title: Demethoxycurcumin and its semisynthetic analogues as antitubercular agents.
abstract: Demethoxycurcumin, isolated from the rhizomes of Curcuma longa, was found to possess antitubercular activity against Mycobacterium tuberculosis H (37)Rv strain at 200 microg/mL. Derivatisation of this active principle yielded a potent agent 6, exhibiting considerable activity with a minimum inhibitory concentration (MIC) value of 7.8 microg/mL. H (37)Rv:Mycobacterium tuberculosis H (37)Rv strain MIC:minimum inhibitory concentration.
authors.affiliation: Analytical Chemistry Division, Central Institute of Medicinal and Aromatic Plants (CIMAP-CSIR), Lucknow, India.
authors.forename: Dinesh Kumar
authors.initials: DK
authors.lastname: Agrawal
authors.forename: Dharmendra
authors.initials: D
authors.lastname: Saikia
authors.forename: Richa
authors.initials: R
authors.lastname: Tiwari
authors.forename: Shweta
authors.initials: S
authors.lastname: Ojha
authors.forename: Karuna
authors.initials: K
authors.lastname: Shanker
authors.forename: Jonnala Kotesh
authors.initials: JK
authors.lastname: Kumar
authors.forename: Anil Kumar
authors.initials: AK
authors.lastname: Gupta
authors.forename: Sudeep
authors.initials: S
authors.lastname: Tandon
authors.forename: Arvind Singh
authors.initials: AS
authors.lastname: Negi
authors.forename: Suman Preet
authors.initials: SP
authors.lastname: Khanuja
mesh_terms: D000995:Antitubercular Agents / Q000302:isolation & purification / Q000494:pharmacology*; D030024:Curcuma / Q000737:chemistry*; D003474:Curcumin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D036381:Diarylheptanoids; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D027343:Rhizome
chemical_list: D000995:Antitubercular Agents; D036381:Diarylheptanoids; D010936:Plant Extracts; D003474:Curcumin; C050229:demethoxycurcumin