title: Ionic and neuromodulatory regulation of burst discharge controls frequency tuning.
abstract: Sensory neurons encode natural stimuli by changes in firing rate or by generating specific firing patterns, such as bursts. Many neural computations rely on the fact that neurons can be tuned to specific stimulus frequencies. It is thus important to understand the mechanisms underlying frequency tuning. In the electrosensory system of the weakly electric fish, Apteronotus leptorhynchus, the primary processing of behaviourally relevant sensory signals occurs in pyramidal neurons of the electrosensory lateral line lobe (ELL). These cells encode low frequency prey stimuli with bursts of spikes and high frequency communication signals with single spikes. We describe here how bursting in pyramidal neurons can be regulated by intrinsic conductances in a cell subtype specific fashion across the sensory maps found within the ELL, thereby regulating their frequency tuning. Further, the neuromodulatory regulation of such conductances within individual cells and the consequences to frequency tuning are highlighted. Such alterations in the tuning of the pyramidal neurons may allow weakly electric fish to preferentially select for certain stimuli under various behaviourally relevant circumstances.
authors.affiliation: Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
authors.forename: W Hamish
authors.initials: WH
authors.lastname: Mehaffey
authors.forename: Lee D
authors.initials: LD
authors.lastname: Ellis
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Krahe
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Dunn
authors.forename: Maurice J
authors.initials: MJ
authors.lastname: Chacron
mesh_terms: D000200:Action Potentials / Q000187:drug effects* / Q000502:physiology*; D000818:Animals; D055592:Biophysical Phenomena; D004555:Electric Fish / Q000502:physiology; D004558:Electric Stimulation / Q000379:methods; D066298:In Vitro Techniques; D007473:Ion Channels / Q000502:physiology*; D008959:Models, Neurological; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D017966:Pyramidal Cells / Q000187:drug effects / Q000502:physiology; D012249:Rhombencephalon / Q000166:cytology / Q000502:physiology; D013997:Time Factors
chemical_list: D007473:Ion Channels; D018377:Neurotransmitter Agents