title: Donovanosis with auto-amputation of penis in a HIV-2 infected person.
abstract: Donovanosis is a slowly progressive, granulomatous ulcerative disease , caused by Klebsiella (Calymmatobacterium) granulomatis. The disease is known to persist for years together, leading to complications. A male patient aged 30 years with underlying HIV-2 infection presented to the department of STD with painful ulceration over the genital region of 5 months duration, with absence of penis. Tissue smear from the ulcer and histopathological examination revealed large histiocytes with intracellular Donovan bodies (Pund cell). A final diagnosis of donovanosis with auto-amputation of penis with HIV-2 infection was made. The old conventional medicines, viz. streptomycin, doxycycline and amoxycillin, were effective. Though HIV-2 infections are milder than HIV-1 infections in all aspects, donovanosis in this HIV-2 infected case presented with complications. However, since the CD4 count was 748 cells/cmm, the severity is attributed to the long standing nature and negligence by the patient, and not to possible immunodeficiency.
authors.affiliation: Department of STD, Rangaraya Medical College, Government General Hospital, Kakinada, Andhra Pradesh, India. drchandragupta_ts@rediffmail.com
authors.forename: T S
authors.initials: TS
authors.lastname: Chandra Gupta
authors.forename: Thrimurthulu
authors.initials: T
authors.lastname: Rayudu
authors.forename: Srinivasa V
authors.initials: SV
authors.lastname: Murthy
mesh_terms: D000328:Adult; D000673:Amputation, Traumatic / Q000150:complications / Q000175:diagnosis*; D006100:Granuloma Inguinale / Q000150:complications / Q000175:diagnosis*; D015658:HIV Infections / Q000150:complications / Q000175:diagnosis*; D015498:HIV-2; D006801:Humans; D008297:Male; D010413:Penis / Q000293:injuries* / Q000821:virology