Tandem addition-cyclization reactions of 2-alkynylbenzenamines with isocyanates catalyzed by PdCl2.
Tandem addition-cyclization reactions of 2-alkynylbenzenamines with isocyanates catalyzed by palladium chloride are described. This reaction is performed in the presence of 10 mol% of palladium chloride in THF at 80 degrees C, which provides an efficient and practical route for the synthesis of 1,2-disubstituted indoles.
Ye
Shengqing
S
Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, China.
Ding
Qiuping
Q
Wang
Zhiyong
Z
Zhou
Haibo
H
Wu
Jie
J
D000588:Amines / Q000737:chemistry*; D001554:Benzene / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D017953:Isocyanates / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
D000588:Amines; D017953:Isocyanates; D010165:Palladium; D001554:Benzene; C008756:palladium chloride