title: A pair of twins born after maternal exposure to leflunomide.
abstract: Leflunomide is a drug used in rheumatoid arthritis with teratogenic and fetotoxic effects. Clinical data on human pregnancies are limited to a few case reports without detailed information whether the mothers did have a washout procedure as suggested by the manufacturer or what type of malformation the offspring showed. We report on a set of twins born after maternal exposure to leflunomide who had a largely normal neonatal outcome, providing information about the washout procedure and the blood level of the active metabolite.
authors.affiliation: Department of Neonatology, University Children's Hospital, Tübingen, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Heine
authors.forename: C F
authors.initials: CF
authors.lastname: Poets
mesh_terms: D000328:Adult; D018501:Antirheumatic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005317:Fetal Growth Retardation; D006801:Humans; D007231:Infant, Newborn; D007555:Isoxazoles / Q000009:adverse effects* / Q000627:therapeutic use; D000077339:Leflunomide; D011225:Pre-Eclampsia; D011247:Pregnancy; D014430:Twins, Monozygotic
chemical_list: D018501:Antirheumatic Agents; D007555:Isoxazoles; D000077339:Leflunomide