title: Impaired urge-to-cough in elderly patients with aspiration pneumonia.
abstract: BACKGROUND
  The down-regulation of the cough reflex in patients with aspiration pneumonia can involve both cortical facilitatory pathways for cough and medullary reflex pathways. In order to study the possible involvement of the supramedullary system in the down-regulation of cough reflex, we evaluated the urge-to-cough in patients with aspiration pneumonia.
  
  
  METHODS
  Cough reflex sensitivity and the urge-to-cough to inhaled citric acid were evaluated in patients with at least a history of aspiration pneumonia and age-matched healthy elderly people. The cough reflex sensitivities were defined as the lowest concentration of citric acid that elicited two or more coughs (C2) and five or more coughs (C5). The urge-to-cough scores at the concentration of C2 and C5, and at the concentration of two times dilution of C2 (C2/2) and C5 (C5/2) were estimated for each subject.
  
  
  RESULTS
  Both C2 and C5 in the control subjects were significantly greater than those for patients with aspiration pneumonia. There were no significant differences in the urge-to-cough at C2 and C5 between control subjects and patients with aspiration pneumonia. However, the urge-to-cough scores at both C2/2 and C5/2 in patients with aspiration pneumonia were significantly lower than those in control subjects. The number of coughs at C5/2 was significantly greater in the control subjects than those in the patients with aspiration pneumonia whereas the number of coughs at C2/2 did not show a significant difference between the control subjects and the patients with aspiration pneumonia.
  
  
  CONCLUSIONS
  The study suggests the involvement of supramedullary dysfunction in the etiology of aspiration pneumonia in the elderly. Therefore, restoration of the cough motivation system could be a new strategy to prevent aspiration pneumonia in the elderly.
authors.affiliation: Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Seiryo-machi 4-1, Aoba-ku, Sendai 980-8575, Japan. .
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Yamanda
authors.forename: Satoru
authors.initials: S
authors.lastname: Ebihara
authors.forename: Takae
authors.initials: T
authors.lastname: Ebihara
authors.forename: Miyako
authors.initials: M
authors.lastname: Yamasaki
authors.forename: Takaaki
authors.initials: T
authors.lastname: Asamura
authors.forename: Masanori
authors.initials: M
authors.lastname: Asada
authors.forename: Kaori
authors.initials: K
authors.lastname: Une
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Arai