title: Celiac artery thrombosis in a young patient with multiple platelet receptor polymorphisms and local compression syndrome.
abstract: Numerous clinical and experimental studies have been published concerning platelet receptor polymorphism and their role in causing myocardial infarction at an earlier age. It is still unclear, however, whether these polymorphisms are a risk factor for other occlusive diseases such as those in visceral arteries. We report a case of a young woman with acute celiac artery thrombosis and multiple platelet receptor polymorphisms. In addition, the intraoperative exploration showed some evidence of a local vascular compression syndrome. The patient was successfully treated with a bypass procedure and combined anticoagulation. It seems that platelet receptor polymorphisms are a moderate risk factor for local artery thrombosis regardless of vascular region. The obligatory precondition is pre-existing vascular damage, such as that caused by a local compression syndrome.
authors.affiliation: Department of Vascular Surgery and Kidney Transplantation, University Hospital Düsseldorf, Düsseldorf, Germany. dr.j.rudolph@t-online.de
authors.forename: Jens
authors.initials: J
authors.lastname: Rudolph
authors.forename: Siamak
authors.initials: S
authors.lastname: Pourhassan
authors.forename: Fuat
authors.initials: F
authors.lastname: Saner
authors.forename: Rainer B
authors.initials: RB
authors.lastname: Zotz
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Sandmann
mesh_terms: D000208:Acute Disease; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D001157:Arterial Occlusive Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000235:genetics / Q000628:therapy; D002445:Celiac Artery / Q000000981:diagnostic imaging / Q000601:surgery; D019299:Decompression, Surgical; D005260:Female; D006801:Humans; D038982:Integrin alpha2beta1 / Q000235:genetics*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D013577:Syndrome; D017131:Thrombectomy; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000235:genetics / Q000628:therapy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014652:Vascular Diseases / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery
chemical_list: D000925:Anticoagulants; D038982:Integrin alpha2beta1; D019039:Platelet Glycoprotein GPIIb-IIIa Complex