Inflammation joins the "niche".
Bone marrow-derived cells have an important role in tumor metastasis and have been reported to "prime" distant tissues for tumor engraftment, although the mechanisms for their recruitment have remained unclear. A new study by Hiratsuka et al. describes an inflammatory signaling pathway that mediates the chemoattraction of myeloid and tumor cells to organ-specific metastatic sites.
Peinado
Héctor
H
Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, NY 10021, USA.
Rafii
Shahin
S
Lyden
David
D
D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000473:pathology*; D008175:Lung Neoplasms / Q000276:immunology / Q000473:pathology* / Q000556:secondary; D022423:Myeloid Cells / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction
D014408:Biomarkers, Tumor