Pregnancy outcome after magnetic resonance-guided focused ultrasound surgery (MRgFUS) for conservative treatment of uterine fibroids.
OBJECTIVE
To report all pregnancies to date after magnetic resonance-guided focused ultrasound surgery (MRgFUS) for the conservative treatment of clinically significant uterine fibroids.


METHODS
Prospective registry of all known pregnancies occurring after MRgFUS maintained by the device manufacturer and reported to the Food and Drug Administration.


METHODS
World experience of pregnancies after treatment with reports from 13 sites in seven countries.


METHODS
Fifty-one reproductive-age women with uterine leiomyomas.


METHODS
Women underwent MRgFUS treatment for symptomatic uterine leiomyomas before this report.


METHODS
Pregnancy outcomes and complications.


RESULTS
Fifty-four pregnancies in 51 women have occurred after MRgFUS treatment of uterine leiomyomas. The mean time to conception was 8 months after treatment. Live births occurred in 41% of pregnancies, with a 28% spontaneous abortion rate, an 11% rate of elective pregnancy termination, and 11 (20%) ongoing pregnancies beyond 20 gestational weeks. The mean birth weight was 3.3 kg, and the vaginal delivery rate was 64%.


CONCLUSIONS
Preliminary pregnancy experience after MRgFUS is encouraging, with a high rate of delivered and ongoing pregnancies.
Rabinovici
Jaron
J
Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Israel.
David
Matthias
M
Fukunishi
Hidenobu
H
Morita
Yutaka
Y
Gostout
Bobbie S
BS
Stewart
Elizabeth A
EA
D000028:Abortion, Induced; D000022:Abortion, Spontaneous; D000328:Adult; D001724:Birth Weight; D005060:Europe; D005260:Female; D005298:Fertility; D005865:Gestational Age; D013509:Gynecologic Surgical Procedures; D006801:Humans; D007231:Infant, Newborn; D007557:Israel; D007564:Japan; D007889:Leiomyoma / Q000503:physiopathology / Q000601:surgery*; D018231:Leiomyomatosis / Q000503:physiopathology / Q000601:surgery*; D050498:Live Birth; D053783:Magnetic Resonance Imaging, Interventional; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures; D011247:Pregnancy; D011256:Pregnancy Outcome; D017697:Premenopause; D011446:Prospective Studies; D012042:Registries; D013997:Time Factors; D016896:Treatment Outcome; D014481:United States; D014594:Uterine Neoplasms / Q000503:physiopathology / Q000601:surgery*