title: CYP2A6 allele frequencies in an Iranian population.
abstract: BACKGROUND
  Genetic polymorphism of CYP2A6 gene is a major causal factor in the large interindividual differences in nicotine metabolism. It may have an impact on smoking behavior and smoke-related cancer susceptibility. Until now, there are no reports of CYP2A6 allele frequencies in Iranian population.
  
  
  METHODS
  In the present study, we investigated the frequencies of CYP2A6 alleles in 250 male Iranians. CYP2A6*2, CYP2A6*4, CYP2A6*9, and CYP2A6*12 were determined by allele-specific polymerase chain reaction.
  
  
  RESULTS
  Frequencies of *2, *4, *9, and *12 alleles were 2.2%, 0.95%, 12.4%, and 1.34%, respectively.
  
  
  CONCLUSIONS
  These results showed that the distribution of CYP2A6 alleles in Iranian population was different from those reported previously for other ethnic groups. This highlights the importance of conducting further studies to investigate the implications on smoking dependence and cancer in Iranians.
authors.affiliation: Department of Pharmacology, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran. emamm@sums.ac.ir
authors.forename: Masoumeh
authors.initials: M
authors.lastname: Emamghoreishi
authors.forename: Hamid-Reza
authors.initials: HR
authors.lastname: Bokaee
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Keshavarz
authors.forename: Abbas
authors.initials: A
authors.lastname: Ghaderi
authors.forename: Rachel F
authors.initials: RF
authors.lastname: Tyndale
mesh_terms: D000293:Adolescent; D000328:Adult; D001189:Aryl Hydrocarbon Hydroxylases / Q000097:blood / Q000235:genetics*; D001782:Blood Donors / Q000706:statistics & numerical data; D065637:Cytochrome P-450 CYP2A6; D005787:Gene Frequency; D005828:Genetics, Population / Q000706:statistics & numerical data*; D005838:Genotype; D006801:Humans; D007492:Iran; D008297:Male; D012907:Smoking / Q000097:blood / Q000235:genetics; D055815:Young Adult
chemical_list: D001189:Aryl Hydrocarbon Hydroxylases; C585710:CYP2A6 protein, human; D065637:Cytochrome P-450 CYP2A6