2-Azetidinone derivatives: design, synthesis and evaluation of cholesterol absorption inhibitors.
Fourteen new derivatives of the 2-azetidinone cholesterol absorption inhibitors have been synthesized, and three of them were enantiomerically pure. All the new compounds were evaluated for their activity to inhibit cholesterol absorption in rats, and most of them showed comparable effects in lowering the levels of total cholesterol in the serum.
Wang
Yubin
Y
New Drug Research Center, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China.
Zhang
Huibin
H
Huang
Wenlong
W
Kong
Jing
J
Zhou
Jinpei
J
Zhang
Beibei
B
D000042:Absorption / Q000187:drug effects; D000818:Animals; D001384:Azetidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002784:Cholesterol / Q000378:metabolism*; D006224:Cricetinae; D015195:Drug Design; D008297:Male
C116379:2-azetidinone; D001384:Azetidines; D002784:Cholesterol