Before they were fat: adipocyte progenitors.
Adipose tissue mass can expand throughout adult life. Therefore, proliferative adipocyte precursor cells must stand at the ready to respond to increased demand for energy storage. Recent provocative studies have identified discrete immature cell populations from which brown and white adipocytes are derived. This work not only brings fundamental insight into adipose tissue formation but also provides new tools to study how adipogenesis is regulated in pathological conditions such as obesity and diabetes.
Park
Kye Won
KW
Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095, USA.
Halperin
Daniel S
DS
Tontonoz
Peter
P
D017667:Adipocytes / Q000166:cytology*; D050156:Adipogenesis; D002001:Adipose Tissue, Brown / Q000166:cytology* / Q000254:growth & development / Q000378:metabolism; D052436:Adipose Tissue, White / Q000166:cytology* / Q000254:growth & development / Q000378:metabolism; D000818:Animals; D051927:CD24 Antigen / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D047495:PPAR gamma / Q000235:genetics / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D051927:CD24 Antigen; D047495:PPAR gamma; C406806:Tg(AZIP-F)1Vsn protein, mouse; D014157:Transcription Factors