Central or peripheral norepinephrine depletion enhances MK-801-induced plasma corticosterone level in mice.
To investigate the involvement of central or peripheral catecholaminergic systems in the MK-801-induced increase in plasma corticosterone and interleukin-6 levels, we pretreated mice either intracerebroventricularly (i.c.v.) or intraperitoneally (i.p.) with 6-hydroxydopamine (6-OHDA) which depletes catecholamines. Pretreatment of animals with 6-OHDA (50 microg i.c.v. or 100 mg/kg i.p.) significantly enhanced the MK-801 (1 microg i.c.v.)-induced increase in plasma corticosterone level. On the other hand, pretreatment of mice with 6-OHDA (50 microg i.c.v. or 100 mg/kg i.p.) did not affect the MK-801 (1 microg i.c.v.)-induced increase in plasma IL-6 level. These results suggest that central and peripheral catecholaminergic systems are involved in the suppressive regulation of MK-801-induced plasma corticosterone level.
Kim
Do-Hoon
DH
Department of Psychiatry, College of Medicine, Hallym University, Chunchon, Gangwon-Do, 200-702, South Korea. dohkim@hallym.ac.kr
Jung
Jun-Sub
JS
Moon
Yoo-Sun
YS
Song
Dong-Keun
DK
D000818:Animals; D001921:Brain / Q000187:drug effects*; D003345:Corticosterone / Q000097:blood*; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D007031:Hypothalamus / Q000378:metabolism; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009638:Norepinephrine / Q000378:metabolism*; D016627:Oxidopamine / Q000008:administration & dosage; D013154:Spleen / Q000378:metabolism
D015850:Interleukin-6; D016291:Dizocilpine Maleate; D016627:Oxidopamine; D003345:Corticosterone; D009638:Norepinephrine