Rafts, anchors and viruses--a role for glycosylphosphatidylinositol anchored proteins in the modification of enveloped viruses and viral vectors.
Lipid rafts have been proposed as sites for the assembly of a number of viruses and are considered to play a major role in pseudotyping events. As a consequence, host glycosylphosphatidylinositol (GPI) anchored proteins commonly associated with lipid rafts can be found being incorporated into viral lipid envelopes with beneficial consequences for viral replication. In this review we will look at the link between lipid rafts, GPI-anchored proteins and retroviral particles and how these relationships can be exploited for the modification of enveloped viruses.
Metzner
Christoph
C
Institute of Virology, Department of Pathobiology, University of Veterinary Medicine, Veterinärplatz 1, 1210 Vienna, Austria. christoph.metzner@vu-wien.ac.at
Salmons
Brian
B
Günzburg
Walter H
WH
Dangerfield
John A
JA
D000818:Animals; D002460:Cell Line; D005822:Genetic Vectors; D017261:Glycosylphosphatidylinositols / Q000378:metabolism*; D006801:Humans; D021962:Membrane Microdomains / Q000378:metabolism* / Q000821:virology*; D008954:Models, Biological; D015202:Protein Engineering; D012190:Retroviridae / Q000235:genetics / Q000502:physiology*; D014162:Transfection; D019065:Virus Assembly / Q000502:physiology*
D017261:Glycosylphosphatidylinositols