Thyroid dysfunction after combined therapy for laryngeal cancer: a prospective study.
OBJECTIVE
The purpose of this study was to assess the incidence of the thyroid dysfunction in a group of patients treated with laryngectomy and radiotherapy for larynx cancer and to analyze the risk factors related to the development of hypothyroidism.


METHODS
This was a prospective study conducted in a tertiary center hospital.


METHODS
Thyroid function tests have been applied to 75 patients treated with surgery and radiotherapy preoperatively, before radiotherapy, and postoperatively. Risk factors have been analyzed by carrying out a multivariate analysis.


RESULTS
All the patients were men with the mean age of 59.4 and an average follow-up of 28.6 months. The incidence of hypothyroidism was 49.3 percent. The average time to detection of hypothyroidism was 6 months after the completion of treatment. Radiotherapy dose, type of laryngectomy, extent of neck dissection, implementation of thyroid lobectomy, and presence of thyroiditis in specimens were risk factors for thyroid dysfunction.


CONCLUSIONS
It is important to check the thyroid function periodically in these patients especially with risk factor to obtain early diagnosis and appropriate treatment.
Alkan
Seyhan
S
Department of Otorhinolaryngology and Head and Neck Surgery, Sişli Etfal Teaching and Research Hospital, Istanbul, Turkey. seyhanalkan@hotmail.com
Baylancicek
Serdar
S
Ciftçic
Memet
M
Sozen
Esra
E
Dadaş
Burhan
B
D016009:Chi-Square Distribution; D003131:Combined Modality Therapy; D006801:Humans; D015994:Incidence; D007822:Laryngeal Neoplasms / Q000150:complications / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D007825:Laryngectomy / Q000009:adverse effects / Q000379:methods; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection / Q000009:adverse effects / Q000379:methods; D009367:Neoplasm Staging; D011446:Prospective Studies; D011879:Radiotherapy Dosage; D012307:Risk Factors; D013959:Thyroid Diseases / Q000453:epidemiology / Q000209:etiology*; D013960:Thyroid Function Tests