Natural polyphenols as proteasome modulators and their role as anti-cancer compounds.
The purpose of this review is to discuss the effect of natural antioxidant compounds as modulators of the 20S proteasome, a multi-enzymatic multi-catalytic complex present in the cytoplasm and nucleus of eukaryotic cells and involved in several cellular activities such as cell-cycle progression, proliferation and the degradation of oxidized and damaged proteins. From this perspective, proteasome inhibition is a promising approach to anticancer therapy and such natural antioxidant effectors can be considered as potential relevant adjuvants and pharmacological models in the study of new drugs.
Bonfili
Laura
L
Department of Molecular, Cellular and Animal Biology, University of Camerino, Italy.
Cecarini
Valentina
V
Amici
Manila
M
Cuccioloni
Massimiliano
M
Angeletti
Mauro
M
Keller
Jeffrey N
JN
Eleuteri
Anna M
AM
D016588:Anticarcinogenic Agents; D000970:Antineoplastic Agents; D005419:Flavonoids / Q000502:physiology*; D006801:Humans; D010636:Phenols; D059808:Polyphenols; D061988:Proteasome Inhibitors
D016588:Anticarcinogenic Agents; D000970:Antineoplastic Agents; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D061988:Proteasome Inhibitors