Newly discovered ebola virus associated with hemorrhagic fever outbreak in Uganda.
Over the past 30 years, Zaire and Sudan ebolaviruses have been responsible for large hemorrhagic fever (HF) outbreaks with case fatalities ranging from 53% to 90%, while a third species, Côte d'Ivoire ebolavirus, caused a single non-fatal HF case. In November 2007, HF cases were reported in Bundibugyo District, Western Uganda. Laboratory investigation of the initial 29 suspect-case blood specimens by classic methods (antigen capture, IgM and IgG ELISA) and a recently developed random-primed pyrosequencing approach quickly identified this to be an Ebola HF outbreak associated with a newly discovered ebolavirus species (Bundibugyo ebolavirus) distantly related to the Côte d'Ivoire ebolavirus found in western Africa. Due to the sequence divergence of this new virus relative to all previously recognized ebolaviruses, these findings have important implications for design of future diagnostic assays to monitor Ebola HF disease in humans and animals, and ongoing efforts to develop effective antivirals and vaccines.
Towner
Jonathan S
JS
Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.
Sealy
Tara K
TK
Khristova
Marina L
ML
Albariño
César G
CG
Conlan
Sean
S
Reeder
Serena A
SA
Quan
Phenix-Lan
PL
Lipkin
W Ian
WI
Downing
Robert
R
Tappero
Jordan W
JW
Okware
Samuel
S
Lutwama
Julius
J
Bakamutumaho
Barnabas
B
Kayiwa
John
J
Comer
James A
JA
Rollin
Pierre E
PE
Ksiazek
Thomas G
TG
Nichol
Stuart T
ST
D000956:Antigens, Viral / Q000032:analysis; D001483:Base Sequence; D004196:Disease Outbreaks; D029043:Ebolavirus / Q000302:isolation & purification*; D004797:Enzyme-Linked Immunosorbent Assay; D019142:Hemorrhagic Fever, Ebola / Q000453:epidemiology / Q000821:virology*; D006801:Humans; D012367:RNA, Viral / Q000235:genetics; D014454:Uganda / Q000453:epidemiology
D000956:Antigens, Viral; D012367:RNA, Viral