title: Intractable Prinzmetal's angina three months after implantation of sirolimus-eluting stent.
abstract: Sirolimus-eluting stents (SES) prevent neointimal proliferation and have been widely used to treat stenotic lesions in coronary arteries because of a significant reduction of restenosis in comparison with bare-metal stents. Sirolimus, however, may cause endothelial dysfunction by damage to vascular endothelium or impairing vascular repair. Recent studies report the occurrence of exercise- or acetylcholine-induced coronary vasoconstriction in the vessel segments adjacent to the SES. We report here a clinical case of intractable Prinzmetal's angina 3 months after SES implantation and recommend extended, thorough follow up of patients who have undergone SES implantation.
authors.affiliation: Division of Cardiology, National Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka, 565-8565, Japan. mitsuru@ hsp.ncvc.go.jp
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Abe
authors.forename: Akemi
authors.initials: A
authors.lastname: Yoshida
authors.forename: Yoritaka
authors.initials: Y
authors.lastname: Otsuka
mesh_terms: D000328:Adult; D000788:Angina Pectoris, Variant / Q000209:etiology*; D054855:Drug-Eluting Stents / Q000009:adverse effects*; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D020123:Sirolimus / Q000008:administration & dosage / Q000009:adverse effects*; D013997:Time Factors
chemical_list: D007166:Immunosuppressive Agents; D020123:Sirolimus