Gene expression profile in the peripheral blood of patients with prostate cancer and benign prostatic hyperplasia.
BACKGROUND
Prostate cancer consists of multifactorial and multifocal events, generating differential gene expression in tumor cells.


METHODS
The molecular profile of 14 gene expression was analyzed through cDNA array in blood samples of patients with prostate cancer (PCa) and benign prostatic hyperplasia (BPH).


RESULTS
Messenger RNA from patient's blood showed significant differences between PCa and BPH groups only for the NOS3 gene, with an occurrence chance for PCa5.8-fold higher than BPH disease.


CONCLUSIONS
The NOS3 gene expression in the patient's blood may be used as a putative biomarker for prostate cancer.
Alonso
Vivian
V
Neves
Adriana F
AF
Marangoni
Karina
K
Faria
Paula C B
PC
Freschi
Ana Paula P
AP
Capaneli
Andréia C
AC
Meola
Juliana
J
Goulart
Luiz R
LR
D000328:Adult; D015870:Gene Expression; D020869:Gene Expression Profiling; D052138:Genes, Neoplasm / Q000235:genetics; D006801:Humans; D008297:Male; D052250:Nitric Oxide Synthase Type III / Q000097:blood / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis; D011470:Prostatic Hyperplasia / Q000097:blood* / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000235:genetics*; D012333:RNA, Messenger / Q000097:blood / Q000235:genetics
D012333:RNA, Messenger; C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III