[Left ventricular diastolic dysfunction. Implications for anesthesia and critical care].
Over the last two decades there has been a growing recognition that cardiac function is not solely determined by systolic but also essentially by diastolic function. Left ventricular diastolic dysfunction is characterized by an impairment of ventricular filling caused either by abnormal relaxation, an active energy consuming process or decreased compliance, which is determined by passive tissue properties of the ventricle. Doppler echocardiography, including tissue Doppler imaging, has emerged as the preferred clinical tool for the assessment of left ventricular diastolic function. Recently the importance of left ventricular diastolic function is increasingly being recognized also during the perioperative period. Newer studies have shown that after cardiopulmonary bypass there is a significant decrease in left ventricular compliance. Experimental studies have demonstrated that sepsis is associated with a decrease in both active relaxation and ventricular compliance. Initial studies are also focusing on therapeutic options for patients with isolated diastolic dysfunction.
Meierhenrich
R
R
Klinik für Anästhesiologie, Universitätsklinikum Ulm, Steinhövelstr. 9, 89075 Ulm, Deutschland. rainer.meierhenrich@uniklinik-ulm.de
Schütz
W
W
Gauss
A
A
D000758:Anesthesia; D006328:Cardiac Catheterization; D003422:Critical Care; D003971:Diastole / Q000502:physiology; D054144:Heart Failure, Diastolic / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008943:Mitral Valve / Q000502:physiology; D011664:Pulmonary Valve / Q000502:physiology; D014463:Ultrasonography; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology; D016277:Ventricular Function, Left / Q000502:physiology