Serum and synovial fluid leptin levels and markers of inflammation in rheumatoid arthritis.
This study was designed to investigate the serum and synovial fluid leptin levels, and inflammatory markers in rheumatoid arthritis (RA) patients. Serum and synovial fluid leptin levels were significantly higher (P > 0.05) in RA patients than control group; RA patients with moderate disease activity (DAS < 2.7) having significantly higher leptin levels (P > 0.05) than those with low disease activity (DAS < 2.7). Leukocytes and erythrocyte sedimentation rate (ESR) were found to be significantly higher in moderate disease activity RA group compared to low activity group (P > 0.05, P < 0.001, respectively). Serum leptin level is found to be independent of age and inflammatory markers. ESR is positively correlated with DAS activity and CRP values. Our finding of no correlation between leptin and BMI shows that regulation of leptinemia is complex, and leptin levels cannot be used to assess RA activity.
Seven
Arzu
A
Cerrahpaşa Medical Faculty, Istanbul University, Istanbul, Turkey. arzu_seven@hotmail.com
Güzel
Savaş
S
Aslan
Mahmure
M
Hamuryudan
Vedat
V
D000328:Adult; D000367:Age Factors; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000276:immunology / Q000503:physiopathology*; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D001799:Blood Sedimentation; D015992:Body Mass Index; D002634:Chemotaxis, Leukocyte / Q000276:immunology; D016207:Cytokines / Q000032:analysis / Q000097:blood*; D004912:Erythrocytes / Q000276:immunology / Q000378:metabolism; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000032:analysis / Q000097:blood*; D007596:Joints / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D020738:Leptin / Q000032:analysis / Q000097:blood*; D007962:Leukocytes / Q000276:immunology / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000276:immunology / Q000378:metabolism; D011237:Predictive Value of Tests; D013582:Synovial Fluid / Q000276:immunology / Q000378:metabolism*; D015854:Up-Regulation / Q000276:immunology
D015415:Biomarkers; D016207:Cytokines; D018836:Inflammation Mediators; D020738:Leptin