title: Calcitonin, sodium alendronate and high intensity laser in the treatment of traumatized teeth: a preliminary study.
abstract: The aim of this study was to evaluate the influence of erbium:yttrium-aluminum-garnet (Er:YAG) laser compared with traditional treatment on dentin permeability to calcitonin and sodium alendronate. Forty bovine roots were sectioned and divided into eight groups. Groups 1 and 2 (G1/G2) were immersed in saline solution; G1T/G2T were immersed in ethylene diamine tetra-acetic acid plus sodium lauryl ether sulfate (EDTA-T) and sodium hypochlorite (NaOCl); G1I/G2I were irradiated with Er:YAG laser (2.94 microm, 6 Hz, 40.4 J/cm(2)); G1TI/G2TI were immersed in EDTA-T, NaOCl and subjected to Er:YAG irradiation. After 4 h the radioactivity of the saline solution was measured. Statistical analysis revealed a significant difference (P < 0.05) when the groups treated with EDTA-T and NaOCl followed by Er:YAG laser irradiation were compared with the groups treated with EDTA-T only and with the groups that received no treatment. Er:YAG laser associated with traditional procedures significantly increased the diffusion of calcitonin and sodium alendronate through dentin. All groups showed calcitonin and sodium alendronate diffusion.
authors.affiliation: Department of Restorative Dentistry, School of Dentistry, University of São Paulo, São Paulo 05508-000, SP, Brazil. marinabello@usp.br
authors.forename: Marina Stella
authors.initials: MS
authors.lastname: Bello-Silva
authors.forename: José Luiz
authors.initials: JL
authors.lastname: Lage-Marques
authors.forename: Juliana
authors.initials: J
authors.lastname: Marotti
authors.forename: Carlos
authors.initials: C
authors.lastname: de Paula Eduardo
authors.forename: Christian
authors.initials: C
authors.lastname: Apel
authors.forename: Norbert
authors.initials: N
authors.lastname: Gutknecht
mesh_terms: D019386:Alendronate / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000818:Animals; D050071:Bone Density Conservation Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002116:Calcitonin / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002417:Cattle; D003804:Dentin / Q000378:metabolism; D066298:In Vitro Techniques; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D010539:Permeability; D018677:Tooth Injuries / Q000188:drug therapy* / Q000378:metabolism / Q000601:surgery*
chemical_list: D050071:Bone Density Conservation Agents; D002116:Calcitonin; D019386:Alendronate