title: Metastatic CNS lymphoma presenting with periventricular dissemination - MRI and neuropathological findings in an autopsy case.
abstract: Metastatic CNS lymphoma usually manifests as pachymeningeal or leptomeningeal infiltrates, and periventricular dissemination is rare. A 70-year old man first noticed a mass in the left supraclavicular fossa, and then presented with bilateral parkinsonism, followed by consciousness disturbance. Fluid attenuated inversion recovery (FLAIR) image of brain MRI demonstrated hyperintensities at the parenchyma around the lateral ventricle, third ventricle, and fourth ventricle. Gadolinium-enhanced T1-weighted image demonstrated enhancement along the whole wall of the ventricle. Biopsy of the left supraclavicular lymph nodes established a diagnosis of diffuse large B-cell lymphoma. The patient died of multiple organ failure about 5 months after the onset. Autopsy disclosed periventricular dissemination of lymphoma cells that was most severe around the lateral ventricle. We considered that the lymphoma cells entered the ventricular system through the choroid plexus of the lateral ventricle, followed by dissemination of the periventricular parenchyma.
authors.affiliation: Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Tokyo, 113-8519, Japan. zen@bg7.so-net.ne.jp
authors.forename: Zen
authors.initials: Z
authors.lastname: Kobayashi
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Tsuchiya
authors.forename: Akira
authors.initials: A
authors.lastname: Machida
authors.forename: Jun
authors.initials: J
authors.lastname: Goto
authors.forename: Osamu
authors.initials: O
authors.lastname: Yokota
authors.forename: Hirotomo
authors.initials: H
authors.lastname: Miake
authors.forename: Sadakiyo
authors.initials: S
authors.lastname: Watabiki
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Taki
authors.forename: Hideki
authors.initials: H
authors.lastname: Ishizu
authors.forename: Chie
authors.initials: C
authors.lastname: Haga
authors.forename: Tetsuaki
authors.initials: T
authors.lastname: Arai
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Akiyama
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Mizusawa
mesh_terms: D000368:Aged; D001706:Biopsy; D016545:Choroid Plexus Neoplasms / Q000473:pathology*; D017809:Fatal Outcome; D006801:Humans; D020547:Lateral Ventricles / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009362:Neoplasm Metastasis