Sensitive liposomes encoded with oligonucleotide amphiphiles: a biocompatible switch.
DNA-tagged liposomes made of DOPC specifically bind to a fluorescently labelled complementary ss-DNA with virtually no influence from the lipid bilayer despite the absence of a linker; depending on an external stimulus, either physical (temperature) or chemical (competitive complementary ON sequences), the liposomes switch between an on and off fluorescent state depending on the location of the probe either at the surface or in the bulk.
Gissot
Arnaud
A
Université de Bordeaux, 33076 Bordeaux Cedex, France.
Di Primo
Carmelo
C
Bestel
Isabelle
I
Giannone
Gregory
G
Chapuis
Hubert
H
Barthélémy
Philippe
P
D001672:Biocompatible Materials / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000737:chemistry* / Q000378:metabolism; D010713:Phosphatidylcholines / Q000737:chemistry; D012680:Sensitivity and Specificity; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry*; D013696:Temperature; D013997:Time Factors
D001672:Biocompatible Materials; D008051:Lipid Bilayers; D008081:Liposomes; D009841:Oligonucleotides; D010713:Phosphatidylcholines; D013501:Surface-Active Agents; C017251:1,2-oleoylphosphatidylcholine