Helicobacter pylori virulence and the diversity of gastric cancer in Asia.
Infection with cagPAI positive strains of Helicobacter pylori is recognized as being associated with an increased risk of gastric cancer. This article reviews the current knowledge on the structures and pathological functions of cagPAI and the CagA protein, focusing especially on the molecular mechanism through which CagA may be involved in gastric carcinogenesis. The possible link between the geographical distribution of cagPAI and cagA variations and gastric cancer diversity in Asia is also discussed.
Nguyen
Lam Tung
LT
Department of Gastroenterology, Faculty of Medicine, Oita University, Oita 879-5593, Japan.|Department of Molecular Pathology, Faculty of Medicine, Oita University, Oita 879-5593, Japan.
Uchida
Tomohisa
T
Department of Human Environmental and Social Medicine, Faculty of Medicine, Oita University, Oita 879-5593, Japan.|Department of Molecular Pathology, Faculty of Medicine, Oita University, Oita 879-5593, Japan.
Murakami
Kazunari
K
Department of Gastroenterology, Faculty of Medicine, Oita University, Oita 879-5593, Japan.
Fujioka
Toshio
T
Department of Gastroenterology, Faculty of Medicine, Oita University, Oita 879-5593, Japan.
Moriyama
Masatsugu
M
Department of Molecular Pathology, Faculty of Medicine, Oita University, Oita 879-5593, Japan.
D000942:Antigens, Bacterial / Q000235:genetics; D001208:Asia / Q000453:epidemiology; D001426:Bacterial Proteins / Q000235:genetics; D005260:Female; D044404:Genomic Islands / Q000235:genetics; D016481:Helicobacter Infections / Q000150:complications* / Q000453:epidemiology* / Q000382:microbiology; D016480:Helicobacter pylori / Q000235:genetics / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000382:microbiology / Q000473:pathology; D014774:Virulence
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C080866:cagA protein, Helicobacter pylori