Vasodilatation effect of farnesylacetones, active constituents of Sargassum siliquastrum, on the basilar and carotid arteries of rabbits.
Two farnesylacetones, 311 and 312, major active constituents of Sargassum siliquastrum collected from the coast of the East Sea in Korea, showed a moderate vasodilatation effect on the basilar arteries of rabbits. Therefore, treatment with farnesylacetones 311 and 312 may selectively accelerate cerebral blood flow through dilatation of the basilar artery.
Park
Byong-Gon
BG
Department of Physiology, Kwandong University College of Medicine, Gangneung 210-701, Republic of Korea.
Kwon
Seong-Chun
SC
Park
Gab-Man
GM
Ham
Jungyeob
J
Shin
Woon-Seob
WS
Lee
Seokjoon
S
D000818:Animals; D001488:Basilar Artery / Q000187:drug effects*; D001783:Blood Flow Velocity / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000188:drug therapy; D002339:Carotid Arteries / Q000187:drug effects*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D008956:Models, Chemical; D011817:Rabbits; D044647:Sargassum / Q000378:metabolism*; D013729:Terpenes / Q000737:chemistry*; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000138:chemical synthesis* / Q000494:pharmacology*
D013729:Terpenes; D014665:Vasodilator Agents; C014549:farnesylacetone