Delineation of an oral cancer lesion with swept-source optical coherence tomography.
We demonstrate the ex vivo imaging of an oral cancerous sample with a swept-source optical coherence tomography (SS-OCT) system. With the axial resolution of 8 microm in free space and system sensitivity of 108 dB, we can well distinguish the normal and abnormal tissue portions in a sample. In particular, we analyze the lateral variation of A-scan profiles to show two parameters of SS-OCT signal for delineating an oral cancer lesion. One of the parameters is the decay constant in the exponential fitting of the SS-OCT signal intensity along depth. This decay constant decreases as the A-scan point moves laterally across the margin of a lesion. The other parameter is the standard deviation of the SS-OCT signal intensity fluctuation in an A-scan. This parameter increases significantly when the A-scan point is moved across the transition region between the normal and abnormal portions. Such parameters are useful for determining the margins of oral cancer.
Tsai
Meng-Tsan
MT
National Taiwan University, Institute of Photonics and Optoelectronics, Department of Electrical Engineering, 1 Roosevelt Road, Section 4, Taipei, Taiwan.
Lee
Hsiang-Chieh
HC
Lu
Chih-Wei
CW
Wang
Yih-Ming
YM
Lee
Cheng-Kuang
CK
Yang
C C
CC
Chiang
Chun-Ping
CP
D000465:Algorithms; D001185:Artificial Intelligence; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D009062:Mouth Neoplasms / Q000473:pathology*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods*