title: [Osteoarticular infections: clinical studies].
abstract: Management of paediatric skeletal infections remains delicate in France due to the absence of general agreement or official recommendations from the French National Societies. However, practices have evolved since 40 years towards simplified and mostly ambulatory treatment modalities. The Paediatric Infectious Diseases Group of the French Society of Paediatrics (GPIP) has elaborated guidelines funded on the joint analysis of bacterial epidemiology, comparison of common antimicrobial spectra, pharmacokinetic and pharmacodynamic parameters and clinical studies. The aim of this article is to review the evolution of therapeutic concepts of treatment of bone and joint infections in paediatrics for 40 years with the aid of main published clinical studies.
authors.affiliation: Groupe de Pathologie Infectieuse Pédiatrique de la Société Française de Pédiatrie, Hôpital Armand Trousseau, 26 av Dr Arnold Netter 75012 Paris, Université Pierre et Marie Curie Paris VI, France. emmanuel.grimprel@trs.aphp.fr
authors.forename: E
authors.initials: E
authors.lastname: Grimprel
authors.forename: M
authors.initials: M
authors.lastname: Lorrot
authors.forename: H
authors.initials: H
authors.lastname: Haas
authors.forename: D
authors.initials: D
authors.lastname: Pinquier
authors.forename: N
authors.initials: N
authors.lastname: Parez
authors.forename: A
authors.initials: A
authors.lastname: Ferroni
authors.forename: R
authors.initials: R
authors.lastname: Cohen
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001170:Arthritis, Infectious / Q000188:drug therapy; D001424:Bacterial Infections / Q000188:drug therapy*; D001850:Bone Diseases, Infectious / Q000188:drug therapy*; D002648:Child; D002986:Clinical Trials as Topic; D006801:Humans; D007592:Joint Diseases / Q000188:drug therapy / Q000382:microbiology*; D010019:Osteomyelitis / Q000188:drug therapy; D017410:Practice Guidelines as Topic
chemical_list: D000900:Anti-Bacterial Agents