title: Multi-stage analysis of gene expression and transcription regulation in C57/B6 mouse liver development.
abstract: The liver performs a number of essential functions for life. The development of such a complex organ relies on finely regulated gene expression profiles which change over time in the development and determine the phenotype and function of the liver. We used high-density oligonucleotide microarrays to study the gene expression and transcription regulation at 14 time points across the C57/B6 mouse liver development, which include E11.5 (embryonic day 11.5), E12.5, E13.5, E14.5, E15.5, E16.5, E17.5, E18.5, Day0 (the day of birth), Day3, Day7, Day14, Day21, and normal adult liver. With these data, we made a comprehensive analysis on gene expression patterns, functional preferences and transcriptional regulations during the liver development. A group of uncharacterized genes which might be involved in the fetal hematopoiesis were detected.
authors.affiliation: TNLIST/Department of Automation, MOE Key Laboratory of Bioinformatics and Bioinformatics Division, Tsinghua University, Beijing, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Li
authors.forename: Jian
authors.initials: J
authors.lastname: Huang
authors.forename: Ying
authors.initials: Y
authors.lastname: Jiang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zeng
authors.forename: Fuchu
authors.initials: F
authors.lastname: He
authors.forename: Michael Q
authors.initials: MQ
authors.lastname: Zhang
authors.forename: Zeguang
authors.initials: Z
authors.lastname: Han
authors.forename: Xuegong
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000818:Animals; D004622:Embryo, Mammalian / Q000196:embryology; D020869:Gene Expression Profiling / Q000379:methods; D018507:Gene Expression Regulation, Developmental; D008099:Liver / Q000196:embryology*; D051379:Mice / Q000196:embryology*; D008810:Mice, Inbred C57BL / Q000378:metabolism