Evaluation of aspirin metabolites as inhibitors of hypoxia-inducible factor hydroxylases.
Known and potential aspirin metabolites were evaluated as inhibitors of oxygen-sensing hypoxia-inducible transcription factor (HIF) hydroxylases; some of the metabolites were found to stabilise HIF-alpha in cells.
Lienard
Benoit M
BM
The Department of Chemistry and the Oxford Centre for Integrative Systems Biology, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, United Kingdom.
Conejo-García
Ana
A
Stolze
Ineke
I
Loenarz
Christoph
C
Oldham
Neil J
NJ
Ratcliffe
Peter J
PJ
Schofield
Christopher J
CJ
D001241:Aspirin / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D049308:Dioxygenases / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D015394:Molecular Structure; D021241:Spectrometry, Mass, Electrospray Ionization
D004791:Enzyme Inhibitors; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D049308:Dioxygenases; D001241:Aspirin