title: Possibilities for separation and simultaneous determination of N-unsubstituted- and N-substituted nitroimidazoles and criteria for their identification.
abstract: The N-unsubstituted nitroimidazoles have an imino hydrogen atom in contrast to the N-substituted derivatives, and react with hydroxide to give the yellow nitroimidazole anions. The difficulty of reducing the nitro-group in these anions, together with the shift of the absorption maximum to longer wavelengths makes it possible to analyse polarographically or spectrophotometrically a mixture of N-unsubstituted nitroimidazole with N-substituted derivatives. The presence of the N-unsubstituted nitroimidazole and the N-substituted derivatives is first established by chromatography. Other criteria are also proposed for distinguishing between these substances.
authors.affiliation: Research Laboratory "Galenika", Zemun, Yugoslavia.
authors.forename: D
authors.initials: D
authors.lastname: Dumanović
authors.forename: S
authors.initials: S
authors.lastname: Perkucin
authors.forename: J
authors.initials: J
authors.lastname: Volke