title: Short- and long-term follow-up of glomerular and tubular renal markers of kidney function in hyperthyroid cats after treatment with radioiodine.
abstract: Hyperthyroidism can mask co-existing chronic kidney disease (CKD). Previous studies showed that post-treatment renal azotemia can be predicted by pre-treatment assessment of glomerular filtration rate (GFR). We hypothesized that treatment of hyperthyroidism may have different effects on glomerular and tubular function and these changes might be predicted by additional pre-treatment variables than GFR. Serum total T4 (TT4), creatinine and blood urea nitrogen (BUN), blood pressure (BP), body weight (BW), GFR, urine specific gravity (USG), urinary protein/creatinine ratio (UPC) and retinol binding protein/creatinine ratio (uRBP/c) were evaluated before and 1, 4, 12 and 24 weeks post-treatment with radioiodine ((131)I) in 21 non-azotemic hyperthyroid cats. Cats were divided 24 weeks post-treatment into group A (normal kidney function, n=16) and group B (impaired kidney function, n=5). Serum TT4, GFR, UPC and uRBP/c decreased significantly after treatment for the complete group and group A (P<0.05), although GFR and uRBP/c did not change in group B. Serum creatinine and BW increased significantly from 1 week after treatment (P<0.05). There was no change in BUN, USG or BP. Pre-treatment serum TT4, GFR and USG differed significantly between group A and B (P<0.05). GFR at 4 weeks after treatment and maximum decrease in GFR could be partially predicted by a formula using pre-treatment GFR, serum TT4, serum creatinine, BUN and/or USG. Significant changes in kidney function occur within 4 weeks post-treatment and none thereafter. Pre-treatment measurement of GFR, USG and serum TT4 can have possible predictive value regarding the development of post-treatment renal azotemia.
authors.affiliation: Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
authors.forename: I
authors.initials: I
authors.lastname: van Hoek
authors.forename: H P
authors.initials: HP
authors.lastname: Lefebvre
authors.forename: K
authors.initials: K
authors.lastname: Peremans
authors.forename: E
authors.initials: E
authors.lastname: Meyer
authors.forename: S
authors.initials: S
authors.lastname: Croubels
authors.forename: E
authors.initials: E
authors.lastname: Vandermeulen
authors.forename: H
authors.initials: H
authors.lastname: Kooistra
authors.forename: J H
authors.initials: JH
authors.lastname: Saunders
authors.forename: D
authors.initials: D
authors.lastname: Binst
authors.forename: S
authors.initials: S
authors.lastname: Daminet
mesh_terms: D000818:Animals; D053099:Azotemia / Q000175:diagnosis / Q000209:etiology; D015415:Biomarkers / Q000032:analysis*; D001806:Blood Urea Nitrogen; D001835:Body Weight; D002371:Cat Diseases / Q000532:radiotherapy*; D002415:Cats; D003404:Creatinine / Q000097:blood / Q000652:urine; D005919:Glomerular Filtration Rate; D006980:Hyperthyroidism / Q000150:complications / Q000532:radiotherapy / Q000662:veterinary*; D007457:Iodine Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use*; D007674:Kidney Diseases / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D007678:Kidney Glomerulus; D007684:Kidney Tubules; D011507:Proteinuria; D013974:Thyroxine / Q000097:blood
chemical_list: D015415:Biomarkers; D007457:Iodine Radioisotopes; D003404:Creatinine; D013974:Thyroxine