Biomarkers of Th2 polarity are predictive of staphylococcal colonization in subjects with atopic dermatitis.
BACKGROUND
Staphylococcal colonization of the skin is commonly observed in subjects with atopic dermatitis (AD) and correlates with disease severity. Little is known about whether the degree of T-helper 2 (Th2) polarity in these subjects can also affect the frequency of bacterial colonization in this disease.


OBJECTIVE
To determine if there is a correlation between markers of Th2 polarity [serum total IgE, eosinophilia and presence of another atopic disease (allergic rhinitis)] and skin colonization with Staphylococcus aureus in subjects with AD.


METHODS
A retrospective chart review was performed of an academic dermatology clinic focused on the treatment of AD with a single provider.


RESULTS
Staphylococcus aureus colonization was more commonly observed in subjects with AD who had peripheral eosinophilia, elevated serum IgE levels, and/or a history of or active allergic rhinitis.


CONCLUSIONS
Results suggest that Th2 polarity may enhance subjects' risk for bacterial colonization.
Warner
J A
JA
Department of Dermatology, Johns Hopkins Medical Institution, Baltimore, MD 21224, USA.
McGirt
L Y
LY
Beck
L A
LA
D000328:Adult; D015415:Biomarkers / Q000097:blood; D016764:Cell Polarity; D003876:Dermatitis, Atopic / Q000276:immunology* / Q000382:microbiology; D004802:Eosinophilia / Q000276:immunology; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D012189:Retrospective Studies; D012720:Severity of Illness Index; D012867:Skin / Q000382:microbiology*; D013207:Staphylococcal Skin Infections / Q000276:immunology* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000302:isolation & purification; D018418:Th2 Cells / Q000276:immunology*
D015415:Biomarkers; D007073:Immunoglobulin E