Induction of apoptosis in leukemic cell lines treated with captopril, trandolapril and losartan: a new role in the treatment of leukaemia for these agents.
Renin-angiotensin system (RAS) in the bone marrow is related to proliferation and cellular differentiation. We investigated the effect of ACE inhibitors (ACEI) captopril (>1mM) and trandolapril (>0.05 mM) and losartan (0.2 mM) on K562 cell line and K562 transfected with c-myc, bcl-x and bcl-2 (KmycB, Kbclx and Kbcl2 respectively). RAS components, proliferation, apoptosis and c-myc expression were analyzed. ACEI and losartan inhibited cell growth, decreased c-myc expression and increased apoptosis. These effects seem to be associated to angiotensin II-induced Smad activation. This work offers a new possible line of treatment for some acute myeloid leukemias and a new area of clinical research.
De la Iglesia Iñigo
Silvia
S
Servicio de Hematología, Hospital de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, España, Spain. siglini@gobiernodecanarias.org
López-Jorge
Carmen Elsa
CE
Gómez-Casares
Maria Teresa
MT
Lemes Castellano
Angelina
A
Martín Cabrera
Pedro
P
López Brito
Jezabel
J
Suárez Cabrera
Alexia
A
Molero Labarta
Teresa
T
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D015152:Blotting, Northern; D015153:Blotting, Western; D002216:Captopril / Q000494:pharmacology*; D049109:Cell Proliferation; D016259:Genes, myc; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D020014:K562 Cells; D004915:Leukemia, Erythroblastic, Acute / Q000235:genetics / Q000473:pathology*; D019808:Losartan / Q000494:pharmacology*; D016133:Polymerase Chain Reaction
D000806:Angiotensin-Converting Enzyme Inhibitors; D007211:Indoles; C052035:trandolapril; D002216:Captopril; D019808:Losartan