title: Javanicin, an antibacterial naphthaquinone from an endophytic fungus of neem, Chloridium sp.
abstract: The endophytic fungus Chloridium sp. produces javanicin under liquid and solid media culture conditions. This highly functionalized naphthaquinone exhibits strong antibacterial activity against Pseudomonas spp., representing pathogens to both humans and plants. The compound was crystallized and the structure was elucidated by X-ray crystallography. The X-ray structure confirms the previously elucidated structure of the compound that was done under standard spectroscopic methods. The importance of javanicin in establishing symbiosis between Chloridium sp. and its host plant, Azadirachta indica, is briefly discussed.
authors.affiliation: Mycopathology and Microbial Technology Laboratory, Department of Botany, Banaras Hindu University, Varanasi 221005, India. rnkharwar@yahoo.com
authors.forename: Ravindra N
authors.initials: RN
authors.lastname: Kharwar
authors.forename: Vijay C
authors.initials: VC
authors.lastname: Verma
authors.forename: Anuj
authors.initials: A
authors.lastname: Kumar
authors.forename: Surendra K
authors.initials: SK
authors.lastname: Gond
authors.forename: James K
authors.initials: JK
authors.lastname: Harper
authors.forename: Wilford M
authors.initials: WM
authors.lastname: Hess
authors.forename: Emil
authors.initials: E
authors.lastname: Lobkovosky
authors.forename: Cong
authors.initials: C
authors.lastname: Ma
authors.forename: Yuhao
authors.initials: Y
authors.lastname: Ren
authors.forename: Gary A
authors.initials: GA
authors.lastname: Strobel
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry / Q000166:cytology / Q000302:isolation & purification / Q000502:physiology*; D031601:Azadirachta / Q000382:microbiology* / Q000502:physiology; D018360:Crystallography, X-Ray; D008969:Molecular Sequence Data; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D011549:Pseudomonas / Q000187:drug effects; D013559:Symbiosis
chemical_list: D000900:Anti-Bacterial Agents; D009285:Naphthoquinones