Growth factor delivery approaches in hydrogels.
The controlled delivery of growth factors is a very challenging task because many different issues have to be addressed to develop the best suited system. A wide range of approaches have been employed for the controlled delivery of growth factors by hydrogels. Direct loading, electrostatic interaction, covalent binding, and the use of carriers are the main strategies presented in the literature. They are all detailed in the first part of this review. Recent work emphasizing biologically inspired strategies is also included. Also, both natural and synthetic materials are discussed. The second part comprises the methods to evaluate such delivery approaches. Both in vivo and in vitro techniques are presented. Improvements based on the discussed approaches may illustrate future paths toward the development of an ideal growth factor delivery system.
Silva
Amanda K Andriola
AK
Université d'Evry Val d'Essonne, Ecole doctorale des Génomes Aux Organismes, Boulevard François Mitterrand 91025 Evry, cedex France.
Richard
Cyrille
C
Bessodes
Michel
M
Scherman
Daniel
D
Merten
Otto-Wilhelm
OW
D001672:Biocompatible Materials; D016503:Drug Delivery Systems; D020100:Hydrogels; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage*
D001672:Biocompatible Materials; D020100:Hydrogels; D036341:Intercellular Signaling Peptides and Proteins