title: Efficacy of Bosentan in treatment of refractory sclerodermic bone prominences skin ulcers.
abstract: Scleroderma is an autoimmune disease characterized by skin and internal organs involvement. Cutaneous ulcerations is one of the most important complication. It may cause pain, disability and may lead to infections, scarring and amputation. Sclerodermic skin ulcers management is quite complex and involves non-pharmacologic and pharmacologic modalities both for the treatment and the prevention. In this report, authors describe a case of refractory skin ulcerations in a sclerodermic patient treated with endothelin receptor antagonist Bosentan. Bosentan changed the course of cutaneous lesions leading to their complete healing. This treatment represents an alternative therapeutic approach for sclerodermic skin ulcers and it may be taken into consideration for the ongoing development of a new management of cutaneous wounds.
authors.affiliation: Dipartimento di Dermatologia e Venereologia e Chirurgia Plastica e Ricostruttiva, Università La Sapienza, Policlinico Umberto I, Roma, Italia. antoniorichetta@hotmail.com
authors.forename: A G
authors.initials: AG
authors.lastname: Richetta
authors.forename: C
authors.initials: C
authors.lastname: Mattozzi
authors.forename: E
authors.initials: E
authors.lastname: Maiani
authors.forename: S
authors.initials: S
authors.lastname: D'Epiro
authors.forename: M
authors.initials: M
authors.lastname: Cimillio
authors.forename: V
authors.initials: V
authors.lastname: Carboni
authors.forename: S
authors.initials: S
authors.lastname: Giancristoforo
authors.forename: S
authors.initials: S
authors.lastname: Calvieri
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000843:Ankle Joint / Q000473:pathology*; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D001842:Bone and Bones; D000077300:Bosentan; D065128:Endothelin Receptor Antagonists; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D012595:Scleroderma, Systemic / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D012720:Severity of Illness Index; D013449:Sulfonamides / Q000008:administration & dosage*; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: D000959:Antihypertensive Agents; D065128:Endothelin Receptor Antagonists; D013449:Sulfonamides; D000077300:Bosentan