New phytotoxic metabolites from Pestalotiopsis sp. HC02, a Fungus Residing in Chondracris rosee gut.
Two new phytotoxic gamma-lactones, pestalotines A and B (1 and 2, resp.), along with 4-oxo-4H-pyran-3-acetic acid (3) and 6-hydroxyramulosin (=3,4,4a,5,6,7-hexahydro-6,8-dihydroxy-3-methyl-1H-2-benzopyran-1-one; 4), were isolateded from the culture of Pestalotiopsis sp. HC02, a fungus residing in the Chondracris rosee gut. Structures of the new metabolites were elucidated on the basis of their IR, NMR, and MS data. Pestalotines A and B (1 and 2, resp.) significantly inhibited the radical growth of Echinochloa crusgalli with IC(50) values of 1.85 x 10(-4) and 2.50 x 10(-4) M, respectively, comparable to that of 2-(2,4-dichlorophenoxy)acetic acid (0.94 x 10(-4) M) used as a positive control.
Zhang
Ying Lao
YL
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing 210093, P. R. China, (phone: +86-25-8359-5103; fax: +86-25-8368-6559).
Ge
Hui Ming
HM
Li
Fang
F
Song
Yong Chun
YC
Tan
Ren Xiang
RX
D000818:Animals; D001203:Ascomycota / Q000737:chemistry*; D031747:Echinochloa / Q000187:drug effects; D006110:Grasshoppers / Q000382:microbiology*; D006540:Herbicides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D011714:Pyrans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D006540:Herbicides; D007783:Lactones; D011714:Pyrans