title: Potential of different techniques of preferential crystallization for enantioseparation of racemic compound forming systems.
abstract: Recently the feasibility of preferential crystallization for enantioseparation of racemic compound forming systems has been demonstrated (Lorenz et al., Application of preferential crystallization to resolve racemic compounds in a hybrid process. Chirality 2006;18:828-840; Polenske et al., Separation of the propranolol hydrochloride enantiomers by preferential crystallization: thermodynamic basis and experimental verification. Cryst Growth Des 2007;7:1628-1634). Here, the development and the potential of an efficient separation process operated via two different techniques of preferential crystallization are studied: (1) seeded isothermal preferential crystallization and (2) auto-seeded polythermal preferential crystallization. Both techniques were investigated in the batch and in the cyclic operation mode. On the example of mandelic acid as a typical racemic compound forming system, it is demonstrated that a cyclic auto-seeded polythermal process is feasible and significantly more efficient than the seeded isothermal one.
authors.affiliation: Max-Planck-Institut für Dynamik komplexer technischer Systeme, Magdeburg, Germany. polenske@mpi-magdeburg.mpg.de
authors.forename: Daniel
authors.initials: D
authors.lastname: Polenske
authors.forename: Heike
authors.initials: H
authors.lastname: Lorenz
authors.forename: Andreas
authors.initials: A
authors.lastname: Seidel-Morgenstern