p120-Ras GTPase activating protein (RasGAP): a multi-interacting protein in downstream signaling.
p120-RasGAP (Ras GTPase activating protein) plays a key role in the regulation of Ras-GTP bound by promoting GTP hydrolysis via its C-terminal catalytic domain. The p120-RasGAP N-terminal part contains two SH2, SH3, PH (pleckstrin homology) and CaLB/C2 (calcium-dependent phospholipid-binding domain) domains. These protein domains allow various functions, such as anti-/pro-apoptosis, proliferation and also cell migration depending of their distinct partners. The p120-RasGAP domain participates in protein-protein interactions with Akt, Aurora or RhoGAP to regulate functions described bellow. Here, we summarize, in angiogenesis and cancer, the various functional roles played by p120-RasGAP domains and their effector partners in downstream signaling.
Pamonsinlapatham
Perayot
P
Université Paris Descartes, UFR Biomédicale, Laboratoire de Pharmacochimie Moléculaire et Cellulaire, 45 Rue des Saints-Pères, 75270 Paris Cedex 06, France.
Hadj-Slimane
Réda
R
Lepelletier
Yves
Y
Allain
Barbara
B
Toccafondi
Mirco
M
Garbay
Christiane
C
Raynaud
Françoise
F
D000818:Animals; D020134:Catalytic Domain; D011905:Genes, ras; D006801:Humans; D008954:Models, Biological; D017434:Protein Structure, Tertiary; D015398:Signal Transduction / Q000235:genetics; D020729:p120 GTPase Activating Protein / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D020703:ras GTPase-Activating Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D018631:ras Proteins / Q000235:genetics / Q000378:metabolism*; D018909:src Homology Domains
D020729:p120 GTPase Activating Protein; D020703:ras GTPase-Activating Proteins; D018631:ras Proteins