[Genetic aspects of longevity and aging].
To clarify the role of genetic factors in aging and longevity some clinical and genealogical characteristics of different age groups (54 patients of both sexes) were studied; 34 of them were long livers (>90y) and 20 - the elderly (70-90y). Clinical and laboratory investigations were provided according to WHO experts recommendations. Total content of Cholesterol and Triglycerides was assessed by the enzyme-measuring method. Based on the genealogical questionnaire methods, the data concerning morbidity, mortality, health status and CVD were collected about 206 people (in total) including the parents and siblings of the patients. The long-livers' fathers were found to live longer than the fathers of the elderly that confirms the idea of paternal-line inheritance of life longevity. The male longlivers' fathers live 10 years longer, than female longlivers' fathers (P<0,05). Maternal line doesn't influence on the longevity. We also noticed genealogical relation between health status of longlivers (absence of cardiovascular diseases) and genealogical anamnesis of their parents. The stability of lipid metabolism was observed in longlivers and the elderly that was confirmed by the low amount of total Cholesterol being lower in the longlivers. In both groups the correlation between the total Cholesterol content and the percentage of CVD cases was observed. Proceeding from the above, we can confirm the important role of genetic factors to reach the long age.
Kakauridze
N
N
National Center of Therapy, Tbilisi.
Guchua
E
E
Mgebrishvili
M
M
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics*; D008078:Cholesterol, LDL / Q000378:metabolism; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D005846:Georgia (Republic) / Q000453:epidemiology; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008297:Male
D008078:Cholesterol, LDL