title: Convenient one-pot synthesis of 2-oxazolines from carboxylic acids.
abstract: Simple one-pot methods for preparation of 2-oxazolines have been developed using 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM). Treatment of a mixture of carboxylic acids and 2-haloethylammonium salts with DMT-MM in methanol followed by refluxing in the presence of KOH gives oxazolines.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Chuo-ku, Koba, Japan.
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Hioki
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Takechi
authors.forename: Noriyo
authors.initials: N
authors.lastname: Kimura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Munetaka
authors.initials: M
authors.lastname: Kunishima
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry*; D006878:Hydroxides; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D000432:Methanol; D010080:Oxazoles / Q000138:chemical synthesis*; D017680:Potassium Compounds; D013055:Spectrophotometry, Infrared
chemical_list: D002264:Carboxylic Acids; D006878:Hydroxides; D007202:Indicators and Reagents; D010080:Oxazoles; D017680:Potassium Compounds; C029943:potassium hydroxide; D000432:Methanol