Comment on "Differential rescue of light- and food-entrainable circadian rhythms".
Fuller et al. (Reports, 23 May 2008, p. 1074) reported that the dorsomedial hypothalamus contains a Bmal1-based oscillator that can drive food-entrained circadian rhythms. We report that mice bearing a null mutation of Bmal1 exhibit normal food-anticipatory circadian rhythms. Lack of food anticipation in Bmal1-/- mice reported by Fuller et al. may reflect morbidity due to weight loss, thus raising questions about their conclusions.
Mistlberger
Ralph E
RE
Department of Psychology, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada. mistlber@sfu.ca
Yamazaki
Shin
S
Pendergast
Julie S
JS
Landry
Glenn J
GJ
Takumi
Toru
T
Nakamura
Wataru
W
D056930:ARNTL Transcription Factors; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000378:metabolism*; D001522:Behavior, Animal; D001683:Biological Clocks / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D003463:Cues; D003624:Darkness; D004302:Dorsomedial Hypothalamic Nucleus / Q000378:metabolism*; D005502:Food; D008027:Light; D051379:Mice; D009154:Mutation
D056930:ARNTL Transcription Factors; D051792:Basic Helix-Loop-Helix Proteins; C538961:Bmal1 protein, mouse