title: Morphology studies of the human fetal cochlea in turner syndrome.
abstract: OBJECTIVE
  Turner syndrome (TS) is the most frequent sex chromosome abnormality, and sensorineural hearing loss is common. We aimed to determine whether there are consistent morphologic cochlear abnormalities during gestational development that could be associated with TS.
  
  
  METHODS
  The histology of nine fetal temporal bones of TS autopsied after spontaneous abortion was studied.
  
  
  RESULTS
  Gross morphologic examination of the TS cochleae failed to reveal a pattern of structural abnormalities that would explain the development of sensorineural hearing loss. Mondini-like cochlear dysplasia was observed in one 13-wk-old TS fetus.
  
  
  CONCLUSIONS
  We could not demonstrate a consistent pattern of cochlear malformations.
authors.affiliation: Department of Otorhinolaryngology, Research Laboratories for Inner Ear Biology, University Hospital, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: John H
authors.initials: JH
authors.lastname: Fish
authors.forename: Ilona
authors.initials: I
authors.lastname: Schwentner
authors.forename: Joachim
authors.initials: J
authors.lastname: Schmutzhard
authors.forename: Irene
authors.initials: I
authors.lastname: Abraham
authors.forename: Andrea
authors.initials: A
authors.lastname: Ciorba
authors.forename: Alessandro
authors.initials: A
authors.lastname: Martini
authors.forename: Consolato
authors.initials: C
authors.lastname: Sergi
authors.forename: Anneliese
authors.initials: A
authors.lastname: Schrott-Fischer
authors.forename: Rudolf
authors.initials: R
authors.lastname: Glueckert
mesh_terms: D003051:Cochlea / Q000196:embryology*; D005333:Fetus / Q000002:abnormalities / Q000473:pathology*; D005865:Gestational Age; D006319:Hearing Loss, Sensorineural / Q000209:etiology*; D006801:Humans; D013701:Temporal Bone / Q000196:embryology; D014424:Turner Syndrome / Q000150:complications / Q000196:embryology* / Q000473:pathology*