A portable surface-enhanced Raman scattering sensor integrated with a lab-on-a-chip for field analysis.
An integrated real-time sensing system that uses a portable Raman spectrometer and a micropillar array chip has been developed for field analysis. The problem of poor detection sensitivity, caused by miniaturization in the portable Raman spectrometer, was overcome by using the surface-enhanced Raman scattering (SERS) technique. The problem of poor reproducibility in the SERS detection, caused by different particle sizes and inhomogeneous degrees of aggregation, was also overcome by using continuous flow and homogeneous mixing between the analytes and nanocolloidal silver in a micropillar array microfluidic chip. Two hazardous materials, dipicolinic acid and malachite green, were quantitatively analysed using our integrated portable Raman sensor system. The observed limit of detection was estimated to be 200 ppb and 500 ppb, respectively. Our proposed analytical method, using a micropillar array PDMS chip and a portable SERS system, offers a rapid and reproducible trace detection capability for hazardous materials in the field.
Quang
Ly Xuan
LX
Department of Applied Chemistry, Hanyang University, Ansan, 426-791, South Korea.
Lim
Chaesung
C
Seong
Gi Hun
GH
Choo
Jaebum
J
Do
Ki Jun
KJ
Yoo
Seoung-Kyo
SK
D005659:Fungicides, Industrial / Q000737:chemistry*; D044085:Microfluidics / Q000295:instrumentation* / Q000379:methods; D010848:Picolinic Acids / Q000737:chemistry*; D012394:Rosaniline Dyes / Q000737:chemistry*; D013059:Spectrum Analysis, Raman / Q000295:instrumentation / Q000379:methods
D005659:Fungicides, Industrial; D010848:Picolinic Acids; D012394:Rosaniline Dyes; C005095:malachite green; C004860:dipicolinic acid