title: Effects of experimentally induced panic attacks on neuroimmunological markers.
abstract: Since little is known concerning regulation of immunological parameters in rapid changing psychiatric states like panic attacks, we measured cytokines at different time points in healthy subjects, which underwent experimental panic induction using the CCK-4 paradigm. Apart from a challenge related IL-6 increase, we could not observe any changes of neuroimmunological markers in relation to acute anxiety with regard to time and group. Herein we conducted for the first time a new approach to immunological research in panic disorder, suggesting immune changes are more related to long term disease stress.
authors.affiliation: Department of Psychiatry, Ludwig-Maximilian-University, Nussbaumstr. 7, 80336 Munich, Germany.
authors.forename: L
authors.initials: L
authors.lastname: de la Fontaine
authors.forename: M J
authors.initials: MJ
authors.lastname: Schwarz
authors.forename: D
authors.initials: D
authors.lastname: Eser
authors.forename: N
authors.initials: N
authors.lastname: Müller
authors.forename: R
authors.initials: R
authors.lastname: Rupprecht
authors.forename: P
authors.initials: P
authors.lastname: Zwanzger
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood* / Q000276:immunology; D008297:Male; D016584:Panic Disorder / Q000097:blood* / Q000139:chemically induced / Q000276:immunology*; D013758:Tetragastrin / Q000633:toxicity
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D013758:Tetragastrin