Arthrinic acid, a novel antifungal polyhydroxyacid from Arthrinium phaeospermum.
Arthrinic acid was isolated from solid state fermentations of the fungus Arthrinium phaeospermum. The structure of arthrinic acid was determined to be (6E,10E,14E,18E,20E)-2,3,5,9,13,17-hexahydroxy-20-(hydroxymethyl)-14,16,18,22,24-pentamethylhexacosa-6,10,14,18,20-pentaenoic acid from NMR spectroscopic studies.
Bloor
Stephen
S
Biodiscovery New Zealand Ltd, Lower Hutt, New Zealand. sbloor@biodiscovery.co.nz
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D006880:Hydroxy Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D019906:Nuclear Magnetic Resonance, Biomolecular; D009904:Optical Rotation; D013056:Spectrophotometry, Ultraviolet
D000935:Antifungal Agents; D006880:Hydroxy Acids