title: Advanced glycation end products in pregnancies complicated with diabetes mellitus or preeclampsia.
abstract: OBJECTIVE
  Preeclampsia (PE) and diabetes mellitus (DM) are associated with oxidative stress. DM is complicated with formation of advanced glycation end products (AGEs), which are associated with oxidative stress. We hypothesized that elevated serum AGE would be found in pregnancies complicated by PE or DM.
  
  
  METHODS
  Circulating AGEs, 8-isoprostane, vitamin E, and antioxidant capacity were analyzed from study patients.
  
  
  RESULTS
  Serum AGE was elevated both in patients with type 1 DM and gestational DM, but not in PE, compared with controls. 8-isoprostane was elevated in patients with type 1 DM and PE compared with controls.
  
  
  CONCLUSIONS
  AGEs and 8-isoprostane are not elevated in parallel in pregnancies complicated with PE or DM, suggesting biological heterogeneity.
authors.affiliation: Department of Obstetrics and Gynecology, Ulleval University Hospital, Oslo, Norway. niem@uus.no
authors.forename: Nina K
authors.initials: NK
authors.lastname: Harsem
authors.forename: Kristin
authors.initials: K
authors.lastname: Braekke
authors.forename: Tale
authors.initials: T
authors.lastname: Torjussen
authors.forename: Kristian
authors.initials: K
authors.lastname: Hanssen
authors.forename: Anne Cathrine
authors.initials: AC
authors.lastname: Staff
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000097:blood*; D015237:Dinoprost / Q000031:analogs & derivatives / Q000097:blood; D005260:Female; D005290:Ferric Compounds / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000097:blood*; D006801:Humans; D008239:Lysine / Q000031:analogs & derivatives* / Q000097:blood; D018384:Oxidative Stress; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood*; D014810:Vitamin E / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; D005290:Ferric Compounds; D017127:Glycation End Products, Advanced; D014810:Vitamin E; C075750:8-epi-prostaglandin F2alpha; C048496:N(6)-carboxymethyllysine; D015237:Dinoprost; D008239:Lysine