Anaphylaxis and superior vena cava thrombus in a pediatric patient with acute lymphoblastic leukemia.
Pediatric patients with malignancies are at significant risk for complications from their underlying condition and medical therapy. Emergency medicine physicians must be quick to suspect life-threatening events, which can present insidiously. We describe a case of anaphylaxis and superior vena cava syndrome in an 18-year-old female patient after polyethylene glycol-conjugated asparaginase chemotherapy for acute lymphoblastic leukemia. Pertinent literature surrounding risk factors, diagnosis, and treatment is also reviewed.
Creel
Amy M
AM
Department of Pediatric Critical Care, University of Alabama at Birmingham, USA. acree1@lsuhsc.edu
Crawford
David
D
Prabhakaran
Priya
P
D000293:Adolescent; D000707:Anaphylaxis / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D001215:Asparaginase / Q000008:administration & dosage / Q000009:adverse effects; D004636:Emergency Service, Hospital; D004638:Emergency Treatment; D005260:Female; D005500:Follow-Up Studies; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D007262:Infusions, Intravenous; D010690:Phlebography; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000009:adverse effects; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000188:drug therapy; D018570:Risk Assessment; D013927:Thrombosis / Q000139:chemically induced* / Q000175:diagnosis* / Q000188:drug therapy; D014057:Tomography, X-Ray Computed; D014683:Vena Cava, Superior / Q000000981:diagnostic imaging*; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects
D011092:Polyethylene Glycols; D014750:Vincristine; C042705:pegaspargase; D006493:Heparin; D001215:Asparaginase