title: Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence.
abstract: Genomic studies of cannabis use disorders have been limited. The cannabinoid receptor 1 gene (CNR1) on chromosome 6q14-15 is an excellent candidate gene for cannabis dependence due to the important role of the G-protein coupled receptor encoded by this gene in the rewarding effects of Delta9-tetrahydrocannabinol. Previous studies have found equivocal evidence for an association between SNPs in CNR1 and a general vulnerability to substance use disorders. We investigate the association between 9 SNPs spanning CNR1 and cannabis dependence in 1,923 individuals. Two SNPs that were previously associated with cannabis dependence in other studies were also significant with this phenotype in our analyses [rs806368 (P = 0.05) and rs806380 (P = 0.009)]. Haplotype analyses revealed the association to be largely driven by the SNP rs806380. These results suggest a role for the cannabinoid receptor 1 gene in cannabis dependence.
authors.affiliation: Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA. arpana@wustl.edu
authors.forename: Arpana
authors.initials: A
authors.lastname: Agrawal
authors.forename: Leah
authors.initials: L
authors.lastname: Wetherill
authors.forename: Danielle M
authors.initials: DM
authors.lastname: Dick
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Xuei
authors.forename: Anthony
authors.initials: A
authors.lastname: Hinrichs
authors.forename: Victor
authors.initials: V
authors.lastname: Hesselbrock
authors.forename: John
authors.initials: J
authors.lastname: Kramer
authors.forename: John I
authors.initials: JI
authors.lastname: Nurnberger
authors.forename: Marc
authors.initials: M
authors.lastname: Schuckit
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Bierut
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Edenberg
authors.forename: Tatiana
authors.initials: T
authors.lastname: Foroud
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D002189:Marijuana Abuse / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D043884:Receptor, Cannabinoid, CB1 / Q000235:genetics*; D055815:Young Adult
chemical_list: D043884:Receptor, Cannabinoid, CB1