Separate areas for mirror responses and agency within the parietal operculum.
There is common neural activity in parietal and premotor cortex when executing and observing goal-directed movements: the "mirror" response. In addition, active and passive limb movements cause overlapping activity in premotor and somatosensory cortex. This association of motor and sensory activity cannot ascribe agency, the ability to discriminate between self- and non-self-generated events. This requires that some signals accompanying self-initiated limb movement dissociate from those evoked by observing the action of another or by movement imposed on oneself by external force. We demonstrated associated activity within the medial parietal operculum in response to feedforward visual or somatosensory information accompanying observed and imposed finger movements. In contrast, the response to motor and somatosensory information during self-initiated finger and observed movements resulted in activity localized to the lateral parietal operculum. This ascribes separate functions to medial and lateral second-order somatosensory cortex, anatomically dissociating the agent and the mirror response, demonstrating how executed and observed events are distinguished despite common activity in widespread sensorimotor cortices.
Agnew
Zarinah
Z
Cognitive Neuroimaging Group, Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Campus, London W12 0NN, United Kingdom. z.agnew@imperial.ac.uk
Wise
Richard J S
RJ
D000328:Adult; D001931:Brain Mapping; D005260:Female; D005385:Fingers / Q000502:physiology; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology*; D019370:Observation; D010100:Oxygen / Q000097:blood; D010296:Parietal Lobe / Q000098:blood supply / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology*; D055815:Young Adult
D010100:Oxygen