title: ZnS quantum dots derived a reagentless uric acid biosensor.
abstract: A reagentless amperometric uric acid biosensor based on zinc sulfide (ZnS) quantum dots (QDs) was firstly developed. It could detect uric acid without the presence of an electron mediator. The carboxyl group functionalized ZnS QDs were synthesized, and they were soluble biocompatible and conductive. ZnS QDs conjugates could provide increased enzyme binding sites, which may result in higher enzyme loading. Thus, the proposed uricase/ZnS QDs/l-cys biosensor exhibited higher amperometric response compared to the one without QDs (uricase/l-cys biosensor). In addition, there was little AA interference. It showed a linear dependence on the uric acid concentration ranging from 5.0x10(-6) to 2.0x10(-3)molL(-1) with a detection limit of 2.0x10(-6)molL(-1) at 3sigma.
authors.affiliation: Department of Chemistry, East China Normal University, Shanghai 200062, China.
authors.forename: Fenfen
authors.initials: F
authors.lastname: Zhang
authors.forename: Chenxin
authors.initials: C
authors.lastname: Li
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Li
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Wang
authors.forename: Qiao
authors.initials: Q
authors.lastname: Wan
authors.forename: Yuezhong
authors.initials: Y
authors.lastname: Xian
authors.forename: Litong
authors.initials: L
authors.lastname: Jin
authors.forename: Katsunobu
authors.initials: K
authors.lastname: Yamamoto