[Cytotoxicity of the secondary metabolites of Marine Mangrove Fungus Paecilomyces sp. tree 1-7 on human hepatoma cell line HepG2].
OBJECTIVE
To study the cytotoxicity of the secondary metabolites of Marine Mangrove Fungus Paecilomyces sp. Tree 1-7 on human hepatoma cell line HepG2 cultured in vitro.


METHODS
Three groups were divided: compounds group, 5-Fu group and control group. The cytotoxicity was measured by MTT method when HepG2 cells were treated by different concentration of the secondary metabolites of Paecilomyces sp. Tree 1-7.


RESULTS
Secalonic acid A, tenellic acid A and alternin inhibited the growth of human hepatoma cell line HepG2, the IC50 separately were 2.0, 62.1 and 7.0 microg/ml.


CONCLUSIONS
Secalonic acid A and alternin have strong cytotoxicity on HepG2 cultured in vitro.
Cai
Xiao-Ling
XL
School of Chemical and Chemical Engineering,Sun Yat-sen University, Guangzhou 510275, China.
Gao
Jun-Ping
JP
Li
Qing
Q
Wen
Lu
L
She
Zhi-Gang
ZG
Lin
Yong-Cheng
YC
D000970:Antineoplastic Agents / Q000494:pharmacology*; D001565:Benzoates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular / Q000473:pathology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005472:Fluorouracil / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D008113:Liver Neoplasms / Q000473:pathology; D010143:Paecilomyces / Q000737:chemistry* / Q000378:metabolism; D010647:Phenyl Ethers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D043982:Rhizophoraceae / Q000382:microbiology*; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000970:Antineoplastic Agents; D001565:Benzoates; D010647:Phenyl Ethers; D044004:Xanthones; C540396:methyl 3-(1-acetoxy-3-methylbutyl)-2-methoxy-6-(2- methoxy-4-methyl-6-(2-oxopropyl)phenoxy)benzoate; C009218:secalonic acid; D005472:Fluorouracil