[The present situation and future prospects of bone substitute of bioinspired materials].
As for an artificial bone which is a substitute material of a bone which supports our body, a block/a granulation or paste properties are manufactured by HAP or beta-TCP. They are similar ingredient of the bone itself. In particular, beta-TCP shows excellent absorbency, and it is applied as a scaffold of tissue engineering of a bony structure. Because such an artificial bone does not obstruct bone metabolism such as the absorption by osteoblasts and bone formation by osteoblasts, such product has both interconnected pore and bioabsorbable properties. However, these artificial bones alone cannot meet demands of clinical practice side. Therefore it is necessary to have the material designs that can promote the work of three factors of cell/Growth factor/Scaffold to future artificial bones, a function more suitable for operation applications. And I would hope that the level of regenerative medicine would drastically improve by further development above mentioned artificial bone.
Inoue
Hikaru
H
Olympus Terumo Biomaterials Corporation.
D000042:Absorption; D001672:Biocompatible Materials; D018786:Bone Substitutes; D001842:Bone and Bones; D002130:Calcium Phosphates; D002356:Cartilage; D017886:Durapatite; D006801:Humans; D010006:Osteoblasts; D010012:Osteogenesis; D023822:Tissue Engineering; D054457:Tissue Scaffolds
D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate; D017886:Durapatite