Treatment of vascular calcification.
A variety of potential therapies for vascular calcification, based either on the underlying biology or physical chemistry or solely on empiric observations in patients, may be effective but lack rigorous testing. Pasch et al. provide convincing evidence that sodium thiosulfate prevents medial vascular calcification in uremic rats. Although this provides some scientific basis for the clinical use of thiosulfate, uncertainty about mechanism of action and safety still remains.
O'Neill
W Charles
WC
Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA. woneill@emory.edu
D000818:Animals; D002114:Calcinosis / Q000188:drug therapy*; D006801:Humans; D007674:Kidney Diseases / Q000150:complications*; D012079:Renal Circulation / Q000187:drug effects*; D013885:Thiosulfates / Q000494:pharmacology; D014652:Vascular Diseases / Q000188:drug therapy
D013885:Thiosulfates; C017717:sodium thiosulfate