title: Integrity of foveal photoreceptor layer in central retinal vein occlusion.
abstract: OBJECTIVE
  To study the correlation between final visual acuity and integrity of the foveal photoreceptor layer after resolution of macular edema (ME) associated with central retinal vein occlusion (CRVO).
  
  
  METHODS
  We studied retrospectively 27 eyes of 27 patients with resolved ME associated with central retinal vein occlusion. On optical coherence tomography, integrity of the foveal photoreceptor layer was studied using the junctions between inner and outer segments of the photoreceptor (IS/OS) line as a hallmark.
  
  
  RESULTS
  At the final visit, foveal thickness was decreased to a physiologic level in all eyes. On optical coherence tomography, 14 eyes showed the IS/OS line in the fovea, whereas 13 eyes showed no IS/OS line. In concordance with resolution of the ME, visual acuity had improved significantly by the final visit. However, final visual acuity in eyes without an IS/OS line was significantly poorer than that in eyes with an IS/OS line (P < 0.0001). In addition, integrity of the foveal photoreceptor layer after resolution of the ME had a significant correlation with the initial retinal perfusion status (P = 0.0156) and with initial visual acuity (P = 0.0050).
  
  
  CONCLUSIONS
  After resolution of the ME associated with central retinal vein occlusion, visual acuity is closely associated with integrity of the foveal photoreceptor layer.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Ota
authors.forename: Akitaka
authors.initials: A
authors.lastname: Tsujikawa
authors.forename: Mihori
authors.initials: M
authors.lastname: Kita
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Miyamoto
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sakamoto
authors.forename: Noritatsu
authors.initials: N
authors.lastname: Yamaike
authors.forename: Yuriko
authors.initials: Y
authors.lastname: Kotera
authors.forename: Nagahisa
authors.initials: N
authors.lastname: Yoshimura
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005451:Fluorescein Angiography; D005584:Fovea Centralis / Q000473:pathology*; D006801:Humans; D008269:Macular Edema / Q000175:diagnosis / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy; D055211:Retinal Photoreceptor Cell Inner Segment / Q000473:pathology* / Q000502:physiology; D055214:Retinal Photoreceptor Cell Outer Segment / Q000473:pathology* / Q000502:physiology; D012170:Retinal Vein Occlusion / Q000175:diagnosis* / Q000503:physiopathology; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology