title: Frontal EEG for intensive care unit sedation: treating numbers or patients?
abstract: In this issue of Critical Care, Dr Haenggi and co-workers present a study evaluating bispectral index (BIS), state entropy (SE) and response entropy in 44 patients sedated in the intensive care unit (ICU). As in recent studies attempting to correlate frontal electroencephalogram (EEG) measurements with clinical evaluations of sedative efficacy, there is considerable overlap in numerical EEG values and different clinical levels of sedation. This precludes the use of these monitors for monitoring or titrating sedation in the critically ill. Despite many attempts, no study has yet presented data showing improved outcome with the use of EEG monitors in ICU sedation. Meanwhile, clinical sedation protocols have emerged, improving important endpoints in critically ill patients needing sedation. A major underlying problem in applying EEG monitors in the ICU is that they have been developed for measuring anesthetic depth and the related risk of recall, rather than the acknowledged endpoints of sedation, namely reduction of anxiety and discomfort. Until an 'objective' monitor is developed to measure the degree of such symptoms, physicians should continue treating patients and not numbers.
authors.affiliation: Department of Anesthesiology, Surgical Services and Intensive Care Medicine, Karolinska University Hospital Solna, 171 76 Stockholm, Sweden. peter.sackey@karolinska.se
authors.forename: Peter V
authors.initials: PV
authors.lastname: Sackey
mesh_terms: D004569:Electroencephalography / Q000187:drug effects / Q000379:methods*; D005625:Frontal Lobe / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology* / Q000627:therapeutic use; D007362:Intensive Care Units
chemical_list: D006993:Hypnotics and Sedatives