Asymmetric sulfur ylide based enantioselective synthesis of D-erythro-sphingosine.
An asymmetric sulfur ylide reaction was employed to prepare an epoxide intermediate in a convergent manner. This epoxide was efficiently transformed into D-erythro-sphingosine.
Morales-Serna
José Antonio
JA
Departamento de Química Analítica y Química Orgánica, Universitat Rovira i Virgili, C/Marcel.li Domingo s/n, 43007 Tarragona, Spain.
Llaveria
Josep
J
Díaz
Yolanda
Y
Matheu
M Isabel
MI
Castillón
Sergio
S
D006801:Humans; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism; D013379:Substrate Specificity
C481931:erythro-(2R,3S)-sphingosine; D013110:Sphingosine