Guanylyl cyclase sees the light.
Cyclic guanosine monophosphate (cGMP) is a critical second messenger that regulates cardiovascular function and vision in humans. Two recent papers, including one in BMC Structural Biology, have revealed atomic structures of the enzymes that catalyze the synthesis of cGMP providing new clues about the molecular basis of substrate specificity and allosteric regulation in nucleotide cyclases.
Tesmer
John J G
JJ
Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109-2216, USA. johntesmer@umich.edu
D000494:Allosteric Regulation; D000818:Animals; D006152:Cyclic GMP / Q000378:metabolism*; D006162:Guanylate Cyclase / Q000737:chemistry* / Q000502:physiology*; D006801:Humans; D008968:Molecular Conformation; D015398:Signal Transduction / Q000502:physiology*; D013379:Substrate Specificity
D006162:Guanylate Cyclase; D006152:Cyclic GMP