title: Oxidative stress and inflammatory markers in normal pregnancy and preeclampsia.
abstract: OBJECTIVE
  Although previous investigators have demonstrated the presence of oxidative stress and inflammation in preeclampsia, none directly correlate both to preeclampsia.
  
  
  METHODS
  We determined in 35 preeclamptic and 35 normotensive pregnant women plasma levels of thiobarbituric acid reactive species, protein carbonyl, tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6 and IL-10.
  
  
  RESULTS
  Plasma thiobarbituric acid reactive species and protein carbonyls were higher in preeclamptic patients. TNF-alpha and IL-6 (but not IL-1beta or IL-10) were higher in preeclamptic patients. We found significant correlation between plasma IL-6 and carbonyls, and these correlated to blood pressure.
  
  
  CONCLUSIONS
  We demonstrated that some oxidative and inflammatory mediators were altered in preeclampsia, and some correlated to blood pressure.
authors.affiliation: Experimental Physiopathology Laboratory, University of the Extreme South Catarinense, SC, Brazil.
authors.forename: Fabiana
authors.initials: F
authors.lastname: Bernardi
authors.forename: Francieli
authors.initials: F
authors.lastname: Guolo
authors.forename: Thaize
authors.initials: T
authors.lastname: Bortolin
authors.forename: Fabricia
authors.initials: F
authors.lastname: Petronilho
authors.forename: Felipe
authors.initials: F
authors.lastname: Dal-Pizzol
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D018384:Oxidative Stress; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy / Q000097:blood*; D055815:Young Adult
chemical_list: D018836:Inflammation Mediators