title: Elevated serum C-reactive protein levels predict cardiovascular events in the Japanese coronary artery disease (JCAD) study.
abstract: BACKGROUND
  Accumulating evidence indicates that C-reactive protein (CRP) is an independent predictive factor for atherosclerotic vascular disease in Caucasians. Accordingly, this study sought to investigate the relationship between the serum level of CRP and cardiovascular events of Japanese patients with coronary artery disease (CAD).
  
  
  RESULTS
  The Japanese CAD (JCAD) study enrolled 15,628 patients who had significant diameter stenosis (>or=75%) in at least 1 coronary artery. Of these, 6,802 patients had their baseline serum CRP data available. Patients were followed up for a mean of 2.7 years (follow-up rate 88.3%). The primary endpoint of the JCAD study was all events. Baseline covariates possibly influencing the event rate were adjusted between the 2 groups with and without elevated serum CRP level. Kaplan-Meier analysis demonstrated a 30% higher all-events rate in patients with a serum level of CRP >or=0.1 mg/dl (P=0.0002). Cox proportional hazard analysis also showed that a serum level of CRP >or=0.1 mg/dl was an independent predictor of all events (P=0.0001), and of cardiac events and cardiac death (P=0.0005).
  
  
  CONCLUSIONS
  Elevated serum level of CRP is an independent predictor of cardiovascular events in JCAD patients.
authors.affiliation: Department of Cardiology, Osaka Ekisaikai Hospital, Osaka, Japan.
authors.forename: Kenei
authors.initials: K
authors.lastname: Shimada
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Fujita
authors.forename: Atsushi
authors.initials: A
authors.lastname: Tanaka
authors.forename: Ken
authors.initials: K
authors.lastname: Yoshida
authors.forename: Satoshi
authors.initials: S
authors.lastname: Jisso
authors.forename: Hidemasa
authors.initials: H
authors.lastname: Tanaka
authors.forename: Junichi
authors.initials: J
authors.lastname: Yoshikawa
authors.forename: Takahide
authors.initials: T
authors.lastname: Kohro
authors.forename: Doubun
authors.initials: D
authors.lastname: Hayashi
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Okada
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Yamazaki
authors.forename: Ryozo
authors.initials: R
authors.lastname: Nagai
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000150:complications / Q000208:ethnology*; D005260:Female; D005500:Follow-Up Studies; D006323:Heart Arrest / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D006333:Heart Failure / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D006801:Humans; D007564:Japan; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors
chemical_list: D002097:C-Reactive Protein