Comparison of cefoxitin and oxacillin disk diffusion methods for detection of mecA-mediated resistance in Staphylococcus aureus in a large-scale study.
The recommended breakpoints for the cefoxitin disk diffusion test for Staphylococcus aureus were recently modified. In this large-sample study, cefoxitin sensitivity and specificity compared to those of oxacillin were 97.3% and 100%, respectively. This study validated the new cefoxitin breakpoints for the detection of mecA-mediated resistance in S. aureus.
Broekema
Nicole M
NM
Wisconsin State Laboratory of Hygiene, Communicable Disease Division, 465 Henry Mall, Madison, WI 53706, USA.
Van
Tam T
TT
Monson
Timothy A
TA
Marshall
Steven A
SA
Warshauer
David M
DM
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002440:Cefoxitin / Q000494:pharmacology*; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010068:Oxacillin / Q000494:pharmacology*; D012680:Sensitivity and Specificity; D013203:Staphylococcal Infections / Q000382:microbiology
D000900:Anti-Bacterial Agents; D002440:Cefoxitin; D010068:Oxacillin