Silent cardiac dysfunction and exercise intolerance in HIV+ men receiving combined antiretroviral therapies.
Resting and exercise cardiac function, skeletal muscle oxygenation and whole-body aerobic exercise capacities were evaluated prospectively in cardiac symptom-free HIV men receiving antiretroviral therapies and in healthy controls matched for age, physical activity, smoking and body surface area. HIV patients showed resting cardiac dysfunction, altered cardiac responses to exercise and depressed exercise tolerance. Exercise stroke volume kinetics and muscle oxygenation were impaired in HIV patients, especially in those with resting diastolic dysfunction.
Thöni
Gilles J
GJ
EA 4278, Faculty of Sciences, Avignon, France. gilles.thoni@univ-montp1.fr
Schuster
Iris
I
Walther
Guillaume
G
Nottin
Stéphane
S
Vinet
Agnès
A
Boccara
Franck
F
Mauboussin
Jean-Marc
JM
Rouanet
Isabelle
I
Edérhy
Stéphane
S
Dauzat
Michel
M
Messner-Pellenc
Patick
P
Obert
Philippe
P
D000328:Adult; D015308:Anaerobic Threshold / Q000502:physiology; D023241:Antiretroviral Therapy, Highly Active; D004562:Electrocardiography; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D017079:Exercise Tolerance / Q000502:physiology; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism; D011446:Prospective Studies; D013318:Stroke Volume / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology / Q000821:virology*