title: Stress-related factors in cannabis use and misuse: implications for prevention and treatment.
abstract: We examined the role of stress as a risk factor and motivation for cannabis use/misuse. A systematic review of studies gathered from PsychINFO and MEDLINE databases was conducted. Findings suggest that cannabis is commonly used as a stress-coping strategy. Negative life events, trauma, and maladaptive coping were all related to consumption. Cannabis use for stress-coping purposes was most evident when examining chronic as compared with experimental use. Although many individuals may be able to use cannabis without consequences, there appears to be a subset of individuals who experience greater life stress and who may be more likely to use for stress-coping purposes. These individuals may be at greatest risk for addiction. Chronic use may potentiate stress-related motivation to use/abuse cannabis and is associated with decision-making deficits and alterations in brain-stress pathways that may exacerbate compulsive drug seeking and sensitize individuals to stress-related drug use. Overall, stress-coping interventions and harm reduction focused on reducing the amount ingested may facilitate prevention and recovery efforts.
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, Substance Abuse Treatment Unit, 1 Long Wharf Drive, Box 18, New Haven, CT 06511, USA. scott.hyman@yale.edu
authors.forename: Scott M
authors.initials: SM
authors.lastname: Hyman
authors.forename: Rajita
authors.initials: R
authors.lastname: Sinha
mesh_terms: D000223:Adaptation, Psychological; D016739:Behavior, Addictive / Q000209:etiology; D016208:Databases, Factual; D003657:Decision Making; D040261:Harm Reduction; D006801:Humans; D002189:Marijuana Abuse / Q000517:prevention & control / Q000523:psychology* / Q000628:therapy; D012307:Risk Factors; D013315:Stress, Psychological / Q000150:complications*