title: Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population.
abstract: Several lines of evidence from animal and genetic analyses showed that the calcineurin A gamma subunit gene (PPP3CC) plays an important role in the pathogenesis of schizophrenia. Moreover, a recent large Japanese case-control study confirmed the genetic association of PPP3CC with schizophrenia. The symptoms of methamphetamine (MAP)-induced psychosis are similar to those of schizophrenia, suggesting that PPP3CC is an attractive candidate gene not only for schizophrenia, but also for METH-related disorders. In this study, we carried out a genetic association study of PPP3CC with MAP-use disorder in a Japanese population. We selected five haplotype-tagging SNPs from the aforementioned replication study and genotyped 393 samples (MAP abuse, 128; control, 265). We could not detect a significant association of all tagging SNPs with each condition. In conclusion, our data suggest that PPP3CC does not elevate the risk of MAP-use disorder in the Japanese population.
authors.affiliation: Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kinoshita
authors.forename: M
authors.initials: M
authors.lastname: Ikeda
authors.forename: H
authors.initials: H
authors.lastname: Ujike
authors.forename: T
authors.initials: T
authors.lastname: Kitajima
authors.forename: Y
authors.initials: Y
authors.lastname: Yamanouchi
authors.forename: B
authors.initials: B
authors.lastname: Aleksic
authors.forename: T
authors.initials: T
authors.lastname: Kishi
authors.forename: K
authors.initials: K
authors.lastname: Kawashima
authors.forename: T
authors.initials: T
authors.lastname: Ohkouchi
authors.forename: N
authors.initials: N
authors.lastname: Ozaki
authors.forename: T
authors.initials: T
authors.lastname: Inada
authors.forename: M
authors.initials: M
authors.lastname: Harano
authors.forename: T
authors.initials: T
authors.lastname: Komiyama
authors.forename: T
authors.initials: T
authors.lastname: Hori
authors.forename: M
authors.initials: M
authors.lastname: Yamada
authors.forename: Y
authors.initials: Y
authors.lastname: Sekine
authors.forename: M
authors.initials: M
authors.lastname: Iyo
authors.forename: I
authors.initials: I
authors.lastname: Sora
authors.forename: N
authors.initials: N
authors.lastname: Iwata
mesh_terms: D019969:Amphetamine-Related Disorders / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D019703:Calcineurin / Q000235:genetics*; D016022:Case-Control Studies; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008694:Methamphetamine / Q000494:pharmacology*; D020641:Polymorphism, Single Nucleotide; D011605:Psychoses, Substance-Induced / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics
chemical_list: D000697:Central Nervous System Stimulants; D008694:Methamphetamine; D019703:Calcineurin; C525675:PPP3CC protein, human