Protein tyrosine nitration--an update.
Tyrosine nitration is a covalent post-translational protein modification derived from the reaction of proteins with nitrating agents. Tyrosine nitration has been used as a marker of oxidant burden in human diseases. However, it remains unclear whether protein nitration is responsible for alterations in protein function that imparts an increased risk for disease development or unfavorable outcomes. Emerging data implicate tyrosine nitration as a mediator of immune responses suggesting a novel biological function for this protein modification.
Ischiropoulos
Harry
H
Stokes Research Institute and Departments of Pediatrics and Pharmacology, Children's Hospital of Philadelphia and The University of Pennsylvania, 417 Abramson Research Center, Philadelphia, PA 19104-4318, USA. ischirop@mail.med.upenn.edu
D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis; D009566:Nitrates / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism; D015538:Nitrosation; D010636:Phenols / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism; D014443:Tyrosine / Q000378:metabolism*
D007136:Immunoglobulins; D009566:Nitrates; D010636:Phenols; D011506:Proteins; D009569:Nitric Oxide; D014443:Tyrosine; D013482:Superoxide Dismutase