How can genetic advances impact on experimental models of encapsulating peritoneal sclerosis?
In this review we discuss how animal models have contributed to the understanding of pathological pathways that may be involved in the development of encapsulating peritoneal sclerosis. We review the various interventional procedures that, so far, have ameliorated disease progression in animals. Reviewing advancements in molecular biology and genetic technologies, we discuss how future experimental models may impact our understanding of the pathogenesis and treatment of this rare but complex disease.
Summers
Angela M
AM
Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, United Kingdom. angela.summers@cmmc.nhs.uk
Hoff
Catherine M
CM
Topley
Nicholas
N
D032761:Animal Experimentation; D000818:Animals; D015314:Dialysis Solutions / Q000494:pharmacology; D020022:Genetic Predisposition to Disease; D015316:Genetic Therapy; D006801:Humans; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D010537:Peritoneum / Q000187:drug effects / Q000473:pathology*; D012598:Sclerosis / Q000235:genetics / Q000473:pathology / Q000628:therapy
D015314:Dialysis Solutions