Centrosome function during stem cell division: the devil is in the details.
Cell polarity is inherent to animal development and requires microtubules. In essentially all non-terminally differentiated somatic and male germ-line animal cells, microtubule organisation is governed by centrosomes. Animal development without centrosomes would therefore seem inconceivable. The claim of flies without centrosomes may appear to challenge this notion. Does it?
Gonzalez
Cayetano
C
Cell Division Group, Institute for Research in Biomedicine (IRB-Barcelona), PCB, c/ Josep Samitier 1-5, Barcelona, Spain. gonzalez@irbbarcelona.org
D000818:Animals; D002455:Cell Division / Q000502:physiology*; D016764:Cell Polarity; D018385:Centrosome / Q000502:physiology*; D004330:Drosophila / Q000254:growth & development / Q000502:physiology; D005260:Female; D005854:Germ Cells / Q000166:cytology / Q000378:metabolism; D006801:Humans; D008297:Male; D008870:Microtubules / Q000378:metabolism; D008954:Models, Biological; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism