title: Acute acalculous cholecystitis in children with Epstein-Barr virus infection: a role for Gilbert's syndrome?
abstract: Acute acalculous cholecystitis (AAC) in association with acute Epstein-Barr virus (EBV) infection has rarely been described in childhood. In the literature, there are only four reported pediatric cases of AAC associated with isolated primary EBV infection. We present two cases (one new, one retrospectively reviewed) of children with Gilbert's syndrome (GS) who presented with AAC during the course of primary EBV infection. Antibiotics were not used and AAC subsided gradually as the infection regressed. The co-occurrence of GS might have played a contributory role in the pathogenesis of AAC during acute EBV infection.
authors.affiliation: Department of Pediatrics, Athens Medical Center Hospital, Athens, Greece. attilakos@hotmail.com
authors.forename: Achilleas
authors.initials: A
authors.lastname: Attilakos
authors.forename: Alexia
authors.initials: A
authors.lastname: Prassouli
authors.forename: George
authors.initials: G
authors.lastname: Hadjigeorgiou
authors.forename: Evangelia
authors.initials: E
authors.lastname: Lagona
authors.forename: Sofia
authors.initials: S
authors.lastname: Kitsiou-Tzeli
authors.forename: Angeliki
authors.initials: A
authors.lastname: Galla
authors.forename: Anastasia
authors.initials: A
authors.lastname: Stasinopoulou
authors.forename: Themistocles
authors.initials: T
authors.lastname: Karpathios
mesh_terms: D042101:Acalculous Cholecystitis / Q000000981:diagnostic imaging*; D000208:Acute Disease; D002675:Child, Preschool; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D005260:Female; D005704:Gallbladder / Q000000981:diagnostic imaging; D005878:Gilbert Disease / Q000175:diagnosis*; D006801:Humans; D007244:Infectious Mononucleosis / Q000150:complications; D008297:Male; D014463:Ultrasonography