Licorice preparations improve efficiency of chemotherapy and surgical treatment of transplanted tumors.
Experiments on animals with Lewis lung carcinoma and Ehrlich tumor showed that licorice (glycyrrhiza) extract and glyciram prepared from this plant improved the antitumor effect of cyclophosphamide. Glyciram reduced the toxic effect of the cytostatic on peripheral blood leukocytes. Licorice extract inhibited the growth of Ehrlich tumor and development of metastases in mice with Lewis lung carcinoma. Glyciram administered to mice after removal of Lewis lung carcinoma produced an antimetastatic effect and prevented relapses.
Gol'dberg
E D
ED
Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences.
Amosova
E N
EN
Zueva
E P
EP
Razina
T G
TG
Krylova
S G
SG
Zorikov
P S
PS
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D005260:Female; D006034:Glycyrrhetinic Acid / Q000627:therapeutic use; D006035:Glycyrrhiza / Q000737:chemistry*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009362:Neoplasm Metastasis / Q000188:drug therapy; D009368:Neoplasm Transplantation; D010936:Plant Extracts / Q000627:therapeutic use
D000970:Antineoplastic Agents; D010936:Plant Extracts; D006034:Glycyrrhetinic Acid