Alpha-S-GalCer: synthesis and evaluation for iNKT cell stimulation.
The synthesis and evaluation for iNKT stimulation of alpha-S-galactosylceramide is reported. Prepared by alkylation of a galactosylthiol, this analog of the potent immunostimulatory agent, KRN7000, did not stimulate iNKT cells either in vitro or in vivo.
Blauvelt
Marisa L
ML
Department of Chemistry, University of Connecticut, 55 N. Eagleville Road, Storrs, CT 06269-3060, USA.
Khalili
Maryam
M
Jaung
Weonjoo
W
Paulsen
Janet
J
Anderson
Amy C
AC
Brian Wilson
S
S
Howell
Amy R
AR
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D005699:Galactosylceramides / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology*; D006017:Glycolipids / Q000737:chemistry; D006801:Humans; D006860:Hydrogen Bonding; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D008956:Models, Chemical; D010100:Oxygen / Q000737:chemistry; D012995:Solubility; D013438:Sulfhydryl Compounds / Q000737:chemistry
D000970:Antineoplastic Agents; D005699:Galactosylceramides; D006017:Glycolipids; D013438:Sulfhydryl Compounds; C493154:alpha-galactosylceramide; D010100:Oxygen; C103873:KRN 7000