A new phloroglucinol diglycoside derivative from Hypericum japonicum Thunb.
A new phloroglucinol diglycoside 1, together with eight known compounds, were isolated from Hypericum japonicum Thunb. The structure of the new compound 1 was determined by spectroscopic methods to be 4,6-dimethyl-5-O-[alpha-L-rhamnopyranosyl-(1-->6)-alpha-D-glucopyranosyl] multifidol. Different solvent extracts of Hypericum japonicum Thunb. were tested for in vivo antihypoxic activity using mice, with the EtOAc extract showing better activity.
Wang
Xiao Wei
XW
Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang, Liaoning, PR China.
Mao
Yu
Y
Wang
Nai-Li
NL
Yao
Xin Sheng
XS
D000818:Animals; D004187:Disaccharides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020902:Hypericum / Q000737:chemistry*; D000860:Hypoxia / Q000188:drug therapy*; D051379:Mice; D015394:Molecular Structure; D013057:Spectrum Analysis
C534556:4,6-dimethyl-5-O-(alpha-L-rhamnopyranosyl-(1-6)-alpha-D-glucopyranosyl); D004187:Disaccharides; D006027:Glycosides