title: A look inside the diabetic brain: Contributors to diabetes-induced brain aging.
abstract: Central nervous system (CNS) complications resulting from diabetes is a problem that is gaining more acceptance and attention. Recent evidence suggests morphological, electrophysiological and cognitive changes, often observed in the hippocampus, in diabetic individuals. Many of the CNS changes observed in diabetic patients and animal models of diabetes are reminiscent of the changes seen in normal aging. The central commonalities between diabetes-induced and age-related CNS changes have led to the theory of advanced brain aging in diabetic patients. This review summarizes the findings of the literature as they relate to the relationship between diabetes and dementia and discusses some of the potential contributors to diabetes-induced CNS impairments.
authors.affiliation: Department of Pharmacology, Physiology and Neuroscience University of South Carolina, School of Medicine, Columbia, SC 29208, USA.
authors.forename: Shayna A
authors.initials: SA
authors.lastname: Wrighten
authors.forename: Gerardo G
authors.initials: GG
authors.lastname: Piroli
authors.forename: Claudia A
authors.initials: CA
authors.lastname: Grillo
authors.forename: Lawrence P
authors.initials: LP
authors.lastname: Reagan
mesh_terms: D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D003072:Cognition Disorders / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D005947:Glucose / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007328:Insulin / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D016875:tau Proteins / Q000378:metabolism
chemical_list: D007328:Insulin; D016875:tau Proteins; D005947:Glucose