title: [Acute respiratory distress syndrome as the presenting manifestation of an antisynthetase syndrome].
abstract: The antisynthetase syndrome is a subgroup of idiopathic inflammatory muscle diseases. Its characteristics are interstitial lung disease, myositis, polyarthritis, mechanic's hand like cutaneous involvement, and the presence of antisynthetase antibodies (anti-Jo1). The lung disease is the presenting feature in 50% of cases. We report a patient with an antisynthetase syndrome, revealed by an acute respiratory distress syndrome. This patient was already followed-up for a scleroderma and presented a probable overlap syndrome. The disease course was favourable with anti-CD20 therapy.
authors.affiliation: Clinique de médecine interne, CHU de Grenoble, BP 217, 38700 la Tronche cedex 09, France. dfagedet@yahoo.fr
authors.forename: D
authors.initials: D
authors.lastname: Fagedet
authors.forename: S
authors.initials: S
authors.lastname: Bernard
authors.forename: B
authors.initials: B
authors.lastname: Colombe
authors.forename: A
authors.initials: A
authors.lastname: Bosseray
authors.forename: A
authors.initials: A
authors.lastname: Baudet
authors.forename: L
authors.initials: L
authors.lastname: Bouillet
authors.forename: C
authors.initials: C
authors.lastname: Massot
mesh_terms: D000604:Amino Acyl-tRNA Synthetases / Q000276:immunology; D001323:Autoantibodies / Q000097:blood; D005260:Female; D006801:Humans; D008875:Middle Aged; D017285:Polymyositis / Q000175:diagnosis* / Q000276:immunology; D012128:Respiratory Distress Syndrome / Q000209:etiology*; D013577:Syndrome
chemical_list: D001323:Autoantibodies; D000604:Amino Acyl-tRNA Synthetases