Association between interleukin 1 polymorphisms and rheumatoid arthritis susceptibility: a metaanalysis.
OBJECTIVE
To determine whether interleukin 1 (IL-1) polymorphisms confer susceptibility to rheumatoid arthritis (RA).


METHODS
We conducted metaanalyses on associations between IL-1 polymorphisms and RA susceptibility, using fixed or random effects models.


RESULTS
A total of 18 separate comparisons were made using 10 European, 7 Asian, and 1 Latin American population samples. Metaanalysis of the IL-1B+3954 CC genotype revealed an association with RA in all subjects (odds ratio=0.776, 95% confidence interval=0.609-0.988, p=0.040). In Asians, an association between IL-1B+3954 and RA was identified. In contrast, no association was found between the IL-1B+3954 polymorphism and RA susceptibility in European populations. Metaanalyses of the IL-1B-511 and IL-1RN VNTR polymorphisms identified no association between these polymorphisms and RA.


CONCLUSIONS
Our metaanalysis shows that the IL-1B+3954 polymorphism was associated with the development of RA, but only in Asians.
Lee
Young Ho
YH
Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1 ga, Anam-dong, Seongbuk-gu, Seoul, 136-705, Korea. lyhcgh@korea.ac.kr
Ji
Jong Dae
JD
Song
Gwan Gyu
GG
D001172:Arthritis, Rheumatoid / Q000208:ethnology* / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000208:ethnology; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
D007375:Interleukin-1