Dihydropyrazolopyrimidine inhibitors of K(V)1.5 (I(Kur)).
A series of dihydropyrazolopyrimidine inhibitors of K(V)1.5 (I(Kur)) have been identified. The synthesis, structure-activity relationships and selectivity against several other ion channels are described.
Vaccaro
Wayne
W
Bristol-Myers Squibb, Route 206 & Provinceline Road, PO Box 4000, Princeton, NJ 08543-4000, USA. wayne.vaccaro@bms.com
Huynh
Tram
T
Lloyd
John
J
Atwal
Karnail
K
Finlay
Heather J
HJ
Levesque
Paul
P
Conder
Mary Lee
ML
Jenkins-West
Tonya
T
Shi
Hong
H
Sun
Lucy
L
D000818:Animals; D001281:Atrial Fibrillation / Q000378:metabolism; D002460:Cell Line; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D006801:Humans; D007477:Ions / Q000737:chemistry; D051379:Mice; D008956:Models, Chemical; D026902:Potassium Channel Blockers / Q000138:chemical synthesis* / Q000494:pharmacology; D024642:Potassium Channels, Voltage-Gated / Q000037:antagonists & inhibitors*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D007477:Ions; D026902:Potassium Channel Blockers; D024642:Potassium Channels, Voltage-Gated; D011743:Pyrimidines