title: Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK?
abstract: An approach and preliminary results for utilizing legacy MEK inhibitors as templates for a reiterative structural based design and synthesis of novel, type III NCKIs (non-classical kinase inhibitors) is described. Evidence is provided that the MEK-pocket or pockets closely related to it may exist in kinases other than MEK.
authors.affiliation: Pfizer Global Research and Development, Research Technology Center, Cambridge, MA 02139, USA. haile.tecle@pfizer.com
authors.forename: Haile
authors.initials: H
authors.lastname: Tecle
authors.forename: Jianxing
authors.initials: J
authors.lastname: Shao
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Li
authors.forename: Michael
authors.initials: M
authors.lastname: Kothe
authors.forename: Steven
authors.initials: S
authors.lastname: Kazmirski
authors.forename: Julie
authors.initials: J
authors.lastname: Penzotti
authors.forename: Yuan-Hua
authors.initials: YH
authors.lastname: Ding
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Ohren
authors.forename: Deb
authors.initials: D
authors.lastname: Moshinsky
authors.forename: Rocco
authors.initials: R
authors.lastname: Coli
authors.forename: Nidhi
authors.initials: N
authors.lastname: Jhawar
authors.forename: Emilia
authors.initials: E
authors.lastname: Bora
authors.forename: Suzanne
authors.initials: S
authors.lastname: Jacques-O'Hagan
authors.forename: Joe
authors.initials: J
authors.lastname: Wu
mesh_terms: D020134:Catalytic Domain; D015195:Drug Design; D020929:Mitogen-Activated Protein Kinase Kinases / Q000037:antagonists & inhibitors*; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D047428:Protein Kinase Inhibitors; D020929:Mitogen-Activated Protein Kinase Kinases