title: Pediatric antibody response to community-acquired Staphylococcus aureus infection is directed to Panton-Valentine leukocidin.
abstract: We examined the antibody responses of pediatric patients infected with community-associated Staphylococcus aureus isolates. The data show that patients infected with Panton-Valentine leukocidin (PVL)-positive strains developed a dominant immunoglobulin G anti-PVL antibody response that correlates with markers of inflammation.
authors.affiliation: Center for Infectious Disease, University of Texas School of Public Health, 1200 Herman-Pressler Dr., Houston, TX 77030, USA. eric.l.brown@uth.tmc.edu
authors.forename: Eric L
authors.initials: EL
authors.lastname: Brown
authors.forename: M Gabriela
authors.initials: MG
authors.lastname: Bowden
authors.forename: Rebecca S
authors.initials: RS
authors.lastname: Bryson
authors.forename: Kristina G
authors.initials: KG
authors.lastname: Hulten
authors.forename: Andrea S
authors.initials: AS
authors.lastname: Bordt
authors.forename: Andrea
authors.initials: A
authors.lastname: Forbes
authors.forename: Sheldon L
authors.initials: SL
authors.lastname: Kaplan
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood*; D001427:Bacterial Toxins / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000276:immunology*; D005098:Exotoxins / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007956:Leukocidins / Q000276:immunology*; D013203:Staphylococcal Infections / Q000276:immunology*; D013211:Staphylococcus aureus / Q000276:immunology*; D037521:Virulence Factors / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D001427:Bacterial Toxins; D005098:Exotoxins; D007074:Immunoglobulin G; D007956:Leukocidins; C078284:Panton-Valentine leukocidin; D037521:Virulence Factors