Condensed 1,4-dihydropyridines with various esters and their calcium channel antagonist activities.
New alkyl 2,6,6-(2,7,7)-trimethyl-4-(2-fluoro-3-chloro-5-trifluoromethylphenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylates and 9-(3-chloro-2-fluoro-5-trifluoromethylphenyl)-6,6(7,7)-dimethyl-6,7-dihydrofuro[3,4-b]quinoline-1,8-diones have been synthesised and their calcium antagonistic activities on isolated rabbit sigmoid colon have been investigated and compared with Nifedipine. The investigation examined the influence of ester groups in the 3-position of the HHQ ring and the 2-methoxyethyl analogs were found to be the most active derivatives.
Bülbül
Bahadir
B
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Turkey.
Oztürk
Gökçe Sevim
GS
Vural
Mert
M
Simşek
Rahime
R
Sarioğlu
Yusuf
Y
Linden
Anthony
A
Ulgen
Mert
M
Safak
Cihat
C
D000818:Animals; D002121:Calcium Channel Blockers / Q000737:chemistry*; D003106:Colon / Q000187:drug effects; D004095:Dihydropyridines / Q000737:chemistry* / Q000494:pharmacology; D004952:Esters; D066298:In Vitro Techniques; D011817:Rabbits; D013329:Structure-Activity Relationship
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D004952:Esters