title: 2-Azetidinone derivatives: design, synthesis and evaluation of cholesterol absorption inhibitors.
abstract: Fourteen new derivatives of the 2-azetidinone cholesterol absorption inhibitors have been synthesized, and three of them were enantiomerically pure. All the new compounds were evaluated for their activity to inhibit cholesterol absorption in rats, and most of them showed comparable effects in lowering the levels of total cholesterol in the serum.
authors.affiliation: New Drug Research Center, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China.
authors.forename: Yubin
authors.initials: Y
authors.lastname: Wang
authors.forename: Huibin
authors.initials: H
authors.lastname: Zhang
authors.forename: Wenlong
authors.initials: W
authors.lastname: Huang
authors.forename: Jing
authors.initials: J
authors.lastname: Kong
authors.forename: Jinpei
authors.initials: J
authors.lastname: Zhou
authors.forename: Beibei
authors.initials: B
authors.lastname: Zhang
mesh_terms: D000042:Absorption / Q000187:drug effects; D000818:Animals; D001384:Azetidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002784:Cholesterol / Q000378:metabolism*; D006224:Cricetinae; D015195:Drug Design; D008297:Male
chemical_list: C116379:2-azetidinone; D001384:Azetidines; D002784:Cholesterol