Advanced glycation end products in pregnancies complicated with diabetes mellitus or preeclampsia.
OBJECTIVE
Preeclampsia (PE) and diabetes mellitus (DM) are associated with oxidative stress. DM is complicated with formation of advanced glycation end products (AGEs), which are associated with oxidative stress. We hypothesized that elevated serum AGE would be found in pregnancies complicated by PE or DM.


METHODS
Circulating AGEs, 8-isoprostane, vitamin E, and antioxidant capacity were analyzed from study patients.


RESULTS
Serum AGE was elevated both in patients with type 1 DM and gestational DM, but not in PE, compared with controls. 8-isoprostane was elevated in patients with type 1 DM and PE compared with controls.


CONCLUSIONS
AGEs and 8-isoprostane are not elevated in parallel in pregnancies complicated with PE or DM, suggesting biological heterogeneity.
Harsem
Nina K
NK
Department of Obstetrics and Gynecology, Ulleval University Hospital, Oslo, Norway. niem@uus.no
Braekke
Kristin
K
Torjussen
Tale
T
Hanssen
Kristian
K
Staff
Anne Cathrine
AC
D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000097:blood*; D015237:Dinoprost / Q000031:analogs & derivatives / Q000097:blood; D005260:Female; D005290:Ferric Compounds / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000097:blood*; D006801:Humans; D008239:Lysine / Q000031:analogs & derivatives* / Q000097:blood; D018384:Oxidative Stress; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood*; D014810:Vitamin E / Q000097:blood; D055815:Young Adult
D015415:Biomarkers; D005290:Ferric Compounds; D017127:Glycation End Products, Advanced; D014810:Vitamin E; C075750:8-epi-prostaglandin F2alpha; C048496:N(6)-carboxymethyllysine; D015237:Dinoprost; D008239:Lysine