title: Synthesis of BODIPY-labeled alkylphosphocholines with leishmanicidal activity, as fluorescent analogues of miltefosine.
abstract: Two general synthetic methods are described, by which the highly fluorescent and photostable BODIPY group can be inserted in and aligned with the alkyl backbone of linear lipids. These methods have been used to prepare strongly emitting analogues of the leishmanicidal drug miltefosine, in which the antiparasite activity in vitro of the original drug is preserved.
authors.affiliation: Instituto de Química Orgánica, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain.
authors.forename: Valentín
authors.initials: V
authors.lastname: Hornillos
authors.forename: Eugenia
authors.initials: E
authors.lastname: Carrillo
authors.forename: Luis
authors.initials: L
authors.lastname: Rivas
authors.forename: Francisco
authors.initials: F
authors.lastname: Amat-Guerri
authors.forename: A Ulises
authors.initials: AU
authors.lastname: Acuña
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001896:Boron Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D007893:Leishmania donovani / Q000378:metabolism*; D008055:Lipids / Q000737:chemistry; D008956:Models, Chemical; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology; D012997:Solvents / Q000737:chemistry; D013053:Spectrophotometry / Q000379:methods
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D000981:Antiprotozoal Agents; D001896:Boron Compounds; D005456:Fluorescent Dyes; D008055:Lipids; D012997:Solvents; D010767:Phosphorylcholine; C039128:miltefosine