title: Reversal of opioid-induced gastric dysfunction in a critically ill burn patient after methylnaltrexone.
abstract: Peripheral-acting mu opiate receptor antagonists have been extensively studied for the treatment of opiate-induced constipation in advanced illness for the prophylaxis of postoperative ileus. We document the first intensive care patient to receive methylnaltrexone in an attempt to facilitate enteral nutrition. Gastric residuals markedly decreased and enteral feeding increased after administration of i.v. methylnaltrexone. The patient's ileus resolved coincident with the first injection.
authors.affiliation: Department Anesthesia and Critical Care, The University of Chicago, 5841 S. Maryland Ave., MC 4028, Chicago, IL 60637, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Woo
authors.forename: Michael
authors.initials: M
authors.lastname: O'Connor
authors.forename: Chun-Su
authors.initials: CS
authors.lastname: Yuan
authors.forename: Jonathan
authors.initials: J
authors.lastname: Moss
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000009:adverse effects*; D002056:Burns / Q000601:surgery*; D016638:Critical Illness; D004750:Enteral Nutrition; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D008297:Male; D009271:Naltrexone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009292:Narcotic Antagonists / Q000627:therapeutic use*; D000644:Quaternary Ammonium Compounds / Q000627:therapeutic use
chemical_list: D000701:Analgesics, Opioid; D009292:Narcotic Antagonists; D000644:Quaternary Ammonium Compounds; C032257:methylnaltrexone; D009271:Naltrexone