title: [Cognitive disturbances in the progression of Parkinson's disease].
abstract: Cognitive impairment (CD) have been studied in 88 patients with progressive Parkinson's disease (PD). It has been shown that CD in PD have a progressive character mostly due the increase of intensity of dysregulation and neurodynamic disorders, disturbances of visual-spatial functions and, in some cases, insufficiency of nominative speech function. A 2-5 years follow-up revealed the high frequency of transformation of moderate cognitive dysfunction into dementia. The old age of patients at baseline, late-onset and severity of disease were identified as predictors of CD progression in PD. The highest rate of CD progression was observed in patients with more pronounced premorbid disturbances of regulative and visual-spatial functions.
authors.forename: D A
authors.initials: DA
authors.lastname: Stepkina
authors.forename: V V
authors.initials: VV
authors.lastname: Zakharov
authors.forename: N N
authors.initials: NN
authors.lastname: Iakhno
mesh_terms: D000328:Adult; D000368:Aged; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000209:etiology* / Q000503:physiopathology; D003073:Cognitive Dissonance; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000503:physiopathology; D011379:Prognosis; D013997:Time Factors