title: A general approach to aza-heterocycles by means of domino sequences driven by hydroformylation.
abstract: The development of hydroformylative domino reactions of easily accessible vinyl acetamides is described. Extremely regioselective hydroformylation of terminal double bounds provides a transient N-acyliminium that can be trapped by various nucleophiles to give several aza-heterocylic scaffolds in a diastereoselective manner.
authors.affiliation: Faculté de Pharmacie, Université Louis Pasteur de Strasbourg, Laboratoire de Pharmacochimie de la Communication Cellulaire UMR 7175/LC1, 74, route du Rhin, BP 60024, 67401 Illkirch, France.
authors.forename: Etienne
authors.initials: E
authors.lastname: Airiau
authors.forename: Thomas
authors.initials: T
authors.lastname: Spangenberg
authors.forename: Nicolas
authors.initials: N
authors.lastname: Girard
authors.forename: Angèle
authors.initials: A
authors.lastname: Schoenfelder
authors.forename: Jessica
authors.initials: J
authors.lastname: Salvadori
authors.forename: Maurizio
authors.initials: M
authors.lastname: Taddei
authors.forename: André
authors.initials: A
authors.lastname: Mann
mesh_terms: D000081:Acetamides / Q000737:chemistry; D001372:Aza Compounds / Q000138:chemical synthesis*; D003500:Cyclization; D005561:Formates; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D007212:Indolizines / Q000138:chemical synthesis; D013237:Stereoisomerism
chemical_list: D000081:Acetamides; D001372:Aza Compounds; D005561:Formates; D006571:Heterocyclic Compounds; D007202:Indicators and Reagents; D007212:Indolizines; C030544:formic acid