title: Intraneural reticular perineurioma of the hypoglossal nerve.
abstract: BACKGROUND
  Intraneural perineurioma or reticular perineurioma, which is 1 variant of extraneural perineurioma, has been rarely reported in the head and neck region.
  
  
  METHODS
  We report a case of a 52-year-old woman who wasseen with a swelling in the neck. A mass was found located on the medial aspect of the left submandibular gland and was palpated with a sponge-like texture. The mass was seen as a homogenous semisolid lesion on CT and ultrasound examination.
  
  
  RESULTS
  Surgical exploration revealed expansion of the hypoglossal nerve. Microscopically, the tumor showed both pseudo-onion bulb, which is a feature of intraneural perineurioma, and reticular pattern with microcysts, which is a feature of reticular variant of extraneural perineurioma. The tumor cells were immunopositive for epithelial membrane antigen and human erythrocyte glucose transporter-1 (GLUT-1).
  
  
  CONCLUSIONS
  An intraneural reticular perineurioma of the hypoglossal nerve should be included in the differential diagnosis of submandibular swelling.
authors.affiliation: Department of Pathology, School of Medicine, Catholic University of Daegu, Daegu, South Korea.
authors.forename: Yoon Seup
authors.initials: YS
authors.lastname: Kum
authors.forename: Jeong Kyu
authors.initials: JK
authors.lastname: Kim
authors.forename: Chang Ho
authors.initials: CH
authors.lastname: Cho
authors.forename: Ho Kyun
authors.initials: HK
authors.lastname: Kim
mesh_terms: D001707:Biopsy, Needle; D003390:Cranial Nerve Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D005260:Female; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D007002:Hypoglossal Nerve / Q000473:pathology*; D007150:Immunohistochemistry; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D018317:Nerve Sheath Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D013363:Submandibular Gland / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed; D018608:Ultrasonography, Doppler