[Effect of estrogen on heat shock protein 70 expression in rat masseter muscle].
OBJECTIVE
To investigate the effect of estrogen on heat shock protein (HSP) 70 expression in rat masseter muscle.


METHODS
Sixty twelve-week-old female Sprague-Dawley rats were randomly divided into three groups: Sham surgery group (control group), ovariectomy group (OVX group), ovariectomy with estradiol valerate replacement treatment group (OVX/EV group). Half of the animals were sacrificed at 4 and 8 weeks respectively, then the masseter muscle was removed. Immunohistochemistry (IHC) method was employed to study the HSP70 expression in masseter muscle.


RESULTS
Compared to control group and OVX/EV group, the expression of HSP70 was significantly lower at 8 weeks in OVX group (P < 0.05). There were no significantly difference between the HSP70 expression of control group and that of OVX/EV group.


CONCLUSIONS
Estrogen may affect HSP70 expression in rat masseter muscle, and estrogen replacement therapy may prevent HSP70 reduction.
Li
Bing-yan
BY
State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China.
Zhao
Yu
Y
Li
Xiao-qing
XQ
Yi
Xin-zhu
XZ
Wang
Yan-min
YM
D000818:Animals; D004958:Estradiol / Q000031:analogs & derivatives; D004967:Estrogens; D005260:Female; D018840:HSP70 Heat-Shock Proteins; D006801:Humans; D008406:Masseter Muscle; D010052:Ovariectomy; D051381:Rats; D017207:Rats, Sprague-Dawley
D004967:Estrogens; D018840:HSP70 Heat-Shock Proteins; D004958:Estradiol