title: Sibling and parental history in type 2 diabetes risk among ethnic Chinese: the Chin-Shan Community Cardiovascular Cohort Study.
abstract: BACKGROUND
  This study aims to compare various family history profiles as predictors of diabetes in a community-based prospective cohort because few prospective studies have examined the association of family history with diabetes risk in ethnic Chinese populations.
  
  
  METHODS
  Among 2960 participants free from baseline diabetes through the Chin-Shan Community Cardiovascular Cohort Study, there were 548 cases that developed diabetes after a median 9 years of follow-up.
  
  
  RESULTS
  After multivariate adjustment, sibling history was associated with diabetes [Relative risk (RR): 2.08, 95% confidence interval (CI): 1.42-3.06, P=0.0002]. Both maternal and paternal histories had similar effects (RR: 1.62, 95% CI: 1.04-2.51 for paternal history, RR: 1.36, 95% CI: 0.98-1.89 for maternal history). Obese participants with sibling history increased the risk of diabetes by 4.6-fold (RR: 4.61, 95% CI: 2.93-7.26), compared with those with neither obesity nor family history.
  
  
  CONCLUSIONS
  The findings support the hypothesis that sibling history is more important than parental history for diabetes risk.
authors.affiliation: Institute of Preventive Medicine, College of Public Health, National Taiwan University, Department of cInternal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Kuo-Liong
authors.initials: KL
authors.lastname: Chien
authors.forename: Hsiu-Ching
authors.initials: HC
authors.lastname: Hsu
authors.forename: Ta-Chen
authors.initials: TC
authors.lastname: Su
authors.forename: Wei-Tien
authors.initials: WT
authors.lastname: Chang
authors.forename: Pei-Chun
authors.initials: PC
authors.lastname: Chen
authors.forename: Ming-Fong
authors.initials: MF
authors.lastname: Chen
authors.forename: Yuan-Teh
authors.initials: YT
authors.lastname: Lee
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D044466:Asian People / Q000235:genetics*; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology / Q000209:etiology* / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000208:ethnology; D010290:Parents; D010375:Pedigree; D016016:Proportional Hazards Models; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D035781:Siblings