Cord blood stem cell therapy for acquired immune deficiency syndrome.
Cord blood stem cell transplantation is routinely used to treat hematopoietic diseases. Individuals who are homozygous for the 32 polymorphism of the CCR5 locus, encoding a co-receptor for HIV-1, are normal and are resistant to HIV infection. Here we suggest that public cord blood repositories are likely to contain CCR5 homozygous units that could be used as a therapy for HIV-infected individuals.
Gonzalez
Gabriel
G
Department of Genetics, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.
Shpall
Elizabeth J
EJ
Gathe
Joseph C
JC
Behringer
Richard R
RR
D000163:Acquired Immunodeficiency Syndrome / Q000601:surgery*; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D036101:Cord Blood Stem Cell Transplantation; D005312:Fetal Blood / Q000166:cytology*; D015497:HIV-1 / Q000378:metabolism; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000502:physiology*; D006801:Humans; D011110:Polymorphism, Genetic; D019713:Receptors, CCR5 / Q000235:genetics
D019713:Receptors, CCR5