Leukocyte adhesion defect.
Leukocyte adhesion defect (LAD) is a rare, autosomal recessive primary immunodeficiency disorder of phagocytes, in which there is defective aggregation at the site of infection due to the absence of surface integrins. Diagnosis is based primarily on flowcytometric analysis of neutrophils for the surface expression of CD11, CD18 and CD15s. We describe here a case of a 7-months-old boy who presented with a characteristic history of recurrent infections, marked leukocytosis and delayed separation of umbilical cord. The diagnosis was established by demonstration of the absence of integrins on the surface of patient's neutrophils by flowcytometric analysis.
Tipu
Hamid Nawaz
HN
Armed Forces Institute of Pathology, Rawalpindi.
Tahir
Awais
A
Ahmed
Tahir Aziz
TA
Hazir
Tabish
T
Waqar
Muhammad Amin
MA
D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005434:Flow Cytometry; D006801:Humans; D007223:Infant; D018370:Leukocyte-Adhesion Deficiency Syndrome / Q000175:diagnosis*; D008297:Male