title: Suramin: clinical uses and structure-activity relationships.
abstract: Suramin is a polysulfonated polyaromatic symmetrical urea. It is currently used to treat African river blindness and African sleeping sickness. Suramin has also been extensively trialed recently to treat a number of other diseases, including many cancers. Here, we examine its modes of action and discuss its structure-activity relationships.
authors.affiliation: School of Molecular & Microbial Sciences, The University of Queensland, Brisbane, Qld 4072, Australia. r.mcgeary@uq.edu.au
authors.forename: Ross P
authors.initials: RP
authors.lastname: McGeary
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Bennett
authors.forename: Quoc B
authors.initials: QB
authors.lastname: Tran
authors.forename: Kelly L
authors.initials: KL
authors.lastname: Cosgrove
authors.forename: Benjamin P
authors.initials: BP
authors.lastname: Ross
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D009855:Onchocerciasis / Q000188:drug therapy / Q000469:parasitology; D013329:Structure-Activity Relationship; D013498:Suramin / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use* / Q000633:toxicity; D014344:Trypanocidal Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*; D014352:Trypanosomiasis / Q000188:drug therapy / Q000469:parasitology
chemical_list: D000970:Antineoplastic Agents; D014344:Trypanocidal Agents; D013498:Suramin