[Hypersensitivity pneumonitis due to venlafaxine].
Venlafaxine is a selective serotonin, noradrenalin, and dopamine reuptake inhibitor. Although side effects are rare, venlafaxine has very occasionally been associated with hypersensitivity pneumonitis. We report the case of a 61-year-old woman diagnosed with depressive disorder and treated with venlafaxine (Dobupal) at a dose of 150 mg/d for 18 months. When depression worsened, the dose was increased to 255 mg/d. Three weeks later she complained of nonproductive cough, shortness of breath with moderate effort, and asthenia. Clinical and radiologic findings, lung function, bronchoalveolar lavage, and histology of lung biopsies all indicated a diagnosis of hypersensitivity pneumonitis. Other causes were ruled out and venlafaxine was discontinued. Clinical, radiologic, and lung function findings then resolved without the use of corticosteroids or nonsteroid immune modulators. All findings were normal on follow-up after 3 months.
Borderías Clau
Luis
L
Sección de Neumología, Hospital General San Jorge, Huesca, España. lborderias@separ.es
Marigil Gómez
Miguel Angel
MA
Val Adán
Pascual
P
Marcén Letosa
Mariano
M
Biescas López
Rosa
R
Garrapiz López
Francisco J
FJ
D000542:Alveolitis, Extrinsic Allergic / Q000139:chemically induced*; D003511:Cyclohexanols / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*; D000069470:Venlafaxine Hydrochloride
D003511:Cyclohexanols; D017367:Selective Serotonin Reuptake Inhibitors; D000069470:Venlafaxine Hydrochloride