title: Prevalence, awareness, treatment and control of hypertension in healthy unrelated male-female pairs of European regions: the dietary habit profile in European communities with different risk of myocardial infarction--the impact of migration as a model of gene-environment interaction project.
abstract: BACKGROUND
  Blood pressure control is of great importance in the prevention of cardiovascular events.
  
  
  OBJECTIVE
  To determine the prevalence, awareness, treatment and control of hypertension in healthy unrelated male-female pairs of European regions.
  
  
  METHODS
  The dietary habit profile in European communities with different risk of myocardial infarction: the impact of migration as a model of gene-environment interaction (IMMIDIET) project was a cross-sectional study to investigate differences in the distribution of cardiovascular risk factors and dietary habits in healthy unrelated male-female pairs married or living together in European regions. Eight hundred and two unrelated male-female pairs were randomly recruited in Abruzzo (Italy), Limburg (Belgium) and south-west London (England). Blood pressure was measured using an automated device. Hypertension was defined as systolic blood pressure of at least 140 mmHg or diastolic blood pressure of at least 90 mmHg or current antihypertensive treatment.
  
  
  RESULTS
  Overall, 24.4% of the population was hypertensive; among them, one-third was on antihypertensive treatment, but a significant proportion (56%) was unaware of the high blood pressure levels. Men were more often hypertensive than women (29.4 vs. 19.5%, P < 0.0001). Women were more often treated than men (49.8 vs. 28.9%, P < 0.0001). Women from south-west London showed blood pressure levels lower than those from Abruzzo and Limburg (P < 0.001 for both, adjusted for age, BMI and social status). No difference among countries was found in blood pressure levels in men. The adjusted prevalence of hypertension was 20.8% in south-west London, 23.6% in Limburg and 28.87% in Abruzzo (Abruzzo vs. south-west London P = 0.005). The prevalence of antihypertensive treatment was 43.5, 42.5 and 32.1% in Abruzzo, Limburg and south-west London, respectively. Out of those treated for hypertension, 42, 43 and 47.7% in Abruzzo, Limburg and south-west London, respectively, were well controlled.
  
  
  CONCLUSIONS
  In communities of healthy unrelated male-female pairs from three different European regions, more than half of hypertensive patients appeared to have blood pressure levels not at target values. Interventions are required to optimize the use and effectiveness of antihypertensive drug therapy in these patients.
authors.affiliation: Laboratory of Genetic and Environmental Epidemiology, Research Laboratories, John Paul II Center for High Technology Research, Care and Education in Biomedical Sciences, Catholic University, Campobasso, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Costanzo
authors.forename: Augusto
authors.initials: A
authors.lastname: Di Castelnuovo
authors.forename: Francesco
authors.initials: F
authors.lastname: Zito
authors.forename: Vittorio
authors.initials: V
authors.lastname: Krogh
authors.forename: Alfonso
authors.initials: A
authors.lastname: Siani
authors.forename: Jozef
authors.initials: J
authors.lastname: Arnout
authors.forename: Francesco P
authors.initials: FP
authors.lastname: Cappuccio
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Miller
authors.forename: Martien
authors.initials: M
authors.lastname: van Dongen
authors.forename: Michel
authors.initials: M
authors.lastname: de Lorgeril
authors.forename: Giovanni
authors.initials: G
authors.lastname: de Gaetano
authors.forename: Maria Benedetta
authors.initials: MB
authors.lastname: Donati
authors.forename: Licia
authors.initials: L
authors.lastname: Iacoviello
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001364:Awareness; D001530:Belgium / Q000453:epidemiology; D004641:Emigration and Immigration; D004739:England / Q000453:epidemiology; D005191:Family Characteristics; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000453:epidemiology* / Q000235:genetics; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D008957:Models, Genetic; D009203:Myocardial Infarction / Q000453:epidemiology*; D015995:Prevalence; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: D000959:Antihypertensive Agents