title: Host genetic susceptibility to pneumococcal and meningococcal disease: a systematic review and meta-analysis.
abstract: Streptococcus pneumoniae and Neisseria meningitidis can cause sepsis and meningitis. Several risk factors for pneumococcal and meningococcal disease have been identified, but the cause of basic differences in susceptibility between individuals and populations is unknown. Single-nucleotide polymorphisms are thought to explain interindividual differences in susceptibility. New technologies provide the opportunity to study the genetic basis of susceptibility to these diseases. In recent years, several studies have been published on these polymorphisms in pneumococcal and meningococcal disease, many with apparently conflicting results. Herein we provide a systematic overview of all polymorphisms studied for a relation with susceptibility to pneumococcal and meningococcal disease. We also propose an initiative to pool genetic data on pneumococcal and meningococcal meningitis in one biobank.
authors.affiliation: Department of Neurology, Centre for Infection and Immunity Amsterdam (CINIMA), Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands.
authors.forename: Matthijs C
authors.initials: MC
authors.lastname: Brouwer
authors.forename: Jan
authors.initials: J
authors.lastname: de Gans
authors.forename: Sebastiaan G B
authors.initials: SG
authors.lastname: Heckenberg
authors.forename: Aeilko H
authors.initials: AH
authors.lastname: Zwinderman
authors.forename: Tom
authors.initials: T
authors.lastname: van der Poll
authors.forename: Diederik
authors.initials: D
authors.lastname: van de Beek
mesh_terms: D020022:Genetic Predisposition to Disease; D006801:Humans; D008589:Meningococcal Infections / Q000235:genetics* / Q000276:immunology / Q000382:microbiology; D011008:Pneumococcal Infections / Q000235:genetics* / Q000276:immunology / Q000382:microbiology; D011110:Polymorphism, Genetic