Angiotensin II receptor 1 involved in the central pressor response induced by interleukin-1 beta in the paraventricular nucleus.
OBJECTIVE
To investigate the possible participation of angiotensin II receptor 1 (AT(1) receptor) in pressor response induced by IL-1beta in the paraventricular nucleus (PVN) of hypothalamus.


METHODS
The experiments were performed on adult Wistar rats. Mean arterial pressure (MAP) were recorded during microinjection of different doses of IL-1beta, IL-1beta together with Losartan, an AT1 receptor antagonist, or Ang II pre-treated with IL-1beta into PVN. Rats microinjected with saline were served as controls in all experiments.


RESULTS
Microinjection of IL-1beta (0.1 or 0.2 ng) resulted in increases in blood pressure in a dose-dependent manner, and the pressor effect caused by administration of IL-1beta (0.2 ng) could be attenuated by pre-treatment with AT(1) receptor antagonist (100 ng Losartan). A subpressor dose of IL-1beta (0.05 ng) could augment the pressor response induced by microinjection of Ang II (10 ng).


CONCLUSIONS
The present results provide support that central infusion of IL-1beta increases blood pressure and the pressor response requires stimulation of AT(1) receptors. It is also shown that IL-1beta has the effect of increasing the magnitude of pressor response induced by Ang II in PVN.
Lu
Yang
Y
Department of Physiology, School of Basic Medical Sciences, Jilin University, Jilin, China.
Chen
Jianguang
J
Yin
Xiaohua
X
Zhao
Hua
H
D000704:Analysis of Variance; D047228:Angiotensin II Type 1 Receptor Blockers / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D053583:Interleukin-1beta / Q000494:pharmacology*; D019808:Losartan / Q000494:pharmacology; D008297:Male; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D044140:Receptor, Angiotensin, Type 1 / Q000378:metabolism*; D013997:Time Factors
D047228:Angiotensin II Type 1 Receptor Blockers; D053583:Interleukin-1beta; D044140:Receptor, Angiotensin, Type 1; D019808:Losartan