title: Pregnancy outcome after magnetic resonance-guided focused ultrasound surgery (MRgFUS) for conservative treatment of uterine fibroids.
abstract: OBJECTIVE
  To report all pregnancies to date after magnetic resonance-guided focused ultrasound surgery (MRgFUS) for the conservative treatment of clinically significant uterine fibroids.
  
  
  METHODS
  Prospective registry of all known pregnancies occurring after MRgFUS maintained by the device manufacturer and reported to the Food and Drug Administration.
  
  
  METHODS
  World experience of pregnancies after treatment with reports from 13 sites in seven countries.
  
  
  METHODS
  Fifty-one reproductive-age women with uterine leiomyomas.
  
  
  METHODS
  Women underwent MRgFUS treatment for symptomatic uterine leiomyomas before this report.
  
  
  METHODS
  Pregnancy outcomes and complications.
  
  
  RESULTS
  Fifty-four pregnancies in 51 women have occurred after MRgFUS treatment of uterine leiomyomas. The mean time to conception was 8 months after treatment. Live births occurred in 41% of pregnancies, with a 28% spontaneous abortion rate, an 11% rate of elective pregnancy termination, and 11 (20%) ongoing pregnancies beyond 20 gestational weeks. The mean birth weight was 3.3 kg, and the vaginal delivery rate was 64%.
  
  
  CONCLUSIONS
  Preliminary pregnancy experience after MRgFUS is encouraging, with a high rate of delivered and ongoing pregnancies.
authors.affiliation: Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: Jaron
authors.initials: J
authors.lastname: Rabinovici
authors.forename: Matthias
authors.initials: M
authors.lastname: David
authors.forename: Hidenobu
authors.initials: H
authors.lastname: Fukunishi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Morita
authors.forename: Bobbie S
authors.initials: BS
authors.lastname: Gostout
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Stewart
mesh_terms: D000028:Abortion, Induced; D000022:Abortion, Spontaneous; D000328:Adult; D001724:Birth Weight; D005060:Europe; D005260:Female; D005298:Fertility; D005865:Gestational Age; D013509:Gynecologic Surgical Procedures; D006801:Humans; D007231:Infant, Newborn; D007557:Israel; D007564:Japan; D007889:Leiomyoma / Q000503:physiopathology / Q000601:surgery*; D018231:Leiomyomatosis / Q000503:physiopathology / Q000601:surgery*; D050498:Live Birth; D053783:Magnetic Resonance Imaging, Interventional; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures; D011247:Pregnancy; D011256:Pregnancy Outcome; D017697:Premenopause; D011446:Prospective Studies; D012042:Registries; D013997:Time Factors; D016896:Treatment Outcome; D014481:United States; D014594:Uterine Neoplasms / Q000503:physiopathology / Q000601:surgery*