title: Invasive, paediatric, vaccine strains of Streptococcus pneumoniae: are there differences in clinical characteristics?
abstract: Invasive pneumococcal infections in 777 adults caused by 'invasive' (1, 7; n=187), 'paediatric' (6, 9, 14, 19, 23; n=304) and other (n=286) serogroups were compared. Infections caused by 'invasive' strains caused pneumonia more often than other serogroups and were more often isolated from younger patients without concomitant conditions and had lower case-fatality rate than 'paediatric' and other strains. The 2 latter groups differed little from each other. Infections caused by strains in the 7-valent pneumococcal conjugate vaccine differed little from infections caused by non-vaccine types indicating that widespread use of this vaccine will not markedly change the clinical characteristics of invasive pneumococcal infections in adults.
authors.affiliation: Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden. birger.trollfors@vgregion.se
authors.forename: Birger
authors.initials: B
authors.lastname: Trollfors
authors.forename: Stefan
authors.initials: S
authors.lastname: Berg
authors.forename: Erik
authors.initials: E
authors.lastname: Backhaus
authors.forename: Rune
authors.initials: R
authors.lastname: Andersson
authors.forename: Helle
authors.initials: H
authors.lastname: Bossen Konradsen
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003627:Data Interpretation, Statistical; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000382:microbiology* / Q000503:physiopathology; D022242:Pneumococcal Vaccines / Q000276:immunology; D011018:Pneumonia, Pneumococcal / Q000382:microbiology; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity*
chemical_list: D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022242:Pneumococcal Vaccines