title: Histidine at codon 154 of the prion protein gene is a risk factor for Nor98 scrapie in goats.
abstract: Prion protein gene (PRNP) polymorphisms are involved in modulating the appearance of atypical/Nor98 scrapie in sheep, with the alleles AHQ and AF141RQ strongly associated with occurrence of the disease. The presence of histidine at codon 154 has also been detected in Nor98-affected goats, but statistical analysis of the association between Nor98 and goat PRNP polymorphisms has not been reported previously. Here, a case-control study was carried out on eight Nor98-positive goats and 246 negative herdmates belonging to eight Italian Nor98 scrapie outbreaks. The results revealed that histidine at codon 154 is also strongly associated with the disease in goats.
authors.affiliation: Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Via Bologna 148, Torino, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Colussi
authors.affiliation: Istituto Superiore di Sanità, Viale Regina Elena 299, Rome, Italy.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Vaccari
authors.affiliation: Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Via Bologna 148, Torino, Italy.
authors.forename: Cristiana
authors.initials: C
authors.lastname: Maurella
authors.affiliation: Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Via Bologna 148, Torino, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Bona
authors.affiliation: Istituto Zooprofilattico Sperimentale delle Regioni Lazio Toscana, Via Appia Nuova 1411, Rome, Italy.
authors.forename: Raniero
authors.initials: R
authors.lastname: Lorenzetti
authors.affiliation: Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata, Via Manfredoni 20, Foggia, Italy.
authors.forename: Pasquale
authors.initials: P
authors.lastname: Troiano
authors.affiliation: Istituto Zooprofilattico Sperimentale del Mezzogiorno, Via Crotone, Catanzaro, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Casalinuovo
authors.affiliation: Istituto Zooprofilattico Sperimentale del Mezzogiorno, Via Fanelli P.co dei Gerani, Caserta, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Di Sarno
authors.affiliation: Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Via Bologna 148, Torino, Italy.
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Maniaci
authors.affiliation: Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Via Bologna 148, Torino, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Zuccon
authors.affiliation: Istituto Superiore di Sanità, Viale Regina Elena 299, Rome, Italy.
authors.forename: Romolo
authors.initials: R
authors.lastname: Nonno
authors.affiliation: Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Via Bologna 148, Torino, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Casalone
authors.affiliation: Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Via Bologna 148, Torino, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Mazza
authors.affiliation: Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Via Bologna 148, Torino, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ru
authors.affiliation: Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Via Bologna 148, Torino, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Caramelli
authors.affiliation: Istituto Superiore di Sanità, Viale Regina Elena 299, Rome, Italy.
authors.forename: Umberto
authors.initials: U
authors.lastname: Agrimi
authors.affiliation: Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Via Bologna 148, Torino, Italy.
authors.forename: Pier Luigi
authors.initials: PL
authors.lastname: Acutis
mesh_terms: D000818:Animals; D016022:Case-Control Studies; D003062:Codon / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015511:Goat Diseases / Q000235:genetics*; D006041:Goats; D006639:Histidine / Q000235:genetics*; D009154:Mutation; D011110:Polymorphism, Genetic; D011328:Prions / Q000235:genetics*; D012307:Risk Factors; D012608:Scrapie / Q000235:genetics*
chemical_list: D003062:Codon; D011328:Prions; D006639:Histidine