Inflammatory demyelinating neuropathies and neuropathies associated with monoclonal gammopathies: treatment update.
This review focuses on recent data regarding inflammatory demyelinating neuropathies and neuropathies associated with monoclonal gammopathies. We describe both acute and chronic inflammatory neuropathies, and we discuss conditions ranging from mostly cell-mediated to antibody-mediated disorders. These diseases are characterized by proximal and distal sensory motor involvement. Treatments are based on immune-modulation and/or immune-suppression. Work-up sequence and therapeutical modes are discussed in the light of recently published data, with a special interest on new treatment modalities.
Steck
Andreas J
AJ
Department of Neurology, University of Basel, Basel, Switzerland. asteck@uhbs.ch
Czaplinski
Adam
A
Renaud
Susanne
S
D000818:Animals; D003449:Cryoglobulinemia / Q000150:complications / Q000473:pathology / Q000628:therapy; D003711:Demyelinating Diseases / Q000473:pathology / Q000628:therapy*; D006023:Glycoproteins / Q000276:immunology; D020275:Guillain-Barre Syndrome / Q000473:pathology / Q000628:therapy; D015417:Hereditary Sensory and Motor Neuropathy / Q000473:pathology / Q000628:therapy; D006801:Humans; D009101:Multiple Myeloma / Q000150:complications / Q000473:pathology / Q000628:therapy; D009186:Myelin Sheath / Q000276:immunology; D010026:Osteosclerosis / Q000150:complications / Q000473:pathology / Q000628:therapy; D016878:POEMS Syndrome / Q000150:complications / Q000473:pathology / Q000628:therapy; D010265:Paraproteinemias / Q000145:classification / Q000473:pathology / Q000628:therapy*; D011115:Polyneuropathies / Q000473:pathology / Q000628:therapy
D006023:Glycoproteins