[Clinical implications of antibiotic pharmacokinetic-pharmacodynamic parameters].
The progress in the knowledge of antibiotic action mechanisms have led to determine phamacodynamic/pharmacokinetic (PK/PD) parameters predictive of antibiotic efficacy in bacterial infections. These parameters could vary according to the antibiotic compound, the bacterial specie implicated, the localization of the infection, the severity of the disease. The serum PK/PD parameters are predictive of efficacy in several infections (respiratory, skin, bone) and become a major criterion for selecting antibiotics in clinical practice. Moreover, these PK/PD parameters are the cornerstone of pre-clinical development of antibiotics, the determination of dosage and for the establishment of breakpoints for classifying strains in the sensitive or resistant area.
Cohen
R
R
Groupe de Pathologie Infectieuse Pédiatrique de la Société Française de Pédiatrie, Hôpital Intercommunal de Créteil et Association Clinique et Thérapeutique Infantile du Val de Marne (ACTIV), Créteil, France. Robert.Cohen@wanadoo.fr
D000284:Administration, Oral; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000145:classification / Q000188:drug therapy; D001847:Bone Diseases / Q000188:drug therapy / Q000382:microbiology; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D004341:Drug Evaluation; D024881:Drug Resistance, Bacterial; D005544:Forecasting; D006801:Humans; D007275:Injections, Intravenous; D018942:Macrolides / Q000494:pharmacology; D016106:Methicillin Resistance; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D012141:Respiratory Tract Infections / Q000188:drug therapy; D012307:Risk Factors; D017192:Skin Diseases, Bacterial / Q000188:drug therapy; D013211:Staphylococcus aureus / Q000187:drug effects; D013296:Streptococcus pneumoniae / Q000187:drug effects; D013997:Time Factors; D018440:beta-Lactam Resistance; D047090:beta-Lactams / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D018942:Macrolides; D047090:beta-Lactams