title: Current progress and challenges in ocular surface reconstruction using cultivated epithelial sheet transplantation.
abstract: The cultivated epithelial transplantation is a new surgical modality for treating a variety of severe ocular surface disorders. This type of tissue-engineered epithelial sheet provides a rapid epithelial coverage on the corneal surface that reduces inflammation and postoperative complications. Although cultivated corneal epithelial transplantation is an effective surgical strategy, autologous transplantation is limited to unilateral cases. Autologous cultivated oral mucosal epithelial transplantation (COMET) enables surgeons to reconstruct the ocular surface using autologous, non-ocular surface cells, and has opened a new pathway for treating severe, bilateral ocular surface disorders.
authors.affiliation: Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Inatomi
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: N
authors.initials: N
authors.lastname: Koizumi
authors.forename: C
authors.initials: C
authors.lastname: Sotozono
authors.forename: S
authors.initials: S
authors.lastname: Kinoshita
mesh_terms: D002478:Cells, Cultured; D003315:Cornea / Q000166:cytology / Q000473:pathology*; D003316:Corneal Diseases / Q000473:pathology / Q000601:surgery*; D004847:Epithelial Cells / Q000166:cytology* / Q000637:transplantation; D004848:Epithelium / Q000637:transplantation*; D005123:Eye / Q000473:pathology*; D005128:Eye Diseases / Q000601:surgery* / Q000628:therapy; D006801:Humans; D007249:Inflammation; D009061:Mouth Mucosa / Q000637:transplantation*; D013508:Ophthalmologic Surgical Procedures / Q000379:methods*; D010865:Pilot Projects; D019651:Plastic Surgery Procedures; D023822:Tissue Engineering / Q000379:methods*; D014182:Transplantation, Autologous