title: Near-infrared laser computed tomography of the breast first clinical experience.
abstract: OBJECTIVE
  The purpose of the present study was to evaluate a near-infrared (NIR) laser breast imaging system (Computed Tomography Laser Mammography [CTLM]) as an adjunct to mammography by means of receiver-operating characteristic (ROC) analysis. The NIR technique used in this study is based on the absorption of NIR light by hemoglobin. Malignant tumors can be detected by imaging their neovascularization.
  
  
  METHODS
  Eighty-two patients were examined by both CTLM and mammography. Seventy-nine of the 82 patients underwent biopsies, and three patients had 2-year follow up. Three-dimensional scans were acquired with an NIR laser computed tomographic scanner (the CTLM system) at a slice thickness of 4 mm. Mammograms were analyzed alone and together with CTLM images.
  
  
  RESULTS
  Histology revealed 37 benign and 42 malignant lesions. For the combination of mammography and CTLM, the area under the ROC curve was significantly larger than for mammography alone. In addition, it was shown that the difference in area under the ROC curve between the combination of both methods and mammography alone was considerably larger for dense breasts than for radiolucent breasts, although these differences were not statistically significant.
  
  
  CONCLUSIONS
  CTLM, used as an adjunct, may serve as a feasible tool to improve the diagnostic capabilities of mammography.
authors.affiliation: Department of Radiology, Campus Charité Virchow Klinikum, Augustenburger Platz 1, D-13353 Berlin, Germany. alexander.poellinger@charite.de
authors.forename: Alexander
authors.initials: A
authors.lastname: Poellinger
authors.forename: Jan C
authors.initials: JC
authors.lastname: Martin
authors.forename: Steven L
authors.initials: SL
authors.lastname: Ponder
authors.forename: Torsten
authors.initials: T
authors.lastname: Freund
authors.forename: Bernd
authors.initials: B
authors.lastname: Hamm
authors.forename: Ulrich
authors.initials: U
authors.lastname: Bick
authors.forename: Felix
authors.initials: F
authors.lastname: Diekmann
mesh_terms: D000328:Adult; D000465:Algorithms; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007259:Infrared Rays; D007834:Lasers; D008327:Mammography / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods*; D010865:Pilot Projects; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041622:Tomography, Optical / Q000379:methods*