title: Impact of diabetes and acute coronary syndrome on survival in patients treated with drug-eluting stents.
abstract: BACKGROUND
  Diabetics who undergo percutaneous coronary intervention (PCI) are at increased risk for death, myocardial infarction, repeat revascularization, and stent thrombosis.
  
  
  METHODS
  Our retrospective study includes 887 consecutive patients who underwent PCI with drug-eluting stents (DES) at UCLA Medical Center. The cohort was divided into four groups: group 1, no diabetes and no acute coronary syndrome (ACS); group 2, no diabetes and ACS; group 3, diabetes and no ACS; group 4, diabetes and ACS.
  
  
  RESULTS
  Survival at 1 year was the lowest in diabetics who presented with ACS (90% in diabetics with ACS, 95% in diabetics without ACS, 95% in non-diabetics with ACS, and 96% in the non-diabetics without ACS, P = 0.03). At 1 year, age, diabetes, chronic renal insufficiency, ejection fraction, and myocardial infarction were identified as independent predictors for mortality.
  
  
  CONCLUSIONS
  In the DES era, diabetics who undergo PCI for ACS continue to have an excess risk of death and major adverse cardiac events at 1 year.
authors.affiliation: Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA. mslee@mednet.ucla.edu
authors.forename: Michael S
authors.initials: MS
authors.lastname: Lee
authors.forename: Daniel
authors.initials: D
authors.lastname: Jurewitz
authors.forename: Raymond
authors.initials: R
authors.lastname: Zimmer
authors.forename: Antonio
authors.initials: A
authors.lastname: Pessegueiro
authors.forename: Ravi
authors.initials: R
authors.lastname: Bhatia
authors.forename: Jesse
authors.initials: J
authors.lastname: Currier
authors.forename: Larry
authors.initials: L
authors.lastname: Yeatman
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Tobis
mesh_terms: D054058:Acute Coronary Syndrome / Q000000981:diagnostic imaging / Q000209:etiology / Q000401:mortality* / Q000628:therapy*; D000367:Age Factors; D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects / Q000295:instrumentation / Q000401:mortality; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000401:mortality* / Q000628:therapy*; D003920:Diabetes Mellitus / Q000401:mortality*; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology / Q000401:mortality; D016016:Proportional Hazards Models; D012042:Registries; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000401:mortality; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013318:Stroke Volume; D013997:Time Factors; D016896:Treatment Outcome