New technologies for delineating and characterizing the lipid exome: prospects for understanding familial combined hyperlipidemia.
This review summarizes the progress made in cutting through the biological and genetic complexity of the Gordian knot that is familial combined hyperlipidemia. We particularly focus on how the application of new genomic technologies, especially massively parallel sequencing and high-throughput genotyping platforms, promise to accelerate the gene discovery process in this common, highly atherogenic disorder, with important diagnostic and therapeutic implications.
Horswell
Stuart D
SD
Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Rd., London, W12 0NN United Kingdom.
Ringham
Helen E
HE
Shoulders
Carol C
CC
D000818:Animals; D003198:Computer Simulation; D005091:Exons / Q000235:genetics*; D006801:Humans; D006950:Hyperlipidemia, Familial Combined / Q000175:diagnosis* / Q000235:genetics*; D008055:Lipids / Q000032:analysis* / Q000235:genetics*; D013677:Medical Laboratory Science / Q000379:methods*
D008055:Lipids