Early iron deficiency produces persistent damage to visual tracts in Wistar rats.
In this study, morphological changes in the optic nerve were determined by light microscopy in Wistar rats on an iron-deficient diet for 32 days or for 21 days followed by 10 days on an iron-recovery diet. The morphometric findings showed significantly fewer blood vessels and oligodendrocytes in the iron-deficient rats and iron-recovery rats than in the control group, as well as more astrocytes in the iron-recovery rats. Serum iron levels of the iron-deficient rats were significantly lower than those of the controls. On the other hand, iron-recovery rats had normal serum iron levels, but no change in the abnormal morphology of the myelinated axons and morphometric parameters. Our data indicate that iron is necessary for maintenance of the optic nerve cell structure, and morphological damage from iron-deficiency is not easily reverted by iron reposition.
DeMaman
Aline S
AS
Laboratory of Neuroanatomy, Department of Surgery and Anatomy, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Homem
Jefferson M
JM
Lachat
João-José
JJ
D018798:Anemia, Iron-Deficiency / Q000188:drug therapy / Q000473:pathology*; D000818:Animals; D000831:Animals, Newborn; D001253:Astrocytes / Q000473:pathology; D005260:Female; D007501:Iron / Q000008:administration & dosage / Q000097:blood; D000090463:Iron Deficiencies; D019266:Iron, Dietary / Q000008:administration & dosage; D007774:Lactation; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D009836:Oligodendroglia / Q000473:pathology; D009900:Optic Nerve / Q000098:blood supply / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar
D019266:Iron, Dietary; D007501:Iron