title: Crocidolite and mesothelioma.
abstract: This study reports changes in the frequency of detection of various asbestos fiber types between 1982 and 2005. Crocidolite is increasingly detected in U.S. mesothelioma patients. The percentage of crocidolite fibers detected in lung tissue has risen from 4 to 10%, and the percentage of cases in which crocidolite was detected increased from 19 to 37%. Meanwhile, the frequency of detection of amosite and chrysotile has decreased. The authors performed a detailed analysis of cases in which crocidolite was identified in the absence of amosite. Most of such cases were identified in recent years, a finding of concern since crocidolite is considered the most potent fiber type with respect to the pathogenesis of mesothelioma.
authors.affiliation: Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA. frank.schneider@duke.edu
authors.forename: Frank
authors.initials: F
authors.lastname: Schneider
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Sporn
authors.forename: Victor L
authors.initials: VL
authors.lastname: Roggli
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017639:Asbestos, Amosite / Q000009:adverse effects / Q000032:analysis*; D017638:Asbestos, Crocidolite / Q000009:adverse effects / Q000032:analysis*; D005260:Female; D006801:Humans; D008168:Lung / Q000737:chemistry*; D008297:Male; D008654:Mesothelioma / Q000737:chemistry* / Q000209:etiology; D008875:Middle Aged; D019016:Mineral Fibers; D010534:Peritoneal Neoplasms / Q000737:chemistry* / Q000209:etiology; D010997:Pleural Neoplasms / Q000737:chemistry* / Q000209:etiology; D012042:Registries
chemical_list: D019016:Mineral Fibers; D017638:Asbestos, Crocidolite; D017639:Asbestos, Amosite