Imbalanced distribution of GM immunoglobulin allotypes according to the clinical presentation of Plasmodium falciparum malaria in Beninese children.
Selection pressure exerted by pathogens contributes to the persistence of polymorphisms in GM and KM allotypes, which are antigenic determinants of immunoglobulins. This study investigated the impact of GM and KM allotypes on the clinical response to Plasmodium falciparum infection among Beninese children, including 65 with severe malaria, 37 with uncomplicated malaria, and 53 with asymptomatic carriage. An inverse relationship was found between the GM 5,6,13,14; 1,17 phenotype and uncomplicated malaria. Genetic markers implicated in the composition and activity of immunoglobulins may be associated with the genetic control of both malaria infection and morbidity.
Migot-Nabias
Florence
F
Institut de Recherche pour le Développement, Unité de Recherche 010, Faculté des Sciences de la Santé et Institut des Sciences Biomédicales Appliquées, Cotonou, Bénin. migot@ird.fr
Noukpo
Julien M
JM
Guitard
Evelyne
E
Doritchamou
Justin
J
Garcia
André
A
Dugoujon
Jean-Michel
JM
D000293:Adolescent; D000818:Animals; D001541:Benin / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D020022:Genetic Predisposition to Disease; D006801:Humans; D007129:Immunoglobulin Gm Allotypes / Q000235:genetics*; D007223:Infant; D016778:Malaria, Falciparum / Q000453:epidemiology* / Q000235:genetics*; D010963:Plasmodium falciparum
D007129:Immunoglobulin Gm Allotypes