Cardiovascular effects of acute hyperglycaemia: pathophysiological underpinnings.
High admission blood glucose levels after acute myocardial infarction are common and are associated with an increased risk of death in subjects with and without diabetes. In this review, the possible toxic effects of acute hyperglycaemia are discussed as a possible explanation for the worse prognosis in subjects with myocardial infarction and concomitant hyperglycaemia. In particular, evidence supporting the hypothesis that acute hyperglycaemia may favour the appearance of cardiovascular disease through the generation of oxidative stress is presented.
Ceriello
Antonio
A
Warwick Medical School, Clinical Science Research Institute, University Hospital -Coventry, CV2 2DX, UK. antonio.ceriello@warwick.ac.uk
D000208:Acute Disease; D001786:Blood Glucose / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000378:metabolism / Q000401:mortality / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D006943:Hyperglycemia / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism / Q000401:mortality / Q000503:physiopathology; D015228:Hypertriglyceridemia / Q000150:complications; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D009203:Myocardial Infarction / Q000150:complications* / Q000378:metabolism / Q000401:mortality / Q000503:physiopathology; D018384:Oxidative Stress; D011379:Prognosis; D012307:Risk Factors
D001786:Blood Glucose; D007004:Hypoglycemic Agents