Novel mouse models for understanding HIV-1 pathogenesis.
Small animal models in which in vivo HIV-1 infection, pathogenesis, and immune responses can be studied would permit both basic research on the biology of the disease, as well as a system to rapidly screen developmental therapeutics and/or vaccines. To date, the most widely-used models have been the severe combined immunodeficient (SCID)-hu (also known as the thy/liv SCID-hu) and the huPBL-SCID mouse models. Recently three new models have emerged, i.e., the intrasplenic huPBL/SPL-SCID model, the NOD/SCID/IL2Rgamma(null) mouse model, and the Rag2(-/-)gamma(c) (-/-) mouse model. Details on the construction, maintenance and HIV-1 infection of these models are discussed.
Joseph
Aviva
A
Department of Microbiology, Albert Einstein College of Medicine, Bronx, NY, USA.
Sango
Kaori
K
Goldstein
Harris
H
D000818:Animals; D004268:DNA-Binding Proteins / Q000172:deficiency; D004195:Disease Models, Animal; D005260:Female; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000502:physiology*; D053631:Interleukin Receptor Common gamma Subunit / Q000172:deficiency; D008297:Male; D051379:Mice; D016513:Mice, SCID
D004268:DNA-Binding Proteins; C507942:Il2rg protein, mouse; D053631:Interleukin Receptor Common gamma Subunit; C499308:Rag2 protein, mouse