title: Enhanced dissolution of ibuprofen using solid dispersion with poloxamer 407.
abstract: To improve its dissolution, ibuprofen solid dispersions (SDs) were prepared, characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FTIR), and evaluated for solubility, and in-vitro ibuprofen release. Loss of individual surface properties during melting and re-solidification as revealed by SEM micrographs indicated the formation of effective SDs. Absence or shifting towards the lower melting temperature of the drug peak in SDs and physical mixtures in DSC study indicated the possibilities of drug-polymer interactions. FTIR spectra showed the presence of drug crystalline in SDs. The effect of improved dissolution on the oral absorption of ibuprofen in rats was also studied. Quicker release of ibuprofen from SDs in rat intestine resulted in a significant increase in AUC and C(max), and a significant decrease in T(max) over pure ibuprofen. Comparison of the enhanced solubility, dissolution, AUC, and C(max) of ibuprofen from different poloxamers suggested that the preparation of ibuprofen SDs using P 407 as a meltable hydrophilic polymer carrier could be a promising approach to improve its solubility, dissolution and absorption rate.
authors.affiliation: College of Pharmacy, Yeungnam University, Gyongsan 712-749, Korea.
authors.forename: Madhuri
authors.initials: M
authors.lastname: Newa
authors.forename: Krishna Hari
authors.initials: KH
authors.lastname: Bhandari
authors.forename: Dong Hoon
authors.initials: DH
authors.lastname: Oh
authors.forename: Young Ran
authors.initials: YR
authors.lastname: Kim
authors.forename: Joon Ho
authors.initials: JH
authors.lastname: Sung
authors.forename: Jong Oh
authors.initials: JO
authors.lastname: Kim
authors.forename: Jong Soo
authors.initials: JS
authors.lastname: Woo
authors.forename: Han Gon
authors.initials: HG
authors.lastname: Choi
authors.forename: Chul Soon
authors.initials: CS
authors.lastname: Yong
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D005079:Excipients; D007052:Ibuprofen / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D008297:Male; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D020442:Poloxamer / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005079:Excipients; D020442:Poloxamer; D007052:Ibuprofen