title: Interstitial deletion of the distal long arm of chromosome 4, del (4)(q33-q35), in association with paternal balanced translocation.
abstract: Interstitial deletions of the long arm of chromosome 4 are rare. The deletions may occur at the proximal or the distal portions of the chromosome and different breakpoints may be involved. We report an interstitial deletion of 4q: 46XY der 4 (q28;q35) in a six-year-old boy with dysmorphic features associated with moderate mental retardation. Parental chromosomal analysis showed a balanced paternal translocation.
authors.affiliation: Department of Pathology, Faculty of Medicine, Hospital Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, Kuala Lumpur, Malaysia. ayureena@hotmail.com
authors.forename: R
authors.initials: R
authors.lastname: Mdzin
authors.forename: C
authors.initials: C
authors.lastname: Ko
authors.forename: Z
authors.initials: Z
authors.lastname: Abdul Latif
authors.forename: Z
authors.initials: Z
authors.lastname: Zakaria
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics; D001827:Body Height; D002648:Child; D002871:Chromosome Banding; D002872:Chromosome Deletion; D025063:Chromosome Disorders / Q000235:genetics; D002894:Chromosomes, Human, Pair 4; D005220:Fathers; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008607:Intellectual Disability / Q000235:genetics; D007621:Karyotyping; D008297:Male; D014178:Translocation, Genetic