Complement Receptor 1: disease associations and therapeutic implications.
Exaggerated complement activation is a key event in the pathogenesis of a range of autoimmune and inflammatory diseases. Complement Receptor 1 (CR1) has emerged as a molecule of immense interest in gaining insight to the susceptibility, pathophysiology, diagnosis, prognosis and therapy of such diseases. This review brings forth a composite view of the current understanding on the structure, functions, genetics, disease associations and therapeutic implications of CR1.
Khera
Rohan
R
Department of Biochemistry, All India Institute of Medical Sciences, New Delhi 110029, India.
Das
Nibhriti
N
D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000276:immunology / Q000628:therapy; D017463:Receptors, Complement 3b / Q000235:genetics / Q000276:immunology*
C509991:CR1 protein, human; D017463:Receptors, Complement 3b