Intercellular junctions: actin the PARt.
Several distinct polarity complexes participate in the assembly of intercellular junctions. Two studies showing that some of the same polarity complexes are essential regulators of continued junctional integrity lead to a new appreciation of the relationships between assembly and maintenance of intercellular junctions and highlight unappreciated roles for endocytosis in these processes.
Shen
Le
L
Department of Pathology, University of Chicago, Chicago, IL 60637, USA.
Turner
Jerrold R
JR
D000199:Actins / Q000378:metabolism; D022005:Adherens Junctions / Q000378:metabolism*; D000818:Animals; D015820:Cadherins / Q000378:metabolism*; D004330:Drosophila / Q000378:metabolism; D029721:Drosophila Proteins / Q000378:metabolism; D004705:Endocytosis; D011493:Protein Kinase C / Q000378:metabolism; D020764:cdc42 GTP-Binding Protein / Q000378:metabolism
D000199:Actins; D015820:Cadherins; D029721:Drosophila Proteins; C115015:PKC-3 protein; C532584:Par-6 protein, Drosophila; D011493:Protein Kinase C; D020764:cdc42 GTP-Binding Protein