Glycosylated hemoglobin and risk of colorectal cancer in men and women, the European prospective investigation into cancer and nutrition.
Although large-scale prospective cohort studies have related hyperglycemia to increased risk of cancer overall, studies specifically on colorectal cancer have been generally small. We investigated the association between prediagnostic levels of glycosylated hemoglobin (HbA1c), a marker for average glucose level in blood, and colorectal cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort. One thousand and twenty-six incident colorectal cancer cases (561 men and 465 women) and 1,026 matched controls were eligible for the study. Multivariate conditional logistic regression was used to estimate odds ratios (ORS) adjusted for possible confounders. Increasing HbA1c percentages were statistically significantly associated with a mild increase in colorectal cancer risk in the whole population [OR, 1.10; 95% confidence interval (CI), 1.01,1.19 for a 10% increase in HbA1c]. In women, increasing HbA1c percentages were associated with a statistically significant increase in colorectal cancer risk (OR, 1.16; 95% CI, 1.01, 1.32 for a 10% increase in HbA1c) and with a borderline statistically significant increase in rectum cancer (OR, 1.22; 95% CI, 0.99,1.50 for a 10% increase in HbA1c). No significant association with cancer risk was observed in men. The results of the current study suggest a mild implication of hyperglycemia in colorectal cancer, which seems more important in women than in men, and more for cancer of the rectum than of the colon.
Rinaldi
Sabina
S
IARC, 150, cours Albert Thomas, Lyon, 69372 Lyon Cedex 08, France. Rinaldi@iarc.fr
Rohrmann
Sabine
S
Jenab
Mazda
M
Biessy
Carine
C
Sieri
Sabina
S
Palli
Domenico
D
Tumino
Rosario
R
Mattiello
Amalla
A
Vineis
Paolo
P
Nieters
Alexandra
A
Linseisen
Jakob
J
Pischon
Tobias
T
Boeing
Heiner
H
Hallmans
Göran
G
Palmqvist
Richard
R
Manjer
Jonas
J
Wirfält
Elisabet
E
Crowe
Francesca L
FL
Khaw
Kay-Tee T
KT
Bingham
Sheila
S
Tjønneland
Anne
A
Olsen
Anja
A
Overvad
Kim
K
Lund
Eiliv
E
Skeie
Guri
G
Clavel-Chapelon
Francoise
F
Boutron-Ruault
Marie-Christine
MC
de Lauzon-Guillain
Blandine
B
Ardanaz
Eva
E
Jakszyn
Paula
P
Ramon Quiros
Jose
J
Chirlaque
Maria-Dolores
MD
Sanchez
Maria-Jose
MJ
Dorronsoro
Miren
M
Trichopoulou
Antonia
A
Lagiou
Pagona
P
Trichopoulos
Dimitrious
D
Bueno-de-Mesquita
H Bas
HB
van Duijnhoven
Fränzel J B
FJ
Peeters
Petra H M
PH
Slimani
Nadia
N
Ferrari
Pietro
P
Byrnes
Graham B
GB
Riboli
Elio
E
Kaaks
Rudolf
R
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D001786:Blood Glucose / Q000032:analysis; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002851:Chromatography, High Pressure Liquid; D015179:Colorectal Neoplasms / Q000097:blood* / Q000453:epidemiology*; D005060:Europe / Q000453:epidemiology; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D006943:Hyperglycemia / Q000097:blood* / Q000453:epidemiology*; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018570:Risk Assessment; D012737:Sex Factors; D011795:Surveys and Questionnaires
D014408:Biomarkers, Tumor; D001786:Blood Glucose; D006442:Glycated Hemoglobin