Nonthyroidal illness syndrome and euthyroid sick syndrome in intensive care patients.
This article reviews the pathophysiology of non-thyroidal illness syndrome (NTIS) and euthyroid sick syndrome (ESS), a multifactorial phenomenon characterized by suppression of thyroid hormone levels that has been described in several disease states, probably due to different causes in different patients. It also describes the laboratory values of thyroid function tests (TFTs), relevant animal studies, the association of NTIS and ESS with cardiovascular problems and sepsis, and the rationale for treatment.
Golombek
Sergio G
SG
The Regional Neonatal Center-Maria Fareri Children's Hospital at Westchester Medical Center/New York Medical College, Valhalla, New York 10595, USA. sergio_golombek@nymc.edu
D000818:Animals; D003422:Critical Care; D005067:Euthyroid Sick Syndromes / Q000097:blood / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D052577:Infant, Extremely Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D014284:Triiodothyronine; D013974:Thyroxine