title: Foreword: "The Big Three".
authors.affiliation: University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Stephen I
authors.initials: SI
authors.lastname: Rennard
authors.forename: Tim
authors.initials: T
authors.lastname: Higenbottam
authors.forename: Alan R
authors.initials: AR
authors.lastname: Leff
mesh_terms: D003226:Congresses as Topic; D006331:Heart Diseases; D006801:Humans; D008175:Lung Neoplasms; D029424:Pulmonary Disease, Chronic Obstructive