Allometric prediction of the human pharmacokinetic parameters for naveglitazar.
Compounds that belong to the class known as dual (alpha,gamma) peroxisome proliferator-activated receptors (PPARs) show interesting pharmacological properties--regulation of blood glucose, fatty acids, and lipid parameters. Using the recently published preclinical data of naveglitazar, an allometric method was used to predict the human pharmacokinetic parameters (CL/F and Vss/F). The predicted parameters were compared to observed/predicted values of other important dual (a,y) PPAR compounds. The allometry data suggested that naviglitazar (CL/F) was at least 4 times faster than that of ragaglitazar, while the Vss was either equal to or 40% lower as compared to that of ragaglitazar.
Ahlawat
Preeti
P
Global Drug Development, ClinTec (India) International Pvt Ltd, Bangalore 560 078, India.
Srinivas
Nuggehally R
NR
D000818:Animals; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D006801:Humans; D051379:Mice; D008954:Models, Biological; D047493:PPAR alpha / Q000819:agonists; D047495:PPAR gamma / Q000819:agonists; D010666:Phenylpropionates / Q000493:pharmacokinetics* / Q000494:pharmacology; D011237:Predictive Value of Tests; D011817:Rabbits; D051381:Rats
D047493:PPAR alpha; D047495:PPAR gamma; D010666:Phenylpropionates; C517861:naveglitazar