Ms identification of microcystin-LR chlorination by-products.
Drinking water disinfection by chlorine is known to reduce concentration of microcystin, but compounds formed are rarely considered. In this work the chlorination of microcystin-LR has been studied by monitoring reactants consumption and reaction products using the linear trap quad-Orbitrap (LTQ-Orbitrap) technology. Microcystin-LR was totally transformed within 2 min, meanwhile chlorine was consumed until 30 min with a rate of 12 mol per mol of toxin. Four new by-products of microcystin-LR were identified as well as their isomers: monochloro-microcystin, monochloro-dihydroxy-microcystin, dichloro-dihydroxy-microcystin and trichloro-hydroxy-microcystin. In addition, four new isomers were also observed, corresponding to the dihydroxy-microcystin already known. Besides, another compound previously observed was identified as monochloro-hydroxy-microcystin.
Merel
Sylvain
S
Environment and Health Laboratory (LERES), School of Public Health (EHESP), Avenue Professeur Léon-Bernard, CS 74312, 35043 Rennes Cedex, France.
LeBot
Barbara
B
Clément
Michel
M
Seux
René
R
Thomas
Olivier
O
D054879:Halogenation; D008387:Marine Toxins; D013058:Mass Spectrometry; D052998:Microcystins / Q000737:chemistry*; D013237:Stereoisomerism; D018508:Water Purification / Q000379:methods
D008387:Marine Toxins; D052998:Microcystins; C057862:cyanoginosin LR