title: The adsorption of biological peptides and proteins at the oil/water interface. A potentially important but largely unexplored field.
abstract: This review focuses on some new techniques to study the behavior of peptides and proteins bound to oil droplets. We will show how model peptides e.g., amphipathic alpha helices (AalphaH) and amphipathic beta strand (AbetaS) and some apolipoproteins adsorb to triacylglycerol (TAG) droplets and how they behave once adsorbed to the interface. While most of the studies described involve peptides and proteins at an oil/water interface, studies can also be carried out when the surface has been partially covered with phospholipids. This work is important because it examines biophysical changes that take place at lipid droplet interfaces and how this may relate to the metabolism of lipoproteins and lipid droplets.
authors.affiliation: Department of Physiology and Biophysics, Boston University School of Medicine, 700 Albany Street, W-302, Boston, MA 02118, USA. dmsmall@bu.edu
authors.forename: Donald M
authors.initials: DM
authors.lastname: Small
authors.forename: Libo
authors.initials: L
authors.lastname: Wang
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Mitsche
mesh_terms: D000327:Adsorption; D000818:Animals; D006801:Humans; D009821:Oils / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D009821:Oils; D010455:Peptides; D011506:Proteins; D014867:Water