title: MDMA-assisted psychotherapy using low doses in a small sample of women with chronic posttraumatic stress disorder.
abstract: The purpose of this study was to investigate the safety of different doses of MDMA-assisted psychotherapy administered in a psychotherapeutic setting to women with chronic PTSD secondary to a sexual assault, and also to obtain preliminary data regarding efficacy. Although this study was originally planned to include 29 subjects, political pressures led to the closing of the study before it could be finished, at which time only six subjects had been treated. Preliminary results from those six subjects are presented here. We found that low doses of MDMA (between 50 and 75 mg) were both psychologically and physiologically safe for all the subjects. Future studies in larger samples and using larger doses are needed in order to further clarify the safety and efficacy of MDMA in the clinical setting in subjects with PTSD.
authors.affiliation: Departamento de Psicología Biológica y de la Salud, Facultad de Psicología, Universidad Autónoma de Madrid, Madrid, Spain. jbouso@santpau.cat
authors.forename: José Carlos
authors.initials: JC
authors.lastname: Bouso
authors.forename: Rick
authors.initials: R
authors.lastname: Doblin
authors.forename: Magí
authors.initials: M
authors.lastname: Farré
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Alcázar
authors.forename: Gregorio
authors.initials: G
authors.lastname: Gómez-Jarabo
mesh_terms: D000328:Adult; D002908:Chronic Disease; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006213:Hallucinogens / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D011613:Psychotherapy / Q000379:methods; D012742:Sex Offenses / Q000523:psychology; D013313:Stress Disorders, Post-Traumatic / Q000628:therapy*
chemical_list: D006213:Hallucinogens; D018817:N-Methyl-3,4-methylenedioxyamphetamine