Four new biflavonoids from Selaginella uncinata and their anti-anoxic effect.
The 60% ethanolic extract of Selaginella uncinata (Desv.) Spring possessed potent anti-anoxic effect in the anoxic PC12 cell assay. A phytochemical study of its EtOAc-soluble part led to the isolation of four new and three known biflavonoids. Their structures were established on the basis of physico-chemical properties and spectroscopic analysis. The absolute configurations of the new compounds were determined with the aid of circular dichroism (CD) spectroscopy. Compounds 4 and 5 showed potent anti-anoxic effect in the anoxic PC12 cell assay.
Zheng
Jun-Xia
JX
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
Wang
Nai-Li
NL
Liu
Hong-Wei
HW
Chen
Hai-Feng
HF
Li
Ming-Ming
MM
Wu
Li-Ying
LY
Fan
Ming
M
Yao
Xin-Sheng
XS
D000818:Animals; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology*; D000860:Hypoxia / Q000188:drug therapy; D015394:Molecular Structure; D010101:Oxygen Consumption / Q000187:drug effects; D016716:PC12 Cells; D051381:Rats; D032503:Selaginellaceae / Q000737:chemistry*
D005419:Flavonoids