title: The safety on the TCR trigger.
abstract: In this issue, Xu et al. (2008) provide evidence for a new mechanism of T cell receptor regulation. Prior to activation, basic residues in the cytoplasmic domain of the signaling subunits of the T cell receptor associate with the plasma membrane such that the key signaling tyrosines are sequestered in the bilayer.
authors.affiliation: Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Kuhns
authors.forename: Mark M
authors.initials: MM
authors.lastname: Davis
mesh_terms: D020816:Amino Acid Motifs; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D008051:Lipid Bilayers / Q000378:metabolism; D008954:Models, Biological; D010766:Phosphorylation; D017434:Protein Structure, Tertiary; D011948:Receptors, Antigen, T-Cell / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D008051:Lipid Bilayers; D011948:Receptors, Antigen, T-Cell