title: Relationship between aortic isthmus and ductus venosus velocity waveforms in severe growth restricted fetuses.
abstract: OBJECTIVE
  To evaluate the incidence of abnormalities in velocity waveforms from ductus venosus (DV) and aortic isthmus (AoI) in fetuses with intrauterine growth restriction (IUGR) and their reciprocal temporal relationship.
  
  
  METHODS
  DV and AoI velocity waveforms were recorded in 31 IUGR fetuses characterized either by absent end diastolic (20) or reverse flow (11) in umbilical artery. Abnormal velocity waveforms in DV and AoI were defined in presence of reverse diastolic flows.
  
  
  RESULTS
  Abnormal DV velocity waveforms were present in 10 fetuses and were always associated with abnormalities. Abnormal AoI flows were also present in 10 fetuses of the remaining 21 fetuses with normal DV velocity waveforms (47.6%). Longitudinal monitoring of fetuses with normal DV flows showed a significantly shorter time interval in the onset of reverse flow in DV when abnormalities in AoI were present (4 vs 14 days p=0.001) irrespectively of gestational age or other potential confounding variables.
  
  
  CONCLUSIONS
  Our data suggest that AoI velocity waveforms become abnormal at an earlier stage of fetal compromise than DV.
authors.affiliation: Department Obstetrics and Gynecology, Università di Roma Tor Vergata, Italy. giuseppe.rizzo@uniroma2.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Rizzo
authors.forename: Alessandra
authors.initials: A
authors.lastname: Capponi
authors.forename: Marianne
authors.initials: M
authors.lastname: Vendola
authors.forename: Maria Elena
authors.initials: ME
authors.lastname: Pietrolucci
authors.forename: Domenico
authors.initials: D
authors.lastname: Arduini
mesh_terms: D001013:Aorta, Thoracic / Q000000981:diagnostic imaging / Q000196:embryology; D001034:Apgar Score; D001724:Birth Weight; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging / Q000453:epidemiology; D036861:Delivery, Obstetric; D005260:Female; D005313:Fetal Death; D005317:Fetal Growth Retardation / Q000000981:diagnostic imaging* / Q000401:mortality; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D015999:Multivariate Analysis; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D016216:Ultrasonography, Prenatal