title: The polymorphism IL-1beta T-31C is associated with a longer overall survival in patients with multiple myeloma undergoing auto-SCT.
abstract: Proinflammatory cytokines are suspected to play a role in the pathogenesis of multiple myeloma (MM). Therefore, it is possible that inborn genetic variations leading to a modified expression of these cytokines will influence the outcome for these patients. We investigated 348 MM patients undergoing high-dose melphalan treatment followed by Auto-SCT and examined the influence of single nucleotide polymorphisms (SNPs) in genes involved in the inflammatory response. We found that the polymorphism IL-1beta T-31C significantly influenced overall survival (OS; P=0.02) and that carriers of the variant C-allele had a significantly longer survival than homozygous wild-type allele TT-carriers (relative risk 0.6 (95% CI=0.5-0.9); P=0.008). The polymorphisms IL-6 G-174C, IL-10 C592A, PPARgamma2 Pro(12)Ala, COX-2 A-1195G, COX-2 T8473C and NFKB1 ins/del did not influence the OS in this group of patients. Furthermore, homozygous carriers of the variant allele of IL-1beta T-31C were at 1.37-fold (CI=1.05-1.80) increased risk of MM as compared with population-based controls (P=0.02). Our results indicate that IL-1beta is involved in the pathogenesis of MM.
authors.affiliation: Department of Oncology and Hematology, Roskilde County Hospital, Roskilde, Denmark. avag@regionsjaelland.dk
authors.forename: A J
authors.initials: AJ
authors.lastname: Vangsted
authors.forename: T W
authors.initials: TW
authors.lastname: Klausen
authors.forename: W
authors.initials: W
authors.lastname: Ruminski
authors.forename: P
authors.initials: P
authors.lastname: Gimsing
authors.forename: N F
authors.initials: NF
authors.lastname: Andersen
authors.forename: A O
authors.initials: AO
authors.lastname: Gang
authors.forename: N
authors.initials: N
authors.lastname: Abildgaard
authors.forename: L M
authors.initials: LM
authors.lastname: Knudsen
authors.forename: J L
authors.initials: JL
authors.lastname: Nielsen
authors.forename: H
authors.initials: H
authors.lastname: Gregersen
authors.forename: U
authors.initials: U
authors.lastname: Vogel
mesh_terms: D000368:Aged; D005260:Female; D006239:Haplotypes; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics*; D015999:Multivariate Analysis; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D033581:Stem Cell Transplantation; D016019:Survival Analysis; D014182:Transplantation, Autologous
chemical_list: D053583:Interleukin-1beta