title: [Elevation of PSA after prostate radiotherapy: rebound or biochemical recurrence?].
abstract: The fact that external beam radiotherapy and brachytherapy are now considered to be curative techniques has led to major review of the modalities of follow-up after radiotherapy for prostate cancer. The problem concerns both the diagnosis of recurrence, rapidly announced by elevation of prostatic-specific antigen (PSA), usually at a subclinical stage, and the validity of criteria of biochemical recurrence to allow comparison of various study. Physicians involved in follow-up should be aware of the potential of bounce in PSA follow-up after external beam radiotherapy or brachytherapy. The PSA bounce phenomemon was defined by a rise of PSA values (+0.1 -0.8 ng/ml) with a subsequent fall. Biochemical failure after external beam radiotherapy or brachytherapy (with or without hormonotherapy) was defined by Phoenix criteria by a rise of 2 ng/ml above an initial PSA nadir. This definition was more correlated to PSA bounce phenomenon.
authors.affiliation: Centre de radiothérapie, clinique Hartmann, 26, boulevard Victor-Hugo, 92200 Neuilly-sur-Seine, France.
authors.forename: A
authors.initials: A
authors.lastname: Toledano
authors.forename: R
authors.initials: R
authors.lastname: Chiche
authors.forename: H
authors.initials: H
authors.lastname: Lamallem
authors.forename: A
authors.initials: A
authors.lastname: Kanoui
authors.forename: S
authors.initials: S
authors.lastname: Beley
authors.forename: F
authors.initials: F
authors.lastname: Thibault
authors.forename: P
authors.initials: P
authors.lastname: Sèbe
mesh_terms: D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000097:blood* / Q000175:diagnosis; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000532:radiotherapy*
chemical_list: D017430:Prostate-Specific Antigen