title: Circulating endotoxin and systemic immune activation in sporadic amyotrophic lateral sclerosis (sALS).
abstract: The present study reports elevated levels of endotoxin/lipopolysaccharide (LPS) concentrations in plasma from patients with sporadic amyotrophic lateral sclerosis (sALS) and Alzheimer's (AD) as compared to healthy controls. Levels of plasma LPS showed a significant positive correlation with degree of blood monocyte/macrophage activation in disease groups and was most elevated in patients with advanced sALS disease. There was a significant negative relationship between plasma LPS and levels of monocyte/macrophage IL-10 expression in sALS blood. These data suggest that systemic LPS levels and activated monocyte/macrophages may play significant roles in the pathogenesis of sALS.
authors.affiliation: University of California, San Francisco, San Francisco, CA 94110, USA.
authors.forename: Rongzhen
authors.initials: R
authors.lastname: Zhang
authors.forename: Robert G
authors.initials: RG
authors.lastname: Miller
authors.forename: Ron
authors.initials: R
authors.lastname: Gascon
authors.forename: Stacey
authors.initials: S
authors.lastname: Champion
authors.forename: Jonathan
authors.initials: J
authors.lastname: Katz
authors.forename: Mariselle
authors.initials: M
authors.lastname: Lancero
authors.forename: Amy
authors.initials: A
authors.lastname: Narvaez
authors.forename: Ronald
authors.initials: R
authors.lastname: Honrada
authors.forename: David
authors.initials: D
authors.lastname: Ruvalcaba
authors.forename: Michael S
authors.initials: MS
authors.lastname: McGrath
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000097:blood; D000690:Amyotrophic Lateral Sclerosis / Q000097:blood* / Q000276:immunology* / Q000473:pathology; D000704:Analysis of Variance; D004731:Endotoxins / Q000097:blood*; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D006684:HLA-DR Antigens / Q000378:metabolism; D006801:Humans; D016753:Interleukin-10 / Q000378:metabolism; D008070:Lipopolysaccharides / Q000097:blood*; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology / Q000378:metabolism
chemical_list: D004731:Endotoxins; D006684:HLA-DR Antigens; D008070:Lipopolysaccharides; D016753:Interleukin-10