The SNPMaP package for R: a framework for genome-wide association using DNA pooling on microarrays.
Large-scale genome-wide association (GWA) studies using thousands of high-density SNP microarrays are becoming an essential tool in the search for loci related to heritable variation in many phenotypes. However, the cost of GWA remains beyond the reach of many researchers. Fortunately, the majority of statistical power can still be obtained by estimating allele frequencies from DNA pools, reducing the cost to that of tens, rather than thousands of arrays. We present a set of software tools for processing SNPMaP (SNP microarrays and pooling) data from CEL files to Relative Allele Scores in the rich R statistical computing environment.
Davis
Oliver S P
OS
Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK. snpmap@iop.kcl.ac.uk
Plomin
Robert
R
Schalkwyk
Leonard C
LC
D004247:DNA / Q000737:chemistry; D005787:Gene Frequency; D016678:Genome; D055106:Genome-Wide Association Study / Q000379:methods*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D020641:Polymorphism, Single Nucleotide; D012984:Software
D004247:DNA