title: Association of nonsynonymous substitutions in the intermediate region of the vacA gene of Helicobacter pylori with gastric diseases in Taiwan.
abstract: The amino acid sequences corresponding to the vacA intermediate region from 39 isolates of Helicobacter pylori were investigated. The substitution of a G for the third S in the i1-type cluster B sequence (QASEGITSSK) conferred a greater risk of gastric diseases (P < 0.03; Fisher's exact test). The conserved substitutions of an F for the Y in the cluster A sequence and of an M for the second N in the i1-type cluster C sequence could be a marker of VacA in the Taiwanese strains.
authors.affiliation: Institutes of Basic Medical Sciences, National Cheng Kung University, College of Medicine, No. 1, University Road, Tainan 701, Taiwan.
authors.forename: Shew-Meei
authors.initials: SM
authors.lastname: Sheu
authors.forename: Kuei-Hsiang
authors.initials: KH
authors.lastname: Hung
authors.forename: Bor-Shyang
authors.initials: BS
authors.lastname: Sheu
authors.forename: Hsiao-Bai
authors.initials: HB
authors.lastname: Yang
authors.forename: Jiunn-Jong
authors.initials: JJ
authors.lastname: Wu
mesh_terms: D000328:Adult; D019943:Amino Acid Substitution / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics*; D004269:DNA, Bacterial / Q000235:genetics; D005260:Female; D005838:Genotype; D016481:Helicobacter Infections / Q000382:microbiology* / Q000473:pathology*; D016480:Helicobacter pylori / Q000235:genetics* / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D020125:Mutation, Missense; D017422:Sequence Analysis, DNA; D013624:Taiwan
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial; C074689:VacA protein, Helicobacter pylori