Organocatalytic Michael addition of aldehydes to gamma-keto-alpha,beta-unsaturated esters. an efficient entry to versatile chiral building blocks.
The diarylprolinol ether/HOAc-catalyzed Michael addition of aldehydes to gamma-keto-alpha,beta-unsaturated esters occurs in a highly regioselective and enantioselective manner. The adducts could easily be converted into synthetically useful cyclohexenones, cyclohexanones, piperidines, and gamma-lactones.
Wang
Jing
J
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China.
Ma
Anqi
A
Ma
Dawei
D
D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D004952:Esters; D007659:Ketones / Q000737:chemistry*; D013237:Stereoisomerism
D000447:Aldehydes; D004952:Esters; D007659:Ketones