title: Canarosine: a new guanidine alkaloid from Canavalia rosea with inhibitory activity on dopamine D1 receptors.
abstract: A new acyclic guanidine alkaloid, canarosine (1), together with five known compounds, beta-sitosterol (2), stigmasterol (3), daucosterol (4), epi-inositol 6-O-methyl ether (5), and rutin (6), were isolated from the aerial parts of Canavalia rosea. Their structures were established on the basis of their spectroscopic data. In the radioligand receptor binding assay, canarosine (1), at a concentration of 100 microg/ml, caused 91% inhibition of the dopamine D1 receptor binding with an IC50 value of 39.4 +/- 5.8 microM.
authors.affiliation: Department of Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
authors.forename: Duangpen
authors.initials: D
authors.lastname: Pattamadilok
authors.forename: Thitima
authors.initials: T
authors.lastname: Pengsuparp
authors.forename: Duangkamol
authors.initials: D
authors.lastname: Phummiratch
authors.forename: Boonsri
authors.initials: B
authors.lastname: Ongpipattanakul
authors.forename: Duangdeun
authors.initials: D
authors.lastname: Meksuriyen
authors.forename: Kazuko
authors.initials: K
authors.lastname: Kawanishi
authors.forename: Norito
authors.initials: N
authors.lastname: Kaneda
authors.forename: Rutt
authors.initials: R
authors.lastname: Suttisri
mesh_terms: D000470:Alkaloids / Q000737:chemistry*; D032449:Canavalia / Q000737:chemistry*; D019791:Guanidine / Q000031:analogs & derivatives* / Q000737:chemistry*; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry; D011869:Radioligand Assay; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors*
chemical_list: D000470:Alkaloids; D017447:Receptors, Dopamine D1; C539051:canarosine; D019791:Guanidine