Resveratrol regulates circadian clock genes in Rat-1 fibroblast cells.
Circadian clocks, especially peripheral clocks, can be strongly entrained by daily feedings, but few papers have reported the effects of food components on circadian rhythm. The effects of resveratrol, a natural polyphenol, on circadian clocks of Rat-1 cells were analyzed. A dose of 100 muM resveratrol, which did not show cytotoxicity, regulated the expression of clock genes Per1, Per2, and Bmal1.
Oike
Hideaki
H
National Food Research Institute (NFRI), National Agriculture and Food Research Organization (NARO), Tsukuba, Ibaraki, Japan. oike@affrc.go.jp
Kobori
Masuko
M
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002940:Circadian Rhythm / Q000187:drug effects* / Q000235:genetics*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D051381:Rats; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D013997:Time Factors
D013267:Stilbenes; D000077185:Resveratrol