title: Great Ormond Street Hospital for Children Registry for Congenital Melanocytic Naevi: prospective study 1988-2007. Part 2--Evaluation of treatments.
abstract: BACKGROUND
  The treatment of congenital melanocytic naevi (CMNs) has become controversial as better data on complications have been published.
  
  
  OBJECTIVE
  To determine the longer-term risks and benefits of surgery in treatment of CMNs.
  
  
  METHODS
  In this 19-year prospective study, 301 families completed yearly questionnaires about treatments and CMN changes. Forty per cent of CMNs were > 20 cm projected adult size (PAS) or multiple CMNs.
  
  
  RESULTS
  Girls were more likely to have had surgical treatments. There were no significant effects of treatment on the incidence of adverse clinical outcomes, although the numbers for melanoma were small. The majority of untreated CMNs lightened spontaneously during the follow-up period. Surgical treatment and satellites at birth were independently significantly associated with reported darkening of the CMN over the follow-up period. However there was no absolute measurement of final colour. Surgical treatment was associated with decreasing hairiness of the CMN over the follow-up period. PAS was associated with increasing hairiness. Excision with tissue expanders and PAS were significantly associated with an increased incidence of new satellite lesions. A proportion of patients reported new pigmentation in previously unaffected skin at the edge of a treated area, the majority after complete excision. There was a high level of satisfaction with surgery in the < 20 cm group and in those with facial CMNs. This was significantly reduced with increasing PAS.
  
  
  CONCLUSIONS
  There is no evidence here that surgery reduces the incidence of adverse clinical outcomes in childhood. The natural history of the majority of untreated CMNs is to lighten spontaneously, whereas some treatments may cause adverse effects.
authors.affiliation: Dermatology Department, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London WC1N 3JH, UK. v.kinsler@ich.ucl.ac.uk
authors.forename: V A
authors.initials: VA
authors.lastname: Kinsler
authors.forename: J
authors.initials: J
authors.lastname: Birley
authors.forename: D J
authors.initials: DJ
authors.lastname: Atherton
mesh_terms: D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D004954:Esthetics / Q000523:psychology; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008545:Melanoma / Q000151:congenital / Q000473:pathology / Q000601:surgery*; D009508:Nevus, Pigmented / Q000151:congenital / Q000473:pathology / Q000601:surgery*; D010641:Phenotype; D010858:Pigmentation; D011446:Prospective Studies; D012307:Risk Factors; D012878:Skin Neoplasms / Q000151:congenital / Q000473:pathology / Q000601:surgery*; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D006113:United Kingdom