A distribution of two SNPs in exon 10 of the FSHR gene among the women with a diminished ovarian reserve in Ukraine.
OBJECTIVE
To evaluate the association between phenotype and follicle stimulating hormone receptor (FSHR) genotype in women with ovarian dysfunction and patients with "poor response" to gonadotropin stimulation of ovulation.


METHODS
FSHR gene SNPs were analyzed by PCR and RFLP. "Poor responders" (ovarian dysfunction) group and "good responders" group constituted the study group. Normo-ovulatory women who gave birth to naturally conceived children formed control groups: under 35 years of age (control I) and over 35 years of age (control II).


RESULTS
The frequency of Ala307-Ser680/Ala307-Ser680 genotype was significantly more prevalent in the ovarian dysfunction group (26%) compared to the control I (7.7%) (P < 0.001) and a "good responders" group (12.5%) (P < 0.05); and in a "poor responders" group (33.3%) compared to a "good responders" group (P < 0.05), control I (P < 0.001) and control II (17.5%) (P < 0.05).


CONCLUSIONS
Our data shows the prevalence of the Ala307-Ser680/ Ala307-Ser680 genotype in the both groups of patients. The finding should have impact on the delineation of stimulation protocols.
Livshyts
Ganna
G
Department of Human Genomics, Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Kiev, Ukraine.
Podlesnaja
Svetlana
S
Kravchenko
Sergey
S
Sudoma
Iryna
I
Livshits
Ludmila
L
D000328:Adult; D019943:Amino Acid Substitution; D005091:Exons; D005260:Female; D043373:Follicle Stimulating Hormone, Human / Q000627:therapeutic use; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology; D006080:Ovarian Follicle / Q000187:drug effects / Q000503:physiopathology*; D010062:Ovulation Induction; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D011962:Receptors, FSH / Q000235:genetics* / Q000378:metabolism; D014455:Ukraine
D043373:Follicle Stimulating Hormone, Human; D011962:Receptors, FSH