title: Tick subolesin is an ortholog of the akirins described in insects and vertebrates.
abstract: The tick protective antigen, subolesin, is a regulatory protein involved in the control of multiple cellular pathways. Subolesin is evolutionary conserved in invertebrates and vertebrates with sequence homology to akirins, a recently renamed group of proteins that were proposed to function as transcription factors in Drosophila and mice. The objective of this research was to provide evidence of the sequence and functional homology between tick subolesin and akirins. The phylogenetic analysis of subolesin and akirins showed that they are evolutionary conserved. The effect of subolesin and akirin2 knockdown was compared in adult ticks and mice, respectively. The results demonstrated that tick subolesin is an ortholog of insect and vertebrate akirins and suggested that these proteins function in the regulation of NF-kappaB-dependent and independent expression of signal transduction and innate immune response genes. These results suggest that these proteins have an important role in host-pathogen interactions.
authors.affiliation: Instituto de Investigación en Recursos Cinegéticos IREC (CSIC-UCLM-JCCM), Ronda de Toledo s/n, 13005 Ciudad Real, Spain.
authors.forename: Ruth C
authors.initials: RC
authors.lastname: Galindo
authors.forename: Ernesto
authors.initials: E
authors.lastname: Doncel-Pérez
authors.forename: Zorica
authors.initials: Z
authors.lastname: Zivkovic
authors.forename: Victoria
authors.initials: V
authors.lastname: Naranjo
authors.forename: Christian
authors.initials: C
authors.lastname: Gortazar
authors.forename: Atilio J
authors.initials: AJ
authors.lastname: Mangold
authors.forename: María Paz
authors.initials: MP
authors.lastname: Martín-Hernando
authors.forename: Katherine M
authors.initials: KM
authors.lastname: Kocan
authors.forename: José
authors.initials: J
authors.lastname: de la Fuente
mesh_terms: D000818:Animals; D000941:Antigens / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D015536:Down-Regulation / Q000235:genetics; D015870:Gene Expression / Q000235:genetics; D055785:Gene Knockdown Techniques; D007313:Insecta / Q000235:genetics / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009687:Nuclear Proteins; D010802:Phylogeny; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D034622:RNA Interference; D012097:Repressor Proteins; D015398:Signal Transduction / Q000235:genetics; D013987:Ticks / Q000235:genetics / Q000276:immunology*; D014157:Transcription Factors / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D000097782:NF-kappaB-Inducing Kinase
chemical_list: D000941:Antigens; D009687:Nuclear Proteins; D017346:Protein Serine-Threonine Kinases; D011506:Proteins; D012097:Repressor Proteins; D014157:Transcription Factors; D000097782:NF-kappaB-Inducing Kinase; C559424:Akirin1 protein, mouse; C559423:Akirin2 protein, mouse