Iron status and cardiovascular risk factors in patients with haemodialysis versus patients with ischaemic heart disease.
OBJECTIVE
The study aimed to investigate whether imbalanced iron status in patients with haemodialysis coexisted with abnormal lipid profile, higher inflammatory status and altered growth hormone-insulin-like growth factor (GH-IGF)-I axis and to compare these biochemical markers with patients with ischaemic heart disease.


METHODS
Serum samples for biochemical and immunological analyses were collected from 74 normal subjects, 138 patients with ischaemic heart disease (IHD) and 115 patients on haemodialysis (HD).


RESULTS
Compared with normal subjects, lower serum iron, lower total iron-binding capacity (TIBC) and higher ferritin in HD patients coexisted with decreases in high-density lipoprotein cholesterol and total bilirubin as well as increases in lactate dehydrogenase (LDH), interleukin (IL)-6, C-reactive protein (CRP) and IL-10. Decreased IGF-I and increased GH were found in HD patients whereas unchanged GH-IGF axis were found in IHD patients. Compared with IHD, much higher ferritin, lower TIBC, lower bilirubin and higher LDH levels were found in HD patients.


CONCLUSIONS
Imbalanced iron status in patients on HD coexisted with abnormal lipid profiles, increased anaerobic activity and higher inflammatory status, which suggests that imbalanced iron status in HD patients may play a deleterious role in cardiovascular pathophysiology. Altered GH-IGF axis found in HD patients was more obvious than in IHD patients. This may imply that the GH-IGF axis system is modulated or adapted by HD.
Cheng
Yi-Chang
YC
Emergency Department, Taichung Veterans General Hospital, Taichung, Taiwan.
Kuo
Wei-Wen
WW
Wu
Chieh-Hsi
CH
Shu
Wen-Tong
WT
Kuo
Chia-Hua
CH
Hwang
Jin-Ming
JM
Hsu
Hsi-Hsien
HH
Chen
Li-Ming
LM
Huang
Chih-Yang
CY
Lee
Shin-Da
SD
D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000209:etiology*; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D019382:Human Growth Hormone / Q000502:physiology; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D015850:Interleukin-6 / Q000097:blood; D007501:Iron / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000378:metabolism*; D006435:Renal Dialysis; D012307:Risk Factors
D008076:Cholesterol, HDL; D015850:Interleukin-6; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D002097:C-Reactive Protein; D007501:Iron