Effect of strength training session on plasma amino acid concentration following oral ingestion of leucine, BCAAs or glutamine in men.
We examined the acute effects of a 1-h strength training session (STS) on plasma amino acid concentration following orally ingestion of leucine, branched-chain amino acids (BCAAs) or glutamine in nine physically active men who participated in double-blinded and randomised experiments. The subjects took placebo, leucine, BCAAs, or glutamine capsules (50 mg/kg) in either rest (REST) or STS condition. Blood samples were taken before and at 30, 60, 90, and 120 min after the beginning of the treatment and they were assayed for plasma amino acids with HPLC. Following both leucine and BCAA ingestion the peak concentration of leucine was similar at rest (524 +/- 46 and 530 +/- 29 nmol/ml, respectively) and similar after STS (398 +/- 43 and 387 +/- 46 nmol/ml, respectively) but the rest and STS concentrations differed from each other (P < 0.01-0.001). The modelled polynomial data for the leucine treatment showed that the peak concentration of leucine occurred at 67 min at rest and at 90 min in STS (difference between REST and STS: P = 0.012). For the BCAA treatment the polynomial data showed that the peak concentration of leucine occurred at 72 min at rest and at 78 min in STS (P = 0.067). The peak concentration of glutamine was similar in both rest and STS condition and occurred at 60 min at rest and at 57 min in STS. In conclusion, 1-h of STS slows the increase in the peak concentration of plasma leucine similarly after oral ingestion of leucine or BCAAs but after oral ingestion of glutamine it has no slowing effect on glutamine concentration.
Mero
Antti
A
Department of Biology of Physical Activity, University of Jyväskylä, PO Box 35, 40014 Jyväskylä, Finland. antti.mero@sport.jyu.fi
Leikas
Anne
A
Knuutinen
Juha
J
Hulmi
Juha J
JJ
Kovanen
Vuokko
V
D000328:Adult; D004311:Double-Blind Method; D005973:Glutamine / Q000097:blood* / Q000493:pharmacokinetics*; D006801:Humans; D007930:Leucine / Q000097:blood* / Q000493:pharmacokinetics*; D008297:Male; D008657:Metabolic Clearance Rate; D010807:Physical Endurance / Q000187:drug effects; D055070:Resistance Training; D012146:Rest / Q000502:physiology
D005973:Glutamine; D007930:Leucine