title: Toward an anatomy of disappointment: reward-related signals from the globus pallidus.
abstract: The globus pallidus (internal segment, GPi) is traditionally regarded as part of the motor system. In this issue of Neuron, Hong and Hikosaka report on a little known projection from the monkey GPi to the lateral habenula that is modulated by reward. This adds an important branch to the brain's reward circuitry.
authors.affiliation: Neurobiology Research Unit, Okinawa Institute of Science and Technology, 12-22 Suzaki, Uruma City, Okinawa, Japan. jeff.wickens@otago.ac.nz
authors.forename: Jeff
authors.initials: J
authors.lastname: Wickens
mesh_terms: D000818:Animals; D004298:Dopamine / Q000378:metabolism; D004644:Emotions / Q000502:physiology*; D005917:Globus Pallidus / Q000033:anatomy & histology / Q000502:physiology*; D019262:Habenula / Q000033:anatomy & histology / Q000502:physiology*; D006801:Humans; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology; D018377:Neurotransmitter Agents / Q000378:metabolism; D012054:Reinforcement, Psychology; D012201:Reward; D017557:Ventral Tegmental Area / Q000033:anatomy & histology / Q000502:physiology
chemical_list: D018377:Neurotransmitter Agents; D004298:Dopamine