Ischemic preconditioning of the liver: a few perspectives from the bench to bedside translation.
Utilization of ischemic preconditioning to ameliorate ischemia/reperfusion injury has been extensively studied in various organs and species for the past two decades. While hepatic ischemic preconditioning in animals has been largely beneficial, translational efforts in the two clinical contexts--liver resection and decreased donor liver transplantation--have yielded mixed results. This review is intended to critically examine the translational data and identify some potential reasons for the disparate clinical results, and highlight some issues for further studies.
Desai
Kunj K
KK
Department of Surgery, University of Medicine and Dentistry-New Jersey Medical School, Newark, NJ, USA.
Dikdan
George S
GS
Shareef
Asif
A
Koneru
Baburao
B
D000368:Aged; D000818:Animals; D001926:Brain Death; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D006801:Humans; D019194:Ischemic Preconditioning; D008099:Liver / Q000601:surgery; D008111:Liver Function Tests; D016031:Liver Transplantation / Q000379:methods*; D008875:Middle Aged; D015427:Reperfusion Injury; D013997:Time Factors