title: Investigation between the S377G3 GATA-4 polymorphism and migraine.
abstract: Migraine is a common and painful neurological disorder, with genetic and environmental components. Several conditions have been shown to be comorbid with migraine, notably a cardiac malformation affecting the interatrial septum and leading to patent foramen ovale (PFO). Mutations in the development regulatory gene GATA-4, located on human chromosome 8p23.1-p22, have been found to be responsible for some cases of congenital heart defects including PFO. To determine whether the GATA-4 gene is involved in migraine, the present study performed an association analysis of a common GATA-4 variant that results in a change of amino acid (S377G), in a large case/control population (275 unrelated Caucasian migraineurs versus 275 control individuals). The results showed that there was no significant association for this polymorphism between migraine and controls (chi(2) = 0.84, P = 0.66). Thus it appears that the GATA-4 (S377G) mutation does not play a significant role in common migraine susceptibility.
authors.affiliation: Genomics Research Centre, Griffith University, Gold Coast, Queensland, Australia.
authors.forename: Chikhani
authors.initials: C
authors.lastname: Sherin
authors.forename: Fernandez
authors.initials: F
authors.lastname: Francesca
authors.forename: Poetter
authors.initials: P
authors.lastname: Karl
authors.forename: Toohey
authors.initials: T
authors.lastname: Brendan
authors.forename: Harvey
authors.initials: H
authors.lastname: Ron
authors.forename: Griffiths
authors.initials: G
authors.lastname: Lyn