title: Plastic membrane electrodes responsive to beta-blocker drugs.
abstract: The construction and performance characteristics of ion-selective PVC membrane electrodes for metoprolol, propranolol and timolol are described. The electrodes, based on ion-pair complexes with dinonylnaphthalenesulphonate or with tetra(2-chlorophenyl)borate show near-Nernstian responses down to 10(-5)M drug concentration. Their selectivity relative to various inorganic and organic cations is reported. Direct potentiometry is used to determine beta-blocker drugs both in aqueous solutions and pharmaceutical preparations, with good results.
authors.affiliation: Department of Chemistry, Shanghai Teacher's University, 10 Guilin Road, Shanghai, People's Republic of China.
authors.forename: Z R
authors.initials: ZR
authors.lastname: Zhang
authors.forename: D
authors.initials: D
authors.lastname: Yi Mao
authors.forename: Y X
authors.initials: YX
authors.lastname: Li
authors.forename: V V
authors.initials: VV
authors.lastname: Coşofreţ