Peptides and peptide mimics as modulators of apoptotic pathways.
Programmed cell death is an important and stringently controlled process. Aberrancies in its control mechanisms can lead to disease; overactive apoptosis can cause neurodegenerative disorders, whereas deficient apoptotic activity can lead to cancer. Therefore, controlling apoptotic pathways with peptides is showing increasing promise as a strategy in drug development.Programmed cell death or apoptosis is a noninvasive and strictly regulated cellular process required for organism development and tissue homeostasis. Deficiencies in apoptotic pathways are the source of many diseases such as cancer, neurodegenerative and autoimmune diseases, and disorders related to an inappropriate loss of cells such as heart failure, stroke, and liver injury. Validation of the various points of intervention as targets for drug development has been the subject of a vast number of studies. Peptides are essential tools for drug discovery, as well as preclinical and pharmaceutical drug development.
Orzáez
Mar
M
Department of Medicinal Chemistry, Centro de Investigación Príncipe Felipe, Valencia, Spain.
Gortat
Anna
A
Mondragón
Laura
L
Pérez-Payá
Enrique
E
D017209:Apoptosis / Q000187:drug effects*; D020169:Caspases / Q000378:metabolism; D018360:Crystallography, X-Ray; D006801:Humans; D018716:Molecular Mimicry; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D011487:Protein Conformation
D010455:Peptides; D020169:Caspases