[The expression of collagen I during mandibular fracture healing with the inferior alveolar nerve mutilated].
OBJECTIVE
To establish a stable mandibular fracture model with inferior alveolar nerve (IAN) mutilated for exploring the IAN influence to the expression of collagen I during mandibular fracture.


METHODS
Japanese white rabbits were selected and IAN was liberated. The right was leaven as it is and the left was cut off, then 2 mm x 5 mm fracture model was made, and HE staining and chromotropic acid 2R-bright green staining and in situ hybridization of collagen I mRNA were made to detect mandibular fracture healing and collagen I mRNA expression.


RESULTS
Fracture healing was smooth in IAN conserved side, but delayed in the IAN mutilated side. Collagen I in situ hybridization showed that at one week and two weeks after surgery there were obvious differences between the two sides (P < 0.05), but no difference at three weeks after surgery and four weeks (P > 0.05).


CONCLUSIONS
The IAN could regulate mandibular fracture healing, and influence collagen I mRNA earlier expression.
Zhang
Wei
W
Dept. of Oral and Maxillofacial Surgery, Stomatological Hospital, Jilin University, Changchun 130041, China.
Liu
Qi-lin
QL
Yu
Zi-ying
ZY
Wang
Wei-min
WM
Sun
Bin
B
D000818:Animals; D003094:Collagen; D008334:Mandible; D008337:Mandibular Fractures; D008340:Mandibular Nerve; D011817:Rabbits
D003094:Collagen