Preference for gel over suppository as delivery vehicle for a rectal microbicide: results of a randomised, crossover acceptability trial among men who have sex with men.
OBJECTIVE
To assess whether men who have sex with men (MSM) prefer a gel or a suppository as a delivery vehicle for a rectal microbicide.


METHODS
77 HIV-negative MSM with a recent history of inconsistent condom use during receptive anal intercourse (RAI) who acknowledged being at risk of contracting HIV were enrolled in a randomised, crossover acceptability trial. They compared 35 ml placebo gel with 8 g placebo rectal suppositories used on up to three RAI occasions each.


RESULTS
Participants preferred the gel over the suppository (75% versus 25%, p<0.001) and so did their partners (71% versus 29%, p<0.001). The gel received more favourable ratings overall and on attributes such as colour, smell, consistency, feeling in rectum immediately after insertion and/or 30 minutes after insertion and application process. The gel resulted in less negative ratings in terms of participants being bothered by leakage, soiling, bloating, gassiness, stomach cramps, urge to have bowel movement, diarrhoea, pain or trauma. Participants liked the gel more in terms of feelings during anal sex, sexual satisfaction, partners' sexual satisfaction and liking the product when condoms were used and when condoms were not used.


CONCLUSIONS
In this sample taken from one of the populations most likely to benefit from rectal microbicide availability, gel had greater acceptability than a suppository as a potential microbicide vehicle.
Carballo-Diéguez
A
A
Unit 15, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA. ac72@columbia.edu
Dolezal
C
C
Bauermeister
J A
JA
O'Brien
W
W
Ventuneac
A
A
Mayer
K
K
D000293:Adolescent; D000328:Adult; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D017280:Condoms / Q000706:statistics & numerical data; D018592:Cross-Over Studies; D004867:Equipment Design; D005782:Gels; D018451:Homosexuality, Male / Q000523:psychology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D014677:Pharmaceutical Vehicles; D012747:Sexual Partners / Q000523:psychology; D013488:Suppositories; D047568:Unsafe Sex / Q000523:psychology; D055815:Young Adult
D000891:Anti-Infective Agents, Local; D005782:Gels; D014677:Pharmaceutical Vehicles; D013488:Suppositories