title: Recombinant canine coronaviruses related to transmissible gastroenteritis virus of Swine are circulating in dogs.
abstract: Four canine coronavirus type II (CCoV-II) strains were identified in the guts and internal organs of pups which had died of acute gastroenteritis. The CCoV-II strains were strictly related to porcine transmissible gastroenteritis virus (TGEV) in the N-terminal domain of the spike protein, whereas in the other parts of the genome, a higher genetic relatedness to recent CCoV-II isolates was observed. Experimental infection of dogs with a TGEV-like isolate induced mild gastroenteritis without any systemic involvement. By virus neutralization tests, antigenic differences between reference and TGEV-like CCoVs were found. Our data support the potential recombinant origin of the TGEV-like CCoVs.
authors.affiliation: Department of Public Health and Animal Sciences, Faculty of Veterinary Medicine, Valenzano (Bari), Italy. n.decaro@veterinaria.uniba.it
authors.forename: Nicola
authors.initials: N
authors.lastname: Decaro
authors.forename: Viviana
authors.initials: V
authors.lastname: Mari
authors.forename: Marco
authors.initials: M
authors.lastname: Campolo
authors.forename: Alessio
authors.initials: A
authors.lastname: Lorusso
authors.forename: Michele
authors.initials: M
authors.lastname: Camero
authors.forename: Gabriella
authors.initials: G
authors.lastname: Elia
authors.forename: Vito
authors.initials: V
authors.lastname: Martella
authors.forename: Paolo
authors.initials: P
authors.lastname: Cordioli
authors.forename: Luis
authors.initials: L
authors.lastname: Enjuanes
authors.forename: Canio
authors.initials: C
authors.lastname: Buonavoglia
mesh_terms: D000818:Animals; D001483:Base Sequence; D017934:Coronavirus / Q000145:classification / Q000235:genetics / Q000502:physiology*; D004279:DNA, Viral; D004283:Dog Diseases / Q000821:virology*; D004285:Dogs; D005761:Gastroenteritis, Transmissible, of Swine / Q000635:transmission* / Q000821:virology; D008969:Molecular Sequence Data; D010802:Phylogeny; D011995:Recombination, Genetic; D012689:Sequence Homology, Nucleic Acid
chemical_list: D004279:DNA, Viral