title: Concordant colon tumors in monozygotic twins previously treated for prostate cancer.
abstract: This report describes the quasi-simultaneous occurrence of colon cancers in monozygotic twin brothers (age 63 years) who had undergone androgen deprivation therapy for prostate cancers 4 years earlier. Concordance among male twins for both of these cancers has never been reported. Although the family history suggested possible genetic predispositions to both cancers, the twins have no evidence of the genetic alterations associated with hereditary colorectal tumors. We explore the possibility that colorectal tumorigenesis in these twins was fuelled by a combination of genetic and iatrogenic factors, in particular the androgen deprivation therapy used to treat their prostate cancers.
authors.affiliation: Department of Medical Oncology, Kantonsspital, St Gallen, Switzerland.
authors.forename: Arnoud
authors.initials: A
authors.lastname: Templeton
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Marra
authors.forename: Emanuele
authors.initials: E
authors.lastname: Valtorta
authors.forename: Karl
authors.initials: K
authors.lastname: Heinimann
authors.forename: Hansjakob
authors.initials: H
authors.lastname: Müller
authors.forename: Dieter
authors.initials: D
authors.lastname: Köberle
authors.forename: Silke
authors.initials: S
authors.lastname: Gillessen
mesh_terms: D002648:Child; D003110:Colonic Neoplasms / Q000150:complications / Q000235:genetics*; D005817:Genetic Counseling / Q000523:psychology; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000150:complications / Q000235:genetics*; D014430:Twins, Monozygotic / Q000235:genetics*