Synthesis and biological activities of thio-avarol derivatives.
Eleven new thio-avarol derivatives (3-13) were synthesized. Their antimicrobial, brine shrimp lethality, and free-radical scavenging activities and acetylcholinesterase inhibition, together with 12 already reported semisynthetic thio-avarol derivatives (14-25), were evaluated. Structure-activity relationships among these thio derivatives were determined.
Pejin
Boris
B
Istituto di Chimica Biomolecole CNR, via Campi Flegrei, 34, I-80078 Pozzuoli (Napoli), Italy.
Iodice
Carmine
C
Tommonaro
Giuseppina
G
De Rosa
Salvatore
S
D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001156:Artemia / Q000187:drug effects*; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D047088:Dysidea / Q000737:chemistry; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013457:Sulfur Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000890:Anti-Infective Agents; D002800:Cholinesterase Inhibitors; D016166:Free Radical Scavengers; D012717:Sesquiterpenes; D013457:Sulfur Compounds; C023663:avarol