BDNF gene: functional Val66Met polymorphism in mood disorders and schizophrenia.
The brain-derived neurotrophic factor (BDNF) gene has become a candidate gene for molecular-genetic studies of mood disorders and schizophrenia, and also for pharmacogenomics of drugs used in the treatment of these conditions, such as mood-stabilizers in bipolar mood disorder, antidepressants in depression, and antipsychotics in schizophrenia. It has been demonstrated that the functional Val66Met polymorphism of the gene can be associated with a number of clinical and pharmacological phenomena in these illnesses.
Rybakowski
Janusz K
JK
Department of Adult Psychiatry, Poznan University of Medical Science, Szpitalna 27/33, 60-572 Poznan, Poland. rybakows@wlkp.top.pl
D014150:Antipsychotic Agents / Q000627:therapeutic use; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D019964:Mood Disorders / Q000188:drug therapy / Q000235:genetics*; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics*
D014150:Antipsychotic Agents; D019208:Brain-Derived Neurotrophic Factor