title: Intrapancreatic schwannoma diagnosed by endoscopic ultrasound-guided fine-needle aspiration cytology.
abstract: Schwannoma is a tumor of neuro-ectodermal origin, usually occuring in the head and neck and extremities. A retroperitoneal, and particularly intra-pancreatic presentation is very rare, and poses a clinical and diagnostic challenge. We report a case of a male patient who underwent an Endoscopic Ultrasound-guided Fine Needle Aspiration (EUS-FNA) biopsy of a hypoechoic, intra-pancreatic mass. The onsite cytological evaluation was consistent with a spindle cell neoplasm. Further evaluation, aided by immunohistochemical stains, defined the mass as a Schwannoma. The patient then underwent a pancreaticoduodenectomy and the histopathological diagnosis of the surgical specimen confirmed the cytological diagnosis. To our knowledge, this is the first report of intra-pancreatic Schwannoma diagnosed preoperatively by EUS-FNA cytology.
authors.affiliation: Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
authors.forename: Shaoying
authors.initials: S
authors.lastname: Li
authors.forename: Syed Z
authors.initials: SZ
authors.lastname: Ai
authors.forename: Christopher
authors.initials: C
authors.lastname: Owens
authors.forename: Peter
authors.initials: P
authors.lastname: Kulesza
mesh_terms: D000328:Adult; D044963:Biopsy, Fine-Needle / Q000379:methods; D024141:Collagen Type IV / Q000378:metabolism; D004724:Endoscopy; D006801:Humans; D008297:Male; D009442:Neurilemmoma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism; D009418:S100 Proteins / Q000378:metabolism; D014463:Ultrasonography
chemical_list: D024141:Collagen Type IV; D009418:S100 Proteins; D019009:Proto-Oncogene Proteins c-kit