Injectable bioactive calcium-magnesium phosphate cement for bone regeneration.
Novel injectable and degradable calcium-magnesium phosphate cement (CMPC) with rapid-setting characteristic was developed by the introduction of magnesium phosphate cement (MPC) into calcium phosphate cement (CPC). The calcium-magnesium phosphate cement prepared under the optimum P/L ratio exhibited good injectability and desired workability. It could set within 10 min at 37 degrees C in 100% relative humidity and the compressive strength could reach 47 MPa after setting for 48 h, indicating that the prepared cement has relatively high initial mechanical strength. The results of in vitro degradation experiments demonstrated the good degradability of the injectable CMPC, and its degradation rate occurred significantly faster than that of pure CPC in simulated body fluid (SBF) solution. It can be concluded that the novel injectable calcium-magnesium phosphate cement is highly promising for a wide variety of clinical applications, especially for the development of minimally invasive techniques.
Wu
Fan
F
Key Laboratory for Ultrafine Materials of Ministry of Education, and Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, People's Republic of China.
Su
Jiacan
J
Wei
Jie
J
Guo
Han
H
Liu
Changsheng
C
D001826:Body Fluids / Q000737:chemistry; D001843:Bone Cements / Q000737:chemistry* / Q000494:pharmacology; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000737:chemistry; D002130:Calcium Phosphates / Q000008:administration & dosage*; D019245:Compressive Strength; D006863:Hydrogen-Ion Concentration; D007477:Ions; D017616:Magnesium Compounds / Q000008:administration & dosage*; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D010710:Phosphates / Q000008:administration & dosage*; D011312:Pressure; D013314:Stress, Mechanical; D013997:Time Factors; D014961:X-Ray Diffraction
D001843:Bone Cements; D018786:Bone Substitutes; D002130:Calcium Phosphates; D007477:Ions; D017616:Magnesium Compounds; D010710:Phosphates; C030781:magnesium phosphate; C020243:calcium phosphate