title: Poly(vinyl alcohol)-acrylamide hydrogels as load-bearing cartilage substitute.
abstract: Poly(vinyl alcohol) (PVA) has been advanced as a biomaterial for the fabrication of medical devices to be used as synthetic articular cartilage because of its viscoelastic nature, high water content, and biocompatibility. Key material requirements for such devices are high creep resistance to prevent mechanical instability in the joint and high water content to maintain a lubricious surface to minimize wear and damage of the cartilage counterface during articulation. The creep resistance of PVA hydrogels can be increased by high temperature annealing; however this process also collapses the pores, reducing the water content and consequently reducing the lubricity of the hydrogel surface [Bodugoz-Senturk H, Choi J, Oral E, Kung JH, Macias CE, Braithwaite G, et al. The effect of polyethylene glycol on the stability of pores in polyvinyl alcohol hydrogels during annealing. Biomaterials 2008;29(2):141-9.]. We hypothesized that polymerizing acrylamide (AAm) in the pores of the PVA hydrogel would minimize the loss of lubricity during annealing by preventing the collapse of the pores and loss of water content. Increasing AAm content increased porosity and equilibrium water content and decreased the coefficient of friction, tear strength, crystallinity, and creep resistance in annealed PVA hydrogels.
authors.affiliation: Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.
authors.forename: Hatice
authors.initials: H
authors.lastname: Bodugoz-Senturk
authors.forename: Celia E
authors.initials: CE
authors.lastname: Macias
authors.forename: Jean H
authors.initials: JH
authors.lastname: Kung
authors.forename: Orhun K
authors.initials: OK
authors.lastname: Muratoglu
mesh_terms: D020106:Acrylamide / Q000737:chemistry*; D002356:Cartilage / Q000502:physiology*; D055595:Mechanical Phenomena; D018613:Microscopy, Confocal; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D018709:Statistics, Nonparametric; D014867:Water; D016474:Weight-Bearing; D014961:X-Ray Diffraction
chemical_list: C062364:polyvinyl alcohol hydrogel; D014867:Water; D020106:Acrylamide; D011142:Polyvinyl Alcohol