Genetics of the Framingham Heart Study population.
This chapter provides an introduction to the Framingham Heart Study and the genetic research related to cardiovascular diseases conducted in this unique population. It briefly describes the origins of the study, the risk factors that contribute to heart disease, and the approaches taken to discover the genetic basis of some of these risk factors. The genetic architecture of several biological risk factors has been explained using family studies, segregation analysis, heritability, and phenotypic and genetic correlations. Many quantitative trait loci underlying cardiovascular diseases have been discovered using different molecular markers. Additionally, initial results from genome-wide association studies using 116,000 markers and the prospects of using 550,000 markers for association studies are presented. Finally, the use of this unique sample to study genotype and environment interactions is described.
Govindaraju
Diddahally R
DR
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118.
Adrienne Cupples
L
L
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118.
Kannel
William B
WB
NHLBI's Framingham Heart Study, Framingham, Massachusetts 01702.
O'Donnell
Christopher J
CJ
NHLBI's Framingham Heart Study, Framingham, Massachusetts 01702.
Atwood
Larry D
LD
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118.
D'Agostino
Ralph B
RB
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118; NHLBI's Framingham Heart Study, Framingham, Massachusetts 01702.
Fox
Caroline S
CS
NHLBI's Framingham Heart Study, Framingham, Massachusetts 01702.
Larson
Marty
M
NHLBI's Framingham Heart Study, Framingham, Massachusetts 01702.
Levy
Daniel
D
NHLBI's Framingham Heart Study, Framingham, Massachusetts 01702.
Murabito
Joanne
J
NHLBI's Framingham Heart Study, Framingham, Massachusetts 01702; Section of General Internal Medicine, Boston University School of Medicine, Boston, Massachusetts 02118.
Vasan
Ramachandran S
RS
NHLBI's Framingham Heart Study, Framingham, Massachusetts 01702; Department of Cardiology, Boston University School of Medicine, Boston, Massachusetts 02118; Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts 02118.
Lee Splansky
Greta
G
NHLBI's Framingham Heart Study, Framingham, Massachusetts 01702.
Wolf
Philip A
PA
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118.
Benjamin
Emelia J
EJ
NHLBI's Framingham Heart Study, Framingham, Massachusetts 01702; Department of Cardiology, Boston University School of Medicine, Boston, Massachusetts 02118; Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts 02118.
D000465:Algorithms; D015988:Cohort Effect; D015331:Cohort Studies; D004777:Environment; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population / Q000941:ethics; D006331:Heart Diseases / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D040582:Inheritance Patterns; D008404:Massachusetts / Q000453:epidemiology; D044382:Population Groups / Q000235:genetics