Role of bile acid secretion in human colorectal cancer.
Cholic, deoxycholic and lithocholic acid promote tumor formation in the large intestine by a direct proliferative effect on rather undifferentiated mucosal epithelial cells. In addition, bile acids may play a role in colorectal cancer pathogenesis because they reduce the chemopreventive efficiency of calcium and vitamin D by interfering with calcium and vitamin D receptor-activated anti-mitogenic intracellular signalling in neoplastic colonocytes.
Peterlik
Meinrad
M
Department of Pathophysiology, Medical University of Vienna, Vienna, Austria. meinrad.peterlik@meduniwien.ac.at
D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism*; D002117:Calcitriol / Q000502:physiology*; D002118:Calcium / Q000502:physiology*; D002455:Cell Division / Q000502:physiology; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D015179:Colorectal Neoplasms / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology / Q000503:physiopathology; D051379:Mice; D018167:Receptors, Calcitriol / Q000502:physiology; D044169:Receptors, Calcium-Sensing / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
D001647:Bile Acids and Salts; D018167:Receptors, Calcitriol; D044169:Receptors, Calcium-Sensing; D002117:Calcitriol; D002118:Calcium