PUPylation provides the punch as Mycobacterium tuberculosis battles the host macrophage.
The proteasome machinery has been shown to provide Mycobacterium tuberculosis (Mtb) with the ability to protect itself from the damaging effects of reactive nitrogen intermediates. In their recent paper, Darwin and colleagues identify the protein modifier in Mtb that targets substrates for degradation in the Mtb proteasome.
Salgame
Padmini
P
Department of Medicine, Centre for Emerging Pathogens, UMDNJ-New Jersey Medical School, Newark, NJ 07101, USA.
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D054884:Host-Pathogen Interactions; D006801:Humans; D008264:Macrophages / Q000382:microbiology*; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex / Q000235:genetics / Q000378:metabolism; D014397:Tuberculosis, Pulmonary / Q000382:microbiology*
D001426:Bacterial Proteins; D046988:Proteasome Endopeptidase Complex