title: Clinical and pathologic prognostic factors for curative resection for pancreatic cancer.
abstract: BACKGROUND
  Pancreatic cancer is the fifth leading cause of cancer-related deaths in the world. Operative resection is the only therapeutic option with curative potential for this disease.
  
  
  OBJECTIVE
  The aim of the present study was to correlate clinical and pathologic parameters with survival in patients submitted to pancreatic resection for pancreatic adenocarcinoma.
  
  
  METHODS
  Surgical resection with curative intent (R0 and R1 resections) was performed in 65 pancreatic cancer patients between 1990 and 2006. The overall results of surgical treatment were retrospectively analyzed and compared with the clinicopathologic features of these patients.
  
  
  RESULTS
  Pylorus-preserving pancreatoduodenectomy was performed in 37 patients (56.9%), classic resection in 35.4%, distal pancreatectomy in 4.6% and total pancreatectomy in 3.6%. The inhospital mortality was 5% (three patients). Postoperative complications occurred in 28 patients (43%). Mean survival and five-year survival rate after curative resection were 27 months and 9.0%, respectively. Sex, TNM stage, tumor differentiation, neural invasion, tumor size and involvement of resection margin were significant prognostic factors on univariate analysis. Multivariate analysis showed tumor differentiation and neural invasion as prognostic factors.
  
  
  CONCLUSIONS
  Patients with pancreatic cancer, even those with poor prognostic factors should be given the opportunity of surgical resection with curative intent.
authors.affiliation: Department of Gastroenterology, Surgical Division, Faculty of Medicine, São Paulo University, São Paulo, Brazil. marcos.perini@usp.br
authors.forename: M V
authors.initials: MV
authors.lastname: Perini
authors.forename: A L
authors.initials: AL
authors.lastname: Montagnini
authors.forename: J
authors.initials: J
authors.lastname: Jukemura
authors.forename: S
authors.initials: S
authors.lastname: Penteado
authors.forename: E E
authors.initials: EE
authors.lastname: Abdo
authors.forename: R
authors.initials: R
authors.lastname: Patzina
authors.forename: I
authors.initials: I
authors.lastname: Cecconello
authors.forename: J E M
authors.initials: JE
authors.lastname: Cunha