title: Cl- conduction of GABA(A)-receptor complex of synaptic membranes of rat brain cortex after development of chronic epileptization of the brain (pharmacological kindling).
abstract: Experiments on Wistar rats showed that basal and muscimol-induced 36Cl- entry into synaptoneurosomes isolated from the brain cortex decreased after kindling (30 mg/kg pentylenetetrazole intraperitoneally for 30 days) in animals with seizure severity score 4-5. Changes in Cl- conduction during kindling are discussed.
authors.affiliation: Laboratory of Epileptogenesis, Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
authors.forename: I G
authors.initials: IG
authors.lastname: Rebrov
authors.forename: M N
authors.initials: MN
authors.lastname: Karpova
authors.forename: A A
authors.initials: AA
authors.lastname: Andreev
authors.forename: N Y
authors.initials: NY
authors.lastname: Klishina
authors.forename: M V
authors.initials: MV
authors.lastname: Kalinina
authors.forename: L V
authors.initials: LV
authors.lastname: Kusnetzova
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D002712:Chlorides / Q000378:metabolism*; D002713:Chlorine; D007696:Kindling, Neurologic / Q000502:physiology*; D008297:Male; D009118:Muscimol / Q000494:pharmacology; D010433:Pentylenetetrazole / Q000494:pharmacology; D011868:Radioisotopes; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000378:metabolism*; D013570:Synaptic Membranes / Q000187:drug effects / Q000502:physiology*
chemical_list: D002712:Chlorides; D011868:Radioisotopes; D011963:Receptors, GABA-A; D009118:Muscimol; D002713:Chlorine; D010433:Pentylenetetrazole