title: Beta-catenin-mediated Wnt signaling regulates neurogenesis in the ventral telencephalon.
abstract: Development of the telencephalon involves the coordinated growth of diversely patterned brain structures. Previous studies have demonstrated the importance of beta-catenin-mediated Wnt signaling in proliferation and fate determination during cerebral cortical development. We found that beta-catenin-mediated Wnt signaling critically maintained progenitor proliferation in the subcortical (pallidal) telencephalon. Targeted deletion of beta-catenin in mice severely impaired proliferation in the medial ganglionic eminence without grossly altering differentiated fate. Several lines of evidence suggest that this phenotype is primarily the result of a loss of canonical Wnt signaling. As previous studies have suggested that the ventral patterning factor Sonic Hedgehog (Shh) also stimulates dorsal telencephalic proliferation, we propose a model whereby Wnt and Shh signaling promote distinct dorsal-ventral patterning while also having broader effects on proliferation that serve to coordinate the growth of telencephalic subregions.
authors.affiliation: Department of Psychiatry, Weill Medical College of Cornell University, 1300 York Avenue, Box 244, New York, New York, 10065, USA.
authors.forename: Alexandra A
authors.initials: AA
authors.lastname: Gulacsi
authors.forename: Stewart A
authors.initials: SA
authors.lastname: Anderson
mesh_terms: D000367:Age Factors; D000818:Animals; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism; D019521:Body Patterning / Q000235:genetics; D001973:Bromodeoxyuridine / Q000378:metabolism; D064026:Calbindins; D002452:Cell Count / Q000379:methods; D049109:Cell Proliferation; D002478:Cells, Cultured; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D018274:Electroporation / Q000379:methods; D004622:Embryo, Mammalian; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D049452:Green Fluorescent Proteins / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology; D019394:Ki-67 Antigen / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D009419:Nerve Tissue Proteins / Q000378:metabolism; D055495:Neurogenesis / Q000187:drug effects / Q000502:physiology*; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D009924:Organ Culture Techniques / Q000379:methods; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D064030:S100 Calcium Binding Protein G / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D013234:Stem Cells / Q000187:drug effects / Q000502:physiology; D051820:TCF Transcription Factors / Q000378:metabolism; D013687:Telencephalon / Q000166:cytology* / Q000502:physiology*; D000074482:Thyroid Nuclear Factor 1; D000073940:Transcription Factor 4; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D051153:Wnt Proteins / Q000378:metabolism*; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism*
chemical_list: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D051792:Basic Helix-Loop-Helix Proteins; D001973:Bromodeoxyuridine; D064026:Calbindins; D002795:Choline O-Acetyltransferase; D049452:Green Fluorescent Proteins; D036341:Intercellular Signaling Peptides and Proteins; D019394:Ki-67 Antigen; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D018809:Proliferating Cell Nuclear Antigen; D064030:S100 Calcium Binding Protein G; D051820:TCF Transcription Factors; D000074482:Thyroid Nuclear Factor 1; D000073940:Transcription Factor 4; D014157:Transcription Factors; D051153:Wnt Proteins; D051176:beta Catenin; C499317:Ascl1 protein, mouse; C495267:CTNNB1 protein, mouse; C501127:Dkk1 protein, mouse; C090743:Tcf4 protein, mouse