[The histological picture of CRF in kidney grafts].
The most common immunological causes of delayed renal function failure in kidney grafts are recurrent glomerular disease, de novo glomerulonephritis, and chronic cellular or antibody-mediated rejection. Glomerulonephritis can recur any time in the natural history of renal allografts, with the same morphological features of the disease occurring in the native kidney. It has a frequency varying from 100% to 1% and a generally favorable prognosis with the exception of FSGS, SHU and diabetic glomerulosclerosis. The most frequent glomerular diseases to occur de novo in the kidney graft are membranous glomerulopathy, antiglomerular basement membrane disease in patients with Alport's syndrome, and nephrotic syndrome of the Finnish type with antinephrin antibodies in patients with NPHS1 gene mutations. Chronic rejection, including chronic transplant arteriopathy and chronic transplant glomerulopathy, is the cause of renal failure in up to 20% of kidney grafts and may occur as early as a few months after transplant.
Mazzucco
G
G
Dipartimento di Scienze Biomediche ed Oncologia Umana, Università degli Studi, Torino, Italy. gianna. mazzucco@unito.it
D019867:Anti-Glomerular Basement Membrane Disease / Q000473:pathology; D005921:Glomerulonephritis / Q000473:pathology; D015433:Glomerulonephritis, Membranous / Q000473:pathology; D006084:Graft Rejection; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000473:pathology*; D007678:Kidney Glomerulus / Q000473:pathology*; D016030:Kidney Transplantation; D009404:Nephrotic Syndrome / Q000473:pathology; D012307:Risk Factors