[Sleep patterns and the efficiency of the gentle methods of sleep deprivation in rats at different stages of pregnancy: behavioral study].
In Wistar rats, pregnant or not pregnant, sleep-wakefulness parameters were registered for 2 days from 10:00 till 14:00. Later, these rats were subjected to 3-hour (11:00-14:00) daily sleep deprivation (SD) during 3 consecutive days. To prevent sleep, the following manipulations were used: acoustic stimulation from moving of the food pellets, opening or horizontal rotation of the cage and gentle handling. Control pregnant or not pregnant rats were placed in individual cages in the same room, but their sleep was not disturbed. On average, not pregnant rats spent about 65% of the time in sleep. Sleep episodes were mostly short (less than 1 min) or medium (1-15 min). After the beginning and with advance of pregnancy, the amount, deepness and duration of sleep episodes increased. With the methods of SD used, not pregnant rats did not sleep almost at all during the SD session. In pregnant rats, the quantity and intensity of stimuli used for SD increased as compared to control, which was indicatives of the growth of "sleep pressure" during pregnancy.
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D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D005260:Female; D008297:Male; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012890:Sleep / Q000502:physiology*; D012892:Sleep Deprivation / Q000503:physiopathology*; D012894:Sleep Stages / Q000502:physiology; D014851:Wakefulness / Q000502:physiology