title: Atrial fibrillation organization: quantification of propofol effects.
abstract: The effect of conventional i.v. anaesthetic agents on atrial fibrillation (AF) dynamics has not been fully addressed. We aim to evaluate whether the most frequently used intravenous anaesthetic agent, propofol, modifies AF organization parameters. Multiple and simultaneous intraatrial bipolar recordings from 27 patients in AF were analyzed before and after infusing a propofol bolus. Signal organization parameters were determined using time and frequency domain analysis. Non-linear analysis was also performed to determine signal entropy. Linear analysis showed that AF becomes more organized in right atrial recordings after infusing propofol, increasing interelectrode correlation (difference of 0.017 +/- 0.005), with the contrary effect on the left atrial dipoles (difference of -0.015 +/- 0.009, p = 0.008). Entropy analysis showed similar findings, achieving a statistical significance of p = 0.001 with Shannon Entropy.
authors.affiliation: Escuela Universitaria Politécnica, Campus Universitario, Innovation in Bioengineering Research Group (IBIG), DIEEAC, UCLM, Camino del Pozuelo sn, 16071 Cuenca, Spain. raquel.cervigon@uclm.es
authors.forename: Raquel
authors.initials: R
authors.lastname: Cervigón
authors.forename: Javier
authors.initials: J
authors.lastname: Moreno
authors.forename: César
authors.initials: C
authors.lastname: Sánchez
authors.forename: Richard B
authors.initials: RB
authors.lastname: Reilly
authors.forename: Julián
authors.initials: J
authors.lastname: Villacastín
authors.forename: José
authors.initials: J
authors.lastname: Millet
authors.forename: Francisco
authors.initials: F
authors.lastname: Castells
mesh_terms: D000328:Adult; D000368:Aged; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D001281:Atrial Fibrillation / Q000503:physiopathology*; D004562:Electrocardiography / Q000379:methods; D019277:Entropy; D005260:Female; D006325:Heart Atria / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D015742:Propofol / Q000494:pharmacology*; D012815:Signal Processing, Computer-Assisted
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol