Obesity, inflammation, and kidney disease.
Obesity and extreme obesity are associated with a wide range of well known comorbidities (cardiovascular disease, dyslipidemia, hypertension, diabetes mellitus, metabolic syndrome). Recently, the association between obesity and renal involvement has been accepted since several epidemiological and pathological studies support this relationship. However, the physiopathological mechanism of this association is not completely understood. Different mechanisms have been implicated in the production of these renal lesions. Between them, metabolic alterations and inflammatory adipocytokines have been suggested. This paper is a review of the association between inflammatory adipocytokines or metabolic syndrome with renal involvement. We also briefly report our experience in a cohort of extremely obese patients.
Navarro-Díaz
Maruja
M
Department of Nephrology, Hospital Germans Trias i Pujol, Autonomous University of Barcelona, Badalona, Barcelona, Spain.
Serra
Assumpta
A
López
Dolores
D
Granada
Marisa
M
Bayés
Beatriz
B
Romero
Ramón
R
D054392:Adipokines / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000453:epidemiology / Q000503:physiopathology*; D007674:Kidney Diseases / Q000453:epidemiology / Q000503:physiopathology*; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000503:physiopathology; D009765:Obesity / Q000150:complications / Q000503:physiopathology*; D012307:Risk Factors
D054392:Adipokines