Antimicrobial drug-selection markers for Burkholderia pseudomallei and B. mallei.
Genetic research into the select agents Burkholderia pseudomallei and B. mallei is currently hampered by a paucity of approved antimicrobial drug-selection markers. The strict regulations imposed on researchers in the United States but not in other parts of the world lead to discrepancies in practice, hinder distribution of genetically modified strains, and impede progress in the field. Deliberation and decisions regarding alternative selection markers (antimicrobial and nonantimicrobial drugs) by the international community, regulatory authorities, and funding agencies are needed.
Schweizer
Herbert P
HP
Rocky Mountain Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA. herbert.schweizer@colostate.edu
Peacock
Sharon J
SJ
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D042726:Burkholderia mallei / Q000187:drug effects* / Q000235:genetics; D016957:Burkholderia pseudomallei / Q000187:drug effects* / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D005819:Genetic Markers; D006801:Humans; D008826:Microbial Sensitivity Tests; D012641:Selection, Genetic
D000900:Anti-Bacterial Agents; D005819:Genetic Markers