Hypothyroidism and dyshormonogenesis induced by D-penicillamine in children with Wilson's disease and healthy infants born to a mother with Wilson's disease.
Two siblings born to a mother with Wilson's disease, who was taking D-penicillamine, developed transient goitrous hypothyroidism. A prospective evaluation of 5 patients with Wilson's disease taking and not taking D-penicillamine for as long as 9.5 years showed subclinical hypothyroidism. D-penicillamine probably inhibited thyroperoxidase activity in utero in healthy infants and during childhood in patients with Wilson's disease.
Hanukoglu
Aaron
A
Division of Pediatric Endocrinology, E. Wolfson Medical Center, Holon, Israel; Tel-Aviv University, Sackler School of Medicine, Israel.
Curiel
Batya
B
Berkowitz
Drora
D
Levine
Arieh
A
Sack
Joseph
J
Lorberboym
Mordehai
M
D000293:Adolescent; D002614:Chelating Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D002648:Child; D005260:Female; D006042:Goiter / Q000139:chemically induced* / Q000188:drug therapy; D006527:Hepatolenticular Degeneration / Q000188:drug therapy*; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced* / Q000188:drug therapy; D007231:Infant, Newborn; D008297:Male; D008431:Maternal-Fetal Exchange; D010396:Penicillamine / Q000009:adverse effects* / Q000627:therapeutic use*; D011247:Pregnancy; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000627:therapeutic use
D002614:Chelating Agents; D013972:Thyrotropin; D010396:Penicillamine; D013974:Thyroxine