title: Molecular targets and biological modifiers in gastric cancer.
abstract: The overall survival of gastric cancer patients remains poor despite efforts and advances in its prevention, diagnosis, and treatment. The development of new therapies is crucial for the effective control of this disease. An increasing number of genetic and epigenetic alterations have been associated with distinct histological types of gastric cancer. In this review, we will discuss the involvement of E-cadherin, EGFR, ERBB2, MMR genes, KRAS, and PIK3CA in the development and progression of gastric cancer and their role as biomarkers or as novel putative targets for therapy.
authors.affiliation: Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal. fcarneiro@ipatimup.pt
authors.forename: Fátima
authors.initials: F
authors.lastname: Carneiro
authors.forename: Carla
authors.initials: C
authors.lastname: Oliveira
authors.forename: Marina
authors.initials: M
authors.lastname: Leite
authors.forename: Raquel
authors.initials: R
authors.lastname: Seruca
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D014408:Biomarkers, Tumor / Q000235:genetics*; D016503:Drug Delivery Systems / Q000379:methods / Q000639:trends*; D006801:Humans; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000235:genetics*
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor