Spreading of an anchorage-dependent cell on a selectively ligand-coated substrate mediated by receptor-ligand binding.
A continuum model was proposed to simulate a biological cell adhering to a substrate surface domain with selectively coated ligands. Cell adhesion was modeled by a traction-separation law depending on the receptor-ligand distance and their densities. It was found that the obtained spreading patterns are consistent with published experimental data and that adhesion requires a nonuniform distribution of receptors at the spreading front with convex fronts requiring a much higher receptor density than concave fronts. Adhesion strength was also found to be more influential than adhesion energy on the spreading kinetics.
Liu
Ping
P
Institute of High Performance Computing, Singapore 117352.
Zhang
Yong W
YW
Yu
Hanry
H
Zhang
Xin
X
Cheng
Qian H
QH
Lu
Chun
C
Bonfield
William
W
D000465:Algorithms; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002448:Cell Adhesion; D004058:Diffusion; D020342:Finite Element Analysis; D006801:Humans; D007700:Kinetics; D008024:Ligands; D008051:Lipid Bilayers / Q000737:chemistry; D015233:Models, Statistical; D011485:Protein Binding; D013499:Surface Properties
D001672:Biocompatible Materials; D008024:Ligands; D008051:Lipid Bilayers