Persistent normalization of serum levels of uric acid in a gouty patient after administration of cyproterone acetate.
In this article we describe a gouty caucasian male patient who had high levels of serum uric acid since 1970s. Serious adverse reactions to allopurinol discouraged its administration. We prescribed cyproterone acetate (CA) because of severe prostatic hypertrophy, associated with a suspect small cancer. The administration of this drug obtained persistent normalization of serum uric acid levels. Our observation, that needs to be confirmed in other cases, could suggest a possible new treatment for gout in male patients with prostatic disorders.
Palazzi
C
C
Division of Rheumatology, Villa Pini Clinic, Chieti, Italy. palazzi.carlo@tiscali.it
D'Angelo
S
S
Pennese
E
E
Olivieri
I
I
D000369:Aged, 80 and over; D000726:Androgen Antagonists / Q000008:administration & dosage*; D017373:Cyproterone Acetate / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D006073:Gout / Q000188:drug therapy*; D006801:Humans; D008297:Male; D011469:Prostatic Diseases / Q000150:complications*; D013997:Time Factors; D016896:Treatment Outcome; D014527:Uric Acid / Q000097:blood*
D000726:Androgen Antagonists; D014527:Uric Acid; D017373:Cyproterone Acetate