title: Potential role of lycopene in the treatment of hepatitis C and prevention of hepatocellular carcinoma.
abstract: Hepatitis C virus (HCV) infection and hepatocellular carcinoma (HCC) are growing health problems around the world. Oxidative stress plays a significant role in the initiation and progression of hepatocellular damage and possibly in the development of HCC in HCV infected patients. In vitro, animal and clinical studies suggest that lycopene, a nonprovitamin A carotenoid and a potent antioxidant, may attenuate the liver injury and possibly prevent the development of HCC. In this article, we discuss the relationship between HCV infection and oxidative stress and review the potential role of lycopene in the treatment of HCV and prevention of HCC.
authors.affiliation: Department of Medicine, Wayne State University, Detroit, MI, USA.
authors.forename: Soley
authors.initials: S
authors.lastname: Seren
authors.forename: Milton
authors.initials: M
authors.lastname: Mutchnick
authors.forename: Daryl
authors.initials: D
authors.lastname: Hutchinson
authors.forename: Ozgur
authors.initials: O
authors.lastname: Harmanci
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Bayraktar
authors.forename: Sean
authors.initials: S
authors.lastname: Mutchnick
authors.forename: Kazim
authors.initials: K
authors.lastname: Sahin
authors.forename: Omer
authors.initials: O
authors.lastname: Kucuk
mesh_terms: D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000517:prevention & control*; D002338:Carotenoids / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D008103:Liver Cirrhosis / Q000378:metabolism; D008113:Liver Neoplasms / Q000378:metabolism / Q000517:prevention & control*; D000077276:Lycopene; D018384:Oxidative Stress
chemical_list: D016588:Anticarcinogenic Agents; D000975:Antioxidants; D002338:Carotenoids; D000077276:Lycopene