title: Antibacterial neurymenolides from the Fijian red alga Neurymenia fraxinifolia.
abstract: Two novel alpha-pyrone macrolides, neurymenolides A (1) and B (2), were isolated from the Fijian red alga Neurymenia fraxinifolia and characterized using a combination of NMR and mass spectral analyses. These molecules represent only the second example of alpha-pyrone macrolides, with 1 existing as interchanging atropisomers due to restricted rotation about the alpha-pyrone ring system. Neurymenolide A (1) displayed moderately potent activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VREF).
authors.affiliation: School of Chemistry & Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, 30332, USA.
authors.forename: E Paige
authors.initials: EP
authors.lastname: Stout
authors.forename: Adam P
authors.initials: AP
authors.lastname: Hasemeyer
authors.forename: Amy L
authors.initials: AL
authors.lastname: Lane
authors.forename: Theresa M
authors.initials: TM
authors.lastname: Davenport
authors.forename: Sebastian
authors.initials: S
authors.lastname: Engel
authors.forename: Mark E
authors.initials: ME
authors.lastname: Hay
authors.forename: Craig R
authors.initials: CR
authors.lastname: Fairchild
authors.forename: Jacques
authors.initials: J
authors.lastname: Prudhomme
authors.forename: Karine
authors.initials: K
authors.lastname: Le Roch
authors.forename: William
authors.initials: W
authors.lastname: Aalbersberg
authors.forename: Julia
authors.initials: J
authors.lastname: Kubanek
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D016984:Enterococcus faecium / Q000187:drug effects; D018942:Macrolides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011753:Pyrones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000461:Rhodophyta / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects; D013237:Stereoisomerism
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; D011753:Pyrones; C534975:neurymenolide A; C534976:neurymenolide B