[Distribution of genetic markers in offsprings of irradiated individuals].
For the estimation of radiation exposure on genetic processes in Mayak PA population we studied the distribution of a number of genetic markers in offsprings of Mayak PA workers depending on radiation (preconceptive and antenatal chronic exteral gamma-radiation) and non-radiation (age-sex characteristics of children and age characteristics of parents to the moment of conception) factors. Relatively unfavorable changes in distribution of genotypes and genes of haptoglobin genetic system in offsprings, whose parents (one or both) were exposed to external gamma-radiation in preconceptive cumulative dose of more than 200 cGy were detected. The most obvious reason of such changes may consist in directed gametic selection (Hp2 allele versus Hp1 allele) which turns out in abnormalities of segregation of Hp2-1 heterozygote that have both alleles. Effect of antenatal exposure on distribution of studied genetic markers in offspring of exposed population in studied dose range were not found. Homotypic changes in distribution of ABO bood groups and alleles in offspring of exposed and unexposed individuals depending on age characteristics of parents (middle age and age differences of both parents) for the moment of conception were also detected.
Tel'nov
V I
VI
D000017:ABO Blood-Group System / Q000235:genetics*; D000328:Adult; D000367:Age Factors; D000483:Alleles; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005720:Gamma Rays / Q000009:adverse effects*; D005819:Genetic Markers / Q000528:radiation effects; D005838:Genotype; D006242:Haptoglobins / Q000235:genetics* / Q000528:radiation effects; D006801:Humans; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects*; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D018812:Paternal Exposure / Q000009:adverse effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000209:etiology / Q000235:genetics*; D012426:Russia; D055815:Young Adult
D000017:ABO Blood-Group System; D005819:Genetic Markers; D006242:Haptoglobins