mRNA expression of lysyl oxidase and matrix metalloproteinase-12 in mouse skin.
Elastic fibers in the dermis play an important role in skin elasticity. The desmosine crosslinking structure constructed of lysyl oxidase (LOX) in elastic fibers contributes to elasticity, while elastic fibers are primarily degraded by one of the matrix metalloproteinases (MMPs), MMP-12. We investigated the gender differences and diurnal variation of these enzymes. Gender-based differences in LOX mRNA expression were detected, and were significantly lower in females. In contrast, higher MMP-12 mRNA expression was observed in the light period, suggesting that elastic fibers might be degraded in the light rather than the dark period.
Mizobe
Yurika
Y
Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuaka-shi, Japan.
Oikawa
Daichi
D
Tsuyama
Shoichiro
S
Akimoto
Yoriko
Y
Hamasu
Kousuke
K
Onitsuka
Eiichiro
E
Sato
Mikako
M
Takahata
Yoshihisa
Y
Morimatsu
Fumiki
F
Furuse
Mitsuhiro
M
D000818:Animals; D002940:Circadian Rhythm / Q000235:genetics; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D008297:Male; D053508:Matrix Metalloproteinase 12 / Q000235:genetics*; D051379:Mice; D008249:Protein-Lysine 6-Oxidase / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012727:Sex Characteristics; D012867:Skin / Q000378:metabolism*
D012333:RNA, Messenger; D008249:Protein-Lysine 6-Oxidase; D053508:Matrix Metalloproteinase 12