title: TNF gene polymorphisms in Graves' disease: TNF-308 A/G meta-analysis.
abstract: Autoimmune thyroid diseases (AITDs), including Graves' disease (GD) and Hashimoto thyroiditis, are associated with human MHC polymorphisms. The present study analysed two polymorphisms within tumour necrosis factor (TNF) genes (TNF-308 A/G SNP and TNFb (CT)n microsatellite) in a sample of 106 GD patients and 199 controls from the Tunisian population. The present study was designed to investigate genetic association of these polymorphisms (taken separately or considered as a haplotype) with GD development. Statistical analysis confirmed the association between the TNF-308 A allele and GD (p = 0.002), previously reported in a Tunisian familial study. The data from the present study suggest that the TNF-308 A allele plays a role in GD pathogenesis in the Tunisian population. This association was further confirmed by a meta-analysis on eight published studies (p < 0.0001). Haplotype analysis with GD revealed an associated haplotype (TNFb3-TNF-308 G haplotype: chi2 = 13.16; p = 0.0003).
authors.affiliation: Unite Cibles pour le Diagnostic et la Therapie, Centre de Biotechnologie de Sfax, Sfax, Tunisia.
authors.forename: Maha
authors.initials: M
authors.lastname: Kammoun-Krichen
authors.forename: Noura
authors.initials: N
authors.lastname: Bougacha-Elleuch
authors.forename: Ahmed
authors.initials: A
authors.lastname: Rebai
authors.forename: Mouna
authors.initials: M
authors.lastname: Mnif
authors.forename: Mohamed
authors.initials: M
authors.lastname: Abid
authors.forename: Hammadi
authors.initials: H
authors.lastname: Ayadi
mesh_terms: D000483:Alleles; D018900:Dinucleotide Repeats / Q000235:genetics / Q000276:immunology; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D006111:Graves Disease / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics / Q000276:immunology; D006801:Humans; D015810:Linkage Disequilibrium / Q000276:immunology; D008285:Major Histocompatibility Complex; D011110:Polymorphism, Genetic / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics* / Q000276:immunology*; D014416:Tunisia / Q000453:epidemiology
chemical_list: D014409:Tumor Necrosis Factor-alpha