title: A prospective observational study of changes in renal function and cardiovascular risk following living kidney donation.
abstract: The effect of unilateral nephrectomy on the cardiovascular risk profile of living kidney donors has not been prospectively studied. We performed an observational cohort study of 58 living donors to 6 months postdonation for changes in 24-hr ambulatory blood pressure profiles, renal function, urine protein excretion, body mass index, glucose tolerance, and fasting lipid profiles. The 24-hr systolic blood pressure average and night-day ratio were unchanged from pre- to postdonation (118.9+/-11 vs. 118.1+/-14 mm Hg, P=0.77; 0.87+/-0.07 vs. 0.87+/-0.09, P=0.68, respectively). Estimated glomerular filtration rate declined from 91.9+/-16 to 61.6+/-12 mL/min/1.73 m2 (P<0.0001). Protein excretion, body mass index, glucose, and lipids were unchanged. No significant differences were noted between dippers and nondippers either pre- or postdonation. In summary, living kidney donation in the short term is safe. We suggest further observation of individuals with lower glomerular filtration rate for possible increased cardiovascular risk factors in the future.
authors.affiliation: Division of Nephrology, University of Toronto, St. Michael's Hospital, Toronto, ON, Canada. prasadr@smh.toronto.on.ca
authors.forename: G V Ramesh
authors.initials: GV
authors.lastname: Prasad
authors.forename: Deborah
authors.initials: D
authors.lastname: Lipszyc
authors.forename: Michael
authors.initials: M
authors.lastname: Huang
authors.forename: Michelle M
authors.initials: MM
authors.lastname: Nash
authors.forename: Lindita
authors.initials: L
authors.lastname: Rapi
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D002320:Cardiovascular Physiological Phenomena; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000502:physiology*; D016030:Kidney Transplantation; D008055:Lipids / Q000097:blood; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy / Q000009:adverse effects*; D011446:Prospective Studies; D011507:Proteinuria / Q000503:physiopathology; D012307:Risk Factors
chemical_list: D001786:Blood Glucose; D008055:Lipids