[Not Available].
Oxidation of 6-methoxyquinoline with vanadate shows the possibility of initial complex formation between the dioxovanadium(V) ion VO(+)(2) and the ethereal oxygen atom. The opening of the homocycle yields mainly 2-pyridone-3-carboxylic acid. In the case of quinine or mefloquine, the VO(+)(2) ion preferentially forms a pentagonal chelate with the secondary alcohol function. Oxidation of this complex initially produces quinoline-4-carboxylic acids. The acid that results from mefloquine is stable in the reaction solution and this property allows a reproducible consumption of reagent and a quantitative determination of this new antimalarial drug.
Assamoi
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Laboratoire de Chimie Analytique, Faculté des Sciences Pharmaceutiques et Biologiques, 3, rue J. B. Clément, F 92 290 Chatenay Malabry, France.
Hamon
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Chastagnier
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Chaigneau
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