Oxidative stress and inflammatory markers in normal pregnancy and preeclampsia.
OBJECTIVE
Although previous investigators have demonstrated the presence of oxidative stress and inflammation in preeclampsia, none directly correlate both to preeclampsia.


METHODS
We determined in 35 preeclamptic and 35 normotensive pregnant women plasma levels of thiobarbituric acid reactive species, protein carbonyl, tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6 and IL-10.


RESULTS
Plasma thiobarbituric acid reactive species and protein carbonyls were higher in preeclamptic patients. TNF-alpha and IL-6 (but not IL-1beta or IL-10) were higher in preeclamptic patients. We found significant correlation between plasma IL-6 and carbonyls, and these correlated to blood pressure.


CONCLUSIONS
We demonstrated that some oxidative and inflammatory mediators were altered in preeclampsia, and some correlated to blood pressure.
Bernardi
Fabiana
F
Experimental Physiopathology Laboratory, University of the Extreme South Catarinense, SC, Brazil.
Guolo
Francieli
F
Bortolin
Thaize
T
Petronilho
Fabricia
F
Dal-Pizzol
Felipe
F
D000328:Adult; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D018384:Oxidative Stress; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy / Q000097:blood*; D055815:Young Adult
D018836:Inflammation Mediators