[Food-cobalamin syndrome].
Food-cobalamin malabsorption is a new well-characterized syndrome. In association with pernicious anemia, it is the leading etiology of cobalamin deficiency in adult, especially in elderly patient. Currently, it is an exclusion diagnosis that requires a well-codified clinical strategy for diagnosis. There are several causes of food-cobalamin malabsorption, mainly gastric disorders and drugs (metformin and anti-acid drugs). Current treatment modality includes oral cobalamin administration with lower doses than in pernicious anemia. Studies are in the way to better characterize the food-cobalamin malabsorption in a clinical practice perspective and to validate the usefulness of oral cobalamin therapy.
Serraj
Khalid
K
Service de médecine interne, diabète et maladies métaboliques, Clinique médicale B, Hôpitaux universitaires de Strasbourg, F-67091 Strasbourg, France.
Vogel
Thomas
T
Federici
Laure
L
Ciobanu
Ecaterina
E
Mecili
Mustapha
M
Kaltenbach
Georges
G
Andrès
Emmanuel
E
D000328:Adult; D000368:Aged; D000752:Anemia, Pernicious / Q000175:diagnosis / Q000188:drug therapy; D064420:Drug-Related Side Effects and Adverse Reactions; D005502:Food; D018565:Food-Drug Interactions; D006801:Humans; D007408:Intestinal Absorption / Q000502:physiology; D008286:Malabsorption Syndromes / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D013577:Syndrome; D014805:Vitamin B 12 / Q000378:metabolism* / Q000627:therapeutic use; D014806:Vitamin B 12 Deficiency / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D014803:Vitamin B Complex / Q000378:metabolism* / Q000627:therapeutic use
D014803:Vitamin B Complex; D014805:Vitamin B 12