Synthesis and enantiomeric resolution of (+/-)-pinocembrin.
A convenient method for the synthesis and enantiomeric resolution of ( +/- )-pinocembrin has been developed. This route involves the hydrogenation of 5,7-dihydroxyflavone, the derivatization of racemic pinocembrin with chiral amine, and the separation of the diastereoisomers due to their different physical properties.
Yuan
Yue
Y
Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.
Yang
Qing-Yun
QY
Tong
Yuan-Feng
YF
Chen
Feng
F
Qi
Yan
Y
Duan
Ya-Bo
YB
Wu
Song
S
D044950:Flavanones / Q000138:chemical synthesis*; D015394:Molecular Structure
D044950:Flavanones; C016063:pinocembrin