title: Activity of levofloxacin alone and in combination with a DnaK inhibitor against gram-negative rods, including levofloxacin-resistant strains.
abstract: Synergy time-kill testing of levofloxacin alone and in combination with CHP-105, a representative DnaK inhibitor, against 50 gram-negative rods demonstrated that 34 of the 50 strains tested showed significant synergy between levofloxacin and CHP-105 after 12 h and 24 h. Fourteen of these 34 organisms were quinolone resistant (levofloxacin MICs of > or =4 microg/ml).
authors.affiliation: Department of Pathology, Hershey Medical Center, PA 17033, USA.
authors.forename: Kim
authors.initials: K
authors.lastname: Credito
authors.forename: Gengrong
authors.initials: G
authors.lastname: Lin
authors.forename: Laura
authors.initials: L
authors.lastname: Koeth
authors.forename: Michael A
authors.initials: MA
authors.lastname: Sturgess
authors.forename: Peter C
authors.initials: PC
authors.lastname: Appelbaum
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000494:pharmacology; D015169:Colony Count, Microbial; D004338:Drug Combinations; D024881:Drug Resistance, Bacterial; D029968:Escherichia coli Proteins / Q000037:antagonists & inhibitors*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D018840:HSP70 Heat-Shock Proteins / Q000037:antagonists & inhibitors*; D019476:Insect Proteins / Q000494:pharmacology; D064704:Levofloxacin; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D004338:Drug Combinations; D029968:Escherichia coli Proteins; D018840:HSP70 Heat-Shock Proteins; D019476:Insect Proteins; C087710:pyrrhocoricin protein, Pyrrhocoris apterus; D064704:Levofloxacin; D015242:Ofloxacin; C063842:dnaK protein, E coli