Nuclear motors and nuclear structures containing A-type lamins and emerin: is there a functional link?
Rapid interphase chromosome territory repositioning appears to function through the action of nuclear myosin and actin, in a nuclear motor complex. We have found that chromosome repositioning when cells leave the cell cycle is not apparent in cells that have mutant lamin A or that are lacking emerin. We discuss the possibility that there is a functional intranuclear complex comprising four proteins: nuclear actin, lamin A, emerin and nuclear myosin. If any of the components are lacking or aberrant, then the nuclear motor complex involved in moving chromosomes or genes will be dysfunctional, leading to an inability to move chromosomes in response to signalling events.
Mehta
Ishita S
IS
Division of Biosciences, Laboratory of Nuclear and Genomic Health, Centre for Cell and Chromosome Biology, School of Health Sciences and Social Care, Brunel University, Uxbridge, UK.
Elcock
Lauren S
LS
Amira
Manelle
M
Kill
Ian R
IR
Bridger
Joanna M
JM
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D045584:Chromosome Positioning; D006801:Humans; D034904:Lamin Type A / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D020409:Molecular Motor Proteins / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism*
D034904:Lamin Type A; D008565:Membrane Proteins; D020409:Molecular Motor Proteins; D009687:Nuclear Proteins; C092710:emerin