The facile and efficient synthesis of 8-chloroadenosine 3',5'-cyclic monophosphate by phosphorylative cyclization of 8-chloroadenosine and its characterization by(1)H and (13)C NMR spectroscopy.
Purine nucleosides were chlorinated by the reaction of acyl chloride in DMF with MCPBA under mild conditions with moderate yields. And, satisfactory method for the synthesis of ribonucleoside-3',5'-cyclic phosphates and its characterization by(1)H and(13)C nmr spectroscopy is described.
Woo
N T
NT
II-Yang Central Research Institute, Hagal 182-4, Kiheung, 449-900, Yongin, Kyungki, Korea.
Jin
S Y
SY
Cho
D J
DJ
Kim
N S
NS
Bae
E H
EH
Jung
J H
JH
Ham
W H
WH
Jung
Y H
YH