title: [Antimicrobial effects of erythromycin microspheres against Mycoplasma Pneumoniae in rats].
abstract: OBJECTIVE
  To evaluate the antimicrobial effects of erythromycin microspheres against Mycoplasma pneumoniae in rats.
  
  
  METHODS
  With erythromycin lactobionate as the positive control, erythromycin microspheres at 3 non-toxic doses (0.1, 0.5, and 1.2 g.kg(-1).d(-1)) were administered intragastrically for 6 consecutive days in Wistar rats with Mycoplasma pneumoniae infection. The general condition and lung index of the rats were observed and measured to assess the therapeutic effects of the treatments against Mycoplasma pneumoniae infection.
  
  
  RESULTS
  The erythromycin microspheres at 0.1, 0.5, 1.2 g.kg(-1).d(-1) significantly alleviated the symptoms of the rats infected with Mycoplasma pneumoniae and reduced the pulmonary index of the infected rats from 1.75 to 1.45, 1.38 and 1.25, respectively (P < 0.01). An obvious dosage-effect relationship was noted between the dose of erythromycin microsphere and the tissue pathologies due to the infection.
  
  
  CONCLUSIONS
  Erythromycin microspheres possess strong activity against Mycoplasma pneumoniae in rats.
authors.affiliation: Department of Pharmacy, People's Hospital of Guangdong Province, Guangzhou 510080, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Wen
authors.forename: Wen-ling
authors.initials: WL
authors.lastname: Jiang
authors.forename: Ming
authors.initials: M
authors.lastname: Gong
authors.forename: Zhan-qiu
authors.initials: ZQ
authors.lastname: Yang
authors.forename: Hong
authors.initials: H
authors.lastname: Xiao
mesh_terms: D000818:Animals; D004917:Erythromycin / Q000008:administration & dosage*; D008297:Male; D008863:Microspheres; D009177:Mycoplasma pneumoniae / Q000187:drug effects*; D011019:Pneumonia, Mycoplasma / Q000188:drug therapy*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004917:Erythromycin