title: Chlorhexidine gluconate in endodontics: an update review.
abstract: The major objective in root canal therapy is to disinfect the entire root canal system. This requires that the pulpal contents be eliminated as sources of infection. This goal may be accomplished using mechanical instrumentation and chemical irrigation, in conjunction with medication of the root canal between treatment sessions. Microorganisms and their by-products are considered to be the major cause of pulpal and periradicular pathosis. In order to reduce or eliminate bacteria, various irrigation solutions have been used during treatment. Chlorhexidine is a cationic molecule which can be used during treatment. It has a wide range antimicrobial activity. Furthermore, because of its cationic structure, chlorhexidine has a unique property named substantivity. The purpose of this paper is to review different aspects of the use of chlorhexidine gluconate in endodontics.
authors.affiliation: mohammadi_zahed@yahoo.com
authors.forename: Zahed Mohamadi
authors.initials: ZM
authors.lastname: Kanisavaran
mesh_terms: D000891:Anti-Infective Agents, Local / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D001419:Bacteria / Q000187:drug effects; D018441:Biofilms / Q000187:drug effects; D002021:Buffers; D002126:Calcium Hydroxide / Q000494:pharmacology; D002175:Candida / Q000187:drug effects; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D003804:Dentin / Q000737:chemistry; D004342:Drug Hypersensitivity; D004347:Drug Interactions; D004847:Epithelial Cells / Q000187:drug effects; D006801:Humans; D012388:Root Canal Irrigants / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D012995:Solubility
chemical_list: D000891:Anti-Infective Agents, Local; D002021:Buffers; D012388:Root Canal Irrigants; C010882:chlorhexidine gluconate; D002126:Calcium Hydroxide; D002710:Chlorhexidine