title: Preventive effects of total flavonoids of Litsea coreana leve on hepatic steatosis in rats fed with high fat diet.
abstract: OBJECTIVE
  To evaluate the protective effects of total flavonoids of Litsea Coreana leve (TFLC) on rat high fat diet-induced hepatic steatosis model.
  
  
  METHODS
  Rats were given either a high fat diet alone or the same diet plus TFLC for 4 weeks.
  
  
  RESULTS
  TFLC improved liver histology with reduced serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), as well as decreased the over accumulation lipids in serum and liver. TFLC increased serum levels of leptin and insulin, while decreased serum TNFalpha level in high fat diet fed rat. Furthermore, TFLC was found increased the expression of peroxisome proliferator-activated receptor alpha (PPARalpha) in high fat diet fed rat liver. These benefits were associated with increased superoxide dismutase (SOD) and decreased malondialdehyde (MDA) in high fat diet fed rat liver.
  
  
  CONCLUSIONS
  TFLC exerts protective effects against hepatic steatosis in rats fed with high fat diet possibly through its antioxidant actions, improving the adipocytokines release and increasing the expression of PPARalpha.
authors.affiliation: School of Pharmacy, Anhui Medical University, Hefei, Anhui, China.
authors.forename: Jian-Qing
authors.initials: JQ
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Yu-Hong
authors.initials: YH
authors.lastname: Zou
authors.forename: Wen-Ming
authors.initials: WM
authors.lastname: Cheng
authors.forename: Chao
authors.initials: C
authors.lastname: Lu
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Jin-Fang
authors.initials: JF
authors.lastname: Ge
authors.forename: Cheng
authors.initials: C
authors.lastname: Huang
authors.forename: Yong
authors.initials: Y
authors.lastname: Jin
authors.forename: Xiong-Wen
authors.initials: XW
authors.lastname: Lv
authors.forename: Cheng-Mu
authors.initials: CM
authors.lastname: Hu
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Liu
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D001219:Aspartate Aminotransferases / Q000378:metabolism; D004041:Dietary Fats / Q000008:administration & dosage; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use; D005234:Fatty Liver / Q000201:enzymology / Q000209:etiology / Q000517:prevention & control*; D005419:Flavonoids / Q000494:pharmacology / Q000627:therapeutic use*; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D032862:Litsea / Q000737:chemistry*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008517:Phytotherapy; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000975:Antioxidants; D004041:Dietary Fats; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D007328:Insulin; D020738:Leptin; D014409:Tumor Necrosis Factor-alpha; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase