Altered functioning of the executive control circuit in late-life depression: episodic and persistent phenomena.
OBJECTIVE
To characterize the functional neuroanatomy of late-life depression (LLD) by probing for both episodic and persistent alterations in the executive-control circuit of elderly adults.


METHODS
Event-related functional magnetic resonance imaging (fMRI) data were collected while participants performed an executive-control task.


METHODS
Participants were recruited through a depression-treatment study within the Pittsburgh, PA, Intervention Research Center for Late-Life Mood Disorders.


METHODS
Thirteen nondepressed elderly comparison participants and 13 LLD patients.


METHODS
The depressed patients underwent imaging before initiating and after completing 12 weeks of paroxetine.


METHODS
Regional fMRI activity was assessed in the dorsolateral prefrontal cortex (dLPFC: BA9 and BA46 bilaterally) and the dorsal anterior cingulate cortex (dACC). Functional connectivity was assessed by correlating the fMRI time-series in the dLPFC and dACC.


RESULTS
Both depressed and comparison participants performed the task as expected, with greater response latency during high versus low-load trials. The response-latency load-effect did not differ between groups. In contrast to the null findings for behavioral data, pretreatment, depressed patients showed diminished activity in the dLPFC (BA46 left, t(25)=1.9, p = 0.035) and diminished functional connectivity between the dLPFC and dACC. Moreover, right dLPFC (BA46 right, t(25)=2.17, p < 0.02) showed increased activity after treatment.


CONCLUSIONS
These results support a model of both episodic and persistent neurobiologic components of LLD. The altered functional connectivity,perhaps due to vascular damage to frontal white matter, appears to be persistent. Further, at least some of the prefrontal hypoactivity (in the right dLPFC) seems to be an episodic characteristic of acute depression amenable to treatment.
Aizenstein
Howard J
HJ
Department of Psychiatry, University of Pittsburgh, and Western Psychiatric Institute and Clinic, 3811 O'Hara Street, Pittsburgh, PA 15213, USA. aizen@pitt.edu
Butters
Meryl A
MA
Wu
Minjie
M
Mazurkewicz
Laura M
LM
Stenger
V Andrew
VA
Gianaros
Peter J
PJ
Becker
James T
JT
Reynolds
Charles F
CF
Carter
Cameron S
CS
D017668:Age of Onset; D000368:Aged; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use; D003071:Cognition / Q000502:physiology; D003866:Depressive Disorder / Q000188:drug therapy / Q000503:physiopathology*; D006179:Gyrus Cinguli / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009482:Neurophysiology; D009483:Neuropsychological Tests; D017374:Paroxetine / Q000627:therapeutic use; D017397:Prefrontal Cortex / Q000503:physiopathology*; D011930:Reaction Time
D018687:Antidepressive Agents, Second-Generation; D017374:Paroxetine