[A case of interstitial pneumonia after S-1 administration for gastric cancer].
An 80-year-old man with no history of thoracic radiotherapy nor interstitial pneumonia was administered S-1 for gastric cancer in June 2007. Twenty-two days after starting S-1, he had dyspnea, and X-rays showed reticular shadows in both lung fields, yielding a diagnosis of interstitial pneumonia. Drug lymphocyte stimulating test (DLST) was positive against S-1. The total dose of S-1 was 2,200 mg to the symptom onset. We immediately started steroid pulse therapy after emergency hospitalization, and it revealed improved condition and he was able to leave the hospital. S-1 administration is becoming frequent because RCTs supported the efficacy of S-1 for gastric cancer. Interstitial pneumonia as a side effect of S-1 is not frequent, but it is necessary to pay attention to dyspnea throughout the duration of administration.
Yamamoto
Naoto
N
Gastroenterological Center, Yokohama City University Medical Center.
Ohshima
Takashi
T
Sato
Tsutomu
T
Makino
Hirochika
H
Kanazawa
Amane
A
Yamada
Takanobu
T
Murakami
Hitoshi
H
Yukawa
Norio
N
Nagano
Yasuhiko
Y
Fujii
Shoichi
S
Kunisaki
Chikara
C
Tsukahara
Toshinori
T
Rino
Yasushi
Y
Masuda
Munetaka
M
Imada
Toshio
T
D000369:Aged, 80 and over; D004338:Drug Combinations; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000150:complications* / Q000000981:diagnostic imaging*; D008297:Male; D010094:Oxonic Acid / Q000008:administration & dosage* / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D005641:Tegafur / Q000008:administration & dosage* / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid