title: [Isolation and characterization of the anti-HIV active component from Eucommia ulmoides].
abstract: OBJECTIVE
  To investigate the anti-HIV effects of Eucommia ulmoides Oliver, so as to provide experimental basis for searching a new efficacious drug for treatment of AIDS.
  
  
  METHODS
  Using phytochemistry to isolate compounds from Eucommia ulmoides Oliver, the inhibitory activity of Samples on the HIV gp41 six-helix bundle formation was determined by a modified sandwich ELISA and PAGE.
  
  
  RESULTS
  The Samples from Eucommia ulmoides Oliver had potent inhibitory activity on the HIV gp41 six-helix bundle formation.
  
  
  CONCLUSIONS
  Eucommia uloides Oliver can inhibit HIV by targeting HIV gp41.
authors.affiliation: School of Pharmacy, Southern Medical University, Guangzhou 510515, China. lynnlv@fimmu.com
authors.forename: Lin
authors.initials: L
authors.lastname: Lv
authors.forename: Yan-Rong
authors.initials: YR
authors.lastname: Sun
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.forename: Shu-Wen
authors.initials: SW
authors.lastname: Liu
authors.forename: Jin-Jun
authors.initials: JJ
authors.lastname: Rao
authors.forename: Shu-Guang
authors.initials: SG
authors.lastname: Wu
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification* / Q000494:pharmacology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D031283:Eucommiaceae / Q000737:chemistry*; D015700:HIV Envelope Protein gp41 / Q000187:drug effects*; D023581:HIV Fusion Inhibitors / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D019380:Anti-HIV Agents; D004365:Drugs, Chinese Herbal; D015700:HIV Envelope Protein gp41; D023581:HIV Fusion Inhibitors