A renaissance in understanding the multiple and diverse functions of granzymes?
In this issue of Immunity, Metkar et al. (2008) present evidence that granzyme A plays a role in inflammatory signaling and that contrary to previous studies, it is incapable of inducing target cell death. The work challenges us to reconsider the broader biological roles of all the granzymes.
Trapani
Joseph A
JA
Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne, Victoria 3002, Australia. joe.trapani@petermac.org
Bird
Phillip I
PI
D000818:Animals; D016923:Cell Death; D016207:Cytokines / Q000276:immunology* / Q000378:metabolism; D053804:Granzymes / Q000172:deficiency / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D054353:Perforin / Q000378:metabolism*; D013379:Substrate Specificity; D013602:T-Lymphocytes, Cytotoxic / Q000201:enzymology / Q000276:immunology*
D016207:Cytokines; D054353:Perforin; D053804:Granzymes