Time course of regional brain activation associated with onset of auditory/verbal hallucinations.
The time course of brain activation prior to onset of auditory/verbal hallucinations was characterised using functional magnetic resonance imaging in six dextral patients with schizophrenia. Composite maps of pre-hallucination periods revealed activation in the left anterior insula and in the right middle temporal gyrus, partially replicating two previous case reports, as well as deactivation in the anterior cingulate and parahippocampal gyri. These findings may reflect brain events that trigger or increase vulnerability to auditory/verbal hallucinations.
Hoffman
Ralph E
RE
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA. ralph.hoffman@yale.edu
Anderson
Adam W
AW
Varanko
Maxine
M
Gore
John C
JC
Hampson
Michelle
M
D001303:Auditory Cortex / Q000503:physiopathology; D001921:Brain / Q000503:physiopathology*; D006179:Gyrus Cinguli / Q000503:physiopathology; D006212:Hallucinations / Q000209:etiology*; D006801:Humans; D020534:Parahippocampal Gyrus / Q000503:physiopathology; D012565:Schizophrenic Psychology; D013997:Time Factors