title: Influence of coronary artery disease and coronary revascularization status on outcomes in patients with acute heart failure syndromes: a report from OPTIMIZE-HF (Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure).
abstract: BACKGROUND
  Coronary artery disease (CAD) is frequent among patients hospitalized with acute heart failure syndromes (AHFS).
  
  
  OBJECTIVE
  To describe the influence of coronary revascularization status on survival in patients with AHFS.
  
  
  RESULTS
  OPTIMIZE-HF enrolled 48,612 patients with AHFS from 259 U.S. hospitals. In-hospital data were obtained for all patients and post-discharge 60-90 day follow-up in a pre-specified 10% sample. CAD was associated with higher in-hospital (3.7% vs. 2.9%, OR 1.14, 95% CI 1.00-1.31) and post-discharge mortality (9.2% vs. 6.9%, HR 1.37, 95% CI 1.03-1.81) compared to no CAD. Post-discharge, patients with CAD who were not revascularized had higher mortality compared to patients without CAD (10.6% vs. 6.9%, HR 1.56, 95% CI 1.15-2.11). This association was similar in patients with left ventricular systolic dysfunction (EF <40%, adjusted HR 1.52, 95% CI 0.98-2.35) and preserved systolic function (EF > or =40%, adjusted HR1.58, 95% CI 1.05-2.39). Patients with CAD who were revascularized had similar mortality to patients without CAD (HR 1.06, 95% CI 0.62-1.80 for PSF, HR 1.13, 95% CI 0.71-1.80 for LVSD).
  
  
  CONCLUSIONS
  In AHFS, patients with CAD have a higher 60-90 day post-discharge mortality compared to no-CAD patients. However, patients with CAD who are revascularized appear to have similar post-discharge mortality when compared to the no-CAD group. This suggests that revascularization status may confer a survival advantage in this high risk population.
authors.affiliation: Northwestern University, Chicago, Illinois, United States.
authors.forename: Joseph S
authors.initials: JS
authors.lastname: Rossi
authors.forename: James D
authors.initials: JD
authors.lastname: Flaherty
authors.forename: Gregg C
authors.initials: GC
authors.lastname: Fonarow
authors.forename: Eduardo
authors.initials: E
authors.lastname: Nunez
authors.forename: Wendy
authors.initials: W
authors.lastname: Gattis Stough
authors.forename: William T
authors.initials: WT
authors.lastname: Abraham
authors.forename: Nancy M
authors.initials: NM
authors.lastname: Albert
authors.forename: Barry H
authors.initials: BH
authors.lastname: Greenberg
authors.forename: Christopher M
authors.initials: CM
authors.lastname: O'Connor
authors.forename: Clyde W
authors.initials: CW
authors.lastname: Yancy
authors.forename: James B
authors.initials: JB
authors.lastname: Young
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Davidson
authors.forename: Mihai
authors.initials: M
authors.lastname: Gheorghiade
mesh_terms: D000208:Acute Disease; D000368:Aged; D016001:Confidence Intervals; D003324:Coronary Artery Disease / Q000401:mortality / Q000503:physiopathology*; D005260:Female; D006333:Heart Failure / Q000401:mortality / Q000503:physiopathology*; D054144:Heart Failure, Diastolic / Q000503:physiopathology; D054143:Heart Failure, Systolic / Q000503:physiopathology; D006801:Humans; D008297:Male; D009204:Myocardial Revascularization; D016017:Odds Ratio; D011379:Prognosis; D016730:Program Development; D012189:Retrospective Studies; D012307:Risk Factors; D013577:Syndrome; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left