title: HLA-B locus in Japanese patients with anti-epileptics and allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis.
abstract: BACKGROUND
  Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening severe cutaneous adverse reactions. Recently, strong associations of HLA-B*1502 and HLA-B*5801 with carbamazepine- and allopurinol-induced severe cutaneous adverse reactions were found in Han Chinese patients, respectively, but ethnic differences in the associations have been reported. The objective of this study is to clarify the involvement of HLA-B*1502 and HLA-B*5801 in Japanese SJS/TEN patients.
  
  
  METHODS
  HLA-B genotyping was performed on 58 Japanese SJS/TEN patients between July 2006 and April 2008 from multicenters in Japan.
  
  
  RESULTS
  There were no HLA-B*1502 carriers among 58 SJS/TEN patients. This patient group included seven carbamazepine-related and 11 aromatic anti-epileptic agent-related SJS/TEN patients. In addition, there were five HLA-B*5801 carriers, which included four allopurinol-related SJS/TEN patients.
  
  
  CONCLUSIONS
  While HLA-B*1502 is unlikely to be associated with carbamazepine-related or aromatic anti-epileptic agent-related SJS/TEN, HLA-B*5801 was significantly associated with allopurinol-related SJS/TEN in Japanese.
authors.affiliation: Division of Medicinal Safety Science, National Institute of Health Sciences, 1-18-11 Kamiyoga, Setagaya-ku, Tokyo. nkaniwa@nihs.go.jp
authors.forename: Nahoko
authors.initials: N
authors.lastname: Kaniwa
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Saito
authors.forename: Michiko
authors.initials: M
authors.lastname: Aihara
authors.forename: Kayoko
authors.initials: K
authors.lastname: Matsunaga
authors.forename: Masahiro
authors.initials: M
authors.lastname: Tohkin
authors.forename: Kouichi
authors.initials: K
authors.lastname: Kurose
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Sawada
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Furuya
authors.forename: Yukitoshi
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Masaaki
authors.initials: M
authors.lastname: Muramatsu
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kinoshita
authors.forename: Masamichi
authors.initials: M
authors.lastname: Abe
authors.forename: Hiroko
authors.initials: H
authors.lastname: Ikeda
authors.forename: Mariko
authors.initials: M
authors.lastname: Kashiwagi
authors.forename: Yixuan
authors.initials: Y
authors.lastname: Song
authors.forename: Mayumi
authors.initials: M
authors.lastname: Ueta
authors.forename: Chie
authors.initials: C
authors.lastname: Sotozono
authors.forename: Zenro
authors.initials: Z
authors.lastname: Ikezawa
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Hasegawa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000493:Allopurinol / Q000009:adverse effects*; D000927:Anticonvulsants / Q000009:adverse effects*; D044466:Asian People / Q000235:genetics*; D002648:Child; D005260:Female; D005838:Genotype; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced* / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics; D055815:Young Adult
chemical_list: D000927:Anticonvulsants; D015235:HLA-B Antigens; D000493:Allopurinol