Electroacupuncture promotes insulin-like growth factors system in ovariectomized osteoporosis rats.
Postmenopausal Osteoporosis (PMOP) is induced by the deficiency of estrogen in postmenopausal women. Electroacupuncture (EA) has been confirmed to be effective in clinic. We adopted ovariectomized osteoporosis model of rats to observe the role of EA in PMOP. Fifty female SD rats were divided randomly into 5 groups: intact (INT, n = 10), sham operation (Sham, n = 10), model (n = 10), estrogen (E, n = 10) and electroacupuncture (EA, n = 10). The bone mineral content (BMC) and the bone mineral density (BMD) were examined in lumbar(1-6) and right thigh-bone, respectively, and estrodiol (E(2)), insulin-like growth factor I (IGF-I) and insulin-like growth factor binding proteins (IGF-BPs) were tested by RIA or ELISA. The results showed that BMC and BMD of lumbar 1-6 and right thigh-bone in PMOP model rats decreased markedly, while the level of serum E(2), IGF-I and IGF-BP1 were lower than in INT and Sham. However, EA could upgrade the contents of IGF-I and IGF-BP1 to increase BMD in PMOP rats, while no significant difference was seen in E group. Therefore, EA may promote IGF system to improve PMOP.
Feng
Yi
Y
Department of Neurobiology and Integrative Medicine, Institution of Acupuncture Research, Shanghai Medical College of Fudan University, 138 Yi-Xue-Yuan Road, Shanghai, China.
Lin
Huagang
H
Zhang
Ying
Y
Li
Lierong
L
Wu
Xuping
X
Wang
Tienpei
T
Liu
Youxiang
Y
Tan
Yilun
Y
D000818:Animals; D015519:Bone Density; D015671:Electroacupuncture; D005260:Female; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000032:analysis* / Q000378:metabolism; D015663:Osteoporosis, Postmenopausal / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D010052:Ovariectomy; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D018969:Insulin-Like Growth Factor Binding Proteins; D007334:Insulin-Like Growth Factor I