title: Four new biflavonoids from Selaginella uncinata and their anti-anoxic effect.
abstract: The 60% ethanolic extract of Selaginella uncinata (Desv.) Spring possessed potent anti-anoxic effect in the anoxic PC12 cell assay. A phytochemical study of its EtOAc-soluble part led to the isolation of four new and three known biflavonoids. Their structures were established on the basis of physico-chemical properties and spectroscopic analysis. The absolute configurations of the new compounds were determined with the aid of circular dichroism (CD) spectroscopy. Compounds 4 and 5 showed potent anti-anoxic effect in the anoxic PC12 cell assay.
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
authors.forename: Jun-Xia
authors.initials: JX
authors.lastname: Zheng
authors.forename: Nai-Li
authors.initials: NL
authors.lastname: Wang
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Liu
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Chen
authors.forename: Ming-Ming
authors.initials: MM
authors.lastname: Li
authors.forename: Li-Ying
authors.initials: LY
authors.lastname: Wu
authors.forename: Ming
authors.initials: M
authors.lastname: Fan
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Yao
mesh_terms: D000818:Animals; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology*; D000860:Hypoxia / Q000188:drug therapy; D015394:Molecular Structure; D010101:Oxygen Consumption / Q000187:drug effects; D016716:PC12 Cells; D051381:Rats; D032503:Selaginellaceae / Q000737:chemistry*
chemical_list: D005419:Flavonoids