The plasmid-encoded regulator activates factors conferring lysozyme resistance on enteropathogenic Escherichia coli strains.
We demonstrate that enhanced lysozyme resistance of enteropathogenic Escherichia coli requires the plasmid-encoded regulator, Per, and is mediated by factors outside the locus for enterocyte effacement. EspC, a Per-activated serine protease autotransporter protein, conferred enhanced resistance on nonpathogenic E. coli, and a second Per-regulated, espC-independent lysozyme resistance mechanism was identified.
Salinger
Nina
N
Department of Biology, Haverford College, 370 Lancaster Avenue, Haverford, PA 19041, USA.
Kokona
Bashkim
B
Fairman
Robert
R
Okeke
Iruka N
IN
D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors*; D024881:Drug Resistance, Bacterial; D054308:Enteropathogenic Escherichia coli / Q000187:drug effects* / Q000235:genetics / Q000502:physiology*; D029968:Escherichia coli Proteins / Q000378:metabolism; D006801:Humans; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability; D008969:Molecular Sequence Data; D009113:Muramidase / Q000037:antagonists & inhibitors*; D010957:Plasmids; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D029968:Escherichia coli Proteins; C102541:EspC protein, E coli; D014157:Transcription Factors; D009113:Muramidase