title: A risk score to predict intracranial hemorrhage after recombinant tissue plasminogen activator for acute ischemic stroke.
abstract: BACKGROUND
  Ability to predict risk of postthrombolysis intracerebral hemorrhage (ICH) is currently limited.
  
  
  METHODS
  Using data from the Multicenter Recombinant Tissue Plasminogen Activator Stroke Survey Group, we developed a score to predict this risk. One point was assigned for the presence of each of 4 variables: age older than 60 years, baseline National Institutes of Health Stroke Scale score greater than 10, glucose greater than 8.325 mmol/L, and platelet count less than 150,000/mm(3).
  
  
  RESULTS
  Rate of any ICH increased with higher scores: 0 points, 2.6%; 1 point, 9.7%; 2 points, 15.1%; and greater than or equal to 3 points, 37.9%. The model had reasonable discriminatory capability (C-statistic 0.69). A similar pattern was seen with symptomatic and asymptomatic ICH separately, and with radiographically defined parenchymal hemorrhage.
  
  
  CONCLUSIONS
  A simple risk score may be useful for predicting postthrombolysis ICH.
authors.affiliation: Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104, USA. cucchiar@mail.med.upenn.edu
authors.forename: Brett
authors.initials: B
authors.lastname: Cucchiara
authors.forename: David
authors.initials: D
authors.lastname: Tanne
authors.forename: Steven R
authors.initials: SR
authors.lastname: Levine
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Demchuk
authors.forename: Scott
authors.initials: S
authors.lastname: Kasner
mesh_terms: D000367:Age Factors; D001778:Blood Coagulation Disorders; D002545:Brain Ischemia / Q000188:drug therapy*; D002533:Cerebral Angiography; D002536:Cerebral Arteries / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology; D002543:Cerebral Hemorrhage / Q000139:chemically induced* / Q000453:epidemiology*; D005343:Fibrinolytic Agents / Q000009:adverse effects; D006801:Humans; D006943:Hyperglycemia / Q000453:epidemiology; D018579:Patient Selection; D010976:Platelet Count; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D020521:Stroke / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000009:adverse effects*
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator