[Aspirin and other nonsteroidal anti-inflammatory drugs hypersensitivity--mechanisms, diagnostics and treatment].
Aspirin hypersensitivity syndrome includes several symptoms from the respiratory tract, skin and digestive system triggered by ingestion of aspirin or other nonsteroidal anti-inflammatory drugs. Asthmatic attacks precipitated by aspirin or other nonsteroidal anti-inflammatory drugs occur in about 10% of all asthmatic patients. In subjects with aspirin hypersensitivity disruption of synthesis of prostaglandin E2 (PGE2) and overproduction of cysteinyl leukotrienes (Cys-LT) seem to be crucial in the pathogenesis of bronchial symptoms. Double blind, placebo controlled challenges are regarded as a gold standard in the diagnosis of aspirin hypersensitivity.
Kupczyk
Maciej
M
Klinika Chorób Wewnetrznych, Astmy i Alergii Uniwersytetu Medycznego w Lodzi Kierownik.
Kuna
Piotr
P
D000485:Allergens / Q000008:administration & dosage / Q000009:adverse effects*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced* / Q000175:diagnosis* / Q000378:metabolism / Q000517:prevention & control; D015232:Dinoprostone / Q000378:metabolism; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology* / Q000378:metabolism / Q000517:prevention & control; D006801:Humans; D018077:Receptors, Leukotriene / Q000378:metabolism
D000485:Allergens; D000894:Anti-Inflammatory Agents, Non-Steroidal; D018077:Receptors, Leukotriene; D015232:Dinoprostone; D001241:Aspirin