Intraocular pressure in schizophrenic patients treated with psychiatric medications.
OBJECTIVE
In order to assess the occurrence of adverse ocular effects of antipsychotic drugs, we sought to evaluate intraocular pressure of schizophrenic patients treated with psychiatric medications.


METHODS
Twenty-eight outpatients with DSM-IV diagnosis of schizophrenia who met both the inclusion and exclusion criteria were submitted to an ophthalmic evaluation for ocular abnormalities which included intraocular pressure measurement with Goldmann applanation tonometry.


RESULTS
Raised intraocular pressure was found in three patients (11%). Abnormality in cup-disc ratio was seen in only one patient with cup-disc ratio asymmetry of 0.4. All these four patients were taking only ziprasidone.


CONCLUSIONS
Patients using ziprasidone were found to have abnormalities in both intraocular pressure and cup-disc ratio.
Souza
Valéria Barreto Novais E
VB
Universidade Federal do Ceará, Fortaleza, CE, Brasil. valbns@yahoo.com.br
Moura Filho
Francisco José Rodrigues de
FJ
Souza
Fábio Gomes de Matos E
FG
Pereira Filho
Sergio Augusto Carvalho
SA
Coelho
Suele Serra
SS
Furtado
Fernando Antônio Mendes Lopes
FA
Gonçalves
Tiago Bessa Almeida
TB
Vasconcelos
Karla Feitosa Ximenes
KF
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000188:drug therapy*; D014065:Tonometry, Ocular; D055815:Young Adult
D014150:Antipsychotic Agents