Promiscuous interaction between gold-specific T cells and APCs in gold allergy.
Gold compounds clinically used as immunomodulators have high potential to evoke hypersensitivity reactions as an adverse effect. To explore the mechanism of gold allergy, we immunologically characterized T cells infiltrating skin rashes and generated 44 gold-specific T cell clones and lines from a rheumatoid arthritis patient who developed skin rashes and systemic symptoms after gold treatment. CD4(+) and CD8(+) cells predominantly infiltrating the skin rashes and some of the T cell clones and lines shared common Vbetas. These cells exhibited Th0-like, Th2-like, and Tc1-like cytokine profiles, and showed chemotactic activities for thymus and activation-regulated chemokine and IFN-gamma-inducible protein-10 corresponding to the cytokine profiles. T cell recognition of gold consisted of MHC-restricted and MHC-independent pathways. Blocking studies with anti-MHC Abs indicated that the groove of MHC in APCs, where Ags should ordinarily be settled, did not serve as a conjugating site of gold for these T cells in certain cases. These observations raise the possibility that gold-specific CD4(+) and CD8(+) T cells and APCs promiscuously interact under stimulation with gold, resulting in various clinical manifestations in gold allergy.
Hashizume
Hideo
H
Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan. hihashiz@hama-med.ac.jp
Seo
Naohiro
N
Ito
Taisuke
T
Takigawa
Masahiro
M
Yagi
Hiroaki
H
D000368:Aged; D000938:Antigen-Presenting Cells / Q000276:immunology* / Q000473:pathology; D018501:Antirheumatic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002450:Cell Communication / Q000187:drug effects / Q000276:immunology*; D054357:Chemokine CXCL10 / Q000276:immunology; D002633:Chemotaxis / Q000187:drug effects / Q000276:immunology; D004342:Drug Hypersensitivity / Q000276:immunology* / Q000473:pathology; D005260:Female; D006046:Gold; D006052:Gold Sodium Thiomalate / Q000008:administration & dosage / Q000009:adverse effects*; D006649:Histocompatibility Antigens / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000276:immunology* / Q000473:pathology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000473:pathology; D018418:Th2 Cells / Q000276:immunology* / Q000473:pathology; D013950:Thymus Gland / Q000276:immunology / Q000473:pathology
D018501:Antirheumatic Agents; C114753:CXCL10 protein, human; D054357:Chemokine CXCL10; D006649:Histocompatibility Antigens; D006052:Gold Sodium Thiomalate; D006046:Gold