Effect of exogenous calcium deficit on blood pressure and modification of brain proteins GAP-43 and BASP1 in SHR and WKY rats.
We studied the effect of drinking of low mineralized water containing 8 mg/liter Ca2+ on blood pressure and content of brain proteins in synaptosomes of SHR and WKY rats. Blood pressure increased in WKY rats, but not in SHR rats. In SHR rats, Ca2+ deficit reduced the content of GAP-43 protein and induced the appearance of its fragment GAP-43-3 in brain synaptosomes. In WKY rats, the content of this protein did not change, and its fragment GAP-43-3 was absent. No structural changes in BASP1 protein were found.
Klyueva
N Z
NZ
I. P. Paviov Institute of Physiology, Russian Academy of Sciences
Antonova
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OS
Petrova
E I
EI
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002118:Calcium / Q000172:deficiency*; D002148:Calmodulin-Binding Proteins / Q000378:metabolism*; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D005260:Female; D019922:GAP-43 Protein / Q000378:metabolism*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*
D002148:Calmodulin-Binding Proteins; D003598:Cytoskeletal Proteins; D019922:GAP-43 Protein; C521921:GAP-43-3 protein; D009419:Nerve Tissue Proteins; C066853:Basp1 protein, rat; D002118:Calcium