title: A catechin-rich beverage improves obesity and blood glucose control in patients with type 2 diabetes.
abstract: We investigated the effects of continuous ingestion of a catechin-rich beverage in patients with type 2 diabetes who were not receiving insulin (Ins) therapy in a double-blind controlled study. The participants ingested green tea containing either 582.8 mg of catechins (catechin group; n = 23) or 96.3 mg of catechins (control group; n = 20) per day for 12 weeks. At week 12, the decrease in waist circumference was significantly greater in the catechin group than in the control group. Adiponectin, which is negatively correlated with visceral adiposity, increased significantly only in the catechin group. Although the increase in Ins at week 12 was significantly greater in the catechin group than in the control group, no apparent difference was noted between the two groups in glucose and hemoglobin A(1c). In patients treated with insulinotropic agents, the increase in Ins at week 12 was significantly greater in the catechin group than in the control group. This significant increase in Ins levels was observed only in the catechin group. In the catechin group receiving other treatments, Ins levels remained unchanged. In addition, in patients treated with insulinotropic agents, the decrease in hemoglobin A(1c) at week 12 was significantly greater in the catechin group than in the control group. These results suggest that a catechin-rich beverage might have several therapeutic uses: in the prevention of obesity; in the recovery of Ins-secretory ability; and, as a way to maintain low hemoglobin A(1c) levels in type 2 diabetic patients who do not yet require Ins therapy.
authors.affiliation: Health Care Food Research Laboratories, Kao Corporation, Tokyo, Japan. nagao.tomonori@kao.co.jp
authors.forename: Tomonori
authors.initials: T
authors.lastname: Nagao
authors.forename: Shinichi
authors.initials: S
authors.lastname: Meguro
authors.forename: Tadashi
authors.initials: T
authors.lastname: Hase
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Otsuka
authors.forename: Masanori
authors.initials: M
authors.lastname: Komikado
authors.forename: Ichiro
authors.initials: I
authors.lastname: Tokimitsu
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Kunio
authors.initials: K
authors.lastname: Yamamoto
mesh_terms: D052242:Adiponectin / Q000378:metabolism; D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D000368:Aged; D001628:Beverages; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002392:Catechin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D004311:Double-Blind Method; D005260:Female; D006442:Glycated Hemoglobin / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use; D050356:Lipid Metabolism / Q000187:drug effects / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D002392:Catechin; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents