title: Condensed 1,4-dihydropyridines with various esters and their calcium channel antagonist activities.
abstract: New alkyl 2,6,6-(2,7,7)-trimethyl-4-(2-fluoro-3-chloro-5-trifluoromethylphenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylates and 9-(3-chloro-2-fluoro-5-trifluoromethylphenyl)-6,6(7,7)-dimethyl-6,7-dihydrofuro[3,4-b]quinoline-1,8-diones have been synthesised and their calcium antagonistic activities on isolated rabbit sigmoid colon have been investigated and compared with Nifedipine. The investigation examined the influence of ester groups in the 3-position of the HHQ ring and the 2-methoxyethyl analogs were found to be the most active derivatives.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Turkey.
authors.forename: Bahadir
authors.initials: B
authors.lastname: Bülbül
authors.forename: Gökçe Sevim
authors.initials: GS
authors.lastname: Oztürk
authors.forename: Mert
authors.initials: M
authors.lastname: Vural
authors.forename: Rahime
authors.initials: R
authors.lastname: Simşek
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Sarioğlu
authors.forename: Anthony
authors.initials: A
authors.lastname: Linden
authors.forename: Mert
authors.initials: M
authors.lastname: Ulgen
authors.forename: Cihat
authors.initials: C
authors.lastname: Safak
mesh_terms: D000818:Animals; D002121:Calcium Channel Blockers / Q000737:chemistry*; D003106:Colon / Q000187:drug effects; D004095:Dihydropyridines / Q000737:chemistry* / Q000494:pharmacology; D004952:Esters; D066298:In Vitro Techniques; D011817:Rabbits; D013329:Structure-Activity Relationship
chemical_list: D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D004952:Esters