The human papillomavirus E7 oncoprotein.
The human papillomavirus (HPV) E7 oncoprotein shares functional similarities with such proteins as adenovirus E1A and SV40 large tumor antigen. As one of only two viral proteins always expressed in HPV-associated cancers, E7 plays a central role in both the viral life cycle and carcinogenic transformation. In the HPV viral life cycle, E7 disrupts the intimate association between cellular differentiation and proliferation in normal epithelium, allowing for viral replication in cells that would no longer be in the dividing population. This function is directly reflected in the transforming activities of E7, including tumor initiation and induction of genomic instability.
McLaughlin-Drubin
Margaret E
ME
Brigham and Women's Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. mdrubin@rics.bwh.harvard.edu
Münger
Karl
K
D016923:Cell Death; D002454:Cell Differentiation; D049109:Cell Proliferation; D002472:Cell Transformation, Viral; D043171:Chromosomal Instability; D016207:Cytokines / Q000378:metabolism; D050684:E2F Transcription Factors / Q000378:metabolism; D044127:Epigenesis, Genetic; D027383:Papillomaviridae / Q000378:metabolism* / Q000502:physiology; D050725:Papillomavirus E7 Proteins / Q000378:metabolism*; D030361:Papillomavirus Infections / Q000821:virology; D016160:Retinoblastoma Protein / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D014779:Virus Replication
D016207:Cytokines; D050684:E2F Transcription Factors; D050725:Papillomavirus E7 Proteins; D016160:Retinoblastoma Protein; D016159:Tumor Suppressor Protein p53