title: Ascomycones A-C, heptaketide metabolites from an unidentified ascomycete.
abstract: The ascomycones A-C (1-3), three novel heptaketide-derived secondary metabolites, have been isolated from cultures of an unknown ascomycete. While 1 and 2 are closely related pyranonaphthoquinones, 3 has a bicyclic dihydronaphthoquinone core. Compounds 2 and 3 exhibited significant activity against several phytopathogenic fungi.
authors.affiliation: Institut für Organische Chemie, Universität Hamburg, Martin-Luther-King-Platz 6, D-20146 Hamburg, Germany. opatz@chemie.uni-hamburg.de
authors.forename: Till
authors.initials: T
authors.lastname: Opatz
authors.forename: Heinz
authors.initials: H
authors.lastname: Kolshorn
authors.forename: Eckhard
authors.initials: E
authors.lastname: Thines
authors.forename: Heidrun
authors.initials: H
authors.lastname: Anke
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D017173:Caenorhabditis elegans / Q000187:drug effects; D004754:Enterobacter / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D005616:French Guiana; D006801:Humans; D031220:Lepidium sativum / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D024301:Plant Bark / Q000382:microbiology; D011514:Proteus vulgaris / Q000187:drug effects; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D032983:Setaria Plant / Q000187:drug effects; D014431:Tylenchoidea / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D009285:Naphthoquinones; D011714:Pyrans; C568011:ascomycone A; C568012:ascomycone B; C568013:ascomycone C