title: Iatrogenic Cushing syndrome after epidural triamcinolone injections in an HIV type 1-infected patient receiving therapy with ritonavir-lopinavir.
abstract: We report the first case of a human immunodeficiency virus type 1 (HIV-1)-infected individual receiving combination antiretroviral therapy, which included ritonavir, who developed Cushing syndrome with profound complications after epidural triamcinolone injections. This case highlights the potential of ritonavir interactions even with local injections of a corticosteroid.
authors.affiliation: Clinical Parasitology Unit and Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. ramanathanr@niaid.nih.gov
authors.forename: Roshan
authors.initials: R
authors.lastname: Ramanathan
authors.forename: Alice K
authors.initials: AK
authors.lastname: Pau
authors.forename: Kristin H
authors.initials: KH
authors.lastname: Busse
authors.forename: Marina
authors.initials: M
authors.lastname: Zemskova
authors.forename: Lynnette
authors.initials: L
authors.lastname: Nieman
authors.forename: Richard
authors.initials: R
authors.lastname: Kwan
authors.forename: Jean H
authors.initials: JH
authors.lastname: Hammer
authors.forename: JoAnn M
authors.initials: JM
authors.lastname: Mican
authors.forename: Frank
authors.initials: F
authors.lastname: Maldarelli
mesh_terms: D000328:Adult; D003480:Cushing Syndrome; D004347:Drug Interactions; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D015497:HIV-1 / Q000302:isolation & purification; D006801:Humans; D007049:Iatrogenic Disease; D061466:Lopinavir; D008297:Male; D011744:Pyrimidinones / Q000627:therapeutic use*; D019438:Ritonavir / Q000627:therapeutic use*; D014221:Triamcinolone / Q000008:administration & dosage* / Q000009:adverse effects*
chemical_list: D011744:Pyrimidinones; D014221:Triamcinolone; D061466:Lopinavir; D019438:Ritonavir