title: Resveratrol regulates circadian clock genes in Rat-1 fibroblast cells.
abstract: Circadian clocks, especially peripheral clocks, can be strongly entrained by daily feedings, but few papers have reported the effects of food components on circadian rhythm. The effects of resveratrol, a natural polyphenol, on circadian clocks of Rat-1 cells were analyzed. A dose of 100 muM resveratrol, which did not show cytotoxicity, regulated the expression of clock genes Per1, Per2, and Bmal1.
authors.affiliation: National Food Research Institute (NFRI), National Agriculture and Food Research Organization (NARO), Tsukuba, Ibaraki, Japan. oike@affrc.go.jp
authors.forename: Hideaki
authors.initials: H
authors.lastname: Oike
authors.forename: Masuko
authors.initials: M
authors.lastname: Kobori
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002940:Circadian Rhythm / Q000187:drug effects* / Q000235:genetics*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D051381:Rats; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D013267:Stilbenes; D000077185:Resveratrol