Determinants of unplanned antiretroviral treatment interruptions among people living with HIV in Yaoundé, Cameroon (EVAL survey, ANRS 12-116).
OBJECTIVE
To identify correlates of self-reported antiretroviral therapies (ART) interruptions among people living with HIV and AIDS (PLWHA) in Cameroon.


METHODS
Analyses were based on data collected in the national survey EVAL (ANRS 12-116) among 533 ART-treated PLWHA in Yaoundé, the capital city of Cameroon, and its neighbourhood. Logistic regression models were used to identify factors associated with self-reported ART interruptions longer than two consecutive days during the previous 4 weeks.


RESULTS
ART interruptions were reported by 68 patients (12.8%). After adjustment for gender, education and household income, characteristics independently associated with interruptions were pharmacy stock shortages [OR (95%CI):3.25 (1.78-5.90)], binge drinking [2.87 (1.39-5.91)] and the number of self-reported slimming symptoms [1.23 (1.02-1.48)].


CONCLUSIONS
In poor-resource settings where access to second and third-line regimens is still limited, food supply programs and interventions to minimise ART shortage may reduce the risk of ART interruptions.
Marcellin
Fabienne
F
INSERM U912/ORS PACA, 23 rue Stanislas Torrents, 13006 Marseille, France. fabienne.marcellin@inserm.fr
Boyer
Sylvie
S
Protopopescu
Camelia
C
Dia
Aissata
A
Ongolo-Zogo
Pierre
P
Koulla-Shiro
Sinata
S
Abega
Séverin-Cécile
SC
Abé
Claude
C
Moatti
Jean-Paul
JP
Spire
Bruno
B
Carrieri
Maria Patrizia
MP
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy; D000328:Adult; D000428:Alcohol Drinking; D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000600:supply & distribution / Q000627:therapeutic use; D002163:Cameroon; D003430:Cross-Sectional Studies; D004334:Drug Administration Schedule; D005260:Female; D005523:Food Supply; D015658:HIV Infections / Q000188:drug therapy*; D006306:Health Surveys; D006801:Humans; D016015:Logistic Models; D008297:Male; D010349:Patient Compliance / Q000706:statistics & numerical data*
D019380:Anti-HIV Agents