title: Patient dosimetry for total body irradiation using single-use MOSFET detectors.
abstract: We studied the usefulness of a new type of solid-state detector, the OneDose single-use MOSFET (metal oxide semiconductor field effect transistor) dosimeter, for entrance dose measurements for total body irradiation (TBI). The factory calibration factors supplied by the manufacturer are applicable to conventional radiotherapy beam arrangements and therefore may not be expected to be valid for TBI dosimetry because of the large field sizes and extended source-to-axis distances used. OneDose detectors were placed under a 1-cm thick bolus at the head, neck, and umbilicus of 9 patients undergoing TBI procedures. Thermoluminescent dosimeters (TLDs) were placed beside the detectors. We found that the OneDose readings differed from the TLD readings by 4.6% at the head, 1.7% at the neck, and 3.9% at the umbilicus, with corresponding standard deviations of 3.9%, 2.2%, and 2.7%. For all patient measurements, 95% of the OneDose readings fell within 3.3% +/- 6.0% of the TLD readings. Anthropomorphic phantom measurements showed differences of -0.1% at the neck and -1.2% midway between the phantom's carina and umbilicus. Our results suggest that these detectors could be used for TBI quality assurance monitoring, although TLDs should remain the standard when critical dose measurements are performed. If OneDose detectors are to be used for TBI, the use of more than one at each location is strongly recommended. Because the detectors are designed for single use, they cannot be individually calibrated. However, to obtain institution-specific correction factors for better applicability to TBI dosimetry, measurements of several detectors taken from a particular lot could also be obtained in phantom with the TBI geometry configurations used for patient treatment.
authors.affiliation: Department of Radiation Physics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, U.S.A.
authors.forename: Tina Marie
authors.initials: TM
authors.lastname: Briere
authors.affiliation: Department of Radiation Physics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, U.S.A.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Tailor
authors.affiliation: Department of Radiation Physics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, U.S.A.
authors.forename: Naresh
authors.initials: N
authors.lastname: Tolani
authors.affiliation: Department of Radiation Physics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, U.S.A.
authors.forename: Karl
authors.initials: K
authors.lastname: Prado
authors.affiliation: Department of Radiation Physics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, U.S.A.
authors.forename: Richard
authors.initials: R
authors.lastname: Lane
authors.affiliation: Division of Radiation Oncology, and Division of Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, U.S.A.
authors.forename: Shiao
authors.initials: S
authors.lastname: Woo
authors.affiliation: Division of Radiation Oncology, and Division of Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, U.S.A.
authors.forename: Chul
authors.initials: C
authors.lastname: Ha
authors.affiliation: Department of Radiation Physics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, U.S.A.
authors.forename: Michael T
authors.initials: MT
authors.lastname: Gillin
authors.affiliation: Department of Radiation Physics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, U.S.A.
authors.forename: A Sam
authors.initials: AS
authors.lastname: Beddar
mesh_terms: D002138:Calibration; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D010087:Oxides / Q000737:chemistry; D019047:Phantoms, Imaging; D017785:Photons; D011874:Radiometry / Q000295:instrumentation* / Q000379:methods*; D011880:Radiotherapy Planning, Computer-Assisted / Q000295:instrumentation; D015203:Reproducibility of Results; D012666:Semiconductors; D012825:Silicon; D013819:Thermoluminescent Dosimetry / Q000295:instrumentation* / Q000379:methods*; D014916:Whole-Body Irradiation / Q000295:instrumentation / Q000379:methods*
chemical_list: D010087:Oxides; D012825:Silicon