title: Sesquiterpene lactones from the endemic Cape Verdean Artemisia gorgonum.
abstract: Leaves and flowers of Artemisia gorgonum (Asteraceae) collected in Fogo, Cape Verde islands, were phytochemically investigated and resulted in isolation and characterization of three guaianolides 1, 2, 5, and a secoguainolide 4, in addition to eight known guaianolides 6-11 and two known germacranolides 12, 13. Structures were elucidated by 1D and 2D NMR experiments. Careful examination of the (13)C NMR spectrum led to revision of the structure of a previously described guaianolide from 2 to 3. Most compounds exhibited mild antiplasmodial activities, ridentin (13) being the most interesting with an IC(50) of 3.8+/-0.7microgml(-1) against Plasmodium falciparum FcB1 and weak cytotoxicity in a vero cell line (IC(50) 71.0+/-3.9microgml(-1)).
authors.affiliation: Université de Nice-Sophia Antipolis, Laboratoire de Chimie des Molécules Bioactives et des Arômes, UMR 6001 CNRS, Faculté des Sciences, Nice, France.
authors.forename: Risoleta
authors.initials: R
authors.lastname: Ortet
authors.forename: Soizic
authors.initials: S
authors.lastname: Prado
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Mouray
authors.forename: Olivier P
authors.initials: OP
authors.lastname: Thomas
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology; D019306:Artemisia / Q000737:chemistry* / Q000378:metabolism; D055726:Cabo Verde; D002522:Chlorocebus aethiops; D035264:Flowers / Q000737:chemistry / Q000378:metabolism; D007783:Lactones / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry / Q000378:metabolism; D010963:Plasmodium falciparum / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry* / Q000378:metabolism; D014709:Vero Cells
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000995:Antitubercular Agents; D007783:Lactones; D012717:Sesquiterpenes