Microbial transformation of alantolactone by Mucor polymorphosporus.
Two new transformed sesquiterpenes of alantolactone by Mucor polymorphosporus were obtained. They were characterized as 3beta-hydroxy-11betaH-eudesm-5-en-8beta,12-olide (2) and 3beta,11alpha-dihydroxy-eudesm-5-en-8beta,12-olide (3), on the basis of spectral methods including 2D NMR. And product 3 was an unusual hydroxylation derivative of alantolactone at C-11.
Xin
Xiu-Lan
XL
The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.
Ma
Xiao-Chi
XC
Liu
Ke-Xin
KX
Han
Jian
J
Wang
Bao-Rong
BR
Guo
De-An
DA
D007783:Lactones / Q000737:chemistry* / Q000378:metabolism*; D015394:Molecular Structure; D009089:Mucor / Q000378:metabolism*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000378:metabolism*; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry* / Q000378:metabolism*
C539060:3beta,11alpha-dihydroxy-eudesm-5-en-8beta,12-olide; C539059:3beta-hydroxy-11betaH-eudesm-5-en-8beta,12-olide; D007783:Lactones; D012717:Sesquiterpenes; D045787:Sesquiterpenes, Eudesmane; C004363:alantolactone