title: Organocatalytic Michael addition of aldehydes to gamma-keto-alpha,beta-unsaturated esters. an efficient entry to versatile chiral building blocks.
abstract: The diarylprolinol ether/HOAc-catalyzed Michael addition of aldehydes to gamma-keto-alpha,beta-unsaturated esters occurs in a highly regioselective and enantioselective manner. The adducts could easily be converted into synthetically useful cyclohexenones, cyclohexanones, piperidines, and gamma-lactones.
authors.affiliation: State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Anqi
authors.initials: A
authors.lastname: Ma
authors.forename: Dawei
authors.initials: D
authors.lastname: Ma
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D004952:Esters; D007659:Ketones / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D004952:Esters; D007659:Ketones