title: Successful treatment of pediatric stroke with recombinant tissue plasminogen activator (rt-PA): a case report and review of the literature.
abstract: Pediatric stroke is a rare disorder with a paucity of evidence-based treatment options, and can result in significant morbidity and mortality. In contrast to adult acute ischemic stroke, where the use of recombinant tissue plasminogen activator (rt-PA) has been studied in several large, randomized clinical trials, no high-level evidence exists for the use of thrombolytics in children with stroke. We report a case of a 15-year-old girl who suffered an acute ischemic stroke and had a dramatic improvement in symptoms following the administration of intravenous rt-PA.
authors.affiliation: Department of Biostatistics and Epidemiology, University of Western Ontario, London, Ontario, Canada.
authors.forename: Shirra
authors.initials: S
authors.lastname: Cremer
authors.forename: Yaniv
authors.initials: Y
authors.lastname: Berliner
authors.forename: David
authors.initials: D
authors.lastname: Warren
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Jones
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D002545:Brain Ischemia / Q000150:complications; D015984:Causality; D004638:Emergency Treatment / Q000379:methods*; D055416:Evidence-Based Emergency Medicine; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D009017:Morbidity; D010372:Pediatrics / Q000379:methods*; D017410:Practice Guidelines as Topic; D016032:Randomized Controlled Trials as Topic; D035583:Rare Diseases; D020521:Stroke / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator