Cortex shatters the glass ceiling.
Recreating developmental structures in vitro has been a primary challenge for stem cell biologists. Recent studies in Cell Stem Cell (Eiraku et al., 2008) and Nature (Gaspard et al., 2008) demonstrate that embryonic stem cells can recapitulate early cortical development, enabling them to generate specific cortical subtypes.
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Edmund
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Smilow Neuroscience Program, Department of Cell Biology, NYU Langone Medical Center, 522 First Avenue, New York, NY 10016, USA.
Fishell
Gord
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D000818:Animals; D000943:Antigens, Differentiation / Q000378:metabolism; D019521:Body Patterning; D002454:Cell Differentiation; D019070:Cell Lineage / Q000502:physiology*; D002540:Cerebral Cortex / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D053595:Embryonic Stem Cells / Q000166:cytology* / Q000502:physiology; D051858:Forkhead Transcription Factors / Q000235:genetics; D055879:Gene Knock-In Techniques; D006706:Homeostasis; D006801:Humans; D051379:Mice; D009419:Nerve Tissue Proteins / Q000235:genetics; D055495:Neurogenesis / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000378:metabolism* / Q000637:transplantation; D016875:tau Proteins / Q000235:genetics
D000943:Antigens, Differentiation; D051858:Forkhead Transcription Factors; C489565:Foxg1 protein, mouse; D009419:Nerve Tissue Proteins; D016875:tau Proteins