[The significance of Gc-globulin in clinical practice].
Gc-globulin is a multifunctional glycoprotein with a molecular mass of 51-58 kDa. It is also called vitamin D-binding protein (DBP). The main function of Gc-globulin is to bind vitamin D and actin, which is released into the extracellular environment upon cell and tissue lysis. Gc-globulin appears to have important clinical significance. Some investigation have shown that a low concentration of Gc-globulin may be used as a prognostic factor in patients with fulminant hepatic failure, acetaminophen (paracetamol) overdose, multiple trauma or multiple organ dysfunction syndrome (MODS), or sepsis. Many studies suggest an association between Gc-globulin phenotypes and resistance or susceptibility to chronic obstructive pulmonary disease (COPD), thyroid diseases, diabetes, multiple sclerosis, and sarcoidosis.
Łukaszewicz-Zajac
Marta
M
Zakład Diagnostyki Biochemicznej Uniwersytetu Medycznego, 15-269 Białystok. martha_21@interia.pl
Mroczko
Barbara
B
Kułakowska
Alina
A
Szmitkowski
Maciej
M
D000199:Actins / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D006801:Humans; D017114:Liver Failure, Acute / Q000175:diagnosis / Q000188:drug therapy; D009104:Multiple Trauma / Q000175:diagnosis / Q000378:metabolism; D011379:Prognosis; D018805:Sepsis / Q000175:diagnosis / Q000188:drug therapy; D014807:Vitamin D / Q000378:metabolism; D014809:Vitamin D-Binding Protein / Q000378:metabolism*
D000199:Actins; D015415:Biomarkers; D014809:Vitamin D-Binding Protein; D014807:Vitamin D