title: Inhibition of fengycins on the production of fumonisin B1  from Fusarium verticillioides.
abstract: OBJECTIVE
  To understand the role of fengycins in regulating the fumonisin B1 (FB1)production of Fusarium verticillioides.
  
  
  RESULTS
  The mass ratio of FB1 to mycelia was determined in order to identify the effect of fengycins on FB1 production. It was shown that the amount of FB1 produced by unit mass mycelia decreased to 28% of the control. Results from mycelia resuspension with fengycins also demonstrated that fengycins had a potent impact on FB1 production. Gene expression patterns using quantitative reverse-transcription PCR (RT-PCR) revealed that the transcriptional levels of both FUM1 and FUM8 (coding enzymes for the generation of FB1) were down-regulated with fengycin treatment.
  
  
  CONCLUSIONS
  Fengycins could down-regulate the transcription of some key genes involved in the production of FB1, and impair FB1 synthesis by F. verticillioides.
  
  
  CONCLUSIONS
  These results further improved our understanding of fengycins as the potential candidates to control FB1 contamination in crops and food.
authors.affiliation: School of Food, Henan Institute of Science and Technology, Xinxiang, China.
authors.forename: L B
authors.initials: LB
authors.lastname: Hu
authors.forename: T
authors.initials: T
authors.lastname: Zhang
authors.forename: Z M
authors.initials: ZM
authors.lastname: Yang
authors.forename: W
authors.initials: W
authors.lastname: Zhou
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Shi
mesh_terms: D004791:Enzyme Inhibitors / Q000494:pharmacology*; D037341:Fumonisins / Q000032:analysis* / Q000378:metabolism*; D005656:Fungal Proteins / Q000096:biosynthesis; D005670:Fusarium / Q000187:drug effects* / Q000378:metabolism*; D020869:Gene Expression Profiling; D055666:Lipopeptides / Q000494:pharmacology*; D025282:Mycelium / Q000187:drug effects / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D037341:Fumonisins; D005656:Fungal Proteins; D055666:Lipopeptides; C049972:fengycin; C056933:fumonisin B1