title: Liver transplantation for hepatocellular carcinoma with intrahepatic lymphatic invasion: case reports.
abstract: Multiple studies addressing liver transplantation (OLT) for hepatocellular carcinoma (HCC) have identified various prognostic determinants of tumor recurrence and decreased patient survival. However, little information is available on the impact of intrahepatic lymphatic invasion on tumor recurrence and survival after OLT for HCC. Intrahepatic lymphatic invasion was observed in 1.4% (n = 2) of liver explants with HCC in our series. Both recipients are alive without tumor recurrence at 16 and 39 months post-OLT, respectively. Intrahepatic lymphatic invasion may not be an absolute adverse prognostic factor in cases of HCC with no hilar lymph node involvement at the time of OLT.
authors.affiliation: Department of General, Visceral, and Transplantation Surgery, University Hospital Essen, Essen, Germany; Department of General and Abdominal Surgery, Johannes Gutenberg University Hospital, Mainz, Germany. sotiropoulos@ach.klinik.uni-mainz.de
authors.forename: G C
authors.initials: GC
authors.lastname: Sotiropoulos
authors.forename: E P
authors.initials: EP
authors.lastname: Molmenti
authors.forename: I
authors.initials: I
authors.lastname: Fouzas
authors.forename: G
authors.initials: G
authors.lastname: Sgourakis
authors.forename: A
authors.initials: A
authors.lastname: Radtke
authors.forename: M
authors.initials: M
authors.lastname: Malagó
authors.forename: H
authors.initials: H
authors.lastname: Lang
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology* / Q000601:surgery*; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D016896:Treatment Outcome