title: Protection against neurodegenerative diseases of Iris pseudopumila extracts and their constituents.
abstract: The present study describes for the first time the in vitro properties of Iris pseudopumila flowers and rhizomes extracts and their constituents. The methanolic extract of rhizomes showed significant anti-inflammatory activity through inhibition of NO production in the murine monocytic macrophage cell line RAW 264.7. Among the isolated compounds, those which most effectively inhibited LPS-induced NO production were irisolidone and 7-methyl-tectorigenin-4'-O-[beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranoside], with IC(50) values of 23.6 microM and 29.4 microM respectively. Isoorientin and isovitexin exhibited the most promising activity against AChE with IC(50) of 26.8 microM and 36.4 microM, respectively. The same compounds exhibited also the higher activity against BChE.
authors.affiliation: Department of Pharmaceutical Sciences, University of Calabria, I-87036 Rende (CS), Italy. filomena.conforti@unical.it
authors.forename: Filomena
authors.initials: F
authors.lastname: Conforti
authors.forename: Daniela
authors.initials: D
authors.lastname: Rigano
authors.forename: Federica
authors.initials: F
authors.lastname: Menichini
authors.forename: Monica Rosa
authors.initials: MR
authors.lastname: Loizzo
authors.forename: Felice
authors.initials: F
authors.lastname: Senatore
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D047310:Apigenin / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D003603:Cytotoxins / Q000737:chemistry / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D005960:Glucosides / Q000737:chemistry / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D031323:Iris Plant / Q000737:chemistry*; D007529:Isoflavones / Q000737:chemistry / Q000494:pharmacology; D047311:Luteolin / Q000737:chemistry / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D009569:Nitric Oxide / Q000037:antagonists & inhibitors*; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D027343:Rhizome
chemical_list: C539600:7-methyl-tectorigenin-4'-O-beta-D-glucopyranoside; D000893:Anti-Inflammatory Agents; D002800:Cholinesterase Inhibitors; D003603:Cytotoxins; D005419:Flavonoids; D005960:Glucosides; D007529:Isoflavones; D010936:Plant Extracts; C423902:irisolidone; D009569:Nitric Oxide; D047310:Apigenin; C057912:homoorientin; C049772:isovitexin; D047311:Luteolin