title: Preparation and stability of voriconazole eye drop solution.
abstract: The combined systemic and topical administration of voriconazole has successfully been used to treat keratomycosis. Because no voriconazole eye drop product is commercially available, we prepared a sterile eye drop solution (10 mg/ml). Voriconazole remains stable over 30 days, providing an eye drop solution suitable for use for the topical treatment of fungal keratitis.
authors.affiliation: Centre Hospitalier Universitaire de Poitiers, France. Antoine.Dupuis@univ-poitiers.fr
authors.forename: Antoine
authors.initials: A
authors.lastname: Dupuis
authors.forename: Nicolas
authors.initials: N
authors.lastname: Tournier
authors.forename: Gwenaël
authors.initials: G
authors.lastname: Le Moal
authors.forename: Nicolas
authors.initials: N
authors.lastname: Venisse
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding; D004355:Drug Stability; D005079:Excipients; D006863:Hydrogen-Ion Concentration; D009883:Ophthalmic Solutions; D011743:Pyrimidines / Q000008:administration & dosage / Q000494:pharmacology*; D014230:Triazoles / Q000008:administration & dosage / Q000494:pharmacology*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D005079:Excipients; D009883:Ophthalmic Solutions; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole