title: Biosynthetic evidence supporting the generation of terpene chemodiversity in marine mollusks of the genus Doriopsilla.
abstract: This paper reports the study of terpene biosynthesis in the marine nudibranch Doriopsilla pelseneeri. In vivo feeding experiments with 13C-glucose proved the de novo origin of the terpene metabolites via a mevalonate pathway. Characterization of the stereochemical relationship of the new acetyl pelseneeriols (7 and 8) suggests a two-step mechanism for the sesquiterpene cyclization, leading to a slight refinement of terpene tailoring in this family of marine invertebrates.
authors.affiliation: Instituto Nacional de Engenharia, Tecnologia e Inovacao (INETI), Estrada do Paco do Lumiar, Edificio F, 1649-038 Lisboa, Portugal.
authors.forename: Helena
authors.initials: H
authors.lastname: Gaspar
authors.forename: Adele
authors.initials: A
authors.lastname: Cutignano
authors.forename: Teodora
authors.initials: T
authors.lastname: Ferreira
authors.forename: Gonçalo
authors.initials: G
authors.lastname: Calado
authors.forename: Guido
authors.initials: G
authors.lastname: Cimino
authors.forename: Angelo
authors.initials: A
authors.lastname: Fontana
mesh_terms: D000818:Animals; D008386:Marine Biology; D008798:Mevalonic Acid / Q000378:metabolism; D015394:Molecular Structure; D008974:Mollusca / Q000737:chemistry*; D009792:Oceans and Seas; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D012717:Sesquiterpenes; D013729:Terpenes; C534629:acetylpelseneeriol-1; C534630:acetylpelseneeriol-2; D008798:Mevalonic Acid