GammaH2AX and cancer.
Histone H2AX phosphorylation on a serine four residues from the carboxyl terminus (producing gammaH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may lead to cancer but, paradoxically, are also used to kill cancer cells. Using gammaH2AX detection to determine the extent of DSB induction may help to detect precancerous cells, to stage cancers, to monitor the effectiveness of cancer therapies and to develop novel anticancer drugs.
Bonner
William M
WM
Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. bonnerw@mail.nih.gov
Redon
Christophe E
CE
Dickey
Jennifer S
JS
Nakamura
Asako J
AJ
Sedelnikova
Olga A
OA
Solier
Stéphanie
S
Pommier
Yves
Y
D000595:Amino Acid Sequence; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D053903:DNA Breaks, Double-Stranded; D004249:DNA Damage; D006657:Histones / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008322:Mammals; D051379:Mice; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology* / Q000517:prevention & control; D011230:Precancerous Conditions / Q000175:diagnosis; D011487:Protein Conformation; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction
D000970:Antineoplastic Agents; C468783:H2AX protein, human; D006657:Histones