title: Synthetic studies on kohamaic acids: synthesis of structurally simplified analogs of kohamaic acid A.
abstract: Kohamaic acid A is a potent DNA polymerase inhibitor isolated from the Okinawan marine sponge Ircinia sp. A series of structurally simplified analogs of kohamaic acid A were synthesized with the aim of evaluating structure-activity relationships.
authors.affiliation: Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, Japan.
authors.forename: Hirosato
authors.initials: H
authors.lastname: Takikawa
authors.forename: Naoki
authors.initials: N
authors.lastname: Kamatani
authors.forename: Kohei
authors.initials: K
authors.lastname: Nakanishi
authors.forename: Takuya
authors.initials: T
authors.lastname: Tashiro
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Sasaki
authors.forename: Hiromi
authors.initials: H
authors.lastname: Yoshida
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Mizushina
mesh_terms: D000818:Animals; D002417:Cattle; D004256:DNA Polymerase I / Q000037:antagonists & inhibitors; D019951:DNA Polymerase beta / Q000037:antagonists & inhibitors; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D013729:Terpenes; C475030:kohamaic acid A; D004256:DNA Polymerase I; D019951:DNA Polymerase beta