title: Flexible total synthesis of biphenomycin B.
abstract: A total synthesis of the biaryl antibiotic biphenomycin B is reported which makes use of three independent building blocks (key steps were a clean Suzuki-Miyaura coupling of a free acid iodide, a novel 4-hydroxyornithine synthesis, and a high-yielding macrolactamization); a practical deprotection protocol allowed isolation of the target compound with excellent recovery and purity.
authors.affiliation: Technische Universität Dortmund, Fakultät Chemie, Otto-Hahn-Str. 6, D-44227, Dortmund, Germany.
authors.forename: Herbert
authors.initials: H
authors.lastname: Waldmann
authors.forename: Yu-Peng
authors.initials: YP
authors.lastname: He
authors.forename: Hao
authors.initials: H
authors.lastname: Tan
authors.forename: Lars
authors.initials: L
authors.lastname: Arve
authors.forename: Hans-Dieter
authors.initials: HD
authors.lastname: Arndt
mesh_terms: D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D010456:Peptides, Cyclic; C047537:biphenomycin B