[Team-based medical care can improve tailor made chemotherapy for colorectal cancer].
We report that team-based medical care has an important role in tailor made chemotherapy for colorectal cancer. We organized a chemotherapy support team to facilitate the early detection of toxicity and to get hold of therapeutic needs in individual patients. We also measured the circadian variation of 5-fluorouracil plasma concentrations to permit tailor dosed chemotherapy. To date, the chemotherapy support team has managed the performance of pharmacokinetic modulating chemotherapy in 30 patients with unresectable or recurrent colorectal cancer. The median survival time was 19 months after the first-line chemotherapy and 14 months after the second-line treatment. Our results suggest that team-based medical care is practically useful for tailor made chemotherapy in patients with colorectal cancer.
Muneoka
Katsuki
K
Dept. of Surgery, Niitsu Medical Center Hospital.
Shirai
Yoshio
Y
Sasaki
Masataka
M
Kanda
Junkichi
J
Asakura
Toshinari
T
Wakabayashi
Hiroyuki
H
Toshima
Muneatsu
M
Hatakeyama
Katsuyoshi
K
D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000523:psychology; D004334:Drug Administration Schedule; D005260:Female; D005502:Food; D006801:Humans; D008297:Male; D008875:Middle Aged; D005791:Patient Care; D011795:Surveys and Questionnaires
D000970:Antineoplastic Agents