title: Survivin expression in renal cell carcinoma.
abstract: Deregulated expression of inhibitors of apoptosis may contribute to cancer by aberrantly extending cell viability and facilitating the insurgence of resistance to chemo- and radiotherapy. In this study, we have investigated, by immunohistochemical technique, the expression and potential prognostic significance of survivin in a series of 49 clear cell type renal cell carcinoma (ccRCC). Survivin expression was significantly associated with poorly differentiated, advanced stages and more aggressive ccRCCs (p < 0.05). Patients with low survivin expression had statistically significant better survival rates than patients with high survivin expression (p < 0.05). This may be relevant for follow-up protocols design and/or alternative therapeutic approaches.
authors.affiliation: Department of Surgical Sciences, University of Foggia, Foggia, Italy.
authors.forename: Rosanna
authors.initials: R
authors.lastname: Zamparese
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Pannone
authors.forename: Angela
authors.initials: A
authors.lastname: Santoro
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Lo Muzio
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Corsi
authors.forename: Maria C
authors.initials: MC
authors.lastname: Pedicillo
authors.forename: Ester L
authors.initials: EL
authors.lastname: Scillitani
authors.forename: Simona
authors.initials: S
authors.lastname: Tortorella
authors.forename: Stefania
authors.initials: S
authors.lastname: Staibano
authors.forename: Salvatore
authors.initials: S
authors.lastname: Piscuoglio
authors.forename: Lucio
authors.initials: L
authors.lastname: Lo Russo
authors.forename: Pantaleo
authors.initials: P
authors.lastname: Bufo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D002292:Carcinoma, Renal Cell / Q000378:metabolism / Q000401:mortality* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D007680:Kidney Neoplasms / Q000378:metabolism / Q000401:mortality* / Q000473:pathology; D008297:Male; D008869:Microtubule-Associated Proteins / Q000096:biosynthesis*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D016019:Survival Analysis; D000077022:Survivin
chemical_list: C107489:BIRC5 protein, human; D014408:Biomarkers, Tumor; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D000077022:Survivin