title: Vasodilatation effect of farnesylacetones, active constituents of Sargassum siliquastrum, on the basilar and carotid arteries of rabbits.
abstract: Two farnesylacetones, 311 and 312, major active constituents of Sargassum siliquastrum collected from the coast of the East Sea in Korea, showed a moderate vasodilatation effect on the basilar arteries of rabbits. Therefore, treatment with farnesylacetones 311 and 312 may selectively accelerate cerebral blood flow through dilatation of the basilar artery.
authors.affiliation: Department of Physiology, Kwandong University College of Medicine, Gangneung 210-701, Republic of Korea.
authors.forename: Byong-Gon
authors.initials: BG
authors.lastname: Park
authors.forename: Seong-Chun
authors.initials: SC
authors.lastname: Kwon
authors.forename: Gab-Man
authors.initials: GM
authors.lastname: Park
authors.forename: Jungyeob
authors.initials: J
authors.lastname: Ham
authors.forename: Woon-Seob
authors.initials: WS
authors.lastname: Shin
authors.forename: Seokjoon
authors.initials: S
authors.lastname: Lee
mesh_terms: D000818:Animals; D001488:Basilar Artery / Q000187:drug effects*; D001783:Blood Flow Velocity / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000188:drug therapy; D002339:Carotid Arteries / Q000187:drug effects*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D008956:Models, Chemical; D011817:Rabbits; D044647:Sargassum / Q000378:metabolism*; D013729:Terpenes / Q000737:chemistry*; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D013729:Terpenes; D014665:Vasodilator Agents; C014549:farnesylacetone