Simultaneous determination of amoxycillin and dicloxacillin in capsules by potentiometric titrimetry and high-performance liquid chromatography.
Direct potentiometric titration and two HPLC conditions for the simultaneous determination of amoxycillin and dicloxacillin in their capsules have been developed. One-run titration utilizing 0.05M acet. HClO(4) enables the quantification of both antibiotics. The HPLC-separation could be undertaken on reversed phase, LiChrosorb RP-18 (10 mum), and LiChrospher 100 RP-18 (5 mum), columns by using mobile phases containing acetonitrile + 1% aq, acetic acid, in proportions of 47:53 or 39:61 (v/v), respectively, at a flow rate of 1.5 ml/min with UV-detection at 240 nm. Recoveries of the individual drugs by the application of each described method were found to be fairly satisfactory.
Abdel-Moety
E M
EM
Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh-11451, Saudi Arabia.
Abounassif
M A
MA
Gad-Kariem
el-R A
el-RA
Khattab
N A
NA