Urinary fatty acid-binding protein 1: an early predictive biomarker of kidney injury.
In the development of novel therapeutic strategies for kidney disease, new renal biomarkers for early detection and accurate evaluation of renal injury are urgently required for both acute kidney injury (AKI) and chronic kidney disease (CKD). Fatty acid-binding protein 1 (FABP1) is expressed in renal proximal tubule cells and shed into urine in response to hypoxia caused by decreased peritubular capillary blood flow. To clarify the role of urinary FABP1 in kidney disease, we established human FABP1 transgenic mice and evaluated the responses of FABP1 to several AKI and CKD models. Moreover, there are accumulating clinical data that urinary FABP1 can detect human AKI earlier than serum creatinine and can distinguish the risk population for AKI. Investigation with "humanized" FABP1 transgenic mice and measurement of clinical samples allowed us to develop urinary FABP1 as a new renal biomarker. Further clinical studies are necessary to confirm the potential of urinary FABP1 for clinical application.
Noiri
Eisei
E
107 Lab., Depts. of Nephrology and Endocrinology, Univ. of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, Japan 113-8655. noiri-tky@umin.ac.jp
Doi
Kent
K
Negishi
Kousuke
K
Tanaka
Tamami
T
Hamasaki
Yoshifumi
Y
Fujita
Toshiro
T
Portilla
Didier
D
Sugaya
Takeshi
T
D000208:Acute Disease; D000818:Animals; D015415:Biomarkers / Q000652:urine; D015687:Cell Hypoxia; D002908:Chronic Disease; D004195:Disease Models, Animal; D042241:Early Diagnosis; D050556:Fatty Acid-Binding Proteins / Q000652:urine*; D006801:Humans; D007511:Ischemia / Q000652:urine; D007668:Kidney / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism*; D007674:Kidney Diseases / Q000175:diagnosis* / Q000503:physiopathology / Q000652:urine; D015227:Lipid Peroxidation; D051379:Mice; D008822:Mice, Transgenic; D018384:Oxidative Stress; D011237:Predictive Value of Tests; D012079:Renal Circulation; D018805:Sepsis / Q000652:urine
D015415:Biomarkers; C493319:FABP1 protein, human; D050556:Fatty Acid-Binding Proteins