Polyethylenimine in medicinal chemistry.
Polyethylenimine (PEI), an organic branched or linear polyamine polymer, has been successfully used in the past for DNA complexation and transfection in vitro and in vivo into several cell lines and tissues. PEI was also applied in different fields from gene therapy and several studies have emphasized the importance of this polymer in medicinal chemistry. In this brief critical review the uses and applications of this versatile polymeric molecule will be discussed.
Vicennati
Paola
P
Chemistry Department, SAPIENZA University of Rome, Piazzale Aldo Moro 5, Rome, Italy.
Giuliano
Antonella
A
Ortaggi
Giancarlo
G
Masotti
Andrea
A
D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D002626:Chemistry, Pharmaceutical / Q000379:methods* / Q000639:trends; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry; D010778:Photochemotherapy / Q000379:methods; D011094:Polyethyleneimine / Q000008:administration & dosage / Q000737:chemistry* / Q000627:therapeutic use
D000890:Anti-Infective Agents; D020099:Coated Materials, Biocompatible; D011094:Polyethyleneimine