Coordinating innate immune cells to optimize microbial killing.
The mechanisms underlying innate immune cell trafficking and activation during infection remain incompletely defined. In this issue of Immunity, Kang et al. (2008) begin to reveal the cytokine and chemokine cascades that coordinate cellular responses induced by microbial pathogens.
Serbina
Natalya V
NV
Infectious Disease Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, Immunology Program, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10021, USA.
Pamer
Eric G
EG
D000818:Animals; D001424:Bacterial Infections / Q000276:immunology* / Q000378:metabolism; D001427:Bacterial Toxins / Q000276:immunology* / Q000378:metabolism; D016207:Cytokines / Q000276:immunology* / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D006360:Heat-Shock Proteins / Q000276:immunology* / Q000378:metabolism; D006460:Hemolysin Proteins / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D009000:Monocytes / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D053594:Myeloid Differentiation Factor 88 / Q000172:deficiency / Q000378:metabolism*
D001427:Bacterial Toxins; D016207:Cytokines; D006360:Heat-Shock Proteins; D006460:Hemolysin Proteins; C507780:Myd88 protein, mouse; D053594:Myeloid Differentiation Factor 88; C038705:hlyA protein, Listeria monocytogenes