title: Indoleamine 2,3-dioxygenase in infection: the paradox of an evasive strategy that benefits the host.
abstract: Initially recognized in infection because of antimicrobial activity ('tryptophan starvation'), indoleamine 2,3-dioxygenase (IDO) is widely involved in host immune homeostasis and even immune evasion by microbes that establish commensalism or chronic infection. This review deals with recent findings that could gain IDO a reputation of Jack-of-all-trades in mammalian host/microbe interactions.
authors.affiliation: Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy. metzelante@hotmail.com
authors.forename: Teresa
authors.initials: T
authors.lastname: Zelante
authors.forename: Francesca
authors.initials: F
authors.lastname: Fallarino
authors.forename: Francesco
authors.initials: F
authors.lastname: Bistoni
authors.forename: Paolo
authors.initials: P
authors.lastname: Puccetti
authors.forename: Luigina
authors.initials: L
authors.lastname: Romani
mesh_terms: D000818:Animals; D005658:Fungi / Q000201:enzymology* / Q000235:genetics; D054884:Host-Pathogen Interactions; D006801:Humans; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000235:genetics / Q000378:metabolism*; D007737:Kynurenine / Q000378:metabolism; D051379:Mice; D009181:Mycoses / Q000276:immunology* / Q000382:microbiology; D014364:Tryptophan / Q000378:metabolism
chemical_list: D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D007737:Kynurenine; D014364:Tryptophan