Imaging in multicentric Castleman's disease.
Multicentric Castleman[']s disease (MCD) is an uncommon lymphoproliferative disorder that presents with fevers, anaemia and multifocal lymphadenopathy and nowadays is most commonly diagnosed in individuals infected with HIV-1. CT scan findings are not sufficiently reliable to establish a diagnosis of MCD which requires histological confirmation. Newer imaging techniques have therefore been studied in patients with HIV-associated MCD in an attempt to improve diagnostic accuracy. Preliminary findings suggest that FDG PET-CT may assist in the monitoring of disease activity in MCD along with familiar clinical and laboratory tools and the more recently introduced plasma HHV8 DNA viral load measurement.
Barker
Robert
R
Department of Oncology, Imperial College School of Medicine, London, UK.
Kazmi
Fahrad
F
Bower
Mark
M
D015658:HIV Infections; D015497:HIV-1; D019288:Herpesvirus 8, Human; D006801:Humans; D008232:Lymphoproliferative Disorders; D010949:Plasma; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed