Hypomagnesemia and mortality in patients with type 2 diabetes.
To evaluate if hypomagnesemia, at the time of admission in the Intensive care Unit (ICU), is associated with a higher mortality in critically ill patients with type 2 diabetes. Fourteen consecutive critically ill patients with type 2 diabetes admitted in the ICU of a teaching General Hospital serving an inner city population were enrolled in a follow-up study. Parenteral or enteral nutritional support, surgical procedures, malignancy, traumatism or physical injury, pulmonary and/or cardiovascular diseases, chronic renal failure, hepatic cirrhosis, cerebrovascular disease, and disorders of the thyroid gland, were exclusion criteria. Hypomagnesemia was defined by serum magnesium levels < 0.66 mmol/L (1.6 mg/dL). At the time of admission in the ICU, 10 (71.4%) individuals had hypomagnesemia. Mortality rates in the hypomagnesemic and normomagnesemic individuals were 80 and 25%, respectively. Serum magnesium levels were significantly lower in the subjects who died (0.51 [0.41, 0.62] mmol/L) compared with those who survived (0.85 [0.65, 1.11], mmol/L), p = 0.01. The logistic regression model adjusted by APACHE II score and hsCRP levels showed that hypomagnesemia is independently associated with mortality (OR 1.9, CI95% 1.2-14.7). Hypomagnesemia at the time of admission in the ICU seems to be associated with high mortality in critically ill patients with type 2 diabetes.
Curiel-García
José A
JA
General Hospital of the Mexican Social Security Institute at Durango, Av. Normal y Predio Canoas S/N; 34067, Durango, Dgo., Mexico.
Rodríguez-Morán
Martha
M
Guerrero-Romero
Fernando
F
D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000401:mortality; D005500:Follow-Up Studies; D006801:Humans; D007362:Intensive Care Units; D008274:Magnesium / Q000097:blood*; D008275:Magnesium Deficiency / Q000097:blood* / Q000401:mortality; D008875:Middle Aged
D008274:Magnesium