title: Discordance in spirometric interpretations using three commonly used reference equations vs national health and nutrition examination study III.
abstract: BACKGROUND
  Spirometry plays an essential role in the diagnosis and management of pulmonary diseases. The accurate interpretation of spirometric data depends on comparison to a reference population to identify abnormalities in ventilatory function. National guidelines recommended the use of the National Health and Nutrition Examination Study (NHANES) III data set as the preferred reference population for those persons 8 to 80 years of age in the United States.
  
  
  OBJECTIVE
  To determine the effect of using NHANES III reference equations, compared to those of Crapo et al (Crapo), Knudson et al (Knudson), or Morris et al (Morris), on spirometric interpretations in non-Hispanic white patients.
  
  
  METHODS
  We conducted a cross-sectional study of all white patients undergoing spirometry testing at our hospital from January 2000 through May 2007. Patients were classified as normal, restricted, obstructed, or mixed, based on the American Thoracic Society (ATS)/European Respiratory Society (ERS) guidelines, using the Crapo, Knudson, Morris, and NHANES III prediction equations. Differences in the classifications based on the reference data set were evaluated.
  
  
  RESULTS
  At total of 8,733 subjects (62.4% male subjects) were identified, with a mean age of 53 years. Discordance was most common when the results from prediction equations by Knudson and Morris were compared to those of NHANES III (45.5% and 35.3%, respectively). Diagnostic recategorizations occurred less frequently when the prediction equations by Crapo were compared with those of NHANES III (15.9%). Relative to NHANES III, the prediction equations by Knudson, Crapo, and Morris tend to overclassify obstruction and underclassify restriction.
  
  
  CONCLUSIONS
  There is significant discordance between the prediction equations put forth by Crapo, Knudson, Morris, and the NHANES III. Our data suggest that the diagnostic reclassification of many patients undergoing pulmonary function testing will occur when ATS/ERS guidelines are implemented. Pulmonologists and other physicians interpreting spirometry need to be aware of the presence and nature of these changes.
authors.affiliation: Departments of Internal Medicine, Walter Reed Army Medical Center, Washington, DC.
authors.forename: Jacob
authors.initials: J
authors.lastname: Collen
authors.affiliation: Departments of Internal Medicine, Walter Reed Army Medical Center, Washington, DC.
authors.forename: David
authors.initials: D
authors.lastname: Greenburg
authors.affiliation: Pulmonary/Critical Care Medicine, Walter Reed Army Medical Center, Washington, DC.
authors.forename: Aaron
authors.initials: A
authors.lastname: Holley
authors.affiliation: Pulmonary/Critical Care Medicine, Walter Reed Army Medical Center, Washington, DC. Electronic address: christopher.king@na.amedd.army.mil.
authors.forename: Christopher S
authors.initials: CS
authors.lastname: King
authors.affiliation: Pulmonary/Critical Care Medicine, Walter Reed Army Medical Center, Washington, DC.
authors.forename: Oleh
authors.initials: O
authors.lastname: Hnatiuk
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D017408:Guidelines as Topic; D006306:Health Surveys; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys; D011237:Predictive Value of Tests; D012372:ROC Curve; D012015:Reference Standards; D012016:Reference Values; D012189:Retrospective Studies; D017678:Sex Distribution; D012955:Societies, Medical; D013147:Spirometry / Q000592:standards*; D055815:Young Adult