FHM3 in familial hemiplegic migraine is more resistant to mutation than FHM1 and FHM2.
Familial hemiplegic migraine (FHM) is a rare subtype of migraine with aura and transient hemiplegia. CACNA1A (FHM1) gene, the ATP1A2 (FHM2) and the SCN1A (FHM3) are reported for their correlation to FHM. Here, a bioinformatics analysis was done to study the risk positions for mutation within the amino acid sequence of the three mentioned molecules. In this work, the author can identify many mutant prone positions within the studied FHM. Of interest, the author detected that FHM3 is a high resistant molecule when compared to FHM1 and FHM2.
Wiwanitkit
Viroj
V
Wiwanitkit House, Bangkhae, Bangkok, 10160, Thailand. wviroj@yahoo.com
D000595:Amino Acid Sequence; D015220:Calcium Channels / Q000235:genetics*; D019295:Computational Biology; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D006801:Humans; D020325:Migraine with Aura / Q000145:classification / Q000453:epidemiology* / Q000235:genetics*; D008969:Molecular Sequence Data; D062550:NAV1.1 Voltage-Gated Sodium Channel; D009419:Nerve Tissue Proteins / Q000235:genetics*; D012307:Risk Factors; D015222:Sodium Channels / Q000235:genetics*; D000254:Sodium-Potassium-Exchanging ATPase / Q000235:genetics*; D020864:Calcium Channels, N-Type
D015220:Calcium Channels; D062550:NAV1.1 Voltage-Gated Sodium Channel; D009419:Nerve Tissue Proteins; D015222:Sodium Channels; D000254:Sodium-Potassium-Exchanging ATPase; C105656:CACNA1A protein, human; D020864:Calcium Channels, N-Type; C568242:SCN1A protein, human; C498531:ATP1A2 protein, human