title: Tagging SNP association study of the IL-1beta gene (IL1B) and childhood-onset mood disorders.
abstract: Given substantial evidence for IL-1beta involvement in the etiology of depression, the IL1B gene is a strong candidate for involvement in susceptibility to depressive disorders. However, association studies investigating this, to date, have been limited to just two polymorphisms (rs1143627[-31T/C] and rs16944[-511C/T]) that constitute only a fraction of the genetic variation that is actually present across this gene in the population. Here, in a family-based association study of childhood-onset mood disorders (COMD), characterized by onset of depression before the age of 15, we have used a gene-wide approach, employing a panel of five tagging SNPs spanning the entire gene. Based on TDT analyses of both individual alleles and haplotypes, in a study sample of 646 families (with 782 affected children), none of the SNPs, including those implicated in transcriptional regulation of the gene, showed evidence for association with COMD. This is the largest and most comprehensive study of IL1B in relation to mood disorders that has been carried out, to date. The results do not support the involvement of IL1B as a major factor in genetic risk for early-onset mood disorders.
authors.affiliation: Toronto Western Research Institute, University Health Network, Ontario, Canada.
authors.forename: Virginia L
authors.initials: VL
authors.lastname: Misener
authors.forename: Lissette
authors.initials: L
authors.lastname: Gomez
authors.forename: Karen G
authors.initials: KG
authors.lastname: Wigg
authors.forename: Nicole
authors.initials: N
authors.lastname: King
authors.forename: Enikõ
authors.initials: E
authors.lastname: Kiss
authors.forename: Gabriella
authors.initials: G
authors.lastname: Daróczi
authors.forename: Krisztina
authors.initials: K
authors.lastname: Kapornai
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Tamás
authors.forename: László
authors.initials: L
authors.lastname: Mayer
authors.forename: Júlia
authors.initials: J
authors.lastname: Gádoros
authors.forename: Ildikó
authors.initials: I
authors.lastname: Baji
authors.forename: James L
authors.initials: JL
authors.lastname: Kennedy
authors.forename: Maria
authors.initials: M
authors.lastname: Kovacs
authors.forename: Agnes
authors.initials: A
authors.lastname: Vetró
authors.forename: Cathy L
authors.initials: CL
authors.lastname: Barr
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D002648:Child; D002874:Chromosome Mapping; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D015810:Linkage Disequilibrium; D008297:Male; D019964:Mood Disorders / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D035781:Siblings
chemical_list: C508585:IL1B protein, human; D053583:Interleukin-1beta