title: Sesquiterpene lactones from Gonospermum gomerae and G. fruticosum and their cytotoxic activities.
abstract: Four new sesquiterpene lactones (1-4) and a new sesquiterpene (5) together with 20 known compounds were isolated from two Gonospermum species (G. gomerae Bolle and G. fruticosum Less). Their structures were determined by analysis of spectroscopic data, including 1D and 2D NMR. The cytotoxicity of several new and known natural and semisynthetic sesquiterpene lactones was also assessed against human myeloid leukemia cell lines (HL-60 and U937), human melanoma cells (SK-MEL-1), and human adenocarcinoma (A549).
authors.affiliation: Departamento de Química, Universidad de Las Palmas de Gran Canaria, Campus de Tafira, 35017 Las Palmas de Gran Canaria, Canary Islands, Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Triana
authors.forename: José Luis
authors.initials: JL
authors.lastname: Eiroa
authors.forename: Juan José
authors.initials: JJ
authors.lastname: Ortega
authors.forename: Francisco
authors.initials: F
authors.lastname: León
authors.forename: Ignacio
authors.initials: I
authors.lastname: Brouard
authors.forename: Fernando
authors.initials: F
authors.lastname: Torres
authors.forename: José
authors.initials: J
authors.lastname: Quintana
authors.forename: Francisco
authors.initials: F
authors.lastname: Estévez
authors.forename: Jaime
authors.initials: J
authors.lastname: Bermejo
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013030:Spain; D020298:U937 Cells
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; D012717:Sesquiterpenes