title: Preserved systolic ventricular function heart failure patients referred to a division of internal medicine.
abstract: BACKGROUND
  At least 70% of patients with heart failure (HF) are referred to departments of internal medicine. Some 40-50% have preserved systolic ventricular function (PSVF; LVEF > 0.45). The aim of this study was to evaluate survival and prognostic value of several functional parameters in PSVF-HF patients admitted to a department of internal medicine.
  
  
  METHODS
  Eighty-two consecutive patients hospitalized between January 1 and December 31, 2001 (44 men and 38 women, mean age 63.7 years) were followed up for a mean period of 37 months. The severity of symptoms at admission was assessed by NYHA classification. Twenty-five patients were in NYHA class I, 43 in II, and 14 in III-IV. All patients underwent chest X-ray, echocardiogram, and a 6-minute walking test.
  
  
  RESULTS
  Seventeen patients (20.7%) died, 16 of cardiovascular causes and 1 of cancer. Survival was not affected by etiology, sex, age, left ventricular ejection fraction (LVEF), LV filling pattern, or pulmonary artery pressure. With univariate analysis, NYHA class at admission was the strongest predictor of death. Distance covered after the 6-minute walking test was also related to survival. The Cox stepwise regression model showed that only NYHA class at admission (p < 0.05) was significantly related to survival.
  
  
  CONCLUSIONS
  During a 3-year follow-up, mortality in PSVF-HF patients referred to a department of internal medicine is close to 7% per year. A high NYHA class at admission and decreased functional capacity (i.e., distance walked at 6 min < 350 m) are related to a worse prognosis.
authors.affiliation: Department of Internal Medicine, AOU Careggi, Firenze, Italy. c.rostagno@katamail.com
authors.forename: Carlo
authors.initials: C
authors.lastname: Rostagno
authors.forename: Gabriele
authors.initials: G
authors.lastname: Rosso
authors.forename: Francesco
authors.initials: F
authors.lastname: Puggelli
authors.forename: Gian Franco
authors.initials: GF
authors.lastname: Gensini
mesh_terms: D000328:Adult; D000368:Aged; D009202:Cardiomyopathies / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D054144:Heart Failure, Diastolic / Q000175:diagnosis / Q000401:mortality* / Q000503:physiopathology*; D006801:Humans; D007388:Internal Medicine / Q000706:statistics & numerical data*; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012017:Referral and Consultation / Q000706:statistics & numerical data*; D013599:Systole; D016277:Ventricular Function, Left