A microRNA encoded in a highly conserved part of the mammalian HMGA2 gene.
The high mobility group protein HMGA2 plays an important role as a chromatin component of stem cells and as a protein causally related to the development of a variety of benign tumors (e.g., uterine leiomyomas, lipomas, and pleomorphic adenomas of the salivary glands). Herein, the existence of a highly conserved region within intron 3 of HMGA2 encoding a microRNA is described. The co-expression with HMGA2 suggests that as an intronic microRNA, this microRNA may cooperate with HMGA2 in its physiological and/or aberrant functions.
von Ahsen
Inga
I
Small Animal Clinic, University of Veterinary Medicine and Research Cluster of Excellence REBIRTH, Bischofsholer Damm 15, D-30173 Hannover, Germany.
Nimzyk
Rolf
R
Klemke
Markus
M
Bullerdiek
Jörn
J
D000818:Animals; D020029:Base Pairing; D002417:Cattle; D017124:Conserved Sequence; D004285:Dogs; D004606:Elephants; D025743:HMGA2 Protein / Q000235:genetics*; D008253:Macaca mulatta; D008322:Mammals; D051379:Mice; D035683:MicroRNAs / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D002679:Pan troglodytes; D011817:Rabbits; D051381:Rats
D025743:HMGA2 Protein; D035683:MicroRNAs