Isomeric furanosesquiterpenes from the Portuguese marine sponge Fasciospongia sp.
This paper reports the chemical study of a sample of Fasciospongia sp. collected along the Atlantic Portuguese coast. Three new isomeric furanosesquiterpenes, isomicrocionin-3 ( 1), (-)-microcionin-1 ( 2), and (-)-isomicrocionin-1 ( 3), were isolated along with the known (-)- ent-pallescensin A ( 4) and (-)-pallescensin-1 ( 5) from the ethyl acetate-soluble portion of the methanolic extract. The structures of the new compounds were elucidated by extensive spectroscopic studies. (-)-Microcionin-1 ( 2) tested positive against several Gram-negative bacteria.
Gaspar
Helena
H
helena.gaspar@ineti.pt.
Santos
Susana
S
Carbone
Mariana
M
Rodrigues
Ana Isabel
AI
Uriz
Maria J
MJ
Savluchinske Feio
Sónia Murta
SM
Melck
Dominique
D
Humanes
Madalena
M
Gavagnin
Margherita
M
D000818:Animals; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification*; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D011174:Portugal; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism
D005663:Furans; D012717:Sesquiterpenes; C000604850:isomicrocionin-1; C000604849:isomicrocionin-3; C000604895:microcionin-1