title: Investigation of the association between Toll-like receptor 2 gene polymorphisms and Behçet's disease in Japanese patients.
abstract: Behçet's disease (BD) is a chronic systemic inflammatory disorder characterized by recurrent ocular symptoms, oral and genital ulcers, and skin lesions. The etiology of BD is still uncertain, but genetic and environmental factors likely both play an important role in BD development. In the present study, we investigated whether polymorphisms of Toll-like receptor 2 (TLR2), previously reported to recognize BD candidate antigens, are associated with BD. Two hundred Japanese patients with BD and 128 Japanese healthy controls were recruited. We genotyped five single-nucleotide polymorphisms (SNPs) in the TLR2 gene and assessed the allele/genotype diversity between cases and controls for all SNPs. No significant differences in the frequency of TLR2 alleles, genotypes, and haplotypes in the BD cases were detected compared with the controls. These data indicate that TLR2 polymorphisms do not play an important role in the development of BD.
authors.affiliation: Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Kanagawa, Japan.
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Tomiyama
authors.forename: Akira
authors.initials: A
authors.lastname: Meguro
authors.forename: Masao
authors.initials: M
authors.lastname: Ota
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Katsuyama
authors.forename: Tadayuki
authors.initials: T
authors.lastname: Nishide
authors.forename: Riyo
authors.initials: R
authors.lastname: Uemoto
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Iijima
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Ohno
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Inoko
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Mizuki
mesh_terms: D044466:Asian People; D001528:Behcet Syndrome / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D051195:Toll-Like Receptor 2 / Q000235:genetics*
chemical_list: D051195:Toll-Like Receptor 2