title: 2,6,9-Trisubstituted purine derivatives as protein A mimetics for the treatment of autoimmune diseases.
abstract: A series of 9-substituted and 2,9-disubstituted 6-(3-aminophenylamino) purines were synthesized and evaluated for their ability to mimic protein A binding to human IgG antibody. The structure-activity relationship (SAR) demonstrates that the 6-(3-aminoanilinyl) purine component was essential for activity. Purine 14 demonstrated significant activity, compared to protein A. These compounds may prove useful for the treatment of autoimmune diseases.
authors.affiliation: ProMetic BioSciences Inc, Que, Canada. b.zacharie@prometic.com
authors.forename: Boulos
authors.initials: B
authors.lastname: Zacharie
authors.forename: Daniel
authors.initials: D
authors.lastname: Fortin
authors.forename: Nicole
authors.initials: N
authors.lastname: Wilb
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Bienvenu
authors.forename: Michel
authors.initials: M
authors.lastname: Asselin
authors.forename: Brigitte
authors.initials: B
authors.lastname: Grouix
authors.forename: Christopher
authors.initials: C
authors.lastname: Penney
mesh_terms: D001327:Autoimmune Diseases / Q000188:drug therapy*; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D018716:Molecular Mimicry; D011687:Purines / Q000138:chemical synthesis* / Q000276:immunology* / Q000627:therapeutic use; D013205:Staphylococcal Protein A / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D007074:Immunoglobulin G; D011687:Purines; D013205:Staphylococcal Protein A