title: Risk factors of surgical site infection after hepatectomy for liver cancers.
abstract: BACKGROUND
  Risk factors of surgical site infection (SSI) after hepatectomy under the guideline of Centers for Disease Control and Prevention (CDC) are not well examined.
  
  
  METHODS
  Hospital records of consecutive patients who underwent hepatectomy without biliary reconstruction for liver cancers were reviewed retrospectively. Prophylactic antibiotics were given to patients just before skin incision and every 3 hours during the operations. Clinicopathological factors were compared between patients who developed SSI and those without it.
  
  
  RESULTS
  There were 405 patients identified, and the incidence of SSI was 23 cases (5.8%). In multivariate analysis, intraoperative bowel injury, blood loss >2000 ml, and age older than 65 years were significant risk factors of SSI after hepatectomy.
  
  
  CONCLUSIONS
  Prophylactic antibiotics were necessary only during the operation for most patients who underwent hepatectomy without biliary reconstruction. However, patients with intraoperative bowel injury, blood loss >2000 ml, and age older than 65 years are at risk to develop SSI and might need additional administration of prophylactic antibiotics after surgery.
authors.affiliation: National Cancer Center East Hospital, 6-5-1, Chiba, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan. shkobaya@east.ncc.go.jp
authors.forename: Shin
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Naoto
authors.initials: N
authors.lastname: Gotohda
authors.forename: Toshio
authors.initials: T
authors.lastname: Nakagohri
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Takahashi
authors.forename: Masaru
authors.initials: M
authors.lastname: Konishi
authors.forename: Taira
authors.initials: T
authors.lastname: Kinoshita
mesh_terms: D000367:Age Factors; D000368:Aged; D019072:Antibiotic Prophylaxis; D016063:Blood Loss, Surgical; D005260:Female; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008113:Liver Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D013530:Surgical Wound Infection / Q000453:epidemiology* / Q000517:prevention & control