Ainsliatrimers A and B, the first two guaianolide trimers from Ainsliaea fulvioides.
Ainsliatrimers A (1) and B (2), the first two guaianolide-type sesquiterpene lactone trimers, together with one new structurally related sesquiterpene dimer ainsliadimer B (3), were isolated from the aerial part of Ainsliaea fulvioides. Their structures were elucidated by spectroscopic techniques, including X-ray crystal diffraction. Both 1 and 2 showed potent cytotoxicites against LOVO and CEM cell lines.
Wang
Yan
Y
School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China.
Shen
Yun-Heng
YH
Jin
Hui-Zi
HZ
Fu
Jian-Jun
JJ
Hu
Xiao-Jia
XJ
Qin
Jiang-Jiang
JJ
Liu
Jian-Hua
JH
Chen
Ming
M
Yan
Shi-Kai
SK
Zhang
Wei-Dong
WD
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry* / Q000378:metabolism; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008968:Molecular Conformation; D035261:Plant Components, Aerial / Q000737:chemistry / Q000378:metabolism; D045789:Sesquiterpenes, Guaiane / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014961:X-Ray Diffraction
D000972:Antineoplastic Agents, Phytogenic; D045789:Sesquiterpenes, Guaiane; C543081:ainsliatrimer A; C543082:ainsliatrimer B