A frequency-adjustable electromagnet for hyperthermia measurements on magnetic nanoparticles.
We describe a low-cost and simple setup for hyperthermia measurements on colloidal solutions of magnetic nanoparticles (ferrofluids) with a frequency-adjustable magnetic field in the range of 5-500 kHz produced by an electromagnet. By optimizing the general conception and each component (nature of the wires, design of the electromagnet, etc.), a highly efficient setup is obtained. For instance, in a useful gap of 1.1 cm, a magnetic field of 4.8 mT is generated at 100 and 500 kHz with output powers of 3.4 and 75 W, respectively. A maximum magnetic field of 30 mT is obtained at 100 kHz. The temperature of the colloidal solution is measured using optical fiber sensors. To remove contributions due to heating of the electromagnet, a differential measurement is used. In this configuration the sensitivity is better than 1.5 mW at 100 kHz and 19.3 mT. This setup allows one to measure weak heating powers on highly diluted colloidal solutions. The hyperthermia characteristics of a solution of Fe nanoparticles are described, where both the magnetic field and the frequency dependence of heating power have been measured.
Lacroix
L-M
LM
Université de Toulouse-INSA-UPS-LPCNO, 135 Avenue de Rangueil, F-31077 Toulouse, France.
Carrey
J
J
Respaud
M
M
D003102:Colloids; D017097:Electric Impedance; D004574:Electromagnetic Fields; D004867:Equipment Design / Q000295:instrumentation*; D005290:Ferric Compounds / Q000737:chemistry; D006979:Hyperthermia, Induced / Q000295:instrumentation / Q000379:methods*; D008280:Magnetics; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009532:Nickel / Q000737:chemistry; D055100:Optical Fibers; D010316:Particle Size; D012996:Solutions / Q000737:chemistry
D003102:Colloids; D005290:Ferric Compounds; D012996:Solutions; D009532:Nickel