title: Evaluating sub-clinical cognitive dysfunction and event-related potentials (P300) in clinically isolated syndrome.
abstract: OBJECTIVE
  This study investigated the presence of sub-clinical cognitive dysfunction in patients with clinically isolated syndrome (CIS) and the abnormalities of cognitive event-related potentials (ERPs).
  
  
  METHODS
  Subclinical cognitive dysfunction was assessed in 20 patients with CIS and in 20 healthy controls.
  
  
  RESULTS
  Patients had impairments in verbal learning and long-term memory, evaluating attention, executive function and visuospatial skills, in decreasing order of frequency. SDLT and SIT were the most, and COWAT and BNT were the least affected tests. The N200 and P200 latencies were prolonged, and N100, N200 and P200 amplitudes were reduced in the patients relative to the controls, from the Fz, Cz and Pz electrode positions (p<0.05).
  
  
  CONCLUSIONS
  Detailed cognitive testing is valuable in determining subclinical cognitive dysfunction in CIS patients. ERP abnormalities as well as abnormalities in detailed cognitivetesting in patients with CIS are helpful in the diagnosis of sub-clinical cognitive dysfunction.
authors.affiliation: Department of Neurology, Gazi University Medical Faculty, Nöroloji Anabilim Dali, Beşevler, Cankaya, Turkey. ebkocer@yahoo.com
authors.forename: Belgin
authors.initials: B
authors.lastname: Kocer
authors.forename: Tugba
authors.initials: T
authors.lastname: Unal
authors.forename: Bijen
authors.initials: B
authors.lastname: Nazliel
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Biyikli
authors.forename: Zulal
authors.initials: Z
authors.lastname: Yesilbudak
authors.forename: Sirel
authors.initials: S
authors.lastname: Karakas
authors.forename: Ceyla
authors.initials: C
authors.lastname: Irkec
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000503:physiopathology; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*; D004185:Disability Evaluation; D018450:Disease Progression; D004569:Electroencephalography / Q000379:methods*; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D007859:Learning Disabilities / Q000175:diagnosis / Q000503:physiopathology; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000503:physiopathology; D009103:Multiple Sclerosis / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology*; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D011930:Reaction Time / Q000502:physiology; D055815:Young Adult