title: Early auditory experience-induced composition/ratio changes of N-methyl-D-aspartate receptor subunit expression and effects of D-2-amino-5-phosphonovaleric acid chronic blockade in rat auditory cortex.
abstract: Auditory function can be affected by many factors, including environment and experience. In this study, we investigated whether early auditory experience mediates the regulation of the composition/ratio changes of the N-methyl-D-aspartic acid (NMDA) receptor subunits during development of the rat auditory cortex. We found that early sound exposure can increase expression of the NMDA receptor subunits and increase the composition/ratios of NMDA receptor subunits during the postnatal critical period. D-2-amino-5-phosphonovaleric acid (D-APV) could block and reverse the auditory experience-mediated changes, and there were marked reductions in expression levels and the composition/ratios of NMDA receptor subunits. These results indicate that the experience-dependent plasticity of the auditory cortex in the critical period during postnatal development has a marked influence on NMDA receptor expression in the rat and that changes in NMDA receptor subunit composition/ratios might mediate the early auditory experience-dependent plasticity crucial to auditory function.
authors.affiliation: School of Life Science, Institute of Cognitive Neuroscience and Shanghai Key Laboratory of Functional Magnetic Resonance Imaging, East China Normal University, Shanghai, China.
authors.forename: Yilei
authors.initials: Y
authors.lastname: Cui
authors.forename: Jiping
authors.initials: J
authors.lastname: Zhang
authors.forename: Rui
authors.initials: R
authors.lastname: Cai
authors.forename: Xinde
authors.initials: X
authors.lastname: Sun
mesh_terms: D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology*; D000161:Acoustic Stimulation; D000818:Animals; D001303:Auditory Cortex / Q000187:drug effects* / Q000254:growth & development* / Q000378:metabolism; D002452:Cell Count; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D015870:Gene Expression; D017403:In Situ Hybridization; D009473:Neuronal Plasticity / Q000502:physiology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics / Q000378:metabolism*
chemical_list: D018691:Excitatory Amino Acid Antagonists; D012333:RNA, Messenger; D016194:Receptors, N-Methyl-D-Aspartate; D015763:2-Amino-5-phosphonovalerate