Morphogenesis and biological significance of spindle cell transformation in a spindle cell carcinoma.
Our study investigated the histogenesis and biological significance of spindle cell carcinoma (SpCC) by comparing with moderately-well-differentiated squamous cell carcinoma (SCC) cell lines. Snail mRNA expression was readily detectable in the SpCC cell line, while E-cadherin was undetectable. SpCC cells showed lower proliferative and invasive activities than two other SCC cell lines. Culturing under air-liquid interface conditions promoted squamous cell differentiation, whereas fibroblastic differentiation after submerged culture with collagen, suggesting that the microenvironment may be a regulating factor of spindle cell differentiation as well as Snail expression and spindle cell change may not always entail the invasive behavior.
Kim
Eun Jung
EJ
Oral Cancer Research Institute, Department of Oral Pathology, Brain Korea 21 Project, Yonsei University, College of Dentistry, 134 Shinchon-dong, Seodaemun-Gu, Seoul 120-749, Republic of Korea.
Che
Zhong Min
ZM
Park
Young Jin
YJ
Hwang
Young Sun
YS
Kim
Ki Yeol
KY
Jung
Da Woon
DW
Jeon
Nam Kyung
NK
Choi
Young Wook
YW
Lee
Eun Ju
EJ
Kim
Jin
J
D000328:Adult; D000818:Animals; D015820:Cadherins / Q000378:metabolism; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology*; D002454:Cell Differentiation; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic; D004848:Epithelium / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D008297:Male; D008648:Mesoderm / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors / Q000378:metabolism
D015820:Cadherins; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors