title: Effect of intraoperative magnesium sulphate infusion on pain relief after laparoscopic cholecystectomy.
abstract: BACKGROUND
  The aim of the study is to evaluate the analgesic efficiency of perioperative magnesium sulphate infusion in patients undergoing laparoscopic cholecystectomy (LC).
  
  
  METHODS
  In a randomized, double-blind trial study, 83 patients were divided into two groups. Group MT received 50 mg/kg i.v. magnesium sulphate in 100 ml of 0.9% normal saline and Group T received the same volume of isotonic saline during the intraoperative period. The cumulative post-operative tramadol consumption was measured to assess the analgesic effect using a patient-controlled analgesia device. Pain intensities at rest and while coughing were evaluated at 0, 2, 4, 8, 12, and 24 h post-operatively.
  
  
  RESULTS
  The pain scores in Group MT were significantly lower than Group T at 0, 4, and 12 h post-operatively. The average of visual analogue scale at rest and during cough during 24 h post-operatively was found to be statistically significant between groups. The total dose of tramadol the 24-h period in Group MT and Group T was found to be 281.34 +/- 90.82 and 317.46 +/- 129.59, respectively.
  
  
  CONCLUSIONS
  Per-operative 50 mg/kg magnesium sulphate infusion is effective in reducing post-operative pain in patients undergoing LC.
authors.affiliation: Department of General Surgery, Gülhane Military Medical Faculty, Ankara, Turkey. onermentes@yahoo.com
authors.forename: O
authors.initials: O
authors.lastname: Mentes
authors.forename: A
authors.initials: A
authors.lastname: Harlak
authors.forename: T
authors.initials: T
authors.lastname: Yigit
authors.forename: A
authors.initials: A
authors.lastname: Balkan
authors.forename: M
authors.initials: M
authors.lastname: Balkan
authors.forename: A
authors.initials: A
authors.lastname: Cosar
authors.forename: A
authors.initials: A
authors.lastname: Savaser
authors.forename: O
authors.initials: O
authors.lastname: Kozak
authors.forename: T
authors.initials: T
authors.lastname: Tufan
mesh_terms: D016058:Analgesia, Patient-Controlled; D000700:Analgesics / Q000008:administration & dosage*; D017081:Cholecystectomy, Laparoscopic / Q000009:adverse effects*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007430:Intraoperative Care / Q000379:methods; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D014147:Tramadol / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D000700:Analgesics; D014147:Tramadol; D008278:Magnesium Sulfate