title: Asthmatic symptoms after exposure to ethylenebisdithiocarbamates and other pesticides in the Europit field studies.
abstract: We conducted a multicenter prospective study to assess the effects of occupational exposure to ethylenebisdithiocarbamate fungicides and/or other pesticides on self-reported asthma and asthmatic symptoms. This multicenter study was conducted among 248 workers exposed to pesticides and 231 non-exposed workers from five field studies. The five field studies were carried out in The Netherlands, Italy, Finland, and two studies in Bulgaria. Subjects constituting this cohort completed a self-administered questionnaire at baseline (before the start of exposure). Ethylenethiourea in urine was determined to assess exposure to ethylenebisdithiocarbamates. In multivariate analyses adjusted for all potential confounders (age, education, residence, smoking, gender, and field study), we found inverse associations, all not statistically significant, between occupational exposure to pesticides and asthma diagnosis (OR 0.41; 95% CI 0.15-1.11), complains of chest tightness (OR 0.60; 95% CI 0.36-1.02), wheeze (OR 0.56; 95% CI 0.32-0.98), asthma attack (OR 0.52; 95% CI 0.12-2.25), and asthma medication (OR 0.79; 95% CI 0.25-2.53). Furthermore, we reported null associations for multivariate analysis using ethylenethiourea as determinant for exposure. Although exposure to pesticides remains a potential health risk, our results do not suggest an association between exposure to ethylenebisdithiocarbamates and/or other pesticides used in our study on asthma and asthmatic symptoms.
authors.affiliation: Department of Epidemiology, Maastricht University, The Netherlands.
authors.forename: D
authors.initials: D
authors.lastname: Boers
authors.forename: L
authors.initials: L
authors.lastname: van Amelsvoort
authors.forename: C
authors.initials: C
authors.lastname: Colosio
authors.forename: E
authors.initials: E
authors.lastname: Corsini
authors.forename: S
authors.initials: S
authors.lastname: Fustinoni
authors.forename: L
authors.initials: L
authors.lastname: Campo
authors.forename: C
authors.initials: C
authors.lastname: Bosetti
authors.forename: C
authors.initials: C
authors.lastname: La Vecchia
authors.forename: T
authors.initials: T
authors.lastname: Vergieva
authors.forename: M
authors.initials: M
authors.lastname: Tarkowski
authors.forename: J
authors.initials: J
authors.lastname: Liesivuori
authors.forename: P
authors.initials: P
authors.lastname: Steerenberg
authors.forename: H
authors.initials: H
authors.lastname: van Loveren
mesh_terms: D000328:Adult; D001249:Asthma / Q000209:etiology* / Q000276:immunology / Q000652:urine; D002031:Bulgaria; D005028:Ethylenebis(dithiocarbamates) / Q000506:poisoning*; D005031:Ethylenethiourea / Q000032:analysis; D005260:Female; D005387:Finland; D005659:Fungicides, Industrial / Q000506:poisoning; D006801:Humans; D007558:Italy; D008297:Male; D015999:Multivariate Analysis; D009426:Netherlands; D009784:Occupational Diseases / Q000209:etiology* / Q000276:immunology / Q000652:urine; D016273:Occupational Exposure / Q000009:adverse effects / Q000032:analysis*; D016017:Odds Ratio; D010575:Pesticides / Q000506:poisoning*; D011446:Prospective Studies; D012135:Respiratory Sounds / Q000209:etiology / Q000276:immunology; D018570:Risk Assessment / Q000379:methods / Q000706:statistics & numerical data; D011795:Surveys and Questionnaires
chemical_list: D005028:Ethylenebis(dithiocarbamates); D005659:Fungicides, Industrial; D010575:Pesticides; D005031:Ethylenethiourea