[Native and chiral modified NMDA-receptor NR1-binding core ligands modeling].
Native and chiral modified (with non-enzymatic Asn racemization) NR1-binding core of NMDA-receptor was modelled by means of molecular dynamic ligand modelling. It was concluded that Gly, D-Ser, D-Asn and D-Thr are ligands of NR1-binding core native NMDA-receptor, whereas the chiral modified NR1-binding core is characterized by the aliphatic non-polar amino acids D-Ala, D-Leu, D-Ile and D-Pro as ligands. The latter amino acids can be considered as effective ligands of NMDA-receptor NR1-binding core in age-related pathology.
Korotina
A C
AC
Dmitriev
A V
AV
Tverdislov
V A
VA
D000818:Animals; D018846:Excitatory Amino Acids / Q000737:chemistry*; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D016194:Receptors, N-Methyl-D-Aspartate / Q000737:chemistry*
D018846:Excitatory Amino Acids; D008024:Ligands; C409466:NR1 NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate