title: Effect of the initial dose of foot-and-mouth disease virus on the early viral dynamics within pigs.
abstract: This paper investigates the early viral dynamics of foot-and-mouth disease (FMD) within infected pigs. Using an existing within-host model, we investigate whether individual variation can be explained by the effect of the initial dose of FMD virus. To do this, we consider the experimental data on the concentration of FMD virus genomes in the blood (viral load). In this experiment, 12 pigs were inoculated with one of three different doses of FMD virus: low; medium; or high. Measurements of the viral load were recorded over a time course of approximately 11 days for every 8 hours. The model is a set of deterministic differential equations with the following variables: viral load; virus in the interstitial space; and the proportion of epithelial cells available for infection, infected and uninfected. The model was fitted to the data for each animal individually and also simultaneously over all animals varying only the initial dose. We show that the general trend in the data can be explained by varying only the initial dose. The higher the initial dose the earlier the development of a detectable viral load.
authors.affiliation: Epidemiology Group, Centre for Infectious Diseases, Ashworth Laboratories, Kings Buildings, Mains Road, University of Edinburgh, Edinburgh, UK. richard.howey@ed.ac.uk
authors.forename: Richard
authors.initials: R
authors.lastname: Howey
authors.forename: Melvyn
authors.initials: M
authors.lastname: Quan
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Savill
authors.forename: Louise
authors.initials: L
authors.lastname: Matthews
authors.forename: Søren
authors.initials: S
authors.lastname: Alexandersen
authors.forename: Mark
authors.initials: M
authors.lastname: Woolhouse
mesh_terms: D000818:Animals; D003198:Computer Simulation; D005536:Foot-and-Mouth Disease / Q000821:virology*; D029544:Foot-and-Mouth Disease Virus / Q000472:pathogenicity* / Q000502:physiology*; D008954:Models, Biological; D013552:Swine / Q000821:virology*; D013553:Swine Diseases / Q000821:virology*; D019562:Viral Load