title: Magnetocardiography based spatiotemporal correlation analysis is superior to conventional ECG analysis for identifying myocardial injury.
abstract: Electrocardiogram (ECG) particular from tiny, non Q-wave myocardial infarction may lack striking infarct pattern. Spatiotemporal correlation analysis (SCA) of multichannel magnetocardiogram (MCG) is a high-resolution "magnifying glass" to analyze homogeneity of repolarization. SCA involves full 4D spatiotemporal information to identify abnormalities as empirically done by eye in conventional ECG-but on an advanced level of analysis. We compared the discriminatory performance of SCA to ECG analysis in identifying myocardial infarction. Eleven SCA parameters were taken from signal averaged 31-channel MCG and compared to infarct indicators of ECG's in 178 subjects: 108 patients (76 males, mean age 62 years) after myocardial infarction (16-64 d) and 70 controls (36 males, mean age 46 years). SCA improves the detection of myocardial injury: in 72.5% ECG (sensitivity 68.6%, specificity 56%) and in 80.2% SCA parameters (sensitivity 72.6%, specificity 64%) separated patients from controls. SCA is applicable for the analysis of de- and repolarization of cardiac mapping data.
authors.affiliation: Clinic of Internal Medicine I, Friedrich-Schiller-University Jena, Jena, Germany. Matthias.Goernig@med.uni-jena.de
authors.forename: Matthias
authors.initials: M
authors.lastname: Goernig
authors.forename: Mario
authors.initials: M
authors.lastname: Liehr
authors.forename: Christian
authors.initials: C
authors.lastname: Tute
authors.forename: Markus
authors.initials: M
authors.lastname: Schlosser
authors.forename: Jens
authors.initials: J
authors.lastname: Haueisen
authors.forename: H R
authors.initials: HR
authors.lastname: Figulla
authors.forename: U
authors.initials: U
authors.lastname: Leder
mesh_terms: D004562:Electrocardiography / Q000379:methods; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans; D053798:Magnetocardiography / Q000379:methods; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000503:physiopathology; D012815:Signal Processing, Computer-Assisted