title: The anatomic correlate of prosopagnosia in semantic dementia.
abstract: OBJECTIVE
  To determine the anatomic correlate of prosopagnosia in subjects with semantic dementia.
  
  
  METHODS
  We identified all subjects who had been evaluated by an experienced behavioral neurologist, met criteria for semantic dementia, and had completed a volumetric head MRI scan. In all subjects, historical records were reviewed and subjects in which the presence (n = 15) or absence (n = 12) of prosopagnosia was specifically ascertained by the neurologist were identified. Voxel-based morphometry was used to assess patterns of gray matter atrophy in subjects with and without prosopagnosia compared to a group of age and gender-matched normal controls, and compared to each other.
  
  
  RESULTS
  Compared to controls, both groups showed prominent temporal lobe volume loss. Those with prosopagnosia showed bilateral loss but with greater involvement of the right temporal lobe, while those without prosopagnosia showed predominantly left anterior temporal lobe loss. On direct comparison, subjects with prosopagnosia showed greater loss predominantly in the right amygdala, hippocampus, fusiform gyrus, and anterior temporal pole than those without prosopagnosia. No regions were involved to a greater degree in those without prosopagnosia, compared to those with prosopagnosia.
  
  
  CONCLUSIONS
  Prosopagnosia appears to be associated with volume loss of the right temporal lobe, particularly medial temporal lobe, fusiform gyrus, and anterior temporal pole, although in semantic dementia it is occurring in the context of bilateral temporal lobe volume loss.
authors.affiliation: Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. josephs.keith@mayo.edu
authors.forename: K A
authors.initials: KA
authors.lastname: Josephs
authors.forename: J L
authors.initials: JL
authors.lastname: Whitwell
authors.forename: P
authors.initials: P
authors.lastname: Vemuri
authors.forename: M L
authors.initials: ML
authors.lastname: Senjem
authors.forename: B F
authors.initials: BF
authors.lastname: Boeve
authors.forename: D S
authors.initials: DS
authors.lastname: Knopman
authors.forename: G E
authors.initials: GE
authors.lastname: Smith
authors.forename: R J
authors.initials: RJ
authors.lastname: Ivnik
authors.forename: R C
authors.initials: RC
authors.lastname: Petersen
authors.forename: C R
authors.initials: CR
authors.lastname: Jack
mesh_terms: D000368:Aged; D001931:Brain Mapping; D016022:Case-Control Studies; D003704:Dementia / Q000150:complications* / Q000473:pathology*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D020238:Prosopagnosia / Q000150:complications* / Q000473:pathology*; D012737:Sex Factors; D013702:Temporal Lobe / Q000473:pathology*