Correlating phenotype and genotype in autism spectrum disorder research.
Genotype-phenotype association studies often require investigators to collaborate across institutions and research disciplines. However, the relevant data are often inaccessible, heterogeneous, and difficult to correlate. Our query aggregator allows an investigator to compose a query, broadcast it to Autism Consortium databases and aggregate the query results in near-real-time. This collaborative infrastructure enables integrative investigations across disciplines, institutions and modalities, and may drive new hypotheses for the genetic basis of disease.
McMurry
Andrew
A
Center for Biomedical Informatics, Harvard Medical School, Boston, MA and Autism Consortium, Boston, MA, USA.
Cervone
Maria
M
Polumbo
Gregory
G
McCray
Alexa T
AT
D001321:Autistic Disorder / Q000453:epidemiology / Q000235:genetics*; D003628:Database Management Systems; D016208:Databases, Factual; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016247:Information Storage and Retrieval / Q000379:methods*; D012107:Research Design; D013223:Statistics as Topic; D014481:United States; D014584:User-Computer Interface