title: The relationship between cardiac autonomic neuropathy and Tei index in patients with type II diabetes mellitus.
abstract: OBJECTIVE
  We have investigated the relationship between silent cardiac autonomic neuropathy (CAN), one of the most important causes of mortality in diabetic patients, and the Tei index, which is an indicator of global ventricular function.
  
  
  METHODS
  Among the patients with type 2 diabetes mellitus, 15 without autonomic neuropathy (Ewing score < 1) were accepted as CAN (-) and 18 with autonomic neuropathy (Ewing score > or =1) were accepted as CAN (+).Twelve healthy individuals were included in the control group. Diastolic dysfunction and Tei index were evaluated by means of 2-D and Doppler echocardiographic examination.
  
  
  RESULTS
  Not only Doppler mitral, but also tricuspid inflow parameters showed a significant decrease in E/A ratio, an increase in A wave amplitude and deceleration time with CAN (+) patients. Left ventricular Tei index and Ewing score were found to be positively correlated (P < 0.001, r = 0.55). Likewise to the correlation in the left ventricle, a positive correlation was also detected between right ventricular Tei index and Ewing score (P = 0.004, r = 0.43).
  
  
  CONCLUSIONS
  We have shown that in patients with type II diabetes, CAN is related with left and right ventricular diastolic dysfunction.We also have determined that the Tei index is in correlation with CAN (Ewing score), which is a complication of diabetes.
authors.affiliation: Uludag University Faculty of Medicine, Department of Cardiology, 16059 Gorukle, Bursa, Turkey. aakaderli@uludag.edu.tr
authors.forename: Aysel
authors.initials: A
authors.lastname: Aydin Kaderli
authors.forename: Sümeyye
authors.initials: S
authors.lastname: Güllülü
authors.forename: Bülent
authors.initials: B
authors.lastname: Ozdemir
authors.forename: Tunay
authors.initials: T
authors.lastname: Sentürk
authors.forename: Ali
authors.initials: A
authors.lastname: Aydinlar
mesh_terms: D001341:Autonomic Nervous System / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001342:Autonomic Nervous System Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D003971:Diastole; D015150:Echocardiography, Doppler; D005260:Female; D006331:Heart Diseases / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology*; D006334:Heart Function Tests; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology; D018497:Ventricular Dysfunction, Right / Q000503:physiopathology