title: An organocatalytic approach to the construction of chiral oxazolidinone rings and application in the synthesis of antibiotic linezolid and its analogues.
abstract: An efficient, catalytic asymmetric approach to antibacterial agent linezolid has been developed. The route features organocatalytic, highly enantioselective aldol and Beckman rearrangement reactions. The strategy has also been successfully applied for the preparation of new alpha-substituted analogues with high enantio- and diastereoselectivity.
authors.affiliation: Department of Pharmaceutical Sciences, School of Pharmacy, East China University of Science & Technology, Shanghai 200237, People's Republic of China.
authors.forename: Lirong
authors.initials: L
authors.lastname: Song
authors.forename: Xiaobei
authors.initials: X
authors.lastname: Chen
authors.forename: Shilei
authors.initials: S
authors.lastname: Zhang
authors.forename: Haoyi
authors.initials: H
authors.lastname: Zhang
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.forename: Guangshun
authors.initials: G
authors.lastname: Luo
authors.forename: Wenjing
authors.initials: W
authors.lastname: Liu
authors.forename: Wenhu
authors.initials: W
authors.lastname: Duan
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
mesh_terms: D000081:Acetamides / Q000138:chemical synthesis* / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D000069349:Linezolid; D023303:Oxazolidinones / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid