title: [Treatment of brain injured rats through transplanting amniotic-derived mesenchymal stem cells in different ways].
abstract: OBJECTIVE
  To compare the behavioral improvement to find the best transplantation approach for treating brain injury through transplanting amniotic-derived mesenchymal stem cells into brain injured rats in different ways.
  
  
  METHODS
  Eighty brain injured Wista rats were randomly divided into a control group with brain injury alone (n=20) and a treatment group(n=60) which were further evenly divided into Group A (transplanted through the vena caudalis), Group B (transplanted through the ventriculus cerebri lateralis), and Group C (transplanted through the injured brain area). Each group was transplanted with amniotic-derived esenchymal stem cells, and their therapeutic efficacy would be evaluated through the neurological severity score (NSS).
  
  
  RESULTS
  Compared with other groups, the behaviors of Group C had markedly improved. There was statistically significant difference in the 2 groups (P<0.05). Compared with the control group, the behaviors of Group A and Group B had marked improvement. There was statistically significant difference in the 3 groups (P<0.05). However, there was no significant difference between Group A and the control group (P>0.05).
  
  
  CONCLUSIONS
  Transplanting the amniotic-derived mesenchymal stem cells into the injured brain area may be effective for brain injury in rats.
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052û Department of Tumor, First Affiliated Hospital, Henan University of Science and Technology, Luoyang Henan 471003, China.
authors.forename: Gong-ping
authors.initials: GP
authors.lastname: Wang
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.forename: Fang-xia
authors.initials: FX
authors.lastname: Guan
authors.forename: Ying
authors.initials: Y
authors.lastname: DU
authors.forename: Ke-liang
authors.initials: KL
authors.lastname: Chang
authors.forename: Lai-jun
authors.initials: LJ
authors.lastname: Song
authors.forename: Xiang
authors.initials: X
authors.lastname: Hu
authors.forename: Guang-wei
authors.initials: GW
authors.lastname: Zeng
mesh_terms: D000650:Amnion / Q000166:cytology*; D000818:Animals; D001930:Brain Injuries / Q000628:therapy*; D005260:Female; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology*; D009416:Nerve Regeneration / Q000502:physiology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar