Effect of liver and kidney function on migafungin disposition in patients with hematologic malignancies.
The plasma concentration of micafungin (MCFG) after intravenous infusion of MCFG at 150 or 300 mg/day over 1 hour to 49 patients with hematologic malignancies were determined, and the relationship between the plasma concentrations and the patients' laboratory parameters of liver and kidney function was analyzed. Plasma samples were obtained at the end of the initial administration of MCFG, 5 to 6 hours after the start of the initial administration, immediately before the second dosing, immediately before the fourth dosing, and the end of the fourth dosing. The plasma concentration of MCFG was measured by high performance liquid chromatography. The plasma concentration of MCFG was correlated with the doses of MCFG per kilogram body weight. The peak concentration after the initial administration was 3.8 times higher than the trough level after the initial administration. The steady-state peak and trough levels were 1.4-1.5 times higher than those after the initial administration. There was no correlation between the laboratory parameters of liver/kidney function and the dose-normalized plasma concentration of MCFG. These results suggest that MCFG can be administered safely to patients with liver or kidney dysfunction without adjusting the dose.
Nakagawa
Yasunori
Y
Department of Hematology, Japanese Red Cross Medical Center, 4-1-22, Hiroo, Shibuya, Tokyo, 150-8935, Japan.
Ichii
Yoko
Y
Saeki
Yasuhiro
Y
Kodama
Masanobu
M
Kishino
Satoshi
S
Suzuki
Kenshi
K
D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000097:blood / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D054714:Echinocandins / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D019337:Hematologic Neoplasms / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007668:Kidney / Q000187:drug effects; D007677:Kidney Function Tests; D055666:Lipopeptides / Q000097:blood / Q000493:pharmacokinetics*; D008099:Liver / Q000187:drug effects; D008111:Liver Function Tests; D008297:Male; D000077551:Micafungin; D008875:Middle Aged; D009181:Mycoses / Q000150:complications / Q000517:prevention & control; D012709:Serum Albumin / Q000032:analysis
D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D012709:Serum Albumin; D000077551:Micafungin