title: The synthesis and biological evaluation of 10-O-dialkylaminoethyl ginkgolide B as platelet-activating factor antagonist.
abstract: Four nitrogen-containing derivatives of ginkgolide B were synthesized to improve the physical-chemical properties and bioavailability of ginkgolide B. The reaction was accomplished with the nitrogen atom as neighboring group participating in the replacement reaction. All of the four compounds were proved to have excellent inhibiting effect on rabbit platelet aggregation induced by platelet-activating factor which is as well as ginkgolide B.
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, China.
authors.forename: Chun-Jun
authors.initials: CJ
authors.lastname: Guo
authors.forename: Yi
authors.initials: Y
authors.lastname: Ren
authors.forename: Yin-Lin
authors.initials: YL
authors.lastname: Qin
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D000818:Animals; D046934:Ginkgolides / Q000138:chemical synthesis* / Q000494:pharmacology*; D015394:Molecular Structure; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011817:Rabbits
chemical_list: D046934:Ginkgolides; D010972:Platelet Activating Factor; D010975:Platelet Aggregation Inhibitors