title: Antileishmanial activity of 1,3,4-thiadiazolium-2-aminide in mice infected with Leishmania amazonensis.
abstract: The efficacy of two mesoionic derivatives (MI-H-H and MI-4-OCH(3)) was evaluated in CBA/J mice infected with Leishmania amazonensis. Treatment with these compounds demonstrated that the MI-4-OCH(3) derivative and the reference drug meglumine antimoniate (Glucantime) presented significant activity relative to an untreated control. No apparent hepatic or renal toxicity due to these mesoionic compounds was found.
authors.affiliation: Instituto Oswaldo Cruz/Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
authors.forename: Raquel F
authors.initials: RF
authors.lastname: Rodrigues
authors.forename: Karen S
authors.initials: KS
authors.lastname: Charret
authors.forename: Edson F
authors.initials: EF
authors.lastname: da Silva
authors.forename: Aurea
authors.initials: A
authors.lastname: Echevarria
authors.forename: Verônica F
authors.initials: VF
authors.lastname: Amaral
authors.forename: Leonor L
authors.initials: LL
authors.lastname: Leon
authors.forename: Marilene M
authors.initials: MM
authors.lastname: Canto-Cavalheiro
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use* / Q000633:toxicity; D001772:Blood Cell Count; D007894:Leishmania mexicana; D016773:Leishmaniasis, Cutaneous / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D008198:Lymph Nodes / Q000469:parasitology; D008536:Meglumine / Q000009:adverse effects / Q000627:therapeutic use; D000077485:Meglumine Antimoniate; D051379:Mice; D008808:Mice, Inbred CBA; D009569:Nitric Oxide / Q000378:metabolism; D009942:Organometallic Compounds / Q000009:adverse effects / Q000627:therapeutic use; D013329:Structure-Activity Relationship; D013830:Thiadiazoles / Q000627:therapeutic use* / Q000633:toxicity
chemical_list: C539945:1,3,4-thiadiazolium-2-aminide; D000981:Antiprotozoal Agents; D009942:Organometallic Compounds; D013830:Thiadiazoles; D009569:Nitric Oxide; D008536:Meglumine; D000077485:Meglumine Antimoniate