11C-Acetate PET imaging for renal cell carcinoma.
OBJECTIVE
In this study, we investigated the effectiveness of positron emission tomography (PET) with (11)C-acetate (AC) for evaluation of renal cell carcinoma.


METHODS
Enrolled in the study were 20 patients with suspected renal tumour, one of whom had three renal lesions. In all, 22 renal lesions were evaluated. Following administration of 350 MBq (10 mCi) of AC, whole-body PET images were obtained. Based on these PET findings, kidney lesions were scored as positive or negative. The PET results were correlated with the CT findings and histological diagnosis after surgery.


RESULTS
In 18 patients, 20 tumours were diagnosed as renal cell carcinoma. Lesions in the remaining two patients were diagnosed as complicated cyst without malignant tissue. Of the 20 renal cell carcinomas. 14 (70%) showed positive AC PET findings; 6 were negative. The two patients with complicated cyst had negative AC PET findings. Of the 20 renal cell carcinomas, 19 were clear-cell carcinoma and 1 was a papillary cell carcinoma. This papillary cell carcinoma showed high AC uptake.


CONCLUSIONS
AC demonstrates marked uptake in renal cell carcinoma. These preliminary data show that AC is a possible PET tracer for detection of renal cancer.
Oyama
Nobuyuki
N
Department of Urology, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji, Fukui 910-1193, Japan. urono@u-fukui.ac.jp
Okazawa
Hidehiko
H
Kusukawa
Naoya
N
Kaneda
Taisei
T
Miwa
Yoshiji
Y
Akino
Hironobu
H
Fujibayashi
Yasuhisa
Y
Yonekura
Yoshiharu
Y
Welch
Michael J
MJ
Yokoyama
Osamu
O
D019342:Acetic Acid; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002250:Carbon Radioisotopes; D002292:Carcinoma, Renal Cell / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals
D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D019342:Acetic Acid