Flavanones from the stem bark of Erythrina abyssinica.
Twelve new flavanones bearing a 2,2-dimethylpyrano ring were isolated from a MeOH extract of the stem bark of Erythrina abyssinica. Their structures were determined on the basis of spectroscopic (UV, CD, 1D and 2D NMR, HRMS) and physico-chemical analyses. Compounds 1, 3, 5, 6, 8, and 9 exhibited inhibitory effects on the enzyme activity of PTP1B in an in vitro assay with IC(50) values ranging from 13.9+/-2.1 to 19.0+/-1.8 microM. These results suggest that prenyl and methoxy groups on the B ring contribute to the inhibitory activity of flavanones against PTP1B.
Cui
Long
L
Korea Research Institute of Bioscience and Biotechnology (KRIBB), 52 Eoun-dong, Yuseong-gu, Daejeon 305-806, Republic of Korea.
Thuong
Phuong Thien
PT
Lee
Hyun Sun
HS
Ndinteh
Derek Tantoh
DT
Mbafor
Joseph Tanyi
JT
Fomum
Zacharias Tanee
ZT
Oh
Won Keun
WK
D004895:Erythrina / Q000737:chemistry*; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D024301:Plant Bark / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors
D044950:Flavanones; C516607:PTPN1 protein, human; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1