Effect of a neuraminidase inhibitor (oseltamivir) on mouse jump-down behavior via stimulation of dopamine receptors.
Oseltamivir (Tamiflu, Roche Laboratories, Inc.) is a neuraminidase inhibitor that can cause jumpdown behaviors in children. There is a mouse slip-down model, in which the dopamine D2 receptor activity is increased by serum sialoglycolipids and the mouse jump-down behavior appears in response to the dopamine D2 receptor agonist, PPHT. The present study examined the effect of oseltamivir on jump-down behavior in mice. Oseltamivir sialylates a serum glycolipid and this modified glycolipid induces jump-down behavior via the stimulation of dopamine D2 receptors. This mechanism may be involved in the abnormal behavior of children taking oseltamivir.
Suzuki
Minoru
M
Department of Neuropsychiatry, Akita University School of Medicine, Akita, Japan. suzukimi@kyusei.or.jp
Masuda
Yutaka
Y
D000293:Adolescent; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002648:Child; D018491:Dopamine Agonists / Q000378:metabolism / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000378:metabolism / Q000494:pharmacology; D006017:Glycolipids / Q000097:blood; D006801:Humans; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D053139:Oseltamivir / Q000378:metabolism / Q000494:pharmacology; D010627:Phenethylamines / Q000378:metabolism / Q000494:pharmacology; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D055815:Young Adult
D018491:Dopamine Agonists; D004791:Enzyme Inhibitors; D006017:Glycolipids; D010627:Phenethylamines; D017448:Receptors, Dopamine D2; C009255:sialoglycolipids; D053139:Oseltamivir; C041369:2-(N-phenethyl-N-propyl)amino-5-hydroxytetralin; D009439:Neuraminidase