title: Intraoperative contrast-enhanced ultrasound for brain tumors.
abstract: OBJECTIVE
  The purpose of this study was to investigate the feasibility and value of the intraoperative contrast-enhanced ultrasound (CEUS) in resection for brain tumors.
  
  
  METHODS
  Intraoperative CEUS was performed in 29 patients with brain tumors pre-resection, in whom 9 (of 29) patients underwent second intraoperative CEUS for assessing remained tumor tissue after initial resection. Gray-scale and color-flow images of the brain tumors on both conventional and CEUS were analyzed and compared with the results of surgical pathology.
  
  
  RESULTS
  The border of the tumor and remained tumor tissue was more distinguishable from healthy brain on CEUS than that on conventional ultrasound during the operation. Improving definition of the tumor tissue from normal brain with CEUS was demonstrated in all cases.
  
  
  CONCLUSIONS
  Intraoperative CEUS has the potential to be a very useful imaging technique not only in defining the border between the tumor and healthy brain pre resection but also in detecting remained tumor tissues after the initial resection.
authors.affiliation: Department of Ultrasound, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. hewen168@sohu.com
authors.forename: Wen
authors.initials: W
authors.lastname: He
authors.forename: Xiao-qian
authors.initials: XQ
authors.lastname: Jiang
authors.forename: Shuo
authors.initials: S
authors.lastname: Wang
authors.forename: Mao-zhi
authors.initials: MZ
authors.lastname: Zhang
authors.forename: Ji-zong
authors.initials: JZ
authors.lastname: Zhao
authors.forename: Hui-zhao
authors.initials: HZ
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
authors.forename: Dong-ying
authors.initials: DY
authors.lastname: Xiang
authors.forename: Li-shu
authors.initials: LS
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000465:Algorithms; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery*; D002648:Child; D003287:Contrast Media; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008297:Male; D016343:Monitoring, Intraoperative / Q000379:methods; D010743:Phospholipids; D011379:Prognosis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013459:Sulfur Hexafluoride; D025321:Surgery, Computer-Assisted / Q000379:methods*; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional / Q000379:methods*; D055815:Young Adult
chemical_list: D003287:Contrast Media; D010743:Phospholipids; C420843:contrast agent BR1; D013459:Sulfur Hexafluoride