Tulasnein and podospirone from the coprophilous xylariaceous fungus Podosordaria tulasnei.
Tulasnein (1), a new metabolite with strong antimicrobial and weaker cytotoxic and phytotoxic activity, was isolated from culture filtrates of three strains of the xylariaceous coprophilous fungus Podosordaria tulasnei. The producing strains were identified by their rhizomorphs and by ITS rDNA sequence analysis. A second new metabolite, podospirone (2), was also produced by all three strains whereas the weakly cytotoxic (+)-3,4-anhydroshikimic acid methyl ester (3) was detected in only one strain.
Ridderbusch
Daniela C
DC
Department of Biotechnology, University of Kaiserslautern, Kaiserslautern, Germany.
Weber
Roland W S
RW
Anke
Timm
T
Sterner
Olov
O
D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D005243:Feces / Q000382:microbiology; D005658:Fungi / Q000187:drug effects*; D006801:Humans; D029686:Lepidium / Q000187:drug effects; D007939:Leukemia L1210; D051379:Mice; D008826:Microbial Sensitivity Tests; D011817:Rabbits; D020037:Sordariales / Q000737:chemistry* / Q000254:growth & development / Q000302:isolation & purification; D016339:Spectrometry, Mass, Fast Atom Bombardment
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents