Intravascular lymphoma: an unusual diagnostic outcome of an incidentally detected adrenal mass.
OBJECTIVE
To describe a rare diagnosis of intravascular lymphoma in a patient presenting with an incidentally discovered adrenal mass.


METHODS
We describe the patient's clinical history and the findings from biochemical evaluation, radiologic studies, and surgical pathology and review the relevant literature.


RESULTS
A 43-year-old woman developed sudden onset of flank pain associated with a flushing sensation and presented to the emergency department where computed tomography showed a 5-cm left adrenal mass. She had normal electrolytes, and serum and urinary test results were negative for pheochromocytoma. A 24-hour urinary cortisol level was minimally elevated, and the midnight salivary cortisol value was within the reference range. Magnetic resonance imaging revealed a 6.5 x 5.8-cm left adrenal lesion that demonstrated moderate T2-weighted signal and gradual delayed enhancement with no drop in signal on out-of-phase images. Since the lesion lacked high intensity and the biochemical testing results did not suggest a pheochromocytoma, it was deemed likely that the mass was a malignant lesion of the left adrenal gland. A laparoscopic left adrenalectomy was performed. Morphologic and immunohistochemical findings were consistent with a large B-cell lymphoma, which by virtue of its near exclusive distribution in vascular spaces, was consistent with the diagnosis of intravascular large B-cell lymphoma.


CONCLUSIONS
Intravascular large B-cell lymphoma should be included in the differential diagnosis of an incidentally detected adrenal mass even though the diagnosis is rare.
Srivatsa
Sumathi
S
Department of Medicine, Division of Endocrinology Metabolism, and Lipids, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA.
Sharma
Jyotirmay
J
Logani
Sanjay
S
D000307:Adrenal Gland Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology*; D000328:Adult; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D014057:Tomography, X-Ray Computed