title: Antibacterial novel phenolic diterpenes from Podocarpus macrophyllus D. Don.
abstract: Two new sempervirol type diterpenes, inumakiols A, B, and six new totarol type diterpenes, inumakiols C-H, were isolated from a methanolic extract of bark of Podocarpus macrophyllus (Podocarpaceae), along with one known abietane, two known totarol type diterpenes, and one known totarol type diterpene dimer. The structures of the new compounds were elucidated by the spectroscopic methods. Some of them possessed antibacterial activity against oral pathogenic microorganisms with minimum inhibitory concentration (MIC) values ranging from 3.1 to 25 ppm.
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo, Japan.
authors.forename: Kimihiko
authors.initials: K
authors.lastname: Sato
authors.forename: Keito
authors.initials: K
authors.lastname: Sugawara
authors.forename: Hirono
authors.initials: H
authors.lastname: Takeuchi
authors.forename: Hyun-Sun
authors.initials: HS
authors.lastname: Park
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Akiyama
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Koyama
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Aoyagi
authors.forename: Koichi
authors.initials: K
authors.lastname: Takeya
authors.forename: Takanori
authors.initials: T
authors.lastname: Tsugane
authors.forename: Susumu
authors.initials: S
authors.lastname: Shimura
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D009055:Mouth / Q000382:microbiology; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D010944:Plants / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes; D010936:Plant Extracts; C534248:inumakiol A; C534249:inumakiol B