title: Divergence in cis-regulatory networks: taking the 'species' out of cross-species analysis.
abstract: Many essential transcription factors have conserved roles in regulating biological programs, yet their genomic occupancy can diverge significantly. A new study demonstrates that such variations are primarily due to cis-regulatory sequences, rather than differences between the regulators or nuclear environments.
authors.affiliation: European Molecular Biology Laboratory, D-69117 Heidelberg, Germany.
authors.forename: Robert P
authors.initials: RP
authors.lastname: Zinzen
authors.forename: Eileen E M
authors.initials: EE
authors.lastname: Furlong
mesh_terms: D000818:Animals; D012321:DNA-Directed RNA Polymerases; D019143:Evolution, Molecular; D053263:Gene Regulatory Networks; D006801:Humans; D013045:Species Specificity; D014157:Transcription Factors / Q000235:genetics*; D014158:Transcription, Genetic
chemical_list: D014157:Transcription Factors; D012321:DNA-Directed RNA Polymerases