title: Perception measurement in clinical trials of schizophrenia: promising paradigms from CNTRICS.
abstract: The third meeting of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) focused on selecting promising measures for each of the cognitive constructs selected in the first CNTRICS meeting. In the domain of perception, the 2 constructs of interest were gain control and visual integration. CNTRICS received 5 task nominations for gain control and three task nominations for visual integration. The breakout group for perception evaluated the degree to which each of these tasks met prespecified criteria. For gain control, the breakout group for perception believed that 2 of the tasks (prepulse inhibition of startle and mismatch negativity) were already mature and in the process of being incorporated into multisite clinical trials. However, the breakout group recommended that steady-state visual-evoked potentials be combined with contrast sensitivity to magnocellular vs parvocellular biased stimuli and that this combined task and the contrast-contrast effect task be recommended for translation for use in clinical trial contexts in schizophrenia research. For visual integration, the breakout group recommended the Contour Integration and Coherent Motion tasks for translation for use in clinical trials. This manuscript describes the ways in which each of these tasks met the criteria used by the breakout group to evaluate and recommend tasks for further development.
authors.affiliation: Semel Institute, UCLA, CA, USA. mgreen@ucla.edu
authors.forename: Michael F
authors.initials: MF
authors.lastname: Green
authors.forename: Pamela D
authors.initials: PD
authors.lastname: Butler
authors.forename: Yue
authors.initials: Y
authors.lastname: Chen
authors.forename: Mark A
authors.initials: MA
authors.lastname: Geyer
authors.forename: Steven
authors.initials: S
authors.lastname: Silverstein
authors.forename: Jonathan K
authors.initials: JK
authors.lastname: Wynn
authors.forename: Jong H
authors.initials: JH
authors.lastname: Yoon
authors.forename: Vance
authors.initials: V
authors.lastname: Zemon
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D005074:Evoked Potentials, Visual / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D010468:Perceptual Disorders / Q000175:diagnosis / Q000209:etiology*; D011594:Psychometrics; D013216:Reflex, Startle; D012559:Schizophrenia / Q000150:complications* / Q000503:physiopathology; D014796:Visual Perception