Determination of antihelminthic drug pyrantel pamoate in bulk and pharmaceutical formulations using electro-analytical methods.
Electrochemical behaviour of pyrantel pamoate has been studied by using different voltammetric and polarographic techniques in Britton Robinson buffer system. Differential pulse polarographic and cyclic voltammetric methods have been developed for the determination of drug in pharmaceutical formulation. A well-defined cathodic wave and one anodic peak were observed for the pyrantel pamoate in the entire pH range. Number of electrons transferred in the reduction process was calculated and the reduction mechanism postulated. The results indicate that the electrode process is reversible and diffusion controlled. The proposed method has been validated. The peak current is found to be linear over the concentration range 4x10(-4) to 2x10(-2)molL(-1). The lower detection limit (LOD) and lower limit of quantitation (LOQ) is found to be 2.45x10(-5) and 8x10(-5)molL(-1).
Jain
Rajeev
R
School of Studies in Chemistry, Jiwaji University, Gwalior 474011, India.
Jadon
Nimisha
N
Radhapyari
Keisham
K