11-Phenyl-[b,e]-dibenzazepine compounds: novel antitumor agents.
A series of 11-phenyl-[b,e]-dibenzazepine compounds were synthesized and shown to be inhibitors of tumor cell proliferation with IC(50) values ranging from submicromolar to micromolar concentrations. Flow cytometric analyses of several active compounds demonstrated inhibition of cell cycle progression at the G(0)-G(1) phase transition resulting in G(0)-G(1) arrest.
Al-Qawasmeh
Raed A
RA
Department of Chemistry, The University of Jordan, Amman, Jordan.
Lee
Yoon
Y
Cao
Ming-Yu
MY
Gu
Xiaoping
X
Viau
Stéphane
S
Lightfoot
Jeff
J
Wright
Jim A
JA
Young
Aiping H
AH
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003984:Dibenzazepines / Q000138:chemical synthesis* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D016193:G1 Phase; D006801:Humans; D020128:Inhibitory Concentration 50; D016192:Resting Phase, Cell Cycle; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D003984:Dibenzazepines