title: Chiral gamma-aryl-1H-1,2,4-triazole derivatives as highly potential antifungal agents: Design, synthesis, structure, and in vitro fungicidal activities.
abstract: A novel series of chiral gamma-aryl-1H-1,2,4-triazole derivatives as highly potential antifungal agents have been designed and synthesized conveniently by using the chiral auxiliary as a controlling reagent. All of the compounds exhibit moderate to high ee values reaching up to 99%, and the preliminary bioassay results demonstrated that most of the target compounds take on a significantly wide spectrum activity against Fusarium oxysporium, Rhizoctonia solani, Botrytis cinereapers, Gibberella zeae, Dothiorella gregaria, and Colletotrichum gossypii species.
authors.affiliation: Central China Normal University, Wuhan, People's Republic of China.
authors.forename: Xiufang
authors.initials: X
authors.lastname: Cao
authors.forename: Fei
authors.initials: F
authors.lastname: Li
authors.forename: Ming
authors.initials: M
authors.lastname: Hu
authors.forename: Wenchang
authors.initials: W
authors.lastname: Lu
authors.forename: Guang-Ao
authors.initials: GA
authors.lastname: Yu
authors.forename: Sheng Hua
authors.initials: SH
authors.lastname: Liu
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D015195:Drug Design; D005658:Fungi / Q000187:drug effects*; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C045575:1,2,4-triazole