Nanoarchaeal origin of histone H3?
NEQ288, one of two archaeal histones in Nanoarchaeum equitans, has a unique four-residue insertion that closely resembles an insertion in the eukaryotic histone H3 lineage. NEQ288 bound DNA but did not compact DNA in vitro in the absence of NEQ348, the second N. equitans archaeal histone. The properties of NEQ288 suggest an intermediate between the archaeal and H3 histone lineages and an evolutionary step toward the now-mandatory assembly of eukaryotic histones into heterodimers.
Friedrich-Jahn
Ulrike
U
Institute for Microbiology and Archaeal Center, University of Regensburg, D-93053 Regensburg, Germany.
Aigner
Johanna
J
Längst
Gernot
G
Reeve
John N
JN
Huber
Harald
H
D000595:Amino Acid Sequence; D019843:Archaeal Proteins / Q000737:chemistry / Q000235:genetics*; D019641:DNA, Archaeal / Q000235:genetics; D019143:Evolution, Molecular; D019848:Gene Expression Regulation, Archaeal; D006657:Histones / Q000737:chemistry / Q000235:genetics*; D008969:Molecular Sequence Data; D046588:Nanoarchaeota / Q000235:genetics* / Q000378:metabolism; D017433:Protein Structure, Secondary; D017386:Sequence Homology, Amino Acid
D019843:Archaeal Proteins; D019641:DNA, Archaeal; D006657:Histones