[Isolation and characterization of the anti-HIV active component from Eucommia ulmoides].
OBJECTIVE
To investigate the anti-HIV effects of Eucommia ulmoides Oliver, so as to provide experimental basis for searching a new efficacious drug for treatment of AIDS.


METHODS
Using phytochemistry to isolate compounds from Eucommia ulmoides Oliver, the inhibitory activity of Samples on the HIV gp41 six-helix bundle formation was determined by a modified sandwich ELISA and PAGE.


RESULTS
The Samples from Eucommia ulmoides Oliver had potent inhibitory activity on the HIV gp41 six-helix bundle formation.


CONCLUSIONS
Eucommia uloides Oliver can inhibit HIV by targeting HIV gp41.
Lv
Lin
L
School of Pharmacy, Southern Medical University, Guangzhou 510515, China. lynnlv@fimmu.com
Sun
Yan-Rong
YR
Xu
Wei
W
Liu
Shu-Wen
SW
Rao
Jin-Jun
JJ
Wu
Shu-Guang
SG
D000818:Animals; D019380:Anti-HIV Agents / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification* / Q000494:pharmacology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D031283:Eucommiaceae / Q000737:chemistry*; D015700:HIV Envelope Protein gp41 / Q000187:drug effects*; D023581:HIV Fusion Inhibitors / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods
D019380:Anti-HIV Agents; D004365:Drugs, Chinese Herbal; D015700:HIV Envelope Protein gp41; D023581:HIV Fusion Inhibitors