Protective effect of Cox-2 allelic variants on risk of colorectal adenoma development in African Americans.
BACKGROUND
Recent evidence indicates that single nucleotide polymorphisms (SNPs) in the Cox-2 gene may modulate the risk of colorectal adenoma development.


METHODS
We explored possible associations between Cox-2 polymorphisms and risk of adenoma development in an African American case-control study comprising 72 cases of advanced adenomas and 146 polyp-free controls. An exhaustive approach of genotyping 13 haplotype-tagging SNPs (ht SNPs) distributed over the entire COX-2 gene was used.


RESULTS
Statistically significant inverse associations were observed between the heterozygous genotypes at the 5229 G>T polymorphism in intron 5 [odds ratio (OR)=0.42; confidence interval (CI)=0.19-0.92; p=0.03] and at the 10935 A>G polymorphism in the 3' flanking region downstream from the poly A signals (OR=0.39; CI=0.18-0.83;p=0.01) and the risk for colorectal adenoma development.


CONCLUSIONS
The data from our pilot study suggest that allelic variants of the COX-2 gene significantly influence the risk of adenoma development in the African American population.
Ashktorab
Hassan
H
Department of Medicine and Cancer Center, Howard University College of Medicine, Washington, D.C., USA.
Tsang
Shirley
S
Luke
Brian
B
Sun
Zhonghe
Z
Adam-Campbell
Lucile
L
Kwagyan
John
J
Poirier
Richard
R
Akter
Shahina
S
Akhgar
Ahmad
A
Smoot
Duane
D
Munroe
David J
DJ
Ali
Iqbal Unnisa
IU
D000236:Adenoma / Q000201:enzymology / Q000235:genetics*; D001741:Black or African American / Q000235:genetics*; D000483:Alleles; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000201:enzymology / Q000235:genetics*; D051546:Cyclooxygenase 2 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
D051546:Cyclooxygenase 2