title: The long-term effects of open and endovascular aneurysm repair on circulating interleukin-6.
abstract: Interleukin-6 (IL-6) is associated with abdominal aortic aneurysm (AAA) development and is an independent risk factor for cardiovascular mortality. We tested the hypothesis that aneurysm repair reduces circulating IL-6 by comparing concentrations in patients with large AAA awaiting repair (n=50) with patients having undergone open (n=34) or endovascular (n=66) repair. Only open repair was associated with a significant reduction in IL-6 (p=0.025). These results suggest that AAAs remain biologically active following endovascular repair. Aneurysm-derived IL-6 may have serious implications for cardiovascular health, and attention should be directed to modifying cardiovascular risk factors in these patients, even after successful aneurysm repair.
authors.affiliation: St George's Vascular Institute, St George's Hospital, St James Wing, London, UK.
authors.forename: J A
authors.initials: JA
authors.lastname: Dawson
authors.forename: E
authors.initials: E
authors.lastname: Choke
authors.forename: G W
authors.initials: GW
authors.lastname: Cockerill
authors.forename: I M
authors.initials: IM
authors.lastname: Loftus
authors.forename: M M
authors.initials: MM
authors.lastname: Thompson
mesh_terms: D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000097:blood* / Q000601:surgery*; D019917:Blood Vessel Prosthesis Implantation / Q000379:methods*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male
chemical_list: D015850:Interleukin-6