L-ornithine-L-aspartate infusion efficacy in hepatic encephalopathy.
OBJECTIVE
To determine the efficacy of L-ornithine-L-aspartate in treatment of hepatic encephalopathy.


METHODS
Randomized, placebo-controlled trial.


METHODS
Department of Gastroenterology and Hepatology, Sheikh Zayed Hospital, Lahore, from February to August 2005.


METHODS
Cirrhotic patients with hyperammonemia and overt hepatic encephalopathy were enrolled. Eighty patients were randomized to two treatment groups, L-ornithine-L-aspartate (20 g/d) or placebo, both dissolved in 250 mL of 5% dextrose water and infused intravenously for four hours a day for five consecutive days with 0.5 g/kg dietary protein intake at the end of daily treatment period. Outcome variables were postprandial blood ammonia and mental state grade. Adverse reactions and mortality were also determined.


RESULTS
Both treatment groups were comparable regarding age, gender, etiology of cirrhosis, Child-Pugh class, mental state grade and blood ammonia at baseline. Although, improvement occurred in both groups, there was a greater improvement in L-ornithine-L-aspartate group with regard to both variables. Four patients in the placebo group and 2 in L-ornithine-L-aspartate group died.


CONCLUSIONS
L-ornithine-L-aspartate infusions were found to be effective in cirrhotic patients with hepatic encephalopathy.
Ahmad
Irfan
I
Department of Medicine, Sheikh Zayed Medical College/Hospital, Rahim Yar Khan. uhirfan@yahoo.com
Khan
Anwaar A
AA
Alam
Altaf
A
Dilshad
Akif
A
Butt
Arshad Kamal
AK
Shafqat
Farzana
F
Malik
Kashif
K
Sarwar
Shahid
S
D000328:Adult; D000368:Aged; D000641:Ammonia / Q000097:blood*; D003071:Cognition; D004151:Dipeptides / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006305:Health Status Indicators; D006501:Hepatic Encephalopathy / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D022124:Hyperammonemia / Q000188:drug therapy*; D007262:Infusions, Intravenous; D008103:Liver Cirrhosis / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period / Q000187:drug effects
D004151:Dipeptides; D000641:Ammonia; C002939:ornithylaspartate