Synthesis, crystal structure, antioxidant activities and DNA-binding studies of the Ln(III) complexes with 7-methoxychromone-3-carbaldehyde-(4'-hydroxy) benzoyl hydrazone.
A novel chromone Schiff base, 7-methoxychromone-3-carbaldehyde-(4'-hydroxy) benzoyl hydrazone (L) and its Ln(III) complexes (Ln = La, Eu) were synthesized and characterized. The crystal structure of the La(III) complex was determined by single-crystal X-ray diffraction: crystallized in the orthorhombic system, space group Pbcn, Z = 8, a = 14.595(2)A, b = 20.055(3)A, c = 30.078(5)A, R(1) = 0.0657. Fluorescence titration spectra, electronic absorption titration spectra, EB displacement and viscosity measurement indicated that both the ligand and the complexes can bind to DNA via the intercalation mode, and that the binding affinity of the La(III) complex is higher than that of the Eu(III) complex and of the ligand (L). The antioxidant activity experiments show that these compounds also exhibit good antioxidant activities against (*)OH and O(2)(-). Moreover, the Eu(III) complex exhibits characteristic fluorescence of europium ion in different organic solvents.
Wang
Qian
Q
College of Chemistry and Chemical Engineering and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China.
Yang
Zheng-Yin
ZY
Qi
Gao-Fei
GF
Qin
Dong-Dong
DD
D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001665:Binding Sites; D002417:Cattle; D002867:Chromones / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry*; D006835:Hydrazones / Q000737:chemistry*; D007811:Lanthanum / Q000737:chemistry*; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D012545:Schiff Bases / Q000737:chemistry
C541993:7-methoxychromone-3-carbaldehyde-(4'-hydroxy)benzoyl hydrazone; D000975:Antioxidants; D002867:Chromones; D006835:Hydrazones; D008024:Ligands; D009942:Organometallic Compounds; D012545:Schiff Bases; D007811:Lanthanum; D004247:DNA; C427203:calf thymus DNA