title: Ecological study of the effectiveness of isolation precautions in the management of hospitalized patients colonized or infected with Acinetobacter baumannii.
abstract: OBJECTIVE
  To assess the impact of isolation precautions on the incidence of patients colonized or infected with Acinetobacter baumannii (case patients) in a university hospital during the period from 1999 to 2006.
  
  
  METHODS
  Ecological study.
  
  
  METHODS
  The Besançon University Hospital in France, a 1,200-bed acute care hospital with approximately 50,000 admissions per year.
  
  
  METHODS
  Using Poisson regression analysis, we evaluated a total of 350,000 patient-days to determine the annual incidence of case patients. This annual incidence was used as the outcome variable, and infection control practices, antibiotic use, and other aggregated data regarding patients' age, sex, McCabe score, and immune status were used as covariates.
  
  
  RESULTS
  The implementation of isolation precautions was independently and negatively associated with the incidence of patients colonized or infected with A. baumannii (relative risk, 0.50 [95% confidence interval, 0.40-0.64]; P<.001).
  
  
  CONCLUSIONS
  Our study suggests that the implementation of isolation precautions, in addition to standard precautions, effectively prevents the spread of A. baumannii in a hospital setting.
authors.affiliation: Service d'Hygiène Hospitalière et d'Epidémiologie Moléculaire, Centre Hospitalier Universitaire Jean Minjoz, Besançon, France.
authors.forename: Houssein
authors.initials: H
authors.lastname: Gbaguidi-Haore
authors.forename: Sophie
authors.initials: S
authors.lastname: Legast
authors.forename: Michelle
authors.initials: M
authors.lastname: Thouverez
authors.forename: Xavier
authors.initials: X
authors.lastname: Bertrand
authors.forename: Daniel
authors.initials: D
authors.lastname: Talon
mesh_terms: D000151:Acinetobacter Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000517:prevention & control*; D040981:Acinetobacter baumannii / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification / Q000502:physiology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D003428:Cross Infection / Q000517:prevention & control; D024881:Drug Resistance, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D005602:France / Q000453:epidemiology; D006760:Hospitalization; D006801:Humans; D015994:Incidence; D017053:Infection Control; D008297:Male; D008875:Middle Aged; D010356:Patient Isolation
chemical_list: D000900:Anti-Bacterial Agents