title: Trans-rectal ultrasound-coupled near-infrared optical tomography of the prostate, part II: experimental demonstration.
abstract: We demonstrate trans-rectal optical tomography of the prostate using an endo-rectal near-infrared (NIR) applicator integrated with a transrectal ultrasound (TRUS) probe. The endo-rectal NIR applicator incorporated a design presented in our previously reported work. A continuous-wave NIR optical tomography system is combined with a commercial US scanner to form the dual-modality imager. Sagittal transrectal imaging is performed concurrently by endo-rectal NIR and TRUS. The TRUS ensures accurate positioning of the NIR applicator as well as guides NIR image reconstruction using the spatial prior of the target. The use of a condom, which is standard for TRUS, is found to have minimal effect on trans-rectal NIR imaging. Tests on avian tissues validates that NIR imaging can recover the absorption contrast of a target, and its accuracy is improved when the TRUS spatial prior is incorporated. Trans-rectal NIR/US imaging of a healthy canine prostate in situ is reported.
authors.affiliation: School of Electrical and Computer Engineering, Oklahoma State University, Stillwater, OK 74078, USA.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Jiang
authors.forename: Daqing
authors.initials: D
authors.lastname: Piao
authors.forename: Guan
authors.initials: G
authors.lastname: Xu
authors.forename: Jerry W
authors.initials: JW
authors.lastname: Ritchey
authors.forename: G Reed
authors.initials: GR
authors.lastname: Holyoak
authors.forename: Kenneth E
authors.initials: KE
authors.lastname: Bartels
authors.forename: Charles F
authors.initials: CF
authors.lastname: Bunting
authors.forename: Gennady
authors.initials: G
authors.lastname: Slobodov
authors.forename: Jerzy S
authors.initials: JS
authors.lastname: Krasinski
mesh_terms: D000818:Animals; D002138:Calibration; D002645:Chickens; D004285:Dogs; D007259:Infrared Rays; D008297:Male; D019047:Phantoms, Imaging; D011467:Prostate / Q000000981:diagnostic imaging*; D012007:Rectum / Q000000981:diagnostic imaging*; D041622:Tomography, Optical / Q000295:instrumentation*; D014463:Ultrasonography