title: Can positron emission tomography facilitate paediatric drug development?
abstract: Advances in paediatric clinical pharmacology are interdependent with a better understanding of the influence of growth on drug disposition and action. In this field, there is an increasing need for non-invasive drug monitoring approaches. This paper aims to discuss the role of positron emission tomography in such practice. This molecular imaging technique enables the determination of the distribution of a drug radiolabelled with a positron-emitting radionuclide. Able to directly assess both pharmacokinetic and pharmacodynamic events in humans, positron emission tomography provides a new perspective on paediatric drug research. Although placing this technique in a unique position to potentially contribute to the process of drug development and evaluation in paediatrics, several ethical and methodological aspects should be considered.
authors.affiliation: PET Department, CERMEP-Imagerie du Vivant, Lyon, France. zimmer@univ-lyon1.fr
authors.forename: Luc
authors.initials: L
authors.lastname: Zimmer
mesh_terms: D002648:Child; D002657:Child Development; D002986:Clinical Trials as Topic; D055808:Drug Discovery; D054796:Drug Dosage Calculations; D016903:Drug Monitoring; D006801:Humans; D010372:Pediatrics / Q000941:ethics / Q000379:methods*; D010599:Pharmacokinetics; D049268:Positron-Emission Tomography / Q000941:ethics