title: Influence of cardiovascular autonomic neuropathy on atherogenesis and heart function in patients with type 1 diabetes.
abstract: OBJECTIVE
  Cardiovascular autonomic neuropathy (CAN) increases mortality of patients with type 1 diabetes (Type 1 DM). We set out to find out whether the presence of CAN in asymptomatic, normotensive Type 1 DM affects endothelial function (marker of atherogenesis) and left ventricle function (marker of cardiomyopathy).
  
  
  METHODS
  Twenty-one Type 1 DM with CAN (Group A) and 35 Type 1 DM without CAN (Group B) were enrolled in the study. None of them suffered from any cardiovascular disease nor advanced chronic complications of diabetes. Both groups were comparable in age, glycemic control, BMI, and blood pressure. Markers of endothelial dysfunction and chronic inflammation were used as indicators of incipient atherogenesis. Left ventricle function was evaluated using echocardiography.
  
  
  RESULTS
  Both groups did not differ in any parameter of atherogenesis. However we found a statistically significant difference in values characterizing systolic and diastolic left ventricle functions between the groups.
  
  
  CONCLUSIONS
  CAN is not associated with elevation of markers of endothelial dysfunction and chronic inflammation in normotensive asymptomatic Type 1 DM. However CAN is associated with the impairment of systolic and diastolic left ventricle function and can thus be regarded as one of the risk factors of diabetic cardiomyopathy.
authors.affiliation: Department of Diabetology, University Hospital, Charles University in Prague, Faculty of Medicine in Pilsen, Czech Republic. lacigova@fnplzen.cz
authors.forename: Silvie
authors.initials: S
authors.lastname: Lacigova
authors.forename: Lubos
authors.initials: L
authors.lastname: Bartunek
authors.forename: Daniela
authors.initials: D
authors.lastname: Cechurova
authors.forename: Jakub
authors.initials: J
authors.lastname: Visek
authors.forename: Jitka
authors.initials: J
authors.lastname: Gruberova
authors.forename: Michal
authors.initials: M
authors.lastname: Krcma
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Jankovec
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Rusavy
authors.forename: Michal
authors.initials: M
authors.lastname: Zourek
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000209:etiology / Q000503:physiopathology*; D001342:Autonomic Nervous System Diseases / Q000503:physiopathology*; D009202:Cardiomyopathies / Q000503:physiopathology*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000503:physiopathology*; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018487:Ventricular Dysfunction, Left / Q000209:etiology / Q000503:physiopathology*