title: Exploiting the natural metabolic diversity of Streptomyces venezuelae to generate unusual reduced macrolides.
abstract: An unusual set of reduced macrolide antibiotics was discovered by combination of organic synthesis and a biosynthetic approach using the unique metabolic diversity of Streptomyces venezuelae; two unnatural 16-membered ring macrolides are also created by employing this bio-catalyst.
authors.affiliation: Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, Republic of Korea.
authors.forename: Je Won
authors.initials: JW
authors.lastname: Park
authors.forename: Hong-Se
authors.initials: HS
authors.lastname: Oh
authors.forename: Won Seok
authors.initials: WS
authors.lastname: Jung
authors.forename: Sung Ryeol
authors.initials: SR
authors.lastname: Park
authors.forename: Ah Reum
authors.initials: AR
authors.lastname: Han
authors.forename: Yeon-Hee
authors.initials: YH
authors.lastname: Ban
authors.forename: Eun Ji
authors.initials: EJ
authors.lastname: Kim
authors.forename: Han-Young
authors.initials: HY
authors.lastname: Kang
authors.forename: Yeo Joon
authors.initials: YJ
authors.lastname: Yoon
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology; D052978:Disk Diffusion Antimicrobial Tests; D018942:Macrolides / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D005810:Multigene Family; D013302:Streptomyces / Q000235:genetics / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides