Expanding targets of vitamin D receptor activation: downregulation of several RAS components in the kidney.
Vitamin D receptor (VDR) activation has a beneficial influence on the progression of experimental renal insufficiency, and reduced renal tissue renin expression may play a role in this process. Freundlich and co-workers now report that VDR activation also suppresses the expression of angiotensinogen, angiotensin II type 1 receptor, and renin receptor in the kidneys of 5/6 nephrectomized rats, effects associated with reduced blood pressure and urinary protein excretion and with alleviated renal tissue damage.
Pörsti
Ilkka H
IH
Medical School, University of Tampere, Department of Internal Medicine, Tampere University Hospital, Tampere, Finland. ilkka.porsti@uta.fi
D000818:Animals; D016503:Drug Delivery Systems; D005786:Gene Expression Regulation; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D018167:Receptors, Calcitriol / Q000378:metabolism / Q000502:physiology*; D012084:Renin-Angiotensin System / Q000235:genetics; D018631:ras Proteins / Q000235:genetics*
D018167:Receptors, Calcitriol; D018631:ras Proteins