title: CDD: specific functional annotation with the Conserved Domain Database.
abstract: NCBI's Conserved Domain Database (CDD) is a collection of multiple sequence alignments and derived database search models, which represent protein domains conserved in molecular evolution. The collection can be accessed at http://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml, and is also part of NCBI's Entrez query and retrieval system, cross-linked to numerous other resources. CDD provides annotation of domain footprints and conserved functional sites on protein sequences. Precalculated domain annotation can be retrieved for protein sequences tracked in NCBI's Entrez system, and CDD's collection of models can be queried with novel protein sequences via the CD-Search service at http://www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi. Starting with the latest version of CDD, v2.14, information from redundant and homologous domain models is summarized at a superfamily level, and domain annotation on proteins is flagged as either 'specific' (identifying molecular function with high confidence) or as 'non-specific' (identifying superfamily membership only).
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA. bauer@ncbi.nlm.nih.gov
authors.forename: Aron
authors.initials: A
authors.lastname: Marchler-Bauer
authors.forename: John B
authors.initials: JB
authors.lastname: Anderson
authors.forename: Farideh
authors.initials: F
authors.lastname: Chitsaz
authors.forename: Myra K
authors.initials: MK
authors.lastname: Derbyshire
authors.forename: Carol
authors.initials: C
authors.lastname: DeWeese-Scott
authors.forename: Jessica H
authors.initials: JH
authors.lastname: Fong
authors.forename: Lewis Y
authors.initials: LY
authors.lastname: Geer
authors.forename: Renata C
authors.initials: RC
authors.lastname: Geer
authors.forename: Noreen R
authors.initials: NR
authors.lastname: Gonzales
authors.forename: Marc
authors.initials: M
authors.lastname: Gwadz
authors.forename: Siqian
authors.initials: S
authors.lastname: He
authors.forename: David I
authors.initials: DI
authors.lastname: Hurwitz
authors.forename: John D
authors.initials: JD
authors.lastname: Jackson
authors.forename: Zhaoxi
authors.initials: Z
authors.lastname: Ke
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Lanczycki
authors.forename: Cynthia A
authors.initials: CA
authors.lastname: Liebert
authors.forename: Chunlei
authors.initials: C
authors.lastname: Liu
authors.forename: Fu
authors.initials: F
authors.lastname: Lu
authors.forename: Shennan
authors.initials: S
authors.lastname: Lu
authors.forename: Gabriele H
authors.initials: GH
authors.lastname: Marchler
authors.forename: Mikhail
authors.initials: M
authors.lastname: Mullokandov
authors.forename: James S
authors.initials: JS
authors.lastname: Song
authors.forename: Asba
authors.initials: A
authors.lastname: Tasneem
authors.forename: Narmada
authors.initials: N
authors.lastname: Thanki
authors.forename: Roxanne A
authors.initials: RA
authors.lastname: Yamashita
authors.forename: Dachuan
authors.initials: D
authors.lastname: Zhang
authors.forename: Naigong
authors.initials: N
authors.lastname: Zhang
authors.forename: Stephen H
authors.initials: SH
authors.lastname: Bryant
mesh_terms: D000595:Amino Acid Sequence; D017124:Conserved Sequence; D030562:Databases, Protein; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000145:classification; D016415:Sequence Alignment; D020539:Sequence Analysis, Protein
chemical_list: D011506:Proteins