Polymorphism in CC-chemokine ligand 2 associated with tuberculosis in Zambia.
Polymorphism in various genes that may influence susceptibility to tuberculosis (TB) was examined in 46 TB patients and 119 healthy tuberculin-positive controls in Zambia. The odds of having TB was 2.8-fold higher in carriers of the -2518 AG single-nucleotide polymorphism in the promoter region of the CC-chemokine ligand 2 than in those carrying the homozygous genotype AA (95%CI 1.3-5.5).
Buijtels
P C A M
PC
Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Centre, University Medical Centre Rotterdam, Rotterdam, The Netherlands. P.Buijtels@umcutrecht.nl
van de Sande
W W J
WW
Parkinson
S
S
Petit
P L C
PL
van der Sande
M A B
MA
van Soolingen
D
D
Verbrugh
H A
HA
van Belkum
A
A
D000328:Adult; D018932:Chemokine CCL2 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D014376:Tuberculosis / Q000235:genetics*; D015024:Zambia
D018932:Chemokine CCL2