Type 1 diabetes and idiopathic retroperitoneal fibrosis: case report.
Retroperitoneal fibrosis is characterized by the presence of a retroperitoneal tissue, consisting of chronic inflammation and marked fibrosis, which entraps the retroperitoneal organs. In two-thirds of cases, the retroperitoneal fibrosis is idiopathic. The pathogenic mechanism is not clearly identified. We report a case of idiopathic retroperitoneal fibrosis associated with type 1 diabetes mellitus. A 61-year-old woman with C peptide negative insulindependent diabetes developed retroperitoneal fibrosis revealed by bilateral hydronephrosis. Anti-GAD 65 antibodies were positive. There were no signs of autoimmune pancreatitis: no steatorrhea, normal IgG4 isotype levels, and absence of pancreas morphological abnormalities.
Sum
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Pôle NUDE, service d'endocrinologie, diabète et maladies métaboliques, hôpitaux universitaires de Strasbourg, 67091 Strasbourg cedex, France.
Moreau
F
F
Jacquemin
D
D
Neuville
A
A
Jeung
M
M
Pinget
M
M
Chenard
M-P
MP
Kessler
L
L
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002096:C-Peptide / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D005968:Glutamate Decarboxylase / Q000276:immunology / Q000378:metabolism; D006801:Humans; D006869:Hydronephrosis / Q000150:complications / Q000473:pathology; D008875:Middle Aged; D012185:Retroperitoneal Fibrosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D012187:Retroperitoneal Space / Q000000981:diagnostic imaging / Q000473:pathology; D013256:Steroids / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D014513:Ureter / Q000473:pathology
D000893:Anti-Inflammatory Agents; D002096:C-Peptide; D013256:Steroids; D005968:Glutamate Decarboxylase; C401141:glutamate decarboxylase 2