Regulation of the mammalian nervous system by microRNAs.
The mammalian nervous system exerts essential control on many physiological processes in the organism and is itself controlled extensively by a variety of genetic regulatory mechanisms. MicroRNAs, a class of small, noncoding RNAs, are critical contributors to the regulation of gene expression in the nervous system. Emerging evidence indicates that microRNAs regulate both the development and function of the nervous system. Deficiency in microRNA function has also been implicated in a number of neurological disorders. Understanding the roles of microRNAs will provide new insights into the complexity and operation of the nervous system.
Zeng
Yan
Y
Department of Pharmacology, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA. zengx033@umn.edu
D000818:Animals; D001686:Biological Phenomena; D019143:Evolution, Molecular; D018507:Gene Expression Regulation, Developmental; D008322:Mammals; D035683:MicroRNAs / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D009420:Nervous System / Q000254:growth & development*; D009422:Nervous System Diseases / Q000378:metabolism; D012313:RNA / Q000378:metabolism
D035683:MicroRNAs; D012313:RNA