Peroxisome proliferator-activated receptor alpha and the ketogenic diet.
Peroxisome proliferator-activated receptor alpha (PPARalpha) is a drug/fatty acid-activated trans cription factor involved in the starvation response, and is thus relevant to the ketogenic diet (KD). This article summarizes research indicating the role of PPARalpha in central and peripheral nervous system function with particular reference to downstream targets relevant to anticonvulsant action.
Cullingford
Tim
T
National Heart and Lung Institute Division, Faculty of Medicine, Imperial College, London, United Kingdom. t.cullingford@imperial.ac.uk
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D055423:Diet, Ketogenic; D004827:Epilepsy / Q000178:diet therapy*; D006801:Humans; D047493:PPAR alpha / Q000378:metabolism*
D000927:Anticonvulsants; D047493:PPAR alpha