Two decades of new concepts in nitric oxide signaling: from the discovery of a gas messenger to the mediation of nonenzymatic posttranslational modifications.
For the past 20 years, nitric oxide (NO) has established itself as a gaseous free radical with crucial and unpredicted roles in a wide spectrum of biological functions and organisms. We present here a case whereby NO-mediated signaling can be broadly classified into classical (cGMP-mediated) and nonclassical, the latter mainly alluding to posttranslational modifications related to NO and its interaction with reactive groups in proteins.
Martínez-Ruiz
Antonio
A
Servicio de Inmunología, Hospital de La Princesa, c/ Diego de León 62, E-28006 Madrid, Spain. amartinezr.hlpr@salud.madrid.org
Lamas
Santiago
S
D006152:Cyclic GMP / Q000378:metabolism; D005609:Free Radicals / Q000378:metabolism; D005740:Gases / Q000378:metabolism; D008954:Models, Biological; D009569:Nitric Oxide / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000378:metabolism; D015398:Signal Transduction
D005609:Free Radicals; D005740:Gases; D011506:Proteins; D009569:Nitric Oxide; D006152:Cyclic GMP