title: Functional cardiac CT imaging: a new contrast application strategy for a better visualization of the cardiac chambers.
abstract: OBJECTIVE
  Evaluation of a new protocol for Dual-source CT contrast-enhanced cardiac imaging for better visualization of right ventricle structures.
  
  
  METHODS
  A total of 106 patients were included in this prospective, controlled study. The control group (n=53) underwent our clinic's standard procedure for contrast-enhanced imaging of coronary arteries. The study group (n=53) was imaged using a protocol with the dual flow injection protocol in which the saline chaser bolus contained 20% contrast media. The images were analyzed for mean density values using defined ROIs in the septum and both ventricles. In addition the data sets were semi-quantitatively evaluated for visual delineation between right ventricle and septum. To investigate whether this new protocol influenced the visualization of coronary arteries, mean density was also measured in the right and left coronary artery.
  
  
  RESULTS
  The dual flow concept allows for a statistically significant better delineation of the septum in Dual-source cardiac computed tomography for both the quantitative and semi-quantitative analyses. Also, the dual flow concept allows for statistically relevant higher coronary attenuation.
  
  
  CONCLUSIONS
  Using a saline chaser containing 20% contrast medium improves septal delineation for functional ventricular analysis as well as unimpaired coronary visualization.
authors.affiliation: Radiological Institute, Friedrich-Alexander-University-Erlangen-Nuremberg, Maximiliansplatz 1, 91054 Erlangen, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Wuest
authors.forename: Christian
authors.initials: C
authors.lastname: Zunker
authors.forename: Katharina
authors.initials: K
authors.lastname: Anders
authors.forename: Dieter
authors.initials: D
authors.lastname: Ropers
authors.forename: Stephan
authors.initials: S
authors.lastname: Achenbach
authors.forename: Werner
authors.initials: W
authors.lastname: Bautz
authors.forename: Axel
authors.initials: A
authors.lastname: Kuettner
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media / Q000008:administration & dosage*; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D007479:Iopamidol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008297:Male; D008875:Middle Aged; D011856:Radiographic Image Enhancement / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*; D018497:Ventricular Dysfunction, Right / Q000000981:diagnostic imaging*
chemical_list: D003287:Contrast Media; C057937:iomeprol; D007479:Iopamidol