Tagging SNP association study of the IL-1beta gene (IL1B) and childhood-onset mood disorders.
Given substantial evidence for IL-1beta involvement in the etiology of depression, the IL1B gene is a strong candidate for involvement in susceptibility to depressive disorders. However, association studies investigating this, to date, have been limited to just two polymorphisms (rs1143627[-31T/C] and rs16944[-511C/T]) that constitute only a fraction of the genetic variation that is actually present across this gene in the population. Here, in a family-based association study of childhood-onset mood disorders (COMD), characterized by onset of depression before the age of 15, we have used a gene-wide approach, employing a panel of five tagging SNPs spanning the entire gene. Based on TDT analyses of both individual alleles and haplotypes, in a study sample of 646 families (with 782 affected children), none of the SNPs, including those implicated in transcriptional regulation of the gene, showed evidence for association with COMD. This is the largest and most comprehensive study of IL1B in relation to mood disorders that has been carried out, to date. The results do not support the involvement of IL1B as a major factor in genetic risk for early-onset mood disorders.
Misener
Virginia L
VL
Toronto Western Research Institute, University Health Network, Ontario, Canada.
Gomez
Lissette
L
Wigg
Karen G
KG
King
Nicole
N
Kiss
Enikõ
E
Daróczi
Gabriella
G
Kapornai
Krisztina
K
Tamás
Zsuzsanna
Z
Mayer
László
L
Gádoros
Júlia
J
Baji
Ildikó
I
Kennedy
James L
JL
Kovacs
Maria
M
Vetró
Agnes
A
Barr
Cathy L
CL
D000293:Adolescent; D017668:Age of Onset; D002648:Child; D002874:Chromosome Mapping; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D015810:Linkage Disequilibrium; D008297:Male; D019964:Mood Disorders / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D035781:Siblings
C508585:IL1B protein, human; D053583:Interleukin-1beta