title: Age-related pregnancy results and further examination of bitches after aglepristone treatment of pyometra.
abstract: The cystic endometrial hyperplasia and pyometra complex is one of the most common uterine diseases in bitches. The appearance of pharmacological preparations containing anti-progestagens created new possibilities for pyometra treatment. The aim of this study was to evaluate the curative effect of the anti-progestagen aglepristone treatment of pyometra in bitches of different ages. Twenty four bitches of different breeds, aged from 0.8 to 9.5 years (21-48 kg) exhibiting clinical pyometra symptoms (two groups - I < or = 5 years, n = 14 and II >5 years, n = 10) were evaluated. Information about the general reproductive health was collected up to 54 months after anti-progestagen treatment. Remission of clinical symptoms and return of blood chemistry results and total leucocyte count to referential values were achieved in all cases within 14 days of treatment. Bitches were naturally mated at the first, and when unsuccessful, the second oestrus after treatment. In group I, no recurrence of pyometra symptoms was observed during following cycle(s). Eight bitches (57.1%) had a full-term pregnancy and the number of newborn pups ranged from 1 to 12. None of the bitches from the group II became pregnant. In conclusion, the basic indication for conservative pharmacological treatment of pyometra is preserving female fertility and obtaining offspring. The important conditions for successful aglepristone treatment are: the young age (up to 5 years) and the lack of detectible ovarian cysts. It seems necessary to mate bitches in the first or second oestrus after finishing treatment. The efficacy of treatment can be measured by the after-treatment pregnancy rate.
authors.affiliation: Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland. piotr_jurka@sggw.pl
authors.forename: P
authors.initials: P
authors.lastname: Jurka
authors.forename: A
authors.initials: A
authors.lastname: Max
authors.forename: K
authors.initials: K
authors.lastname: Hawryńska
authors.forename: M
authors.initials: M
authors.lastname: Snochowski
mesh_terms: D000375:Aging; D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004963:Estrenes / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005298:Fertility / Q000187:drug effects; D007958:Leukocyte Count; D011247:Pregnancy; D011256:Pregnancy Outcome; D011372:Progestins / Q000037:antagonists & inhibitors*; D055112:Pyometra / Q000188:drug therapy / Q000662:veterinary*; D016896:Treatment Outcome; D014463:Ultrasonography; D014599:Uterus / Q000000981:diagnostic imaging
chemical_list: D004963:Estrenes; D011372:Progestins; C419063:aglepristone