Evaluation of the dependence of mutagenesis intensity on activity of nucleolus organizer regions of chromosomes in Aboriginal population of Kursk region.
Visual semiquantitative method of silver staining of nucleolus organizer regions in peripheral blood leukocytes was applied for evaluation of the correlation between activity of nucleolus organizer regions and the level of chromosome aberrations in 241 residents of Kursk region. Significant differences in the percent of chromosome aberrations were revealed between three groups differing by the number of active nucleolus organizer regions, which can be explained by different proliferative activity in these groups. The lowest level of chromosome aberrations was found in individuals with high transcription activity of the nucleolus organizer regions (due to high proliferative activity in this group and due to more intensive protein biosynthesis, e.g., synthesis of reparation enzymes). The maximum level of chromosome aberrations was observed in the group with medium number of active nucleolus organizer regions (adaptive norm).
Amelina
I V
IV
Kursk Institute of Social Education, Branch of Russian State Social University.
Medvedev
I N
IN
D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000235:genetics* / Q000378:metabolism; D005006:Ethnicity / Q000235:genetics*; D006801:Humans; D016296:Mutagenesis; D009697:Nucleolus Organizer Region / Q000235:genetics / Q000378:metabolism*; D010641:Phenotype; D012426:Russia; D014158:Transcription, Genetic