title: Xanthones from Polygala alpestris (Rchb.).
abstract: Bioactivity-guided fractionation of Polygala alpestris L. (Rchb.) extracts led to the identification of two new xanthones, 1,3,7-trihydroxy-2,6-dimethoxyxanthone (1) and 2,3-methylenedioxy-4,7-dihydroxyxanthone (2). In addition five known compounds 3,4-dimethoxy-1,7-dihydroxyxanthone (3), 1,3-dihydroxy-7-methoxyxanthone (4), 1,7-dihydroxy-2,3-dimethoxyxanthone (5), 3',6-O-disinapoyl sucrose (6) and 3',5'-dimethoxybiphenyl-4-olo (7) were isolated. The structures of the isolated compounds were established by means of high resolution mass spectrometry, mono- and bi-dimensional NMR spectroscopy. All isolated compounds were tested for cytotoxic activity against three tumor cell lines (LoVo, HL-60, K 562).
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università degli Studi di Padova, Padova, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Dall'Acqua
authors.forename: Giampietro
authors.initials: G
authors.lastname: Viola
authors.forename: Elsa Mariella
authors.initials: EM
authors.lastname: Cappelletti
authors.forename: Gabbriella
authors.initials: G
authors.lastname: Innocenti
mesh_terms: D000230:Adenocarcinoma; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor / Q000187:drug effects; D018922:HL-60 Cells / Q000187:drug effects; D006801:Humans; D020014:K562 Cells / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D035261:Plant Components, Aerial / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D031801:Polygala / Q000737:chemistry*; D013053:Spectrophotometry; D044004:Xanthones / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D044004:Xanthones