title: Impact of supplemental oxygen in mechanically ventilated adult and infant mice.
abstract: The aim of the present study was to determine the short-term effects of hyperoxia on respiratory mechanics in mechanically ventilated infant and adult mice. Eight and two week old BALB/c mice were exposed to inspired oxygen fractions [Formula: see text] of 0.21, 0.3, 0.6, and 1.0, respectively, during 120 min of mechanical ventilation. Respiratory system mechanics and inflammatory responses were measured. Using the low-frequency forced oscillation technique no differences were found in airway resistance between different [Formula: see text] groups when corrected for changes in gas viscosity. Coefficients of lung tissue damping and elastance were not different between groups and showed similar changes over time in both age groups. Inflammatory responses did not differ between groups at either age. Hyperoxia had no impact on respiratory mechanics during mechanical ventilation with low tidal volume and positive end-expiratory pressure. Hence, supplemental oxygen can safely be applied during short-term mechanical ventilation strategies in infant and adult mice.
authors.affiliation: Telethon Institute for Child Health Research, Division of Clinical Sciences, Subiaco WA 6008, Australia. vincenzoc@ichr.uwa.edu.au
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Cannizzaro
authors.forename: Luke J
authors.initials: LJ
authors.lastname: Berry
authors.forename: Graeme R
authors.initials: GR
authors.lastname: Zosky
authors.forename: Debra J
authors.initials: DJ
authors.lastname: Turner
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Hantos
authors.forename: Peter D
authors.initials: PD
authors.lastname: Sly
mesh_terms: D000367:Age Factors; D000375:Aging / Q000502:physiology*; D000403:Airway Resistance / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn; D001992:Bronchoalveolar Lavage Fluid; D054426:Chemokine CXCL2 / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D051379:Mice; D010100:Oxygen / Q000008:administration & dosage*; D010196:Pancreatic Elastase; D011175:Positive-Pressure Respiration; D001261:Pulmonary Atelectasis / Q000503:physiopathology; D012121:Respiration, Artificial; D015656:Respiratory Mechanics / Q000502:physiology*; D013990:Tidal Volume
chemical_list: D054426:Chemokine CXCL2; D007376:Interleukin-2; D010196:Pancreatic Elastase; D010100:Oxygen