Albumin liver dialysis as pregnancy-saving procedure in cholestatic liver disease and intractable pruritus.
Progressive familial intrahepatic cholestasis type 3 (PFIC3) is a rare cholestatic liver disease. Such liver disease can get worse by female hormone disorder. Albumin dialysis or Molecular Adsorbent Recirculating System (MARS) has been reported to reverse severe cholestasis-linked pruritus. Here, we report the first use of MARS during a spontaneous pregnancy and its successful outcome in a patient with PFIC3 and intractable pruritus. Albumin dialysis could be considered as a pregnancy-saving procedure in pregnant women with severe cholestasis and refractory pruritus.
Lemoine
Maud
M
Service d'Hepatologie, Hospital Jean-Verdier, Avenue du 14 juillet, Bondy 93140, France. maud.lemoine@jvr.aphp.fr
Revaux
Aurelie
A
Francoz
Claire
C
Ducarme
Guillaume
G
Brechignac
Sabine
S
Jacquemin
Emmanuel
E
Uzan
Michele
M
Ganne-Carrie
Nathalie
N
D000418:Albumins / Q000627:therapeutic use*; D002585:Cesarean Section; D002756:Cholagogues and Choleretics / Q000009:adverse effects; D002780:Cholestasis, Intrahepatic / Q000150:complications / Q000628:therapy*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D050498:Live Birth; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000628:therapy*; D011537:Pruritus / Q000209:etiology / Q000628:therapy*; D006435:Renal Dialysis; D016060:Sorption Detoxification / Q000379:methods*; D014580:Ursodeoxycholic Acid / Q000009:adverse effects; D055815:Young Adult
D000418:Albumins; D002756:Cholagogues and Choleretics; D014580:Ursodeoxycholic Acid