title: Careful cardiovascular screening and follow-up of women with Turner syndrome before and during pregnancy is necessary to prevent maternal mortality.
abstract: OBJECTIVE
  To report the fatal outcome of a woman with Turner syndrome (TS) undergoing assisted reproductive technology (ART).
  
  
  METHODS
  Case report.
  
  
  METHODS
  Reproductive medicine center.
  
  
  METHODS
  A 33-year-old woman with TS.
  
  
  METHODS
  Screening before oocyte donation and treatment of aortic dissection occurring at term pregnancy.
  
  
  METHODS
  Evaluation of cardiovascular risk.
  
  
  RESULTS
  After a normal cardiac screening, a woman with TS got pregnant as a result of oocyte donation. At 16 weeks of gestation, a bicuspid aortic valve was detected and associated with moderate aortic root dilation. Aortic dissection was diagnosed at 38 weeks of gestation, which required emergent cesarean delivery and aortic root replacement. Despite surgical treatment, early maternal death was recorded.
  
  
  CONCLUSIONS
  Careful cardiac screening and close follow-up before and during pregnancy are necessary in patients with TS.
authors.affiliation: Laboratoire de Biologie de la Reproduction-CECOS, Groupe Hospitalier Cochin- Saint-Vincent de Paul, Assistance Publique-Hôpitaux de Paris, Université René Descartes, Paris, France. celine.chalas@cch.aphp.fr
authors.forename: Celine Chalas
authors.initials: CC
authors.lastname: Boissonnas
authors.forename: Celine
authors.initials: C
authors.lastname: Davy
authors.forename: Marie
authors.initials: M
authors.lastname: Bornes
authors.forename: Leila
authors.initials: L
authors.lastname: Arnaout
authors.forename: Christophe
authors.initials: C
authors.lastname: Meune
authors.forename: Vassilis
authors.initials: V
authors.lastname: Tsatsatris
authors.forename: Alexandre
authors.initials: A
authors.lastname: Mignon
authors.forename: Pierre
authors.initials: P
authors.lastname: Jouannet
mesh_terms: D000328:Adult; D000784:Aortic Dissection / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control / Q000601:surgery; D001014:Aortic Aneurysm / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control / Q000601:surgery; D001019:Aortic Rupture / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control / Q000601:surgery; D001021:Aortic Valve / Q000473:pathology* / Q000601:surgery; D019917:Blood Vessel Prosthesis Implantation; D002585:Cesarean Section; D017548:Echocardiography, Transesophageal; D004562:Electrocardiography; D004624:Embryo Transfer; D017809:Fatal Outcome; D005260:Female; D005307:Fertilization in Vitro; D005317:Fetal Growth Retardation / Q000175:diagnosis / Q000209:etiology; D006340:Heart Rate, Fetal; D006349:Heart Valve Diseases / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control / Q000601:surgery; D006801:Humans; D050498:Live Birth; D018587:Oocyte Donation; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control / Q000601:surgery; D027724:Reproductive Techniques, Assisted; D014424:Turner Syndrome / Q000150:complications*