title: Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products.
abstract: Solid lipid nanoparticles (SLN) are distinguishable from nanostructured lipid carriers (NLC) by the composition of the solid particle matrix. Both are an alternative carrier system to liposomes and emulsions. This review paper focuses on lipid nanoparticles for dermal application. Production of lipid nanoparticles and final products containing lipid nanoparticles is feasible by well-established production methods. SLN and NLC exhibit many features for dermal application of cosmetics and pharmaceutics, i.e. controlled release of actives, drug targeting, occlusion and associated with it penetration enhancement and increase of skin hydration. Due to the production of lipid nanoparticles from physiological and/or biodegradable lipids, this carrier system exhibits an excellent tolerability. The lipid nanoparticles are a "nanosafe" carrier. Furthermore, an overview of the cosmetic products currently on the market is given and the improvement of the benefit/risk ratio of the topical therapy is shown.
authors.affiliation: Department of Pharmaceutical Technology, Biopharmaceutics and Nutricosmetics, Freie Universität Berlin, Berlin, Germany.
authors.forename: Jana
authors.initials: J
authors.lastname: Pardeike
authors.forename: Aiman
authors.initials: A
authors.lastname: Hommoss
authors.forename: Rainer H
authors.initials: RH
authors.lastname: Müller
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D003358:Cosmetics / Q000008:administration & dosage* / Q000009:adverse effects; D003692:Delayed-Action Preparations; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D008055:Lipids / Q000737:chemistry; D053758:Nanoparticles / Q000009:adverse effects; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*
chemical_list: D003358:Cosmetics; D003692:Delayed-Action Preparations; D008055:Lipids; D004364:Pharmaceutical Preparations