[Hemolytic uremic syndrome caused by enterohaemorrhagic Escherichia coli].
Hemolytic uremic syndrome (HUS) is characterized by microangiopathic hemolytic anemia, plaquetopenia and kidney damage. It is the leading cause of acute renal failure in pediatric age and the second for chronic renal failure. Shiga toxin-producing Escherichia coli (STEC) is the first etiologic agent of HUS being its main reservoir cattle and transmitted via contaminated food. At present, there is no specific treatment to reduce the progression of HUS. The study of the mechanisms by which STEC infects and Shiga toxin induces HUS can help to find new strategies to prevent this disease.
Ibarra
Cristina
C
Laboratorio de Fisiopatogenia, Departamento de Fisiología, Facultad de Medicina, UBA. ibarra@fmed.uba.ar
Goldstein
Jorge
J
Silberstein
Claudia
C
Zotta
Elsa
E
Belardo
Marcela
M
Repetto
Horacio A
HA
D002648:Child; D054324:Enterohemorrhagic Escherichia coli; D004927:Escherichia coli Infections / Q000150:complications* / Q000628:therapy; D006463:Hemolytic-Uremic Syndrome / Q000382:microbiology* / Q000628:therapy; D006801:Humans; D022621:Shiga Toxin
D022621:Shiga Toxin