title: Exercise and the treatment of diabetes and obesity.
abstract: Lifestyle intervention programs encompassing exercise and healthy diets are an option for the treatment and management of obesity and type 2 diabetes and have long been known to exert beneficial effects on whole-body metabolism, in particular leading to enhanced insulin-sensitivity. Obesity is associated with increased risk of several illnesses and premature mortality. However, physical inactivity is itself associated with a number of similar risks, independent of body-mass index, and is an independent risk factor for more than 25 chronic diseases, including type 2 diabetes and cardiovascular disease. This article addresses the debate regarding the relative effects of physical exercise itself and the effect of exercise-induced weight loss.
authors.affiliation: School of Health and Human Performance, Dublin City University, Dublin, Ireland.
authors.forename: Donal J
authors.initials: DJ
authors.lastname: O'Gorman
authors.forename: Anna
authors.initials: A
authors.lastname: Krook
mesh_terms: D000818:Animals; D003920:Diabetes Mellitus / Q000235:genetics / Q000378:metabolism / Q000628:therapy*; D015444:Exercise / Q000502:physiology; D005081:Exercise Therapy / Q000379:methods; D005786:Gene Expression Regulation / Q000502:physiology; D014644:Genetic Variation / Q000502:physiology; D006801:Humans; D009119:Muscle Contraction / Q000235:genetics; D018482:Muscle, Skeletal / Q000378:metabolism / Q000502:physiology; D009765:Obesity / Q000235:genetics / Q000378:metabolism / Q000628:therapy*