title: Genetic dissection of testis weight in a mouse strain having an extremely large testis: major testis weight determinants are autosomal rather than Y-linked on the basis of comprehensive analyses in Y-chromosome consomic strains.
abstract: I investigated the potential contribution of Y-linked genes by analyzing 16 Y-consomic strains that had been established on a DH-strain background. The results provided evidence that only the Y chromosome from the C3H/HeJ strain was different from most other inbred strains. The CBA strain has the lightest testis and the DDD strain has the heaviest testis among mouse strains; however, Y-consomic analysis revealed that there were no significant differences in testis weight among DH, DH-Chr Y(DDD), and DH-Chr Y(CBA) strains, suggesting that Y(DDD) and Y(CBA) themselves do not influence testis weight. QTL analysis in DDD x DH F(2) mice identified significant testis weight QTLs on chromosomes 9, 14, and 17, and the DDD allele at all these loci was associated with an increase in testis weight. Contribution of Y chromosome itself to testis weight was thus rather modest, and therefore, major testis weight determinants are autosomal. However, it was uncertain whether there would be any effects by interactions between Y chromosomal and autosomal genes.
authors.affiliation: Division of Animal Sciences, National Institute of Agrobiological Sciences, Ibaraki, Japan. jsuto@affrc.go.jp
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Suto
mesh_terms: D000818:Animals; D050173:Genes, Y-Linked / Q000235:genetics; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000235:genetics*; D040641:Quantitative Trait Loci / Q000235:genetics; D013737:Testis / Q000033:anatomy & histology*; D014998:Y Chromosome / Q000235:genetics*