Adipocyte metabolism and obesity.
Adipose tissue metabolism exerts a profound impact on whole-body metabolism. We review how fuel partitioning between adipocytes and other tissues affects insulin signaling pathways. We discuss the role of adipose tissue inflammation in adipocyte metabolism and whole-body insulin sensitivity. Finally, we mention the role of adipokines in autocrine and paracrine signaling.
Attie
Alan D
AD
Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA. adattie@wisc.edu
Scherer
Philipp E
PE
D017667:Adipocytes / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000276:immunology / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism; D009765:Obesity / Q000378:metabolism*; D017510:Protein Folding; D013312:Stress, Physiological