Pregnancy-associated breast cancer.
The frequency of pregnancy-associated breast cancer, a rare but serious occurrence, may increase in light of the secular trends for lower parity in general and for older age at first full-term delivery in particular Data on PABC in individuals who are at high risk for breast cancer are limited. A computerized search of Pubmed showed that the reported incidence of PABC is 1:3000 pregnancies; it is often diagnosed at an advanced stage and its prognosis is inferior compared to non-PABC Carriers of mutations in the genes BRCA1/2 may present a specific high risk group for PABC especially at younger ages. Women treated with fertility treatment drugs may be at a higher risk for PABC as well.
Keinan-Boker
Lital
L
Israel Center for Disease Control, Ministry of Health, Sheba Medical Center of Health Policy Research, Tel Hashomer, Israel. lkeinan@univ.haifa.ac.il
Lerner-Geva
Liat
L
Kaufman
Bella
B
Meirow
Dror
D
D024682:BRCA2 Protein / Q000235:genetics; D001943:Breast Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D014943:Global Health; D006801:Humans; D015994:Incidence; D009154:Mutation; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic; D011379:Prognosis; D012307:Risk Factors; D015996:Survival Rate; D044767:Ubiquitin-Protein Ligases / Q000235:genetics
D024682:BRCA2 Protein; D004273:DNA, Neoplasm; C111164:BRAP protein, human; D044767:Ubiquitin-Protein Ligases