title: Pathological examination with two-millimetre serial sectioning for sentinel lymph node biopsies in breast cancer.
abstract: OBJECTIVE
  To compare enhanced pathology with serial sectioning and the transcription-reverse transcription concerted reaction (TRC) for detecting sentinel node (SN) metastasis in breast cancer cases.
  
  
  METHODS
  In total, 115 SN samples from 32 breast cancer cases were investigated by pathological examination with 2.0-mm serial sectioning and by quantitative analysis of carcinoembryonic antigen messenger RNA with the TRC.
  
  
  RESULTS
  The results were concordant in 98.3% of these cases. Two histologically metastatic nodes tested negative by TRC, whereas none tested positive by TRC alone.
  
  
  CONCLUSIONS
  Pathological examination with 2-mm sectioning showed superior performance to TRC under the study conditions.
authors.affiliation: Department of General Surgery, Yokohama City University Medical Center, Yokohama, Japan. tishik@urahp.yokohama-cu.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Ishikawa
authors.forename: T
authors.initials: T
authors.lastname: Sasaki
authors.forename: E
authors.initials: E
authors.lastname: Miyajima
authors.forename: D
authors.initials: D
authors.lastname: Shimizu
authors.forename: A
authors.initials: A
authors.lastname: Nozawa
authors.forename: K
authors.initials: K
authors.lastname: Kawachi
authors.forename: A
authors.initials: A
authors.lastname: Takase
authors.forename: N
authors.initials: N
authors.lastname: Miyazaki
authors.forename: R
authors.initials: R
authors.lastname: Tomioka
authors.forename: M
authors.initials: M
authors.lastname: Kikuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Amari
authors.forename: Y
authors.initials: Y
authors.lastname: Fukuno
authors.forename: H
authors.initials: H
authors.lastname: Takeda
authors.forename: T
authors.initials: T
authors.lastname: Hayashi
authors.forename: S
authors.initials: S
authors.lastname: Onaka
authors.forename: Y
authors.initials: Y
authors.lastname: Ichikawa
authors.forename: H
authors.initials: H
authors.lastname: Shimada
mesh_terms: D001943:Breast Neoplasms / Q000737:chemistry / Q000473:pathology*; D002272:Carcinoembryonic Antigen / Q000032:analysis; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000737:chemistry / Q000473:pathology*; D021701:Sentinel Lymph Node Biopsy / Q000379:methods*
chemical_list: D002272:Carcinoembryonic Antigen