Renal cell carcinoma with rhabdoid features. Divergent differentiation of conventional (clear cell) carcinoma.
A rare case of renal cell carcinoma (RCC) with rhabdoid features in an adult man is presented. This tumor with rhabdoid features, also known as composite neoplasm, represents a pattern of progression emerging from specific histologic RCC types. RCC with rhabdoid features is a highly aggressive neoplasm and its malignant behavior may be due to the high-cell proliferation activity of the rhabdoid areas. Rhabdoid features in RCC may represent a final pathway of differentiation in clonal progression to a high-grade, aggressive biologic state.
Klimis
T
T
Department of Pathology, 3rd Hospital of Social Insurance Institute, and Athens University School of Medicine, Athens, Greece.
Karvounis
H
H
D014408:Biomarkers, Tumor / Q000378:metabolism; D002292:Carcinoma, Renal Cell / Q000378:metabolism / Q000473:pathology*; D049109:Cell Proliferation; D006801:Humans; D007124:Immunoenzyme Techniques; D007680:Kidney Neoplasms / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D018335:Rhabdoid Tumor / Q000378:metabolism / Q000473:pathology*
D014408:Biomarkers, Tumor