Ventricular fibrillation following autologous intramyocardial cell therapy for inherited cardiomyopathy.
A 41-year-old male with cardiomyopathy from an inherited beta myosin heavy-chain mutation underwent treatment for heart failure with intramyocardial cell transplantation. He received direct injections into his heart of autologous precursor cells isolated from his blood. He immediately suffered ventricular fibrillation. Although he was resuscitated, he experienced a prolonged downward course that prohibited his undergoing transplantation. His autopsy revealed marked fibrosis throughout the myocardium with areas of mononuclear cell infiltrate. This case highlights the potential adverse effects associated with intramyocardial therapy in the cardiomyopathic heart.
Pytel
Peter
P
Department of Pathology, The University of Chicago, Chicago, IL 60637, USA.
Husain
Aliya
A
Moskowitz
Ivan
I
Raman
Jai
J
MacLeod
Heather
H
Anderson
Allen S
AS
Burke
Martin
M
McNally
Elizabeth M
EM
D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D024722:Cardiac Myosins / Q000235:genetics / Q000378:metabolism; D024741:Cardiomyopathy, Hypertrophic, Familial / Q000235:genetics / Q000473:pathology / Q000601:surgery*; D017809:Fatal Outcome; D005355:Fibrosis / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D018995:Myosin Heavy Chains / Q000235:genetics / Q000378:metabolism; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D011183:Postoperative Complications / Q000209:etiology* / Q000473:pathology; D014182:Transplantation, Autologous; D014693:Ventricular Fibrillation / Q000209:etiology* / Q000473:pathology
D015703:Antigens, CD; D015415:Biomarkers; C501641:MYH7 protein, human; D024722:Cardiac Myosins; D018995:Myosin Heavy Chains