[The preparation of bioglass/collagen/phosphoserine biomemetic composite scaffold and a study on its cytocompatibility].
In the present study, novel biomemetic composite scaffolds using the sol-gel derived bioactive glass (BG), collagen (COL), and phosphoserine (PS) were prepared by freeze-drying. MC3T3-E1 were cultivated in vitro, collected and seeded onto the surface of BG, BG-COL and BG-COL-PS. Cell attachment and proliferation were observed. The cell proliferation was tracked by MTT method 1,3,5 d after seeding. MTT showed that the cells can adhere to and proliferate well on the surface of the scaffolds, and the cell proliferation result of scaffold BG-COL-PS was better than those of scaffolds BG and BG-COL. Therefore, the scaffold BG-COL-PS can be a potential scaffold for tissue engineer.
Chen
Xiaofeng
X
Biomaterials Research Institute, College of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China. chenxf@scut.edu.cn
Li
Xiangjun
X
Wang
Yingjun
Y
Yang
Chunrong
C
Zhao
Naru
N
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D040761:Biomimetic Materials / Q000138:chemical synthesis*; D002460:Cell Line; D049109:Cell Proliferation; D002516:Ceramics / Q000737:chemistry*; D003094:Collagen / Q000737:chemistry*; D051379:Mice; D010006:Osteoblasts / Q000166:cytology; D010768:Phosphoserine / Q000737:chemistry*; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds
D001672:Biocompatible Materials; C022107:Bioglass; D010768:Phosphoserine; D003094:Collagen