title: N1-Alkylated 3,4-dihydropyrimidine-2(1H)-ones: Convenient one-pot selective synthesis and evaluation of their calcium channel blocking activity.
abstract: It has been found that selective N1-alkylation of 3,4-dihydropyrimidine-2(1H)-ones can be achieved under solvent-less, mild phase transfer catalytic (PTC) conditions with tetrabutylammonium hydrogen sulfate and 50% aqueous NaOH as the catalyst and base, respectively. The procedure is tolerant to substitutional variation at key diversity points on the pyrimidinone moiety.
authors.affiliation: Organic Synthesis Laboratory, Department of Applied Chemical Sciences and Technology, Guru Nanak Dev University, Amritsar 143 005, India.
authors.forename: Kamaljit
authors.initials: K
authors.lastname: Singh
authors.forename: Divya
authors.initials: D
authors.lastname: Arora
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Poremsky
authors.forename: Jazmyne
authors.initials: J
authors.lastname: Lowery
authors.forename: Robert S
authors.initials: RS
authors.lastname: Moreland
mesh_terms: D000478:Alkylation; D002121:Calcium Channel Blockers / Q000138:chemical synthesis* / Q000494:pharmacology; D002384:Catalysis; D006801:Humans; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D002121:Calcium Channel Blockers; D011744:Pyrimidinones