title: Severe sepsis in a premature neonate: protein C replacement therapy.
abstract: Treatment with activated protein C has been shown to reduce mortality in adult patients with severe sepsis but also to increase risk of bleeding. In patients with predisposition to bleeding, as in preterm infants, the inactivated form of protein C could serve as a safe therapeutic option. We report the case of a preterm neonate who developed severe sepsis on the 28th day of life, who was successfully treated with the inactivated form of protein C for a period of 96 hours.
authors.affiliation: Division of Neonatal Intensive Care, Department of Pediatrics, Catholic University of Sacred Heart, Rome, Italy.
authors.forename: Maria Pia
authors.initials: MP
authors.lastname: De Carolis
authors.forename: Valentina
authors.initials: V
authors.lastname: Polimeni
authors.forename: Patrizia
authors.initials: P
authors.lastname: Papacci
authors.forename: Serafina
authors.initials: S
authors.lastname: Lacerenza
authors.forename: Costantino
authors.initials: C
authors.lastname: Romagnoli
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D011486:Protein C / Q000008:administration & dosage / Q000627:therapeutic use*; D018805:Sepsis / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000925:Anticoagulants; D011486:Protein C