Nedd4L expression is downregulated in prostate cancer compared to benign prostatic hyperplasia.
OBJECTIVE
To characterize aspects of Nedd4L in prostate cancer (PC) by assessing its expression in hyperplastic and malignant prostate tissue, and to correlate findings with PC histologic grade.


METHODS
Radical prostatectomy (RP) specimens from 56 patients with clinically localized PC, and benign prostatic hyperplasia (BPH) transurethral resection specimens from 31 patients, were assessed for Nedd4L expression using immunohistochemistry.


RESULTS
Nedd4L (P<0.001) expressions were significantly decreased in PC compared to benign prostate tissue. Furthermore, downregulation of Nedd4L (P<0.05) expression correlated with increasing Gleason score.


CONCLUSIONS
These data suggest that prostate cancer cells in vivo may need Nedd4L expression to regulate TGF-beta1 signaling, and that Nedd4L expression might be involved in prostate cancer development.
Hu
X Y
XY
Department of Urology, Shanghai Jiaotong University Affiliated 6th People's Hospital, Shanghai Jiaotong University, Shanghai, PR China.
Xu
Y M
YM
Fu
Q
Q
Yu
J J
JJ
Huang
J
J
D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D016009:Chi-Square Distribution; D015536:Down-Regulation; D056827:Endosomal Sorting Complexes Required for Transport; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D000075702:Nedd4 Ubiquitin Protein Ligases; D011468:Prostatectomy; D011470:Prostatic Hyperplasia / Q000378:metabolism* / Q000601:surgery; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000601:surgery; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*
D014408:Biomarkers, Tumor; D056827:Endosomal Sorting Complexes Required for Transport; D000075702:Nedd4 Ubiquitin Protein Ligases; C000618485:Nedd4L protein, human; D044767:Ubiquitin-Protein Ligases