Nutritional regulation of glucagon-like peptide-1 secretion.
Glucagon-like peptide-1 (GLP-1), released from L-cells in the intestinal epithelium, plays an important role in postprandial glucose homeostasis and appetite control. Following the recent therapeutic successes of antidiabetic drugs aimed at either mimicking GLP-1 or preventing its degradation, attention is now turning towards the L-cell, and addressing whether it would be both possible and beneficial to stimulate the endogenous release of GLP-1 in vivo. Understanding the mechanisms underlying GLP-1 release from L-cells is key to this type of approach, and the use of cell line models has led to the identification of a variety of pathways that may underlie the physiological responses of L-cells to food ingestion. This review focuses on our current understanding of the signalling mechanisms that underlie L-cell nutrient responsiveness.
Tolhurst
Gwen
G
Cambridge Institute for Medical Research and Department of Clinical Biochemistry, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK.
Reimann
Frank
F
Gribble
Fiona M
FM
D000818:Animals; D004435:Eating / Q000502:physiology; D019858:Enteroendocrine Cells / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism*; D005947:Glucose / Q000008:administration & dosage / Q000378:metabolism; D050491:Glutamate Plasma Membrane Transport Proteins / Q000378:metabolism; D006801:Humans; D054086:KATP Channels / Q000378:metabolism; D008954:Models, Biological; D015398:Signal Transduction; D013650:Taste Buds / Q000502:physiology
D050491:Glutamate Plasma Membrane Transport Proteins; D054086:KATP Channels; D052216:Glucagon-Like Peptide 1; D005947:Glucose