title: Chemokine receptors expression on T cells and response to HAART among chronic HIV-1-infected subjects.
abstract: Chemokines receptors are used by HIV-1 for entry into CD4(+) T cells. The beta-chemokines are capable of inhibiting HIV replication. This study determined the CCR5 and CXCR4 expression on T cells in HIV-1-infected patients treated with HAART. The successfully treated group (plasma viral load <400 copies/mL), when compared with the failure group (plasma viral load >400 copies/mL), had higher median CD4(+) T cells count (583 and 245 cells/mm(3); respectively, p< 0.0001). The failure patients had higher numbers and intensity of CCR5 and CXCR4-expressing T cells. Successfully treated patients were able to normalize the co-receptors expression-over on T cells. The viremic group showed higher CCR5 expression on CD4(+) T cells and lower number of cells; CCR5 expression was normalized in the aviremic group; the naïve group showed lower CCR5 expression and higher numbers of CD4 T cells; all groups showed normal CXCR4 expression compared to healthy controls. These findings may have clinical implications, since down-regulation of these co-receptors could be an adjuvant strategy for anti-HIV treatment.
authors.affiliation: Laboratory of Immunology and Dermatology, Department of Dermatology, Sao Paulo University Medical School, Sao Paulo, SP, Brazil.
authors.forename: Adriana
authors.initials: A
authors.lastname: Brito
authors.forename: Paula O
authors.initials: PO
authors.lastname: Rigato
authors.forename: Alexandre
authors.initials: A
authors.lastname: Almeida
authors.forename: Simone S
authors.initials: SS
authors.lastname: Fernandes
authors.forename: Cláudio R
authors.initials: CR
authors.lastname: Gonsalez
authors.forename: Luiz A M
authors.initials: LA
authors.lastname: Fonseca
authors.forename: Alberto J S
authors.initials: AJ
authors.lastname: Duarte
authors.forename: Jorge
authors.initials: J
authors.lastname: Casseb
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019713:Receptors, CCR5 / Q000096:biosynthesis*; D019718:Receptors, CXCR4 / Q000096:biosynthesis*; D013601:T-Lymphocytes / Q000276:immunology*; D014766:Viremia
chemical_list: C527276:CXCR4 protein, human; D019713:Receptors, CCR5; D019718:Receptors, CXCR4