Efficient and reproducible synthesis of [1-11C]acetyl chloride using the loop method.
[1-(11)C]Acetyl chloride ([(11)C]AcCl), an important [(11)C]acylating agent, was synthesized by reacting [(11)C]CO(2) with methylmagnesium bromide coated on the inner surface of a polyethylene loop (loop method). By optimizing the reaction conditions and synthesis parameters, [1-(11)C]phenylacetate and [1-(11)C]benzylacetate were produced from [(11)C]AcCl in high radiochemical yield and specific activity.
Arai
Takuya
T
Department of Molecular Probes, Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
Zhang
Ming-Rong
MR
Ogawa
Masanao
M
Fukumura
Toshimitsu
T
Kato
Koichi
K
Suzuki
Kazutoshi
K
D000085:Acetates / Q000138:chemical synthesis*; D000107:Acetylation; D002250:Carbon Radioisotopes / Q000737:chemistry*; D002712:Chlorides / Q000138:chemical synthesis*; D007553:Isotope Labeling / Q000379:methods
D000085:Acetates; D002250:Carbon Radioisotopes; D002712:Chlorides; C081124:acetyl chloride