Ependymoma of the sella turcica: a variant of pituicytoma.
A broad spectrum of neoplasms affects the sellar region. Among these, gliomas are rare, most being tumors of pituicytes such as granular cell tumor and pituicytoma. Only 4 ependymomas of the human sellar region have been reported to date and all have had classic histologic features. Herein, we describe the clinicopathologic features of a sellar, low-grade ependymoma with unusual histology, but classic ultrastructural features, occurring in an elderly patient and thus expanding the spectrum of reported cases. The literature is reviewed and concepts of histogenesis are explored, particularly an origin in "ependymal pituicytes." The concept that sellar ependymoma is pituicyte-derived is explored.
Scheithauer
Bernd W
BW
Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN 55905, USA. scheithauer.bernd@mayo.edu
Swearingen
Brooke
B
Whyte
E Tessa Hedley
ET
Auluck
Pavan K
PK
Stemmer-Rachamimov
Anat O
AO
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D003937:Diagnosis, Differential; D004806:Ependymoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007124:Immunoenzyme Techniques; D007382:Intermediate Filaments / Q000648:ultrastructure; D008297:Male; D008579:Meningioma / Q000175:diagnosis; D046529:Microscopy, Electron, Transmission; D010904:Pituitary Gland, Posterior / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D010911:Pituitary Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D012509:Sarcoma / Q000175:diagnosis; D012658:Sella Turcica / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed
D014408:Biomarkers, Tumor