title: Butyrylcholinesterase activity and mortality risk in hemodialysis patients: comparison to hsCRP and albumin.
abstract: OBJECTIVE
  To test the prediction power of butyrylcholinesterase (BuChE) activity for mortality risk in hemodialysis patients during 12 months follow-up, and made comparison to hsCRP and albumin.
  
  
  METHODS
  The study enrolled 62 patients, aged 31-79 years. Serum BuChE, high-sensitivity C-reactive protein (hsCRP) and albumin were measured after 1, 3, 9 and 12 months of dialysis. The Kaplan-Meier survival curves were employed in mortality prediction.
  
  
  RESULTS
  BuChE was positively associated with serum albumin (r=0.318; p=0.012) and inversely related to hsCRP (r=-0.358; p=0.004). The highest mortality was in the lowest quartile of basal albumin (<38.4 g/L; p=0.027), hsCRP concentrations >8 mg/L (p=0.005), and BuChE activity in the lowest tercile of basal values (<5.92 kU/L; p=0.0041).
  
  
  CONCLUSIONS
  Our results suggest that low BuChE activity may be a nonspecific risk factor for mortality in patients who are on hemodialysis.
authors.affiliation: Institute of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, PO Box 146, 11000 Belgrade, Serbia. stmarina@EUnet.rs
authors.forename: Marina D
authors.initials: MD
authors.lastname: Stojanov
authors.forename: Dusanka M
authors.initials: DM
authors.lastname: Jovicić
authors.forename: Stevan P
authors.initials: SP
authors.lastname: Djurić
authors.forename: Marija M
authors.initials: MM
authors.lastname: Konjević
authors.forename: Zoran M
authors.initials: ZM
authors.lastname: Todorović
authors.forename: Milica S
authors.initials: MS
authors.lastname: Prostran
mesh_terms: D000328:Adult; D000368:Aged; D002091:Butyrylcholinesterase / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012307:Risk Factors; D012709:Serum Albumin / Q000378:metabolism*
chemical_list: D012709:Serum Albumin; D002097:C-Reactive Protein; D002091:Butyrylcholinesterase