title: Chapter 11. The role of bone marrow-derived cells in tumor angiogenesis and metastatic progression.
abstract: Tumor angiogenesis is orchestrated by a complex set of secreted factors and collaboration between many different cell types. This chapter discusses the role of tumor-secreted angiogenic factors that are responsible for the recruitment of bone marrow-derived cells (BMDCs) at tumor sites and their role in tumor angiogenesis and progression.
authors.affiliation: Department of Pediatrics and Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, USA.
authors.forename: Marianna
authors.initials: M
authors.lastname: Papaspyridonos
authors.forename: David
authors.initials: D
authors.lastname: Lyden
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology*; D002454:Cell Differentiation; D002465:Cell Movement; D054377:Chemokine CXCL12 / Q000378:metabolism; D018450:Disease Progression; D006801:Humans; D009362:Neoplasm Metastasis / Q000473:pathology; D009369:Neoplasms / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology*; D009389:Neovascularization, Pathologic; D019718:Receptors, CXCR4 / Q000378:metabolism; D040262:Receptors, Vascular Endothelial Growth Factor / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D054377:Chemokine CXCL12; D019718:Receptors, CXCR4; D040262:Receptors, Vascular Endothelial Growth Factor