Lamotrigine as an augmentation agent in treatment-resistant obsessive-compulsive disorder: a case report.
Obsessive-compulsive disorder (OCD) is a relatively common, often chronic and disabling disorder with high rates of partial and/or absent response to standard, recommended treatments. We report a case of treatment-resistant OCD that was successfully treated with a pharmacological augmentation of lamotrigine plus clomipramine. The patient, a 59-year-old woman, was on a stable dose of clomipramine (225 mg/day) when she was started on lamotrigine (up to 150 mg/day). After 10 weeks of this treatment, her clinical condition remarkably improved, as indicated by a significant decrease of the Yale-Brown Obsessive-Compulsive Scale. This case suggests some preliminary evidence that the addition of glutamatergic agent lamotrigine may be useful in treatment-resistant OCD. However, further controlled studies are needed to support this finding.
Uzun
O
O
Department of Psychiatry, Gulhane School of Medicine, Ankara, Turkey. ozcan.uzun@yahoo.com
D000927:Anticonvulsants / Q000008:administration & dosage*; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage*; D002997:Clomipramine / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance / Q000187:drug effects; D004359:Drug Therapy, Combination; D018691:Excitatory Amino Acid Antagonists / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy*; D014227:Triazines / Q000008:administration & dosage*
D000927:Anticonvulsants; D000929:Antidepressive Agents, Tricyclic; D018691:Excitatory Amino Acid Antagonists; D014227:Triazines; D002997:Clomipramine; D000077213:Lamotrigine