title: Association between interleukin 1 polymorphisms and rheumatoid arthritis susceptibility: a metaanalysis.
abstract: OBJECTIVE
  To determine whether interleukin 1 (IL-1) polymorphisms confer susceptibility to rheumatoid arthritis (RA).
  
  
  METHODS
  We conducted metaanalyses on associations between IL-1 polymorphisms and RA susceptibility, using fixed or random effects models.
  
  
  RESULTS
  A total of 18 separate comparisons were made using 10 European, 7 Asian, and 1 Latin American population samples. Metaanalysis of the IL-1B+3954 CC genotype revealed an association with RA in all subjects (odds ratio=0.776, 95% confidence interval=0.609-0.988, p=0.040). In Asians, an association between IL-1B+3954 and RA was identified. In contrast, no association was found between the IL-1B+3954 polymorphism and RA susceptibility in European populations. Metaanalyses of the IL-1B-511 and IL-1RN VNTR polymorphisms identified no association between these polymorphisms and RA.
  
  
  CONCLUSIONS
  Our metaanalysis shows that the IL-1B+3954 polymorphism was associated with the development of RA, but only in Asians.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1 ga, Anam-dong, Seongbuk-gu, Seoul, 136-705, Korea. lyhcgh@korea.ac.kr
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Lee
authors.forename: Jong Dae
authors.initials: JD
authors.lastname: Ji
authors.forename: Gwan Gyu
authors.initials: GG
authors.lastname: Song
mesh_terms: D001172:Arthritis, Rheumatoid / Q000208:ethnology* / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000208:ethnology; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D007375:Interleukin-1