Effect of food on the pharmacokinetic profile of trans-resveratrol.
OBJECTIVE
It has been postulated that trans-resveratrol may act as an antioxidant, cardioprotective, neuroprotective and cancer chemopreventive agent. The objective of this study was to investigate the effect of food on the bioavailability of trans-resveratrol following oral administration.


METHODS
Single-centre, open-label, randomized, 2-way crossover study on 24 healthy subjects. The study consisted of two consecutive treatment periods separated by a washout of 7 days or more. On each of the study periods subjects were administered a single-dose of 400 mg of trans-resveratrol following either a standard high fat content meal or 8 hs of fasting.


RESULTS
There was a large interindividual variability in the trans-resveratrol pharmacokinetic parameters. Mean +/- SD maximum plasma concentration (Cmax) was 42.2 +/- 36.6 ng/ml in fed and 47.3 +/- 30.0 ng/ml in fasting conditions. Median time to Cmax (tmax) was 2.0 h in fed and 0.5 h in fasting (p < 0.0001). The fed/fasting geometric mean ratio (GMR) and 90% confidence interval (90% CI) were 79.4 and 53.8, 117.0% for Cmax, and 106.0 and 86.8, 128.0% for the area under the plasma concentration-time curve (AUC0- yen). The 90% CI for the GMR of AUC0- yen and Cmax fall outside the usual bioequivalence acceptance range of 80, 125%, but that of AUC0- yen was close to the bioequivalence standard.


CONCLUSIONS
The rate of absorption of trans-resveratrol following an oral 400 mg single-dose was significantly delayed by the presence of food, as reflected by Cmax and tmax. However, the extent of absorption, as reflected by AUC- yen, was not affected in a relevant way.
Vaz-da-Silva
M
M
Department of Research and Development, BIAL, S. Mamede do Coronado, Portugal.
Loureiro
A I
AI
Falcao
A
A
Nunes
T
T
Rocha
J-F
JF
Fernandes-Lopes
C
C
Soares
E
E
Wright
L
L
Almeida
L
L
Soares-da-Silva
P
P
D000284:Administration, Oral; D000328:Adult; D000975:Antioxidants / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001682:Biological Availability; D016001:Confidence Intervals; D018592:Cross-Over Studies; D005215:Fasting / Q000378:metabolism; D005260:Female; D005502:Food; D006207:Half-Life; D006801:Humans; D008297:Male; D000077185:Resveratrol; D013267:Stilbenes / Q000097:blood / Q000493:pharmacokinetics*; D014920:Wine
D000975:Antioxidants; D013267:Stilbenes; D000077185:Resveratrol