title: Correlation of cervical cytology and visual inspection with acetic acid in HIV-positive women.
abstract: The prevalence of squamous intraepithelial lesion is higher among human immunodeficiency virus (HIV)-positive women. These lesions when they occur in these patients are also more difficult to treat. A total of 205 consenting HIV-seropositive women were recruited. A cervical cytology (Pap smear) was taken, followed by visual inspection with freshly prepared 5% acetic acid and cervical biopsy taken from the squamocolumnar junction as the reference for diagnosis to avoid verification bias. The sensitivity of VIA was 76.0% (95% CI 52.0-91.0); specificity 83.0% (95% CI 77.0-88.0); positive predictive value 34.0% (95% CI 21.0-49.0). The sensitivity of cervical cytology (Pap smear) was 57.0% (95% CI 34.0-77.0), specificity of 95.0% (95% CI 90.0-97.0), and positive predictive value of 55.0% (95% CI 33.0-75.0). In HIV-seropositive women, the sensitivity of VIA is 76.0%, making it a useful screening test for preinvasive lesion of the cervix in low resource settings.
authors.affiliation: Department of Obstetrics and Gynaecology, University College Hospital, Ibadan, Nigeria. akinkan1@yahoo.com
authors.forename: A L
authors.initials: AL
authors.lastname: Akinwuntan
authors.forename: O A
authors.initials: OA
authors.lastname: Adesina
authors.forename: C A
authors.initials: CA
authors.lastname: Okolo
authors.forename: O A
authors.initials: OA
authors.lastname: Oluwasola
authors.forename: A
authors.initials: A
authors.lastname: Oladokun
authors.forename: A A
authors.initials: AA
authors.lastname: Ifemeje
authors.forename: I F
authors.initials: IF
authors.lastname: Adewole
mesh_terms: D019342:Acetic Acid; D000293:Adolescent; D000328:Adult; D002584:Cervix Uteri / Q000473:pathology; D015897:Comorbidity; D005260:Female; D006679:HIV Seropositivity / Q000453:epidemiology / Q000473:pathology*; D006801:Humans; D007202:Indicators and Reagents; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D065006:Papanicolaou Test; D010808:Physical Examination / Q000379:methods; D011230:Precancerous Conditions / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000453:epidemiology; D014626:Vaginal Smears; D055815:Young Adult
chemical_list: D007202:Indicators and Reagents; D019342:Acetic Acid