title: Anti-asthmatic effect of marine red alga (Laurencia undulata) polyphenolic extracts in a murine model of asthma.
abstract: The aim of the present work is focused on protective effects of an edible red alga, Laurencia undulata ethanolic (EtOH) extracts (LU) containing a large amount of polyphenols against OVA-induced murine allergic airway reactions using in vivo histological and cytokine assay. Mice sensitized and challenged with ovalbumin (OVA) showed typical asthmatic reactions as follows: an increase in the number of eosinophil in bronchoalveolar lavage fluid; a marked influx of inflammatory cells into the lung around blood vessels and airways, and airway luminal narrowing; the development of airway hyperresponsiveness; the detection of TNF-alpha and Th2 cytokines, such as IL-4 and IL-5 in the bronchoalveolar lavage (BAL) fluid; and detection of allergen-specific IgE in the serum. The successive intraperitoneal administration of LU before the last airway OVA-challenge resulted in a significant inhibition of all asthmatic reactions. These results suggest that L. undulata polyphenolic extracts possess therapeutic potential for combating bronchial asthma associated with allergic diseases.
authors.affiliation: Department of Marine Life Science and Marine Life Research Center, Chosun University, Gwangju 501-759, Republic of Korea.
authors.forename: Won-Kyo
authors.initials: WK
authors.lastname: Jung
authors.forename: Inhak
authors.initials: I
authors.lastname: Choi
authors.forename: Sangtaek
authors.initials: S
authors.lastname: Oh
authors.forename: Sae-Gwang
authors.initials: SG
authors.lastname: Park
authors.forename: Su-Kil
authors.initials: SK
authors.lastname: Seo
authors.forename: Soo-Woong
authors.initials: SW
authors.lastname: Lee
authors.forename: Dae-Sung
authors.initials: DS
authors.lastname: Lee
authors.forename: Soo-Jin
authors.initials: SJ
authors.lastname: Heo
authors.forename: You-Jin
authors.initials: YJ
authors.lastname: Jeon
authors.forename: Jae-Young
authors.initials: JY
authors.lastname: Je
authors.forename: Chang-Bum
authors.initials: CB
authors.lastname: Ahn
authors.forename: Jin Soo
authors.initials: JS
authors.lastname: Kim
authors.forename: Kwang Soo
authors.initials: KS
authors.lastname: Oh
authors.forename: Young-Mog
authors.initials: YM
authors.lastname: Kim
authors.forename: Chisook
authors.initials: C
authors.lastname: Moon
authors.forename: Il-Whan
authors.initials: IW
authors.lastname: Choi
mesh_terms: D000818:Animals; D018927:Anti-Asthmatic Agents / Q000494:pharmacology*; D001249:Asthma / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000166:cytology; D016207:Cytokines / Q000032:analysis / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D044722:Laurencia / Q000737:chemistry*; D008168:Lung / Q000187:drug effects / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D010047:Ovalbumin / Q000276:immunology; D010636:Phenols / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology; D059808:Polyphenols
chemical_list: D018927:Anti-Asthmatic Agents; D016207:Cytokines; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols; D010047:Ovalbumin