Controlled release of heparin-binding growth factors using heparin-containing particulate systems for tissue regeneration.
The strategy of growth factor delivery to specific sites for therapeutic applications has been considered an essential process in biomedical fields despite some obstacles, such as a non-controlled release with initial burst. This article focuses on particulate systems using heparin for the controlled delivery of heparin-binding growth factors (HBGFs), an emerging area in the tissue engineering field. Since heparin has been widely utilized for growth factor delivery due to its electrostatic nature and specific affinity with HBGFs, heparin-containing polymeric particulates can be utilized as functional carriers to deliver growth factors in a controlled manner. In particular, examples of the HBGF delivery systems containing heparin, perspectives and potential applications are described and discussed.
Joung
Yoon Ki
YK
Ajou University, Department of Molecular Science and Technology, 5 Wonchon, Yeoungtong, Suwon 443-749, Republic of Korea.
Bae
Jin Woo
JW
Park
Ki Dong
KD
D000818:Animals; D000925:Anticoagulants / Q000008:administration & dosage* / Q000494:pharmacology*; D002240:Carbohydrate Sequence; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage / Q000494:pharmacology; D006493:Heparin / Q000008:administration & dosage* / Q000494:pharmacology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage* / Q000494:pharmacology*; D008969:Molecular Sequence Data; D020932:Nerve Growth Factor / Q000008:administration & dosage / Q000494:pharmacology; D012038:Regeneration / Q000187:drug effects*; D053773:Transforming Growth Factor beta1 / Q000008:administration & dosage / Q000494:pharmacology; D042461:Vascular Endothelial Growth Factor A / Q000008:administration & dosage / Q000494:pharmacology
D000925:Anticoagulants; D003692:Delayed-Action Preparations; D036341:Intercellular Signaling Peptides and Proteins; D053773:Transforming Growth Factor beta1; D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2; D006493:Heparin; D020932:Nerve Growth Factor