Antioxidant activity of butane type lignans, secoisolariciresinol, dihydroguaiaretic acid, and 7,7'-oxodihydroguaiaretic acid.
The antioxidant activity of butane-type lignans was evaluated. Secoisolariciresinol (SECO) and dihydroguaiaretic acid (DGA) showed higher radical scavenging activity than that of 7,7'-dioxodihydroguaiaretic acid (ODGA). SECO and DGA inhibited the oxidation of unsaturated fatty acid. Both enantiomers of DGA were also lipoxygenase inhibitors, but neither enantiomer of SECO inhibited the lipoxygenase activity.
Yamauchi
Satoshi
S
Faculty of Agriculture, Ehime University, Japan.
Masuda
Toshiya
T
Sugahara
Takuya
T
Kawaguchi
Yuya
Y
Ohuchi
Maya
M
Someya
Tatsushi
T
Akiyama
Jun
J
Tominaga
Shiori
S
Yamawaki
Manami
M
Kishida
Taro
T
Akiyama
Koichi
K
Maruyama
Masafumi
M
D002073:Butanes / Q000737:chemistry*; D002072:Butylene Glycols / Q000737:chemistry / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology*; D006139:Guaiacol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology*; D016859:Lipoxygenase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D010084:Oxidation-Reduction; D013237:Stereoisomerism
C534726:7,7'-oxodihydroguaiaretic acid; D002073:Butanes; D002072:Butylene Glycols; D016166:Free Radical Scavengers; D017705:Lignans; D016859:Lipoxygenase Inhibitors; C015816:dihydroguaiaretic acid; D006139:Guaiacol; C060283:secoisolariciresinol