title: Competitive repair pathways in immunoglobulin gene hypermutation.
abstract: This review focuses on the contribution of translesion DNA polymerases to immunoglobulin gene hypermutation, in particular on the roles of DNA polymerase eta (Poleta) in the generation of mutations at A/T bases from the initial cytosine-targeted activation-induced cytidine deaminase (AID)-mediated deamination event, and of Polkappa, an enzyme of the same polymerase family, used as a substitute when Poleta is absent. The proposition that the UNG uracil glycosylase and the MSH2-MSH6 mismatch recognition complex are two competitive rather than alternative pathways in the processing of uracils generated by AID is further discussed.
authors.affiliation: INSERM U783 Développement du système immunitaire, Université Paris Descartes, Faculté de Médecine, Site Necker-Enfants Malades, 156 rue de Vaugirard, 75730 Paris Cedex 15, France.
authors.forename: Claude-Agnès
authors.initials: CA
authors.lastname: Reynaud
authors.forename: Frédéric
authors.initials: F
authors.lastname: Delbos
authors.forename: Ahmad
authors.initials: A
authors.lastname: Faili
authors.forename: Quentin
authors.initials: Q
authors.lastname: Guéranger
authors.forename: Said
authors.initials: S
authors.lastname: Aoufouchi
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Weill
mesh_terms: D003564:Cytidine Deaminase / Q000378:metabolism*; D004260:DNA Repair / Q000235:genetics / Q000276:immunology*; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D003641:Deamination; D051719:MutS DNA Mismatch-Binding Protein / Q000235:genetics / Q000378:metabolism; D027041:Somatic Hypermutation, Immunoglobulin / Q000235:genetics*; D051981:Uracil-DNA Glycosidase / Q000378:metabolism; D000099270:Y-Family DNA Polymerases
chemical_list: D003564:Cytidine Deaminase; D004259:DNA-Directed DNA Polymerase; D051719:MutS DNA Mismatch-Binding Protein; D051981:Uracil-DNA Glycosidase; C112338:Rad30 protein; D000099270:Y-Family DNA Polymerases