Estradiol valerate as a possible endocrine reproductive disruptor: evidence from an in vivo rat model.
We used an in vivo rat model to demonstrate that low-dose intradermal exposure to E(2) valerate has an inverse effect on the female's estrus cycle pattern and can significantly reduce litter size. These results suggest that, under certain circumstances, environmental exposure to exogenous estrogens may play a role as an endocrine disruptor and adversely affect reproductive outcome.
Seidman
Daniel S
DS
Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, both affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. dseidman@post.tau.ac.il
Itsekson
Alek
A
Alesker
Michael
M
Zolti
Mati
M
Carp
Howard
H
Wolman
Igal
I
D000818:Animals; D003270:Contraceptive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure / Q000009:adverse effects; D004958:Estradiol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D004971:Estrus / Q000187:drug effects* / Q000502:physiology; D005260:Female; D007271:Injections, Intradermal; D008098:Litter Size / Q000187:drug effects; D023421:Models, Animal; D051381:Rats; D011921:Rats, Inbred WKY; D012098:Reproduction / Q000187:drug effects* / Q000502:physiology; D012867:Skin / Q000276:immunology
D003270:Contraceptive Agents; D004958:Estradiol