title: Cancer among Scandinavian women with cosmetic breast implants: a pooled long-term follow-up study.
abstract: No increased risks of specific types of cancer following breast implantation have been consistently reported, but data on risk beyond 15 years are limited. We have pooled the results of 2 nationwide cohort studies of 3,486 Swedish and 2,736 Danish women who underwent cosmetic breast implantation between 1965 and 1993. Cancer incidence through 2002 was ascertained through nationwide cancer registries. Standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) were calculated to compare cancer incidence among women with implants with women in the general population. Mean duration of follow up was 16.6 years (range 0.1-37.8 years). Over 50% of women were followed for 15 years or more after breast implantation and 13.3% for at least 25 years. There was a reduced incidence of breast cancer (SIR=0.73; 95% CI 0.58-0.90), whereas lung cancer was above expectation (SIR=1.64; 95% CI 1.10-2.36). The increased risk of lung cancer is expected due to the high prevalence of smoking among the women with implants in our study. With respect to other site-specific cancers, no significantly increased or decreased SIR was observed. This study, which includes women followed for almost 4 decades, represents the longest follow up of women with cosmetic breast implants to date. The results provide no evidence of an association between breast implants and any type of cancer.
authors.affiliation: International Epidemiology Institute, Rockville, MD 20850, USA.
authors.forename: Loren
authors.initials: L
authors.lastname: Lipworth
authors.forename: Robert E
authors.initials: RE
authors.lastname: Tarone
authors.forename: Søren
authors.initials: S
authors.lastname: Friis
authors.forename: Weimin
authors.initials: W
authors.lastname: Ye
authors.forename: Jørgen H
authors.initials: JH
authors.lastname: Olsen
authors.forename: Olof
authors.initials: O
authors.lastname: Nyren
authors.forename: Joseph K
authors.initials: JK
authors.lastname: McLaughlin
mesh_terms: D000328:Adult; D000368:Aged; D019928:Breast Implantation / Q000009:adverse effects*; D018427:Breast Implants / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D015331:Cohort Studies; D003718:Denmark; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D012307:Risk Factors; D013548:Sweden