title: Traditional Chinese medicine plus transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma.
abstract: OBJECTIVE
  To compare the efficacy and safety of Traditional Chinese Medicine (TCM) plus transcatheter arterial chemoembolization (TACE) with that of TACE alone (therapy I versus therapy II, respectively) in treating unresectable hepatocellular carcinoma (UHCC) through a meta-analysis of all available randomized controlled trials.
  
  
  METHODS
  Literature retrieval was conducted using the Cochrane Library, MEDLINE, EMBASE, CBMdisk, and CNKI in any language. Meta-analysis was performed on the results of homogeneous studies. Analyses subdivided by TACE frequency (subgroup A, <3 times; subgroup B, > or =3 times) were also performed, but were not done for both therapy I and therapy II.
  
  
  RESULTS
  Based on our search criteria, we found 37 trials involving 2653 patients. Our results showed that therapy I, compared with therapy II, improved patient survival, quality of life, alleviation of symptoms, and tumor response, and was thus more therapeutically beneficial. Further analysis showed that subgroup A proved to be better for patients' survival and alleviation of symptoms, while the two subgroups were similar in improved tumor response. No serious adverse events were reported.
  
  
  CONCLUSIONS
  Therapy I benefited patients with UHCC. Subgroup A improved the survival of patients and the amelioration of symptoms more than subgroup B. As in some trials, there were flaws in the methodological quality, and the data therefore have a risk of bias and of being insufficient for determining the effects of therapy I and subgroup A. Hence, further large-scale trials are warranted.
authors.affiliation: Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Mao-Bin
authors.initials: MB
authors.lastname: Meng
authors.forename: Yao-Li
authors.initials: YL
authors.lastname: Cui
authors.forename: Yong-Song
authors.initials: YS
authors.lastname: Guan
authors.forename: Zhang
authors.initials: Z
authors.lastname: Ying
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Zheng
authors.forename: Cheng-Kai
authors.initials: CK
authors.lastname: Yuan
authors.forename: Rui-Ming
authors.initials: RM
authors.lastname: Zhang
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000628:therapy*; D016461:Chemoembolization, Therapeutic / Q000379:methods*; D003131:Combined Modality Therapy; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D019317:Evidence-Based Medicine; D006801:Humans; D008113:Liver Neoplasms / Q000628:therapy*; D008516:Medicine, Chinese Traditional; D016032:Randomized Controlled Trials as Topic; D012107:Research Design; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal