title: Underlying histopathology of HIV-infected women with squamous cell abnormalities on cervical cytology.
abstract: This study was undertaken to evaluate the underlying histopathology of HIV-infected women who had abnormal cervical cytology. HIV-infected women with abnormal cervical cytology undergoing colposcopy at Chiang Mai University Hospital between January 2001 and February 2008 were reviewed. The cohorts were matched and compared with an HIV-negative group. During the study period, 65 HIV-infected women with abnormal cervical cytology were available for review. The abnormal cervical smears were atypical squamous cell (9), low-grade squamous intraepithelial lesion (22), high-grade squamous intraepithelial lesion (27), and squamous cell carcinoma (7). When stratified by severity of abnormal cytology, HIV-infected women had a higher risk of having cervical intraepithelial neoplasia II or higher, whether the cervical smear showed low-grade (P=0.01) or high-grade abnormality (P=0.04) compared with the HIV negative group. After adjustment by age, parity, and menopausal status, HIV-infected women had 2.56 times the risk of having CIN II or higher (69.2% of HIV-infected women compared with 47.7% of HIV negative women; 95% CI=1.21-5.40, P=0.01). In conclusion, HIV-infected women with abnormal Pap smears are a population subset with a higher risk of significant cervical lesions, irrespective of the severity of abnormal cervical smears.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. jjnnssjj@yahoo.com
authors.forename: Nongyao
authors.initials: N
authors.lastname: Suwankanta
authors.forename: Chumnan
authors.initials: C
authors.lastname: Kietpeerakool
authors.forename: Jatupol
authors.initials: J
authors.lastname: Srisomboon
authors.forename: Surapan
authors.initials: S
authors.lastname: Khunamornpong
authors.forename: Sumalee
authors.initials: S
authors.lastname: Siriaunkgul
mesh_terms: D000328:Adult; D017677:Age Distribution; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000473:pathology* / Q000821:virology; D016022:Case-Control Studies; D003127:Colposcopy; D016001:Confidence Intervals; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology*; D006679:HIV Seropositivity / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D016015:Logistic Models; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D065006:Papanicolaou Test; D011336:Probability; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D013785:Thailand; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000473:pathology*; D014626:Vaginal Smears; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology / Q000473:pathology* / Q000821:virology