title: Dietary intake of rapeseed oil as the sole fat nutrient in Wistar rats--lack of increase in plasma lipids and renal lesions.
abstract: Dietary rapeseed (canola) oil (CO) given as the only fat nutrient shortens life in stroke-prone spontaneously hypertensive rats (SHRSP), compared with SHRSP given soybean oil (SO) instead of CO. CO ingestion increases plasma lipids and causes renal lesions in SHRSP and in spontaneously hypertensive rats (SHR), and increases plasma lipids also in Wistar Kyoto (WKY) rats, a normotensive counterpart of SHR. This study examined whether or not such unfavorable effects of CO are restricted to these closely related strains. For this purpose Wistar rats, the strain from which these strains were derived, were fed a diet containing 10% CO or SO as the sole fat nutrient for 10 weeks, and changes in clinical signs, urinalysis, blood biochemistry and pathology were compared. CO ingestion did not induce any abnormalities in Wistar rats, except significant increases in plasma concentrations of aldosterone and Na(+), compared with the SO group. Thus, the unfavorable effects of CO ingestion appear to be restricted to SHRSP and its closely related strains. The role of increased aldosterone and Na(+ )in the unfavorable events caused by CO in SHRSP, SHR and WKY rats, and any factors which could induce such increases in aldosterone and Na(+), remain to be elucidated.
authors.forename: Naoki
authors.initials: N
authors.lastname: Ohara
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Naito
authors.forename: Tomoko
authors.initials: T
authors.lastname: Nagata
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Tachibana
authors.forename: Mari
authors.initials: M
authors.lastname: Okimoto
authors.forename: Harumi
authors.initials: H
authors.lastname: Okuyama
mesh_terms: D000450:Aldosterone / Q000097:blood; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004041:Dietary Fats / Q000008:administration & dosage / Q000009:adverse effects; D004435:Eating / Q000187:drug effects; D005229:Fatty Acids, Monounsaturated; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D008055:Lipids / Q000097:blood*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D009928:Organ Specificity; D010938:Plant Oils / Q000008:administration & dosage / Q000009:adverse effects; D000074262:Rapeseed Oil; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000097:blood; D013024:Soybean Oil / Q000008:administration & dosage / Q000009:adverse effects; D013045:Species Specificity; D016482:Urinalysis
chemical_list: D004041:Dietary Fats; D005229:Fatty Acids, Monounsaturated; D008055:Lipids; D010938:Plant Oils; D000074262:Rapeseed Oil; D000450:Aldosterone; D013024:Soybean Oil; D012964:Sodium