Modular synthesis of multivalent glycoarchitectures and their unique selectin binding behavior.
Hyperbranched polyglycerols (HPGs) are ideal scaffolds for the multivalent presentation of saccharides, due to their biocompatible, carbohydrate-like properties; here, we report the conjugation of galactosesugar moieties to HPG, and the multivalent effect of these constructs on selectin binding.
Papp
Ilona
I
Freie Universität Berlin, Institut für Chemie und Biochemie, Takustrasse 3, 14195, Berlin, Germany.
Dernedde
Jens
J
Enders
Sven
S
Haag
Rainer
R
D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry; D019040:E-Selectin / Q000378:metabolism; D005690:Galactose / Q000737:chemistry*; D005990:Glycerol / Q000737:chemistry*; D019041:L-Selectin / Q000378:metabolism; D019007:P-Selectin / Q000037:antagonists & inhibitors / Q000378:metabolism; D011108:Polymers / Q000737:chemistry*; D011485:Protein Binding; D019087:Selectins / Q000378:metabolism*
D001672:Biocompatible Materials; D019040:E-Selectin; D019007:P-Selectin; D011108:Polymers; D019087:Selectins; D019041:L-Selectin; C043941:polyglycerol; D005990:Glycerol; D005690:Galactose