Response of oxidative stress markers and antioxidant parameters to an 8-week aerobic physical activity program in healthy, postmenopausal women.
The aim of the study was to assess the influence of an 8-week aerobic physical activity program on oxidative stress markers, antioxidant parameters, and selected metabolic parameters in healthy, postmenopausal women. The study was carried out in a group of 41 healthy women (mean age 65 years) participating in an 8-week cycle ergometer physical workout of moderate intensity. Before and after completing the training program, the following parameters were assessed: total antioxidant status (TAS) and concentrations of thiobarbituric acid reactive substances (TBARS) in plasma, serum levels of antibodies against oxidatively modified low-density lipoproteins (LDL) (oLAB), serum concentrations of glucose, high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), insulin, and reduced glutathione (GSH) concentrations in red blood cells (RBC). Atherogenic index of plasma (AIP) and insulin resistance index (HOMA(IR)) were calculated. The 8-week aerobic physical activity program resulted in significant decrease (p<0.01) in serum glucose and LDL-cholesterol (LDL-C) levels, plasma TBARS concentrations (p<0.05), and in significant decrease of HOMA(IR) (p<0.01). TAS of plasma and GSH concentrations in RBC increased significantly (p<0.01) over the study period. The results show that an 8-week aerobic training enhanced insulin sensitivity, and improved the balance between oxidants and antioxidants in healthy, postmenopausal women.
Karolkiewicz
Joanna
J
University School of Physical Education, Królowej Jadwigi str. 27/39, 61-871 Poznań, Poland. karolkiewicz@awf.poznan.pl
Michalak
Edyta
E
Pospieszna
Barbara
B
Deskur-Smielecka
Ewa
E
Nowak
Alicja
A
Pilaczyńska-Szcześniak
Łucja
Ł
D000886:Anthropometry; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers; D008078:Cholesterol, LDL / Q000097:blood; D015444:Exercise; D005260:Female; D005978:Glutathione / Q000097:blood; D006304:Health Status; D006801:Humans; D007333:Insulin Resistance; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D017698:Postmenopause; D016730:Program Development; D013858:Thiobarbiturates / Q000097:blood
D000975:Antioxidants; D015415:Biomarkers; D008078:Cholesterol, LDL; D013858:Thiobarbiturates; D005978:Glutathione; C029684:thiobarbituric acid