CD40-CD40 ligand interactions in oxidative stress, inflammation and vascular disease.
CD40 ligand (CD40L) and its receptor CD40 participate in numerous inflammatory pathways that contribute to multiple pathophysiological processes. A role for CD40-CD40L interactions has been identified in atherosclerosis, and such interactions are known to destabilize atherosclerotic plaques by inducing the expression of cytokines, chemokines, growth factors, matrix metalloproteinases and pro-coagulant factors. The CD40-CD40L interaction has also been implicated in immune system disorders. Recent studies have suggested that CD40-CD40L interactions regulate oxidative stress and affect various signaling pathways in both the immunological and cardiovascular systems. Here, we discuss the emerging role of CD40-CD40L-mediated processes in oxidative stress, inflammatory pathways and vascular diseases. Understanding the roles and regulation of CD40-CD40L-mediated oxidative signaling in immune and non-immune cells could facilitate the development of therapeutics targeting diverse inflammatory diseases.
Rizvi
Muhammad
M
Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
Pathak
Didi
D
Freedman
Jane E
JE
Chakrabarti
Subrata
S
D050197:Atherosclerosis / Q000209:etiology / Q000503:physiopathology; D019013:CD40 Antigens / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D023201:CD40 Ligand / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D048909:Diabetes Complications / Q000503:physiopathology; D006801:Humans; D053306:Hyper-IgM Immunodeficiency Syndrome / Q000209:etiology / Q000503:physiopathology; D007249:Inflammation / Q000209:etiology / Q000276:immunology / Q000503:physiopathology*; D008954:Models, Biological; D009154:Mutation; D018384:Oxidative Stress; D013927:Thrombosis / Q000209:etiology / Q000503:physiopathology; D014652:Vascular Diseases / Q000209:etiology / Q000276:immunology / Q000503:physiopathology*
D019013:CD40 Antigens; D023201:CD40 Ligand