title: Antimicrobial susceptibility testing of Bordetella pertussis in Taiwan prompted by a case of pertussis in a paediatric patient.
abstract: In Taiwan, pertussis is a notifiable disease with a low incidence in recent years, and antimicrobial susceptibility testing for the causative agent, Bordetella pertussis, has not been reported to date. In May 2007, the Centers for Disease Control, Taiwan, was informed of a 1-month-old pertussis patient who did not respond to erythromycin treatment. In this study, we report the result of antimicrobial susceptibility testing performed for the suspected erythromycin-resistant isolate, as well as for an additional 27 B. pertussis clinical isolates that represented almost all epidemiologically unrelated isolates obtained throughout Taiwan between 2003 and 2007. All isolates were fully susceptible to azithromycin, erythromycin, clarithromycin and trimethoprim/sulfamethoxazole (MIC < or =0.047 mug ml(-1)). This result demonstrates the general susceptibility of B. pertussis to antimicrobial agents in vitro in Taiwan.
authors.affiliation: Research and Diagnostic Center, Centers for Disease Control, Taipei, Taiwan, ROC.
authors.forename: Shu-Man
authors.initials: SM
authors.lastname: Yao
authors.affiliation: Department of Life Sciences and Program in Genome Sciences, National Yang-Ming University, Taipei, Taiwan, ROC.
authors.forename: Gwo-Jen
authors.initials: GJ
authors.lastname: Liaw
authors.affiliation: Research and Diagnostic Center, Centers for Disease Control, Taipei, Taiwan, ROC.
authors.forename: Ying-Yan
authors.initials: YY
authors.lastname: Chen
authors.affiliation: Departments of Pediatrics, Chang Gung Children's Hospital, Chang Gung Memorial Hospital and Chang Gung University School of Medicine, Taoyuan, Taiwan, ROC.
authors.forename: Meng-Hsiu
authors.initials: MH
authors.lastname: Yen
authors.affiliation: Research and Diagnostic Center, Centers for Disease Control, Taipei, Taiwan, ROC.
authors.forename: Ya-Hui
authors.initials: YH
authors.lastname: Chen
authors.affiliation: Research and Diagnostic Center, Centers for Disease Control, Taipei, Taiwan, ROC.
authors.forename: Jung-Jung
authors.initials: JJ
authors.lastname: Mu
authors.affiliation: Center of General Education, National Taipei College of Nursing, Taipei, Taiwan, ROC.|Research and Diagnostic Center, Centers for Disease Control, Taipei, Taiwan, ROC.
authors.forename: Chuen-Sheue
authors.initials: CS
authors.lastname: Chiang
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001886:Bordetella pertussis / Q000187:drug effects* / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D004917:Erythromycin / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007223:Infant; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D008297:Male; D008826:Microbial Sensitivity Tests; D013624:Taiwan; D014917:Whooping Cough / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D004917:Erythromycin