title: Meta-analysis of genome-wide linkage scans of attention deficit hyperactivity disorder.
abstract: Genetic contribution to the development of attention deficit hyperactivity disorder (ADHD) is well established. Seven independent genome-wide linkage scans have been performed to map loci that increase the risk for ADHD. Although significant linkage signals were identified in some of the studies, there has been limited replications between the various independent datasets. The current study gathered the results from all seven of the ADHD linkage scans and performed a Genome Scan Meta Analysis (GSMA) to identify the genomic region with most consistent linkage evidence across the studies. Genome-wide significant linkage (P(SR) = 0.00034, P(OR) = 0.04) was identified on chromosome 16 between 64 and 83 Mb. In addition there are nine other genomic regions from the GSMA showing nominal or suggestive evidence of linkage. All these linkage results may be informative and focus the search for novel ADHD susceptibility genes.
authors.affiliation: Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.
authors.forename: Kaixin
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authors.lastname: Zhou
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authors.lastname: Dempfle
authors.forename: Mauricio
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authors.lastname: Arcos-Burgos
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authors.lastname: Banaschewski
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authors.lastname: Biederman
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authors.lastname: Loo
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authors.lastname: Lopera
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authors.lastname: McCracken
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authors.forename: Maximilian
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authors.lastname: Muenke
authors.forename: Fernando
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authors.forename: Stanley F
authors.initials: SF
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authors.forename: T Trang
authors.initials: TT
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authors.forename: Robert D
authors.initials: RD
authors.lastname: Oades
authors.forename: Matthew N
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authors.lastname: Ogdie
authors.forename: Juan David
authors.initials: JD
authors.lastname: Palacio
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authors.lastname: Pineda
authors.forename: Andreas
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authors.lastname: Reif
authors.forename: Tobias J
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authors.lastname: Renner
authors.forename: Herbert
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authors.lastname: Roeyers
authors.forename: Marcel
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authors.lastname: Romanos
authors.forename: Aribert
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authors.lastname: Rothenberger
authors.forename: Helmut
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authors.lastname: Schäfer
authors.forename: Joseph
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authors.lastname: Sergeant
authors.forename: Richard J
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authors.forename: Susan L
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authors.lastname: Smalley
authors.forename: Edmund
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authors.lastname: Sonuga-Barke
authors.forename: Hans-Christoph
authors.initials: HC
authors.lastname: Steinhausen
authors.forename: Emma
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authors.lastname: van der Meulen
authors.forename: Susanne
authors.initials: S
authors.lastname: Walitza
authors.forename: Andreas
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authors.lastname: Warnke
authors.forename: Cathryn M
authors.initials: CM
authors.lastname: Lewis
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authors.lastname: Faraone
authors.forename: Philip
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authors.lastname: Asherson
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16; D008040:Genetic Linkage; D015894:Genome, Human; D006801:Humans; D008126:Lod Score; D011336:Probability; D044465:White People