Inhibitory effect of macabarterin, a polyoxygenated ellagitannin from Macaranga barteri, on human neutrophil respiratory burst activity.
An ellagitannin with a 2,4-acyl group, named macabarterin (1), and a new ellagic acid glycoside, 3-O-methylellagic acid 4-O-β-d-xylopyranoside (2), were isolated from the stem bark extract of Macaranga barteri along with five known phenolic compounds, ellagic acid (3), 3-O-methylellagic acid (4), gallic acid (5), methyl gallate (6), and scopoletin (7). The structures of 1 and 2, as well as those of the known compounds, were elucidated on the basis of spectroscopic data and by comparison with reported data. Compounds 1-5 and 7 were tested for their anti-inflammatory potential in a cell-based respiratory burst assay, compound 1 being found an inhibitor of the superoxides produced in the cellular system.
Ngoumfo
Rostand Manfouo
RM
Department of Organic Chemistry, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon. monordr@yahoo.com
Ngounou
Georges Eric
GE
Tchamadeu
Chimene Victoire
CV
Qadir
Muhammad Irfan
MI
Mbazoa
Celine Djama
CD
Begum
Afshan
A
Ngninzeko
Fernande Ngounou
FN
Lontsi
David
D
Choudhary
Muhammad Iqbal
MI
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002163:Cameroon; D004610:Ellagic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D019665:Euphorbiaceae / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D047348:Hydrolyzable Tannins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects; D024301:Plant Bark / Q000737:chemistry; D016897:Respiratory Burst / Q000187:drug effects*
C534594:3'-O-methylellagic acid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D006027:Glycosides; D047348:Hydrolyzable Tannins; C013515:ellagitannin; C567995:macabarterin; D004610:Ellagic Acid