Short communication: Long-term persistence of vaccine-induced HIV seropositivity among healthy volunteers.
Long-term persistence of HIV vaccine-induced seropositivity in uninfected HIV vaccine recipients remains unknown. The duration of HIV humoral-induced responses was assessed in 72 volunteers who had received rgp160 and/or HIV recombinant canarypox virus constructs able to induce immune responses detectable using standard serological tests. Among the 43 rgp160 recipients, 94% and 83% remained HIV seropositive after 5 and 8 years of follow-up, respectively, while all the 29 volunteers who had received canarypox constructs alone were seronegative after 5 years. Because rgp160 induces long-term persistence (>8 years) of vaccine-induced HIV seropositivity, volunteers should be offered long-term follow-up to monitor their serological evolution.
Silbermann
Benjamin
B
AP-HP, Groupe Hospitalier Cochin-Saint-Vincent de Paul, CIC de Vaccinologie Cochin-Pasteur, Pôle de Médecine, Paris, France.
Tod
Michel
M
Desaint
Corinne
C
Pialoux
Gilles
G
Petitprez
Karine
K
Slama
Laurence
L
Poncelet
Hubert
H
Moreau
Corinne
C
Mazarin
Veronique
V
Heshmati
Farad
F
Salmon-Ceron
Dominique
D
Guillet
Jean-Gerard
JG
Launay
Odile
O
D016915:AIDS Vaccines / Q000276:immunology*; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D015483:HIV Antibodies / Q000097:blood*; D006679:HIV Seropositivity / Q000276:immunology; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014614:Vaccines, Synthetic / Q000276:immunology
D016915:AIDS Vaccines; D015483:HIV Antibodies; D014614:Vaccines, Synthetic