title: Update on pathogenic mechanisms of systemic necrotizing vasculitis.
abstract: Systemic necrotizing vasculitis is rare but can have serious sequelae. Despite recent advances in cellular and molecular immunology and genetics, the causes of vasculitic syndromes remain largely undefined. Although mechanisms of blood vessel damage in systemic necrotizing vasculitis are complex, recent studies have provided significant insights.
authors.affiliation: Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, 1530 3rd Avenue South, 805 FOT, Birmingham, AL 35294, USA. Lbridges@uab.edu.
authors.forename: Maria I
authors.initials: MI
authors.lastname: Danila
authors.forename: S Louis
authors.initials: SL
authors.lastname: Bridges
mesh_terms: D000818:Animals; D000936:Antigen-Antibody Complex / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology; D001808:Blood Vessels / Q000473:pathology; D004195:Disease Models, Animal; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology; D051379:Mice; D009336:Necrosis; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D014657:Vasculitis / Q000235:genetics* / Q000276:immunology* / Q000473:pathology
chemical_list: D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D020381:Interleukin-17