title: Real-time chemical responses in the nucleus accumbens differentiate rewarding and aversive stimuli.
abstract: Rewarding and aversive stimuli evoke very different patterns of behavior and are rapidly discriminated. Here taste stimuli of opposite hedonic valence evoked opposite patterns of dopamine and metabolic activity within milliseconds in the nucleus accumbens. This rapid encoding may serve to guide ongoing behavioral responses and promote plastic changes in underlying circuitry.
authors.affiliation: Department of Psychology, University of Illinois, Chicago, Illinois 60607, USA. mroitman@uic.edu
authors.forename: Mitchell F
authors.initials: MF
authors.lastname: Roitman
authors.forename: Robert A
authors.initials: RA
authors.lastname: Wheeler
authors.forename: R Mark
authors.initials: RM
authors.lastname: Wightman
authors.forename: Regina M
authors.initials: RM
authors.lastname: Carelli
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001066:Appetite / Q000502:physiology; D001362:Avoidance Learning / Q000502:physiology*; D001522:Behavior, Animal; D004192:Discrimination, Psychological / Q000502:physiology*; D004298:Dopamine / Q000378:metabolism*; D004558:Electric Stimulation / Q000379:methods; D055664:Electrochemical Techniques / Q000379:methods; D005518:Food Preferences / Q000502:physiology; D006863:Hydrogen-Ion Concentration; D008297:Male; D009043:Motor Activity / Q000502:physiology; D009714:Nucleus Accumbens / Q000502:physiology*; D025341:Principal Component Analysis; D011803:Quinine / Q000008:administration & dosage; D051381:Rats; D017207:Rats, Sprague-Dawley; D012201:Reward; D013395:Sucrose / Q000008:administration & dosage; D013549:Sweetening Agents / Q000008:administration & dosage; D013649:Taste / Q000502:physiology; D013997:Time Factors
chemical_list: D013549:Sweetening Agents; D013395:Sucrose; D011803:Quinine; D004298:Dopamine