The possible role of proton pump inhibitors of the homeostasis of the inner ear.
The possibility of a benefit in some cases of inner ear sufferance by using proton pump inhibitors has been considered after a casual observation. The hypothesis is advanced considering the adverse effect of reflux on the eustachian tube function, the possible influence of the latter on inner ear symptoms and, from a more general point of view, the trigger effect which a gastric dysfunction requiring proton pump inhibitors could exert on the sympathetic system. These considerations, deserving a further study, seem to be based on logical assessment and therefore in our opinion deserve to be kept in mind in trying to define inner ear disorders of uncertain origin.
Pirodda
Antonio
A
Department of Specialistic Surgical and Anesthesiological Sciences, University of Bologna, via Massarenti n.9, 40138 Bologna, Italy.
Brandolini
Cristina
C
Raimondi
Maria Chiara
MC
Modugno
Giovanni Carlo
GC
D000818:Animals; D007758:Ear, Inner / Q000187:drug effects / Q000378:metabolism*; D006706:Homeostasis / Q000187:drug effects*; D006801:Humans; D007759:Labyrinth Diseases / Q000188:drug therapy* / Q000378:metabolism*; D008954:Models, Biological; D054328:Proton Pump Inhibitors / Q000008:administration & dosage*; D017494:Proton Pumps / Q000378:metabolism*
D054328:Proton Pump Inhibitors; D017494:Proton Pumps