title: Elevated pretreatment interleukin-10 serum level is an International Prognostic Score (IPS)-independent risk factor for early treatment failure in advanced stage Hodgkin lymphoma.
abstract: Early treatment failure is still a clinical challenge despite high cure rates in Hodgkin lymphoma (HL) patients. To identify the biological risk factors predicting early treatment failure, we performed a retrospective case-control study. Forty-seven pretherapeutic serum samples were available from 47 advanced stage HL patients with early treatment failure and from 47 matched controls in complete remission. All patients were treated within German Hodgkin Study Group phase 3 trials. Matching was done according to treatment, stage, age, gender, International Prognostic Score (IPS) and histological subtype. Pretreatment serum levels of 30 cytokines, chemokines and soluble receptors were determined using immunoassays and flow cytometer based cytometric bead arrays. Only interleukin-10 serum levels were significantly associated with early treatment failure after statistical correction for multitesting (paired-sign test, p = 0.0008). In summary, pretherapeutic interleukin-10 levels are associated with early treatment failure within 12 months after the end of treatment in advanced stage HL independently from known clinical factors such as age or IPS.
authors.affiliation: Department of Internal Medicine I, University Hospital of Cologne, Cologne, Germany.
authors.forename: Roger
authors.initials: R
authors.lastname: Rautert
authors.forename: Timo
authors.initials: T
authors.lastname: Schinköthe
authors.forename: Jeremy
authors.initials: J
authors.lastname: Franklin
authors.forename: Martin
authors.initials: M
authors.lastname: Weihrauch
authors.forename: Boris
authors.initials: B
authors.lastname: Boll
authors.forename: Elke
authors.initials: E
authors.lastname: Pogge
authors.forename: Henning
authors.initials: H
authors.lastname: Bredenfeld
authors.forename: Andreas
authors.initials: A
authors.lastname: Engert
authors.forename: Volker
authors.initials: V
authors.lastname: Diehl
authors.forename: Daniel
authors.initials: D
authors.lastname: Re
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D018925:Chemokines / Q000097:blood; D016207:Cytokines / Q000097:blood; D005260:Female; D006689:Hodgkin Disease / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D016753:Interleukin-10 / Q000097:blood* / Q000276:immunology / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D017211:Treatment Failure
chemical_list: D018925:Chemokines; D016207:Cytokines; D016753:Interleukin-10