Cardiac and pulmonary late effects do not negatively influence performance status and non-relapse mortality of children surviving five yr after autologous hematopoietic cell transplantation: report from the EBMT Paediatric Diseases and Late Effects Working Parties.
The current prospective study dealt with clinical outcome associated with pulmonary and cardiac late effects of AuHCT in children with malignancies. We prospectively evaluated 58 children, utilizing pulmonary function tests and cardiac shortening fraction, performed in pre-AuHCT phase and then annually. The overall five-yr survival was 68%. The five-yr cumulative incidence of lung and cardiac function impairment in survivors was 21% in both cases. None of the patients presented with restrictive or obstructive pulmonary pathology at the last follow-up and performance status for all survivors, ranged from 90% to 100%. The cumulative incidence of non-relapse mortality was 12.6% (range 6.3-25.3%), whereas relapse mortality was 19.7% (range 11.6-33.5). In conclusion, our study shows no significant deterioration in post-AuHCT pulmonary and cardiac function and in particular, no negative impact of lung and heart late effects on performance status and non-relapse mortality.
Uderzo
Cornelio
C
Dipartimento Cardio-Toracico, Centro Trapianti di Midollo Osseo, Clinica Pediatrica, Ospedale San Gerardo di Monza, Università di Milano Bicocca, Italy. cornelio.uderzo@pediatriamonza.it
Pillon
Marta
M
Tridello
Gloria
G
Dini
Giorgio
G
Urban
Christian
C
Corti
Paola
P
Zintl
Felix
F
Fagioli
Franca
F
Messina
Chiara
C
Verdeguer
Amparo
A
Faraci
Maura
M
Fedeli
Sara
S
Tana
Francesco
F
Tichelli
André
A
Passweg
Jakob
J
Rovelli
Attilio
A
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006321:Heart / Q000502:physiology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods*; D006801:Humans; D015994:Incidence; D007223:Infant; D008168:Lung / Q000502:physiology*; D008297:Male; D010372:Pediatrics / Q000379:methods; D011446:Prospective Studies; D012129:Respiratory Function Tests; D013997:Time Factors; D016896:Treatment Outcome