title: FIO2 and acute respiratory distress syndrome definition during lung protective ventilation.
abstract: OBJECTIVE
  PaO2/FIO2 ratio (P/F) is the marker of hypoxemia used in the American-European Consensus Conference on lung injury. A high FIO2 level has been reported to variably alter PaO2/FIO2. We investigated the effect of high FIO2 levels on the course of P/F in lung protective mechanically ventilated patients with acute respiratory distress syndrome.
  
  
  METHODS
  Prospective, controlled, interventional study.
  
  
  METHODS
  University teaching French medical intensive care unit.
  
  
  METHODS
  Twenty-four patients with acute respiratory distress syndrome having P/F between 100 and 200 mm Hg at FIO2 0.5 received low-volume controlled ventilation (V(T) = 6 mL/kg predicted body weight) with a positive end-expiratory pressure at 2 cm H2O above the lower inflection point if present, or 10 cm H2O.
  
  
  METHODS
  The following FIO2 levels were applied randomly for 20 mins: 0.5, 0.6, 0.7, 0.8, 0.9, and 1.
  
  
  RESULTS
  Increasing FIO2 above 0.7 was associated with a significant increase in P/F (p < 0.001). The mean P/F change between FIO2 0.5 and 1 (Delta P/F) was 47% +/- 35%. Sixteen patients (67%) had a P/F >200 at FIO2 1 whereas P/F was <200 at FIO2 0.5. Venous admixture (Q(VA)/Q(T)) decreased linearly for each FIO2 step (p < 0.001). The Q(VA)/Q(T) change between FIO2 0.5 and 1 was strongly correlated with Delta P/F (r = 0.84). Delta P/F was higher in patients with true shunt <30% (64% [54-93]) than in those with shunt >30% (20% [10-36]; p = 0.003).
  
  
  CONCLUSIONS
  The P/F ratio increased significantly with a FIO2 >0.7. P/F variation, induced by a switch from FIO2 0.5 to 1, was responsible for two thirds of patients changing from the acute respiratory distress syndrome to the acute lung injury stage of the American-European Consensus Conference definition. FIO2 should be carefully defined for the screening of lung-injured patients.
authors.affiliation: Service de Réanimation Médicale, Hôpital Sainte Marguerite, 270 Boulevard Sainte Marguerite, 13274 Marseille Cedex 9, France. jerome.allardet-servent@mail.ap-hm.fr
authors.forename: Jérôme
authors.initials: J
authors.lastname: Allardet-Servent
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Forel
authors.forename: Antoine
authors.initials: A
authors.lastname: Roch
authors.forename: Christophe
authors.initials: C
authors.lastname: Guervilly
authors.forename: Laurent
authors.initials: L
authors.lastname: Chiche
authors.forename: Matthias
authors.initials: M
authors.lastname: Castanier
authors.forename: Nathalie
authors.initials: N
authors.lastname: Embriaco
authors.forename: Marc
authors.initials: M
authors.lastname: Gainnier
authors.forename: Laurent
authors.initials: L
authors.lastname: Papazian
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000502:physiology; D011446:Prospective Studies; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome / Q000145:classification / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D012129:Respiratory Function Tests
chemical_list: D010100:Oxygen