Eumycetoma caused by Cladophialophora bantiana successfully treated with itraconazole.
A 57-year-old male presented with dermatosis of the dorsum of the foot consisting of tumefaction, deformity and sinus tract formation. The direct examination of exudates as well as the biopsy tissue, demonstrated the presence of black granules. A dematiaceous fungus was isolated from the lesions and was identified by ribosomal DNA sequencing as Cladophialophora bantiana. This is the second report of this fungus as an etiologic agent of eumycetoma in humans. Clinical and mycologic cure was achieved after 20 months of treatment with itraconazole at a starting dose of 300 mg/day that was tapered during the course of therapy. The patient's isolate had an itraconazole MIC of 0.012 microg/ml.
Bonifaz
Alexandro
A
Dermatology Service & Mycology Department, General Hospital of Mexico, Del Valle, Mexico. a_bonifaz@yahoo.com.mx
De Hoog
Sybren
S
McGinnis
Michael R
MR
Saúl
Amado
A
Rodríguez-Cortés
Octavio
O
Araiza
Javier
J
Cruz
Mariana
M
Mercadillo
Patricia
P
D000935:Antifungal Agents / Q000627:therapeutic use*; D001203:Ascomycota / Q000145:classification / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D005533:Foot Dermatoses / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D008271:Mycetoma / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D016896:Treatment Outcome
D000935:Antifungal Agents; D017964:Itraconazole