title: Cofilin immunolabelling correlates with depth of invasion in gastrointestinal endocrine cell tumors.
abstract: Gastrointestinal endocrine cell tumors are a heterogeneous population of lesions believed to arise from neuroendocrine cells of the gastrointestinal mucosa. The current classification of these tumors is based on tumor size, microscopic features and clinical evidence of metastasis. Although diagnostic categories generally correlate with prognosis, molecular prognostic markers will be clinically useful adjuncts. Cofilin has been implicated in tumor invasion, and its immunolocalisation was studied in gastrointestinal endocrine cell tumors. The immunolocalisation of cofilin was studied by immunohistochemistry in 34 formalin-fixed, paraffin wax-embedded gastrointestinal endocrine cell tumors using a tissue microarray platform. A significant correlation was found between high cofilin immunolabelling and the depth of invasion (p<0.05). Our findings suggest that cofilin might be useful clinically as a molecular prognostic adjunct in the evaluation of gastrointestinal endocrine cell tumors.
authors.affiliation: Department of Pathology, National University Hospital and Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Benedict
authors.initials: B
authors.lastname: Yan
authors.forename: Celestial T
authors.initials: CT
authors.lastname: Yap
authors.forename: Shi
authors.initials: S
authors.lastname: Wang
authors.forename: Chi Kuen
authors.initials: CK
authors.lastname: Lee
authors.forename: Shiuan
authors.initials: S
authors.lastname: Koh
authors.forename: Mohd Feroz
authors.initials: MF
authors.lastname: Omar
authors.forename: Manuel
authors.initials: M
authors.lastname: Salto-Tellez
authors.forename: Marian Priyanthi
authors.initials: MP
authors.lastname: Kumarasinghe
mesh_terms: D051339:Actin Depolymerizing Factors / Q000378:metabolism*; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002277:Carcinoma / Q000378:metabolism / Q000473:pathology; D004701:Endocrine Gland Neoplasms / Q000378:metabolism* / Q000473:pathology*; D019858:Enteroendocrine Cells / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000378:metabolism / Q000473:pathology; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology; D055815:Young Adult
chemical_list: D051339:Actin Depolymerizing Factors; D014408:Biomarkers, Tumor