title: Antidiabetic and antioxidant activities of major flavonoids of Cynanchum acutum L. (Asclepiadaceae) growing in Egypt.
abstract: Seven flavonoids were isolated from the butanol fraction of the methanolic extract of the aerial parts of Cynanchum acutum L. (Asclepiadaceae). All of which have been isolated for the first time from the genus Cynanchum. Their structures were established as quercetin 3-O-beta-galacturonopyranoside (1), quercetin 7-O-beta-glucopyranoside (2), tamarixtin 3-O-beta-galacturonopyranoside (3), kaempferol 3-O-beta-galacturonopyranoside (4), 8-hydroxyquercetin 3-O-beta-galactopyranoside (5), tamarixtin 3-O-alpha-rhamnopyranoside (6), and tamarixtin 7-O-alpha-arabinopyranoside (7) on the basis of their chromatographic properties, chemical and spectroscopic data. The major isolated flavonoids 1, 2 and 3 were found to exhibit significant antioxidant and antidiabetic activities (by measuring blood glucose and insulin levels). This is the first report about the antioxidant and antidiabetic activities of compounds 1-3.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr-El-Aini St., 11562 Cairo, Egypt.
authors.forename: Ghada A
authors.initials: GA
authors.lastname: Fawzy
authors.forename: Hossam M
authors.initials: HM
authors.lastname: Abdallah
authors.forename: Mohamed S A
authors.initials: MS
authors.lastname: Marzouk
authors.forename: Fathy M
authors.initials: FM
authors.lastname: Soliman
authors.forename: Amany A
authors.initials: AA
authors.lastname: Sleem
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D031105:Cynanchum / Q000737:chemistry* / Q000254:growth & development; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004534:Egypt; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D005978:Glutathione / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000627:therapeutic use; D007928:Lethal Dose 50; D008297:Male; D008687:Metformin / Q000627:therapeutic use; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D005419:Flavonoids; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D008687:Metformin; D005978:Glutathione