title: Polymorphism in CC-chemokine ligand 2 associated with tuberculosis in Zambia.
abstract: Polymorphism in various genes that may influence susceptibility to tuberculosis (TB) was examined in 46 TB patients and 119 healthy tuberculin-positive controls in Zambia. The odds of having TB was 2.8-fold higher in carriers of the -2518 AG single-nucleotide polymorphism in the promoter region of the CC-chemokine ligand 2 than in those carrying the homozygous genotype AA (95%CI 1.3-5.5).
authors.affiliation: Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Centre, University Medical Centre Rotterdam, Rotterdam, The Netherlands. P.Buijtels@umcutrecht.nl
authors.forename: P C A M
authors.initials: PC
authors.lastname: Buijtels
authors.forename: W W J
authors.initials: WW
authors.lastname: van de Sande
authors.forename: S
authors.initials: S
authors.lastname: Parkinson
authors.forename: P L C
authors.initials: PL
authors.lastname: Petit
authors.forename: M A B
authors.initials: MA
authors.lastname: van der Sande
authors.forename: D
authors.initials: D
authors.lastname: van Soolingen
authors.forename: H A
authors.initials: HA
authors.lastname: Verbrugh
authors.forename: A
authors.initials: A
authors.lastname: van Belkum
mesh_terms: D000328:Adult; D018932:Chemokine CCL2 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D014376:Tuberculosis / Q000235:genetics*; D015024:Zambia
chemical_list: D018932:Chemokine CCL2