[Allotransplantation of Leydig cells increases serum testosterone in rats].
OBJECTIVE
To observe the changes of serum testosterone after allotransplantation of Leydig cells in rats.


METHODS
Leydig cells were isolated from the testes of SD rats with the Percoll technique and serum testosterone of the receptors was determined once a month for 3 successive times.


RESULTS
After allotransplantation of Leydig cells, the serum testosterone level of the receptors increased gradually, significantly higher at 3 months than that of the normal rats younger than 2 months old.


CONCLUSIONS
Allotransplantation of Leydig cells has a promising application value in the treatment of male primary hypogonadism.
Sun
Jie
J
Department of Surgery, Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200127, China. ppdrsun@gmail.com
Shi
Cheng-Ren
CR
Xi
Ye-Bin
YB
Li
Wei-Yi
WY
Li
Huai-Yuan
HY
D000818:Animals; D017690:Cell Transplantation; D007985:Leydig Cells / Q000166:cytology / Q000637:transplantation*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013739:Testosterone / Q000097:blood*
D013739:Testosterone