Bupropion attenuates methamphetamine self-administration in adult male rats.
Bupropion is a promising candidate medication for methamphetamine use disorder. As such, we used a preclinical model of drug-taking to determine the effects of bupropion on the reinforcing effects of methamphetamine (0.025, 0.05 or 0.1 mg/kg/infusion). Specificity was determined by investigating the effects of bupropion on responding maintained by sucrose. In the self-administration study, rats were surgically prepared with indwelling jugular catheters and trained to self-administer methamphetamine under an FR5 schedule. A separate group of rats was trained to press a lever for sucrose. Once responding stabilized, rats were pretreated with bupropion (0, 10, 30 and 60 mg/kg i.p.) 5 min before chamber placement in a unique testing order. Following acute testing, rats were then repeatedly pretreated with 30 and 60 mg/kg bupropion. Acute treatments of bupropion dose dependently reduced drug intake for 0.025-0.1 mg/kg methamphetamine; sucrose deliveries were only reduced with the high bupropion dose. Repeated exposure to 60 mg/kg bupropion before the session resulted in a consistent decrease in methamphetamine intake (0.05 and 0.1 mg/kg) and sucrose deliveries. Considered together, this pattern of findings demonstrates that bupropion decreases responding for methamphetamine, but the effects are only somewhat specific.
Reichel
Carmela M
CM
Department of Psychology, University of Nebraska-Lincoln, Lincoln, NE 68588-0308, United States.
Murray
Jennifer E
JE
Grant
Kathleen M
KM
Bevins
Rick A
RA
D019969:Amphetamine-Related Disorders / Q000517:prevention & control* / Q000523:psychology; D000818:Animals; D016739:Behavior, Addictive / Q000517:prevention & control / Q000523:psychology; D016642:Bupropion / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008694:Methamphetamine / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012646:Self Administration
D016642:Bupropion; D008694:Methamphetamine