Influence of interleukin 1alpha (IL-1alpha), IL-4, and IL-6 polymorphisms on genetic susceptibility to chronic osteomyelitis.
The association between cytokine gene polymorphisms and chronic osteomyelitis was investigated in order to determine whether genetic variability in cytokine genes predisposes to osteomyelitis susceptibility. Significant genotypic and allelic associations were observed between interleukin 1alpha (IL-1alpha) -889-C/T, IL-4 -1098-G/T and -590-C/T, and IL-6 -174-G/C polymorphisms and osteomyelitis in the Greek population, pointing towards their potential involvement in osteomyelitis pathogenesis.
Tsezou
Aspasia
A
University of Thessalia, Medical School, Department of Biology, Mezourlo 41 222 Larissa, Greece. atsezou@med.uth.gr
Poultsides
Lazaros
L
Kostopoulou
Fotini
F
Zintzaras
Elias
E
Satra
Maria
M
Kitsiou-Tzeli
Sofia
S
Malizos
Konstantinos N
KN
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002908:Chronic Disease; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006115:Greece; D006801:Humans; D053582:Interleukin-1alpha / Q000235:genetics*; D015847:Interleukin-4 / Q000235:genetics*; D015850:Interleukin-6 / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
D053582:Interleukin-1alpha; D015850:Interleukin-6; D015847:Interleukin-4