Trypanosome RNA polymerases and transcription factors: sensible trypanocidal drug targets?
Trypanosomes and Leishmaniae are the agents of several important parasitic diseases threatening hundreds of million human beings worldwide. As they diverged early in evolution, they display original molecular characteristics. These peculiarities are each defining putative specific targets for anti-parasitic drugs. Transcription displays its lot of unique characteristics in trypanosomes and will be taken as an example to uncover these targets. Unique features of transcription in trypanosomes include constitutive and poly-cistronic transcription by RNA polymerase II as well as transcription of protein-coding genes by RNA polymerase I. It is becoming clear that these unique mechanisms are performed by dedicated molecular players. The first of them have been recently characterized. They are reviewed and their suitability as drug targets is commented.
Vanhamme
Luc
L
Laboratoire de Parasitologie Moléculaire, Institut de Biologie et Médecine Moléculaire (IBMM), Université Libre de Bruxelles (ULB), 12 rue des Professeurs Jeener et Brachet, 6041 Gosselies, Belgium. luc.vanhamme@ulb.ac.be
D000818:Animals; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D008954:Models, Biological; D011528:Protozoan Infections / Q000188:drug therapy* / Q000469:parasitology; D014157:Transcription Factors / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D014344:Trypanocidal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D014345:Trypanosoma / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*
D014157:Transcription Factors; D014344:Trypanocidal Agents; D012321:DNA-Directed RNA Polymerases