Preparation and stability of voriconazole eye drop solution.
The combined systemic and topical administration of voriconazole has successfully been used to treat keratomycosis. Because no voriconazole eye drop product is commercially available, we prepared a sterile eye drop solution (10 mg/ml). Voriconazole remains stable over 30 days, providing an eye drop solution suitable for use for the topical treatment of fungal keratitis.
Dupuis
Antoine
A
Centre Hospitalier Universitaire de Poitiers, France. Antoine.Dupuis@univ-poitiers.fr
Tournier
Nicolas
N
Le Moal
Gwenaël
G
Venisse
Nicolas
N
D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding; D004355:Drug Stability; D005079:Excipients; D006863:Hydrogen-Ion Concentration; D009883:Ophthalmic Solutions; D011743:Pyrimidines / Q000008:administration & dosage / Q000494:pharmacology*; D014230:Triazoles / Q000008:administration & dosage / Q000494:pharmacology*; D065819:Voriconazole
D000935:Antifungal Agents; D005079:Excipients; D009883:Ophthalmic Solutions; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole