Severe encephalomyelitis in an immunocompetent adult with chromosomally integrated human herpesvirus 6 and clinical response to treatment with foscarnet plus ganciclovir.
Human herpesvirus 6 has rarely been identified as a cause of encephalitis in immunocompetent adults. We describe a patient who had severe encephalomyelitis, hypoglycorrhachia, and human herpesvirus 6 identified in his cerebrospinal fluid and serum and who recovered after treatment with foscarnet and ganciclovir. Human herpesvirus 6 should be considered in immunocompetent patients with encephalitis.
Troy
Stephanie B
SB
Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California 94305-5107, USA. sbtroy@stanford.edu
Blackburn
Brian G
BG
Yeom
Kristen
K
Caulfield
Anna K Finley
AK
Bhangoo
Munveer S
MS
Montoya
Jose G
JG
D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D002555:Cerebrospinal Fluid / Q000821:virology; D004679:Encephalomyelitis / Q000188:drug therapy* / Q000821:virology*; D017245:Foscarnet / Q000627:therapeutic use*; D015774:Ganciclovir / Q000627:therapeutic use*; D015654:Herpesvirus 6, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D011533:Proviruses / Q000235:genetics / Q000302:isolation & purification*; D019349:Roseolovirus Infections / Q000188:drug therapy* / Q000821:virology*; D044967:Serum / Q000821:virology; D016896:Treatment Outcome
D000998:Antiviral Agents; D017245:Foscarnet; D015774:Ganciclovir