title: Higher cerebral oxygen saturation may provide higher urinary output during continuous regional cerebral perfusion.
abstract: OBJECTIVE
  We examined the hypothesis that higher cerebral oxygen saturation (rSO2) during RCP is correlated with urinary output.
  
  
  METHODS
  Between December 2002 and August 2006, 12 patients aged 3 to 61 days and weighing 2.6 to 3.4 kg underwent aortic arch repair with RCP. Urinary output and rSO2 were analyzed retrospectively. Data were assigned to either of 2 groups according to their corresponding rSO2: Group A (rSO2 < or = 75%) and Group B (rSO2 < 75%).
  
  
  RESULTS
  Seven and 5 patients were assigned to Group A and Group B, respectively.Group A was characterized by mean radial arterial pressure (37.9 +/- 9.6 vs 45.8 +/- 7.8 mmHg; P = 0.14) and femoral arterial pressure (6.7 +/- 6.1 vs 20.8 +/- 14.6 mmHg; P = 0.09) compared to Group B. However, higher urinary output during CPB (1.03 +/- 1.18 vs 0.10 +/- 0.15 ml.kg-1.h-1; P = 0.03). Furthermore our results indicate that a higher dose of Chlorpromazine was used in Group A (2.9 +/- 1.4 vs 1.7 +/- 1.0 mg/kg; P = 0.03).
  
  
  CONCLUSIONS
  Higher cerebral oxygenation may provide higher urinary output due to higher renal blood flow through collateral circulation.
authors.affiliation: Department of Cardiothoracic Surgery, Kitasato University School of Medicine, Kanagawa, Japan. yonomiyataka@msn.com
authors.forename: Takashi
authors.initials: T
authors.lastname: Miyamoto
authors.forename: Kagami
authors.initials: K
authors.lastname: Miyaji
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Okamoto
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kohira
authors.forename: Takahiro
authors.initials: T
authors.lastname: Tomoyasu
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Inoue
authors.forename: Kuniyoshi
authors.initials: K
authors.lastname: Ohara
mesh_terms: D000932:Antiemetics / Q000627:therapeutic use; D001013:Aorta, Thoracic / Q000601:surgery*; D016122:Brachiocephalic Trunk; D002315:Cardiopulmonary Bypass / Q000379:methods*; D002560:Cerebrovascular Circulation; D002746:Chlorpromazine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010100:Oxygen / Q000097:blood*; D012189:Retrospective Studies; D014554:Urination
chemical_list: D000932:Antiemetics; D010100:Oxygen; D002746:Chlorpromazine