title: Blood compatibility evaluation of elastic gelatin gel from salmon collagen.
abstract: Blood compatibility of a novel elastic gelatin gel (e-gel) from salmon collagen was evaluated. After a 10-min incubation of the e-gel with rat whole blood, there was a macroscopically small thrombus formation on the e-gel. Microscopic observation revealed that few platelets had adhered to the e-gel. Furthermore, the platelet adhesion rate was markedly lower on the e-gel compared to collagen-coated and fibrinogen-coated surfaces. Comparable results were obtained with re-crosslinked e-gel. In conclusion, the e-gel demonstrated good blood compatibility.
authors.affiliation: Creative Research Initiative "Sousei" (CRIS), Hokkaido University, N21-W10, Kita-ku, Sapporo, Hokkaido 001-0021, Japan. nagai491@yahoo.co.jp
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Nagai
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Kubota
authors.forename: Ryohei
authors.initials: R
authors.lastname: Okahashi
authors.forename: Masanobu
authors.initials: M
authors.lastname: Munekata
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000737:chemistry; D003094:Collagen / Q000737:chemistry*; D004548:Elasticity; D005340:Fibrinogen / Q000737:chemistry; D005780:Gelatin / Q000737:chemistry*; D005782:Gels; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D010973:Platelet Adhesiveness; D051381:Rats; D012474:Salmon; D013499:Surface Properties; D013927:Thrombosis / Q000378:metabolism; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D005782:Gels; D005780:Gelatin; D005340:Fibrinogen; D003094:Collagen