Pt2L4 protein, a homologue to Hev b 5 from rubber tree, may not be responsible for the cross-reactions to cassava show by people allergic to latex.
Pt2L4 is a protein from cassava homologue to Hevb5, a principal allergen from latex. Here we aimed to elucidate immunological relationships between these proteins. Our results revealed that epitopes found in Hev b 5 are not entirely conserved in Pt2L4 which is not recognized by IgE from patients allergic to Hev b 5.
de Souza
Cláudia Regina Batista
CR
EMBRAPA Recursos Geneticos e Biotecnologia, Brasília-DF, 70770-900, Brazil. bsouza@ufpa.br
Beezhold
Donald
D
Carvalho
Luiz Joaquim C Branco
LJ
D000485:Allergens / Q000737:chemistry / Q000276:immunology*; D000595:Amino Acid Sequence; D052179:Antigens, Plant; D015153:Blotting, Western; D003429:Cross Reactions; D000939:Epitopes / Q000276:immunology; D018698:Glutamic Acid; D028482:Hevea / Q000737:chemistry / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007840:Latex / Q000276:immunology; D020315:Latex Hypersensitivity / Q000276:immunology*; D002365:Manihot / Q000737:chemistry* / Q000276:immunology; D008969:Molecular Sequence Data; D010940:Plant Proteins / Q000737:chemistry / Q000276:immunology*; D018517:Plant Roots / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D040681:Structural Homology, Protein
D000485:Allergens; D052179:Antigens, Plant; D000939:Epitopes; D007074:Immunoglobulin G; D007840:Latex; D010940:Plant Proteins; C101800:allergen Hev b 5; D018698:Glutamic Acid