Tandem conjugate addition-elimination reaction promoted by chiral pyrrolidinyl sulfonamide (CPS).
Chiral pyrrolidinyl sulfonamides have been found to promote the conjugate addition-elimination reaction between activated allylic bromides and 1,3-dicarbonyl compounds with high enantioselectivities and the highly functionalised products can be used to generate a variety of interesting enantiomerically pure compounds via simple transformations.
Xu
Junye
J
Department of Chemistry, National University of Singapore, Singapore.
Fu
Xiao
X
Low
Ruijuan
R
Goh
Yong-Peng
YP
Jiang
Zhiyong
Z
Tan
Choon-Hong
CH
D006842:Hydrocarbons, Brominated / Q000737:chemistry; D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry; D008314:Malonates / Q000737:chemistry; D015394:Molecular Structure; D011759:Pyrrolidines / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry*
D006842:Hydrocarbons, Brominated; D007659:Ketones; D008314:Malonates; D011759:Pyrrolidines; D013449:Sulfonamides