Occupational lead exposure effect on liver functions and biochemical parameters.
The effect of occupational lead exposure on the liver function and on the blood biochemical parameters among the battery workers and the muffler repair workers was studied. The study included 22 battery and 38 muffler repair workers. Whole blood lead levels were determined by atomic absorption spectrophotometers. Total protein, albumin, globulin, cholesterol, triglyceride, total bilirubin, aspartate transaminase (AST), alanine transaminase (ALT), gamma glutamyltransferase (GGT), lactate dehydrogenase (LDH), and alkaline phosphatase (ALP) levels were determined in the serum by spectrophotometry. The blood lead levels of the battery workers, muffler repair workers, and the controls were found to be 36.83 +/- 8.13 microg/dL, 26.99 +/- 9.42 microg/dL, and 14.81 +/- 3.01 microg/dL, respectively. Blood lead levels of the workers were significantly higher than those of controls (p < 0.001). The lead level of the battery workers was also significantly higher than that of muffler repair workers (p < 0.001). Although, statisticly significant, higher blood lead levels are not related to toxicity for battery and muffler repair workers. Total protein, globulin, cholesterol, LDH, and ALP levels were within normal levels, however, they were slightly higher than the control levels. Increased LDH among the workers seems to be related rather to other causes than to the liver injury.
Can
S
S
Department of Physiology, University of Ataturk, Erzurum, Turkey.
Bağci
C
C
Ozaslan
M
M
Bozkurt
Ai
A
Cengiz
B
B
Cakmak
E A
EA
Kocabaş
R
R
Karadağ
E
E
Tarakçioğlu
M
M
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000428:Alcohol Drinking / Q000453:epidemiology; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007854:Lead / Q000097:blood / Q000633:toxicity*; D008055:Lipids / Q000097:blood; D008107:Liver Diseases / Q000453:epidemiology / Q000378:metabolism; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D018986:Motor Vehicles; D009784:Occupational Diseases / Q000139:chemically induced* / Q000453:epidemiology / Q000378:metabolism; D016273:Occupational Exposure; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology; D055815:Young Adult; D005723:gamma-Glutamyltransferase / Q000097:blood
D008055:Lipids; D007854:Lead; D007770:L-Lactate Dehydrogenase; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin