A case of varicella caused by co-infection with two different genotypes of varicella-zoster virus.
We describe for the first time a case of varicella caused by co-infection with 2 genotypes of Varicella-zoster virus in a 19 month old child 3 days post-immunization with the varicella live vaccine. The presence of 2 different wild-type viruses in vesicular fluid was confirmed by amplification from single virus genomes and genotyping of single nucleotide polymorphisms (SNPs) known to distinguish the 5 different genotypes of VZV. The finding has important implications for recombination of wild type VZV.
Quinlivan
M
M
Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts, and the London School of Medicine and Dentistry, Queen Mary College, London E1 2AT, UK. mark.quinlivan@bartsandthelondon.nhs.uk
Sengupta
N
N
Breuer
J
J
D002644:Chickenpox / Q000821:virology*; D004279:DNA, Viral / Q000235:genetics; D005838:Genotype; D014645:Herpesvirus 3, Human / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D008297:Male; D020641:Polymorphism, Single Nucleotide
D004279:DNA, Viral