Risk factors of surgical site infection after hepatectomy for liver cancers.
BACKGROUND
Risk factors of surgical site infection (SSI) after hepatectomy under the guideline of Centers for Disease Control and Prevention (CDC) are not well examined.


METHODS
Hospital records of consecutive patients who underwent hepatectomy without biliary reconstruction for liver cancers were reviewed retrospectively. Prophylactic antibiotics were given to patients just before skin incision and every 3 hours during the operations. Clinicopathological factors were compared between patients who developed SSI and those without it.


RESULTS
There were 405 patients identified, and the incidence of SSI was 23 cases (5.8%). In multivariate analysis, intraoperative bowel injury, blood loss >2000 ml, and age older than 65 years were significant risk factors of SSI after hepatectomy.


CONCLUSIONS
Prophylactic antibiotics were necessary only during the operation for most patients who underwent hepatectomy without biliary reconstruction. However, patients with intraoperative bowel injury, blood loss >2000 ml, and age older than 65 years are at risk to develop SSI and might need additional administration of prophylactic antibiotics after surgery.
Kobayashi
Shin
S
National Cancer Center East Hospital, 6-5-1, Chiba, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan. shkobaya@east.ncc.go.jp
Gotohda
Naoto
N
Nakagohri
Toshio
T
Takahashi
Shinichiro
S
Konishi
Masaru
M
Kinoshita
Taira
T
D000367:Age Factors; D000368:Aged; D019072:Antibiotic Prophylaxis; D016063:Blood Loss, Surgical; D005260:Female; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008113:Liver Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D013530:Surgical Wound Infection / Q000453:epidemiology* / Q000517:prevention & control