title: A case of uterine cervical adenocarcinoma associated with small cell carcinoma.
abstract: Extrapulmonary small cell carcinomas are often associated with carcinomas of other cell types. Although a hypothesis that extrapulmonary small cell carcinomas arise from a multipotential stem cell could explain this mixed feature, recent molecular evidence supports another possibility that the small cell component may arise as a late-stage phenomenon in the progression of more organ-typical carcinomas. Here, we report a case of uterine cervical adenocarcinoma containing 30% of small cell carcinoma. Adenocarcinoma was located in the endometrial side of the tumor that was adjacent to the normal cervical region, while small cell carcinoma was located in the periphery of the tumor. The transition from adenocarcinoma to small cell carcinoma was observed in the boundary area. These findings suggest that cervical small cell carcinoma can be differentiated from pre-existing adenocarcinoma and offer further support to the hypothesis that the small cell component arises as a late-stage phenomenon in the progression of more organ-typical carcinomas.
authors.affiliation: Department of Obstetrics, National Hospital Organization, Osaka National Hospital, Osaka, Japan.
authors.forename: Mahiru
authors.initials: M
authors.lastname: Kamiya
authors.forename: Yukiyasu
authors.initials: Y
authors.lastname: Sato
authors.forename: Hisanori
authors.initials: H
authors.lastname: Matsumoto
authors.forename: Hiroe
authors.initials: H
authors.lastname: Sasaki
authors.forename: Shugen
authors.initials: S
authors.lastname: Takahashi
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Yamada
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ito
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Okagaki
authors.forename: Youko
authors.initials: Y
authors.lastname: Iwasa
authors.forename: Chiaki
authors.initials: C
authors.lastname: Ban
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery; D018288:Carcinoma, Small Cell / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery