Regional homogeneity in depression and its relationship with separate depressive symptom clusters: a resting-state fMRI study.
BACKGROUND
Using a newly reported regional homogeneity (ReHo) approach, we were to explore the features of brain activity of patients with major depressive disorder (MDD) in resting state, and further to examine the relationship between abnormal brain activity of depressed patients and specific symptom clusters derived from ratings on the Hamilton Rating Scale for Depression (HRSD).


METHODS
22 patients with MDD and 22 gender-, age-, and education-matched healthy subjects participated in the fMRI scans.


RESULTS



CONCLUSIONS
The influence of antidepressant medication to the brain activity of depressed patients was not fully excluded.


CONCLUSIONS
Our findings indicated abnormal brain activity was distributed extensively in depressed patients during resting state, and some symptom domains of depression are separately related to specific abnormal patterns of brain activity.
Yao
Zhijian
Z
Department of Radiology, Zhong Da Hospital, School of Clinical Medicine, Southeast University, Nanjing, Jiangsu, China. yaozhijian@yahoo.cn
Wang
Li
L
Lu
Qing
Q
Liu
Haiyan
H
Teng
Gaojun
G
D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D016022:Case-Control Studies; D003863:Depression / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D055815:Young Adult
D000928:Antidepressive Agents