title: [A case of gastric cancer accompanied by disseminated carcinomatosis of bone marrow with DIC recovered by sequential therapy consisting of MTX and 5-FU].
abstract: A 78-year-old male was admitted to our hospital complaining of anorexia. Endoscopy revealed gastric cancer with pyloric stenosis and MRI showed multiple metastasis of thoracic vertebral body. Blood examinations showed DIC and CEA was 118.3 ng/mL. Sternum bone marrow biopsy revealed poorly-differentiated adenocarcinoma. Chemotherapy with sequential therapy consisting of MTX and 5-FU (MTX 150 mg/body, 5-FU 1,000 mg/body) was performed in addition to anti-DIC therapy. After 3 courses, DIC was resolved. Then, we changed the chemotherapy regimen to S-1/ paclitaxel (S-1 60 mg/body, PTX 60 mg/body). After 2 courses, the primary tumor was remarkably reduced and CEA decreased to within normal limits. After discharge, the patient has been undergoing chemotherapy on an outpatient basis.
authors.affiliation: Dept. of Surgery, Okayama Saiseikai General Hospital.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Yasuda
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Kimura
authors.forename: Masayuki
authors.initials: M
authors.lastname: Seita
authors.forename: Takaomi
authors.initials: T
authors.lastname: Takahata
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Akazai
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D019046:Bone Marrow Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D002272:Carcinoembryonic Antigen / Q000097:blood; D002277:Carcinoma / Q000097:blood / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D004211:Disseminated Intravascular Coagulation / Q000150:complications*; D005472:Fluorouracil / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013274:Stomach Neoplasms / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000473:pathology*
chemical_list: D002272:Carcinoembryonic Antigen; C099908:methotrexate-N,N'-bis(decylamide); D005472:Fluorouracil; D008727:Methotrexate