Romanian anti-TB drugs resistance surveillance 2003-2004.
Romania decided and initiated a DRS for anti-TB drugs at national level using the standardized methodology proposed by WHO and IUATLD. The DRS protocol was designed with technical assistance from WHO; the surveillance started in June 2003 and ended in June 2004. It was tested the susceptibility to the 4 first line anti-TB drugs: Isoniazide (H), Rifampicin (R), Streptomycin (S), Ethambutol (E). Drug susceptibility testing used: indirect absolute concentration method. There were included in the survey 1251 TB patients from the 60 clusters: 869 new cases and 382 previously treated. From the penitentiary system were included 85 TB patients, 47 new cases and 38 previously treated.


RESULTS
[table: see text]. Estimations of the trend of anti-TB drug resistance in Romania for the next period was proposed.
Stoicescu
Ioan Paul
IP
Marius Nasta Institute of Pneumology, Bucharest, Romania. stoicescup@yahoo.com
Homorodean
Daniela
D
Chiotan
Domnica
D
Moldovan
Olga
O
Diculencu
Daniela
D
Popa
Cristian
C
Macri
Anca
A
Husar
Iuliana
I
Diţiu
Lucica
L
Aziz
Mohamed Abdel
MA
Hoffner
Sven
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000494:pharmacology*; D016000:Cluster Analysis; D024881:Drug Resistance, Bacterial; D004977:Ethambutol / Q000494:pharmacology; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000494:pharmacology; D008297:Male; D008826:Microbial Sensitivity Tests / Q000379:methods; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D011159:Population Surveillance; D011329:Prisoners; D012293:Rifampin / Q000494:pharmacology; D012383:Romania / Q000453:epidemiology; D013307:Streptomycin / Q000494:pharmacology; D018088:Tuberculosis, Multidrug-Resistant / Q000453:epidemiology*; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology*; D014944:World Health Organization; D055815:Young Adult
D000995:Antitubercular Agents; D004977:Ethambutol; D007538:Isoniazid; D012293:Rifampin; D013307:Streptomycin