title: Cost-effectiveness of vaccination against cervical cancer: a multi-regional analysis assessing the impact of vaccine characteristics and alternative vaccination scenarios.
abstract: Mathematical models provide valuable insights into the public health and economic impact of cervical cancer vaccination programmes. An in-depth economic analysis should explore the effects of different vaccine-related factors and vaccination scenarios (independent of screening practices) on health benefits and costs. In this analysis, a Markov cohort model was used to explore the impact of vaccine characteristics (e.g. cross-type protection and waning of immunity) and different vaccination scenarios (e.g. age at vaccination and multiple cohort strategies) on the cost-effectiveness results of cervical cancer vaccination programmes. The analysis was applied across different regions in the world (Chile, Finland, Ireland, Poland and Taiwan) to describe the influence of location-specific conditions. The results indicate that in all the different settings cervical cancer vaccination becomes more cost-effective with broader and sustained vaccine protection, with vaccination at younger ages, and with the inclusion of several cohorts. When other factors were varied, the cost-effectiveness of vaccination was most negatively impacted by increasing the discount rate applied to costs and health effects.
authors.affiliation: Gynecological Oncology Department, San Borja Arriarán Clinical Hospital, School of Medicine, University of Chile, Santiago, Chile.
authors.forename: Eugenio
authors.initials: E
authors.lastname: Suárez
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Smith
authors.forename: F Xavier
authors.initials: FX
authors.lastname: Bosch
authors.forename: Pekka
authors.initials: P
authors.lastname: Nieminen
authors.forename: Chien-Jen
authors.initials: CJ
authors.lastname: Chen
authors.forename: Saku
authors.initials: S
authors.lastname: Torvinen
authors.forename: Nadia
authors.initials: N
authors.lastname: Demarteau
authors.forename: Baudouin
authors.initials: B
authors.lastname: Standaert
mesh_terms: D015331:Cohort Studies; D003365:Costs and Cost Analysis; D005260:Female; D006801:Humans; D017059:Models, Econometric; D009313:National Health Programs / Q000191:economics*; D002583:Uterine Cervical Neoplasms / Q000191:economics* / Q000517:prevention & control*