Antibacterial novel phenolic diterpenes from Podocarpus macrophyllus D. Don.
Two new sempervirol type diterpenes, inumakiols A, B, and six new totarol type diterpenes, inumakiols C-H, were isolated from a methanolic extract of bark of Podocarpus macrophyllus (Podocarpaceae), along with one known abietane, two known totarol type diterpenes, and one known totarol type diterpene dimer. The structures of the new compounds were elucidated by the spectroscopic methods. Some of them possessed antibacterial activity against oral pathogenic microorganisms with minimum inhibitory concentration (MIC) values ranging from 3.1 to 25 ppm.
Sato
Kimihiko
K
School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo, Japan.
Sugawara
Keito
K
Takeuchi
Hirono
H
Park
Hyun-Sun
HS
Akiyama
Toshiyuki
T
Koyama
Tetsuo
T
Aoyagi
Yutaka
Y
Takeya
Koichi
K
Tsugane
Takanori
T
Shimura
Susumu
S
D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D009055:Mouth / Q000382:microbiology; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D010944:Plants / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000900:Anti-Bacterial Agents; D004224:Diterpenes; D010936:Plant Extracts; C534248:inumakiol A; C534249:inumakiol B