title: [Follow-up and management of Coats disease diagnosed in childhood].
abstract: OBJECTIVE
  To investigate retrospectively the clinical manifestation and the final visual prognosis through a long-term fellow-up study.
  
  
  METHODS
  It was retrospective case series study. Twenty four patients (26 eyes) were diagnosed with Coats disease from 1962 through 2006 at the Department of Ophthalmology, Peking Union Medical Hospital, Chinese Academy of Medical Sciences. Age, visual acuity, time of initial visit, method of treatment and the condition of eye fundus for each patient were documented. The time of follow-up ranged from 1-44 years, averaged 5 years.
  
  
  RESULTS
  Age of the patients at initial visit ranged between 1 to 18 years old, 7 years on average. Eighteen patients (75%) were male and 6 were female (25%). Twenty two cases were unilateral and only 2 female patients were bilateral. In 26 eyes, 7 eyes exhibited capillary irregular dilatation, miliary aneurysms and nonperfusion area on fluorescein angiography located at peripheral fundus; 15 eyes were complicated with exudative retinal detachment. Four eyes reached end stage with no light perception or only finger count. Laser photocoagulation was performed in 21 eyes. In 10 eyes, retinal exudates and hemorrhages were absorbed with improvement of visual acuity. Ten eyes with extensive retinal detachment including macula underwent closed vitrectomy, the best visual acuity was 0.1 after surgery.
  
  
  CONCLUSIONS
  The onset of Coats disease is in early young childhood. Abnormal vascular lesions and military aneurysms appeared at peripheral fundus with early retinal exudation involving the macula. Early treatment with laser coagulation could obtain good visual prognosis. The supplement treatment is required for new lesions occurring during the long- term follow-up period.
authors.affiliation: Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijng 100730, China. Zhangchengfen@yahoo.com.cn
authors.forename: Cheng-fen
authors.initials: CF
authors.lastname: Zhang
authors.forename: Fang-tian
authors.initials: FT
authors.lastname: Dong
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Bao-ling
authors.initials: BL
authors.lastname: Han
authors.forename: Hong
authors.initials: H
authors.lastname: Du
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D017075:Laser Coagulation; D008297:Male; D011379:Prognosis; D012164:Retinal Diseases / Q000175:diagnosis* / Q000601:surgery*; D012189:Retrospective Studies; D013684:Telangiectasis