An organocatalytic approach to the construction of chiral oxazolidinone rings and application in the synthesis of antibiotic linezolid and its analogues.
An efficient, catalytic asymmetric approach to antibacterial agent linezolid has been developed. The route features organocatalytic, highly enantioselective aldol and Beckman rearrangement reactions. The strategy has also been successfully applied for the preparation of new alpha-substituted analogues with high enantio- and diastereoselectivity.
Song
Lirong
L
Department of Pharmaceutical Sciences, School of Pharmacy, East China University of Science & Technology, Shanghai 200237, People's Republic of China.
Chen
Xiaobei
X
Zhang
Shilei
S
Zhang
Haoyi
H
Li
Ping
P
Luo
Guangshun
G
Liu
Wenjing
W
Duan
Wenhu
W
Wang
Wei
W
D000081:Acetamides / Q000138:chemical synthesis* / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D000069349:Linezolid; D023303:Oxazolidinones / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid