title: Association between NSAIDs use and breast cancer risk: a systematic review and meta-analysis.
abstract: The association between non-steroidal anti-inflammatory drugs (NSAIDs) use and breast cancer has remained controversial. Therefore, an overall quantitative estimate of the association needs to be studied. A systematic review and meta-analysis was executed to explore the pooled estimate for relative risk (RR) and 95% confidence interval (CI) using random or fixed effects models based on heterogeneity analysis. Overall 26 studies with 528,705 participants were included. The RR of NSAIDs use and the incidence of breast cancer was 0.94 (95% CI: 0.88-1.00) with random effects model. A slight reduction of breast cancer by taking aspirin and ibuprofen was both observed with pooled RR of 0.91 (95% CI: 0.83-0.98) and 0.81 (95% CI: 0.67-0.97), respectively. Our results indicate that NSAIDs use is associated with a slight decrease for the development of breast cancer with a marginally statistical significant difference. The associations are slightly more obvious in aspirin and ibuprofen use.
authors.affiliation: Department of Epidemiology, Harbin Medical University, Heilongjiang, People's Republic of China. zhao_yashuang@263.net
authors.forename: Ya-shuang
authors.initials: YS
authors.lastname: Zhao
authors.forename: Sui
authors.initials: S
authors.lastname: Zhu
authors.forename: Xiang-wei
authors.initials: XW
authors.lastname: Li
authors.forename: Fan
authors.initials: F
authors.lastname: Wang
authors.forename: Fu-lan
authors.initials: FL
authors.lastname: Hu
authors.forename: Dan-dan
authors.initials: DD
authors.lastname: Li
authors.forename: Wen-cui
authors.initials: WC
authors.lastname: Zhang
authors.forename: Xia
authors.initials: X
authors.lastname: Li
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001241:Aspirin / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000627:therapeutic use; D012307:Risk Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin; D007052:Ibuprofen