title: Distinctive features of foreskin condylomata acuminata associated with diabetes mellitus.
abstract: The aim of this study was to test the hypothesis that particular clinical features of foreskin condylomata acuminata in Chinese male patients are associated with diabetes. A prospective study enrolled 126 men presenting with foreskin condylomata acuminata from 2001 to 2006. Mean age was 46 years (age range 25-74 years) and mean duration of disease was 4.8 months (range 1-18 months). Patients were divided into two groups according to clinical features. In group 1, 42 men had distinctive signs such as redundant prepuce, crown warts circling the entire preputial ring, maceration, fissures, phimosis and balanitis, and 37 of 42 (88%) patients were found to have concurrent type 2 diabetes, furthermore 32 of these 37 patients had an insidious onset and were previously undiagnosed. In group 2, 84 male patients did not have those distinctive clinical features and type 2 diabetes was found in only 10 cases (11.9%, p<0.0001, Fisher's exact test). These clinical features strongly suggest the presence of diabetes. Therapy should address diabetes and condylomata concurrently.
authors.affiliation: Department of Dermatology and Venereology, Shanghai Skin Diseases and STD Hospital, Wuyi Rood 196, Shanghai, China. xiuliwang2001@yahoo.com.cn
authors.forename: Xiu L
authors.initials: XL
authors.lastname: Wang
authors.forename: Hong W
authors.initials: HW
authors.lastname: Wang
authors.forename: Peter
authors.initials: P
authors.lastname: Hillemanns
authors.forename: Michael R
authors.initials: MR
authors.lastname: Hamblin
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D002681:China / Q000453:epidemiology; D002944:Circumcision, Male; D003218:Condylomata Acuminata / Q000188:drug therapy / Q000821:virology*; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D052816:Foreskin / Q000473:pathology* / Q000821:virology; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D016712:Mupirocin / Q000627:therapeutic use; D009281:Naphthalenes / Q000627:therapeutic use; D009894:Opportunistic Infections / Q000188:drug therapy / Q000453:epidemiology / Q000821:virology*; D010409:Penile Diseases / Q000473:pathology* / Q000628:therapy / Q000821:virology; D011446:Prospective Studies; D000077291:Terbinafine
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D009281:Naphthalenes; D016712:Mupirocin; D000077291:Terbinafine