title: Tomographic x-ray-guided three-dimensional diffuse optical tomography of osteoarthritis in the finger joints.
abstract: We describe a multimodality imaging approach that combines x-ray tomosynthesis with near-infrared diffuse optical tomography (DOT) for high-resolution imaging of osteoarthritis in the finger joints. In this approach, we take advantage of high resolution x-ray imaging particularly of the bones and incorporate the fine structural maps obtained from x ray as a priori information into DOT reconstructions. To realize this multi-modality approach, we constructed a hybrid imaging platform that integrated a C-arm-based x-ray tomosynthetic system with a multichannel optic-fiber-based DOT system. We also implemented improved hybrid regularization-based reconstruction algorithms that have shown to be especially effective for high-resolution modality-guided DOT. Initial evaluation of our x-ray-guided DOT reconstruction approach in the finger joints shows that spatial resolution of DOT can be enhanced dramatically when the three-dimensional geometry of bones is known a priori. In particular, the improved quantitative capability of imaging absorption and scattering coefficients of the joint tissues allows for more accurate diagnosis of osteoarthritis over x-ray radiography or DOT alone.
authors.affiliation: University of Florida, Department of Biomedical Engineering, Gainesville, Florida 32611-6131, USA.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yuan
authors.forename: Qizhi
authors.initials: Q
authors.lastname: Zhang
authors.forename: Eric S
authors.initials: ES
authors.lastname: Sobel
authors.forename: Huabei
authors.initials: H
authors.lastname: Jiang
mesh_terms: D000328:Adult; D001175:Arthrography / Q000379:methods; D005260:Female; D005384:Finger Joint / Q000000981:diagnostic imaging* / Q000473:pathology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000175:diagnosis*; D013382:Subtraction Technique; D041622:Tomography, Optical / Q000379:methods*