title: Active and passive mechanisms of intracellular transport and localization in bacteria.
abstract: Spatial complexity is a hallmark of living organisms. All cells adopt specific shapes and organize their contents in such a way that makes possible fundamental tasks such as growth, metabolism, replication, and division. Although many of these tasks in bacteria have been studied extensively, only recently have we begun to understand the influence of spatial organization on cell function. Clearly, bacteria are highly organized cells where proteins do not simply diffuse in a 'cytoplasmic soup' to exert function but can also be localized to specific subcellular sites. In this review, we discuss whether such order can be achieved solely by diffusive capture mechanisms or if active intracellular transport systems are required.
authors.affiliation: Laboratoire de Chimie Bactérienne, Institut de Biologie Structurale et Microbiologie-CNRS UPR9043, 31 chemin Joseph Aiguier, 13009 Marseille, France. tmignot@ibsm.cnrs-mrs.fr
authors.forename: Tâm
authors.initials: T
authors.lastname: Mignot
authors.forename: Joshua W
authors.initials: JW
authors.lastname: Shaevitz
mesh_terms: D001419:Bacteria / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism*; D021381:Protein Transport
chemical_list: D001426:Bacterial Proteins