Molecularly imprinted cavities template the macrocyclization of tetrapeptides.
Cavities formed using cyclic tetrapeptides (CTPs) or heat-induced conformers act as templates for cyclization; the cavities bind to linear tetrapeptides and enforce turn conformations to enhance cyclization to constrained CTPs.
Tai
Dar-Fu
DF
Department of Chemistry, National Dong-Hwa University, Hualien, Taiwan. dftai@mail.ndhu.edu.tw
Lin
Yee-Fung
YF
D003500:Cyclization; D006358:Hot Temperature; D054802:Molecular Imprinting; D015394:Molecular Structure; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry*
D009842:Oligopeptides