Prenylated 2-arylbenzofurans from Artocarpus petelotii.
Further phytochemical investigation on the root barks of Artocarpus petelotii Gagnep afforded two new prenylated 2-arylbenzofurans, artopetelins L and M (1 and 2), as well as a known compound, lakoochin B (3). Their structures were identified by spectroscopic methods. Artopetelins B-E (5-8), four 2-arylbenzofurans previously isolated from this plant, and lakoochin B (3) were potent against HepG2 (IC(50) = 14.4-44.4 microM) and MCF-7 (IC(50) = 29.7-59.1 microM).
Shen
Hong
H
Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, P. R. China.
Hou
Ai-Jun
AJ
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031622:Artocarpus / Q000737:chemistry*; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005260:Female; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013267:Stilbenes
D000972:Antineoplastic Agents, Phytogenic; D001572:Benzofurans; D004365:Drugs, Chinese Herbal; D013267:Stilbenes; C533657:artopetelin L; C533656:artopetelin M; C485027:lakoochin B