MPTP- but not methamphetamine-induced parkinsonism extends to catecholamine neurons in the gut.
Methamphetamine (METH) produces nigrostriatal dopamine (DA) loss, partly resembling that which occurs in Parkinson's disease (PD). In PD there is also a marked alteration in the gut. Given the similarities between the central DA denervation produced by METH and PD, in the present study we evaluated the alterations in the gut following upon METH administration. To compare these effects with those occurring in PD, we also administered the parkinsonism-inducing neurotoxin MPTP. METH and MPTP were administered to mice, and after 7 days we investigated the immunostaining for tyrosine hydroxylase in nervous plexuses. These data indicate that METH did not alter the catecholamine-containing axons and autonomic neurons, while MPTP markedly reduced these components.
Natale
Gianfranco
G
Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy.
Kastsiuchenka
Olga
O
Pasquali
Livia
L
Ruggieri
Stefano
S
Paparelli
Antonio
A
Fornai
Francesco
F
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000009:adverse effects*; D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D015259:Dopamine Agents / Q000378:metabolism*; D041981:Gastrointestinal Tract / Q000166:cytology / Q000187:drug effects; D008297:Male; D008694:Methamphetamine / Q000633:toxicity*; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D009498:Neurotoxins / Q000378:metabolism; D010302:Parkinson Disease, Secondary / Q000139:chemically induced*; D011897:Random Allocation
D002395:Catecholamines; D015259:Dopamine Agents; D009498:Neurotoxins; D008694:Methamphetamine; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine