Association studies of the BDNF and the NTRK2 gene polymorphisms with prophylactic lithium response in bipolar patients.
The neuroplasticity hypothesis of bipolar disorder indicates that the BDNF/Trk signaling pathway is associated with the pathogenesis of this illness and treatment with mood stabilizers, such as lithium. This paper describes a relationship between response to lithium prophylaxis and polymorphisms of two functionally connected genes: BDNF and NTRK2, in bipolar illness. Analyses of four SNPs of the BDNF gene (rs2030324, rs988748, rs6265 [Val66Met]and rs2203877) and three of the NTRK2 gene (rs1187326, rs2289656, rs1187327) were performed in the 108 bipolar patients, classified as excellent responders (23%), partial responders (51%) and nonresponders (26%) to lithium. An association of C/G (rs988748) and G/A (rs6265) polymorphisms of the BDNF gene with a degree of prophylactic lithium response were found. No association with lithium response was revealed with the polymorphism of NTRK2 gene, neither with interaction of BDNF and NTRK2 genes.
Dmitrzak-Weglarz
Monika
M
Laboratory of Psychiatric Genetics, Department of Psychiatry, University of Medical Sciences, ul. Szpitalna 27/33, 60-572 Poznan, Poland. mweglarz@amp.edu.pl
Rybakowski
Janusz K
JK
Suwalska
Aleksandra
A
Skibinska
Maria
M
Leszczynska-Rodziewicz
Anna
A
Szczepankiewicz
Aleksandra
A
Hauser
Joanna
J
D000328:Adult; D000368:Aged; D018692:Antimanic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000235:genetics / Q000517:prevention & control*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D004247:DNA / Q000235:genetics; D004843:Epistasis, Genetic; D005260:Female; D006801:Humans; D016651:Lithium Carbonate / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D020813:Receptor, trkB / Q000235:genetics*; D012189:Retrospective Studies; D016896:Treatment Outcome
D018692:Antimanic Agents; D019208:Brain-Derived Neurotrophic Factor; D016651:Lithium Carbonate; D004247:DNA; D020813:Receptor, trkB