title: Use of ribozymes and antisense oligodeoxynucleotides to investigate mechanisms of drug resistance.
abstract: Chemotherapy can cure a number of human cancers but resistance (either intrinsic or acquired) remains a significant problem in many patients and in many types of solid tumour. Combination chemotherapy (using drugs with different cellular targets/mechanisms) was introduced in order to kill cells which had developed resistance to a specific drug, and to allow delivery of a greater total dose of anti-cancer chemicals by combining drugs with different side-effects (Pratt et al., 1994). Nearly all anti-cancer drugs kill tumour cells by activating an endogenous bio-chemical pathway for cell suicide, known as programmed cell death or apoptosis.
authors.affiliation: National Cell and Tissue Culture Centre, Dublin City University, Glasnevin, Dublin 9, Ireland.
authors.forename: D
authors.initials: D
authors.lastname: Byrne
authors.forename: C
authors.initials: C
authors.lastname: Daly
authors.forename: R
authors.initials: R
authors.lastname: Nicamhlaoibh
authors.forename: A
authors.initials: A
authors.lastname: Howlett
authors.forename: K
authors.initials: K
authors.lastname: Scanlon
authors.forename: M
authors.initials: M
authors.lastname: Clynes