Adipokines and insulin resistance.
Obesity is associated with an array of health problems in adult and pediatric populations. Understanding the pathogenesis of obesity and its metabolic sequelae has advanced rapidly over the past decades. Adipose tissue represents an active endocrine organ that, in addition to regulating fat mass and nutrient homeostasis, releases a large number of bioactive mediators (adipokines) that signal to organs of metabolic importance including brain, liver, skeletal muscle, and the immune system--thereby modulating hemostasis, blood pressure, lipid and glucose metabolism, inflammation, and atherosclerosis. In the present review, we summarize current data on the effect of the adipose tissue-derived hormones adiponectin, chemerin, leptin, omentin, resistin, retinol binding protein 4, tumor necrosis factor-alpha and interleukin-6, vaspin, and visfatin on insulin resistance.
Rabe
Katja
K
Department of Internal Medicine II, University of Munich, Munich, Germany.
Lehrke
Michael
M
Parhofer
Klaus G
KG
Broedl
Uli C
UC
D054392:Adipokines / Q000378:metabolism* / Q000502:physiology*; D000818:Animals; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D015850:Interleukin-6 / Q000378:metabolism / Q000502:physiology; D020738:Leptin / Q000378:metabolism / Q000502:physiology; D054409:Nicotinamide Phosphoribosyltransferase / Q000378:metabolism / Q000502:physiology; D052243:Resistin / Q000378:metabolism / Q000502:physiology; D054839:Retinol-Binding Proteins, Plasma / Q000378:metabolism / Q000502:physiology
D054392:Adipokines; D015850:Interleukin-6; D020738:Leptin; D052243:Resistin; D054839:Retinol-Binding Proteins, Plasma; D054409:Nicotinamide Phosphoribosyltransferase