title: Spatial consistency in 3D tract-based clustering statistics.
abstract: We propose a novel technique for tract-based comparison of DTI-indices between groups, based on a representation that is estimated while matching fiber tracts. The method involves a non-rigid registration based on a joint clustering and matching approach, after which a 3D-atlas of cluster center points is used as a frame of reference for statistics. Patient and control FA-distributions are compared per cluster. Spatial consistency is taken to reflect a significant difference between groups. Accordingly, a non-parametric classification is performed to assess the continuity of pathology over larger tract regions. In a study to infant survivors treated for medulloblastoma with intravenous methotrexate and cranial radiotherapy, significant decreases in FA in major parts of the corpus callosum were found.
authors.affiliation: Department of Radiology, Academic Medical Center, University of Amsterdam, NL. m.w.a.caan@tudelft.nl
authors.forename: Matthan W A
authors.initials: MW
authors.lastname: Caan
authors.forename: Lucas J
authors.initials: LJ
authors.lastname: van Vliet
authors.forename: Charles B L M
authors.initials: CB
authors.lastname: Majoie
authors.forename: Eline J
authors.initials: EJ
authors.lastname: Aukema
authors.forename: C A
authors.initials: CA
authors.lastname: Grimbergen
authors.forename: Frans M
authors.initials: FM
authors.lastname: Vos
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D002528:Cerebellar Neoplasms / Q000175:diagnosis*; D002648:Child; D016000:Cluster Analysis; D003198:Computer Simulation; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008527:Medulloblastoma / Q000175:diagnosis*; D008954:Models, Biological; D015233:Models, Statistical; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity