title: Antimicrobial activities of 3-amino- and polyaminosterol analogues of squalamine and trodusquemine.
abstract: A series of 3-amino- and polyaminosterol analogues of squalamine and trodusquemine were synthesized and evaluated for their in vitro antimicrobial properties against human pathogens. The activity was highly dependent on the structure of the different compounds involved and the best results were obtained with aminosterol derivatives 4b, 4e, 8b, 8e and 8n exhibiting minimum inhibitory concentrations (MICs) against yeasts, Gram positive and Gram negative bacteria at average concentrations of 3.12-12.5 microM.
authors.affiliation: Laboratoire SESNAB, UMR-MD1, case 342, Faculté de St Jérome, Université de Méditerranée, Marseille, Cedex 20, France.
authors.forename: Chanaz
authors.initials: C
authors.lastname: Salmi
authors.forename: Celine
authors.initials: C
authors.lastname: Loncle
authors.forename: Nicolas
authors.initials: N
authors.lastname: Vidal
authors.forename: Michéle
authors.initials: M
authors.lastname: Laget
authors.forename: Yves
authors.initials: Y
authors.lastname: Letourneux
authors.forename: Jean Michel
authors.initials: JM
authors.lastname: Brunel
mesh_terms: D000588:Amines / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002776:Cholestanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002777:Cholestanols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D050296:Microbial Viability / Q000187:drug effects; D015394:Molecular Structure; D013096:Spermine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013261:Sterols / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: C441128:3-N-1(spermine)-7, 24-dihydroxy-5-cholestane 24-sulfate; D000588:Amines; D000900:Anti-Bacterial Agents; D002776:Cholestanes; D002777:Cholestanols; D013261:Sterols; D013096:Spermine; C079655:squalamine