title: Magnetization transfer proportion: a simplified measure of dose response for polymer gel dosimetry.
abstract: The response to radiation of polymer gel dosimeters has most often been described by measuring the nuclear magnetic resonance transverse relaxation rate as a function of dose. This approach is highly dependent upon the choice of experimental parameters, such as the echo spacing time for Carr-Purcell-Meiboom-Gill-type pulse sequences, and is difficult to optimize in imaging applications where a range of doses are applied to a single gel, as is typical for practical uses of polymer gel dosimetry. Moreover, errors in computing dose can arise when there are substantial variations in the radiofrequency (B1) field or resonant frequency, as may occur for large samples. Here we consider the advantages of using magnetization transfer imaging as an alternative approach and propose the use of a simplified quantity, the magnetization transfer proportion (MTP), to assess doses. This measure can be estimated through two simple acquisitions and is more robust in the presence of some sources of system imperfections. It also has a dependence upon experimental parameters that is independent of dose, allowing simultaneous optimization at all dose levels. The MTP is shown to be less susceptible to B1 errors than are CPMG measurements of R2. The dose response can be optimized through appropriate choices of the power and offset frequency of the pulses used in magnetization transfer imaging.
authors.affiliation: Vanderbilt University Institute of Imaging Science, Nashville, TN 37232-2675, USA. heather.whitney@vanderbilt.edu
authors.forename: Heather M
authors.initials: HM
authors.lastname: Whitney
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Gochberg
authors.forename: John C
authors.initials: JC
authors.lastname: Gore
mesh_terms: D003198:Computer Simulation; D004307:Dose-Response Relationship, Radiation; D004867:Equipment Design; D006801:Humans; D008280:Magnetics; D008689:Methacrylates / Q000737:chemistry; D015233:Models, Statistical; D011108:Polymers / Q000737:chemistry*; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D015203:Reproducibility of Results; D014867:Water / Q000737:chemistry
chemical_list: D008689:Methacrylates; D011108:Polymers; D014867:Water; C008384:methacrylic acid