title: Tc-99m Depreotide SPECT/CT depicts myocardial involvement in a case of thrombotic thrombocytopenic purpura.
abstract: We report a case of thrombotic thrombocytopenic purpura (TTP) with cardiac involvement, imaged with Tc-99m depreotide. A 56-year-old man presented with fever, hematuria, and chest pain. Laboratory findings (angiopathic hemolytic anemia, thrombocytopenia, and uremia) were suggestive of TTP. Cardiac enzymes were elevated and diffuse left ventricular hypokinesis was demonstrated by echocardiography. Serum rheumatologic and virologic analysis were negative. A Tc-99m depreotide SPECT/CT study showed diffuse uptake in the myocardium, indicating inflammatory reaction to thrombotic/hemorrhagic myocardial damage. We suggest that Tc-99m depreotide imaging may reveal myocardial involvement in TTP; this could prompt further investigation for potential applications in myocarditis of other etiologies.
authors.affiliation: Department of Nuclear Medicine, University Hospital of Patras, Patras, Greece.
authors.forename: Tryfon
authors.initials: T
authors.lastname: Spiridonidis
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Patsouras
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Papandrianos
authors.forename: Argiris
authors.initials: A
authors.lastname: Symeonidis
authors.forename: Dimitris J
authors.initials: DJ
authors.lastname: Apostolopoulos
mesh_terms: D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D015609:Organotechnetium Compounds; D011697:Purpura, Thrombotic Thrombocytopenic / Q000000981:diagnostic imaging* / Q000473:pathology*; D013004:Somatostatin / Q000031:analogs & derivatives*; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D015609:Organotechnetium Compounds; D013004:Somatostatin; C444119:technetium Tc 99m depreotide