Toxicology of nanoparticles.
The paper considers the basic directions in fundamental and applied studies of the toxic effects of nanoparticles. Of particular importance is the study aimed at evaluation of the dependence of these effects on the shape, size, initial material, surface area, electric charge, and other physicochemical structural peculiarities, as well as on the dosage, mode of application, concentration in the target organ, and duration of action. The differences are stressed in the realization of general toxicity and genotoxicity of nanoparticles and chemical agents. The importance of the development of new methods of preclinical assessment of the safety of therapeutic nanoderivatives is emphasized.
Durnev
A D
AD
V. V. Zakusov State Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow. adurnev@aport.ru
D003257:Consumer Product Safety; D006801:Humans; D050997:Nanomedicine; D053758:Nanoparticles / Q000633:toxicity*; D010316:Particle Size; D018570:Risk Assessment