title: How to very efficiently functionalize gold nanoparticles by "click" chemistry.
abstract: Difficulties previously encountered in the very useful "click" functionalization of gold nanoparticles (AuNPs) resulting in low yields are now overcome by using specific conditions: 1:1 water-THF medium, stoichiometric CuSO(4) and sodium ascorbate, inert atmosphere at 20 degrees C that provide quantitative "click" reactions between azidoalkylthiolate-AuNPs with various hydrophilic (PEG-containing) and hydrophobic (organic and organometallic) alkynes.
authors.affiliation: Institut des Sciences Moléculaires, UMR CNRS No. 5255, Université Bordeaux 1, 33405, Talence Cedex, France.
authors.forename: Elodie
authors.initials: E
authors.lastname: Boisselier
authors.forename: Lionel
authors.initials: L
authors.lastname: Salmon
authors.forename: Jaime
authors.initials: J
authors.lastname: Ruiz
authors.forename: Didier
authors.initials: D
authors.lastname: Astruc
mesh_terms: D000480:Alkynes / Q000737:chemistry; D001205:Ascorbic Acid / Q000737:chemistry; D019327:Copper Sulfate / Q000737:chemistry; D003500:Cyclization; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*
chemical_list: D000480:Alkynes; D006046:Gold; D019327:Copper Sulfate; D001205:Ascorbic Acid