Epidemiological investigation and glycotyping of clinical Pseudomonas aeruginosa isolates from patients with cystic fibrosis by mass spectrometry: association with multiple drug resistance.
The aim of the present investigation was to develop a novel approach for rapid identification and differentiation of Pseudomonas aeruginosa clones from Canadian cystic fibrosis patients by capillary electrophoresis-mass spectrometry. We screened P. aeruginosa isolates for lipopolysaccharide structure and presence/absence of alginate and correlated these findings with antibiotic resistance patterns.
Altman
Eleonora
E
Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada. Eleonora.altman@nrc-cnrc.gc.ca
Wang
Zhan
Z
Aaron
Shawn D
SD
Liu
Xin
X
Vandemheen
Katherine L
KL
Ferris
Wendy
W
Giesbrecht
Tracy
T
Li
Jianjun
J
D000464:Alginates; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003550:Cystic Fibrosis / Q000150:complications / Q000382:microbiology*; D024881:Drug Resistance, Bacterial; D018432:Drug Resistance, Multiple; D019075:Electrophoresis, Capillary; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D006801:Humans; D013058:Mass Spectrometry; D019081:O Antigens / Q000032:analysis* / Q000737:chemistry; D011552:Pseudomonas Infections / Q000453:epidemiology* / Q000209:etiology; D011550:Pseudomonas aeruginosa / Q000737:chemistry* / Q000187:drug effects
D000464:Alginates; D000900:Anti-Bacterial Agents; D006603:Hexuronic Acids; D019081:O Antigens; D020723:Glucuronic Acid