title: Cytomegalovirus myopericarditis and hepatitis in an immunocompetent adult: successful treatment with oral valganciclovir.
abstract: Primary infection by cytomegalovirus (CMV) commonly occurs subclinically or manifested by a self-limited mononucleosis-like syndrome in immunocompetent subjects. Severe clinical pictures are uncommon. We present a case of acute myopericarditis and hepatitis in a previously healthy 32-year-old man with primary CMV infection, assessed by serology and positive pp65 antigenemia. He was successfully treated with a course of oral valganciclovir therapy, with an immediate clinical response and normalization of laboratory tests. The literature on simultaneous presentation of CMV pericarditis and hepatitis in immunocompetent hosts, as well as the role of oral valganciclovir in this clinical setting, is reviewed.
authors.affiliation: Department of Internal Medicine, University Hospital 12 de Octubre, Madrid, Spain. mario_fdezruiz@yahoo.es
authors.forename: Mario
authors.initials: M
authors.lastname: Fernández-Ruiz
authors.forename: Carolina
authors.initials: C
authors.lastname: Muñoz-Codoceo
authors.forename: Francisco
authors.initials: F
authors.lastname: López-Medrano
authors.forename: Regina
authors.initials: R
authors.lastname: Faré-García
authors.forename: Amparo
authors.initials: A
authors.lastname: Carbonell-Porras
authors.forename: Cristina
authors.initials: C
authors.lastname: Garfia-Castillo
authors.forename: Raquel
authors.initials: R
authors.lastname: Muñoz-Gómez
authors.forename: Jose María
authors.initials: JM
authors.lastname: Aguado-García
mesh_terms: D000284:Administration, Oral; D000328:Adult; D003587:Cytomegalovirus / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000188:drug therapy*; D015774:Ganciclovir / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006525:Hepatitis, Viral, Human / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007121:Immunocompetence / Q000187:drug effects*; D008297:Male; D009205:Myocarditis / Q000175:diagnosis / Q000188:drug therapy* / Q000821:virology; D010493:Pericarditis / Q000175:diagnosis / Q000188:drug therapy* / Q000821:virology; D016896:Treatment Outcome; D000077562:Valganciclovir
chemical_list: D000077562:Valganciclovir; D015774:Ganciclovir