Anthropomorphic measurements and event-free survival in patients with favorable histology Wilms tumor: a report from the Children's Oncology Group.
OBJECTIVE
We retrospectively examined the effect of body weight and body mass index (BMI) on event-free survival (EFS) of children with Wilms tumor treated on National Wilms Tumor Study-5 (NWTS-5).


METHODS
Eligible study participants: stages I-IV favorable histology Wilms tumor with immediate nephrectomy; height and weight recorded at diagnosis, and loss of heterozygosity for chromosomes 1p and 16q assessed.


RESULTS
A total of 1,532 patients were included in the analysis. The median follow-up was 4.9 years. 493 patients were less than 2 years of age and 1039 were 2 years of age or older. In both age groups there were more patients than expected with a weight or body mass index (BMI) less than the 10 per thousand or greater than the 90 per thousand. There was no relationship of weight-for-age or BMI-for-age and EFS in univariate analyses (P = 0.28, log-rank test for both comparisons). A Cox proportional hazards model, stratified by risk/treatment groups, showed that, among patients less than 2 years of age, low or high weight-for-age was not predictive of EFS (P = 0.16). Similarly, a Cox proportional hazards model, stratified by risk/treatment groups, showed that among patients greater than 2 years of age, low or high body mass index for age was not predictive of EFS (P = 0.58).


CONCLUSIONS
There was no evidence that anthropomorphic data obtained at diagnosis for patients with favorable histology stages I-IV Wilms tumor was predictive for EFS in the setting of current treatment regimens. There were more patients with lower or higher weight/BMI than expected.
Fernandez
Conrad V
CV
IWK Health Centre, Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada. conrad.fernandez@iwk.nshealth.ca
Anderson
James
J
Breslow
Norman E
NE
Dome
Jeffrey S
JS
Grundy
P E
PE
Perlman
Elizabeth J
EJ
Green
Daniel M
DM
D000367:Age Factors; D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D002878:Chromosomes, Human, Pair 1; D002885:Chromosomes, Human, Pair 16; D018572:Disease-Free Survival; D006801:Humans; D007223:Infant; D019656:Loss of Heterozygosity; D009392:Nephrectomy; D011379:Prognosis; D011446:Prospective Studies; D009396:Wilms Tumor / Q000235:genetics / Q000401:mortality* / Q000473:pathology*