title: Concurrent primary hyperparathyroidism and humoral hypercalcemia of malignancy in a patient with clear cell endometrial cancer.
abstract: A 65-year-old Caucasian woman with a known history of clear cell endometrial cancer presented with hypercalcemia. Further evaluation demonstrated that the patient had primary hyperparathyroidism due to a parathyroid adenoma, as well as an increased parathyroid hormone-related peptide secondary to her malignancy. To the best of our knowledge, this is the first reported case of a female patient with concurrent primary hyperparathyroidism and humoral hypercalcemia of malignancy. This case illustrates the importance of considering a broad differential when evaluating patients with hypercalcemia. It also emphasizes the importance of recognizing the biochemical interplay between parathyroid hormone and parathyroid hormone-related peptide.
authors.affiliation: Department of Internal Medicine, Baylor University Medical Center, Dallas, TX 75246, USA. dsr51@yahoo.com
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Richey
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Welch
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D000236:Adenoma / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D000368:Aged; D002118:Calcium / Q000097:blood; D018450:Disease Progression; D016889:Endometrial Neoplasms / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D049950:Hyperparathyroidism, Primary / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D009378:Neoplasms, Multiple Primary / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D044162:Parathyroid Hormone-Related Protein / Q000097:blood*; D010282:Parathyroid Neoplasms / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D016105:Parathyroidectomy; D011183:Postoperative Complications / Q000097:blood / Q000175:diagnosis
chemical_list: D044162:Parathyroid Hormone-Related Protein; D002118:Calcium