[Study on oral Candida albicans apoptosis in vitro].
OBJECTIVE
Candida albicans is one of the main opportunistic pathogen for human , the aim of this study is to investigate the phenomena of apoptosis in oral Candida albicans induced by acetic acid.


METHODS
The Candida albicans of clinical strains were induced to apoptosis by using a weak acid acetic acid.The apoptosis was detected by flow cytometry and TEM. The data were processed for Chi-square test using SPSS11.5 software package.


RESULTS
Oral Candida albicans had classic apoptosis when induced by proper concentration of acetic acid, and different concentrations of acetic acid had variable ability of inducing apoptosis of Candida albicans.


CONCLUSIONS
Apoptosis can be detected in clinical strains of Candida albicans, the mechanism of apoptosis needs further research for the purpose of developing new antifungal drugs. Supported by National Natural Science Foundation of China(Grant No.30400498) and 2007 National College Student Innovative Planning Project.
Yang
Cheng-Zhe
CZ
College of Stomatology, Shandong University, Jinan 250012, Shandong Province, China. yangchengzhe19@163.com
Gong
Wei-Yu
WY
Lu
Jing-Ting
JT
Zhang
Jie-Ni
JN
Zhu
Xiu-Juan
XJ
Qi
Qing-Guo
QG
D019342:Acetic Acid; D000935:Antifungal Agents; D017209:Apoptosis; D002176:Candida albicans / Q000472:pathogenicity*; D002177:Candidiasis; D006801:Humans; D066298:In Vitro Techniques
D000935:Antifungal Agents; D019342:Acetic Acid