Recombinant canine coronaviruses related to transmissible gastroenteritis virus of Swine are circulating in dogs.
Four canine coronavirus type II (CCoV-II) strains were identified in the guts and internal organs of pups which had died of acute gastroenteritis. The CCoV-II strains were strictly related to porcine transmissible gastroenteritis virus (TGEV) in the N-terminal domain of the spike protein, whereas in the other parts of the genome, a higher genetic relatedness to recent CCoV-II isolates was observed. Experimental infection of dogs with a TGEV-like isolate induced mild gastroenteritis without any systemic involvement. By virus neutralization tests, antigenic differences between reference and TGEV-like CCoVs were found. Our data support the potential recombinant origin of the TGEV-like CCoVs.
Decaro
Nicola
N
Department of Public Health and Animal Sciences, Faculty of Veterinary Medicine, Valenzano (Bari), Italy. n.decaro@veterinaria.uniba.it
Mari
Viviana
V
Campolo
Marco
M
Lorusso
Alessio
A
Camero
Michele
M
Elia
Gabriella
G
Martella
Vito
V
Cordioli
Paolo
P
Enjuanes
Luis
L
Buonavoglia
Canio
C
D000818:Animals; D001483:Base Sequence; D017934:Coronavirus / Q000145:classification / Q000235:genetics / Q000502:physiology*; D004279:DNA, Viral; D004283:Dog Diseases / Q000821:virology*; D004285:Dogs; D005761:Gastroenteritis, Transmissible, of Swine / Q000635:transmission* / Q000821:virology; D008969:Molecular Sequence Data; D010802:Phylogeny; D011995:Recombination, Genetic; D012689:Sequence Homology, Nucleic Acid
D004279:DNA, Viral