Autophagy gives a nod and a wink to the inflammasome and Paneth cells in Crohn's disease.
Recent genome-wide association studies have linked polymorphisms in two atophagy genes, Atg16L1 and IRGM, with Crohn's Disease. Now, experiments with Atg16L1 transgenic mice indicate multiple roles for autophagy in inflammatory bowel disease via effects on Paneth cells, a runaway inflammasome, and the proinflammatory cytokine IL-1beta.
Deretic
Vojo
V
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, The University of New Mexico, Northeast Albuquerque, NM 87131, USA. vderetic@salud.unm.edu
Master
Sharon
S
Singh
Sudha
S
D000818:Animals; D001343:Autophagy; D000071183:Autophagy-Related Proteins; D002352:Carrier Proteins / Q000235:genetics / Q000276:immunology; D003424:Crohn Disease / Q000235:genetics / Q000276:immunology*; D019204:GTP-Binding Proteins / Q000235:genetics; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D053473:Nod2 Signaling Adaptor Protein / Q000276:immunology*; D019879:Paneth Cells / Q000276:immunology*
C532820:Atg16l1 protein, mouse; D000071183:Autophagy-Related Proteins; D002352:Carrier Proteins; C096000:Ifi1 protein, mouse; D053473:Nod2 Signaling Adaptor Protein; D019204:GTP-Binding Proteins