title: Left ventricular remodelling and systolic function measurement with 64 multi-slice computed tomography versus second harmonic echocardiography in patients with coronary artery disease: a double blind study.
abstract: The present study evaluated LV volumes, ejection fraction (LVEF) and stroke volume (SV) obtained by 64-MDCT and to compare these data with those obtained by second harmonic 2D Echo, in patients referred for non-invasive coronary vessels evaluation. The most common technique in daily clinical practice used for determination of LV function is two-dimensional echocardiography (2D-TTE). Multi-detector computed tomography (MDCT) is an emerging new technique to detect coronary artery disease (CAD) and was recently proposed to assess LV function. 93 patients underwent to 64-MDCT for LV function and volumes assessment by segmental reconstruction algorithm (Argus) and compared with recent (2 months) 2D-TTE, all images were processed and interpreted by two observers blinded to the Echo and MDCT results. A close correlation between TTE and 64 MDCT was demonstrated for the ejection fraction LVEF (r=0.84), end-diastolic volume LVEDV (r=0.80) and end-systolic volume LVESV (r=0.85); acceptable correlation was recruited for stroke volume LVSV (r=0.58). Optimal results were recruited for inter-observer variability for 64-MDCT measured in 45 patients: LVESV (r=0.82, p<0.001), LVEDV (r=0.83, p<0.001), LVEF (r=0.69, p<0.002) and SV (r=0.66, p<0.001). Our results, showed that functional and temporal information contained in a coronary 64-MDCT study can be used to assess left ventricular (LV) systolic function and LV dimensions with good reproducibility and acceptable correlation respect to 2D-TTE. The combination of non-invasive coronary artery imaging and assessment of global LV function might became in the future a fast and conclusive cardiac work-up in patients with CAD.
authors.affiliation: Department of Internal Medicine and Metabolic Diseases, Cardiology Section University of Siena, S Maria alle Scotte Hospital, Siena 53100, Italy. palazzuoli2@unisi.it
authors.forename: Alberto
authors.initials: A
authors.lastname: Palazzuoli
authors.forename: Filippo
authors.initials: F
authors.lastname: Cademartiri
authors.forename: Marcel L
authors.initials: ML
authors.lastname: Geleijnse
authors.forename: Bob
authors.initials: B
authors.lastname: Meijboom
authors.forename: Francesca
authors.initials: F
authors.lastname: Pugliese
authors.forename: Osama
authors.initials: O
authors.lastname: Soliman
authors.forename: Anna
authors.initials: A
authors.lastname: Calabrò
authors.forename: Ranuccio
authors.initials: R
authors.lastname: Nuti
authors.forename: Pim
authors.initials: P
authors.lastname: de Feyter
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000150:complications* / Q000175:diagnosis*; D004311:Double-Blind Method; D004452:Echocardiography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013318:Stroke Volume; D014057:Tomography, X-Ray Computed / Q000379:methods*; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000209:etiology*; D020257:Ventricular Remodeling