title: Cytotoxic prenylated xanthones from Calophyllum inophyllum.
abstract: A new prenylated xanthone (1), named caloxanthone N, together with two known constituents, gerontoxanthone C (2) and 2-hydroxyxanthone (3), was isolated from the ethanolic extract of the twigs of Calophyllum inophyllum. Their structures were completely elucidated using a combination of 1D, 2D NMR techniques (COSY, HMQC, HMBC, and ROESY) and HR-ESI-MS analyses. Compounds 1 and 2 exhibited cytotoxicity against chronic myelogenous leukemia cell line (K562) with IC50 values of 7.2 and 6.3 microg ml(- 1), respectively.
authors.affiliation: Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Xiao
authors.forename: Yan-Bo
authors.initials: YB
authors.lastname: Zeng
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Mei
authors.forename: You-Xing
authors.initials: YX
authors.lastname: Zhao
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Deng
authors.forename: Hao-Fu
authors.initials: HF
authors.lastname: Dai
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D029759:Calophyllum / Q000737:chemistry*; D015394:Molecular Structure; D044004:Xanthones / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D044004:Xanthones