Lacticin Q, a lactococcal bacteriocin, causes high-level membrane permeability in the absence of specific receptors.
To characterize the mode of action of lacticin Q (LnqQ), its membrane-permeabilizing activity was compared with that of nisin A because of the similar antimicrobial features of these compounds. Lipid II, the receptor for nisin A, was not required for LnqQ activity. LnqQ induced high-level membrane permeability in the absence of specific receptors.
Yoneyama
Fuminori
F
Laboratory of Microbial Technology, Division of Microbial Science and Technology, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka 812-8581, Japan.
Imura
Yuichi
Y
Ichimasa
Shiro
S
Fujita
Koji
K
Zendo
Takeshi
T
Nakayama
Jiro
J
Matsuzaki
Katsumi
K
Sonomoto
Kenji
K
D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001430:Bacteriocins / Q000737:chemistry / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects*; D009561:Nisin / Q000494:pharmacology; D010539:Permeability / Q000187:drug effects*; D017433:Protein Structure, Secondary
D000900:Anti-Bacterial Agents; D001430:Bacteriocins; D009561:Nisin; C102526:nisin A