title: Leishmanicidal evaluation of novel synthetic chromenes.
abstract: In the present paper, twelve chromenes were synthesized by coupling of 2,2,8,8-tetramethyl-8H-pyrano[2,3-f]chroman-4-one 1 with various aryl and benzylmagnesium chlorides. The synthetic compounds were examined for in-vitro activity against Leishmania major, and some of them displayed efficient anti-leishmanial activity. Among the compounds tested, compounds 9 (4-(2-chloro-benzylidene)-2,2,8,8-tetramethyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chromene 9a and 4-(2-chloro-benzyl)-2,2,8,8-tetramethyl-2H,8H-pyrano[2,3-f]chromene 9b) were the most active with an inhibitory activity of 73.4%.
authors.affiliation: Iranian Research Institute of Plant Protection, Tehran, Iran.
authors.forename: Babak Heidary
authors.initials: BH
authors.lastname: Alizadeh
authors.forename: Alireza
authors.initials: A
authors.lastname: Foroumadi
authors.forename: Susan K
authors.initials: SK
authors.lastname: Ardestani
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Poorrajab
authors.forename: Abass
authors.initials: A
authors.lastname: Shafiee
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D007891:Leishmania / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000981:Antiprotozoal Agents; D001578:Benzopyrans