title: Human chorionic gonadotropin ratio of hemoperitoneum versus venous serum improves early diagnosis of ectopic pregnancy.
abstract: OBJECTIVE
  To analyze the value of the hCG ratio of peritoneal serum versus venous serum (R(P/V)) for early diagnosis and prognostic evaluation of ectopic pregnancy (EP).
  
  
  METHODS
  Retrospective clinical study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  One hundred three women with hemoperitoneum and positive urine hCG tests underwent laparoscopy or laparotomy.
  
  
  METHODS
  Venous serum and peritoneal serum samples were obtained; ultrasound was performed in all the patients; dilatation and curettage was used in 28 patients.
  
  
  METHODS
  Quantitative hCG and R(P/V).
  
  
  RESULTS
  The R(P/V) in EP (5.55 +/- 4.32) is apparently greater than that in hemoperitoneum with intrauterine pregnancy (hIUP; 0.61 +/- 0.18). The median R(P/V) is 4.07 in the EP group versus 0.60 in the hIUP group, with a suggested threshold value of 1.0 for their differential diagnosis. Moreover, the R(P/V) of EP shows the dominant difference between the patients with active bleeding (8.03 +/- 3.29, n = 24) and the patients without active bleeding (4.59 +/- 3.88, n = 16) when the hCG level of venous serum is more than 1500 U/L.
  
  
  CONCLUSIONS
  R(P/V) could instantly diagnose ectopic pregnancy and differentiate it from hIUP.
authors.affiliation: Department of Obstetrics and Gynecology, the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, People's Republic of China.
authors.forename: YuDong
authors.initials: Y
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Zhao
authors.forename: YinCheng
authors.initials: Y
authors.lastname: Teng
authors.forename: LiHua
authors.initials: L
authors.lastname: Lu
authors.forename: JianQian
authors.initials: J
authors.lastname: Tong
mesh_terms: D006063:Chorionic Gonadotropin / Q000097:blood*; D003937:Diagnosis, Differential; D042241:Early Diagnosis; D005260:Female; D006465:Hemoperitoneum / Q000175:diagnosis* / Q000378:metabolism*; D006801:Humans; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000097:blood* / Q000175:diagnosis*; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D006063:Chorionic Gonadotropin