Adiponectin stimulates IL-8 production by rheumatoid synovial fibroblasts.
The adipokines are linked not only to metabolic regulation, but also to immune responses. Adiponectin, but not leptin or resistin induced interleukin-8 production from rheumatoid synovial fibroblasts (RSF). The culture supernatant of RSF treated with adiponectin induced chemotaxis, although adiponectin itself had no such effect. Addition of antibody against adiponectin, and inhibition of adiponectin receptor gene decreased adiponectin-induced IL-8 production. Nuclear translocation of nuclear factor-kappa B was increased by adiponectin. The induction of interleukin-8 was inhibited by mitogen-activated protein kinase inhibitors. These findings suggest that adiponectin contributes to the pathogenesis of rheumatoid arthritis.
Kitahara
Kanako
K
Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, 6-11-1 Omori-Nishi, Ota-ku, Tokyo 143-8541, Japan.
Kusunoki
Natsuko
N
Kakiuchi
Terutaka
T
Suguro
Toru
T
Kawai
Shinichi
S
D052242:Adiponectin / Q000037:antagonists & inhibitors / Q000276:immunology* / Q000494:pharmacology; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D002478:Cells, Cultured; D002633:Chemotaxis / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects / Q000276:immunology; D006801:Humans; D016209:Interleukin-8 / Q000096:biosynthesis*; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D054419:Receptors, Adiponectin / Q000096:biosynthesis; D015398:Signal Transduction; D013582:Synovial Fluid / Q000187:drug effects / Q000276:immunology*
C475418:ADIPOR1 protein, human; C475420:ADIPOR2 protein, human; D052242:Adiponectin; D016209:Interleukin-8; D047428:Protein Kinase Inhibitors; D054419:Receptors, Adiponectin