Ethnic differences in HLA antigens in Chilean donors and recipients: data from the National Renal Transplantation Program.
To describe HLA antigen distribution, looking for possible markers of renal disease in Mapuche and non-Mapuche people in the renal transplantation program, we reviewed data from 1297 histocompatibility studies of the Chilean national renal transplantation program (421 donors and 876 recipients), performed between 2000 and 2005. Mapuche people were classified according to their family surnames. The most frequent antigens found among the total Chilean population were A2 (48%), A19 (33%), B16 (33%), B35 (26%), DR4 (38%), and DR6 (28%), without significant differences between donors and recipients. Among the 114 individuals (9%) classified as Mapuche, the most frequent antigens were A28 (49%), A2 (44%), B16 (63%), B35 (24%), DR4 (48%), and DR8 (30%), with A28/B16/DR4 as the most common haplotype. In contrast, A28, B16, DR4, and DR8 were significantly more frequent in Mapuche compared with non-Mapuche people. B8 was significantly more frequent in Mapuche recipients than in non-Mapuche recipients and Mapuche donors. The higher frequency of some HLA antigens in Mapuche people was confirmed, possibly corresponding to ethnic markers. The special concentration of B8 among Mapuche recipients might represent a genetic factor predisposing to chronic renal disease in this human group.
Droguett
M A
MA
Laboratorio de Histocompatibilidad, Unidad de Nefrología, Facultad de Medicina UACH, Hospital Regional, Valdivia, Chile.
Beltran
R
R
Ardiles
R
R
Raddatz
N
N
Labraña
C
C
Arenas
A
A
Flores
J
J
Alruiz
P
P
Mezzano
S
S
Ardiles
L
L
D002677:Chile; D005006:Ethnicity / Q000235:genetics; D006680:HLA Antigens / Q000235:genetics* / Q000276:immunology*; D015234:HLA-A Antigens / Q000235:genetics / Q000276:immunology; D015235:HLA-B Antigens / Q000235:genetics / Q000276:immunology; D006684:HLA-DR Antigens / Q000235:genetics / Q000276:immunology; D006650:Histocompatibility Testing / Q000379:methods; D006801:Humans; D007676:Kidney Failure, Chronic / Q000235:genetics / Q000276:immunology; D016030:Kidney Transplantation / Q000276:immunology*; D016133:Polymerase Chain Reaction
D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens