Mitosis: Cdh1 clears the way for anaphase spindle assembly.
The two co-activators of the anaphase-promoting complex/cyclosome (APC/C), Cdc20 and Cdh1, facilitate ubiquitination by the core complex, but their role in conferring substrate specificity has been contentious. A new report reveals that Cdc20-bound APC/C initiates the timely proteolysis of many Cdh1 substrates with the exception of the Aurora kinases. Failure to degrade Aurora kinases results in abnormal anaphase microtubule organisation and premature cytokinesis.
Gergely
Fanni
F
Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Department of Oncology, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK. Fanni.Gergely@cancer.org.uk
D000705:Anaphase; D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D015703:Antigens, CD; D064127:Aurora Kinases; D015820:Cadherins / Q000378:metabolism*; D064199:Cdc20 Proteins; D018797:Cell Cycle Proteins / Q000378:metabolism; D048749:Cytokinesis; D006367:HeLa Cells; D006801:Humans; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D008941:Spindle Apparatus / Q000378:metabolism*; D043743:Ubiquitin-Protein Ligase Complexes / Q000378:metabolism*
D015703:Antigens, CD; C513384:CDH1 protein, human; D015820:Cadherins; D064199:Cdc20 Proteins; D018797:Cell Cycle Proteins; C577488:CDC20 protein, human; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases