[Two cases of anaplastic carcinoma of the pancreas in terms of the diversity of carcinoma cells (epithelial-mesenchymal transition; EMT)].
The first evaluated case was a 71-year-old man with melaena. A huge tumor mass was observed in the tale of the pancreas, which we diagnosed as pancreatic carcinoma. Pathological findings confirmed that it was anaplastic pancreas carcinoma (giant cell type). The second case was a 61-year-old woman with upper abdominal pain. Irregular tumors with scattered cysts were observed in the tale of the pancreas, which rapidly increased. Autopsy findings confirmed that it was anaplastic pancreas carcinoma (pleomorphic type). Both cases showed positive for epithelial marker and mesenchymal markers and decrease in stainability by E-cadherin staining, a result which suggested diversity of tumor cells in anaplastic pancreas carcinomas.
Okamoto
Masaru
M
Department of Gastroenterology and Hepatology, Internal Medicine, St. Marianna University School of Medicine.
Kitajima
Satoshi
S
Negishi
Ryuujirou
R
Maehata
Tadateru
T
Kouro
Tsuyoshi
T
Yamauchi
Shunichi
S
Takahashi
Hideaki
H
Katakura
Yoshiki
Y
Watanabe
Yoshiyuki
Y
Abiko
Ryuichi
R
Nakaya
Shinichi
S
Inaba
Hiroyuki
H
Takano
Toshifumi
T
Suzuki
Michihiro
M
Itoh
Fumio
F
D015746:Abdominal Pain / Q000209:etiology; D000368:Aged; D001344:Autopsy; D014408:Biomarkers, Tumor / Q000032:analysis; D015820:Cadherins / Q000032:analysis; D002277:Carcinoma / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D003952:Diagnostic Imaging; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008297:Male; D008551:Melena / Q000209:etiology; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000150:complications / Q000175:diagnosis / Q000473:pathology*
D014408:Biomarkers, Tumor; D015820:Cadherins