Loss of the mitochondrial nucleoid protein, Abf2p, destabilizes repetitive DNA in the yeast mitochondrial genome.
Loss of Abf2p, an abundant mitochondrial nucleoid-associated protein, results in increased mitochondrial frameshifts and direct-repeat mediated deletions but has no effect on the rate of mitochondrial point mutations. The instability of repeated sequences in this strain may be linked to the loss of mitochondrial DNA in abf2-Delta strains.
Sia
Rey A
RA
Department of Biological Sciences, The College at Brockport, State University of New York, Brockport, NY 14420, USA. rsia@brockport.edu
Carrol
Stephanie
S
Kalifa
Lidza
L
Hochmuth
Christine
C
Sia
Elaine A
EA
D000332:Aerobiosis / Q000528:radiation effects; D004272:DNA, Mitochondrial / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000172:deficiency* / Q000378:metabolism; D017930:Genes, Reporter; D054629:Genome, Mitochondrial / Q000235:genetics*; D042822:Genomic Instability / Q000528:radiation effects; D050296:Microbial Viability / Q000528:radiation effects; D009154:Mutation / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000235:genetics* / Q000528:radiation effects; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D014157:Transcription Factors / Q000172:deficiency* / Q000378:metabolism; D014466:Ultraviolet Rays
C072843:ABF2 protein, S cerevisiae; D004272:DNA, Mitochondrial; D004268:DNA-Binding Proteins; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors