[Effects of Xuefu Zhuyu Oral Liquid on hemorheology in patients with blood-stasis syndrome due to coronary disease and their relationship with human platelet antigen-3 polymorphism].
OBJECTIVE
To investigate the effects of Xuefu Zhuyu Oral Liquid, a compound traditional Chinese herbal medicine for resolving stagnation, on hemorheology in the patients with blood-stasis syndrome due to coronary disease and their relationship with human platelet antigen-3 (HPA-3) polymorphism of membrane glycoprotein IIb (GPIIb).


METHODS
Thirty-two patients with blood-stasis syndrome due to coronary disease were selected in this study. Blood-stasis syndrome scoring was performed and hemorheological parameters were measured in all subjects before and after Xuefu Zhuyu Qral Liquid treatment. The genotypes of GPIIb HPA-3 were determined by TaqMan probe technology.


RESULTS
The hemorheology was improved in the patients with blood-stasis syndrome due to coronary heart disease after the treatment. There were significant differences in the whole blood viscosity, deformation index of red blood cells and scores of blood-stasis syndrome between the patients carrying AC plus CC and the patients carrying AA after the treatment (P<0.05).


CONCLUSIONS
Xuefu Zhuyu Oral Liquid can improve clinical symptoms and hemorheology in the patients with blood-stasis syndrome due to coronary heart disease, which is related to GPIIb HPA-3 polymorphism.
Xue
Mei
M
Laboratory of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Chen
Ke-ji
KJ
Ma
Xiao-juan
XJ
Liu
Jian-gang
JG
Jiang
Yue-rong
YR
Miao
Yu
Y
Yin
Hui-jun
HJ
D000368:Aged; D016824:Antigens, Human Platelet / Q000235:genetics*; D003327:Coronary Disease / Q000097:blood* / Q000188:drug therapy / Q000235:genetics*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005838:Genotype; D018056:Hemorheology / Q000187:drug effects; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D040201:Platelet Membrane Glycoprotein IIb / Q000235:genetics*; D011110:Polymorphism, Genetic
D016824:Antigens, Human Platelet; D004365:Drugs, Chinese Herbal; D040201:Platelet Membrane Glycoprotein IIb; C513826:Xue-Fu-Zhu-Yu decoction