Regioselectivities in alkyne activation: synthesis of 2-(bicyclo[3.1.0]hexan-1-yl)furan derivatives by Au-catalyzed cyclization and cyclopropanation.
2-Alkynyl-1-cycloalkenecarbaldehydes, in the presence of gold catalysts, undergo aurative cyclization via the 5-exo-dig mode to form Au-carbene intermediates which react with a double bond to form the corresponding cyclopropanes.
Oh
Chang Ho
CH
Department of Chemistry, Hanyang University, Haengdang-17, Sungdong-Gu, Seoul 133-791, Korea. changho@hanyang.ac.kr
Lee
Su Jin
SJ
Lee
Ji Ho
JH
Na
Yoon Jung
YJ