title: Novel oxime and oxime ether derivatives of 12,14-dichlorodehydroabietic acid: design, synthesis, and BK channel-opening activity.
abstract: Oxime ether derivatives of the benzylic ketone of 12,14-dichlorodehydroabietic acid (diCl-DHAA, 4b) were synthesised, and their BK channel-opening activity was evaluated in an assay system of CHO-K1 cells expressing hBKalpha channels. Oxime ether structure on the B ring of diCl-DHAA significantly increased the BK channel-opening activity.
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Yong-Mei
authors.initials: YM
authors.lastname: Cui
authors.forename: Eriko
authors.initials: E
authors.lastname: Yasutomi
authors.forename: Yuko
authors.initials: Y
authors.lastname: Otani
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshinaga
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Ido
authors.forename: Kohei
authors.initials: K
authors.lastname: Sawada
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Kawahata
authors.forename: Kentaro
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Ohwada
mesh_terms: D045784:Abietanes / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D016466:CHO Cells; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D006224:Cricetinae; D003412:Cricetulus; D018360:Crystallography, X-Ray / Q000379:methods; D015195:Drug Design; D004987:Ethers / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry; D051036:Large-Conductance Calcium-Activated Potassium Channels / Q000737:chemistry*; D008956:Models, Chemical; D008968:Molecular Conformation; D010091:Oximes / Q000737:chemistry*; D018408:Patch-Clamp Techniques
chemical_list: C119118:12,14-dichlorodehydroabietic acid; D045784:Abietanes; D004987:Ethers; D051036:Large-Conductance Calcium-Activated Potassium Channels; D010091:Oximes; D006859:Hydrogen