title: Transplanted corneal graft with metastatic cholangiocarcinoma to the donor eye.
abstract: OBJECTIVE
  To report a case of corneal transplantation from a donor died of cholangiocarcinoma with metastasis to the eye.
  
  
  METHODS
  A patient with limbal dermoid received corneal transplant from a donor died of cholangiocarcinoma. Pathologic examination of the remaining donor limbal tissue revealed metastasis of tumor to the limbal vessels. Prompt exchange of the graft was performed. Before the second corneal transplantation, the surrounding tissue of the recipient bed was excised and sent for histopathologic examination.
  
  
  RESULTS
  No tumor transmission was noted surrounding the recipient bed. The second graft remained clear and the patient remained cancer free after regular examination for over a year.
  
  
  CONCLUSIONS
  This is the first case to report that cholangiocarcinoma can metastasize to the corneal limbus. To avoid transmission of malignancies from the donor to the recipient, we suggest that donor tissue with history of malignancy should not be used for limbal allografting, and that frozen-section examination of donor limbal tissue is recommended before the transplantation.
authors.affiliation: Department of Ocular Surface Disorders, Shenzhen Ophthalmic Center Affiliated Ji'nan University, Shenzhen, China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Yao
authors.forename: Ming
authors.initials: M
authors.lastname: Lee
authors.forename: Fangwei
authors.initials: F
authors.lastname: Ying
authors.forename: Lina
authors.initials: L
authors.lastname: Huang
authors.forename: Wei
authors.initials: W
authors.lastname: Qi
authors.forename: Puning
authors.initials: P
authors.lastname: Zhao
authors.forename: Yu-Guang
authors.initials: YG
authors.lastname: He
mesh_terms: D000293:Adolescent; D001650:Bile Duct Neoplasms / Q000401:mortality / Q000473:pathology; D001653:Bile Ducts, Intrahepatic; D018281:Cholangiocarcinoma / Q000209:etiology* / Q000401:mortality / Q000473:pathology / Q000556:secondary; D003316:Corneal Diseases / Q000209:etiology* / Q000473:pathology; D016039:Corneal Transplantation / Q000009:adverse effects*; D005134:Eye Neoplasms / Q000209:etiology* / Q000473:pathology / Q000556:secondary; D005260:Female; D006801:Humans; D008875:Middle Aged; D012086:Reoperation; D014019:Tissue Donors