Meta- and pooled analyses of the effect of glutathione S-transferase M1 and T1 deficiency on chronic obstructive pulmonary disease.
BACKGROUND
Chronic obstructive pulmonary disease (COPD) is a complex polygenic disease in which gene-environment interactions are very important. A number of studies have investigated the genotypes of glutathione S-transferase M1 and T1 (GSTM1 and GSTT1) in relation to COPD susceptibility in different populations. However, the results of individual studies have been inconsistent.


METHODS
To address the inconsistent findings in studies of the association of the polymorphism of the GSTM1 and GSTT1 genes with susceptibility to COPD, we performed a meta-analysis of the published data. We searched the Medline database for case-control studies published from 1966 to July 2008. Data were extracted and pooled, and ORs were calculated with their 95%CIs.


RESULTS
Twelve eligible studies comprising 1697 patients with COPD and 1867 controls were included in the meta-analysis. The pooled result showed that the GSTM1 deficiency was associated with risk of COPD (OR 1.46, 95%CI 1.16-1.83). Subgroup analysis supported the results in smoking and non-Asian populations, but not in Asian populations. The GSTT1 deficiency was not associated with risk of COPD.


CONCLUSIONS
The GSTM1 gene is a genetic contributor to overall COPD susceptibility in non-Asian populations, and the GSTT1 gene is not associated with COPD.
Hu
G
G
Guangzhou Institute of Respiratory Diseases, State Key Laboratory of Respiratory Diseases, First Affiliated Hospital, Guangzhou Medical College, Guangzhou, Guangdong, China.
Yao
W
W
Zhou
Y
Y
Hu
J
J
Shi
Z
Z
Li
B
B
Ran
P
P
D004198:Disease Susceptibility; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005982:Glutathione Transferase / Q000172:deficiency* / Q000235:genetics; D006801:Humans; D011110:Polymorphism, Genetic; D029424:Pulmonary Disease, Chronic Obstructive / Q000201:enzymology*
D005982:Glutathione Transferase; C413545:glutathione S-transferase T1