Two pediatric cases of nonbullous histiocytoid neutrophilic dermatitis presenting as a cutaneous manifestation of lupus erythematosus.
BACKGROUND
Nonbullous neutrophilic dermatoses are seen infrequently in association with lupus erythematosus (LE). A recently described histopathologic variant of Sweet syndrome, to our knowledge, histiocytoid Sweet syndrome (HSS) has not been described in either pediatric or adult patients with LE.


METHODS
We describe 2 pediatric patients with nonbullous histiocytoid neutrophilic dermatitis in the setting of LE. One case represents the initial presentation of subacute cutaneous LE, while the other case represents a manifestation of established systemic LE. Both cases demonstrate histopathologic findings of HSS.


CONCLUSIONS
We believe that the dermatosis observed in these 2 patients represents a nonbullous histiocytoid neutrophilic dermatosis that is best termed HSS. This entity may represent a distinct and important cutaneous manifestation of LE. Additional study is needed to further elucidate the relationship between neutrophilic dermatitis and LE.
Camarillo
Diana
D
Department of Dermatology, University of California, San Francisco, USA.
McCalmont
Timothy H
TH
Frieden
Ilona J
IJ
Gilliam
Amy E
AE
D001707:Biopsy, Needle; D002648:Child; D002675:Child, Preschool; D003872:Dermatitis / Q000175:diagnosis / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008178:Lupus Erythematosus, Cutaneous / Q000175:diagnosis / Q000473:pathology*; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000473:pathology*; D009504:Neutrophils / Q000473:pathology; D018570:Risk Assessment; D016463:Sweet Syndrome / Q000175:diagnosis / Q000473:pathology*