title: Activated protein C resistance, factor V Leiden and assessment of thrombotic risk.
abstract: Venous thromboembolism comprises deep vein thrombosis (DVT) and pulmonary embolism (PE). Acute venous thromboembolism (VTE) is a serious and potentially fatal disorder which often complicates the course of hospitalized patients, but also affects ambulatory and otherwise healthy people. The annual incidence of venous thromboembolism is 1 to 2 cases per 1000 person and the risk of the disorder rises exponentially with age, from an annual rate of less than 5 per 100,000 children to greater than 400 per 100,000 adults older than 80 years.
authors.affiliation: National Centre for Hereditary Coagulation Disorders, St James's Hospital, James's Street, Dublin. rgilmore@stjames.ie
authors.forename: R
authors.initials: R
authors.lastname: Gilmore
authors.forename: M
authors.initials: M
authors.lastname: Doyle
authors.forename: F
authors.initials: F
authors.lastname: Holden
authors.forename: B
authors.initials: B
authors.lastname: White
authors.forename: J
authors.initials: J
authors.lastname: O'Donnell
mesh_terms: D020016:Activated Protein C Resistance / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D005165:Factor V; D006801:Humans; D008297:Male; D011655:Pulmonary Embolism / Q000209:etiology*; D018570:Risk Assessment; D012307:Risk Factors; D054556:Venous Thromboembolism / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D020246:Venous Thrombosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D055815:Young Adult
chemical_list: D000925:Anticoagulants; C095381:factor V Leiden; D005165:Factor V