title: Acute respiratory failure involving an R variant of Mycobacterium abscessus.
abstract: We report the case of a cystic fibrosis patient colonized with a smooth-morphotype form of Mycobacterium abscessus who developed acute respiratory failure with the emergence of an isogenic rough (R) variant while he was recovering from peritonitis-induced shock. This report emphasizes the role of R forms in severe M. abscessus infections.
authors.affiliation: Laboratoire de Microbiologie, AP-HP, Hôpital Raymond Poincaré et Hôpital Ambroise Paré, and Université de Versailles-Saint-Quentin-en-Yvelines, EA3647, Garches, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Catherinot
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Roux
authors.forename: Edouard
authors.initials: E
authors.lastname: Macheras
authors.forename: Dominique
authors.initials: D
authors.lastname: Hubert
authors.forename: Moussa
authors.initials: M
authors.lastname: Matmar
authors.forename: Luc
authors.initials: L
authors.lastname: Dannhoffer
authors.forename: Thierry
authors.initials: T
authors.lastname: Chinet
authors.forename: Philippe
authors.initials: P
authors.lastname: Morand
authors.forename: Claire
authors.initials: C
authors.lastname: Poyart
authors.forename: Beate
authors.initials: B
authors.lastname: Heym
authors.forename: Martin
authors.initials: M
authors.lastname: Rottman
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Gaillard
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Herrmann
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003550:Cystic Fibrosis / Q000150:complications*; D016172:DNA Fingerprinting; D004269:DNA, Bacterial / Q000235:genetics; D006801:Humans; D008297:Male; D009161:Mycobacterium / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D009164:Mycobacterium Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D010538:Peritonitis / Q000150:complications*; D013902:Radiography, Thoracic; D019105:Random Amplified Polymorphic DNA Technique; D012131:Respiratory Insufficiency / Q000209:etiology* / Q000628:therapy
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial