Effect of PVP K30 and/or L-arginine on stability constant of etoricoxib-HPbetaCD inclusion complex: preparation and characterization of etoricoxib-HPbetaCD binary system.
The effect of polyvinyl pyrrolidone (PVP) K30 and/or L-arginine on etoricoxib-HPbetaCD complex was investigated. The phase solubility profiles were classified as A(L)-type, both in absence or presence of auxiliary substances used. The apparent stability constant (K(c)) of binary complex obtained at room temperature, 371.80 +/- 2.61 M(-1), was decreased with the addition of PVP and arginine indicating no benefit of addition of auxiliary substances to promote higher complexation efficiency. Therefore, solid etoricoxib-HPbetaCD binary systems were prepared and characterized by proton nuclear magnetic resonance spectroscopy (1HNMR), X-ray powder diffractometry, Fourier transformation-infrared spectroscopy, and dissolution studies. Among all binary systems, a lyophilized product showed superior performance in enhancing dissolution of etoricoxib.
Shah
Manali
M
Department of Pharmaceutical Chemistry, Government College of Pharmacy, Karad, Maharashtra, India.
Karekar
Poonam
P
Sancheti
Pankajkumar
P
Vyas
Vikrant
V
Pore
Yogesh
Y
D000073738:2-Hydroxypropyl-beta-cyclodextrin; D001120:Arginine / Q000737:chemistry; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry*; D004355:Drug Stability; D000077613:Etoricoxib; D005079:Excipients / Q000737:chemistry*; D005612:Freeze Drying; D009682:Magnetic Resonance Spectroscopy; D011205:Povidone / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013450:Sulfones / Q000737:chemistry*; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins / Q000737:chemistry*
D016861:Cyclooxygenase Inhibitors; D005079:Excipients; D011725:Pyridines; D013450:Sulfones; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D001120:Arginine; D011205:Povidone; D000077613:Etoricoxib