title: Dexketoprofen trometamol: clinical evidence supporting its role as a painkiller.
abstract: Since the last review about the safety and efficacy of dexketoprofen trometamol, new clinical evidence supporting its advantages has been published. Concerning the oral formulation, studies about its pharmacokinetics in special populations and efficacy studies in various pain conditions are now available. Conversely, with the approval of a parenteral formulation, dexketoprofen trometamol nowadays has a wider scope of possible indications. Studies with the parenteral formulation have proven an analgesic efficacy similar to its comparators, an opioid-sparing effect, lower incidence of nausea and vomiting, better quality of sleep and lesser degree of sedation. Altogether, the overall benefit-risk ratio of both formulations in the approved indications remains positive. Its proven effectiveness and repeatedly demonstrated rapid onset of action combined with its safety profile make dexketoprofen trometamol an interesting alternative with greater versatility, and support its administration as a first-line painkiller.
authors.affiliation: Centre d'Investigació del Medicament, Institut de Recerca, Hospital de la Santa Creu i Sant Pau, Department of Pharmacology and Therapeutics, Autonomous University of Barcelona, Barcelona, Spain. mbarbanoj@santpau.cat
authors.forename: Manuel J Barbanoj
authors.initials: MJ
authors.lastname: Rodríguez
authors.forename: Rosa M Antonijoan
authors.initials: RM
authors.lastname: Arbós
authors.forename: Salvador Rico
authors.initials: SR
authors.lastname: Amaro
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D006801:Humans; D007660:Ketoprofen / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D010146:Pain / Q000188:drug therapy*; D014325:Tromethamine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D014325:Tromethamine; D007660:Ketoprofen; C118296:dexketoprofen trometamol