Synthesis of substituted cinnamoyl-tyramine derivatives and their platelet anti-aggregatory activities.
Substituted cinnamoyl-tyramine derivatives were synthesized by DCC-coupling of substituted cinnamic acid with tyramine or tyramine methyl-1-ether to evaluate PAF-receptor binding antagonistic activities and inhibitory activities on PAF-induced platelet aggregation with interest on structure-activity relations. The results show that 3,4-dimethoxy-cinnamoyl tyramine-amide or its methyl ether have significant PAF-receptor binding antagonistic activity and platelet anti-aggregatory activities.
Woo
N T
NT
Il-Yang Central Research Institute, Hagal 182-4, Kiheung, Yongin, 449-900, Kyungki, Korea.
Jin
S Y
SY
Cho
D J
DJ
Kim
N S
NS
Bae
E H
EH
Han
D
D
Han
B H
BH
Kang
Y H
YH