EphrinA I-targeted nanoshells for photothermal ablation of prostate cancer cells.
Gold-coated silica nanoshells are a class of nanoparticles that can be designed to possess strong absorption of light in the near infrared (NIR) wavelength region. When injected intravenously, these nanoshells have been shown to accumulate in tumors and subsequently mediate photothermal treatment, leading to tumor regression. In this work, we sought to improve their specificity by targeting them to prostate tumor cells. We report selective targeting of PC-3 cells with nanoshells conjugated to ephrinA I, a ligand for EphA2 receptor that is overexpressed on PC-3 cells. We demonstrate selective photo-thermal destruction of these cells upon application of the NIR laser.
Gobin
Andre M
AM
Department of Bioengineering, Rice University, Houston, TX 77251-1892, USA.
Moon
James J
JJ
West
Jennifer L
JL
D045744:Cell Line, Tumor; D002470:Cell Survival / Q000528:radiation effects; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007259:Infrared Rays / Q000627:therapeutic use; D008297:Male; D049329:Nanostructures / Q000627:therapeutic use*; D010789:Phototherapy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000503:physiopathology*; D036081:Receptors, Eph Family
D036081:Receptors, Eph Family