Consensus statement on the revised World Health Organization recommendations for BCG vaccination in HIV-infected infants.
This document outlines the consensus agreement from the Union's BCG Working Group regarding BCG vaccination in HIV-infected infants, in response to recently revised World Health Organization (WHO) guidelines, which make HIV infection in infants a full contraindication to bacille Calmette-Guérin (BCG) vaccination. BCG is one of the most widely given vaccines globally and is safe in immunocompetent individuals. Recent evidence shows that HIV-infected infants who were routinely vaccinated with BCG at birth, when asymptomatic, and who later developed AIDS, are at high risk of developing disseminated BCG disease (estimated incidence 407-1300 per 100 000). The document outlines requirements to implement selective BCG vaccination strategies in infants born to HIV-infected women and strategies to reduce the risk of vertical HIV transmission and disseminated BCG disease in infants.
Hesseling
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Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Tygerberg, South Africa. annekeh@sun.ac.za
Cotton
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Fordham von Reyn
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Graham
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Gie
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Hussey
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D001500:BCG Vaccine / Q000008:administration & dosage* / Q000009:adverse effects; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D014611:Vaccination / Q000592:standards; D014944:World Health Organization
D001500:BCG Vaccine