title: Transnasal endoscopy with narrow-band imaging and Lugol staining to screen patients with head and neck cancer whose condition limits oral intubation with standard endoscope (with video).
abstract: BACKGROUND
  Early detection of esophageal cancer in patients with head and neck cancers may alter treatment planning and improve survival. However, standard endoscopic screening is not feasible for some patients with tumor-related airway compromise or postirradiation trismus.
  
  
  OBJECTIVE
  To evaluate a novel, sequential approach by integrating ultrathin endoscopy with narrow-band imaging and Lugol chromoendoscopy.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  Single center in Taiwan.
  
  
  METHODS
  Forty-four consecutive patients with transoral difficulty screened for synchronous or metachronous esophageal cancer.
  
  
  METHODS
  Sensitivity, specificity, and accuracy in the detection of mucosal high-grade neoplasia or invasive cancer.
  
  
  RESULTS
  Fifty-four endoscopic interpretations were obtained, and 11 mucosal high-grade neoplasia and 7 invasive cancers were confirmed by histology. The mean examination time was 19.4 minutes (range 7.9-35.2 minutes), and all patients tolerated the procedure well. Sensitivity, specificity, and accuracy (with 95% CI) were 55.6% (95% CI, 33.5%-75.6%), 97.2% (95% CI, 85.8%-99.3%), and 83.3% (95% CI, 71.2%-90.9%), respectively, for standard endoscopy; 88.9% (95% CI, 66.9%-96.6%), 97.2% (95% CI, 85.8%-99.3%), and 94.4% (95% CI, 84.9%-97.9%), respectively, with the adjunct of narrow-band imaging; and 88.9% (95% CI, 66.9%-96.6%), 72.2% (95% CI, 55.9%-84.1%), and 77.8% (95% CI, 64.9%-86.8%), respectively, with the adjunct of Lugol chromoendoscopy. When we integrated all interpretations on the basis of the sequential approach, the estimated probability of false-negative findings was 1.2% (95% CI, 0.1%-4.6%).
  
  
  CONCLUSIONS
  Inherent shortcomings of ultrathin endoscopy, such as its resolution, light source, and lack of magnification.
  
  
  CONCLUSIONS
  The use of ultrathin endoscopy in a sequential approach for multimodal detection is feasible in patients with transoral difficulty and substantially increases the detection rate of synchronous or metachronous neoplasms.
authors.affiliation: Department of Internal Medicine, National Taiwan University Hospital, Division of Biostatistics, Taipei, Taiwan.
authors.forename: Yi-Chia
authors.initials: YC
authors.lastname: Lee
authors.forename: Cheng-Ping
authors.initials: CP
authors.lastname: Wang
authors.forename: Chien-Chuan
authors.initials: CC
authors.lastname: Chen
authors.forename: Han-Mo
authors.initials: HM
authors.lastname: Chiu
authors.forename: Jenq-Yuh
authors.initials: JY
authors.lastname: Ko
authors.forename: Pei-Jen
authors.initials: PJ
authors.lastname: Lou
authors.forename: Tsung-Lin
authors.initials: TL
authors.lastname: Yang
authors.forename: Hsin-Yi
authors.initials: HY
authors.lastname: Huang
authors.forename: Ming-Shiang
authors.initials: MS
authors.lastname: Wu
authors.forename: Jaw-Town
authors.initials: JT
authors.lastname: Lin
authors.forename: Tony
authors.initials: T
authors.lastname: Hsiu-Hsi Chen
authors.forename: Hsiu-Po
authors.initials: HP
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001003:Anal Canal; D004396:Coloring Agents; D003430:Cross-Sectional Studies; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D004938:Esophageal Neoplasms / Q000473:pathology*; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D007454:Iodides; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014741:Video Recording
chemical_list: D004396:Coloring Agents; D007454:Iodides; C010389:Lugol's solution