Cancer cells, adipocytes and matrix metalloproteinase 11: a vicious tumor progression cycle.
This brief review focuses on the emerging role of matrix metalloproteinase 11 (MMP-11) in cancer progression. It has recently been shown that MMP-11 is induced in adipose tissue by cancer cells as they invade their surrounding environment. MMP-11 negatively regulates adipogenesis by reducing pre-adipocyte differentiation and reversing mature adipocyte differentiation. Adipocyte dedifferentiation in turn leads to the accumulation of nonmalignant peritumoral fibroblast-like cells, which favor cancer cell survival and tumor progression. This MMP-11-mediated bi-directional cross-talk between invading cancer cells and adjacent adipocytes/pre-adipocytes highlights the central role that MMP-11 plays during tumor desmoplasia and represents a molecular link between obesity and cancer.
Motrescu
Elena Roza
ER
Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR 7104, INSERM U596, ULP, C.U. de Strasbourg, BP 10142, F-67404 Illkirch Cedex, France.
Rio
Marie-Christine
MC
D017667:Adipocytes / Q000201:enzymology*; D000818:Animals; D002450:Cell Communication; D018450:Disease Progression; D006801:Humans; D053507:Matrix Metalloproteinase 11 / Q000378:metabolism*; D009367:Neoplasm Staging; D009369:Neoplasms / Q000201:enzymology* / Q000473:pathology*
D053507:Matrix Metalloproteinase 11