Misoprostol and congenital anomalies.
Purpose- To evaluate the risk of having a baby with congenital anomalies in mothers who used misoprostol during pregnancy.Methods- Hospital-based case - control study from Hospital Chateaubriand, Fortaleza, Brasil. Cases were 37 babies weighing less than 1500 g with congenital anomalies of various types, and the comparison group included 387 infants also weighing less than 1500 g, and without congenital anomalies.Results- The multivariate odds ratio of having a baby with congenital anomalies was 2.4 (95% confidence interval 1.0 - 6.2) in mothers who reported having used misoprostol compared with those who did not.Conclusions- Misoprostol use during pregnancy might be related to a broad spectrum of congenital anomalies in infants. Copyright (c) 2000 John Wiley & Sons, Ltd.
Brasil
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Grupo de Prevenção ao Uso Indevido de Medicamentos, Federal University of Ceará, Fortaleza, Brazil.
Lutéscia Coelho
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H
D'Avanzo
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B
La Vecchia
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C