Novel modulators for body weight changes induced by fasting and re-feeding in mice.
Catch-up weight gain after malnutrition is a risk factor for metabolic syndrome. Here we show that social isolation enhanced fasting-induced weight loss and suppressed weight gain induced by re-feeding for 6 days following a 24-h fast in prepubertal wild-type mice. These effects of social isolation on weight gain were not associated with significant changes in daily average food consumption. Under the same housing condition, genetic deletion of beta-endorphin reduced the fasting-induced weight loss and enhanced the re-feeding-induced weight gain in prepubertal mice. These effects of social isolation or genetic deletion of beta-endorphin on these weight changes were attenuated and reversed in postpubertal mice. Moreover, genetic deletion of beta-endorphin attenuated these effects of social isolation on the catch-up weight gain in prepubertal mice and reversed them in postpubertal mice. Thus, social isolation, endogenous beta-endorphin, and age can be novel modulators for body weight changes induced by fasting and re-feeding in mice.
Nonogaki
Katsunori
K
Center of Excellence, Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Japan.
Ohba
Yukie
Y
Sumii
Makiko
M
Wakameda
Mamoru
M
Tamari
Tomohiro
T
D000367:Age Factors; D000818:Animals; D005215:Fasting; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D012934:Social Isolation; D015431:Weight Loss; D001615:beta-Endorphin / Q000235:genetics / Q000378:metabolism*
D001615:beta-Endorphin