title: Pleomorphic malignant fibrous histiocytoma: response of bone, lung, and brain metastases to chemotherapy.
abstract: We present a case of pleomorphic malignant fibrous histiocytoma arising from the left forearm in a 45-year-old man who had undergone resection and radiotherapy for a tumor 3 years previously. At his first visit, he had multiple lung and bone metastases. Although these metastases responded well to systemic chemotherapy, brain metastases newly appeared and caused the death of the patient. These findings demonstrate that individual sarcomatous metastatic organs exhibit different sensitivities to chemotherapy. The mechanism of this phenomenon is discussed with a review of previous reports. It is suggested that the blood-brain barrier may play an important role in sensitivity to chemotherapy.
authors.affiliation: Department of Orthopedic Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan. hoshi@med.osaka-cu.ac.jp
authors.forename: Manabu
authors.initials: M
authors.lastname: Hoshi
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Takami
authors.forename: Makoto
authors.initials: M
authors.lastname: Ieguchi
mesh_terms: D000077:Acetabulum; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000628:therapy; D001842:Bone and Bones / Q000187:drug effects; D001921:Brain / Q000187:drug effects; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000556:secondary / Q000628:therapy; D004317:Doxorubicin / Q000008:administration & dosage; D005542:Forearm; D051677:Histiocytoma, Malignant Fibrous / Q000188:drug therapy* / Q000556:secondary / Q000628:therapy; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008168:Lung / Q000187:drug effects; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local
chemical_list: D004317:Doxorubicin; D007069:Ifosfamide