Interaction between RANTES promoter variant and CCR5Delta32 favors recovery from hepatitis B.
Recovery from acute hepatitis B virus (HBV) infection occurs in 95% of adult-acquired infections. A 32-bp deletion in CCR5 (CCR5Delta32), which encodes for a nonfunctional receptor, increases the likelihood of recovery. Using 181 subjects with persistent HBV infection and 316 who had recovered, we tested the hypothesis that an epistatic interaction between functional polymorphisms in RANTES (a CCR5 ligand) and CCR5 impacts recovery. Specific models designed to assess individual contributions of compound genotypes demonstrated that the only combination associated with recovery from an HBV infection was RANTES -403A with CCR5Delta32 (odds ratio 0.36, p = 0.02). Because the phenotypic consequence of -403A is reported to be higher levels of RANTES, we propose a model in which excess RANTES in combination with low CCR5 favors recovery from an HBV infection, which will require validation through functional testing.
Thio
Chloe L
CL
Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Astemborski
Jacquie
J
Thomas
Rasmi
R
Mosbruger
Timothy
T
Witt
Mallory D
MD
Goedert
James J
JJ
Hoots
Keith
K
Winkler
Cherie
C
Thomas
David L
DL
Carrington
Mary
M
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001483:Base Sequence / Q000235:genetics*; D018946:Chemokine CCL5 / Q000235:genetics* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004843:Epistasis, Genetic / Q000235:genetics / Q000276:immunology; D005260:Female; D006509:Hepatitis B / Q000235:genetics* / Q000276:immunology; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology; D006801:Humans; D008297:Male; D008957:Models, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics* / Q000276:immunology; D019713:Receptors, CCR5 / Q000235:genetics* / Q000276:immunology; D017384:Sequence Deletion / Q000235:genetics* / Q000276:immunology; D014481:United States
C483024:CCL5 protein, human; D018946:Chemokine CCL5; D019713:Receptors, CCR5