Autoinducer-2 production in Campylobacter jejuni contributes to chicken colonization.
Inactivation of luxS, encoding an AI-2 biosynthesis enzyme, in Campylobacter jejuni strain 81-176 significantly reduced colonization of the chick lower gastrointestinal tract, chemotaxis toward organic acids, and in vitro adherence to LMH chicken hepatoma cells. Thus, AI-2 production in C. jejuni contributes to host colonization and interactions with epithelial cells.
Quiñones
Beatriz
B
U.S. Department of Agriculture, Agricultural Research Service, Western Regional Research Center, Produce Safety and Microbiology Research Unit, 800 Buchanan Street, Albany, CA 94710, USA. Beatriz.Quinones@ars.usda.gov
Miller
William G
WG
Bates
Anna H
AH
Mandrell
Robert E
RE
D000818:Animals; D000831:Animals, Newborn; D001422:Bacterial Adhesion; D001426:Bacterial Proteins / Q000235:genetics; D002169:Campylobacter Infections / Q000382:microbiology*; D016123:Campylobacter jejuni / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology; D013437:Carbon-Sulfur Lyases / Q000235:genetics; D002633:Chemotaxis; D002645:Chickens; D017353:Gene Deletion; D022781:Hepatocytes / Q000382:microbiology; D006714:Homoserine / Q000031:analogs & derivatives* / Q000378:metabolism; D007421:Intestine, Small / Q000382:microbiology*; D007783:Lactones / Q000378:metabolism*; D037521:Virulence Factors / Q000378:metabolism*
D001426:Bacterial Proteins; D007783:Lactones; C091088:N-octanoylhomoserine lactone; D037521:Virulence Factors; D006714:Homoserine; D013437:Carbon-Sulfur Lyases; C117753:LuxS protein, Bacteria