title: Endometrial intraepithelial carcinoma: a case report and brief review.
abstract: This case report describes the precursor lesion of uterine papillary serous carcinoma (UPSC). A 65-year-old post-menopausal female presented with prolapse and vaginal discharge and underwent a hysterectomy revealing an atrophic endometrium, highly atypical endometrial glands, the lining cells of which showed pseudostratification, hobnailing, a high nuclear to cytoplasmic ratio, and prominent nucleoli. A p53 immunoreactivity score of 8 and a MIB-1 index of 80% was obtained leading to a diagnosis of endometrial intraepithelial carcinoma (EIC). Since serous EIC is commonly associated with extra-uterine serous carcinoma, it is a uniquely aggressive precursor lesion. Molecular studies support the hypothesis that EIC is a precursor of both uterine and extra-uterine invasive serous carcinomas. This is why the treatment protocol for EIC cases is total abdominal hysterectomy (TAH), accompanied by a staging procedure. In our patient, EIC was limited to the endometrium; associated with an excellent clinical outcome.
authors.affiliation: Department of Cellular Pathology, The Princess Alexandra Hospital, Harlow, Essex CM20 1QX, United Kingdom. pathologist.manisha@gmail.com
authors.forename: Manisha
authors.initials: M
authors.lastname: Ram
authors.forename: Minakshi
authors.initials: M
authors.lastname: Bharadwaj
authors.forename: Rajbala
authors.initials: R
authors.lastname: Yadav
mesh_terms: D000368:Aged; D002278:Carcinoma in Situ / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology*; D002291:Carcinoma, Papillary / Q000378:metabolism / Q000473:pathology; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology*; D004717:Endometrium / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D011230:Precancerous Conditions / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D014594:Uterine Neoplasms / Q000378:metabolism / Q000473:pathology
chemical_list: D016159:Tumor Suppressor Protein p53