Antioxidant properties of natural p-terphenyl derivatives from the mushroom Thelephora ganbajun.
The antioxidant activity in vitro of three poly(phenylacetyloxy)-substituted 1,1':4',1"-terphenyl compounds from the edible mushroom Thelephora ganbajun were investigated. The IC50 values of compounds 1-3 for lipid peroxidation in rat liver homogenate were 400, 48, 54 microM, respectively. Compounds 1-3 increased superoxide dismutase (SOD) activity with EC50 values of 182, 74, 204 microM. They were also assessed on the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity with EC50 values of 49, 1233, 55 microM.
Yang
Wei-Min
WM
Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming, P.R. China.
Liu
Ji-Kai
JK
Hu
Lin
L
Dong
Ze-Jun
ZJ
Wu
Wan-Lin
WL
Chen
Zhi-He
ZH
D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D001487:Basidiomycota / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000494:pharmacology; D002681:China; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D006834:Hydrazines / Q000494:pharmacology; D007624:KB Cells / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000201:enzymology; D008297:Male; D010851:Picrates; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000187:drug effects / Q000378:metabolism; D013730:Terphenyl Compounds / Q000302:isolation & purification / Q000494:pharmacology*
D000975:Antioxidants; D001713:Biphenyl Compounds; D006834:Hydrazines; D010851:Picrates; D013730:Terphenyl Compounds; C004931:1,1-diphenyl-2-picrylhydrazyl; D013482:Superoxide Dismutase