Lipids on the move: simulations of membrane pores, domains, stalks and curves.
In this review we describe the state-of-the-art of computer simulation studies of lipid membranes. We focus on collective lipid-lipid and lipid-protein interactions that trigger deformations of the natural lamellar membrane state, showing that many important biological processes including self-aggregation of membrane components into domains, the formation of non-lamellar phases, and membrane poration and curving, are now amenable to detailed simulation studies.
Marrink
Siewert J
SJ
Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands. s.j.marrink@rug.nl
de Vries
Alex H
AH
Tieleman
D Peter
DP
D000818:Animals; D022082:Cellular Structures / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D003198:Computer Simulation; D004734:Energy Metabolism; D006801:Humans; D008560:Membrane Fluidity; D008563:Membrane Lipids / Q000378:metabolism* / Q000502:physiology*; D021962:Membrane Microdomains / Q000378:metabolism* / Q000502:physiology; D008954:Models, Biological; D008958:Models, Molecular
D008563:Membrane Lipids