Effects of the chemomechanical stepping cycle on the traffic of molecular motors.
We discuss effects of the stepping kinetics of molecular motors on their traffic behavior on crowded filaments using a simple two-state chemomechanical cycle. While the general traffic behavior is quite robust with respect to the detailed kinetics of the step, a few observable parameters exhibit a strong dependence on these parameters. Most strikingly, the effective unbinding rate of the motors may both increase and decrease with increasing traffic density, depending on the details of the motor step. Likewise the run length either exhibits a strong decrease or almost no dependence on the traffic density. We compare our theoretical results with recent experimental observations on motor traffic.
Klumpp
Stefan
S
Center for Theoretical Biological Physics and Department of Physics, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093-0374, USA.
Chai
Yan
Y
Lipowsky
Reinhard
R
D001692:Biological Transport; D003599:Cytoskeleton / Q000378:metabolism; D007700:Kinetics; D008954:Models, Biological; D020409:Molecular Motor Proteins / Q000502:physiology*
D020409:Molecular Motor Proteins