title: Chapter 7. Mouse models of ischemic angiogenesis and ischemia-reperfusion injury.
abstract: Ischemia and ischemia-reperfusion (I/R) events are distinct but interrelated processes etiologic to the most prevalent human diseases. A delicate balance exists whereby ischemic injury can result in beneficial angiogenesis or in detrimental reperfusion injury overwhelming the organism. Here, we describe in vivo models of ischemia and ischemia-reperfusion injury with emphasis on murine hindlimb ischemia models. We also provide a brief introduction to murine myocardial ischemia experiments. Each model is described in the context of human disease. Emphasis is made on the strengths and weaknesses of the available techniques, particularly as it relates to data analysis, interpretation, and translational relevance.
authors.affiliation: Section of Vascular and Endovascular Surgery, Department of Surgery, School of Medicine, University of California San Diego, San Diego, California, USA.
authors.forename: Joshua I
authors.initials: JI
authors.lastname: Greenberg
authors.forename: Ahmed
authors.initials: A
authors.lastname: Suliman
authors.forename: Samuel
authors.initials: S
authors.lastname: Barillas
authors.forename: Niren
authors.initials: N
authors.lastname: Angle
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006614:Hindlimb / Q000098:blood supply / Q000293:injuries; D006801:Humans; D051379:Mice; D009203:Myocardial Infarction; D009389:Neovascularization, Pathologic; D015427:Reperfusion Injury