The prevalence and phenomenology of repetitive behavior in genetic syndromes.
We investigated the prevalence and phenomenology of repetitive behavior in genetic syndromes to detail profiles of behavior. The Repetitive Behaviour Questionnaire (RBQ) provides fine-grained identification of repetitive behaviors. The RBQ was employed to examine repetitive behavior in Angelman (N = 104), Cornelia de Lange (N = 101), Cri-du-Chat (N = 58), Fragile X (N = 191), Prader-Willi (N = 189), Lowe (N = 56) and Smith-Magenis (N = 42) syndromes and individuals with intellectual disability of heterogeneous aetiology (N = 56). Repetitive behavior was variable across syndromes. Fragile X syndrome scored highly on all subscales. Angelman syndrome demonstrated a significantly lowered probability for most behaviors. Prader-Willi, Cri-du-Chat and Smith-Magenis syndrome evidenced unique profiles of repetitive behavior. There is extreme heterogeneity of repetitive behavior across genetic syndromes, highlighting syndrome specific profiles.
Moss
Joanna
J
Centre for Neurodevelopmental Disorders, School of Psychology, University of Birmingham, Birmingham, UK.
Oliver
Chris
C
Arron
Kate
K
Burbidge
Cheryl
C
Berg
Katy
K
D000293:Adolescent; D000328:Adult; D017204:Angelman Syndrome / Q000453:epidemiology / Q000523:psychology; D002648:Child; D002675:Child, Preschool; D003410:Cri-du-Chat Syndrome / Q000453:epidemiology / Q000523:psychology; D003635:De Lange Syndrome / Q000453:epidemiology / Q000523:psychology; D005260:Female; D005600:Fragile X Syndrome / Q000453:epidemiology / Q000523:psychology; D006801:Humans; D008607:Intellectual Disability / Q000453:epidemiology* / Q000235:genetics / Q000523:psychology*; D008131:London; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011218:Prader-Willi Syndrome / Q000453:epidemiology / Q000523:psychology; D015995:Prevalence; D013239:Stereotyped Behavior; D011795:Surveys and Questionnaires; D013577:Syndrome; D055815:Young Adult