Complete switch of product selectivity in asymmetric direct aldol reaction with two different chiral organocatalysts from a common chiral source.
A novel approach for asymmetric synthesis of both enantiomeric aldol products has been developed by designing two different chiral organocatalysts from a readily available, protected cis-diamine compound as a common chiral source. This approach would be very useful from a practical viewpoint.
Nakayama
Keiji
K
Process Technology Research Laboratories, Daiichi Sankyo Co., LTD, Hiratsuka, Kanagawa 254-0014, Japan.
Maruoka
Keiji
K