Cytotoxic prenylated xanthones from Calophyllum inophyllum.
A new prenylated xanthone (1), named caloxanthone N, together with two known constituents, gerontoxanthone C (2) and 2-hydroxyxanthone (3), was isolated from the ethanolic extract of the twigs of Calophyllum inophyllum. Their structures were completely elucidated using a combination of 1D, 2D NMR techniques (COSY, HMQC, HMBC, and ROESY) and HR-ESI-MS analyses. Compounds 1 and 2 exhibited cytotoxicity against chronic myelogenous leukemia cell line (K562) with IC50 values of 7.2 and 6.3 microg ml(- 1), respectively.
Xiao
Qi
Q
Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China.
Zeng
Yan-Bo
YB
Mei
Wen-Li
WL
Zhao
You-Xing
YX
Deng
Yuan-Yuan
YY
Dai
Hao-Fu
HF
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D029759:Calophyllum / Q000737:chemistry*; D015394:Molecular Structure; D044004:Xanthones / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D044004:Xanthones