Bcl-3, a multifaceted modulator of NF-kappaB-mediated gene transcription.
The transcription factor, NF-kappaB (nuclear factor-kappaB) and associated regulatory factors make up a multi-component signaling pathway that regulates a wide range of biological processes, including cell survival, proliferation, differentiation, stress response, and death, as well as immunity and inflammation. Aberrant NF-kappaB pathway activity is known to be associated with a host of diseases, including immune deficiencies, inflammatory disorders, and cancer. Recent advances in our understanding of the inner workings of the NF-kappaB pathway have led to the development of new therapeutic strategies for the treatment of these diseases. In this review, we focus on the regulation of the NF-kappaB pathway by Bcl-3 (B cell leukemia-3), a nuclear member of the IkappaB (inhibitor of NF-kappaB) family. Both the regulation and the function of Bcl-3 will be discussed.
Palmer
Scott
S
Department of Pathology and Laboratory of Medicine, School of Medicine, University of Pennsylvania, 713 Stellar Chance Labs. 422 Curie Blvd., Philadelphia, PA, 19104, USA. scpalmer@mail.med.upenn.edu
Chen
Youhai H
YH
D000818:Animals; D000081242:B-Cell Lymphoma 3 Protein; D005786:Gene Expression Regulation; D006801:Humans; D016328:NF-kappa B / Q000502:physiology*; D011499:Protein Processing, Post-Translational; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D020871:RNA Stability; D014157:Transcription Factors / Q000502:physiology*; D014158:Transcription, Genetic / Q000235:genetics
D000081242:B-Cell Lymphoma 3 Protein; C000631344:BCL3 protein, human; D016328:NF-kappa B; D011518:Proto-Oncogene Proteins; D014157:Transcription Factors