title: Evaluation of antibacterial activity of synthetic aliphatic and aromatic monoacylglycerols.
abstract: The antibacterial activity of synthetic aliphatic and aromatic monoacylglycerols (MAGs) was studied against two human pathogens: Staphylococcus aureus and Escherichia coli. The active compounds inhibited selectively S. aureus. The most active compounds amongst them were those with medium size aliphatic chain and aromatic MAGs with electron withdrawing substituents at the aryl ring. The introduction of one or two-carbon spacer between the aryl ring and the carboxylic function did not influence antibacterial effectiveness.
authors.affiliation: Institute of Organic Chemistry, Centre of Phytochemistry Bulgarian Academy of Sciences, Sofia, Bulgaria. danibat@orgchm.bas.bg
authors.forename: Daniela
authors.initials: D
authors.lastname: Batovska
authors.forename: Iva
authors.initials: I
authors.lastname: Todorova
authors.forename: Stoyan
authors.initials: S
authors.lastname: Parushev
authors.forename: Iva
authors.initials: I
authors.lastname: Tsvetkova
authors.forename: Hristo
authors.initials: H
authors.lastname: Najdenski
authors.forename: Makoto
authors.initials: M
authors.lastname: Ubukata
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D050178:Monoglycerides / Q000138:chemical synthesis* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D050178:Monoglycerides