Autoimmune and inflammatory disorders and risk of malignant lymphomas--an update.
As specific autoimmune disorders now constitute established risk factors for malignant lymphomas, we describe this association. We review reported risk levels, risk determinants, lymphoma subtypes and biological mechanisms in autoimmunity/inflammation, emphasizing on recent findings. Whilst numerous reports describe average lymphoma risks in large patient groups, there's a recent shift of focus to risk determinants and the role of inflammatory activity. Studies highlight associations with diffuse large B-cell lymphoma, apart from lymphoma development in target organs of inflammation. Future studies of high-risk patient subsets using detailed assessments of autoimmunity/inflammation and lymphoma may give important clues to lymphomagenesis.
Smedby
K E
KE
Department of Medicine, Clinical Epidemiology Unit, Karolinska University Hospital, Stockholm, Sweden. karin.ekstrom.smedby@ki.se
Askling
J
J
Mariette
X
X
Baecklund
E
E
D000941:Antigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000150:complications* / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000276:immunology; D008223:Lymphoma / Q000209:etiology* / Q000276:immunology; D012306:Risk
D000941:Antigens; D016207:Cytokines