Antifungal activity of anidulafungin, a product of Aspergillus nidulans, against Aspergillus nidulans.
Anidulafungin is a semisynthetic product originating from Aspergillus nidulans. The aim of this study was to determine whether this drug is active against A. nidulans strains. The minimum effective concentration (MEC) of anidulafungin without and with 50% foetal calf serum was determined according to the Clinical and Laboratory Standards microdilution method. All 13 A. nidulans strains were highly susceptible to anidulafungin, with a MEC of 0.031mg/L. The presence of serum did not affect the in vitro activity. In conclusion, chemical modification of the original echinocandin B moiety renders this natural product active against moulds, including A. nidulans.
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Institute of Medical Microbiology and Hygiene, University Clinic Mannheim, University of Heidelberg, Mannheim, Germany. herbert.hof@imh.ma.uni-heidelberg.de
Dietz
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D000077612:Anidulafungin; D000935:Antifungal Agents / Q000494:pharmacology*; D001233:Aspergillus nidulans / Q000187:drug effects*; D054714:Echinocandins / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
D000935:Antifungal Agents; D054714:Echinocandins; D000077612:Anidulafungin