Myristica malabarica heals stomach ulceration by increasing prostaglandin synthesis and angiogenesis.
Earlier we had shown that on the 3 (rd) day of its administration to mice, indomethacin (18 mg kg (-1), P. O.) produced maximum stomach ulceration with a damage score of 3.46, which was reduced by a 3-day treatment with the methanol extract of Myristica malabarica (40 mg kg (-1), P. O.) and omeprazole (3 mg kg (-1), P. O.) to 0.95 and 0.82, respectively. Presently, we investigated the possible role of the test samples in modulating PG synthesis and angiogenesis for their healing action. The ulceration was found to be associated with suppression of PGE (2), VEGF and vWF VIII, and an increase in EGF and endostatin levels. Treatment with the plant extract reversed all these parameters accounting for its healing activity. However, despite providing similar healing, omeprazole did not alter these parameters.
Maity
Biswanath
B
Department of Biochemistry, Dr. B.C. Roy Post Graduate Institute of Basic Medical Sciences & IPGME&R, Kolkata, India.
Banerjee
Debashish
D
Bandyopadhyay
Sandip K
SK
Chattopadhyay
Subrata
S
D043925:Angiogenesis Inducing Agents / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D000897:Anti-Ulcer Agents / Q000494:pharmacology / Q000627:therapeutic use*; D015232:Dinoprostone / Q000096:biosynthesis*; D043169:Endostatins / Q000097:blood; D004815:Epidermal Growth Factor / Q000097:blood; D005638:Fruit; D005753:Gastric Mucosa / Q000187:drug effects; D007213:Indomethacin; D008297:Male; D051379:Mice; D026324:Myristicaceae; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D009853:Omeprazole / Q000627:therapeutic use; D010120:Oxytocics / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*; D042461:Vascular Endothelial Growth Factor A / Q000097:blood; D014841:von Willebrand Factor / Q000032:analysis
D043925:Angiogenesis Inducing Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D043169:Endostatins; D010120:Oxytocics; D010936:Plant Extracts; D042461:Vascular Endothelial Growth Factor A; D014841:von Willebrand Factor; D004815:Epidermal Growth Factor; D015232:Dinoprostone; D009853:Omeprazole; D007213:Indomethacin