title: Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis.
abstract: The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 x 10(-10)). KIF1B is a neuronally expressed gene plausibly implicated in the irreversible axonal loss characterizing MS in the long term.
authors.affiliation: Genetic Epidemiology Unit, Department of Epidemiology and Biostatistics and Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Yurii S
authors.initials: YS
authors.lastname: Aulchenko
authors.forename: Ilse A
authors.initials: IA
authors.lastname: Hoppenbrouwers
authors.forename: Sreeram V
authors.initials: SV
authors.lastname: Ramagopalan
authors.forename: Linda
authors.initials: L
authors.lastname: Broer
authors.forename: Naghmeh
authors.initials: N
authors.lastname: Jafari
authors.forename: Jan
authors.initials: J
authors.lastname: Hillert
authors.forename: Jenny
authors.initials: J
authors.lastname: Link
authors.forename: Wangko
authors.initials: W
authors.lastname: Lundström
authors.forename: Eva
authors.initials: E
authors.lastname: Greiner
authors.forename: A
authors.initials: A
authors.lastname: Dessa Sadovnick
authors.forename: Dirk
authors.initials: D
authors.lastname: Goossens
authors.forename: Christine
authors.initials: C
authors.lastname: Van Broeckhoven
authors.forename: Jurgen
authors.initials: J
authors.lastname: Del-Favero
authors.forename: George C
authors.initials: GC
authors.lastname: Ebers
authors.forename: Ben A
authors.initials: BA
authors.lastname: Oostra
authors.forename: Cornelia M
authors.initials: CM
authors.lastname: van Duijn
authors.forename: Rogier Q
authors.initials: RQ
authors.lastname: Hintzen
mesh_terms: D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D007438:Introns; D016547:Kinesins / Q000235:genetics*; D009103:Multiple Sclerosis / Q000235:genetics*
chemical_list: C091053:KIF1B protein, human; D016547:Kinesins