A 6-aminoquinolone compound, WC5, with potent and selective anti-human cytomegalovirus activity.
We identified a 6-aminoquinolone compound, WC5, that inhibits human cytomegalovirus (HCMV) replication with a selectivity index of approximately 500. WC5 also showed activity against drug-resistant HCMV strains. In contrast, it did not significantly affect the replication of human herpesvirus 6 and 8 and was approximately 10-fold less active against murine cytomegalovirus. Thus, WC5 may represent a lead for the development of new, potent, and selective anti-HCMV compounds.
Mercorelli
Beatrice
B
Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Padua, Italy.
Muratore
Giulia
G
Sinigalia
Elisa
E
Tabarrini
Oriana
O
Biasolo
Maria Angela
MA
Cecchetti
Violetta
V
Palù
Giorgio
G
Loregian
Arianna
A
D000634:Aminoquinolines / Q000737:chemistry / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000187:drug effects* / Q000235:genetics*; D006801:Humans; D015394:Molecular Structure; D014779:Virus Replication / Q000187:drug effects
D000634:Aminoquinolines