title: Effects of lysed Enterococcus faecalis FK-23 on allergen-induced peritoneal accumulation of eosinophils and serum total IgE concentration in inbred mice.
abstract: Recent clinical trials have shown the possibility of probiotics in prevention and treatment of allergic diseases. The purpose of this experimental study was to assess the influence of lysed Enterococcus faecalis FK-23 (LFK) on allergic responses in different mouse strains. We performed a comparative study on the effects of LFK for allergen-induced peritoneal accumulation of eosinophils and serum total IgE concentration by using BALB/c, C57BL/6, C3H/HeN and C3H/HeJ mice. There was no significant difference in total number of peritoneal accumulated cells induced by cedar pollen allergen between the control and LFK groups in any strain of mice (p > 0.05); however, the ratio of eosinophils to total accumulated cells was significantly decreased in LFK-treated mice of BALB/c (p = 0.016), C3H/HeN (p = 0.010) and C3H/HeJ (p = 0.004), but not C57BL/6 (p > 0.05). No significant difference in serum total IgE concentration was found between the control and LFK groups of different mouse strains (p > 0.05). These results reveal a different effect of LFK on suppressing allergen-induced local eosinophila in inbred strains of mice, suggesting the effectiveness of probiotics on limiting allergy might be under the influence of individual genetic background.
authors.affiliation: Central Research Laboratories, Nichinichi Pharmaceutical Co. Ltd., Mie, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Shimada
authors.forename: Lu-Ping
authors.initials: LP
authors.lastname: Zhu
authors.forename: Min
authors.initials: M
authors.lastname: Yin
authors.forename: Chie
authors.initials: C
authors.lastname: Motonaga
authors.forename: Hua-Bin
authors.initials: HB
authors.lastname: Li
authors.forename: Hai-Bo
authors.initials: HB
authors.lastname: Shi
authors.forename: Keisuke
authors.initials: K
authors.lastname: Enomoto
authors.forename: Tadao
authors.initials: T
authors.lastname: Enomoto
authors.forename: Lei
authors.initials: L
authors.lastname: Cheng
mesh_terms: D000818:Animals; D052179:Antigens, Plant; D032485:Cryptomeria; D013293:Enterococcus faecalis / Q000737:chemistry / Q000276:immunology*; D004804:Eosinophils / Q000276:immunology / Q000473:pathology; D005260:Female; D007073:Immunoglobulin E / Q000097:blood* / Q000276:immunology; D007165:Immunosuppression Therapy; D007958:Leukocyte Count; D051379:Mice; D008815:Mice, Inbred Strains; D010537:Peritoneum / Q000276:immunology* / Q000473:pathology; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D011058:Pollen; D006255:Rhinitis, Allergic, Seasonal / Q000097:blood / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control; D013045:Species Specificity
chemical_list: D052179:Antigens, Plant; D004364:Pharmaceutical Preparations; D007073:Immunoglobulin E