Preparation of d-(-)trans-1,2-diaminocyclohexane-N,N,N'N'-tetra-acetic acid and its use as a spectropolarimetric reagent for lead.
d-(-)-trans-1,2-diaminocyclohexane-N, N, N', N' -tetraacetic acid [d(-)DCTA] was prepared stereospecifically in good yield by the condensation of the resolved diamine, d-(-)-trans-1,2-diaminocyclohexane, with sodium chloroacetate at 16 degrees , followed by use of a strong cation-exchanger to obtain the free acid. Distinct differences were noted in the infrared spectra of the optically active acid and the racemate. The molecular rotation of d(-)DCTA showed strong dependence on the pH of the solution. D(-)DCTA was used as a stereospecific chelometric reagent in the spectropolarimetrically monitored determination of lead.
Reinbold
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Department of Chemistry, Texas A & M University, College Station, Texas 77843, U.S.A.
Pearson
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