Ers controls glycerol metabolism in Enterococcus faecalis.
Ers is a pleiotropic transcriptional regulator in Enterococcus faecalis, an opportunistic bacterium. The authors have already shown that this protein is important for survival against oxidative stress and within macrophages as well as for survival of mice, and that Ers also is involved in the regulation of citrate and arginine metabolisms. The current study highlights the involvement of Ers also in the regulation of glycerol metabolism. The results suggest that EF0082, a known member of the Ers regulon encoding a major facilitator family transporter, may be able to transport glycerol. Moreover, the study demonstrates that Ers acts as a positive regulator of the glpKOF operon encoding glycerol kinase, glycerol-3-phosphate oxidase, and glycerol transport facilitator proteins.
Riboulet-Bisson
Eliette
E
Laboratoire de Microbiologie de l'Environnement, EA 956 soutenue par l'INRA, IFR 146, Université de Caen, 14032 Caen Cedex, France.
Hartke
Axel
A
Auffray
Yanick
Y
Giard
Jean-Christophe
JC
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D013293:Enterococcus faecalis / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D005990:Glycerol / Q000378:metabolism*; D005991:Glycerol Kinase / Q000235:genetics / Q000378:metabolism; D005993:Glycerolphosphate Dehydrogenase / Q000235:genetics / Q000378:metabolism; D009876:Operon; D018085:Regulon; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
D001426:Bacterial Proteins; D014157:Transcription Factors; D005993:Glycerolphosphate Dehydrogenase; C098831:glycerol-3-phosphate oxidase; D005991:Glycerol Kinase; D005990:Glycerol