Antimicrobial activities of 3-amino- and polyaminosterol analogues of squalamine and trodusquemine.
A series of 3-amino- and polyaminosterol analogues of squalamine and trodusquemine were synthesized and evaluated for their in vitro antimicrobial properties against human pathogens. The activity was highly dependent on the structure of the different compounds involved and the best results were obtained with aminosterol derivatives 4b, 4e, 8b, 8e and 8n exhibiting minimum inhibitory concentrations (MICs) against yeasts, Gram positive and Gram negative bacteria at average concentrations of 3.12-12.5 microM.
Salmi
Chanaz
C
Laboratoire SESNAB, UMR-MD1, case 342, Faculté de St Jérome, Université de Méditerranée, Marseille, Cedex 20, France.
Loncle
Celine
C
Vidal
Nicolas
N
Laget
Michéle
M
Letourneux
Yves
Y
Brunel
Jean Michel
JM
D000588:Amines / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002776:Cholestanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002777:Cholestanols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D050296:Microbial Viability / Q000187:drug effects; D015394:Molecular Structure; D013096:Spermine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013261:Sterols / Q000737:chemistry*; D013329:Structure-Activity Relationship
C441128:3-N-1(spermine)-7, 24-dihydroxy-5-cholestane 24-sulfate; D000588:Amines; D000900:Anti-Bacterial Agents; D002776:Cholestanes; D002777:Cholestanols; D013261:Sterols; D013096:Spermine; C079655:squalamine