Imaging virus-associated cancer.
Cancer remains an important and growing health problem. Researchers have made great progress in defining genetic and molecular alterations that contribute to cancer formation and progression. Molecular imaging can identify appropriate patients for targeted cancer therapy and may detect early biochemical changes in tumors during therapy, some of which may have important prognostic implications. Progress in this field continues largely due to a union between molecular genetics and advanced imaging technology. This review details uses of molecular-genetic imaging in the context of tumor-associated viruses. Under certain conditions, and particularly during pharmacologic stimulation, gammaherpesviruses will express genes that enable imaging and therapy in vivo. The techniques discussed are readily translatable to the clinic.
Fu
De-Xue
DX
Sidney Kimmel Cancer Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.
Foss
Catherine A
CA
Nimmagadda
Sridhar
S
Ambinder
Richard F
RF
Pomper
Martin G
MG
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D016503:Drug Delivery Systems; D018142:Gammaherpesvirinae / Q000235:genetics / Q000378:metabolism; D005814:Genes, Viral; D006566:Herpesviridae Infections / Q000000981:diagnostic imaging / Q000235:genetics; D006801:Humans; D008967:Molecular Biology / Q000379:methods*; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics / Q000821:virology; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D014412:Tumor Virus Infections / Q000000981:diagnostic imaging* / Q000235:genetics
D000970:Antineoplastic Agents; D019275:Radiopharmaceuticals