In-vitro activity of tigecycline against clinical isolates of Acinetobacter baumannii in Taiwan.
We performed susceptibility testing using the microdilution method to determine the in-vitro activity of tigecycline against 393 Acinetobacter baumannii clinical isolates collected in 2006 from 19 hospitals in Taiwan. Significant proportions of the isolates were resistant to imipenem (44%), ciprofloxacin (75%), amikacin (69%), sulbactam (34%) and all four antibiotics (22%), and susceptibility to tigecycline among these different resistant phenotypes of A. baumannii varied from 71% to 82%. The minimum inhibitory concentration (MIC) of tigecycline ranged from 0.6 to 16 microg/mL (MIC(50) 2 microg/mL; MIC(90) 4 microg/mL). The cumulative curve of tigecycline MICs showed that when the MIC cut-offs were set at 2 microg/mL and 4 microg/mL, 80.9% and 93.1% of the isolates were susceptible, respectively. As tigecycline will be used in the future for infections caused by multidrug-resistant A. baumannii because of limited antibiotic choice, and as resistance to tigecycline in A. baumannii isolates may develop following antibiotic exposure, continuous monitoring of the susceptibility of A. baumannii isolates to tigecycline is warranted.
Liu
Jien-Wei
JW
Division of Infectious Diseases, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Wang
Lih-Shinn
LS
Cheng
Yu-Jen
YJ
Hsu
Gwo-Jong
GJ
Lu
Po-Liang
PL
Liu
Yung-Ching
YC
Chen
Chih-Ming
CM
Lee
Chun-Ming
CM
Sun
Wu
W
Jang
Tsrang-Neng
TN
Chiang
Ping-Cherng
PC
Chuang
Yin-Ching
YC
Lin
Hsiu-Chen
HC
Shi
Zhi-Yuan
ZY
Kung
Hsiang-Chi
HC
Huang
Cheng-Hua
CH
Tsao
Shih-Ming
SM
Lu
Chin-Te
CT
Liao
Chun-Hsing
CH
Hsueh
Po-Ren
PR
D000151:Acinetobacter Infections / Q000382:microbiology*; D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000302:isolation & purification*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology; D013624:Taiwan; D000078304:Tigecycline
D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D008911:Minocycline