title: 11-Phenyl-[b,e]-dibenzazepine compounds: novel antitumor agents.
abstract: A series of 11-phenyl-[b,e]-dibenzazepine compounds were synthesized and shown to be inhibitors of tumor cell proliferation with IC(50) values ranging from submicromolar to micromolar concentrations. Flow cytometric analyses of several active compounds demonstrated inhibition of cell cycle progression at the G(0)-G(1) phase transition resulting in G(0)-G(1) arrest.
authors.affiliation: Department of Chemistry, The University of Jordan, Amman, Jordan.
authors.forename: Raed A
authors.initials: RA
authors.lastname: Al-Qawasmeh
authors.forename: Yoon
authors.initials: Y
authors.lastname: Lee
authors.forename: Ming-Yu
authors.initials: MY
authors.lastname: Cao
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Gu
authors.forename: Stéphane
authors.initials: S
authors.lastname: Viau
authors.forename: Jeff
authors.initials: J
authors.lastname: Lightfoot
authors.forename: Jim A
authors.initials: JA
authors.lastname: Wright
authors.forename: Aiping H
authors.initials: AH
authors.lastname: Young
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003984:Dibenzazepines / Q000138:chemical synthesis* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D016193:G1 Phase; D006801:Humans; D020128:Inhibitory Concentration 50; D016192:Resting Phase, Cell Cycle; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D003984:Dibenzazepines