Effects of smoking on the pharmacokinetics and pharmacodynamics of a nicotine patch.
The effect of smoking on the pharmacokinetics and pharmacodynamics of a nicotine transdermal delivery system, administered as a single dose or multiple doses, was examined in smokers (n=12) and nonsmokers (n=12). The study was a two-period, parallel trial. In the first period, a single dose of the Nicotinell TTS 20 patch was administered, followed by a 1-week washout period. Then, in the second period, multiple doses of the Nicotinell TTS 20 patch were administered over 4 days. Regarding the pharmacokinetics of nicotine, the AUC(36 h) and AUC(tau) of smokers were about 20% and 40% greater, respectively, than those of nonsmokers. Significant differences in heart rate were observed between smokers and nonsmokers at 10, 12, 16 and 24 h, and significant differences in systolic blood pressure were seen between smokers and nonsmokers at 12, 30 and 36 h in the single-dose study. With multiple doses, significant differences in systolic and diastolic blood pressures were detected between smokers and nonsmokers only at 72.5 and 82 h. Here, it is demonstrated for the first time that the pharmacokinetic and hemodynamic effects of a nicotine patch are significantly different between smokers and nonsmokers.
Yun
Hwi-yeol
HY
Drug Discovery Laboratory (PK), Central Research Institute, Choongwae Pharma Corporation, Kyonggi, Korea.
Seo
Jeong-won
JW
Choi
Ji-eun
JE
Baek
In-hwan
IH
Kang
Wonku
W
Kwon
Kwang-il
KI
D000279:Administration, Cutaneous; D000328:Adult; D019540:Area Under Curve; D001794:Blood Pressure / Q000187:drug effects; D003367:Cotinine / Q000097:blood; D004334:Drug Administration Schedule; D004347:Drug Interactions; D005260:Female; D006207:Half-Life; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D009538:Nicotine / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D018722:Nicotinic Agonists / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D012907:Smoking / Q000009:adverse effects* / Q000378:metabolism / Q000503:physiopathology; D055815:Young Adult
D018722:Nicotinic Agonists; D009538:Nicotine; D003367:Cotinine