title: A promising anticancer and antimalarial component from the leaves of Bidens pilosa.
abstract: Bidens pilosa is used in folk medicine for various applications due to the presence of polyacetylenes, flavonoids, terpenoids, phenylpropanoids and others. Bioactivity-guided fractionation of different extracts of B. pilosa leaf showed potential in vitro anticancer and antimalarial activity and led to the identification of a potential marker compound, phenyl-1,3,5-heptatriyne. Erythrocyte osmotic fragility experiments revealed the various extracts as well as the marker component's toxicity profiles on normal blood cells.
authors.affiliation: Analytical Chemistry Division, Central Institute of Medicinal and Aromatic Plants (CIMAP), Council of Scientific and Industrial Research (CSIR), Lucknow, India.
authors.forename: Priyanka
authors.initials: P
authors.lastname: Kumari
authors.forename: Kanak
authors.initials: K
authors.lastname: Misra
authors.forename: Brijesh Singh
authors.initials: BS
authors.lastname: Sisodia
authors.forename: Uzma
authors.initials: U
authors.lastname: Faridi
authors.forename: Suchita
authors.initials: S
authors.lastname: Srivastava
authors.forename: Suiab
authors.initials: S
authors.lastname: Luqman
authors.forename: Mahendra Pandurang
authors.initials: MP
authors.lastname: Darokar
authors.forename: Arvind Singh
authors.initials: AS
authors.lastname: Negi
authors.forename: Madan Mohan
authors.initials: MM
authors.lastname: Gupta
authors.forename: Subhash Chandra
authors.initials: SC
authors.lastname: Singh
authors.forename: Jonnala Kotesh
authors.initials: JK
authors.lastname: Kumar
mesh_terms: D000480:Alkynes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D031176:Bidens / Q000737:chemistry*; D045744:Cell Line, Tumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects; D006801:Humans; D009996:Osmotic Fragility / Q000187:drug effects; D018515:Plant Leaves / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects
chemical_list: D000480:Alkynes; D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; C442780:plant extract, Bidens pilosa; C019518:phenylheptatriyne