Disseminated cutaneous histoplasmosis in acquired immunodeficiency syndrome: report of 23 cases.
Disseminated cutaneous histoplasmosis is an opportunistic infection in patients with acquired immunodeficiency syndrome. We report a series of 23 cases (21 men, two women; median age 29 years) with disseminated cutaneous histoplasmosis seen at two hospital centres. Most of the patients (21/23) were classified as stage C3. The most common dermatological findings were papules, crusting plaques, nodules and ulcers, mainly located on the face and chest. Of the 23 cases, 15 (65%) had pulmonary involvement. Amphotericin B and itraconazole were the main drugs used for treatment. Treatment response was variable: four of the patients were cured, six improved and remain stable, nine patients died, and four patients were lost to follow-up.
Bonifaz
A
A
Dermatology Service and Mycology Department, Hospital Angeles and Hospital de Enfermedades Guatamalan Social Security Institute, Guatamala City, Guatamala. a_bonifaz@yahoo.com.mx
Chang
P
P
Moreno
K
K
Fernández-Fernández
V
V
Montes de Oca
G
G
Araiza
J
J
Ponce
R M
RM
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000473:pathology*; D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D005260:Female; D015497:HIV-1; D006660:Histoplasmosis / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008297:Male; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B