title: Effective avoidance of a functional spect-perfused lung using intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC): an update of a planning study.
abstract: IMRT and 3-dimensional conformal radiotherapy (3-DCRT) plans of 25 patients with non-small cell lung (NSCLC) were compared in terms of planning target volume (PTV) coverage and sparing of functional lung (FL) defined by a SPECT perfusion scan. IMRT resulted in significant reduction of functional V(20) and mean lung dose in stage III patients with inhomogeneous hypoperfusion. If the dose to FL is shown to be the determinant of lung toxicity, IMRT would allow for effective dose escalation by specific avoidance of functional lung.
authors.affiliation: Lung Research Unit, The Royal Marsden NHS Foundation Trust, Sutton, Surrey, UK. constant@bgu.ac.il
authors.forename: Konstantin
authors.initials: K
authors.lastname: Lavrenkov
authors.forename: Shalini
authors.initials: S
authors.lastname: Singh
authors.forename: Judith A
authors.initials: JA
authors.lastname: Christian
authors.forename: Mike
authors.initials: M
authors.lastname: Partridge
authors.forename: Elena
authors.initials: E
authors.lastname: Nioutsikou
authors.forename: Gary
authors.initials: G
authors.lastname: Cook
authors.forename: James L
authors.initials: JL
authors.lastname: Bedford
authors.forename: Michael
authors.initials: M
authors.lastname: Brada
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy*; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*