Unfaithful association of FCGR2B genetic polymorphisms with susceptibility to SLE.
Correcting errors and proofreading are crucial in a post-genomic era, when DNA sequences are already part of an effective medical screening and treatments. SNPs genotyping of complex human genes can lead to questionable associations if not properly handled. Here, we report about a spurious (reitered) association between FCGR2B genetic polymorphisms and systemic lupus erythematosus.
Napolioni
Valerio
V
Department of Biology MCA, University of Camerino, Camerino, Italy.
Barucca
Alessandra
A
Bolli
Elisabetta
E
Concetti
Antonio
A
Venanzi
Franco Maria
FM
D001483:Base Sequence; D002681:China / Q000453:epidemiology; D005190:Family; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology / Q000235:genetics*; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D017452:Receptors, IgG / Q000235:genetics*
C499173:FCGR2B protein, human; D017452:Receptors, IgG