title: Vilsmeier reaction of enaminones: efficient synthesis of halogenated pyridin-2(1H)-ones.
abstract: A facile and efficient one-pot synthesis of halogenated pyridin-2(1H)-ones from a series of readily available enaminones under Vilsmeier conditions is described, and a mechanism involving sequential halogenation, formylation, and intramolecular nucleophilic cyclization is proposed.
authors.affiliation: Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.forename: Dingyuan
authors.initials: D
authors.lastname: Zhang
authors.forename: Yongli
authors.initials: Y
authors.lastname: Guo
authors.forename: Guangyuan
authors.initials: G
authors.lastname: Zhou
authors.forename: Zijiang
authors.initials: Z
authors.lastname: Jiang
authors.forename: Dewen
authors.initials: D
authors.lastname: Dong
mesh_terms: D000588:Amines / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods*; D015195:Drug Design; D006219:Halogens / Q000737:chemistry*; D008956:Models, Chemical; D009584:Nitrogen / Q000737:chemistry; D010100:Oxygen / Q000737:chemistry; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D011728:Pyridones / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry; D013696:Temperature
chemical_list: D000588:Amines; D006219:Halogens; D011725:Pyridines; D011728:Pyridones; D002244:Carbon; D012822:Silicon Dioxide; D009584:Nitrogen; D010100:Oxygen