title: [Epiphora in a patient receiving FOLFOX therapy].
abstract: A 75-year-old patient with colorectal cancer was treated by FOLFOX4 therapy. When the total dose of 5-fluorouracil reached 21,200 mg and the total dose of oxaliplatin reached 880 mg after about 100 days of treatment, epiphora developed. Because the pharmacist discovered it soon, he could consult with an ophthalmologist, and the man was diagnosed with subconjunctival hemorrhage. Thereafter, the symptom improved with ofloxacin eye drops. Attention must be paid to the visual side effect in case an anticancer agent is used and when aggressive involvement of the pharmacist in medical team treatment is expected.
authors.affiliation: Dept. of Pharmacy, Kumamoto Rosai Hospital.
authors.forename: Chiaki
authors.initials: C
authors.lastname: Yatsuda
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Niimi
authors.forename: Yukari
authors.initials: Y
authors.lastname: Ono
authors.forename: Naoya
authors.initials: N
authors.lastname: Uto
authors.forename: Eiichi
authors.initials: E
authors.lastname: Iwagami
authors.forename: Eiji
authors.initials: E
authors.lastname: Tanaka
authors.forename: Masaaki
authors.initials: M
authors.lastname: Yamato
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use*; D005472:Fluorouracil / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007766:Lacrimal Apparatus Diseases / Q000139:chemically induced*; D002955:Leucovorin / Q000009:adverse effects / Q000627:therapeutic use; D008113:Liver Neoplasms / Q000097:blood / Q000188:drug therapy / Q000556:secondary; D008297:Male; D009944:Organoplatinum Compounds / Q000009:adverse effects / Q000627:therapeutic use; D012004:Rectal Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
chemical_list: D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil