Analgesic requirements after major abdominal surgery are associated with OPRM1 gene polymorphism genotype and haplotype.
OBJECTIVE
The association between SNPs of the human OPRM1 gene encoding the micro-opioid receptor and postoperative analgesic requirements in surgical patients remains controversial. Here, we evaluate whether any of the five tag SNPs (A118G, IVS2+G691C, IVS3+G5953A, IVS3+A8449G and TAA+A2109G) representing the four linkage disequilibrium blocks of the OPRM1 gene influences postoperative analgesic requirements.


METHODS
We studied 138 adult Japanese patients who underwent major open abdominal surgery under combined general and epidural anesthesia and received continuous postoperative epidural analgesia with opioids.


RESULTS
The 118G homozygous (GG) patients required 24-h postoperative analgesics more than 118A homozygous (AA) and heterozygous (AG) patients. Tag SNP haplotypes also were associated with 24-h postoperative analgesic requirements.


CONCLUSIONS
These results suggest that OPRM1 gene tag SNP genotypes and haplotypes can primarily contribute to prediction of postoperative analgesic requirements in individual patients undergoing major open abdominal surgery.
Hayashida
Masakazu
M
Division of Psychobiology, Tokyo Institute of Psychiatry, 2-1-8 Kamikitazawa, Setagaya-ku, Tokyo 156-8585, Japan.
Nagashima
Makoto
M
Satoh
Yasuo
Y
Katoh
Ryoji
R
Tagami
Megumi
M
Ide
Soichiro
S
Kasai
Shinya
S
Nishizawa
Daisuke
D
Ogai
Yasukazu
Y
Hasegawa
Junko
J
Komatsu
Hiroshi
H
Sora
Ichiro
I
Fukuda
Kenichi
K
Koga
Hisashi
H
Hanaoka
Kazuo
K
Ikeda
Kazutaka
K
D000005:Abdomen / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use*; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use; D013505:Digestive System Surgical Procedures; D004359:Drug Therapy, Combination; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000235:genetics / Q000517:prevention & control*; D020641:Polymorphism, Single Nucleotide; D017450:Receptors, Opioid, mu / Q000235:genetics*; D016896:Treatment Outcome
D000700:Analgesics; D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; C485764:OPRM1 protein, human; D017450:Receptors, Opioid, mu