title: Mycophenolic derivatives from Eupenicillium parvum.
abstract: A new compound, euparvic acid (1, C(14)H(16)O(6)), and the known compounds 5,7-dihydroxy-4-methylphthalide (2), 6-(3-carboxybutyl)-7-hydroxy-5-methoxy-4-methylphthalan-1-one (3), 6-(5-carboxy-3-methylpent-2-enyl)-7-hydroxy-5-methoxy-4-methylphthalan-1-one (4), and 6-(5-carboxy-4-hydroxy-3-methylpent-2-enyl)-7-hydroxy-5-methoxy-4-methylphthalan-1-one (5) were isolated from the EtOAc extract of Eupenicillium parvum. The structure of 1 was determined by interpretation of MS and homo- and heteronuclear 2D NMR spectroscopic data and confirmed by X-ray crystallography. The absolute configuration of 5 was determined via MPA ester derivatization.
authors.affiliation: National Center for Natural Products Research and Department of Medicinal Chemistry, School of Pharmacy, University of Mississippi, University, Mississippi 38677, USA.
authors.forename: Eman
authors.initials: E
authors.lastname: Habib
authors.forename: Francisco
authors.initials: F
authors.lastname: León
authors.forename: John D
authors.initials: JD
authors.lastname: Bauer
authors.forename: Robert A
authors.initials: RA
authors.lastname: Hill
authors.forename: Paulo
authors.initials: P
authors.lastname: Carvalho
authors.forename: Horace G
authors.initials: HG
authors.lastname: Cutler
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Cutler
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D018360:Crystallography, X-Ray; D004926:Escherichia coli / Q000187:drug effects; D055324:Eupenicillium / Q000737:chemistry*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification; D011550:Pseudomonas aeruginosa / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; C567996:euparvic acid; D009173:Mycophenolic Acid