Ceramide and cerebrosides from the octocoral Sarcophyton ehrenbergi.
Chemical investigation of the octocoral Sarcophyton ehrenbergi, collected at the Dongsha Islands, Taiwan, has led to the isolation of a known ceramide (1) and two new cerebrosides, sarcoehrenosides A (2) and B (4), along with three known cerebrosides (3, 5, and 6). The structures of the new compounds were established by spectroscopic and chemical methods. Sarcoehrenoside A (2) differs from previously known marine cerebrosides in that it possesses a rare alpha-glucose moiety. Compounds 1-6 were evaluated for antimicrobial activity against a small panel of bacteria and for anti-inflammatory activity using RAW 264.7 macrophages.
Cheng
Shi-Yie
SY
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan, Republic of China.
Wen
Zhi-Hong
ZH
Chiou
Shu-Fen
SF
Tsai
Chung-Wei
CW
Wang
Shang-Kewi
SK
Hsu
Chi-Hsin
CH
Dai
Chang-Feng
CF
Chiang
Michael Y
MY
Wang
Wei-Hsien
WH
Duh
Chang-Yih
CY
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002518:Ceramides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002554:Cerebrosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D021902:Enterobacter aerogenes / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012477:Salmonella enteritidis / Q000187:drug effects; D012706:Serratia marcescens / Q000187:drug effects; D012764:Shigella sonnei / Q000187:drug effects; D015008:Yersinia enterocolitica / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D002518:Ceramides; D002554:Cerebrosides