A case of non-Hodgkin's lymphoma primary arising in both adrenal glands associated with adrenal failure.
It is known that adrenal insufficiency is one of the complications in primary adrenal lymphoma, especially those with bilateral adrenal involvement. A 73-year-old man was referred for general fatigue and high fever to the nearest hospital. The patient was transferred to our hospital for evaluation of bilateral adrenal tumors and hyponatremia. He was diagnosed as having non-Hodgkin's lymphoma (NHL) with primaries arising in both adrenal glands. Primary adrenal lymphoma (PAL) is a rare extra-nodal NHL. Although an appropriate treatment of this disease has not been established, our case has demonstrated that the combination of rituximab and THP-COP chemotherapy could be administered, and that it improved clinical manifestations. This case raises the suggestion that malignant lymphoma should be suspected in patients with bilateral adrenal tumors that present with progressive adrenal insufficiency.
Nishiuchi
Takamasa
T
Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa, 761-0793, Japan.
Imachi
Hitomi
H
Fujiwara
Mako
M
Murao
Koji
K
Onishi
Hiroaki
H
Kiguchi
Tohru
T
Takimoto
Hidetaka
H
Kushida
Yoshio
Y
Haba
Reiji
R
Ishida
Toshihiko
T
D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D000309:Adrenal Insufficiency / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D000368:Aged; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000150:complications / Q000175:diagnosis* / Q000473:pathology