title: Racemic Etodolac is cytotoxic and cytostatic for B-cell precursor acute lymphoblastic leukemia cells.
abstract: Several epidemiological studies have provided evidence that administration of nonsteroidal anti-inflammatory drugs (NSAIDs) could have a prophylactic effect against some cancers such as sporadic colorectal cancer and leukemia. Indeed, various NSAIDs have been shown to induce apoptosis in malignant cells. We evaluated the effect of racemic Etodolac on proliferation and cell survival in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells. Etodolac decreased survival of Nalm-16 and Nalm-6 BCP-ALL cell lines and also decreased cell proliferation in Nalm-16 cell line. Ours findings indicate, for the first time to our knowledge, that Etodolac is cytotoxic and cytostatic for BCP-ALL cells.
authors.affiliation: Banco de Células do Rio de Janeiro, Hospital Universitário Clementino Fraga Filho, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, UFRJ, 21941-590 Cidade Universitária, Rio de Janeiro, Brazil. leandrothiago@terra.com.br
authors.forename: Leandro
authors.initials: L
authors.lastname: de Souza Thiago
authors.forename: Elaine Sobral
authors.initials: ES
authors.lastname: da Costa
authors.forename: Daiana Vieira
authors.initials: DV
authors.lastname: Lopes
authors.forename: Radovan
authors.initials: R
authors.lastname: Borojevic
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology*; D000964:Antimetabolites, Antineoplastic / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D054697:Cytostatic Agents / Q000494:pharmacology*; D017308:Etodolac / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; D013237:Stereoisomerism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000964:Antimetabolites, Antineoplastic; D054697:Cytostatic Agents; D017308:Etodolac