Adoptive precursor cell therapy to enhance immune reconstitution after hematopoietic stem cell transplantation in mouse and man.
Hematopoietic stem cell transplantation is a curative therapy for hematological malignancies. T cell deficiency following transplantation is a major cause of morbidity and mortality. In this review, we discuss adoptive transfer of committed precursor cells to enhance T cell reconstitution and improve overall prognosis after transplantation.
Holland
Amanda M
AM
Department of Immunology, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA.
Zakrzewski
Johannes L
JL
Goldberg
Gabrielle L
GL
Ghosh
Arnab
A
van den Brink
Marcel R M
MR
D000818:Animals; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods*; D051379:Mice; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*