title: Effects of liquid phase on basic properties of alpha-tricalcium phosphate-based apatite cement.
abstract: Effects of liquid phase on the basic properties of alpha-tricalcuim phosphate (alpha-TCP)-based cement, BIOPEX, were investigated by employing three liquid phases: distilled water, neutral sodium hydrogen phosphate solution, and succinic acid disodium salt solution containing sodium salt of chondroitin sulfate. When mixed with neutral sodium hydrogen phosphate or succinic acid disodium salt solution, the initial setting times of the cement were 19.4 +/- 0.55 and 11.8 +/- 0.45 minutes respectively. These setting times were much shorter than that of distilled water, 88.4 +/- 0.55 minutes. Formation of needle-like crystals typical of apatite was much faster when neutral sodium hydrogen phosphate solution was used, as compared to distilled water or succinic acid disodium salt solution. Moreover, at 24 hours after mixing, the largest amount of apatite was formed when neutral sodium hydrogen phosphate solution was used, whereas use of succinic acid resulted in the least. On the final mechanical strength of the cement, that yielded with neutral sodium hydrogen phosphate solution was the highest. In contrast, lower mechanical strength was observed--especially at the initial stage--when succinic acid sodium salt was used. It was thus concluded that alpha-TCP-based cement allowed accelerated transformation to apatite, and that higher mechanical strength since the initial stage was achieved when neutral sodium hydrogen phosphate solution was used as the liquid phase.
authors.affiliation: Department of Biomaterials, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Oda
authors.forename: Akari
authors.initials: A
authors.lastname: Takeuchi
authors.forename: Xin
authors.initials: X
authors.lastname: Lin
authors.forename: Shigeki
authors.initials: S
authors.lastname: Matsuya
authors.forename: Kunio
authors.initials: K
authors.lastname: Ishikawa
mesh_terms: D001031:Apatites / Q000138:chemical synthesis / Q000737:chemistry*; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry*; D001843:Bone Cements / Q000138:chemical synthesis / Q000737:chemistry*; D002130:Calcium Phosphates / Q000138:chemical synthesis / Q000737:chemistry*; D055598:Chemical Phenomena; D002809:Chondroitin Sulfates / Q000138:chemical synthesis / Q000737:chemistry; D003460:Crystallization; D006801:Humans; D006882:Hydroxyapatites / Q000138:chemical synthesis / Q000737:chemistry; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D044367:Phase Transition; D010756:Phosphoric Acids / Q000737:chemistry; D012996:Solutions / Q000737:chemistry; D013314:Stress, Mechanical; D013386:Succinates / Q000138:chemical synthesis / Q000737:chemistry; D019802:Succinic Acid / Q000737:chemistry; D013997:Time Factors; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D001031:Apatites; D001672:Biocompatible Materials; C481019:Biopex; D001843:Bone Cements; D002130:Calcium Phosphates; D006882:Hydroxyapatites; D010756:Phosphoric Acids; D012996:Solutions; D013386:Succinates; C485828:alpha-tricalcium phosphate; D014867:Water; D002809:Chondroitin Sulfates; D019802:Succinic Acid; C030242:phosphoric acid