Transcriptional regulation of peptidylarginine deiminase expression in human keratinocytes.
Peptidylarginine deiminase (PAD, EC 3.5.3.15) enzyme catalyzes the conversion of arginine residues to citrulline residues in the presence of calcium ion, which is an elaborate post-translational modification on the target protein. Recently, five isoforms have been identified in mammals. Among them, three isoforms (type I, II, III) are expressed in the human epidermis, and involved in several skin physiological and pathological processes. In the past few years, several researches concerning the transcriptional regulation of three human PADI type genes (PADI1, PADI2 and PADI3) in the epidermis have been carried out. In this review, we describe an overview of the current outcomes about these studies with their significance. It is anticipated that these investigations will provide novel therapeutic and prophylactic targets for future approaches to the treatment or prevention of severe psoriasis and bullous congenital ichthyosiform erythroderma.
Ying
Shibo
S
Department of Applied Biological Resource Sciences, School of Agriculture, Ibaraki University, Inashiki-gun, Ibaraki, Japan.
Dong
Sijun
S
Kawada
Akira
A
Kojima
Toshio
T
Chavanas
Stéphane
S
Méchin
Marie-Claire
MC
Adoue
Véronique
V
Serre
Guy
G
Simon
Michel
M
Takahara
Hidenari
H
D001483:Base Sequence; D006706:Homeostasis / Q000235:genetics; D006801:Humans; D006867:Hydrolases / Q000235:genetics* / Q000378:metabolism*; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D015603:Keratinocytes / Q000166:cytology / Q000378:metabolism*; D008969:Molecular Sequence Data; D000080064:Protein-Arginine Deiminase Type 2; D000076342:Protein-Arginine Deiminases; D012879:Skin Physiological Phenomena / Q000235:genetics; D014158:Transcription, Genetic / Q000502:physiology*
D007527:Isoenzymes; D006867:Hydrolases; C000620352:PADI2 protein, human; D000080064:Protein-Arginine Deiminase Type 2; D000076342:Protein-Arginine Deiminases