Glutamate cysteine ligase modifier (GCLM) subunit gene is not associated with methamphetamine-use disorder or schizophrenia in the Japanese population.
A recent study showed a significant association between schizophrenia in European samples and the glutamate cysteine ligase modifier (GCLM) subunit gene, which is the key glutathione (GSH)-synthesizing enzyme. Since the symptoms of methamphetamine (METH)-induced psychosis are similar to those of schizophrenia, the GCLM gene is thought to be a good candidate gene for METH-use disorder or related disorders. To evaluate the association between the GCLM gene and METH-use disorder and schizophrenia, we conducted a case-control study of Japanese subjects (METH-use disorder, 185 cases; schizophrenia, 742 cases; and controls, 819). Four SNPs (2 SNPs from an original report and JSNP database, and 2 "tagging SNPs" from HapMap database) in the GCLM gene were examined in this association analysis; one SNP showed an association with both METH-use disorder and METH-induced psychosis. After Bonferroni's correction for multiple testing, however, this significance disappeared. No significant association was found with schizophrenia. Our findings suggest that a common genetic variation in the GCLM gene might not contribute to the risk of METH-use disorder and schizophrenia in the Japanese population.
Kishi
Taro
T
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan. taroh@fujita-hu.ac.jp
Ikeda
Masashi
M
Kitajima
Tsuyoshi
T
Yamanouchi
Yoshio
Y
Kinoshita
Yoko
Y
Kawashima
Kunihiro
K
Inada
Toshiya
T
Harano
Mutsuo
M
Komiyama
Tokutaro
T
Hori
Toru
T
Yamada
Mitsuhiko
M
Iyo
Masaomi
M
Sora
Ichiro
I
Sekine
Yoshimoto
Y
Ozaki
Norio
N
Ujike
Hiroshi
H
Iwata
Nakao
N
D000328:Adult; D019969:Amphetamine-Related Disorders / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D005260:Female; D005838:Genotype; D005721:Glutamate-Cysteine Ligase / Q000737:chemistry / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D021122:Protein Subunits / Q000235:genetics*; D011605:Psychoses, Substance-Induced / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
D021122:Protein Subunits; D008694:Methamphetamine; D005721:Glutamate-Cysteine Ligase