Decoding and engineering tetracycline biosynthesis.
Tetracyclines have been important agents in combating infectious disease since their discovery in the mid-20th century. Following widespread use, tetracycline resistance mechanisms emerged and continue to create a need for new derivatives that are active against resistant bacterial strains. Semisynthesis has led to second and third generation tetracycline derivatives with enhanced antibiotic activity and pharmacological properties. Recent advancement in understanding of the tetracycline biosynthetic pathway may open the door to broaden the range of tetracycline derivatives and afford analogs that are difficult to access by synthetic chemistry.
Pickens
Lauren B
LB
Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, 90095, USA.
Tang
Yi
Y
D008954:Models, Biological; D015202:Protein Engineering / Q000379:methods*; D011994:Recombinant Proteins / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D013302:Streptomyces / Q000502:physiology*; D013752:Tetracycline / Q000096:biosynthesis*
D011994:Recombinant Proteins; D013752:Tetracycline