title: Antischistosomal activity of aminoalkanethiols, aminoalkanethiosulfuric acids and the corresponding disulfides.
abstract: This paper discusses the development of a series of sulfur-containing compounds that show an interesting in vivo activity against infection by Schistosoma mansoni. These substances include the aminoalkanethiols, aminoalkanethiosulfuric acids and aminoalkyl disulfides, among others. Although the aminoethanethiols and their disulfide derivatives have presented a relatively high toxicity for the host animal, the aminoalkanethiosulfuric acids have a low toxicity and a high specificity for the adult female S. mansoni worms. In vitro studies with schistosomula, lung-phase schistosomula and adult worms have demonstrated effects on the tegument and the metabolism on these different stages of S. mansoni worms. The encapsulation of these drugs in a nanoemulsion has resulted in an increase in the in vitro activity.
authors.affiliation: Departamento de Bioquímica-Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais e Instituto Medicina Legal, Belo Horizonte, MG, Brazil.
authors.forename: Marcus Luiz
authors.initials: ML
authors.lastname: de Oliveira Penido
authors.forename: Paulo Marcos
authors.initials: PM
authors.lastname: Zech Coelho
authors.forename: Rômulo Teixeira
authors.initials: RT
authors.lastname: de Mello
authors.forename: Dorila
authors.initials: D
authors.lastname: Piló-Veloso
authors.forename: Mônica Cristina
authors.initials: MC
authors.lastname: de Oliveira
authors.forename: John Robert
authors.initials: JR
authors.lastname: Kusel
authors.forename: David Lee
authors.initials: DL
authors.lastname: Nelson
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity*; D005260:Female; D006801:Humans; D051379:Mice; D012550:Schistosoma mansoni / Q000187:drug effects*; D012555:Schistosomiasis mansoni / Q000188:drug therapy*; D013457:Sulfur Compounds / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity*
chemical_list: D000981:Antiprotozoal Agents; D013457:Sulfur Compounds