Quantitative determination of pharmaceutical drug formulations by near-infrared spectroscopic imaging.
Over the last decade Fourier transform infrared (FT-IR) and near-infrared (NIR) spectroscopic imaging with focal plane array (FPA) detectors have proved powerful techniques for the rapid visualization of samples by a combination of spectroscopic and spatial information. Using these methods, selected sample areas can be analyzed with reference to the identification and localization of chemical species by FT-IR spectroscopy in the transmission or attenuated total reflection (ATR) mode and by NIR spectroscopy in diffuse reflection with a lateral resolution in the micrometer range. The present communication focuses on the quantitative determination of the active ingredient composition of a solid drug formulation by NIR spectroscopic imaging with a focal plane array detector and the results obtained are compared to the quantitative data obtained by conservative light-fiber NIR spectroscopic diffuse reflection measurements with a single-element detector. The communication also addresses the issue of penetration depth of NIR radiation into the investigated solid material.
Kolomiets
O
O
Department of Physical Chemistry, University of Duisburg-Essen, Schuetzenbahn 70, D-45117 Essen, Germany.
Hoffmann
U
U
Geladi
P
P
Siesler
H W
HW
D001205:Ascorbic Acid / Q000032:analysis / Q000737:chemistry; D001241:Aspirin / Q000032:analysis / Q000737:chemistry; D002110:Caffeine / Q000032:analysis / Q000737:chemistry; D002482:Cellulose / Q000032:analysis / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation / Q000379:methods*; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000737:chemistry; D010604:Pharmacy / Q000379:methods*; D017550:Spectroscopy, Fourier Transform Infrared / Q000295:instrumentation / Q000379:methods*; D019265:Spectroscopy, Near-Infrared / Q000295:instrumentation / Q000379:methods*; D013213:Starch / Q000032:analysis / Q000737:chemistry
D004364:Pharmaceutical Preparations; D002110:Caffeine; D002482:Cellulose; D013213:Starch; D001205:Ascorbic Acid; D001241:Aspirin