Development of naftifine hydrochloride alcohol-free niosome gel.
Marketed topical gels of the antifungal drug naftifine hydrochloride contain 50% alcohol as cosolvent. Repeated exposure to alcohol could be detrimental to skin. The aim of this study is to develop an alcohol-free niosome gel containing 1% naftifine hydrochloride. Niosomes were prepared and formulation variables were optimized to achieve maximum entrapment coupled with stability. Maximum drug entrapment and niosome stability entailed imparting a negative charge to the vesicles where entrapment efficiency reached 50%. Niosomes were incorporated into a hydroxyethylcellulose gel. The final gel contained a total drug concentration of 1% (wt/wt) half of which was entrapped in the niosomes. The results suggest the potential usefulness of the niosome gel.
Barakat
Heba S
HS
Faculty of Pharmacy, Department of Pharmaceutics, University of Alexandria, Azarita, Alexandria, Egypt. h_barakat76@yahoo.com
Darwish
Inas A
IA
El-Khordagui
Labiba K
LK
Khalafallah
Nawal M
NM
D000499:Allylamine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000737:chemistry; D002482:Cellulose / Q000031:analogs & derivatives; D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D005079:Excipients; D005782:Gels; D008081:Liposomes; D008855:Microscopy, Electron, Scanning; D010755:Organophosphates / Q000737:chemistry; D010316:Particle Size; D011136:Polysorbates; D013056:Spectrophotometry, Ultraviolet
D000935:Antifungal Agents; D005079:Excipients; D005782:Gels; D008081:Liposomes; D010755:Organophosphates; D011136:Polysorbates; C002290:dicetylphosphate; D000499:Allylamine; C029178:naftifine; D002482:Cellulose; C002283:hydroxyethylcellulose