title: Polychlorinated dibenzo-p-dioxins/furans and polychlorinated biphenyls in human adipose tissue from Zhejiang Province, China.
abstract: This is the first report on polychlorinated dibenzo-p-dioxin/furan (PCDD/F) and polychlorinated biphenyl (PCB) contamination of human adipose tissue from China. A total of 24 human adipose tissue samples from a general population in Zhejiang Province were analyzed for PCDD/F and PCB by high-resolution gas chromatography-high-resolution mass spectrometry. Total PCDD/F concentrations in human adipose tissue ranged from 33.9 to 504 pg g(-1)lipid (mean 108 pg g(-1)lipid). Corresponding values for dioxin-like PCBs ranged from 4.1 to 125 ng g(-1)lipid (mean 32.8 ng g(-1)lipid). Mean total WHO toxicity equivalent (TEQ) values for PCDD/Fs and PCBs in human adipose tissue were 9.22 and 16.2 pg g(-1)lipid, respectively. OCDD was the dominant PCDD/F congener, and 2,3,4,7,8-PeCDF and 1,2,3,7,8-PeCDD accounted for more than 70% of the WHO PCDD/F TEQ. In all samples, PCB-118, PCB-156 and PCB-105 were the main PCB congeners. PCB-153 concentrations were the highest of all indicator PCBs (mean 52.5 ng g(-1)lipid). The contamination levels and profiles are compared with those reported for European and Asian countries.
authors.affiliation: Zhejiang Provincial Center for Disease Prevention and Control, 630 Xin Cheng Road, Binjiang District, Hangzhou 310051, China. oldfishmann@hotmail.com
authors.forename: Haitao
authors.initials: H
authors.lastname: Shen
authors.forename: Jianlong
authors.initials: J
authors.lastname: Han
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Tie
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.forename: Yiping
authors.initials: Y
authors.lastname: Ren
authors.forename: Chunsheng
authors.initials: C
authors.lastname: Ye
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry* / Q000378:metabolism; D002681:China; D004785:Environmental Pollutants / Q000032:analysis* / Q000378:metabolism / Q000633:toxicity; D005663:Furans / Q000032:analysis* / Q000378:metabolism / Q000633:toxicity; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D011078:Polychlorinated Biphenyls / Q000032:analysis* / Q000378:metabolism / Q000633:toxicity; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000032:analysis / Q000378:metabolism / Q000633:toxicity; D018570:Risk Assessment
chemical_list: D004785:Environmental Pollutants; D005663:Furans; D000072317:Polychlorinated Dibenzodioxins; D011078:Polychlorinated Biphenyls