title: Identification of genes targeted by microRNAs.
abstract: miRNAs (microRNAs) are recently discovered regulators of gene expression. They target mRNAs that contain partially complementary sites to the miRNA. The level of complementarity is different between target site-miRNA pairs, and finding target genes has proved to be a bigger challenge than expected. The present paper reviews the different approaches to predict and experimentally identify genes targeted by miRNAs.
authors.affiliation: School of Biological Sciences, University of East Anglia, Norwich, UK. t.dalmay@uea.ac.uk
authors.forename: Tamas
authors.initials: T
authors.lastname: Dalmay
mesh_terms: D000818:Animals; D015536:Down-Regulation / Q000235:genetics; D005796:Genes; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D034743:RNA-Induced Silencing Complex / Q000378:metabolism
chemical_list: D035683:MicroRNAs; D034743:RNA-Induced Silencing Complex