title: Silent cardiac dysfunction and exercise intolerance in HIV+ men receiving combined antiretroviral therapies.
abstract: Resting and exercise cardiac function, skeletal muscle oxygenation and whole-body aerobic exercise capacities were evaluated prospectively in cardiac symptom-free HIV men receiving antiretroviral therapies and in healthy controls matched for age, physical activity, smoking and body surface area. HIV patients showed resting cardiac dysfunction, altered cardiac responses to exercise and depressed exercise tolerance. Exercise stroke volume kinetics and muscle oxygenation were impaired in HIV patients, especially in those with resting diastolic dysfunction.
authors.affiliation: EA 4278, Faculty of Sciences, Avignon, France. gilles.thoni@univ-montp1.fr
authors.forename: Gilles J
authors.initials: GJ
authors.lastname: Thöni
authors.forename: Iris
authors.initials: I
authors.lastname: Schuster
authors.forename: Guillaume
authors.initials: G
authors.lastname: Walther
authors.forename: Stéphane
authors.initials: S
authors.lastname: Nottin
authors.forename: Agnès
authors.initials: A
authors.lastname: Vinet
authors.forename: Franck
authors.initials: F
authors.lastname: Boccara
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Mauboussin
authors.forename: Isabelle
authors.initials: I
authors.lastname: Rouanet
authors.forename: Stéphane
authors.initials: S
authors.lastname: Edérhy
authors.forename: Michel
authors.initials: M
authors.lastname: Dauzat
authors.forename: Patick
authors.initials: P
authors.lastname: Messner-Pellenc
authors.forename: Philippe
authors.initials: P
authors.lastname: Obert
mesh_terms: D000328:Adult; D015308:Anaerobic Threshold / Q000502:physiology; D023241:Antiretroviral Therapy, Highly Active; D004562:Electrocardiography; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D017079:Exercise Tolerance / Q000502:physiology; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism; D011446:Prospective Studies; D013318:Stroke Volume / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology / Q000821:virology*