CDD: specific functional annotation with the Conserved Domain Database.
NCBI's Conserved Domain Database (CDD) is a collection of multiple sequence alignments and derived database search models, which represent protein domains conserved in molecular evolution. The collection can be accessed at http://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml, and is also part of NCBI's Entrez query and retrieval system, cross-linked to numerous other resources. CDD provides annotation of domain footprints and conserved functional sites on protein sequences. Precalculated domain annotation can be retrieved for protein sequences tracked in NCBI's Entrez system, and CDD's collection of models can be queried with novel protein sequences via the CD-Search service at http://www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi. Starting with the latest version of CDD, v2.14, information from redundant and homologous domain models is summarized at a superfamily level, and domain annotation on proteins is flagged as either 'specific' (identifying molecular function with high confidence) or as 'non-specific' (identifying superfamily membership only).
Marchler-Bauer
Aron
A
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA. bauer@ncbi.nlm.nih.gov
Anderson
John B
JB
Chitsaz
Farideh
F
Derbyshire
Myra K
MK
DeWeese-Scott
Carol
C
Fong
Jessica H
JH
Geer
Lewis Y
LY
Geer
Renata C
RC
Gonzales
Noreen R
NR
Gwadz
Marc
M
He
Siqian
S
Hurwitz
David I
DI
Jackson
John D
JD
Ke
Zhaoxi
Z
Lanczycki
Christopher J
CJ
Liebert
Cynthia A
CA
Liu
Chunlei
C
Lu
Fu
F
Lu
Shennan
S
Marchler
Gabriele H
GH
Mullokandov
Mikhail
M
Song
James S
JS
Tasneem
Asba
A
Thanki
Narmada
N
Yamashita
Roxanne A
RA
Zhang
Dachuan
D
Zhang
Naigong
N
Bryant
Stephen H
SH
D000595:Amino Acid Sequence; D017124:Conserved Sequence; D030562:Databases, Protein; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000145:classification; D016415:Sequence Alignment; D020539:Sequence Analysis, Protein
D011506:Proteins