Immunohistochemistry diagnosis of an ovarian dysgerminoma in one bitch.
An ovarian enlargement (diameter, 8 cm) was identified and surgically excised from a 5-year-old female dog. Microscopic examination of the multinodular neoplasm revealed sheets of polygonal neoplastic cells with large nuclei, frequent mitosis, necrosis and haemorrhage. Immunohistochemically, the neoplastic cells were positive for vimentin and alkaline phosphatase but were negative for CD3, CD79a, cytokeratin, alpha-fetoprotein, inhibin-alpha and S-100. The histopathological diagnosis of the mass was unilateral ovarian dysgerminoma.
Park
J K
JK
Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, Korea.
Goo
M J
MJ
Hong
I H
IH
Ki
M R
MR
Han
J Y
JY
Jeong
K S
KS
D000469:Alkaline Phosphatase / Q000032:analysis; D000818:Animals; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D004285:Dogs; D004407:Dysgerminoma / Q000175:diagnosis / Q000601:surgery / Q000662:veterinary*; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary*; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000601:surgery / Q000662:veterinary*; D014746:Vimentin / Q000032:analysis
D014746:Vimentin; D000469:Alkaline Phosphatase