[New predictive factors for chemosensitivity of breast cancers].
Considering both the clinical and molecular heterogeneity of breast cancers, one can easily conceive that all tumours are not equally sensitive to the different chemotherapy agents or regimens used. Thus, the identification of predictive markers of chemosensitivity should be considered as a research priority and we analyse here this question in two parts: (1) identification of predictive markers of general chemosensitivity, which means that a tumour is sensitive to any chemotherapy; (2) identification of predictive markers of specific chemotherapy which means that a tumour is sensitive to a specific cytostatic class or to a specific regimen. We will address these two aspects and will summarise ongoing trials and recently published data. These studies suggest the predictive value of biological markers either considered as single molecular markers (hormone receptors, HER2, TOPO2alpha, p53) or as multiple markers combined in so-called "signatures".
Bonnefoi
Hervé
H
Institut Bergonié et université de Bordeaux-II, Bordeaux.
de Cremoux
Patricia
P
D000951:Antigens, Neoplasm / Q000235:genetics; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics; D004250:DNA Topoisomerases, Type II / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D005260:Female; D020869:Gene Expression Profiling; D018734:Genes, erbB-2 / Q000235:genetics; D016158:Genes, p53 / Q000235:genetics; D005819:Genetic Markers; D006728:Hormones / Q000378:metabolism; D006801:Humans; D011956:Receptors, Cell Surface / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D000951:Antigens, Neoplasm; D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D005819:Genetic Markers; D006728:Hormones; D011956:Receptors, Cell Surface; D016159:Tumor Suppressor Protein p53; D004250:DNA Topoisomerases, Type II