Suramin: clinical uses and structure-activity relationships.
Suramin is a polysulfonated polyaromatic symmetrical urea. It is currently used to treat African river blindness and African sleeping sickness. Suramin has also been extensively trialed recently to treat a number of other diseases, including many cancers. Here, we examine its modes of action and discuss its structure-activity relationships.
McGeary
Ross P
RP
School of Molecular & Microbial Sciences, The University of Queensland, Brisbane, Qld 4072, Australia. r.mcgeary@uq.edu.au
Bennett
Andrew J
AJ
Tran
Quoc B
QB
Cosgrove
Kelly L
KL
Ross
Benjamin P
BP
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D009855:Onchocerciasis / Q000188:drug therapy / Q000469:parasitology; D013329:Structure-Activity Relationship; D013498:Suramin / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use* / Q000633:toxicity; D014344:Trypanocidal Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*; D014352:Trypanosomiasis / Q000188:drug therapy / Q000469:parasitology
D000970:Antineoplastic Agents; D014344:Trypanocidal Agents; D013498:Suramin