title: Adoptive precursor cell therapy to enhance immune reconstitution after hematopoietic stem cell transplantation in mouse and man.
abstract: Hematopoietic stem cell transplantation is a curative therapy for hematological malignancies. T cell deficiency following transplantation is a major cause of morbidity and mortality. In this review, we discuss adoptive transfer of committed precursor cells to enhance T cell reconstitution and improve overall prognosis after transplantation.
authors.affiliation: Department of Immunology, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA.
authors.forename: Amanda M
authors.initials: AM
authors.lastname: Holland
authors.forename: Johannes L
authors.initials: JL
authors.lastname: Zakrzewski
authors.forename: Gabrielle L
authors.initials: GL
authors.lastname: Goldberg
authors.forename: Arnab
authors.initials: A
authors.lastname: Ghosh
authors.forename: Marcel R M
authors.initials: MR
authors.lastname: van den Brink
mesh_terms: D000818:Animals; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods*; D051379:Mice; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*