[Breast cancer and endothelial dysfunction].
The main cause of death among Brazilian women is cardiovascular disease followed by cancer with breast cancer as the most incident. The relationship between cancer and thrombosis is well known, although its association with other cardiovascular events is poorly understood. In order to study these events from the earliest findings such as endothelial injury and dysfunction and the evolving atherosclerotic plaque, many methods are currently being used. Among these methods, E- and P-selectin and the von Willebrand factor have been associated, either with cardiovascular risk or with breast cancer growth and metastasis. Brachial artery flow-mediated dilatation is a tool available that emerged in the last decade due to its noninvasive nature and its clear association with endothelial dysfunction and cardiovascular risk. The aim of this revision is to bring the newest and most relevant updates about the association of breast cancer, endothelial injury and cardiovascular risk.
Nastri
Carolina Oliveira
CO
Departamento de Ginecologia e Obstetrícia, Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP. canastri@hotmail.com
Martins
Wellington de Paula
Wde P
Reis
Francisco José Candido dos
FJ
Ferriani
Rui Alberto
RA
D015415:Biomarkers / Q000097:blood; D001916:Brachial Artery / Q000503:physiopathology; D001943:Breast Neoplasms / Q000097:blood / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000097:blood*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D012039:Regional Blood Flow / Q000502:physiology; D012307:Risk Factors; D019087:Selectins / Q000097:blood; D014841:von Willebrand Factor / Q000032:analysis
D015415:Biomarkers; D019087:Selectins; D014841:von Willebrand Factor