Two new adjacent bis-tetrahydrofuran annonaceous acetogenins from seeds of Annona cornifolia.
Two new adjacent bis-THF annonaceous acetogenins, 9-hydroxyfolianin (1) and folianin B (2), together with two known acetogenins, asimicin (3) and bullatacin (4), significantly bioactives in brine shrimp lethality test, were isolated from seeds of Annona cornifolia A. St. Hil (Annonaceae). Their structures were elucidated by NMR and ESI-MS analysis, and relative configurations were established. The absolute configuration around the THF rings of 1 was defined by Mosher esters methodology and circular dichroism.
Rodrigues dos  Santos Lima
Luciana Alves
LA
Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Santos Pimenta
Lúcia Pinheiro
LP
Diamantino Boaventura
Maria Amélia
MA
D054378:Acetogenins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D031041:Annona / Q000737:chemistry*; D001156:Artemia / Q000187:drug effects; D005663:Furans / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D007928:Lethal Dose 50; D019906:Nuclear Magnetic Resonance, Biomolecular; D012639:Seeds / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
C539962:9-hydroxyfolianin; D054378:Acetogenins; D005663:Furans; C539963:folianin B; C061022:bullatacin