Regulation of stem cell differentiation by histone methyltransferases and demethylases.
The generation of different cell types from stem cells containing identical genetic information and their organization into tissues and organs during development is a highly complex process that requires defined transcriptional programs. Maintenance of such programs is epigenetically regulated and the factors involved in these processes are often essential for development. The activities required for cell-fate decisions are frequently deregulated in human tumors, and the elucidation of the molecular mechanisms that regulate these processes is therefore important for understanding both developmental processes and tumorigenesis.
Pasini
D
D
Biotech Research and Innovation Centre, University of Copenhagen, Ole Maaløes Vej 5, Copenhagen, Denmark.
Bracken
A P
AP
Agger
K
K
Christensen
J
J
Hansen
K
K
Cloos
P A C
PA
Helin
K
K
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics* / Q000502:physiology*; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D018507:Gene Expression Regulation, Developmental; D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase / Q000235:genetics / Q000378:metabolism*; D006657:Histones / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D010089:Oxidoreductases, N-Demethylating / Q000235:genetics / Q000378:metabolism*; D063146:Polycomb-Group Proteins; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology* / Q000201:enzymology*; D014158:Transcription, Genetic
D006657:Histones; D063146:Polycomb-Group Proteins; D012097:Repressor Proteins; D010089:Oxidoreductases, N-Demethylating; D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase