Finding the right partner: science or ART?
In response to environmental cues, certain plasma membrane proteins are ubiquitinated, signaling their endocytosis and degradation. In the budding yeast, a single enzyme, Rsp5, is charged with this task. Lin et al. (2008) now identify an arrestin-related family of Rsp5 adaptor proteins called ARTs that confer specificity on the ubiquitination of plasma membrane proteins and contribute to the maintenance of the correct cell surface protein repertoire.
Polo
Simona
S
IFOM, Istituto FIRC di Oncologia Molecolare, Milano, Italy. simona.polo@ifom-ieo-campus.it
Di Fiore
Pier Paolo
PP
D020816:Amino Acid Motifs; D000818:Animals; D019390:Arrestins / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D004705:Endocytosis; D056827:Endosomal Sorting Complexes Required for Transport; D005656:Fungal Proteins / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism; D043743:Ubiquitin-Protein Ligase Complexes / Q000378:metabolism
D019390:Arrestins; D056827:Endosomal Sorting Complexes Required for Transport; D005656:Fungal Proteins; D029701:Saccharomyces cerevisiae Proteins; D025801:Ubiquitin; D043743:Ubiquitin-Protein Ligase Complexes; C469287:RSP5 protein, S cerevisiae