Buschke-Ollendorff syndrome.
BACKGROUND
Buschke-Ollendorff syndrome is a rare autosomal dominant disease featuring osteopoikilosis and skin lesions. It is caused by genetic mutations in a protein deeply involved in bone and connective tissue morphogenesis.


METHODS
We describe a 39-year-old woman with Buschke-Ollendorff syndrome.


RESULTS
After a minor trauma, radiologic examination of the left ankle of a 39-year-old woman revealed features of osteopoikilosis. Physical examination of the patient showed multiple asymptomatic nodules on both thighs, present since the age of 20 years, which had increased in size and number. Recently, a linear, string-like lesion had appeared on the right thigh.


CONCLUSIONS
The correct diagnosis of Buschke-Ollendorff syndrome may require a high index of suspicion.
Schena
Donatella
D
Department of Biomedical and Surgical Sciences, Section of Dermatology and Venereology, University of Verona, Verona, Italy. donatella.schena@azosp.vr.it
Germi
Lerica
L
Zamperetti
Maria Rosa
MR
Colato
Chiara
C
Girolomoni
Giampiero
G
D000328:Adult; D005260:Female; D006801:Humans; D007868:Leg Dermatoses / Q000175:diagnosis* / Q000473:pathology; D010023:Osteopoikilosis / Q000175:diagnosis* / Q000473:pathology; D012867:Skin / Q000473:pathology; D012873:Skin Diseases, Genetic / Q000175:diagnosis* / Q000473:pathology; D013577:Syndrome