title: Emerging concepts in acute kidney injury following cardiac surgery.
abstract: Acute kidney injury (AKI) remains a significant cause of morbidity and mortality following cardiac surgery. Through a more thorough understanding of perioperative genomics and the evolving role of early biomarkers of AKI, the authors seek to improve meaningful outcomes among cardiac surgery patients. In this review, the focus will be on advances in risk stratification, evolving definitions and improving early diagnosis of AKI, identification of effective individualized therapies, and future directions.
authors.affiliation: Department of Anesthesiology Duke University Medical Center, Durham, North Carolina 27710, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Hudson
authors.forename: Jordan
authors.initials: J
authors.lastname: Hudson
authors.forename: Madhav
authors.initials: M
authors.lastname: Swaminathan
authors.forename: Andrew
authors.initials: A
authors.lastname: Shaw
authors.forename: Mark
authors.initials: M
authors.lastname: Stafford-Smith
authors.forename: Uptal D
authors.initials: UD
authors.lastname: Patel
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D000209:Acute-Phase Proteins / Q000652:urine; D015415:Biomarkers / Q000097:blood / Q000652:urine; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D055316:Cystatin C / Q000097:blood / Q000652:urine; D000072596:Hepatitis A Virus Cellular Receptor 1; D006801:Humans; D020382:Interleukin-18 / Q000652:urine; D000071068:Lipocalin-2; D054834:Lipocalins / Q000097:blood / Q000652:urine; D008562:Membrane Glycoproteins / Q000652:urine; D011518:Proto-Oncogene Proteins / Q000097:blood / Q000652:urine; D011991:Receptors, Virus; D018570:Risk Assessment / Q000379:methods; D009626:Terminology as Topic
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; D055316:Cystatin C; C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; D020382:Interleukin-18; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D008562:Membrane Glycoproteins; D011518:Proto-Oncogene Proteins; D011991:Receptors, Virus