Cross-talk between lung and systemic circulation during carbon nanotube respiratory exposure. Potential biomarkers.
Nanotechnology is an emerging field that demands urgent development of adequate toxicology and risk assessment. The previous experimental data on carbon nanotube respiratory exposure strongly suggest the need for complex evaluation of potential toxicity. Our work demonstrates that after carbon nanotube deposition in the lung, acute local and systemic responses are activated and characterized by a blood gene and protein expression signature. The approach described here will foster the development of biomarkers for application in human screening of nanoparticle exposure.
Erdely
Aaron
A
Toxicology and Molecular Biology Branch and Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA.
Hulderman
Tracy
T
Salmen
Rebecca
R
Liston
Angie
A
Zeidler-Erdely
Patti C
PC
Schwegler-Berry
Diane
D
Castranova
Vincent
V
Koyama
Shozo
S
Kim
Yoong-Ahm
YA
Endo
Morinobu
M
Simeonova
Petia P
PP
D000280:Administration, Inhalation; D000818:Animals; D015415:Biomarkers; D001798:Blood Proteins / Q000032:analysis*; D004781:Environmental Exposure / Q000032:analysis*; D005240:Feasibility Studies; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D037742:Nanotubes, Carbon / Q000032:analysis* / Q000737:chemistry*; D052638:Particulate Matter / Q000008:administration & dosage* / Q000493:pharmacokinetics*
D015415:Biomarkers; D001798:Blood Proteins; D037742:Nanotubes, Carbon; D052638:Particulate Matter