title: Relationship of bispectral index to hemodynamic variables and alveolar concentration multiples of sevoflurane in puppies.
abstract: The relationships between bispectral index (BIS), cardiovascular variables and minimum alveolar concentration (MAC) multiples of sevoflurane in puppies were determined. Five puppies were anesthetized with sevoflurane on two occasions. First, the individual sevoflurane MAC values were determined for each puppy. Secondly, dogs were anesthetized with sevoflurane at each of 5 MAC multiples, 0.75, 1, 1.25, 1.5 and 1.75 MAC administered in random order. Hemodynamic parameters and BIS data were collected for 20min. Somatic stimulus was then applied and the same parameters and data were collected for 6min. Correlation between BIS and end tidal sevoflurane and between BIS and hemodynamic parameters were studied. We found positive significant correlation in both cases. BIS is lower in puppies that in adults at the same alveolar anesthetic concentrations and sevoflurane appears to be a safe anesthetic in puppies.
authors.affiliation: Department of Animal Medicine and Surgery, Veterinary School of Córdoba, Universtity of Córdoba, Francisco Santisteban Hospital, Campus de Rabanales 14014, Córdoba, Spain. v92moroj@uco.es
authors.forename: J
authors.initials: J
authors.lastname: Morgaz
authors.forename: M M
authors.initials: MM
authors.lastname: Granados
authors.forename: J M
authors.initials: JM
authors.lastname: Domínguez
authors.forename: R
authors.initials: R
authors.lastname: Navarrete
authors.forename: A
authors.initials: A
authors.lastname: Galán
authors.forename: J A
authors.initials: JA
authors.lastname: Fernández
authors.forename: R J
authors.initials: RJ
authors.lastname: Gómez-Villamandos
mesh_terms: D018685:Anesthetics, Inhalation / Q000493:pharmacokinetics / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D004285:Dogs; D004569:Electroencephalography / Q000187:drug effects; D004947:Esophagus; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007440:Intubation; D008297:Male; D008738:Methyl Ethers / Q000493:pharmacokinetics / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D018482:Muscle, Skeletal / Q000187:drug effects / Q000502:physiology; D012119:Respiration / Q000187:drug effects; D000077149:Sevoflurane; D014132:Trachea
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane