title: Dissemination of OXA-23-producing and carbapenem-resistant Acinetobacter baumannii in a University Hospital in Tunisia.
abstract: Ninety-nine carbapenem-resistant Acinetobacter baumannii isolates were obtained from patients hospitalized between October 2005 and January 2007 at the University Hospital Sahloul, Sousse, Tunisia. Thirteen of those isolates produced the carbapenem-hydrolyzing oxacillinase OXA-23. All the OXA-23-positive isolates were clonally related, and the bla(OXA-23) gene was found to be chromosomally located and associated with an upstream-located insertion sequence ISAba1. This study further highlights the worldwide emergence of OXA-23-producing A. baumannii isolates.
authors.affiliation: Service de Bactériologie-Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine et Université Paris Paris-Sud, Bicêtre, France.
authors.forename: Wejdene
authors.initials: W
authors.lastname: Mansour
authors.forename: Laurent
authors.initials: L
authors.lastname: Poirel
authors.forename: Dalia
authors.initials: D
authors.lastname: Bettaieb
authors.forename: Olfa
authors.initials: O
authors.lastname: Bouallegue
authors.forename: Noureddine
authors.initials: N
authors.lastname: Boujaafar
authors.forename: Patrice
authors.initials: P
authors.lastname: Nordmann
mesh_terms: D000151:Acinetobacter Infections / Q000453:epidemiology* / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification; D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015780:Carbapenems / Q000494:pharmacology*; D004251:DNA Transposable Elements / Q000235:genetics; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D006785:Hospitals, University; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D014416:Tunisia / Q000453:epidemiology; D018440:beta-Lactam Resistance / Q000235:genetics*; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D004251:DNA Transposable Elements; C466679:beta-lactamase OXA-23; D001618:beta-Lactamases