Presence of interstereocilial links in waltzer mutants suggests Cdh23 is not essential for tip link formation.
Cadherin23 has been proposed to form the upper part of the tip link, an interstereocilial link believed to control opening of transducer channels of sensory hair cells. However, we detect tip link-like links in mouse mutants with null alleles of Cdh23, suggesting the presence of other components that permit formation of a link between the tip of one stereocilium and the side of the adjacent taller stereocilium.
Rzadzinska
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AK
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, United Kingdom.
Steel
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D000818:Animals; D000831:Animals, Newborn; D015820:Cadherins / Q000235:genetics / Q000502:physiology*; D002923:Cilia / Q000648:ultrastructure; D006199:Hair Cells, Auditory, Inner / Q000502:physiology / Q000648:ultrastructure; D051379:Mice; D008817:Mice, Mutant Strains; D008855:Microscopy, Electron, Scanning / Q000379:methods; D009154:Mutation
D015820:Cadherins; C499091:Cdh23 protein, mouse