title: Autophagy connects antigen receptor signaling to costimulatory signaling in B lymphocytes.
abstract: In primary B lymphocytes (B cells), antigen stimulation induces transmembrane signaling through the B cell antigen receptor (BCR) that induces apoptosis. Activation of antigen-stimulated B cells requires additional signals termed costimulatory signals such as CD40L and TLR ligands that rescue B cells from apoptosis and induce their activation and proliferation. BCR signaling rapidly induces extensive autophagosome formation in B cells. Lines of evidence suggest that, in B cells as well as other cell types such as dendritic cells, autophagosomes play a role in efficient antigen presentation, a process in which antigenic peptides are expressed on the cell surface in a form complexed with major histocompatibility complex (MHC) molecules for recognition by T cells. Because antigen presentation of B cells is crucial for interaction with CD40L-expressing T helper cells, autophagy plays a role in connecting BCR signaling to costimulatory signaling through CD40. Recently, BCR ligation was demonstrated to translocate TLR9, a costimulatory receptor for pathogen-derived nucleic acids, to autophagosomes where TLR9 appears to interact with its ligands. Based on these findings we propose that autophagy plays a key role in connecting BCR signaling to costimulatory signaling.
authors.affiliation: Laboratory of Immunology, School of Biomedical Science, and Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Kozo
authors.initials: K
authors.lastname: Watanabe
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tsubata
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D001343:Autophagy; D001402:B-Lymphocytes / Q000166:cytology* / Q000276:immunology*; D018448:Models, Immunological; D011947:Receptors, Antigen, B-Cell / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*
chemical_list: D011947:Receptors, Antigen, B-Cell