title: Thyroid dose estimation with potassium iodide (KI) administration in a nuclear emergency.
abstract: In a breach-of-containment nuclear reactor accident, the near-field exposure is primarily through inhalation of radioiodine. Thyroid blockade by oral potassium iodide (KI) is a practical and effective protective measure for the general public in such an emergency. The retention functions incorporating the thyroid blocking effects by KI have been derived using a standard three-compartment model of iodine metabolism. This allows more accurate estimation of the thyroid dose by calculating the blocking factor.
authors.affiliation: National Radiation Emergency Medical Center, Korea Institute of Radiological and Medical Science, Seoul, South Korea. mjang@kirams.re.kr
authors.forename: M
authors.initials: M
authors.lastname: Jang
authors.forename: H K
authors.initials: HK
authors.lastname: Kim
authors.forename: C W
authors.initials: CW
authors.lastname: Choi
authors.forename: C S
authors.initials: CS
authors.lastname: Kang
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics / Q000494:pharmacology*; D011193:Potassium Iodide / Q000008:administration & dosage* / Q000378:metabolism; D011832:Radiation Injuries / Q000517:prevention & control; D018788:Radioactive Hazard Release; D013961:Thyroid Gland / Q000187:drug effects* / Q000473:pathology; D014018:Tissue Distribution
chemical_list: D007457:Iodine Radioisotopes; D011193:Potassium Iodide