The re-emergence of pertussis: implications for diagnosis and surveillance.
Pertussis, or whooping cough, a highly contagious disease caused by Bordetella pertussis, is making a comeback globally and nationally in spite of reasonable vaccination coverage. This paper provides an update on laboratory testing methods that assist the confirmation of clinical disease and investigation of outbreaks. Laboratory confirmation of the diagnosis by polymerase chain reaction or serology should be attempted, especially when atypical pertussis is suspected clinically. Genetic and antigenic variations in virulence factors of strains circulating in the population should also be monitored.
Sintchenko
Vitali
V
Centre for Infectious Diseases and Microbiology-Public Health, Sydney West Area Health Service, Western Clinical School, University of Sydney. vitali.sintchenko@swahs.health.nsw.gov.au
D000293:Adolescent; D001886:Bordetella pertussis / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009517:New South Wales / Q000453:epidemiology; D010567:Pertussis Vaccine; D010865:Pilot Projects; D011159:Population Surveillance; D012307:Risk Factors; D014611:Vaccination; D014917:Whooping Cough / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics / Q000517:prevention & control
D010567:Pertussis Vaccine