[Effect of extracellular calcium on intrinsically bursting neurons in the entorhinal cortex of newborn rats: the computer modeling study].
In the developing rat entorhinal cortex principal neurons generated prolonged calcium-dependent intrinsic bursting activity, which was strongly increased by a reduction of extracellular Ca2+ concentration ([Ca2+]ex) from 2 to 1 mM. We suggest that enhancement of persistent sodium current (I(NaP)) after lowering of [Ca2+]ex might be a critical factof for the phenomenon. Computational modeling of prolonged neuronal bursting activity supports our proposal.
Sherozia
M G
MG
Egorov
A V
AV
D000818:Animals; D000831:Animals, Newborn; D002118:Calcium / Q000502:physiology*; D003198:Computer Simulation; D018728:Entorhinal Cortex / Q000502:physiology*; D005110:Extracellular Space / Q000502:physiology*; D008564:Membrane Potentials; D008954:Models, Biological; D009474:Neurons / Q000502:physiology*; D051381:Rats
D002118:Calcium