Symmetrical drug-related intertriginous and flexural exanthema caused by valacyclovir.
Drug-related eruptions that appear only on intertriginous or flexural folds and in gluteal areas have recently been termed symmetrical drug-related intertriginous and flexural exanthema (SDRIFE). We report a case of a 56-year-old woman with acute erythematous rash in the intertriginous areas after treatment with the L-valine ester of acyclovir, valacyclovir. Oral-challenge tests resulted in erythematous pruritic rash in the intertriginous area by valacyclovir. The patient was diagnosed as having SDRIFE due to valacyclovir.
Daito
Junko
J
Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Hanada
Keiji
K
Katoh
Norito
N
Katoh
Sayoko
S
Sakamoto
Kakei
K
Asai
Jun
J
Takenaka
Hideya
H
Kishimoto
Saburo
S
D000212:Acyclovir / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D000998:Antiviral Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001365:Axilla; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005076:Exanthema / Q000139:chemically induced*; D005260:Female; D006562:Herpes Zoster / Q000150:complications / Q000188:drug therapy; D006801:Humans; D008875:Middle Aged; D009333:Neck; D000077483:Valacyclovir; D014633:Valine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*
D000998:Antiviral Agents; D014633:Valine; D000077483:Valacyclovir; D000212:Acyclovir