Hematological abnormalities in adult patients with Down's syndrome.
BACKGROUND
There is a paucity of data regarding hematological abnormalities in adults with Down's syndrome (DS).


OBJECTIVE
We aimed to characterize hematological abnormalities in adult patients with DS and determine their long-term significance.


METHODS
We retrospectively studied a cohort of nine DS patients referred to the adult hematology service in our institution between May 2001 and April 2008. Data collected were: full blood count (FBC), comorbidities, investigations performed, duration of follow-up and outcome to most recent follow-up.


RESULTS
Median follow-up was 26 months (9-71). Of the nine patients, two had myelodysplastic syndrome (MDS) at presentation. Of these, one progressed, with increasing marrow failure, and requiring support with transfusions and gCSF. The remaining eight patients, with a variety of hematological abnormalities including leukopenia, macrocytosis, and thrombocytopenia, had persistently abnormal FBCs. However there was no evidence of progression, and no patient has evolved to acute myeloid leukemia (AML).


CONCLUSIONS
MDS is a complication of DS and may require supportive therapy. However, minor hematological abnormalities are common in adult DS patients, and may not signify underlying marrow disease.
McLean
S
S
Department of Haematology, Adelaide and Meath Hospital, Dublin, Incorporating the National Children's Hospital, Tallaght, D24, Dublin, Ireland. Smclean81@yahoo.com
McHale
C
C
Enright
H
H
D000328:Adult; D004314:Down Syndrome / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007494:Ireland / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology*; D012189:Retrospective Studies