title: Role of type II NKT cells in the suppression of graft-versus-host disease.
abstract: Natural killer T (NKT) cells, a distinct subset of T cells that recognize glycolipids on CD1d molecules, express both TCR and NK receptors and are critical in regulating various immune responses by modulating the Th1/Th2 balance. Upon activation, NKT cells produce large amounts of IL-4 and IFN-gamma, resulting in the enhancement or inhibition of immune responses. Recent studies have shown that NKT cells are heterogeneous in terms of the expression of a specific Valpha chain of TCR (Valpha14-Jalpha18 in mice and Valpha24-JalphaQ in humans) and reactivity against the glycolipid alpha-galactosylceramide (alpha-GalCer). Accordingly, NKT cells are classified into type I (invariant) and type II (non-invariant) cells in mice and humans. Although the functional roles of type I NKT cells are well characterized in various immune diseases, little is known regarding the function of type II NKT cells. Recent study has demonstrated that type II NKT cells in donor bone marrow play protective roles in graft-versus-host disease (GVHD), in which the complicated immunologic processes are involved. In this review, we discuss the pathogenesis of GVHD and the distinct functions of type II NKT cells in the development of GVHD.
authors.affiliation: Department of Pathology, Seoul National University College of Medicine, Chongno-gu, 110-799, Seoul, South Korea.
authors.forename: Sae Jin
authors.initials: SJ
authors.lastname: Oh
authors.forename: Ji Hyung
authors.initials: JH
authors.lastname: Kim
authors.forename: Chang Ki
authors.initials: CK
authors.lastname: Min
authors.forename: Doo Hyun
authors.initials: DH
authors.lastname: Chung
mesh_terms: D000818:Animals; D016026:Bone Marrow Transplantation / Q000276:immunology; D016207:Cytokines / Q000276:immunology* / Q000378:metabolism; D006028:Glycosphingolipids / Q000276:immunology / Q000378:metabolism; D006086:Graft vs Host Disease / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D055611:Natural Killer T-Cells / Q000276:immunology* / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
chemical_list: D016207:Cytokines; D006028:Glycosphingolipids