Microwave accelerated aza-Claisen rearrangement.
A study of microwave-induced and standard thermal Overman rearrangement of selected allylic trichloroacetimidates 1a-1f, 6-8 to the corresponding acetamides 2a-2f, 9-11 is reported. The microwave-assisted rearrangement of trifluoroacetimidate 13 is also described. Using this methodology, an efficient access to versatile allylic trihaloacetamides building synthons was established.
Gajdosíková
Eva
E
Institute of Chemical Sciences, Department of Organic Chemistry, PJ Safárik University, Kosice, Slovak Republic. eva.gajdosikova@gmail.com
Martinková
Miroslava
M
Gonda
Jozef
J
Conka
Patrik
P
D000081:Acetamides / Q000138:chemical synthesis* / Q000737:chemistry; D001372:Aza Compounds / Q000737:chemistry*; D007096:Imidoesters / Q000737:chemistry*; D007536:Isomerism; D008872:Microwaves; D015394:Molecular Structure; D013696:Temperature
D000081:Acetamides; D001372:Aza Compounds; D007096:Imidoesters