title: Role of M3 receptor in aconitine/barium-chloride-induced preconditioning against arrhythmias in rats.
abstract: We demonstrated here that an initial treatment with aconitine- or barium-chloride-induced arrhythmias and resulted in reduced susceptibility of the heart to the induction of arrhythmias by a repeated drug treatment 24 h after the initial one, a delayed preconditioning cardioprotection. This delayed preconditioning was accompanied by enhanced expression of cardiac muscarinic M(3) receptor and abolished by M(3)-selective antagonist. We conclude that muscarinic M(3) receptors might play an important role in conferring the pharmacological preconditioning against arrhythmias. This study thus expands our understanding of the cellular function and pathophysiological roles of muscarinic M(3) receptor and reconsolidates our view of cardioprotective effects of muscarinic M(3) receptor on myocardium.
authors.affiliation: Department of Pharmacology, Harbin Medical University, Harbin, 150081, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Juan
authors.initials: J
authors.lastname: Du
authors.forename: Yang
authors.initials: Y
authors.lastname: Gao
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ben-zhi
authors.initials: BZ
authors.lastname: Cai
authors.forename: Hua
authors.initials: H
authors.lastname: Zhao
authors.forename: Han-ping
authors.initials: HP
authors.lastname: Qi
authors.forename: Zhi-min
authors.initials: ZM
authors.lastname: Du
authors.forename: Yan-jie
authors.initials: YJ
authors.lastname: Lu
authors.forename: Bao-feng
authors.initials: BF
authors.lastname: Yang
mesh_terms: D000157:Aconitine / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000378:metabolism / Q000517:prevention & control*; D017609:Barium Compounds / Q000494:pharmacology / Q000627:therapeutic use*; D002712:Chlorides / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D019157:Ischemic Preconditioning, Myocardial / Q000379:methods*; D008297:Male; D018727:Muscarinic Antagonists / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D043587:Receptor, Muscarinic M3 / Q000819:agonists / Q000037:antagonists & inhibitors / Q000502:physiology*; D013997:Time Factors
chemical_list: D017609:Barium Compounds; D002712:Chlorides; D018727:Muscarinic Antagonists; D043587:Receptor, Muscarinic M3; C024986:barium chloride; D000157:Aconitine