Renal insufficiency and anticancer drugs in elderly cancer patients: a subgroup analysis of the IRMA study.
The Renal Insufficiency and Anticancer Medications (IRMA) study is a French national, observational study which demonstrated the high prevalence of abnormal renal function in a population of 4684 solid tumor patients. Among them, 50-60% had decreased renal function, and 80% were treated with anticancer drugs that either necessitated dosage adjustment in case of renal insufficiency (RI) or were potentially nephrotoxic drugs. Since elderly patients are well-known to have reduced renal function, either due to physiological aging or their disease/medication history, a subgroup analysis of this particular population of patients was performed. In 1553 IRMA patients whose age was > or =65 years, the prevalence of RI was very high in spite of normal serum creatinine values in most cases. Anticancer drugs used may be nephrotoxic or need dosage adjustment in a high number of cases.
Launay-Vacher
Vincent
V
Department of Nephrology, Hôpital Pitié-Salpêtrière, Paris, France. vincent.launay-vacher@psl.aphp.fr
Spano
Jean-Philippe
JP
Janus
Nicolas
N
Gligorov
Joseph
J
Ray-Coquard
Isabelle
I
Oudard
Stéphane
S
Pourrat
Xavier
X
Morere
Jean-François
JF
Beuzeboc
Philippe
P
Deray
Gilbert
G
D000368:Aged; D000369:Aged, 80 and over; D016588:Anticarcinogenic Agents / Q000008:administration & dosage*; D003404:Creatinine / Q000097:blood; D005247:Feeding Behavior; D005260:Female; D005602:France / Q000453:epidemiology; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000150:complications* / Q000188:drug therapy; D015995:Prevalence; D051437:Renal Insufficiency / Q000150:complications* / Q000453:epidemiology* / Q000628:therapy; D012189:Retrospective Studies
D016588:Anticarcinogenic Agents; D006454:Hemoglobins; D003404:Creatinine