title: An efficient and general enantioselective synthesis of sphingosine, phythosphingosine, and 4-substituted derivatives.
abstract: A general and efficient protocol for the enantioselective synthesis of sphingosine, phythosphingosine, and 4-substituted derivatives was established. These compounds were obtained from a common intermediate prepared from butadiene monoepoxide by a synthetic sequence involving enantioselective allylic substitution, cross-metathesis, and dihydroxylation.
authors.affiliation: Departament de Química Analítica i Química Orgànica, Facultat de Química, Universitat Rovira i Virgili, 43007 Tarragona, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Llaveria
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Díaz
authors.forename: M Isabel
authors.initials: MI
authors.lastname: Matheu
authors.forename: Sergio
authors.initials: S
authors.lastname: Castillón
mesh_terms: D006900:Hydroxylation; D015394:Molecular Structure; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D013110:Sphingosine