title: Ni/Ni oxides nanoparticles with potential biomedical applications obtained by displacement of a nickel-organometallic complex.
abstract: A new synthesis and stabilization method was developed for paramagnetic nanoparticles composed of nickel and nickel oxides. Nickel/nickel oxides nanoparticles were synthesized by a method based on ligand displacement of bis(1,5-cyclooctadiene)-nickel(0), zerovalent organometallic precursor and simultaneous formation of a thiourea inclusion compound. Nickel/nickel oxides nanoparticles were stabilized with the amphipathic peptide H2N-Cys-Leu-Pro-Phe-Phe-Asp-NH2 having H2N-Leu-Pro-Phe-Phe-Asp-NH2 a peptide with potential properties for Alzheimer's disease therapy. The inclusion compound formed after displacement was characterized by X-ray powder diffraction, and nickel/nickel oxides nanoparticles were characterized using transmission electron microscopy, atomic force microscopy, UV-Visible spectroscopy, X-ray photoelectron spectroscopy, and superconducting quantum interference device magnetometry. In addition, a cell viability assay in primary rat hippocampal neurons was carried out.
authors.affiliation: Departamento de Química, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile.
authors.forename: Saddys
authors.initials: S
authors.lastname: Rodríguez-Llamazares
authors.forename: Juan
authors.initials: J
authors.lastname: Merchán
authors.forename: Ivonne
authors.initials: I
authors.lastname: Olmedo
authors.forename: Héctor Pablo
authors.initials: HP
authors.lastname: Marambio
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Muñoz
authors.forename: Paul
authors.initials: P
authors.lastname: Jara
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Sturm
authors.forename: Boris
authors.initials: B
authors.lastname: Chornik
authors.forename: Octavio
authors.initials: O
authors.lastname: Peña
authors.forename: Nicolás
authors.initials: N
authors.lastname: Yutronic
authors.forename: Marcelo Javier
authors.initials: MJ
authors.lastname: Kogan
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D016503:Drug Delivery Systems; D004355:Drug Stability; D006624:Hippocampus / Q000166:cytology; D066298:In Vitro Techniques; D053768:Metal Nanoparticles / Q000737:chemistry*; D009474:Neurons / Q000166:cytology / Q000187:drug effects; D009532:Nickel / Q000737:chemistry*; D009842:Oligopeptides / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: C534619:H2N-Leu-Pro-Phe-Phe-Asp-NH2; D009842:Oligopeptides; D009532:Nickel; C028007:nickel monoxide