title: Expression of common familial dyslipidemias in early childhood.
abstract: Early identification of common familial dyslipidemias may prevent premature atherosclerotic disease. This study estimated the diagnostic values of few early childhood repeatedly deviant lipid samples by the knowledge of the parent's dyslipidemia. The first 7 years of age data of 353 children with their parents were evaluated from atherosclerosis risk-factor intervention study controls. Parents' low high-density-lipoprotein-cholesterol concentration (hypo-HDL-C), and high total cholesterol concentration-HDL-C (hyper-non-HDL-C) were defined. True hypo-HDL-C and hyper-non-HDL-C children were defined when their respective individual longitudinal means were beyond the appropriate lipid quintiles. Sensitivities, specificities, positive and negative predictive values of the early lipid samples were estimated with individual standard deviation models and bootstrap confidence. Hypo-HDL-C children proportions were 15.3% of all, and 20.9% of the children from the hypo-HDL-C parents (p=0.26). Hyper-non-HDL-C children were 16.7% of all and 31.8% of the children from the hyper-non-HDL-C parents (p=0.008). One early non-HDL-C sample in the highest quintile predicted 56% of the hyper-non-HDL-C children from healthy parents, but 83% of the hyper-non-HDL-C children from the hyper-non-HDL-C parents. Mean of three samples improved the latter prediction to 91%. This showed that if hypercholesterolemic parent's child expressed repeatedly hyper-non-HDL-C, it predicts true dyslipidemia of the child.
authors.affiliation: Department of Medicine, University of Turku, Turku, Finland. Jouni.Lapinleimu@tyks.fi
authors.forename: J
authors.initials: J
authors.lastname: Lapinleimu
authors.forename: H
authors.initials: H
authors.lastname: Lapinleimu
authors.forename: I O
authors.initials: IO
authors.lastname: Nuotio
authors.forename: T
authors.initials: T
authors.lastname: Rönnemaa
authors.forename: O G
authors.initials: OG
authors.lastname: Simell
authors.forename: J S A
authors.initials: JS
authors.lastname: Viikari
mesh_terms: D017668:Age of Onset; D050197:Atherosclerosis / Q000097:blood / Q000235:genetics / Q000517:prevention & control*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D042241:Early Diagnosis; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D007223:Infant; D010375:Pedigree; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D013997:Time Factors
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL