A robust strategy for the preparation of libraries of metallopeptides. A new paradigm for the discovery of targeted molecular imaging and therapy agents.
A robust method for synthesizing structurally diverse metallopeptide libraries using a Re(i) complex of a non-natural amino acid was developed as a way to accelerate the discovery of novel molecular imaging probes.
Armstrong
Andrea F
AF
Department of Chemistry, McMaster University, Hamilton, ON, Canada.
Oakley
Nick
N
Parker
Shannon
S
Causey
Patrick W
PW
Lemon
Jennifer
J
Capretta
Alfredo
A
Zimmerman
Craig
C
Joyal
John
J
Appoh
Francis
F
Zubieta
Jon
J
Babich
John W
JW
Singh
Gurmit
G
Valliant
John F
JF
D003952:Diagnostic Imaging / Q000639:trends; D008024:Ligands; D008667:Metalloproteins / Q000138:chemical synthesis* / Q000737:chemistry; D015336:Molecular Probe Techniques / Q000639:trends; D015335:Molecular Probes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D019151:Peptide Library; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D012211:Rhenium / Q000737:chemistry; D013237:Stereoisomerism
D008024:Ligands; D008667:Metalloproteins; D015335:Molecular Probes; D019151:Peptide Library; D010455:Peptides; D012211:Rhenium