Human papillomavirus in HNSCC: a European epidemiologic perspective.
The aim of this study was to assess incidence and survival of human papillomavirus-related and unrelated head and neck squamous cell carcinoma sites from 15 European population-based cancer registries. This analysis was performed on 29,265 adult (aged approximately 15 years) cancer patients diagnosed in the period from 1988 to 2002. The human papillomavirus-unrelated cancer sites had an age-standardized incidence higher than the human papillomavirus-related cancer cases (3.8 versus 2.5/100,000 year). Incidence rates of head and neck squamous cell carcinomas increased more for human papillomavirus-related than unrelated cancer sites. Three-year survival rates improved more in human papillomavirus-related than unrelated cancer sites, and women had better rates of survival than men.
Licitra
Lisa
L
Head and Neck Medical Oncology Unit, Fondazione IRCCS, Istituto Nazionale dei Tumori, Via Venezian 1, 20133 Milan, Italy. lisa.licitra@istitutotumori.mi.it
Zigon
Giulia
G
Gatta
Gemma
G
Sánchez
Maria-José
MJ
Berrino
Franco
F
D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000628:therapy / Q000821:virology; D018572:Disease-Free Survival; D005060:Europe; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000628:therapy / Q000821:virology; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000401:mortality / Q000628:therapy / Q000635:transmission; D015996:Survival Rate