Age-related decrease in constructive activation of Akt/PKB in SAMP10 hippocampus.
Aging is the greatest risk factor for neurodegenerative diseases such as Alzheimer's disease (AD). Age-dependent alterations of cell signaling play an important role in the onset of AD. The serine/threonine kinase Akt is a critical cell signaling to neuronal survival. Using the senescence-accelerated mouse SAMP10, we investigated the effect of aging on AKT signaling in hippocampus tissue. During aging, the expression of Akt mRNA and protein remained stable. However, the constructive phosphorylation of Akt(Ser473) displayed a continuous decrease after 6 months in SAMP10. When compared with the control SAMR1, aged SAMP10 mice showed significant reduced phosphorylation of Akt(Ser473). SAMP10 at the age of 6 months showed obvious deterioration in performance of learning and memory tasks. Thus, the data reported here suggested a potential link between the age-related alteration of Akt(Ser473) and the deterioration in performance of learning and memory tasks in SAMP10 mouse.
Nie
Kun
K
Tianjin Key Laboratory of Acupuncture and Moxibustion, Acupuncture and Moxibustion Research Institute, The First Hospital affiliated to Tianjin College of Traditional Chinese Medicine, 314 West Anshan Avenue, Tianjin 300193, PR China.
Yu
Jian-Chun
JC
Fu
Yu
Y
Cheng
Hai-Yan
HY
Chen
Fu-Yan
FY
Qu
You
Y
Han
Jing-Xian
JX
D000367:Age Factors; D000375:Aging / Q000378:metabolism*; D019588:Aging, Premature / Q000201:enzymology*; D000544:Alzheimer Disease / Q000201:enzymology* / Q000503:physiopathology; D000818:Animals; D006624:Hippocampus / Q000201:enzymology* / Q000503:physiopathology; D008297:Male; D018782:Maze Learning; D008568:Memory; D051379:Mice; D008817:Mice, Mutant Strains; D010766:Phosphorylation; D051057:Proto-Oncogene Proteins c-akt / Q000096:biosynthesis* / Q000235:genetics; D012694:Serine / Q000378:metabolism; D015398:Signal Transduction
D012694:Serine; D051057:Proto-Oncogene Proteins c-akt