Gastroprotective mechanism of Vanillosmopsis arborea bark essential oil.
This study was aimed to clarify the mechanism of gastroprotection by Vanillosmopsis arborea Baker essential oil (EOVA) using ethanol-induced gastric mucosal damage in mice. Gastric lesions were significantly reduced by EOVA (200 and 400 mg/kg). Chemical analysis showed that the major compound of EOVA was alpha-bisabolol. Pretreatment of mice with yohimbine, the alpha2-antagonist, greatly suppressed the gastroprotective effect of OEVA. Furthermore, OEVA gastroprotection was not attenuated in mice pretreated with indomethacin, L-NAME or glibenclamide, the respective inhibitors of cyclooxygenase, nitric oxide synthase and K(+)(ATP) channel activation. These data suggest that OEVA affords gastroprotection most possibly by alpha2-receptor activation.
de O Leite
Gerlânia
G
Laboratório de Pesquisas em Produtos Naturais, Universidade Regional do Cariri, Crato, Brazil.
da Penha
Antonia Rosângela
AR
Fernandes
Cícera N
CN
Souza
Heloísa Helena F
HH
da Costa
José Galberto M
JG
Campos
Adriana R
AR
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D000897:Anti-Ulcer Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D019659:Asteraceae / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000494:pharmacology; D000431:Ethanol; D005753:Gastric Mucosa / Q000187:drug effects*; D005905:Glyburide / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D051379:Mice; D023421:Models, Animal; D000081222:Monocyclic Sesquiterpenes; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000032:analysis; D013276:Stomach Ulcer / Q000517:prevention & control; D015016:Yohimbine / Q000494:pharmacology
D000317:Adrenergic alpha-Antagonists; D000897:Anti-Ulcer Agents; D004791:Enzyme Inhibitors; D000081222:Monocyclic Sesquiterpenes; D009822:Oils, Volatile; D010936:Plant Extracts; D012717:Sesquiterpenes; C004497:bisabolol; D015016:Yohimbine; D000431:Ethanol; D005905:Glyburide; D019331:NG-Nitroarginine Methyl Ester; D007213:Indomethacin