title: Paraneoplastic gastro-intestinal anti-Hu syndrome in neuroblastoma.
abstract: The anti-Hu syndrome is a well-known paraneoplastic syndrome and may be rarely seen in patients with neuroblastoma. However, it is relatively unknown that anti-Hu antibodies can cause gastro-intestinal signs and symptoms. We report on a child with neuroblastoma who presented with gastro-intestinal disturbances as a result of the anti-Hu syndrome and summaries two similar case reports reported in literature. Neuroblastoma patients with gastro-intestinal disturbances, ranging from constipation to a paralytic ileus, might suffer from the gastro-intestinal anti-Hu syndrome. The causative antibodies can be determined to diagnose or exclude this syndrome, and successful treatment is possible.
authors.affiliation: Department of Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: C A M
authors.initials: CA
authors.lastname: Drukker
authors.forename: H A
authors.initials: HA
authors.lastname: Heij
authors.forename: L C D
authors.initials: LC
authors.lastname: Wijnaendts
authors.forename: J I M L
authors.initials: JI
authors.lastname: Verbeke
authors.forename: G J L
authors.initials: GJ
authors.lastname: Kaspers
mesh_terms: D001323:Autoantibodies / Q000032:analysis / Q000276:immunology*; D002675:Child, Preschool; D051959:ELAV Proteins / Q000276:immunology*; D005767:Gastrointestinal Diseases / Q000150:complications* / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D008297:Male; D009447:Neuroblastoma / Q000150:complications* / Q000175:diagnosis; D010257:Paraneoplastic Syndromes / Q000150:complications* / Q000175:diagnosis* / Q000276:immunology
chemical_list: D001323:Autoantibodies; D051959:ELAV Proteins