title: Metabolic syndrome after risk-reducing salpingo-oophorectomy in women at high risk for hereditary breast ovarian cancer: a controlled observational study.
abstract: Surgical menopause may increase the risk of cardiovascular diseases (CVDs). The aim of this study was to determine the risk of metabolic syndrome in women who had undergone risk-reducing salpingo-oophorectomy (RRSO) because of increased risk of hereditary breast ovarian cancer (HBOC). A sample of 326 (65% of invited) women at risk of HBOC who had undergone RRSO was compared to 679 women from the general population. Mean follow-up after surgery was 6.5 years (standard deviations [SD] 4.4). RRSO was significantly associated with metabolic syndrome according to the 2005 National Cholesterol Education Program Adult Treatment Panel III criteria (odds ratio [OR] 2.46 [95% confidence interval (CI) 1.63, 3.73]) and according to the International Diabetes Federation criteria (OR 2.49 [CI 1.60, 3.88]), as were increasing age and body mass index (BMI). RRSO in women at risk of HBOC is significantly associated with the metabolic syndrome, and the follow-up after RRSO should take these findings into consideration.
authors.affiliation: Department of Gynaecology, Sørlandet Hospital Arendal, Arendal, Norway. trond.melbye.michelsen@sshf.no
authors.forename: Trond M
authors.initials: TM
authors.lastname: Michelsen
authors.forename: Are H
authors.initials: AH
authors.lastname: Pripp
authors.forename: Serena
authors.initials: S
authors.lastname: Tonstad
authors.forename: Claes G
authors.initials: CG
authors.lastname: Tropé
authors.forename: Anne
authors.initials: A
authors.lastname: Dørum
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001943:Breast Neoplasms / Q000097:blood / Q000235:genetics / Q000601:surgery; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D005187:Fallopian Tubes / Q000601:surgery; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D024821:Metabolic Syndrome / Q000097:blood / Q000209:etiology*; D008875:Middle Aged; D009664:Norway; D010051:Ovarian Neoplasms / Q000097:blood / Q000235:genetics / Q000601:surgery; D010052:Ovariectomy; D011184:Postoperative Period; D012306:Risk; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D014280:Triglycerides