Management of malignant gliomas during pregnancy: a case series.
BACKGROUND
Limited data are available on the management of glioma in pregnant women. Therefore, the aim of the current article was to describe the outcome of women with malignant gliomas who were exposed to chemotherapy early in the gestation period of their pregnancies.


METHODS
The authors presented a case series of 6 women with malignant gliomas who during glioma-directed treatment were discovered to have an unplanned pregnancy. All patients elected to discontinue chemotherapy and carry their pregnancy to term.


RESULTS
All women had uneventful pregnancies with no glioma-related complications. All women delivered healthy newborns without evidence of congenital malformations despite exposure to cytotoxic chemotherapy and anticonvulsant medications.


CONCLUSIONS
Management of malignant glioma during pregnancy is challenging; however, normal delivery and healthy live birth is possible.
Blumenthal
Deborah T
DT
Department of Oncology, Neuro-Oncology Service, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. dvorab@tasmc.health.gov.il
Parreño
Mary Grace H
MG
Batten
Julia
J
Chamberlain
Marc C
MC
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005910:Glioma / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000401:mortality; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic
D000970:Antineoplastic Agents