title: Synthesis of indene derivatives via electrophilic cyclization.
abstract: 3-Iodo-1H-indene derivatives are synthesized by iodonium-promoted 5-endo-dig carbocyclization of 2-substituted ethynylmalonates. Various 2-substituted ethynylmalonates bearing aryl-, alkyl- and ether-protected propargyl alcohols were successfully converted to cyclized products. Their use in subsequent reactions as substrate and catalyst was investigated.
authors.affiliation: School of Chemistry, Cardiff University, Park Place, Cardiff CF10 3AT, UK.
authors.forename: Zulfiqar Ali
authors.initials: ZA
authors.lastname: Khan
authors.forename: Thomas
authors.initials: T
authors.lastname: Wirth
mesh_terms: D003500:Cyclization; D007192:Indenes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D007192:Indenes