Interpretive categorical accuracy of fluoroquinolone reference broth microdilution MIC results when testing Streptococcus pneumoniae: selection of a surrogate testing agent.
The categorical agreement among MIC results for the fluoroquinolones tested (levofloxacin, moxifloxacin, gatifloxacin and gemifloxacin) was high (99.16-99.85%), and error rates were nil or very low when 1 compound was used as a surrogate for predicting susceptibility (not resistance) to another agent in the class. No error was observed when levofloxacin was selected as the group surrogate for pneumococcal testing.
Sader
Helio S
HS
JMI Laboratories, North Liberty, IA 52317, USA. helio-sader@jmilabs.com
Koeth
Laura M
LM
Poupard
James A
JA
Jones
Ronald N
RN
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D024841:Fluoroquinolones / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000379:methods*; D015203:Reproducibility of Results; D013296:Streptococcus pneumoniae / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones