Acute respiratory failure involving an R variant of Mycobacterium abscessus.
We report the case of a cystic fibrosis patient colonized with a smooth-morphotype form of Mycobacterium abscessus who developed acute respiratory failure with the emergence of an isogenic rough (R) variant while he was recovering from peritonitis-induced shock. This report emphasizes the role of R forms in severe M. abscessus infections.
Catherinot
Emilie
E
Laboratoire de Microbiologie, AP-HP, Hôpital Raymond Poincaré et Hôpital Ambroise Paré, and Université de Versailles-Saint-Quentin-en-Yvelines, EA3647, Garches, France.
Roux
Anne-Laure
AL
Macheras
Edouard
E
Hubert
Dominique
D
Matmar
Moussa
M
Dannhoffer
Luc
L
Chinet
Thierry
T
Morand
Philippe
P
Poyart
Claire
C
Heym
Beate
B
Rottman
Martin
M
Gaillard
Jean-Louis
JL
Herrmann
Jean-Louis
JL
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003550:Cystic Fibrosis / Q000150:complications*; D016172:DNA Fingerprinting; D004269:DNA, Bacterial / Q000235:genetics; D006801:Humans; D008297:Male; D009161:Mycobacterium / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D009164:Mycobacterium Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D010538:Peritonitis / Q000150:complications*; D013902:Radiography, Thoracic; D019105:Random Amplified Polymorphic DNA Technique; D012131:Respiratory Insufficiency / Q000209:etiology* / Q000628:therapy
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial