title: Evaluation of body development, fat mass and lipid profile in rats fed with high-PUFA and -MUFA diets, after neonatal malnutrition.
abstract: Neonatal malnutrition is associated with several features of the metabolic syndrome, later in life. Although the recovery of malnutrition was studied with different high-fat diets, few studies compare the effects of enriched vegetable oil diets, containing PUFA and MUFA, after weaning. Our aim was to evaluate the recovery with soya oil- or rapeseed oil-enriched diet, after malnutrition in rats whose mothers were food restricted (FR) during lactation. Dams were 50 % FR and compared to standard diet-fed dams (control, C). At 21 d, FR offspring had a lower body mass and length. After weaning C and FR offspring were fed a diet containing 7 % soya oil (7 %sC and 7 %sFR), or supplemented with 19 % soya oil (19 %sC or 19 %sFR) or 19 % rapeseed oil (19 %cC or 19 %cFR). The normal animals fed enriched vegetable oil diets had more visceral fat mass, but lower serum TAG and higher HDL-cholesterol. The 19 %FR groups showed significantly less food intake and body development compared to the 7 %sFR, and the same pattern was observed when this group was compared to the C groups. Absolute and relative mass of vital organs and body were lower in the FR groups. Visceral fat depot was lower in 19 %FR than 7 %FR and C groups. Serum glucose, albumin, TAG, cholesterol, leptin and triiodothyronine did not show significant changes. However, 19 %FR groups showed higher HDL-cholesterol and the 19 %sFR group showed lower serum thyroxine. The data suggest that a higher vegetable oil diet in the recovery of neonatal malnutrition ameliorates some features of the metabolic syndrome later in life.
authors.affiliation: Departamentos de Ciências Fisiológicas, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Av. 28 de setembro, 87f, Rio de Janeiro, RJ 20551-030, Brazil.
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: Soares da Costa
authors.forename: Erika Gomes
authors.initials: EG
authors.lastname: Alves
authors.forename: Gabrielle
authors.initials: G
authors.lastname: de Paula Lopes Gonzalez
authors.forename: Thais Barcellos Côrtes
authors.initials: TB
authors.lastname: Barbosa
authors.forename: Aluana Santana
authors.initials: AS
authors.lastname: Carlos
authors.forename: Verônica Demarco
authors.initials: VD
authors.lastname: Lima
authors.forename: Renata
authors.initials: R
authors.lastname: Nascimento
authors.forename: Egberto Gaspar
authors.initials: EG
authors.lastname: de Moura
authors.forename: Celly Cristina
authors.initials: CC
authors.lastname: Alves do Nascimento-Saba
mesh_terms: D000273:Adipose Tissue / Q000473:pathology*; D050154:Adiposity / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000502:physiology; D004435:Eating / Q000502:physiology; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage*; D008055:Lipids / Q000097:blood*; D044342:Malnutrition / Q000097:blood / Q000473:pathology / Q000503:physiopathology*; D009929:Organ Size / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D015430:Weight Gain / Q000502:physiology
chemical_list: D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated; D008055:Lipids