title: Towards the clinical application of X-ray phase contrast imaging.
abstract: Synchrotron-based propagation-based imaging, a type of phase contrast imaging, produces better soft tissue image contrast than conventional radiography. To determine whether the technique is directly transferable to the clinical environment for routine diagnostic or screening imaging, a micro-focus (100 microm spot-size) Molybdenum X-ray source with 0.03 mm molybdenum filtration was installed at a local hospital. Breast tissue samples, excised masses and mastectomies, were obtained directly from surgery and imaged at three geometries. The first geometry was optimised for visualizing phase contrast effects using a ray-line argument, the second was the same as that employed by Konica-Minolta in their commercial phase contrast system, and the third was the conventional contact arrangement. The three images taken of each tissue sample were comparatively scored in a pair-wise fashion. Scoring was performed by radiologist expert in mammography, general radiologists, associated clinicians and radiographers on high-resolution mammography rated monitors at two separate locations. Scoring indicated that the optimised and Konica geometries both outperformed the conventional mammographic geometry. An unexpected complication within the trial was the effect that the scoring platform and the associated display tools had on some of the scorer's responses. Additionally, the trial revealed that none of the conventional descriptors for image quality were adequate in the presence of phase contrast enhancements.
authors.affiliation: School of Physics, Monash University, Victoria 3800, Australia. Ivan.williams@sci.monash.edu.au
authors.forename: I M
authors.initials: IM
authors.lastname: Williams
authors.forename: K K W
authors.initials: KK
authors.lastname: Siu
authors.forename: R
authors.initials: R
authors.lastname: Gan
authors.forename: G
authors.initials: G
authors.lastname: Runxuan
authors.forename: X
authors.initials: X
authors.lastname: He
authors.forename: S A
authors.initials: SA
authors.lastname: Hart
authors.forename: C B
authors.initials: CB
authors.lastname: Styles
authors.forename: R A
authors.initials: RA
authors.lastname: Lewis
mesh_terms: D000465:Algorithms; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D008327:Mammography / Q000379:methods*; D011856:Radiographic Image Enhancement / Q000379:methods; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods; D012031:Refractometry / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014056:Tomography, X-Ray / Q000379:methods*