Synthesis and in-vitro activity of new 1beta-methylcarbapenem derivatives as antibacterial agents.
The synthesis of a new series of 1beta-methylcarbapenems having pyrrolidine and piperidine moieties is described. Their in-vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. A particular compound III b having an oxime-pyrrolidine moiety showed the most potent antibacterial activity.
Jung
Myung-Ho
MH
Biomaterials Research Center, Korea Institute of Science and Technology, Seoul, Korea.
Hong
Joon Hee
JH
Cho
Jung-Hyuck
JH
Oh
Chang-Hyun
CH
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D015780:Carbapenems / Q000138:chemical synthesis* / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010880:Piperidines; D011759:Pyrrolidines; D013329:Structure-Activity Relationship
C476323:1 beta-methylcarbapenem; D000900:Anti-Bacterial Agents; D015780:Carbapenems; D010880:Piperidines; D011759:Pyrrolidines; C032727:piperidine