Chronic ultra-low dose follicle-stimulating hormone regimen for patients with polycystic ovary syndrome: one click, one follicle, one pregnancy.
In the present study we demonstrate that using a weekly incremental dose as small as 8.3 IU of FSH in a chronic ultra low-dose step-up protocol for anovulatory polycystic ovary syndrome (PCOS) produces very good clinical results with an excellent safety profile. Although using a significantly lower incremental (16.6% of the initial dose) and total (622 +/- 286 IU) gonadotropin dose, compared with the widely used and accepted low-dose gonadotropins regimen, a clinical pregnancy rate (PR) of almost 30% per started cycle has been achieved with just one twin gestation and no case of even mild ovarian hyperstimulation syndrome (OHSS).
Orvieto
Raoul
R
Danielli Medical Center, Givataim, Israel. raoulo@barzi.health.gov.il
Homburg
Roy
R
D000328:Adult; D000858:Anovulation / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D005260:Female; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage*; D006801:Humans; D006080:Ovarian Follicle / Q000502:physiology*; D010062:Ovulation Induction / Q000379:methods; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy*; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate
D005640:Follicle Stimulating Hormone