title: Induction of the differentiation of human HL-60 promyelocytic leukemia cell line by succinoyl trehalose lipids.
abstract: Four analogs of succinoyl trehalose lipid-3 (STL-3)with saturated even-number or odd-number carbonchains, and unsaturated or halogenated fatty acidswere examined for their ability to inhibit the growthand induce the differentiation of HL-60 humanpromyelocytic leukemia cells. The optimalconcentration of STL-3 at which such activities wererecognized was closed to the critical micelleconcentration of STL-3. Analog of STL-3 witheven-number or odd-number carbon chain and unsaturatedfatty acids strongly inhibited growth and induced thedifferentiation of HL-60 cells, as evaluated in termsof nitroblue tetrazilium-reducing activity and theappearance of the CD36 antigen. An analog of STL-3with halogenated fatty acids significantly inhibitedproliferation but only induced the differentiation ofHL-60 cells. Our results indicate that the effects ofSTL-3 and its analogs on HL-60 cells depend on thestructure of the hydrophobic moiety of STL-3.
authors.affiliation: Tsukuba Life Science Center, RIKEN (The Institute of Physical and Chemical Research), 3-1-1 Koyadai, Tsukuba, Ibaraki, 305-0074, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sudo
authors.forename: X
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authors.lastname: Zhao
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authors.lastname: Wakamatsu
authors.forename: M
authors.initials: M
authors.lastname: Shibahara
authors.forename: N
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authors.lastname: Nomura
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authors.lastname: Nakahara
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authors.lastname: Suzuki
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authors.lastname: Kobayashi
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authors.lastname: Jin
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authors.lastname: Murata
authors.forename: K K
authors.initials: KK
authors.lastname: Yokoyama