title: Supraaortic arteries: contrast material dose reduction at 3.0-T high-spatial-resolution MR angiography--feasibility study.
abstract: OBJECTIVE
  To evaluate and compare the diagnostic image quality resulting from three contrast agent dose regimens for 3.0-T high-spatial-resolution three-dimensional magnetic resonance (MR) angiography of the supraaortic arteries.
  
  
  METHODS
  Institutional review board approval was obtained; informed consent was waived for this HIPAA-compliant study. One hundred twenty consecutive patients who underwent 3.0-T three-dimensional high-spatial-resolution contrast material-enhanced MR angiography of the supraaortic arteries with an identical acquisition protocol were assigned to either the high-dose (0.154 mmol per kilogram of body weight), intermediate-dose (0.097 mmol/kg), or low-dose (0.047 mmol/kg) group. Two readers evaluated resulting images for arterial definition, venous contamination, and arterial stenosis. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were evaluated at six consistent sites. Statistical analysis was performed with the Kruskal-Wallis, Wilcoxon signed rank, and analysis of variance tests and the kappa coefficient.
  
  
  RESULTS
  Readers 1 and 2 scored vascular definition as excellent or sufficient for diagnosis in 1311 of 1360 segments and in 1313 of 1360 segments in the high-dose group (kappa = 0.73), in 1321 of 1354 and in 1319 of 1354 segments in the intermediate-dose group (kappa = 0.77), and in 1322 of 1350 and in 1320 of 1350 segments in the low-dose group (kappa= 0.66), respectively. Arterial occlusive disease was detected by reader 1 in 52, 27, and 98 segments in the high-, intermediate-, and low-dose groups, respectively. Arterial occlusive disease was detected by reader 2 in 48, 25, and 100 segments in high-, intermediate-, and low-dose groups, respectively. No significant difference existed among the three groups regarding arterial definition scores (reader 1, P = .21; reader 2, P = .25) and venous contamination scores (reader 1, P = .38; reader 2, P = .35). SNRs and CNRs were lower in the low-dose group (P < .01).
  
  
  CONCLUSIONS
  At 3.0 T, high-spatial-resolution MR angiography of the supraaortic arteries can be performed with contrast agent doses as low as 0.047 mmol/kg, without compromising image quality, acquisition speed, or spatial resolution.
  
  
  BACKGROUND
  http://radiology.rsnajnls.org/cgi/content/full/249/3/980/DC1http://radiology.rsnajnls.org/cgi/content/full/249/3/980/DC2.
authors.affiliation: Department of Radiological Sciences, David Geffen School of Medicine, University of California at Los Angeles, Suite 3371, Peter V. Ueberroth Building, 10945 Le Conte Ave, Los Angeles, CA 90095-7206, USA. atomasian@mednet.ucla.edu
authors.forename: Anderanik
authors.initials: A
authors.lastname: Tomasian
authors.forename: Noriko
authors.initials: N
authors.lastname: Salamon
authors.forename: Derek G
authors.initials: DG
authors.lastname: Lohan
authors.forename: Mehdi
authors.initials: M
authors.lastname: Jalili
authors.forename: J Pablo
authors.initials: JP
authors.lastname: Villablanca
authors.forename: J Paul
authors.initials: JP
authors.lastname: Finn
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020757:Amaurosis Fugax / Q000175:diagnosis; D001157:Arterial Occlusive Diseases / Q000175:diagnosis; D002340:Carotid Artery Diseases / Q000175:diagnosis*; D003287:Contrast Media / Q000008:administration & dosage*; D005240:Feasibility Studies; D005260:Female; D005352:Fibromuscular Dysplasia / Q000175:diagnosis; D006261:Headache / Q000175:diagnosis; D006801:Humans; D002532:Intracranial Aneurysm / Q000175:diagnosis; D002546:Ischemic Attack, Transient / Q000175:diagnosis; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009072:Moyamoya Disease / Q000175:diagnosis; D020521:Stroke / Q000175:diagnosis; D014715:Vertebrobasilar Insufficiency / Q000175:diagnosis*; D014717:Vertigo / Q000175:diagnosis
chemical_list: D003287:Contrast Media