title: Apoptosis resistance in tumor cells.
abstract: Various antitumor agents induce apoptotic cell death in tumor cells. Since the apoptosis program in tumor cells plays a critical role in the chemotherapy-induced tumor cell killing, it is suggested that the defect in the signaling pathway of apoptosis could cause a new form of multidrug resistance in tumor cells. This article describes the recent findings concerning the mechanisms of chemotherapy-induced apoptosis and discusses the implication of apoptosis resistance in cancer chemotherapy.
authors.affiliation: Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo, 113, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Mashima
authors.forename: H
authors.initials: H
authors.lastname: Seimiya
authors.forename: Z
authors.initials: Z
authors.lastname: Chen
authors.forename: S
authors.initials: S
authors.lastname: Kataoka
authors.forename: T
authors.initials: T
authors.lastname: Tsuruo