Exaggerated responses to stress in the BTBR T+tf/J mouse: an unusual behavioral phenotype.
This study shows that the BTBR T+tf/J mouse, a model for autism spectrum disorder (ASD), has increased levels of the stress hormone corticosterone, when compared to C57BL/6J mice. In addition, we have shown that tail suspension of the BTBR produces a heightened anxiety response in the elevated plus maze. These results suggest that the BTBR mouse is stressor-reactive exhibiting hormone responses that might predispose it to ASD.
Benno
Robert
R
William Paterson University of New Jersey, Department of Biology, 300 Pompton Road, Wayne, NJ 07470, United States. bennor@wpunj.edu
Smirnova
Yelena
Y
Vera
Susy
S
Liggett
Amanda
A
Schanz
Norman
N
D000818:Animals; D001007:Anxiety / Q000503:physiopathology* / Q000523:psychology; D001321:Autistic Disorder / Q000235:genetics / Q000503:physiopathology* / Q000523:psychology; D003345:Corticosterone / Q000097:blood*; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D005106:Exploratory Behavior / Q000502:physiology; D008297:Male; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D010641:Phenotype; D013312:Stress, Physiological / Q000502:physiology*
D003345:Corticosterone