title: Discerning the degenerate transitions of scalar coupled 1H NMR spectra: correlation and resolved techniques at higher quantum.
abstract: The blend of spin topological filtering and the spin state selective detection of single quantum transitions by the two dimensional multiple quantum-single quantum correlation and higher quantum resolved techniques have been employed for simplifying the complexity of scalar coupled (1)H NMR spectra. The conventional two dimensional COSY and TOCSY experiments, though identify the coupled spin networks, fail to differentiate them due to severe overlap of transitions. Non-selective excitation of homonuclear higher quantum of protons results in filtering of spin systems irrespective of their spin topologies. The spin state selection by passive (19)F spins provides fewer transitions in each cross section of the single quantum dimension simplifying the analyses of the complex spectra. The degenerate single quantum transitions are further discerned by spin selective double and/or triple quantum resolved experiments that mimic simultaneous heteronuclear and selective homonuclear decoupling in the higher quantum dimension. The techniques aided the determination of precise values of spectral parameters and relative signs of the couplings.
authors.affiliation: NMR Research Centre, Indian Institute of Science, SIF, Bangalore, Karnataka 560 012, India.
authors.forename: G N
authors.initials: GN
authors.lastname: Manjunatha Reddy
authors.forename: T N
authors.initials: TN
authors.lastname: Guru Row
authors.forename: N
authors.initials: N
authors.lastname: Suryaprakash
mesh_terms: D001549:Benzamides / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods; D005466:Fluorocarbons / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D011789:Quantum Theory; D012680:Sensitivity and Specificity; D013057:Spectrum Analysis / Q000379:methods
chemical_list: D001549:Benzamides; D005466:Fluorocarbons; D006859:Hydrogen