title: Immunohistochemical expression of MMP-2, MMP-9 and COX-2 in Stage IA malignant polyps of the endometrium.
abstract: OBJECTIVE
  To study whether endometrioid type malignant endometrial polyps (MEP) are different from endometrium cancer not associated with polyps (ECNAP) in means of immunohistochemical expressions of MMP-2, MMP-9 and COX-2.
  
  
  METHODS
  Archived tissue samples of eight MEP, eight ECNAP and 16 benign endometrial polyps were selected and immunohistochemically analyzed for MMP-2, MMP-9 and COX-2 expression.
  
  
  RESULTS
  MMP-2 and MMP-9 were overexpressed in ECNAP compared to MEP and benign endometrial polyps (p < 0.05). MMP-2 and MMP-9 expressions were not different in the malignant part of MEP, benign part of MEP and benign endometrial polyps. COX-2 expression was found to be higher in benign lesions, although this was not statistically significant.
  
  
  CONCLUSIONS
  Similar immunohistochemical expression of MMP-2, MMP-9 and COX-2 within a polyp and with benign polyps may indicate an immunohistochemically indolent characteristic of MEP.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, University of Süleyman Demirel, Isparta, Turkey. evrimmd@yahoo.com
authors.forename: E
authors.initials: E
authors.lastname: Erdemoglu
authors.forename: M
authors.initials: M
authors.lastname: Güney
authors.forename: N
authors.initials: N
authors.lastname: Karahan
authors.forename: T
authors.initials: T
authors.lastname: Mungan
mesh_terms: D051546:Cyclooxygenase 2 / Q000032:analysis*; D016889:Endometrial Neoplasms / Q000737:chemistry*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D020778:Matrix Metalloproteinase 2 / Q000032:analysis*; D020780:Matrix Metalloproteinase 9 / Q000032:analysis*; D011127:Polyps / Q000737:chemistry*
chemical_list: D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9