Acute pancreatitis and thrombotic thrombocytopenic purpura.
Thrombotic thrombocytopenic purpura (TTP) has multiple clinical manifestations and risk factors, but the events that actually trigger acute episodes of TTP are often unclear. We describe the case of a 56-year-old woman who presented with clinical signs and symptoms of TTP and acute pancreatitis. We discuss whether pancreatitis was due to ischemic pancreatic damage caused by microvascular platelet clumping in the frame of TTP, or whether acute pancreatitis, a disorder that results in an intense systemic inflammatory response, may be a triggering event for acute episodes of TTP.
Bergmann
I P
IP
Department of Nephrology and Hypertension, Inselspital, University of Bern, Freiburgstrasse 10, CH-3010 Bern, Switzerland.
Kremer Hovinga
J A
JA
Lämmle
B
B
Peter
H J
HJ
Schiemann
U
U
D051722:ADAM Proteins / Q000172:deficiency; D000071120:ADAMTS13 Protein; D005260:Female; D006801:Humans; D008875:Middle Aged; D010195:Pancreatitis / Q000150:complications* / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D010951:Plasma Exchange; D011697:Purpura, Thrombotic Thrombocytopenic / Q000150:complications* / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D014057:Tomography, X-Ray Computed
D051722:ADAM Proteins; D000071120:ADAMTS13 Protein; C099604:ADAMTS13 protein, human