title: Genetic variants in the renin-angiotensin system genes are associated with cardiovascular-renal-related risk factors in Mexican Americans.
abstract: The aim of this study is to examine whether the ACE-I/D, AGT-M235T, and AT1R-A1166C polymorphisms of the renin-angiotensin system (RAS) genes are associated with cardiovascular and renal-related risk factors in Mexican Americans. Study participants (N = 848) were genotyped by Taqman assays. Association analyses were performed by measured genotype approach. Of the phenotypes examined, the ACE-I/D, AGT-M235T, and AT1R-A1166C polymorphisms exhibited significant association with systolic blood pressure, glomerular filtration rate and body mass index, respectively. The data suggest that the polymorphisms examined in the RAS may modulate the risk factors associated with cardiovascular-renal disease.
authors.affiliation: Division of Nephrology, Department of Medicine, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA. thameem@uthscsa.edu
authors.forename: Farook
authors.initials: F
authors.lastname: Thameem
authors.forename: V Saroja
authors.initials: VS
authors.lastname: Voruganti
authors.forename: Xin
authors.initials: X
authors.lastname: He
authors.forename: Subrata D
authors.initials: SD
authors.lastname: Nath
authors.forename: John
authors.initials: J
authors.lastname: Blangero
authors.forename: Jean W
authors.initials: JW
authors.lastname: MacCluer
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Comuzzie
authors.forename: Hanna E
authors.initials: HE
authors.lastname: Abboud
authors.forename: Nedal H
authors.initials: NH
authors.lastname: Arar
mesh_terms: D000419:Albuminuria / Q000235:genetics; D000483:Alleles; D000808:Angiotensinogen / Q000235:genetics; D002318:Cardiovascular Diseases / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics; D054643:INDEL Mutation; D007674:Kidney Diseases / Q000235:genetics*; D008297:Male; D017058:Mexican Americans / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics; D012084:Renin-Angiotensin System / Q000235:genetics*; D012307:Risk Factors; D013781:Texas
chemical_list: D044140:Receptor, Angiotensin, Type 1; D000808:Angiotensinogen; C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A