Chaetoglobins A and B, two unusual alkaloids from endophytic Chaetomium globosum culture.
Chaetoglobins A (1) and B (2), two azaphilone alkaloid dimers with an unprecedented skeleton, were characterized from an endophytic fungus Chaetomium globosum with the former ascertained to be a significant cytotoxin valuable for anti-tumor drug discovery.
Ming Ge
Hui
H
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093, PR China.
Yun Zhang
Wei
W
Ding
Gang
G
Saparpakorn
Patchareenart
P
Chun Song
Yong
Y
Hannongbua
Supa
S
Tan
Ren Xiang
RX
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002597:Chaetomium / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D007546:Isoquinolines / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D010860:Pigments, Biological / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000470:Alkaloids; D000970:Antineoplastic Agents; D001578:Benzopyrans; D007546:Isoquinolines; D010860:Pigments, Biological; C494154:azaphilone; C534395:chaetoglobin A; C534396:chaetoglobin B