Nephrogenic systemic fibrosis with multiple calcification and osseous metaplasia.
We describe here a 50-year-old Japanese man with nephrogenic systemic fibrosis. He had been suffering from chronic renal insufficiency and had been treated with haemodialysis. He had undergone magnetic resonance angiography using gadodiamide 7 years previously. One month after magnetic resonance angiography, he noted swelling, hotness, induration and pain in his left arm. The same symptoms gradually spread over his lower extremities, resulting in flexion contractures with limited range of motion. Physical examination revealed skin sclerosis on his extremities with a glossy brownish skin surface. Histologically, increased collagen fibres with high cellularity were seen in the dermis and subcutaneous septa. Thickened fascia was also noted, as well as osseous metaplasia under the fascia. Computed tomography of the whole body revealed multiple calcification of the fascia in many muscles. Treatment with intravenous sodium thiosulphate did not result in any clinical improvement.
Nagai
Yayoi
Y
Department of Dermatology, Gunma University Graduate School of Medicine, Gunma, Japan. yanagai@showa.gunma-u.ac.jp
Hasegawa
Michiko
M
Shinmi
Kahori
K
Kishi
Chikako
C
Tsushima
Yoshito
Y
Endo
Keigo
K
Okabe
Kazuhiko
K
Suzuki
Kazuhiro
K
Ishikawa
Osamu
O
D000328:Adult; D002114:Calcinosis / Q000000981:diagnostic imaging*; D003287:Contrast Media / Q000009:adverse effects*; D005205:Fascia / Q000000981:diagnostic imaging; D019786:Gadolinium DTPA / Q000009:adverse effects*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation; D018810:Magnetic Resonance Angiography; D008297:Male; D009135:Muscular Diseases / Q000000981:diagnostic imaging*; D054989:Nephrogenic Fibrosing Dermopathy / Q000139:chemically induced* / Q000175:diagnosis; D009999:Ossification, Heterotopic / Q000000981:diagnostic imaging*; D006435:Renal Dialysis; D014057:Tomography, X-Ray Computed
D003287:Contrast Media; C064925:gadodiamide; D019786:Gadolinium DTPA