title: [Massive hemorrhage following photodynamic therapy in exudative ARMD].
abstract: Photodynamic therapy (PDT) can prevent visual loss and the risk of hemorrhage in exudative ARMD. Nevertheless, it can sometimes complicate with massive hemorrhage. We report the case of a massive macular hemorrhage 4 days after a first treatment with dynamic phototherapy (PDT) with Visudyne for rapidly progressive (6 months) exudative AMD with occult neovessels in an 86-year-old female. The rationale for PDT was a rapidly progressive lesion with preserved visual acuity (20/40). Four days after injection, a massive submacular hemorrhage of 6 disc diameter developed, with a dramatic decrease in visual acuity. This hemorrhage recovered within 6 months, producing large, fibroglial, submacular scarring with changes on the retinal pigment epithelium. This case highlights the possible side effects of this treatment.
authors.affiliation: Service d'ophtalmologie, CHU Dupuytren, Limoges, France.
authors.forename: L
authors.initials: L
authors.lastname: Hartmann
authors.forename: J-P
authors.initials: JP
authors.lastname: Adenis
authors.forename: P-Y
authors.initials: PY
authors.lastname: Robert
mesh_terms: D000369:Aged, 80 and over; D020256:Choroidal Neovascularization / Q000188:drug therapy / Q000209:etiology; D002921:Cicatrix / Q000209:etiology / Q000473:pathology; D018450:Disease Progression; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008268:Macular Degeneration / Q000150:complications / Q000188:drug therapy*; D010778:Photochemotherapy / Q000009:adverse effects*; D017319:Photosensitizing Agents / Q000009:adverse effects* / Q000627:therapeutic use; D011166:Porphyrins / Q000009:adverse effects* / Q000627:therapeutic use; D012166:Retinal Hemorrhage / Q000209:etiology*; D055213:Retinal Pigment Epithelium / Q000473:pathology; D000077362:Verteporfin; D014792:Visual Acuity
chemical_list: D017319:Photosensitizing Agents; D011166:Porphyrins; D000077362:Verteporfin