title: Design, synthesis, and biological evaluation of a scaffold for iGluR ligands based on the structure of (-)-kaitocephalin.
abstract: The design and synthesis of four pyrrolidine scaffolds that are structurally related to the known ionotropic glutamate receptor antagonist, (-)-kaitocephalin, is described. Additionally, preliminary results of the biological evaluation of these compounds are disclosed.
authors.affiliation: Department of Chemistry, University of California at Irvine, Irvine, CA 92697, USA.
authors.forename: Rishi G
authors.initials: RG
authors.lastname: Vaswani
authors.forename: Agenor
authors.initials: A
authors.lastname: Limon
authors.forename: Jorge Mauricio
authors.initials: JM
authors.lastname: Reyes-Ruiz
authors.forename: Ricardo
authors.initials: R
authors.lastname: Miledi
authors.forename: A Richard
authors.initials: AR
authors.lastname: Chamberlin
mesh_terms: D015195:Drug Design; D018690:Excitatory Amino Acid Agonists / Q000737:chemistry; D018691:Excitatory Amino Acid Antagonists / Q000737:chemistry; D006801:Humans; D008024:Ligands; D011758:Pyrroles / Q000737:chemistry*; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000494:pharmacology; D017470:Receptors, Glutamate / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists; D008024:Ligands; D011758:Pyrroles; D011759:Pyrrolidines; D017470:Receptors, Glutamate; C442421:kaitocephalin