title: Fine-needle aspiration of brown tumor of bone: cytologic features with radiologic and histologic correlation.
abstract: We report the case of a 40-year-old man with tertiary hyperparathyroidism due to end stage renal disease who initially presented with acute-onset paraplegia, elevated serum parathyroid hormone, and multiple bone abnormalities, including a large extradural intraspinal mass seen by magnetic resonance imaging. In contrast with imaging features, fine-needle aspiration cytology showed numerous benign-appearing multinucleated osteoclast-type giant cells that are the characteristics of either brown tumor or benign giant cell tumor of bone. Sheets of mononuclear spindled stromal cells were also noted. A core-needle biopsy confirmed the diagnostic features of brown tumor of hyperparathyroidism.
authors.affiliation: Department of Pathology, College of Medicine, University of Illinois, Chicago, Illinois 60612, USA. spavlo2@uic.edu
authors.forename: Sasha
authors.initials: S
authors.lastname: Pavlovic
authors.forename: Tibor
authors.initials: T
authors.lastname: Valyi-Nagy
authors.forename: Jasmina
authors.initials: J
authors.lastname: Profirovic
authors.forename: Odile
authors.initials: O
authors.lastname: David
mesh_terms: D000328:Adult; D044963:Biopsy, Fine-Needle; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D003937:Diagnosis, Differential; D018212:Giant Cell Tumor of Bone / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D008297:Male; D010010:Osteoclasts / Q000473:pathology; D011859:Radiography