title: Scaffolding in tissue engineering: general approaches and tissue-specific considerations.
abstract: Scaffolds represent important components for tissue engineering. However, researchers often encounter an enormous variety of choices when selecting scaffolds for tissue engineering. This paper aims to review the functions of scaffolds and the major scaffolding approaches as important guidelines for selecting scaffolds and discuss the tissue-specific considerations for scaffolding, using intervertebral disc as an example.
authors.affiliation: Medical Engineering Program, Department of Mechanical Engineering, The University of Hong Kong, Room 711, Haking Wong Building, Pokfulam Road, Hong Kong SAR, China. bpchan@hkucc.hku.hk
authors.forename: B P
authors.initials: BP
authors.lastname: Chan
authors.forename: K W
authors.initials: KW
authors.lastname: Leong
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D019902:Chondrocytes / Q000166:cytology / Q000378:metabolism / Q000637:transplantation; D005109:Extracellular Matrix / Q000737:chemistry / Q000378:metabolism / Q000637:transplantation; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology / Q000627:therapeutic use; D007403:Intervertebral Disc / Q000166:cytology / Q000378:metabolism / Q000601:surgery; D007405:Intervertebral Disc Displacement / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D012038:Regeneration / Q000187:drug effects / Q000502:physiology; D023822:Tissue Engineering / Q000379:methods* / Q000639:trends*; D054457:Tissue Scaffolds / Q000592:standards / Q000639:trends*
chemical_list: D001672:Biocompatible Materials; D036341:Intercellular Signaling Peptides and Proteins