Preparation of hierarchical hollow CaCO3 particles and the application as anticancer drug carrier.
One-pot approach to couple the crystallization of CaCO(3) nanoparticles and the in situ symmetry-breaking assembly of these crystallites into hollow spherical shells was developed under the templating effect of a soluble starch. Further functional study using HP-a as an anticancer drug carrier (DOX) demonstrated its advantages for localizing drug release by the pH value-sensitive structure and enhancing cytotoxicity by increasing cellular uptake, perinuclear accumulation, and nuclear entry.
Wei
Wei
W
Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, PR China.
Ma
Guang-Hui
GH
Hu
Gang
G
Yu
Di
D
McLeish
Tom
T
Su
Zhi-Guo
ZG
Shen
Zhe-Yu
ZY
D000970:Antineoplastic Agents / Q000737:chemistry*; D002119:Calcium Carbonate / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D010316:Particle Size
D000970:Antineoplastic Agents; D004337:Drug Carriers; D002119:Calcium Carbonate