title: Ependymoma of the sella turcica: a variant of pituicytoma.
abstract: A broad spectrum of neoplasms affects the sellar region. Among these, gliomas are rare, most being tumors of pituicytes such as granular cell tumor and pituicytoma. Only 4 ependymomas of the human sellar region have been reported to date and all have had classic histologic features. Herein, we describe the clinicopathologic features of a sellar, low-grade ependymoma with unusual histology, but classic ultrastructural features, occurring in an elderly patient and thus expanding the spectrum of reported cases. The literature is reviewed and concepts of histogenesis are explored, particularly an origin in "ependymal pituicytes." The concept that sellar ependymoma is pituicyte-derived is explored.
authors.affiliation: Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN 55905, USA. scheithauer.bernd@mayo.edu
authors.forename: Bernd W
authors.initials: BW
authors.lastname: Scheithauer
authors.forename: Brooke
authors.initials: B
authors.lastname: Swearingen
authors.forename: E Tessa Hedley
authors.initials: ET
authors.lastname: Whyte
authors.forename: Pavan K
authors.initials: PK
authors.lastname: Auluck
authors.forename: Anat O
authors.initials: AO
authors.lastname: Stemmer-Rachamimov
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D003937:Diagnosis, Differential; D004806:Ependymoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007124:Immunoenzyme Techniques; D007382:Intermediate Filaments / Q000648:ultrastructure; D008297:Male; D008579:Meningioma / Q000175:diagnosis; D046529:Microscopy, Electron, Transmission; D010904:Pituitary Gland, Posterior / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D010911:Pituitary Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D012509:Sarcoma / Q000175:diagnosis; D012658:Sella Turcica / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor