title: Highlights of a workshop to discuss targeting inflammation in cystic fibrosis.
abstract: A workshop to discuss anti-inflammatory approaches in the treatment of CF was held at Novartis Institutes for Biomedical Research (NIBR, Horsham, UK) in March 2008. Key opinion leaders in the field (Hugo De Jonge, Stuart Elborn, Erich Gulbins, Mike Konstan, Rick Moss, Scott Randell and Adriano Rossi), and NIBR scientists were brought together to collectively address three main aims: (i) to identify anti-inflammatory targets in CF, (ii) to evaluate the pros and cons of targeting specific cell types and (iii) to discuss model systems to profile potential therapeutic agents. The highlights of the workshop are captured in this review.
authors.affiliation: Novartis Institutes for Biomedical Research, Wimblehurst Road, Horsham, West Sussex, RH12 5AB, UK. kathy.banner@novartis.com
authors.forename: Katharine H
authors.initials: KH
authors.lastname: Banner
authors.forename: Hugo
authors.initials: H
authors.lastname: De Jonge
authors.forename: Stuart
authors.initials: S
authors.lastname: Elborn
authors.forename: Ellena
authors.initials: E
authors.lastname: Growcott
authors.forename: Erich
authors.initials: E
authors.lastname: Gulbins
authors.forename: Mike
authors.initials: M
authors.lastname: Konstan
authors.forename: Rick
authors.initials: R
authors.lastname: Moss
authors.forename: Chris
authors.initials: C
authors.lastname: Poll
authors.forename: Scott H
authors.initials: SH
authors.lastname: Randell
authors.forename: Adriano G
authors.initials: AG
authors.lastname: Rossi
authors.forename: Lorraine
authors.initials: L
authors.lastname: Thomas
authors.forename: David
authors.initials: D
authors.lastname: Waltz
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003550:Cystic Fibrosis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology*; D004493:Education; D004847:Epithelial Cells / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000188:drug therapy* / Q000473:pathology*; D008214:Lymphocytes / Q000378:metabolism; D008954:Models, Biological; D009504:Neutrophils / Q000378:metabolism; D012107:Research Design
chemical_list: D000893:Anti-Inflammatory Agents