title: Validation of an extended method for the detection of the misuse of endogenous steroids in sports, including new hydroxylated metabolites.
abstract: Endogenous steroids are amongst the most misused doping agents in sports. Their presence poses a major challenge for doping control laboratories. Current threshold levels do not allow for the detection of all endogenous steroid misuse due to great interindividual variations in urinary steroid concentrations. A method has been developed and validated to screen for traditionally monitored endogenous steroids in doping control as well as specific hydroxylated/oxygenated metabolites in order to enhance the detection capabilities for the misuse of endogenous steroids.
authors.affiliation: DoCoLab - UGent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, 9052 Zwijnaarde, Belgium. Pieter.VanRenterghem@Ugentb.be
authors.forename: P
authors.initials: P
authors.lastname: Van Renterghem
authors.forename: P
authors.initials: P
authors.lastname: Van Eenoo
authors.forename: W
authors.initials: W
authors.lastname: Van Thuyne
authors.forename: H
authors.initials: H
authors.lastname: Geyer
authors.forename: W
authors.initials: W
authors.lastname: Schänzer
authors.forename: F T
authors.initials: FT
authors.lastname: Delbeke
mesh_terms: D005591:Chemical Fractionation; D002849:Chromatography, Gas; D004300:Doping in Sports; D006801:Humans; D006868:Hydrolysis; D015203:Reproducibility of Results; D013256:Steroids / Q000378:metabolism* / Q000652:urine*; D015813:Substance Abuse Detection / Q000379:methods*
chemical_list: D013256:Steroids