title: The molecular evolutionary history of Shigella spp. and enteroinvasive Escherichia coli.
abstract: Shigellosis, which caused by Shigella and enteroinvasive Escherichia coli (EIEC), was still a threat to public health. Compelling evidence indicates that Shigella species and EIEC are derived from multiple origins of E. coli and form a single pathovar. EIEC strains are regarded as precursors of 'full-blown'Shigella evolved from E. coli. By gain and loss of functions, Shigella and EIEC became successful human pathogens through convergent evolution from diverse genomic backgrounds.
authors.affiliation: State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Junping
authors.initials: J
authors.lastname: Peng
authors.forename: Jian
authors.initials: J
authors.lastname: Yang
authors.forename: Qi
authors.initials: Q
authors.lastname: Jin
mesh_terms: D000818:Animals; D055028:Comparative Genomic Hybridization; D004405:Dysentery, Bacillary / Q000382:microbiology* / Q000473:pathology; D004926:Escherichia coli / Q000235:genetics* / Q000472:pathogenicity; D019143:Evolution, Molecular; D014644:Genetic Variation; D016680:Genome, Bacterial; D006801:Humans; D010802:Phylogeny; D012760:Shigella / Q000235:genetics* / Q000472:pathogenicity; D037521:Virulence Factors / Q000235:genetics
chemical_list: D037521:Virulence Factors