title: Gastroprotective mechanism of Vanillosmopsis arborea bark essential oil.
abstract: This study was aimed to clarify the mechanism of gastroprotection by Vanillosmopsis arborea Baker essential oil (EOVA) using ethanol-induced gastric mucosal damage in mice. Gastric lesions were significantly reduced by EOVA (200 and 400 mg/kg). Chemical analysis showed that the major compound of EOVA was alpha-bisabolol. Pretreatment of mice with yohimbine, the alpha2-antagonist, greatly suppressed the gastroprotective effect of OEVA. Furthermore, OEVA gastroprotection was not attenuated in mice pretreated with indomethacin, L-NAME or glibenclamide, the respective inhibitors of cyclooxygenase, nitric oxide synthase and K(+)(ATP) channel activation. These data suggest that OEVA affords gastroprotection most possibly by alpha2-receptor activation.
authors.affiliation: Laboratório de Pesquisas em Produtos Naturais, Universidade Regional do Cariri, Crato, Brazil.
authors.forename: Gerlânia
authors.initials: G
authors.lastname: de O Leite
authors.forename: Antonia Rosângela
authors.initials: AR
authors.lastname: da Penha
authors.forename: Cícera N
authors.initials: CN
authors.lastname: Fernandes
authors.forename: Heloísa Helena F
authors.initials: HH
authors.lastname: Souza
authors.forename: José Galberto M
authors.initials: JG
authors.lastname: da Costa
authors.forename: Adriana R
authors.initials: AR
authors.lastname: Campos
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D000897:Anti-Ulcer Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D019659:Asteraceae / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000494:pharmacology; D000431:Ethanol; D005753:Gastric Mucosa / Q000187:drug effects*; D005905:Glyburide / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D051379:Mice; D023421:Models, Animal; D000081222:Monocyclic Sesquiterpenes; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000032:analysis; D013276:Stomach Ulcer / Q000517:prevention & control; D015016:Yohimbine / Q000494:pharmacology
chemical_list: D000317:Adrenergic alpha-Antagonists; D000897:Anti-Ulcer Agents; D004791:Enzyme Inhibitors; D000081222:Monocyclic Sesquiterpenes; D009822:Oils, Volatile; D010936:Plant Extracts; D012717:Sesquiterpenes; C004497:bisabolol; D015016:Yohimbine; D000431:Ethanol; D005905:Glyburide; D019331:NG-Nitroarginine Methyl Ester; D007213:Indomethacin