title: Ultrastructural effects of oritavancin on methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus.
abstract: The ultrastructural effects of the lipoglycopeptide oritavancin on methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococcus (VRE) were examined by transmission electron microscopy. Oritavancin but not vancomycin induced aberrant septum formation and loss of staining of nascent septal cross walls in MRSA. Septal distortions were also observed in VRE exposed to oritavancin.
authors.affiliation: Targanta Therapeutics Inc., St. Laurent, Quebec, Canada.
authors.forename: Adam
authors.initials: A
authors.lastname: Belley
authors.forename: Robert
authors.initials: R
authors.lastname: Harris
authors.forename: Terry
authors.initials: T
authors.lastname: Beveridge
authors.forename: Tom
authors.initials: T
authors.lastname: Parr
authors.forename: Gregory
authors.initials: G
authors.lastname: Moeck
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D015169:Colony Count, Microbial; D020285:Cryoelectron Microscopy; D016983:Enterococcus / Q000187:drug effects* / Q000648:ultrastructure*; D006020:Glycopeptides / Q000494:pharmacology*; D000077427:Lipoglycopeptides; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000648:ultrastructure*; D014640:Vancomycin / Q000494:pharmacology / Q000031:analogs & derivatives; D020713:Vancomycin Resistance / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D006020:Glycopeptides; D000077427:Lipoglycopeptides; C079913:VanB protein, Enterococcus; D014640:Vancomycin; C100708:oritavancin