Novel synthetic luteolin analogue-caused sensitization of tumor necrosis factor-alpha-induced apoptosis in human tumor cells.
Studies on the sensitization, by novel alkynyl luteolin analogues, of TNF-alpha-induced apoptosis in HeLa and HepG2 cells revealed that LA-12 showed better sensitizing effects on TNF-alpha-induced cell death than luteolin, suggesting great potential for alkynyl luteolin analogues in cancer therapy.
Cheng
Lili
L
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543, Republic of Singapore.
Tan
Huiling
H
Wu
Xiaoyu
X
Hu
Ruijun
R
Aw
Carlin
C
Zhao
Min
M
Shen
Han-Ming
HM
Lu
Yixin
Y
D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D015195:Drug Design; D006801:Humans; D047311:Luteolin / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009369:Neoplasms / Q000473:pathology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism / Q000494:pharmacology*
D014409:Tumor Necrosis Factor-alpha; D047311:Luteolin