title: Deletion 2p25.2: a cryptic chromosome abnormality in a patient with autism and mental retardation detected using aCGH.
abstract: We describe a 7-year-old patient with autism, moderate mental retardation, secondary microcephaly, agenesis of right optic nerve, and dysmorphic features carrying a de novo cryptic deletion of chromosome 2p25.2, detected by aCGH. Pure monosomies of 2p are very rare, and are usually observed as part of more complex aberrations involving other chromosomes. To the best of our knowledge, this is the first case presenting with a severe clinical phenotype and a de novo pure deletion of 2p25.2. The phenotypic effects of this rearrangement and the role of SOX11 gene, removed in our case, are herein discussed.
authors.forename: Adriana
authors.initials: A
authors.lastname: Lo-Castro
authors.forename: Grazia
authors.initials: G
authors.lastname: Giana
authors.forename: Marco
authors.initials: M
authors.lastname: Fichera
authors.forename: Lucia
authors.initials: L
authors.lastname: Castiglia
authors.forename: Lucia
authors.initials: L
authors.lastname: Grillo
authors.forename: Sebastiano Antonino
authors.initials: SA
authors.lastname: Musumeci
authors.forename: Cinzia
authors.initials: C
authors.lastname: Galasso
authors.forename: Paolo
authors.initials: P
authors.lastname: Curatolo
mesh_terms: D001321:Autistic Disorder / Q000235:genetics; D002648:Child; D002872:Chromosome Deletion; D025063:Chromosome Disorders / Q000235:genetics*; D002889:Chromosomes, Human, Pair 2; D055028:Comparative Genomic Hybridization; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics