title: Development of functional lab-on-a-chip on polymer for point-of-care testing of metabolic parameters.
abstract: This paper presents the development of an easy-to-handle and disposable clinical diagnostic lab-on-a-chip using fully integrated plastic microfluidic components, which has the sampling/identifying capability to make fast and reliable measurements of metabolic parameters from human whole blood. A smart and functional lab-on-a-chip cartridge, which incorporates a full on-chip auto-calibration function for in the field applications, has been developed, and then fully characterized using a portable analyzer (3 (1/4)''x 5''x 1'') with multi-analyte detection capability. In addition, several new approaches in realizing smart and functional lab-on-a-chips on polymer have been adopted, which include the pinch valve for automatic fluidic sealing, a by-pass channel as the sampling indicator, and a robust connector design for long analyzer lifetimes. Metabolic parameters such as glucose, lactate, and partial oxygen from human whole blood have been successfully measured using the functional polymer lab-on-a-chips and the portable analyzer developed in this work.
authors.affiliation: Electrical and Computer Engineering, University of Cincinnati, Cincinnati, OH 45221, USA. dowooner@hotmail.com
authors.forename: Jaephil
authors.initials: J
authors.lastname: Do
authors.forename: Sehwan
authors.initials: S
authors.lastname: Lee
authors.forename: Jungyup
authors.initials: J
authors.lastname: Han
authors.forename: Junhai
authors.initials: J
authors.lastname: Kai
authors.forename: Chien-Chong
authors.initials: CC
authors.lastname: Hong
authors.forename: Chuan
authors.initials: C
authors.lastname: Gao
authors.forename: Joseph H
authors.initials: JH
authors.lastname: Nevin
authors.forename: Gregory
authors.initials: G
authors.lastname: Beaucage
authors.forename: Chong H
authors.initials: CH
authors.lastname: Ahn
mesh_terms: D001774:Blood Chemical Analysis; D001786:Blood Glucose / Q000737:chemistry; D056656:Lab-On-A-Chip Devices; D007773:Lactates / Q000737:chemistry; D019344:Lactic Acid / Q000737:chemistry; D046208:Microchip Analytical Procedures / Q000379:methods*; D019095:Point-of-Care Systems
chemical_list: D001786:Blood Glucose; D007773:Lactates; D019344:Lactic Acid