title: Stiff-person syndrome first manifesting in pregnancy.
abstract: Stiff-person syndrome (SPS) is a rare neurological disorder characterised by progressive stiffness and painful muscle spasms. We present a case of the autoimmune form of glutamate decarboxylase-positive SPS that initially manifested in pregnancy. The diagnosis was made based on clinical, laboratory and electromyoneurographic criteria. The patient was administered low doses of diazepam and baclofen. Considering the clinical picture of SPS patients, caesarean section is the method of choice for pregnancy termination.
authors.affiliation: Department of Neurology, Dubrovnik General Hospital, Dubrovnik, Croatia. deniscerimagic@yahoo.com
authors.forename: Denis
authors.initials: D
authors.lastname: Cerimagic
authors.forename: Ervina
authors.initials: E
authors.lastname: Bilic
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000175:diagnosis; D002585:Cesarean Section; D004576:Electromyography / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D005968:Glutamate Decarboxylase / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis* / Q000276:immunology / Q000601:surgery; D011256:Pregnancy Outcome; D011263:Pregnancy Trimester, Third; D035583:Rare Diseases; D018570:Risk Assessment; D016750:Stiff-Person Syndrome / Q000175:diagnosis* / Q000276:immunology* / Q000601:surgery; D005680:gamma-Aminobutyric Acid / Q000172:deficiency
chemical_list: D001323:Autoantibodies; D005680:gamma-Aminobutyric Acid; D005968:Glutamate Decarboxylase