title: Identity tests: determination of cell line cross-contamination.
abstract: Cell line cross-contamination is a phenomenon that arises as a result of the continuous cell line culture. It has been estimated that around 20% of the cell lines are misidentified, therefore it is necessary to carry out quality control tests for the detection of this issue. Since cell line cross-contamination discovery, different methods have been applied, such as isoenzyme analysis for inter-species cross-contamination; HLA typing, and DNA fingerprinting using short tandem repeat and a variable number of tandem repeat for intra-species cross-contamination. The cell banks in this sense represent the organizations responsible for guaranteeing the authenticity of cell lines for future research and clinical uses.
authors.affiliation: Stem Cell Bank of Andalucia (Spanish Central Node), Hospital Universitario Virgen de las Nieves, Avenida de las Fuerzas Armadas No. 2, 18014, Granada, Spain, mcabrm@fundacionhvn.org.
authors.forename: C M
authors.initials: CM
authors.lastname: Cabrera
authors.forename: F
authors.initials: F
authors.lastname: Cobo
authors.forename: A
authors.initials: A
authors.lastname: Nieto
authors.forename: J L
authors.initials: JL
authors.lastname: Cortés
authors.forename: R M
authors.initials: RM
authors.lastname: Montes
authors.forename: P
authors.initials: P
authors.lastname: Catalina
authors.forename: A
authors.initials: A
authors.lastname: Concha