Lactobacillus rhamnosus LC705 together with Propionibacterium freudenreichii ssp shermanii JS administered in capsules is ineffective in lowering serum lipids.
OBJECTIVE
The aim of this study was to examine the effect of the administration of Lactobacillus rhamnosus strain LC705 and Propionibacterium freudenreichii ssp shermanii strain JS in capsules on serum cholesterol and triglyceride levels in mildly or moderately hypercholesterolemic men.


METHODS
Thirty-eight basically healthy men, mean age 42 years (range 24-55), mean cholesterol 6.2 mmol/L (5.3-8.2 mmol/L), participated in this double-blind, randomised, placebo-controlled, two-period crossover study with 4-week treatment periods. The subjects consumed daily two probiotic capsules containing viable Lactobacillus rhamnosus LC705 and Propionibacterium freudenreichii ssp shermanii JS (2 x 10(10) colony forming units of each strain daily) or two placebo capsules. Serum lipids were assessed before the intervention, at the end of both 4-week treatment periods, and 2 weeks after the second treatment period. Dietary and lifestyle habits were carefully monitored.


RESULTS
All the subjects completed the study, and the probiotic capsules were well tolerated. Dietary habits and the intake of energy and nutrients, such as saturated fatty acids and cholesterol, did not differ between the treatment groups. No changes in total cholesterol, HDL cholesterol, LDL cholesterol or triglyceride levels were observed during the consumption of the probiotics compared to placebo.


CONCLUSIONS
The administration of Lactobacillus rhamnosus LC705 and Propionibacterium freudenreichii ssp shermanii JS did not affect serum lipids.
Hatakka
Katja
K
Department of Applied Chemistry and Microbiology, Nutrition, Institute of Biomedicine, Pharmacology, University of Helsinki, Finland.
Mutanen
Marja
M
Holma
Reetta
R
Saxelin
Maija
M
Korpela
Riitta
R
D000328:Adult; D000704:Analysis of Variance; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005243:Feces / Q000382:microbiology; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000628:therapy*; D052201:Lacticaseibacillus rhamnosus / Q000302:isolation & purification; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019936:Probiotics / Q000627:therapeutic use*; D011424:Propionibacterium / Q000302:isolation & purification; D055815:Young Adult
D008055:Lipids