New multifunctional textile biomaterials for the treatment of leg venous insufficiency.
Acryloyl monomers have been synthesized by reaction of beta-cyclodextrin and troxerutin with acryloyl chloride and grafted on a knitted material obtained from polyamide 6.6 and polyurethane fibers. Polyamide grafted with beta-cyclodextrin derivative binds troxerutin as a physical complex. The obtained biomaterials have been tested in vivo on rats for their ability to deliver troxerutin (a flebotonic drug) to different skin areas (epidermis, dermis and vascular wall). The results showed that the new synthesized materials can act as multifunctional bioactive textiles that can display both compression (given by the textile material) and sustained venotonic and haemostatic properties (given by the troxerutin delivered from biomaterial to the skin).
Nichifor
M
M
Department of Bioactive and Biocompatible Polymers, P. Poni Institute of Macromolecular Chemistry, Gr. Ghica Voda 41A, Iasi, 700487, Romania. nichifor@icmpp.ro
Constantin
M
M
Mocanu
G
G
Fundueanu
G
G
Branisteanu
D
D
Costuleanu
M
M
Radu
C D
CD
D000818:Animals; D001672:Biocompatible Materials; D006614:Hindlimb / Q000098:blood supply*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008855:Microscopy, Electron, Scanning; D051381:Rats; D017208:Rats, Wistar; D017550:Spectroscopy, Fourier Transform Infrared; D013784:Textiles; D014689:Venous Insufficiency / Q000628:therapy*
D001672:Biocompatible Materials