Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population.
Several lines of evidence from animal and genetic analyses showed that the calcineurin A gamma subunit gene (PPP3CC) plays an important role in the pathogenesis of schizophrenia. Moreover, a recent large Japanese case-control study confirmed the genetic association of PPP3CC with schizophrenia. The symptoms of methamphetamine (MAP)-induced psychosis are similar to those of schizophrenia, suggesting that PPP3CC is an attractive candidate gene not only for schizophrenia, but also for METH-related disorders. In this study, we carried out a genetic association study of PPP3CC with MAP-use disorder in a Japanese population. We selected five haplotype-tagging SNPs from the aforementioned replication study and genotyped 393 samples (MAP abuse, 128; control, 265). We could not detect a significant association of all tagging SNPs with each condition. In conclusion, our data suggest that PPP3CC does not elevate the risk of MAP-use disorder in the Japanese population.
Kinoshita
Y
Y
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan.
Ikeda
M
M
Ujike
H
H
Kitajima
T
T
Yamanouchi
Y
Y
Aleksic
B
B
Kishi
T
T
Kawashima
K
K
Ohkouchi
T
T
Ozaki
N
N
Inada
T
T
Harano
M
M
Komiyama
T
T
Hori
T
T
Yamada
M
M
Sekine
Y
Y
Iyo
M
M
Sora
I
I
Iwata
N
N
D019969:Amphetamine-Related Disorders / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D019703:Calcineurin / Q000235:genetics*; D016022:Case-Control Studies; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008694:Methamphetamine / Q000494:pharmacology*; D020641:Polymorphism, Single Nucleotide; D011605:Psychoses, Substance-Induced / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics
D000697:Central Nervous System Stimulants; D008694:Methamphetamine; D019703:Calcineurin; C525675:PPP3CC protein, human