title: Rifalazil and derivative compounds show potent efficacy in a mouse model of H. pylori colonization.
abstract: The rifamycin rifalazil (RFZ), and derivatives (NCEs) were efficacious in a mouse model of Helicobacter pylori colonization. Select NCEs were more active in vitro and showed greater efficacy than RFZ. A systemic component contributes to efficacy.
authors.affiliation: ActivBiotics, Inc, Lexington, MA 02421, USA. drothstein@rcn.com
authors.forename: David M
authors.initials: DM
authors.lastname: Rothstein
authors.forename: Steve
authors.initials: S
authors.lastname: Mullin
authors.forename: Klari
authors.initials: K
authors.lastname: Sirokman
authors.forename: Karen L
authors.initials: KL
authors.lastname: Söndergaard
authors.forename: Starrla
authors.initials: S
authors.lastname: Johnson
authors.forename: Judith K
authors.initials: JK
authors.lastname: Gwathmey
authors.forename: John
authors.initials: J
authors.lastname: van Duzer
authors.forename: Christopher K
authors.initials: CK
authors.lastname: Murphy
mesh_terms: D000818:Animals; D000904:Antibiotics, Antitubercular / Q000494:pharmacology*; D004195:Disease Models, Animal; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000382:microbiology; D016480:Helicobacter pylori / Q000187:drug effects / Q000254:growth & development*; D051379:Mice; D008810:Mice, Inbred C57BL; D008826:Microbial Sensitivity Tests; D012294:Rifamycins / Q000494:pharmacology*
chemical_list: D000904:Antibiotics, Antitubercular; D012294:Rifamycins; C068980:KRM 1648