Protein quality control: on IPODs and other JUNQ.
The accumulation of misfolded cytosolic or aggregation-prone proteins leads to cellular stress. To protect the cell, damaged or aggregated proteins are actively sequestered in two newly discovered quality control compartments, JUNQ and IPOD, which are highly conserved in evolution.
Bagola
Katrin
K
Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Str.10, 13125 Berlin, Germany.
Sommer
Thomas
T
D002451:Cell Compartmentation; D017510:Protein Folding; D011506:Proteins / Q000378:metabolism*; D013312:Stress, Physiological; D054875:Ubiquitination
D011506:Proteins