Production of the Auger emitter 119Sb for targeted radionuclide therapy using a small PET-cyclotron.
The use of Auger electrons in radionuclide therapy of cancer is a promising tool for specific tumor cell killing of micrometastases and small tumors. The radioisotope (119)Sb has recently been identified as a potent Auger-emitter for therapy. We here present a method for producing this isotope using a low-energy cyclotron. With this method, it will be possible to produce clinically relevant amounts of (119)Sb radioactivity with high chemical and radionuclidic purity for cancer therapy.
Thisgaard
H
H
The Hevesy Laboratory, Radiation Research Department, Risoe National Laboratory for Sustainable Energy, Technical University of Denmark, P.O. 49, DK-4000 Roskilde, Denmark.
Jensen
M
M
D000965:Antimony / Q000737:chemistry* / Q000627:therapeutic use; D017357:Cyclotrons; D009369:Neoplasms / Q000532:radiotherapy; D011868:Radioisotopes / Q000627:therapeutic use*; D014055:Tomography, Emission-Computed
D011868:Radioisotopes; D000965:Antimony