Flexible total synthesis of biphenomycin B.
A total synthesis of the biaryl antibiotic biphenomycin B is reported which makes use of three independent building blocks (key steps were a clean Suzuki-Miyaura coupling of a free acid iodide, a novel 4-hydroxyornithine synthesis, and a high-yielding macrolactamization); a practical deprotection protocol allowed isolation of the target compound with excellent recovery and purity.
Waldmann
Herbert
H
Technische Universität Dortmund, Fakultät Chemie, Otto-Hahn-Str. 6, D-44227, Dortmund, Germany.
He
Yu-Peng
YP
Tan
Hao
H
Arve
Lars
L
Arndt
Hans-Dieter
HD
D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D010456:Peptides, Cyclic; C047537:biphenomycin B