Chinese cabbage (Brassica campestris L.) does not improve glucose tolerance, serum insulin, or blood lipid profiles in a rat model of type-2 diabetes.
The present study was conducted to investigate the effects of a low (0.5%) and a high (2.0%) dietary dose of freeze-dried Chinese cabbage (CC) (Brassica campestris L.) powder in a type-2 diabetes (T2D) model of rats. Five-week-old male Sprague-Dawley rats were fed a high fat (HF)-containing diet for 2 wk then randomly divided into 4 groups of 8 animals, namely: normal control (NC), diabetic control (DBC), Chinese cabbage low (CCL, 0.5%), and Chinese cabbage high (CCH, 2.0%) groups. Diabetes was induced by an intraperitoneal injection of streptozotocin (STZ; 40 mg/kg body weight) in all groups except the NC group. After 4 wk feeding of experimental diets, although food intake was not different among the DBC, CCL, and CCH groups, body weight gain was significantly (P < 0.05) higher in the CCH group compared to the DBC group. Relatively higher serum insulin concentrations and better glucose tolerance were observed in the CC-fed groups compared to the DBC group; however, the results were not significantly different. Fasting blood glucose, blood glycated hemoglobin (HbA1c), liver weight, and liver glycogen levels were not influenced by the CC-containing diets. Additionally, hypertriglyceridemic tendencies were observed in the CC-fed groups compared to the NC and DBC groups, while difference observed for total-, HDL-, and LDL-cholesterols between the groups were negligible. Results of this study suggest that up to 2% dietary dose of freeze-dried CC is not significantly effective to reduce diabetes-related symptoms in an HF diet-fed STZ-induced T2D model of rats.
Islam
M S
MS
Department of Food and Nutrition, Seoul National University, Seoul 151-742, South Korea. sislam1974@yahoo.com
Choi
H
H
D000821:Animal Feed; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology; D001937:Brassica; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000178:diet therapy; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000178:diet therapy; D002149:Energy Intake; D005612:Freeze Drying; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000378:metabolism; D007328:Insulin / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000033:anatomy & histology; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D009929:Organ Size; D051381:Rats; D017207:Rats, Sprague-Dawley; D015430:Weight Gain
D000975:Antioxidants; D006442:Glycated Hemoglobin; D007328:Insulin; D008055:Lipids; D008112:Liver Glycogen