title: Leptin predicts diabetes but not cardiovascular disease: results from a large prospective study in an elderly population.
abstract: OBJECTIVE
  To clarify the association of circulating levels of leptin with risk for cardiovascular disease (CVD) events and new-onset diabetes in men and women.
  
  
  METHODS
  We related baseline leptin levels to CVD events (n = 864) and incident diabetes (n = 289) in an elderly population (n = 5,672) over 3.2 years of follow-up.
  
  
  RESULTS
  In treatment-, age-, and country-adjusted models, leptin was not associated with risk of CVD in men (hazard ratio 1.02 [95% CI 0.90-1.16] per unit log-leptin increase) or women (1.05 [0.91-1.20]) but was associated with risk of diabetes in men (2.75 [2.14-3.52]) and women (1.54 [1.22-1.94]). After adjusting for classic risk factors and BMI, C-reactive protein, and glucose, the diabetes association retained significance in men (1.85 [1.30-2.63]) but not in women (0.89 [0.64-1.26]).
  
  
  CONCLUSIONS
  Leptin, similar to other markers of adiposity in general, is more strongly related to risk of diabetes than CVD in the elderly.
authors.affiliation: Faculty of Medicine, University of Glasgow, Scotland, UK. p.welsh@clinmed.gla.ac.uk
authors.forename: Paul
authors.initials: P
authors.lastname: Welsh
authors.forename: Heather M
authors.initials: HM
authors.lastname: Murray
authors.forename: Brendan M
authors.initials: BM
authors.lastname: Buckley
authors.forename: Anton J M
authors.initials: AJ
authors.lastname: de Craen
authors.forename: Ian
authors.initials: I
authors.lastname: Ford
authors.forename: J Wouter
authors.initials: JW
authors.lastname: Jukema
authors.forename: Peter W
authors.initials: PW
authors.lastname: Macfarlane
authors.forename: Chris J
authors.initials: CJ
authors.lastname: Packard
authors.forename: David J
authors.initials: DJ
authors.lastname: Stott
authors.forename: Rudi G J
authors.initials: RG
authors.lastname: Westendorp
authors.forename: James
authors.initials: J
authors.lastname: Shepherd
authors.forename: Naveed
authors.initials: N
authors.lastname: Sattar
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D003920:Diabetes Mellitus / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007494:Ireland / Q000453:epidemiology; D020738:Leptin / Q000097:blood*; D008297:Male; D009203:Myocardial Infarction / Q000453:epidemiology; D009426:Netherlands / Q000453:epidemiology; D016016:Proportional Hazards Models; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012606:Scotland / Q000453:epidemiology; D020521:Stroke / Q000453:epidemiology / Q000401:mortality
chemical_list: D015415:Biomarkers; D020738:Leptin