title: Ductopapillary apocrine carcinoma of the eyelid metastatic to the parotid gland: report of a case diagnosed by fine-needle aspiration biopsy.
abstract: Ductopapillary apocrine carcinoma (DPAC) of the eyelid is a rare malignant neoplasm in the periocular region. The relative rarity of this tumor is a diagnostic challenge to the cytopathologist, especially when present as a metastatic lesion to an intraparotid lymph node, where the differential diagnosis includes primary parotid neoplasms, as well as various other metastatic malignancies. There are only a few reported cases of recurrent and metastatic DPAC of the eyelid, and to our knowledge, metastatic DPAC diagnosed by fine-needle aspiration biopsy (FNAB) has not been described. We report a case of a 65-year-old African-American male with a history of ductopapillary apocrine adenocarcinoma of the eyelid, diagnosed 6 weeks ago now presenting with a recurrence in the same area. Magnetic resonance imaging of the head and neck revealed an intraparotid mass also. FNAB of the parotid mass showed a well-differentiated papillary adenocarcinoma with a cystic component, similar to a previously excised ductopapillary apocrine adenocarcinoma of the eyelid.
authors.affiliation: Department of Cytopathology, University of Mississippi Medical Center, Jackson, Mississippi 39216-4505, USA. israha@hotmail.com
authors.forename: Israh
authors.initials: I
authors.lastname: Akhtar
authors.forename: Cristina Luminita
authors.initials: CL
authors.lastname: Ispas
authors.forename: Rhyne
authors.initials: R
authors.lastname: Flowers
authors.forename: Anwer
authors.initials: A
authors.lastname: Siddiqi
authors.forename: Lafarra
authors.initials: L
authors.lastname: Young
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Donnellan
authors.forename: Ken
authors.initials: K
authors.lastname: Heard
authors.forename: Mithra
authors.initials: M
authors.lastname: Baliga
mesh_terms: D000368:Aged; D044963:Biopsy, Fine-Needle; D002291:Carcinoma, Papillary / Q000175:diagnosis* / Q000556:secondary; D002352:Carrier Proteins / Q000032:analysis; D005142:Eyelid Neoplasms / Q000175:diagnosis* / Q000473:pathology; D006023:Glycoproteins / Q000032:analysis; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D026901:Membrane Transport Proteins; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000473:pathology; D010307:Parotid Neoplasms / Q000175:diagnosis* / Q000556:secondary; D013544:Sweat Gland Neoplasms / Q000175:diagnosis* / Q000473:pathology
chemical_list: D002352:Carrier Proteins; D006023:Glycoproteins; D026901:Membrane Transport Proteins; C488892:PIP protein, human