Identification of the novel HLA-A*9250 allele by sequence-based typing in a Caucasian bone marrow donor from Italy.
HLA-A*9250 allele was identified by SBT in a Caucasian bone marrow donor. It differs from the closest A*020101 by only one nucleotide (A-->G) at position 124 in exon 2 (Arg to Gly at codon 18); this is an uncommon variation at a highly conserved nucleotide position, located on the loop between S1-S2 beta-sheets in alpha1 domain.
Canossi
A
A
CNR Institute Organ Transplants and Immunocitology, L'Aquila, Italy. angelica.canossi@cnr.it
Del Beato
T
T
Liberatore
G
G
Papola
F
F
Adorno
D
D
D000483:Alleles; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution / Q000235:genetics*; D001483:Base Sequence; D001853:Bone Marrow; D005091:Exons / Q000235:genetics*; D015234:HLA-A Antigens / Q000235:genetics*; D015789:HLA-A2 Antigen; D006801:Humans; D007558:Italy; D019520:Living Donors; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D044465:White People / Q000235:genetics
D015234:HLA-A Antigens; C538919:HLA-A*02:150 antigen; D015789:HLA-A2 Antigen