Expression of HIF-1, galectin-3, cox-2 and Wilms tumor-1 protein in multiple schwannomas of the conus medullaris.
Schwannomatosis is a clinical syndrome that requires thorough clinical and radiological assessments before the diagnosis is made. Although schwannomatosis has been reported before, all were in multiple organ sites. The authors report a case of multiple intra-dural schwannomas of the conus medullaris expressing HIF-1, galectin-3, cox-2 and Wilms tumor-1 protein; which to the best of our knowledge has not been previously reported in schwanomatosis.
Sarwat
Amr M
AM
Department of Neurosurgery, Tawam Hospital, and Department of Pathology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE. asarwat@eim.ae
Al-Salam
Suhail
S
D018797:Cell Cycle Proteins; D051546:Cyclooxygenase 2 / Q000096:biosynthesis*; D037502:Galectin 3 / Q000096:biosynthesis*; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000096:biosynthesis*; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009442:Neurilemmoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D019635:Neurosurgical Procedures; D009687:Nuclear Proteins / Q000096:biosynthesis*; D000072260:RNA Splicing Factors; D013120:Spinal Cord Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery
D018797:Cell Cycle Proteins; D037502:Galectin 3; C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D009687:Nuclear Proteins; D000072260:RNA Splicing Factors; C419554:WTAP protein, human; D051546:Cyclooxygenase 2