Association between serum soluble CD30 and serum creatinine before and after renal transplantation.
OBJECTIVE
There is increasing evidence that circulating levels of soluble CD30 (sCD30) may represent a biomarker for outcome in kidney transplantation. The aim of this study was to measure the pre- and posttransplantation serum levels of sCD30 in cadaveric kidney transplant recipients and correlate them with serum creatinine.


METHODS
Serum sCD30 was measured by a commercial enzyme-linked immunosorbent assay (ELISA) from prospective samples of 38 kidney allograft recipients serially transplanted at our center. Samples were collected at day 0 pretransplantation and at months 6, 12, 18, and 24 posttransplantation. We also studied sera from 29 patients with chronic kidney disease (CKD) at different stages of the K/DOQI guidelines, as a control group.


RESULTS
Serum levels of sCD30 decreased significantly in samples posttransplantation compared with pretransplantation. The significant decrease after transplantation may be related to the improvement in renal function since we observed a significant correlation between serum levels of sCD30 and creatinine (sCr) at all times of the study. In addition, the patients with chronic renal failure showed a significant association between serum sCD30 and sCr (r = .454; P = .013).


CONCLUSIONS
Our results did not suggest that the measurement of sCD30 may be used as a valuable biomarker in renal transplantation. Increased levels may be related to a decrease in its renal elimination.
López-Hoyos
M
M
Servicio de Inmunología, Hospital Universitario Marqués de Valdecilla-IFIMAV, Santander, Spain. inmlhm@humv.es
San Segundo
D
D
Benito
M J
MJ
Fernández-Fresnedo
G
G
Ruiz
J C
JC
Rodrigo
E
E
Gómez-Alamillo
C
C
Benito
A
A
Arias
M
M
D015703:Antigens, CD / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002102:Cadaver; D003404:Creatinine / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000097:blood / Q000453:epidemiology; D006801:Humans; D017730:Ki-1 Antigen / Q000097:blood*; D016030:Kidney Transplantation / Q000502:physiology*; D014019:Tissue Donors; D016896:Treatment Outcome
D015703:Antigens, CD; D015415:Biomarkers; D017730:Ki-1 Antigen; D003404:Creatinine