title: A cross-sectional, mono-centric pilot study of insulin resistance in enzyme replacement therapy patients with Gaucher type I without overweight.
abstract: Insulin resistance have been demonstrated in untreated patients with Gaucher type I disease. It was implied in overweight enzyme replacement therapy (ERT) treated patients with Gaucher type I disease. In present study we investigate whether insulin resistance is presented in fourteen ERT treated patients with Gaucher type I disease and without overweight in comparison to normal subjects. This work illustrates the presence of insulin resistance in non-overweight ERT treated patients with Gaucher type I disease.
authors.affiliation: Ege University Medical Faculty, Department of Pediatric Endocrinology and Metabolism, Bornova 35100, Turkey. semakalkan@hotmail.com
authors.forename: Sema Kalkan
authors.initials: SK
authors.lastname: Ucar
authors.forename: Mahmut
authors.initials: M
authors.lastname: Coker
authors.forename: Mehmet
authors.initials: M
authors.lastname: Argin
authors.forename: Sezin
authors.initials: S
authors.lastname: Akman
authors.forename: Sinan
authors.initials: S
authors.lastname: Kara
authors.forename: Damla Goksen
authors.initials: DG
authors.lastname: Simsek
authors.forename: Sukran
authors.initials: S
authors.lastname: Darcan
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D005776:Gaucher Disease / Q000188:drug therapy* / Q000201:enzymology*; D005962:Glucosylceramidase / Q000235:genetics / Q000627:therapeutic use*; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D009154:Mutation; D050177:Overweight; D010865:Pilot Projects
chemical_list: D005962:Glucosylceramidase