title: IMGT, the international ImMunoGeneTics information system.
abstract: IMGT, the international ImMunoGeneTics information system (http://www.imgt.org), was created in 1989 by Marie-Paule Lefranc, Laboratoire d'ImmunoGénétique Moléculaire LIGM (Université Montpellier 2 and CNRS) at Montpellier, France, in order to standardize and manage the complexity of immunogenetics data. The building of a unique ontology, IMGT-ONTOLOGY, has made IMGT the global reference in immunogenetics and immunoinformatics. IMGT is a high-quality integrated knowledge resource specialized in the immunoglobulins or antibodies, T cell receptors, major histocompatibility complex, of human and other vertebrate species, proteins of the IgSF and MhcSF, and related proteins of the immune systems of any species. IMGT provides a common access to standardized data from genome, proteome, genetics and 3D structures. IMGT consists of five databases (IMGT/LIGM-DB, IMGT/GENE-DB, IMGT/3Dstructure-DB, etc.), fifteen interactive online tools for sequence, genome and 3D structure analysis, and more than 10,000 HTML pages of synthesis and knowledge. IMGT is used in medical research (autoimmune diseases, infectious diseases, AIDS, leukemias, lymphomas and myelomas), veterinary research, biotechnology related to antibody engineering (phage displays, combinatorial libraries, chimeric, humanized and human antibodies), diagnostics (clonalities, detection and follow-up of residual diseases) and therapeutical approaches (graft, immunotherapy, vaccinology). IMGT is freely available at http://www.imgt.org.
authors.affiliation: IMGT, the international ImMunoGeneTics information system, Université Montpellier 2, Laboratoire d'ImmunoGénétique Moléculaire LIGM, UPR CNRS 1142, Institut de Génétique Humaine IGH, 34396 Montpellier Cedex 5, France. marie-paule.lefranc@igh.cnrs.fr
authors.forename: Marie-Paule
authors.initials: MP
authors.lastname: Lefranc
authors.forename: Véronique
authors.initials: V
authors.lastname: Giudicelli
authors.forename: Chantal
authors.initials: C
authors.lastname: Ginestoux
authors.forename: Joumana
authors.initials: J
authors.lastname: Jabado-Michaloud
authors.forename: Géraldine
authors.initials: G
authors.lastname: Folch
authors.forename: Fatena
authors.initials: F
authors.lastname: Bellahcene
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.forename: Elodie
authors.initials: E
authors.lastname: Gemrot
authors.forename: Xavier
authors.initials: X
authors.lastname: Brochet
authors.forename: Jérôme
authors.initials: J
authors.lastname: Lane
authors.forename: Laetitia
authors.initials: L
authors.lastname: Regnier
authors.forename: François
authors.initials: F
authors.lastname: Ehrenmann
authors.forename: Gérard
authors.initials: G
authors.lastname: Lefranc
authors.forename: Patrice
authors.initials: P
authors.lastname: Duroux
mesh_terms: D000818:Animals; D030541:Databases, Genetic; D005803:Genes, Immunoglobulin; D019672:Genes, T-Cell Receptor; D006801:Humans; D055261:Immunogenetic Phenomena; D007136:Immunoglobulins / Q000737:chemistry; D020407:Internet; D008285:Major Histocompatibility Complex; D051379:Mice; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry; D012984:Software; D009626:Terminology as Topic
chemical_list: D007136:Immunoglobulins; D011948:Receptors, Antigen, T-Cell