title: The effect of cigarette smoke exposure on developing folate binding protein-2 null mice.
abstract: Environmental tobacco smoke exposures have been linked to adverse health effects. Folate is essential for normal development, with deficiencies often causing fetal growth restriction. Mice lacking the folate binding protein-2 receptor (Folr2) exhibit increased susceptibility to teratogens. The purpose of the current study was to determine if the loss of Folr2 would increase sensitivity to cigarette smoke-induced effects on development. Pregnant Folr2(-/-), Folr2(+/+), and C57BL/6J mice were exposed to sidestream cigarette smoke during gestation. Exposure to sidestream smoke on gd 6-9 had no adverse effects on fetal outcomes. However, cigarette smoke exposure on gd 6-18.5 increased the number of fetal resorptions (Folr2(-/-) cohort) and decreased crown-rump length (Folr2(+/+) fetuses). These data confirm an association between sidestream smoke exposure and fetal growth restriction, but do not suggest that loss of Folr2 increased susceptibility to these effects.
authors.affiliation: University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, University of Louisville, ULSD, Louisville, KY 40292 (USPS); 40202 (Courier Delivery), United States.
authors.forename: Kristin H
authors.initials: KH
authors.lastname: Horn
authors.forename: Emily R
authors.initials: ER
authors.lastname: Esposito
authors.forename: Robert M
authors.initials: RM
authors.lastname: Greene
authors.forename: M Michele
authors.initials: MM
authors.lastname: Pisano
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000502:physiology*; D000013:Congenital Abnormalities / Q000209:etiology; D003367:Cotinine / Q000097:blood; D005260:Female; D047109:Fetal Development; D005327:Fetal Resorption / Q000209:etiology; D058973:Folate Receptors, GPI-Anchored; D051379:Mice; D008810:Mice, Inbred C57BL; D011247:Pregnancy; D018873:Pregnancy Rate; D011956:Receptors, Cell Surface / Q000502:physiology*; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*; D015430:Weight Gain
chemical_list: D002352:Carrier Proteins; D058973:Folate Receptors, GPI-Anchored; D011956:Receptors, Cell Surface; D014028:Tobacco Smoke Pollution; D003367:Cotinine