title: In vivo (19)F MRI and (19)F MRS of (19)F-labelled boronophenylalanine-fructose complex on a C6 rat glioma model to optimize boron neutron capture therapy (BNCT).
abstract: Boron neutron capture therapy (BNCT) is a promising binary modality used to treat malignant brain gliomas. To optimize BNCT effectiveness a non-invasive method is needed to monitor the spatial distribution of BNCT carriers in order to estimate the optimal timing for neutron irradiation. In this study, in vivo spatial distribution mapping and pharmacokinetics evaluation of the (19)F-labelled boronophenylalanine (BPA) were performed using (19)F magnetic resonance imaging ((19)F MRI) and (19)F magnetic resonance spectroscopy ((19)F MRS). Characteristic uptake of (19)F-BPA in C6 glioma showed a maximum at 2.5 h after compound infusion as confirmed by both (19)F images and (19)F spectra acquired on blood samples collected at different times after infusion. This study shows the ability of (19)F MRI to selectively map the bio-distribution of (19)F-BPA in a C6 rat glioma model, as well as providing a useful method to perform pharmacokinetics of BNCT carriers.
authors.affiliation: CNR-INFM SOFT, Physics Department, University of Rome "Sapienza", Rome, Italy. paola.porcari@roma1.infn.it
authors.forename: Paola
authors.initials: P
authors.lastname: Porcari
authors.forename: Silvia
authors.initials: S
authors.lastname: Capuani
authors.forename: Emanuela
authors.initials: E
authors.lastname: D'Amore
authors.forename: Mario
authors.initials: M
authors.lastname: Lecce
authors.forename: Angela
authors.initials: A
authors.lastname: La Bella
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Fasano
authors.forename: Renzo
authors.initials: R
authors.lastname: Campanella
authors.forename: Luisa Maria
authors.initials: LM
authors.lastname: Migneco
authors.forename: Francesco Saverio
authors.initials: FS
authors.lastname: Pastore
authors.forename: Bruno
authors.initials: B
authors.lastname: Maraviglia
mesh_terms: D000818:Animals; D001896:Boron Compounds / Q000493:pharmacokinetics; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D001921:Brain / Q000378:metabolism / Q000473:pathology; D001932:Brain Neoplasms / Q000378:metabolism / Q000532:radiotherapy; D045744:Cell Line, Tumor; D003710:Demography; D005462:Fluorine Radioisotopes / Q000097:blood; D005632:Fructose / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D005910:Glioma / Q000378:metabolism / Q000532:radiotherapy*; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009374:Neoplasms, Experimental / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar
chemical_list: C089739:4-boronophenylalanine-fructose; D001896:Boron Compounds; D005462:Fluorine Radioisotopes; D005632:Fructose