[Analysis of sodium benzoate biotoxicity by atomic force microscope].
Atomic force microscope (AFM) was used to study biotoxicity of food preservative sodium benzoate (SB) at the single cellular level. Lymphocyte morphology and membrane ultrastructure treated with SB at different concentrations and time were analyzed visually. As compared to the normal lymphocyte, the cell morphology and membrane was significantly changed and its ultrastructure was also complicated. After treated with SB, the Rp-v, Rq, Ra and Z values were changed. The statistical analysis of lymphocytes after treated with SB was studied, and discussed its mechanism.
Hu
Mingqian
M
Chemistry Department, Jinan University, Guangzhou 510632, China.
Wang
Jiongkun
J
Cai
Jiye
J
Wu
Yangzhe
Y
Wang
Xiaoping
X
D000818:Animals; D002462:Cell Membrane / Q000648:ultrastructure; D008214:Lymphocytes / Q000187:drug effects* / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D018625:Microscopy, Atomic Force; D020160:Sodium Benzoate / Q000633:toxicity*
D020160:Sodium Benzoate