[The effects on growth velocity of inhaled corticosteroids therapy in children with asthma].
BACKGROUND
Studies have demonstrated growth suppressive effects in case of use of inhaled corticosteroids therapy.


OBJECTIVE
To assess growth velocity during 12 months of inhaled corticosteroids therapy in children with persistent asthma.


METHODS
Measurements of height were performed in the study group including 109 children with mild and moderately severe, persistent asthma, after 12 month with low or medium doses of either beclomethasone dipropionate or fluticasone propionate. The results were compared with a control group including 71 children with asthma treated with montelukast or cromones.


RESULTS
There were statistically significant differences between study group and controls concerning the growth velocity after 3 months of inhaled glucocorticoid therapy (GSI).


CONCLUSIONS
The velocity of growth was decreased in the study group compared to controls after 3 months of treatment, but the differences become unsignificant after 12 months of therapy.
Crişan
Marilena
M
Spitalul Clinic de Copii, Oradea. marilenacrisan@yahoo.com
Nanulescu
Mircea
M
Panţa
Paraschiva Cherecheş
PC
Popa
Mirela
M
Farcău
Mihaela
M
Mureşan
Mariana
M
Ichim
Gabriela
G
D000280:Administration, Inhalation; D000730:Androstadienes / Q000008:administration & dosage / Q000009:adverse effects; D001249:Asthma / Q000188:drug therapy*; D001507:Beclomethasone / Q000008:administration & dosage / Q000009:adverse effects; D001827:Body Height / Q000187:drug effects*; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000009:adverse effects; D016022:Case-Control Studies; D002648:Child; D004359:Drug Therapy, Combination; D005260:Female; D000068298:Fluticasone; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000009:adverse effects*; D006801:Humans; D008297:Male; D012383:Romania
D000730:Androstadienes; D001993:Bronchodilator Agents; D005938:Glucocorticoids; D000068298:Fluticasone; D001507:Beclomethasone