title: Cost-effectiveness analysis for joint pain treatment in patients with osteoarthritis treated at the Instituto Mexicano del Seguro Social (IMSS): Comparison of nonsteroidal anti-inflammatory drugs (NSAIDs) vs. cyclooxygenase-2 selective inhibitors.
abstract: BACKGROUND
  Osteoarthritis (OA) is one of the main causes of disability worldwide, especially in persons >55 years of age. Currently, controversy remains about the best therapeutic alternative for this disease when evaluated from a cost-effectiveness viewpoint. For Social Security Institutions in developing countries, it is very important to assess what drugs may decrease the subsequent use of medical care resources, considering their adverse events that are known to have a significant increase in medical care costs of patients with OA. Three treatment alternatives were compared: celecoxib (200 mg twice daily), non-selective NSAIDs (naproxen, 500 mg twice daily; diclofenac, 100 mg twice daily; and piroxicam, 20 mg/day) and acetaminophen, 1000 mg twice daily. The aim of this study was to identify the most cost-effective first-choice pharmacological treatment for the control of joint pain secondary to OA in patients treated at the Instituto Mexicano del Seguro Social (IMSS).
  
  
  METHODS
  A cost-effectiveness assessment was carried out. A systematic review of the literature was performed to obtain transition probabilities. In order to evaluate analysis robustness, one-way and probabilistic sensitivity analyses were conducted. Estimations were done for a 6-month period.
  
  
  RESULTS
  Treatment demonstrating the best cost-effectiveness results [lowest cost-effectiveness ratio $17.5 pesos/patient ($1.75 USD)] was celecoxib. According to the one-way sensitivity analysis, celecoxib would need to markedly decrease its effectiveness in order for it to not be the optimal treatment option. In the probabilistic analysis, both in the construction of the acceptability curves and in the estimation of net economic benefits, the most cost-effective option was celecoxib.
  
  
  CONCLUSIONS
  From a Mexican institutional perspective and probably in other Social Security Institutions in similar developing countries, the most cost-effective option for treatment of knee and/or hip OA would be celecoxib.
authors.affiliation: Unidad de Investigación en Economía de la Salud, Instituto Mexicano del Seguro Social, Mexico, D,F, Mexico.
authors.forename: Iris
authors.initials: I
authors.lastname: Contreras-Hernández
authors.forename: Joaquín F
authors.initials: JF
authors.lastname: Mould-Quevedo
authors.forename: Rubén
authors.initials: R
authors.lastname: Torres-González
authors.forename: María Victoria
authors.initials: MV
authors.lastname: Goycochea-Robles
authors.forename: Reyna Lizette
authors.initials: RL
authors.lastname: Pacheco-Domínguez
authors.forename: Sergio
authors.initials: S
authors.lastname: Sánchez-García
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Mejía-Aranguré
authors.forename: Juan
authors.initials: J
authors.lastname: Garduño-Espinosa