A familial gastrointestinal cancer clinic: organization, aims and activities, 2004-2007.
BACKGROUND
Dedicated, organ-specific screening clinics have been shown to significantly reduce cancer morbidity and mortality.


OBJECTIVE
To establish a dedicated clinic for Clalit Health Service patients at high risk for hereditary gastrointestinal cancer and to provide them with clinical and genetic counseling, diagnostic screening and follow-up.


RESULTS
During the 3 years of the clinic's activity, 634 high risk families, including 3804 at-risk relatives, were evaluated. The most common conditions were hereditary colorectal syndromes, Lynch syndrome (n=259), undefined young-onset or familial colorectal cancer (n=214), familial adenomatous polyposis (n=55), and others (n=106). They entered follow-up protocols and 52 underwent surgical procedures.


CONCLUSIONS
Consistent public and professional education is needed to increase awareness of hereditary colorectal cancer and the possibility of family screening, early diagnosis and therapy. The public health services--i.e., the four health management organizations--should provide genetic testing for these patients who, at present, are required to pay for almost all of these available but costly tests. Dedicated colorectal surgical units are needed to provide the specialized therapeutic procedures needed by patients with familial colorectal cancer. Our future plans include adding psychosocial support for these at-risk patients and their families as well as preventive lifestyle and dietary intervention.
Rozen
Paul
P
Department of Gastroenterology, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel. paulro@clalit.org.il
Levi
Zohar
Z
Hazazi
Rachel
R
Barnes-Kedar
Inbal
I
Samuel
Ziona
Z
Vilkin
Alex
A
Niv
Yaron
Y
D003153:Community Health Services / Q000458:organization & administration*; D005190:Family; D005260:Female; D005500:Follow-Up Studies; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics; D005817:Genetic Counseling / Q000458:organization & administration; D020022:Genetic Predisposition to Disease; D006801:Humans; D007557:Israel / Q000453:epidemiology; D008297:Male; D008403:Mass Screening / Q000458:organization & administration; D009017:Morbidity / Q000639:trends; D010353:Patient Education as Topic; D012189:Retrospective Studies; D012307:Risk Factors