Effect of methylenetetrahydrofolate reductase and thymidylate synthase enhancer region polymorphisms on the risk of idiopathic recurrent spontaneous abortion in a Korean population.
Previous studies reported an association of methylenetetrahydrofolate reductase (MTHFR) polymorphisms and recurrent spontaneous abortion, whereas no studies are available for the association with thymidylate synthase enhancer region (TSER) genotypes. Mutations of MTHFR and TSER are not likely significant risk factors of idiopathic recurrent spontaneous abortion in Korean women.
Bae
Jeehyeon
J
Institute for Clinical Research, Bundang CHA General Hospital, College of Medicine, Pochon CHA University, Seongnam, South Korea.
Choi
Dong Hee
DH
Kang
Myung Seo
MS
Cha
Sun Hee
SH
Oh
Doyeun
D
Kim
Nam Keun
NK
D000022:Abortion, Spontaneous / Q000208:ethnology* / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D004742:Enhancer Elements, Genetic / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D007723:Korea; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012008:Recurrence; D012307:Risk Factors; D013940:Thymidylate Synthase / Q000235:genetics*
D042965:Methylenetetrahydrofolate Reductase (NADPH2); D013940:Thymidylate Synthase