title: Myocardial tissue oxygenation estimated with calibrated diffuse reflectance spectroscopy during coronary artery bypass grafting.
abstract: We present a study using a method able to assess tissue oxygenation, taking into account the absorption and the level of scattering in myocardial tissue using a calibrated fiber optic probe. With this method, interindividual comparisons of oxygenation can be made despite varying tissue optical properties during coronary artery bypass grafting (CABG). During CABG, there are needs for methods allowing continuous monitoring and prediction of the metabolism in the myocardial tissue. 14 patients undergoing CABG are investigated for tissue oxygenation during different surgical phases using a handheld fiber optic spectroscopic probe with a source-detector distance of less than 1 mm. The probe is calibrated using a light transport model, relating the absorption and reduced scattering coefficients (mu(a) and mu(s)') to the measured spectra. By solving the inverse problem, absolute measures of tissue oxygenation are evaluated by the sum of oxygenized hemoglobin and myoglobin. Agreement between the model and measurements is obtained with an average correlation coefficient R2 of 0.96. Oxygenation is found to be significantly elevated after aorta cross-clamping and cardioplegic infusion, as well as after reperfusion, compared to a baseline (p<0.05). Tissue oxygenation decreases during cardiac arrest and increases after reperfusion.
authors.affiliation: Linköping University, Department of Biomedical Engineering, Linköping Biomedical Optics Group, Linköping, Sweden. eriha@imt.liu.se
authors.forename: Erik
authors.initials: E
authors.lastname: Häggblad
authors.forename: Tobias
authors.initials: T
authors.lastname: Lindbergh
authors.forename: M G Daniel
authors.initials: MG
authors.lastname: Karlsson
authors.forename: Henrik
authors.initials: H
authors.lastname: Casimir-Ahn
authors.forename: E Göran
authors.initials: EG
authors.lastname: Salerud
authors.forename: Tomas
authors.initials: T
authors.lastname: Strömberg
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002138:Calibration; D017076:Computer-Aided Design; D001026:Coronary Artery Bypass / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D010092:Oximetry / Q000295:instrumentation* / Q000379:methods / Q000592:standards; D010100:Oxygen / Q000032:analysis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013057:Spectrum Analysis / Q000295:instrumentation* / Q000379:methods / Q000592:standards
chemical_list: D010100:Oxygen