Obesity genes: so close and yet so far...
Little is known about genetic variants that predispose individuals toward leanness or fatness. This minireview highlights recent advances in the study of human populations, animal models and synergistic efforts as described by De Luca and colleagues in BMC Genetics, which are beginning to harvest low-hanging fruit in the search for obesity genes.
Pomp
Daniel
D
Departments of Nutrition, Cell and Molecular Physiology, University of North Carolina, Chapel Hill, NC 27599-7461, USA. dpomp@unc.edu
Mohlke
Karen L
KL
D000818:Animals; D001823:Body Composition / Q000235:genetics; D015992:Body Mass Index; D002874:Chromosome Mapping; D020022:Genetic Predisposition to Disease; D023281:Genomics; D006801:Humans; D023421:Models, Animal; D009765:Obesity / Q000235:genetics*