Public health genomics: translating obesity genomics research into population health benefits.
We examine how a public health genomics framework can be used to move genomic discoveries into clinical and public health practice for obesity prevention and treatment. There are four phases of translational research: T1: discovery to candidate health application; T2: health application to evidence-based practice guidelines; T3: practice guidelines to health practice; and T4: practice to population health impact. Types of multidisciplinary research and knowledge synthesis needed for each phase, as well as the importance of developing and disseminating evidence-based guidelines, are discussed. Because obesity genomics research is mostly in the discovery phase or in the very early phases of translation (T1), the authors present this framework to illustrate the range of translation activities needed to move genomic discoveries in obesity to actual applications that reduce the burden of obesity at the population level.
Agurs-Collins
Tanya
T
Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. collinsta@mail.nih.gov
Khoury
Muin J
MJ
Simon-Morton
Denise
D
Olster
Deborah H
DH
Harris
Jennifer R
JR
Milner
John A
JA
D001525:Behavioral Sciences / Q000379:methods; D004777:Environment; D019317:Evidence-Based Medicine / Q000379:methods; D036281:Genetic Research; D005820:Genetic Testing / Q000379:methods; D005828:Genetics, Population / Q000379:methods; D023281:Genomics; D015438:Health Behavior; D006801:Humans; D033181:Information Dissemination / Q000379:methods; D009765:Obesity / Q000235:genetics* / Q000517:prevention & control / Q000628:therapy; D011634:Public Health / Q000379:methods*