Determination of benorilate in pharmaceutical formulations and its metabolite in urine at carbon paste electrode modified by silver nanoparticles.
Benorilate was determined by the differential pulse voltammetry (DPV) using a carbon paste electrode modified by silver nanoparticles in 1.25x10(-3)moll(-1) KH(2)PO(4) and Na(2)HPO(4) buffer solution (pH=6.88, 25 degrees C) .The anodic peak potential was +0.970V (versus SCE). A good linear relationship was realized between the anodic peak currents and benorilate concentrations in the range of 1.0x10(-7) to 2.5x10(-4)moll(-1) with the detection limit of 1.0x10(-8)moll(-1). The recovery was 95.2-103.6% with the relative standard deviation of 3.6% (n=9). The pharmaceutical preparations, benorilate tablets samples and its metabolite (salicylic acid) in urine were determined with the desirable results.
Wang
Cheng Yin
CY
Department of Chemistry and Chemical Engineering, Yangzhou University, 180 Siwangting lu, Yangzhou 225002, China.
Hu
Xiao Ya
XY