title: Fatal pneumonitis induced by oxaliplatin.
abstract: Oxaliplatin has been approved for adjuvant treatment of colorectal cancer. Toxicity induced by oxaliplatin is moderate and manageable, but some isolated cases of severe pulmonary toxicity associated to oxaliplatin have been reported. Two fatal cases of interstitial pneumonitis rapidly evolving to pulmonary fibrosis are reported here.
authors.affiliation: Department of Medical Oncology, Hospital Donostia, Donostia, Guipúzcoa, Spain. sara.arevalo@osakidetza.net
authors.forename: Sara
authors.initials: S
authors.lastname: Arévalo Lobera
authors.forename: Naiara
authors.initials: N
authors.lastname: Sagastibeltza Mariñelarena
authors.forename: Ibone
authors.initials: I
authors.lastname: Elejoste Echeberría
authors.forename: Mireia
authors.initials: M
authors.lastname: Melé Olivé
authors.forename: Larraitz
authors.initials: L
authors.lastname: Egaña Otaño
authors.forename: Laura
authors.initials: L
authors.lastname: Basterretxea Badiola
authors.forename: Adelaida
authors.initials: A
authors.lastname: La Casta Muñoa
authors.forename: Mikel
authors.initials: M
authors.lastname: Azkue Gabilondo
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000556:secondary / Q000601:surgery; D000368:Aged; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D014890:Granulomatosis with Polyangiitis / Q000150:complications; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary / Q000601:surgery; D008297:Male; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D000077150:Oxaliplatin; D011013:Pneumonectomy; D011183:Postoperative Complications / Q000139:chemically induced; D011650:Pulmonary Alveoli / Q000473:pathology; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D012128:Respiratory Distress Syndrome / Q000209:etiology; D012811:Sigmoid Neoplasms / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D018906:Antineoplastic Agents, Alkylating; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D002955:Leucovorin; D005472:Fluorouracil