title: Chemiluminescence thrombin aptasensor using high-activity DNAzyme as catalytic label.
abstract: With a designed high-activity DNAzyme as the catalytic label, an ultrasensitive chemiluminescence thrombin aptasensor is developed, enabling a 10- to 100-fold improvement in the detection sensitivity as compared with previous counterparts.
authors.affiliation: Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Erkang
authors.initials: E
authors.lastname: Wang
authors.forename: Shaojun
authors.initials: S
authors.lastname: Dong
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry / Q000378:metabolism*; D001483:Base Sequence; D055162:Biocatalysis; D021881:DNA, Catalytic / Q000737:chemistry / Q000378:metabolism*; D049449:Luminescence; D008163:Luminescent Measurements; D009690:Nucleic Acid Conformation; D012680:Sensitivity and Specificity; D013194:Staining and Labeling; D013917:Thrombin / Q000032:analysis*; D013997:Time Factors
chemical_list: D052157:Aptamers, Nucleotide; D021881:DNA, Catalytic; D013917:Thrombin