title: Possible involvement of phospholipase A(2) and cyclooxygenase in stimulatory action of L-histidine on protein synthesis in L6 myotubes.
abstract: Effects of L-histidine and related compounds on protein synthesiswere studied in cultured L6 myotubes. L-Histidine specifically stimulated protein synthesis, whereas D-histidine, histamine, L-arginine and L-lysine did not. Inhibitors of phospholipase A(2), phospholipase C and cyclooxygenase intercepted the stimulatory action of L-histidine on protein synthesis, while inhibitors of protein kinase C and 5-lipoxygenase did not. These results suggest an involvement of phospholipase A(2) and cyclooxygenase in the stimulatory action of L-histidine on protein synthesis in L6 myotubes.
authors.affiliation: Department of Applied Biological Science, Tokyo Noko University, Saiwaicho 3-5-8, Fuchu, Tokyo, 183-8509, Japan, yagasaki@cc.tuat.ac.jp.
authors.forename: Kazumi
authors.initials: K
authors.lastname: Yagasaki
authors.forename: Naoko
authors.initials: N
authors.lastname: Hatano
authors.forename: Motoki
authors.initials: M
authors.lastname: Fujii
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Miura
authors.forename: Ryuhei
authors.initials: R
authors.lastname: Funabiki