title: Antioxidant activity of butane type lignans, secoisolariciresinol, dihydroguaiaretic acid, and 7,7'-oxodihydroguaiaretic acid.
abstract: The antioxidant activity of butane-type lignans was evaluated. Secoisolariciresinol (SECO) and dihydroguaiaretic acid (DGA) showed higher radical scavenging activity than that of 7,7'-dioxodihydroguaiaretic acid (ODGA). SECO and DGA inhibited the oxidation of unsaturated fatty acid. Both enantiomers of DGA were also lipoxygenase inhibitors, but neither enantiomer of SECO inhibited the lipoxygenase activity.
authors.affiliation: Faculty of Agriculture, Ehime University, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamauchi
authors.forename: Toshiya
authors.initials: T
authors.lastname: Masuda
authors.forename: Takuya
authors.initials: T
authors.lastname: Sugahara
authors.forename: Yuya
authors.initials: Y
authors.lastname: Kawaguchi
authors.forename: Maya
authors.initials: M
authors.lastname: Ohuchi
authors.forename: Tatsushi
authors.initials: T
authors.lastname: Someya
authors.forename: Jun
authors.initials: J
authors.lastname: Akiyama
authors.forename: Shiori
authors.initials: S
authors.lastname: Tominaga
authors.forename: Manami
authors.initials: M
authors.lastname: Yamawaki
authors.forename: Taro
authors.initials: T
authors.lastname: Kishida
authors.forename: Koichi
authors.initials: K
authors.lastname: Akiyama
authors.forename: Masafumi
authors.initials: M
authors.lastname: Maruyama
mesh_terms: D002073:Butanes / Q000737:chemistry*; D002072:Butylene Glycols / Q000737:chemistry / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology*; D006139:Guaiacol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology*; D016859:Lipoxygenase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: C534726:7,7'-oxodihydroguaiaretic acid; D002073:Butanes; D002072:Butylene Glycols; D016166:Free Radical Scavengers; D017705:Lignans; D016859:Lipoxygenase Inhibitors; C015816:dihydroguaiaretic acid; D006139:Guaiacol; C060283:secoisolariciresinol