title: A novel locus DFNA59 for autosomal dominant nonsyndromic hearing loss maps at chromosome 11p14.2-q12.3.
abstract: Autosomal dominant nonsyndromic hearing loss (ADNSHL) accounts for about one-fifth of hereditary hearing loss in humans. In the present study, we have analyzed a three-generation family with 14 of its members manifesting ADNSHL, using a genome-wide linkage mapping approach. We found a novel locus DFNA59 between the D11S929 and D11S480 markers in the chromosome location 11p14.2-q12.3. The highest two-point lod score of 5.72 at recombination fraction = 0 was obtained for D11S4152, D11S4154, D11S1301, D11S905 and D11S1344. The critical genomic region comprising about 37 megabases of DNA is proposed to carry a gene for ADNSHL in the family. About 50 cochlear-expressed genes mapping to the region are strong candidates which we propose to examine to identify the gene responsible for the hearing impairment.
authors.affiliation: Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India.
authors.forename: Arunima
authors.initials: A
authors.lastname: Chatterjee
authors.forename: Rajeev
authors.initials: R
authors.lastname: Jalvi
authors.forename: Nishtha
authors.initials: N
authors.lastname: Pandey
authors.forename: R
authors.initials: R
authors.lastname: Rangasayee
authors.forename: Anuranjan
authors.initials: A
authors.lastname: Anand
mesh_terms: D000293:Adolescent; D001301:Audiometry, Pure-Tone; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D005260:Female; D005799:Genes, Dominant; D005819:Genetic Markers; D006312:Hearing Loss, Bilateral / Q000151:congenital / Q000235:genetics / Q000503:physiopathology; D006319:Hearing Loss, Sensorineural / Q000151:congenital / Q000235:genetics* / Q000503:physiopathology; D006801:Humans; D008126:Lod Score; D008297:Male; D010375:Pedigree
chemical_list: D005819:Genetic Markers