title: Natural polyphenols as proteasome modulators and their role as anti-cancer compounds.
abstract: The purpose of this review is to discuss the effect of natural antioxidant compounds as modulators of the 20S proteasome, a multi-enzymatic multi-catalytic complex present in the cytoplasm and nucleus of eukaryotic cells and involved in several cellular activities such as cell-cycle progression, proliferation and the degradation of oxidized and damaged proteins. From this perspective, proteasome inhibition is a promising approach to anticancer therapy and such natural antioxidant effectors can be considered as potential relevant adjuvants and pharmacological models in the study of new drugs.
authors.affiliation: Department of Molecular, Cellular and Animal Biology, University of Camerino, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Bonfili
authors.forename: Valentina
authors.initials: V
authors.lastname: Cecarini
authors.forename: Manila
authors.initials: M
authors.lastname: Amici
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Cuccioloni
authors.forename: Mauro
authors.initials: M
authors.lastname: Angeletti
authors.forename: Jeffrey N
authors.initials: JN
authors.lastname: Keller
authors.forename: Anna M
authors.initials: AM
authors.lastname: Eleuteri
mesh_terms: D016588:Anticarcinogenic Agents; D000970:Antineoplastic Agents; D005419:Flavonoids / Q000502:physiology*; D006801:Humans; D010636:Phenols; D059808:Polyphenols; D061988:Proteasome Inhibitors
chemical_list: D016588:Anticarcinogenic Agents; D000970:Antineoplastic Agents; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D061988:Proteasome Inhibitors