title: Successful management of a delayed and persistent cutaneous reaction  to jellyfish with pimecrolimus.
abstract: The contact with a jellyfish is usually followed by acute inflammatory lesions, characterized by erythema, swelling, vesicles, and bullae, accompanied by burning and pain sensation. The pathogenesis is due to the direct toxic effect of the fluid contained in jellyfish tentacles. Sometimes, jellyfish may induce delayed cutaneous lesions. Delayed cutaneous reaction to jellyfish represents a clinical entity where eczematous lesions develop after days or months after contact with the invertebrate. We report the case of a patient with a delayed and persistent skin reaction due to jellyfish envenomation successfully treated with pimecrolimus.
authors.affiliation: Department of Dermatology, University of Naples Federico II, Naples, Italy.
authors.forename: Luisa
authors.initials: L
authors.lastname: Di Costanzo
authors.forename: Nicola
authors.initials: N
authors.lastname: Balato
authors.forename: Orlando
authors.initials: O
authors.lastname: Zagaria
authors.forename: Anna
authors.initials: A
authors.lastname: Balato
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000818:Animals; D001733:Bites and Stings; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D007868:Leg Dermatoses / Q000175:diagnosis / Q000209:etiology; D018570:Risk Assessment; D037401:Scyphozoa; D012720:Severity of Illness Index; D012882:Skin Tests; D016559:Tacrolimus / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: C117268:pimecrolimus; D016559:Tacrolimus