title: N-Acylhomoserine lactone-mediated quorum sensing: a twist in the tail and a blow for host immunity.
abstract: Communication through quorum sensing (QS) enables bacterial populations to coordinate their behavior. Recent work on N-acylhomoserine lactone-mediated QS has revealed that some soil bacteria exploit host-derived substrates to generate an alternative N-substituted homoserine lactone. New light has also been shed on the mechanism by which N-(3-oxo-dodecanoyl)-L-homoserine lactone modulates host inflammatory signaling pathways to promote bacterial survival.
authors.affiliation: Menzies Research Institute and School of Medicine, University of Tasmania, Hobart, TAS 7001, Australia.
authors.forename: Margaret
authors.initials: M
authors.lastname: Cooley
authors.forename: Siri Ram
authors.initials: SR
authors.lastname: Chhabra
authors.forename: Paul
authors.initials: P
authors.lastname: Williams
mesh_terms: D054742:Acyl-Butyrolactones / Q000378:metabolism*; D000818:Animals; D001419:Bacteria / Q000166:cytology / Q000378:metabolism; D018407:Bacterial Physiological Phenomena; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D007109:Immunity; D053038:Quorum Sensing
chemical_list: D054742:Acyl-Butyrolactones