title: Evolution of PTLD following renal transplantation in a child.
abstract: We report the case of an eight-yr-old child with early onset PTLD half a year after renal transplantation. The patient developed gastrointestinal pain and bowel biopsies revealed imposing lymphoid infiltrates with small spots of lymphoid blasts in the colonic mucosa. These findings were interpreted as transplantation associated B-cell stimulation. However, the persistent severe abdominal pain led to the resection of a jejunal segment. Here, gut wall perforation caused by a tumor mass was seen. Histologically, a blastic lymphoid cell proliferation of B-cell origin with high proliferation rate and EBV association could be demonstrated. IgH rearrangement analysis and in situ hybridization revealed an oligoclonal B-cell pattern. Reduction of immunosuppression and treatment with rituximab led to lymphoma remission and conversion of EBV serology four wk later. The report presented herein demonstrates the evolution of an oligoclonal lymphoproliferation with direct disease progression towards EBV associated PTLD by analyzing different stages of the disease.
authors.affiliation: Institute of Pathology, University of Cologne 50924 Cologne, Germany.
authors.forename: Eva
authors.initials: E
authors.lastname: Markert
authors.forename: Udo
authors.initials: U
authors.lastname: Siebolts
authors.forename: Sandra
authors.initials: S
authors.lastname: Habbig
authors.forename: Margarete
authors.initials: M
authors.lastname: Odenthal
authors.forename: Hans Peter
authors.initials: HP
authors.lastname: Dienes
authors.forename: Dirk L
authors.initials: DL
authors.lastname: Stippel
authors.forename: Bernd
authors.initials: B
authors.lastname: Hoppe
authors.forename: Claudia
authors.initials: C
authors.lastname: Wickenhauser
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002648:Child; D018450:Disease Progression; D020031:Epstein-Barr Virus Infections / Q000276:immunology / Q000503:physiopathology*; D004854:Herpesvirus 4, Human; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D016030:Kidney Transplantation / Q000009:adverse effects*; D008232:Lymphoproliferative Disorders / Q000188:drug therapy / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D000069283:Rituximab; D019562:Viral Load
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D000069283:Rituximab