title: Synthesis of 3,6-bicyclolides: a novel class of macrolide antibiotics.
abstract: The synthesis of 3,6-bicyclolides from erythromycin A oxime is described. This novel class of bridged bicyclic macrolides demonstrates potent in vitro and in vivo activities against a broad spectrum of bacteria including resistant respiratory tract pathogens.
authors.affiliation: Enanta Pharmaceuticals, Inc., 500 Arsenal Street, Watertown, MA 02472, USA.
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Gai
authors.forename: Datong
authors.initials: D
authors.lastname: Tang
authors.forename: Guoyou
authors.initials: G
authors.lastname: Xu
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Chen
authors.forename: Alexander
authors.initials: A
authors.lastname: Polemeropoulos
authors.forename: Zhe
authors.initials: Z
authors.lastname: Wang
authors.forename: Yat Sun
authors.initials: YS
authors.lastname: Or
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D018360:Crystallography, X-Ray / Q000379:methods; D015195:Drug Design; D018432:Drug Resistance, Multiple; D006801:Humans; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry* / Q000145:classification*; D051379:Mice; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D008968:Molecular Conformation; D012137:Respiratory System / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides