title: A new phloroglucinol diglycoside derivative from Hypericum japonicum Thunb.
abstract: A new phloroglucinol diglycoside 1, together with eight known compounds, were isolated from Hypericum japonicum Thunb. The structure of the new compound 1 was determined by spectroscopic methods to be 4,6-dimethyl-5-O-[alpha-L-rhamnopyranosyl-(1-->6)-alpha-D-glucopyranosyl] multifidol. Different solvent extracts of Hypericum japonicum Thunb. were tested for in vivo antihypoxic activity using mice, with the EtOAc extract showing better activity.
authors.affiliation: Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang, Liaoning, PR China.
authors.forename: Xiao Wei
authors.initials: XW
authors.lastname: Wang
authors.forename: Yu
authors.initials: Y
authors.lastname: Mao
authors.forename: Nai-Li
authors.initials: NL
authors.lastname: Wang
authors.forename: Xin Sheng
authors.initials: XS
authors.lastname: Yao
mesh_terms: D000818:Animals; D004187:Disaccharides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020902:Hypericum / Q000737:chemistry*; D000860:Hypoxia / Q000188:drug therapy*; D051379:Mice; D015394:Molecular Structure; D013057:Spectrum Analysis
chemical_list: C534556:4,6-dimethyl-5-O-(alpha-L-rhamnopyranosyl-(1-6)-alpha-D-glucopyranosyl); D004187:Disaccharides; D006027:Glycosides