Paraneoplastic gastro-intestinal anti-Hu syndrome in neuroblastoma.
The anti-Hu syndrome is a well-known paraneoplastic syndrome and may be rarely seen in patients with neuroblastoma. However, it is relatively unknown that anti-Hu antibodies can cause gastro-intestinal signs and symptoms. We report on a child with neuroblastoma who presented with gastro-intestinal disturbances as a result of the anti-Hu syndrome and summaries two similar case reports reported in literature. Neuroblastoma patients with gastro-intestinal disturbances, ranging from constipation to a paralytic ileus, might suffer from the gastro-intestinal anti-Hu syndrome. The causative antibodies can be determined to diagnose or exclude this syndrome, and successful treatment is possible.
Drukker
C A M
CA
Department of Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam, The Netherlands.
Heij
H A
HA
Wijnaendts
L C D
LC
Verbeke
J I M L
JI
Kaspers
G J L
GJ
D001323:Autoantibodies / Q000032:analysis / Q000276:immunology*; D002675:Child, Preschool; D051959:ELAV Proteins / Q000276:immunology*; D005767:Gastrointestinal Diseases / Q000150:complications* / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D008297:Male; D009447:Neuroblastoma / Q000150:complications* / Q000175:diagnosis; D010257:Paraneoplastic Syndromes / Q000150:complications* / Q000175:diagnosis* / Q000276:immunology
D001323:Autoantibodies; D051959:ELAV Proteins