Demethoxycurcumin and its semisynthetic analogues as antitubercular agents.
Demethoxycurcumin, isolated from the rhizomes of Curcuma longa, was found to possess antitubercular activity against Mycobacterium tuberculosis H (37)Rv strain at 200 microg/mL. Derivatisation of this active principle yielded a potent agent 6, exhibiting considerable activity with a minimum inhibitory concentration (MIC) value of 7.8 microg/mL. H (37)Rv:Mycobacterium tuberculosis H (37)Rv strain MIC:minimum inhibitory concentration.
Agrawal
Dinesh Kumar
DK
Analytical Chemistry Division, Central Institute of Medicinal and Aromatic Plants (CIMAP-CSIR), Lucknow, India.
Saikia
Dharmendra
D
Tiwari
Richa
R
Ojha
Shweta
S
Shanker
Karuna
K
Kumar
Jonnala Kotesh
JK
Gupta
Anil Kumar
AK
Tandon
Sudeep
S
Negi
Arvind Singh
AS
Khanuja
Suman Preet
SP
D000995:Antitubercular Agents / Q000302:isolation & purification / Q000494:pharmacology*; D030024:Curcuma / Q000737:chemistry*; D003474:Curcumin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D036381:Diarylheptanoids; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D027343:Rhizome
D000995:Antitubercular Agents; D036381:Diarylheptanoids; D010936:Plant Extracts; D003474:Curcumin; C050229:demethoxycurcumin