title: Enantioselective synthesis of silanol.
abstract: An enantioselective nucleophilic substitution reaction of achiral dialkoxysilane has been developed. The reaction proceeds with efficient stereocontrol on the silicon chirality center to give the enantioenriched silyl ether, which can be converted to the silanol without loss of enantiopurity. We have analyzed the steric course of the reaction by using DFT calculations and propose a transition state model to explain the observed enantioselectivity.
authors.affiliation: Institute for Materials Chemistry and Engineering, Kyushu University, Kasuga, Fukuoka 816-8580, Japan.
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Igawa
authors.forename: Junko
authors.initials: J
authors.lastname: Takada
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Shimono
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Tomooka