title: Glycosylated hemoglobin and risk of colorectal cancer in men and women, the European prospective investigation into cancer and nutrition.
abstract: Although large-scale prospective cohort studies have related hyperglycemia to increased risk of cancer overall, studies specifically on colorectal cancer have been generally small. We investigated the association between prediagnostic levels of glycosylated hemoglobin (HbA1c), a marker for average glucose level in blood, and colorectal cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort. One thousand and twenty-six incident colorectal cancer cases (561 men and 465 women) and 1,026 matched controls were eligible for the study. Multivariate conditional logistic regression was used to estimate odds ratios (ORS) adjusted for possible confounders. Increasing HbA1c percentages were statistically significantly associated with a mild increase in colorectal cancer risk in the whole population [OR, 1.10; 95% confidence interval (CI), 1.01,1.19 for a 10% increase in HbA1c]. In women, increasing HbA1c percentages were associated with a statistically significant increase in colorectal cancer risk (OR, 1.16; 95% CI, 1.01, 1.32 for a 10% increase in HbA1c) and with a borderline statistically significant increase in rectum cancer (OR, 1.22; 95% CI, 0.99,1.50 for a 10% increase in HbA1c). No significant association with cancer risk was observed in men. The results of the current study suggest a mild implication of hyperglycemia in colorectal cancer, which seems more important in women than in men, and more for cancer of the rectum than of the colon.
authors.affiliation: IARC, 150, cours Albert Thomas, Lyon, 69372 Lyon Cedex 08, France. Rinaldi@iarc.fr
authors.forename: Sabina
authors.initials: S
authors.lastname: Rinaldi
authors.forename: Sabine
authors.initials: S
authors.lastname: Rohrmann
authors.forename: Mazda
authors.initials: M
authors.lastname: Jenab
authors.forename: Carine
authors.initials: C
authors.lastname: Biessy
authors.forename: Sabina
authors.initials: S
authors.lastname: Sieri
authors.forename: Domenico
authors.initials: D
authors.lastname: Palli
authors.forename: Rosario
authors.initials: R
authors.lastname: Tumino
authors.forename: Amalla
authors.initials: A
authors.lastname: Mattiello
authors.forename: Paolo
authors.initials: P
authors.lastname: Vineis
authors.forename: Alexandra
authors.initials: A
authors.lastname: Nieters
authors.forename: Jakob
authors.initials: J
authors.lastname: Linseisen
authors.forename: Tobias
authors.initials: T
authors.lastname: Pischon
authors.forename: Heiner
authors.initials: H
authors.lastname: Boeing
authors.forename: Göran
authors.initials: G
authors.lastname: Hallmans
authors.forename: Richard
authors.initials: R
authors.lastname: Palmqvist
authors.forename: Jonas
authors.initials: J
authors.lastname: Manjer
authors.forename: Elisabet
authors.initials: E
authors.lastname: Wirfält
authors.forename: Francesca L
authors.initials: FL
authors.lastname: Crowe
authors.forename: Kay-Tee T
authors.initials: KT
authors.lastname: Khaw
authors.forename: Sheila
authors.initials: S
authors.lastname: Bingham
authors.forename: Anne
authors.initials: A
authors.lastname: Tjønneland
authors.forename: Anja
authors.initials: A
authors.lastname: Olsen
authors.forename: Kim
authors.initials: K
authors.lastname: Overvad
authors.forename: Eiliv
authors.initials: E
authors.lastname: Lund
authors.forename: Guri
authors.initials: G
authors.lastname: Skeie
authors.forename: Francoise
authors.initials: F
authors.lastname: Clavel-Chapelon
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Boutron-Ruault
authors.forename: Blandine
authors.initials: B
authors.lastname: de Lauzon-Guillain
authors.forename: Eva
authors.initials: E
authors.lastname: Ardanaz
authors.forename: Paula
authors.initials: P
authors.lastname: Jakszyn
authors.forename: Jose
authors.initials: J
authors.lastname: Ramon Quiros
authors.forename: Maria-Dolores
authors.initials: MD
authors.lastname: Chirlaque
authors.forename: Maria-Jose
authors.initials: MJ
authors.lastname: Sanchez
authors.forename: Miren
authors.initials: M
authors.lastname: Dorronsoro
authors.forename: Antonia
authors.initials: A
authors.lastname: Trichopoulou
authors.forename: Pagona
authors.initials: P
authors.lastname: Lagiou
authors.forename: Dimitrious
authors.initials: D
authors.lastname: Trichopoulos
authors.forename: H Bas
authors.initials: HB
authors.lastname: Bueno-de-Mesquita
authors.forename: Fränzel J B
authors.initials: FJ
authors.lastname: van Duijnhoven
authors.forename: Petra H M
authors.initials: PH
authors.lastname: Peeters
authors.forename: Nadia
authors.initials: N
authors.lastname: Slimani
authors.forename: Pietro
authors.initials: P
authors.lastname: Ferrari
authors.forename: Graham B
authors.initials: GB
authors.lastname: Byrnes
authors.forename: Elio
authors.initials: E
authors.lastname: Riboli
authors.forename: Rudolf
authors.initials: R
authors.lastname: Kaaks
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D001786:Blood Glucose / Q000032:analysis; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002851:Chromatography, High Pressure Liquid; D015179:Colorectal Neoplasms / Q000097:blood* / Q000453:epidemiology*; D005060:Europe / Q000453:epidemiology; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D006943:Hyperglycemia / Q000097:blood* / Q000453:epidemiology*; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018570:Risk Assessment; D012737:Sex Factors; D011795:Surveys and Questionnaires
chemical_list: D014408:Biomarkers, Tumor; D001786:Blood Glucose; D006442:Glycated Hemoglobin