Identification of 19-epi-okadaic acid, a new diarrhetic shellfish poisoning toxin, by liquid chromatography with mass spectrometry detection.
Okadaic acid (1) (OA) and its congeners are mainly responsible for diarrhetic shellfish poisoning (DSP) syndrome. The presence of several OA derivatives have already been confirmed in Prorocentrum and Dinophysis spp. In this paper, we report on the detection and identification of a new DSP toxin, the OA isomer 19-epi-okadaic acid (2) (19-epi-OA), isolated from cultures of Prorocentrum belizeanum, by determining its retention time (RT) and fragmentation pattern using liquid chromatography coupled with mass spectrometry (LC-MS/MS).
Paz
Beatriz
B
Fitoplancton Tóxico, Instituto de Investigaciones Marinas (CSIC), Eduardo Cabello 6, 36080 Vigo, Spain. beatriz.paz@vi.ieo.es
Daranas
Antonio H
AH
Cruz
Patricia G
PG
Franco
José M
JM
Norte
Manuel
M
Fernández
José J
JJ
D000818:Animals; D002853:Chromatography, Liquid; D003967:Diarrhea / Q000139:chemically induced*; D004141:Dinoflagellida / Q000737:chemistry*; D005517:Foodborne Diseases; D013058:Mass Spectrometry; D008958:Models, Molecular; D015394:Molecular Structure; D019319:Okadaic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000633:toxicity; D012758:Shellfish / Q000032:analysis*
C522300:19-epi-okadaic acid; D019319:Okadaic Acid