title: Ovarian stimulation for fertility preservation in patients with cancer.
abstract: OBJECTIVE
  To evaluate controlled ovarian hyperstimulation (COH) in women with cancer compared with healthy women.
  
  
  METHODS
  A retrospective cohort study.
  
  
  METHODS
  Academic assisted reproductive technology (ART) program.
  
  
  METHODS
  Fifty women undergoing oocyte retrieval before cancer treatment and 50 age-matched controls.
  
  
  METHODS
  None.
  
  
  METHODS
  Number of oocytes and matured oocytes retrieved, number of fertilized oocytes, days of stimulation, dose of gonadotropins.
  
  
  RESULTS
  There were no significant differences in the number of oocytes retrieved (13 vs. 11.5), the number of matured oocytes retrieved (9.7 vs. 9.6), and the number of oocytes fertilized (7.4 vs. 6.8). However, the patients with cancer had a longer duration of stimulation (10.5 vs. 9.0 days) and higher total dose of gonadotropins (4,174 IU vs. 3,416 IU).
  
  
  CONCLUSIONS
  In our study, reasonable ovarian response was achieved by women with cancer with increased doses of gonadotropins and a longer duration of stimulation.
authors.affiliation: Department of Obstetrics & Gynecology, Division of Reproductive Endocrinology & Infertility, Stanford University, Stanford, California 94304, USA.
authors.forename: Rudolpho B
authors.initials: RB
authors.lastname: Quintero
authors.forename: Amy
authors.initials: A
authors.lastname: Helmer
authors.forename: Jian Qun
authors.initials: JQ
authors.lastname: Huang
authors.forename: Lynn M
authors.initials: LM
authors.lastname: Westphal
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects; D001943:Breast Neoplasms / Q000150:complications* / Q000188:drug therapy; D002452:Cell Count; D005260:Female; D005298:Fertility; D006801:Humans; D007247:Infertility, Female / Q000209:etiology* / Q000628:therapy*; D054315:Oocyte Retrieval / Q000379:methods*; D009865:Oocytes / Q000166:cytology; D010062:Ovulation Induction / Q000379:methods*; D027724:Reproductive Techniques, Assisted; D012189:Retrospective Studies
chemical_list: D000970:Antineoplastic Agents