title: Ultralow fouling zwitterionic polymers grafted from surfaces covered with an initiator via an adhesive mussel mimetic linkage.
abstract: In this work, nonfouling zwitterionic polymers were grafted via surface-initiated atom transfer radical polymerization (ATRP) from surfaces covered with an adhesive catechol initiator. The catechol initiator was attached to both bare gold and amino-functionalized surfaces, and the nonfouling performances of the resulting polymer brushes were compared. Under optimal conditions, ultralow protein adsorption from both single-protein solutions of fibrinogen and lysozyme and complex media of 10% blood serum and 100% blood plasma/serum was achieved. Furthermore, the 3-day accumulation of Pseudomonas aeruginosa on the treated glass surfaces was studied in situ using a laminar flow chamber. The results showed that these zwitterionic coatings dramatically reduced the biofilm formation of P. aeruginosa as compared to the reference bare glass.
authors.affiliation: Department of Chemical Engineering, University of Washington, Seattle, Washington 98195, USA.
authors.forename: Guozhu
authors.initials: G
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: Xue
authors.forename: Gang
authors.initials: G
authors.lastname: Cheng
authors.forename: Shengfu
authors.initials: S
authors.lastname: Chen
authors.forename: Fengbao
authors.initials: F
authors.lastname: Zhang
authors.forename: Shaoyi
authors.initials: S
authors.lastname: Jiang
mesh_terms: D000327:Adsorption; D000818:Animals; D001422:Bacterial Adhesion / Q000187:drug effects; D018441:Biofilms / Q000187:drug effects; D032701:Biomimetics; D049872:Bivalvia / Q000737:chemistry*; D002396:Catechols / Q000737:chemistry; D005340:Fibrinogen / Q000737:chemistry; D005898:Glass; D006046:Gold; D007202:Indicators and Reagents; D008856:Microscopy, Fluorescence; D009113:Muramidase / Q000097:blood / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013499:Surface Properties
chemical_list: D002396:Catechols; D007202:Indicators and Reagents; D011108:Polymers; D006046:Gold; D005340:Fibrinogen; D009113:Muramidase