common and can be effectively treated topically. Common agents include azoles, hydroxypyridones and allylamines, with morpholines used less frequently. While most antifungals have mainly fungistatic effects on dermatophytes, the causative agents of tinea pedis, terbinafine--an allylamine--is fungicidal. Due to this feature shorter treatment periods are possible using topical terbinafine. For effective treatment of uncomplicated tinea pedis interdigitalis, azole cream preparations are often used twice daily for four weeks whereas 1% terbinafine cream can be applied once a day for one week. Since 2006, 1% terbinafine is also available as a film-forming solution (FFS), which makes single-dose treatment possible. FFS may prove superior in daily practice with increased compliance and thus reduced recurrences.
Schmid-Wendtner
M-H
MH
Klinik und Poliklinik für Dermatologie und Allergologie, Rheinische Friedrich-Wilhelms-Universität Bonn, Sigmund-Freud-Strasse 25, 53105, Bonn. Monika-Hildegard.Schmid-Wendtner@ukb.uni-bonn.de
Korting
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H
D000287:Administration, Topical; D000935:Antifungal Agents / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009281:Naphthalenes / Q000008:administration & dosage*; D000077291:Terbinafine; D013997:Time Factors; D014008:Tinea Pedis / Q000188:drug therapy*; D016896:Treatment Outcome
D000935:Antifungal Agents; D009281:Naphthalenes; D000077291:Terbinafine