title: Lacticin Q, a lactococcal bacteriocin, causes high-level membrane permeability in the absence of specific receptors.
abstract: To characterize the mode of action of lacticin Q (LnqQ), its membrane-permeabilizing activity was compared with that of nisin A because of the similar antimicrobial features of these compounds. Lipid II, the receptor for nisin A, was not required for LnqQ activity. LnqQ induced high-level membrane permeability in the absence of specific receptors.
authors.affiliation: Laboratory of Microbial Technology, Division of Microbial Science and Technology, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka 812-8581, Japan.
authors.forename: Fuminori
authors.initials: F
authors.lastname: Yoneyama
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Imura
authors.forename: Shiro
authors.initials: S
authors.lastname: Ichimasa
authors.forename: Koji
authors.initials: K
authors.lastname: Fujita
authors.forename: Takeshi
authors.initials: T
authors.lastname: Zendo
authors.forename: Jiro
authors.initials: J
authors.lastname: Nakayama
authors.forename: Katsumi
authors.initials: K
authors.lastname: Matsuzaki
authors.forename: Kenji
authors.initials: K
authors.lastname: Sonomoto
mesh_terms: D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001430:Bacteriocins / Q000737:chemistry / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects*; D009561:Nisin / Q000494:pharmacology; D010539:Permeability / Q000187:drug effects*; D017433:Protein Structure, Secondary
chemical_list: D000900:Anti-Bacterial Agents; D001430:Bacteriocins; D009561:Nisin; C102526:nisin A