Medicinal flowers. XXIV. Chemical structures and hepatoprotective effects of constituents from flowers of Hedychium coronarium.
The 80% aqueous acetone extract from the flowers of Hedychium coronarium was found to show a protective effect on D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes. On the other hand, two new labdane-type diterpene glycosides, coronalactosides I (1) and II (2), and a new labdane-type trinorditerpene, coronadiene (3), were isolated together with 8 known compounds from the extracts, which were obtained with chloroform and 80% aqueous acetone from the flowers of H. coronarium. The structures of new constituents were elucidated on the basis of chemical and physicochemical evidence. In addition, the principal constituents, coronaririn C and 15-hydroxylabda-8(17),11,13-trien-16,15-olide, displayed hepatoprotective effects, which were stronger than that of the hepatoprotective agent, silybin.
Nakamura
Seikou
S
Kyoto Pharmaceutical University, Yamashina-ku, Kyoto, Japan.
Okazaki
Yoshie
Y
Ninomiya
Kiyofumi
K
Morikawa
Toshio
T
Matsuda
Hisashi
H
Yoshikawa
Masayuki
M
D000096:Acetone; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification*; D035264:Flowers / Q000737:chemistry; D022781:Hepatocytes / Q000187:drug effects; D006868:Hydrolysis; D008297:Male; D051379:Mice; D008968:Molecular Conformation; D009097:Multienzyme Complexes / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D020011:Protective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000077385:Silybin; D012838:Silymarin / Q000494:pharmacology; D012997:Solvents; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared; D030521:Zingiberaceae / Q000737:chemistry*; D001617:beta-Glucosidase / Q000737:chemistry
D004224:Diterpenes; D009097:Multienzyme Complexes; D010936:Plant Extracts; D020011:Protective Agents; D012838:Silymarin; D012997:Solvents; C534252:coronadiene; C534250:coronalactoside I; C534251:coronalactoside II; D000096:Acetone; D000077385:Silybin; C039827:naringinase; D001617:beta-Glucosidase