The role of the ZEB family of transcription factors in development and disease.
The ZEB family of zinc finger transcription factors are essential players during normal embryonic development. One characteristic is that they induce epithelial to mesenchymal transition (EMT), a process that reorganizes epithelial cells to become migratory mesenchymal cells. E-cadherin is a major target gene of these transcriptional repressors, and this downregulation is considered a hallmark of EMT. In recent years, the involvement of the ZEB proteins in pathological contexts has been documented as well. Mutations in ZEB encoding genes cause severe syndromic malformations and evidence is mounting that links these factors to malignant tumor progression. In this review, we describe what is currently known on the molecular pathways these transcription factors are implicated in, and we highlight their roles in development and human diseases, with a focus on tumor malignancy.
Vandewalle
C
C
Unit of Molecular and Cellular Oncology, Department for Molecular Biomedical Research, Ghent University, Technologiepark 927, VIB, 9052 Ghent, Belgium.
Van Roy
F
F
Berx
G
G
D000818:Animals; D018450:Disease Progression; D004847:Epithelial Cells / Q000502:physiology; D005786:Gene Expression Regulation; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D009024:Morphogenesis / Q000502:physiology*; D009154:Mutation; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D013577:Syndrome; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D000071799:Zinc Finger E-box-Binding Homeobox 1
D018398:Homeodomain Proteins; D020033:Protein Isoforms; D014157:Transcription Factors; C486307:ZEB1 protein, human; D000071799:Zinc Finger E-box-Binding Homeobox 1