title: Comparative cost-effectiveness of posaconazole versus fluconazole or itraconazole prophylaxis in patients with prolonged neutropenia.
abstract: OBJECTIVE
  A cost-effectiveness analysis was performed to investigate the financial impact of using posaconazole versus fluconazole or itraconazole prophylaxis in patients with prolonged neutropenia.
  
  
  METHODS
  A decision-analytic model was developed from a hospital perspective based on the use of posaconazole versus fluconazole or itraconazole prophylaxis in patients with prolonged neutropenia (i.e., longer than 7-10 days). Data reported in a multicenter study, medication-cost information, and reports of costs to treat invasive fungal infections were used to accurately populate the model. Sensitivity analyses enhanced the robustness of the model through variation of all probabilities and costs.
  
  
  RESULTS
  In the base case, patients initiated on posaconazole displayed a 45% reduction in overall cost as compared with patients initiated on fluconazole or itraconazole ($3051 versus $5529, respectively). Sensitivity analyses determined that univariate changes in all model variables, including medication cost, duration of therapy, and cost of treating invasive fungal infections, did not impact overall results. A Monte Carlo simulation analysis found that use of posaconazole remains the best overall prophylactic strategy when taking into consideration the potential variance in all model assumptions. Posaconazole dominated the use of fluconazole or itraconazole because of previously demonstrated lower incidence of breakthrough fungal infections and lower overall treatment cost.
  
  
  CONCLUSIONS
  The decision model indicated that use of posaconazole as prophylaxis in patients with prolonged neutropenia should result in lower overall treatment costs relative to the cost of fluconazole or itraconazole.
authors.affiliation: Department of Pharmacy Services, University of Michigan Health System, Ann Arbor, MI 48109, USA. cdcollin@umich.edu
authors.forename: Curtis D
authors.initials: CD
authors.lastname: Collins
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Ellis
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Kaul
mesh_terms: D000935:Antifungal Agents / Q000191:economics* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003362:Cost-Benefit Analysis; D004359:Drug Therapy, Combination; D015725:Fluconazole / Q000191:economics* / Q000627:therapeutic use; D006801:Humans; D017964:Itraconazole / Q000191:economics* / Q000627:therapeutic use; D009010:Monte Carlo Method; D015337:Multicenter Studies as Topic; D009181:Mycoses / Q000517:prevention & control*; D009503:Neutropenia / Q000139:chemically induced / Q000188:drug therapy / Q000191:economics*; D014230:Triazoles / Q000191:economics* / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; D017964:Itraconazole; C101425:posaconazole; D015725:Fluconazole