Prognostic value of circulating chromogranin A levels in acute coronary syndromes.
OBJECTIVE
To determine whether circulating levels of chromogranin A (CgA) provide prognostic information independently of conventional risk markers in acute coronary syndromes (ACSs).


RESULTS
We measured circulating CgA levels on day 1 in 1268 patients (median age 67 years, 70% male) with ACS admitted to a single coronary care unit of a Scandinavian teaching hospital. The merit of CgA as a biomarker was evaluated after adjusting for conventional cardiovascular risk factors. During a median follow-up of 92 months, 389 patients (31%) died. The baseline CgA concentration was strongly associated with increased long-term mortality [hazard ratio per 1 standard deviation increase in logarithmically transformed CgA level: 1.57 (1.44-1.70), P < 0.001], heart failure hospitalizations [1.54 (1.35-1.76), P < 0.001], and recurrent myocardial infarction (MI) [1.27 (1.10-1.47), P < 0.001], but not stroke. After adjustment for conventional cardiovascular risk markers, the association remained significant for mortality [hazard ratio 1.28 (1.15-1.42), P < 0.001] and heart failure hospitalization [hazard ratio 1.24 (1.04-1.47), P = 0.02], but not recurrent MI.


CONCLUSIONS
CgA is an independent predictor of long-term mortality and heart failure hospitalizations across the spectrum of ACSs and provides incremental prognostic information to conventional cardiovascular risk markers.
Jansson
Anna M
AM
Department of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Røsjø
Helge
H
Omland
Torbjørn
T
Karlsson
Thomas
T
Hartford
Marianne
M
Flyvbjerg
Allan
A
Caidahl
Kenneth
K
D054058:Acute Coronary Syndrome / Q000097:blood* / Q000000981:diagnostic imaging / Q000401:mortality; D000368:Aged; D015415:Biomarkers / Q000097:blood; D053379:Chromogranin A / Q000097:blood*; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies
D015415:Biomarkers; D053379:Chromogranin A; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain