Endometrial polyps and associated factors in Danish women aged 36-74 years.
OBJECTIVE
To identify factors associated with endometrial polyps.


METHODS
Case-control study of 140 women with endometrial polyps and 367 controls. Information on potentially associated factors was obtained by a validated questionnaire.


RESULTS
In an age-adjusted logistic regression model, the following was positively associated with endometrial polyps: current use of hormone therapy (odds ratio, 2.81; 95% CI, 1.29-6.13) and being overweight (body mass index > 25 kg/m(2)) (odds ratio, 2.06; 95% CI, 1.12-3.79) (postmenopausal women). Negatively associated was use of oral contraceptive pills (odds ratio, 0.20; 95% CI, 0.06-0.66). Histopathology diagnosed benign endometrial polyps (n = 137), polyp with premalignant disease (n = 3), and benign polyp with concomitant complex hyperplasia/endometrial cancer (n = 3).


CONCLUSIONS
Being overweight and current use of hormone therapy in postmenopausal women were positively associated, whereas the use of oral contraceptive pills was negatively associated with endometrial polyps. Hypertension and cervical polyps were not associated with endometrial polyps. Endometrial polyps were infrequently related to premalignant and malignant disease.
Dreisler
Eva
E
Department of Obstetrics and Gynecology, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark.
Sorensen
Soren Stampe
SS
Lose
Gunnar
G
D000328:Adult; D000367:Age Factors; D016022:Case-Control Studies; D003718:Denmark; D016889:Endometrial Neoplasms / Q000453:epidemiology*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008593:Menopause; D008875:Middle Aged; D011127:Polyps; D011446:Prospective Studies