title: Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
abstract: C4-Fluorinated analogues of solamin, an antitumor acetogenin, were synthesized and investigated for their antitumor activities against 39 tumor cell lines. C4-Fluorinated solamins showed more potent growth inhibitory activity against cancer cell lines than solamin.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Kojima
authors.forename: Hiromi
authors.initials: H
authors.lastname: Hayashi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Suzuki
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Tominaga
authors.forename: Naoyoshi
authors.initials: N
authors.lastname: Maezaki
authors.forename: Tetsuaki
authors.initials: T
authors.lastname: Tanaka
authors.forename: Takao
authors.initials: T
authors.lastname: Yamori
mesh_terms: D054378:Acetogenins / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001558:Benzethonium / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D054378:Acetogenins; D000970:Antineoplastic Agents; D001558:Benzethonium