title: Tandem addition-cyclization reactions of 2-alkynylbenzenamines with isocyanates catalyzed by PdCl2.
abstract: Tandem addition-cyclization reactions of 2-alkynylbenzenamines with isocyanates catalyzed by palladium chloride are described. This reaction is performed in the presence of 10 mol% of palladium chloride in THF at 80 degrees C, which provides an efficient and practical route for the synthesis of 1,2-disubstituted indoles.
authors.affiliation: Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, China.
authors.forename: Shengqing
authors.initials: S
authors.lastname: Ye
authors.forename: Qiuping
authors.initials: Q
authors.lastname: Ding
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Wang
authors.forename: Haibo
authors.initials: H
authors.lastname: Zhou
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
mesh_terms: D000588:Amines / Q000737:chemistry*; D001554:Benzene / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D017953:Isocyanates / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D000588:Amines; D017953:Isocyanates; D010165:Palladium; D001554:Benzene; C008756:palladium chloride