title: Helicobacter pylori virulence and the diversity of gastric cancer in Asia.
abstract: Infection with cagPAI positive strains of Helicobacter pylori is recognized as being associated with an increased risk of gastric cancer. This article reviews the current knowledge on the structures and pathological functions of cagPAI and the CagA protein, focusing especially on the molecular mechanism through which CagA may be involved in gastric carcinogenesis. The possible link between the geographical distribution of cagPAI and cagA variations and gastric cancer diversity in Asia is also discussed.
authors.affiliation: Department of Gastroenterology, Faculty of Medicine, Oita University, Oita 879-5593, Japan.|Department of Molecular Pathology, Faculty of Medicine, Oita University, Oita 879-5593, Japan.
authors.forename: Lam Tung
authors.initials: LT
authors.lastname: Nguyen
authors.affiliation: Department of Human Environmental and Social Medicine, Faculty of Medicine, Oita University, Oita 879-5593, Japan.|Department of Molecular Pathology, Faculty of Medicine, Oita University, Oita 879-5593, Japan.
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Uchida
authors.affiliation: Department of Gastroenterology, Faculty of Medicine, Oita University, Oita 879-5593, Japan.
authors.forename: Kazunari
authors.initials: K
authors.lastname: Murakami
authors.affiliation: Department of Gastroenterology, Faculty of Medicine, Oita University, Oita 879-5593, Japan.
authors.forename: Toshio
authors.initials: T
authors.lastname: Fujioka
authors.affiliation: Department of Molecular Pathology, Faculty of Medicine, Oita University, Oita 879-5593, Japan.
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Moriyama
mesh_terms: D000942:Antigens, Bacterial / Q000235:genetics; D001208:Asia / Q000453:epidemiology; D001426:Bacterial Proteins / Q000235:genetics; D005260:Female; D044404:Genomic Islands / Q000235:genetics; D016481:Helicobacter Infections / Q000150:complications* / Q000453:epidemiology* / Q000382:microbiology; D016480:Helicobacter pylori / Q000235:genetics / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000382:microbiology / Q000473:pathology; D014774:Virulence
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C080866:cagA protein, Helicobacter pylori