title: Effect of bone morphogenetic protein signaling on development of the jaw skeleton.
abstract: Bone morphogenetic proteins (BMPs) regulate many aspects of development including skeletogenesis. Here, we examined the response of neural crest-derived cells to ectopic BMP signaling by infecting avian embryos with retroviruses encoding Bmp-2 or Bmp-4 at various times of development. Infection at stages 10 and 15 transformed large areas of the skull into cartilage by day 13. At this time cartilage condensations were still forming, which revealed the presence of uncommitted mesenchymal cells. By day 19, hypertrophic chondrocytes were present in the cartilage possibly due to changes in the perichondrium that relieved repression on hypertrophy. While these cells expressed Sox9, Collagen-2, Runx2, Ihh, Noggin, and Collagen-10, cartilage was not replaced by bone. Whether this is an intrinsic property of the skull cartilage, or results from sustained Bmp signaling is not known.
authors.affiliation: Department of Orthopaedic Surgery, University of California at San Francisco, San Francisco, California 04110, USA.
authors.forename: Diane
authors.initials: D
authors.lastname: Hu
authors.forename: Celine
authors.initials: C
authors.lastname: Colnot
authors.forename: Ralph S
authors.initials: RS
authors.lastname: Marcucio
mesh_terms: D000818:Animals; D052004:Bone Morphogenetic Protein Receptors / Q000235:genetics / Q000378:metabolism; D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000378:metabolism*; D002356:Cartilage / Q000196:embryology / Q000378:metabolism; D002454:Cell Differentiation; D049109:Cell Proliferation; D002642:Chick Embryo; D020219:Chondrogenesis; D007568:Jaw / Q000166:cytology / Q000196:embryology* / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D019485:Bone Morphogenetic Proteins; D052004:Bone Morphogenetic Protein Receptors