In-vivo singlet oxygen dosimetry of clinical 5-aminolevulinic acid photodynamic therapy.
Photodynamic therapy (PDT) is a viable treatment option for a wide range of applications, including oncology, dermatology, and ophthalmology. Singlet oxygen is believed to play a key role in the efficacy of PDT, and on-line monitoring of singlet oxygen during PDT could provide a methodology to establish and customize the treatment dose clinically. This work is the first report of monitoring singlet oxygen luminescence in vivo in human subjects during PDT, demonstrating the correlation of singlet oxygen levels during PDT with the post-PDT photobiological response.
Laubach
Hans-Joachim
HJ
Massachusetts General Hospital, Wellman Center for Photomedicine, Boston, Massachusetts 02114, USA.
Chang
Sung K
SK
Lee
Seonkyung
S
Rizvi
Imran
I
Zurakowski
David
D
Davis
Steven J
SJ
Taylor
Charles R
CR
Hasan
Tayyaba
T
D000622:Aminolevulinic Acid / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008163:Luminescent Measurements / Q000379:methods*; D008297:Male; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage; D011874:Radiometry / Q000379:methods*; D026082:Singlet Oxygen / Q000032:analysis*; D012867:Skin / Q000187:drug effects* / Q000378:metabolism*
D017319:Photosensitizing Agents; D026082:Singlet Oxygen; D000622:Aminolevulinic Acid