Endometrial atypical hyperplasia and subsequent diagnosis of endometrial cancer: a retrospective audit and literature review.
This study investigates the rate of endometrial carcinoma found at hysterectomy in women with a biopsy diagnosis of atypical endometrial hyperplasia, in the John Radcliffe Hospital, Oxford. The Gynecologic Oncology Group (GOG) recently reported a rate of 42.6% in a large prospective study in the USA (Trimble et al. 2006). This retrospective study has identified a similar rate of 45.9% at the John Radcliffe. There is much interest in conservative therapies for atypical endometrial hyperplasia, but with such a high incidence of endometrial carcinoma in cases of atypical endometrial hyperplasia diagnosed by endometrial biopsy, it would seem prudent to exercise caution when considering any conservative therapy.
Pennant
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Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Headley Way, Headington, Oxford, UK.
Manek
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Kehoe
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D000230:Adenocarcinoma / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D004717:Endometrium / Q000473:pathology*; D005260:Female; D006801:Humans; D006965:Hyperplasia; D015994:Incidence