title: [The association of tyrosine hydroxylase gene polymorphism with mental disorder].
abstract: OBJECTIVE
  To evaluate the relationship between the tyrosine hydroxylase (TH) gene and mental disorder by comparing the two TH gene SNP points (extron 3 and intron 9) of patients with mental disorders and normal human.
  
  
  METHODS
  DNA extracted from specimens of patients and normal subjects were quantified by using Real-time PCR.
  
  
  RESULTS
  (1) G334A distribution was: G=0.133, A=0.867 in patients with schizophrenia, G=0.116, A=0.884 in patients with depression, and G=0.214, A=0.786 in normal group. (2) C5162G distribution was: C=0.962, G=0.038 in patients with schizophrenia, C=0.959, G=0.041 in patients with depression, and C=0.961, G=0.039 in normal group.
  
  
  CONCLUSIONS
  There are statistically significant differences in G334A locus between normal people and patients with mental disorders, but no statistically significant differences in C5162G locus.
authors.affiliation: School of Forensic Medicine, China Medical University, Shenyang 110001, China. yujian0905@sina.com
authors.forename: Jian
authors.initials: J
authors.lastname: Yu
authors.forename: Hao
authors.initials: H
authors.lastname: Pang
authors.forename: Bao-Jie
authors.initials: BJ
authors.lastname: Wang
mesh_terms: D003866:Depressive Disorder / Q000201:enzymology / Q000235:genetics; D005260:Female; D053803:Forensic Genetics; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000201:enzymology* / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012559:Schizophrenia / Q000201:enzymology / Q000235:genetics; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics*
chemical_list: D014446:Tyrosine 3-Monooxygenase