Estimation of renal function -- what is appropriate in cancer patients?
OBJECTIVE
To compare the accuracy of renal assessment in patients with cancer using radioisotope glomerular filtration rate (GFR), urine collection for creatinine clearance, Cockroft-Gault, Modification of Diet in Renal Disease (MDRD) and Wright formulae.


METHODS
Measurements of isotope GFR from 367 patients were compared with estimates from the described methods (Cockroft-Gault, MDRD, Wright). An analysis including a further 252 patients with an isotope GFR < or = 50 ml/min was also carried out.


RESULTS
The Wright formula was the most accurate form of estimating renal function for the first study group. The formulae were similar in accuracy in the second study group.


CONCLUSIONS
The Wright formula is the most accurate form of estimation of renal function in comparison with the isotope GFR for cancer patients. When there is a large proportion of patients with a low isotope GFR (< or = 50 ml/min), the formulae have similar accuracy.
Barraclough
L H
LH
Department of Clinical Oncology, Christie Hospital, Manchester, UK. lisahelenbone@hotmail.com
Field
C
C
Wieringa
G
G
Swindell
R
R
Livsey
J E
JE
Davidson
S E
SE
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D002712:Chlorides / Q000652:urine; D017608:Chromium Compounds / Q000652:urine; D002860:Chromium Radioisotopes; D003404:Creatinine / Q000652:urine; D004032:Diet; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D007674:Kidney Diseases / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000652:urine; D007677:Kidney Function Tests / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications / Q000503:physiopathology* / Q000652:urine; D012372:ROC Curve; D012044:Regression Analysis; D055815:Young Adult
D002712:Chlorides; D017608:Chromium Compounds; D002860:Chromium Radioisotopes; D003404:Creatinine; C017133:chromous chloride