title: In-vivo singlet oxygen dosimetry of clinical 5-aminolevulinic acid photodynamic therapy.
abstract: Photodynamic therapy (PDT) is a viable treatment option for a wide range of applications, including oncology, dermatology, and ophthalmology. Singlet oxygen is believed to play a key role in the efficacy of PDT, and on-line monitoring of singlet oxygen during PDT could provide a methodology to establish and customize the treatment dose clinically. This work is the first report of monitoring singlet oxygen luminescence in vivo in human subjects during PDT, demonstrating the correlation of singlet oxygen levels during PDT with the post-PDT photobiological response.
authors.affiliation: Massachusetts General Hospital, Wellman Center for Photomedicine, Boston, Massachusetts 02114, USA.
authors.forename: Hans-Joachim
authors.initials: HJ
authors.lastname: Laubach
authors.forename: Sung K
authors.initials: SK
authors.lastname: Chang
authors.forename: Seonkyung
authors.initials: S
authors.lastname: Lee
authors.forename: Imran
authors.initials: I
authors.lastname: Rizvi
authors.forename: David
authors.initials: D
authors.lastname: Zurakowski
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Davis
authors.forename: Charles R
authors.initials: CR
authors.lastname: Taylor
authors.forename: Tayyaba
authors.initials: T
authors.lastname: Hasan
mesh_terms: D000622:Aminolevulinic Acid / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008163:Luminescent Measurements / Q000379:methods*; D008297:Male; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage; D011874:Radiometry / Q000379:methods*; D026082:Singlet Oxygen / Q000032:analysis*; D012867:Skin / Q000187:drug effects* / Q000378:metabolism*
chemical_list: D017319:Photosensitizing Agents; D026082:Singlet Oxygen; D000622:Aminolevulinic Acid