Flavonoids: prospective drug candidates.
The purpose of this review is to discuss the recent developments related to the chemistry and medicinal properties of flavonoids. Major flavonoids that show well categorized structures and well defined structure function-relationships are: flavans, flavanones, flavones, flavanonols, flavonols, catechins, anthocyanidins and isoflavone. The biological properties of flavonoids include antioxidant, anti-inflamatory, antitumoral, antiviral and antibacterial, as well as a direct cytoprotective effect on coronary and vascular systems, the pancreas and the liver. These characteristics place them among the most attractive natural substances available to enrich the current therapy options.
Cazarolli
Luisa Helena
LH
Departamento de Bioquímica, Centro de Ciências Biológicas, Campus Universitário, UFSC, Bairro Trindade, Cx. Postal 5069, CEP: 88040-970, Florianópolis, SC, Brazil.
Zanatta
Leila
L
Alberton
Elga Heloisa
EH
Figueiredo
Maria Santos Reis Bonorino
MS
Folador
Poliane
P
Damazio
Rosangela Guollo
RG
Pizzolatti
Moacir Geraldo
MG
Silva
Fátima Regina Mena Barreto
FR
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000975:Antioxidants / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D005419:Flavonoids / Q000737:chemistry / Q000145:classification / Q000493:pharmacokinetics* / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D007408:Intestinal Absorption
D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D000998:Antiviral Agents; D005419:Flavonoids