Histidine at codon 154 of the prion protein gene is a risk factor for Nor98 scrapie in goats.
Prion protein gene (PRNP) polymorphisms are involved in modulating the appearance of atypical/Nor98 scrapie in sheep, with the alleles AHQ and AF141RQ strongly associated with occurrence of the disease. The presence of histidine at codon 154 has also been detected in Nor98-affected goats, but statistical analysis of the association between Nor98 and goat PRNP polymorphisms has not been reported previously. Here, a case-control study was carried out on eight Nor98-positive goats and 246 negative herdmates belonging to eight Italian Nor98 scrapie outbreaks. The results revealed that histidine at codon 154 is also strongly associated with the disease in goats.
Colussi
Silvia
S
Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Via Bologna 148, Torino, Italy.
Vaccari
Gabriele
G
Istituto Superiore di Sanità, Viale Regina Elena 299, Rome, Italy.
Maurella
Cristiana
C
Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Via Bologna 148, Torino, Italy.
Bona
Cristina
C
Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Via Bologna 148, Torino, Italy.
Lorenzetti
Raniero
R
Istituto Zooprofilattico Sperimentale delle Regioni Lazio Toscana, Via Appia Nuova 1411, Rome, Italy.
Troiano
Pasquale
P
Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata, Via Manfredoni 20, Foggia, Italy.
Casalinuovo
Francesco
F
Istituto Zooprofilattico Sperimentale del Mezzogiorno, Via Crotone, Catanzaro, Italy.
Di Sarno
Alessandra
A
Istituto Zooprofilattico Sperimentale del Mezzogiorno, Via Fanelli P.co dei Gerani, Caserta, Italy.
Maniaci
Maria Grazia
MG
Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Via Bologna 148, Torino, Italy.
Zuccon
Fabio
F
Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Via Bologna 148, Torino, Italy.
Nonno
Romolo
R
Istituto Superiore di Sanità, Viale Regina Elena 299, Rome, Italy.
Casalone
Cristina
C
Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Via Bologna 148, Torino, Italy.
Mazza
Maria
M
Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Via Bologna 148, Torino, Italy.
Ru
Giuseppe
G
Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Via Bologna 148, Torino, Italy.
Caramelli
Maria
M
Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Via Bologna 148, Torino, Italy.
Agrimi
Umberto
U
Istituto Superiore di Sanità, Viale Regina Elena 299, Rome, Italy.
Acutis
Pier Luigi
PL
Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Via Bologna 148, Torino, Italy.
D000818:Animals; D016022:Case-Control Studies; D003062:Codon / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015511:Goat Diseases / Q000235:genetics*; D006041:Goats; D006639:Histidine / Q000235:genetics*; D009154:Mutation; D011110:Polymorphism, Genetic; D011328:Prions / Q000235:genetics*; D012307:Risk Factors; D012608:Scrapie / Q000235:genetics*
D003062:Codon; D011328:Prions; D006639:Histidine