Bone marrow stem cells transplanted to the testis of sterile mice do not differentiate into spermatogonial stem cells and have no protective effect on fertility.
Four months after transplanting bone marrow cells into the testis, no differentiation to spermatogonial stem cells was observed. Bone marrow transplantation had no protective effect on fertility after chemotherapy.
Van Saen
Dorien
D
Center for Reproductive Medicine and Research Laboratories for Reproductive Medicine, University Hospital and Medical School, Dutch-Speaking Brussels Free University, Vrije Universiteit Brussel, Brussels, Belgium. dorien.van.saen@vub.ac.be
Goossens
Ellen
E
De Block
Gert
G
Tournaye
Herman
H
D000818:Animals; D016026:Bone Marrow Transplantation; D002454:Cell Differentiation / Q000502:physiology; D004195:Disease Models, Animal; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000502:physiology; D007248:Infertility, Male / Q000601:surgery*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013091:Spermatogenesis / Q000502:physiology*; D013737:Testis / Q000166:cytology / Q000601:surgery*; D016896:Treatment Outcome