Terahertz pulsed imaging, a novel process analytical tool to investigate the coating characteristics of push-pull osmotic systems.
The aim of this study was to investigate coating characteristics of push-pull osmotic systems (PPOS) using three-dimensional terahertz pulsed imaging (3D-TPI) and to detect physical alterations potentially impacting the drug release. The terahertz time-domain reflection signal was used to obtain information on both the spatial distribution of the coating thickness and the coating internal physical mapping. The results showed that (i) the thickness distribution of PPOS coating can be non-destructively analysed using 3D-TPI and (ii) internal physical alterations impacting the drug release kinetics were detectable by using the terahertz time-domain signal. Based on the results, the potential benefits of implementing 3D-TPI as quality control analytical tool were discussed.
Malaterre
Vincent
V
Novartis Pharma AG, Technical R&D, Basel, Switzerland. vincent.malaterre@novartis.com
Pedersen
Maireadh
M
Ogorka
Joerg
J
Gurny
Robert
R
Loggia
Nicoletta
N
Taday
Philip F
PF
D003692:Delayed-Action Preparations / Q000737:chemistry*; D021621:Imaging, Three-Dimensional / Q000379:methods; D007700:Kinetics; D009995:Osmosis; D012995:Solubility; D013499:Surface Properties; D013607:Tablets / Q000737:chemistry; D013678:Technology, Pharmaceutical; D055069:Terahertz Imaging / Q000379:methods*
D003692:Delayed-Action Preparations; D013607:Tablets