title: Electrochemical oxidation of methylenedioxyamphetamines.
abstract: Four amphetamine derivatives bearing a methylenedioxy group at positions 3 and 4 of the benzene ring and differing in their substitution at C(6) were studied by differential pulse voltammetry in aqueous media. These experiments showed a single oxidation peak for the C(6)-H, -Br and -Cl compounds, while the C(6)-NO(2) analogue was not oxidized. The oxidation peak is interpreted as due to the removal of one electron from the aromatic electrophore with formation of a radical cation stabilized by the dioxole ring. The linear relationship between the peak current and the concentration of the derivatives is appropriate for development of a quantitative method for their determination. pK' values were determined using both electrochemical and spectrophotometric methods.
authors.affiliation: Electrochemistry Laboratory, University of Chile, Santiago, Chile.
authors.forename: J A
authors.initials: JA
authors.lastname: Squella
authors.forename: B K
authors.initials: BK
authors.lastname: Cassels
authors.forename: M
authors.initials: M
authors.lastname: Arata
authors.forename: M P
authors.initials: MP
authors.lastname: Bavestrello
authors.forename: L J
authors.initials: LJ
authors.lastname: Nuñez-Vergara