Sesquiterpene lactones from the endemic Cape Verdean Artemisia gorgonum.
Leaves and flowers of Artemisia gorgonum (Asteraceae) collected in Fogo, Cape Verde islands, were phytochemically investigated and resulted in isolation and characterization of three guaianolides 1, 2, 5, and a secoguainolide 4, in addition to eight known guaianolides 6-11 and two known germacranolides 12, 13. Structures were elucidated by 1D and 2D NMR experiments. Careful examination of the (13)C NMR spectrum led to revision of the structure of a previously described guaianolide from 2 to 3. Most compounds exhibited mild antiplasmodial activities, ridentin (13) being the most interesting with an IC(50) of 3.8+/-0.7microgml(-1) against Plasmodium falciparum FcB1 and weak cytotoxicity in a vero cell line (IC(50) 71.0+/-3.9microgml(-1)).
Ortet
Risoleta
R
Université de Nice-Sophia Antipolis, Laboratoire de Chimie des Molécules Bioactives et des Arômes, UMR 6001 CNRS, Faculté des Sciences, Nice, France.
Prado
Soizic
S
Mouray
Elisabeth
E
Thomas
Olivier P
OP
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology; D019306:Artemisia / Q000737:chemistry* / Q000378:metabolism; D055726:Cabo Verde; D002522:Chlorocebus aethiops; D035264:Flowers / Q000737:chemistry / Q000378:metabolism; D007783:Lactones / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry / Q000378:metabolism; D010963:Plasmodium falciparum / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry* / Q000378:metabolism; D014709:Vero Cells
D000972:Antineoplastic Agents, Phytogenic; D000995:Antitubercular Agents; D007783:Lactones; D012717:Sesquiterpenes