[Study on optimization of the hydrolysis process of dioscin catalyzed by hydrochloric acid].
OBJECTIVE
To study the optimization of hydrolysis process of dioscin catalyzed by hydrochloric acid.


METHODS
The effects of hydrochloric acid concentration, reaction temperature, reaction time and their interactions had been investigated using orthogonal design and single-factor experiments.


RESULTS
The optimum hydrolysis conditions were as follows: reaction temperature 90 degrees C, reaction time 3h, hydrochloric acid concentration 2.0 mol/L.


CONCLUSIONS
Hydrochloric acid concentration and reaction temperature should be controlled because of their remarkable influence on hydrolysis process.
Li
Qian
Q
Institute of Fine Chemistry and Engineering, Kaifeng 475001, China. liq@henu.edu.cn
Gao
Xiang-Tao
XT
Zhao
Wen-Lei
WL
Liu
Xiu-Hua
XH
D000704:Analysis of Variance; D002384:Catalysis; D027742:Dioscorea / Q000737:chemistry*; D004144:Diosgenin / Q000302:isolation & purification*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification*; D006851:Hydrochloric Acid / Q000737:chemistry*; D006868:Hydrolysis; D027343:Rhizome / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*; D013696:Temperature; D013997:Time Factors
D004365:Drugs, Chinese Herbal; D004144:Diosgenin; D006851:Hydrochloric Acid