Significantly skewed memory CD8+ T cell subsets in HIV-1 infected infants during the first year of life.
HIV-1 infection causes a severe T cell compromise; however, little is known about changes in naive, memory, effector and senescent T cell subsets during the first year of life. T cell subsets were studied over the first year of life in blood from 3 infant cohorts: untreated HIV-infected, HIV-exposed but uninfected, and HIV-unexposed. In HIV-infected infants, the frequency of CCR7(+)CD45RA(+) naive CD8(+) T cells was significantly decreased, while the frequency of CCR7(-)CD45RA(-) effector memory CD8(+) T cells was increased, compared with the control cohorts. A larger population of CD8(+) T cells in HIV-infected infants displayed a phenotype consistent with senescence. Differences in CD4(+) T cell subset frequencies were less pronounced, and no significant differences were observed between exposed and unexposed HIV-uninfected infants. We concluded that the proportion of naive, memory, effector and senescent CD8(+) T cells during the first year of life is significantly altered by HIV-1 infection.
Mansoor
Nazma
N
South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine and School of Child and Adolescent Health, University of Cape Town, Anzio Road, Observatory, 7925, South Africa.
Abel
Brian
B
Scriba
Thomas J
TJ
Hughes
Jane
J
de Kock
Marwou
M
Tameris
Michele
M
Mlenjeni
Sylvia
S
Denation
Lea
L
Little
Francesca
F
Gelderbloem
Sebastian
S
Hawkridge
Anthony
A
Boom
W Henry
WH
Kaplan
Gilla
G
Hussey
Gregory D
GD
Hanekom
Willem A
WA
D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000821:virology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology; D002452:Cell Count; D002454:Cell Differentiation; D005260:Female; D005434:Flow Cytometry; D015658:HIV Infections / Q000276:immunology* / Q000635:transmission; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D010641:Phenotype; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology*