title: Cochlear implant in children with asymptomatic congenital cytomegalovirus infection.
abstract: OBJECTIVE
  To evaluate the development of speech perception and auditory skills after cochlear implantation in deaf children with asymptomatic congenital cytomegalovirus (CMV) infection diagnosed based on the presence of CMV DNA in the neonatal urine.
  
  
  METHODS
  A prospective study of congenital CMV infection was done between 1996 and 2003. Of 18 children diagnosed with congenital CMV infection, 2 deaf children with asymptomatic CMV infections received cochlear implantation.
  
  
  RESULTS
  The 2 deaf children who received cochlear implantation had delayed-onset, progressive sensorineural hearing loss on follow-up audiometric examinations administered at 29 and 39 months of age. After cochlear implantation, their Infant-Toddler Meaningful Auditory Integration Scale scores increased consistently during 36 months of follow-up; these results were similar to those of 5 congenitally deaf children without CMV infection who had cochlear implantation.
  
  
  CONCLUSIONS
  Cochlear implantation was effective for improving the development of speech perception and auditory skills in deaf children with asymptomatic congenital CMV infection. There was no significant difference in the development of useful auditory integration between our general pediatric cochlear implant population without CMV infection and those with asymptomatic CMV infection.
authors.affiliation: Department of Otolaryngology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu City, Hamamatsu 431-3192, Japan. CBF10965@nifty.com
authors.forename: Satoshi
authors.initials: S
authors.lastname: Iwasaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakanishi
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Misawa
authors.forename: Toru
authors.initials: T
authors.lastname: Tanigawa
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Mizuta
mesh_terms: D002675:Child, Preschool; D019929:Cochlear Implantation / Q000009:adverse effects; D003586:Cytomegalovirus Infections / Q000151:congenital* / Q000453:epidemiology; D004279:DNA, Viral / Q000652:urine; D005260:Female; D005500:Follow-Up Studies; D006310:Hearing Aids; D006319:Hearing Loss, Sensorineural / Q000209:etiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007564:Japan / Q000453:epidemiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology; D011446:Prospective Studies; D013067:Speech Perception
chemical_list: D004279:DNA, Viral