Leishmanicidal evaluation of novel synthetic chromenes.
In the present paper, twelve chromenes were synthesized by coupling of 2,2,8,8-tetramethyl-8H-pyrano[2,3-f]chroman-4-one 1 with various aryl and benzylmagnesium chlorides. The synthetic compounds were examined for in-vitro activity against Leishmania major, and some of them displayed efficient anti-leishmanial activity. Among the compounds tested, compounds 9 (4-(2-chloro-benzylidene)-2,2,8,8-tetramethyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chromene 9a and 4-(2-chloro-benzyl)-2,2,8,8-tetramethyl-2H,8H-pyrano[2,3-f]chromene 9b) were the most active with an inhibitory activity of 73.4%.
Alizadeh
Babak Heidary
BH
Iranian Research Institute of Plant Protection, Tehran, Iran.
Foroumadi
Alireza
A
Ardestani
Susan K
SK
Poorrajab
Fatemeh
F
Shafiee
Abass
A
D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D007891:Leishmania / Q000187:drug effects*; D013329:Structure-Activity Relationship
D000981:Antiprotozoal Agents; D001578:Benzopyrans