Diabetes and atherosclerosis: is there a role for hyperglycemia?
Atherosclerosis is accelerated in both type 1 and type 2 diabetes. The hallmark of diabetes is the presence of hyperglycemia. In this article, we review the role of glucose in the pathogenesis of atherosclerosis. Evidence obtained from epidemiological, in vitro, and animal studies will be reviewed in an attempt to understand the complex relationship between hyperglycemia and cardiovascular risk that is emerging from clinical trials.
Chait
Alan
A
Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington School of Medicine, Seattle, WA 98109, USA. achait@u.washington.edu
Bornfeldt
Karin E
KE
D000818:Animals; D050197:Atherosclerosis / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D002986:Clinical Trials as Topic; D048909:Diabetes Complications / Q000097:blood / Q000453:epidemiology; D005947:Glucose / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D050356:Lipid Metabolism
D005947:Glucose