title: Laboratory investigation of hypercoagulability in cancer patients using rotation thrombelastography.
abstract: The goal of this study was laboratory testing for hypercoagulability in patients with solid tumors using rotation thrombelastogram (ROTEM) and correlate ROTEM parameters with routine coagulation tests. A total of 78 untreated patients with cancer were included: 28 gastrointestinal system tumors (group 1), 27 respiratory system tumors (group 2), and 23 miscellaneus group of ovarian, renal, nasopharyngeal, mesothelioma, and unknown origin (group 3). Platelet count was significantly increased in group 2 in respect to group 3 (P < 0.05) and fibrinogen level was significantly increased in group 2 in respect to group 1 (P < 0.05). There was no statistically significant difference between subgroups in respect to TEG parameters. Tumor-node-metastasis (TNM) stages of patients was not also associated with either of TEG parameters. Correlation analysis revealed significant correlation between laboratory parameters and ROTEM parameters. Fibrinogen showed the strongest correlation with MCF (r > 0.7) and CFT in all assays (INTEM, EXTEM, FIBTEM, APTEM). There were also statistically significant correlations between platelet number and other ROTEM parameters (INTEM-CFT, -MCF, EXTEM-CFT, -MCF, FIBTEM-MCF, APTEM-CFT, -MCF). In conclusions, our data demonstrates thromboelastographic signs of hypercoagulability in patients with solid tumors. ROTEM is able to identify the contribution of fibrinogen and platelets to clot strength in this patient population.
authors.affiliation: Department of Hematology, Eskisehir Osmangazi University Medical School, 26480 Eskisehir, Turkey. olga.akay@hotmail.com
authors.forename: O Meltem
authors.initials: OM
authors.lastname: Akay
authors.forename: Zeki
authors.initials: Z
authors.lastname: Ustuner
authors.forename: Zerrin
authors.initials: Z
authors.lastname: Canturk
authors.forename: Fezan Sahin
authors.initials: FS
authors.lastname: Mutlu
authors.forename: Zafer
authors.initials: Z
authors.lastname: Gulbas
mesh_terms: D000704:Analysis of Variance; D001780:Blood Coagulation Tests; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000097:blood*; D010976:Platelet Count; D012372:ROC Curve; D018709:Statistics, Nonparametric; D013916:Thrombelastography / Q000379:methods*; D019851:Thrombophilia / Q000097:blood / Q000175:diagnosis* / Q000209:etiology
chemical_list: D005340:Fibrinogen