Synthesis of 6H-indolo[2,3-b]quinoxaline-N-glycosides and their cytotoxic activity against human ceratinocytes (HaCaT).
N-glycosides of 6H-indolo[2,3-b]quinoxalines were prepared and structurally characterized. The synthesis relies on the cyclocondensation of isatine-N-glycosides with 1,2-diaminobenzenes. Some products exhibit weak cytotoxic activity against human ceratinocytes (HaCaT).
Driller
Katrin Marie
KM
Institut für Chemie, Universität Rostock, Albert-Einstein-Str. 3a, 18059 Rostock, Germany.
Libnow
Stefanie
S
Hein
Martin
M
Harms
Manuela
M
Wende
Kristian
K
Lalk
Michael
M
Michalik
Dirk
D
Reinke
Helmut
H
Langer
Peter
P
D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D015603:Keratinocytes / Q000187:drug effects*; D011810:Quinoxalines / Q000737:chemistry*
D006027:Glycosides; D007211:Indoles; D011810:Quinoxalines; C030374:indole