title: The importance of Alzheimer disease assessment scale-cognitive part in predicting progress for amnestic mild cognitive impairment to Alzheimer disease.
abstract: The aim of this study was to verify the usefulness of Alzheimer Disease Assessment Scale-cognitive subscale (ADAS-Cog), in screening participants at risk of developing Alzheimer disease (AD) among populations with amnestic mild cognitive impairment(aMCI). 98 outpatients with aMCI were recruited. Participants were revaluated after 1 year: 44 (44.9%) were progressed to AD (progressors), while 54 (55.1%) did not convert (nonprogressors MCI). At baseline, cognitive performances were more impaired in progressors assessed by MMSE and by a neuropsychological battery. When tested with the ADAS-Cog subscale, the 2 groups of participants at baseline, progressors, and nonprogressors MCI, were significantly different regarding total score, memory, and nonmemory subitems. Considering a cutoff of 9.5 total score, adjusted for education, ADAS-Cog subscale showed a good performance (area under the curve = 0.67; sensitivity = 0.62%; specificity = 0.73%) in predicting conversion from aMCI to AD. Progressors aMCI were characterized at baseline by a greater cognitive impairment. ADAS-Cog subscale is a useful and brief cognitive assessment tool to screen aMCI participants converting to AD within 1 year.
authors.affiliation: Department of Neurology, Geriatric Research Group, University of Brescia, via Romanino 1, Brescia, Italy. lrozzini@iol.it
authors.forename: Luca
authors.initials: L
authors.lastname: Rozzini
authors.forename: Barbara
authors.initials: B
authors.lastname: Vicini Chilovi
authors.forename: Erik
authors.initials: E
authors.lastname: Bertoletti
authors.forename: Marta
authors.initials: M
authors.lastname: Conti
authors.forename: Ilenia
authors.initials: I
authors.lastname: Delrio
authors.forename: Marco
authors.initials: M
authors.lastname: Trabucchi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Padovani
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000523:psychology*; D003072:Cognition Disorders / Q000175:diagnosis* / Q000523:psychology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis* / Q000523:psychology*; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D014057:Tomography, X-Ray Computed