Lighting up the stressed ER.
Balancing the capacity for protein maturation with changes in protein flux through the endoplasmic reticulum (ER) is crucial for maintaining ER homeostasis. In this issue, Merksamer et al. (2008) exploit a redox-sensitive fluorescent protein to monitor the environment inside the ER of living yeast, illuminating how this organelle responds to different perturbations.
Kang
Sang-Wook
SW
National Institutes of Health, Bethesda, MD 20892, USA.
Hegde
Ramanujan S
RS
D004721:Endoplasmic Reticulum / Q000502:physiology*; D010084:Oxidation-Reduction; D017510:Protein Folding; D012441:Saccharomyces cerevisiae / Q000502:physiology*; D013312:Stress, Physiological