Sexual activity and prostate cancer risk in men diagnosed at a younger age.
OBJECTIVE
To examine, in a case-control study, the association between the frequency of sexual activity (intercourse, masturbation, overall) and prostate cancer risk in younger men diagnosed at < or = 60 years old.


METHODS
In all, 431 prostate cancer cases and 409 controls participated and provided information on their sexual activity. In particular, the frequencies of intercourse and masturbation during the participants' different age decades (20s, 30s, 40s, 50s) were collected.


RESULTS
Whereas frequent overall sexual activity in younger life (20s) increased the disease risk, it appeared to be protective against the disease when older (50s). Alone, frequent masturbation activity was a marker for increased risk in the 20s and 30s but appeared to be associated with a decreased risk in the 50s, while intercourse activity alone was not associated with the disease.


CONCLUSIONS
These findings could imply different mechanisms by which sexual activity is involved in the aetiology of prostate cancer at different ages. Alternatively, there is a possibility of reverse causation in explaining part of the protective effect seen for men in their 50s.
Dimitropoulou
Polyxeni
P
University of Nottingham Medical School, Queens Medical Centre, Nottingham, UK. pd317@medschl.cam.ac.uk
Lophatananon
Artitaya
A
Easton
Douglas
D
Pocock
Richard
R
Dearnaley
David P
DP
Guy
Michelle
M
Edwards
Steven
S
O'Brien
Lynne
L
Hall
Amanda
A
Wilkinson
Rosemary
R
Eeles
Rosalind
R
Muir
Kenneth R
KR
D000328:Adult; D000367:Age Factors; D016022:Case-Control Studies; D003075:Coitus; D006801:Humans; D008297:Male; D008418:Masturbation / Q000150:complications*; D008875:Middle Aged; D015999:Multivariate Analysis; D011471:Prostatic Neoplasms / Q000209:etiology*; D012307:Risk Factors; D055815:Young Adult