title: Preemptive therapy for cytomegalovirus disease in allogeneic stem cell transplant recipients.
abstract: Cytomegalovirus (CMV) infection causes high morbidity and mortality among allogeneic stem cell transplant recipients. Preemptive therapy with oral valganciclovir or intravenous ganciclovir has replaced universal prophylaxis. We prospectively studied 19 consecutive adult recipients of allogeneic peripheral blood stem cell transplants from May 2005 through February 2007 to analyze the safety and efficacy of preemptive therapy for the treatment of CMV infection. The antigenemia test was persistently negative in 8 patients (42%) and positive at least once in 11 (58%). Eight patients were treated with oral valganciclovir on an outpatient basis and they all became CMV negative after the first week of treatment. The other 3 patients received intravenous ganciclovir and were also CMV negative after the first week of treatment. No patient abandoned treatment, no severe secondary toxicity was noted, and there was no CMV-associated mortality.
authors.affiliation: Servicio de Hematología y Hemoterapia, Hospital Universitario Virgen del Rocío, Seville, Spain. fastydlc@hotmail.com
authors.forename: F
authors.initials: F
authors.lastname: de la Cruz-Vicente
authors.forename: P
authors.initials: P
authors.lastname: Cerezuela Martinez
authors.forename: E
authors.initials: E
authors.lastname: Gil-Espárraga
authors.forename: C
authors.initials: C
authors.lastname: Martin Aguilera
authors.forename: M
authors.initials: M
authors.lastname: Aguilar Guisado
authors.forename: R
authors.initials: R
authors.lastname: Parody Ruiz-Berdejo
authors.forename: J M
authors.initials: JM
authors.lastname: Cisneros Herreros
authors.forename: A
authors.initials: A
authors.lastname: Urbano-Ispizua
authors.forename: I
authors.initials: I
authors.lastname: Espigado Tocino
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003586:Cytomegalovirus Infections / Q000517:prevention & control*; D015774:Ganciclovir / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D006689:Hodgkin Disease / Q000601:surgery; D006801:Humans; D007275:Injections, Intravenous; D007938:Leukemia / Q000601:surgery; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000601:surgery; D011183:Postoperative Complications / Q000517:prevention & control* / Q000821:virology*; D011446:Prospective Studies; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D014184:Transplantation, Homologous / Q000009:adverse effects*; D000077562:Valganciclovir; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; D000077562:Valganciclovir; D015774:Ganciclovir