title: Arrhythmogenesis and diagnosis of cardiac sarcoidosis. An immunohistochemical study in a sudden cardiac death.
abstract: We present an uncommon case of sudden cardiac death in a 34-year-old white woman. She was found lifeless at home by her parents. Three months before death she was recovered at the Emergency Room for chest pain, palpitation and loss of consciousness. Subsequent cardiological evaluation with ECG showed sinusal rhythm, QRS deviation to the left, QS aspect, asymmetric and rounded T waves and slight length of QT. During hospitalization she presented some episodes of supraventricular paroxysmal tachycardia and non-sustained ventricular tachycardia. No echocardiography alterations were found. An anti-arrhythmic treatment was prescribed. Autopsy revealed some fibrotic scarring in the myocardium of left ventricle. The histological examination of the heart revealed diffuse and extensive fibrosis with non-caseating sarcoid granulomas. The lungs, kidneys and lymph node also showed the same non-caseating granulomas. The diagnosis of sarcoidosis with massive and extensive cardiac involvement was established as cause of death.
authors.affiliation: Department of Forensic Pathology, University of Foggia - Ospedale Colonnello D'Avanzo, Via degli Aviatori 1, 71100 Foggia, Italy.
authors.forename: Irene
authors.initials: I
authors.lastname: Riezzo
authors.forename: Francesco
authors.initials: F
authors.lastname: Ventura
authors.forename: Stefano
authors.initials: S
authors.lastname: D'Errico
authors.forename: Margherita
authors.initials: M
authors.lastname: Neri
authors.forename: Emanuela
authors.initials: E
authors.lastname: Turillazzi
authors.forename: Vittorio
authors.initials: V
authors.lastname: Fineschi
mesh_terms: D000328:Adult; D015703:Antigens, CD; D009202:Cardiomyopathies / Q000175:diagnosis*; D016757:Death, Sudden, Cardiac; D004562:Electrocardiography; D005260:Female; D005355:Fibrosis; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney / Q000473:pathology; D008168:Lung / Q000276:immunology / Q000473:pathology; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D009206:Myocardium / Q000276:immunology / Q000473:pathology; D012507:Sarcoidosis / Q000175:diagnosis*; D013617:Tachycardia, Supraventricular / Q000209:etiology*; D017180:Tachycardia, Ventricular / Q000209:etiology*
chemical_list: D015703:Antigens, CD