Microbial transformation of (-)-carvone.
The cyclic monoterpene ketone (-)-carvone was metabolized by the plant pathogenic fungus Absidia glauca. After 4 days of incubation, the diol 10-hydroxy-(+)-neodihydrocarveol was formed. The absolute configuration and structure of the crystalline substance was identified by means of X-ray diffraction and by spectroscopic techniques (MS, IR and NMR). The antimicrobial activity of the substrate and metabolite was assayed with human pathogenic microorganisms.
Demirci
Fatih
F
Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey. fdemirci@anadolu.edu.tr
Noma
Yoshiaki
Y
Kirimer
Neş'e
N
Can Başer
K Hüsnü
KH
D020095:Absidia / Q000378:metabolism*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001711:Biotransformation; D002176:Candida albicans / Q000187:drug effects; D000081005:Cyclohexane Monoterpenes; D008401:Gas Chromatography-Mass Spectrometry; D007654:Ketoconazole / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D039821:Monoterpenes / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared
D000972:Antineoplastic Agents, Phytogenic; D000081005:Cyclohexane Monoterpenes; D039821:Monoterpenes; C006923:carvone; D007654:Ketoconazole