title: The effects of ketorolac tromethamine and baicalein on the levels of inflammatory factors in human synoviocytes.
abstract: This study examined the effects of ketorolac tromethamine (KT) and baicalein (BE) on the levels of inflammatory factors in human synoviocytes. The fibroblast-like synoviocytes (FLS) cells were used to determine the possible regulatory effects of KT and BE (KTBE) on the levels of inflammatory factors in FLS cells. In addition, the levels of TNF-alpha, IL-6, and IL-1beta mRNA expression in FLS cells induced by a TNF-alpha and IL-1beta co-treatment were largely inhibited by a KTBE treatment. The level of FLS cells proliferation was increased by IL-1beta and TNF-alpha, and strongly inhibited by KTBE treatment. The production of oxygen species (ROS) was inhibited by KTBE in FLS cells. KTBE appears to regulate the levels of mRNA that are important for regulating RA progression.
authors.affiliation: Department of Pharmacy, Woosuk University, Samrye 565-701, Korea.
authors.forename: Jae-Heon
authors.initials: JH
authors.lastname: Yang
authors.forename: Mi-Young
authors.initials: MY
authors.lastname: Yun
authors.forename: Nam-Hee
authors.initials: NH
authors.lastname: Lee
authors.forename: Dae-Keun
authors.initials: DK
authors.lastname: Kim
authors.forename: Young-Il
authors.initials: YI
authors.lastname: Kim
authors.forename: Young-Hee
authors.initials: YH
authors.lastname: Noh
authors.forename: Tae-Youl
authors.initials: TY
authors.lastname: Kim
authors.forename: Se-Won
authors.initials: SW
authors.lastname: Yoon
authors.forename: Sang-Chul
authors.initials: SC
authors.lastname: Shin
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D044950:Flavanones / Q000494:pharmacology*; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D053583:Interleukin-1beta / Q000096:biosynthesis; D015850:Interleukin-6 / Q000096:biosynthesis; D020911:Ketorolac Tromethamine / Q000494:pharmacology*; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000302:isolation & purification; D017382:Reactive Oxygen Species / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013050:Spectrometry, Fluorescence; D013582:Synovial Fluid / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D044950:Flavanones; D018836:Inflammation Mediators; D053583:Interleukin-1beta; D015850:Interleukin-6; D011448:Prostaglandin Antagonists; D012333:RNA, Messenger; D017382:Reactive Oxygen Species; D014409:Tumor Necrosis Factor-alpha; C006680:baicalein; D020911:Ketorolac Tromethamine