[Neuroprotection using hypothermia after perinatal asphyxia in full-term neonates].
Randomised controlled trials have demonstrated that mild hypothermia reduces mortality and morbidity in full-term neonates who experience perinatal asphyxia. Hypothermia can be applied to the head or entire body, maintaining a temperature of 33-34 degrees C for 72 hours. Treatment should be started within 6 hours after birth. An estimated 180-200 neonates may be eligible for this novel approach to neuroprotection each year in the Netherlands.
Groenendaal
F
F
Universitair Medisch Centrum Utrecht, locatie Wilhelmina Kinderzie-kenhuis, afd. Neonatologie, kamer KE 04.123.1, Lundlaan 6, 3584 EA Utrecht. f.groenendaal@umcutrecht.nl
Hukkelhoven
C W P M
CW
de Vries
L S
LS
van Bel
F
F
D001238:Asphyxia Neonatorum / Q000401:mortality / Q000628:therapy*; D006257:Head / Q000502:physiology; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D002534:Hypoxia, Brain / Q000628:therapy*; D020925:Hypoxia-Ischemia, Brain / Q000401:mortality / Q000628:therapy*; D007231:Infant, Newborn; D008991:Monitoring, Physiologic / Q000379:methods; D017694:Rewarming / Q000379:methods; D016896:Treatment Outcome