title: Isomeric furanosesquiterpenes from the Portuguese marine sponge Fasciospongia sp.
abstract: This paper reports the chemical study of a sample of Fasciospongia sp. collected along the Atlantic Portuguese coast. Three new isomeric furanosesquiterpenes, isomicrocionin-3 ( 1), (-)-microcionin-1 ( 2), and (-)-isomicrocionin-1 ( 3), were isolated along with the known (-)- ent-pallescensin A ( 4) and (-)-pallescensin-1 ( 5) from the ethyl acetate-soluble portion of the methanolic extract. The structures of the new compounds were elucidated by extensive spectroscopic studies. (-)-Microcionin-1 ( 2) tested positive against several Gram-negative bacteria.
authors.affiliation: helena.gaspar@ineti.pt.
authors.forename: Helena
authors.initials: H
authors.lastname: Gaspar
authors.forename: Susana
authors.initials: S
authors.lastname: Santos
authors.forename: Mariana
authors.initials: M
authors.lastname: Carbone
authors.forename: Ana Isabel
authors.initials: AI
authors.lastname: Rodrigues
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Uriz
authors.forename: Sónia Murta
authors.initials: SM
authors.lastname: Savluchinske Feio
authors.forename: Dominique
authors.initials: D
authors.lastname: Melck
authors.forename: Madalena
authors.initials: M
authors.lastname: Humanes
authors.forename: Margherita
authors.initials: M
authors.lastname: Gavagnin
mesh_terms: D000818:Animals; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification*; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D011174:Portugal; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism
chemical_list: D005663:Furans; D012717:Sesquiterpenes; C000604850:isomicrocionin-1; C000604849:isomicrocionin-3; C000604895:microcionin-1