title: [Allotransplantation of Leydig cells increases serum testosterone in rats].
abstract: OBJECTIVE
  To observe the changes of serum testosterone after allotransplantation of Leydig cells in rats.
  
  
  METHODS
  Leydig cells were isolated from the testes of SD rats with the Percoll technique and serum testosterone of the receptors was determined once a month for 3 successive times.
  
  
  RESULTS
  After allotransplantation of Leydig cells, the serum testosterone level of the receptors increased gradually, significantly higher at 3 months than that of the normal rats younger than 2 months old.
  
  
  CONCLUSIONS
  Allotransplantation of Leydig cells has a promising application value in the treatment of male primary hypogonadism.
authors.affiliation: Department of Surgery, Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200127, China. ppdrsun@gmail.com
authors.forename: Jie
authors.initials: J
authors.lastname: Sun
authors.forename: Cheng-Ren
authors.initials: CR
authors.lastname: Shi
authors.forename: Ye-Bin
authors.initials: YB
authors.lastname: Xi
authors.forename: Wei-Yi
authors.initials: WY
authors.lastname: Li
authors.forename: Huai-Yuan
authors.initials: HY
authors.lastname: Li
mesh_terms: D000818:Animals; D017690:Cell Transplantation; D007985:Leydig Cells / Q000166:cytology / Q000637:transplantation*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013739:Testosterone / Q000097:blood*
chemical_list: D013739:Testosterone