[Preparation of self-microemulsifying soft capsule and investigation of dissolution for Duyiwei].
OBJECTIVE
To prepare the self-microemulsifying soft capsule (SMESC) of Duyiwei and investigate its dissolution property.


METHODS
Through solubility experiment, self-microemulsification in vitro, drawing phase diagram and investigating the stability of solution, the optimum formulation was determined for Duyiwei. The dissolution of SMESC was measured, taking the commercial capsule as reference.


RESULTS
In the optimum formulation, Labrasol, Transcutol P and ethyl oleate were screened as emulsifier, co-emulsifier and oil phase, respectively. The optimized proportion was 60: 25: 15. The dissolution of SMESC in water was more than 85% in 10 minutes, while that of the commercial capsule was less than 50% in 60 minutes.


CONCLUSIONS
In comparison with the commercial capsule, the dissolution of SMESC is sufficiently improved in water.
Cui
Sheng-Miao
SM
Guangdong Pharmaceutical University, Guangzhou 510006, China.
Shen
Xue-Mei
XM
D002214:Capsules; D004339:Drug Compounding; D016503:Drug Delivery Systems; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry*; D004655:Emulsions; D019686:Lamiaceae / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D012995:Solubility; D013501:Surface-Active Agents; D013678:Technology, Pharmaceutical / Q000379:methods*
D002214:Capsules; D004365:Drugs, Chinese Herbal; D004655:Emulsions; D013501:Surface-Active Agents