BTB/POZ domain of speckle-type POZ protein (SPOP) confers proapoptotic function in HeLa cells.
The proapoptotic function of SPOP protein was investigated in HeLa cells. HeLa cells underwent apoptosis by the overexpression of SPOP. Studies using SPOP deletion mutants suggest that BTB/POZ domain of SPOP protein is important for the induction of apoptosis in transfected cells. This study first proposes the proapoptotic aspect of the BTB/POZ domain of SPOP protein based on the finding that cells expressing the C-terminal fragment of SPOP containing the BTB/POZ domain underwent apoptosis.
Byun
Boohyeong
B
Department of Oriental Medicine, Daegu Haany University, Daegu, South Korea. bhbyun@dhu.ac.kr
Tak
Heejae
H
Joe
Cheol O
CO
D017209:Apoptosis / Q000235:genetics / Q000502:physiology*; D001665:Binding Sites / Q000235:genetics / Q000502:physiology; D015153:Blotting, Western; D006367:HeLa Cells; D006801:Humans; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D014162:Transfection
D009687:Nuclear Proteins; D012097:Repressor Proteins; C509761:SPOP protein, human