A notch in the toll belt.
Two cell response pathways, Toll-like receptor (TLR) and Notch, conserved from Drosophila to mammals are well characterized for distinct roles in innate immunity and cell development, respectively. In this issue of Immunity, Hu et al. (2008) describe and characterize the direct cooperation of these two pathways.
Hertzog
Paul
P
Centre for Innate Immunity and Infectious Disease, Monash Institute of Medical Research, 27-31 Wright Street, Clayton, Victoria, Australia. Paul.Hertzog@med.monash.edu.au
D000818:Animals; D016207:Cytokines / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism; D055611:Natural Killer T-Cells / Q000276:immunology / Q000378:metabolism; D051880:Receptors, Notch / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D051193:Toll-Like Receptors / Q000276:immunology / Q000378:metabolism*
D016207:Cytokines; D051880:Receptors, Notch; D051193:Toll-Like Receptors