Carotid intimomedial thickness in type 2 diabetic patients and its correlation with coronary risk factors.
OBJECTIVE
To compare the carotid intimal-medial thickness in type 2 diabetics with and without coronary artery disease (CAD), and to correlate the intimal-medial thickness (IMT) with known coronary risk factors.


METHODS
One hundred and eleven patients of type 2 diabetes were recruited for the study. History and physical examination were recorded. Laboratory investigations included fasting and 2-hour post-prandial blood sugar, blood urea, serum creatinine, lipid profile, glycated haemoglobin, and microalbuminuria. Ultrasonographic scanning of the carotid arteries was performed to measure the carotid IMT. For identification of cases of silent ischaemia, treadmill test (TMT) was performed.


RESULTS
The study group was divided into a non-CAD group (n=40), and a CAD group (n=71). The mean carotid IMT of the group as a whole, was 0.840 +/- 0.2 mm. The mean carotid IMT was significantly higher (p<0.0001) in type 2 diabetics with CAD (both overt and silent) than in those without CAD. In diabetics with CAD, the systolic blood pressure, diastolic blood pressure and triglycerides were found to be predictors of high mean carotid IMT. On subgroup analysis of the cases with silent ischaemia, the variables affecting carotid IMT were serum creatinine, total cholesterol, microalbuminuria/proteinuria, serum triglyceride levels, and diastolic blood pressure.


CONCLUSIONS
A high carotid IMT is a surrogate and reliable marker of higher risk of CAD amongst type 2 diabetic patients, even in those without overt CAD. The study underlines the utility of carotid IMT as a simple, non-invasive, safe, and cheap screening test for the assessment of risk/prognosis of CAD in type 2 diabetics. We have also demonstrated the usefulness of measuring IMT, as a means to detect silent CAD among type 2 diabetics.
Agarwal
A K
AK
Department of Medicine, Dr. RML Hospital and PGIMER, New Delhi-110001.
Gupta
P K
PK
Singla
S
S
Garg
U
U
Prasad
A
A
Yadav
R
R
D015415:Biomarkers; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology*; D002340:Carotid Artery Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology*; D003324:Coronary Artery Disease; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D005080:Exercise Test; D005215:Fasting; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D019518:Postprandial Period; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D017539:Tunica Intima / Q000000981:diagnostic imaging / Q000473:pathology*; D014463:Ultrasonography
D015415:Biomarkers