title: Effect of heme oxygenase–endogenous carbon monoxide on mortality during septic shock in rats.
abstract: OBJECTIVE
  To investigate the effect of HO–CO on mortality during septic shock in rats.
  
  
  METHODS
  Eighty rats were randomly divided into group-control, group ZnPP-IX, group SS, and group LZ.
  
  
  RESULTS
  Death was significantly lower in group SS than in group LZ (P < 0.05). The MAP was significantly higher in the group LZ than in the group SS (P < 0.05). ALT, AST, Cr and BUN, MDA, and the lung EB contents, were significantly lower in the group SS than that in the group LZ (all P < 0.05). And CO and SOD activities were significantly higher in group SS than that in the group LZ (all P < 0.05). HO-1 mRNA, and HO-1 protein were significantly lower in the group LZ than in the group SS (P < 0.05), whereas HO-2 mRNA, and HO-2 protein were not significantly different among four groups (all P > 0.05).
  
  
  CONCLUSIONS
  The increased oxidative stress and end-organ damage is related to mortality during septic shock; while the hypotension partly contributing to HO-1 protein and CO has no obvious relation with it.
authors.affiliation: Department of Anesthesiology, Tianjin Nankai Hospital, China. jianboyu99@yahoo.com.cn
authors.forename: J-b
authors.initials: JB
authors.lastname: Yu
authors.forename: S-l
authors.initials: SL
authors.lastname: Yao
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001806:Blood Urea Nitrogen; D002248:Carbon Monoxide / Q000097:blood / Q000502:physiology*; D003404:Creatinine / Q000097:blood; D006419:Heme Oxygenase (Decyclizing) / Q000378:metabolism / Q000502:physiology*; D051547:Heme Oxygenase-1 / Q000378:metabolism / Q000502:physiology*; D007022:Hypotension / Q000503:physiopathology*; D008070:Lipopolysaccharides; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology; D011524:Protoporphyrins / Q000494:pharmacology; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012772:Shock, Septic / Q000139:chemically induced / Q000503:physiopathology*; D013482:Superoxide Dismutase / Q000378:metabolism; D015854:Up-Regulation
chemical_list: D008070:Lipopolysaccharides; D011524:Protoporphyrins; D012333:RNA, Messenger; C017803:zinc protoporphyrin; D008315:Malondialdehyde; D002248:Carbon Monoxide; D003404:Creatinine; D006419:Heme Oxygenase (Decyclizing); D051547:Heme Oxygenase-1; C105245:heme oxygenase-2; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase