title: Diarrhea, negative t-waves, fever and skin rash, rare manifestation of carbamazepine hypersensitivity: a case report.
abstract: BACKGROUND
  Antiepileptic drug induced hypersensitivity syndrome is a rare side effect of some of the first line anticonvulsive drugs such as carbamazepine and other aromatic agents. We are the first to mention a rare case of gastrointestinal, skin and cardiac findings related to carbamazepine administration, which is very uncommon and needs to be reported.
  
  
  METHODS
  We report on a 62-year-old Caucasian woman with carbamazepine associated hypersensitivity syndrome, who developed diarrhea, fever, skin lesions, pericardial effusion and pathology on electrocardiogram with terminal negative T waves in I, II, aVL, V5 and V6,. After withdrawal of carbamazepine and administration of methylprednisolone, all initial symptoms improved, white blood cell count normalized, pericardial effusion resolved and pathologic electrocardiogram findings resolved.
  
  
  CONCLUSIONS
  Anticonvulsive drug hypersensitivity syndromes can present with a wide spectrum of unspecific symptoms, which the prescribing clinician should be aware of.
authors.affiliation: Department of Surgery, University of Virginia health services, Charlottesville, VA, USA. HB3E@virginia.edu.
authors.forename: Felix
authors.initials: F
authors.lastname: Aigner
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Aigner
authors.forename: Friedrich
authors.initials: F
authors.lastname: Hoppichler
authors.forename: Gerhard
authors.initials: G
authors.lastname: Luef
authors.forename: Hugo
authors.initials: H
authors.lastname: Bonatti