Quantification of scattering changes using polarization-sensitive optical coherence tomography.
We demonstrate that changes in the degree of polarization (DOP) depend on changes in the scattering coefficient, and they can be quantified by using a polarization-sensitive optical coherence tomography (PS-OCT) system. We test our hypothesis using liquid and solid phantoms made from Intralipid suspensions and gelatin, respectively. We also quantify the DOP changes with depth caused by changes in the concentration of scatterers in the liquid and solid phantoms. It is clearly shown that the DOP change has a linear relationship with the scattering change. In our previous study, we showed that the axial slope of the DOP is different between normal and pathologic cervical tissues. Our results demonstrate that the quantification of the axial DOP slope can be used for the systematic diagnosis of certain tissue pathology.
Lee
Sang-Won
SW
Yonsei University, Department of Biomedical Engineering, Wonju, South Korea.
Kang
Jin-Ho
JH
Yoo
Ji-Yeong
JY
Kang
Moon-Sik
MS
Oh
Jung-Tack
JT
Kim
Beop-Min
BM
D003198:Computer Simulation; D005260:Female; D006801:Humans; D008027:Light; D008954:Models, Biological; D019047:Phantoms, Imaging; D012031:Refractometry / Q000379:methods*; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods*; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000503:physiopathology; D002578:Uterine Cervical Dysplasia / Q000473:pathology* / Q000503:physiopathology