title: Benefits of exercise training in diabetic rats persist after three weeks of detraining.
abstract: Regarding all benefits of exercise training, a question remains: how long are these benefits kept? This study evaluated the effect of 3-week detraining after 10 weeks of training in STZ-diabetic rats. Male Wistar rats were assigned into: sedentary controls, trained controls, trained-detrained controls, sedentary diabetic, trained diabetic and trained-detrained diabetic. Arterial pressure (AP) and heart rate (HR) were recorded by a data acquisition system. Baroreflex sensitivity (BRS) was evaluated by HR responses to AP changes induced by infusion of vasoactive drugs. Intrinsic heart rate (IHR), sympathetic tonus (ST) and vagal tonus (VT) were evaluated by pharmacological blockade with atenolol and atropine. Spectral analysis of systolic AP and HR variabilities (HRV) was performed to estimate autonomic modulation to the heart and vessels. Diabetes cardiovascular and autonomic dysfunctions were reversed by exercise training and partially maintained in the 3-week detraining period. In controls, training decreased AP and HR and improved BRS, changes that returned to baseline values after detraining. IHR and VT were improved in trained diabetic rats and remained in detrained diabetic ones. LF component of HRV decreased in trained control group. In diabetics, exercise training improved variance, and absolute LF and HF components of HRV. Only HF was maintained in detrained diabetic group. Moreover, there was an inverse relationship between plasma glucose and the absolute HF component of HRV. These changes probably determined the different survival rate of 80% in diabetic detrained and 51% in diabetic sedentary rats.
authors.affiliation: Heart Institute (InCor), University of Sao Paulo - Medical School - FMUSP, Brazil.
authors.forename: Cristiano
authors.initials: C
authors.lastname: Mostarda
authors.forename: Andre
authors.initials: A
authors.lastname: Rogow
authors.forename: Ivana C Moraes
authors.initials: IC
authors.lastname: Silva
authors.forename: Raquel N
authors.initials: RN
authors.lastname: De La Fuente
authors.forename: Luciana
authors.initials: L
authors.lastname: Jorge
authors.forename: Bruno
authors.initials: B
authors.lastname: Rodrigues
authors.forename: Marcelo V
authors.initials: MV
authors.lastname: Heeren
authors.forename: Elia G
authors.initials: EG
authors.lastname: Caldini
authors.forename: Katia
authors.initials: K
authors.lastname: De Angelis
authors.forename: Maria Cláudia
authors.initials: MC
authors.lastname: Irigoyen
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology* / Q000628:therapy*; D006339:Heart Rate / Q000502:physiology; D008297:Male; D010805:Physical Conditioning, Animal / Q000379:methods*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors