title: Complete recovery of an aged patient with Guillain-Barré syndrome associated with multiple IgM anti-ganglioside antibodies.
abstract: In this report we describe a 72-year-old woman who had cytomegalovirus infection-related Guillain-Barré syndrome (GBS) associated with multiple immunoglobulin M (IgM) anti-ganglioside antibodies. She became tetraplegic with respiratory failure, but recovered completely after intravenous immunoglobulin therapy and plasmapheresis. The serum contained high-titer IgM antibody activities to several gangliosides with disialosyl residues (GD1b, GD3, GT1b, GQ1b, and GT1a) and GD1a. These antibodies are often found in sera from patients with chronic sensory ataxic neuropathy, but they occur rarely in GBS.
authors.affiliation: Department of Neurology, Nara Medical University, Kashihara, Nara 634-8521, Japan. yoshikof@naramed-u.ac.jp
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Furiya
authors.forename: Makito
authors.initials: M
authors.lastname: Hirano
authors.forename: Susumu
authors.initials: S
authors.lastname: Kusunoki
authors.forename: Masami
authors.initials: M
authors.lastname: Ueda
authors.forename: Kazuma
authors.initials: K
authors.lastname: Sugie
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Nishiwaki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ueno
mesh_terms: D000368:Aged; D001706:Biopsy; D003586:Cytomegalovirus Infections / Q000150:complications; D005260:Female; D005732:Gangliosides / Q000276:immunology*; D020275:Guillain-Barre Syndrome / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood / Q000627:therapeutic use*; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007167:Immunotherapy; D009431:Neural Conduction / Q000502:physiology; D013497:Sural Nerve / Q000473:pathology
chemical_list: D005732:Gangliosides; D007075:Immunoglobulin M; D016756:Immunoglobulins, Intravenous