Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones.
Copper (II) chloride in the absence of any solvent, efficiently catalyses the synthesis of dihydropyrimidinones (80-96% yields) by the Biginelli reaction. Six compounds were selected and examined their antifungal activities against the radial growth of three fungal species viz., Trichoderma hammatum, Trichoderma koningii and Aspergillus niger.
Singh
Okram Mukherjee
OM
Department of Chemistry, Manipur University, Canchipur, Imphal 795003, Manipur, India. ok_mukherjee@yahoo.co.in
Singh
Sarangthem Joychandra
SJ
Devi
Mutum Babita
MB
Devi
Laitonjam Nalini
LN
Singh
Nameirakpam Irabanta
NI
Lee
Sang-Gyeong
SG
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001234:Aspergillus niger / Q000378:metabolism; D002384:Catalysis; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003300:Copper / Q000737:chemistry; D015195:Drug Design; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D011744:Pyrimidinones / Q000138:chemical synthesis / Q000494:pharmacology*; D012997:Solvents / Q000737:chemistry; D013997:Time Factors; D014242:Trichoderma / Q000378:metabolism
D000935:Antifungal Agents; D011744:Pyrimidinones; D012997:Solvents; D003300:Copper; C029892:cupric chloride