title: Genetic variations in FTSJ1 influence cognitive ability in young males in the Chinese Han population.
abstract: Human cognitive ability is a trait that is known to be significantly influenced by genetic factors. Previous linkage data provide evidence suggesting that gene FtsJ homolog 1 (Escherichia coli) is associated with mental retardation. The gene may have a relation to individual differences in cognitive ability because it is most critical for brain development. In the present research, three tag single-nucleotide polymorphism (SNPs) (rs2268954, rs2070991, and rs5905692) in FtsJ homolog 1 (E. coli) are selected and genotyped by the PCR-SSCP method. An analysis of variance is performed to determine the relationship between the SNPs and cognitive ability of the Chinese Han population of youth in Qinba mountain. There are significant correlations between the variance in FtsJ homolog 1 (E. coli) and general cognitive ability, verbal comprehension, and preceptual organization. These findings suggest that genetic variations in FtsJ homolog 1 (E. coli) possibly influence human cognitive ability.
authors.affiliation: School of Life Science, Institute of Population and Health, Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, China
authors.forename: Pingyuan
authors.initials: P
authors.lastname: Gong
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Ling
authors.initials: L
authors.lastname: Dai
authors.forename: Kejin
authors.initials: K
authors.lastname: Zhang
authors.forename: Zijian
authors.initials: Z
authors.lastname: Zheng
authors.forename: Xiaocai
authors.initials: X
authors.lastname: Gao
authors.forename: Fuchang
authors.initials: F
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D044466:Asian People / Q000235:genetics; D002648:Child; D003071:Cognition / Q000502:physiology*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007361:Intelligence Tests; D008297:Male; D038901:X-Linked Intellectual Disability / Q000235:genetics; D008780:Methyltransferases / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D018807:Polymorphism, Single-Stranded Conformational; D011594:Psychometrics; D012737:Sex Factors
chemical_list: D009687:Nuclear Proteins; C490101:FTSJ1 protein, human; D008780:Methyltransferases