Preparation and characterization of bioactive mesoporous wollastonite - Polycaprolactone composite scaffold.
A well-defined mesoporous structure of wollastonite with high specific surface area was synthesized using surfactant P123 (triblock copolymer) as template, and its composite scaffolds with poly(epsilon-caprolactone) (PCL) were fabricated by a simple method of solvent casting-particulate leaching. The measurements of the water contact angles suggest that the incorporation of either mesoporous wollastonite (m-WS) or conventional wollastonite (c-WS) into PCL could improve the hydrophilicity of the composites, and the former was more effective than the later. The bioactivity of the composite scaffold was evaluated by soaking the scaffolds in a simulated body fluid (SBF) and the results show that the m-WS/PCL composite (m-WPC) scaffolds can induce a dense and continuous layer of apatite after soaking for 1 week, as compared with the scattered and discrete apatite particles on the c-WS/PCL composite (c-WPC) scaffolds. The m-WPC had a significantly enhanced apatite-forming bioactivity compared with the c-WPC owing to the high specific surface area and pore volume of m-WS. In addition, attachment and proliferation of MG(63) cells on m-WPC scaffolds were significantly higher than that of c-WPC, revealing that m-WPC scaffolds had excellent biocompatibility. Such improved properties of m-WPC should be helpful for developing new biomaterials and may have potential use in hard tissue repair.
Wei
Jie
J
Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, PR China.
Chen
Fangping
F
Shin
Jung-Woog
JW
Hong
Hua
H
Dai
Chenglong
C
Su
Jiancan
J
Liu
Changsheng
C
D001031:Apatites / Q000737:chemistry; D001826:Body Fluids; D017610:Calcium Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D002448:Cell Adhesion; D002460:Cell Line; D049109:Cell Proliferation; D006801:Humans; D007477:Ions; D008422:Materials Testing; D019563:Mechanics; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry*; D016062:Porosity; D011208:Powders; D017640:Silicates / Q000138:chemical synthesis* / Q000737:chemistry*; D012996:Solutions; D013696:Temperature; D054457:Tissue Scaffolds; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
D001031:Apatites; D017610:Calcium Compounds; D007477:Ions; D011091:Polyesters; D011208:Powders; D017640:Silicates; D012996:Solutions; D014867:Water; C016240:polycaprolactone; C031293:calcium silicate