Blood compatibility evaluation of elastic gelatin gel from salmon collagen.
Blood compatibility of a novel elastic gelatin gel (e-gel) from salmon collagen was evaluated. After a 10-min incubation of the e-gel with rat whole blood, there was a macroscopically small thrombus formation on the e-gel. Microscopic observation revealed that few platelets had adhered to the e-gel. Furthermore, the platelet adhesion rate was markedly lower on the e-gel compared to collagen-coated and fibrinogen-coated surfaces. Comparable results were obtained with re-crosslinked e-gel. In conclusion, the e-gel demonstrated good blood compatibility.
Nagai
Nobuhiro
N
Creative Research Initiative "Sousei" (CRIS), Hokkaido University, N21-W10, Kita-ku, Sapporo, Hokkaido 001-0021, Japan. nagai491@yahoo.co.jp
Kubota
Ryosuke
R
Okahashi
Ryohei
R
Munekata
Masanobu
M
D000818:Animals; D001792:Blood Platelets / Q000737:chemistry; D003094:Collagen / Q000737:chemistry*; D004548:Elasticity; D005340:Fibrinogen / Q000737:chemistry; D005780:Gelatin / Q000737:chemistry*; D005782:Gels; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D010973:Platelet Adhesiveness; D051381:Rats; D012474:Salmon; D013499:Surface Properties; D013927:Thrombosis / Q000378:metabolism; D023822:Tissue Engineering / Q000379:methods*
D005782:Gels; D005780:Gelatin; D005340:Fibrinogen; D003094:Collagen