Altering pyridinone N-substituents to optimise activity as potential prodrugs for Alzheimer's disease.
Selective design modifications of specifically substituted 3-hydroxy-4(1H)-pyridinones show possibly advantageous ring freedom while maintaining metal-binding ability and antioxidant capacity, moving toward an efficient potential treatment for Alzheimer's disease.
Scott
Lauren E
LE
Medicinal Inorganic Chemistry Group, Department of Chemistry, University of British Columbia, Vancouver, Canada V6T 1Z1.
Page
Brent D G
BD
Patrick
Brian O
BO
Orvig
Chris
C
D000544:Alzheimer Disease / Q000188:drug therapy*; D000975:Antioxidants / Q000138:chemical synthesis / Q000494:pharmacology; D018360:Crystallography, X-Ray; D015195:Drug Design; D009682:Magnetic Resonance Spectroscopy; D018697:Nootropic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D011355:Prodrugs / Q000138:chemical synthesis* / Q000494:pharmacology*; D011728:Pyridones / Q000737:chemistry*
D000975:Antioxidants; D018697:Nootropic Agents; D011355:Prodrugs; D011728:Pyridones