[The role of lactoferrin in the iron metabolism. Part I. Effect of lactofferin on intake, transport and iron storage].
Iron belongs to the most widely distributed elements and is essential for the metabolism of almost all organisms. It is required for enzymatic reactions, in particular of those involving electron transport. It also participates in the transport and storage of oxygen in tissues. Iron is present in hem-containing proteins (hemoproteins) such as: hemoglobin, myoglobin, cytochromes,cytochrome oxidases, catalases and peroxidases. It is also a constituent of proteins which do not contain hem molecule: flavoproteins (succinate and NADH dehydrogenase) and of mitochondrial aconitase. In addition, iron takes part in many metabolic processes, among others in synthesis and catabolism of some hormones, synthesis of high-energy compounds and collagen, detoxification processes and immune reactions. It also participates in formation of reactive oxygen species which may exhibit both beneficial and harmful effects. Iron occurs in aqueous solutions as ferric (Fe+++) and ferrous (Fe++) ion. Although Fe+++ is hardly soluble, the organisms evolved mechanisms allowing to acquire and utilize that element irrespectively of its valency. The iron metabolism encompasses: intake, transport, participation in metabolism and storage. The iron metabolism undergoes in a closed cycle; in the physiological state only small amount of this metal is absorbed in the alimentary duct and disposed from the organism. A number of proteins is involved in iron metabolism including: ferritin, transferrin,transferrin receptor, divalent metal transporter (DMT1), cytochrome b, ferroportin, hephaestin, hepcidin and lactoferrin (LF). A beneficial effect of LF on iron acquisition in the gut is best documented.That process involves a receptor-mediated absorption of iron-bound LF through intestinal epithelial cells. The role of LF in transfer of iron from maternal milk may be of utmost importance. Many observations indicate also that LF participates in the process of iron storage,predominantly in the liver. Contradictory data exist, however, regarding the role of LF in iron transport to other cell types and organs.
Artym
Jolanta
J
Zakład Terapii Doświadczalnej, Instytut Immunologii i Terapii Doświadczalnej PAN im. L.Hirszfelda, Wrocław. limbiol@iitd.pan.wroc.pl
D018798:Anemia, Iron-Deficiency / Q000188:drug therapy / Q000378:metabolism; D000818:Animals; D005293:Ferritins / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption; D007501:Iron / Q000378:metabolism*; D007502:Iron Chelating Agents / Q000378:metabolism; D007781:Lactoferrin / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008895:Milk, Human / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D014168:Transferrin / Q000378:metabolism
D007502:Iron Chelating Agents; D017382:Reactive Oxygen Species; D014168:Transferrin; D005293:Ferritins; D007501:Iron; D007781:Lactoferrin