Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
C4-Fluorinated analogues of solamin, an antitumor acetogenin, were synthesized and investigated for their antitumor activities against 39 tumor cell lines. C4-Fluorinated solamins showed more potent growth inhibitory activity against cancer cell lines than solamin.
Kojima
Naoto
N
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
Hayashi
Hiromi
H
Suzuki
Satoshi
S
Tominaga
Hiroaki
H
Maezaki
Naoyoshi
N
Tanaka
Tetsuaki
T
Yamori
Takao
T
D054378:Acetogenins / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001558:Benzethonium / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D054378:Acetogenins; D000970:Antineoplastic Agents; D001558:Benzethonium