A long-term user of cosmetic cream containing estrogen developed breast cancer and endometrial hyperplasia.
A 93-year-old woman was referred to our clinic for abnormal genital bleeding. It was found that she had endometrial hyperplasia and breast cancer. Her uterus was as large as that of a normal adult menstruating woman. She indicated that she had been applying cosmetic cream containing a low concentration of ethynylestradiol to her face and body three times a day for 75 years. It is possible that this long-term use of the ethynylestradiol-containing cream is related to the development of breast cancer and endometrial hyperplasia.
Komori
Shinji
S
Department of Obstetrics and Gynecology, Hyogo College of Medicine, Hyogo, Japan. komor615@hyo-med.ac.jp
Ito
Yoshihiro
Y
Nakamura
Yuri
Y
Aoki
Michi
M
Takashi
Takenobu
T
Kinuta
Takatoshi
T
Tanaka
Hiroyuki
H
Koyama
Koji
K
D000279:Administration, Cutaneous; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000209:etiology*; D003358:Cosmetics / Q000009:adverse effects*; D004714:Endometrial Hyperplasia / Q000209:etiology*; D004967:Estrogens / Q000008:administration & dosage / Q000009:adverse effects*; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans
D003358:Cosmetics; D004967:Estrogens; D004997:Ethinyl Estradiol