Imprinted hydrophilic nanospheres as drug delivery systems for 5-fluorouracil sustained release.
Molecularly imprinted hydrogel nanospheres as devices for the controlled/sustained release of 5-fluororacil in biological fluids were synthesized employing one-pot precipitation technique as the polymerization method. Methacrylic acid as a functional monomer and ethylene glycole dimethacrylate as a cross-linker were used in polymeric feed. Morphological and hydrophilic properties were determined by scanning electron microscopy and water content measurement, and recognition and selectivity properties of spherical molecularly imprinted polymers were compared with the spherical non-imprinted polymers, both in organic (acetonitrile) and water media. Finally, in vitro release studies were performed in plasma simulating fluids.
Cirillo
G
G
Dipartimento di Scienze Farmaceutiche, Universita della Calabria, Edificio Polifunzionale, Arcavacata di Rende, Italy.
Iemma
F
F
Puoci
F
F
Parisi
O I
OI
Curcio
M
M
Spizzirri
U G
UG
Picci
N
N
D000097:Acetonitriles / Q000737:chemistry; D000964:Antimetabolites, Antineoplastic / Q000138:chemical synthesis*; D003432:Cross-Linking Reagents / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000138:chemical synthesis; D016503:Drug Delivery Systems / Q000379:methods*; D019855:Ethylene Glycol / Q000737:chemistry; D005472:Fluorouracil / Q000138:chemical synthesis*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry; D008689:Methacrylates / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D054802:Molecular Imprinting / Q000379:methods*; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry; D054118:Nanospheres / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods; D011108:Polymers / Q000138:chemical synthesis; D013678:Technology, Pharmaceutical; D014498:Uracil / Q000138:chemical synthesis; D014867:Water / Q000032:analysis
D000097:Acetonitriles; D000964:Antimetabolites, Antineoplastic; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D008689:Methacrylates; D011108:Polymers; D014867:Water; C008384:methacrylic acid; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D014498:Uracil; D019855:Ethylene Glycol; D005472:Fluorouracil; C032159:acetonitrile