title: A systematic review of medication safety and clinical outcomes related to drug interaction software.
abstract: We conducted a systematic search of MEDLINE, EMBASE, IPA, HealthStar and CINAHL, for English language, post-1990, prospective studies examining electronic drug interaction checking (eDIC) on the outcome of adverse drug interactions (ADI). Excluded studies were not prospective or measured non-patient specific outcomes. Four of 5848 studies were included. Bayesian pooled meta-analysis showed no difference in ADIs (relative risk is 0.66, 95% CI 0.33 to 1.18.). Not only is there a lack of rigorous evaluations of eDIC, the evidence available does not suggest benefit even for the surrogate outcome of adverse drug interactions.
authors.affiliation: Centre for Evaluation of Medicines, Hamilton, ON; Faculty of Pharmaceutical Sciences, University of Toronto, Toronto, ON.
authors.forename: Kevin
authors.initials: K
authors.lastname: Wong
authors.forename: Savio
authors.initials: S
authors.lastname: Yu
authors.forename: Anne
authors.initials: A
authors.lastname: Holbrook
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems / Q000706:statistics & numerical data*; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology* / Q000517:prevention & control*; D019317:Evidence-Based Medicine / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D017063:Outcome Assessment, Health Care; D010506:Periodicals as Topic / Q000706:statistics & numerical data*