[Role of astrocytes activated by albumin in epileptogenesis].
BACKGROUND
Epilepsy is one of the major neurological disorders characterized by spontaneous and recurrent seizures. Despite progress in the understanding of epilepsy, the exact network underlying the seizures is unclear.


METHODS
Actually the role of astrocytes in modulation of neuronal activity and the synaptic transmission is clear, making astrocytes as important players in processing of information in the central nervous system. These characteristics make us think that astrocytes have an important role in the epileptogenesis. Disruption of blood brain-barrier let the pass of albumin, and it could uptake into astrocytes. Numerous authors suggest that this can contribute to epileptogenesis.


CONCLUSIONS
In view the data obtained from these factors (astrocytes and albumin), future studies will undoubted further to know its relation with epileptogenesis in humans and as therapeutics aims.
Herrera-Peco
I
I
Servicio de Neurocirugía, Hospital Universitario de la Princesa, 28006 Madrid, España.
Sola
R G
RG
Osejo
V
V
Wix-Ramos
R
R
Pastor
J
J
D000418:Albumins / Q000378:metabolism*; D001253:Astrocytes / Q000166:cytology / Q000378:metabolism*; D001812:Blood-Brain Barrier / Q000033:anatomy & histology / Q000502:physiology; D004827:Epilepsy / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D013569:Synapses / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology
D000418:Albumins