title: Kaposiform hemangioendothelioma presenting antenatally with a pericardial effusion.
abstract: We describe an infant presenting with fetal pericardial effusion requiring in utero pericardiocentesis. Important postnatal clinical features included recurrent pericardial effusion, progressive stridor, thrombocytopenia, anemia, and a mediastinal mass surrounding the heart and coronary arteries. Investigations and management consisted of repeat pericardiocentesis, platelet and red blood cell transfusions, laryngoscopy, creation of a pericardial window, and biopsy of the mediastinal mass. Diagnosis was made of Kaposiform hemangioendothelioma surrounding the base of the heart, trachea, and esophagus as well as Kasabach-Merritt phenomenon. The infant responded well to treatment with vincristine and prednisone.
authors.affiliation: Department of Pediatrics, Hospital for Sick Children, University of Toronto School of Medicine, Toronto, Canada.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Walsh
authors.forename: Manuel
authors.initials: M
authors.lastname: Carcao
authors.forename: Elena
authors.initials: E
authors.lastname: Pope
authors.forename: Kyong-Jin
authors.initials: KJ
authors.lastname: Lee
mesh_terms: D019468:Disease Management; D006390:Hemangioendothelioma / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D007223:Infant; D010490:Pericardial Effusion / Q000209:etiology*; D011241:Prednisone / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D011241:Prednisone