title: Tulasnein and podospirone from the coprophilous xylariaceous fungus Podosordaria tulasnei.
abstract: Tulasnein (1), a new metabolite with strong antimicrobial and weaker cytotoxic and phytotoxic activity, was isolated from culture filtrates of three strains of the xylariaceous coprophilous fungus Podosordaria tulasnei. The producing strains were identified by their rhizomorphs and by ITS rDNA sequence analysis. A second new metabolite, podospirone (2), was also produced by all three strains whereas the weakly cytotoxic (+)-3,4-anhydroshikimic acid methyl ester (3) was detected in only one strain.
authors.affiliation: Department of Biotechnology, University of Kaiserslautern, Kaiserslautern, Germany.
authors.forename: Daniela C
authors.initials: DC
authors.lastname: Ridderbusch
authors.forename: Roland W S
authors.initials: RW
authors.lastname: Weber
authors.forename: Timm
authors.initials: T
authors.lastname: Anke
authors.forename: Olov
authors.initials: O
authors.lastname: Sterner
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D005243:Feces / Q000382:microbiology; D005658:Fungi / Q000187:drug effects*; D006801:Humans; D029686:Lepidium / Q000187:drug effects; D007939:Leukemia L1210; D051379:Mice; D008826:Microbial Sensitivity Tests; D011817:Rabbits; D020037:Sordariales / Q000737:chemistry* / Q000254:growth & development / Q000302:isolation & purification; D016339:Spectrometry, Mass, Fast Atom Bombardment
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents