title: [Therapeutic effect of mitomycin C in the immediate postoperatory in patients with low-risk non-muscle-invasive bladder tumours].
abstract: BACKGROUND
  Bladder cancer is a disease with a high prevalence due to its recurrence rate. Transurethral resection of the bladder (TURB) is the treatment in initial stages. Nevertheless, a high percentage of non-muscle-invasive tumors treated will have a recurrence 1-2 years afterwards. Adjuvant quemotherapy or immunotherapy after TURB has been administered in order to decrease the rate of recurrence and to prevent progression.
  
  
  METHODS
  A prospectived, controlled and randomized study was performed. We included 100 patients with non-muscle-invasive and bladder tumors the low grade. All patients had initially a TURB performed and were randomized to either receive or not a single dose mitomycin C (MMC) in the immediate postoperatory.
  
  
  RESULTS
  All low grade tumors was less than 3 cm. Mean follow-up was 26.43 +/- 7.65 months. MMC was administered in 49 patients, of these, 67.3% had no recurrence and 32.7% had a non-muscle-invasive recurrence. Of the 51 patients in the non mitomycin, 51% had no recurrence while 47% had a non-muscle-invasive recurrence, and 2% had a muscle-invasive progression. We found significantly differences in time to recurrence among the two groups.
  
  
  CONCLUSIONS
  We found a greater time to recurrence in the group of single dose adjuvant MMC being this difference statistically significantly when comparing with the other group.
authors.affiliation: Servicio de Urología, Hospital Universitario Central de Asturias. ajalonm@hotmail.com
authors.forename: A
authors.initials: A
authors.lastname: Jalón Monzón
authors.forename: J M
authors.initials: JM
authors.lastname: Fernández Gómez
authors.forename: S
authors.initials: S
authors.lastname: Escaf Bramada
authors.forename: M
authors.initials: M
authors.lastname: Alvarez Múgica
authors.forename: J
authors.initials: J
authors.lastname: García Rodríguez
authors.forename: F J
authors.initials: FJ
authors.lastname: Regadera Sejas
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use*; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D011184:Postoperative Period; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000517:prevention & control* / Q000601:surgery*
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin