title: Liver transplantation with grafts from septuagenarians.
abstract: BACKGROUND
  The purpose of this study was to evaluate our experience with orthotopic liver transplantation (OLT) using grafts from septuagenarians.
  
  
  METHODS
  Seventeen adult patients underwent transplantation with grafts from donors 70 years of age or older during an 8-year period.
  
  
  RESULTS
  The median donor age was 73 years (range, 70-83). Eleven (64.7%) donors had experienced at least 1 hypotensive period and received vasoactive drugs. Median cold and warm ischemia times were 7.25 hours and 35 minutes, respectively. Two recipients underwent retransplantation because of dysfunction or primary nonfunction. Morbidity rate was 47% and hospital mortality rate was 23.5%. After a median follow-up of 34.5 months (range, 3-84 months), 5 additional patients died. Median patient survival was 17 months (range, 0-84 months). One-, 3-, 5-, and 7-year cumulative survival rates were 69.7%, 57.5%, 46.2%, and 23.3%, respectively. Only graft dysfunction (P = .042) was observed to be an independent predictor of survival upon multivariate analysis.
  
  
  CONCLUSIONS
  Although grafts from septuagenarians allow for expansion of the donor pool, long-term recipient survival is inferior to that encountered with younger donors.
authors.affiliation: Department of General, Visceral, and Transplantation Surgery, University Hospital Essen, Essen, Germany; Organ Transplant Unit, Hippocration University Hospital, Thessaloniki, Greece.
authors.forename: I
authors.initials: I
authors.lastname: Fouzas
authors.forename: G
authors.initials: G
authors.lastname: Sgourakis
authors.forename: K M
authors.initials: KM
authors.lastname: Nowak
authors.forename: H
authors.initials: H
authors.lastname: Lang
authors.forename: V R
authors.initials: VR
authors.lastname: Cicinnati
authors.forename: E P
authors.initials: EP
authors.lastname: Molmenti
authors.forename: F H
authors.initials: FH
authors.lastname: Saner
authors.forename: S
authors.initials: S
authors.lastname: Nadalin
authors.forename: V
authors.initials: V
authors.lastname: Papanikolaou
authors.forename: C E
authors.initials: CE
authors.lastname: Broelsch
authors.forename: A
authors.initials: A
authors.lastname: Paul
authors.forename: G C
authors.initials: GC
authors.lastname: Sotiropoulos
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002423:Cause of Death; D005260:Female; D017052:Hospital Mortality / Q000639:trends; D006801:Humans; D017093:Liver Failure / Q000209:etiology / Q000601:surgery; D016031:Liver Transplantation / Q000401:mortality / Q000706:statistics & numerical data*; D008297:Male; D012086:Reoperation / Q000706:statistics & numerical data; D012189:Retrospective Studies; D015996:Survival Rate; D014019:Tissue Donors / Q000600:supply & distribution*