3D jigsaw puzzle in rotavirus assembly.
In this issue of Structure, Lu et al. (2008) report results of structural and functional analysis of rotavirus RNA-dependent RNA polymerase, VP1. Based on their analyses of VP1 in RNA free and bound forms, the authors propose a mechanism for coordinated genome packaging and replication.
Shatkin
Aaron
A
Center for Advanced Biotechnology and Medicine, Rutgers University, 679 Hoes Lane, Piscataway, NJ 08854, USA.
Das
Kalyan
K
Arnold
Eddy
E
D012321:DNA-Directed RNA Polymerases / Q000737:chemistry*; D008958:Models, Molecular; D012367:RNA, Viral / Q000737:chemistry; D012401:Rotavirus / Q000201:enzymology / Q000235:genetics*
D012367:RNA, Viral; D012321:DNA-Directed RNA Polymerases