title: A new twist on an old problem: a case of pediatric meningitis caused by multidrug-resistant Streptococcus pneumoniae serotype 19A.
abstract: Recent studies show that multidrug-resistant Streptococcus pneumoniae serotype 19A continues to emerge as a cause of invasive pneumococcal disease after the introduction of Prevnar. We report a case of multidrug-resistant S. pneumoniae serotype 19A meningitis successfully treated with vancomycin and levofloxacin. This case reinforces the need for the empiric use of vancomycin in meningitis and the need for alternative treatments.
authors.affiliation: Department of Infectious Diseases and Medical Microbiology, McMaster University, Hamilton, Ontario, Canada.
authors.forename: W
authors.initials: W
authors.lastname: Ciccotelli
authors.forename: S
authors.initials: S
authors.lastname: Poutanen
authors.forename: S
authors.initials: S
authors.lastname: Morris
authors.forename: M
authors.initials: M
authors.lastname: Alqahtani
authors.forename: P
authors.initials: P
authors.lastname: Cox
authors.forename: D
authors.initials: D
authors.lastname: Low
authors.forename: D
authors.initials: D
authors.lastname: Pillai
authors.forename: M
authors.initials: M
authors.lastname: Opavsky
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002444:Cefuroxime / Q000627:therapeutic use; D024901:Drug Resistance, Multiple, Bacterial; D004359:Drug Therapy, Combination; D006801:Humans; D007223:Infant; D064704:Levofloxacin; D008586:Meningitis, Pneumococcal / Q000175:diagnosis / Q000188:drug therapy*; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000627:therapeutic use; D013296:Streptococcus pneumoniae; D014640:Vancomycin / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D064704:Levofloxacin; D014640:Vancomycin; D015242:Ofloxacin; D002444:Cefuroxime