title: Hemicrania continua evolving from cluster headache responsive to valproic acid.
abstract: Hemicrania continua (HC) is a rare type of primary headache characterized by a prompt and enduring response to indomethacin. We describe a patient who suffered from cluster headache evolving into ipsilateral HC, who does not tolerate a long-term indomethacin therapy. The case was complex in terms of diagnosis, associated comorbidity, and choice of treatment; after several trials with different therapeutic regimens, we started the patient on a therapy with valproic acid and obtained an improvement of her HC.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Lambru
authors.forename: Paola
authors.initials: P
authors.lastname: Castellini
authors.forename: Annamaria
authors.initials: A
authors.lastname: Bini
authors.forename: Andrea
authors.initials: A
authors.lastname: Evangelista
authors.forename: Gian Camillo
authors.initials: GC
authors.lastname: Manzoni
authors.forename: Paola
authors.initials: P
authors.lastname: Torelli
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D003863:Depression / Q000150:complications / Q000188:drug therapy; D004415:Dyspepsia / Q000139:chemically induced; D005260:Female; D018682:GABA Agents / Q000627:therapeutic use*; D005756:Gastritis / Q000139:chemically induced; D020773:Headache Disorders / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology*; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects; D008875:Middle Aged; D016584:Panic Disorder / Q000150:complications / Q000188:drug therapy; D014635:Valproic Acid / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D018682:GABA Agents; D014635:Valproic Acid; D007213:Indomethacin