title: One-pot desymmetrizing hydroformylation/carbonyl ene cyclization process: straightforward access to highly functionalized cyclohexanols.
abstract: Rapid access to highly functionalized alkylidene cyclohexanols through a one-pot desymmetrizing hydroformylation/carbonyl ene cyclization starting from simple bisalkenylcarbinols is reported. Mechanistic insight into the carbonyl ene reaction is given, highlighting the importance of hyperconjugative substituent effects.
authors.affiliation: Institut für Organische Chemie und Biochemie, Albert-Ludwigs-Universität Freiburg, Albertstrasse 21, D-79104 Freiburg, Germany.
authors.forename: Aurélien
authors.initials: A
authors.lastname: Bigot
authors.forename: Daniel
authors.initials: D
authors.lastname: Breuninger
authors.forename: Bernhard
authors.initials: B
authors.lastname: Breit
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D003500:Cyclization; D003511:Cyclohexanols / Q000737:chemistry*; D004952:Esters / Q000737:chemistry; D005296:Ferrous Compounds / Q000737:chemistry; D007700:Kinetics; D000075163:Metallocenes; D000432:Methanol / Q000737:chemistry
chemical_list: D000475:Alkenes; D003511:Cyclohexanols; D004952:Esters; D005296:Ferrous Compounds; D000075163:Metallocenes; C004998:ferrocene; D000432:Methanol