title: Smoking status over two years in patients with multiple sclerosis.
abstract: BACKGROUND
  Smoking increases the risk of multiple sclerosis (MS) and possibly disease progression. The reliability of self-reported smoking status is unknown in MS. We assessed the reliability of self-reported smoking status among participants in the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry.
  
  
  METHODS
  In 2004 and 2006, NARCOMS participants reported smoking status using Behavioral Risk Factor Surveillance Survey questions. We compared responses from 5,458 participants answering both questionnaires. We measured agreement regarding smoking status (ever/current) using a kappa coefficient, and agreement for ages of starting and quitting smoking, and number of cigarettes smoked using an intraclass correlation coefficient (ICC).
  
  
  RESULTS
  In 2004, 2,885 (53.4%) participants reported ever smoking. The kappa coefficient for ever smoking was 0.90 (95% confidence interval, CI: 0.89-0.92) and for current smoking 0.92 (95% CI: 0.90-0.94). The ICC for age at starting smoking was 0.73 (95% CI: 0.71-0.75) and for age at quitting smoking 0.90 (95% CI: 0.89-0.91). African-Americans, younger participants and those of lower socioeconomic status were less reliable. Depressed participants reported current smoking status less consistently (odds ratio: 0.51; 95% CI: 0.39-0.67).
  
  
  CONCLUSIONS
  NARCOMS participants reliably report smoking status. The impact of depression on reliability of self-reported smoking status needs re-evaluation.
authors.affiliation: Department of Medicine, University of Manitoba, Winnipeg, Man., Canada. rmarrie@hsc.mb.ca
authors.forename: Ruth Ann
authors.initials: RA
authors.lastname: Marrie
authors.forename: Gary
authors.initials: G
authors.lastname: Cutter
authors.forename: Tuula
authors.initials: T
authors.lastname: Tyry
authors.forename: Denise
authors.initials: D
authors.lastname: Campagnolo
authors.forename: Timothy
authors.initials: T
authors.lastname: Vollmer
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D015438:Health Behavior; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000453:epidemiology*; D012042:Registries / Q000706:statistics & numerical data; D012907:Smoking / Q000453:epidemiology*; D016540:Smoking Cessation / Q000706:statistics & numerical data; D011795:Surveys and Questionnaires; D055815:Young Adult