title: Treatment experiences of testicular cancer in Hispanic patients with Down's syndrome at the National Cancer Institute of Mexico.
abstract: We present 4 case studies of patients with Down's syndrome and testicular germ-cell cancer, treated with conventional methods at the National Cancer Institute of Mexico, with similar outcomes as patients without this syndrome. There are several reports of testicular cancer arising in patients with Down's syndrome worldwide, mainly from Caucasian populations. We discuss some theories about the association and the possible increase of incidence.
authors.affiliation: Department of Medical Oncology, Instituto Nacional de Cancerología (INCan), Distrito Federal, México. oncoincan@hotmail.com
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Aguilar-Ponce
authors.forename: Silvia
authors.initials: S
authors.lastname: Vidal-Millán
authors.forename: Carlos
authors.initials: C
authors.lastname: Molina-Calzada
authors.forename: Fatima
authors.initials: F
authors.lastname: Chilaca-Rosas
authors.forename: Jorge
authors.initials: J
authors.lastname: Martínez-Cedillo
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Cruz-López
mesh_terms: D000015:Abnormalities, Multiple; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage; D001932:Brain Neoplasms / Q000556:secondary; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003456:Cryptorchidism / Q000150:complications; D004314:Down Syndrome / Q000150:complications*; D005047:Etoposide / Q000008:administration & dosage; D017809:Fatal Outcome; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D008800:Mexico; D009373:Neoplasms, Germ Cell and Embryonal / Q000150:complications* / Q000473:pathology / Q000556:secondary / Q000601:surgery; D009919:Orchiectomy; D012074:Remission Induction; D012186:Retroperitoneal Neoplasms / Q000532:radiotherapy / Q000556:secondary; D018239:Seminoma / Q000150:complications / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D013736:Testicular Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D001761:Bleomycin; D005047:Etoposide; D002945:Cisplatin