title: [Team-based medical care can improve tailor made chemotherapy for colorectal cancer].
abstract: We report that team-based medical care has an important role in tailor made chemotherapy for colorectal cancer. We organized a chemotherapy support team to facilitate the early detection of toxicity and to get hold of therapeutic needs in individual patients. We also measured the circadian variation of 5-fluorouracil plasma concentrations to permit tailor dosed chemotherapy. To date, the chemotherapy support team has managed the performance of pharmacokinetic modulating chemotherapy in 30 patients with unresectable or recurrent colorectal cancer. The median survival time was 19 months after the first-line chemotherapy and 14 months after the second-line treatment. Our results suggest that team-based medical care is practically useful for tailor made chemotherapy in patients with colorectal cancer.
authors.affiliation: Dept. of Surgery, Niitsu Medical Center Hospital.
authors.forename: Katsuki
authors.initials: K
authors.lastname: Muneoka
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Shirai
authors.forename: Masataka
authors.initials: M
authors.lastname: Sasaki
authors.forename: Junkichi
authors.initials: J
authors.lastname: Kanda
authors.forename: Toshinari
authors.initials: T
authors.lastname: Asakura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Wakabayashi
authors.forename: Muneatsu
authors.initials: M
authors.lastname: Toshima
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Hatakeyama
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000523:psychology; D004334:Drug Administration Schedule; D005260:Female; D005502:Food; D006801:Humans; D008297:Male; D008875:Middle Aged; D005791:Patient Care; D011795:Surveys and Questionnaires
chemical_list: D000970:Antineoplastic Agents