title: A modular and organocatalytic approach to gamma-butyrolactone autoregulators from Streptomycetes.
abstract: A general synthesis of optically active gamma-butyrolactone autoregulators is developed by a two-step sequence to assemble 2,3-trans-disubstituted butyrolactones in high yields and enantioselectivities; the scope of this reaction was elaborated by setting up a library of alkyl-substituted butyrolactones and the synthesis of the autoregulators IM-2 and VB-D.
authors.affiliation: Danish National Research Foundation: Center for Catalysis, Department of Chemistry, Aarhus University, Aarhus C, DK-8000, Denmark.
authors.forename: Petteri
authors.initials: P
authors.lastname: Elsner
authors.forename: Hao
authors.initials: H
authors.lastname: Jiang
authors.forename: Johanne B
authors.initials: JB
authors.lastname: Nielsen
authors.forename: Filippo
authors.initials: F
authors.lastname: Pasi
authors.forename: Karl Anker
authors.initials: KA
authors.lastname: Jørgensen
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry*
chemical_list: C107543:IM 2 autoregulator; D015107:4-Butyrolactone