Rifalazil and derivative compounds show potent efficacy in a mouse model of H. pylori colonization.
The rifamycin rifalazil (RFZ), and derivatives (NCEs) were efficacious in a mouse model of Helicobacter pylori colonization. Select NCEs were more active in vitro and showed greater efficacy than RFZ. A systemic component contributes to efficacy.
Rothstein
David M
DM
ActivBiotics, Inc, Lexington, MA 02421, USA. drothstein@rcn.com
Mullin
Steve
S
Sirokman
Klari
K
Söndergaard
Karen L
KL
Johnson
Starrla
S
Gwathmey
Judith K
JK
van Duzer
John
J
Murphy
Christopher K
CK
D000818:Animals; D000904:Antibiotics, Antitubercular / Q000494:pharmacology*; D004195:Disease Models, Animal; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000382:microbiology; D016480:Helicobacter pylori / Q000187:drug effects / Q000254:growth & development*; D051379:Mice; D008810:Mice, Inbred C57BL; D008826:Microbial Sensitivity Tests; D012294:Rifamycins / Q000494:pharmacology*
D000904:Antibiotics, Antitubercular; D012294:Rifamycins; C068980:KRM 1648