title: Pharmacokinetics and bioavailability of cefquinome in healthy piglets.
abstract: A study on bioavailability and pharmacokinetics of cefquinome in piglets was conducted after intravenous (i.v.) and intramuscular (i.m.) administrations of 2.0 mg/kg of body weight, respectively. Plasma concentrations were measured by high-performance liquid chromatography assay with UV detector at 268-nm wavelength. Plasma concentration-time data after i.v. administration were best fit by a two-compartment model. The pharmacokinetic values were distribution half-life 0.27 +/- 0.21 h, elimination half-life 1.85 +/- 1.11 h, total body clearance 0.26 +/- 0.08 L/kg.h, area under curve 8.07 +/- 1.91 microg x h/mL and volume of distribution at steady state 0.46 +/- 0.10 L/kg. Plasma concentration-time data after i.m. administration were also best fit by a two-compartment model. The pharmacokinetic parameters were distribution half-life 0.88 +/- 0.42 h, elimination half-life 4.36 +/- 2.35 h, peak concentration 4.01 +/- 0.57 microg/mL and bioavailability 95.13 +/- 9.93%.
authors.affiliation: Feed Research Institute of Chinese Academy of Agricultural Sciences, Beijing, China.
authors.forename: X B
authors.initials: XB
authors.lastname: Li
authors.forename: W X
authors.initials: WX
authors.lastname: Wu
authors.forename: D
authors.initials: D
authors.lastname: Su
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Wang
authors.forename: H Y
authors.initials: HY
authors.lastname: Jiang
authors.forename: J Z
authors.initials: JZ
authors.lastname: Shen
mesh_terms: D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D002511:Cephalosporins / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006207:Half-Life; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008297:Male; D008657:Metabolic Clearance Rate; D013552:Swine
chemical_list: D002511:Cephalosporins; C068212:cefquinome