Butyrylcholinesterase activity and mortality risk in hemodialysis patients: comparison to hsCRP and albumin.
OBJECTIVE
To test the prediction power of butyrylcholinesterase (BuChE) activity for mortality risk in hemodialysis patients during 12 months follow-up, and made comparison to hsCRP and albumin.


METHODS
The study enrolled 62 patients, aged 31-79 years. Serum BuChE, high-sensitivity C-reactive protein (hsCRP) and albumin were measured after 1, 3, 9 and 12 months of dialysis. The Kaplan-Meier survival curves were employed in mortality prediction.


RESULTS
BuChE was positively associated with serum albumin (r=0.318; p=0.012) and inversely related to hsCRP (r=-0.358; p=0.004). The highest mortality was in the lowest quartile of basal albumin (<38.4 g/L; p=0.027), hsCRP concentrations >8 mg/L (p=0.005), and BuChE activity in the lowest tercile of basal values (<5.92 kU/L; p=0.0041).


CONCLUSIONS
Our results suggest that low BuChE activity may be a nonspecific risk factor for mortality in patients who are on hemodialysis.
Stojanov
Marina D
MD
Institute of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, PO Box 146, 11000 Belgrade, Serbia. stmarina@EUnet.rs
Jovicić
Dusanka M
DM
Djurić
Stevan P
SP
Konjević
Marija M
MM
Todorović
Zoran M
ZM
Prostran
Milica S
MS
D000328:Adult; D000368:Aged; D002091:Butyrylcholinesterase / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012307:Risk Factors; D012709:Serum Albumin / Q000378:metabolism*
D012709:Serum Albumin; D002097:C-Reactive Protein; D002091:Butyrylcholinesterase