title: New diffusion phantoms dedicated to the study and validation of high-angular-resolution diffusion imaging (HARDI) models.
abstract: We present new diffusion phantoms dedicated to the study and validation of high-angular-resolution diffusion imaging (HARDI) models. The phantom design permits the application of imaging parameters that are typically employed in studies of the human brain. The phantoms were made of small-diameter acrylic fibers, chosen for their high hydrophobicity and flexibility that ensured good control of the phantom geometry. The polyurethane medium was filled under vacuum with an aqueous solution that was previously degassed, doped with gadolinium-tetraazacyclododecanetetraacetic acid (Gd-DOTA), and treated by ultrasonic waves. Two versions of such phantoms were manufactured and tested. The phantom's applicability was demonstrated on an analytical Q-ball model. Numerical simulations were performed to assess the accuracy of the phantom. The phantom data will be made accessible to the community with the objective of analyzing various HARDI models.
authors.affiliation: NeuroSpin, Commissariat à l'Energie Atomique, Institut d'Imagerie Bio-Médicale, Gif-sur-Yvette, France. cyril.poupon@cea.fr
authors.forename: Cyril
authors.initials: C
authors.lastname: Poupon
authors.forename: Bernard
authors.initials: B
authors.lastname: Rieul
authors.forename: Irina
authors.initials: I
authors.lastname: Kezele
authors.forename: Muriel
authors.initials: M
authors.lastname: Perrin
authors.forename: Fabrice
authors.initials: F
authors.lastname: Poupon
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Mangin
mesh_terms: D000465:Algorithms; D038524:Diffusion Magnetic Resonance Imaging / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity