Update on pathogenic mechanisms of systemic necrotizing vasculitis.
Systemic necrotizing vasculitis is rare but can have serious sequelae. Despite recent advances in cellular and molecular immunology and genetics, the causes of vasculitic syndromes remain largely undefined. Although mechanisms of blood vessel damage in systemic necrotizing vasculitis are complex, recent studies have provided significant insights.
Danila
Maria I
MI
Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, 1530 3rd Avenue South, 805 FOT, Birmingham, AL 35294, USA. Lbridges@uab.edu.
Bridges
S Louis
SL
D000818:Animals; D000936:Antigen-Antibody Complex / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology; D001808:Blood Vessels / Q000473:pathology; D004195:Disease Models, Animal; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology; D051379:Mice; D009336:Necrosis; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D014657:Vasculitis / Q000235:genetics* / Q000276:immunology* / Q000473:pathology
D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D020381:Interleukin-17