Michigan molecular interactions r2: from interacting proteins to pathways.
Molecular interaction data exists in a number of repositories, each with its own data format, molecule identifier and information coverage. Michigan molecular interactions (MiMI) assists scientists searching through this profusion of molecular interaction data. The original release of MiMI gathered data from well-known protein interaction databases, and deep merged this information while keeping track of provenance. Based on the feedback received from users, MiMI has been completely redesigned. This article describes the resulting MiMI Release 2 (MiMIr2). New functionality includes extension from proteins to genes and to pathways; identification of highlighted sentences in source publications; seamless two-way linkage with Cytoscape; query facilities based on MeSH/GO terms and other concepts; approximate graph matching to find relevant pathways; support for querying in bulk; and a user focus-group driven interface design. MiMI is part of the NIH's; National Center for Integrative Biomedical Informatics (NCIBI) and is publicly available at: http://mimi.ncibi.org.
Tarcea
V Glenn
VG
Center for Computational Medicine and Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Weymouth
Terry
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Ade
Alex
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Bookvich
Aaron
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Gao
Jing
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Mahavisno
Vasudeva
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Wright
Zach
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Chapman
Adriane
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Jayapandian
Magesh
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Ozgür
Arzucan
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Tian
Yuanyuan
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Cavalcoli
Jim
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Mirel
Barbara
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Patel
Jignesh
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Radev
Dragomir
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Athey
Brian
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States
David
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Jagadish
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D003196:Computer Graphics; D030562:Databases, Protein; D025941:Protein Interaction Mapping; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D014584:User-Computer Interface
D011506:Proteins