Klebsiella pneumoniae OmpA confers resistance to antimicrobial peptides.
A Klebsiella pneumoniae ompA mutant was more susceptible to antimicrobial peptides (APs) than the wild type. Susceptibility did not result from surface changes other than the absence of OmpA. Our data suggest that OmpA is implicated in the activation of yet-unknown systems dedicated to ameliorating AP cytotoxicity.
Llobet
Enrique
E
Program Infection and Immunity, Fundación Caubet-CIMERA Illes Balears, Centro Investigación Biomédica en Red de Enfermedades Respiratorias, Bunyola, Spain.
March
Catalina
C
Giménez
Paloma
P
Bengoechea
José A
JA
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000494:pharmacology*; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000502:physiology*; D004351:Drug Resistance / Q000235:genetics; D004591:Electrophoresis, Polyacrylamide Gel; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000235:genetics*; D009154:Mutation
D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D001425:Bacterial Outer Membrane Proteins; C078167:OMPA outer membrane proteins