title: Sequence analysis of the complete SLITRK1 gene in Austrian patients with Tourette's disorder.
abstract: Mutations in the gene SLITRK1 (Slit and Trk-like 1) have been reported in patients with Tourette's disorder (TD). We sequenced the entire SLITRK1 gene including the coding region the 5' and 3' untranslated region in 92 Austrian patients with TD. No nucleotide changes within the protein-coding region were identified. One patient was found to carry a variant within the 3' untranslated region (3383g>a), which was absent in 192 control individuals and which segregated in two additional family members with tic symptoms. In conclusion, our results provide no evidence for SLITRK1 playing a major role in TD.
authors.affiliation: Department of Neurology, Medical University of Vienna, Austria. alexander.zimprich@meduniwien.ac.at
authors.forename: Alexander
authors.initials: A
authors.lastname: Zimprich
authors.forename: Katharina
authors.initials: K
authors.lastname: Hatala
authors.forename: Franz
authors.initials: F
authors.lastname: Riederer
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Stogmann
authors.forename: Harald N
authors.initials: HN
authors.lastname: Aschauer
authors.forename: Mara
authors.initials: M
authors.lastname: Stamenkovic
mesh_terms: D001317:Austria; D016022:Case-Control Studies; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D020125:Mutation, Missense; D009419:Nerve Tissue Proteins / Q000235:genetics*; D017422:Sequence Analysis, DNA; D005879:Tourette Syndrome / Q000235:genetics*
chemical_list: D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C505093:SLITRK1 protein, human