title: mRNA expression of lysyl oxidase and matrix metalloproteinase-12 in mouse skin.
abstract: Elastic fibers in the dermis play an important role in skin elasticity. The desmosine crosslinking structure constructed of lysyl oxidase (LOX) in elastic fibers contributes to elasticity, while elastic fibers are primarily degraded by one of the matrix metalloproteinases (MMPs), MMP-12. We investigated the gender differences and diurnal variation of these enzymes. Gender-based differences in LOX mRNA expression were detected, and were significantly lower in females. In contrast, higher MMP-12 mRNA expression was observed in the light period, suggesting that elastic fibers might be degraded in the light rather than the dark period.
authors.affiliation: Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuaka-shi, Japan.
authors.forename: Yurika
authors.initials: Y
authors.lastname: Mizobe
authors.forename: Daichi
authors.initials: D
authors.lastname: Oikawa
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Tsuyama
authors.forename: Yoriko
authors.initials: Y
authors.lastname: Akimoto
authors.forename: Kousuke
authors.initials: K
authors.lastname: Hamasu
authors.forename: Eiichiro
authors.initials: E
authors.lastname: Onitsuka
authors.forename: Mikako
authors.initials: M
authors.lastname: Sato
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Takahata
authors.forename: Fumiki
authors.initials: F
authors.lastname: Morimatsu
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Furuse
mesh_terms: D000818:Animals; D002940:Circadian Rhythm / Q000235:genetics; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D008297:Male; D053508:Matrix Metalloproteinase 12 / Q000235:genetics*; D051379:Mice; D008249:Protein-Lysine 6-Oxidase / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012727:Sex Characteristics; D012867:Skin / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D008249:Protein-Lysine 6-Oxidase; D053508:Matrix Metalloproteinase 12