title: Cardiac and peripheral blood similarities in the comparison of nordiazepam and bromazepam blood concentrations.
abstract: Concomitant heart and peripheral blood determinations were performed on 40 fatal cases involving nordiazepam (20 cases) and bromazepam (20 cases). The heart blood concentration for the two drugs (588 ng/mL for nordiazepam and 802 ng/mL for bromazepam) does not differ from the corresponding peripheral blood concentration (587 ng/mL for nordiazepam and 883 ng/mL for bromazepam). The mean ratios for the heart and peripheral blood concentrations were 0.95 for nordiazepam and 0.86 for bromazepam. No postmortem redistribution was observed for these two benzodiazepines. The authors thus suggest that corresponding heart blood can be proposed in the quantitative analysis of these drugs when peripheral blood is unavailable. The present study also shows the stability of the two drugs after a year of storage.
authors.affiliation: INPS, Laboratoire de Police Scientifique de Marseille, Section Toxicologie, 97, boulevard Camille Flammarion, BP30, 13245 Marseille, France. rop-pos.pok@interieur.gouv.fr
authors.forename: P-Rop
authors.initials: PR
authors.lastname: Pos Pok
authors.forename: Djamel
authors.initials: D
authors.lastname: Haddouche
authors.forename: Michel
authors.initials: M
authors.lastname: Mauras
authors.forename: Erika
authors.initials: E
authors.lastname: Kuhlmann
authors.forename: Joëlle
authors.initials: J
authors.lastname: Burle
authors.forename: Thierry
authors.initials: T
authors.lastname: Salmon
authors.forename: Emilie
authors.initials: E
authors.lastname: Berland
authors.forename: P-Emmanuel
authors.initials: PE
authors.lastname: Coiffait
authors.forename: Alain
authors.initials: A
authors.lastname: Viala
mesh_terms: D000328:Adult; D014151:Anti-Anxiety Agents / Q000032:analysis* / Q000097:blood* / Q000493:pharmacokinetics; D001711:Biotransformation; D001960:Bromazepam / Q000031:analogs & derivatives / Q000032:analysis* / Q000097:blood* / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008297:Male; D009206:Myocardium / Q000737:chemistry*; D003708:Nordazepam / Q000032:analysis* / Q000097:blood* / Q000493:pharmacokinetics; D010076:Oxazepam / Q000032:analysis / Q000097:blood; D013056:Spectrophotometry, Ultraviolet
chemical_list: D014151:Anti-Anxiety Agents; C042089:3-hydroxybromazepam; D003708:Nordazepam; D010076:Oxazepam; D001960:Bromazepam