Iatrogenic Cushing syndrome after epidural triamcinolone injections in an HIV type 1-infected patient receiving therapy with ritonavir-lopinavir.
We report the first case of a human immunodeficiency virus type 1 (HIV-1)-infected individual receiving combination antiretroviral therapy, which included ritonavir, who developed Cushing syndrome with profound complications after epidural triamcinolone injections. This case highlights the potential of ritonavir interactions even with local injections of a corticosteroid.
Ramanathan
Roshan
R
Clinical Parasitology Unit and Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. ramanathanr@niaid.nih.gov
Pau
Alice K
AK
Busse
Kristin H
KH
Zemskova
Marina
M
Nieman
Lynnette
L
Kwan
Richard
R
Hammer
Jean H
JH
Mican
JoAnn M
JM
Maldarelli
Frank
F
D000328:Adult; D003480:Cushing Syndrome; D004347:Drug Interactions; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D015497:HIV-1 / Q000302:isolation & purification; D006801:Humans; D007049:Iatrogenic Disease; D061466:Lopinavir; D008297:Male; D011744:Pyrimidinones / Q000627:therapeutic use*; D019438:Ritonavir / Q000627:therapeutic use*; D014221:Triamcinolone / Q000008:administration & dosage* / Q000009:adverse effects*
D011744:Pyrimidinones; D014221:Triamcinolone; D061466:Lopinavir; D019438:Ritonavir