title: Antinociceptive activity of swertiamarin isolated from Enicostemma axillare.
abstract: Many traditional Indian medicinal plants which contain large quantity of a secoiridoid, swertiamarin are being used to relieve pain. Iridoids present in a wide variety of medicinal plants possess a large number of medicinal properties. In the present study in vivo antinociceptive activity of swertiamarin isolated from E. axillare was carried out using three different methods in mice. In the hot plate method, a significant increase in the latency period was observed for the treatment with swertiamarin at 100 and 200 mg/kg bw after 30 and 45 min. The percent protection observed after 45 min was 109.42, 147.42 and 157.14, respectively, for the standard paracetamol and swertiamarin at 100 and 200 mg/kg bw treatments. A significant increase in the tail withdrawal reflex was observed for the swertiamarin treatment at both the doses with percent protections of 150 and 200, respectively. In both these methods, swertiamarin produced potent activity than that of standard paracetamol. In the acetic acid induced writhing, swertiamarin at 100 and 200 mg/kg bw reduced the number of writhes significantly. Dose dependent results were observed in all the three methods and among the two doses, swertiamarin at 200 mg/kg bw showed potent activity. These results prove that swertiamarin possess both peripheral and central antinociceptive activity.
authors.affiliation: Department of Pharmaceutical Chemistry, J.S.S. College of Pharmacy, Ootacamund-643001, Tamil Nadu, India.
authors.forename: V
authors.initials: V
authors.lastname: Jaishree
authors.forename: S
authors.initials: S
authors.lastname: Badami
authors.forename: M
authors.initials: M
authors.lastname: Rupesh Kumar
authors.forename: T
authors.initials: T
authors.lastname: Tamizhmani
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use; D019342:Acetic Acid / Q000009:adverse effects; D000700:Analgesics / Q000627:therapeutic use*; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use; D000818:Animals; D029965:Gentianaceae / Q000737:chemistry; D005960:Glucosides / Q000627:therapeutic use*; D057888:Iridoid Glucosides; D039823:Iridoids / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D011753:Pyrones / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013623:Tail
chemical_list: D000700:Analgesics; D018712:Analgesics, Non-Narcotic; D005960:Glucosides; D057888:Iridoid Glucosides; D039823:Iridoids; D010936:Plant Extracts; D011753:Pyrones; D000082:Acetaminophen; C013270:swertiamarin; D019342:Acetic Acid