Combined liver-kidney transplantation in children: indications and outcome.
Although it remains a relatively infrequent procedure in children, CLKT has become a viable option for a select group of pediatric patients with severe liver and kidney disease. Most are performed for rare primary diseases such as PH1, but a selected few are performed in the setting of concomitant hepatic and renal failure of uncertain etiology and prognosis. This article reviews the indications for and outcomes following CLKT in children. While it focuses on the specific primary diseases which impact liver and kidney function simultaneously, it addresses the indications based on concomitant hepatic and renal failure, such as seen in the hepatorenal syndrome, as well.
Sutherland
Scott M
SM
Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA. suthersm@stanford.edu
Alexander
Steven R
SR
Sarwal
Minnie M
MM
Berquist
William E
WE
Concepcion
Waldo
W
D000208:Acute Disease; D000328:Adult; D002648:Child; D006084:Graft Rejection; D006085:Graft Survival; D006530:Hepatorenal Syndrome / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis / Q000628:therapy; D016030:Kidney Transplantation / Q000379:methods*; D008107:Liver Diseases / Q000175:diagnosis / Q000628:therapy; D016031:Liver Transplantation / Q000379:methods*; D011379:Prognosis; D016896:Treatment Outcome