title: Synthesis and activity of a potent alpha-glucosidase inhibitor, (1R, 6R, 8S)-cis-1,6-dihydroxypyrrolizidine, and its isomer.
abstract: The synthesis ofcis- and trans-1,6-dihydroxypyrrolizidine starting fromtrans-4-hydroxyl-L-proline and their evaluation as glycosidase inhibitors are reported. Thecis-isomer was found to be a potent inhibitor against alpha-glucosidase and showed weak inhibitory effect against other glycosidases. Thetrans-isomer exhibited weak inhibitions of b-glucosidase and amyloglucosidase and poor inhibition of other glycosidases.
authors.affiliation: Korea Institute of Science and Technology, 39-1 Hawalgog-Dong, Sungbuk-Gu, 136-791, Seoul, Korea.
authors.forename: K E
authors.initials: KE
authors.lastname: Jung
authors.forename: Y K
authors.initials: YK
authors.lastname: Kang
authors.forename: D J
authors.initials: DJ
authors.lastname: Kim
authors.forename: S W
authors.initials: SW
authors.lastname: Park