Paraneoplastic Cushing syndrome because of corticotrophin-releasing hormone-secreting Wilms' tumor.
A 4-year-old boy with cushingoid appearance and a giant mass on his left kidney was referred to our department. Left nephroureterectomy was performed, and pathologic diagnosis was focal anaplastic nephroblastoma. Based on gradual decrease of postoperative weight, blood pressure, serum adrenocorticotropic hormone, and plasma cortisol levels, paraneoplastic Cushing syndrome because of Wilms' tumor was confirmed. Moreover, through immunohistochemical staining, we confirmed that the Wilms' tumor secreted corticotropin-releasing hormone and caused Cushing syndrome.
Wang
Jingfu
J
Department of Pediatric Oncology, Tianjin Cancer Hospital, Tianjin 300060, China. wangjingfu666@yahoo.com.cn
Zhang
Guangchao
G
D000182:ACTH Syndrome, Ectopic / Q000209:etiology*; D000324:Adrenocorticotropic Hormone / Q000032:analysis / Q000378:metabolism*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003480:Cushing Syndrome / Q000209:etiology*; D003609:Dactinomycin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007124:Immunoenzyme Techniques; D007680:Kidney Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism* / Q000532:radiotherapy / Q000601:surgery; D008297:Male; D009392:Nephrectomy; D012074:Remission Induction; D014057:Tomography, X-Ray Computed; D014750:Vincristine / Q000008:administration & dosage; D009396:Wilms Tumor / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism* / Q000532:radiotherapy / Q000601:surgery
D003609:Dactinomycin; D014750:Vincristine; D004317:Doxorubicin; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone