title: [Preparation of self-microemulsifying soft capsule and investigation of dissolution for Duyiwei].
abstract: OBJECTIVE
  To prepare the self-microemulsifying soft capsule (SMESC) of Duyiwei and investigate its dissolution property.
  
  
  METHODS
  Through solubility experiment, self-microemulsification in vitro, drawing phase diagram and investigating the stability of solution, the optimum formulation was determined for Duyiwei. The dissolution of SMESC was measured, taking the commercial capsule as reference.
  
  
  RESULTS
  In the optimum formulation, Labrasol, Transcutol P and ethyl oleate were screened as emulsifier, co-emulsifier and oil phase, respectively. The optimized proportion was 60: 25: 15. The dissolution of SMESC in water was more than 85% in 10 minutes, while that of the commercial capsule was less than 50% in 60 minutes.
  
  
  CONCLUSIONS
  In comparison with the commercial capsule, the dissolution of SMESC is sufficiently improved in water.
authors.affiliation: Guangdong Pharmaceutical University, Guangzhou 510006, China.
authors.forename: Sheng-Miao
authors.initials: SM
authors.lastname: Cui
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Shen
mesh_terms: D002214:Capsules; D004339:Drug Compounding; D016503:Drug Delivery Systems; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry*; D004655:Emulsions; D019686:Lamiaceae / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D012995:Solubility; D013501:Surface-Active Agents; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D002214:Capsules; D004365:Drugs, Chinese Herbal; D004655:Emulsions; D013501:Surface-Active Agents