title: Chronic infections and atherosclerosis.
abstract: The immune response against heat shock protein 60 (HSP60) derived from pathogens causing chronic infections is thought to be an important pro-atherogenic mechanism because high serum levels of antibodies against HSP60 have been associated with atherosclerotic diseases, such as coronary artery diseases, or cerebro-vascular events. Furthermore, the presence of HSP60-specific T lymphocytes in circulation may increase the risk of atherosclerosis. Our recent in vitro and in vivo studies have also shown an association of Helicobacter pylori-HSP60 (Hp-HSP60) specific Th1 immune responses elicited by H. pylori infection with the progression of atherosclerosis in a hyperlipidemic mouse model. These Th1 dominant immune responses may cross-react with endogenous HSP60 expressed on stressed cells of the vascular endothelium, likely due to molecular mimicry. However, the exact mechanisms by which endothelial cells display their HSP60 molecule or present HSP60 antigenic epitopes on the surface are still unclear.
authors.affiliation: Department of Bacteriology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Ayada
authors.forename: Kenji
authors.initials: K
authors.lastname: Yokota
authors.forename: Kazuko
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Shoenfeld
authors.forename: Eiji
authors.initials: E
authors.lastname: Matsuura
authors.forename: Keiji
authors.initials: K
authors.lastname: Oguma
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000150:complications* / Q000276:immunology*; D018834:Chaperonin 60 / Q000276:immunology; D002908:Chronic Disease; D042783:Endothelial Cells / Q000276:immunology / Q000378:metabolism; D016481:Helicobacter Infections / Q000276:immunology; D016480:Helicobacter pylori / Q000276:immunology; D006801:Humans; D007239:Infections / Q000150:complications* / Q000276:immunology*; D051379:Mice
chemical_list: D018834:Chaperonin 60