Plastic membrane electrodes responsive to beta-blocker drugs.
The construction and performance characteristics of ion-selective PVC membrane electrodes for metoprolol, propranolol and timolol are described. The electrodes, based on ion-pair complexes with dinonylnaphthalenesulphonate or with tetra(2-chlorophenyl)borate show near-Nernstian responses down to 10(-5)M drug concentration. Their selectivity relative to various inorganic and organic cations is reported. Direct potentiometry is used to determine beta-blocker drugs both in aqueous solutions and pharmaceutical preparations, with good results.
Zhang
Z R
ZR
Department of Chemistry, Shanghai Teacher's University, 10 Guilin Road, Shanghai, People's Republic of China.
Yi Mao
D
D
Li
Y X
YX
Coşofreţ
V V
VV