Inflammatory response of coronary artery disease postmenopausal women is associated with the IVS1-397T > C estrogen receptor alpha polymorphism.
We analyzed the relationship between the IVS1-397T > C polymorphism of estrogen receptor alpha gene and inflammatory response of eighty postmenopausal women with an established coronary artery disease (CAD). We found that the IVS1-397T allele carriers exhibited an enhanced inflammatory response in vivo and in vitro. These patients had a higher number of total monocytes and their CD14(+)CD16(+) inflammatory subset in relation to CC homozygotes. The CT and TT women's LPS-stimulated whole blood cell cultures produced more IL6 and TNFalpha than did the cultures of CC women. Moreover, significantly more of the T allele patients had major post-coronary artery bypass grafting complications and less of them experienced subjective angina pectoris improvement. Summarizing, the IVS1-397T > C polymorphism allows us to identify a group of postmenopausal women with the strong inflammatory response which is associated with a higher incidence of the major post-CABG adverse cardiovascular complications.
Myśliwska
Jolanta
J
Department of Immunology, Medical University of Gdańsk, Ul. Debinki 1, 80-210 Gdańsk, Poland. jolmys@amg.gda.pl
Rutkowska
Aleksandra
A
Hak
Lukasz
L
Siebert
Janusz
J
Szyndler
Krzysztof
K
Rachoń
Dominik
D
D000368:Aged; D002478:Cells, Cultured; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000235:genetics* / Q000276:immunology*; D047628:Estrogen Receptor alpha / Q000235:genetics* / Q000276:immunology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism; D007958:Leukocyte Count; D018950:Lipopolysaccharide Receptors / Q000378:metabolism; D008213:Lymphocyte Activation; D008875:Middle Aged; D009000:Monocytes / Q000166:cytology / Q000276:immunology; D011110:Polymorphism, Genetic / Q000276:immunology*; D017698:Postmenopause; D017452:Receptors, IgG / Q000378:metabolism; D012015:Reference Standards; D013601:T-Lymphocytes / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D047628:Estrogen Receptor alpha; D015850:Interleukin-6; D018950:Lipopolysaccharide Receptors; D017452:Receptors, IgG; D014409:Tumor Necrosis Factor-alpha