title: Low cerebral blood flow velocity and head circumference in infants with severe hypoxic ischemic encephalopathy and poor outcome.
abstract: OBJECTIVE
  To evaluate long-term changes in cerebral blood flow velocity (CBFV) and head circumference in asphyxiated infants.
  
  
  METHODS
  CBFV was measured in 83 asphyxiated and 115 healthy term infants in anterior and middle cerebral, basilar and internal carotid artery (ICA) up to the age of 60-149 days. The psychomotor development and head circumference was followed for 18 months. RESULTS. Mean CBFV was increased (p < 0.05) during the first days after asphyxia in infants with severe hypoxic-ischemic encephalopathy (HIE) (n = 25) compared to control group or infants with mild to moderate HIE (n = 58) with maximum values found at the age of 36-71.9 h: in ICA (mean [95% CI]) 31.2 (25.5-36.6) cm/s in severe HIE infants compared to 13.0 (12.2-13.9) cm/s in controls. Decreased (p < 0.0001) mean CBFV developed in severe HIE infants by the age of 21-59 days: in ICA 14.1 (11.5-16.8) cm/s compared to 22.9 (21.4-24.4) cm/s in controls. Infants with severe HIE had similar mean height but lower head circumferences compared to controls (p < 0.05) at the age of 21-59 days.
  
  
  CONCLUSIONS
  The high mean CBFV found in infants with severe HIE during the first days after asphyxia is temporary and low CBFV and head circumference develops by the age of 21-59 days.
authors.affiliation: Radiology Service, Tartu University Hospital, Tartu, Estonia. pilvi.ilves@kliinikum.ee
authors.forename: Pilvi
authors.initials: P
authors.lastname: Ilves
authors.forename: Mare
authors.initials: M
authors.lastname: Lintrop
authors.forename: Inga
authors.initials: I
authors.lastname: Talvik
authors.forename: Külli
authors.initials: K
authors.lastname: Muug
authors.forename: Lea
authors.initials: L
authors.lastname: Maipuu
authors.forename: Tuuli
authors.initials: T
authors.lastname: Metsvaht
mesh_terms: D001238:Asphyxia Neonatorum / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001783:Blood Flow Velocity; D016022:Case-Control Studies; D002508:Cephalometry; D002536:Cerebral Arteries / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology; D007231:Infant, Newborn; D008297:Male; D011446:Prospective Studies; D014463:Ultrasonography