A distinct role in breast cancer for two LIV-1 family zinc transporters.
Zinc, essential for normal cell growth, is tightly controlled in cells by two families of zinc transporters. The aberrant expression of zinc transporters from the LIV-1 family of ZIP (Zrt/Irt-like protein) transporters is increasingly being implicated in a variety of disease states. In the present paper, I describe a mechanism for the role of ZIP7 in the progression of breast cancer, identifying it as a new target in breast cancer. Furthermore, I document a link between another zinc transporter, LIV-1, and breast cancer metastasis, identifying it as a potential new prognostic indicator of breast cancer spread.
Taylor
Kathryn M
KM
Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Cathays Park, Cardiff, UK. Taylorkm@cardiff.ac.uk
D001943:Breast Neoplasms / Q000378:metabolism*; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism*; D027682:Cation Transport Proteins / Q000378:metabolism; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D004967:Estrogens / Q000494:pharmacology; D006801:Humans; D015032:Zinc / Q000378:metabolism
D002352:Carrier Proteins; D027682:Cation Transport Proteins; D004967:Estrogens; C102227:SLC39A7 protein, human; C017800:zinc-binding protein; D015032:Zinc