title: Night/day ratio as predictor of preeclampsia in normoalbuminuric, diabetic women: early signs of blood pressure disorders.
abstract: OBJECTIVE
  Day/night ratio from diurnal ambulatory blood pressure (AMBP) in pregnant women with type 1 diabetes mellitus (T1DM) and in non-diabetic women was evaluated for its association with preeclampsia, retinopathy, HbA1c, and birth weight.
  
  
  METHODS
  One hundred and sixty-one women were recruited for AMBP performed with a Spacelab 90207 monitor. The pregnant women were 50 non-diabetic women and 111 T1DM women with normoalbuminuria and no hypertension. ANOVA, regression, and ROC curves analysis were applied.
  
  
  RESULTS
  Women with simplex retinopathy had higher night/day ratio and lower birth weight than those without retinopathy. Women who developed preeclampsia had night/day ratio similar to those with simplex retinopathy. In first trimester they had higher blood pressure than those who did not develop preeclampsia.
  
  
  CONCLUSIONS
  Simplex retinopathy and preeclampsia are associated with a reduced night/day ratio even with normal blood pressure but night/day ratio provides no better prediction of preeclampsia than the absolute values.
authors.affiliation: Department of Obstetrics/Gynecology, Herning Hospital, Aarhus University Hospital, Denmark. affl@ringamt.dk
authors.forename: Finn Friis
authors.initials: FF
authors.lastname: Lauszus
authors.forename: Anni
authors.initials: A
authors.lastname: Rosgaard
authors.forename: Thea
authors.initials: T
authors.lastname: Lousen
authors.forename: Ole W
authors.initials: OW
authors.lastname: Rasmussen
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Klebe
authors.forename: Joachim G
authors.initials: JG
authors.lastname: Klebe
mesh_terms: D000328:Adult; D001794:Blood Pressure; D002940:Circadian Rhythm; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D003930:Diabetic Retinopathy / Q000503:physiopathology; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000503:physiopathology*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000503:physiopathology*; D055815:Young Adult