[Involvement of serotonergic system in the pathogenesis of non-motor symptoms of Parkinson's disease].
Platelet serotonin content was investigated in 51 patients with Parkinson's disease and compared to the form and severity of non-motor symptoms - depression, anxiety and cognitive dysfunction. An average level of platelet serotonin was 166,8+/-111,1 ng/ml in parkinsonian patients that was significantly lower (p=0,027) compared to the control group (562,7+/-111,1 ng/ml). The platelet serotonin level in the peripheral blood was inversely correlated with clinical form of disease, cognitive deficits and the level of anxiety and depression.
Shutov
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Dondova
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D000368:Aged; D001008:Anxiety Disorders / Q000175:diagnosis / Q000209:etiology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications* / Q000503:physiopathology*; D012660:Semantics; D012701:Serotonin / Q000097:blood / Q000502:physiology*; D012720:Severity of Illness Index
D012701:Serotonin