title: Adenocarcinoma in situ of the uterine cervix: a metaanalysis of 1278 patients evaluating the predictive value of conization margin status.
abstract: OBJECTIVE
  We sought to determine the value of conization margin status in predicting residual and recurrent adenocarcinoma in situ (ACIS) of the cervix.
  
  
  METHODS
  In all, 33 studies (1278 patients) were identified. Metaanalysis with pooled Mantel-Haenszel odds ratio (OR) was used to compare the risk of residual and recurrent disease according to margin status.
  
  
  RESULTS
  A repeated excisional procedure was performed in 607 patients; a positive conization margin was associated with a significant increase in the risk of residual disease (OR, 4.01; 95% confidence interval [CI], 2.62-6.33; P < .001). Of the 671 patients followed up with surveillance only, 2.6% with negative margins and 19.4% with positive margins developed a recurrence (OR, 2.48; 95% CI, 1.05-6.22; P < .001). Invasive adenocarcinoma was more commonly associated with positive margins (5.2%) compared with negative margins (0.1%).
  
  
  CONCLUSIONS
  After conization for ACIS, patients with positive margins are significantly more likely to have residual or recurrent disease, whereas those with negative margins may be treated conservatively.
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Ohio State Medical Center, Columbus, OH 43210, USA. rsalani1@jhmi.edu
authors.forename: Ritu
authors.initials: R
authors.lastname: Salani
authors.forename: Isha
authors.initials: I
authors.lastname: Puri
authors.forename: Robert E
authors.initials: RE
authors.lastname: Bristow
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery; D000328:Adult; D002278:Carcinoma in Situ / Q000473:pathology* / Q000601:surgery; D002584:Cervix Uteri / Q000473:pathology; D019092:Conization; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D018365:Neoplasm, Residual / Q000453:epidemiology*; D011237:Predictive Value of Tests; D012086:Reoperation; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery