Hypophagic and dipsogenic effect of the 5-HT1A receptor agonist 8-OH-DPAT in broiler chickens.
The effects of the 5-HT(1A) receptor agonist 8-OH-DPAT on food and water intake in male broiler chickens were investigated. The injection of 25 or 50 microg/kg of 8-OH-DPAT 15 min before refeeding in fasted animals produced a decrease in food intake. No effect was observed in drinking. The injection of 25 or 50 microg/kg of the 8-OH-DPAT 60 min after the start of refeeding did not produce any significant modification in food intake. No effect on drinking was recorded. The agonist 8-OH-DPAT injected 15 min before water presentation in water-deprived chickens, produced an increased drinking 60 min after the presentation of water. No effect on food intake was observed. The results show that the effect on food intake of the agonist 8-OH-DPAT in fasted-refed broiler chickens was similar to those observed in mammals and layer-strain chickens. However, the agonist did not alter significantly the food intake when the broilers were fed 60 min before the injection. These results are contrary to the observed effects in mammals and in layer-strain chickens. Probably, the selection for rapid growth rate in broilers causes modifications in the feeding control pattern. The comparison between broilers and layers strain may be a useful tool to elucidate the complex mechanisms involved in food and water intake regulation in chickens.
Saadoun
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Sección Fisiología y Nutrición, Departamento Básico de Medicina, Facultad de Ciencias & Unidad Asociada, Hospital de Clínicas, Montevideo, Uruguay. asaadoun@fcien.edu.uy
Cabrera
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D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000821:Animal Feed; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D002645:Chickens / Q000254:growth & development / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects* / Q000502:physiology; D004435:Eating / Q000187:drug effects* / Q000502:physiology; D005215:Fasting; D008297:Male; D044282:Receptor, Serotonin, 5-HT1A / Q000378:metabolism*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*
D017366:Serotonin Receptor Agonists; D044282:Receptor, Serotonin, 5-HT1A; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin