Differential regulation of VEGF after final oocyte maturation with GnRH agonist versus hCG: a rationale for OHSS reduction.
In a prospective cohort study, we compared the effect of hCG and GnRH agonist triggering of final oocyte maturation on vascular endothelial growth factor production. Vascular endothelial growth factor follicular fluid concentration was significantly lower in response to GnRH agonist versus hCG, which may partially explain the absence of OHSS in these of women.
Cerrillo
Maria
M
IVI-Madrid, Madrid, Spain.
Rodríguez
Sara
S
Mayoral
Mercedes
M
Pacheco
Alberto
A
Martínez-Salazar
Javier
J
Garcia-Velasco
Juan A
JA
D000293:Adolescent; D000328:Adult; D002454:Cell Differentiation / Q000187:drug effects; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D015331:Cohort Studies; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D015571:Follicular Fluid / Q000378:metabolism*; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D003341:Luteolysis / Q000187:drug effects; D018587:Oocyte Donation / Q000379:methods; D009865:Oocytes / Q000166:cytology / Q000187:drug effects; D009866:Oogenesis / Q000187:drug effects*; D016471:Ovarian Hyperstimulation Syndrome / Q000517:prevention & control*; D010063:Ovum / Q000166:cytology / Q000187:drug effects; D011446:Prospective Studies; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods; D017329:Triptorelin Pamoate / Q000494:pharmacology*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D055815:Young Adult
D006063:Chorionic Gonadotropin; D042461:Vascular Endothelial Growth Factor A; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone