Plugging gp120s cavity.
NBD-556 is a class of HIV-1 entry inhibitors that binds HIV-1 surface glycoprotein gp120 and induces conformational changes, which mimic those caused by CD4 binding. Here, Madani et al. (2008) show that NBD-556 binds to the highly conserved "Phe-43 cavity" on gp120.
Repik
Alexander
A
Program in Molecular Medicine and Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Clapham
Paul R
PR
D015704:CD4 Antigens / Q000737:chemistry / Q000502:physiology; D002462:Cell Membrane / Q000821:virology; D015699:HIV Envelope Protein gp120 / Q000737:chemistry*; D015497:HIV-1 / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D008958:Models, Molecular; D010649:Phenylalanine; D011487:Protein Conformation; D019713:Receptors, CCR5 / Q000737:chemistry; D019718:Receptors, CXCR4 / Q000737:chemistry
D015704:CD4 Antigens; C527276:CXCR4 protein, human; D015699:HIV Envelope Protein gp120; D019713:Receptors, CCR5; D019718:Receptors, CXCR4; D010649:Phenylalanine