Is there an association between uterine leiomyomas and acid phosphatase locus 1 polymorphism?
OBJECTIVE
Platelet derived growth factor (PDGF) is involved in the development of leiomyomas. The low-molecular-weight phosphoprotein-tyrosine-phosphatase (LMWPTP), controlled by the highly polymorphic acid phosphatase locus 1 (ACP1), is able to dephosphorylate the PDGF receptor. Therefore, we searched for a possible association between ACP1 and leiomyomas.


METHODS
We studied 172 women hospitalized for symptomatic leiomyomas requiring surgical intervention and 164 healthy women without clinical evidence of leiomyomas from the same white population. The chi(2) test of independence, Pearson correlation, analysis of variance, and post hoc test for difference between means were performed.


RESULTS
The distribution of ACP1 genotypes among patients does not differ significantly from that of healthy women. However, leiomyoma size was negatively correlated with ACP1 F isoform concentrations. Leiomyoma size was smaller among carriers of the *B/*B genotype, which has the highest concentration of the F isoform, than among carriers of *A/*A, *C/*B, and *C/*C genotypes, which have the lowest concentration of the F isoform.


CONCLUSIONS
High ACP1 F isoform concentration, through dephosphorylation of the PDGF receptor, may negatively regulate cell proliferation and growth of leiomyomas.
Ammendola
Maria Laura
ML
Department of Surgery, University of Rome Tor Vergata School of Medicine, Rome, Italy.
Pietropolli
Adalgisa
A
Lista
Florigio
F
Saccucci
Patrizia
P
Piccione
Emilio
E
Bottini
Egidio
E
Gloria-Bottini
Fulvia
F
D000328:Adult; D004247:DNA / Q000737:chemistry / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D007889:Leiomyoma / Q000201:enzymology* / Q000235:genetics; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D020033:Protein Isoforms; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D018709:Statistics, Nonparametric; D014594:Uterine Neoplasms / Q000201:enzymology* / Q000235:genetics
D020033:Protein Isoforms; D011518:Proto-Oncogene Proteins; D004247:DNA; C490429:ACP1 protein, human; D017027:Protein Tyrosine Phosphatases