title: Breast conserving treatment (BCT) for stage I-II breast cancer in elderly women: analysis of 927 cases.
abstract: BACKGROUND
  Few breast conserving treatment (BCT) data include women older than 70.
  
  
  METHODS
  910 women older than 70 were treated by BCT for stage I-II BC, with 670 pT(1) (72.3%), 245 pT(2) (26.4%) and 12 pT(x) (1.3%). Axillary nodal involvement occurred in 30.7% of cases. ER and PgR were positive in 85% and 71% of cases. Radiotherapy (RT) was delivered in all patients, tamoxifen in 55.8% and chemotherapy in 4.8%.
  
  
  RESULTS
  With a 65-month median follow-up, 28 (3%) local recurrences (LR) and 83 (9.1%) metastases occurred. Second cancer occurred in 51 (5.6%) patients. The 8-year overall survival (OS) and disease-specific survival (DSS) rates were 74% and 90%. The 8-year OS and DSS rates were 77% and 92% versus 65% and 84% in pT(1) versus pT(2) patients (p=0.01). 676 patients were in complete remission (74.3%); 22 were evolutive (2.4%). 206 patients died (22.6%).
  
  
  CONCLUSIONS
  Our study confirms the excellent local control in elderly patients treated by BCT with RT and identifies subgroups at high risk of distant relapse that should be treated more aggressively.
authors.affiliation: Department of Radiation Oncology, Polyclinique de Courlancy, 38 rue de Courlancy, 51100 Reims, France. bcutuli@oncorad.courlancy.fr
authors.forename: Bruno
authors.initials: B
authors.lastname: Cutuli
authors.forename: Brigitte
authors.initials: B
authors.lastname: De Lafontan
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Vitali
authors.forename: Loredana
authors.initials: L
authors.lastname: Costa
authors.forename: Cynthia
authors.initials: C
authors.lastname: Aristei
authors.forename: Christian
authors.initials: C
authors.lastname: Marchal
authors.forename: Philippe
authors.initials: P
authors.lastname: Quetin
authors.forename: Renaud
authors.initials: R
authors.lastname: Fay
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents; D001943:Breast Neoplasms / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D011878:Radiotherapy; D013514:Surgical Procedures, Operative; D015996:Survival Rate
chemical_list: D000970:Antineoplastic Agents