title: Palivizumab use among children with congenital heart disease in Quebec: Impact of Canadian guidelines on clinical practice.
abstract: BACKGROUND
  Palivizumab has been shown to reduce the risk of hospitalization caused by respiratory syncytial virus in children with congenital heart disease (CHD). Guidelines published in 2003 by the Canadian Paediatric Society (CPS) stated that children younger than 24 months with hemodynamically significant CHD should be considered for up to five monthly doses of palivizumab during the winter season.
  
  
  OBJECTIVE
  To assess the impact of CPS guidelines on the use of palivizumab in children with CHD.
  
  
  METHODS
  Clinical information was reviewed on all patients with CHD who were prescribed palivizumab in 2002-2003 and 2003-2004 and who were followed by one of four paediatric cardiovascular programs in the province of Quebec.
  
  
  RESULTS
  Palivizumab was prescribed to 45 children in 2002-2003 and to 146 children in 2003-2004. The number of children receiving more than five doses increased from 10 of 45 (22%) in 2002-2003 to 57 of 128 (45%) in 2003-2004 (P=0.008). One hundred seventeen of 146 children (80%) receiving palivizumab in 2003-2004 met the CPS guidelines versus 38 of 45 children (84%) in 2002-2003 (ie, before the guidelines were published) (P=0.66). Patients not meeting CPS criteria were older than 24 months at the time of the first dose, had hemodynamically insignificant CHD or had lesions adequately corrected by surgery.
  
  
  CONCLUSIONS
  The number of children with CHD receiving palivizumab prophylaxis increased significantly following the publication of CPS guidelines. The majority of children were eligible for palivizumab according to the current CPS criteria. More patients received more than five doses in 2003-2004 than in 2002-2003.
authors.affiliation: Division of Cardiology, Montreal Children's Hospital, McGill University Health Centre, Montreal.
authors.forename: Marc
authors.initials: M
authors.lastname: Bellavance
authors.forename: Charles V
authors.initials: CV
authors.lastname: Rohlicek
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Bigras
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Côté
authors.forename: Marc
authors.initials: M
authors.lastname: Paquet
authors.forename: Marc H
authors.initials: MH
authors.lastname: Lebel
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Mackie