title: Risk factors for acute and chronic postoperative pain in patients with benign and malignant renal disease after nephrectomy.
abstract: OBJECTIVE
  This longitudinal study was performed in order to analyze the incidence of and perioperative risk factors for the development of chronic postsurgical pain (CPSP) in patients after nephrectomy.
  
  
  METHODS
  For baseline data acquisition, valid instruments were used for scoring sociodemographic, psychological, psychosocial, pain, pain treatment, and comorbidity factors: the Mainz Pain Staging System (MPSS) for pain chronicity, the Chronic Pain Grading Questionnaire (CPGQ), the Neuropathic Pain Scale (NPS), the Hospital Anxiety and Depression Scale (HADS), the Short Form 12 (SF-12) for health-related quality of life, the Habitual Well-Being Questionnaire (HWBQ), the Symptom Check List (SCL-8) for detecting psychosomatic dysfunction, and the Weighted Illness Check List (WICL) for evaluation of comorbidities and their impact on activities of daily living. Pain intensities were recorded over the first 6 postoperative days after nephrectomy. A sample of 35 patients was followed up for 3 and 6 months.
  
  
  RESULTS
  Patients with more intense postoperative pain during the first 6 days had significantly higher preoperative anxiety scores. The incidence of CPSP 3 and 6 months after nephrectomy was 28.6% and 8.6%, respectively. Preoperatively increased anxiety scores, reduced physical health-related quality of life (SF-12), multiple comorbid conditions, and increased comorbidity-related disability were significantly associated with the occurrence of CPSP after 3 months. These patients also reported more severe pain during the first week after surgery. Preoperative "current pain intensity" was significantly increased in CPSP patients.
  
  
  CONCLUSIONS
  Our results demonstrate a multifactorial development of CPSP. This process may contribute not only to the occurrence of chronic postsurgical pain but also to the biopsychosocial impairment in these patients as often seen in other chronic pain populations.
authors.affiliation: Department of Anesthesiology, University of Cologne, Kerpenerstr. 62, 50924 Cologne, Germany. hans.gerbershagen@uk-koeln.de
authors.forename: Hans J
authors.initials: HJ
authors.lastname: Gerbershagen
authors.forename: Oguzhan
authors.initials: O
authors.lastname: Dagtekin
authors.forename: Tim
authors.initials: T
authors.lastname: Rothe
authors.forename: Axel
authors.initials: A
authors.lastname: Heidenreich
authors.forename: Kathrin
authors.initials: K
authors.lastname: Gerbershagen
authors.forename: Rainer
authors.initials: R
authors.lastname: Sabatowski
authors.forename: Frank
authors.initials: F
authors.lastname: Petzke
authors.forename: Enver
authors.initials: E
authors.lastname: Ozgür
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D015360:Analgesia, Epidural; D001007:Anxiety / Q000523:psychology; D002908:Chronic Disease; D003863:Depression / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007674:Kidney Diseases / Q000150:complications* / Q000601:surgery*; D007680:Kidney Neoplasms / Q000150:complications* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy / Q000009:adverse effects*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000453:epidemiology* / Q000628:therapy; D010523:Peripheral Nervous System Diseases / Q000150:complications / Q000453:epidemiology; D011446:Prospective Studies; D012307:Risk Factors; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires