Crystallization of organic crystals with "tailor-made" inhibitors. Determination of L-lysine using L-glutamic acid as substrate.
A very simple turbidimetric procedure is used for determination of L-lysine, based on its inhibitory action on the crystallization of L-glutamic acid. The obtention of supersaturated solutions of L-glutamic acid was accomplished by means of the change in the solvent composition. Thus, the addition of ethanol to stable aqueous solutions of this amino acid allows the obtainment of unstable supersaturated solutions. The method suffers from very few interferences and permits the development of an analytical procedure to determine L-lysine in the presence of D-lysine. The method was also applied to the determination of L-lysine in pharmaceutical products.
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F
Department of Chemistry, University of Balearic Islands, 07071 Palma de Mallorca, Spain.
Genestar
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C