title: Repeated in vitro fertilization failure and its relation with thrombophilia.
abstract: BACKGROUND
  The objective of this study was to determine the prevalence of some thrombophilic factors and its relation to in vitro fertilization (IVF)-embryo transfer failure in women who had had three or more previously failed IVF-embryo transfer cycles.
  
  
  METHODS
  The study group included 51 consecutive women with three or more previously failed IVF-embryo transfer cycles (group 1). The control group included 50 women who conceived spontaneously with at least one uneventful pregnancy and no previous history of miscarriage. All women were tested for the presence of factor V Leiden, prothrombin (G20210A), and methylenetetrahydrofolate reductase (C677T) mutations.
  
  
  RESULTS
  A similar prevalence of factor V Leiden, prothrombin, and methylenetetrahydrofolate reductase mutations was found in both groups. At least one inherited thrombophilic factor was detected in 62.7% of women with repeated IVF failure and in 53.9% of women in group 2. No association between repeated IVF failure and these thrombophilic factors was found statistically.
  
  
  CONCLUSIONS
  These data suggest that factor V Leiden, methylenetetrahydrofolate reductase and prothrombin gene mutation do not have a significant role in IVF-embryo transfer implantation failure.
authors.affiliation: Department of Obstetrics and Gynecology, Meram Medical Faculty, Selçuk University, Konya, Turkey.
authors.forename: Aynur
authors.initials: A
authors.lastname: Simur
authors.forename: Suna
authors.initials: S
authors.lastname: Ozdemir
authors.forename: Hasan
authors.initials: H
authors.lastname: Acar
authors.forename: M Cengiz
authors.initials: MC
authors.lastname: Colakoğlu
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Görkemli
authors.forename: Osman
authors.initials: O
authors.lastname: Balci
authors.forename: Süleyman
authors.initials: S
authors.lastname: Nergis
mesh_terms: D000328:Adult; D015331:Cohort Studies; D004247:DNA / Q000032:analysis; D005165:Factor V / Q000235:genetics; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods / Q000706:statistics & numerical data*; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D006801:Humans; D007247:Infertility, Female / Q000235:genetics / Q000628:therapy; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011256:Pregnancy Outcome; D015995:Prevalence; D011336:Probability; D019233:Retreatment; D018570:Risk Assessment; D018709:Statistics, Nonparametric; D019851:Thrombophilia / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*; D017211:Treatment Failure
chemical_list: C095381:factor V Leiden; D005165:Factor V; D004247:DNA