title: Ceramide and cerebrosides from the octocoral Sarcophyton ehrenbergi.
abstract: Chemical investigation of the octocoral Sarcophyton ehrenbergi, collected at the Dongsha Islands, Taiwan, has led to the isolation of a known ceramide (1) and two new cerebrosides, sarcoehrenosides A (2) and B (4), along with three known cerebrosides (3, 5, and 6). The structures of the new compounds were established by spectroscopic and chemical methods. Sarcoehrenoside A (2) differs from previously known marine cerebrosides in that it possesses a rare alpha-glucose moiety. Compounds 1-6 were evaluated for antimicrobial activity against a small panel of bacteria and for anti-inflammatory activity using RAW 264.7 macrophages.
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan, Republic of China.
authors.forename: Shi-Yie
authors.initials: SY
authors.lastname: Cheng
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Wen
authors.forename: Shu-Fen
authors.initials: SF
authors.lastname: Chiou
authors.forename: Chung-Wei
authors.initials: CW
authors.lastname: Tsai
authors.forename: Shang-Kewi
authors.initials: SK
authors.lastname: Wang
authors.forename: Chi-Hsin
authors.initials: CH
authors.lastname: Hsu
authors.forename: Chang-Feng
authors.initials: CF
authors.lastname: Dai
authors.forename: Michael Y
authors.initials: MY
authors.lastname: Chiang
authors.forename: Wei-Hsien
authors.initials: WH
authors.lastname: Wang
authors.forename: Chang-Yih
authors.initials: CY
authors.lastname: Duh
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002518:Ceramides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002554:Cerebrosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D021902:Enterobacter aerogenes / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012477:Salmonella enteritidis / Q000187:drug effects; D012706:Serratia marcescens / Q000187:drug effects; D012764:Shigella sonnei / Q000187:drug effects; D015008:Yersinia enterocolitica / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D002518:Ceramides; D002554:Cerebrosides