Synthesis of 6,7,8-trisubstituted purines via a copper-catalyzed amidation reaction.
We report herein an efficient method for the synthesis of 6,7,8-trisubstituted purines via a copper-catalyzed amidation reaction from easily accessible starting materials. Furthermore, the resulting 6-benzylsulfanyl-substituted purine derivatives may be readily oxidized for substitution by nucleophiles to give access to 6,7,8-trisubstituted purines for biological screening purposes.
Ibrahim
Nada
N
UMR 176, Institut Curie, Bât. 110-112, Centre Universitaire, 91405 Orsay, France.
Legraverend
Michel
M
D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D011687:Purines / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
D000588:Amines; D007454:Iodides; D008024:Ligands; D011687:Purines; D003300:Copper; C073870:cuprous iodide