title: Morphogenesis and biological significance of spindle cell transformation in a spindle cell carcinoma.
abstract: Our study investigated the histogenesis and biological significance of spindle cell carcinoma (SpCC) by comparing with moderately-well-differentiated squamous cell carcinoma (SCC) cell lines. Snail mRNA expression was readily detectable in the SpCC cell line, while E-cadherin was undetectable. SpCC cells showed lower proliferative and invasive activities than two other SCC cell lines. Culturing under air-liquid interface conditions promoted squamous cell differentiation, whereas fibroblastic differentiation after submerged culture with collagen, suggesting that the microenvironment may be a regulating factor of spindle cell differentiation as well as Snail expression and spindle cell change may not always entail the invasive behavior.
authors.affiliation: Oral Cancer Research Institute, Department of Oral Pathology, Brain Korea 21 Project, Yonsei University, College of Dentistry, 134 Shinchon-dong, Seodaemun-Gu, Seoul 120-749, Republic of Korea.
authors.forename: Eun Jung
authors.initials: EJ
authors.lastname: Kim
authors.forename: Zhong Min
authors.initials: ZM
authors.lastname: Che
authors.forename: Young Jin
authors.initials: YJ
authors.lastname: Park
authors.forename: Young Sun
authors.initials: YS
authors.lastname: Hwang
authors.forename: Ki Yeol
authors.initials: KY
authors.lastname: Kim
authors.forename: Da Woon
authors.initials: DW
authors.lastname: Jung
authors.forename: Nam Kyung
authors.initials: NK
authors.lastname: Jeon
authors.forename: Young Wook
authors.initials: YW
authors.lastname: Choi
authors.forename: Eun Ju
authors.initials: EJ
authors.lastname: Lee
authors.forename: Jin
authors.initials: J
authors.lastname: Kim
mesh_terms: D000328:Adult; D000818:Animals; D015820:Cadherins / Q000378:metabolism; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology*; D002454:Cell Differentiation; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic; D004848:Epithelium / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D008297:Male; D008648:Mesoderm / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D015820:Cadherins; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors