title: [Invasive aspergillosis of the paranasal sinuses, lung and brain].
abstract: A case of invasive aspergillosis (IA) of paranasal sinuses, lung and brain with a fulminant fatal outcome is reported. A 43-year-old man with a history of skin carcinoma of the nasal region and a course of systemic corticosteroids, presented with symptoms of lung infection. Aspergillus fumigatus was cultured from respiratory and nasal samples. Erosion of adjacent bones of the nasal cavity was acknowledged, but no sinus surgery was performed. A computed tomography of the thorax showed thick-walled cavities of different sizes with air and scarce fluid levels in both lungs. Treatment with voriconazole was administered. The patient deteriorated in the ensuing 2 weeks because central nervous system involvement was observed. No aggressive surgical resection was performed and the patient died 2 weeks later. IA was not confirmed by histopathology because no necropsy was performed.
authors.affiliation: Klinika Pneumonologii Katedry Pneumonologii i Alergologii Akademii Medycznej w Gdańsku Kierownik Katedry. kkedz@amg.gda.pl
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Kedziora
authors.forename: Jan Marek
authors.initials: JM
authors.lastname: Słomiński
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Gil
authors.forename: Maria
authors.initials: M
authors.lastname: Porzezińska
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Gorzewska
mesh_terms: D000328:Adult; D001228:Aspergillosis / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D001927:Brain Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000382:microbiology; D017809:Fatal Outcome; D006801:Humans; D008172:Lung Diseases, Fungal / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000382:microbiology; D008297:Male; D010254:Paranasal Sinus Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000382:microbiology; D011859:Radiography