title: Protein tyrosine phosphatase gene C1858T allele confers risk for rheumatoid arthritis in Hungarian subjects.
abstract: The C1858T allele of the PTPN22 gene has been reported to confer risk for RA; but in some reports, the effect was restricted to RF- and/or anti-CCP-seropositive patients. Hungarian RA patients and matched controls were genotyped. The 1858T allele showed an increased prevalence in RA patients compared to controls. The 1858T allele represents a risk factor in the whole RA population (P = 0.001); an association was found both in RF-seropositive (P = 0.001) and anti-CCP-seropositive patients (P = 0.001), and in subjects with the combination of these factors (P = 0.002). In TT homozygotes, the estimated susceptibility to RA was more than double (OR = 5.04) of that seen in TC heterozygotes (OR = 1.89); the same gene dosage effect was observed in all seropositive RA subgroups. Our data show that the Hungarian RA patients belong to the populations in which the 1858T allele represents a susceptibility factor both in the RF- and/or anti-CCP-seropositive subjects, and the association exhibit a gene dosage dependency.
authors.affiliation: Department of Medical Genetics and Child Development, University of Pécs, Szigeti ut 12, 7624, Pecs, Hungary.
authors.forename: Bernadett
authors.initials: B
authors.lastname: Farago
authors.forename: Gabor C
authors.initials: GC
authors.lastname: Talian
authors.forename: Katalin
authors.initials: K
authors.lastname: Komlosi
authors.forename: Gergely
authors.initials: G
authors.lastname: Nagy
authors.forename: Timea
authors.initials: T
authors.lastname: Berki
authors.forename: Agnes
authors.initials: A
authors.lastname: Gyetvai
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Szekanecz
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Nyarady
authors.forename: Csaba G
authors.initials: CG
authors.lastname: Kiss
authors.forename: Peter
authors.initials: P
authors.lastname: Nemeth
authors.forename: Laszlo
authors.initials: L
authors.lastname: Czirjak
authors.forename: Bela
authors.initials: B
authors.lastname: Melegh
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000201:enzymology* / Q000208:ethnology / Q000235:genetics*; D004252:DNA Mutational Analysis; D005260:Female; D018628:Gene Dosage / Q000235:genetics; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006720:Homozygote; D006801:Humans; D006814:Hungary / Q000208:ethnology; D008213:Lymphocyte Activation / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22 / Q000235:genetics*; D012217:Rheumatoid Factor / Q000235:genetics; D017678:Sex Distribution; D013601:T-Lymphocytes / Q000201:enzymology
chemical_list: D005819:Genetic Markers; D012217:Rheumatoid Factor; C516765:PTPN22 protein, human; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22