[Epidemiology and Pathophysiology of the acute respiratory distress syndrome (ARDS)].
Despite the implementation of a multimodal concept of treatment, the acute respiratory distress syndrome (ARDS) is still afflicted with high mortality rates. A reasonable application and combination of possible treatment strategies, such as prone position, positive end-expiratory pressure (PEEP), restrictive volume therapy or nitric oxide (NO), requires pathophysiological and epidemiological knowledge. In the following article we describe basic pathophysiological parameters in development, progression and therapy of ARDS. Furthermore, we try to elucidate possible reasons for considerable limitations of multicentric studies in this field.
Deja
Maria
M
Klinik für Anästhesiologie mit Schwerpunkt operative Intensivmedizin, Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin. maria.deja@charite.de
Lojewski
Christian
C
Hommel
Matthias
M
Menk
Mario
M
Weimann
Jörg
J
D018450:Disease Progression; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D009569:Nitric Oxide / Q000627:therapeutic use; D010349:Patient Compliance; D011175:Positive-Pressure Respiration; D012128:Respiratory Distress Syndrome / Q000453:epidemiology* / Q000401:mortality / Q000503:physiopathology* / Q000628:therapy; D012138:Respiratory Therapy; D015996:Survival Rate; D014665:Vasodilator Agents / Q000627:therapeutic use
D014665:Vasodilator Agents; D009569:Nitric Oxide