title: Systemic dermatitis due to tetrazepam.
abstract: Cutaneous adverse reactions to benzodiazepines seem to be rare. We report a 61-year-old man with adverse reactions after ingestion of metamizole, diclofenac, and tetrazepam. Skin prick tests with metamizole, diclofenac, and tetrazepam were negative. Patch tests with metamizole, diclofenac, and tetrazepam (all at 5% in aqueous solution) were performed, and were positive for tetrazepam. Oral challenge was performed with metamizole, acetylsalicylic acid, diclofenac, and tetrazepam with a positive result for diclofenac and tetrazepam. The patient tolerated other benzodiazepines. We present a patient who can tolerate diazepam but who had a type IV hypersensitivity reaction to tetrazepam confirmed by patch testing and oral challenge. The patient also presented an immediate hypersensitivity reaction after taking diclofenac.
authors.affiliation: Allergology Department, Hospital Central de la Cruz Roja, Madrid, Spain. Isanchezmorillas@hotmail.com
authors.forename: L
authors.initials: L
authors.lastname: Sánchez-Morillas
authors.forename: J J
authors.initials: JJ
authors.lastname: Laguna-Martínez
authors.forename: M
authors.initials: M
authors.lastname: Reaño-Martos
authors.forename: E
authors.initials: E
authors.lastname: Rojo-Andrés
authors.forename: P Gómez-Tembleque
authors.initials: PG
authors.lastname: Ubeda
mesh_terms: D000284:Administration, Oral; D001569:Benzodiazepines / Q000008:administration & dosage / Q000009:adverse effects*; D003286:Contracture / Q000188:drug therapy*; D003877:Dermatitis, Contact / Q000209:etiology* / Q000503:physiopathology; D004008:Diclofenac / Q000008:administration & dosage / Q000009:adverse effects; D004342:Drug Hypersensitivity / Q000150:complications*; D005076:Exanthema; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced*; D006969:Hypersensitivity, Immediate / Q000139:chemically induced*; D007114:Immunization; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D011537:Pruritus; D014581:Urticaria
chemical_list: D001569:Benzodiazepines; D004008:Diclofenac; C005245:tetrazepam