title: Comparison of the behavior of natural and refilled porcine lenses in a robotic lens stretcher.
abstract: The mechanism by which the eye dynamically changes focal distance (accommodation), and the mechanism by which this ability is lost with age (presbyopia), are still contested. Due to inherent confounding factors in vivo, in vitro measurements have been undertaken using a robotic lens stretcher to examine these mechanisms as well as the efficacy of lens refilling - a proposed treatment for presbyopia. Dynamic forces, anterior and posterior curvatures, and lens thickness are all correlated for young natural and refilled porcine lenses. Comparisons are made to lenses refilled with a homogeneous polymer system. The amplitude of accommodation of the young porcine lens is very small such that it may be a suitable model for presbyopia. The behavior of refilled lenses was highly dependent on the refill volume. The volume could be tuned to maximize accommodative amplitude in the refilled lens.
authors.affiliation: Department of Veterans Affairs Medical Center JC, Washington University in St Louis, St Louis, MO 63110, USA. mar4@cec.wustl.edu
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Reilly
authors.forename: Paul D
authors.initials: PD
authors.lastname: Hamilton
authors.forename: Gavin
authors.initials: G
authors.lastname: Perry
authors.forename: Nathan
authors.initials: N
authors.lastname: Ravi
mesh_terms: D000065:Accommodation, Ocular; D000818:Animals; D004548:Elasticity; D004867:Equipment Design; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007908:Lens, Crystalline / Q000502:physiology* / Q000503:physiopathology / Q000601:surgery; D011305:Presbyopia / Q000503:physiopathology* / Q000601:surgery; D012029:Refraction, Ocular; D012371:Robotics / Q000295:instrumentation; D034421:Sus scrofa