The synthesis and biological evaluation of 10-O-dialkylaminoethyl ginkgolide B as platelet-activating factor antagonist.
Four nitrogen-containing derivatives of ginkgolide B were synthesized to improve the physical-chemical properties and bioavailability of ginkgolide B. The reaction was accomplished with the nitrogen atom as neighboring group participating in the replacement reaction. All of the four compounds were proved to have excellent inhibiting effect on rabbit platelet aggregation induced by platelet-activating factor which is as well as ginkgolide B.
Guo
Chun-Jun
CJ
Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, China.
Ren
Yi
Y
Qin
Yin-Lin
YL
Zhang
Qian
Q
D000818:Animals; D046934:Ginkgolides / Q000138:chemical synthesis* / Q000494:pharmacology*; D015394:Molecular Structure; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011817:Rabbits
D046934:Ginkgolides; D010972:Platelet Activating Factor; D010975:Platelet Aggregation Inhibitors