title: Sulfonamido-aryl ethers as bradykinin B1 receptor antagonists.
abstract: The synthesis and identification of sulfonamido-aryl ethers as potent bradykinin B1 receptor antagonists from a approximately 60,000 member encoded combinatorial library are reported. Two distinct series of compounds exhibiting different structure-activity relationships were identified in a bradykinin B1 whole-cell receptor-binding assay. Specific examples exhibit K(i) values of approximately 10nM.
authors.affiliation: Pharmacopeia Inc, Princeton, NJ 08543, USA. acole@pcop.com
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Cole
authors.forename: Axel
authors.initials: A
authors.lastname: Metzger
authors.forename: Marc-Raleigh
authors.initials: MR
authors.lastname: Brescia
authors.forename: Lan-Ying
authors.initials: LY
authors.lastname: Qin
authors.forename: Kenneth C
authors.initials: KC
authors.lastname: Appell
authors.forename: Christopher T
authors.initials: CT
authors.lastname: Brain
authors.forename: Allan
authors.initials: A
authors.lastname: Hallett
authors.forename: Pam
authors.initials: P
authors.lastname: Ganju
authors.forename: Alastair A
authors.initials: AA
authors.lastname: Denholm
authors.forename: James R
authors.initials: JR
authors.lastname: Wareing
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Ritchie
authors.forename: Gillian M
authors.initials: GM
authors.lastname: Drake
authors.forename: Stuart J
authors.initials: SJ
authors.lastname: Bevan
authors.forename: Aisling
authors.initials: A
authors.lastname: MacGloinn
authors.forename: Andrew
authors.initials: A
authors.lastname: McBryde
authors.forename: Viral
authors.initials: V
authors.lastname: Patel
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Oakley
authors.forename: Ximena
authors.initials: X
authors.lastname: Nunez
authors.forename: Hubert
authors.initials: H
authors.lastname: Gstach
authors.forename: Peter
authors.initials: P
authors.lastname: Schneider
authors.forename: John J
authors.initials: JJ
authors.lastname: Baldwin
authors.forename: Roland E
authors.initials: RE
authors.lastname: Dolle
authors.forename: Edward
authors.initials: E
authors.lastname: McDonald
authors.forename: Ian
authors.initials: I
authors.lastname: Henderson
mesh_terms: D000818:Animals; D065169:Bradykinin B1 Receptor Antagonists; D002460:Cell Line; D020650:Combinatorial Chemistry Techniques; D004987:Ethers / Q000138:chemical synthesis*; D006801:Humans; D054852:Small Molecule Libraries; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D065169:Bradykinin B1 Receptor Antagonists; D004987:Ethers; D054852:Small Molecule Libraries; D013449:Sulfonamides