Ultralow fouling zwitterionic polymers grafted from surfaces covered with an initiator via an adhesive mussel mimetic linkage.
In this work, nonfouling zwitterionic polymers were grafted via surface-initiated atom transfer radical polymerization (ATRP) from surfaces covered with an adhesive catechol initiator. The catechol initiator was attached to both bare gold and amino-functionalized surfaces, and the nonfouling performances of the resulting polymer brushes were compared. Under optimal conditions, ultralow protein adsorption from both single-protein solutions of fibrinogen and lysozyme and complex media of 10% blood serum and 100% blood plasma/serum was achieved. Furthermore, the 3-day accumulation of Pseudomonas aeruginosa on the treated glass surfaces was studied in situ using a laminar flow chamber. The results showed that these zwitterionic coatings dramatically reduced the biofilm formation of P. aeruginosa as compared to the reference bare glass.
Li
Guozhu
G
Department of Chemical Engineering, University of Washington, Seattle, Washington 98195, USA.
Xue
Hong
H
Cheng
Gang
G
Chen
Shengfu
S
Zhang
Fengbao
F
Jiang
Shaoyi
S
D000327:Adsorption; D000818:Animals; D001422:Bacterial Adhesion / Q000187:drug effects; D018441:Biofilms / Q000187:drug effects; D032701:Biomimetics; D049872:Bivalvia / Q000737:chemistry*; D002396:Catechols / Q000737:chemistry; D005340:Fibrinogen / Q000737:chemistry; D005898:Glass; D006046:Gold; D007202:Indicators and Reagents; D008856:Microscopy, Fluorescence; D009113:Muramidase / Q000097:blood / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013499:Surface Properties
D002396:Catechols; D007202:Indicators and Reagents; D011108:Polymers; D006046:Gold; D005340:Fibrinogen; D009113:Muramidase