Vasorelaxant effects of forsythide isolated from the leaves of Forsythia viridissima on NE-induced aortal contraction.
Forsythide (F1) isolated from the leaves of Forsythia viridissima (Oleaceae) showed vasorelaxant effects on norepinephrine (NE)-induced contraction of rat aorta with or without endothelium. This compound did not affect contraction induced by high concentration potassium (60 mM K(+)) and phorbol 12,13-diacetate, but inhibited NE-induced contraction in the presence of nicardipine. These results demonstrated the inhibitory effects of F1 on NE-induced vasocontraction presumably due to decrease of calcium influx from extracellular area, which was induced by NE.
Iizuka
T
T
Laboratory of Pharmacognosy, Yokohama College of Pharmacy, Matano-cho 601, Tozuka-ku, Yokohama, Kanagawa 245-0066, Japan. t.iizuka@hamayaku.ac.jp
Sakai
H
H
Moriyama
H
H
Suto
N
N
Nagai
M
M
Bagchi
D
D
D000818:Animals; D001011:Aorta / Q000187:drug effects; D002118:Calcium / Q000494:pharmacology; D031657:Forsythia; D006574:Heterocyclic Compounds, 2-Ring / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D009005:Monosaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D009126:Muscle Relaxation / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D010703:Phorbol Esters / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology*
D006574:Heterocyclic Compounds, 2-Ring; D009005:Monosaccharides; D010703:Phorbol Esters; D010936:Plant Extracts; D014665:Vasodilator Agents; C540611:forsythide; C008874:phorbol-12,13-diacetate; D011188:Potassium; D002118:Calcium; D009638:Norepinephrine