title: Peritoneal dialysis for chronic renal failure in a patient with methylmalonic acidaemia.
abstract: Chronic renal failure is a common complication of methylmalonic acidaemia (MMA). It is usually managed with haemodialysis and renal transplantation. We report the use of continuous cycling peritoneal dialysis (CCPD) for 20 months in a paediatric patient with chronic renal failure due to MMA. This procedure resulted in the elimination of 950 micromol methylmalonate (MM) per day and a fall in the plasma MM concentration from 3.9 to 0.74 mmol/l. As a result of this treatment, the frequency at which this patient was hospitalised was markedly reduced prior to a successful renal transplantation.
authors.affiliation: Department of Nephrology, Royal Liverpool Children's Hospital, Liverpool, UK.
authors.forename: Bemigho
authors.initials: B
authors.lastname: Etuwewe
authors.forename: Caroline A
authors.initials: CA
authors.lastname: Jones
authors.forename: Shipra
authors.initials: S
authors.lastname: Mathur
authors.forename: Katherine P
authors.initials: KP
authors.lastname: Wright
authors.forename: Andrew A M
authors.initials: AA
authors.lastname: Morris
mesh_terms: D000592:Amino Acid Metabolism, Inborn Errors / Q000378:metabolism / Q000628:therapy*; D006801:Humans; D007223:Infant; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000628:therapy*; D016030:Kidney Transplantation; D008297:Male; D008764:Methylmalonic Acid / Q000378:metabolism*; D010530:Peritoneal Dialysis
chemical_list: D008764:Methylmalonic Acid