title: Phylogenetics and pathogenesis of early avian influenza viruses (H5N1), Nigeria.
abstract: Three highly pathogenic avian influenza subtype H5N1 and 4 Newcastle disease viruses were isolated from sick or dead chickens in southwestern Nigeria. Sequencing and phylogenetic analysis placed them within H5N1 subclade 2.2.2. Intravenous and intranasal pathogenicity tests produced systemic disease with vascular endothelial cell tropism in chickens.
authors.affiliation: University of Ibadan, Ibadan, Nigeria.
authors.forename: Comfort O
authors.initials: CO
authors.lastname: Aiki-Raji
authors.forename: Patricia V
authors.initials: PV
authors.lastname: Aguilar
authors.forename: Yong-Kuk
authors.initials: YK
authors.lastname: Kwon
authors.forename: Sue
authors.initials: S
authors.lastname: Goetz
authors.forename: David L
authors.initials: DL
authors.lastname: Suarez
authors.forename: Aashish I
authors.initials: AI
authors.lastname: Jethra
authors.forename: Oyekanmi
authors.initials: O
authors.lastname: Nash
authors.forename: Christopher A O
authors.initials: CA
authors.lastname: Adeyefa
authors.forename: Festus D
authors.initials: FD
authors.lastname: Adu
authors.forename: David
authors.initials: D
authors.lastname: Swayne
authors.forename: Christopher F
authors.initials: CF
authors.lastname: Basler
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology; D002645:Chickens / Q000821:virology; D004730:Endothelium, Vascular / Q000821:virology; D007249:Inflammation / Q000473:pathology; D053124:Influenza A Virus, H5N1 Subtype / Q000145:classification* / Q000302:isolation & purification / Q000472:pathogenicity*; D005585:Influenza in Birds / Q000453:epidemiology* / Q000473:pathology / Q000821:virology*; D008168:Lung / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D009549:Nigeria / Q000453:epidemiology; D010802:Phylogeny; D014774:Virulence