Ovarian stimulation for fertility preservation in patients with cancer.
OBJECTIVE
To evaluate controlled ovarian hyperstimulation (COH) in women with cancer compared with healthy women.


METHODS
A retrospective cohort study.


METHODS
Academic assisted reproductive technology (ART) program.


METHODS
Fifty women undergoing oocyte retrieval before cancer treatment and 50 age-matched controls.


METHODS
None.


METHODS
Number of oocytes and matured oocytes retrieved, number of fertilized oocytes, days of stimulation, dose of gonadotropins.


RESULTS
There were no significant differences in the number of oocytes retrieved (13 vs. 11.5), the number of matured oocytes retrieved (9.7 vs. 9.6), and the number of oocytes fertilized (7.4 vs. 6.8). However, the patients with cancer had a longer duration of stimulation (10.5 vs. 9.0 days) and higher total dose of gonadotropins (4,174 IU vs. 3,416 IU).


CONCLUSIONS
In our study, reasonable ovarian response was achieved by women with cancer with increased doses of gonadotropins and a longer duration of stimulation.
Quintero
Rudolpho B
RB
Department of Obstetrics & Gynecology, Division of Reproductive Endocrinology & Infertility, Stanford University, Stanford, California 94304, USA.
Helmer
Amy
A
Huang
Jian Qun
JQ
Westphal
Lynn M
LM
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects; D001943:Breast Neoplasms / Q000150:complications* / Q000188:drug therapy; D002452:Cell Count; D005260:Female; D005298:Fertility; D006801:Humans; D007247:Infertility, Female / Q000209:etiology* / Q000628:therapy*; D054315:Oocyte Retrieval / Q000379:methods*; D009865:Oocytes / Q000166:cytology; D010062:Ovulation Induction / Q000379:methods*; D027724:Reproductive Techniques, Assisted; D012189:Retrospective Studies
D000970:Antineoplastic Agents