title: Carriebowmide, a new cyclodepsipeptide from the marine cyanobacterium Lyngbya polychroa.
abstract: The new cyclodepsipeptide carriebowmide, which contains two rare amino acids, 3-amino-2-methylhexanoic acid and methionine sulfoxide, was isolated from the fish-deterrent lipophilic extract of the marine cyanobacterium Lyngbya polychroa, collected from the fore reef near the Smithsonian field station at Carrie Bow Cay, Belize. Its planar structure was determined by NMR spectroscopic techniques. The absolute stereochemistry of the hydroxy acid and all R-aminoacid-derived units was ascertained by chiral HPLC analysis of the acid hydrolysate. The stereochemistry of the beta-aminoacid moiety, 3-amino-2-methylhexanoic acid, was established by Marfey analysis of the acid hydrolysate.
authors.affiliation: Smithsonian Marine Station, 701 Seaway Drive, Fort Pierce, Florida 34949, USA.
authors.forename: Sarath P
authors.initials: SP
authors.lastname: Gunasekera
authors.forename: Raphael
authors.initials: R
authors.lastname: Ritson-Williams
authors.forename: Valerie J
authors.initials: VJ
authors.lastname: Paul
mesh_terms: D002851:Chromatography, High Pressure Liquid; D000458:Cyanobacteria / Q000737:chemistry*; D047630:Depsipeptides / Q000737:chemistry / Q000302:isolation & purification*; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D047630:Depsipeptides; C534638:carriebowmide