Shortening the immunodeficient period after hematopoietic stem cell transplantation.
The delayed reconstitution of the T-lymphoid compartment represents a major clinical challenge after HLA-mismatched hematopoietic stem cell transplantation. The generation of new T lymphocytes deriving from transplanted hematopoietic stem cells requires several months, a period associated with an increased risk of opportunistic infections and relapses. Recently, the early steps of human lymphopoiesis and the nature of the thymus-seeding progenitors were described. Moreover several scientific groups succeeded to generate T-cell precursors from murine and human hematopoietic stem cells in vitro by transitory exposition to Notch-ligands. Here we summarize and discuss these results and their possible usage in the development of new cell therapies to shorten the immunodeficient period following hematopoietic stem cell transplantation.
André-Schmutz
Isabelle
I
INSERM, U768, Paris, 75015, France. isabelle.andre-schmutz@inserm.fr
Six
Emmanuelle
E
Bonhomme
Delphine
D
Rouiller
Julien
J
Dal Cortivo
Liliane
L
Fischer
Alain
A
Cavazzana-Calvo
Marina
M
D000818:Animals; D001854:Bone Marrow Cells / Q000276:immunology / Q000378:metabolism; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006412:Hematopoietic Stem Cells / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000209:etiology* / Q000628:therapy*; D016219:Immunotherapy, Adoptive; D038041:Lymphopoiesis; D051379:Mice; D054504:Precursor Cells, T-Lymphoid / Q000276:immunology* / Q000378:metabolism; D051880:Receptors, Notch / Q000276:immunology / Q000378:metabolism
D051880:Receptors, Notch