title: Synthesis and biological evaluation of amide derivatives of diflunisal as potential anti-inflammatory agents.
abstract: To improve the medicinal activity, the structure of diflunisal has been modified. Twenty-one amide derivatives of diflunisal were synthesized starting from diflunisal in three steps with total yields from 72% to 89%. All compounds were identified by (1)H NMR, MS, and elemental analysis. The anti-inflammatory and analgesic activities for 19 compounds were evaluated. It was found that 5m possesses an excellent anti-inflammatory activity and a good analgesic activity, maybe a potential anti-inflammatory agent.
authors.affiliation: College of Pharmaceutical Science, Zhejiang University of Technology, 18, Chaowang Road, Hangzhou, Zhejiang 310032, China. drzhonggx@sohu.com
authors.forename: Guang-Xiang
authors.initials: GX
authors.lastname: Zhong
authors.forename: Jin-Qing
authors.initials: JQ
authors.lastname: Hu
authors.forename: Kun
authors.initials: K
authors.lastname: Zhao
authors.forename: Lu-Lu
authors.initials: LL
authors.lastname: Chen
authors.forename: Wei-Xiao
authors.initials: WX
authors.lastname: Hu
authors.forename: Ming-You
authors.initials: MY
authors.lastname: Qiu
mesh_terms: D000577:Amides / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004061:Diflunisal / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry
chemical_list: D000577:Amides; D000893:Anti-Inflammatory Agents; D004061:Diflunisal