Synthetic studies on kohamaic acids: synthesis of structurally simplified analogs of kohamaic acid A.
Kohamaic acid A is a potent DNA polymerase inhibitor isolated from the Okinawan marine sponge Ircinia sp. A series of structurally simplified analogs of kohamaic acid A were synthesized with the aim of evaluating structure-activity relationships.
Takikawa
Hirosato
H
Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, Japan.
Kamatani
Naoki
N
Nakanishi
Kohei
K
Tashiro
Takuya
T
Sasaki
Mitsuru
M
Yoshida
Hiromi
H
Mizushina
Yoshiyuki
Y
D000818:Animals; D002417:Cattle; D004256:DNA Polymerase I / Q000037:antagonists & inhibitors; D019951:DNA Polymerase beta / Q000037:antagonists & inhibitors; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology
D004791:Enzyme Inhibitors; D013729:Terpenes; C475030:kohamaic acid A; D004256:DNA Polymerase I; D019951:DNA Polymerase beta