Vitiligo following a combined liver-kidney transplant.
We report an Afro-Caribbean male who developed vitiligo 10 days following a combined liver-kidney transplant from a Caucasian donor. Neither the donor nor the recipient had any previous history of vitiligo, nor of autoimmunity. The depigmentation gradually resolved by 8 weeks post-transplant with topical corticosteroids and standard maintenance immunosuppression. We propose that the skin depigmentation occurred due to the destruction of melanocytes by donor-derived alloreactive cytotoxic T-lymphocytes or antibody transferred during transplantation. Although vitiligo has been described in patients receiving allogeneic bone marrow transplantation for haematological malignancy, there are no previous reports of vitiligo post-solid organ transplantation.
Bradley
Victoria
V
Cambridge School of Clinical Medicine, University of Sheffield, UK.
Kemp
Elizabeth Helen
EH
Dickinson
Claire
C
Key
Tim
T
Gibbs
Paul
P
Clatworthy
Menna R
MR
D015551:Autoimmunity; D006801:Humans; D007518:Isoantibodies / Q000378:metabolism; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000276:immunology; D016031:Liver Transplantation / Q000009:adverse effects* / Q000276:immunology; D008297:Male; D008544:Melanocytes / Q000276:immunology; D008875:Middle Aged; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000637:transplantation; D013997:Time Factors; D014019:Tissue Donors; D014820:Vitiligo / Q000209:etiology* / Q000276:immunology
D007518:Isoantibodies