title: An effective O-demethylation of some C19-diterpenoid alkaloids with HBr-glacial acetic acid.
abstract: The aconitine-type alkaloids talatisamine (1), 8,14-diacetyltalatisamine (11), and compound 3, the lycoctonine-type alkaloid deltaline (5), and the 7,17-seco C(19)-diterpenoid alkaloids 7 and 9 were treated with HBr-glacial acetic acid to give useful O-demethylated derivatives 2, 2, 4, 6, 8, and 10 respectively in good to high yields (49-90%).
authors.affiliation: Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu, China.
authors.forename: Chun-Lan
authors.initials: CL
authors.lastname: Zou
authors.forename: Hong
authors.initials: H
authors.lastname: Ji
authors.forename: Guang-Bo
authors.initials: GB
authors.lastname: Xie
authors.forename: Dong-Lin
authors.initials: DL
authors.lastname: Chen
authors.forename: Feng-Peng
authors.initials: FP
authors.lastname: Wang
mesh_terms: D019342:Acetic Acid / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry*; D018054:Hydrobromic Acid / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000470:Alkaloids; D004224:Diterpenes; D018054:Hydrobromic Acid; D019342:Acetic Acid