Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis.
The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 x 10(-10)). KIF1B is a neuronally expressed gene plausibly implicated in the irreversible axonal loss characterizing MS in the long term.
Aulchenko
Yurii S
YS
Genetic Epidemiology Unit, Department of Epidemiology and Biostatistics and Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands.
Hoppenbrouwers
Ilse A
IA
Ramagopalan
Sreeram V
SV
Broer
Linda
L
Jafari
Naghmeh
N
Hillert
Jan
J
Link
Jenny
J
Lundström
Wangko
W
Greiner
Eva
E
Dessa Sadovnick
A
A
Goossens
Dirk
D
Van Broeckhoven
Christine
C
Del-Favero
Jurgen
J
Ebers
George C
GC
Oostra
Ben A
BA
van Duijn
Cornelia M
CM
Hintzen
Rogier Q
RQ
D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D007438:Introns; D016547:Kinesins / Q000235:genetics*; D009103:Multiple Sclerosis / Q000235:genetics*
C091053:KIF1B protein, human; D016547:Kinesins