Transient myeloproliferative disorder in neonates with and without Down syndrome: a tale of 2 syndromes.
Transient myeloproliferative disorder (TMD) in newborns with Down syndrome (DS) has been well described. We report 4 newborns, 2 with DS and 2 without DS, who developed TMD. One newborn with DS developed multiorgan failure and died despite treatment with low-dose cytarabine. In 3 newborns, the TMD resolved spontaneously. Two of these patients, 1 with and 1 without DS developed leukemia on subsequent follow-up and were treated successfully. We reviewed the clinical and laboratory data on 14 non-DS infants with TMD reported in the literature. According to limited data, these patients are more likely to develop leukemia than DS patients, however their outcome is better.
Apollonsky
Nataly
N
Division of Pediatric Hematology/Oncology and Stem Cell Transplantation, Schneider Children's Hospital, New Hyde Park, NY, USA. napollonsky@yahoo.com
Shende
Ashok
A
Ouansafi
Ihsane
I
Brody
Judith
J
Atlas
Mark
M
Aygun
Banu
B
D002869:Chromosome Aberrations; D004314:Down Syndrome / Q000150:complications* / Q000235:genetics / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009196:Myeloproliferative Disorders / Q000150:complications* / Q000235:genetics / Q000473:pathology