N-Acylhomoserine lactone-mediated quorum sensing: a twist in the tail and a blow for host immunity.
Communication through quorum sensing (QS) enables bacterial populations to coordinate their behavior. Recent work on N-acylhomoserine lactone-mediated QS has revealed that some soil bacteria exploit host-derived substrates to generate an alternative N-substituted homoserine lactone. New light has also been shed on the mechanism by which N-(3-oxo-dodecanoyl)-L-homoserine lactone modulates host inflammatory signaling pathways to promote bacterial survival.
Cooley
Margaret
M
Menzies Research Institute and School of Medicine, University of Tasmania, Hobart, TAS 7001, Australia.
Chhabra
Siri Ram
SR
Williams
Paul
P
D054742:Acyl-Butyrolactones / Q000378:metabolism*; D000818:Animals; D001419:Bacteria / Q000166:cytology / Q000378:metabolism; D018407:Bacterial Physiological Phenomena; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D007109:Immunity; D053038:Quorum Sensing
D054742:Acyl-Butyrolactones