Dietary activators of Sirt1.
Calorie restriction (CR) is a non-genetic manipulation that reliably results in extended lifespan of several species ranging from yeast to dogs. The lifespan extension effect of CR has been strongly associated with an increased level and activation of the silent information regulator 2 (Sir2) histone deacetylase and its mammalian ortholog Sirt1. This association led to the search for potential Sirt1-activating, life-extending molecules. This review briefly outlines the experimental findings on resveratrol and other dietary activators of Sirt1.
Allard
Joanne S
JS
Laboratory of Experimental Gerontology, National Institute on Aging, 6200 Seaforth Street, National Institutes of Health, Baltimore, MD 21224, USA.
Perez
Evelyn
E
Zou
Sige
S
de Cabo
Rafael
R
D000818:Animals; D017173:Caenorhabditis elegans / Q000378:metabolism / Q000502:physiology; D031204:Caloric Restriction; D004032:Diet; D019587:Dietary Supplements; D004331:Drosophila melanogaster / Q000378:metabolism / Q000502:physiology; D004789:Enzyme Activation / Q000187:drug effects; D005419:Flavonoids / Q000494:pharmacology; D006655:Histone Deacetylases / Q000378:metabolism; D006801:Humans; D010636:Phenols / Q000494:pharmacology; D059808:Polyphenols; D012441:Saccharomyces cerevisiae / Q000378:metabolism / Q000502:physiology; D037761:Sirtuins / Q000378:metabolism*; D014714:Vertebrates / Q000378:metabolism / Q000502:physiology
D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D037761:Sirtuins; D006655:Histone Deacetylases