title: Targeting reward-relevant nicotinic receptors in the discovery of novel pharmacotherapeutic agents to treat tobacco dependence.
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536-0082, USA. ldwoskin@email.uky.edu
authors.forename: Linda P
authors.initials: LP
authors.lastname: Dwoskin
authors.forename: Marharyta
authors.initials: M
authors.lastname: Pivavarchyk
authors.forename: B Matthew
authors.initials: BM
authors.lastname: Joyce
authors.forename: Nichole M
authors.initials: NM
authors.lastname: Neugebauer
authors.forename: Guangrong
authors.initials: G
authors.lastname: Zheng
authors.forename: Zhenfa
authors.initials: Z
authors.lastname: Zhang
authors.forename: Michael T
authors.initials: MT
authors.lastname: Bardo
authors.forename: Peter A
authors.initials: PA
authors.lastname: Crooks
mesh_terms: D000818:Animals; D001552:Benzazepines / Q000009:adverse effects / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D016642:Bupropion / Q000009:adverse effects / Q000627:therapeutic use; D004298:Dopamine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D015507:Drugs, Investigational / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D009538:Nicotine / Q000009:adverse effects / Q000627:therapeutic use; D018733:Nicotinic Antagonists / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D010847:Picolines / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D000644:Quaternary Ammonium Compounds / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D011810:Quinoxalines / Q000009:adverse effects / Q000627:therapeutic use; D051381:Rats; D011916:Rats, Inbred F344; D017207:Rats, Sprague-Dawley; D011978:Receptors, Nicotinic / Q000187:drug effects* / Q000502:physiology; D012201:Reward; D016540:Smoking Cessation / Q000523:psychology*; D013329:Structure-Activity Relationship; D014029:Tobacco Use Disorder / Q000503:physiopathology / Q000534:rehabilitation*; D000068580:Varenicline; D017557:Ventral Tegmental Area / Q000187:drug effects / Q000502:physiology; D064569:alpha7 Nicotinic Acetylcholine Receptor
chemical_list: D001552:Benzazepines; C579165:Chrna7 protein, rat; D015507:Drugs, Investigational; C513964:N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide; D018733:Nicotinic Antagonists; D010847:Picolines; D000644:Quaternary Ammonium Compounds; D011810:Quinoxalines; D011978:Receptors, Nicotinic; D064569:alpha7 Nicotinic Acetylcholine Receptor; D016642:Bupropion; D009538:Nicotine; D004298:Dopamine; D000068580:Varenicline