Synthesis, antimicrobial and cytotoxic activities of 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles.
A new class of 1,3,4-oxadiazoles were prepared from acid hydrazides on treatment with different carboxylic acids in the presence of phosphorus oxychloride. Interconversion of oxadiazoles to thiadiazoles and triazoles was carried out with appropriate reagents. The antimicrobial and cytotoxic activities of compounds 7a-d to 12a-d were tested. Compounds 10d and 12d showed pronounced antimicrobial activity. Further, compound 10d exhibited maximum cytotoxicity.
Padmavathi
V
V
Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India.
Sudhakar Reddy
G
G
Padmaja
A
A
Kondaiah
P
P
Ali-Shazia
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010069:Oxadiazoles / Q000138:chemical synthesis / Q000494:pharmacology; D013830:Thiadiazoles / Q000138:chemical synthesis / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis / Q000494:pharmacology
D000890:Anti-Infective Agents; D006571:Heterocyclic Compounds; D010069:Oxadiazoles; D013830:Thiadiazoles; D014230:Triazoles