title: Gliosarcoma: an audit from a single institution in India of 24 post-irradiated cases over 15 years.
abstract: BACKGROUND
  Gliosarcomas (GS) are biphasic brain tumors composed of glioblastoma multiforme (GBM) and sarcomatous component. Therapeutic approaches include maximum surgical decompression with postoperative radiotherapy. Outcomes in gliosarcoma are poor despite multimodality management.
  
  
  OBJECTIVE
  To analyze the outcome in patients of GS treated in our institute over a period of 15 years and compare it with GBM treated during the same period.
  
  
  METHODS
  Clinical records of the post-irradiated GS patients and GBM patients seen between 1990 and 2004 were retrieved.
  
  
  METHODS
  Demographic and treatment variables were evaluated for their influence on overall survival (OS). The survival outcomes of GBM and GS treated during the same period were also compared.
  
  
  METHODS
  Univariate analysis was carried out using the Kaplan-Meier method and tested using log-rank test for significance.
  
  
  RESULTS
  During these 15 years, 24 evaluable GS patients were treated as compared to 251 evaluable patients of GBM. There was a slight male preponderance in GS (14 males vs.10 females) with a median age of 50 years. All patients underwent surgery followed by post-operative radiotherapy (median dose of 60 Gy). None of the patient or treatment related factors were found to be significantly influencing their OS. Median OS in GS was 7.3 months compared to 7.5 months in GBM patients (P = 0.790).
  
  
  CONCLUSIONS
  The OS appears to be similar for GS and GBM. None of the demographic variables appeared to prognosticate the survivals of GS.
authors.affiliation: Department of Radiotherapy, Regional Cancer Centre, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, U.P, India.
authors.forename: Piyush
authors.initials: P
authors.lastname: Kumar
authors.forename: Shalini
authors.initials: S
authors.lastname: Singh
authors.forename: Pavan
authors.initials: P
authors.lastname: Kumar
authors.forename: Narendra
authors.initials: N
authors.lastname: Krishnani
authors.forename: Niloy R
authors.initials: NR
authors.lastname: Datta
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000532:radiotherapy*; D002986:Clinical Trials as Topic; D005260:Female; D005909:Glioblastoma / Q000532:radiotherapy*; D018316:Gliosarcoma / Q000532:radiotherapy*; D006801:Humans; D007194:India; D008297:Male; D008495:Medical Oncology / Q000379:methods; D008875:Middle Aged; D015233:Models, Statistical; D016896:Treatment Outcome