Synthesis and anti-angiogenic activity of cortistatin analogs.
Analogs of cortistatins, a series of anti-angiogenic compounds isolated from the Indonesian marine sponge Cortisium simplex, were synthesized from estrone by using the Suzuki-Miyaura coupling reaction as the key step. The estrone-isoquinoline hybridized compound showed selective inhibitory activity against the proliferation and VEGF-induced migration of HUVEC.
Sato
Yuuki
Y
Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
Kamiyama
Hiroshi
H
Usui
Takeo
T
Saito
Tamio
T
Osada
Hiroyuki
H
Kuwahara
Shigefumi
S
Kiyota
Hiromasa
H
D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D002460:Cell Line; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects; D004970:Estrone / Q000031:analogs & derivatives; D006801:Humans; D051379:Mice; D009479:Neuropeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D042461:Vascular Endothelial Growth Factor A / Q000494:pharmacology
D020533:Angiogenesis Inhibitors; D009479:Neuropeptides; D042461:Vascular Endothelial Growth Factor A; C099323:cortistatin; D004970:Estrone