Predictive factors for pregnancy after intrauterine insemination (IUI): an analysis of 1038 cycles and a review of the literature.
OBJECTIVE
To determine the predictive factors for pregnancy after IUI.


METHODS
Retrospective study.


METHODS
A single university medical center.


METHODS
One thousand thirty-eight IUI cycles in 353 couples were studied between 2002 and 2005.


METHODS
Ovarian stimulation via SC injection of FSH or hMG was performed daily; IUI was then performed 36 hours after triggering ovulation if at least one follicle measuring >16 mm and an endometrial thickness of >7 mm (with triple-line development) were obtained.


METHODS
Clinical pregnancy rates were analyzed according to the woman's age, the type of infertility, the spermogram characteristics, the total motile spermatozoa (TMS) count, the E(2) level before hCG injection, and the number of mature follicles.


RESULTS
The couple with the best chance of pregnancy can be described as follows: an under 30 woman with cervical or anovulatory infertility and a man with a TMS >or=5 million spermatozoa. The "ideal" stimulation cycle enables the recruitment of two follicles measuring >16 mm with an E(2) concentration >500 pg/mL on the day of hCG administration. The best results are obtained when IUI is performed using a soft catheter.


CONCLUSIONS
This study enabled the characterization of many prognostic factors for pregnancy and particularly those for women at risk of multiple pregnancies after IUI.
Merviel
Philippe
P
Department of Gynecology, Obstetrics and Reproductive Medicine, Amiens University Medical Center, Amiens, France. merviel.philippe@chu-amiens.fr
Heraud
Marie Hélène
MH
Grenier
Nadège
N
Lourdel
Emmanuelle
E
Sanguinet
Pierre
P
Copin
Henri
H
D000328:Adult; D000367:Age Factors; D015415:Biomarkers / Q000097:blood; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D004867:Equipment Design; D004958:Estradiol / Q000097:blood; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage; D006801:Humans; D007246:Infertility / Q000097:blood / Q000473:pathology / Q000628:therapy*; D007279:Injections, Subcutaneous; D007315:Insemination, Artificial / Q000295:instrumentation; D016015:Logistic Models; D008297:Male; D008596:Menotropins / Q000008:administration & dosage; D016017:Odds Ratio; D010062:Ovulation Induction; D011237:Predictive Value of Tests; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013076:Sperm Count; D013081:Sperm Motility; D013094:Spermatozoa / Q000473:pathology; D016896:Treatment Outcome; D014427:Twins
D015415:Biomarkers; D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female; D004958:Estradiol; D008596:Menotropins; D005640:Follicle Stimulating Hormone