title: Mitochondrial energetic metabolism: a simplified model of TCA cycle with ATP production.
abstract: Mitochondria play a central role in cellular energetic metabolism. The essential parts of this metabolism are the tricarboxylic acid (TCA) cycle, the respiratory chain and the adenosine triphosphate (ATP) synthesis machinery. Here a simplified model of these three metabolic components with a limited set of differential equations is presented. The existence of a steady state is demonstrated and results of numerical simulations are presented. The relevance of a simple model to represent actual in vivo behavior is discussed.
authors.affiliation: IMB UMR CNRS 5251-ESTBB, Université de Bordeaux 2, 146 rue Léo-Saignat, F 33076 Bordeaux-Cedex, France. nazaret@sm.u-bordeaux2.fr
authors.forename: Christine
authors.initials: C
authors.lastname: Nazaret
authors.forename: Margit
authors.initials: M
authors.lastname: Heiske
authors.forename: Kevin
authors.initials: K
authors.lastname: Thurley
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Mazat
mesh_terms: D000255:Adenosine Triphosphate / Q000096:biosynthesis* / Q000378:metabolism; D000818:Animals; D002952:Citric Acid Cycle / Q000502:physiology*; D003198:Computer Simulation; D004734:Energy Metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D008954:Models, Biological; D010101:Oxygen Consumption
chemical_list: D000255:Adenosine Triphosphate