title: FLASH: a rapid method for prototyping paper-based microfluidic devices.
abstract: This article describes FLASH (Fast Lithographic Activation of Sheets), a rapid method for laboratory prototyping of microfluidic devices in paper. Paper-based microfluidic devices are emerging as a new technology for applications in diagnostics for the developing world, where low cost and simplicity are essential. FLASH is based on photolithography, but requires only a UV lamp and a hotplate; no clean-room or special facilities are required (FLASH patterning can even be performed in sunlight if a UV lamp and hotplate are unavailable). The method provides channels in paper with dimensions as small as 200 microm in width and 70 microm in height; the height is defined by the thickness of the paper. Photomasks for patterning paper-based microfluidic devices can be printed using an ink-jet printer or photocopier, or drawn by hand using a waterproof black pen. FLASH provides a straightforward method for prototyping paper-based microfluidic devices in regions where the technological support for conventional photolithography is not available.
authors.affiliation: Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
authors.forename: Andres W
authors.initials: AW
authors.lastname: Martinez
authors.forename: Scott T
authors.initials: ST
authors.lastname: Phillips
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Wiley
authors.forename: Malancha
authors.initials: M
authors.lastname: Gupta
authors.forename: George M
authors.initials: GM
authors.lastname: Whitesides
mesh_terms: D044085:Microfluidics / Q000295:instrumentation* / Q000379:methods*; D010209:Paper; D013499:Surface Properties; D013997:Time Factors