title: A sparse PLS for variable selection when integrating omics data.
abstract: Recent biotechnology advances allow for multiple types of omics data, such as transcriptomic, proteomic or metabolomic data sets to be integrated. The problem of feature selection has been addressed several times in the context of classification, but needs to be handled in a specific manner when integrating data. In this study, we focus on the integration of two-block data that are measured on the same samples. Our goal is to combine integration and simultaneous variable selection of the two data sets in a one-step procedure using a Partial Least Squares regression (PLS) variant to facilitate the biologists' interpretation. A novel computational methodology called ;;sparse PLS" is introduced for a predictive analysis to deal with these newly arisen problems. The sparsity of our approach is achieved with a Lasso penalization of the PLS loading vectors when computing the Singular Value Decomposition. Sparse PLS is shown to be effective and biologically meaningful. Comparisons with classical PLS are performed on a simulated data set and on real data sets. On one data set, a thorough biological interpretation of the obtained results is provided. We show that sparse PLS provides a valuable variable selection tool for highly dimensional data sets.
authors.affiliation: INRA UR 631, Université de Toulouse. k.lecao@imb.uq.edu.au
authors.forename: Kim-Anh
authors.initials: KA
authors.lastname: Lê Cao
authors.forename: Debra
authors.initials: D
authors.lastname: Rossouw
authors.forename: Christèle
authors.initials: C
authors.lastname: Robert-Granié
authors.forename: Philippe
authors.initials: P
authors.lastname: Besse
mesh_terms: D000818:Animals; D001699:Biometry / Q000379:methods*; D003627:Data Interpretation, Statistical; D005285:Fermentation / Q000235:genetics; D020869:Gene Expression Profiling / Q000706:statistics & numerical data; D023281:Genomics / Q000706:statistics & numerical data; D016018:Least-Squares Analysis; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D055432:Metabolomics / Q000706:statistics & numerical data; D015999:Multivariate Analysis; D040901:Proteomics / Q000706:statistics & numerical data; D051381:Rats; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D014116:Toxicology / Q000706:statistics & numerical data