Activated protein C resistance, factor V Leiden and assessment of thrombotic risk.
Venous thromboembolism comprises deep vein thrombosis (DVT) and pulmonary embolism (PE). Acute venous thromboembolism (VTE) is a serious and potentially fatal disorder which often complicates the course of hospitalized patients, but also affects ambulatory and otherwise healthy people. The annual incidence of venous thromboembolism is 1 to 2 cases per 1000 person and the risk of the disorder rises exponentially with age, from an annual rate of less than 5 per 100,000 children to greater than 400 per 100,000 adults older than 80 years.
Gilmore
R
R
National Centre for Hereditary Coagulation Disorders, St James's Hospital, James's Street, Dublin. rgilmore@stjames.ie
Doyle
M
M
Holden
F
F
White
B
B
O'Donnell
J
J
D020016:Activated Protein C Resistance / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D005165:Factor V; D006801:Humans; D008297:Male; D011655:Pulmonary Embolism / Q000209:etiology*; D018570:Risk Assessment; D012307:Risk Factors; D054556:Venous Thromboembolism / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D020246:Venous Thrombosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D055815:Young Adult
D000925:Anticoagulants; C095381:factor V Leiden; D005165:Factor V