title: Measuring HCV infectivity produced in cell culture and in vivo.
abstract: Recently described systems for efficiently growing HCV in cell culture provide powerful new tools with which to dissect the life cycle of this important human pathogen. This chapter describes methods for measuring the infectivity of HCV produced in cell culture or recovered from animals experimentally infected with the cell culture-produced virus.
authors.affiliation: Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Brett D
authors.initials: BD
authors.lastname: Lindenbach
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques; D045744:Cell Line, Tumor; D023381:Endpoint Determination; D016174:Hepacivirus / Q000254:growth & development* / Q000472:pathogenicity*; D006801:Humans; D012692:Serial Passage; D014774:Virulence; D014776:Virus Cultivation / Q000379:methods*