title: High rate of long-term survival for high-risk lymphoma patients treated with hematopoietic stem cell transplantation as consolidation or salvage therapy.
abstract: Patients with high-relapse-risk lymphomas or those relapsing after initial therapy have a limited probability of cure with conventional treatment. There is recent inconclusive evidence that, in such cases, intensification or salvage treatment with high-dose chemotherapy followed by hematopoietic stem cell transplantation (HSCT) increases the response rate and may improve survival. Nevertheless, published data on long-term follow-up of high-risk lymphoma patients treated with HSCT are scarce. We analyzed 101 consecutive patients receiving high-dose chemotherapy followed by HSCT after induction with standard chemotherapy. The median age was 38 years (range, 12-63 years). The diagnoses were Hodgkin's disease (n = 32), follicular lymphoma (n = 33), diffuse large B-cell lymphoma (n = 12), mantle cell lymphoma (n = 7), T-cell lymphoma (n = 14), and others (n = 3). Patients received either an autologous graft (n = 72) in first complete remission (1CR; n = 23) or in advanced stages (AS; n = 49), or an allogeneic graft (n = 29) in 1CR (n = 7) or in AS (n = 22). We concluded that transplant-related mortality was 2.7% for patients receiving an autologous HSCT and 27% for patients receiving an allogeneic HSCT. The main etiologies were graft-versus-host disease and infection in the allogeneic setting, and infection in the autologous setting. The probability of long-term (12-year) overall survival was 71%, higher than that described for high-relapse-risk lymphoma patients treated without HSCT and significantly better (P < .05) for patients who received the transplant in 1CR (89%) than in AS (65%). Finally, the probability of long-term survival was significantly better for patients treated with HSCT during the period from 2000-2007 (85%) compared with the period from 1989-1999 (72%).
authors.affiliation: Servicio de Hematología y Hemoterapia, Hospitales Universitarios Virgen del Rocío, Seville, Spain. ildefonso.espigado.sspa@juntadeandalucia.es
authors.forename: I
authors.initials: I
authors.lastname: Espigado
authors.forename: E
authors.initials: E
authors.lastname: Ríos
authors.forename: A
authors.initials: A
authors.lastname: Marín-Niebla
authors.forename: M
authors.initials: M
authors.lastname: Carmona
authors.forename: R
authors.initials: R
authors.lastname: Parody
authors.forename: J M
authors.initials: JM
authors.lastname: Pérez-Hurtado
authors.forename: F J
authors.initials: FJ
authors.lastname: Márquez
authors.forename: A
authors.initials: A
authors.lastname: Urbano-Ispizua
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods* / Q000401:mortality; D006801:Humans; D008223:Lymphoma / Q000401:mortality / Q000601:surgery*; D008875:Middle Aged; D011336:Probability; D012189:Retrospective Studies; D016879:Salvage Therapy; D016019:Survival Analysis; D017741:Survivors / Q000706:statistics & numerical data*; D019172:Transplantation Conditioning; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D055815:Young Adult