Specialization of the general transcriptional machinery in male germ cells.
In adult animals, spermatogenesis involves a continuous differentiation of the spermatogonial stem and progenitor cell population into mature sperm. A unique aspect of this developmental process is the germ cell-specific expression and function of paralogues of components of the general transcription machinery, notably subunits of TFIID. Genetic and biochemical studies show that these paralogues play critical, but mechanistically distinct roles in Drosophila and mouse spermatogenesis.
Kolthur-Seetharam
Ullas
U
Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Illkirch, France.
Martianov
Igor
I
Davidson
Irwin
I
D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D008297:Male; D013091:Spermatogenesis / Q000235:genetics; D013094:Spermatozoa; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic
D014157:Transcription Factors