Fetal methotrexate/aminopterin syndrome in an adult: a likely case with ectodermal abnormalities.
Exposure to folic acid antagonists during the first trimester of pregnancy may lead to fetal death or to a recognized pattern of malformations in liveborn infants. Few reports of affected adult individuals have been observed. In this report, the clinical findings of a likely affected 45-year-old woman are described and compared with reported cases. New ectodermal abnormalities are also described.
Aftimos
Salim
S
Northern Regional Genetic Service, Auckland City Hospital, Auckland, New Zealand.
D000028:Abortion, Induced / Q000009:adverse effects*; D000630:Aminopterin / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007621:Karyotyping; D008727:Methotrexate / Q000008:administration & dosage*; D008875:Middle Aged; D013577:Syndrome
D000630:Aminopterin; D008727:Methotrexate