title: Acute hepatitis E in south-west France over a 5-year period.
abstract: BACKGROUND
  Hepatitis E was found in people living in industrialized countries who had not travelled to highly endemic areas.
  
  
  OBJECTIVE
  To study the cases of acute hepatitis E confirmed thanks to viral genomic detection over a 5 years period in south-west France.
  
  
  METHODS
  62 cases of hepatitis E were identified between 2003 and 2007. Their demographic, clinical, and virological features were analyzed.
  
  
  RESULTS
  Cases of acute hepatitis E occurred regularly throughout this period. No seasonal variation was found. Patients, usually male (sex ratio=1.95), were adults living in both urban and rural areas. Sixty (96.8%) patients had not travelled abroad during the 6 months before diagnosis. Clinical manifestations ranged from asymptomatic infection to severe hepatitis. HEV was genotyped in 55 specimens. All the patients who had not travelled abroad were infected with genotype 3.
  
  
  CONCLUSIONS
  The incidence of hepatitis E in south-west France was stable from 2003 to 2007, 96.8% of the cases were autochthonous. There was an age-related increase in the disease and patients tended to be men. The predominant genotype and subtype was 3f. However, contaminations pathways involved in hepatitis E in our area remain to clarify.
authors.affiliation: CHU Toulouse, Hôpital Purpan, Laboratoire de virologie, Institut fédératif de biologie de Purpan, F-31300, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Mansuy
authors.forename: F
authors.initials: F
authors.lastname: Abravanel
authors.forename: M
authors.initials: M
authors.lastname: Miedouge
authors.forename: C
authors.initials: C
authors.lastname: Mengelle
authors.forename: C
authors.initials: C
authors.lastname: Merviel
authors.forename: M
authors.initials: M
authors.lastname: Dubois
authors.forename: N
authors.initials: N
authors.lastname: Kamar
authors.forename: L
authors.initials: L
authors.lastname: Rostaing
authors.forename: L
authors.initials: L
authors.lastname: Alric
authors.forename: J
authors.initials: J
authors.lastname: Moreau
authors.forename: J M
authors.initials: JM
authors.lastname: Peron
authors.forename: J
authors.initials: J
authors.lastname: Izopet
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005602:France / Q000453:epidemiology; D005838:Genotype; D016751:Hepatitis E / Q000453:epidemiology* / Q000473:pathology / Q000503:physiopathology; D016752:Hepatitis E virus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D012424:Rural Population; D012621:Seasons; D012737:Sex Factors; D014505:Urban Population; D055815:Young Adult
chemical_list: D012367:RNA, Viral