title: Primary lymphoma of bone: an institutional experience.
abstract: A retrospective analysis of factors influencing survival in patients with primary lymphoma of bone (PLB) treated at a single institution was performed. The records of 30 eligible patients were evaluated for overall survival (OS) as related to age, sex, stage, International Prognostic Index (IPI) score, number of sites involved and type of treatment. There was a significant difference in OS in patients with IPI scores of low (L) and low intermediate (LI) versus high intermediate (HI) (P = 0.0035), regardless of stage. Sex, age, stage and number of sites did not have a significant influence on OS. There was a statistically significant difference in OS favouring use of combined chemotherapy (with or without rituximab) and radiation compared with either modality alone (P = 0.02). The addition of rituximab resulted in a non-significant trend towards improved OS (P = 0.11). With a median follow up of 49 months, 73% of patients are alive 5 years from diagnosis.
authors.affiliation: Section of Hematology/Oncology, Washington Hospital Center, Washington, DC, USA. joseph.p.catlett@medstar.net
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Catlett
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Williams
authors.forename: Shannon C
authors.initials: SC
authors.lastname: O'Connor
authors.forename: Jayashree
authors.initials: J
authors.lastname: Krishnan
authors.forename: Vera
authors.initials: V
authors.lastname: Malkovska
mesh_terms: D000367:Age Factors; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012720:Severity of Illness Index; D012737:Sex Factors; D016019:Survival Analysis