Vascular function of MGH and MGL mice, two strains which differ by a genetic variation of magnesium metabolism.
Mg deficiency is considered as a risk factor of cardiovascular disorders like hypertension and atherosclerosis. MGH and MGL mice, selected for high and low Mg status, are animal models which present variations of Mg metabolism of genetic origin. The cardiovascular functions of these mice have never been studied. In this study, the arterial blood pressure of MGH and MGL strains was measured by plethysmography. Morphology and reactivity to vasoconstrictor agents were also investigated by a pressurized and perfused system in mesenteric resistance artery. It is shown that: (1) MGH mice presented a higher plasma Mg concentration than MGL; (2) arterial blood pressure and heart rates were similar between the two groups; (3) media thickness, media cross-sectional area, and internal and external diameters were smaller in pressurized mesenteric resistance arteries from MGH mice than in those from MGL mice; (4) the vasoconstriction induced by vasopressin (but not norepinephrine) was higher in the mesenteric arteries from MGH mice than in those from MGL ones. In summary, MGH mice as compared to MGL mice present differences in arterial geometry and higher reactivity to vasopressin without repercussions on arterial blood pressure. The real repercussion of these observations on the cardiovascular system of the MGH and MGL models is at present unknown. More experiments are needed to clarify the influence of differences in Mg metabolism of genetic origin on cardiovascular function.
Grandvuillemin
Antoine
A
EA 3921 Optimisation métabolique et cellulaire, UFR Médecine-Pharmacie, Besançon, France.
Laurant
Pascal
P
Mazur
Andrzej
A
Rayssiguier
Yves
Y
Berthelot
Alain
A
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D014644:Genetic Variation; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008274:Magnesium / Q000097:blood*; D008297:Male; D008638:Mesenteric Arteries / Q000033:anatomy & histology* / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics / Q000378:metabolism; D009638:Norepinephrine / Q000494:pharmacology; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014667:Vasopressins / Q000494:pharmacology
D014662:Vasoconstrictor Agents; D014667:Vasopressins; D008274:Magnesium; D009638:Norepinephrine