title: Influence of chemotherapy courses on the rate of bloodstream infections during neutropenia in adult acute myeloid leukaemia.
abstract: To evaluate the effect of various chemotherapy courses on the rate of bloodstream infections (BSI) during therapy-related neutropenia, all infection episodes of adult patients with acute myeloid leukaemia (AML) during 7 y were retrospectively analysed in a university hospital. Of the 182 infection episodes in 76 AML patients, 37% (n = 68) were BSI. The riskratio (RR) of BSI was highest after regimens containing high-dose cytarabine (2.4 with 95% confidence interval (CI) 1.3-4.4) and lowest after thioguanine-containing courses (RR: 0.2, 95% CI 0.2-0.5). Chemotherapy courses per se may have an influence on the rate of BSI during neutropenia.
authors.affiliation: Department of Internal Medicine, Lapland Central Hospital, Rovaniemi, Finland. urpo.kinnunen@oulu.fi
authors.forename: Urpo
authors.initials: U
authors.lastname: Kinnunen
authors.forename: Pirjo
authors.initials: P
authors.lastname: Koistinen
authors.forename: Pasi
authors.initials: P
authors.lastname: Ohtonen
authors.forename: Markku
authors.initials: M
authors.lastname: Koskela
authors.forename: Hannu
authors.initials: H
authors.lastname: Syrjälä
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D016470:Bacteremia / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D005434:Flow Cytometry; D016469:Fungemia / Q000453:epidemiology / Q000209:etiology; D006090:Gram-Negative Bacteria / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000302:isolation & purification; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced*; D018709:Statistics, Nonparametric; D015003:Yeasts / Q000302:isolation & purification; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents