title: [Farnesol as a quorum-sensing molecule in Candida albicans].
abstract: Farnesol is one of the quorum sensing molecules of Candida albicans. In this report, we discuss the effects of farnesol on: 1. growth of Candida albicans in vitro and in vivo; 2. the incorporation of biomolecules into the cell wall of Candida albicans; and 3. cytokine expression by the immune system. Our results indicate genes of Candida albicans expressed at an early stage of quorum-sensing. Half of these genes are known and two-thirds of known genes are up-regulated by two types of transcription factors.
authors.affiliation: Section of Infection Biology, Department of Functional Bioscience, Fukuoka Dental College, Fukuoka, Japan.
authors.forename: Tamaki
authors.initials: T
authors.lastname: Cho
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Aoyama
authors.forename: Mika
authors.initials: M
authors.lastname: Toyoda
authors.forename: Hironobu
authors.initials: H
authors.lastname: Nakayama
authors.forename: Hiroji
authors.initials: H
authors.lastname: Chibana
authors.forename: Hidenori
authors.initials: H
authors.lastname: Kaminishi
authors.forename: Richard A
authors.initials: RA
authors.lastname: Calderone
mesh_terms: D002176:Candida albicans / Q000254:growth & development*; D005204:Farnesol / Q000494:pharmacology*; D053038:Quorum Sensing / Q000502:physiology*
chemical_list: D005204:Farnesol