Design of chiral bifunctional secondary amine catalysts for asymmetric enamine catalysis.
A series of binaphthyl-based secondary amine catalysts containing various functional groups have been designed as new chiral bifunctional amine catalysts. These chiral organocatalysts have been successfully applied to several asymmetric reactions via enamine intermediates and exhibit unique reactivity and selectivity in comparison with proline and its derivatives.
Kano
Taichi
T
Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.
Maruoka
Keiji
K
D000438:Alcohols / Q000138:chemical synthesis / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry; D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D007659:Ketones / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D000438:Alcohols; D000447:Aldehydes; D000588:Amines; D007659:Ketones