Epigenetics in the nervous system.
It is becoming increasingly clear that epigenetic modifications are critical factors in the regulation of gene expression. With regard to the nervous system, epigenetic alterations play a role in a diverse set of processes and have been implicated in a variety of disorders. Gaining a more complete understanding of the essential components and underlying mechanisms involved in epigenetic regulation could lead to novel treatments for a number of neurological and psychiatric conditions.
Jiang
Yan
Y
Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA.
Langley
Brett
B
Lubin
Farah D
FD
Renthal
William
W
Wood
Marcelo A
MA
Yasui
Dag H
DH
Kumar
Arvind
A
Nestler
Eric J
EJ
Akbarian
Schahram
S
Beckel-Mitchener
Andrea C
AC
D000818:Animals; D001927:Brain Diseases / Q000235:genetics* / Q000378:metabolism* / Q000503:physiopathology; D002843:Chromatin / Q000235:genetics / Q000378:metabolism; D019175:DNA Methylation / Q000235:genetics; D044127:Epigenesis, Genetic / Q000235:genetics*; D005786:Gene Expression Regulation / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D056572:Histone Deacetylase Inhibitors; D006655:Histone Deacetylases / Q000378:metabolism; D006657:Histones / Q000235:genetics / Q000378:metabolism; D006801:Humans; D009420:Nervous System / Q000378:metabolism*
D002843:Chromatin; D056572:Histone Deacetylase Inhibitors; D006657:Histones; D006655:Histone Deacetylases