title: [Effect of perindopril on cognitive functions in young and middle aged patients with hypertensive disease].
abstract: We studied 40 men aged 26 - 59 years (mean age 49.0 +/- 1.9 years) with hypertensive disease (HD) and found that therapy based on the use of angiotensin converting enzyme inhibitor perindopril in young and middle aged patients with stage I and II HD appeared to be not only one of effective methods of correction of elevated arterial pressure (AP) but also of associated with it cognitive abnormalities. Effect of therapy was determined by achievement of target AP values and was more pronounced in patients older than 44 years. Favorable effects of perindopril in relation to parameters of cognitive functions in patients with HD allows to rate perindopril not only as effective and safe hypotensive preparation but as remedy exerting cerebroprotective effect.
authors.forename: S A
authors.initials: SA
authors.lastname: Smakotina
authors.forename: O A
authors.initials: OA
authors.lastname: Trubnikova
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Anan'ko
authors.forename: O L
authors.initials: OL
authors.lastname: Barbarash
mesh_terms: D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D018660:Blood Pressure Monitoring, Ambulatory; D003071:Cognition / Q000187:drug effects* / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D020913:Perindopril / Q000627:therapeutic use*; D011594:Psychometrics / Q000379:methods; D016896:Treatment Outcome
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D020913:Perindopril