title: Expression of the follicular lymphoma variant translocation 1 gene in diffuse large B-cell lymphoma correlates with subtype and clinical outcome.
abstract: Sphingolipids serve an important role as effector molecules in signaling pathways bearing on apoptosis and cell survival. The balance between proapoptotic ceramide and prosurvival sphingosine-1-phosphate, sometimes termed the "sphingolipid rheostat," has received particular attention. Less well studied is the role of the follicular lymphoma variant translocation 1 (FVT1) gene, which was identified through its involvement in an atypical follicular lymphoma translocation and which encodes an enzyme in the synthetic pathway of ceramide. We investigated the expression of FVT1 in a variety of B-cell non-Hodgkin lymphomas and found that FVT1 is significantly underexpressed by germinal center-type diffuse large B-cell lymphoma (DLBCL) when compared with non-germinal center-type DLBCL, follicular lymphoma, and normal tonsil control samples. Increased expression of FVT1 correlated with decreased survival, suggesting that changes in the expression of FVT1 and in the concentrations of bioactive sphingolipids may be important in the pathogenesis and treatment of some types of DLBCL.
authors.affiliation: Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA.
authors.forename: David R
authors.initials: DR
authors.lastname: Czuchlewski
authors.forename: Balazs
authors.initials: B
authors.lastname: Csernus
authors.forename: Darya
authors.initials: D
authors.lastname: Bubman
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Hyjek
authors.forename: Peter
authors.initials: P
authors.lastname: Martin
authors.forename: Amy
authors.initials: A
authors.lastname: Chadburn
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Knowles
authors.forename: Ethel
authors.initials: E
authors.lastname: Cesarman
mesh_terms: D000429:Alcohol Oxidoreductases / Q000096:biosynthesis / Q000235:genetics*; D002518:Ceramides / Q000096:biosynthesis; D015972:Gene Expression Regulation, Neoplastic; D018858:Germinal Center / Q000201:enzymology; D006801:Humans; D053208:Kaplan-Meier Estimate; D008224:Lymphoma, Follicular / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D014066:Palatine Tonsil / Q000201:enzymology; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D002518:Ceramides; D000429:Alcohol Oxidoreductases; C023943:3-ketodihydrosphingosine reductase