Development of a method for the parallel synthesis and purification of N-substituted pantothenamides, known inhibitors of coenzyme A biosynthesis and utilization.
N-Substituted pantothenamides are a class of pantothenic acid analogues which have been shown to act as inhibitors of coenzyme A biosynthesis and utilization, especially by blocking fatty acid metabolism through formation of inactive acyl carrier proteins. To fully explore the chemical diversity and inhibitory potential of these analogues we have developed a simple method for the parallel synthesis and purification of any number of pantothenamides from a single precursor, and subsequently evaluated a small library of these compounds as inhibitors of bacterial growth to demonstrate the potential and utility of the method.
van Wyk
Marianne
M
Department of Biochemistry, Stellenbosch University, Matieland 7602, South Africa.
Strauss
Erick
E
D000588:Amines / Q000737:chemistry; D049109:Cell Proliferation / Q000187:drug effects; D003065:Coenzyme A / Q000037:antagonists & inhibitors* / Q000096:biosynthesis / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004926:Escherichia coli / Q000166:cytology / Q000187:drug effects; D007701:Kinetin; D009584:Nitrogen / Q000737:chemistry*; D010205:Pantothenic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000302:isolation & purification* / Q000494:pharmacology
D000588:Amines; D004791:Enzyme Inhibitors; D010205:Pantothenic Acid; D009584:Nitrogen; D007701:Kinetin; D003065:Coenzyme A