Synthesis and antimycobacterial activity of selected nitrobenzyloxylated benzotriazoles.
A series of 1-nitrobenzyloxybenzotriazoles was prepared by the benzylation of the respective halogenosubstituted 1-hydroxybenzotriazoles. The newly obtained compounds were tested against four Mycobacterium strains. Particularly high antimycobacterial activity, comparable with that of isoniazide, was found for 5,6-dichloro- 1-(3,5-dinitrobenzyloxy)- 1H-benzotriazole.
Augustynowicz-Kopeć
Ewa
E
National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland.
Zwolska
Zofia
Z
Orzeszko
Andrzej
A
Kazimierczuk
Zygmunt
Z
D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000995:Antitubercular Agents; D014230:Triazoles