title: The combination of docetaxel and cisplatin plus fluorouracil as neoadjuvant chemotherapy in the treatment of T4 stage gastric cancer.
abstract: The prognosis of local advanced gastric carcinoma is very poor. We evaluated the impact on survival and the effects induced by the triple combination docetaxel-cisplatin-fluorouracil (DCF) as neoadjuvant chemotherapy in 24 T4 stage gastric tumor patients. They received 2-3 cycles DCF chemotherapy, followed by radical gastric resection. Tumor downstaging detected by CT was obtained in 17 out of 24 patients. The overall 3-year survival rate was 68.2%. Patients who received R0 resection (19/22) showed a 3-year survival rate of 78.9%. T downstaged patients (17/22) showed a higher 3-year survival rate of 82.4%. Those who responded to the triple combination of docetaxel-cisplatin-fluorouracil, exhibited T downstaging and subsequently received an R0 resection had a definitely better chance of a cure as compared to surgery alone, according to a complete 3-year follow-up.
authors.affiliation: Department of Surgery, The Six People's Hospital of Shanghai, Shanghai Jiaotong University, Yishan Road 600, Shanghai 200233, PR China.
authors.forename: Ming-Gao
authors.initials: MG
authors.lastname: Guo
authors.forename: Qi
authors.initials: Q
authors.lastname: Zheng
authors.forename: Zhe
authors.initials: Z
authors.lastname: Cheng
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Chang-Ning
authors.initials: CN
authors.lastname: Feng
authors.forename: Zhe
authors.initials: Z
authors.lastname: Yang
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D000328:Adult; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002681:China; D002945:Cisplatin / Q000008:administration & dosage*; D000077143:Docetaxel; D004384:Duodenoscopy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D005743:Gastrectomy; D005773:Gastroscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D043823:Taxoids / Q000008:administration & dosage*
chemical_list: D000964:Antimetabolites, Antineoplastic; D043823:Taxoids; D000077143:Docetaxel; D002945:Cisplatin; D005472:Fluorouracil