Antibacterial activity of Thai medicinal plants against methicillin-resistant Staphylococcus aureus.
Methicillin-resistant Staphylococcus aureus (MRSA) is a major nosocomial pathogen which causes severe morbidity and mortality worldwide. Seventeen Thai medicinal plants were investigated for their activity against MRSA. Garcinia mangostana was identified as the most potent plant, and its activity was traced to the prenylated xanthone, alpha-mangostin (MIC and MBC values of 1.95 and 3.91 microg/ml, respectively).
Chomnawang
Mullika Traidej
MT
Department of Microbiology, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand. scmtd@mahidol.ac.th
Surassmo
Suvimol
S
Wongsariya
Karn
K
Bunyapraphatsara
Nuntavan
N
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D029762:Garcinia mangostana; D019684:Magnoliopsida; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D013785:Thailand; D044004:Xanthones / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D010936:Plant Extracts; D044004:Xanthones; C021053:mangostin