Fudosteine effects on mucin production.
BACKGROUND
Many chronic respiratory conditions are associated with mucin hypersecretion induced by underlying inflammation.


OBJECTIVE
To analyse the results of a preclinical study assessing the pathogenic mechanisms of mucin hyperproduction and the consequent in vivo and in vitro effects of fudosteine, a mucoactive agent.


RESULTS
Both LPS and TNF-alpha increased MUC5AC mucin production in vivo and in vitro, respectively, and fudosteine was found to reduce it by partially interfering with the kinase-mediated inflammation pathway that activates the MUC5AC gene.


CONCLUSIONS
Further preclinical testing in animal models with chronic airways inflammation is necessary.
Antonela Antoniu
Sabina
S
University of Medicine and Pharmacy Gr T Popa Iasi, Division of Pulmonary Disease, Pulmonary Disease University Hospital, Iasi, RO 700115, Romania. sabina.antonela.antoniu@pneum.umfiasi.ro