title: Genetics of susceptibility to malaria related phenotypes.
abstract: Previous studies have established a genetic component for susceptibility to malaria. Here we use a pedigree based approach, and transmission disequilibrium testing (TDT), to identify immune response genes that influence susceptibility to Plasmodium falciparum malarial phenotypes (parasite density and frequency of clinical episodes) in a Tanzanian population. Evidence for association was observed between markers in the TNF gene cluster and both the malarial phenotypes. There was weaker evidence for associations between HLA-DRB1*04, HLA-DRB1*10, and loci in the TCRBV region with parasite density. There was no evidence for association with polymorphisms in the IL10 promoter, IL1 gene cluster, or from the IL4/IL13 region.
authors.affiliation: Faculty of Biological Sciences, Institute of Integrative and Comparative Biology, University of Leeds, Leeds, UK. danielle.carpenter@nottingham.ac.uk
authors.forename: Danielle
authors.initials: D
authors.lastname: Carpenter
authors.forename: Ingegerd
authors.initials: I
authors.lastname: Rooth
authors.forename: Anna
authors.initials: A
authors.lastname: Färnert
authors.forename: Hind
authors.initials: H
authors.lastname: Abushama
authors.forename: Rupert J
authors.initials: RJ
authors.lastname: Quinnell
authors.forename: Marie-Anne
authors.initials: MA
authors.lastname: Shaw
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003627:Data Interpretation, Statistical; D005260:Female; D020022:Genetic Predisposition to Disease; D006681:HLA-D Antigens / Q000097:blood / Q000235:genetics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016753:Interleukin-10 / Q000097:blood / Q000235:genetics; D007378:Interleukins / Q000097:blood / Q000235:genetics; D015810:Linkage Disequilibrium; D008137:Longitudinal Studies; D016778:Malaria, Falciparum / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D018512:Parasitemia; D010375:Pedigree; D010641:Phenotype; D011110:Polymorphism, Genetic; D013636:Tanzania; D014409:Tumor Necrosis Factor-alpha / Q000097:blood / Q000235:genetics
chemical_list: D015415:Biomarkers; D006681:HLA-D Antigens; D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10