title: Association between carotid and coronary artery disease in patients with aortic valve stenosis: an angiographic study.
abstract: BACKGROUND
  Patients with aortic stenosis have a high prevalence of coronary artery disease, but there is little information about the association of coronary artery disease and carotid artery disease.
  
  
  METHODS
  The study includes 317 consecutive patients with aortic stenosis, who underwent carotid and coronary angiography during the same catheterization before aortic valve replacement.
  
  
  RESULTS
  At univariate analysis, the prevalence of coronary artery disease was associated with (1) presence of carotid artery disease (P < .001); (2) angina pectoris as presentation symptom (P < .001); (3) age more than 65 years (P < .05); and (4) hypertension (P < .05). At multivariate analysis, only carotid artery disease, angina, and age emerged as independent predictors of coronary artery disease. The combination of 2 variables (carotid artery disease, angina) allowed the identification of 4 groups, with decreasing prevalence of coronary artery disease: (1) angina+/carotid artery disease+: 85%; (2) angina-/ carotid artery disease+: 50%; (3) angina+/carotid artery disease-: 41%; (4) angina-/carotid artery disease-: 21% (P < .001).
  
  
  CONCLUSIONS
  In patients with symptomatic aortic stenosis, the presence of significant carotid artery disease is a strong marker of significant coronary artery disease.
authors.affiliation: Cardiologia, ARC, Azienda Ospedaliera S. Maria degli Angeli, Pordenone, Italy. cardiologia@aopn.fvg.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Antonini-Canterin
authors.forename: Elisa
authors.initials: E
authors.lastname: Leiballi
authors.forename: Michele
authors.initials: M
authors.lastname: Capanna
authors.forename: Claudio
authors.initials: C
authors.lastname: Burelli
authors.forename: Matteo
authors.initials: M
authors.lastname: Cassin
authors.forename: Franco
authors.initials: F
authors.lastname: Macor
authors.forename: Umberto
authors.initials: U
authors.lastname: Grandis
authors.forename: Gian Luigi
authors.initials: GL
authors.lastname: Nicolosi
mesh_terms: D000367:Age Factors; D000368:Aged; D000787:Angina Pectoris / Q000209:etiology; D001024:Aortic Valve Stenosis / Q000150:complications / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000601:surgery; D002340:Carotid Artery Diseases / Q000150:complications / Q000000981:diagnostic imaging* / Q000453:epidemiology; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging* / Q000453:epidemiology; D005260:Female; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D015995:Prevalence; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors