Synergistic effect of three benzopyrans isolated from Hypericum polyanthemum in U-373 MG glioblastoma cell line.
The antiproliferative activity of three benzopyrans isolated from the chloroform extract of the aerial parts of Hypericum polyanthemum was analysed in order to determine their effect on the growth and cell cycle in the U-373 MG glioblastoma cell line. Compound 1 was less cytotoxic than compounds 2 and 3. A synergistic effect was noticed when the three benzopyrans were used simultaneously. The cytotoxicity noted could be related to an arrest in G2/M phase, leading to apoptosis in the U-373 MG glioblastoma cell line.
Grivicich
Ivana
I
Laboratório de Marcadores de Estresse Celular, Centro de Pesquisas em Ciências Médicas, Universidade Luterana do Brasil, Canoas, RS, Brazil. grivicich@terra.com.br
Ferraz
Alexandre
A
Faria
Denise H
DH
Regner
Andréa
A
Schwartsmann
Gilberto
G
Henriques
Amelia T
AT
von Poser
Gilsane L
GL
da Rocha
Adriana B
AB
D000704:Analysis of Variance; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D001578:Benzopyrans / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D004357:Drug Synergism; D006801:Humans; D020902:Hypericum / Q000737:chemistry*; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D001578:Benzopyrans; D010936:Plant Extracts