New insights into thiol-mediated regulation of adiponectin secretion.
Adiponectin is a protein secreted into the circulation exclusively by adipocytes. It acts as an anti-diabetic and anti-atherogenic adipokine. Its plasma level is lowered in conditions of obesity, diabetes, and atherosclerosis. Within adipocytes, it is retained in the lumen of the endoplasmic reticulum by binding to the thiol protein ERp44 and released by another thiol protein, Ero1-Lalpha. Nuclear receptor PPARgamma ligand agonists appear to regulate its retention-release mechanism.
Wolf
George
G
Department of Nutritional Sciences and Toxicology at the University of California, Berkeley, California 94720, USA. nutritionreviews@ilsi.org
D016475:3T3 Cells; D017667:Adipocytes / Q000166:cytology / Q000378:metabolism*; D052242:Adiponectin / Q000378:metabolism*; D000818:Animals; D006023:Glycoproteins; D006801:Humans; D008565:Membrane Proteins; D051379:Mice; D018832:Molecular Chaperones; D010088:Oxidoreductases; D047495:PPAR gamma / Q000819:agonists* / Q000378:metabolism*; D011485:Protein Binding; D011499:Protein Processing, Post-Translational / Q000187:drug effects*; D015398:Signal Transduction
D052242:Adiponectin; C520556:ERp44 protein, mouse; D006023:Glycoproteins; D008565:Membrane Proteins; D018832:Molecular Chaperones; D047495:PPAR gamma; C491864:Ero1l protein, mouse; D010088:Oxidoreductases