Pediatric antibody response to community-acquired Staphylococcus aureus infection is directed to Panton-Valentine leukocidin.
We examined the antibody responses of pediatric patients infected with community-associated Staphylococcus aureus isolates. The data show that patients infected with Panton-Valentine leukocidin (PVL)-positive strains developed a dominant immunoglobulin G anti-PVL antibody response that correlates with markers of inflammation.
Brown
Eric L
EL
Center for Infectious Disease, University of Texas School of Public Health, 1200 Herman-Pressler Dr., Houston, TX 77030, USA. eric.l.brown@uth.tmc.edu
Bowden
M Gabriela
MG
Bryson
Rebecca S
RS
Hulten
Kristina G
KG
Bordt
Andrea S
AS
Forbes
Andrea
A
Kaplan
Sheldon L
SL
D000907:Antibodies, Bacterial / Q000097:blood*; D001427:Bacterial Toxins / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000276:immunology*; D005098:Exotoxins / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007956:Leukocidins / Q000276:immunology*; D013203:Staphylococcal Infections / Q000276:immunology*; D013211:Staphylococcus aureus / Q000276:immunology*; D037521:Virulence Factors / Q000276:immunology
D000907:Antibodies, Bacterial; D001427:Bacterial Toxins; D005098:Exotoxins; D007074:Immunoglobulin G; D007956:Leukocidins; C078284:Panton-Valentine leukocidin; D037521:Virulence Factors