Higher cerebral oxygen saturation may provide higher urinary output during continuous regional cerebral perfusion.
OBJECTIVE
We examined the hypothesis that higher cerebral oxygen saturation (rSO2) during RCP is correlated with urinary output.


METHODS
Between December 2002 and August 2006, 12 patients aged 3 to 61 days and weighing 2.6 to 3.4 kg underwent aortic arch repair with RCP. Urinary output and rSO2 were analyzed retrospectively. Data were assigned to either of 2 groups according to their corresponding rSO2: Group A (rSO2 < or = 75%) and Group B (rSO2 < 75%).


RESULTS
Seven and 5 patients were assigned to Group A and Group B, respectively.Group A was characterized by mean radial arterial pressure (37.9 +/- 9.6 vs 45.8 +/- 7.8 mmHg; P = 0.14) and femoral arterial pressure (6.7 +/- 6.1 vs 20.8 +/- 14.6 mmHg; P = 0.09) compared to Group B. However, higher urinary output during CPB (1.03 +/- 1.18 vs 0.10 +/- 0.15 ml.kg-1.h-1; P = 0.03). Furthermore our results indicate that a higher dose of Chlorpromazine was used in Group A (2.9 +/- 1.4 vs 1.7 +/- 1.0 mg/kg; P = 0.03).


CONCLUSIONS
Higher cerebral oxygenation may provide higher urinary output due to higher renal blood flow through collateral circulation.
Miyamoto
Takashi
T
Department of Cardiothoracic Surgery, Kitasato University School of Medicine, Kanagawa, Japan. yonomiyataka@msn.com
Miyaji
Kagami
K
Okamoto
Hirotsugu
H
Kohira
Satoshi
S
Tomoyasu
Takahiro
T
Inoue
Nobuyuki
N
Ohara
Kuniyoshi
K
D000932:Antiemetics / Q000627:therapeutic use; D001013:Aorta, Thoracic / Q000601:surgery*; D016122:Brachiocephalic Trunk; D002315:Cardiopulmonary Bypass / Q000379:methods*; D002560:Cerebrovascular Circulation; D002746:Chlorpromazine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010100:Oxygen / Q000097:blood*; D012189:Retrospective Studies; D014554:Urination
D000932:Antiemetics; D010100:Oxygen; D002746:Chlorpromazine