Potential role of lycopene in the treatment of hepatitis C and prevention of hepatocellular carcinoma.
Hepatitis C virus (HCV) infection and hepatocellular carcinoma (HCC) are growing health problems around the world. Oxidative stress plays a significant role in the initiation and progression of hepatocellular damage and possibly in the development of HCC in HCV infected patients. In vitro, animal and clinical studies suggest that lycopene, a nonprovitamin A carotenoid and a potent antioxidant, may attenuate the liver injury and possibly prevent the development of HCC. In this article, we discuss the relationship between HCV infection and oxidative stress and review the potential role of lycopene in the treatment of HCV and prevention of HCC.
Seren
Soley
S
Department of Medicine, Wayne State University, Detroit, MI, USA.
Mutchnick
Milton
M
Hutchinson
Daryl
D
Harmanci
Ozgur
O
Bayraktar
Yusuf
Y
Mutchnick
Sean
S
Sahin
Kazim
K
Kucuk
Omer
O
D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000517:prevention & control*; D002338:Carotenoids / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D008103:Liver Cirrhosis / Q000378:metabolism; D008113:Liver Neoplasms / Q000378:metabolism / Q000517:prevention & control*; D000077276:Lycopene; D018384:Oxidative Stress
D016588:Anticarcinogenic Agents; D000975:Antioxidants; D002338:Carotenoids; D000077276:Lycopene