title: [Granulocyte-colony stimulating factor producing tumor with high serum interleukin-6].
abstract: A 53-year-old man admitted to our hospital because of fever and chest abnormal shadow. Chest X-ray and computed tomography (CT) scan revealed large tumor on right upper lobe. Serum interleukin (IL)-6 and granulocyte-colony stimulating factor (G-CSF) were high. Right upper lobectomy and chest wall resection was performed. Histological diagnosis was large cell carcinoma. Immunohistological examination of lung tumor cells showed positive staining for G-CSF in only 1% of them. We diagnosed that tumor was G-CSF producing tumor and we thought that tumor produced IL-6.
authors.affiliation: Department of Chest Surgery, National Hospital Organization Sanyo Hospital, Ube, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Matsuda
authors.forename: K
authors.initials: K
authors.lastname: Okabe
authors.forename: T
authors.initials: T
authors.lastname: Yagi
authors.forename: H
authors.initials: H
authors.lastname: Tao
authors.forename: K
authors.initials: K
authors.lastname: Hirazawa
authors.forename: T
authors.initials: T
authors.lastname: Murakami
authors.forename: K
authors.initials: K
authors.lastname: Sugi
mesh_terms: D018287:Carcinoma, Large Cell / Q000097:blood*; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008175:Lung Neoplasms / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000097:blood*
chemical_list: D015850:Interleukin-6; D016179:Granulocyte Colony-Stimulating Factor