Congenital bilateral perisylvian syndrome: familial occurrence, clinical and psycholinguistic aspects correlated with MRI.
OBJECTIVE
Congenital bilateral perisylvian syndrome (CBPS) is frequently caused by polymicrogyria (PMG). The aim of this study was to correlate the clinical and psycholinguistic aspects with neuroradiological data of patients with CBPS.


METHODS
Thirty-one patients were studied. We performed a clinical investigation of the patients and their families, including MRI scanning, neuropsychological tests and language evaluation.


RESULTS
The statistical analysis showed that: a) prenatal events are associated with the non-familial type of PMG; b) diffuse PMG is associated with pseudobulbar signs, as opposed to BPPP; c) motor deficit is associated with diffuse PMG; d) epilepsy is equally present in patients with both familial or non-familial PMG, but is more frequently seen in patients with diffuse PMG; e) dyslexia and SLI can be a feature of both the diffuse or BPPP, and either familial or sporadic cases of PMG.


CONCLUSIONS
The severity of clinical manifestations in CBPS is correlated with the extent of cortical involvement. Most patients with CBPS have a history of speech delay or language difficulties and no epilepsy. Dyslexia can be found in patients with PMG.
Brandão-Almeida
I L
IL
Department of Medical Genetics, State University of Campinas (Unicamp), Campinas, SP, Brazil.
Hage
S R V
SR
Oliveira
E P M
EP
Guimarães
C A
CA
Teixeira
K C S
KC
Abramides
D V M
DV
Montenegro
M A
MA
Santos
N F
NF
Cendes
F
F
Lopes-Cendes
I
I
Guerreiro
M M
MM
D000293:Adolescent; D000328:Adult; D000368:Aged; D002540:Cerebral Cortex / Q000002:abnormalities* / Q000473:pathology / Q000503:physiopathology; D002648:Child; D004410:Dyslexia / Q000209:etiology / Q000473:pathology; D004827:Epilepsy / Q000151:congenital / Q000209:etiology / Q000473:pathology; D005192:Family Health; D005260:Female; D006801:Humans; D007805:Language Development Disorders / Q000209:etiology / Q000503:physiopathology; D007807:Language Tests / Q000706:statistics & numerical data; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D054220:Malformations of Cortical Development / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D008875:Middle Aged; D009421:Nervous System Malformations / Q000145:classification / Q000175:diagnosis* / Q000235:genetics; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D010375:Pedigree; D011446:Prospective Studies; D011578:Psycholinguistics / Q000379:methods*; D012307:Risk Factors; D013577:Syndrome; D055815:Young Adult