Sudden cardiac death in a young HIV-positive man on effective antiretroviral therapy.
We describe the case of a young HIV-positive man on effective HAART with excellent viro-immunological control who presented a massive cardiac infarction. Despite the presence of clinical risk factors for cardiovascular disease, the patient had normal arterial carotid IMT values, known to be strong predictors of atherosclerosis and stroke. Interestingly, parameters of T-cell activation (CD8+CD38+) were shown to increase just before the onset of myocardial infarction. As T-cell activation is known to mediate atherosclerosis, the authors suggest that surrogate immunologic markers should be identified to better assess cardiovascular risk in the setting of HIV infection.
Tincati
Camilla
C
Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases and Tropical Medicine, San Paolo Hospital, University of Milan, Italy. camilla.tincati@gmail.com
Bauer
Dario
D
Bellistrì
Giusi M
GM
Casana
Maddalena
M
Ranieri
Roberto
R
Bini
Teresa
T
Marchetti
Giulia
G
d'Arminio Monforte
Antonella
A
D051997:ADP-ribosyl Cyclase 1 / Q000032:analysis; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D018414:CD8-Positive T-Lymphocytes / Q000737:chemistry / Q000276:immunology; D016757:Death, Sudden, Cardiac; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D008297:Male
D051997:ADP-ribosyl Cyclase 1