Complement factor H variant Y402H is not a risk factor for preeclampsia in the Finnish population.
OBJECTIVE
Variations in complement factor H, which down-regulates the activity of the alternative complement pathway, have been associated with different vascular disorders. Here we examine whether factor H variation is involved in the etiology of preeclampsia.


METHODS
We studied 110 women with preeclampsia and 99 controls for complement factor H variations by sequencing.


RESULTS
No significant differences in the genotype or allele frequencies of the Y402H variant were detected between the two groups. No sequence variations were detected in the short consensus repeat domain 20 of the gene.


CONCLUSIONS
Neither the Y402H variant, nor mutations in the short consensus repeat domain 20 of the gene is associated with preeclampsia. For examination of possible links to other polymorphisms or detection of small genotypic effects, studies in larger sample sets are warranted.
Kaare
M
M
Folkhälsan Institute of Genetics, University of Helsinki, Finland. milja.kaare@helsinki.fi
Seitsonen
S
S
Jarvela
I
I
Meri
S
S
Laivuori
H
H
D000328:Adult; D000483:Alleles; D017242:Complement Factor H / Q000235:genetics; D005260:Female; D005387:Finland; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D012189:Retrospective Studies; D044465:White People
C493495:CFH protein, human; D017242:Complement Factor H