Separation and determination of mixtures containing p-aminosaucylic add and m-aminophenol.
A procedure is described for separating and determining p-anunosalicylie add and m-aminophenol m mixtures. Separation is effected by passing a solution of the mixture in dimethylformamide through a column of strong cation-exchange resin. The eluate containing the p-aminosalicylic acid is titrated with sodium methoxide. The m-aminophénol is eluted from the column with ethanolic HC1. The eluate is evaporated to dryness, the residue dissolved in acetic acid, and the solution titrated with perchloric add.
Blake
M I
MI
Department of Pharmacy University of Illinois at the Medical Center Chicago, Illinois 60612, U.S.A.
Hunt
J
J