title: The serotonin transporter 5-HTTPR polymorphism is associated with current and lifetime depression in persons with chronic psychotic disorders.
abstract: OBJECTIVE
  Variation in the serotonin transporter gene (SLC6A4) promoter region has been shown to influence depression in persons who have been exposed to a number of stressful life events.
  
  
  METHODS
  We evaluated whether genetic variation in 5-HTTLPR, influences current depression, lifetime history of depression and quantitative measures of depression in persons with chronic psychotic disorders. This is an association study of a genetic variant with quantitative and categorical definitions of depression conducted in the southwest US, Mexico and Costa Rica. We analyzed 260 subjects with a history of psychosis, from a sample of 129 families.
  
  
  RESULTS
  We found that persons carrying at least one short allele had a statistically significant increased lifetime risk for depressive syndromes (P < 0.02, odds ratio 2.18, 95% CI 1.10-4.20).
  
  
  CONCLUSIONS
  The 'ss' or 'sl' genotype at the 5-HTTLPR promoter polymorphic locus increases the risk of psychotic individuals to develop major depression during the course of their illness.
authors.affiliation: Department of Psychiatry, Psychiatric Genetics Research Center, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
authors.forename: J
authors.initials: J
authors.lastname: Contreras
authors.forename: L
authors.initials: L
authors.lastname: Hare
authors.forename: B
authors.initials: B
authors.lastname: Camarena
authors.forename: D
authors.initials: D
authors.lastname: Glahn
authors.forename: A
authors.initials: A
authors.lastname: Dassori
authors.forename: R
authors.initials: R
authors.lastname: Medina
authors.forename: S
authors.initials: S
authors.lastname: Contreras
authors.forename: M
authors.initials: M
authors.lastname: Ramirez
authors.forename: R
authors.initials: R
authors.lastname: Armas
authors.forename: R
authors.initials: R
authors.lastname: Munoz
authors.forename: R
authors.initials: R
authors.lastname: Mendoza
authors.forename: H
authors.initials: H
authors.lastname: Raventos
authors.forename: A
authors.initials: A
authors.lastname: Ontiveros
authors.forename: H
authors.initials: H
authors.lastname: Nicolini
authors.forename: R
authors.initials: R
authors.lastname: Palmer
authors.forename: M
authors.initials: M
authors.lastname: Escamilla
mesh_terms: D000328:Adult; D000483:Alleles; D002908:Chronic Disease; D015897:Comorbidity; D003364:Costa Rica / Q000453:epidemiology; D003866:Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D011618:Psychotic Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D012307:Risk Factors; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D012720:Severity of Illness Index; D013995:Time; D014481:United States / Q000453:epidemiology
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins