title: From genes to psychoses and back: the role of the 5HT2alpha-receptor and prepulse inhibition in schizophrenia.
abstract: Decomposition of schizophrenia into neurobiological vulnerability traits is necessary to understand the complex genetic underpinnings of this phenomenologically defined disorder. This issue is discussed with a focus on prepulse inhibition (PPI) as a neurobiological phenotype and the 5HT2a-receptor as a candidate gene. A series of recent studies illuminates that PPI and 5HT2a-receptors present as vulnerability markers for schizophrenia; a functional sequence variant in the 5HT2a-gene is contributing to this relationship and might consequently contribute to the genetic predisposition to schizophrenia with a very small risk increase.
authors.affiliation: Klinik und Poliklinik für Psychiatrie und Psychotherapie, der Universität Bonn, Sigmund-Freud-Strasse 25, Bonn, Germany. Wolfgang.Maier@ukb.uni-bonn.de
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Maier
authors.forename: Rainald
authors.initials: R
authors.lastname: Mössner
authors.forename: Boris B
authors.initials: BB
authors.lastname: Quednow
authors.forename: Michael
authors.initials: M
authors.lastname: Wagner
authors.forename: René
authors.initials: R
authors.lastname: Hurlemann
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000818:Animals; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007266:Inhibition, Psychological; D011110:Polymorphism, Genetic; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D013216:Reflex, Startle / Q000187:drug effects / Q000235:genetics; D012559:Schizophrenia / Q000235:genetics* / Q000503:physiopathology*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; D017366:Serotonin Receptor Agonists