Circulating endotoxin and systemic immune activation in sporadic amyotrophic lateral sclerosis (sALS).
The present study reports elevated levels of endotoxin/lipopolysaccharide (LPS) concentrations in plasma from patients with sporadic amyotrophic lateral sclerosis (sALS) and Alzheimer's (AD) as compared to healthy controls. Levels of plasma LPS showed a significant positive correlation with degree of blood monocyte/macrophage activation in disease groups and was most elevated in patients with advanced sALS disease. There was a significant negative relationship between plasma LPS and levels of monocyte/macrophage IL-10 expression in sALS blood. These data suggest that systemic LPS levels and activated monocyte/macrophages may play significant roles in the pathogenesis of sALS.
Zhang
Rongzhen
R
University of California, San Francisco, San Francisco, CA 94110, USA.
Miller
Robert G
RG
Gascon
Ron
R
Champion
Stacey
S
Katz
Jonathan
J
Lancero
Mariselle
M
Narvaez
Amy
A
Honrada
Ronald
R
Ruvalcaba
David
D
McGrath
Michael S
MS
D000368:Aged; D000544:Alzheimer Disease / Q000097:blood; D000690:Amyotrophic Lateral Sclerosis / Q000097:blood* / Q000276:immunology* / Q000473:pathology; D000704:Analysis of Variance; D004731:Endotoxins / Q000097:blood*; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D006684:HLA-DR Antigens / Q000378:metabolism; D006801:Humans; D016753:Interleukin-10 / Q000378:metabolism; D008070:Lipopolysaccharides / Q000097:blood*; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology / Q000378:metabolism
D004731:Endotoxins; D006684:HLA-DR Antigens; D008070:Lipopolysaccharides; D016753:Interleukin-10