A distinctive translocation carcinoma of the kidney ["rosette-like forming," t(6;11), HMB45-positive renal tumor].
OBJECTIVE
Recently, a novel renal carcinoma with specific clinical and histological characteristics and translocation t(6;11)(p21.1;q12 or q13) has been identified. We have found 11 cases in the literature, and we are adding another 3 cases.


METHODS
Three cases were found in the Plzen pathological register with approximately 15,000 cases of kidney tumors. There were two females and 1 male, aged 22, 24, and 39 years.


RESULTS
The sizes of the tumors were 40, 136, and 10 mm. Two tumors were found incidentally; the biggest one was self-palpated by a 24-year-old pregnant patient. Patients are without any signs of disease 42, 20, and 17 months after surgery.


CONCLUSIONS
This tumor is a distinctive and rare translocation carcinoma of the kidney [t(6;11), HMB45 positive]. All cases with known clinical data arose in younger people. The malignant potential is probably low.
Hora
Milan
M
Department of Urology, Charles University Hospital, Plzen, Czech Republic. horam@fnplzen.cz
Hes
Ondrej
O
Urge
Tomás
T
Eret
Viktor
V
Klecka
Jirí
J
Michal
Michal
M
D000328:Adult; D000951:Antigens, Neoplasm / Q000032:analysis; D002292:Carcinoma, Renal Cell / Q000737:chemistry / Q000235:genetics*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000737:chemistry / Q000235:genetics*; D008297:Male; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins / Q000032:analysis; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000235:genetics*; D014178:Translocation, Genetic; D055815:Young Adult
D000951:Antigens, Neoplasm; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins