title: Effect of intraarticular injection of autologous adipose-derived mesenchymal stem and regenerative cells on clinical signs of chronic osteoarthritis of the elbow joint in dogs.
abstract: Autologous adipose-derived mesenchymal stem cell (AD-MSC) therapy involves harvesting fat from the patient, isolating the stem and regenerative cells, and administering the cells back to the patient. Autologous AD-MSC therapy in veterinary regenerative medicine has been commercially available since 2003. Previously reported results from a blinded, controlled trial in dogs with chronic osteoarthritis of the coxofemoral (hip) joint demonstrated efficacy of a single intraarticular injection of autologous AD-MSC therapy. The primary objective of the current study was to evaluate the effectiveness of this therapy in dogs with chronic osteoarthritis of the humeroradial (elbow) joints and to determine the duration of effect. Fourteen dogs were recruited. Veterinarians assessed each dog for lameness, pain on manipulation, range of motion, and functional disability using a numeric rating scale at baseline and specified intervals up to 180 days after treatment. Statistically significant improvement in outcome measures was demonstrated.
authors.affiliation: Vet-Stem Inc., 12860 Danielson Court, Poway, CA 92064, USA.
authors.forename: Linda L
authors.initials: LL
authors.lastname: Black
authors.forename: James
authors.initials: J
authors.lastname: Gaynor
authors.forename: Cheryl
authors.initials: C
authors.lastname: Adams
authors.forename: Sarit
authors.initials: S
authors.lastname: Dhupa
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Sams
authors.forename: Robert
authors.initials: R
authors.lastname: Taylor
authors.forename: Susan
authors.initials: S
authors.lastname: Harman
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Gingerich
authors.forename: Robert
authors.initials: R
authors.lastname: Harman
mesh_terms: D000818:Animals; D002908:Chronic Disease; D004283:Dog Diseases / Q000628:therapy*; D004285:Dogs; D004551:Elbow Joint / Q000473:pathology*; D005260:Female; D007270:Injections, Intra-Articular / Q000379:methods / Q000662:veterinary; D007794:Lameness, Animal / Q000209:etiology / Q000628:therapy; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods / Q000662:veterinary*; D010003:Osteoarthritis / Q000628:therapy / Q000662:veterinary*; D016059:Range of Motion, Articular; D013997:Time Factors; D014182:Transplantation, Autologous / Q000379:methods / Q000662:veterinary; D016896:Treatment Outcome