title: Inhibitory effect of macabarterin, a polyoxygenated ellagitannin from Macaranga barteri, on human neutrophil respiratory burst activity.
abstract: An ellagitannin with a 2,4-acyl group, named macabarterin (1), and a new ellagic acid glycoside, 3-O-methylellagic acid 4-O-β-d-xylopyranoside (2), were isolated from the stem bark extract of Macaranga barteri along with five known phenolic compounds, ellagic acid (3), 3-O-methylellagic acid (4), gallic acid (5), methyl gallate (6), and scopoletin (7). The structures of 1 and 2, as well as those of the known compounds, were elucidated on the basis of spectroscopic data and by comparison with reported data. Compounds 1-5 and 7 were tested for their anti-inflammatory potential in a cell-based respiratory burst assay, compound 1 being found an inhibitor of the superoxides produced in the cellular system.
authors.affiliation: Department of Organic Chemistry, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon. monordr@yahoo.com
authors.forename: Rostand Manfouo
authors.initials: RM
authors.lastname: Ngoumfo
authors.forename: Georges Eric
authors.initials: GE
authors.lastname: Ngounou
authors.forename: Chimene Victoire
authors.initials: CV
authors.lastname: Tchamadeu
authors.forename: Muhammad Irfan
authors.initials: MI
authors.lastname: Qadir
authors.forename: Celine Djama
authors.initials: CD
authors.lastname: Mbazoa
authors.forename: Afshan
authors.initials: A
authors.lastname: Begum
authors.forename: Fernande Ngounou
authors.initials: FN
authors.lastname: Ngninzeko
authors.forename: David
authors.initials: D
authors.lastname: Lontsi
authors.forename: Muhammad Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002163:Cameroon; D004610:Ellagic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D019665:Euphorbiaceae / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D047348:Hydrolyzable Tannins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects; D024301:Plant Bark / Q000737:chemistry; D016897:Respiratory Burst / Q000187:drug effects*
chemical_list: C534594:3'-O-methylellagic acid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D006027:Glycosides; D047348:Hydrolyzable Tannins; C013515:ellagitannin; C567995:macabarterin; D004610:Ellagic Acid