Targeting protein-protein interactions: suppression of Stat3 dimerization with rationally designed small-molecule, nonpeptidic SH2 domain binders.
Gunning
Patrick T
PT
Department of Chemistry, Yale University, P. O. Box 208017, New Haven, CT 06520-8107, USA.
Glenn
Matthew P
MP
Siddiquee
Khandaker A Z
KA
Katt
William P
WP
Masson
Eric
E
Sebti
Saïd M
SM
Turkson
James
J
Hamilton
Andrew D
AD
D000818:Animals; D001665:Binding Sites; D001667:Binding, Competitive; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D008024:Ligands; D051379:Mice; D008958:Models, Molecular; D041681:NIH 3T3 Cells; D011485:Protein Binding; D055503:Protein Multimerization / Q000187:drug effects; D050796:STAT3 Transcription Factor / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D054852:Small Molecule Libraries / Q000737:chemistry* / Q000494:pharmacology; D018909:src Homology Domains
D008024:Ligands; D050796:STAT3 Transcription Factor; D054852:Small Molecule Libraries