title: Pediatric cardiopulmonary resuscitation: advances in science, techniques, and outcomes.
abstract: More than 25% of children survive to hospital discharge after in-hospital cardiac arrests, and 5% to 10% survive after out-of-hospital cardiac arrests. This review of pediatric cardiopulmonary resuscitation addresses the epidemiology of pediatric cardiac arrests, mechanisms of coronary blood flow during cardiopulmonary resuscitation, the 4 phases of cardiac arrest resuscitation, appropriate interventions during each phase, special resuscitation circumstances, extracorporeal membrane oxygenation cardiopulmonary resuscitation, and quality of cardiopulmonary resuscitation. The key elements of pathophysiology that impact and match the timing, intensity, duration, and variability of the hypoxic-ischemic insult to evidence-based interventions are reviewed. Exciting discoveries in basic and applied-science laboratories are now relevant for specific subpopulations of pediatric cardiac arrest victims and circumstances (eg, ventricular fibrillation, neonates, congenital heart disease, extracorporeal cardiopulmonary resuscitation). Improving the quality of interventions is increasingly recognized as a key factor for improving outcomes. Evolving training strategies include simulation training, just-in-time and just-in-place training, and crisis-team training. The difficult issue of when to discontinue resuscitative efforts is addressed. Outcomes from pediatric cardiac arrests are improving. Advances in resuscitation science and state-of-the-art implementation techniques provide the opportunity for further improvement in outcomes among children after cardiac arrest.
authors.affiliation: Department of Anesthesia and Critical Care Medicine, University of Pennsylvania, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA. topjian@email.chop.edu
authors.forename: Alexis A
authors.initials: AA
authors.lastname: Topjian
authors.forename: Robert A
authors.initials: RA
authors.lastname: Berg
authors.forename: Vinay M
authors.initials: VM
authors.lastname: Nadkarni
mesh_terms: D000818:Animals; D001794:Blood Pressure; D016887:Cardiopulmonary Resuscitation; D002648:Child; D015199:Extracorporeal Membrane Oxygenation; D006323:Heart Arrest / Q000453:epidemiology / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008020:Life Support Care; D008279:Magnetic Resonance Imaging; D009414:Nerve Growth Factors / Q000097:blood; D054318:No-Reflow Phenomenon / Q000503:physiopathology; D011379:Prognosis; D011788:Quality of Life; D012039:Regional Blood Flow; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood; D014655:Vascular Resistance; D014693:Ventricular Fibrillation / Q000453:epidemiology / Q000503:physiopathology
chemical_list: D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins