title: Urological complications and their impact on survival after kidney transplantation from deceased cardiac death donors.
abstract: Urological complications after kidney transplantation may result in significant morbidity and mortality. However, the incidence of such complications after deceased cardiac death (DCD) donor kidney transplantation and their effect on survival is unknown. Purpose of this study was to estimate the incidence of urological complications after DCD kidney transplantation, and to estimate their impact on survival. Patient records of all 76 DCD kidney transplantations in the period 1997-2004 were reviewed for (urological) complications during the initial hospitalization until 30 days after discharge, and graft survival until the last hospital visit. Urological complications occurred in 32 patients (42.1%), with leakage and/or obstruction occurring in seven patients (9.2%). The latter seems to be comparable with the incidence reported in the literature for deceased heart-beating (DHB) transplantations (range 2.5-10%). Overall graft survival was 92% at 1 year and 88% at 3 years, comparable to the rates reported in the literature for kidneys from DHB donors, and was not affected by urological complications (chi(2) = 0.27, P = 0.61). Only a first warm-ischaemia time of 30 min or more reduced graft survival (chi(2) = 4.38, P < 0.05). We conclude that urological complications occur frequently after DCD kidney transplantation, but do not influence graft survival. The only risk factor for reduced graft survival in DCD transplant recipients was the first warm-ischaemia time.
authors.affiliation: Department of Transplantation Surgery, Leiden University Medical Centre, Leiden, The Netherlands.
authors.forename: Meriem
authors.initials: M
authors.lastname: Khairoun
authors.forename: Andrzej G
authors.initials: AG
authors.lastname: Baranski
authors.forename: Paul J M
authors.initials: PJ
authors.lastname: van der Boog
authors.forename: Ada
authors.initials: A
authors.lastname: Haasnoot
authors.forename: Marko J K
authors.initials: MJ
authors.lastname: Mallat
authors.forename: Perla J
authors.initials: PJ
authors.lastname: Marang-van de Mheen
mesh_terms: D000328:Adult; D000368:Aged; D003643:Death; D005260:Female; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D014019:Tissue Donors; D014570:Urologic Diseases / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality