title: Comparison of current density viability imaging at rest with FDG-PET in patients after myocardial infarction.
abstract: The assessment of myocardial viability is a major diagnostic challenge in patients with coronary artery disease (CAD) after myocardial infarction. Novel threedimensional current density (CD) imaging algorithms use high-resolution magnetic field mapping to determine the electrical activity of myocardial segments at rest. We, for the first time, compared CD activity obtained with several algorithms to 18-F-fluoro-deoxyglucose positron emission tomography (FDG-PET) in evaluation of myocardial viability. Magnetic field maps were obtained in nine adult patients (pt) with CAD and a history of infarction. The criterion for non-viable myocardium was an FDG-PET uptake with less than 45% of the maximum in the respective segments. CD imaging was applied to the left ventricle by using six different methods to solve the inverse problem. Mean CD activity was calculated for a close meshed grid of 90 locations of the left ventricle. A cardiologist compared bull's eye plots of CD and FDG-PET activity by eye. Spearman's correlation coefficients and specificity at a given level of sensitivity (70%) were calculated. Bull's eye plots revealed a significant correlation of CD/PET in 5 pt and no correlation in 3 pt. One pt had a negative correlation. The six different CD reconstruction methods performed similar. While CD reconstruction has the principal potential to image viable myocardium, we found that the reconstructed CD magnitude was low in scar segments but also reduced in some segments with preserved metabolic activity under resting conditions. New vector measurement techniques, the use of additional stress testing and advances in mathematical methodology are expected to improve CD imaging in future.
authors.affiliation: Clinic of Internal Medicine I, University Hospital of Jena, Erlanger Allee 101, 07747 Jena, Germany. Matthias.Goernig@med.uni-jena.de
authors.forename: M
authors.initials: M
authors.lastname: Goernig
authors.forename: J
authors.initials: J
authors.lastname: Haueisen
authors.forename: J
authors.initials: J
authors.lastname: Schreiber
authors.forename: U
authors.initials: U
authors.lastname: Leder
authors.forename: H
authors.initials: H
authors.lastname: Hänninen
authors.forename: T
authors.initials: T
authors.lastname: Mäkelä
authors.forename: P
authors.initials: P
authors.lastname: Takala
authors.forename: J
authors.initials: J
authors.lastname: Nenonen
authors.forename: K
authors.initials: K
authors.lastname: Lauerma
authors.forename: J
authors.initials: J
authors.lastname: Knuuti
authors.forename: M
authors.initials: M
authors.lastname: Mäkijärvi
authors.forename: L
authors.initials: L
authors.lastname: Toivonen
authors.forename: T
authors.initials: T
authors.lastname: Katila
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging*; D055590:Electromagnetic Phenomena; D005260:Female; D019788:Fluorodeoxyglucose F18; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D053798:Magnetocardiography / Q000379:methods*; D008297:Male; D009203:Myocardial Infarction / Q000150:complications / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography / Q000379:methods*; D012146:Rest
chemical_list: D019788:Fluorodeoxyglucose F18