title: Development of solid-phase microextraction followed by gas chromatography-mass spectrometry for rapid analysis of volatile organic chemicals in mainstream cigarette smoke.
abstract: In this work, a novel, simple and efficient method based on solid-phase microextraction (SPME) followed by gas chromatography-mass spectrometry (GC-MS) was developed to the analysis of volatile organic chemicals (VOCs) in mainstream cigarette smoke (MCS). Using a simple home-made smoking machine device, extraction and concentration of VOCs in MCS were performed by SPME fiber, and the VOCs adsorbed on fiber were desorbed, and analyzed by GC-MS. The extraction fiber types and the desorption conditions were studied, and the method precision was also investigated. After the investigation, the optimal fiber was divinylbenzene/carboxen/polydemethylsiloxane (DVB/CAR/PDMS), and the optimal desorption condition was 250 degrees C for 3 min. The method precision was from 2% to 11%. Finally, the proposed method was tested by its application of the analysis of VOCs in MCS from 10 brands of cigarettes and one reference cigarette. A total of 70 volatile compounds were identified by the proposed method. The experimental results showed that the proposed method was a simple, rapid, reliable, and solvent-free technique for the determination of VOCs in MCS.
authors.affiliation: Department of Chemistry, Shangrao Normal University, Shangrao 334001, Province of Jiangxi, China. sryq6333@163.com
authors.forename: Qing
authors.initials: Q
authors.lastname: Ye
mesh_terms: D016902:Air Pollution, Indoor / Q000032:analysis; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D012906:Smoke / Q000032:analysis; D052617:Solid Phase Microextraction / Q000379:methods; D014026:Nicotiana / Q000737:chemistry*; D055549:Volatile Organic Compounds / Q000032:analysis*
chemical_list: D012906:Smoke; D055549:Volatile Organic Compounds