title: Correlation between cognitive deficits and glucose hypometabolism in mild cognitive impairment.
abstract: BACKGROUND
  In patients with mild cognitive impairment (MCI), poor performances on delayed recall and executive function are risk factors of progression to dementia. The aim of the present study was to clarify neural correlates of these neuropsychological deficits.
  
  
  METHODS
  Thirty patients with amnestic MCI and 15 control subjects underwent neuropsychological tests including three-word delayed recall, visual delayed recall of Rey complex figure (RCF), and two-relational reasoning of Raven's colored progressive matrices (RCPM) with a (18)F-fluorodeoxyglucose (FDG)-position emission tomography (PET) measurement of resting state. We evaluated a relationship between performance of neuropsychological tests and regional cerebral glucose metabolism using voxel-based analysis.
  
  
  RESULTS
  Poor performance in three-word delayed recall was related to glucose hypometabolism in the right medial temporal, right prefrontal, and left superior parietal cortices. The deficit in visual delayed recall of RCF correlated positively with hypometabolism in the bilateral posterior cingulate. The impairment in two-relational reasoning was associated with hypometabolism in the right prefrontal cortex.
  
  
  CONCLUSIONS
  The present findings suggest that hypometabolism in the right medial temporal cortex, right prefrontal cortex, left superior parietal cortex, and bilateral posterior cingulate reflects impairments in delayed recall while hypometabolism in the right prefrontal cortex mirrors deficits in executive function in MCI.
authors.affiliation: Human Brain Research Center, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-Ku, Kyoto, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Nishi
authors.forename: Nobukatsu
authors.initials: N
authors.lastname: Sawamoto
authors.forename: Chihiro
authors.initials: C
authors.lastname: Namiki
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Yoshida
authors.forename: Ha Duy Thuy
authors.initials: HD
authors.lastname: Dinh
authors.forename: Koichi
authors.initials: K
authors.lastname: Ishizu
authors.forename: Kazuo
authors.initials: K
authors.lastname: Hashikawa
authors.forename: Hidenao
authors.initials: H
authors.lastname: Fukuyama
mesh_terms: D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D001931:Brain Mapping; D003072:Cognition Disorders / Q000000981:diagnostic imaging / Q000378:metabolism*; D056344:Executive Function / Q000502:physiology*; D005260:Female; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D016014:Linear Models; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D011446:Prospective Studies; D014796:Visual Perception / Q000502:physiology
chemical_list: D019788:Fluorodeoxyglucose F18; D005947:Glucose