Correlations of six related purine metabolites and diabetic nephropathy in Chinese type 2 diabetic patients.
OBJECTIVE
The assessment of the clinical significance of adenosine, adenine, inosine, xanthine, hypoxanthine and uric acid concentrations in patients with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN) for the detection of the relationship between purine metabolites and disease.


METHODS
The study group consisted of 119 subjects which were divided into three groups: control (n=31), type 2 diabetes without nephropathy (DM, n=23) and with nephropathy (DN, n=65). Levels of related metabolites were measured in plasma of all participants.


RESULTS
There is a significant increase of levels of adenosine (P<0.001), inosine (P<0.001), xanthine (P=0.012) and uric acid (P=0.016) with DN compared to DM. The level of xanthine oxidase (reflected by the uric acid: xanthine) did not change.


CONCLUSIONS
The levels of adenosine, inosine, uric acid and xanthine may be useful for monitoring the progression of DM and evaluating the treatment.
Xia
Jian-Fei
JF
School of Pharmaceutics, East-China University of Science and Technology, China.
Liang
Qiong-Lin
QL
Hu
Ping
P
Wang
Yi-Ming
YM
Li
Ping
P
Luo
Guo-An
GA
D000241:Adenosine / Q000097:blood; D000368:Aged; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000378:metabolism; D003928:Diabetic Nephropathies / Q000097:blood* / Q000378:metabolism; D005260:Female; D006801:Humans; D007288:Inosine / Q000097:blood; D008297:Male; D008875:Middle Aged; D011687:Purines / Q000097:blood* / Q000378:metabolism; D014527:Uric Acid / Q000097:blood; D019820:Xanthine / Q000097:blood
D015415:Biomarkers; D011687:Purines; D019820:Xanthine; D014527:Uric Acid; D007288:Inosine; D000241:Adenosine