title: Model-based segmentation of hippocampal subfields in ultra-high resolution in vivo MRI.
abstract: Recent developments in MR data acquisition technology are starting to yield images that show anatomical features of the hippocampal formation at an unprecedented level of detail, providing the basis for hippocampal subfield measurement. Because of the role of the hippocampus in human memory and its implication in a variety of disorders and conditions, the ability to reliably and efficiently quantify its subfields through in vivo neuroimaging is of great interest to both basic neuroscience and clinical research. In this paper, we propose a fully-automated method for segmenting the hippocampal subfields in ultra-high resolution MRI data. Using a Bayesian approach, we build a computational model of how images around the hippocampal area are generated, and use this model to obtain automated segmentations. We validate the proposed technique by comparing our segmentation results with corresponding manual delineations in ultra-high resolution MRI scans of five individuals.
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, MGH, Harvard Medical School, USA.
authors.forename: Koen
authors.initials: K
authors.lastname: Van Leemput
authors.forename: Akram
authors.initials: A
authors.lastname: Bakkour
authors.forename: Thomas
authors.initials: T
authors.lastname: Benner
authors.forename: Graham
authors.initials: G
authors.lastname: Wiggins
authors.forename: Lawrence L
authors.initials: LL
authors.lastname: Wald
authors.forename: Jean
authors.initials: J
authors.lastname: Augustinack
authors.forename: Bradford C
authors.initials: BC
authors.lastname: Dickerson
authors.forename: Polina
authors.initials: P
authors.lastname: Golland
authors.forename: Bruce
authors.initials: B
authors.lastname: Fischl
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D016000:Cluster Analysis; D003198:Computer Simulation; D006624:Hippocampus / Q000033:anatomy & histology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008954:Models, Biological; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity