title: Assay of cisapride in pharmaceutical formulations by extraction spectrophotometry.
abstract: Four simple and sensitive spectrophotometric methods (A-D) for the assay of cisapride in pure and dosage forms based on the formation of chloroform soluble ion-associates under specified experimental conditions are described. Four acidic dyes, namely, Suprachen Violet 3B (SV 3B, method A), Erioglaucine A (EG-A, method B), Naphthalene Blue 12 BR (NB-12BR, method C) and Tropaeolin 000 (TP 000, method D) are utilized. The extracts of the ion-associates exhibit absorption maxima at 595, 640, 620 and 500 nm for methods A, B, C and D, respectively. Beer's law and the precision and accuracy of the methods are checked by the UV reference method. The results are reproducible with an accuracy of +/-1.0%. The methods are found to be suitable for the determination of cisapride in the presence of the other ingredients that are usually present in dosage forms.
authors.affiliation: Department of Organic Chemistry, Foods, Drugs and Water, Andhra University, Visakhapatnam-530 003, India.
authors.forename: C S
authors.initials: CS
authors.lastname: Sastry
authors.forename: Y
authors.initials: Y
authors.lastname: Srinivas
authors.forename: P V
authors.initials: PV
authors.lastname: Rao