title: Radiotherapy-related tiredness in patients with glioblastoma multiforme (GBM).
abstract: Tiredness may be caused by the brain injury due to the tumor or the treatment in patients with glioblastoma multiforme (GBM). Some patients describe a sense of tiredness particularly after radiation or oral chemotherapy. To evaluate tiredness level of patients with GBM during preoperative, postoperative and radiotherapy we here eamined a sample of 38 patients. Data were collected over six months in a neurosurgery clinic. Patients assigned to Group I were given a booklet and information about radiotherapy, oral temozolomide and tiredness. Group II received only the booklet. The chi-squared test were used to determine differences in tiredness between Group I and Group II, with Spearman's correlation for post-radiotherapy results (3 and 6 months postoperative). In conclusion, the level of tiredness was assessed to be significantly better in Group I than in Group II. Levels of tiredness in patients with GBM were greatly affected by the radiotherapy and oral chemotherapy (temozolomide).
authors.affiliation: Canakkale On Sekiz Marta University, School of Public Health.. arzutunamalak@gmail.com
authors.forename: Arzu
authors.initials: A
authors.lastname: Tuna-Malak
authors.forename: Alev
authors.initials: A
authors.lastname: Diramali
mesh_terms: D001932:Brain Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D016009:Chi-Square Distribution; D016371:Cranial Irradiation / Q000009:adverse effects* / Q000379:methods; D004307:Dose-Response Relationship, Radiation; D005221:Fatigue / Q000453:epidemiology* / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D005909:Glioblastoma / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care / Q000379:methods; D011300:Preoperative Care / Q000379:methods; D011336:Probability; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D018570:Risk Assessment; D012494:Sampling Studies; D012720:Severity of Illness Index; D013997:Time Factors