[Molecular-genetic and epidemiologic examination of personnel subjected to occupational irradiation in Russian Federal Nuclear Center (Sarov). Report 1. Genome structural damage rate and radiosensitivity].
A comparative evaluation of the cytological and dosimetric examination of the cohort comprised by VNIEF personnel subjected chronically to gamma-neutron ionizing radiation, as well as non-irradiated cohort is given. The obtained data on the influence of the occupational and on X-ray irradiation, age and smoking on the rate of structural genome damage, as well as the activity of the human repair system activity are presented. The influence of the individual heterozygosis by 9 polymorphous loci: Hp, Tf, Gc; 6-PGD, EsD, ACP, PGM1, microsatellite lici SCF1PO and F13AO1 is shown.
Korzeneva
I B
IB
Zaichkina
S I
SI
Malinina
T V
TV
Afanas'ev
K I
KI
Dubrova
Iu E
IuE
Skorodumova
E N
EN
Samsonova
V F
VF
Volkova
I V
IV
Shishova
R T
RT
Shcherbakova
I L
IL
D000047:Academies and Institutes; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D015331:Cohort Studies; D003627:Data Interpretation, Statistical; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays / Q000009:adverse effects*; D005787:Gene Frequency; D042822:Genomic Instability / Q000528:radiation effects*; D006579:Heterozygote; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects; D008297:Male; D048629:Micronuclei, Chromosome-Defective / Q000528:radiation effects*; D015162:Micronucleus Tests; D008875:Middle Aged; D009686:Nuclear Physics; D016273:Occupational Exposure / Q000009:adverse effects / Q000032:analysis / Q000592:standards; D011832:Radiation Injuries / Q000453:epidemiology / Q000209:etiology / Q000235:genetics; D011836:Radiation Tolerance / Q000235:genetics / Q000528:radiation effects; D012426:Russia; D013997:Time Factors; D055815:Young Adult