Ronin and caspases in embryonic stem cells: a new perspective on regulation of the pluripotent state.
Described here are recent discoveries in my laboratory which suggest that the complement of factors needed to direct ES cell pluripotency may be considerably larger than originally thought and may include proteins that act independently of the canonical factors described thus far. They also provide insight into a novel screening method that could be used to accelerate the identification and characterization of such factors.
Zwaka
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Baylor College of Medicine, Houston, Texas 77030, USA.
D000818:Animals; D020169:Caspases / Q000502:physiology*; D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D039904:Pluripotent Stem Cells / Q000166:cytology* / Q000502:physiology*; D011247:Pregnancy; D012097:Repressor Proteins
D004268:DNA-Binding Proteins; D012097:Repressor Proteins; C530078:Thap11 protein, mouse; D020169:Caspases