title: [A study of relation between changes in serum soluble intercellular adhesion molecule and infarction volume in patients with acute cerebral infarction].
abstract: OBJECTIVE
  To characterize relation between changes in serum soluble intercellular adhesion molecule (sICAM) and infarction volume in patients with acute cerebral infarction (ACI).
  
  
  METHODS
  The levels of serum sICAM-1 of 165 patients with ACI were measured with enzyme linked immunosorbent assay (ELISA), and compared the results with that of 58 patients suffering from cerebral hemorrhage and 87 normal controls.
  
  
  RESULTS
  sICAM-1 in patients with ACI 24 hours after the onset [(4.73+/-0.26) mg/L] was higher than that in patients with cerebral hemorrhage [(2.81+/-0.18) mg/L] and normal controls [(2.64+/-0.25) mg/L, both P<0.01]. It was still higher than that in patients with cerebral hemorrhage and normal controls at the 14 days after the onset (both P<0.01). The levels of serum sICAM-1 were significantly higher in the patients with large cerebral infarction group [infarction volume was >10 cm(3), (5.14+/-0.34) mg/L] than in patients with medium [infarction volume was 4-10 cm(3), (4.47+/-0.20) mg/L] and small cerebral infarction groups [infarction volume was <4 cm(3), (4.12+/-0.28) mg/L, both P<0.01]. The levels of sICAM-1 were higher in patients complicated with infection compared with those without in 14 days (P<0.05 or P<0.01).
  
  
  CONCLUSIONS
  Serum sICAM-1 was closely related to cerebral infarction volume in patients with ACI.
authors.affiliation: Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing 400042, China. lijingcheng11@yahoo.com.cn
authors.forename: Jing-cheng
authors.initials: JC
authors.lastname: Li
authors.forename: Hua-dong
authors.initials: HD
authors.lastname: Zhou
authors.forename: Juan
authors.initials: J
authors.lastname: Deng
authors.forename: Yan-jiang
authors.initials: YJ
authors.lastname: Wang
authors.forename: Meng
authors.initials: M
authors.lastname: Zhang
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology*; D002544:Cerebral Infarction / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D018799:Intercellular Adhesion Molecule-1