A comparison of the biological properties of small molecular weight agonists and antagonists of CD200:CD200R interactions.
Our laboratory and others have documented in some detail the immunological consequences which follow from interaction of the ubiquitously expressed molecule CD200 with its receptor(s) CD200R (expressed predominantly on cells of myeloid and lymphoid origin). In particular, there is evidence that these interactions lead to immunosuppressive signals which modulate graft rejection responses; decrease the manifestations of arthritis in rodent models; diminish mast cell mediator release in models of allergic disease; and favour the growth of tumors in both mice and humans. The development of small molecular weight agonists (and/or antagonists) of these interactions would thus likely have significant clinical importance. The data reported herein characterizes several such molecules in a number of rodent models.
Gorczynski
Reg
R
Transplant Research Division, Toronto Hospital and University Health Network, Toronto, Ontario, Canada. reg.gorczynski@utoronto.ca
Boudakov
Ivo
I
Khatri
Ismat
I
D000595:Amino Acid Sequence; D000818:Animals; D015703:Antigens, CD / Q000187:drug effects*; D001854:Bone Marrow Cells / Q000187:drug effects; D016466:CHO Cells; D002470:Cell Survival / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus; D005260:Female; D006084:Graft Rejection / Q000517:prevention & control; D007166:Immunosuppressive Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008562:Membrane Glycoproteins / Q000819:agonists* / Q000037:antagonists & inhibitors*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008970:Molecular Weight; D010455:Peptides / Q000138:chemical synthesis / Q000494:pharmacology; D016038:Skin Transplantation / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000187:drug effects
D015703:Antigens, CD; C492346:CD200 receptor, mouse; D007166:Immunosuppressive Agents; D008070:Lipopolysaccharides; D008562:Membrane Glycoproteins; D010455:Peptides; C042739:antigens, CD200