[Study on Cornu Bos grunniens from Tibet substituting Cornu Rhinoceri].
OBJECTIVE
Comparing the pyretolysis effect of Cornu Rhinoceri Soup, an ancient prescription of Traditional Chinese Medicine, on fever model of rabbits after Cornu Bos grunniens from Tibet substituting Cornu Rhinoceri, in order to find the succedaneums of Cornu Rhinoceri, a rare animal medicine.


METHODS
The fever model was made by over-due Triple-Vaccine i.v. through the vein of rabbit in edge ear. 1 hour later, the different decoctions i.g. in different groups of rabbits, then detecting the dynamic changes of body temperature in fever rabbits.


RESULTS
1 hour after the decoction i.g., there were significant pyretolysis effects in the Cornu Bos grunniens groups of rabbits with large and small dosage (P < 0.05 or 0.01). After 2h,the same effect showed in the Cornu Bubali group with large dosage (P < 0.05 or 0.01) and 3h later in small one. In the groups of Cornu Rhinoceri, large dosage i.g. 1 h later, the rising amplitude of body temperature in fever rabbits was slower comparing to the model group. 2h later, there were the same effects as other groups.


CONCLUSIONS
The pyretolysis effect of Cornu Rhinoceri Soup on fever model rabbits is as same as it of which containing Cornu Bos grunniens instead of Cornu Rhinoceri. It means that the Cornu Bos grunniens from Tibet could be the substitution of Cornu Rhinoceri.
Shen
Ming-Qin
MQ
Jiangsu Provincial Institute of Traditional Chinese Medicine, Nanjing 210028, China. mqshen@163.com
Ye
Qi-Zheng
QZ
Ding
Yong-Fang
YF
Luo
Yu-Hui
YH
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects; D002020:Buffaloes; D002417:Cattle / Q000145:classification; D004195:Disease Models, Animal; D004338:Drug Combinations; D005260:Female; D005334:Fever / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D008419:Materia Medica / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D011817:Rabbits; D011897:Random Allocation; D018609:Tibet
D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D008419:Materia Medica