Chemiluminescence detection of sodium nitroprusside using flow injection analysis.
A simple continuous-flow chemiluminometric method for the determination of 0.05-10 microg/ml of sodium nitroprusside is described. The method is based on the catalyses of luminol oxidation by hydrogen peroxide in alkaline medium. The method is sensitive and requires no sample pre-treatment and solutions can be analysed at a rate of 40 samples/hr with a relative error of about 1.18%. The method was satisfactory for the determination of sodium nitroprusside in a pharmaceutical preparation. The effect of some potential interferents is described.
Alwarthan
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Chemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.