[Farnesol as a quorum-sensing molecule in Candida albicans].
Farnesol is one of the quorum sensing molecules of Candida albicans. In this report, we discuss the effects of farnesol on: 1. growth of Candida albicans in vitro and in vivo; 2. the incorporation of biomolecules into the cell wall of Candida albicans; and 3. cytokine expression by the immune system. Our results indicate genes of Candida albicans expressed at an early stage of quorum-sensing. Half of these genes are known and two-thirds of known genes are up-regulated by two types of transcription factors.
Cho
Tamaki
T
Section of Infection Biology, Department of Functional Bioscience, Fukuoka Dental College, Fukuoka, Japan.
Aoyama
Toshihiro
T
Toyoda
Mika
M
Nakayama
Hironobu
H
Chibana
Hiroji
H
Kaminishi
Hidenori
H
Calderone
Richard A
RA
D002176:Candida albicans / Q000254:growth & development*; D005204:Farnesol / Q000494:pharmacology*; D053038:Quorum Sensing / Q000502:physiology*
D005204:Farnesol