[Current value of stem-cell transplantation in autoimmune diseases].
Transplantations of autologous or allogeneic stem cells from bone marrow or peripheral blood are preformed for the treatment of resistant autoimmune diseases. Data have been systematically collected since 1996. We describe the historical development of this procedure for autoimmune diseases, the possible mechanisms of action, the options for stem cell collection, purging and conditioning (high-dose chemotherapy, combination with monoclonal anti-T- or B-cell antibodies, total body irradiation), as well as the reported outcomes in the literature.
Kötter
I
I
Abteilung Innere Medizin II, Medizinische Universitätsklinik Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Deutschland. ina.koetter@med.uni-tuebingen.de
Schmalzing
M
M
Henes
J
J
Vogel
W
W
Kanz
L
L
D001171:Arthritis, Juvenile / Q000276:immunology / Q000401:mortality / Q000601:surgery; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000401:mortality / Q000601:surgery; D001327:Autoimmune Diseases / Q000276:immunology / Q000401:mortality / Q000601:surgery*; D001402:B-Lymphocytes / Q000276:immunology; D016026:Bone Marrow Transplantation; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000401:mortality / Q000601:surgery; D009103:Multiple Sclerosis / Q000276:immunology / Q000401:mortality / Q000601:surgery; D036102:Peripheral Blood Stem Cell Transplantation; D016032:Randomized Controlled Trials as Topic; D012595:Scleroderma, Systemic / Q000276:immunology / Q000401:mortality / Q000601:surgery; D033581:Stem Cell Transplantation; D015996:Survival Rate; D013601:T-Lymphocytes / Q000276:immunology; D019172:Transplantation Conditioning; D014182:Transplantation, Autologous; D014657:Vasculitis / Q000276:immunology / Q000401:mortality / Q000601:surgery