[Anticonvulsant induced metabolic disorder--case report].
Osteomalacia, metabolic bone disease in the adults, is disorder in which mineralization of the organic matrix of the skeleton is defective. This disorder is caused by a number of different conditions associated with alterations of vitamin D metabolism. Anticonvulsant therapy can also cause the development of osteomalacia due to alteration of vitamin D metabolism inducing hepatic mycrosomal enzymes, inhibiting 25-hydroxilation of vitamin D. They also inhibit intestinal calcium transport and bone mineral mobilization, independent of effects on vitamin D metabolism. This paper presents a patient who was unable to walk due to anticonvulsants induced osteomalacia. Anticonvulsant use has been implicated as a cause of bone disease for more than 30 years but there is no official recommendation for calcium and vitamin D therapy in anticonvulsant treated individuals.
Kaliterma
Dusanka Martinović
DM
Odsjek za klinicku imunologiju i reumatologiju, Klinika za unutarnje bolesti, Klinicki bolnicki centar Split, Soltanska 1, Split. d.martinovic@inet.hr
Jurisić
Zrinka
Z
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D005260:Female; D006801:Humans; D010018:Osteomalacia / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011859:Radiography
D000927:Anticonvulsants