title: Palladium-catalyzed asymmetric decarboxylative lactamization of gamma-methylidene-delta-valerolactones with isocyanates: conversion of racemic lactones to enantioenriched lactams.
abstract: A palladium-catalyzed asymmetric decarboxylative reaction of racemic gamma-methylidene-delta-valerolactones with aryl isocyanates has been developed to give enantioenriched 3,3-disubstituted 2-piperidones. High enantioselectivity has been achieved by tuning the ester group on substrate and the substituents of phosphoramidite ligand.
authors.affiliation: Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan. shintani@kuchem.kyoto-u.ac.jp
authors.forename: Ryo
authors.initials: R
authors.lastname: Shintani
authors.forename: Soyoung
authors.initials: S
authors.lastname: Park
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Shirozu
authors.forename: Masataka
authors.initials: M
authors.lastname: Murakami
authors.forename: Tamio
authors.initials: T
authors.lastname: Hayashi