title: Difference in number of loci of swine leukocyte antigen classical class I genes among haplotypes.
abstract: The structure of the entire genomic region of swine leukocyte antigen (SLA)-the porcine major histocompatibility complex--was recently elucidated in a particular haplotype named Hp-1.0 (H01). However, it has been suggested that there are differences in the number of loci of SLA genes, particularly classical class I genes, among haplotypes. To clarify the between-haplotype copy number variance in genes of the SLA region, we sequenced the genomic region carrying SLA classical class I genes on two different haplotypes, revealing increments of up to six in the number of classical class I genes in a single haplotype. All of the SLA-1(-like) (SLA-1 and newly designated SLA-12) and SLA-3 genes detected in the haplotypes thus analyzed were transcribed in the individual. The process by which duplication of SLA classical class I genes was likely to have occurred was interpreted from an analysis of repetitive sequences adjacent to the duplicated class I genes.
authors.affiliation: Second Research Division, Institute of Society for Techno-innovation of Agriculture, Forestry and Fisheries, Kamiyokoba, Tsukuba, Ibaraki, Japan.
authors.forename: Maiko
authors.initials: M
authors.lastname: Tanaka-Matsuda
authors.forename: Asako
authors.initials: A
authors.lastname: Ando
authors.forename: Claire
authors.initials: C
authors.lastname: Rogel-Gaillard
authors.forename: Patrick
authors.initials: P
authors.lastname: Chardon
authors.forename: Hirohide
authors.initials: H
authors.lastname: Uenishi
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D022202:Chromosomes, Artificial, Bacterial; D020440:Gene Duplication; D005786:Gene Expression Regulation; D005805:Genes, MHC Class I / Q000235:genetics*; D014644:Genetic Variation; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D000949:Histocompatibility Antigens Class II; D008969:Molecular Sequence Data; D010802:Phylogeny; D013552:Swine / Q000235:genetics* / Q000276:immunology
chemical_list: D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; C438668:swine leukocyte antigen