Cytomegalovirus myopericarditis and hepatitis in an immunocompetent adult: successful treatment with oral valganciclovir.
Primary infection by cytomegalovirus (CMV) commonly occurs subclinically or manifested by a self-limited mononucleosis-like syndrome in immunocompetent subjects. Severe clinical pictures are uncommon. We present a case of acute myopericarditis and hepatitis in a previously healthy 32-year-old man with primary CMV infection, assessed by serology and positive pp65 antigenemia. He was successfully treated with a course of oral valganciclovir therapy, with an immediate clinical response and normalization of laboratory tests. The literature on simultaneous presentation of CMV pericarditis and hepatitis in immunocompetent hosts, as well as the role of oral valganciclovir in this clinical setting, is reviewed.
Fernández-Ruiz
Mario
M
Department of Internal Medicine, University Hospital 12 de Octubre, Madrid, Spain. mario_fdezruiz@yahoo.es
Muñoz-Codoceo
Carolina
C
López-Medrano
Francisco
F
Faré-García
Regina
R
Carbonell-Porras
Amparo
A
Garfia-Castillo
Cristina
C
Muñoz-Gómez
Raquel
R
Aguado-García
Jose María
JM
D000284:Administration, Oral; D000328:Adult; D003587:Cytomegalovirus / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000188:drug therapy*; D015774:Ganciclovir / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006525:Hepatitis, Viral, Human / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007121:Immunocompetence / Q000187:drug effects*; D008297:Male; D009205:Myocarditis / Q000175:diagnosis / Q000188:drug therapy* / Q000821:virology; D010493:Pericarditis / Q000175:diagnosis / Q000188:drug therapy* / Q000821:virology; D016896:Treatment Outcome; D000077562:Valganciclovir
D000077562:Valganciclovir; D015774:Ganciclovir