title: The first synthesis of N-acetylneuraminic acid 1,7-lactone.
abstract: N-Acetylneuraminic acid is transformed into its until now unavailable and rather unwieldy 1,7-lactone, via the manageable 2-benzyloxycarbonyl N-acetylneuraminic acid 1,7-lactone which generates the free lactone in quantitative yield by hydrogenolysis.
authors.affiliation: Department of Chemistry, Biochemistry and Biotechnology for the Medicine, Via Saldini 50, Milano, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Colombo
authors.forename: Mario
authors.initials: M
authors.lastname: Anastasia
authors.forename: Paola
authors.initials: P
authors.lastname: Rota
authors.forename: Pietro
authors.initials: P
authors.lastname: Allevi
mesh_terms: D002236:Carbohydrate Conformation; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D012794:Sialic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D007783:Lactones; C534256:N-acetylneuraminic acid 1,7-lactone; D012794:Sialic Acids