title: Botulinum toxin A injection for primary and recurrent chalazia.
abstract: BACKGROUND
  To study the efficacy and safety of subcutaneous botulinum toxin A injections in the treatment of primary and recurrent chalazia.
  
  
  METHODS
  Prospective, placebo-controlled consecutive case-series trial. Sixty three patients were divided into two groups: group 1 consisting of 32 patients previously diagnosed with and treated for primary or recurrent chalazia with 2-5 international units (IU) in 0.2-0.5 ml of preserved saline solution of botulinum toxin injection, and group 2 consisting of 31 patients receiving placebo. The main outcome measures were localization and duration of the disease, size of chalazion before and after treatment, clinical resolution of chalazion, time to resolution, and complications of treatment.
  
  
  RESULTS
  There was a clinically and statistically significant between-group difference in the rate of therapeutic success and post-therapeutic chalazion regression, but not in the rate of complications.
  
  
  CONCLUSIONS
  Botulinum toxin A injection is effective and safe treatment for primary and recurrent chalazia. Lesion regression that did not respond to the average of two injections would benefit more from surgical excision or systemic antibiotic therapy.
authors.affiliation: University Department of Ophthalmology, University Hospital Sestre milordnice, Zagreb, Croatia.
authors.forename: Tamara
authors.initials: T
authors.lastname: Knezevic
authors.forename: Renata
authors.initials: R
authors.lastname: Ivekovic
authors.forename: Jasna Pavicic
authors.initials: JP
authors.lastname: Astalos
authors.forename: Katia
authors.initials: K
authors.lastname: Novak Laus
authors.forename: Zdravko
authors.initials: Z
authors.lastname: Mandic
authors.forename: Aljosa
authors.initials: A
authors.lastname: Matejcic
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage* / Q000009:adverse effects; D017043:Chalazion / Q000188:drug therapy*; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000008:administration & dosage* / Q000009:adverse effects; D011446:Prospective Studies; D012008:Recurrence; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A