title: Outcome of severely anaemic fetuses treated by intrauterine transfusions.
abstract: BACKGROUND
  Fetal anaemia is a well-known complication of pregnancy, which might have an ominous effect on the course of pregnancy, labour and the child's development.
  
  
  OBJECTIVE
  To assess the effect of the severity of fetal anaemia on the child's outcome.
  
  
  METHODS
  A retrospective cohort study. Pregnancies treated by intrauterine transfusions for fetal anaemia at Sheba Medical Center (1996-2004) were divided into two groups: mild to moderate anaemia (fetal haematocrit >0.50 multiples of the median (MoM)) and severe anaemia (hydrops fetalis or fetal haematocrit < or =0.50 MoM). Data were retrieved from relevant obstetric and fetal medicine files.
  
  
  RESULTS
  During the study period, 54 fetuses were treated by 154 (median 3; range 1-7) intrauterine transfusions for red cell alloimmunisation. The sensitising antigen was D in 70% of cases; 18/54 patients were sensitised to more than one antigen. Thirty-three of the 54 fetuses (61%) were in the severely anaemic category (haematocrit range 3-20%); six were hydropic. Twenty-one of the 54 fetuses (39%) were in the mild-moderate anaemic category (haematocrit range 20-37%). On prenatal evaluation, there were no sonographic markers of central nervous system abnormalities or intraventricular haemorrhage. There were no differences in the neonatal outcome between the two groups. Developmental outcome was available in 14/18 (78%) mild-moderate cases and 26/29 (89%) severe cases. There were no significant differences in motor development score, percentage of abnormal cognitive development, and percentage of children needing supportive therapy between the mild-moderate and severe cases.
  
  
  CONCLUSIONS
  Neonatal and developmental outcome of fetuses treated for severe anaemia is comparable to cases of mild anaemia.
authors.affiliation: Department of Obstetrics and Gynecology, The Chaim Sheba Medical Center, Tel Hashomer 52621, Israel. boazmd@zahav.net.il
authors.forename: B
authors.initials: B
authors.lastname: Weisz
authors.forename: O
authors.initials: O
authors.lastname: Rosenbaum
authors.forename: B
authors.initials: B
authors.lastname: Chayen
authors.forename: R
authors.initials: R
authors.lastname: Peltz
authors.forename: B
authors.initials: B
authors.lastname: Feldman
authors.forename: S
authors.initials: S
authors.lastname: Lipitz
mesh_terms: D000740:Anemia / Q000453:epidemiology* / Q000628:therapy; D001805:Blood Transfusion, Intrauterine; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D003072:Cognition Disorders / Q000453:epidemiology*; D015331:Cohort Studies; D005260:Female; D005315:Fetal Diseases / Q000453:epidemiology* / Q000628:therapy; D006801:Humans; D007223:Infant; D007557:Israel / Q000453:epidemiology; D019957:Motor Skills Disorders / Q000453:epidemiology*; D011247:Pregnancy; D012189:Retrospective Studies; D016896:Treatment Outcome