Real-time monitoring of blood using coherent anti-Stokes Raman spectroscopy.
We demonstrate a real-time method of measuring the vibrational Raman spectrum of whole blood. Using a novel coherent Raman technique, we record the vibrational spectrum of the red blood cells from picoliters in blood in milliseconds. This method will allow real-time in vivo blood monitoring.
Dogariu
Arthur
A
Princeton University, Applied Physics Group, Princeton, New Jersey 08544, USA. adogariu@princeton.edu
Goltsov
Alexander
A
Scully
Marlan O
MO
D001774:Blood Chemical Analysis / Q000295:instrumentation* / Q000379:methods; D003199:Computer Systems; D004867:Equipment Design; D019544:Equipment Failure Analysis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013059:Spectrum Analysis, Raman / Q000295:instrumentation* / Q000379:methods; D041623:Tomography, Optical Coherence / Q000295:instrumentation*