Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence.
Genomic studies of cannabis use disorders have been limited. The cannabinoid receptor 1 gene (CNR1) on chromosome 6q14-15 is an excellent candidate gene for cannabis dependence due to the important role of the G-protein coupled receptor encoded by this gene in the rewarding effects of Delta9-tetrahydrocannabinol. Previous studies have found equivocal evidence for an association between SNPs in CNR1 and a general vulnerability to substance use disorders. We investigate the association between 9 SNPs spanning CNR1 and cannabis dependence in 1,923 individuals. Two SNPs that were previously associated with cannabis dependence in other studies were also significant with this phenotype in our analyses [rs806368 (P = 0.05) and rs806380 (P = 0.009)]. Haplotype analyses revealed the association to be largely driven by the SNP rs806380. These results suggest a role for the cannabinoid receptor 1 gene in cannabis dependence.
Agrawal
Arpana
A
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA. arpana@wustl.edu
Wetherill
Leah
L
Dick
Danielle M
DM
Xuei
Xiaoling
X
Hinrichs
Anthony
A
Hesselbrock
Victor
V
Kramer
John
J
Nurnberger
John I
JI
Schuckit
Marc
M
Bierut
Laura J
LJ
Edenberg
Howard J
HJ
Foroud
Tatiana
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D002189:Marijuana Abuse / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D043884:Receptor, Cannabinoid, CB1 / Q000235:genetics*; D055815:Young Adult
D043884:Receptor, Cannabinoid, CB1