Regulation of the Na+-Cl- cotransporter by dietary NaCl: a role for WNKs, SPAK, OSR1, and aldosterone.
This Commentary aims to integrate or interrelate the available data with the current study by Chiga and co-workers, which defines an important influence of aldosterone in the phosphorylation and thus activation of the Na(+)-Cl(-) cotransporter (NCC) in response to changes in NaCl intake and implicates the involvement of SPAK/OSR1 kinases and WNKs.
Vallon
Volker
V
Department of Medicine, University of California, San Diego, California, USA. vvallon@ucsd.edu
D000450:Aldosterone / Q000502:physiology*; D000818:Animals; D004032:Diet; D051379:Mice; D015778:Minor Histocompatibility Antigens; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D012965:Sodium Chloride / Q000494:pharmacology*; D049992:Sodium Chloride Symporters / Q000187:drug effects* / Q000378:metabolism; D000076204:WNK Lysine-Deficient Protein Kinase 1
D015778:Minor Histocompatibility Antigens; D049992:Sodium Chloride Symporters; D012965:Sodium Chloride; D000450:Aldosterone; C499024:Prkwnk4 protein, mouse; C486407:Stk39 protein, mouse; C534421:OXSR1 protein, mouse; D017346:Protein Serine-Threonine Kinases; D000076204:WNK Lysine-Deficient Protein Kinase 1; C498744:Wnk1 protein, mouse