Comparison of Bayesian and regression models in missing enzyme identification.
Computational identification of missing enzymes is important in metabolic network reconstruction. For a metabolic reaction, given a set of candidate enzymes identified by biological evidences, a powerful predictive model is necessary to predict the actual enzyme(s) catalysing the reaction. In this study, we compare Bayesian Method, which is used in previous work, with several regression models. We apply the models to known reactions in E. coli and three other bacteria. It is shown that the proposed regression models obtain favourable performance when compared with the Bayesian method.
Geng
Bo
B
Center for Biotechnology and Informatics (CBI), The Methodist Hospital Research Institute, and Department of Radiology, The Methodist Hospital, Weil Cornell Medical College, Houston, TX 77030, USA.
Zhou
Xiaobo
X
Hung
Y S
YS
Wong
Stephen
S
D001185:Artificial Intelligence; D001499:Bayes Theorem; D019295:Computational Biology; D030541:Databases, Genetic; D004798:Enzymes / Q000235:genetics*; D053858:Metabolic Networks and Pathways; D012044:Regression Analysis
D004798:Enzymes