Effects of dietary Korean proso-millet protein on plasma adiponectin, HDL cholesterol, insulin levels, and gene expression in obese type 2 diabetic mice.
We investigated the effect of dietary Korean proso-millet protein concentrate (PMP) on glycemic responses, plasma lipid levels, and the plasma level and gene expression of adiponectin in obese type 2 diabetic mice under normal and high-fat feeding conditions. The findings were that the feeding of PMP clearly elevated plasma high-density lipoprotein cholesterol (HDL cholesterol) and adiponectin levels and brought about effective reduction in the levels of glucose and insulin in mice under high-fat diet conditions as compared with a control diet. Gene expression study revealed that the diet up-regulated expression of adiponectin and down-regulated tumor necrosis factor-alpha (TNF-alpha). Considering the central role of adiponectin and HDL cholesterol in improving and ameliorating type 2 diabetes, obesity, and cardiovascular disease, our findings imply that PMP may have potential for therapeutic intervention in type 2 diabetes.
Park
Kyung-Ok
KO
United Graduate School of Agricultural Sciences, Iwate University, Japan.
Ito
Yoshiaki
Y
Nagasawa
Takashi
T
Choi
Myeong-Rak
MR
Nishizawa
Naoyuki
N
D052242:Adiponectin / Q000097:blood*; D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D004041:Dietary Fats / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects*; D007328:Insulin / Q000097:blood*; D007723:Korea; D050356:Lipid Metabolism / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008820:Mice, Obese; D008897:Panicum / Q000737:chemistry*; D014674:Plant Proteins, Dietary / Q000737:chemistry / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D015430:Weight Gain / Q000187:drug effects
D052242:Adiponectin; D001786:Blood Glucose; D008076:Cholesterol, HDL; D004041:Dietary Fats; D007328:Insulin; D014674:Plant Proteins, Dietary; D014409:Tumor Necrosis Factor-alpha