title: Lipids on the move: simulations of membrane pores, domains, stalks and curves.
abstract: In this review we describe the state-of-the-art of computer simulation studies of lipid membranes. We focus on collective lipid-lipid and lipid-protein interactions that trigger deformations of the natural lamellar membrane state, showing that many important biological processes including self-aggregation of membrane components into domains, the formation of non-lamellar phases, and membrane poration and curving, are now amenable to detailed simulation studies.
authors.affiliation: Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands. s.j.marrink@rug.nl
authors.forename: Siewert J
authors.initials: SJ
authors.lastname: Marrink
authors.forename: Alex H
authors.initials: AH
authors.lastname: de Vries
authors.forename: D Peter
authors.initials: DP
authors.lastname: Tieleman
mesh_terms: D000818:Animals; D022082:Cellular Structures / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D003198:Computer Simulation; D004734:Energy Metabolism; D006801:Humans; D008560:Membrane Fluidity; D008563:Membrane Lipids / Q000378:metabolism* / Q000502:physiology*; D021962:Membrane Microdomains / Q000378:metabolism* / Q000502:physiology; D008954:Models, Biological; D008958:Models, Molecular
chemical_list: D008563:Membrane Lipids