title: Preattentive dysfunction in major depression: a magnetoencephalography study using auditory mismatch negativity.
abstract: Information processing deficits in major depressive disorder have been infrequently examined electrophysiologically. Its preattentive and sensory information processing was examined using mismatch field (MMNm) and P1m components, respectively, by magnetoencephalography. Fourteen major depressive disorder patients and 19 healthy volunteers participated in the study. MMNm was elicited in response to duration and frequency changes of pure-tone stimuli and in response to a vowel across-category change. The magnetic global field power (mGFP) of MMNm was significantly smaller in the major depressive disorder patients than in the healthy volunteers, although that of P1m did not differ between the two groups. Information processing at the preattentive level is impaired functionally in major depressive disorder, and this dysfunction is not due to the dysfunction at the lower level of information processing.
authors.affiliation: Department of Psychiatry and Human Behavior, Gunma University Graduate School of Medicine, Gunma, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Takei
authors.forename: Sumie
authors.initials: S
authors.lastname: Kumano
authors.forename: Suguru
authors.initials: S
authors.lastname: Hattori
authors.forename: Toru
authors.initials: T
authors.lastname: Uehara
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kawakubo
authors.forename: Kiyoto
authors.initials: K
authors.lastname: Kasai
authors.forename: Masato
authors.initials: M
authors.lastname: Fukuda
authors.forename: Masahiko
authors.initials: M
authors.lastname: Mikuni
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D001288:Attention / Q000502:physiology*; D001307:Auditory Perception / Q000502:physiology; D003865:Major Depressive Disorder / Q000523:psychology*; D005260:Female; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D008606:Mental Processes / Q000502:physiology; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011597:Psychomotor Performance / Q000502:physiology; D014796:Visual Perception / Q000502:physiology