Dietary marine-derived tocopherol has a higher biological availability in mice relative to alpha-tocopherol.
The biologic availability of two kinds of tocomonoenols, marine-derived tocopherol (MDT) and alpha-tocomonoenol, was investigated in ICR mice. Vitamin E-deficient ICR mice were fed MDT and alpha-tocomonoenol together with alpha-tocopherol, beta-tocopherol, gamma-tocopherol, and delta-tocopherol, and storage in liver, spleen, lung, and brain was quantified using reverse-phase high-performance liquid chromatography. The vitamin E relative biologic availability (VE-RBA) in liver was 100 for alpha-tocopherol, 26 +/- 3 for beta-tocopherol, 4 +/- 2 for gamma-tocopherol, not detected for delta-tocopherol, 49 +/- 6 for MDT, and 30 +/- 7 for alpha-tocomonoenol. The VE-RBA in brain was 100 for alpha-tocopherol, 5 +/- 2 for beta-tocopherol, not detected for gamma-tocopherol and delta-tocopherol, 8 +/- 1 for MDT, and 4 +/- 1 for alpha-tocomonoenol. Tocopherols and tocomonoenols did not accumulate in the spleen or lung. MDT and alpha-tocomonoenol had high VE-RBA values. The VE-RBA value for MDT was much higher than that for beta-tocopherol.
Gotoh
Naohiro
N
Department of Food Science and Technology, Tokyo University of Marine Science and Technology, 4-5-7 Konan, Minato-ku, Tokyo 108-8477, Japan.
Watanabe
Hiroyuki
H
Oka
Tomiko
T
Mashimo
Daisuke
D
Noguchi
Noriko
N
Hata
Kazuhiko
K
Wada
Shun
S
D000818:Animals; D001682:Biological Availability; D001923:Brain Chemistry; D004032:Diet; D005395:Fish Oils / Q000737:chemistry; D008099:Liver / Q000737:chemistry; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D019906:Nuclear Magnetic Resonance, Biomolecular; D024505:Tocopherols / Q000493:pharmacokinetics*; D014413:Tuna; D014810:Vitamin E / Q000031:analogs & derivatives / Q000378:metabolism; D014811:Vitamin E Deficiency / Q000378:metabolism; D024502:alpha-Tocopherol / Q000493:pharmacokinetics*
D005395:Fish Oils; C404388:alpha-tocomonoenol; D014810:Vitamin E; D024502:alpha-Tocopherol; D024505:Tocopherols