Antischistosomal activity of aminoalkanethiols, aminoalkanethiosulfuric acids and the corresponding disulfides.
This paper discusses the development of a series of sulfur-containing compounds that show an interesting in vivo activity against infection by Schistosoma mansoni. These substances include the aminoalkanethiols, aminoalkanethiosulfuric acids and aminoalkyl disulfides, among others. Although the aminoethanethiols and their disulfide derivatives have presented a relatively high toxicity for the host animal, the aminoalkanethiosulfuric acids have a low toxicity and a high specificity for the adult female S. mansoni worms. In vitro studies with schistosomula, lung-phase schistosomula and adult worms have demonstrated effects on the tegument and the metabolism on these different stages of S. mansoni worms. The encapsulation of these drugs in a nanoemulsion has resulted in an increase in the in vitro activity.
de Oliveira Penido
Marcus Luiz
ML
Departamento de Bioquímica-Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais e Instituto Medicina Legal, Belo Horizonte, MG, Brazil.
Zech Coelho
Paulo Marcos
PM
de Mello
Rômulo Teixeira
RT
Piló-Veloso
Dorila
D
de Oliveira
Mônica Cristina
MC
Kusel
John Robert
JR
Nelson
David Lee
DL
D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity*; D005260:Female; D006801:Humans; D051379:Mice; D012550:Schistosoma mansoni / Q000187:drug effects*; D012555:Schistosomiasis mansoni / Q000188:drug therapy*; D013457:Sulfur Compounds / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity*
D000981:Antiprotozoal Agents; D013457:Sulfur Compounds