Human leukocyte antigens (HLA) associated with selective IgA deficiency in Iran and Sweden.
Selective IgA deficiency (IgAD) (serum IgA concentration of <0.07 g/l) is the most common primary immunodeficiency in Caucasians, with an estimated prevalence of 1/600. There are strong indications for involvement of genetic factors in development of the disease and the frequency of several extended major histocompatibility complex haplotypes (including HLA-A1, B8, DR3, DQ2) have previously been shown to be increased among Caucasian patients with IgAD.PCR was used to type HLA B, DR, and DQ alleles in 29 Iranian individuals with IgAD and 299 Swedish individuals with IgAD.The results indicate a strong association with the HLA B14, DR1 alleles in Iranian subjects and HLA B8, B12, B13, B14, B40, DR1, DR3, DR7, DQ2 and DQ5 alleles in Swedish subjects.Differences in HLA association of IgAD in Iran and Sweden confirm the notion of a genetic background of the disease and that multiple, potentially different genes within the MHC region might be involved in the pathogenesis of IgAD in different ethnic groups.
Mohammadi
Javad
J
Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, SE-141 86 Stockholm, Sweden.
Pourpak
Zahra
Z
Jarefors
Sara
S
Saghafi
Shiva
S
Zendehdel
Kazem
K
Pourfathollah
Ali Akbar
AA
Amirzargar
Ali Akbar
AA
Aghamohammadi
Asghar
A
Moin
Mostafa
M
Hammarstrom
Lennart
L
D005787:Gene Frequency / Q000276:immunology; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000235:genetics* / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D017098:IgA Deficiency / Q000097:blood / Q000235:genetics* / Q000276:immunology; D007136:Immunoglobulins / Q000097:blood*; D007492:Iran; D011110:Polymorphism, Genetic; D013548:Sweden; D044465:White People
D006680:HLA Antigens; D007136:Immunoglobulins