Vault-related resistance to anticancer drugs determined by the expression of the major vault protein LRP.
In this review we analyze the data supporting the notion that vault-related MDR, as reflected by LRP/MVP overexpression, represents a marker of drug resistance in vitro and in the clinic. Vaults, besides playing a fundamental biological role, may be involved in a novel mechanism of MDR.
Izquierdo
M A
MA
Department of Medical Oncology, Catalan Institute of Oncology, Av. Casteldefels Km 2.7, 08907 Hospitalet de LI., Barcelona, Spain.
Scheffer
G L
GL
Schroeijers
A B
AB
de Jong
M C
MC
Scheper
R J
RJ