Coarse-grained modeling of interactions of lipid bilayers with supports.
We characterize the differences between supported and unsupported lipid bilayer membranes using a mesoscopic simulation model and a simple particle-based realization for a flat support on to which the lipids are adsorbed. We show that the nanometer roughness of the support affects membrane binding strength very little. We then compare the lipid distributions and pressure profiles of free and supported membranes. The surface localization of the proximal leaflet breaks the symmetry seen in a free bilayer, and we quantify the entropic penalty for binding and the increased lateral compression modulus.
Hoopes
Matthew I
MI
Graduate Group in Biophysics, University of California, Davis, California 95616, USA.
Deserno
Markus
M
Longo
Margie L
ML
Faller
Roland
R
D004548:Elasticity; D008051:Lipid Bilayers / Q000737:chemistry*; D008956:Models, Chemical; D011312:Pressure; D013499:Surface Properties; D014867:Water / Q000737:chemistry
D008051:Lipid Bilayers; D014867:Water