title: An overview of viral and viral-like agents in cell culture systems.
abstract: The first recognition of seriously contaminated biological products occurred almost 100 years ago. More recently, in the second half of this century, the potential for contamination by viral and viral-like agents became obvious when the SV-40 virus was identified as an endogenous agent in the cell cultures used to produce polio vaccines. The history of major contamination incidents is reviewed, and current issues are discussed.
authors.affiliation: International Association of Biological Standardization, P.O.Box 1925, Palm Springs, CA, 92263-1925, U.S.A., jpmdpsca@aol.com.
authors.forename: J C
authors.initials: JC
authors.lastname: Petricciani