title: Evaluation of required saline volume in dynamic contrast-enhanced computed tomography using saline flush technique.
abstract: The present study was performed to find the required volume of physiological saline for flushing that will allow the most efficient use of contrast medium during the early phase of dynamic CT. We calculated contrast medium aortic arrival time (AT), time to peak aortic enhancement (TPAE) and the elapsed time to TPAE from AT (rise time) from the TECs of pharmacokinetic analysis and clinical study. The rise time determined in the clinical study was 6.2s, which was shorter than that in the simulation study. In the present study, an appropriate volume for saline flush was estimated to be about 18 ml.
authors.affiliation: Radiological Center, University of Fukui Hospital, 23-3, Matsuokashimoaizuki, eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan. isaoyama@u-fukui.ac.jp
authors.forename: Isao
authors.initials: I
authors.lastname: Yamaguchi
authors.forename: Eiji
authors.initials: E
authors.lastname: Kidoya
authors.forename: Masayuki
authors.initials: M
authors.lastname: Suzuki
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Kimura
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging; D003287:Contrast Media / Q000737:chemistry / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007201:Indicator Dilution Techniques / Q000592:standards; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D019999:Pharmaceutical Solutions / Q000737:chemistry / Q000493:pharmacokinetics; D012965:Sodium Chloride / Q000737:chemistry / Q000493:pharmacokinetics*; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; D019999:Pharmaceutical Solutions; D012965:Sodium Chloride