Prevalence of metabolic syndrome and obesity in renal transplanted Mexican children.
The purpose of the study was to evaluate the prevalence of MS and obesity in Mexican children with more than one yr post-renal transplantation. Thirty-two children transplanted between January 2004 and February 2006 were included in the study. The weight and height at the time of renal transplant were obtained. A fasting blood sample was drawn for serum creatinine, adiponectin, and complete lipid profile, and a three-h glucose tolerance test was also taken. A complete nutritional evaluation was performed including anthropometry. There was a statistically significant increase in BMI at one yr post-transplant that was maintained at two yr post-transplant. Three patients exhibited obesity and were overweight. Seventeen patients had hypertension, 14 patients had low HDL, 12 patients had hypertriglyceridemia, all had normal fasting glucose, six of them had glucose intolerance, and two had waist circumference higher than 90%. Eight patients (25%) had MS. Patients with MS had higher proportion of deceased donor grafts, acute rejection episodes, and received more methylprednisolone pulses; also they had a statistically significant higher pretransplant BMI than patients without MS. There was a significant relationship between BMI at one yr post-renal transplant and creatinine clearance estimated by Schwartz formula.
Ramirez-Cortes
Guadalupe
G
Departamento de Nefrologia, Hospital Infantil de Mexico Federico Gomez, Mexico D.F., Mexico.
Fuentes-Velasco
Yolanda
Y
García-Roca
Pilar
P
Guadarrama
Omar
O
López
Mónica
M
Valverde-Rosas
Saúl
S
Velásquez-Jones
Luis
L
Romero
Benjamin
B
Toussaint
Georgina
G
Medeiros
Mara
M
D052242:Adiponectin / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D001835:Body Weight; D002648:Child; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000150:complications; D005260:Female; D006801:Humans; D006973:Hypertension / Q000628:therapy; D007674:Kidney Diseases / Q000150:complications / Q000628:therapy*; D016030:Kidney Transplantation; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000453:epidemiology*; D008800:Mexico; D009765:Obesity / Q000150:complications* / Q000453:epidemiology*; D050177:Overweight; D015995:Prevalence
D052242:Adiponectin