title: Effects of yogurt supplemented with fish oil on plasma lipid and glucose concentrations, and liver lipid contents in mice.
abstract: The aim of this study is to clarify the effects of yogurt supplemented with fish oil on plasma lipid and glucose concentrations, and hepatic lipid contents in mice. Male Crlj:CD-1 (ICR) mice were fed five experimental diets for 12 weeks. The experimental diets were as follows: without yogurt and fish oil (control diet); 10% (w/w) yogurt without fish oil [10% FO(-)]; 10% yogurt with fish oil [10% FO(+)]; 30% yogurt without fish oil [30% FO(-)]; 30% yogurt with fish oil [30% FO(+)]. Plasma triacylglycerol concentrations in the 10% FO(+) and 30% FO(-) groups were significantly lower than that in the control diet group (p < 0.05 and p < 0.05, respectively). Plasma total cholesterol and phospholipid concentrations were significantly lower in the 30% FO(+) group than in the control diet group (p < 0.005). Concentrations tended to be lower with supplementation with fish oil. Plasma glucose concentrations in the 10% FO(+) and 30% FO(+) groups were significantly lower than those in the control diet group (p < 0.005 and p < 0.01, respectively). Hepatic triacylglycerol and total cholesterol contents in the 30% FO(+) group were significantly lower than those in the control diet group (p < 0.05 and p < 0.005, respectively). These results suggest that plasma triacylglycerol and glucose concentrations are effectively decreased by supplementation of yogurt with fish oil.
authors.affiliation: High Technology Research Center, Kagawa Nutrition University, 3-9-21, Chiyoda, Sakado, Saitama 350-0288, Japan. higuchi@eiyo.ac.jp
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Higuchi
authors.forename: Nobuya
authors.initials: N
authors.lastname: Shirai
authors.forename: Hiramitsu
authors.initials: H
authors.lastname: Suzuki
authors.forename: Masaru
authors.initials: M
authors.lastname: Kawashima
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Tamura
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D002784:Cholesterol / Q000097:blood; D004032:Diet / Q000379:methods; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D005395:Fish Oils / Q000008:administration & dosage*; D050356:Lipid Metabolism / Q000187:drug effects; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010743:Phospholipids / Q000097:blood; D014280:Triglycerides / Q000097:blood; D015014:Yogurt
chemical_list: D001786:Blood Glucose; D005395:Fish Oils; D008055:Lipids; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol