title: [A case of interstitial pneumonia after S-1 administration for gastric cancer].
abstract: An 80-year-old man with no history of thoracic radiotherapy nor interstitial pneumonia was administered S-1 for gastric cancer in June 2007. Twenty-two days after starting S-1, he had dyspnea, and X-rays showed reticular shadows in both lung fields, yielding a diagnosis of interstitial pneumonia. Drug lymphocyte stimulating test (DLST) was positive against S-1. The total dose of S-1 was 2,200 mg to the symptom onset. We immediately started steroid pulse therapy after emergency hospitalization, and it revealed improved condition and he was able to leave the hospital. S-1 administration is becoming frequent because RCTs supported the efficacy of S-1 for gastric cancer. Interstitial pneumonia as a side effect of S-1 is not frequent, but it is necessary to pay attention to dyspnea throughout the duration of administration.
authors.affiliation: Gastroenterological Center, Yokohama City University Medical Center.
authors.forename: Naoto
authors.initials: N
authors.lastname: Yamamoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Ohshima
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Sato
authors.forename: Hirochika
authors.initials: H
authors.lastname: Makino
authors.forename: Amane
authors.initials: A
authors.lastname: Kanazawa
authors.forename: Takanobu
authors.initials: T
authors.lastname: Yamada
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Murakami
authors.forename: Norio
authors.initials: N
authors.lastname: Yukawa
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Nagano
authors.forename: Shoichi
authors.initials: S
authors.lastname: Fujii
authors.forename: Chikara
authors.initials: C
authors.lastname: Kunisaki
authors.forename: Toshinori
authors.initials: T
authors.lastname: Tsukahara
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Rino
authors.forename: Munetaka
authors.initials: M
authors.lastname: Masuda
authors.forename: Toshio
authors.initials: T
authors.lastname: Imada
mesh_terms: D000369:Aged, 80 and over; D004338:Drug Combinations; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000150:complications* / Q000000981:diagnostic imaging*; D008297:Male; D010094:Oxonic Acid / Q000008:administration & dosage* / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D005641:Tegafur / Q000008:administration & dosage* / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid