Imiquimod in vulvar Paget's disease: a case report.
BACKGROUND
Vulvar Paget's disease is a relatively rare gynecologic neoplasm that is problematic because of its propensity to recur.


METHODS
An 80-year-old woman was found to have recurrent Paget's disease of the vulva. She was initially diagnosed 12 years previously and had had multiple resections for the disease. She was found to have histologically proven Paget's disease and underwent a course of topical immune modulator therapy with imiquimod. Biopsy proved histologic regression of the disease progress. The patient remained without recurrence 12 months after therapy.


CONCLUSIONS
In select patients imiquimod may be used to treat or facilitate treatment of vulvar Paget's disease.
Geisler
John P
JP
Indiana Women's Oncology, Division of Gynecologic Oncology, St. Vincent Hospitals, Indianapolis, IN 46260, USA. jgeisler@indianawomensoncology.com
Manahan
Kelly J
KJ
D000369:Aged, 80 and over; D000634:Aminoquinolines / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D000077271:Imiquimod; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D010145:Paget Disease, Extramammary / Q000188:drug therapy*; D012074:Remission Induction / Q000379:methods; D016896:Treatment Outcome; D014846:Vulvar Neoplasms / Q000188:drug therapy*
D000634:Aminoquinolines; D000077271:Imiquimod