title: Zotepine-induced spontaneous ejaculation.
abstract: A man with schizophrenia received regular haloperidol ester therapy, but his psychotic symptoms were not mitigated. A combination of zotepine and haloperidol was then used to relieve the psychotic symptoms. However, the patient developed spontaneous ejaculations, which occurred many times a day while undergoing haloperidol and zotepine therapy. These events were not preceded by sexual stimulation and were not associated with a pleasurable sensation. The discomfort disappeared after discontinuing zotepine. Zotepine-induced spontaneous ejaculation was, therefore, diagnosed. There are few reports of drug-related spontaneous ejaculation. Clinicians need to recognize the possibility of zotepine-related spontaneous ejaculation because sexual side effects have an impact on medical adherence.
authors.affiliation: Department of Psychiatry, Kaohsiung Kai-Suan Psychiatric Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: P-W
authors.initials: PW
authors.lastname: Wang
authors.forename: S Y
authors.initials: SY
authors.lastname: Wang
authors.forename: C-J
authors.initials: CJ
authors.lastname: Huang
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003988:Dibenzothiepins / Q000009:adverse effects* / Q000627:therapeutic use; D004542:Ejaculation / Q000187:drug effects*; D005832:Genital Diseases, Male / Q000139:chemically induced*; D006220:Haloperidol / Q000627:therapeutic use; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000188:drug therapy
chemical_list: D014150:Antipsychotic Agents; D003988:Dibenzothiepins; D006220:Haloperidol; C022172:zotepine