title: BTB/POZ domain of speckle-type POZ protein (SPOP) confers proapoptotic function in HeLa cells.
abstract: The proapoptotic function of SPOP protein was investigated in HeLa cells. HeLa cells underwent apoptosis by the overexpression of SPOP. Studies using SPOP deletion mutants suggest that BTB/POZ domain of SPOP protein is important for the induction of apoptosis in transfected cells. This study first proposes the proapoptotic aspect of the BTB/POZ domain of SPOP protein based on the finding that cells expressing the C-terminal fragment of SPOP containing the BTB/POZ domain underwent apoptosis.
authors.affiliation: Department of Oriental Medicine, Daegu Haany University, Daegu, South Korea. bhbyun@dhu.ac.kr
authors.forename: Boohyeong
authors.initials: B
authors.lastname: Byun
authors.forename: Heejae
authors.initials: H
authors.lastname: Tak
authors.forename: Cheol O
authors.initials: CO
authors.lastname: Joe
mesh_terms: D017209:Apoptosis / Q000235:genetics / Q000502:physiology*; D001665:Binding Sites / Q000235:genetics / Q000502:physiology; D015153:Blotting, Western; D006367:HeLa Cells; D006801:Humans; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D014162:Transfection
chemical_list: D009687:Nuclear Proteins; D012097:Repressor Proteins; C509761:SPOP protein, human