Divergence in cis-regulatory networks: taking the 'species' out of cross-species analysis.
Many essential transcription factors have conserved roles in regulating biological programs, yet their genomic occupancy can diverge significantly. A new study demonstrates that such variations are primarily due to cis-regulatory sequences, rather than differences between the regulators or nuclear environments.
Zinzen
Robert P
RP
European Molecular Biology Laboratory, D-69117 Heidelberg, Germany.
Furlong
Eileen E M
EE
D000818:Animals; D012321:DNA-Directed RNA Polymerases; D019143:Evolution, Molecular; D053263:Gene Regulatory Networks; D006801:Humans; D013045:Species Specificity; D014157:Transcription Factors / Q000235:genetics*; D014158:Transcription, Genetic
D014157:Transcription Factors; D012321:DNA-Directed RNA Polymerases