Induced pluripotency of mouse and human somatic cells.
The identification of transcription factors to induce pluripotency directly in somatic cells has given researchers a unique platform on which to dissect the mechanisms underlying epigenetic reprogramming. In addition, induced pluripotent stem (iPS) cells have enabled the derivation of patient-specific cells for the study and potential treatment of a variety of diseases. Here, we discuss recent discoveries in the reprogramming field including work from our own laboratory.
Maherali
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Massachusetts General Hospital Cancer Center and Center for Regenerative Medicine, Harvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Boston, Massachusetts 02114, USA
Hochedlinger
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D000818:Animals; D002454:Cell Differentiation / Q000235:genetics* / Q000502:physiology*; D044127:Epigenesis, Genetic; D006801:Humans; D051379:Mice; D008954:Models, Biological; D016254:Mutagenesis, Insertional; D039904:Pluripotent Stem Cells / Q000166:cytology* / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology
D014157:Transcription Factors