Fatal pneumonitis induced by oxaliplatin.
Oxaliplatin has been approved for adjuvant treatment of colorectal cancer. Toxicity induced by oxaliplatin is moderate and manageable, but some isolated cases of severe pulmonary toxicity associated to oxaliplatin have been reported. Two fatal cases of interstitial pneumonitis rapidly evolving to pulmonary fibrosis are reported here.
Arévalo Lobera
Sara
S
Department of Medical Oncology, Hospital Donostia, Donostia, Guipúzcoa, Spain. sara.arevalo@osakidetza.net
Sagastibeltza Mariñelarena
Naiara
N
Elejoste Echeberría
Ibone
I
Melé Olivé
Mireia
M
Egaña Otaño
Larraitz
L
Basterretxea Badiola
Laura
L
La Casta Muñoa
Adelaida
A
Azkue Gabilondo
Mikel
M
D000230:Adenocarcinoma / Q000188:drug therapy / Q000556:secondary / Q000601:surgery; D000368:Aged; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D014890:Granulomatosis with Polyangiitis / Q000150:complications; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary / Q000601:surgery; D008297:Male; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D000077150:Oxaliplatin; D011013:Pneumonectomy; D011183:Postoperative Complications / Q000139:chemically induced; D011650:Pulmonary Alveoli / Q000473:pathology; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D012128:Respiratory Distress Syndrome / Q000209:etiology; D012811:Sigmoid Neoplasms / Q000601:surgery; D014057:Tomography, X-Ray Computed
D018906:Antineoplastic Agents, Alkylating; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D002955:Leucovorin; D005472:Fluorouracil