title: Predictors of intracerebral hemorrhage severity and its outcome in Japanese stroke patients.
abstract: OBJECTIVE
  The aim of this investigation was to determine the factors influencing acute intracerebral hemorrhage severity on admission and clinical outcomes at discharge.
  
  
  METHODS
  Sixty acute stroke hospitals throughout Japan participated in the Japan Standard Stroke Registry Study (JSSRS), documenting the in-hospital course of 16,630 consecutive patients with acute stroke from January 2001 to March 2004. We identified 2,840 adult patients from the JSSRS who had intracerebral hemorrhage.
  
  
  RESULTS
  Intracerebral hemorrhage severity on admission was strongly related to age, previous stroke history, and hemorrhage size in a monotone fashion [chi(2)(9) = 374.5, p < 0.0001]. Drinking history was also predictive of intracerebral hemorrhage severity on admission, but the association was not monotone. Interestingly, intracerebral hemorrhage severity on admission was increased in nondrinking and heavy drinking compared to mild drinking (p < 0.05). Unsuccessful outcome (modified Rankin scale score = 3-6) was related to age, previous stroke history, hemorrhage size, and intracerebral hemorrhage severity on admission [chi(2)(9) = 830.4, p < 0.0001]. Mortality was related to hemorrhage size, intraventricular hemorrhage, intracerebral hemorrhage severity on admission, and surgical operation [chi(2)(7) = 540.4, p < 0.0001].
  
  
  CONCLUSIONS
  We could find four varied factors associated with intracerebral hemorrhage severity and its outcomes. Interestingly, intracerebral hemorrhage severity tended to be greater in nondrinking and heavy drinking than mild drinking. Additionally, surgical operation decreased intracerebral hemorrhage mortality.
authors.affiliation: Kagawa University School of Medicine, Kagawa, Japan. naohisa@med.kagawa-u.ac.jp
authors.forename: Naohisa
authors.initials: N
authors.lastname: Hosomi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Naya
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ohkita
authors.forename: Mao
authors.initials: M
authors.lastname: Mukai
authors.forename: Takehiro
authors.initials: T
authors.lastname: Nakamura
authors.forename: Masaki
authors.initials: M
authors.lastname: Ueno
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Dobashi
authors.forename: Koji
authors.initials: K
authors.lastname: Murao
authors.forename: Hisashi
authors.initials: H
authors.lastname: Masugata
authors.forename: Takanori
authors.initials: T
authors.lastname: Miki
authors.forename: Masakazu
authors.initials: M
authors.lastname: Kohno
authors.forename: Shotai
authors.initials: S
authors.lastname: Kobayashi
authors.forename: James A
authors.initials: JA
authors.lastname: Koziol
mesh_terms: D000367:Age Factors; D000368:Aged; D000428:Alcohol Drinking / Q000453:epidemiology; D002543:Cerebral Hemorrhage / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D016208:Databases, Factual; D050171:Dyslipidemias / Q000097:blood; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents