Synthesis of the analytical ligand 2-tert.-butyl-8-hydroxyquinoline.
Two methods for the synthesis of 2-tert.-butyl-8-hydroxyquinoline are described. One involves a direct reaction of the parent compound with tert.-butyl-lithium, and the other is based on a cyclization reaction of o-aminophenol with 3-chloro-4,4-dimethylpent-2-enal. Physical data confirming the structure of the compound are presented.
Thompson
M
M
Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, Canada.
Stubley
E A
EA