title: [Preparation of fractions and characteristic of neutrophilokines complex induced by Yersinia pestis EV].
abstract: Biochemical and immunobiologic characteristics of fractions of neutrophilokines during primary and secondary immune response against plague infection are presented. Fractions were obtained using gel chromatography from neutrophilokines complex induced by vaccine strain of Yersinia pestis. It was revealed that fractions of neutrophilokines regulate IL-2 synthesis by Th1-helpers, IL-4 and IL-5 synthesis by Th2-helpers and also expression of IL-2 receptors by immunocompetent cells. Helper effect of neutrophilokines' fractions was more pronounced during secondary immune response.
authors.forename: G I
authors.initials: GI
authors.lastname: Vasil'eva
authors.forename: A K
authors.initials: AK
authors.lastname: Kiseleva
authors.forename: I A
authors.initials: IA
authors.lastname: Bespalova
authors.forename: I A
authors.initials: IA
authors.lastname: Ivanova
authors.forename: E P
authors.initials: EP
authors.lastname: Doroshenko
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Tiukavkina
mesh_terms: D000818:Animals; D002850:Chromatography, Gel; D016207:Cytokines / Q000737:chemistry / Q000276:immunology* / Q000302:isolation & purification; D007114:Immunization; D007117:Immunization, Secondary; D051379:Mice; D008970:Molecular Weight; D009504:Neutrophils / Q000276:immunology*; D010930:Plague / Q000276:immunology*; D015375:Receptors, Interleukin-2 / Q000096:biosynthesis; D013154:Spleen / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology; D015010:Yersinia pestis / Q000276:immunology*
chemical_list: D016207:Cytokines; D015375:Receptors, Interleukin-2