Tract-by-tract morphometric and diffusivity analyses in vivo of spinocerebellar degeneration.
OBJECTIVE
Three-dimensional anisotropy contrast (3DAC) based on a periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) sequence on a 3.0 T system is a new magnetic resonance imaging technique capable of providing images with significantly high anatomical resolution. The purpose of this study was to confirm whether this technique can characterize the degenerative processes in the brainstem of patients with spinocerebellar degeneration (SCD).


METHODS
3DAC images of 13 patients with multiple system atrophy with predominant cerebellar symptoms (MSA-C) and seven International Cooperative Ataxia Rating Scale (ICARS) score-matched patients with Machado-Joseph disease (MJD) were created using a diffusion-weighted PROPELLER sequence on a 3.0T system. The section of the middle pons was chosen for morphometric and diffusivity analyses.


RESULTS
The above analyses showed that atrophy and increased diffusivity of the ventral portion of the pons indicated MSA-C, whereas atrophy and increased diffusivity of the pontine tegmentum indicated MJD. Furthermore, ICARS scores significantly correlated with both the severities of the pontine atrophy and the mean diffusivity values of the ventral pontocerebellar tracts.


CONCLUSIONS
This study demonstrated that 3DAC PROPELLER on a 3.0T system enables in vivo "tract by tract" quantitative analysis of pontine degeneration in SCD.
Terajima
Kenshi
K
Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Niigata, Japan. terajima@bri.niigata-u.ac.jp
Matsuzawa
Hitoshi
H
Shimohata
Takayoshi
T
Akazawa
Kouhei
K
Nishizawa
Masatoyo
M
Nakada
Tsutomu
T
D000328:Adult; D016880:Anisotropy; D002531:Cerebellum / Q000473:pathology; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D017827:Machado-Joseph Disease / Q000473:pathology; D008297:Male; D008636:Mesencephalon / Q000473:pathology; D008875:Middle Aged; D009434:Neural Pathways / Q000473:pathology; D011149:Pons / Q000473:pathology*; D011712:Pyramidal Tracts / Q000473:pathology; D012720:Severity of Illness Index; D013132:Spinocerebellar Degenerations / Q000473:pathology*