title: [Remarkable effect of gemcitabine-oxaliplatin (GEMOX) therapy in a patient with advanced metastatic mucinous cystic neoplasm of the pancreas].
abstract: Gemcitabine(GEM)is the standard therapy for advanced pancreatic cancer. GEM-oxaliplatin (GEMOX) combination treatment has been reported to be superior to GEM alone in terms of clinical progression-free survival, but it is not the therapy of choice for pancreatic cancer. We report a case of advanced mucinous cystic neoplasm (MCN) of the pancreas with multiple hepatic metastases in a 39-year-old female. She was treated with 16 courses of GEMOX (GEM 1,500 mg/day at a rate of 10 mg/m2/min on the first day and oxaliplatin 150 mg/day at 100 mg/m2 on the second day, every 3 weeks). The pharmacist helped her to avoid severe side effects. When the hepatic metastases disappeared after 13 courses, the primary MCN was removed surgically after 16 courses of GEMOX treatment. No recurrence has been observed 22 months postoperatively. GEMOX might be effective for the treatment of MCN of the pancreas.
authors.affiliation: Dept. of Pharmacy, Gunma University Hospital.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Obayashi
authors.forename: Susumu
authors.initials: S
authors.lastname: Ohwada
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sunose
authors.forename: Koujirou
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Rie
authors.initials: R
authors.lastname: Igarashi
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Hamada
authors.forename: Izumi
authors.initials: I
authors.lastname: Takeyoshi
authors.forename: Ryuya
authors.initials: R
authors.lastname: Horiuchi
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018291:Cystadenoma, Mucinous / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008279:Magnetic Resonance Imaging; D009362:Neoplasm Metastasis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D009367:Neoplasm Staging; D009944:Organoplatinum Compounds / Q000627:therapeutic use*; D000077150:Oxaliplatin; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D011859:Radiography; D000093542:Gemcitabine
chemical_list: D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D003841:Deoxycytidine; D000093542:Gemcitabine