title: Left atrial remodelling in patients with myocardial infarction complicated by heart failure, left ventricular dysfunction, or both: the VALIANT Echo study.
abstract: OBJECTIVE
  To assess the relationship between left atrial (LA) size and outcome after high-risk myocardial infarction (MI) and to study dynamic changes in LA size during long-term follow-up.
  
  
  RESULTS
  The VALIANT Echocardiography study prospectively enrolled 610 patients with left ventricular (LV) dysfunction, heart failure (HF), or both following MI. We assessed LA volume indexed to body surface area (LAVi) at baseline, 1 month, and 20 months after MI. Baseline LAVi was an independent predictor of all-cause death or HF hospitalization (P = 0.004). In patients who survived to 20 months, LAVi increased a mean of 3.00 +/- 7.08 mL/m(2) from baseline. Hypertension, lower estimated glomerular filtration rate, and LV mass were the only baseline independent predictors of LA remodelling. Changes in LA size were related to worsening in MR and increasing in LV volumes. LA enlargement during the first month was significantly greater in patients who subsequently died or were hospitalized for HF than in patients without events.
  
  
  CONCLUSIONS
  Baseline LA size is an independent predictor of death or HF hospitalization following high-risk MI. Moreover, LA remodelling during the first month after infarction is associated with adverse outcome.
authors.affiliation: Cardiovascular Division, Brigham and Women's Hospital, MA, USA.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Meris
authors.forename: Maria
authors.initials: M
authors.lastname: Amigoni
authors.forename: Hajime
authors.initials: H
authors.lastname: Uno
authors.forename: Jens Jakob
authors.initials: JJ
authors.lastname: Thune
authors.forename: Anil
authors.initials: A
authors.lastname: Verma
authors.forename: Lars
authors.initials: L
authors.lastname: Køber
authors.forename: Mikhail
authors.initials: M
authors.lastname: Bourgoun
authors.forename: John J
authors.initials: JJ
authors.lastname: McMurray
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Velazquez
authors.forename: Aldo P
authors.initials: AP
authors.lastname: Maggioni
authors.forename: Jalal
authors.initials: J
authors.lastname: Ghali
authors.forename: J Malcolm O
authors.initials: JM
authors.lastname: Arnold
authors.forename: Steven
authors.initials: S
authors.lastname: Zelenkofske
authors.forename: Marc A
authors.initials: MA
authors.lastname: Pfeffer
authors.forename: Scott D
authors.initials: SD
authors.lastname: Solomon
mesh_terms: D000368:Aged; D016279:Atrial Function, Left; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006325:Heart Atria / Q000000981:diagnostic imaging*; D006333:Heart Failure / Q000150:complications* / Q000000981:diagnostic imaging / Q000401:mortality; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000000981:diagnostic imaging / Q000401:mortality; D053208:Kaplan-Meier Estimate; D007676:Kidney Failure, Chronic / Q000150:complications / Q000000981:diagnostic imaging / Q000401:mortality; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000000981:diagnostic imaging* / Q000401:mortality; D011379:Prognosis; D011446:Prospective Studies; D018487:Ventricular Dysfunction, Left / Q000150:complications* / Q000000981:diagnostic imaging / Q000401:mortality