Shhh! Silencing by microRNA-155.
Small RNAs mediate a diverse pot-pourri of post-transcriptional silencing mechanisms, ranging from 'classical' RNA interference (RNAi), to gene repression by microRNAs (miRNAs), to maintenance of genomic stability by repeat-associated small RNAs. Here, we review recent findings on the function of miR-155, particularly its roles in mammalian innate and adaptive immunity, viral infection and oncogenesis.
Teng
Grace
G
Laboratory of Lymphocyte Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
Papavasiliou
F Nina
FN
D001483:Base Sequence; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D020868:Gene Silencing; D019288:Herpesvirus 8, Human / Q000235:genetics*; D007110:Immunity, Active / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics* / Q000276:immunology*; D017385:Sequence Homology
C524942:MIRN155 microRNA, human; D035683:MicroRNAs