Target-selective photo-degradation of HIV-1 protease by a fullerene-sugar hybrid.
A designed fullerene-sugar hybrid effectively and selectively degraded the target protein, HIV-1 protease, which has high affinity for the fullerene moiety; degradation was achieved using long-wavelength UV or visible photo-irradiation, in the absence of any additives and under neutral conditions.
Tanimoto
Shuho
S
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, 223-8522, Japan.
Sakai
Satoshi
S
Matsumura
Shuichi
S
Takahashi
Daisuke
D
Toshima
Kazunobu
K
D002241:Carbohydrates / Q000737:chemistry; D037741:Fullerenes / Q000737:chemistry*; D016333:HIV Protease / Q000378:metabolism*; D008027:Light; D010782:Photolysis; D017382:Reactive Oxygen Species / Q000378:metabolism; D014466:Ultraviolet Rays
D002241:Carbohydrates; D037741:Fullerenes; D017382:Reactive Oxygen Species; D016333:HIV Protease; C514803:p16 protease, Human immunodeficiency virus 1