title: Regional admittivity spectra with tomosynthesis images for breast cancer detection: preliminary patient study.
abstract: It has been known for some time that many tumors have a significantly different conductivity and permittivity from surrounding normal tissue. This high "contrast" in tissue electrical properties, occurring between a few kilohertz and several megahertz, may permit differentiating malignant from benign tissues. Here we show the ability of electrical impedance spectroscopy (EIS) to roughly localize and clearly distinguish cancers from normal tissues and benign lesions. Localization of these lesions is confirmed by simultaneous, in register digital breast tomosynthesis (DBT) mammography or 3-D mammograms.
authors.affiliation: Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA. kaot@rpi.edu
authors.forename: Tzu-Jen
authors.initials: TJ
authors.lastname: Kao
authors.forename: Gregory
authors.initials: G
authors.lastname: Boverman
authors.forename: Bong Seok
authors.initials: BS
authors.lastname: Kim
authors.forename: David
authors.initials: D
authors.lastname: Isaacson
authors.forename: Gary J
authors.initials: GJ
authors.lastname: Saulnier
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Newell
authors.forename: Myoung H
authors.initials: MH
authors.lastname: Choi
authors.forename: Richard H
authors.initials: RH
authors.lastname: Moore
authors.forename: Daniel B
authors.initials: DB
authors.lastname: Kopans
mesh_terms: D000465:Algorithms; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D017097:Electric Impedance; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation / Q000379:methods; D016014:Linear Models; D008327:Mammography / Q000295:instrumentation / Q000379:methods; D011237:Predictive Value of Tests; D011856:Radiographic Image Enhancement / Q000379:methods; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods; D014054:Tomography / Q000295:instrumentation / Q000379:methods