Cyclin-like oscillations in levels of the nucleoporin Nup96 control G1/S progression.
In this issue of Developmental Cell, Chakraborty et al. report that efficient advancement through G1/S phase requires the downregulation of Nup96 levels during M phase. The authors show that oscillations in Nup96 levels plays a key role in maintaining normal cell proliferation, likely by regulating the export of specific mRNAs, including those of key cell cycle regulators.
Wozniak
Richard W
RW
Department of Cell Biology, University of Alberta, Edmonton, AB T6G 2H7, Canada. rick.wozniak@ualberta.ca
Goldfarb
David S
DS
D000818:Animals; D002453:Cell Cycle; D006801:Humans; D008938:Mitosis; D028861:Nuclear Pore Complex Proteins / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism
D028861:Nuclear Pore Complex Proteins; D012333:RNA, Messenger; C119239:nuclear pore complex protein 96