title: Hypertensive status and lipoprotein oxidation in an elderly population at high cardiovascular risk.
abstract: BACKGROUND
  In elderly individuals, hypertension is a main risk factor for cardiovascular disease and oxidative damage is increased. Our aim was to assess the relationship between the degree of in vivo low-density lipoprotein (oxLDL) oxidation and the hypertensive status in a elderly population at high cardiovascular risk.
  
  
  METHODS
  Cross-sectional study with baseline data from the PREDIMED (PREvención con DIeta MEDiterránea) trial, an intervention study directed at testing the efficacy of the Mediterranean diet on the primary prevention of cardiovascular disease. Participants were 1,130 subjects at high cardiovascular risk aged 55-80. At baseline, in vivo circulating oxLDL was measured, and stages of hypertension determined according to the USA Joint National Committee guidelines.
  
  
  RESULTS
  A positive relationship between in vivo oxLDL and systolic and diastolic blood pressure (DBP) was observed after adjusting for confounding factors (P < 0.05). OxLDL concentrations increased in a linear manner from low to high hypertensive stages (P < 0.05).
  
  
  CONCLUSIONS
  Elderly individuals at high cardiovascular risk showed higher levels of circulating oxLDL when their hypertensive status increased. This fact identifies the hypertensive elderly population as a target for antioxidant preventive measures.
authors.affiliation: Cardiovascular Risk and Nutrition Research Unit, Institut Municipal d Investigació Mèdica, Barcelona, Spain.
authors.forename: Mònica
authors.initials: M
authors.lastname: Guxens
authors.forename: Montserrat
authors.initials: M
authors.lastname: Fitó
authors.forename: Miguel-Angel
authors.initials: MA
authors.lastname: Martínez-González
authors.forename: Jordi
authors.initials: J
authors.lastname: Salas-Salvadó
authors.forename: Ramón
authors.initials: R
authors.lastname: Estruch
authors.forename: Ernest
authors.initials: E
authors.lastname: Vinyoles
authors.forename: Miguel
authors.initials: M
authors.lastname: Fiol
authors.forename: Dolores
authors.initials: D
authors.lastname: Corella
authors.forename: Fernando
authors.initials: F
authors.lastname: Arós
authors.forename: Enrique
authors.initials: E
authors.lastname: Gómez-Gracia
authors.forename: Valentina
authors.initials: V
authors.lastname: Ruiz-Gutiérrez
authors.forename: José
authors.initials: J
authors.lastname: Lapetra
authors.forename: Emili
authors.initials: E
authors.lastname: Ros
authors.forename: Joan
authors.initials: J
authors.lastname: Vila
authors.forename: María-Isabel
authors.initials: MI
authors.lastname: Covas
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003327:Coronary Disease / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D003430:Cross-Sectional Studies; D038441:Diet, Mediterranean; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D015994:Incidence; D015227:Lipid Peroxidation; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D014481:United States / Q000453:epidemiology
chemical_list: D008074:Lipoproteins