Anti-Ro antibody and cutaneous vasculitis in systemic lupus erythematosus.
Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease with various clinical and serological manifestations. Previous studies have shown the association of SLE and anti-Ro antibody with a series of clinical manifestations. We investigated this association in Brazilian patients with SLE. Five hundred and nine consecutive patients who fulfilled the revised American College of Rheumatology criteria for the SLE were enrolled in the study from June to December 2007. All patients were from our Service of Rheumatology, School of Medicine, University of São Paulo, Brazil. Frequencies of a series of laboratorial and clinical manifestations were calculated. Anti-Ro antibody was associated to anti-La antibody, female, and cutaneous vasculitis. In multivariate analysis, patients with anti-Ro antibody has 1.63 (95% CI 1.07-2.50) more risk to develop cutaneous vasculitis than patients without this antibody. Our data have demonstrated that anti-Ro antibody is an independent useful serologic marker for cutaneous vasculitis.
Fukuda
Márcio Veronesi
MV
Division of Rheumatology, School of Medicine, University of São Paulo, Av. Dr. Arnaldo, 455, Sala 3133, CEP 01246-903, São Paulo, Brazil.
Lo
Simone Chinwa
SC
de Almeida
Cláudia Salvini
CS
Shinjo
Samuel Katsuyuki
SK
D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood*; D001938:Brazil / Q000453:epidemiology; D015897:Comorbidity; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology / Q000276:immunology* / Q000473:pathology; D008297:Male; D012189:Retrospective Studies; D012737:Sex Factors; D017445:Skin Diseases, Vascular / Q000453:epidemiology / Q000276:immunology* / Q000473:pathology
D000974:Antibodies, Antinuclear; C035356:SS-A antibodies