title: A 6-aminoquinolone compound, WC5, with potent and selective anti-human cytomegalovirus activity.
abstract: We identified a 6-aminoquinolone compound, WC5, that inhibits human cytomegalovirus (HCMV) replication with a selectivity index of approximately 500. WC5 also showed activity against drug-resistant HCMV strains. In contrast, it did not significantly affect the replication of human herpesvirus 6 and 8 and was approximately 10-fold less active against murine cytomegalovirus. Thus, WC5 may represent a lead for the development of new, potent, and selective anti-HCMV compounds.
authors.affiliation: Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Padua, Italy.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Mercorelli
authors.forename: Giulia
authors.initials: G
authors.lastname: Muratore
authors.forename: Elisa
authors.initials: E
authors.lastname: Sinigalia
authors.forename: Oriana
authors.initials: O
authors.lastname: Tabarrini
authors.forename: Maria Angela
authors.initials: MA
authors.lastname: Biasolo
authors.forename: Violetta
authors.initials: V
authors.lastname: Cecchetti
authors.forename: Giorgio
authors.initials: G
authors.lastname: Palù
authors.forename: Arianna
authors.initials: A
authors.lastname: Loregian
mesh_terms: D000634:Aminoquinolines / Q000737:chemistry / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000187:drug effects* / Q000235:genetics*; D006801:Humans; D015394:Molecular Structure; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000634:Aminoquinolines