Transplanted dopaminergic neurons develop PD pathologic changes: a second case report.
This report describes pathological changes within the grafted neurons of another patient with Parkinson's disease (PD) who died 14 years posttransplantation. Although numerous healthy appearing grafted neurons were present at this long-term time point, some displayed Lewy bodies as evidenced by alpha-synuclein, ubiquitin, and thioflavin-S staining. Additionally, there was a general loss of dopamine transporter-immunoreactivity in grafted neurons. Some grafted cell displayed a loss of tyrosine hydroxylase. These data support the emerging concept that PD-like pathology is seen in young grafted neurons when they survive long term.
Kordower
Jeffrey H
JH
Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA. jkordowe@rush.edu
Chu
Yaping
Y
Hauser
Robert A
RA
Olanow
C Warren
CW
Freeman
Thomas B
TB
D000328:Adult; D001921:Brain / Q000473:pathology*; D017690:Cell Transplantation / Q000502:physiology*; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D008297:Male; D009474:Neurons / Q000378:metabolism*; D010300:Parkinson Disease / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism; D050493:Vesicular Monoamine Transport Proteins / Q000378:metabolism
C493452:SLC18A2 protein, human; D050493:Vesicular Monoamine Transport Proteins; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine