Melamine and cyanuric acid-induced crystalluria, uroliths, and nephrotoxicity in dogs and cats.
This article discusses the 2007 recall of canned pet food because of concerns about adverse effects on kidney function of cats and dogs. The discovery of melamine and cyanuric acid in the foods is detailed. Case studies, including clinical, pathology, histology, and toxicology findings, are presented. An attempt is being made to identify the minerals in the uroliths and kidney tissues of affected animals.
Osborne
Carl A
CA
Veterinary Clinical Sciences Department, Minnesota Urolith Center, College of Veterinary Medicine, University of Minnesota, 1352 Boyd Avenue, St. Paul, MN 55108, USA. osbor002@umn.edu
Lulich
Jody P
JP
Ulrich
Lisa K
LK
Koehler
Lori A
LA
Albasan
Hasan
H
Sauer
Linda
L
Schubert
Gernot
G
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000473:pathology / Q000652:urine / Q000662:veterinary*; D000821:Animal Feed / Q000032:analysis; D000818:Animals; D002371:Cat Diseases / Q000139:chemically induced* / Q000473:pathology / Q000652:urine; D002415:Cats; D003460:Crystallization; D004283:Dog Diseases / Q000139:chemically induced* / Q000473:pathology / Q000652:urine; D004285:Dogs; D005260:Female; D005506:Food Contamination / Q000032:analysis*; D008297:Male; D014227:Triazines / Q000032:analysis / Q000633:toxicity* / Q000652:urine; D052878:Urolithiasis / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*
D014227:Triazines; C004632:cyanuric acid; C011907:melamine