An initial case of suppressed restenosis with nuclear factor-kappa B decoy transfection after percutaneous coronary intervention.
BACKGROUND
Nuclear factor-kappa B (NF-kappaB) is well known for playing a pivotal role in restenosis after percutaneous coronary intervention (PCI).


RESULTS
This is the first report to demonstrate an effect of NF-kappaB decoy oligodeoxynucleotides (ODN) to prevent restenosis after PCI after a 4-year observation using a coronary computed tomography (CT) scan. We showed that the decoy treatment suppressed neointimal formation after stent implantation compared to that in the same artery.


CONCLUSIONS
Thus, for the first time, we demonstrate the clinical usefulness of the CT scan to reveal the effects of NF-kappaB decoy ODN transfer after PCI.
Suzuki
Jun-Ichi
J
Department of Advanced Clinical Science and Therapeutics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan. junichisuzuki-circ@umin.ac.jp
Tezuka
Daisuke
D
Morishita
Ryuichi
R
Isobe
Mitsuaki
M
D000279:Administration, Cutaneous; D023903:Coronary Restenosis / Q000188:drug therapy / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000627:therapeutic use; D009838:Oligodeoxyribonucleotides / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D015607:Stents; D014162:Transfection
D016328:NF-kappa B; D009838:Oligodeoxyribonucleotides