title: Contrast-enhanced magnetic resonance angiography: evaluation of the high relaxivity low diffusible gadolinium-based contrast agent P846 in comparison with gadoterate meglumine in rabbits at 1.5 Tesla and 3.0 Tesla.
abstract: OBJECTIVE
  To evaluate the gadolinium-based contrast agent P846 and compare it with gadoterate meglumine (Gd-DOTA) for contrast-enhanced magnetic resonance angiography (MRA) in rabbits at 1.5 T and 3.0 T, respectively.
  
  
  METHODS
  Five rabbits underwent contrast-enhanced MRA of the abdominal vasculature applying gadolinium doses of 0.025 mmoL/kg for P846 and 0.1 mmoL/kg for Gd-DOTA, respectively. All animals were examined on a 1.5-T and 3.0-T MR system. Image data were acquired during the first-pass arterial phase and repeatedly over 10 minutes. Contrast-to-noise-ratio (CNR) was determined in the aorta, the inferior vena cava, and the renal cortex. Image quality of arterial phase MR angiograms was consensually judged on a 5-point scale (5 = high).
  
  
  RESULTS
  Contrast-enhanced MRA was successful in all cases with both contrast agents. CNR values consistently proved statistically significantly higher for P846 compared with Gd-DOTA. CNR values in the aorta during the arterial phase were 46.0 +/- 3.7 (P846) and 28.0 +/- 3.2 (Gd-DOTA) at 1.5 T (P < 0.05), and correspondingly 89.3 +/- 12.7 (P846) and 64.1 +/- 15.0 (Gd-DOTA) at 3.0 T (P < 0.05). Image quality of arterial phase MR angiograms was rated with scores of 4.8 +/- 0.4 (P846) and 4.0 +/- 0.0 (Gd-DOTA) at 1.5 T (P = 0.06), and 5.0 +/- 0.0 (P846) and 4.8 +/- 0.4 (Gd-DOTA) at 3.0 T (P = 0.42), respectively.
  
  
  CONCLUSIONS
  The contrast agent P846 provides high contrast enhancement and image quality for contrast-enhanced MRA in rabbits at 1.5 T and 3.0 T with a 4-fold lower gadolinium dose compared with a standard extracellular contrast agent.
authors.affiliation: Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. k.peldschus@uke.uni-hamburg.de
authors.forename: Kersten
authors.initials: K
authors.lastname: Peldschus
authors.forename: Mareike
authors.initials: M
authors.lastname: Hamdorf
authors.forename: Philippe
authors.initials: P
authors.lastname: Robert
authors.forename: Marc
authors.initials: M
authors.lastname: Port
authors.forename: Joachim
authors.initials: J
authors.lastname: Graessner
authors.forename: Gerhard
authors.initials: G
authors.lastname: Adam
authors.forename: Christoph U
authors.initials: CU
authors.lastname: Herborn
mesh_terms: D000818:Animals; D001012:Aorta, Abdominal / Q000033:anatomy & histology*; D003287:Contrast Media; D005260:Female; D007089:Image Enhancement / Q000379:methods*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008536:Meglumine; D009942:Organometallic Compounds; D051381:Rats; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C531154:P846 compound; D008536:Meglumine; C072417:gadoterate meglumine