title: In vivo metabolism of alpha-methyltryptamine in rats: identification of urinary metabolites.
abstract: 1. The in vivo metabolism of alpha-methyltryptamine (AMT), a psychoactive tryptamine analogue, was studied in rats. 2. Male Wistar rats were administered 10 mg kg(-1) AMT orally and 24-h urine fractions were collected. After enzymatic hydrolysis of the urine sample, the metabolites were extracted by liquid-liquid extraction and analysed by gas chromatography/mass spectrometry (GC/MS). 3. 2-Oxo-AMT, 6-hydroxy-AMT, 7-hydroxy-AMT and 1'-hydroxy-AMT were detected as metabolites of AMT.
authors.affiliation: National Research Institute of Police Science, Kashiwa, Chiba, Japan. kanamori@nrips.go.jp
authors.forename: T
authors.initials: T
authors.lastname: Kanamori
authors.forename: K
authors.initials: K
authors.lastname: Kuwayama
authors.forename: K
authors.initials: K
authors.lastname: Tsujikawa
authors.forename: H
authors.initials: H
authors.lastname: Miyaguchi
authors.forename: Y T
authors.initials: YT
authors.lastname: Iwata
authors.forename: H
authors.initials: H
authors.lastname: Inoue
mesh_terms: D000818:Animals; D008401:Gas Chromatography-Mass Spectrometry; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014363:Tryptamines / Q000008:administration & dosage / Q000378:metabolism / Q000652:urine*
chemical_list: D014363:Tryptamines; C015293:indopan