Relationship between body mass index, waist circumference and waist to hip ratio and the steroid hormone receptor status in breast carcinoma of pre- and postmenopausal women.
OBJECTIVE
To assess whether body mass index (BMI), waist circumference (WC) and waist to hip ratio (WRH) are associated to the steroid receptor status in breast carcinomas.


METHODS
Four hundred and seventy three women with breast malignancies stage I-III were included. Weight, height, the waist and hip circumferences (WC), body mass index (BMI), and the waist to hip ratio (WHR) were determined. The expression of estrogen (ER) and progesterone (PR) receptors was determined with immunohistochemistry.


RESULTS
Most women had central obesity (WC>or=88 and WHR>or=0.85 in 64.3 and 73.4%, respectively). The majority (78.1%) of the women had tumors that expressed at least one of the HR. BMI, WC and WHP were not related to the HR status in neither the pre- or postmenopausal women. Multivariate analysis confirmed these findings.


CONCLUSIONS
BMI, WC or WHR may not be good predictors of HR status in breast malignancies in either pre- or postmenopausal women.
Pinheiro
Rosilene Lima
RL
Section of Nutrition and Dietetics, National Cancer Institute (INCA), Rio de Janeiro, Brazil.
Sarian
Luis Otavio
LO
Pinto-Neto
Aarão Mendes
AM
Morais
Sirlei
S
Costa-Paiva
Lucia
L
D000328:Adult; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000453:epidemiology / Q000503:physiopathology*; D015897:Comorbidity; D005260:Female; D006801:Humans; D008875:Middle Aged; D009376:Neoplasms, Hormone-Dependent / Q000503:physiopathology*; D009765:Obesity / Q000453:epidemiology / Q000503:physiopathology; D017698:Postmenopause; D017697:Premenopause; D055105:Waist Circumference; D049629:Waist-Hip Ratio