Posterior cortical atrophy: a rare form of dementia with in vivo evidence of amyloid-beta accumulation.
Posterior cortical atrophy (PCA) is a rare form of degenerative dementia, which is characterized by progressive atrophy of occipital and parietal cortical areas. It usually manifests as increasing difficulties of visuoperceptive abilities. Later on, memory and other cognitive functions are involved. Various pathologies have been associated with clinical PCA presentation, but most of the patients with autopsy have had Alzheimer-type pathology. Thus, PCA has been considered to be a rare form of Alzheimer-type dementia with unusual pathological distribution. Here we describe a patient who had a typical clinical course for this syndrome and who showed a positive accumulation of amyloid-beta in posterior areas studied with positron emission tomography.
Tenovuo
Olli
O
Department of Neurology, University of Turku, Turku, Finland.
Kemppainen
Nina
N
Aalto
Sargo
S
Någren
Kjell
K
Rinne
Juha O
JO
D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000814:Aniline Compounds; D001284:Atrophy; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D003704:Dementia / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D008024:Ligands; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D013844:Thiazoles; D014786:Vision Disorders / Q000209:etiology / Q000473:pathology; D014796:Visual Perception / Q000502:physiology
C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D016229:Amyloid beta-Peptides; D000814:Aniline Compounds; D008024:Ligands; D013844:Thiazoles