Improved synthesis of polyfluorinated L-lysine for 19F NMR-based screening.
Polyfluorinated N-alpha-Fmoc-is an element of-Boc-L-lysine represents the best-in-class among a set of polyfluorinated amino acids (PFAs) which are useful tools for (19)F NMR-Based Screening. In this communication, optimized reaction conditions that allowed for the multi-gram preparation of this unnatural amino acid are reported.
Malgesini
Beatrice
B
Department of Chemistry, BU-Oncology, Nerviano Medical Sciences, Viale Pasteur 10, Nerviano, MI, 20014, Italy. beatrice.malgesini@nervianoms.com
Felder
Eduard
E
Mongelli
Nicola
N
Papeo
Gianluca
G
D005461:Fluorine / Q000737:chemistry*; D007554:Isotopes; D008239:Lysine / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008956:Models, Chemical; D015394:Molecular Structure
D007554:Isotopes; D005461:Fluorine; D008239:Lysine