[Treatment of brain injured rats through transplanting amniotic-derived mesenchymal stem cells in different ways].
OBJECTIVE
To compare the behavioral improvement to find the best transplantation approach for treating brain injury through transplanting amniotic-derived mesenchymal stem cells into brain injured rats in different ways.


METHODS
Eighty brain injured Wista rats were randomly divided into a control group with brain injury alone (n=20) and a treatment group(n=60) which were further evenly divided into Group A (transplanted through the vena caudalis), Group B (transplanted through the ventriculus cerebri lateralis), and Group C (transplanted through the injured brain area). Each group was transplanted with amniotic-derived esenchymal stem cells, and their therapeutic efficacy would be evaluated through the neurological severity score (NSS).


RESULTS
Compared with other groups, the behaviors of Group C had markedly improved. There was statistically significant difference in the 2 groups (P<0.05). Compared with the control group, the behaviors of Group A and Group B had marked improvement. There was statistically significant difference in the 3 groups (P<0.05). However, there was no significant difference between Group A and the control group (P>0.05).


CONCLUSIONS
Transplanting the amniotic-derived mesenchymal stem cells into the injured brain area may be effective for brain injury in rats.
Wang
Gong-ping
GP
Department of Neurosurgery, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052û Department of Tumor, First Affiliated Hospital, Henan University of Science and Technology, Luoyang Henan 471003, China.
Yang
Bo
B
Guan
Fang-xia
FX
DU
Ying
Y
Chang
Ke-liang
KL
Song
Lai-jun
LJ
Hu
Xiang
X
Zeng
Guang-wei
GW
D000650:Amnion / Q000166:cytology*; D000818:Animals; D001930:Brain Injuries / Q000628:therapy*; D005260:Female; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology*; D009416:Nerve Regeneration / Q000502:physiology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar