Requirement of IL-17RA in Con A induced hepatitis and negative regulation of IL-17 production in mouse T cells.
Th17 cells, a subset of T cells involved in autoimmunity and host defense against extracellular Gram-negative infection, express both IL-17A and IL-17F. Both IL-17A and IL-17F can signal via the IL-17RA; however, IL-17F does so at a 1- to 2-log higher concentration than IL-17A. In this study, we show that the IL-17F homodimer via IL-17RA is a negative regulator of IL-17 production in T cells and suggest a mechanism whereby IL-17RA on T cells serves as an autocrine/paracrine regulator of IL-17 synthesis in T cells.
Nagata
Takako
T
Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15213, USA.
McKinley
Laura
L
Peschon
Jacques J
JJ
Alcorn
John F
JF
Aujla
Shean J
SJ
Kolls
Jay K
JK
D000818:Animals; D019898:Autocrine Communication / Q000235:genetics / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D056486:Chemical and Drug Induced Liver Injury / Q000235:genetics / Q000276:immunology*; D003208:Concanavalin A / Q000633:toxicity*; D016905:Gram-Negative Bacterial Infections / Q000235:genetics / Q000276:immunology; D020381:Interleukin-17 / Q000235:genetics / Q000276:immunology*; D051379:Mice; D018345:Mice, Knockout; D008934:Mitogens / Q000633:toxicity*; D019899:Paracrine Communication / Q000235:genetics / Q000276:immunology; D053722:Receptors, Interleukin-17 / Q000235:genetics / Q000276:immunology*; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology
C098680:Il17a protein, mouse; C515932:Il17f protein, mouse; C491673:Il17ra protein, mouse; D020381:Interleukin-17; D008934:Mitogens; D053722:Receptors, Interleukin-17; D003208:Concanavalin A