title: Extracorporeal pumpless interventional lung assist in clinical practice: determinants of efficacy.
abstract: Respiratory acidosis can become a serious problem during protective ventilation of severe lung failure. A pumpless arteriovenous interventional lung assist (iLA) for extracorporeal carbon dioxide removal has been used increasingly to control critical respiratory situations. The present study sought to evaluate the factors determining the efficacy of iLA and calculate its contribution to gas exchange. In a cohort of 96 patients with severe acute respiratory distress syndrome, haemodynamic parameters, oxygen consumption and carbon dioxide production as well as gas transfer through the iLA were analysed. The measurements demonstrated a significant dependency of blood flow via the iLA device on cannula size (mean+/-sd 1.59+/-0.52 L x min(-1) for 15 French (Fr), 1.94+/-0.35 L x min(-1) for 17 Fr, and 2.22 +/-0.45 L x min(-1) for 19 Fr) and on mean arterial pressure. Oxygen transfer capacity averaged 41.7+/-20.8 mL x min(-1), carbon dioxide removal was 148.0+/-63.4 mL x min(-1). Within two hours of iLA treatment, arterial oxygen partial pressure/inspired oxygen fraction ratio increased significantly and a fast improvement in arterial carbon dioxide partial pressure and pH was observed. Interventional lung assist eliminates approximately 50% of calculated total carbon dioxide production with rapid normalisation of respiratory acidosis. Despite limited contribution to oxygen transfer it may allow a more protective ventilation in severe respiratory failure.
authors.affiliation: Department of Internal Medicine II, University Hospital of Regensburg, Franz-Josef-Strauss Allee 11, 93053 Regensburg, Germany. thomas.mueller@klinik.uni-regensburg.de
authors.forename: T
authors.initials: T
authors.lastname: Müller
authors.forename: M
authors.initials: M
authors.lastname: Lubnow
authors.forename: A
authors.initials: A
authors.lastname: Philipp
authors.forename: T
authors.initials: T
authors.lastname: Bein
authors.forename: A
authors.initials: A
authors.lastname: Jeron
authors.forename: A
authors.initials: A
authors.lastname: Luchner
authors.forename: L
authors.initials: L
authors.lastname: Rupprecht
authors.forename: M
authors.initials: M
authors.lastname: Reng
authors.forename: J
authors.initials: J
authors.lastname: Langgartner
authors.forename: C E
authors.initials: CE
authors.lastname: Wrede
authors.forename: M
authors.initials: M
authors.lastname: Zimmermann
authors.forename: D
authors.initials: D
authors.lastname: Birnbaum
authors.forename: C
authors.initials: C
authors.lastname: Schmid
authors.forename: G A J
authors.initials: GA
authors.lastname: Riegger
authors.forename: M
authors.initials: M
authors.lastname: Pfeifer
mesh_terms: D000142:Acidosis, Respiratory; D002245:Carbon Dioxide / Q000737:chemistry / Q000378:metabolism; D015331:Cohort Studies; D015199:Extracorporeal Membrane Oxygenation / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008168:Lung / Q000473:pathology*; D010100:Oxygen / Q000737:chemistry; D010101:Oxygen Consumption; D011312:Pressure; D012121:Respiration, Artificial / Q000295:instrumentation* / Q000379:methods; D012128:Respiratory Distress Syndrome / Q000503:physiopathology* / Q000628:therapy; D012131:Respiratory Insufficiency / Q000628:therapy; D012306:Risk
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen