title: Studies on the synthesis andin vitro anti-tumor activity of dihydroberberine derivatives.
abstract: Three types of dihydroberberine derivatives such as spirobenzylisoquinoline, benzindenoazepine and cyclopropanated quinolizine species were synthesized from dihydroberberine for the investigation on their anti-tumor activity. Among them, cyclopropanated quinolizine species were more effective than spirobenzylisoquinoline and benzindenoazepine against P-388 and L-1210 leukemia cell.
authors.affiliation: College of Pharmacy, Kyung Hee University, Hoeki-Dong, Dongdaemoon-Ku, 130-701, Seoul, Korea.
authors.forename: I J
authors.initials: IJ
authors.lastname: Kim
authors.forename: Y J
authors.initials: YJ
authors.lastname: Park
authors.forename: J I
authors.initials: JI
authors.lastname: Kim
authors.forename: K T
authors.initials: KT
authors.lastname: Lee
authors.forename: S K
authors.initials: SK
authors.lastname: Kim