Determination of the structure of the energy landscape for coarse-grained off-lattice models of folding heteropolymers.
The structure of energy landscapes for a minimalist coarse-grained off-lattice protein model is presented to investigate the folding behaviors of heteropolymers. The obtained energy landscapes serve as a useful tool for visualization of the funnel-like structure of a considered system in the configuration space. Despite the simplicity of the model, the knowledge of the free-energy landscape enables us to show different folding characteristics known from real proteins and synthetic peptides, such as two-state folding and metastability.
Arkin
Handan
H
Faculty of Engineering, Department of Physics Engineering Tandoğan, Ankara University, Ankara, Turkey. handan.olgar@eng.ankara.edu.tr
D008958:Models, Molecular; D011487:Protein Conformation; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry*
D011506:Proteins