title: Asymmetric organocatalytic Michael addition of ketones to vinyl sulfone.
abstract: Highly enantioselective organocatalytic Michael addition of ketones to vinyl sulfone catalyzed by a cinchona alkaloid-derived primary amine is reported for the first time; the described synthetic methodology was applied to the synthesis of sodium cyclamate.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543, Republic of Singapore.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhu
authors.forename: Lili
authors.initials: L
authors.lastname: Cheng
authors.forename: Yixin
authors.initials: Y
authors.lastname: Lu
mesh_terms: D002384:Catalysis; D003494:Cyclamates / Q000138:chemical synthesis / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D013450:Sulfones / Q000737:chemistry*
chemical_list: D003494:Cyclamates; D007659:Ketones; D013450:Sulfones; C009873:divinyl sulfone