Historical perspective and clinical implications of the Pelger-Hüet cell.
The unique historical aspects of Pelger and Huet's discovery of the Pelger-Huet cell highlight the diagnostic challenge that this morphologic finding presents to the physician. Making the diagnosis of the benign autosomal dominant anomaly is complicated by the morphologically similar pseudo-Pelger-Huet cell, which can signify underlying myeloid dsyplasia. This article relates the history of the Pelger-Huet anomaly as well as describes the clinical significance and diagnostic workup for the finding of a Pelger-Huet cell on peripheral smear.
Cunningham
John M
JM
University of Minnesota Twin Cities, Medical School, Minneapolis, Minnesota 55455, USA. cunni184@umn.edu
Patnaik
Mrinal M
MM
Hammerschmidt
Dale E
DE
Vercellotti
Gregory M
GM
D000818:Animals; D002467:Cell Nucleus / Q000648:ultrastructure; D002648:Child; D003937:Diagnosis, Differential; D004804:Eosinophils / Q000473:pathology; D005260:Female; D005313:Fetal Death / Q000235:genetics; D005799:Genes, Dominant; D049673:History, 20th Century; D006801:Humans; D007239:Infections / Q000097:blood; D007951:Leukemia, Myeloid / Q000097:blood / Q000175:diagnosis; D009190:Myelodysplastic Syndromes / Q000097:blood / Q000175:diagnosis; D009426:Netherlands; D009504:Neutrophils / Q000473:pathology*; D010375:Pedigree; D010381:Pelger-Huet Anomaly / Q000097:blood / Q000175:diagnosis / Q000235:genetics / Q000266:history; D018160:Receptors, Cytoplasmic and Nuclear / Q000172:deficiency / Q000235:genetics; D000097682:Lamin B Receptor
D018160:Receptors, Cytoplasmic and Nuclear; D000097682:Lamin B Receptor