Acute renal failure due to visceral leishmaniasis by Leishmania infantum successfully treated with a single high dose of liposomal amphotericin B.
We report a visceral leishmaniasis case in an immunocompetent immigrant with acute renal failure. Parasites were demonstrated in bone marrow, peripheral blood, and kidney samples. A collapsing focal segmental glomerulosclerosis was documented, which was successfully treated with a single infusion of 10 mg/kg liposomal amphotericin B.
Beltrame
Anna
A
Clinic of Infectious Diseases, Department of Clinical and Morphological Research, University of Udine, Udine, Italy. beltrame.anna@aoud.sanita.ivg.it
Arzese
Alessandra
A
Camporese
Alessandro
A
Rorato
Giada
G
Crapis
Massimo
M
Tarabini-Castellani
Giuseppe
G
Boscutti
Giuliano
G
Pizzolitto
Stefano
S
Calianno
Giuseppina
G
Matteelli
Alberto
A
Di Muccio
Trentina
T
Gramiccia
Marina
M
Viale
Pierluigi
P
D058186:Acute Kidney Injury / Q000188:drug therapy* / Q000382:microbiology*; D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage*; D000810:Angola; D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005921:Glomerulonephritis / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D007558:Italy; D018314:Leishmania infantum / Q000302:isolation & purification; D007898:Leishmaniasis, Visceral / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D008297:Male; D014195:Travel; D016896:Treatment Outcome
D000981:Antiprotozoal Agents; C068538:liposomal amphotericin B; D000666:Amphotericin B