New cyclic tetrapeptides from Nonomuraea sp. TA-0426 that inhibit glycine transporter type 1 (GlyT1).
In the course of our search for natural antipsychotic agents, we isolated five new cyclic tetrapeptides from the fermentation broth of Nonomuraea sp. TA-0426. These compounds turned out to be analogues of WSS2220, which had been produced by the same actinomycete and showed strong inhibitory activity against GlyT1. Four of the present peptides exhibit more potent GlyT1 inhibitory activities than WSS2220.
Terui
Yuichi
Y
Medicinal Chemistry Laboratories, Taisho Pharmaceutical Co., Ltd, 1-403 Yoshino-cho, Kita-ku, Saitama-shi, Saitama 331-9530, Japan. yuichi.terui@po.rd.taisho.co.jp
Chu
Yi-wen
YW
Li
Jun-ying
JY
Ando
Tsutomu
T
Fukunaga
Takuya
T
Aoki
Takeshi
T
Toda
Yoshihisa
Y
D000190:Actinomyces / Q000378:metabolism*; D014150:Antipsychotic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D005998:Glycine / Q000737:chemistry*; D050487:Glycine Plasma Membrane Transport Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D007532:Isoleucine / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D008956:Models, Chemical; D010455:Peptides / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013997:Time Factors
D014150:Antipsychotic Agents; D050487:Glycine Plasma Membrane Transport Proteins; D010455:Peptides; D007532:Isoleucine; D005998:Glycine