title: A Zinc(II)/poly(gamma-glutamic acid) complex as an oral therapeutic for the treatment of type-2 diabetic KKAy mice.
abstract: In developing new insulin-mimetic zinc(II) complexes with various ligands including a biodegradable polymer, we prepared and characterized a Zn(gamma-pga) complex in solution as well as in solid, and investigated its in vitro insulin-mimetic activity and in vivo antidiabetic effect in type-2 diabetic KKA(y) mice. The in vitro insulin-mimetic activity of the Zn(gamma-pga) complex was considerable better than that of ZnSO(4). The Zn(gamma-pga) complex normalized the hyperglycemia in KKA(y) mice within 21 d when administrated orally at doses of 10-20 mg (0.15-0.31 mmol) Zn per kg body mass for 30 d. In addition, the impaired glucose tolerance, elevated HbA(1c) levels and metabolic syndromes were significantly improved in Zn(gamma-pga)-treated KKA(y) mice relative to those administrated with saline and ZnSO(4).
authors.affiliation: Department of Chemistry, Primeasia University, HBR Tower, 9 Banani C/A, Dhaka-1213, Bangladesh.
authors.forename: Subarna
authors.initials: S
authors.lastname: Karmaker
authors.forename: Tapan K
authors.initials: TK
authors.lastname: Saha
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yoshikawa
authors.forename: Hiromu
authors.initials: H
authors.lastname: Sakurai
mesh_terms: D000284:Administration, Oral; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D006943:Hyperglycemia / Q000188:drug therapy; D007328:Insulin; D051379:Mice; D008815:Mice, Inbred Strains; D018716:Molecular Mimicry; D011099:Polyglutamic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016896:Treatment Outcome; D015032:Zinc
chemical_list: D007328:Insulin; C511775:poly(gamma-glutamic acid); D011099:Polyglutamic Acid; D015032:Zinc