title: Antimalarial compounds from the root bark of Garcinia polyantha Olv.
abstract: Eight compounds were isolated from the roots of Garcinia polyantha, and identified. Two of them, the xanthone garciniaxanthone I (1), and the triterpene, named garcinane (2), are reported as new natural products. The structures of the new compounds were elucidated on the basis of 1D and 2D NMR spectroscopic studies. The structure of compound 1 was confirmed by X-ray crystallography. Among the remaining six known compounds, three were known xanthones [smeathxanthone A (3), smeathxanthone B (4), and chefouxanthone (5)], one benzophenone [isoxanthochymol (6)], one triterpene [magnificol], and one sterol [beta-sitosterol]. The in vitro antimalarial activity of isoxanthochymol (6) against Plasmodium falciparum shows strong chemosuppression of parasitic growth.
authors.affiliation: Department of Organic Chemistry, University of Yaoundé I, Cameroon.
authors.forename: Alain Meli
authors.initials: AM
authors.lastname: Lannang
authors.forename: Gabin Nselapi
authors.initials: GN
authors.lastname: Louh
authors.forename: David
authors.initials: D
authors.lastname: Lontsi
authors.forename: Sabine
authors.initials: S
authors.lastname: Specht
authors.forename: Salem Ramadan
authors.initials: SR
authors.lastname: Sarite
authors.forename: Ulrich
authors.initials: U
authors.lastname: Flörke
authors.forename: Hidayat
authors.initials: H
authors.lastname: Hussain
authors.forename: Achim
authors.initials: A
authors.lastname: Hoerauf
authors.forename: Karsten
authors.initials: K
authors.lastname: Krohn
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D029760:Garcinia / Q000737:chemistry*; D016778:Malaria, Falciparum / Q000469:parasitology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009904:Optical Rotation; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000302:isolation & purification; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000962:Antimalarials; D010936:Plant Extracts; D014315:Triterpenes; D044004:Xanthones