title: A role for the body burden of aluminium in vaccine-associated macrophagic myofasciitis and chronic fatigue syndrome.
abstract: Macrophagic myofasciitis and chronic fatigue syndrome are severely disabling conditions which may be caused by adverse reactions to aluminium-containing adjuvants in vaccines. While a little is known of disease aetiology both conditions are characterised by an aberrant immune response, have a number of prominent symptoms in common and are coincident in many individuals. Herein, we have described a case of vaccine-associated chronic fatigue syndrome and macrophagic myofasciitis in an individual demonstrating aluminium overload. This is the first report linking the latter with either of these two conditions and the possibility is considered that the coincident aluminium overload contributed significantly to the severity of these conditions in this individual. This case has highlighted potential dangers associated with aluminium-containing adjuvants and we have elucidated a possible mechanism whereby vaccination involving aluminium-containing adjuvants could trigger the cascade of immunological events which are associated with autoimmune conditions including chronic fatigue syndrome and macrophagic myofasciitis.
authors.affiliation: Birchall Centre for Inorganic Chemistry and Materials Science, Keele University, Staffordshire ST5 5BG, UK. c.exley@chem.keele.ac.uk
authors.forename: Christopher
authors.initials: C
authors.lastname: Exley
authors.forename: Louise
authors.initials: L
authors.lastname: Swarbrick
authors.forename: Rhomain K
authors.initials: RK
authors.lastname: Gherardi
authors.forename: Francois-Jérôme
authors.initials: FJ
authors.lastname: Authier
mesh_terms: D000276:Adjuvants, Immunologic / Q000009:adverse effects*; D000328:Adult; D000535:Aluminum / Q000633:toxicity* / Q000652:urine; D001822:Body Burden; D015673:Fatigue Syndrome, Chronic / Q000139:chemically induced* / Q000473:pathology; D005356:Fibromyalgia / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000473:pathology
chemical_list: D000276:Adjuvants, Immunologic; D000535:Aluminum