title: Dihydropyrazolopyrimidine inhibitors of K(V)1.5 (I(Kur)).
abstract: A series of dihydropyrazolopyrimidine inhibitors of K(V)1.5 (I(Kur)) have been identified. The synthesis, structure-activity relationships and selectivity against several other ion channels are described.
authors.affiliation: Bristol-Myers Squibb, Route 206 & Provinceline Road, PO Box 4000, Princeton, NJ 08543-4000, USA. wayne.vaccaro@bms.com
authors.forename: Wayne
authors.initials: W
authors.lastname: Vaccaro
authors.forename: Tram
authors.initials: T
authors.lastname: Huynh
authors.forename: John
authors.initials: J
authors.lastname: Lloyd
authors.forename: Karnail
authors.initials: K
authors.lastname: Atwal
authors.forename: Heather J
authors.initials: HJ
authors.lastname: Finlay
authors.forename: Paul
authors.initials: P
authors.lastname: Levesque
authors.forename: Mary Lee
authors.initials: ML
authors.lastname: Conder
authors.forename: Tonya
authors.initials: T
authors.lastname: Jenkins-West
authors.forename: Hong
authors.initials: H
authors.lastname: Shi
authors.forename: Lucy
authors.initials: L
authors.lastname: Sun
mesh_terms: D000818:Animals; D001281:Atrial Fibrillation / Q000378:metabolism; D002460:Cell Line; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D006801:Humans; D007477:Ions / Q000737:chemistry; D051379:Mice; D008956:Models, Chemical; D026902:Potassium Channel Blockers / Q000138:chemical synthesis* / Q000494:pharmacology; D024642:Potassium Channels, Voltage-Gated / Q000037:antagonists & inhibitors*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D007477:Ions; D026902:Potassium Channel Blockers; D024642:Potassium Channels, Voltage-Gated; D011743:Pyrimidines