title: Expression of bcl-2 in breast cancer: correlation with clinicopathological characteristics and survival.
abstract: Breast cancer is the most common malignancy in women. It is an immensely heterogeneous disease, characterised by a broad variety of clinical development. The research in recent years has focused on finding new markers of prognosis. This study investigates the role of expression of the bcl-2 protein in breast cancer. We analysed bcl-2 expression in 57 women with primary breast carcinoma who were treated with neoadjuvant (primary) chemotherapy, followed by a surgical procedure. The bcl-2 expression was correlated with other clinicopathological characteristics of the tumour- histological grade, stage, expression of hormonal receptors, proliferation rate, and with the survival of the patients. No significant association of bcl-2 expression with either overall survival or disease free survival was found.
authors.affiliation: Charles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Department of Surgery, Czech Republic. filip.cecka@seznam.cz
authors.forename: Filip
authors.initials: F
authors.lastname: Cecka
authors.forename: Helena
authors.initials: H
authors.lastname: Hornychová
authors.forename: Bohuslav
authors.initials: B
authors.lastname: Melichar
authors.forename: Ales
authors.initials: A
authors.lastname: Ryska
authors.forename: Pavel
authors.initials: P
authors.lastname: Jandík
authors.forename: Jindriska
authors.initials: J
authors.lastname: Mergancová
authors.forename: Hana
authors.initials: H
authors.lastname: Klozová-Urminská
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D001943:Breast Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D011379:Prognosis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism; D015996:Survival Rate
chemical_list: D015415:Biomarkers; D019253:Proto-Oncogene Proteins c-bcl-2; D011960:Receptors, Estrogen