[Peculiarities of tricarboxylic acid cycle in the myocardium of adult and old rats in the case of immobilization stress].
Indices showing Krebs cycle functioning in the hearts of adult and old rats subjected to 30-minutes immobilization were studied in order to find out the causes of age-related increase of heart sensitivity to stress. The studies have shown that compensatory changes of energy metabolism promoting limitation of stress-induced decrease of energy supply of the heart muscle took place in the myocardium mitochondria in adult and old rats during immobilization stress. The changes are associated with maintenance of high rate of redox reactions in the Krebs cycle and increase of myocardium respiration in old rats, and with an increase of the FAD-dependent processes in tissue respiration in adult rats.
Shvets
V N
VN
Davydov
V V
VV
D000222:Adaptation, Physiological; D000375:Aging / Q000378:metabolism*; D000818:Animals; D002952:Citric Acid Cycle; D008297:Male; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000378:metabolism*