title: Treatment of low-grade bulbar transitional cell carcinoma with urethral instillation of mitomycin C.
abstract: A 63-year old man was referred to us after three rapid recurrences of low-grade urethral papillary transitional cell carcinoma of the bulbar urethra, after repeated primary excision. Cystoscopy confirmed 3-4 low-grade urethral transitional cell carcinomas, which were subsequently fulgurated. After urethral healing, a solution of Mitomycin C (40 mg/80 cc) was instilled into the urethra for fifteen minutes and held in place with a penile clamp. Urethral instillations were repeated weekly for six weeks. The patient is currently disease-free more than one year and three months posttreatment. This case highlights the successful treatment of urethral carcinoma with topical chemotherapy, which is usually reserved for the bladder, using a slight modification of standard technique.
authors.affiliation: School of Medicine, Wayne State University, Detroit, MI 48201, USA.
authors.forename: Emmanuel J
authors.initials: EJ
authors.lastname: Melonakos
authors.forename: Richard A
authors.initials: RA
authors.lastname: Santucci