[A case of osteonecrosis of the lower jaw due to bisphosphonates in a breast cancer patient with bone metastasis].
Recently, osteonecrosis of the jaw (ONJ) with bisphosphonates is frequently reported. ONJ due to bisphosphonate is an adverse event in the treatment of breast cancer with bone metastasis. We report a case of ONJ due to bisphosphonates. A 66-year-old woman was admitted to our hospital due to right advanced breast cancer with bone metastasis. She received neo-adjuvant chemotherapy consisting of paclitaxel 70 mg/m2, qw, trastuzumab 2 mg/m2, qw. After chemotherapy, we performed modified mastectomy for local control. Postoperative adjuvant chemotherapy was added with bisphosphonate for bone metastasis of breast cancer. After bisphosphonate was used 14 times, she had a pain and pus-discharge in her lower jaw. The dentists' diagnosis was ONJ. We treated her with antibiotics and local minor curettage. The inflammatory symptoms almost disappeared. In this case, the administration of bisphosphonates was thought to be a major risk factor for ONJ. We think that special precautions for ONJ should be taken in patients administered bisphosphonates for bone metastasis of breast cancer.
Kubo
Norio
N
Dept. of Surgery, Isesaki Municipal Hospital, Gunma University.
Katayama
Kazuhisa
K
Ishizaki
Akiko
A
Morinaga
Nobuhiro
N
Negishi
Takeshi
T
Kuwano
Hiroyuki
H
D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D001706:Biopsy; D001859:Bone Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000556:secondary; D001943:Breast Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D004164:Diphosphonates / Q000009:adverse effects* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007571:Jaw Diseases / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D010020:Osteonecrosis / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D014057:Tomography, X-Ray Computed
D014408:Biomarkers, Tumor; D004164:Diphosphonates