Myxomatous neoplasms in the perineal region of baboons.
BACKGROUND
In baboons, Papio sp. neoplasms tend to affect the hematopoietic system most commonly, with rare documentation of myxomatous neoplasms. In contrast, women can develop myxomatous masses within deep peripelvic tissues with some frequency during their reproductive years.


METHODS
We have identified and examined, retrospectively, myxomatous perineal masses in twelve female baboons within one research facility and compared their histopathologic, immunohistochemical and electron microscopic features to their human variants.


RESULTS
Our results indicate that these myxomatous neoplasms, in humans and non-human primates, share common features.


CONCLUSIONS
Further research, particularly molecular genetic analysis, may be needed to identify the baboon as a true animal model for myxomatous perineal neoplasms.
Wallace
Shannon M
SM
Department of Pathology, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA. shannon.m.wallace@us.army.mil
Szabo
Kathleen A
KA
Schlabritz-Loutsevitch
Natalia E
NE
Dick
Edward J
EJ
Blanchard
Terrell W
TW
Hubbard
Gene B
GB
D000818:Animals; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D008854:Microscopy, Electron / Q000662:veterinary; D008992:Monkey Diseases / Q000473:pathology*; D009232:Myxoma / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary*; D010215:Papio; D010386:Pelvic Neoplasms / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary*; D010502:Perineum / Q000473:pathology*; D012189:Retrospective Studies