Unusual paraneoplastic syndromes of breast carcinoma: a combination of cerebellar degeneration and Lambert-Eaton Myasthenic Syndrome.
BACKGROUND
Paraneoplastic neurological disorders are rare complications of breast carcinoma. Lambert-Eaton Myasthenic Syndrome (LEMS) is most commonly associated with small cell lung cancer. However, a combination of LEMS and subacute cerebellar degeneration as paraneoplastic syndromes is extremely rare, and has never been described in association with breast cancer.


METHODS
We report for the first time an unusual association of LEMS and paraneoplastic subacute cerebellar degeneration with breast carcinoma.


CONCLUSIONS
In patients with atypical LEMS, when there is no evidence of respiratory malignancy, breast cancer should be included in the differential diagnosis.
Romics
L
L
Department of Surgery, Cork University Hospital, Wilton, Cork, Ireland. Laszlo.Romics@umassmed.edu
McNamara
B
B
Cronin
P A
PA
O'Brien
M E
ME
Relihan
N
N
Redmond
H P
HP
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D005260:Female; D006801:Humans; D015624:Lambert-Eaton Myasthenic Syndrome / Q000150:complications*; D008875:Middle Aged; D020362:Paraneoplastic Cerebellar Degeneration / Q000150:complications*