title: Management of invasive Candida infections in non-neutropenic critically ill patients: from prophylaxis to early therapy.
abstract: Echinocandins are the treatment of choice for patients with severe forms of candidaemia, including neutropenic patients and those episodes presenting with shock. There is little distinction between the three available echinocandins (caspofungin, anidulafungin and micafungin), but there is more clinical experience with caspofungin. Identifying patients who will benefit from early antifungal therapy using clinical tools such as the 'Candida Score' is an interesting strategy that may reduce the high mortality in critically ill patients with invasive fungal infections.
authors.affiliation: Intensive Care Unit, Hospital Universitario Virgen del Rocio, Sevilla, Spain. jose.garnacho.sspa@juntadeandalucia.es
authors.forename: José
authors.initials: J
authors.lastname: Garnacho-Montero
authors.forename: Ana
authors.initials: A
authors.lastname: Díaz-Martín
authors.forename: Aurelio
authors.initials: A
authors.lastname: Cayuela-Dominguez
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D002177:Candidiasis / Q000188:drug therapy* / Q000517:prevention & control*; D018890:Chemoprevention / Q000379:methods*; D016638:Critical Illness; D054714:Echinocandins / Q000627:therapeutic use*; D006801:Humans
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins