Detection of breast cancer microcalcifications using a dual-modality SPECT/NIR fluorescent probe.
Efficient chemical synthesis of a trifunctional, hydroxyapatite-binding molecule, which provides simultaneous in vivo imaging by NIR fluorescence and SPECT/CT has been described. Quantitation by SPECT provides the "gold standard" by which NIR fluorescence tomography of breast cancer microcalcifications can now be compared and optimized.
Bhushan
Kumar R
KR
Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
Misra
Preeti
P
Liu
Fangbing
F
Mathur
Sanjeev
S
Lenkinski
Robert E
RE
Frangioni
John V
JV
D000818:Animals; D002114:Calcinosis; D017610:Calcium Compounds / Q000032:analysis; D017886:Durapatite / Q000032:analysis; D005260:Female; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D008325:Mammary Neoplasms, Experimental / Q000737:chemistry / Q000000981:diagnostic imaging* / Q000378:metabolism*; D015609:Organotechnetium Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D051381:Rats; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
D017610:Calcium Compounds; D005456:Fluorescent Dyes; D015609:Organotechnetium Compounds; D017886:Durapatite