title: Endurance training attenuates the oxidative stress due to acute exhaustive exercise in rat liver.
abstract: The aim of this study was to investigate whether an 8-week treadmill training attenuates exercise-induced oxidative stress in rat liver. Male rats were divided into untrained and trained groups. Endurance training consisted of treadmill running at a speed of 2.1 km/h, 1.5 h/day, 5 days a week for 8 weeks. To see the effects of endurance training on acute exhaustive exercise induced oxidative stress, untrained and trained rats were further devided into two groups: animals killed at rest and those killed after acute exhaustive exercise, in which the rats run at 2.1 km/h (10% uphill) until exhaustion. Acute exhaustive exercise increased malondialdehyde level in untrained but not in trained rats. It decreased the activity of glutathione peroxidase and total (enzymatic plus non-enzymatic) superoxide scavenger activity in untrained rats and catalase activity in trained rats. However, it did not affect glutathione S-transferase, glutathione reductase, superoxide dismutase and non-enzymatic superoxide radical scavenger activities in both trained and untrained rats. On the other hand, endurance training decreased glutathione peroxidase and glutathione S-transferase activities. The results suggested that endurance training attenuated exercise-induced oxidative stress in liver, probably by preventing the decreases in glutathione peroxidase and total superoxide scavenger activities during exercise.
authors.affiliation: Department of Biochemistry and Clinical Biochemistry, University of Gaziantep, Faculty of Medicine, Gaziantep, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Taysi
authors.forename: N
authors.initials: N
authors.lastname: Oztasan
authors.forename: H
authors.initials: H
authors.lastname: Efe
authors.forename: M F
authors.initials: MF
authors.lastname: Polat
authors.forename: K
authors.initials: K
authors.lastname: Gumustekin
authors.forename: E
authors.initials: E
authors.lastname: Siktar
authors.forename: E
authors.initials: E
authors.lastname: Canakci
authors.forename: F
authors.initials: F
authors.lastname: Akcay
authors.forename: S
authors.initials: S
authors.lastname: Dane
authors.forename: M
authors.initials: M
authors.lastname: Gul
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D010805:Physical Conditioning, Animal / Q000502:physiology*; D010807:Physical Endurance / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012420:Running / Q000502:physiology; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005982:Glutathione Transferase