title: Pathomorphological peculiarities of trophic ulcer developed during chronic venous insufficiency of the lower limbs.
abstract: Trophic ulcers caused by chronic venous insufficiency are regarded as severe pathology. Despite numerous investigations, lots of issues need further classification. Special emphasis must be put on studying the morphologic changes, developing in tissues during the venous insufficiency. The aim of our research was to study the morphologic changes, taking place in the soft tissues of the lower third part of the calf, caused by chronic venous insufficiency. The study material was represented by the trophic ulcer, adjacent coetaneous layer and soft tissues removed from the lower third part of the calf. The investigation showed that three zones can be distinguished in case of the inflammation around the trophic ulcer. The first inner zone is located adjacent to the ulcer in multi-layer corneal epithelium. This zone is represented by acute purulent inflammation. Then there comes the middle zone, which is represented by granulative-proliferative inflammation; is the early stage of the purulent exudates organization. The outer zone is created after the granulative tissue becomes mature and is represented by fibrous hyaline connective tissue with inflammatory cellular infiltration residues in it. It is recommended to cut fibrous connective tissue scar and the adjacent soft tissues during surgery treatment. Therefore, during surgery treatment it is necessary to cut out not only fibrous connective tissue scar but the adjacent soft tissues as well.
authors.affiliation: Acad. Z.Tskhakaia West Georgia National Centre of Interventional Medicine.
authors.forename: G
authors.initials: G
authors.lastname: Arabidze
authors.forename: H
authors.initials: H
authors.lastname: Chkhaidze
mesh_terms: D002908:Chronic Disease; D005347:Fibroblasts / Q000473:pathology; D006801:Humans; D007871:Leg Ulcer / Q000209:etiology*; D014689:Venous Insufficiency / Q000150:complications* / Q000473:pathology / Q000503:physiopathology*