Orthogonal or simultaneous use of disulfide and hydrazone exchange in dynamic covalent chemistry in aqueous solution.
Hydrazone and disulfide exchange have been combined in a single system, but can be addressed independently: by adjusting the pH of the solution from acidic to mildly basic it is possible to switch from exclusively hydrazone exchange to exclusively disulfide exchange, while at intermediate pH both reactions occur simultaneously.
Rodriguez-Docampo
Zaida
Z
Department of Chemistry, University of Chemistry, Lensfield Road, Cambridge, UK.
Otto
Sijbren
S