title: GammaH2AX and cancer.
abstract: Histone H2AX phosphorylation on a serine four residues from the carboxyl terminus (producing gammaH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may lead to cancer but, paradoxically, are also used to kill cancer cells. Using gammaH2AX detection to determine the extent of DSB induction may help to detect precancerous cells, to stage cancers, to monitor the effectiveness of cancer therapies and to develop novel anticancer drugs.
authors.affiliation: Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. bonnerw@mail.nih.gov
authors.forename: William M
authors.initials: WM
authors.lastname: Bonner
authors.forename: Christophe E
authors.initials: CE
authors.lastname: Redon
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Dickey
authors.forename: Asako J
authors.initials: AJ
authors.lastname: Nakamura
authors.forename: Olga A
authors.initials: OA
authors.lastname: Sedelnikova
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Solier
authors.forename: Yves
authors.initials: Y
authors.lastname: Pommier
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D053903:DNA Breaks, Double-Stranded; D004249:DNA Damage; D006657:Histones / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008322:Mammals; D051379:Mice; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology* / Q000517:prevention & control; D011230:Precancerous Conditions / Q000175:diagnosis; D011487:Protein Conformation; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction
chemical_list: D000970:Antineoplastic Agents; C468783:H2AX protein, human; D006657:Histones