title: The genetic relationship among Iranian ethnic groups: an anthropological view based on HLA class II gene polymorphism.
abstract: Highly polymorphic human leukocyte antigen (HLA) genes are considered as useful markers by molecular anthropologists to determine genetic relationship among populations. This review summarizes the results of molecular analyses of HLA class II gene polymorphism in 816 DNA samples from 11 Iranian ethnic groups. The genetic relationship of Iranians to Asians and Europeans has also been reported here. The results of this study revealed a close genetic relationship among Iranian subpopulations which were well separated from other Asian and European populations, however, a genetic similarity was observed among Iranians, Macedonians, Greeks, and Italians.
authors.affiliation: Immunology department, Shiraz University of Medical Sciences, Shiraz, Iran. farjadsh@sums.ac.ir
authors.forename: Shirin
authors.initials: S
authors.lastname: Farjadian
authors.forename: Massao
authors.initials: M
authors.lastname: Ota
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Inoko
authors.forename: Abbas
authors.initials: A
authors.lastname: Ghaderi
mesh_terms: D044467:American Indian or Alaska Native / Q000235:genetics; D044466:Asian People / Q000208:ethnology* / Q000235:genetics*; D044383:Black People / Q000235:genetics; D005006:Ethnicity / Q000208:ethnology* / Q000235:genetics*; D005787:Gene Frequency; D006683:HLA-DQ Antigens / Q000235:genetics; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D007492:Iran; D010802:Phylogeny; D011110:Polymorphism, Genetic; D044465:White People / Q000235:genetics
chemical_list: D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; C069050:HLA-DQA1 antigen; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II