Exploiting the natural metabolic diversity of Streptomyces venezuelae to generate unusual reduced macrolides.
An unusual set of reduced macrolide antibiotics was discovered by combination of organic synthesis and a biosynthetic approach using the unique metabolic diversity of Streptomyces venezuelae; two unnatural 16-membered ring macrolides are also created by employing this bio-catalyst.
Park
Je Won
JW
Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, Republic of Korea.
Oh
Hong-Se
HS
Jung
Won Seok
WS
Park
Sung Ryeol
SR
Han
Ah Reum
AR
Ban
Yeon-Hee
YH
Kim
Eun Ji
EJ
Kang
Han-Young
HY
Yoon
Yeo Joon
YJ
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology; D052978:Disk Diffusion Antimicrobial Tests; D018942:Macrolides / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D005810:Multigene Family; D013302:Streptomyces / Q000235:genetics / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D018942:Macrolides