Helicobacter pylori infection as a risk factor for insulin resistance.
This study aimed to determine the relation between Helicobacter pylori infection and insulin resistance in healthy subjects. In a cross-sectional case control study between January and April 2007, a total of 71 healthy subjects without the exclusion criteria completed the study. Forty-three (60.6%) patients were H. pylori positive and 28 (39.4%) patients were H. pylori negative. Age and body mass index of the patients were not significantly different between the two groups (32.2 +/- 14.2 vs. 33 +/- 8.05 years and 23.15 +/- 4.5 vs. 24.04 +/- 3.2 kg/m(2), respectively). H-pylori-positive patients had significantly higher HOMA-IR level compared to H-pylori-negative patients (3.54 +/- 2.2 vs. 2.46 +/- 1.9, respectively) (P < 0.05). Fasting serum insulin level was significantly higher in the H-pylori-positive group compared with the H-pylori-negative group (19.41 +/- 3.08 vs. 16.57 +/- 2.02 microU/ml, respectively) (P < 0.05). Our findings suggest recognition of H. pylori infection as a risk factor for insulin resistance.
Eshraghian
Ahad
A
Internal Medicine Department, Jahrom University of Medical Sciences, Jahrom, Fars Province, Iran. Eshraghiana@yahoo.com
Hashemi
Seyed Ali
SA
Hamidian Jahromi
Alireza
A
Eshraghian
Hamed
H
Masoompour
Seyed Masoum
SM
Davarpanah
Mohamad Ali
MA
Eshraghian
Kavus
K
Taghavi
Seyed Alireza
SA
D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D016481:Helicobacter Infections / Q000503:physiopathology*; D016480:Helicobacter pylori / Q000276:immunology; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D055815:Young Adult
D000907:Antibodies, Bacterial