title: Modular synthesis of multivalent glycoarchitectures and their unique selectin binding behavior.
abstract: Hyperbranched polyglycerols (HPGs) are ideal scaffolds for the multivalent presentation of saccharides, due to their biocompatible, carbohydrate-like properties; here, we report the conjugation of galactosesugar moieties to HPG, and the multivalent effect of these constructs on selectin binding.
authors.affiliation: Freie Universität Berlin, Institut für Chemie und Biochemie, Takustrasse 3, 14195, Berlin, Germany.
authors.forename: Ilona
authors.initials: I
authors.lastname: Papp
authors.forename: Jens
authors.initials: J
authors.lastname: Dernedde
authors.forename: Sven
authors.initials: S
authors.lastname: Enders
authors.forename: Rainer
authors.initials: R
authors.lastname: Haag
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry; D019040:E-Selectin / Q000378:metabolism; D005690:Galactose / Q000737:chemistry*; D005990:Glycerol / Q000737:chemistry*; D019041:L-Selectin / Q000378:metabolism; D019007:P-Selectin / Q000037:antagonists & inhibitors / Q000378:metabolism; D011108:Polymers / Q000737:chemistry*; D011485:Protein Binding; D019087:Selectins / Q000378:metabolism*
chemical_list: D001672:Biocompatible Materials; D019040:E-Selectin; D019007:P-Selectin; D011108:Polymers; D019087:Selectins; D019041:L-Selectin; C043941:polyglycerol; D005990:Glycerol; D005690:Galactose