title: Does Helicobacter pylori play a role in etiology of nasal polyposis?
abstract: OBJECTIVE
  Investigation of the possible relation between nasal polyposis (NP) and Helicobacter pylori (HP).
  
  
  METHODS
  Biopsy specimens of 25 patients with NP were evaluated. There were 16 men and 9 women enrolled in the study (NP) group. There were 10 men and 4 women in the control group. Campylobacter-like organism (CLO) test, immunohistochemical examination on nasal polyp tissue biopsy specimens and serological analysis were used for detecting HP.
  
  
  RESULTS
  There was only one (4%) positive NP case for CLO test. There were six cases in the study group with positive anti HP IgG test. Two control nasal mucosa were CLO positive. There were three cases in control group with positive anti HP IgG. There were no positive cases with positive anti IgM HP regarding both the study and the control groups. The immunohistochemical examination of the specimens taken from the patients with NP and control patients revealed that all patients were negative for HP. Positive CLO test and serologic test ratios were not statistically significant between NP and control groups.
  
  
  CONCLUSIONS
  The results of this study did not confirm other investigators. The suggested role of HP in the previous reports regarding NP may demonstrate transient occurrence of HP. It may not be treated as a possible etiological factor in NP.
authors.affiliation: Department of Otorhinolaryngology, School of Medicine, Mersin University, Ihsaniye Mah. 123, Cadde, 4931 Sokak, TR-33079 Mersin, Turkey. cozcan@mersin.edu.tr
authors.forename: Cengiz
authors.initials: C
authors.lastname: Ozcan
authors.forename: Ayşe
authors.initials: A
authors.lastname: Polat
authors.forename: Feza
authors.initials: F
authors.lastname: Otağ
authors.forename: Kemal
authors.initials: K
authors.lastname: Görür
mesh_terms: D000328:Adult; D000368:Aged; D002167:Campylobacter / Q000302:isolation & purification; D005260:Female; D016481:Helicobacter Infections / Q000150:complications* / Q000175:diagnosis; D016480:Helicobacter pylori; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000382:microbiology; D009298:Nasal Polyps / Q000378:metabolism / Q000382:microbiology*; D012698:Serologic Tests; D013194:Staining and Labeling; D055815:Young Adult