[Case of interstitial pneumonia induced by intravesical administration of Bacillus Calmette-Guerin].
An 81-year-old man with superficial bladder cancer, which was detected after he complained of hematuria and pain on urination, was treated 5 times with intravesical bacillus Calmette-Guerin (BCG) administration. Since he complained of a dry cough and dyspnea associated with severe hypoxemia, and had extensive bilateral pulmonary infiltrative shadows on his chest X-ray film, he was admitted to our hospital. He was treated with methylprednisolone under a diagnosis of interstitial pneumonia. Because BCG infection and/or bacterial pneumonia could not be denied, we administered antituberculosis agent and antibiotics. However, he died due to respiratory failure on 10th day after admission. Because a lymphocyte stimulation test for BCG was strongly positive, we established a diagnosis of interstitial pneumonia induced by intravesical administration of BCG. Because the mortality rate is high, the evaluation of interstitial pneumonia before administration of BCG is crucial.
Yamamoto
Akihito
A
Tobu Chiiki Hospital.
Koyama
Ryo
R
Kido
Kenji
K
Koike
Kengo
K
Toba
Michie
M
Takahashi
Kazuhisa
K
D000283:Administration, Intravesical; D000369:Aged, 80 and over; D001500:BCG Vaccine / Q000008:administration & dosage* / Q000009:adverse effects*; D017809:Fatal Outcome; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000209:etiology*; D008297:Male; D012131:Respiratory Insufficiency / Q000209:etiology; D001749:Urinary Bladder Neoplasms / Q000628:therapy*
D001500:BCG Vaccine