Minced articular cartilage--basic science, surgical technique, and clinical application.
Minced articular cartilage procedures are attractive surgical approaches for repairing articular cartilage, as they are 1-staged, autologous, and inserted on a carrier that can potentially be placed arthroscopically. The principle of mincing the autologous donor cartilage is to create a larger surface area for cartilage expansion. Placement on a scaffold carrier allows for a chondro-inductive and chondro-conductive milieu. Early animal and preclinical models have demonstrated hyaline-like tissue repair. Further work needs to be conducted in this promising approach.
McCormick
Frank
F
Department of Orthopaedic Surgery, Naval Medical Center, San Diego, CA, USA. drfrankmccormick@yahoo.com
Yanke
Adam
A
Provencher
Matthew T
MT
Cole
Brian J
BJ
D000818:Animals; D001182:Arthroscopy / Q000379:methods*; D001672:Biocompatible Materials; D002357:Cartilage Diseases / Q000601:surgery*; D002358:Cartilage, Articular / Q000601:surgery / Q000637:transplantation*; D002417:Cattle; D019902:Chondrocytes / Q000637:transplantation; D002986:Clinical Trials as Topic; D005260:Female; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D008297:Male; D019060:Minimally Invasive Surgical Procedures; D011379:Prognosis; D012680:Sensitivity and Specificity; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds; D016378:Tissue Transplantation / Q000379:methods*; D014182:Transplantation, Autologous
D001672:Biocompatible Materials