title: [Alveolar ventilation and recruitment under lung protective ventilation].
abstract: Goal of mechanical ventilation is to improve gas exchange and reduce work of breathing without contributing to further lung injury. Besides providing adequate EELV and thereby arterial oxygenation PEEP in addition to a reduction in tidal volume is required to prevent cyclic alveolar collapse and tidal recruitment and hence protective mechanical ventilation. Currently, there is no consensus if and if yes at which price alveolar recruitment with high airway pressures should be intended ("open up the lung"), or if it is more important to reduce the mechanical stress and strain to the lungs as much as possible ("keep the lung closed"). Potential of alveolar recruitment differs from patient to patient but also between lung regions. Potential for recruitment depends probably more on regional lung mechanics - especially on lung elastance - than on the underlying disease. Based on available data neither high PEEP nor other methods used for alveolar recruitment could demonstrate a survival benefit in patients with ARDS. These results may support an individualized titration of PEEP or other manoeuvres used for recruitment taking into consideration the regional effects. Bedside imaging techniques allowing titration of PEEP or other manoeuvres to prevent end-expiratory alveolar collapse (tidal recruitment) and inspiratory overinflation may be a promising development.
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Bonn, Germany. Christian.Putensen@ukb.uni-bonn.de
authors.forename: Christian
authors.initials: C
authors.lastname: Putensen
authors.forename: Thomas
authors.initials: T
authors.lastname: Muders
authors.forename: Stefan
authors.initials: S
authors.lastname: Kreyer
authors.forename: Hermann
authors.initials: H
authors.lastname: Wrigge
mesh_terms: D001794:Blood Pressure; D045422:Continuous Positive Airway Pressure; D006801:Humans; D007385:Intermittent Positive-Pressure Ventilation; D055370:Lung Injury / Q000503:physiopathology / Q000517:prevention & control*; D008991:Monitoring, Physiologic; D011175:Positive-Pressure Respiration / Q000009:adverse effects / Q000379:methods; D012121:Respiration, Artificial / Q000009:adverse effects / Q000379:methods*; D012128:Respiratory Distress Syndrome / Q000503:physiopathology / Q000628:therapy*; D014057:Tomography, X-Ray Computed