title: Epidemiological investigation and glycotyping of clinical Pseudomonas aeruginosa isolates from patients with cystic fibrosis by mass spectrometry: association with multiple drug resistance.
abstract: The aim of the present investigation was to develop a novel approach for rapid identification and differentiation of Pseudomonas aeruginosa clones from Canadian cystic fibrosis patients by capillary electrophoresis-mass spectrometry. We screened P. aeruginosa isolates for lipopolysaccharide structure and presence/absence of alginate and correlated these findings with antibiotic resistance patterns.
authors.affiliation: Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada. Eleonora.altman@nrc-cnrc.gc.ca
authors.forename: Eleonora
authors.initials: E
authors.lastname: Altman
authors.forename: Zhan
authors.initials: Z
authors.lastname: Wang
authors.forename: Shawn D
authors.initials: SD
authors.lastname: Aaron
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.forename: Katherine L
authors.initials: KL
authors.lastname: Vandemheen
authors.forename: Wendy
authors.initials: W
authors.lastname: Ferris
authors.forename: Tracy
authors.initials: T
authors.lastname: Giesbrecht
authors.forename: Jianjun
authors.initials: J
authors.lastname: Li
mesh_terms: D000464:Alginates; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003550:Cystic Fibrosis / Q000150:complications / Q000382:microbiology*; D024881:Drug Resistance, Bacterial; D018432:Drug Resistance, Multiple; D019075:Electrophoresis, Capillary; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D006801:Humans; D013058:Mass Spectrometry; D019081:O Antigens / Q000032:analysis* / Q000737:chemistry; D011552:Pseudomonas Infections / Q000453:epidemiology* / Q000209:etiology; D011550:Pseudomonas aeruginosa / Q000737:chemistry* / Q000187:drug effects
chemical_list: D000464:Alginates; D000900:Anti-Bacterial Agents; D006603:Hexuronic Acids; D019081:O Antigens; D020723:Glucuronic Acid