Giant cell tubulitis with immune complex deposits in a patient with lupus nephritis.
We report a case of acute tubulointerstitial nephritis with giant cell tubulitis and tubular basement membrane immune complex deposits in a patient with membranous lupus nephritis. The patient, who had no prior evidence of lupus nephritis, developed acute kidney failure and mild proteinuria after cardiac valve replacement surgery. Giant cell tubulitis with tubular basement membrane immune complex deposits has been described in 4 patients after cardiac surgery, 3 of whom received cefuroxime, suggesting the possibility of a drug hypersensitivity reaction. The present case suggests there may also be a pathogenetic role for autoimmunity in this condition.
Hodgin
Jeffrey B
JB
Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
Whelan
Joseph
J
Markowitz
Glen S
GS
Stokes
M Barry
MB
D000936:Antigen-Antibody Complex; D005260:Female; D006801:Humans; D008181:Lupus Nephritis / Q000150:complications*; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000150:complications / Q000276:immunology* / Q000473:pathology*
D000936:Antigen-Antibody Complex