title: Bupivacaine cardiotoxicity--hypercarbia is bad but hypocapnia may be worse.
authors.forename: Derek
authors.initials: D
authors.lastname: Dillane
authors.forename: Brendan T
authors.initials: BT
authors.lastname: Finucane
mesh_terms: D000577:Amides / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D000765:Anesthesia, Conduction / Q000009:adverse effects; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D000818:Animals; D002045:Bupivacaine / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D002245:Carbon Dioxide / Q000378:metabolism; D054715:Cardiotoxins / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D005217:Fat Emulsions, Intravenous; D006323:Heart Arrest / Q000139:chemically induced / Q000628:therapy; D006801:Humans; D006935:Hypercapnia / Q000139:chemically induced* / Q000628:therapy; D016857:Hypocapnia / Q000139:chemically induced* / Q000628:therapy; D000077554:Levobupivacaine; D010818:Practice Patterns, Physicians'; D012151:Resuscitation; D000077212:Ropivacaine
chemical_list: D000577:Amides; D000779:Anesthetics, Local; D054715:Cardiotoxins; D005217:Fat Emulsions, Intravenous; D002245:Carbon Dioxide; D000077212:Ropivacaine; D000077554:Levobupivacaine; D002045:Bupivacaine