[Correlation between the expression of thrombospondin-1 and the angiogenesis in mucoepidermoid carcinoma].
OBJECTIVE
To study the relationship between the expression of thrombospondin-1 (TSP-1) and the angiogenesis in mucoepidermoid carcinoma.


METHODS
Immunohistochemistry were applied to detect the expression of TSP-1 and the value of microvessel density (MVD) in 45 mucoepidermoid carcinoma patients.


RESULTS
Positive expressions of TSP-1 protein were detected in 26 of the 45 (57. 78%) cases. Most positive staining for TSP-1 was observed in the cytoplasm of the cancer cells, some of those were in the extracellular matrix. The mean MVD in 45 cases with mucoepidermoid carcinoma was 60. 68 +/- 19.84 vessels per 100 field of vision. Tumors with a high expression of TSP-1 showed a low value of MVD and the correlation between TSP-1 immunocompetence and microvessel density was highly significant (r(s) = -0.942, P < 0.001).


CONCLUSIONS
The TSP-1 is expressed in most mucoepidermoid carcinoma and were associated with neovascularization. TSP-1 is likely to inhibit the extensive neovascularization and increased TSP-1 expression might inhibit angiogenic phenotype in mucoepidermoid carcinoma.
Yang
Sen
S
State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, China.
Tang
Xiu-fa
XF
Guo
Li-juan
LJ
Tan
Ke
K
Cao
Yu-tang
YT
Gong
Ren-guo
RG
Gao
Qing-hong
QH
Xuan
Ming
M
Wen
Yu-ming
YM
Wang
Chang-mei
CM
Wang
Xiao-yi
XY
D000328:Adult; D000368:Aged; D020533:Angiogenesis Inhibitors; D018277:Carcinoma, Mucoepidermoid / Q000098:blood supply / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000098:blood supply / Q000378:metabolism*; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D019700:Thrombospondin 1 / Q000096:biosynthesis*
D020533:Angiogenesis Inhibitors; D019700:Thrombospondin 1