title: Synthesis of condensed pyrroloindoles via Pd-catalyzed intramolecular C-H bond functionalization of pyrroles.
abstract: A new strategy for the synthesis of condensed hetero- or carbocycles such as pyrroloindoles or fluorenes has been developed that involves the Pd-catalyzed cyclization of readily available N-(2-halobenzyl)pyrroles or their phenyl derivatives. The reaction is proposed to proceed via oxidative addition of benzylic halides to Pd(0) followed by base-assisted C-H bond activation. A broad range of condensed cyclic products could be obtained in good to excellent yields under mild conditions.
authors.affiliation: Department of Chemistry and School of Molecular Science (BK21), Korea Advanced Institute of Science and Technology, Daejeon 305-701 Republic of Korea.
authors.forename: Seung Jun
authors.initials: SJ
authors.lastname: Hwang
authors.forename: Seung Hwan
authors.initials: SH
authors.lastname: Cho
authors.forename: Sukbok
authors.initials: S
authors.lastname: Chang
mesh_terms: D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006859:Hydrogen / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*
chemical_list: D007211:Indoles; D011758:Pyrroles; D010165:Palladium; D002244:Carbon; D006859:Hydrogen