Portulene, a new diterpene from Portulaca oleracea L.
Chromatographic fractionation of the chloroform extract of Portulaca oleracea L. growing in Egypt afforded a new clerodene diterpene portulene (1), in addition to the known compounds lupeol (2), beta-sitosterol (3), and daucosterol (4), which were reported for the first time from the title plant. The structures of the isolated compounds were unambiguously established through 1D, 2D, and mass spectral analyses. Co-treatment of CCl(4) hepatic injured rats with 70% alcohol extract of P. oleracea significantly restored the hepatic marker enzymes and total bilirubin to near-normal values, which demonstrated hepatoprotective activity. In addition, the P. oleracea extract showed antibacterial and antifungal activities.
Elkhayat
Ehab S
ES
Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University (Assiut Branch), Assiut, Egypt. khayat71@yahoo.com
Ibrahim
Sabrin R M
SR
Aziz
Mohamed A
MA
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D002252:Carbon Tetrachloride Poisoning; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology*; D008297:Male; D015394:Molecular Structure; D031822:Portulaca / Q000737:chemistry*; D051381:Rats
D000900:Anti-Bacterial Agents; D004224:Diterpenes; C539119:portulene