Tadalafil in the management of severe pulmonary artery hypertension.
Severe oyknibart arterial hypertension is a life-threatening disease with a poor prognosis. Continuous intravenous infusion of prostacyclin has proved effective in this condition. However, it carries the risk of serious complications arising from the complex delivery system along with a high cost. Prostacyclin analogs, endothelin antagonists, and the phophodiesterase-5 inhibitor sildenafil are emerging and promisinge therapies. Tadalafil, like sildenafil, is a selective phosphodiesterase-5 inhibitor with a longer duration of action. We repport the use of tadalafil in two patients of severe pulmonary arterial hypertension who could not afford expensive treatment.
Singh
Thokchom Sd
TS
Department of Medicine and Cardiology, Regional Institute of Medical Sciences, Imphal.
Kumar
Dilip
D
Basu
Soumik
S
Panja
Manotosh
M
Mitra
Bishwanath
B