title: Analgesic requirements after major abdominal surgery are associated with OPRM1 gene polymorphism genotype and haplotype.
abstract: OBJECTIVE
  The association between SNPs of the human OPRM1 gene encoding the micro-opioid receptor and postoperative analgesic requirements in surgical patients remains controversial. Here, we evaluate whether any of the five tag SNPs (A118G, IVS2+G691C, IVS3+G5953A, IVS3+A8449G and TAA+A2109G) representing the four linkage disequilibrium blocks of the OPRM1 gene influences postoperative analgesic requirements.
  
  
  METHODS
  We studied 138 adult Japanese patients who underwent major open abdominal surgery under combined general and epidural anesthesia and received continuous postoperative epidural analgesia with opioids.
  
  
  RESULTS
  The 118G homozygous (GG) patients required 24-h postoperative analgesics more than 118A homozygous (AA) and heterozygous (AG) patients. Tag SNP haplotypes also were associated with 24-h postoperative analgesic requirements.
  
  
  CONCLUSIONS
  These results suggest that OPRM1 gene tag SNP genotypes and haplotypes can primarily contribute to prediction of postoperative analgesic requirements in individual patients undergoing major open abdominal surgery.
authors.affiliation: Division of Psychobiology, Tokyo Institute of Psychiatry, 2-1-8 Kamikitazawa, Setagaya-ku, Tokyo 156-8585, Japan.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Hayashida
authors.forename: Makoto
authors.initials: M
authors.lastname: Nagashima
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Satoh
authors.forename: Ryoji
authors.initials: R
authors.lastname: Katoh
authors.forename: Megumi
authors.initials: M
authors.lastname: Tagami
authors.forename: Soichiro
authors.initials: S
authors.lastname: Ide
authors.forename: Shinya
authors.initials: S
authors.lastname: Kasai
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nishizawa
authors.forename: Yasukazu
authors.initials: Y
authors.lastname: Ogai
authors.forename: Junko
authors.initials: J
authors.lastname: Hasegawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Komatsu
authors.forename: Ichiro
authors.initials: I
authors.lastname: Sora
authors.forename: Kenichi
authors.initials: K
authors.lastname: Fukuda
authors.forename: Hisashi
authors.initials: H
authors.lastname: Koga
authors.forename: Kazuo
authors.initials: K
authors.lastname: Hanaoka
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Ikeda
mesh_terms: D000005:Abdomen / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use*; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use; D013505:Digestive System Surgical Procedures; D004359:Drug Therapy, Combination; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000235:genetics / Q000517:prevention & control*; D020641:Polymorphism, Single Nucleotide; D017450:Receptors, Opioid, mu / Q000235:genetics*; D016896:Treatment Outcome
chemical_list: D000700:Analgesics; D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; C485764:OPRM1 protein, human; D017450:Receptors, Opioid, mu