[Classification and modeling of traditional Chinese medicine syndromes in patients with post-hepatitic cirrhosis by partial least-squares].
OBJECTIVE
To investigate the classification and modeling of traditional Chinese medicine (TCM) syndromes in post-hepatitic cirrhosis by partial least-squares (PLS) method, and to study the clinical application of PLS method in TCM research.


METHODS
Inclusion criteria, exclusion criteria and criteria for harvesting and inputting of the biological information such as symptoms, signs, tongue, pulse and biological parameters were established. Stepwise regression was used to analyze the clinical information, including clinical symptoms and biological parameters obtained from 278 patients with post-hepatitic cirrhosis by clinical epidemiological approach. TCM syndrome types were set up as dependent variable matrix, and the related clinical information was screened by stepwise regression as independent variable matrix. With the column maximization, all the variables were transformed into the PLS program. Mathematical models were obtained by Leave-One-Out in PLS program.


RESULTS
The determination coefficients R2 of 5 regression equations were above 0.7. The practical accuracy rates of the models in TCM patterns including liver stagnation and spleen asthenia, liver-kidney yin deficiency, spleen-kidney yang deficiency, retention of dampness-heat, and blood stasis-heat accumulation were 74.02%, 68.71%, 92.45%, 84.17% and 70.50% by PLS, respectively.


CONCLUSIONS
The utilization of clinical information can be improved by PLS, which is definitely useful in the classification and modeling of TCM complicated syndromes.
Wang
Lei
L
Institute of Liver Diseases, E-institute of Shanghai Traditional Chinese Medicine, Key Laboratory for Liver-Kidney Disease Pattern of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Su
Yue
Y
Zhang
Qin
Q
Liu
Ping
P
Su
Shi-bing
SB
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D005260:Female; D006525:Hepatitis, Viral, Human / Q000150:complications; D006801:Humans; D016018:Least-Squares Analysis; D008103:Liver Cirrhosis / Q000145:classification / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D008516:Medicine, Chinese Traditional / Q000379:methods*; D008875:Middle Aged; D008962:Models, Theoretical; D016711:Yang Deficiency / Q000175:diagnosis; D016710:Yin Deficiency / Q000175:diagnosis; D055815:Young Adult