title: Quinpramine is a novel compound effective in ameliorating brain autoimmune disease.
abstract: Acridine-iminodibenzyl chimeric compounds were previously introduced as a class of cholesterol-redistributing substances with antiprion effects. Here, we show that administration of the lead compound quinpramine to mice with experimental autoimmune encephalitis, an animal model of multiple sclerosis (MS), significantly ameliorates disease in preventive and therapeutic paradigms. Quinpramine treatment decreased the number of inflammatory CNS lesions, antigen-specific T-cell proliferation, and pro-inflammatory cytokines IFNgamma and IL-17. Quinpramine is thus an immunoregulatory drug that is a candidate pharmaceutical for MS.
authors.affiliation: Department of Neurology, University of Texas Southwestern, Dallas, USA.
authors.forename: Mahendra P
authors.initials: MP
authors.lastname: Singh
authors.forename: Gerd
authors.initials: G
authors.lastname: Meyer zu Hörste
authors.forename: Wei
authors.initials: W
authors.lastname: Hu
authors.forename: Anne K
authors.initials: AK
authors.lastname: Mausberg
authors.forename: Petra D
authors.initials: PD
authors.lastname: Cravens
authors.forename: Todd
authors.initials: T
authors.lastname: Eagar
authors.forename: Stefan
authors.initials: S
authors.lastname: Löber
authors.forename: Ralf
authors.initials: R
authors.lastname: Klingenstein
authors.forename: Peter
authors.initials: P
authors.lastname: Gmeiner
authors.forename: Carsten
authors.initials: C
authors.lastname: Korth
authors.forename: Bernd C
authors.initials: BC
authors.lastname: Kieseier
authors.forename: Olaf
authors.initials: O
authors.lastname: Stüve
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D006023:Glycoproteins; D051379:Mice; D008810:Mice, Inbred C57BL; D063308:Myelin-Oligodendrocyte Glycoprotein; D010446:Peptide Fragments; D011806:Quinolinium Compounds / Q000627:therapeutic use*; D013601:T-Lymphocytes / Q000187:drug effects
chemical_list: D016207:Cytokines; D006023:Glycoproteins; D063308:Myelin-Oligodendrocyte Glycoprotein; D010446:Peptide Fragments; D011806:Quinolinium Compounds; C445081:myelin oligodendrocyte glycoprotein (35-55)