title: Depot medroxyprogesterone acetate use after peak bone mass is associated with increased bone turnover but no decrease in bone mineral density.
abstract: OBJECTIVE
  To ascertain whether increased bone turnover in depot medroxyprogesterone acetate (DMPA) users after peak bone mass is associated with bone mineral loss.
  
  
  METHODS
  Three-year, observational, longitudinal study.
  
  
  METHODS
  General practice and family planning clinics.
  
  
  METHODS
  Women over age 34: established DMPA users (n = 23), discontinuers (n = 14), and controls (n = 27).
  
  
  METHODS
  Change in spine and hip bone mineral density (BMD).
  
  
  RESULTS
  Despite increased biochemical markers of bone turnover in DMPA users, there was no decrease in BMD. Bone turnover markers did not correlate with change in BMD.
  
  
  CONCLUSIONS
  In established DMPA users, after peak bone mass, a single normal BMD measurement could provide reassurance for long-term use. Measurement of bone turnover does not predict bone loss in DMPA users.
authors.affiliation: Academic Unit of Bone Metabolism, Northern General Hospital, Herries Road, Sheffield, S5 7AU, United Kingdom. jenniferwalsh@doctors.org.uk
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Walsh
authors.forename: Richard
authors.initials: R
authors.lastname: Eastell
authors.forename: Nicola F
authors.initials: NF
authors.lastname: Peel
mesh_terms: D000328:Adult; D000367:Age Factors; D015415:Biomarkers / Q000378:metabolism; D015519:Bone Density / Q000187:drug effects*; D016723:Bone Remodeling / Q000187:drug effects*; D003271:Contraceptive Agents, Female / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D005272:Femur Neck / Q000187:drug effects; D006801:Humans; D008137:Longitudinal Studies; D008159:Lumbar Vertebrae / Q000187:drug effects; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D011237:Predictive Value of Tests
chemical_list: D015415:Biomarkers; D003271:Contraceptive Agents, Female; D017258:Medroxyprogesterone Acetate