title: Effective chemotherapy based on a chemosensitivity test for malignant pleural mesothelioma.
abstract: Malignant pleural mesothelioma (MPM) is an aggressive and fatal tumor of the pleura and its incidence has been increasing as a result of the widespread use of asbestos worldwide. Numerous chemotherapeutic agents have been tested in many clinical trials, but the response rate does not exceed 20% for most of the investigated regimens. Here we report a case of MPM in which the chemotherapy based on the chemosensitivity test was very effective on palliation with stable disease for a long time.
authors.affiliation: Divisions of Thoracic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Maniwa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yoshimura
authors.forename: Masahiko
authors.initials: M
authors.lastname: Takata
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Nishimura
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Ohno
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology / Q000627:therapeutic use*; D049109:Cell Proliferation / Q000187:drug effects; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008654:Mesothelioma / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D009367:Neoplasm Staging; D010166:Palliative Care; D018579:Patient Selection; D010997:Pleural Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014407:Tumor Cells, Cultured; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives; D000077235:Vinorelbine; D000093542:Gemcitabine
chemical_list: D003841:Deoxycytidine; D014747:Vinblastine; D000077235:Vinorelbine; D000093542:Gemcitabine