title: Risk factors of long-term incidences of thrombosis, myelofibrosis and evolution into malignance in polycythemia vera: a single center experience from China.
abstract: To find out risk factors of incidences of long-term complications of thrombosis, myelofibrosis with myeloid metaplasia (MMM) and evolution into malignance in Chinese PV patients, we evaluated 320 PV patients referred to our center from April 1984 to June 2005 by Kaplan-Meier estimation and Cox proportional hazards models. A total of 250 events of thrombosis were observed in 138 (43.13%) patients. Advanced age, prior thrombosis and hemoglobin out of control were statistically significant risk factors of incidences of thrombotic events. A total of 43 patients progressed into MMM at a median time of 84 (7-240) months, higher white blood cell (WBC) count, splenomegaly, receiving alkylating agent and hydroxycarbamide were associated with the progression into MMM. During the follow-up time, 11 and 2 patients died of fatal complications of thrombosis and acute myeloid leukaemia (AML), respectively. These results suggest that advanced age, prior thrombosis and hemoglobin out of control contributed to relatively high incidence of thromboembolism; higher WBC count, splenomegaly, receiving alkylating agent and hydroxycarbamide were risk factors of evolution to MMM. The main poor factors that influenced the survival of Chinese PV patients were incidences of thromboembolism and evolution into AML.
authors.affiliation: Polycythemia Vera Studying Program, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Science and Peking Union Medical College, 288 Nanjing Road, 300020, Tianjin, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Bai
authors.affiliation: Polycythemia Vera Studying Program, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Science and Peking Union Medical College, 288 Nanjing Road, 300020, Tianjin, People's Republic of China.
authors.forename: Yangping
authors.initials: Y
authors.lastname: Xue
authors.affiliation: Polycythemia Vera Studying Program, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Science and Peking Union Medical College, 288 Nanjing Road, 300020, Tianjin, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Ye
authors.affiliation: Polycythemia Vera Studying Program, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Science and Peking Union Medical College, 288 Nanjing Road, 300020, Tianjin, People's Republic of China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Yao
authors.affiliation: Polycythemia Vera Studying Program, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Science and Peking Union Medical College, 288 Nanjing Road, 300020, Tianjin, People's Republic of China.
authors.forename: Chunlin
authors.initials: C
authors.lastname: Zhou
authors.affiliation: Polycythemia Vera Studying Program, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Science and Peking Union Medical College, 288 Nanjing Road, 300020, Tianjin, People's Republic of China.
authors.forename: Zonghong
authors.initials: Z
authors.lastname: Shao
authors.affiliation: Polycythemia Vera Studying Program, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Science and Peking Union Medical College, 288 Nanjing Road, 300020, Tianjin, People's Republic of China.
authors.forename: Linsheng
authors.initials: L
authors.lastname: Qian
authors.affiliation: Polycythemia Vera Studying Program, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Science and Peking Union Medical College, 288 Nanjing Road, 300020, Tianjin, People's Republic of China.
authors.forename: Renchi
authors.initials: R
authors.lastname: Yang
authors.affiliation: Polycythemia Vera Studying Program, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Science and Peking Union Medical College, 288 Nanjing Road, 300020, Tianjin, People's Republic of China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Li
authors.affiliation: Polycythemia Vera Studying Program, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Science and Peking Union Medical College, 288 Nanjing Road, 300020, Tianjin, People's Republic of China.
authors.forename: Hongyun
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Polycythemia Vera Studying Program, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Science and Peking Union Medical College, 288 Nanjing Road, 300020, Tianjin, People's Republic of China. zheng_yizhou@hotmail.com.
authors.forename: Yizhou
authors.initials: Y
authors.lastname: Zheng
mesh_terms: D000328:Adult; D000367:Age Factors; D002681:China; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000188:drug therapy / Q000209:etiology / Q000401:mortality*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D011087:Polycythemia Vera / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000401:mortality*; D055728:Primary Myelofibrosis / Q000097:blood / Q000188:drug therapy / Q000209:etiology / Q000401:mortality*; D012189:Retrospective Studies; D012307:Risk Factors; D013923:Thromboembolism / Q000097:blood / Q000188:drug therapy / Q000209:etiology / Q000401:mortality*