title: p204, a p200 family protein, as a multifunctional regulator of cell proliferation and differentiation.
abstract: The interferon-inducible p200 family comprises a group of homologous mouse and human proteins. Most of these have an N-terminal DAPIN domain and one or two partially conserved, 200 amino acid long C-terminal domains (designated as 200X domain). These proteins play important roles in the regulation of cell proliferation, tissue differentiation, apoptosis and senescence. p200 family proteins are involved also in autoimmunity and the control of tumor growth. These proteins function by binding to various target proteins (e.g. transcription factors, signaling proteins, oncoproteins and tumor suppressor proteins) and modulating target activity. This review concentrates on p204, a murine member of the family and its roles in regulating cell proliferation, cell and tissue differentiation (e.g. of skeletal muscle myotubes, beating cardiac myocytes, osteoblasts, chondrocytes and macrophages) and signaling by Ras proteins. The expression of p204 in various tissues as promoted by tissue-specific transcription factors, its distribution among subcellular compartments, and the controls of these features are also discussed.
authors.affiliation: Department of Orthopaedic Surgery, New York University School of Medicine, New York, 10003, United States.
authors.forename: Yi
authors.initials: Y
authors.lastname: Luan
authors.forename: Peter
authors.initials: P
authors.lastname: Lengyel
authors.forename: Chuan-Ju
authors.initials: CJ
authors.lastname: Liu
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D005786:Gene Expression Regulation; D051379:Mice; D032446:Myoblasts / Q000502:physiology; D009687:Nuclear Proteins / Q000502:physiology*; D010006:Osteoblasts / Q000502:physiology; D010750:Phosphoproteins / Q000502:physiology*; D039904:Pluripotent Stem Cells / Q000502:physiology; D016283:Proto-Oncogene Proteins p21(ras) / Q000037:antagonists & inhibitors; D012335:RNA, Ribosomal / Q000037:antagonists & inhibitors; D014779:Virus Replication / Q000187:drug effects
chemical_list: C489664:Ifi16 protein, mouse; D009687:Nuclear Proteins; D010750:Phosphoproteins; D012335:RNA, Ribosomal; D016283:Proto-Oncogene Proteins p21(ras)