title: The distribution of HBV genotypes and clinical significance in familial clustering in an infected population with unfavorable prognosis.
abstract: Using a nested-PCR genotyping system, we analyzed the viral genotypes in HBV-infected patients from HBV clustering infection families (CIFs), as compared with HBV infected patients without familial infection history. The patients in the CIF group showed significantly increased prevalence of genotype C infection, while genotype B was absent. Additionally, in the genotype C carriers younger than 50 years old, the prevalence of HCC and LC were significantly increased in CIF compared to the control. We found that HBeAg-positive HBV genotype C carriers are prone to develop end-stage liver diseases earlier than those infected by genotype B.
authors.affiliation: Department of Infectious Diseases, The First Affiliated Hospital of Xi'an JiaoTong University School of Medicine, 710061, Xi'an, Shaanxi Province, China. sourmilk2003@163.com
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Liu
authors.forename: Yongqin
authors.initials: Y
authors.lastname: Li
authors.forename: Tianyan
authors.initials: T
authors.lastname: Chen
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yang
authors.forename: Ke
authors.initials: K
authors.lastname: Wang
authors.forename: Yingli
authors.initials: Y
authors.lastname: He
authors.forename: Qian
authors.initials: Q
authors.lastname: Yang
authors.forename: Feng
authors.initials: F
authors.lastname: Ye
authors.forename: Yan
authors.initials: Y
authors.lastname: Jin
authors.forename: Ting
authors.initials: T
authors.lastname: Qiu
authors.forename: Shumei
authors.initials: S
authors.lastname: Lin
authors.forename: Min
authors.initials: M
authors.lastname: Liu
authors.forename: Yingren
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002353:Carrier State / Q000821:virology; D002648:Child; D002675:Child, Preschool; D002681:China; D005192:Family Health; D005260:Female; D005838:Genotype; D006513:Hepatitis B e Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000235:genetics* / Q000302:isolation & purification; D019694:Hepatitis B, Chronic / Q000175:diagnosis* / Q000821:virology; D006801:Humans; D008107:Liver Diseases / Q000175:diagnosis / Q000821:virology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D055815:Young Adult
chemical_list: D006513:Hepatitis B e Antigens