Antioxidant therapy in Alzheimer's disease: theory and practice.
Alzheimer disease treatment has yet to yield a successful therapy that addresses the source of the damage found in brains. Of the varied proposed theories of AD etiology, reactive oxygen species (ROS) generation is cited as a common factor. Efforts to reduce the pathology associated with ROS via antioxidants therefore offer new hope to patients suffering from this devastative disease.
Aliev
Gjumrakch
G
Department of Biology, University of Texas at San Antonio, One UTSA Circle, San Antonio, Texas 78249, USA.
Obrenovich
Mark E
ME
Reddy
V Prakash
VP
Shenk
Justin C
JC
Moreira
Paula I
PI
Nunomura
Akihiko
A
Zhu
Xiongwei
X
Smith
Mark A
MA
Perry
George
G
D000544:Alzheimer Disease / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D001921:Brain / Q000473:pathology; D016166:Free Radical Scavengers / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects
D000975:Antioxidants; D016166:Free Radical Scavengers