Direct catalytic asymmetric synthesis of cyclic aminals from aldehydes.
A highly enantioselective Brønsted acid catalyzed direct synthesis of cyclic aminals from aldehydes has been developed. The methodology has been applied to the first asymmetric synthesis of several antihypertensive aminal drugs including (R)-Thiabutazide.
Cheng
Xu
X
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1,D-45470, Mülheim an der Ruhr, Germany.
Vellalath
Sreekumar
S
Goddard
Richard
R
List
Benjamin
B
D000447:Aldehydes / Q000737:chemistry*; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D002851:Chromatography, High Pressure Liquid; D003500:Cyclization; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism; D062367:ortho-Aminobenzoates / Q000737:chemistry
D000447:Aldehydes; D000588:Amines; D062367:ortho-Aminobenzoates; C000219:anthranilamide