[Molecular-genetic and epidemiologic examination of personnel subjected to occupational irradiation in Russian Federal Nuclear Center (Sarov). Report 3. Genetic characteristics of adaptive norm].
Was undertaken the effort to define the limits of the adaptive norms and of high risk groups in regard to the work connected with fissile materials (FM), radioactive materials (RM) and ionizing radiation sources (IRS). In view of the aforementioned goal it was made a comparative evaluation of the individual radiosensitivity measurements and anthropometric indicators in the cohort formed from VNIIEF personnel, which was exposed to a constant occupational gamma-neutron irradiation, as well as the non-irradiated cohort. There were analyzed the dispersion dependencies on height, on chest and on head circumference and heterozygosis by 9 loci. It was found that the minimum chest circumference dispersion is observed in people with average heterozygosis equal to 3 (at the 95% credibility). The minimum head circumference and height dispersion is observed in people with average heterozygosis equal to 3-5. The largest jitter in metric indicators is characteristic for people with heterozygosis 2. The highest radiosensitivity is typical for such individuals as well. It was formulated the assumption that this category of people present the limit heterozygosis case. So, additional research looking at people with the limit heterozygosis values (2 and 7; 8) is required, in order to define individual radiosensitivity limits.
Korzeneva
I B
IB
Malinina
T V
TV
Afanas'ev
K I
KI
Zaichkina
S I
SI
Dubrova
Iu E
IuE
Skorodumova
E N
EN
Samsonova
V F
VF
Volkova
I V
IV
Shishova
R T
RT
Shcherbakova
I L
IL
D000047:Academies and Institutes; D000293:Adolescent; D000328:Adult; D000886:Anthropometry; D015331:Cohort Studies; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays / Q000009:adverse effects*; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D009686:Nuclear Physics; D016273:Occupational Exposure / Q000009:adverse effects / Q000032:analysis / Q000592:standards; D011110:Polymorphism, Genetic; D011836:Radiation Tolerance / Q000235:genetics / Q000502:physiology / Q000528:radiation effects; D012426:Russia; D055815:Young Adult