title: Phase III study of cisplatin, etoposide, and concurrent chest radiation with or without consolidation docetaxel in patients with inoperable stage III non-small-cell lung cancer: the Hoosier Oncology Group and U.S. Oncology.
abstract: OBJECTIVE
  Concurrent chemoradiotherapy is standard treatment for patients with inoperable stage III non-small-cell lung cancer (NSCLC). A phase II study by the Southwest Oncology Group using consolidation docetaxel after cisplatin (P), etoposide (E), and radiation (XRT) resulted in a median survival time (MST) of 26 months. This randomized phase III trial evaluated whether consolidation docetaxel was responsible for this improved survival.
  
  
  METHODS
  Eligible patients had stage IIIA or IIIB NSCLC, baseline performance status of 0 to 1, forced expiratory volume in 1 second >or= 1 L, and less than 5% weight loss. Patients received P 50 mg/m(2) intravenously (IV) on days 1, 8, 29, and 36 and E 50 mg/m(2) IV on days 1-5 and 29-33 concurrently with chest XRT to 59.40 Gy. Patients who did not experience progression were randomly assigned to docetaxel 75 mg/m(2) IV every 21 days for three cycles versus observation. The primary end point was to compare overall survival (Kaplan-Meier analysis).
  
  
  RESULTS
  On the basis of evidence of futility, a data and safety monitoring board recommended early termination after an analysis of the initial 203 patients. Patient characteristics (n = 203) were as follows: 34% female; median age, 63 years; 39.4% stage IIIA; and 60.6% stage IIIB. One hundred forty-seven (72.4%) of 203 patients were randomly assigned to docetaxel (n = 73) or observation (n = 74). Grade 3 to 5 toxicities during docetaxel included febrile neutropenia (10.9%) and pneumonitis (9.6%); 28.8% of patients were hospitalized during docetaxel (v 8.1% in observation arm), and 5.5% died as a result of docetaxel. The MST for all patients (n = 203) was 21.7 months; MST was 21.2 months for docetaxel arm compared with 23.2 months for observation arm (P = .883).
  
  
  CONCLUSIONS
  Consolidation docetaxel after PE/XRT results in increased toxicities but does not further improve survival compared with PE/XRT alone in patients with stage III inoperable NSCLC.
authors.affiliation: Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN 46202, USA. nhanna@iupui.edu
authors.forename: Nasser
authors.initials: N
authors.lastname: Hanna
authors.forename: Marcus
authors.initials: M
authors.lastname: Neubauer
authors.forename: Constantin
authors.initials: C
authors.lastname: Yiannoutsos
authors.forename: Ronald
authors.initials: R
authors.lastname: McGarry
authors.forename: James
authors.initials: J
authors.lastname: Arseneau
authors.forename: Rafat
authors.initials: R
authors.lastname: Ansari
authors.forename: Craig
authors.initials: C
authors.lastname: Reynolds
authors.forename: Ramaswamy
authors.initials: R
authors.lastname: Govindan
authors.forename: Anton
authors.initials: A
authors.lastname: Melnyk
authors.forename: William
authors.initials: W
authors.lastname: Fisher
authors.forename: Donald
authors.initials: D
authors.lastname: Richards
authors.forename: Daniel
authors.initials: D
authors.lastname: Bruetman
authors.forename: Thomas
authors.initials: T
authors.lastname: Anderson
authors.forename: Naveed
authors.initials: N
authors.lastname: Chowhan
authors.forename: Sreenivasa
authors.initials: S
authors.lastname: Nattam
authors.forename: Prasad
authors.initials: P
authors.lastname: Mantravadi
authors.forename: Cynthia
authors.initials: C
authors.lastname: Johnson
authors.forename: Tim
authors.initials: T
authors.lastname: Breen
authors.forename: Angela
authors.initials: A
authors.lastname: White
authors.forename: Lawrence
authors.initials: L
authors.lastname: Einhorn
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D000077143:Docetaxel; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology* / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant; D043823:Taxoids / Q000008:administration & dosage; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D005047:Etoposide; D002945:Cisplatin