Allergic contact dermatitis from EMLA cream: concomitant sensitization to both local anesthetics lidocaine and prilocaine.
Local anesthetics are widely used drugs. In contrast to the local anesthetics of the ester group, the ones of the amide group (for example prilocaine and lidocaine) are considered to be rare sensitizers. Positive patch test results to both prilocaine and lidocaine in EMLA cream might indicate potential cross-reactivity.
Timmermans
Martine W H
MW
Department of Dermatology and Allergology,VU University Medical Centre, De Boelelaan 1117, Amsterdam NL-1081 HV, The Netherlands. mwh.timmermans@vumc.nl
Bruynzeel
Derk P
DP
Rustemeyer
Thomas
T
D000369:Aged, 80 and over; D000779:Anesthetics, Local / Q000009:adverse effects; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D003875:Drug Eruptions / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000009:adverse effects*; D000077442:Lidocaine, Prilocaine Drug Combination; D009824:Ointments / Q000009:adverse effects; D011318:Prilocaine / Q000009:adverse effects*
D000779:Anesthetics, Local; D000077442:Lidocaine, Prilocaine Drug Combination; D009824:Ointments; D011318:Prilocaine; D008012:Lidocaine