[Monotherapy of epilepsy in women: psychiatric and neuroendocrine aspects].
An aim of the study was a comparative evaluation of efficacy and safety of traditional and modern antiepileptic drugs in women of reproductive age. A main group of patients consisted of 65 women, including 48 patients with partial epilepsy and 17 - with idiopathic generalized epilepsy. Some issues are solved in the study of a larger group comprising 110 patients (65 female and 45 male). The following drugs have been studied: topamax, valproates, carbamazepines and barbiturates. All of them were used as a monotherapy. Patient's state was assessed using clinical, neuropsychological and hormonal parameters. A general conclusion is that topamax is most beneficial, comparing with other drugs studied, in the treatment of women with epilepsy.
Zheleznova
E V
EV
Kalinin
V V
VV
Zemlianaia
A A
AA
Sokolova
L V
LV
Medvedev
I L
IL
D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D011594:Psychometrics / Q000379:methods; D016896:Treatment Outcome
D000927:Anticonvulsants; D012739:Gonadal Steroid Hormones