Synthesis of Gd(III)-C-palmitamidomethyl-C'-DOTAMA-C(6)-o-carborane: a new dual agent for innovative MRI/BNCT applications.
C-(2-Benzyloxy)-ethyl-C'-N-tert-butoxycarbonyl-aminomethyl-o-carborane (8), a potentially useful intermediate for BNCT, has been synthesised. This intermediate can be readily functionalised with several biological vectors and MRI contrast agents. In this work intermediate 8 has been functionalised with a palmityl chain for lipophilic targeting and with Gd(III)-DOTAMA-C(6)-NH(2) as MRI detector. This combination yielded Gd(III)-C-palmitamidomethyl-C'-DOTAMA-C(6)-o-carborane (14) as a dual MRI-BNCT agent.
Aime
Silvio
S
Dipartimento di Chimica IFM, Università degli Studi di Torino, Via Pietro Giuria, 7, 10125, Torino, Italy.
Barge
Alessandro
A
Crivello
Antonella
A
Deagostino
Annamaria
A
Gobetto
Roberto
R
Nervi
Carlo
C
Prandi
Cristina
C
Toppino
Antonio
A
Venturello
Paolo
P
D001896:Boron Compounds / Q000737:chemistry*; D016754:Boron Neutron Capture Therapy; D005682:Gadolinium / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use
D001896:Boron Compounds; D009942:Organometallic Compounds; D005682:Gadolinium