title: Cervical tumor caused by the sexually mature stage of Fasciola hepatica.
abstract: A 58-year-old man presented with an asymptomatic 5cm left anterior cervical tumor that had been present for over a year. Histological analysis revealed chronic inflammation and granuloma with giant cells surrounding Fasciola hepatica eggs. Fas2 antigen was detected in the tissue by immunohistochemistry. Serology for F. hepatica was positive, but stool examinations were negative and eosinophil count was normal. A month later, the tumor recurred, and an adult parasite was found during excision. The patient received triclabendazole, and after 6 months serology was negative. Erratic localization of F. hepatica reveals a pathology involving chronic inflammation caused by a sexually mature parasite, although according to theory only immature parasites are located in ectopic lesions.
authors.affiliation: Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Av. Honorio Delgado 430, Urb. Ingeniería, San Martín de Porres AP 4314, Lima 100, Perú. luis.a.marcos@uth.tmc.edu
authors.forename: Luis A
authors.initials: LA
authors.lastname: Marcos
authors.forename: Pedro
authors.initials: P
authors.lastname: Légua
authors.forename: Juvenal
authors.initials: J
authors.lastname: Sánchez
authors.forename: José R
authors.initials: JR
authors.lastname: Espinoza
authors.forename: Pedro
authors.initials: P
authors.lastname: Yi
authors.forename: Manuel
authors.initials: M
authors.lastname: Tantaleán
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use; D000947:Antigens, Helminth / Q000032:analysis; D001562:Benzimidazoles / Q000627:therapeutic use; D003546:Cysteine Endopeptidases / Q000032:analysis; D003937:Diagnosis, Differential; D005210:Fasciola hepatica / Q000302:isolation & purification*; D005211:Fascioliasis / Q000175:diagnosis* / Q000188:drug therapy; D006099:Granuloma / Q000175:diagnosis / Q000469:parasitology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009333:Neck; D010270:Parasite Egg Count; D016896:Treatment Outcome; D000077682:Triclabendazole
chemical_list: D000871:Anthelmintics; D000947:Antigens, Helminth; D001562:Benzimidazoles; D000077682:Triclabendazole; D003546:Cysteine Endopeptidases; C507847:Fas2 antigen, Fasciola hepatica