title: Vault-related resistance to anticancer drugs determined by the expression of the major vault protein LRP.
abstract: In this review we analyze the data supporting the notion that vault-related MDR, as reflected by LRP/MVP overexpression, represents a marker of drug resistance in vitro and in the clinic. Vaults, besides playing a fundamental biological role, may be involved in a novel mechanism of MDR.
authors.affiliation: Department of Medical Oncology, Catalan Institute of Oncology, Av. Casteldefels Km 2.7, 08907 Hospitalet de LI., Barcelona, Spain.
authors.forename: M A
authors.initials: MA
authors.lastname: Izquierdo
authors.forename: G L
authors.initials: GL
authors.lastname: Scheffer
authors.forename: A B
authors.initials: AB
authors.lastname: Schroeijers
authors.forename: M C
authors.initials: MC
authors.lastname: de Jong
authors.forename: R J
authors.initials: RJ
authors.lastname: Scheper