[An experimental observation of pulmonary fibrosis in rats and its transforming growth factor beta1 treated by total hedysarum polybotyssaccharide].
OBJECTIVE
To treat pulmonary fibrosis and study its mechanisms.


METHODS
Choosing randomly 24 Wistar rats with normal sodium intratracheal injection as normal control group, the rests with heomycin A5 induced fibrosis were divided randomly into model group 24 as positive control, prednisone group 24, total hedysarum polybotyssaccharide (THPS) group 24, THPS and small dose prednisone group 24, and treated with different drugs. 6 rats of every group were put to death and observed pathological section, using imaging processing computer to quantitative analysis histomorphology, collagen, and transforming growth beta1, (TGF-beta1) on 7, 14, 30, 60 days.


RESULTS
The group treated by THPS combination small dose prednisone showed up the most effects in the 3 treatment groups.


CONCLUSIONS
THPS combination small dose prednisone to treat pulmonary fibrosis of rats is better than classic ways and its efficacy of inhibition TGF-beta1 may be a mechanism.
Lei
Feng-Feng
FF
Institute of the Combination of Traditional Chinese and Western Medicine in Lanzhou University, Lanzhou 730000, China.
Zhao
Jian-Xiong
JX
Wang
Xue-Xi
XX
Yao
Bao-Tai
BT
Ding
Kan
K
D000818:Animals; D001761:Bleomycin; D003094:Collagen / Q000378:metabolism; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D007887:Fabaceae / Q000737:chemistry*; D005260:Female; D007150:Immunohistochemistry; D008168:Lung / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D011134:Polysaccharides / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011239:Prednisolone / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D053773:Transforming Growth Factor beta1 / Q000378:metabolism*
D004365:Drugs, Chinese Herbal; D011134:Polysaccharides; D053773:Transforming Growth Factor beta1; D001761:Bleomycin; D003094:Collagen; D011239:Prednisolone