title: Microbial transformation of alantolactone by Mucor polymorphosporus.
abstract: Two new transformed sesquiterpenes of alantolactone by Mucor polymorphosporus were obtained. They were characterized as 3beta-hydroxy-11betaH-eudesm-5-en-8beta,12-olide (2) and 3beta,11alpha-dihydroxy-eudesm-5-en-8beta,12-olide (3), on the basis of spectral methods including 2D NMR. And product 3 was an unusual hydroxylation derivative of alantolactone at C-11.
authors.affiliation: The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.
authors.forename: Xiu-Lan
authors.initials: XL
authors.lastname: Xin
authors.forename: Xiao-Chi
authors.initials: XC
authors.lastname: Ma
authors.forename: Ke-Xin
authors.initials: KX
authors.lastname: Liu
authors.forename: Jian
authors.initials: J
authors.lastname: Han
authors.forename: Bao-Rong
authors.initials: BR
authors.lastname: Wang
authors.forename: De-An
authors.initials: DA
authors.lastname: Guo
mesh_terms: D007783:Lactones / Q000737:chemistry* / Q000378:metabolism*; D015394:Molecular Structure; D009089:Mucor / Q000378:metabolism*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000378:metabolism*; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry* / Q000378:metabolism*
chemical_list: C539060:3beta,11alpha-dihydroxy-eudesm-5-en-8beta,12-olide; C539059:3beta-hydroxy-11betaH-eudesm-5-en-8beta,12-olide; D007783:Lactones; D012717:Sesquiterpenes; D045787:Sesquiterpenes, Eudesmane; C004363:alantolactone