title: Serum uric acid levels correlate with left atrial function and systolic right ventricular function in patients with newly diagnosed heart failure: the hellenic heart failure study.
abstract: The authors sought to investigate whether serum uric acid levels are associated with systolic left and right ventricular function, as well as left atrial function in patients with newly diagnosed heart failure. The authors enrolled 106 consecutive patients (mean age 65+/-13 years). Echocardiographic and biochemical assessment was performed during the third day of hospitalization. Pulsed tissue Doppler imaging of the systolic function of mitral and tricuspid annulus was characterized by the systolic waves (Smv and Stv, respectively), expressed in cm/s, and the left atrial function by the Amv wave. Left atrial kinetics was calculated using an equation. Serum uric acid levels were inversely correlated with Stv (P=.005) and left atrial kinetics (P=.05), after controlling for potential confounders. Uric acid levels appear to be correlated with more impaired right ventricular systolic function and decreased left atrial work in patients with heart failure.
authors.affiliation: First Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece. chrysohoou@usa.net
authors.forename: Christina
authors.initials: C
authors.lastname: Chrysohoou
authors.forename: Christos
authors.initials: C
authors.lastname: Pitsavos
authors.forename: John
authors.initials: J
authors.lastname: Barbetseas
authors.forename: Stella
authors.initials: S
authors.lastname: Brili
authors.forename: Iason
authors.initials: I
authors.lastname: Kotroyiannis
authors.forename: Labros
authors.initials: L
authors.lastname: Papademetriou
authors.forename: George
authors.initials: G
authors.lastname: Metallinos
authors.forename: John
authors.initials: J
authors.lastname: Skoumas
authors.forename: Costas
authors.initials: C
authors.lastname: Tentolouris
authors.forename: Christodoulos
authors.initials: C
authors.lastname: Stefanadis
mesh_terms: D000368:Aged; D018450:Disease Progression; D005260:Female; D006305:Health Status Indicators; D006325:Heart Atria / Q000000981:diagnostic imaging*; D054144:Heart Failure, Diastolic / Q000000981:diagnostic imaging / Q000503:physiopathology*; D054143:Heart Failure, Systolic / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008875:Middle Aged; D010865:Pilot Projects; D011379:Prognosis; D011446:Prospective Studies; D013599:Systole; D014463:Ultrasonography; D014527:Uric Acid / Q000097:blood*; D016278:Ventricular Function, Right
chemical_list: D014527:Uric Acid