title: Pyridinium 1,1'-binaphthyl-2,2'-disulfonates as highly effective chiral Brønsted acid-base combined salt catalysts for enantioselective Mannich-type reaction.
abstract: We have established, for the first time, a practical synthesis of chiral 1,1'-binaphthyl-2,2'-disulfonic acid (BINSA 1) from inexpensive BINOL. An efficient enantioselective catalysis in the Mannich-type reactions of diketones and ketoester equivalents with aldimines was developed using chiral 1-achiral 2,6-diarylpyridine (2) combined salts, which acted as convenient chiral tailor-made Brønsted acid-base organocatalysts in situ.
authors.affiliation: Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa, Nagoya, 464-8603, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Hatano
authors.forename: Toshikatsu
authors.initials: T
authors.lastname: Maki
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Moriyama
authors.forename: Manabu
authors.initials: M
authors.lastname: Arinobe
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Ishihara