title: Severe optic neuropathy caused by dichloromethane inhalation.
abstract: OBJECTIVE
  In this paper, we report a case of severe optic neuropathy caused by dichloromethane inhalation.
  
  
  METHODS
  A 65-year-old man fell unconsciousness while cleaning a dichloromethane tank containing a small amount of dichloromethane (purity greater than 99%) and was transported to the emergency department of our hospital, after which he was treated with hyperbaric oxygen therapy. After 1 month, narrowing of the visual field in both eyes was noted and the patient was referred to our department for additional examinations. Visual acuity was 0.3 in both eyes, which demonstrated normal reactions to light, while the critical flicker frequency (CFF) values were 30 and 25 Hz in the right and left eye, respectively. There were no abnormal findings shown in slit-lamp and fundus examinations, except for a mild cataract. Concentric contractions of the visual field by 10 degrees in both eyes were shown by a Goldmann perimetry examination, while an electroretinogram (ERG) and visual evoked cortical potential (VECP) examination exhibited nearly normal results. We diagnosed the condition as optic neuropathy caused by organic solvent poisoning, based on the decreased visual acuity, decreased CFF values, and visual-field narrowing. Although the patient was treated with vitamin B(12), visual disturbance, optic nerve atrophy, and results of VECP examinations worsened in both eyes, whereas ERG examination results were normal.
  
  
  CONCLUSIONS
  Based on our findings, we considered that the central nervous system, including the optic nerve, was more severely damaged than the retina due to the normal findings in the ocular fundus and ERG examinations. Since dichloromethane produces carbon monoxide when catabolized in the liver, carbon monoxide toxicity together with the direct toxic effect of dichloromethane were considered to contribute to optic neuropathy in this case. The outcome for the present patient was poor.
authors.affiliation: Department of Ophthalmology, Kansai Medical University, Moriguchi, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kobayashi
authors.forename: Akira
authors.initials: A
authors.lastname: Ando
authors.forename: Nobuko
authors.initials: N
authors.lastname: Tagami
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kitagawa
authors.forename: Emi
authors.initials: E
authors.lastname: Kawai
authors.forename: Masako
authors.initials: M
authors.lastname: Akioka
authors.forename: Eiko
authors.initials: E
authors.lastname: Arai
authors.forename: Toshio
authors.initials: T
authors.lastname: Nakatani
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nakano
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Matsui
authors.forename: Miyo
authors.initials: M
authors.lastname: Matsumura
mesh_terms: D000368:Aged; D006801:Humans; D019570:Inhalation Exposure; D008297:Male; D008752:Methylene Chloride / Q000506:poisoning*; D009901:Optic Nerve Diseases / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D008752:Methylene Chloride