An efficient synthesis of 3-(E)-hydroxypropenyl cephem derivatives, key intermediates for 3-(E)-ammoniopropenylcephalosporin antibiotics.
An efficient synthesis of 3-(E)-hydroxy- and 3-(E)-acetoxypropenylcephem derivatives, key intermediates for the synthesis of 3-(E)-propenylcephalosporins was achievedvia Stille coupling reaction of 3-trifloxycephem with 3-(E)-tributylstannylallylic alcohol.
Lee
Y S
YS
Division of Applied Science, Korea Institute of Science & Technology, Cheongryang, P.O. Box 131, 130-650, Seoul, Korea.
Lee
J Y
JY
Jeong
J H
JH
Park
H
H