title: Consensus statement on the revised World Health Organization recommendations for BCG vaccination in HIV-infected infants.
abstract: This document outlines the consensus agreement from the Union's BCG Working Group regarding BCG vaccination in HIV-infected infants, in response to recently revised World Health Organization (WHO) guidelines, which make HIV infection in infants a full contraindication to bacille Calmette-Guérin (BCG) vaccination. BCG is one of the most widely given vaccines globally and is safe in immunocompetent individuals. Recent evidence shows that HIV-infected infants who were routinely vaccinated with BCG at birth, when asymptomatic, and who later developed AIDS, are at high risk of developing disseminated BCG disease (estimated incidence 407-1300 per 100 000). The document outlines requirements to implement selective BCG vaccination strategies in infants born to HIV-infected women and strategies to reduce the risk of vertical HIV transmission and disseminated BCG disease in infants.
authors.affiliation: Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Tygerberg, South Africa. annekeh@sun.ac.za
authors.forename: A C
authors.initials: AC
authors.lastname: Hesseling
authors.forename: M F
authors.initials: MF
authors.lastname: Cotton
authors.forename: C
authors.initials: C
authors.lastname: Fordham von Reyn
authors.forename: S M
authors.initials: SM
authors.lastname: Graham
authors.forename: R P
authors.initials: RP
authors.lastname: Gie
authors.forename: G D
authors.initials: GD
authors.lastname: Hussey
mesh_terms: D001500:BCG Vaccine / Q000008:administration & dosage* / Q000009:adverse effects; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D014611:Vaccination / Q000592:standards; D014944:World Health Organization
chemical_list: D001500:BCG Vaccine