title: Petabyte-scale innovations at the European Nucleotide Archive.
abstract: Dramatic increases in the throughput of nucleotide sequencing machines, and the promise of ever greater performance, have thrust bioinformatics into the era of petabyte-scale data sets. Sequence repositories, which provide the feed for these data sets into the worldwide computational infrastructure, are challenged by the impact of these data volumes. The European Nucleotide Archive (ENA; http://www.ebi.ac.uk/embl), comprising the EMBL Nucleotide Sequence Database and the Ensembl Trace Archive, has identified challenges in the storage, movement, analysis, interpretation and visualization of petabyte-scale data sets. We present here our new repository for next generation sequence data, a brief summary of contents of the ENA and provide details of major developments to submission pipelines, high-throughput rule-based validation infrastructure and data integration approaches.
authors.affiliation: EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK. cochrane@ebi.ac.uk
authors.forename: Guy
authors.initials: G
authors.lastname: Cochrane
authors.forename: Ruth
authors.initials: R
authors.lastname: Akhtar
authors.forename: James
authors.initials: J
authors.lastname: Bonfield
authors.forename: Lawrence
authors.initials: L
authors.lastname: Bower
authors.forename: Fehmi
authors.initials: F
authors.lastname: Demiralp
authors.forename: Nadeem
authors.initials: N
authors.lastname: Faruque
authors.forename: Richard
authors.initials: R
authors.lastname: Gibson
authors.forename: Gemma
authors.initials: G
authors.lastname: Hoad
authors.forename: Tim
authors.initials: T
authors.lastname: Hubbard
authors.forename: Christopher
authors.initials: C
authors.lastname: Hunter
authors.forename: Mikyung
authors.initials: M
authors.lastname: Jang
authors.forename: Szilveszter
authors.initials: S
authors.lastname: Juhos
authors.forename: Rasko
authors.initials: R
authors.lastname: Leinonen
authors.forename: Steven
authors.initials: S
authors.lastname: Leonard
authors.forename: Quan
authors.initials: Q
authors.lastname: Lin
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Lopez
authors.forename: Dariusz
authors.initials: D
authors.lastname: Lorenc
authors.forename: Hamish
authors.initials: H
authors.lastname: McWilliam
authors.forename: Gaurab
authors.initials: G
authors.lastname: Mukherjee
authors.forename: Sheila
authors.initials: S
authors.lastname: Plaister
authors.forename: Rajesh
authors.initials: R
authors.lastname: Radhakrishnan
authors.forename: Stephen
authors.initials: S
authors.lastname: Robinson
authors.forename: Siamak
authors.initials: S
authors.lastname: Sobhany
authors.forename: Petra Ten
authors.initials: PT
authors.lastname: Hoopen
authors.forename: Robert
authors.initials: R
authors.lastname: Vaughan
authors.forename: Vadim
authors.initials: V
authors.lastname: Zalunin
authors.forename: Ewan
authors.initials: E
authors.lastname: Birney
mesh_terms: D030561:Databases, Nucleic Acid; D020407:Internet; D017421:Sequence Analysis / Q000639:trends*; D018511:Systems Integration