title: Ainsliatrimers A and B, the first two guaianolide trimers from Ainsliaea fulvioides.
abstract: Ainsliatrimers A (1) and B (2), the first two guaianolide-type sesquiterpene lactone trimers, together with one new structurally related sesquiterpene dimer ainsliadimer B (3), were isolated from the aerial part of Ainsliaea fulvioides. Their structures were elucidated by spectroscopic techniques, including X-ray crystal diffraction. Both 1 and 2 showed potent cytotoxicites against LOVO and CEM cell lines.
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Yun-Heng
authors.initials: YH
authors.lastname: Shen
authors.forename: Hui-Zi
authors.initials: HZ
authors.lastname: Jin
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Fu
authors.forename: Xiao-Jia
authors.initials: XJ
authors.lastname: Hu
authors.forename: Jiang-Jiang
authors.initials: JJ
authors.lastname: Qin
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Liu
authors.forename: Ming
authors.initials: M
authors.lastname: Chen
authors.forename: Shi-Kai
authors.initials: SK
authors.lastname: Yan
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry* / Q000378:metabolism; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008968:Molecular Conformation; D035261:Plant Components, Aerial / Q000737:chemistry / Q000378:metabolism; D045789:Sesquiterpenes, Guaiane / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014961:X-Ray Diffraction
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D045789:Sesquiterpenes, Guaiane; C543081:ainsliatrimer A; C543082:ainsliatrimer B