A cross-sectional, mono-centric pilot study of insulin resistance in enzyme replacement therapy patients with Gaucher type I without overweight.
Insulin resistance have been demonstrated in untreated patients with Gaucher type I disease. It was implied in overweight enzyme replacement therapy (ERT) treated patients with Gaucher type I disease. In present study we investigate whether insulin resistance is presented in fourteen ERT treated patients with Gaucher type I disease and without overweight in comparison to normal subjects. This work illustrates the presence of insulin resistance in non-overweight ERT treated patients with Gaucher type I disease.
Ucar
Sema Kalkan
SK
Ege University Medical Faculty, Department of Pediatric Endocrinology and Metabolism, Bornova 35100, Turkey. semakalkan@hotmail.com
Coker
Mahmut
M
Argin
Mehmet
M
Akman
Sezin
S
Kara
Sinan
S
Simsek
Damla Goksen
DG
Darcan
Sukran
S
D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D005776:Gaucher Disease / Q000188:drug therapy* / Q000201:enzymology*; D005962:Glucosylceramidase / Q000235:genetics / Q000627:therapeutic use*; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D009154:Mutation; D050177:Overweight; D010865:Pilot Projects
D005962:Glucosylceramidase