title: No evidence of an association between polymorphisms in the IRAK-M gene and atopic dermatitis in a German cohort.
abstract: Atopic dermatitis (AD) is a chronic inflammatory skin disease which affects up to 10-15% of the human population in industrialized countries. A complex interaction of genetic and environmental factors is suggested to be involved in the pathogenesis of this disease. Activation of the innate immune system via toll-like receptors (TLRs) might play a role in this respect. Interleukin-1 receptor associated kinase M (IRAK-M) negatively regulates TLR signalling and inflammation. Recently, the IRAK-M gene was identified to confer linkage to asthma on chromosome 12q13-24 in a Sardinian population, and variation within the IRAK-M gene was associated with early-onset persistent asthma in Sardinian and Italian cohorts. In order to evaluate the possible role of polymorphisms in the IRAK-M gene in the pathogenesis of AD, we investigated six single nucleotide polymorphisms (SNPs) in this gene in a German AD case-control study. Unrelated AD patients (n=361) and healthy controls (n=325) were studied genetically using PCR-coupled methods. Analysis of single SNPs and haplotypes did not reveal a significant association between polymorphisms in the IRAK-M gene and AD in this cohort.
authors.affiliation: Department of Human Genetics, Ruhr-University Bochum, Bochum, Germany.
authors.forename: Jasmin
authors.initials: J
authors.lastname: Beygo
authors.forename: Qumar
authors.initials: Q
authors.lastname: Parwez
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Petrasch-Parwez
authors.forename: Jörg T
authors.initials: JT
authors.lastname: Epplen
authors.forename: Sabine
authors.initials: S
authors.lastname: Hoffjan
mesh_terms: D000293:Adolescent; D015331:Cohort Studies; D003876:Dermatitis, Atopic / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005858:Germany; D006239:Haplotypes; D006801:Humans; D053592:Interleukin-1 Receptor-Associated Kinases / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044465:White People / Q000235:genetics*
chemical_list: C507771:IRAK3 protein, human; D053592:Interleukin-1 Receptor-Associated Kinases