Choleretic activity of 2-demethoxycarbonyl-2-ethoxycarbonyl-11-deoxymisoprostol on the model of CCl4-induced hepatitis.
Therapeutic administration of 11-deoxymisoprostol had a hepatoprotective effect, which manifested in a decrease in the content of alanine transaminase and aspartate transaminase in blood plasma, and produced a choleretic effect in rats with CCI4-induced toxic hepatitis.
Sapozhnikova
T A
TA
Laboratory of New Medicinal Agents, Institute of Organic Chemistry, Ufa Research Center of the Russian Academy of Sciences, Ufa.
Zarudii
F S
FS
Baschenko
N Zh
NZh
Gabdrahmanova
S F
SF
Makara
N S
NS
Khisamutdinova
R Yu
RY
Ivanova
N A
NA
Nazarov
V S
VS
D000818:Animals; D001646:Bile / Q000378:metabolism; D002251:Carbon Tetrachloride / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000473:pathology; D002756:Cholagogues and Choleretics / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D016595:Misoprostol / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
C475855:2-demethoxycarbonyl-2-ethoxycarbonyl-11-deoxymisoprostol; D002756:Cholagogues and Choleretics; D016595:Misoprostol; D002251:Carbon Tetrachloride