Invasive, paediatric, vaccine strains of Streptococcus pneumoniae: are there differences in clinical characteristics?
Invasive pneumococcal infections in 777 adults caused by 'invasive' (1, 7; n=187), 'paediatric' (6, 9, 14, 19, 23; n=304) and other (n=286) serogroups were compared. Infections caused by 'invasive' strains caused pneumonia more often than other serogroups and were more often isolated from younger patients without concomitant conditions and had lower case-fatality rate than 'paediatric' and other strains. The 2 latter groups differed little from each other. Infections caused by strains in the 7-valent pneumococcal conjugate vaccine differed little from infections caused by non-vaccine types indicating that widespread use of this vaccine will not markedly change the clinical characteristics of invasive pneumococcal infections in adults.
Trollfors
Birger
B
Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden. birger.trollfors@vgregion.se
Berg
Stefan
S
Backhaus
Erik
E
Andersson
Rune
R
Bossen Konradsen
Helle
H
D000293:Adolescent; D000328:Adult; D002648:Child; D003627:Data Interpretation, Statistical; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000382:microbiology* / Q000503:physiopathology; D022242:Pneumococcal Vaccines / Q000276:immunology; D011018:Pneumonia, Pneumococcal / Q000382:microbiology; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity*
D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022242:Pneumococcal Vaccines