Secure route to the epoxybicyclo[7.3.0]dodecadienediyne core of the kedarcidin chromophore.
Formation of an epoxide before 9-membered ring cyclization and SmI2 mediated reductive olefination in the presence of the epoxide successfully produced the epoxybicyclo[7.3.0]dodecadienediyne core of the kedarcidin chromophore.
Ogawa
Kouki
K
Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan.
Koyama
Yasuhito
Y
Ohashi
Isao
I
Sato
Itaru
I
Hirama
Masahiro
M