title: Furanocembranoids from the soft corals Sinularia asterolobata and Litophyton arboreum.
abstract: The new cembranoid diterpene danielid (1) along with 3alpha-ethoxyfuranocembranoid 2, pukalide (3), 13alpha-acetoxypukalide (4), furanocembranoid 5, and furanosesquiterpene 6 have been isolated from the soft coral Sinularia asterolobata. The furanocembranoid diterpene 11beta,12beta-epoxypukalide (7) and the sesquiterpene (-)-bicyclogermacrene (8) have been obtained from the soft coral Litophyton arboreum. The structures were elucidated primarily by NMR spectroscopy. The furanocembranoids 2, 4, and 5 show good antiproliferative activities against the cell lines L-929 and K-562, and weak cytotoxic effects on HeLa cells.
authors.affiliation: Lehrstuhl für Organische Chemie, NW II, Universität Bayreuth, D-95440 Bayreuth.
authors.forename: Daniela
authors.initials: D
authors.lastname: Grote
authors.forename: Hans-Martin
authors.initials: HM
authors.lastname: Dahse
authors.forename: Karlheinz
authors.initials: K
authors.lastname: Seifert
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D006131:Growth Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D006801:Humans; D007928:Lethal Dose 50; D051379:Mice; D014407:Tumor Cells, Cultured
chemical_list: D004224:Diterpenes; D006131:Growth Inhibitors