title: From sponges to capsules. The history of esophageal pH monitoring.
abstract: The understanding of digestive physiology, gastric acid production, and gastroesophageal reflux disease has been evolving since the 16th century. During this time, several methods to detect gastric refluxate were ingeniously developed. Ambulatory esophageal pH monitoring is still the current gold standard test for the diagnosis of gastroesophageal reflux disease. State-of-the-art technologies use catheter-free wireless pH sensors, an idea first conceived in the 1950s. The authors reviewed the history of esophageal pH monitoring.
authors.affiliation: Department of Surgery, Federal University of Sao Paulo, SP, Brazil. herbella.dcir@epm.br
authors.forename: Fernando A M
authors.initials: FA
authors.lastname: Herbella
authors.forename: Ian
authors.initials: I
authors.lastname: Nipominick
authors.forename: Marco G
authors.initials: MG
authors.lastname: Patti
mesh_terms: D005762:Gastroenterology / Q000266:history; D005764:Gastroesophageal Reflux / Q000175:diagnosis; D049669:History, 16th Century; D049671:History, 18th Century; D049672:History, 19th Century; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008991:Monitoring, Physiologic / Q000266:history*