title: Considerations for implantation site of VX2 carcinoma into rabbit liver.
abstract: OBJECTIVE
  To assess whether the implantation site of VX2 carcinoma into rabbit liver affects successful vessel selection for transcatheter arterial interventions.
  
  
  METHODS
  Twenty-four New Zealand White rabbits were randomly assigned to two groups. All implantations were performed by open laparotomy with minced tumor cells inserted into a 16-gauge Angiocath needle. Group I rabbits (n = 12) had tumor implanted into the left medial lobe of the liver and group II rabbits (n = 12) had tumor implanted into the left lateral lobe. Two weeks after implantation, selective angiography was performed for subsequent chemoembolization, which was part of a different study. Tested variables included maximum tumor diameter, tumor feeding artery size, and tumor vascularity.
  
  
  RESULTS
  Successful tumor growth was achieved in all rabbits. Selective angiography was possible in 33.3% of rabbits in group I and 66.6% of rabbits in group II (P < .05). Tumor size and vascularity were similar between groups. Mean lengths of tumor feeder arteries from the bifurcation of the left hepatic artery were 4.1 mm +/- 1.2 in group I (left medial lobe) and 10.8 mm +/- 3.0 in group II (left lateral lobe; P < .05). The angulation of the left medial lobar artery (group I) off the left hepatic artery was acute in eight of 12 rabbits (66.6%), but only four of 12 rabbits in group II (33.3%) showed acute angulation of the left lateral lobar artery off the left hepatic artery (P < .05). Mean angiography time was significantly shorter in group II.
  
  
  CONCLUSIONS
  For selective hepatic arterial interventions, the left lateral lobe of the liver may be favorable as an implantation site for VX2 tumors in rabbits.
authors.affiliation: Division of Vascular and Interventional Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
authors.forename: Kwang-Hun
authors.initials: KH
authors.lastname: Lee
authors.forename: Eleni
authors.initials: E
authors.lastname: Liapi
authors.forename: Manon
authors.initials: M
authors.lastname: Buijs
authors.forename: Josephina
authors.initials: J
authors.lastname: Vossen
authors.forename: Kelvin
authors.initials: K
authors.lastname: Hong
authors.forename: Christos
authors.initials: C
authors.lastname: Georgiades
authors.forename: Jean-Francois H
authors.initials: JF
authors.lastname: Geschwind
mesh_terms: D015901:Angiography, Digital Subtraction; D000818:Animals; D002277:Carcinoma / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy; D016461:Chemoembolization, Therapeutic; D006499:Hepatic Artery / Q000000981:diagnostic imaging; D007267:Injections; D008114:Liver Neoplasms, Experimental / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy; D008297:Male; D009368:Neoplasm Transplantation; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging; D011817:Rabbits