title: Sudden cardiac death in a young HIV-positive man on effective antiretroviral therapy.
abstract: We describe the case of a young HIV-positive man on effective HAART with excellent viro-immunological control who presented a massive cardiac infarction. Despite the presence of clinical risk factors for cardiovascular disease, the patient had normal arterial carotid IMT values, known to be strong predictors of atherosclerosis and stroke. Interestingly, parameters of T-cell activation (CD8+CD38+) were shown to increase just before the onset of myocardial infarction. As T-cell activation is known to mediate atherosclerosis, the authors suggest that surrogate immunologic markers should be identified to better assess cardiovascular risk in the setting of HIV infection.
authors.affiliation: Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases and Tropical Medicine, San Paolo Hospital, University of Milan, Italy. camilla.tincati@gmail.com
authors.forename: Camilla
authors.initials: C
authors.lastname: Tincati
authors.forename: Dario
authors.initials: D
authors.lastname: Bauer
authors.forename: Giusi M
authors.initials: GM
authors.lastname: Bellistrì
authors.forename: Maddalena
authors.initials: M
authors.lastname: Casana
authors.forename: Roberto
authors.initials: R
authors.lastname: Ranieri
authors.forename: Teresa
authors.initials: T
authors.lastname: Bini
authors.forename: Giulia
authors.initials: G
authors.lastname: Marchetti
authors.forename: Antonella
authors.initials: A
authors.lastname: d'Arminio Monforte
mesh_terms: D051997:ADP-ribosyl Cyclase 1 / Q000032:analysis; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D018414:CD8-Positive T-Lymphocytes / Q000737:chemistry / Q000276:immunology; D016757:Death, Sudden, Cardiac; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D008297:Male
chemical_list: D051997:ADP-ribosyl Cyclase 1