title: A highly sensitive and selective OFF-ON fluorescent sensor for cadmium in aqueous solution and living cell.
abstract: A highly selective and sensitive OFF-ON fluorescent sensor 1, employing the PET mechanism, was designed and synthesized. It could be used to detect Cd(2+) ion in aqueous solution and to image Cd(2+) ion in living cells. The fluorescence intensity significantly enhanced about 195-fold and the quantum yield increased almost 100-fold. Moreover the fluorescence intensity of 1 increased linearly with high sensitivity (0-1 microM) toward Cd(2+).
authors.affiliation: Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
authors.forename: Tanyu
authors.initials: T
authors.lastname: Cheng
authors.forename: Yufang
authors.initials: Y
authors.lastname: Xu
authors.forename: Shenyi
authors.initials: S
authors.lastname: Zhang
authors.forename: Weiping
authors.initials: W
authors.lastname: Zhu
authors.forename: Xuhong
authors.initials: X
authors.lastname: Qian
authors.forename: Liping
authors.initials: L
authors.lastname: Duan
mesh_terms: D002104:Cadmium / Q000737:chemistry*; D002470:Cell Survival; D005456:Fluorescent Dyes / Q000032:analysis* / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D012680:Sensitivity and Specificity; D012996:Solutions; D013050:Spectrometry, Fluorescence
chemical_list: D005456:Fluorescent Dyes; D012996:Solutions; D002104:Cadmium