Comparison of detailed and succinct cohort modelling approaches in a multi-regional evaluation of cervical cancer vaccination.
Mathematical models have been used extensively in the evaluation of chronic diseases and in exploring the health economics of vaccination. In this study, we examine the value of having two different cohort models based on similar assumptions, one comprehensive and one simplified, which can be used to evaluate the impact of cervical cancer vaccination. To compare models, we ran cost-effectiveness analyses in four geographical regions (Italy, the UK, Taiwan and Canada). We show that the models produce comparable results and therefore can be used independently. However, as they require different complexities of data inputs, they are more suited to different circumstances depending on the level of data inputs available or the complexity of the research question asked.
Debicki
Donna
D
Health Economics and Outcomes Research, i3 Innovus, 1016-A Sutton Drive, Burlington, Ontario, Canada. Donna.DEBICKI@i3innovus.com
Ferko
Nicole
N
Demarteau
Nadia
N
Gallivan
Steve
S
Bauch
Chris
C
Anonychuk
Andrea
A
Mantovani
Lorenzo
L
Capri
Stefano
S
Chou
Cheng-Yang
CY
Standaert
Baudouin
B
Annemans
Lieven
L
D003365:Costs and Cost Analysis / Q000379:methods; D005260:Female; D006801:Humans; D017059:Models, Econometric; D002583:Uterine Cervical Neoplasms / Q000191:economics* / Q000517:prevention & control*; D014611:Vaccination / Q000191:economics*