A severe case of intracranial hemorrhage due to alloimmune thrombocytopenia.
Alloimmune thrombocytopenia (AIT) is an important cause of intrauterine hemorrhagic lesions that result from platelet-antigen incompatibility between mother and foetus. Foetal platelets are destroyed by cross-reactive maternal antibodies that cross the placenta. The most serious complication of AIT is foetal intracranial bleeding that may eventually result in intrauterine death or severe neurological impairments.
Cota
Francesco
F
Division of Neonatology, Department of Pediatrics, Catholic University of the Sacred Heart, Rome, Italy. frnchr@libero.it
Zuppa
Antonio Alberto
AA
Luciano
Rita
R
Gallini
Francesca
F
Savarese
Immacolata
I
Alighieri
Giovanni
G
Orchi
Claudia
C
Romagnoli
Costantino
C
D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn; D020300:Intracranial Hemorrhages / Q000000981:diagnostic imaging / Q000209:etiology*; D011247:Pregnancy; D054098:Thrombocytopenia, Neonatal Alloimmune / Q000000981:diagnostic imaging*; D016216:Ultrasonography, Prenatal