Dendritic cells in rhinitis.
Dendritic cells (DCs) play an important role in all kind of rhinitis and sinusitis. One of the most important upper airway diseases is allergic rhinitis. DCs are the professional antigen presenting cells that have the capacity to present antigen to naive-T cells and T-effector cells. In the context of a broad spectrum of rhinitis, from allergic rhinitis via upper respiratory tract virus infection to chronic sinusitis, DCs have an important role in the immunological outcome of the disease. Studies in humans and animal models that have highlighted the role of DC were evaluated. This article reviews recent information on the involvement of DC in rhinitis, and the mechanisms by which DC could be employed as targets for therapeutic intervention.
Kleinjan
Alex
A
Department of Pulmonary Medicine, Erasmus M.C, Dr. Molerwaterplein, Rotterdam, The Netherlands. a.kleinjan@erasmusmc.nl
Lambrecht
Bart N
BN
D000818:Animals; D017951:Antigen Presentation; D002465:Cell Movement; D018925:Chemokines / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D003713:Dendritic Cells / Q000187:drug effects / Q000276:immunology*; D020566:Dendritic Cells, Follicular / Q000276:immunology; D004195:Disease Models, Animal; D006801:Humans; D007108:Immune Tolerance; D018928:Immunity, Mucosal; D007167:Immunotherapy / Q000379:methods; D007801:Langerhans Cells / Q000276:immunology; D009297:Nasal Mucosa / Q000276:immunology; D012220:Rhinitis / Q000276:immunology* / Q000628:therapy
D018925:Chemokines; D016207:Cytokines