title: High frequency of venous thromboembolic events in Churg-Strauss syndrome, Wegener's granulomatosis and microscopic polyangiitis but not polyarteritis nodosa: a systematic retrospective study on 1130 patients.
abstract: OBJECTIVE
  To determine the frequency and risk factors of venous thromboembolic events (VTE) in Wegener's granulomatosis (WG), microscopic polyangiitis (MPA) and, the so far unstudied, Churg-Strauss syndrome (CSS) and polyarteritis nodosa (PAN).
  
  
  METHODS
  Retrospective, systematic analysis and comparisons were made between the characteristics of patients in the VTE group and non-VTE group. 1130 patients with WG, MPA, CSS or PAN were identified from the French Vasculitis Study Group cohort.
  
  
  RESULTS
  During a mean follow-up of 58.4 (45.8) months, 83 VTE occurred in 74 (6.5%) patients, with a median vasculitis-VTE diagnosis interval of 5.8 months (-3 to +156). VTE occurred in seven of 285 (2.5%) patients with PAN, 19 of 232 (8.2%) with CSS, 30 of 377 (8%) with WG and 18 of 236 (7.6%) with MPA. Multivariate analysis retained age, male sex or previous VTE or stroke with motor deficit as being associated with a higher VTE risk. The adjusted odds ratio (95% confidence interval) for VTE was 2.88 (1.27 to 6.50) for patients with WG, MPA or CSS compared with PAN (p = 0.01).
  
  
  CONCLUSIONS
  Our results suggest that, like WG and MPA, patients with CSS are at a greater risk of VTE, than those with PAN. The reasons for this difference remain to be elucidated.
authors.affiliation: The National Referral Center for Necrotizing Vasculitides and Systemic Sclerosis, Department of Internal Medicine, Université Paris Descartes, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Allenbach
authors.forename: R
authors.initials: R
authors.lastname: Seror
authors.forename: C
authors.initials: C
authors.lastname: Pagnoux
authors.forename: L
authors.initials: L
authors.lastname: Teixeira
authors.forename: P
authors.initials: P
authors.lastname: Guilpain
authors.forename: L
authors.initials: L
authors.lastname: Guillevin
mesh_terms: D000208:Acute Disease; D000328:Adult; D000367:Age Factors; D000368:Aged; D015267:Churg-Strauss Syndrome / Q000097:blood / Q000150:complications*; D005260:Female; D005500:Follow-Up Studies; D014890:Granulomatosis with Polyangiitis / Q000097:blood / Q000150:complications*; D006801:Humans; D015994:Incidence; D008297:Male; D015999:Multivariate Analysis; D010488:Polyarteritis Nodosa / Q000097:blood; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D014657:Vasculitis / Q000097:blood / Q000150:complications*; D020246:Venous Thrombosis / Q000097:blood / Q000150:complications*