title: siRNA conjugate delivery systems.
abstract: Small interfering RNA (siRNA) has been chemically conjugated to a variety of bioactive molecules, lipids, polymers, peptides, and inorganic nanostructured materials to enhance their pharmacokinetic behavior, cellular uptake, target specificity, and safety. To efficiently deliver siRNAs to the target cells and tissues, many different siRNA bioconjugates were synthesized and characterized, and their gene silencing efficiencies were tested in vitro and in vivo. In this review, recent developments of siRNA bioconjugates are summarized.
authors.affiliation: College of Pharmacy, Sungkyunkwan University, Suwon 440-746, South Korea, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, South Korea.
authors.forename: Ji Hoon
authors.initials: JH
authors.lastname: Jeong
authors.forename: Hyejung
authors.initials: H
authors.lastname: Mok
authors.forename: Yu-Kyoung
authors.initials: YK
authors.lastname: Oh
authors.forename: Tae Gwan
authors.initials: TG
authors.lastname: Park
mesh_terms: D016503:Drug Delivery Systems / Q000379:methods*; D020868:Gene Silencing; D006801:Humans; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D034741:RNA, Small Interfering