Improvements in signs and symptoms during hospitalization for acute heart failure follow different patterns and depend on the measurement scales used: an international, prospective registry to evaluate the evolution of measures of disease severity in acute heart failure (MEASURE-AHF).
BACKGROUND
The natural evolution of signs and symptoms during acute heart failure (AHF) is poorly characterized.


RESULTS
We followed a prospective international cohort of 182 patients hospitalized with AHF. Patient-reported dyspnea and general well-being (GWB) were measured daily using 7-tier Likert (-3 to +3) and visual analog scales (VAS, 0-100). Physician assessments were also recorded daily. Mean age was 69 years and 68% had ejection fraction <40%. Likert measures of dyspnea initially improved rapidly (day 1, 0.22; day 2, 1.31; P <.001) with no significant improvement thereafter (day 7, 1.51; day 2 versus 7 P = .16). In contrast, VAS measure of dyspnea improved throughout hospitalization (day 1, 50.1; day 2, 64.7; day 7, 83.2; day 1 versus 2 P < .001, day 2 versus 7 P < .001). Symptoms of dyspnea and GWB tracked closely (correlation r = .813, P < .001). Physical signs resolved more completely than did symptoms (eg, from day 1 to discharge/day 7, absence of edema increased from 33% to 72% of patients, whereas significant improvements in dyspnea increased from 27% to 52% of patients; P < .001).


CONCLUSIONS
Changes in patient-reported symptoms and physician-assessed signs followed different patterns during an AHF episode and are influenced by the measurement scales used. Multiple clinical measures should be considered in discharge decisions and evaluation of AHF therapies.
Allen
Larry A
LA
Division of Cardiology, University of Colorado Denver, Aurora, CO 80045, USA. larry_allen@post.harvard.edu
Metra
Marco
M
Milo-Cotter
Olga
O
Filippatos
Gerasimos
G
Reisin
Leonardo H
LH
Bensimhon
Daniel R
DR
Gronda
Edoardo G
EG
Colombo
Paolo
P
Felker
G Michael
GM
Cas
Livio Dei
LD
Kremastinos
Dimitrios T
DT
O'Connor
Christopher M
CM
Cotter
Gadi
G
Davison
Beth A
BA
Dittrich
Howard C
HC
Velazquez
Eric J
EJ
D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D006333:Heart Failure / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D038622:Internationality; D008297:Male; D008875:Middle Aged; D010343:Patient Admission / Q000592:standards / Q000639:trends*; D010351:Patient Discharge / Q000592:standards / Q000639:trends*; D011446:Prospective Studies; D012042:Registries / Q000592:standards*; D012720:Severity of Illness Index; D014894:Weights and Measures / Q000592:standards*