title: The correlation of thrombolysis in myocardial infarction frame count with insulin resistance in patients with slow coronary flow.
abstract: BACKGROUND
  It has been reported that coronary endothelial dysfunction plays an important pathogenetic role in patients with slow coronary flow (SCF). Insulin resistance is defined as impairment of insulin-stimulated glucose and/or lipid metabolism, while endothelial dysfunction is defined as paradoxical or inadequate endothelial-mediated vasodilation. In this study, we aimed to evaluate insulin resistance in patients with SCF.
  
  
  METHODS
  The study population included 25 patients with SCF and 28 healthy controls. Insulin resistance was estimated via homeostasis model assessment insulin resistance index (HOMA-IR).
  
  
  RESULTS
  Patients with SCF had higher high-sensitive C-reactive protein (hs-CRP) and HOMA-IR scores (P<0.05) than controls. Mean thrombolysis in myocardial infarction frame count had significant correlation with hs-CRP, fasting plasma insulin levels and HOMA-IR score (r=0.566, P<0.05; r=0.883, P<0.05; r=0.884, P<0.05, respectively).
  
  
  CONCLUSIONS
  In patients with SCF, thrombolysis in myocardial infarction frame counts and hs-CRP are correlated with increased insulin resistance and thus, it can be suggested that insulin resistance and inflammation may, in part, have a role in the pathogenesis of SCF.
authors.affiliation: Department of Cardiology, Mersin University Medical Faculty, Mersin, Turkey.
authors.forename: Turkay
authors.initials: T
authors.lastname: Ozcan
authors.forename: Ramazan
authors.initials: R
authors.lastname: Gen
authors.forename: Esen
authors.initials: E
authors.lastname: Akbay
authors.forename: Mehmet
authors.initials: M
authors.lastname: Horoz
authors.forename: Burak
authors.initials: B
authors.lastname: Akcay
authors.forename: Gultekin
authors.initials: G
authors.lastname: Genctoy
authors.forename: Necati
authors.initials: N
authors.lastname: Muslu
authors.forename: Ahmet
authors.initials: A
authors.lastname: Camsari
authors.forename: Dilek
authors.initials: D
authors.lastname: Cicek
authors.forename: Ebru
authors.initials: E
authors.lastname: Gok
authors.forename: Ahmet
authors.initials: A
authors.lastname: Kiykim
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001783:Blood Flow Velocity; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D002932:Cineangiography; D003287:Contrast Media; D017023:Coronary Angiography; D003326:Coronary Circulation; D003327:Coronary Disease / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003331:Coronary Vessels / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D007472:Iohexol / Q000031:analogs & derivatives; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D009203:Myocardial Infarction / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D015912:Thrombolytic Therapy; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D003287:Contrast Media; D018836:Inflammation Mediators; D007328:Insulin; D007472:Iohexol; C038192:iopromide; D002097:C-Reactive Protein