Tumor evasion may occur via expression of regulatory molecules: a case for CTLA-4 in melanoma.
Emerging data that show immune-regulating molecules may be ectopically expressed on human tumors suggest that novel mechanisms may induce tumor-related immune suppression, and support the use of antibodies and small molecules to target those immune-suppressive moities.
Weber
Jeffrey S
JS
H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA. jeffrey.weber@moffitt.org
D000818:Animals; D015703:Antigens, CD / Q000378:metabolism*; D060908:CTLA-4 Antigen; D006801:Humans; D007107:Immune System; D008213:Lymphocyte Activation; D008545:Melanoma / Q000276:immunology / Q000378:metabolism*; D051379:Mice; D009361:Neoplasm Invasiveness; D010641:Phenotype; D015398:Signal Transduction; D012878:Skin Neoplasms / Q000276:immunology / Q000378:metabolism*; D051153:Wnt Proteins / Q000378:metabolism
D015703:Antigens, CD; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; C556707:Ctla4 protein, mouse; D051153:Wnt Proteins