title: Delayed liver regeneration after partial hepatectomy in adiponectin knockout mice.
abstract: We previously demonstrated that adiponectin has anti-fibrogenic and anti-inflammatory effects in the liver of mouse models of various liver diseases. However, its role in liver regeneration remains unclear. The aim of this study was to determine the role of adiponectin in liver regeneration. We assessed liver regeneration after partial hepatectomy in wild-type (WT) and adiponectin knockout (KO) mice. We analyzed DNA replication and various signaling pathways involved in cell proliferation and metabolism. Adiponectin KO mice exhibited delayed DNA replication and increased lipid accumulation in the regenerating liver. The expression levels of peroxisome proliferator-activated receptor (PPAR) alpha and carnitine palmitoyltransferase-1 (CPT-1), a key enzyme in mitochondrial fatty acid oxidation, were decreased in adiponectin KO mice, suggesting possible contribution of altered fat metabolism to these phenomena. Collectively, the present results highlight a new role for adiponectin in the process of liver regeneration.
authors.affiliation: Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, 2-2, K1, Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: Hisao
authors.initials: H
authors.lastname: Ezaki
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Saji
authors.forename: Takayo
authors.initials: T
authors.lastname: Takemura
authors.forename: Juichi
authors.initials: J
authors.lastname: Fukushima
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Matsumoto
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kamada
authors.forename: Akira
authors.initials: A
authors.lastname: Wada
authors.forename: Takumi
authors.initials: T
authors.lastname: Igura
authors.forename: Shinji
authors.initials: S
authors.lastname: Kihara
authors.forename: Tohru
authors.initials: T
authors.lastname: Funahashi
authors.forename: Iichiro
authors.initials: I
authors.lastname: Shimomura
authors.forename: Shinji
authors.initials: S
authors.lastname: Tamura
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kiso
authors.forename: Norio
authors.initials: N
authors.lastname: Hayashi
mesh_terms: D052242:Adiponectin / Q000235:genetics / Q000502:physiology; D000818:Animals; D002334:Carnitine O-Palmitoyltransferase / Q000096:biosynthesis; D002453:Cell Cycle; D005227:Fatty Acids / Q000378:metabolism; D015870:Gene Expression; D006498:Hepatectomy; D022781:Hepatocytes / Q000166:cytology / Q000378:metabolism; D008099:Liver / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D008115:Liver Regeneration / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout; D010084:Oxidation-Reduction; D047493:PPAR alpha / Q000096:biosynthesis; D012333:RNA, Messenger / Q000096:biosynthesis; D014280:Triglycerides / Q000378:metabolism
chemical_list: D052242:Adiponectin; C499919:Adipoq protein, mouse; D005227:Fatty Acids; D047493:PPAR alpha; D012333:RNA, Messenger; D014280:Triglycerides; D002334:Carnitine O-Palmitoyltransferase