PEG-immobilization of cardol and soluble polymer-supported synthesis of some cardol-coumarin derivatives: preliminary evaluation of their inhibitory activity on mushroom tyrosinase.
In this work, the PEG-immobilization and the liquid phase synthesis of some coumarins derived from cardol are presented. Some preliminary results on their tyrosinase inhibitory activity are also included.
Tocco
Graziella
G
Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Cagliari, Cagliari, CA, Italy. toccog@unica.it
Fais
Antonella
A
Meli
Gabriele
G
Begala
Michela
M
Podda
Gianni
G
Fadda
M Benedetta
MB
Corda
Marcella
M
Attanasi
Orazio A
OA
Filippone
Paolino
P
Berretta
Stefano
S
D000363:Agaricales / Q000201:enzymology*; D003374:Coumarins / Q000138:chemical synthesis* / Q000494:pharmacology*; D005656:Fungal Proteins; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D011092:Polyethylene Glycols; D011108:Polymers; D012118:Resorcinols / Q000737:chemistry*; D012995:Solubility
D003374:Coumarins; D005656:Fungal Proteins; D011108:Polymers; D012118:Resorcinols; D011092:Polyethylene Glycols; C030123:coumarin; D014442:Monophenol Monooxygenase; C041328:adipostatin A