title: Pentoxifylline and antioxidants improve sperm quality in male patients with varicocele.
abstract: We examined the effect of 12 weeks of daily oral administration of pentoxifylline with zinc and folic acid on the semen quality of 36 men with varicocele-associated infertility in an open, uncontrolled study. After 4 weeks of treatment, the proportion of morphologically normal sperm cells was significantly increased; these changes persisted until at least 4 weeks after the end of treatment.
authors.affiliation: Unidad de Andrologia, Servicio de Urologia, Hospital Italiano de Rosario, Rosario, Argentina.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Oliva
authors.forename: Alejandro
authors.initials: A
authors.lastname: Dotta
authors.forename: Luc
authors.initials: L
authors.lastname: Multigner
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005492:Folic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D010431:Pentoxifylline / Q000008:administration & dosage / Q000494:pharmacology*; D027724:Reproductive Techniques, Assisted; D013081:Sperm Motility / Q000187:drug effects* / Q000502:physiology; D013094:Spermatozoa / Q000187:drug effects* / Q000502:physiology; D014646:Varicocele / Q000188:drug therapy*
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D005492:Folic Acid; D010431:Pentoxifylline