Serum uric acid levels correlate with left atrial function and systolic right ventricular function in patients with newly diagnosed heart failure: the hellenic heart failure study.
The authors sought to investigate whether serum uric acid levels are associated with systolic left and right ventricular function, as well as left atrial function in patients with newly diagnosed heart failure. The authors enrolled 106 consecutive patients (mean age 65+/-13 years). Echocardiographic and biochemical assessment was performed during the third day of hospitalization. Pulsed tissue Doppler imaging of the systolic function of mitral and tricuspid annulus was characterized by the systolic waves (Smv and Stv, respectively), expressed in cm/s, and the left atrial function by the Amv wave. Left atrial kinetics was calculated using an equation. Serum uric acid levels were inversely correlated with Stv (P=.005) and left atrial kinetics (P=.05), after controlling for potential confounders. Uric acid levels appear to be correlated with more impaired right ventricular systolic function and decreased left atrial work in patients with heart failure.
Chrysohoou
Christina
C
First Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece. chrysohoou@usa.net
Pitsavos
Christos
C
Barbetseas
John
J
Brili
Stella
S
Kotroyiannis
Iason
I
Papademetriou
Labros
L
Metallinos
George
G
Skoumas
John
J
Tentolouris
Costas
C
Stefanadis
Christodoulos
C
D000368:Aged; D018450:Disease Progression; D005260:Female; D006305:Health Status Indicators; D006325:Heart Atria / Q000000981:diagnostic imaging*; D054144:Heart Failure, Diastolic / Q000000981:diagnostic imaging / Q000503:physiopathology*; D054143:Heart Failure, Systolic / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008875:Middle Aged; D010865:Pilot Projects; D011379:Prognosis; D011446:Prospective Studies; D013599:Systole; D014463:Ultrasonography; D014527:Uric Acid / Q000097:blood*; D016278:Ventricular Function, Right
D014527:Uric Acid