Actin-aggregating cucurbitacins from Physocarpus capitatus.
Bioassay-guided fractionation of Physocarpus capitatus yielded two new cucurbitacins (3 and 4) along with the known cucurbitacin F (1) and dihydrocucurbitacin F (2). Preliminary mechanism of action studies indicate that the cucurbitacins cause actin aggregates and inhibit cell division.
Maloney
Katherine N
KN
Department of Biological Chemistry and Molecular Pharmacology, and Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Fujita
Masaki
M
Eggert
Ulrike S
US
Schroeder
Frank C
FC
Field
Christine M
CM
Mitchison
Timothy J
TJ
Clardy
Jon
J
D000199:Actins / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D054728:Cucurbitacins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D048749:Cytokinesis / Q000187:drug effects; D004330:Drosophila; D027824:Rosaceae / Q000737:chemistry*; D014315:Triterpenes
D000199:Actins; D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; C098578:dihydrocucurbitacin F; C453923:cucurbitacin F; D054728:Cucurbitacins