title: Idiopathic orbital inflammatory disease successfully treated with rituximab.
abstract: We report a case of a 66-year-old Caucasian female with a diagnosis of idiopathic orbital inflammatory disease (OID) refractory to azathioprine therapy. The coexistence of diabetes mellitus represented a relative contraindication to chronic prednisone use. After two infusions of rituximab, a chimeric anti-CD20+ antibody, ophthalmic signs and symptoms remarkably improved. To our knowledge, this is the first case of idiopathic OID successfully treated with rituximab.
authors.affiliation: Department of Internal Medicine and Rheumatology, Bom Jesus Hospital, Ponta Grossa, PR, Brazil. marceloschafranski@yahoo.com.br
authors.forename: Marcelo Derbli
authors.initials: MD
authors.lastname: Schafranski
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D058846:Antibodies, Monoclonal, Murine-Derived; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001379:Azathioprine / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008882:Mikulicz' Disease / Q000175:diagnosis; D016727:Orbital Pseudotumor / Q000175:diagnosis / Q000188:drug therapy*; D000069283:Rituximab; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D018501:Antirheumatic Agents; D000069283:Rituximab; D001379:Azathioprine