title: Low-dose naltrexone for disease prevention and quality of life.
abstract: The use of low-dose naltrexone (LDN) for the treatment and prophylaxis of various bodily disorders is discussed. Accumulating evidence suggests that LDN can promote health supporting immune-modulation which may reduce various oncogenic and inflammatory autoimmune processes. Since LDN can upregulate endogenous opioid activity, it may also have a role in promoting stress resilience, exercise, social bonding, and emotional well-being, as well as amelioration of psychiatric problems such a autism and depression. It is proposed that LDN can be used effectively as a buffer for a large variety of bodily and mental ailments through its ability to beneficially modulate both the immune system and the brain neurochemistries that regulate positive affect.
authors.affiliation: Department of Humanities and Social Sciences, Embry-Riddle Aeronautical University, Daytona Beach, FL 32114, United States. NPHbrown@aol.com
authors.forename: Norman
authors.initials: N
authors.lastname: Brown
authors.forename: Jaak
authors.initials: J
authors.lastname: Panksepp
mesh_terms: D016207:Cytokines / Q000276:immunology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000517:prevention & control*; D018448:Models, Immunological; D009271:Naltrexone / Q000008:administration & dosage*; D009292:Narcotic Antagonists / Q000008:administration & dosage; D009369:Neoplasms / Q000276:immunology* / Q000517:prevention & control*; D011788:Quality of Life
chemical_list: D016207:Cytokines; D009292:Narcotic Antagonists; D009271:Naltrexone