title: Switching from calcium carbonate to sevelamer hydrochloride has suppressive effects on the progression of aortic calcification in hemodialysis patients: assessment using plain chest X-ray films.
abstract: Sevelamer hydrochloride, a non-aluminum- and non-calcium-containing hydrogel, is an effective phosphate binder in dialysis patients. The suppressive effect of the switching from calcium carbonate to sevelamer hydrochloride on the progression of vascular calcification was examined by measuring areas of calcification on routine chest X-rays using image-analyzing software. The data of 69 maintenance hemodialysis patients were analyzed retrospectively. Over a period of 18 months, 19 patients took only sevelamer hydrochloride as a phosphate binder, while the other 50 patients took only calcium carbonate. The area of calcification increased in the calcium carbonate group, but did not change significantly in the sevelamer group. While the usefulness of computed tomography in detecting vascular calcification in hemodialysis patients has been reported previously, the suppressive effects of switching from calcium carbonate to sevelamer hydrochloride on the progression of aortic calcification can be observed without computed tomography by using the plain chest X-ray films that are routinely performed in hemodialysis clinics.
authors.affiliation: Division of Kidney and Dialysis, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan. izumi@kanrou.net
authors.forename: Masaaki
authors.initials: M
authors.lastname: Izumi
authors.forename: Syunpei
authors.initials: S
authors.lastname: Morita
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Nishian
authors.forename: Takashi
authors.initials: T
authors.lastname: Miyamoto
authors.forename: Hiroomi
authors.initials: H
authors.lastname: Kasumoto
authors.forename: Mai
authors.initials: M
authors.lastname: Oue
authors.forename: Kahori
authors.initials: K
authors.lastname: Hori
authors.forename: Rie
authors.initials: R
authors.lastname: Kitamura
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nakanishi
mesh_terms: D000368:Aged; D000863:Antacids / Q000627:therapeutic use; D001018:Aortic Diseases / Q000000981:diagnostic imaging / Q000209:etiology / Q000517:prevention & control*; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000517:prevention & control*; D002119:Calcium Carbonate / Q000627:therapeutic use*; D002614:Chelating Agents / Q000627:therapeutic use*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011073:Polyamines / Q000627:therapeutic use*; D013902:Radiography, Thoracic; D006435:Renal Dialysis; D012189:Retrospective Studies; D000069603:Sevelamer
chemical_list: D000863:Antacids; D002614:Chelating Agents; D011073:Polyamines; D000069603:Sevelamer; D002119:Calcium Carbonate