Postural orthostatic tachycardia in a teenager with Klinefelter syndrome.
To our knowledge this is the first reported case of postural orthostatic tachycardia syndrome (POTS) in a patient with Klinefelter syndrome. We describe a classic clinical presentation of POTS in an adolescent male with Klinefelter syndrome. Although the etiology of POTS appears to be multifactorial, there is a strong female predominance that suggests a genetic basis. Our patient with Klinefelter syndrome may further support a link with POTS to the X chromosome.
Hainstock
Michael R
MR
University of Arizona College of Medicine, Department of Pediatrics, Tucson, AZ, USA. hainstoc@ohsu.edu
Gruchala
Nancy E
NE
Fike
Nadia
N
Samson
Ricardo A
RA
Klewer
Scott E
SE
Barber
Brent J
BJ
D000293:Adolescent; D041321:Chromosomes, Human, X; D004562:Electrocardiography; D005438:Fludrocortisone / Q000627:therapeutic use; D005440:Fluid Therapy; D006801:Humans; D007713:Klinefelter Syndrome / Q000150:complications* / Q000235:genetics / Q000628:therapy; D008297:Male; D054972:Postural Orthostatic Tachycardia Syndrome / Q000209:etiology* / Q000235:genetics / Q000628:therapy; D012737:Sex Factors
D005438:Fludrocortisone