Lipase inhibitory activity in alcohol extracts of worldwide occurring plants and propolis.
In the search for lipase inhibitory agents, 144 alcohol plant extracts and propolis were screened for pancreatic lipase activity in vitro using methods with methylresorufin and triolein as substrates. Ethanol extracts of Linum usitatissimum (oil flax) and Helianthus annuus (sunflower seeds) showed the strongest lipase inhibitory actions with ID(50) values of 1:370 and 1:166, respectively.
Möller
Niels Peter
NP
Max Rubner-Institut, Federal Research Institute of Nutrition and Food (location Kiel), Department of Physiology and Biochemistry of Nutrition, Hermann-Weigmann-Str. 1, 24103 Kiel, Germany.
Roos
Nils
N
Schrezenmeir
Jürgen
J
D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D019597:Flax / Q000737:chemistry*; D006368:Helianthus / Q000737:chemistry*; D008049:Lipase / Q000037:antagonists & inhibitors*; D010936:Plant Extracts / Q000494:pharmacology*; D011429:Propolis / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D010936:Plant Extracts; D011429:Propolis; D008049:Lipase