Factors predictive of outcome in patients with de novo status epilepticus.
BACKGROUND
About 50% of status epilepticus (SE) patients have no previous history of epilepsy, but often have worse outcome. The aim of this study was to evaluate potential risk factors that are predictive of poor outcome in non-selected de novo status epilepticus patients.


METHODS
Eighty-three adult status epilepticus patients without a pre-existing history of epilepsy that were admitted to hospital for treatment were enrolled in this 11-year retrospective study. The baseline prognostic variables were analyzed based on stepwise logistic regression analysis after a minimum of one-and-half years of follow-up.


RESULTS
The overall fatality rate was 55.4% (46/83) during the study period. Poor outcome was associated with older age, presence of refractory status epilepticus, potential fatal etiologies, lower GCS score at presentation and level of consciousness on admission. The results of stepwise logistic regression demonstrated that age on presentation and potential fatal etiologies were independently associated with presence of poor outcome, and any increase in age by 1 year increases poor outcome by 7.5%.


CONCLUSIONS
The outcome for those with de novo status epilepticus is poor and this poor outcome may be attributed to the older age at onset and the potential fatal underlying conditions such as infection and metabolic derangement.
Tsai
M-H
MH
Department of Neurology, Chang Gung Memorial Hospital, #123 Ta Pei Road, Niao Sung Hsiang, Kaohsiung County, Taiwan.
Chuang
Y-C
YC
Chang
H-W
HW
Chang
W-N
WN
Lai
S-L
SL
Huang
C-R
CR
Tsai
N-W
NW
Wang
H-C
HC
Lin
Y-J
YJ
Lu
C-H
CH
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D023261:Glasgow Outcome Scale; D017052:Hospital Mortality; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D013226:Status Epilepticus / Q000175:diagnosis / Q000401:mortality*; D055815:Young Adult