title: Partners in imprinting: noncoding RNA and polycomb group proteins.
abstract: Establishment of genomic imprints during early development involves concerted epigenetic mechanisms. Two recent studies by Terranova et al. (in this issue of Developmental Cell) and Pandey et al. (in a recent issue of Molecular Cell) have demonstrated that Polycomb group proteins (PcG) and the Kcnq1ot1 regulatory RNA, respectively, are indispensable for gene- and lineage-specific chromatin modification and compaction of the paternally imprinted Kcnq1 cluster.
authors.affiliation: Department of Oncological Sciences, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA.
authors.forename: Hsan-Au
authors.initials: HA
authors.lastname: Wu
authors.forename: Emily
authors.initials: E
authors.lastname: Bernstein
mesh_terms: D000818:Animals; D005260:Female; D018507:Gene Expression Regulation, Developmental; D020868:Gene Silencing; D018392:Genomic Imprinting; D008297:Male; D051379:Mice; D008954:Models, Biological; D063146:Polycomb-Group Proteins; D022661:RNA, Untranslated / Q000378:metabolism*; D012097:Repressor Proteins / Q000378:metabolism*
chemical_list: D063146:Polycomb-Group Proteins; D022661:RNA, Untranslated; D012097:Repressor Proteins