title: Clinical features and outcome analysis of 90 cases with brain abscess in central China.
abstract: The purpose of this study was to investigate the clinical features and outcomes of brain abscess in patients in central China. Ninety consecutive patients with brain abscess were studied retrospectively. The rate of positive bacterial culture in the present series was 12%. The outcome of superficial abscesses was better than those of abscesses in deep-seated locations (p<0.01); multiple brain abscesses led to significantly poorer outcomes than unilocated abscesses (p<0.01). There was no significant difference between the paediatric group and the adult group (p>0.05). Differences in outcomes between intrathecal injection combined with systemic administration of antibiotics vs. only venous administration could not be found (p>0.05). The clinical effectiveness of tertiary-generation cephalosporin+vancomycin+metronidazole for bacterial brain abscess was 88%. Therefore, combined antibiotics in cases with no evidence of positive culture in brain abscess are strongly recommended.
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Henan, The People's Republic of China.
authors.forename: Laijun
authors.initials: L
authors.lastname: Song
authors.forename: Fuyou
authors.initials: F
authors.lastname: Guo
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Hongwei
authors.initials: H
authors.lastname: Sun
authors.forename: Jiang
authors.initials: J
authors.lastname: Long
authors.forename: Shukai
authors.initials: S
authors.lastname: Wang
authors.forename: Jianji
authors.initials: J
authors.lastname: Bao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001921:Brain / Q000187:drug effects / Q000473:pathology; D001922:Brain Abscess / Q000188:drug therapy* / Q000382:microbiology / Q000503:physiopathology; D002511:Cephalosporins / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D002681:China; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007223:Infant; D007275:Injections, Intravenous; D007278:Injections, Spinal; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome; D014640:Vancomycin / Q000008:administration & dosage; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D008795:Metronidazole; D014640:Vancomycin