Prostate apoptosis response 4 gene is not associated with methamphetamine-use disorder in the Japanese population.
Abnormal intracellular signaling molecules in dopamine signal transduction are thought to be associated with the pathophysiology of methamphetamine (METH)-use disorder. A recent study reported that a new intracellular protein, prostate apoptosis response 4 (Par-4), plays a critical role in dopamine 2 receptor signaling. We therefore analyzed the association between the Par-4 gene (PAWR) and METH-use disorder in a Japanese population (191 patients with METH-use disorder and 466 healthy controls). Using the recommended "gene-based" association analysis, we selected five tagging SNPs in PAWR from the HapMap database. No significant allele/genotype-wise or haplotype-wise association was found between PAWR and METH-use disorder. These results suggest that PAWR does not play a major role in METH-use disorders in the Japanese population.
Kishi
Taro
T
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan. taroh@fujita-hu.ac.jp
Ikeda
Masashi
M
Kitajima
Tsuyoshi
T
Yamanouchi
Yoshio
Y
Kinoshita
Yoko
Y
Kawashima
Kunihiro
K
Inada
Toshiya
T
Harano
Mutsuo
M
Komiyama
Tokutaro
T
Hori
Toru
T
Yamada
Mitsuhiko
M
Iyo
Masaomi
M
Sora
Ichiro
I
Sekine
Yoshimoto
Y
Ozaki
Norio
N
Ujike
Hiroshi
H
Iwata
Nakao
N
D000328:Adult; D019969:Amphetamine-Related Disorders / Q000235:genetics*; D051017:Apoptosis Regulatory Proteins / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
D051017:Apoptosis Regulatory Proteins; C101296:prostate apoptosis response-4 protein; D008694:Methamphetamine