In vivo (19)F MRI and (19)F MRS of (19)F-labelled boronophenylalanine-fructose complex on a C6 rat glioma model to optimize boron neutron capture therapy (BNCT).
Boron neutron capture therapy (BNCT) is a promising binary modality used to treat malignant brain gliomas. To optimize BNCT effectiveness a non-invasive method is needed to monitor the spatial distribution of BNCT carriers in order to estimate the optimal timing for neutron irradiation. In this study, in vivo spatial distribution mapping and pharmacokinetics evaluation of the (19)F-labelled boronophenylalanine (BPA) were performed using (19)F magnetic resonance imaging ((19)F MRI) and (19)F magnetic resonance spectroscopy ((19)F MRS). Characteristic uptake of (19)F-BPA in C6 glioma showed a maximum at 2.5 h after compound infusion as confirmed by both (19)F images and (19)F spectra acquired on blood samples collected at different times after infusion. This study shows the ability of (19)F MRI to selectively map the bio-distribution of (19)F-BPA in a C6 rat glioma model, as well as providing a useful method to perform pharmacokinetics of BNCT carriers.
Porcari
Paola
P
CNR-INFM SOFT, Physics Department, University of Rome "Sapienza", Rome, Italy. paola.porcari@roma1.infn.it
Capuani
Silvia
S
D'Amore
Emanuela
E
Lecce
Mario
M
La Bella
Angela
A
Fasano
Fabrizio
F
Campanella
Renzo
R
Migneco
Luisa Maria
LM
Pastore
Francesco Saverio
FS
Maraviglia
Bruno
B
D000818:Animals; D001896:Boron Compounds / Q000493:pharmacokinetics; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D001921:Brain / Q000378:metabolism / Q000473:pathology; D001932:Brain Neoplasms / Q000378:metabolism / Q000532:radiotherapy; D045744:Cell Line, Tumor; D003710:Demography; D005462:Fluorine Radioisotopes / Q000097:blood; D005632:Fructose / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D005910:Glioma / Q000378:metabolism / Q000532:radiotherapy*; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009374:Neoplasms, Experimental / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar
C089739:4-boronophenylalanine-fructose; D001896:Boron Compounds; D005462:Fluorine Radioisotopes; D005632:Fructose