T serotypes and antimicrobial susceptibilities of group A streptococcus isolates from pediatric pharyngotonsillitis.
Group A streptococcus (GAS) is a major cause of pediatric pharyngotonsillitis. In this study we determined the T serotype and antimicrobial susceptibility of GAS isolates from Japanese children. From January to December 2006, a total of 438 isolates of GAS were obtained from pharyngeal swabs of 438 children with pharyngotonsillitis. The commonest T serotype was type 1 (110 strains, 25.1%), followed by type 12 (107, 24.4%) and type 4 (77, 17.6%). All GAS isolated from pharyngeal swabs were susceptible to beta-lactams (benzylpenicillin, amoxicillin, cefotaxime, ceftriaxone, imipenem, panipenem, and cefditoren) and vancomycin, but 19.6, 19.6, 3.2, 11.6, and 27.6% were resistant to erythromycin, clarithromycin, clindamycin, minocycline, and norfloxacin, respectively. Resistance varied considerably with the T serotype. In particular, type 4 isolates had the highest resistance (67.5, 67.5, 26.0, and 53.2% were resistant to erythromycin, clarithromycin, minocycline, and norfloxacin, respectively).
Funahashi
Keiji
K
Department of Clinical Laboratory, Konan Kosei Hospital, Aichi, Japan. k-funahashi@konan.jaaikosei.or.jp
Nakane
Kazumasa
K
Yasuda
Naoko
N
Suzuki
Michio
M
Narita
Atsushi
A
Arai
Naoko
N
Ahn
Jaekun
J
Koyama
Noriko
N
Ushida
Hajime
H
Nishimura
Naoko
N
Ozaki
Takao
T
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D006801:Humans; D007223:Infant; D007564:Japan / Q000453:epidemiology; D008826:Microbial Sensitivity Tests; D010612:Pharyngitis / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology*; D012703:Serotyping; D013290:Streptococcal Infections / Q000276:immunology / Q000382:microbiology*; D013297:Streptococcus pyogenes / Q000145:classification* / Q000302:isolation & purification*; D014069:Tonsillitis / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology*
D000900:Anti-Bacterial Agents