A rapid method for the determination of some antihypertensive and antipyretic drugs by thermometric titrimetry.
A simple and rapid method is described for the direct thermometric determination of milligram amounts of methyl dopa, propranolol hydrochloride, 1-phenyl-3-methylpyrazolone (MPP) and 2,3-dimethyl-1-phenylpyrazol-5-one (phenazone) in the presence of excipients. The compounds are reacted with N'-bromosuccinimide and the heat of reaction is used to determine the end-point of the titration. The time required is approximately 2 min, and the accuracy is analytically acceptable.
Abbasi
U M
UM
Department of Analytical Chemistry, Institute of Chemistry University of Sind, Jamshoro, Sind, Pakistan.
Chand
F
F
Bhanger
M I
MI
Memon
S A
SA