Transient myeloproliferation mimicking JMML associated with parvovirus infection of infancy.
We report a 2-month-old infant with Parvovirus B19 infection presenting as transient myeloproliferation resembling juvenile myelomonocytic leukemia (JMML). Patient history, physical examination, and laboratory findings were suggestive of JMML. On viral serology, raised IgM and IgG titers for Parvovirus B19 infection were found in the absence of giant proerythroblasts and viral inclusions in the erythroid precursors. Follow-up showing a decrease in viral titers suggested parvovirus infection as an etiological factor for the development of myeloproliferative features. This case highlights the importance of viral serology in work-up myeloproliferative disorders of infancy and childhood.
Gupta
Nidhi
N
Laboratory Oncology Unit, Dr B R Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India. drritugupta@gmail.com
Gupta
Ritu
R
Bakhshi
Sameer
S
D005260:Female; D006801:Humans; D007223:Infant; D054429:Leukemia, Myelomonocytic, Juvenile / Q000150:complications* / Q000473:pathology*; D010322:Parvoviridae Infections / Q000150:complications*; D016732:Parvovirus B19, Human / Q000502:physiology*