title: Cognitive-performance recovery of Alzheimer's disease model mice by modulation of early soluble amyloidal assemblies.
abstract: A rationally designed oligomerization inhibitor interacts with early intermediate assemblies of amyloid-beta polypeptide (Abeta) through the aromatic elements and inhibits their assembly into the toxic oligomers that cause Alzheimer's disease by a unique C(alpha)-methylation beta-breakage strategy. The electrostatic potential of the low-energy conformation of the dipeptide inhibitor bound to Abeta is shown.
authors.affiliation: Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel.
authors.forename: Anat
authors.initials: A
authors.lastname: Frydman-Marom
authors.forename: Meirav
authors.initials: M
authors.lastname: Rechter
authors.forename: Irit
authors.initials: I
authors.lastname: Shefler
authors.forename: Yaron
authors.initials: Y
authors.lastname: Bram
authors.forename: Deborah E
authors.initials: DE
authors.lastname: Shalev
authors.forename: Ehud
authors.initials: E
authors.lastname: Gazit
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D016229:Amyloid beta-Peptides / Q000737:chemistry* / Q000378:metabolism; D000818:Animals; D001812:Blood-Brain Barrier; D002460:Cell Line; D004151:Dipeptides / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D005454:Fluorescence Polarization; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008822:Mice, Transgenic; D016716:PC12 Cells; D051381:Rats; D055672:Static Electricity
chemical_list: D016229:Amyloid beta-Peptides; D004151:Dipeptides