title: Results of lung transplantation in patients with chronic obstructive pulmonary disease.
abstract: OBJECTIVE
  The objective of this study was to evaluate the results and survival rates of patients who underwent lung transplantation (LT) to treat chronic obstructive pulmonary disease (COPD).
  
  
  METHODS
  We performed a retrospective analysis of 63 patients with COPD who underwent LT between 1996 and 2007. Our statistical analysis was based on descriptive statistics and survival analysis (Kaplan-Meier and log-rank test).
  
  
  RESULTS
  Sixty-three LTs were performed in 53 male and 10 female patients with COPD. Twenty-eight LTs were unipulmonary and 35 were bipulmonary. Four cases required extracorporeal circulation. Surgical complications arose in 18 cases. There were 3 cases of intraoperative death as a result of cardiac failure. The most frequent long-term complications were hypertension (39.7%), renal failure (42.9%), and neoplasms (20.6%). Overall survival times (mean, 2553 days) were 75.9%, 74.15%, 65.67%, 55.87%, and 42.05% at 1, 2, 3, 5, and 10 years, respectively. No differences were observed in survival according to the following: donor age >30 years (P = 8), type of transplantation (unilateral vs bilateral; P = .57), donor intubation time >48 hours (P = .2), or donor oxygenation index <450 mm Hg (P = .3).
  
  
  CONCLUSIONS
  No differences were observed in survival according to the type of transplantation (unilateral vs bilateral), which suggests that unipulmonary transplantation is a reasonable option, given that this procedure reduces both the ischemia time compared with bilateral transplantation and the surgery time, as well as offering more efficient use of donor organs.
authors.affiliation: Thoracic Surgery and Lung Transplantation Service, Reina Sofia University Hospital, Department of Medico-Surgical Specialities, University of Cordoba, Cordoba, Spain. joseravich@hotmail.com
authors.forename: J R
authors.initials: JR
authors.lastname: Cano
authors.forename: F J
authors.initials: FJ
authors.lastname: Algar
authors.forename: F
authors.initials: F
authors.lastname: Cerezo
authors.forename: P
authors.initials: P
authors.lastname: Moreno
authors.forename: D
authors.initials: D
authors.lastname: Espinosa
authors.forename: A
authors.initials: A
authors.lastname: Alvarez
authors.forename: C
authors.initials: C
authors.lastname: Baamonde
authors.forename: F
authors.initials: F
authors.lastname: Santos
authors.forename: A
authors.initials: A
authors.lastname: Salvatierra
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D016040:Lung Transplantation / Q000401:mortality / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000601:surgery*; D012189:Retrospective Studies; D016019:Survival Analysis; D017741:Survivors; D013997:Time Factors; D014019:Tissue Donors / Q000706:statistics & numerical data; D055815:Young Adult