title: Cardiac and pulmonary late effects do not negatively influence performance status and non-relapse mortality of children surviving five yr after autologous hematopoietic cell transplantation: report from the EBMT Paediatric Diseases and Late Effects Working Parties.
abstract: The current prospective study dealt with clinical outcome associated with pulmonary and cardiac late effects of AuHCT in children with malignancies. We prospectively evaluated 58 children, utilizing pulmonary function tests and cardiac shortening fraction, performed in pre-AuHCT phase and then annually. The overall five-yr survival was 68%. The five-yr cumulative incidence of lung and cardiac function impairment in survivors was 21% in both cases. None of the patients presented with restrictive or obstructive pulmonary pathology at the last follow-up and performance status for all survivors, ranged from 90% to 100%. The cumulative incidence of non-relapse mortality was 12.6% (range 6.3-25.3%), whereas relapse mortality was 19.7% (range 11.6-33.5). In conclusion, our study shows no significant deterioration in post-AuHCT pulmonary and cardiac function and in particular, no negative impact of lung and heart late effects on performance status and non-relapse mortality.
authors.affiliation: Dipartimento Cardio-Toracico, Centro Trapianti di Midollo Osseo, Clinica Pediatrica, Ospedale San Gerardo di Monza, Università di Milano Bicocca, Italy. cornelio.uderzo@pediatriamonza.it
authors.forename: Cornelio
authors.initials: C
authors.lastname: Uderzo
authors.forename: Marta
authors.initials: M
authors.lastname: Pillon
authors.forename: Gloria
authors.initials: G
authors.lastname: Tridello
authors.forename: Giorgio
authors.initials: G
authors.lastname: Dini
authors.forename: Christian
authors.initials: C
authors.lastname: Urban
authors.forename: Paola
authors.initials: P
authors.lastname: Corti
authors.forename: Felix
authors.initials: F
authors.lastname: Zintl
authors.forename: Franca
authors.initials: F
authors.lastname: Fagioli
authors.forename: Chiara
authors.initials: C
authors.lastname: Messina
authors.forename: Amparo
authors.initials: A
authors.lastname: Verdeguer
authors.forename: Maura
authors.initials: M
authors.lastname: Faraci
authors.forename: Sara
authors.initials: S
authors.lastname: Fedeli
authors.forename: Francesco
authors.initials: F
authors.lastname: Tana
authors.forename: André
authors.initials: A
authors.lastname: Tichelli
authors.forename: Jakob
authors.initials: J
authors.lastname: Passweg
authors.forename: Attilio
authors.initials: A
authors.lastname: Rovelli
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006321:Heart / Q000502:physiology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods*; D006801:Humans; D015994:Incidence; D007223:Infant; D008168:Lung / Q000502:physiology*; D008297:Male; D010372:Pediatrics / Q000379:methods; D011446:Prospective Studies; D012129:Respiratory Function Tests; D013997:Time Factors; D016896:Treatment Outcome