Cochlear implant in children with asymptomatic congenital cytomegalovirus infection.
OBJECTIVE
To evaluate the development of speech perception and auditory skills after cochlear implantation in deaf children with asymptomatic congenital cytomegalovirus (CMV) infection diagnosed based on the presence of CMV DNA in the neonatal urine.


METHODS
A prospective study of congenital CMV infection was done between 1996 and 2003. Of 18 children diagnosed with congenital CMV infection, 2 deaf children with asymptomatic CMV infections received cochlear implantation.


RESULTS
The 2 deaf children who received cochlear implantation had delayed-onset, progressive sensorineural hearing loss on follow-up audiometric examinations administered at 29 and 39 months of age. After cochlear implantation, their Infant-Toddler Meaningful Auditory Integration Scale scores increased consistently during 36 months of follow-up; these results were similar to those of 5 congenitally deaf children without CMV infection who had cochlear implantation.


CONCLUSIONS
Cochlear implantation was effective for improving the development of speech perception and auditory skills in deaf children with asymptomatic congenital CMV infection. There was no significant difference in the development of useful auditory integration between our general pediatric cochlear implant population without CMV infection and those with asymptomatic CMV infection.
Iwasaki
Satoshi
S
Department of Otolaryngology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu City, Hamamatsu 431-3192, Japan. CBF10965@nifty.com
Nakanishi
Hiroshi
H
Misawa
Kiyoshi
K
Tanigawa
Toru
T
Mizuta
Kunihiro
K
D002675:Child, Preschool; D019929:Cochlear Implantation / Q000009:adverse effects; D003586:Cytomegalovirus Infections / Q000151:congenital* / Q000453:epidemiology; D004279:DNA, Viral / Q000652:urine; D005260:Female; D005500:Follow-Up Studies; D006310:Hearing Aids; D006319:Hearing Loss, Sensorineural / Q000209:etiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007564:Japan / Q000453:epidemiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology; D011446:Prospective Studies; D013067:Speech Perception
D004279:DNA, Viral