title: Prediction of key factor controlling G1/S phase in the mammalian cell cycle using system analysis.
abstract: Control of the G1/S phase transition of the cell cycle contributes to the maintenance of homeostasis. It is well known that the disruption of the cell cycle is related to cell transformation and carcinogenesis. The G1/S phase transition involves a network of components that includes cyclins, cyclin-dependent kinases, and other proteins. Numerical simulation techniques and system analysis are expected to become powerful tools for investigating complex biological networks. To reach this goal, we designed a mathematical model of the G1/S phase transition. Using our model, we conducted a numerical simulation and comprehensive system analyses of this phase of the cell cycle. In this way, we were able to predict the key factors involved in the control of the G1/S transition.
authors.affiliation: Laboratory for Bioinformatics, Graduate School of Systems Life Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Tashima
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hamada
authors.forename: Masahiro
authors.initials: M
authors.lastname: Okamoto
authors.forename: Taizo
authors.initials: T
authors.lastname: Hanai
mesh_terms: D000818:Animals; D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000378:metabolism; D002471:Cell Transformation, Neoplastic; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D016193:G1 Phase; D006801:Humans; D007700:Kinetics; D020935:MAP Kinase Signaling System; D008954:Models, Biological; D008962:Models, Theoretical; D010766:Phosphorylation; D016196:S Phase; D049490:Systems Biology; D013997:Time Factors
chemical_list: D018797:Cell Cycle Proteins; D018844:Cyclin-Dependent Kinases