Emerging viruses in transplantation: there is more to infection after transplant than CMV and EBV.
Transplant physicians and surgeons are familiar with the risks, clinical behavior, and management of cytomegalovirus in transplant recipients. Donor-transmitted viral infections are uncommon but in recent years have brought to light the clinical manifestations of rabies, West Nile virus, and lymphocytic choriomeningitis virus in the early posttransplant period. Later posttransplant, infection with viruses circulating in the community can occur with a number of pathogens, including some vaccine-preventable illnesses such as measles and mumps. Recent advances in molecular microbiology have made it possible to diagnose a growing number of community-acquired viral pathogens infecting transplant recipients. This article reviews some of the emerging and reemerging viral pathogens infecting solid organ and hematopoietic stem-cell recipients, including adenovirus, bocavirus, coronavirus, human herpesvirus-6, lymphocytic choriomeningitis virus, measles, mumps, metapneumovirus, parainfluenza, rotavirus, respiratory syncytial virus, and West Nile virus.
Fischer
Staci A
SA
Division of Infectious Diseases, Department of Transplant Services, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI 02903, USA. sfischer@lifespan.org
D000998:Antiviral Agents / Q000627:therapeutic use*; D018352:Coronavirus Infections / Q000453:epidemiology / Q000517:prevention & control; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000517:prevention & control; D004417:Dyspnea / Q000209:etiology / Q000821:virology; D020031:Epstein-Barr Virus Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000517:prevention & control; D005334:Fever / Q000209:etiology / Q000821:virology; D006261:Headache / Q000209:etiology / Q000821:virology; D006801:Humans; D010322:Parvoviridae Infections / Q000453:epidemiology / Q000517:prevention & control; D011183:Postoperative Complications / Q000188:drug therapy / Q000453:epidemiology / Q000821:virology*; D012307:Risk Factors; D014180:Transplantation / Q000009:adverse effects*; D014777:Virus Diseases / Q000188:drug therapy / Q000453:epidemiology*
D000998:Antiviral Agents