Screening approaches for chiral separations.
The publications of the past 10 years in which generic screening approaches or separation strategies were developed in the field of chiral separations are reviewed. The idea is to give an overview of the different techniques that were used along with the possibilities of performing chiral separations applying these techniques. Research papers in which generic conditions are defined, that is, applicable on large sets of structurally diverse substances, either as a screening experiment or as a strategy including some optimization possibilities after the screening step, were considered. This should allow giving the reader an idea about the techniques used in the chiral separation field that enable generic analysis and about the conditions that can be considered as a first step in chiral method development.
Mangelings
Debby
D
Department of Analytical Chemistry and Pharmaceutical Technology, Vrije Universiteit Brussel, Brussels, Belgium.
Vander Heyden
Yvan
Y
D053801:Capillary Electrochromatography / Q000379:methods; D002845:Chromatography / Q000379:methods*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002853:Chromatography, Liquid / Q000379:methods; D025924:Chromatography, Supercritical Fluid / Q000379:methods; D019075:Electrophoresis, Capillary / Q000379:methods; D013237:Stereoisomerism