title: Short communication: Long-term persistence of vaccine-induced HIV seropositivity among healthy volunteers.
abstract: Long-term persistence of HIV vaccine-induced seropositivity in uninfected HIV vaccine recipients remains unknown. The duration of HIV humoral-induced responses was assessed in 72 volunteers who had received rgp160 and/or HIV recombinant canarypox virus constructs able to induce immune responses detectable using standard serological tests. Among the 43 rgp160 recipients, 94% and 83% remained HIV seropositive after 5 and 8 years of follow-up, respectively, while all the 29 volunteers who had received canarypox constructs alone were seronegative after 5 years. Because rgp160 induces long-term persistence (>8 years) of vaccine-induced HIV seropositivity, volunteers should be offered long-term follow-up to monitor their serological evolution.
authors.affiliation: AP-HP, Groupe Hospitalier Cochin-Saint-Vincent de Paul, CIC de Vaccinologie Cochin-Pasteur, Pôle de Médecine, Paris, France.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Silbermann
authors.forename: Michel
authors.initials: M
authors.lastname: Tod
authors.forename: Corinne
authors.initials: C
authors.lastname: Desaint
authors.forename: Gilles
authors.initials: G
authors.lastname: Pialoux
authors.forename: Karine
authors.initials: K
authors.lastname: Petitprez
authors.forename: Laurence
authors.initials: L
authors.lastname: Slama
authors.forename: Hubert
authors.initials: H
authors.lastname: Poncelet
authors.forename: Corinne
authors.initials: C
authors.lastname: Moreau
authors.forename: Veronique
authors.initials: V
authors.lastname: Mazarin
authors.forename: Farad
authors.initials: F
authors.lastname: Heshmati
authors.forename: Dominique
authors.initials: D
authors.lastname: Salmon-Ceron
authors.forename: Jean-Gerard
authors.initials: JG
authors.lastname: Guillet
authors.forename: Odile
authors.initials: O
authors.lastname: Launay
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology*; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D015483:HIV Antibodies / Q000097:blood*; D006679:HIV Seropositivity / Q000276:immunology; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014614:Vaccines, Synthetic / Q000276:immunology
chemical_list: D016915:AIDS Vaccines; D015483:HIV Antibodies; D014614:Vaccines, Synthetic