One-pot desymmetrizing hydroformylation/carbonyl ene cyclization process: straightforward access to highly functionalized cyclohexanols.
Rapid access to highly functionalized alkylidene cyclohexanols through a one-pot desymmetrizing hydroformylation/carbonyl ene cyclization starting from simple bisalkenylcarbinols is reported. Mechanistic insight into the carbonyl ene reaction is given, highlighting the importance of hyperconjugative substituent effects.
Bigot
Aurélien
A
Institut für Organische Chemie und Biochemie, Albert-Ludwigs-Universität Freiburg, Albertstrasse 21, D-79104 Freiburg, Germany.
Breuninger
Daniel
D
Breit
Bernhard
B
D000475:Alkenes / Q000737:chemistry*; D003500:Cyclization; D003511:Cyclohexanols / Q000737:chemistry*; D004952:Esters / Q000737:chemistry; D005296:Ferrous Compounds / Q000737:chemistry; D007700:Kinetics; D000075163:Metallocenes; D000432:Methanol / Q000737:chemistry
D000475:Alkenes; D003511:Cyclohexanols; D004952:Esters; D005296:Ferrous Compounds; D000075163:Metallocenes; C004998:ferrocene; D000432:Methanol