title: Quantitative EEG findings in patients with acute, brief depression combined with other fluctuating psychiatric symptoms: a controlled study from an acute psychiatric department.
abstract: BACKGROUND
  Patients with brief depressive episodes and concurrent rapidly fluctuating psychiatric symptoms do not fit current diagnostic criteria and they can be difficult to diagnose and treat in an acute psychiatric setting. We wanted to study whether these patients had signs of more epileptic or organic brain dysfunction than patients with depression without additional symptomatology.
  
  
  METHODS
  Sixteen acutely admitted patients diagnosed with a brief depressive episode as well as another concurrent psychiatric diagnosis were included. Sixteen patients with major depression served as controls. Three electroencephalographic studies (EEG) were visually interpreted and the background activity was also analysed with quantitative electroencephalography (QEEG).
  
  
  RESULTS
  The group with brief depression and concurrent symptoms had multiple abnormal features in their standard EEG compared to patients with major depression, but they did not show significantly more epileptiform activity. They also had significantly higher temporal QEEG delta amplitude and interhemispheric temporal delta asymmetry.
  
  
  CONCLUSIONS
  Organic brain dysfunction may be involved in the pathogenesis of patients with brief depressive episodes mixed with rapidly fluctuating psychiatric symptoms. This subgroup of depressed patients should be investigated further in order to clarify the pathophysiology and to establish the optimal evaluation scheme and treatment in an acute psychiatric setting.
authors.affiliation: Department of Neurology and Clinical Neurophysiology, St Olavs Hospital, Trondheim, Norway. marte.bjork@ntnu.no
authors.forename: Marte Helene
authors.initials: MH
authors.lastname: Bjørk
authors.forename: Trond
authors.initials: T
authors.lastname: Sand
authors.forename: Geir
authors.initials: G
authors.lastname: Bråthen
authors.forename: Olav M
authors.initials: OM
authors.lastname: Linaker
authors.forename: Gunnar
authors.initials: G
authors.lastname: Morken
authors.forename: Brigt M
authors.initials: BM
authors.lastname: Nilsen
authors.forename: Arne Einar
authors.initials: AE
authors.lastname: Vaaler
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000453:epidemiology; D000513:Alpha Rhythm; D000927:Anticonvulsants / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000627:therapeutic use; D002648:Child; D003700:Delta Rhythm; D003863:Depression / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology*; D003937:Diagnosis, Differential; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004569:Electroencephalography; D004827:Epilepsy / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008875:Middle Aged; D009664:Norway; D011567:Psychiatric Department, Hospital; D011618:Psychotic Disorders / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology; D055815:Young Adult
chemical_list: D000927:Anticonvulsants; D014150:Antipsychotic Agents