Engineering design and molecular dynamics of mucoadhesive drug delivery systems as targeting agents.
The goal of this critical review is to provide a critical analysis of the chain dynamics responsible for the action of micro- and nanoparticles of mucoadhesive biomaterials. The objective of using bioadhesive controlled drug delivery devices is to prolong their residence at a specific site of delivery, thus enhancing the drug absorption process. These mucoadhesive devices can protect the drug during the absorption process in addition to protecting it on its route to the delivery site. The major emphasis of recent research on mucoadhesive biomaterials has been on the use of adhesion promoters, which would enhance the adhesion between synthetic polymers and mucus. The use of adhesion promoters such as linear or tethered polymer chains is a natural result of the diffusional characteristics of adhesion. Mucoadhesion depends largely on the structure of the synthetic polymer gels used in controlled release applications.
Serra
Laura
L
Biomaterials, Drug Delivery, Bionanotechnology and Molecular Recognition Laboratories, University of Texas at Austin, Austin, TX 78712, USA.
Doménech
Josep
J
Peppas
Nicholas A
NA
D000268:Adhesiveness; D000818:Animals; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D020100:Hydrogels / Q000008:administration & dosage; D008863:Microspheres; D009092:Mucous Membrane / Q000378:metabolism; D053758:Nanoparticles / Q000008:administration & dosage; D011108:Polymers / Q000737:chemistry*
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D020100:Hydrogels; D011108:Polymers