Severe hyperbilirubinemia in a glucose-6-phosphate dehydrogenase-deficient preterm neonate: could prematurity be the main responsible factor?
We report on a premature infant with glucose-6-phosphate dehydrogenase deficiency and severe hyperbilirubinemia. In this patient, all known potential hemolytic agents were excluded and no findings of hemolysis were observed. The crucial role of prematurity in the pathogenesis of this type of jaundice is discussed.
Costa
Simonetta
S
Division of Neonatology, Department of Pediatrics, University Hospital Agostino Gemelli, Catholic University of the Sacred Heart, Rome, Italy. imocosta@yahoo.it
De Carolis
Maria Pia
MP
De Luca
Daniele
D
Savarese
Immacolata
I
Romagnoli
Costantino
C
D000328:Adult; D000745:Anemia, Hemolytic, Congenital / Q000209:etiology / Q000235:genetics / Q000378:metabolism; D001663:Bilirubin / Q000097:blood; D005260:Female; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications* / Q000235:genetics* / Q000378:metabolism; D006400:Hematocrit; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal / Q000209:etiology* / Q000235:genetics* / Q000378:metabolism; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D011247:Pregnancy; D012720:Severity of Illness Index; D014310:Triplets
D001663:Bilirubin