Mosaic cri-du-chat syndrome in a girl with a mild phenotype.
We report on the clinical observation of a girl patient with few signs of cri-du-chat syndrome. The chromosomal analysis in lymphocyte culture showed 46,XX,del(5)(p15.3) in 38% of cells. Psychological tests revealed motor, perceptive and visual-spatial problems, as well as immaturity and emotional dependence. The phoniatric evaluation showed poor vocabulary, difficulty with repeating words or numbers in sequence, and better receptive than expressive language. The spectrographic measurements showed disturbance of fundamental frequency (F0) in vocal pronunciation. The anatomic findings of the laryngoscopic evaluation were normal, indicating that the voice and speech problems were functional disorders. The present case revealed moderate clinical signs and vocal disturbance associated with a low percentage of 5p- cells and the breakpoint at 5p15.3. The short terminal deletion with a possible loss of the critical region for cat-like cry and the presence of a normal cell line, explain the cry not so typical at birth (weak but not high-pitched), the intermediate values of F0, and the moderate mental retardation. This case is compared with other mosaic 5p- patients reported in the literature.
Moreira
Lilia Maria de Azevedo
LM
Laboratory of Human Genetics and Mutagenesis, Biology Institute, Federal University of Bahia (UFBA)-Campus Universitário de Ondina, Salvador, Bahia, Brazil. lazevedo@ufba.br
de Carvalho
Acácia Fernandes Lacerda
AF
Borja
Ana Lúcia Vieira de Freitas
AL
Pinto
Paula Sanders Pereira
PS
Silveira
Adriana
A
de Freitas
Lucy Magalhães
LM
Falcão
Maria de Lourdes Lima
Mde L
D002648:Child; D002872:Chromosome Deletion; D002895:Chromosomes, Human, Pair 5; D003410:Cri-du-Chat Syndrome / Q000235:genetics*; D002658:Developmental Disabilities / Q000235:genetics; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics; D007621:Karyotyping; D010641:Phenotype