Digest this! A role for autophagy in controlling pathogens.
Autophagy provides a mechanism for cells to conserve nutrients, but was recently associated with immunity to intracellular pathogens. Here, Zhao et al. (2008) present direct in vivo evidence that autophagy is linked to macrophage control of Toxoplasma gondii and Listeria monocytogenes and highlights that this process intersects with cytokine-mediated antimicrobial responses.
Whitmarsh
Ryan J
RJ
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 380 South University Avenue, Philadelphia, PA 19104, USA.
Hunter
Christopher A
CA
D000818:Animals; D001343:Autophagy; D000071187:Autophagy-Related Protein 5; D054884:Host-Pathogen Interactions; D006801:Humans; D008089:Listeria monocytogenes / Q000502:physiology*; D008088:Listeriosis / Q000276:immunology* / Q000382:microbiology; D008264:Macrophages / Q000276:immunology* / Q000469:parasitology; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000276:immunology*; D014122:Toxoplasma / Q000502:physiology*; D014123:Toxoplasmosis / Q000276:immunology* / Q000469:parasitology
C495773:Atg5 protein, mouse; D000071187:Autophagy-Related Protein 5; D008869:Microtubule-Associated Proteins