title: Electrospun submicron bioactive glass fibers for bone tissue scaffold.
abstract: Submicron bioactive glass fibers 70S30C (70 mol% SiO(2), 30 mol% CaO) acting as bone tissue scaffolds were fabricated by electrospinning method. The scaffold is a hierarchical pore network that consists of interconnected fibers with macropores and mesopores. The structure, morphological characterization and mechanical properties of the submicron bioactive glass fibers were studied by XRD, EDS, FIIR, SEM, N(2) gas absorption analyses and nanoindentation. The effect of the voltage on the morphology of electrospun bioactive glass fibers was investigated. It was found that decreasing the applied voltage from 19 to 7 kV can facilitate the formation of finer fibers with fewer bead defects. The hardness and Young's modulus of submicron bioactive glass fibers were measured as 0.21 and 5.5 GPa, respectively. Comparing with other bone tissue scaffolds measured by nanoindentation, the elastic modulus of the present scaffold was relatively high and close to the bone.
authors.affiliation: Key Laboratory of Materials Physics, Institute of Solid State Physics, Chinese Academy of Sciences, Hefei, 230031, People's Republic of China.
authors.forename: H
authors.initials: H
authors.lastname: Lu
authors.forename: T
authors.initials: T
authors.lastname: Zhang
authors.forename: X P
authors.initials: XP
authors.lastname: Wang
authors.forename: Q F
authors.initials: QF
authors.lastname: Fang
mesh_terms: D001696:Biomechanical Phenomena; D018786:Bone Substitutes / Q000737:chemistry* / Q000302:isolation & purification; D055664:Electrochemical Techniques; D005898:Glass / Q000737:chemistry*; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D017550:Spectroscopy, Fourier Transform Infrared; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D018786:Bone Substitutes