title: Effect of denervation and ischemia reperfusion injury on serum nitric oxide levels in rats.
abstract: OBJECTIVE
  To evaluate the effect of renal denervation and serum nitric oxide level with a different time course of renal ischemia-reperfusion injury.
  
  
  METHODS
  Thirty-six male Wistar rats were randomized into 6 groups. All rats underwent right nephrectomy to create a single kidney model. Renal denervated and innerved rats were subjected to renal clamping for 30-60 minutes. The study was performed in the Department of Anatomy, Akdeniz University, Antalya, Turkey, between June and November 2005.
  
  
  RESULTS
  Combined effect of denervation and ischemia may caused significant increase in serum nitric oxide levels and decrease in glomerular filtration rates.
  
  
  CONCLUSIONS
  Our results indicate that kidney denervation did not cause any changes in renal functions, but with ischemia it worsens the deleterious effect of ischemia-reperfusion injury, and causes a significant increase in serum nitric oxide levels.
authors.affiliation: Department of Anatomy, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
authors.forename: Umut
authors.initials: U
authors.lastname: Ozsoy
authors.forename: Ruya
authors.initials: R
authors.lastname: Mutluay
authors.forename: Nezih
authors.initials: N
authors.lastname: Oygur
authors.forename: Halide
authors.initials: H
authors.lastname: Akbas
authors.forename: Sukru
authors.initials: S
authors.lastname: Sindel
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Sindel
mesh_terms: D000818:Animals; D003714:Denervation; D008297:Male; D009569:Nitric Oxide / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury
chemical_list: D009569:Nitric Oxide