Rhodium catalysed conjugate addition of a chiral alkenyltrifluoroborate salt: the enantioselective synthesis of hermitamides A and B.
The concise enantioselective synthesis of hermitamides A and B is presented utilising a rhodium catalysed conjugate addition reaction to introduce the side chain and chiral information in a single step via an alkenyltrifluoroborate salt.
Frost
Christopher G
CG
Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK. c.g.frost@bath.ac.uk
Penrose
Stephen D
SD
Gleave
Robert
R
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D001881:Borates / Q000737:chemistry*; D002384:Catalysis; D005461:Fluorine / Q000737:chemistry*; D006868:Hydrolysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D007700:Kinetics; D010627:Phenethylamines / Q000138:chemical synthesis* / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
D000577:Amides; D001881:Borates; D007211:Indoles; D010627:Phenethylamines; C413030:hermitamide A; C413031:hermitamide B; D005461:Fluorine; D012238:Rhodium