Urinary excretion of ganciclovir contributes to improvement of adenovirus-associated hemorrhagic cystitis after allogeneic bone marrow transplantation.
A nine-yr-old girl developed AdV-associated HC after bone marrow transplantation. Intravenous GCV markedly reduced urinary AdV DNA loads and improved clinical findings. This appeared to result partly from a high concentration of GCV in urine. GCV may be effective for AdV-induced HC without definitive disseminated infection.
Nakazawa
Yozo
Y
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
Suzuki
Takefumi
T
Fukuyama
Tetsuhiro
T
Katsuyama
Yoshihiko
Y
Tanaka
Miyuki
M
Yanagisawa
Ryu
R
Sakashita
Kazuo
K
Shiohara
Masaaki
M
Koike
Kenichi
K
D000256:Adenoviridae / Q000378:metabolism*; D000257:Adenoviridae Infections / Q000175:diagnosis / Q000652:urine; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D045744:Cell Line, Tumor; D002648:Child; D003556:Cystitis / Q000188:drug therapy* / Q000821:virology; D005260:Female; D015774:Ganciclovir / Q000627:therapeutic use / Q000652:urine*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D012307:Risk Factors; D014184:Transplantation, Homologous
D007166:Immunosuppressive Agents; D015774:Ganciclovir