Anti CagA antibody among patients with non-cardia gastric cancer in comparison with non-ulcer dyspepsia in an area with high incidence of gastric cancer.
OBJECTIVE
To evaluate the correlation between anti CagA antibody (Ab) and presence of gastric cancer.


METHODS
In a descriptive cross-sectional study during October 2003 to October 2005, in the Gastrointestinal Subspeciality Center in Razi Hospital, Rasht, Iran, we assessed anti-Helicobacter Ab immunoglobulin G (IgG) and anti CagA Ab IgG by the enzyme-linked immunosorbent assay (ELISA) method in 52 patients with gastric adenocarcinoma and 57 patients with nonulceric dyspepsia (NUD).


RESULTS
Among 52 patients with gastric cancer, anti-Helicobacter pylori Ab was negative in 13 (25%) and positive in 39 persons (75%). Among 57 patients with NUD, anti-Helicobacter pylori Ab was negative in 5 (8.5%) and positive in 52 patients (91.2%) (p=0.043). This significant difference did not remain after logistic regression for adjustment of confounders (p=0.068). The CagA Ab was positive in 22 (42.3%) patients with cancer and 32 (56.1%) of the NUD group. There was no difference in this regard before (p=0.212) and after (p=0.131) logistic regression analysis.


CONCLUSIONS
Anti CagA Ab does not have a significant value as an independent predictive factor in gastric adenocarcinoma.
Mansour-Ghanaei
Fariborz
F
Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences, Razi Hospital, Sardar-Jangle Ave, PO Box 41448-95655, Rasht, Iran. ghanaei@gums.ac.ir
Abbasi
Roxana
R
Joukar
Farahnaz
F
Besharati
Sepiedeh
S
Askari-Jirhandeh
Neda
N
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000097:blood*; D000942:Antigens, Bacterial / Q000276:immunology*; D001426:Bacterial Proteins / Q000276:immunology*; D004415:Dyspepsia / Q000276:immunology*; D005260:Female; D006801:Humans; D015994:Incidence; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000276:immunology*
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C080866:cagA protein, Helicobacter pylori