Regioselective double Suzuki couplings of 4,5-dibromothiophene-2-carboxaldehyde.
Conditions have been identified that enable the one-pot double Suzuki coupling of 4,5-dibromothiophene-2-carboxaldehyde to proceed in good yield. The key to success in these reactions is the use of minimal amounts of water to avoid significant amounts of dehalogenation during the first coupling.
Handy
Scott T
ST
Department of Chemistry, Middle Tennessee State University, Murfreesboro, TN 37132.
Mayi
Diyar
D