title: Induction of apoptosis in leukemic cell lines treated with captopril, trandolapril and losartan: a new role in the treatment of leukaemia for these agents.
abstract: Renin-angiotensin system (RAS) in the bone marrow is related to proliferation and cellular differentiation. We investigated the effect of ACE inhibitors (ACEI) captopril (>1mM) and trandolapril (>0.05 mM) and losartan (0.2 mM) on K562 cell line and K562 transfected with c-myc, bcl-x and bcl-2 (KmycB, Kbclx and Kbcl2 respectively). RAS components, proliferation, apoptosis and c-myc expression were analyzed. ACEI and losartan inhibited cell growth, decreased c-myc expression and increased apoptosis. These effects seem to be associated to angiotensin II-induced Smad activation. This work offers a new possible line of treatment for some acute myeloid leukemias and a new area of clinical research.
authors.affiliation: Servicio de Hematología, Hospital de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, España, Spain. siglini@gobiernodecanarias.org
authors.forename: Silvia
authors.initials: S
authors.lastname: De la Iglesia Iñigo
authors.forename: Carmen Elsa
authors.initials: CE
authors.lastname: López-Jorge
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Gómez-Casares
authors.forename: Angelina
authors.initials: A
authors.lastname: Lemes Castellano
authors.forename: Pedro
authors.initials: P
authors.lastname: Martín Cabrera
authors.forename: Jezabel
authors.initials: J
authors.lastname: López Brito
authors.forename: Alexia
authors.initials: A
authors.lastname: Suárez Cabrera
authors.forename: Teresa
authors.initials: T
authors.lastname: Molero Labarta
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D015152:Blotting, Northern; D015153:Blotting, Western; D002216:Captopril / Q000494:pharmacology*; D049109:Cell Proliferation; D016259:Genes, myc; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D020014:K562 Cells; D004915:Leukemia, Erythroblastic, Acute / Q000235:genetics / Q000473:pathology*; D019808:Losartan / Q000494:pharmacology*; D016133:Polymerase Chain Reaction
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D007211:Indoles; C052035:trandolapril; D002216:Captopril; D019808:Losartan