title: Osteosarcoma arising in a long-standing uterine leiomyoma: a case report and literature review.
abstract: The authors present the first case of a pure osteosarcoma arising in a long-standing uterine leiomyoma along with a literature review of all heterologous sarcomas arising in uterine leiomyoma. Most cases present with abnormal vaginal bleeding and symptoms related to a rapidly enlarged pelvic mass in postmenopausal women with a long-standing history of uterine leiomyoma. The histological finding of the case in this study revealed a relatively well-circumscribed tumor with a peripheral ring of leiomyoma and a central osteosarcoma. The case in this study further supported a possible pathogenesis involving the p53 gene. The prognosis may be better with low-stage tumor; however, cases with advanced stages, larger tumor size at presentation, and histological type of epithelioid angiosarcoma had poorer prognosis despite aggressive therapy.
authors.affiliation: Department of Pathology and Laboratory Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: Ren Ching
authors.initials: RC
authors.lastname: Wang
authors.forename: Mei Ching
authors.initials: MC
authors.lastname: Wen
authors.forename: John
authors.initials: J
authors.lastname: Wang
authors.forename: Shin Chu
authors.initials: SC
authors.lastname: Ho
authors.forename: Yee Jee
authors.initials: YJ
authors.lastname: Jan
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000473:pathology*; D008875:Middle Aged; D012516:Osteosarcoma / Q000473:pathology*; D014594:Uterine Neoplasms / Q000473:pathology*