title: Clinical evaluation of a resin-based desensitizing agent and a self-etching adhesive on the reduction of postoperative sensitivity of amalgam restorations.
abstract: OBJECTIVE
  The aim of this randomized, double blind clinical trial was to compare three lining materials (Adper Prompt L-Pop, VivaSens, and Copalite) versus unlined restorations on postoperative cold sensitivity of class I amalgam restorations.
  
  
  METHODS
  Potential subjects were screened for the presence of four initial class I carious lesions on posterior teeth. Each tooth was assigned to treatments according to a randomized block design. After cavity preparation, teeth were lined with either VivaSens, Adper Prompt L-Pop, or Copalite, and one tooth remained unlined and served as a control. The cavities were filled with high copper amalgam (Oralloy). The time taken for a subject to respond to a standardized cold stimulus (CRM) was recorded at baseline, 24 hours, one week, and one month after treatment. Participants filled out a self-report questionnaire at each time point. Data was gathered by analysis of variance (ANOVA) and Duncan Multiple Comparisons tests (alpha=0.05).
  
  
  RESULTS
  Twenty subjects participated in this study. Comparisons within each group found no significant reduction in mean CRM for the Adper Prompt L-Pop group (P>0.05), but a significant difference in mean CRM for the VivaSens group was observed at one week and one month intervals after restoration (P<0.05). Copalite and the unlined groups showed significant mean CRM reductions after one day (P<0.05). No significant differences between groups receiving Adper Prompt L-Pop and Copalite were found at any time point (P>0.05). VivaSens showed more cold sensitivity than Adper Prompt L-Pop at one week and one month recalls (P<0.05), while the most cold sensitivity was found in the unlined group.
  
  
  CONCLUSIONS
  Adper Prompt L-Pop and Copalite reduced postoperative sensitivity to cold more than VivaSens and unlined groups at all assessment time points, 24 hours, one week, and one-month post treatment. The subjects receiving Copalite, VivaSens, and unlined restorations experienced greater sensitivity to cold at one month compared to baseline, while subjects receiving the Adper Prompt L-Pop liner experienced no greater sensitivity to cold from baseline to one month.
  
  
  CONCLUSIONS
  Adper Prompt L-Pop as a liner under spherical high copper amalgam successfully reduced cold postoperative sensitivity.
authors.affiliation: Department of Operative Dentistry of the Mashhad Dental School and Dental Research Center at Mashhad University of Medical Sciences in Mashhad, Iran. hajizadehh@mums.ac.ir
authors.forename: Hila
authors.initials: H
authors.lastname: Hajizadeh
authors.forename: Majid
authors.initials: M
authors.lastname: Akbari
authors.forename: Marjaneh
authors.initials: M
authors.lastname: Ghavamnasiri
authors.forename: Sara
authors.initials: S
authors.lastname: Abedini
mesh_terms: D000293:Adolescent; D000328:Adult; D003080:Cold Temperature; D003188:Composite Resins; D003723:Dental Amalgam / Q000009:adverse effects*; D003736:Dental Cavity Lining; D003793:Dental Restoration, Permanent / Q000009:adverse effects*; D003807:Dentin Sensitivity / Q000209:etiology / Q000517:prevention & control*; D004311:Double-Blind Method; D006801:Humans; D019279:Resin Cements; D012116:Resins, Plant; D055815:Young Adult
chemical_list: D003188:Composite Resins; C408584:Prompt L-Pop; D019279:Resin Cements; D012116:Resins, Plant; C525245:VivaSens Liner; C023806:Copalite; D003723:Dental Amalgam