title: Hepatic derangement following N-Acetylcysteine enemas in an infant with cystic fibrosis.
abstract: We discuss an infant with MI secondary to cystic fibrosis, who was managed surgically by a double barrel ileostomy for mid - small bowel atresia and developed severe faecal impaction in the post - operative period. The faecal impaction was treated successfully with oral NAC and 0.2% NAC contrast enemas. The patient's liver function tests revealed a dramatic increase in transaminases and bilirubin contemporaneous with the administration of the enemas. The levels showed a spontaneous improvement after discontinuation. This is only the second reported case of hepatotoxicity secondary to NAC enemas in the literature. While our experience offers modest support for the use of NAC, its efficacy is not yet proven and paediatric surgeons using NAC in the enema form need to closely monitor liver function contemporaneous with this agent's administration and adjust their treatment accordingly.
authors.affiliation: Department of Paediatric Surgery, The Children's Hospital at Westmead, New South Wales, Australia. acoo9616@gmp.usyd.edu.au
authors.forename: Andrew
authors.initials: A
authors.lastname: Cooke
authors.forename: Aniruddh V
authors.initials: AV
authors.lastname: Deshpande
authors.forename: Chris K F
authors.initials: CK
authors.lastname: Wong
authors.forename: Ralph
authors.initials: R
authors.lastname: Cohen
mesh_terms: D000111:Acetylcysteine / Q000008:administration & dosage / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury; D003550:Cystic Fibrosis; D004733:Enema; D005244:Fecal Impaction / Q000188:drug therapy; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D045823:Ileus / Q000188:drug therapy; D007231:Infant, Newborn; D008470:Meconium / Q000187:drug effects
chemical_list: D016166:Free Radical Scavengers; D000111:Acetylcysteine