[Hepatoprotective effect of Gossipium hirsutum extract on acute experimental hepatitis on rat liver injury].
OBJECTIVE
To investigate the protective effect on the mice acute experimental hepatic injury by Flos Gossypium herbaceum extracts (FGF-I, FGF-II).


METHODS
Experimental hepatic injury model was established by a single intraperitoneal injection of 350 mg x kg(-1) D-CalN in Wistar rats. Serum samples for alanine aminotransferase (ALT), aspartate transferase (AST) level and liver homogenate samples for super oxide dismutase (SOD), malondialdehyde (MDA), Glutathione peroxidese (GSH-PX) activities were assayed.


RESULTS
For acute experimental hepatic injury, FGF-I and FGF-II significantly decrease the serum transaminase activities (P < 0.01). FGF-I increased the SOD activities (P < 0.01), and decreased MDA content only for 50 mg x kg(-1) FGF-I (P < 0.05), no effect on GSH-PX activity was found for them. FGF-II increased the SOD and GSH-PX activity (P < 0.05) with decreased MDA content (P < 0.05).


CONCLUSIONS
FGF-I and FGF-II showed significant protective action in mice experimental hepatic injury.
Batur
M
M
Department of Pharmacy, Xinjiang Medical University, Urumqi 830054, China.
Cheng
Lu-feng
LF
Yan
Dong
D
Parhat
K
K
D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004789:Enzyme Activation / Q000187:drug effects; D035264:Flowers / Q000737:chemistry*; D005979:Glutathione Peroxidase / Q000378:metabolism; D003368:Gossypium / Q000737:chemistry*; D006520:Hepatitis, Animal / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase