title: Correlations of six related purine metabolites and diabetic nephropathy in Chinese type 2 diabetic patients.
abstract: OBJECTIVE
  The assessment of the clinical significance of adenosine, adenine, inosine, xanthine, hypoxanthine and uric acid concentrations in patients with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN) for the detection of the relationship between purine metabolites and disease.
  
  
  METHODS
  The study group consisted of 119 subjects which were divided into three groups: control (n=31), type 2 diabetes without nephropathy (DM, n=23) and with nephropathy (DN, n=65). Levels of related metabolites were measured in plasma of all participants.
  
  
  RESULTS
  There is a significant increase of levels of adenosine (P<0.001), inosine (P<0.001), xanthine (P=0.012) and uric acid (P=0.016) with DN compared to DM. The level of xanthine oxidase (reflected by the uric acid: xanthine) did not change.
  
  
  CONCLUSIONS
  The levels of adenosine, inosine, uric acid and xanthine may be useful for monitoring the progression of DM and evaluating the treatment.
authors.affiliation: School of Pharmaceutics, East-China University of Science and Technology, China.
authors.forename: Jian-Fei
authors.initials: JF
authors.lastname: Xia
authors.forename: Qiong-Lin
authors.initials: QL
authors.lastname: Liang
authors.forename: Ping
authors.initials: P
authors.lastname: Hu
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Wang
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.forename: Guo-An
authors.initials: GA
authors.lastname: Luo
mesh_terms: D000241:Adenosine / Q000097:blood; D000368:Aged; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000378:metabolism; D003928:Diabetic Nephropathies / Q000097:blood* / Q000378:metabolism; D005260:Female; D006801:Humans; D007288:Inosine / Q000097:blood; D008297:Male; D008875:Middle Aged; D011687:Purines / Q000097:blood* / Q000378:metabolism; D014527:Uric Acid / Q000097:blood; D019820:Xanthine / Q000097:blood
chemical_list: D015415:Biomarkers; D011687:Purines; D019820:Xanthine; D014527:Uric Acid; D007288:Inosine; D000241:Adenosine