Single-nucleotide polymorphisms in Rv2629 are specific for Mycobacterium tuberculosis genotypes Beijing and Ghana but not associated with rifampin resistance.
Sequence analysis of 58 multidrug-resistant Mycobacterium tuberculosis complex strains from Germany and 55 susceptible strains from a reference collection comprising major phylogenetic lineages confirmed that variations in Rv2629, 191A/C and 965C/T, are specific for genotypes Beijing and Ghana, respectively, but not involved in the development of rifampin (rifampicin) resistance.
Homolka
Susanne
S
Forschungszentrum Borstel, National Reference Center for Mycobacteria, Research Center Borstel, Parkallee 1, Borstel, Germany.
Köser
Claudio
C
Archer
John
J
Rüsch-Gerdes
Sabine
S
Niemann
Stefan
S
D000995:Antitubercular Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics*; D004269:DNA, Bacterial / Q000235:genetics*; D024881:Drug Resistance, Bacterial; D005838:Genotype; D005858:Germany; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000145:classification* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012293:Rifampin / Q000494:pharmacology*
D000995:Antitubercular Agents; D001426:Bacterial Proteins; D004269:DNA, Bacterial; C527629:Rv2629 protein, Mycobacterium; D012293:Rifampin