Drugs with anticholinergic properties as a risk factor for cognitive impairment in elderly people: a population-based study.
Prevention of drug-related problems is a key issue in the aged. Anticholinergic (ACH) drugs are a biologically plausible and potentially modifiable risk factor for cognitive impairment. Therefore, we intended to evaluate the association between ACH drugs and cognitive impairment. Our study comprised 750 subjects aged 65 years or older. Cognitive impairment was evaluated using Mini-Mental State Examination and Global Deterioration Scale. Patients were classified into ACH-drug users and non-ACH-drug users. Those using ACH drugs (20.1%) were more likely to have cognitive impairment than those using non-ACH drugs (odds ratio, 3.18; 95% confidence interval, 1.93-5.23; P < 0.001); this association remained significant even after adjusting for potential confounding variables (odds ratio, 2.30; 95% confidence interval, 1.19-4.45). Our data suggest that ACH drug intake should be regarded a potentially modifiable risk factor for cognitive impairment in the elderly.
Cancelli
Iacopo
I
Department of Neurology, S. Maria della Misericordia University Hospital, University of Udine Medical School, Udine, Italy.
Gigli
Gian Luigi
GL
Piani
Antonella
A
Zanchettin
Barbara
B
Janes
Francesco
F
Rinaldi
Adriana
A
Valente
Mariarosaria
M
D017677:Age Distribution; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D018680:Cholinergic Antagonists / Q000009:adverse effects*; D003071:Cognition / Q000187:drug effects*; D003072:Cognition Disorders / Q000139:chemically induced* / Q000523:psychology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007558:Italy; D008297:Male; D016017:Odds Ratio; D011159:Population Surveillance; D011569:Psychiatric Status Rating Scales; D018570:Risk Assessment; D012307:Risk Factors
D018680:Cholinergic Antagonists