title: Predictive factors for pregnancy after intrauterine insemination (IUI): an analysis of 1038 cycles and a review of the literature.
abstract: OBJECTIVE
  To determine the predictive factors for pregnancy after IUI.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  A single university medical center.
  
  
  METHODS
  One thousand thirty-eight IUI cycles in 353 couples were studied between 2002 and 2005.
  
  
  METHODS
  Ovarian stimulation via SC injection of FSH or hMG was performed daily; IUI was then performed 36 hours after triggering ovulation if at least one follicle measuring >16 mm and an endometrial thickness of >7 mm (with triple-line development) were obtained.
  
  
  METHODS
  Clinical pregnancy rates were analyzed according to the woman's age, the type of infertility, the spermogram characteristics, the total motile spermatozoa (TMS) count, the E(2) level before hCG injection, and the number of mature follicles.
  
  
  RESULTS
  The couple with the best chance of pregnancy can be described as follows: an under 30 woman with cervical or anovulatory infertility and a man with a TMS >or=5 million spermatozoa. The "ideal" stimulation cycle enables the recruitment of two follicles measuring >16 mm with an E(2) concentration >500 pg/mL on the day of hCG administration. The best results are obtained when IUI is performed using a soft catheter.
  
  
  CONCLUSIONS
  This study enabled the characterization of many prognostic factors for pregnancy and particularly those for women at risk of multiple pregnancies after IUI.
authors.affiliation: Department of Gynecology, Obstetrics and Reproductive Medicine, Amiens University Medical Center, Amiens, France. merviel.philippe@chu-amiens.fr
authors.forename: Philippe
authors.initials: P
authors.lastname: Merviel
authors.forename: Marie Hélène
authors.initials: MH
authors.lastname: Heraud
authors.forename: Nadège
authors.initials: N
authors.lastname: Grenier
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Lourdel
authors.forename: Pierre
authors.initials: P
authors.lastname: Sanguinet
authors.forename: Henri
authors.initials: H
authors.lastname: Copin
mesh_terms: D000328:Adult; D000367:Age Factors; D015415:Biomarkers / Q000097:blood; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D004867:Equipment Design; D004958:Estradiol / Q000097:blood; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage; D006801:Humans; D007246:Infertility / Q000097:blood / Q000473:pathology / Q000628:therapy*; D007279:Injections, Subcutaneous; D007315:Insemination, Artificial / Q000295:instrumentation; D016015:Logistic Models; D008297:Male; D008596:Menotropins / Q000008:administration & dosage; D016017:Odds Ratio; D010062:Ovulation Induction; D011237:Predictive Value of Tests; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013076:Sperm Count; D013081:Sperm Motility; D013094:Spermatozoa / Q000473:pathology; D016896:Treatment Outcome; D014427:Twins
chemical_list: D015415:Biomarkers; D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female; D004958:Estradiol; D008596:Menotropins; D005640:Follicle Stimulating Hormone