title: Effect of polymorphism in the leukemia inhibitory factor gene on litter size in Large White pigs.
abstract: DNA polymorphism of the porcine leukemia inhibitory factory (LIF) was investigated and used to study the effects on litter size in Large White pigs. A total of 2,167 litter records from 420 sows genotyped at two SNP loci (LIF1 and LIF2) within LIF gene were analyzed to determine whether LIF influenced total number born (TNB) and number born alive (NBA). The results indicated that B allele at LIF1 locus and A allele at LIF2 locus seem to have advantageous effects on litter size. However, the combined analyzed results demonstrated that genotype AAAA, ABBB, and BBBB are better than genotype AAAB, AABB, and ABAB for TNB and NBA in either third to eighth parity or all parities. In all parities, the sows with AAAA genotype had an advantage of 1.76 piglets (P < 0.001) for TNB and 1.44 piglets (P < 0.01) for NBA per litter over the AAAB sows, respectively. The results in this study demonstrated that LIF gene was significantly associated with litter size in pigs.
authors.affiliation: College of Animal Science and Technology & Key Laboratory for Animal Genetics and Breeding of Ministry of Agriculture, China Agricultural University, Beijing, China.
authors.forename: H C
authors.initials: HC
authors.lastname: Lin
authors.forename: G F
authors.initials: GF
authors.lastname: Liu
authors.forename: A G
authors.initials: AG
authors.lastname: Wang
authors.forename: L J
authors.initials: LJ
authors.lastname: Kong
authors.forename: X F
authors.initials: XF
authors.lastname: Wang
authors.forename: J L
authors.initials: JL
authors.lastname: Fu
mesh_terms: D000818:Animals; D005787:Gene Frequency; D005838:Genotype; D053605:Leukemia Inhibitory Factor / Q000235:genetics*; D008098:Litter Size / Q000235:genetics*; D036801:Parturition; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018807:Polymorphism, Single-Stranded Conformational; D034421:Sus scrofa / Q000235:genetics*
chemical_list: D053605:Leukemia Inhibitory Factor