title: Discovery and development of the anticancer agent salinosporamide A (NPI-0052).
abstract: The discovery of the anticancer agent salinosporamide A (NPI-0052) resulted from the exploration of new marine environments and a commitment to the potential of the ocean to yield new natural products for drug discovery and development. Driving the success of this process was the linkage of academic research together with the ability and commitment of industry to undertake drug development and provide the resources and expertise to advance the entry of salinosporamide A (NPI-0052) into human clinical trials. This paper offers a chronicle of the important events that facilitated the rapid clinical development of this exciting molecule.
authors.affiliation: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093-0204, USA.
authors.forename: William
authors.initials: W
authors.lastname: Fenical
authors.forename: Paul R
authors.initials: PR
authors.lastname: Jensen
authors.forename: Michael A
authors.initials: MA
authors.lastname: Palladino
authors.forename: Kin S
authors.initials: KS
authors.lastname: Lam
authors.forename: G Kenneth
authors.initials: GK
authors.lastname: Lloyd
authors.forename: Barbara C
authors.initials: BC
authors.lastname: Potts
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D055808:Drug Discovery; D015507:Drugs, Investigational; D007783:Lactones / Q000737:chemistry*; D015394:Molecular Structure; D011758:Pyrroles / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D015507:Drugs, Investigational; D007783:Lactones; D011758:Pyrroles; C475865:marizomib