[Role of the fatty acids in ovarian functions: involvement of peroxisome proliferator-activated receptors (PPAR) and adipokines].
The impact of nutrition and energy reserves on the reproductive functions is known for a very long time. However, the metabolic factors involved in the interactions between nutrition and reproduction are still poorly understood. These factors may be hormones or nutrients (glucose, protein and fatty acids). However, it remains to determine whether these factors act directly or indirectly on the reproductive tissues. In this issue, we briefly summarize the impact of fatty acids on the development of ovarian follicles, oocyte and embryo. We then discuss the current hypotheses about the mechanisms of action of these fatty acids on the ovarian functions. We describe more particularly the role of some receptors of fatty acids, Peroxisome Proliferator-Activated Receptors (PPAR) and Liver X Receptors (LXR) and two adipokines, leptin and adiponectin on ovarian cells.
Dupont
J
J
Unité de physiologie de la reproduction et des comportements, institut national de la recherche agronomique, 37380 Nouzilly, France. jdupont@tours.inra.fr
Froment
P
P
Ramé
C
C
Pierre
P
P
Coyral-Castel
S
S
Chabrolle
C
C
D054392:Adipokines / Q000378:metabolism / Q000502:physiology*; D004622:Embryo, Mammalian / Q000187:drug effects* / Q000502:physiology; D005227:Fatty Acids / Q000494:pharmacology*; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D009747:Nutritional Physiological Phenomena; D009865:Oocytes / Q000187:drug effects* / Q000502:physiology; D006080:Ovarian Follicle / Q000187:drug effects* / Q000502:physiology; D047492:Peroxisome Proliferator-Activated Receptors / Q000378:metabolism / Q000502:physiology*
D054392:Adipokines; D005227:Fatty Acids; D047492:Peroxisome Proliferator-Activated Receptors