Detection and quantification of magnetically labeled cells by cellular MRI.
Labeling cells with superparamagnetic iron oxide (SPIO) nanoparticles, paramagnetic contrast agent (gadolinium) or perfluorocarbons allows for the possibility of tracking single or clusters of labeled cells within target tissues following either direct implantation or intravenous injection. This review summarizes the practical issues regarding detection and quantification of magnetically labeled cells with various MRI contrast agents with a focus on SPIO nanoparticles.
Liu
Wei
W
Philips Research North America, Briarcliff Manor, NY 10510, USA.
Frank
Joseph A
JA
D002478:Cells, Cultured / Q000166:cytology*; D003287:Contrast Media / Q000737:chemistry*; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008280:Magnetics / Q000379:methods*; D013194:Staining and Labeling / Q000379:methods*
D003287:Contrast Media