Effects of fluoxetine on the reproduction of two prosobranch mollusks: Potamopyrgus antipodarum and Valvata piscinalis.
Fluoxetine is a widely used antidepressant, frequently found in aquatic ecosystems. We investigated its effects on two freshwater prosobranch gastropods: Valvata piscinalis (European valve snail) and Potamopyrgus antipodarum (New Zealand mudsnail), which have different reproductive modes. The fecundity of V. piscinalis (cumulate number of eggs at day 42) was not affected with an NOEC of 100 mvg/L nominal concentration (69 microg/L measured concentration). The mudsnail P. antipodarum responded in a biphasic dose-effect curve at low concentrations. The cumulate number of neonates at day 42 had an LOEC of 100 microg/L (69 microg/L) and an NOEC of 33.3 microg/L (13 microg/L), whereas the embryos in the brood pouch at day 42 only showed an LOEC of 3.7 microg/L (1 microg/L). We also observed histological effects in P. antipodarum (gonadal thickness). Among the sexual steroids we measured only testosterone which varied, independent of reproduction. Moreover the use of two closely related species highlights the interspecific variability.
Gust
M
M
Laboratoire d'écotoxicologie, Cemagref, 3b quai Chauveau, CP 220, 69336 Lyon Cedex 09, France. marion.gust@cemagref.fr
Buronfosse
T
T
Giamberini
L
L
Ramil
M
M
Mons
R
R
Garric
J
J
D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000032:analysis / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005298:Fertility / Q000187:drug effects; D005473:Fluoxetine / Q000032:analysis / Q000494:pharmacology*; D005618:Fresh Water / Q000737:chemistry; D049851:Gastropoda / Q000033:anatomy & histology / Q000187:drug effects* / Q000502:physiology; D006066:Gonads / Q000033:anatomy & histology / Q000187:drug effects; D011374:Progesterone / Q000378:metabolism; D012098:Reproduction / Q000187:drug effects; D013739:Testosterone / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000494:pharmacology*
D018687:Antidepressive Agents, Second-Generation; D014874:Water Pollutants, Chemical; D005473:Fluoxetine; D013739:Testosterone; D011374:Progesterone