Cofilin immunolabelling correlates with depth of invasion in gastrointestinal endocrine cell tumors.
Gastrointestinal endocrine cell tumors are a heterogeneous population of lesions believed to arise from neuroendocrine cells of the gastrointestinal mucosa. The current classification of these tumors is based on tumor size, microscopic features and clinical evidence of metastasis. Although diagnostic categories generally correlate with prognosis, molecular prognostic markers will be clinically useful adjuncts. Cofilin has been implicated in tumor invasion, and its immunolocalisation was studied in gastrointestinal endocrine cell tumors. The immunolocalisation of cofilin was studied by immunohistochemistry in 34 formalin-fixed, paraffin wax-embedded gastrointestinal endocrine cell tumors using a tissue microarray platform. A significant correlation was found between high cofilin immunolabelling and the depth of invasion (p<0.05). Our findings suggest that cofilin might be useful clinically as a molecular prognostic adjunct in the evaluation of gastrointestinal endocrine cell tumors.
Yan
Benedict
B
Department of Pathology, National University Hospital and Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Yap
Celestial T
CT
Wang
Shi
S
Lee
Chi Kuen
CK
Koh
Shiuan
S
Omar
Mohd Feroz
MF
Salto-Tellez
Manuel
M
Kumarasinghe
Marian Priyanthi
MP
D051339:Actin Depolymerizing Factors / Q000378:metabolism*; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002277:Carcinoma / Q000378:metabolism / Q000473:pathology; D004701:Endocrine Gland Neoplasms / Q000378:metabolism* / Q000473:pathology*; D019858:Enteroendocrine Cells / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000378:metabolism / Q000473:pathology; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology; D055815:Young Adult
D051339:Actin Depolymerizing Factors; D014408:Biomarkers, Tumor