title: Significantly skewed memory CD8+ T cell subsets in HIV-1 infected infants during the first year of life.
abstract: HIV-1 infection causes a severe T cell compromise; however, little is known about changes in naive, memory, effector and senescent T cell subsets during the first year of life. T cell subsets were studied over the first year of life in blood from 3 infant cohorts: untreated HIV-infected, HIV-exposed but uninfected, and HIV-unexposed. In HIV-infected infants, the frequency of CCR7(+)CD45RA(+) naive CD8(+) T cells was significantly decreased, while the frequency of CCR7(-)CD45RA(-) effector memory CD8(+) T cells was increased, compared with the control cohorts. A larger population of CD8(+) T cells in HIV-infected infants displayed a phenotype consistent with senescence. Differences in CD4(+) T cell subset frequencies were less pronounced, and no significant differences were observed between exposed and unexposed HIV-uninfected infants. We concluded that the proportion of naive, memory, effector and senescent CD8(+) T cells during the first year of life is significantly altered by HIV-1 infection.
authors.affiliation: South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine and School of Child and Adolescent Health, University of Cape Town, Anzio Road, Observatory, 7925, South Africa.
authors.forename: Nazma
authors.initials: N
authors.lastname: Mansoor
authors.forename: Brian
authors.initials: B
authors.lastname: Abel
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Scriba
authors.forename: Jane
authors.initials: J
authors.lastname: Hughes
authors.forename: Marwou
authors.initials: M
authors.lastname: de Kock
authors.forename: Michele
authors.initials: M
authors.lastname: Tameris
authors.forename: Sylvia
authors.initials: S
authors.lastname: Mlenjeni
authors.forename: Lea
authors.initials: L
authors.lastname: Denation
authors.forename: Francesca
authors.initials: F
authors.lastname: Little
authors.forename: Sebastian
authors.initials: S
authors.lastname: Gelderbloem
authors.forename: Anthony
authors.initials: A
authors.lastname: Hawkridge
authors.forename: W Henry
authors.initials: WH
authors.lastname: Boom
authors.forename: Gilla
authors.initials: G
authors.lastname: Kaplan
authors.forename: Gregory D
authors.initials: GD
authors.lastname: Hussey
authors.forename: Willem A
authors.initials: WA
authors.lastname: Hanekom
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000821:virology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology; D002452:Cell Count; D002454:Cell Differentiation; D005260:Female; D005434:Flow Cytometry; D015658:HIV Infections / Q000276:immunology* / Q000635:transmission; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D010641:Phenotype; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology*