title: A series of new C2-symmetric amino alcohols with multicoordination groups: promising catalysts for synthesis of both enantiomers in the borane-mediated reduction of prochiral ketones.
abstract: A series of new C(2)-symmetric amino alcohols with multicoordination groups have been synthesized and successfully applied as catalysts in the borane asymmetric reduction of prochiral ketones in refluxing toluene, providing the corresponding secondary alcohols with up to 90% ee. An unusual temperature-dependent reversal of stereochemistry was also observed.
authors.affiliation: College of Chemistry and Chemical Engineering and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhou
authors.forename: Ya-Wen
authors.initials: YW
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Dou
authors.forename: Dong
authors.initials: D
authors.lastname: Zhang
authors.forename: Wei-Sheng
authors.initials: WS
authors.lastname: Liu