Correlation between changes in CSF dopamine turnover and development of dyskinesia in Parkinson's disease.
To assess possible differences in dopamine metabolism that could parallel disease progression in Parkinson's disease (PD), we measured dopamine (DA) and its metabolites in the cerebrospinal fluid (CSF) in PD patients at different stages of disease: de novo (DEN), advanced not showing dyskinesias (ADV), and advanced with dyskinesias (DYS). DA, homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC) were significantly higher in DEN patients compared with other groups. A negative exponential correlation related DA level and disease duration. The HVA/DA ratio was significantly higher in the ADV and DYS group than that found in DEN group. Our data show that disease progression produces an early large decay of DA levels, followed by a stabilization. On the contrary, a late change in DA turnover (increased HVA/DA ratio) is documented in patients with longer disease duration. Our results suggest that the appearance of dyskinesia may not be related to a further loss of DA terminals but to a different, abnormal, DA turnover.
Lunardi
Gianluigi
G
Section of Pharmacology, Department of Oncology Biology and Genetics, University of Genoa, Italy.
Galati
Salvatore
S
Tropepi
Domenicantonio
D
Moschella
Vincenzo
V
Brusa
Livia
L
Pierantozzi
Mariangela
M
Stefani
Alessandro
A
Rossi
Silvia
S
Fornai
Francesco
F
Fedele
Ernesto
E
Stanzione
Paolo
P
Hainsworth
Atticus H
AH
Pisani
Antonio
A
D015102:3,4-Dihydroxyphenylacetic Acid / Q000134:cerebrospinal fluid; D017668:Age of Onset; D000368:Aged; D018450:Disease Progression; D004298:Dopamine / Q000134:cerebrospinal fluid*; D020820:Dyskinesias / Q000209:etiology* / Q000503:physiopathology; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D008875:Middle Aged; D010300:Parkinson Disease / Q000134:cerebrospinal fluid* / Q000150:complications / Q000503:physiopathology*
D015102:3,4-Dihydroxyphenylacetic Acid; D004298:Dopamine; D006719:Homovanillic Acid