title: Homogeneous sulfation of bagasse cellulose in an ionic liquid and anticoagulation activity.
abstract: Homogeneous sulfation of bagasse cellulose (BC) with chlorosulfonic acid-dimethylformamide was accomplished in an ionic liquid 1-butyl-3-methylimidazolium chloride ([C(4)mim]Cl). The BCS products from the sulfation had degrees of substitution (DS) in the range of 0.52-2.95 and a simultaneous substitution pattern at C-6, C-2 and C-3 positions. The sulfated BCS attained significant anticoagulation activity, causing a dose-dependent prolongation of coagulation time and inhibition of FIIa and FXa activities in human plasma. The anticoagulation activity of BCS showed a positive correlation with DS, and some of the activity indexes exceeded those of heparin.
authors.affiliation: Research Institute of Light Industry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China.
authors.forename: Zhao-Mei
authors.initials: ZM
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.forename: Kai-Jun
authors.initials: KJ
authors.lastname: Xiao
authors.forename: Jian-Yong
authors.initials: JY
authors.lastname: Wu
mesh_terms: D000925:Anticoagulants / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects; D002482:Cellulose / Q000378:metabolism* / Q000494:pharmacology*; D015956:Factor XIIa / Q000037:antagonists & inhibitors; D065427:Factor Xa Inhibitors; D006493:Heparin / Q000378:metabolism; D006801:Humans; D052578:Ionic Liquids / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D013431:Sulfates / Q000378:metabolism*; D013918:Thrombin Time
chemical_list: D000925:Anticoagulants; D065427:Factor Xa Inhibitors; D052578:Ionic Liquids; D013431:Sulfates; D002482:Cellulose; D006493:Heparin; C027433:bagasse; D015956:Factor XIIa