Asymmetric Friedel-Crafts alkylations of indoles with dialkyl 3-oxoprop-1-enylphosphonates: organocatalytic enantioselective synthesis of alpha-indolyl phosphonates.
Organocatalytic enantioselective synthesis of alpha-indolyl phosphonates has been successfully carried out via asymmetric Friedel-Crafts alkylation of substituted indoles with (E)-dialkyl 3-oxoprop-1-enylphosphonates in 48-82% yield and 73-96% ee.
Guo
Ying-Cen
YC
Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, Hubei 430079, China.
Li
Dong-Ping
DP
Li
Yu-Ling
YL
Wang
Hong-Mei
HM
Xiao
Wen-Jing
WJ
D000478:Alkylation; D002384:Catalysis; D002625:Chemistry, Organic; D007211:Indoles / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D063065:Organophosphonates / Q000737:chemistry*; D013237:Stereoisomerism
D007211:Indoles; D063065:Organophosphonates