Hyperglycemia may alter cytokine production and phagocytosis by means other than hyperosmotic stress.
In the previous issue of Critical Care, Otto and colleagues used in vitro studies to explore the theory that immunomodulation, by correction of hyperglycemia, may be a contributing factor to the reported efficacy of intensive insulin therapy (IIT) in critically ill patients. They suggested that hyperglycemia via hyperosmolarity at supra-physiological levels potentiates the production of cytokines by peripheral blood mononuclear cells in response to lipopolysaccharide (LPS) stimulation and that it also reduces the responses of phagocytosis and oxidative burst in human granulocytes. The efficacy of IIT, they concluded, may be partially due to the correction of hyperosmolality. Other studies, however, have suggested that immunological responses to LPS in the presence of hyperglycemia are mediated by a mechanism other than hyperosmolality.
Wade
Charles E
CE
US Army Institute for Surgical Research, 3400 Rawley E. Chambers Avenue, Fort Sam Houston, TX 78234, USA. charles.wade@amedd.army.mil
D016207:Cytokines / Q000096:biosynthesis*; D006098:Granulocytes / Q000473:pathology; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000473:pathology* / Q000503:physiopathology*; D009994:Osmolar Concentration; D009997:Osmotic Pressure / Q000502:physiology; D010587:Phagocytosis / Q000502:physiology*
D016207:Cytokines