title: [Treatment of spontaneous intracranial hypotension by epidural saline infusion].
abstract: BACKGROUND
  Spontaneous intracranial hypotension (SIH) is an uncommon cause of secondary headache due to a cerebrospinal fluid (CSF) hypotension. Lumbar epidural blood-patch (LEBP) is the most effective treatment and can be repeated in case of relapse. There is no standard therapeutic strategy for patients free of dural tears who fail to respond to several consecutive blood-patches. We report two cases of SIH successfully treated by an epidural saline infusion after two consecutive LEBP.
  
  
  METHODS
  A 35-year-old woman was admitted to hospital for severe orthostatic headache. The diagnosis of SIH was retained. Two LEBP were performed but with no clinical benefit. Headache disappeared totally after an epidural saline infusion. A second woman, aged 75 years, was admitted for chronic orthostatic headaches. The CSF pressure was low. Search for a dural tear was negative. After two unsuccessful LEBPs, the patient was treated with an epidural saline infusion. Her headache resolved completely and definitely.
  
  
  CONCLUSIONS
  It is common procedure to search for a dural tear when patients fail to respond to several consecutive LEPB. Surgical repair is however exceptional. An epidural saline infusion might be an efficient therapeutic alternative despite the small number of cases reported in the literature.
authors.affiliation: Service de neurologie, hôpital Yves-le-Foll, Saint-Brieuc, France. tiphainerouaud@yahoo.fr
authors.forename: T
authors.initials: T
authors.lastname: Rouaud
authors.forename: F
authors.initials: F
authors.lastname: Lallement
authors.forename: R
authors.initials: R
authors.lastname: Choui
authors.forename: M
authors.initials: M
authors.lastname: Madigand
mesh_terms: D000328:Adult; D000368:Aged; D002555:Cerebrospinal Fluid / Q000502:physiology; D005260:Female; D006261:Headache / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D006801:Humans; D007262:Infusions, Intravenous; D019585:Intracranial Hypotension / Q000188:drug therapy* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D012965:Sodium Chloride / Q000008:administration & dosage* / Q000627:therapeutic use*
chemical_list: D012965:Sodium Chloride