Thrombotic thrombocytopenic purpura precipitated by acute pancreatitis: a report of seven cases from a regional UK TTP registry.
Thrombotic thrombocytopenic purpura (TTP) may be idiopathic or secondary. We report seven TTP cases precipitated by pancreatitis. The patients were admitted with acute pancreatitis and at that time had no clinical or laboratory features of TTP. The median time to develop TTP after pancreatitis was 3 d. The patients had moderately reduced ADAMTS13 activity (mean activity 49%; normal range 66-126%) with no evidence of anti-ADAMTS13 inhibitory autoantibodies. The median number of plasma exchanges to remission was 10 (range 7-14) and no additional treatment with immunosuppression was required to maintain remission. There have been no relapses to date.
McDonald
V
V
Haemostasis Research Unit, UCL Department of Haematology, London, UK. v.mcdonald@ucl.ac.uk
Laffan
M
M
Benjamin
S
S
Bevan
D
D
Machin
S
S
Scully
M A
MA
D051722:ADAM Proteins / Q000032:analysis; D000071120:ADAMTS13 Protein; D000208:Acute Disease; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000032:analysis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D010195:Pancreatitis / Q000150:complications* / Q000276:immunology / Q000628:therapy; D010951:Plasma Exchange; D011697:Purpura, Thrombotic Thrombocytopenic / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D016896:Treatment Outcome; D055815:Young Adult
D001323:Autoantibodies; D007074:Immunoglobulin G; D051722:ADAM Proteins; D000071120:ADAMTS13 Protein; C099604:ADAMTS13 protein, human