A cell wall-active lipopeptide from the fungus Pochonia bulbillosa.
Bioassay-directed fractionation of a fermentation of Pochonia bulbinosa, culture 38G272, led to the isolation of a series of structurally novel, prospective cell wall-active lipopeptides. The main component of this suite is 1, a linear hexapeptide with a delta-hydroxymyristic acid amide substituted N-terminus. The structure was deduced using high-field microsample NMR, Fourier transform mass spectrometry, and microscale chemical degradation. The potent cell wall activity and synthetically accessible structure of 1 make it a potential lead for further investigation.
Koehn
Frank E
FE
Natural Products Discovery and Discovery Analytical Chemistry, Chemical and Screening Sciences, Wyeth Research, Pearl River, New York 10965, USA. koehnf@wyeth.com
Kirsch
Donald R
DR
Feng
Xidong
X
Janso
Jeffrey
J
Young
Mairead
M
D000595:Amino Acid Sequence; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002473:Cell Wall / Q000737:chemistry / Q000378:metabolism; D003364:Costa Rica; D006999:Hypocreales / Q000737:chemistry*; D055666:Lipopeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
D000935:Antifungal Agents; D055666:Lipopeptides