title: Cord blood stem cell therapy for acquired immune deficiency syndrome.
abstract: Cord blood stem cell transplantation is routinely used to treat hematopoietic diseases. Individuals who are homozygous for the 32 polymorphism of the CCR5 locus, encoding a co-receptor for HIV-1, are normal and are resistant to HIV infection. Here we suggest that public cord blood repositories are likely to contain CCR5 homozygous units that could be used as a therapy for HIV-infected individuals.
authors.affiliation: Department of Genetics, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Gonzalez
authors.forename: Elizabeth J
authors.initials: EJ
authors.lastname: Shpall
authors.forename: Joseph C
authors.initials: JC
authors.lastname: Gathe
authors.forename: Richard R
authors.initials: RR
authors.lastname: Behringer
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000601:surgery*; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D036101:Cord Blood Stem Cell Transplantation; D005312:Fetal Blood / Q000166:cytology*; D015497:HIV-1 / Q000378:metabolism; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000502:physiology*; D006801:Humans; D011110:Polymorphism, Genetic; D019713:Receptors, CCR5 / Q000235:genetics
chemical_list: D019713:Receptors, CCR5