Kinetic study of N-bromosuccinimide reactions and kinetic determination of pyridoxine using a bromide-selective electrode.
The bromide released by the alkaline hydrolysis of N-bromosuccinimide and its reactions with bromide, pyridoxine and thiamine have been studied potentiometrically using a solid-state bromide-selective electrode to monitor the consumed or produced bromide ion. Potential-time indications are obtained using a microcomputer-controlled potentiometric system. The overall rate constants and the activation energies have been calculated. A kinetic-potentiometric procedure for the determination of pyridoxine in the presence of thiamine in pharmaceutical preparations, based on its reaction with N-bromosuccinimide, is presented.
Halvatzis
S A
SA
Laboratory of Analytical Chemistry, University of Athens, Panepistimiopolis, 157 71, Athens, Greece.
Timotheou-Potamia
M M
MM
Efstathiou
C E
CE