title: A long-term user of cosmetic cream containing estrogen developed breast cancer and endometrial hyperplasia.
abstract: A 93-year-old woman was referred to our clinic for abnormal genital bleeding. It was found that she had endometrial hyperplasia and breast cancer. Her uterus was as large as that of a normal adult menstruating woman. She indicated that she had been applying cosmetic cream containing a low concentration of ethynylestradiol to her face and body three times a day for 75 years. It is possible that this long-term use of the ethynylestradiol-containing cream is related to the development of breast cancer and endometrial hyperplasia.
authors.affiliation: Department of Obstetrics and Gynecology, Hyogo College of Medicine, Hyogo, Japan. komor615@hyo-med.ac.jp
authors.forename: Shinji
authors.initials: S
authors.lastname: Komori
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Ito
authors.forename: Yuri
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Michi
authors.initials: M
authors.lastname: Aoki
authors.forename: Takenobu
authors.initials: T
authors.lastname: Takashi
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Kinuta
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Koji
authors.initials: K
authors.lastname: Koyama
mesh_terms: D000279:Administration, Cutaneous; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000209:etiology*; D003358:Cosmetics / Q000009:adverse effects*; D004714:Endometrial Hyperplasia / Q000209:etiology*; D004967:Estrogens / Q000008:administration & dosage / Q000009:adverse effects*; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans
chemical_list: D003358:Cosmetics; D004967:Estrogens; D004997:Ethinyl Estradiol