title: Cardiac surgery and sickle cell disease.
abstract: Three patients with homozygous sickle cell disease underwent successful open heart surgery for multivalvular lesions. Details of the surgical technique and the necessary precautions are described. Exchange transfusion was implemented in all cases. Crucial issues in cardiac surgical management to avoid or at least minimize vasoocclusive crisis and associated complications are discussed.
authors.affiliation: Department of Surgery, Faculty of Medicine, King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Khaled_alebrahim@yahoo.com
authors.forename: Khaled E
authors.initials: KE
authors.lastname: Al-Ebrahim
mesh_terms: D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000601:surgery; D000925:Anticoagulants / Q000627:therapeutic use; D001803:Blood Transfusion; D002315:Cardiopulmonary Bypass; D005260:Female; D006324:Heart Arrest, Induced; D006349:Heart Valve Diseases / Q000150:complications / Q000601:surgery*; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects / Q000295:instrumentation; D006440:Hemofiltration; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000209:etiology / Q000517:prevention & control; D011474:Prosthesis Design; D012214:Rheumatic Heart Disease / Q000150:complications / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants