Zn(II) ions bind very efficiently to tandem repeat region of "prion related protein" (PrP-rel-2) of zebra-fish. MS and potentiometric evidence.
Multi-histidine peptide fragments of zebra-fish prion protein are effective ligands for Zn(II) ions. Moreover the formation of a dinuclear complex species with a longer peptide can suggest the existence of the cooperative effect in the metal ion binding.
Szyrwiel
Lukasz
L
Faculty of Chemistry, University of Wrocław, F. Joliot-Curie 14, 50383, Wroclaw, Poland.
Jankowska
Elzbieta
E
Janicka-Klos
Anna
A
Szewczuk
Zbigniew
Z
Valensin
Daniela
D
Kozlowski
Henryk
H
D000818:Animals; D002413:Cations, Divalent / Q000378:metabolism; D011199:Potentiometry; D011328:Prions / Q000378:metabolism*; D021241:Spectrometry, Mass, Electrospray Ionization; D020080:Tandem Repeat Sequences; D015027:Zebrafish / Q000378:metabolism; D015032:Zinc / Q000378:metabolism*
D002413:Cations, Divalent; D011328:Prions; D015032:Zinc