title: Predictors to assess non-sentinel lymph node status in breast cancer patients with sentinel lymph node metastasis.
abstract: The next step of sentinel lymph node biopsy (SLNB) in breast cancer is to determine which patients need axillary lymph node dissection (ALND) following a positive SLNB. A prospective database of 239 patients who underwent SLNB followed by complete ALND at Keio University Hospital from January 2001 to June 2005 was reviewed. A total of 131 patients with one or more positive sentinel lymph nodes (SLNs) were further analyzed. A univariate analysis showed a significant correlation between non-SLN involvement and lymphatic invasion, vascular invasion, number of tumor-involved SLNs, radioactivity of SLNs, and size of SLN metastasis (p = 0.0002, p = 0.004, p = 0.006, p = 0.04, p = 0.03, respectively). By multivariate analysis, lymphatic invasion and the number of tumor-involved SLNs remained significant predictors of non-SLN involvement. In breast cancer patients with a positive SLN, lymphatic invasion and the number of tumor-involved SLNs were both independent predictors of non-SLN involvement.
authors.affiliation: Department of Surgery, Keio University School of Medicine, Tokyo, Japan. jinno@sc.itc.keio.ac.jp
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Jinno
authors.forename: Michio
authors.initials: M
authors.lastname: Sakata
authors.forename: Sota
authors.initials: S
authors.lastname: Asaga
authors.forename: Masahiro
authors.initials: M
authors.lastname: Wada
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Shimada
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kitagawa
authors.forename: Takayuki
authors.initials: T
authors.lastname: Suzuki
authors.forename: Tadaki
authors.initials: T
authors.lastname: Nakahara
authors.forename: Naoto
authors.initials: N
authors.lastname: Kitamura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kubo
authors.forename: Makio
authors.initials: M
authors.lastname: Mukai
authors.forename: Tadashi
authors.initials: T
authors.lastname: Ikeda
authors.forename: Masaki
authors.initials: M
authors.lastname: Kitajima
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D044584:Carcinoma, Ductal / Q000473:pathology / Q000601:surgery; D018275:Carcinoma, Lobular / Q000473:pathology / Q000601:surgery; D004210:Dissection; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000473:pathology*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010173:Palpation; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D021701:Sentinel Lymph Node Biopsy / Q000706:statistics & numerical data*; D015996:Survival Rate
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone