title: Mandibular reconstruction after gunshot trauma in a dog by use of recombinant human bone morphogenetic protein-2.
abstract: METHODS
  A 6-year-old German Shorthaired Pointer was evaluated for possible reconstruction of a mandibular defect resulting from gunshot trauma.
  
  
  RESULTS
  A 5-cm defect of the right mandibular body was evident. A segment of the mandibular body was removed 9 weeks earlier because of severe contamination and comminution associated with gunshot trauma. Subsequent right-sided mandibular drift resulted in malocclusion in which the left mandibular canine tooth caused trauma to mucosa of the hard palate medial to the left maxillary canine tooth. The right maxillary canine tooth caused trauma to gingiva lingual to the right mandibular canine tooth.
  
  
  RESULTS
  The right mandible was stabilized with a 2.0-mm maxillofacial miniplate positioned along the lateral alveolar margin and a 2.4-mm locking mandibular reconstruction plate placed along the ventrolateral mandible. An absorbable compression-resistant matrix containing collagen, hydroxyapatite, and tricalcium phosphate was soaked in recombinant human bone morphogenetic protein-2 (rhBMP-2; 7.2 mL of a 0.5 mg/mL solution for a dose of 3.6 mg) and placed in the defect. By 4 weeks after surgery, an exuberant callus was evident at the site of the defect. By 7 months after surgery, the callus had remodeled, resulting in normal appearance, normal occlusion, and excellent function of the jaw.
  
  
  CONCLUSIONS
  Mandibular defects resulting from gunshot trauma can be treated by removal of contaminated tissue and comminuted bone fragments, followed by staged reconstruction. The combination of rhBMP-2 and compression-resistant matrix was effective in a staged mandibular reconstruction in a dog with a severe traumatic mandibular defect.
authors.affiliation: Matthew J. Ryan Veterinary Hospital, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6010, USA.
authors.forename: John R
authors.initials: JR
authors.lastname: Lewis
authors.forename: Randy J
authors.initials: RJ
authors.lastname: Boudrieau
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Reiter
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Seeherman
authors.forename: Robert S
authors.initials: RS
authors.lastname: Gilley
mesh_terms: D000818:Animals; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use*; D004285:Dogs; D006801:Humans; D008297:Male; D008334:Mandible / Q000473:pathology / Q000601:surgery; D008338:Mandibular Injuries / Q000601:surgery / Q000662:veterinary*; D011994:Recombinant Proteins / Q000627:therapeutic use*; D019651:Plastic Surgery Procedures / Q000379:methods / Q000662:veterinary*; D016212:Transforming Growth Factor beta / Q000627:therapeutic use*; D016896:Treatment Outcome; D014948:Wounds, Gunshot / Q000601:surgery / Q000662:veterinary*
chemical_list: D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; C499469:recombinant human bone morphogenetic protein-2