Evaluation of anti-inflammatory and antioxidant activities of copper (II) Schiff mono-base and copper(II) Schiff base coordination compounds of dien with heterocyclic aldehydes and 2-amino-5-methyl-thiazole.
Highly reactive radicals are implicated in many pathological conditions. The quest for radical scavengers or antioxidants, spans the previous decades. A new series of complexes of the type [Cu (dien) (2a-2tzn) Y(2)] and [Cu (dienXXY(2)) (2a-5mt)] and of the type [Cu (dptaS) Cl(2)] and [Cu (dptaS) Br(2)] (dptaS = 1, 3-propanediamine) or Schiff mono-base of dipropylenetriamine with 2-thiophene-carboxaldehyde, has been tested for anti-inflammatory and antioxidant activity. The tested compounds inhibit the carrageenin-induced rat paw edema (52.0-82.6%) and present important scavenging activity. Compound 6 is the most potent (82.6%) in the in vivo experiment. Lipophilicity-as R(M) values - has been determined. The results support that in general, adducts of the type [Cu (dienXXY(2)) (2a-5mt)] exhibit increased activity compared to the starting material of type [Cu (dienXXY(2))]. An attempt to correlate the biological results with their structural characteristics and physicochemical parameters has been made.
Pontiki
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Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Hadjipavlou-Litina
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Chaviara
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D000447:Aldehydes / Q000737:chemistry*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000627:therapeutic use*; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D002351:Carrageenan / Q000494:pharmacology; D003300:Copper / Q000737:chemistry*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D006571:Heterocyclic Compounds / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D015394:Molecular Structure; D051381:Rats; D012545:Schiff Bases / Q000737:chemistry; D013844:Thiazoles / Q000737:chemistry*
C529877:2-amino-5-methylthiazole; D000447:Aldehydes; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D006571:Heterocyclic Compounds; D012545:Schiff Bases; D013844:Thiazoles; D003300:Copper; D002351:Carrageenan