Cardiac and peripheral blood similarities in the comparison of nordiazepam and bromazepam blood concentrations.
Concomitant heart and peripheral blood determinations were performed on 40 fatal cases involving nordiazepam (20 cases) and bromazepam (20 cases). The heart blood concentration for the two drugs (588 ng/mL for nordiazepam and 802 ng/mL for bromazepam) does not differ from the corresponding peripheral blood concentration (587 ng/mL for nordiazepam and 883 ng/mL for bromazepam). The mean ratios for the heart and peripheral blood concentrations were 0.95 for nordiazepam and 0.86 for bromazepam. No postmortem redistribution was observed for these two benzodiazepines. The authors thus suggest that corresponding heart blood can be proposed in the quantitative analysis of these drugs when peripheral blood is unavailable. The present study also shows the stability of the two drugs after a year of storage.
Pos Pok
P-Rop
PR
INPS, Laboratoire de Police Scientifique de Marseille, Section Toxicologie, 97, boulevard Camille Flammarion, BP30, 13245 Marseille, France. rop-pos.pok@interieur.gouv.fr
Haddouche
Djamel
D
Mauras
Michel
M
Kuhlmann
Erika
E
Burle
Joëlle
J
Salmon
Thierry
T
Berland
Emilie
E
Coiffait
P-Emmanuel
PE
Viala
Alain
A
D000328:Adult; D014151:Anti-Anxiety Agents / Q000032:analysis* / Q000097:blood* / Q000493:pharmacokinetics; D001711:Biotransformation; D001960:Bromazepam / Q000031:analogs & derivatives / Q000032:analysis* / Q000097:blood* / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008297:Male; D009206:Myocardium / Q000737:chemistry*; D003708:Nordazepam / Q000032:analysis* / Q000097:blood* / Q000493:pharmacokinetics; D010076:Oxazepam / Q000032:analysis / Q000097:blood; D013056:Spectrophotometry, Ultraviolet
D014151:Anti-Anxiety Agents; C042089:3-hydroxybromazepam; D003708:Nordazepam; D010076:Oxazepam; D001960:Bromazepam