Intraoperative contrast-enhanced ultrasound for brain tumors.
OBJECTIVE
The purpose of this study was to investigate the feasibility and value of the intraoperative contrast-enhanced ultrasound (CEUS) in resection for brain tumors.


METHODS
Intraoperative CEUS was performed in 29 patients with brain tumors pre-resection, in whom 9 (of 29) patients underwent second intraoperative CEUS for assessing remained tumor tissue after initial resection. Gray-scale and color-flow images of the brain tumors on both conventional and CEUS were analyzed and compared with the results of surgical pathology.


RESULTS
The border of the tumor and remained tumor tissue was more distinguishable from healthy brain on CEUS than that on conventional ultrasound during the operation. Improving definition of the tumor tissue from normal brain with CEUS was demonstrated in all cases.


CONCLUSIONS
Intraoperative CEUS has the potential to be a very useful imaging technique not only in defining the border between the tumor and healthy brain pre resection but also in detecting remained tumor tissues after the initial resection.
He
Wen
W
Department of Ultrasound, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. hewen168@sohu.com
Jiang
Xiao-qian
XQ
Wang
Shuo
S
Zhang
Mao-zhi
MZ
Zhao
Ji-zong
JZ
Liu
Hui-zhao
HZ
Ma
Jun
J
Xiang
Dong-ying
DY
Wang
Li-shu
LS
D000293:Adolescent; D000465:Algorithms; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery*; D002648:Child; D003287:Contrast Media; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008297:Male; D016343:Monitoring, Intraoperative / Q000379:methods; D010743:Phospholipids; D011379:Prognosis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013459:Sulfur Hexafluoride; D025321:Surgery, Computer-Assisted / Q000379:methods*; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional / Q000379:methods*; D055815:Young Adult
D003287:Contrast Media; D010743:Phospholipids; C420843:contrast agent BR1; D013459:Sulfur Hexafluoride