Multiple paragangliomata of the lungs and temporal bone.
We report the case of a 71-year-old woman with multiple benign lung paragangliomata and a benign glomus jugulare paraganglioma in one temporal bone that mimicked a malignancy. The patient's lung lesions did not regress with chemotherapy. Subsequent histologic markers suggested several very slowly dividing tumors. We review the patient's medical course and pathology from both sites. A finding of multiple lung paragangliomata should raise the suspicion of a multicentric rather than malignant tumor. Before any chemotherapeutic regimen is initiated, a thorough physical examination of the head and neck should be performed, and biopsy material should be tested for markers of cell division.
Sattar
Husain A
HA
Department of Pathology, University of Chicago Hospitals, MC 1035, Chicago, IL 60637, USA.
Yang
Dorise L
DL
Husain
Aliya N
AN
Redleaf
Miriam I
MI
Dayal
Vijay S
VS
D000368:Aged; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000601:surgery; D010236:Paraganglioma, Extra-Adrenal / Q000473:pathology* / Q000601:surgery; D012888:Skull Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000601:surgery; D013701:Temporal Bone / Q000473:pathology* / Q000601:surgery