Asymmetric, catalytic, and direct self-aldol reaction of acetaldehyde catalyzed by diarylprolinol.
An asymmetric, catalytic, and direct self-aldol reaction of acetaldehyde was catalyzed by diarylprolinol in NMP, affording the trimer acetal, which was generated by the reaction of the self-aldol product with another acetaldehyde molecule in a moderate yield with good enantioselectivity. Acetal is the synthetic equivalent of the self-aldol product, which can be converted into other synthetically useful compounds in one pot without compromising the enantioselectivity.
Hayashi
Yujiro
Y
Department of Industrial Chemistry, Faculty of Engineering, and Research Institute for Science and Technology, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan. hayashi@ci.kagu.tus.ac.jp
Samanta
Sampak
S
Itoh
Takahiko
T
Ishikawa
Hayato
H