title: Application of artificial neural networks in multifactor optimization of an on-line microwave FIA system for catalytic kinetic determination of ruthenium (III).
abstract: A methodology based on the coupling of experimental design and artificial neural networks (ANNs) is proposed in the optimization of a flow injection system for the spectrophotometric determination of Ru (III) with m-acetylchlorophosphonazo (CPA-mA), which has been for the first time used for the optimization of high-performance capillary zone electrophoresis (J. Chromatogr. A 793 (1998) 317). And since it has been applied in many other regions like micellar electrokinetic chromatography, ion-interaction chromatography, HPLC, etc. (J. Chromatogr. A 850 (1999) 345; J. Chromatogr. A 799 (1998) 35; J. Chromatogr. A 799 (1998) 47). An orthogonal design is utilized to design the experimental protocol, in which five variables are varied simultaneously (Anal. Chim. Acta 360 (1998) 227). Feedforward-type neural networks with extended delta-bar-delta (EDBD) algorithm are applied to model the system, and the optimization of the experimental conditions is carried out in the neural network with 5-5-1 structure, which have been confirmed to be able to provide the maximum performance. In contrast to traditional methods, the use of this methodology has advantages in terms of a reduction in analysis time and an improvement in the ability of optimization. Under the optimum experimental conditions, Ru (III) can be determined in the range 0.040-0.60 mug ml(-1) with detection limit of 0.03 mug ml(-1) and the sampling frequency of 34 h(-1). The method has been applied to the determination of Ru (III) in refined ore as well as in secondary alloy and provided satisfactory results.
authors.affiliation: Department of Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China.
authors.forename: Y B
authors.initials: YB
authors.lastname: Zeng
authors.forename: H P
authors.initials: HP
authors.lastname: Xu
authors.forename: H T
authors.initials: HT
authors.lastname: Liu
authors.forename: K T
authors.initials: KT
authors.lastname: Wang
authors.forename: X G
authors.initials: XG
authors.lastname: Chen
authors.forename: Z D
authors.initials: ZD
authors.lastname: Hu
authors.forename: B T
authors.initials: BT
authors.lastname: Fan