title: Personalizing nutrigenomics research through community based participatory research and omics technologies.
abstract: Personal and public health information are often obtained from studies of large population groups. Risk factors for nutrients, toxins, genetic variation, and more recently, nutrient-gene interactions are statistical estimates of the percentage reduction in disease in the population if the risk were to be avoided or the gene variant were not present. Because individuals differ in genetic makeup, lifestyle, and dietary patterns than those individuals in the study population, these risk factors are valuable guidelines, but may not apply to individuals. Intervention studies are likewise limited by small sample sizes, short time frames to assess physiological changes, and variable experimental designs that often preclude comparative or consensus analyses. A fundamental challenge for nutrigenomics will be to develop a means to sort individuals into metabolic groups, and eventually, develop risk factors for individuals. To reach the goal of personalizing medicine and nutrition, new experimental strategies are needed for human study designs. A promising approach for more complete analyses of the interaction of genetic makeups and environment relies on community-based participatory research (CBPR) methodologies. CBPR's central focus is developing a partnership among researchers and individuals in a community that allows for more in depth lifestyle analyses but also translational research that simultaneously helps improve the health of individuals and communities. The USDA-ARS Delta Nutrition Intervention Research program exemplifies CBPR providing a foundation for expanded personalized nutrition and medicine research for communities and individuals.
authors.affiliation: USDA-ARS Delta NIRI. 900 South Shackleford Drive, Little Rock, AR 72211, USA.
authors.forename: Beverly
authors.initials: B
authors.lastname: McCabe-Sellers
authors.forename: Dalia
authors.initials: D
authors.lastname: Lovera
authors.forename: Henry
authors.initials: H
authors.lastname: Nuss
authors.forename: Carolyn
authors.initials: C
authors.lastname: Wise
authors.forename: Baitang
authors.initials: B
authors.lastname: Ning
authors.forename: Candee
authors.initials: C
authors.lastname: Teitel
authors.forename: Beatrice Shelby
authors.initials: BS
authors.lastname: Clark
authors.forename: Terri
authors.initials: T
authors.lastname: Toennessen
authors.forename: Bridgett
authors.initials: B
authors.lastname: Green
authors.forename: Margaret L
authors.initials: ML
authors.lastname: Bogle
authors.forename: Jim
authors.initials: J
authors.lastname: Kaput
mesh_terms: D055812:Community-Based Participatory Research / Q000379:methods*; D005820:Genetic Testing; D014644:Genetic Variation; D006801:Humans; D054647:Nutrigenomics / Q000379:methods* / Q000639:trends; D012107:Research Design; D014481:United States; D016885:United States Department of Agriculture