Spectrophotometric methods for the determination of tolnaftate.
Two simple and sensitive visible spectrophotometric methods (methods A and B) for the determination of tolnaftate in bulk samples and formulations are described. Method A (lambda(max) 490 nm) involves the reaction of tolnaftate with 2,6-dichloroquinone-4-chlorimide (DCQC: Gibb's reagent), while method B (lambda(max) 530 nm) is based on a similar reaction of the drug with p-N,N-dimethylphenylene diamine in the presence of chloramine-T. Both these methods are applicable to pure samples as well as formulations of the drug.
Sastry
C S
CS
Foods, Drugs and Water Laboratories, School of Chemistry, Andhra University, Visakhapatnam 530 003, India.
Sastry
B S
BS
Rao
J V
JV
Krishna
R R
RR