title: [Methodological aspects on new protocols in oncology].
abstract: This review will summarize specific methodological aspects in targeted therapies like EPR (early progression rate) or RDD (randomized discontinuation design), along with Adaptive Design such as CRM (continual reassessment method, Eff-TOX (dose-finding based on efficacy-toxicity, PPD (predictive probability design) or ADTT (adaptive randomization for targeted therapy) methods.
authors.affiliation: Centre Alexis-Vautrin, Vandoeuvre-les-Nancy. luporsi.elisabeth@wanadoo.fr
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Luporsi
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002985:Clinical Protocols; D002986:Clinical Trials as Topic; D006801:Humans; D020714:Maximum Tolerated Dose; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents