title: Predictors of olfactory dysfunction in patients with chronic rhinosinusitis.
abstract: OBJECTIVE
  To measure the prevalence of and identify clinical characteristics associated with poor olfactory function in a large cohort of patients with chronic rhinosinusitis (CRS).
  
  
  METHODS
  Multi-institutional, cross sectional analysis.
  
  
  METHODS
  An objective measure of olfactory dysfunction, the Smell Identification Test, demographic data, clinical factors, and comorbidity data were collected from a cohort of 367 patients who presented with CRS at three tertiary care centers. Data were analyzed using univariate and multivariate analyses.
  
  
  RESULTS
  Sixty-four percent of men and women aged 18 to 64 had olfactory dysfunction whereas 95% of patients older than or equal to 65 years had olfactory dysfunction (P < .001); no significant difference was noted by gender. By multivariate logistic regression analysis, patients with nasal polyposis [Odds ratio (OR) 2.4, 95% confidence interval (CI) 1.3-4.2, P = .003] and patients older than or equal to 65 years (OR 10.0, 95% CI 2.3-43.7, P = .002) were at increased risk of hyposmia. Patients with nasal polyposis (OR 13.2, 95% CI 5.7-30.7, P < .001), asthma (OR 4.2, 95% CI 1.8-9.8, P = .001), older than or equal to 65 years (OR 15.6, 95% CI 2.3-104.9, P = .005), and smokers (OR 7.6, 95% CI 1.8-31.6, P = .005) were at increased risk of anosmia.
  
  
  CONCLUSIONS
  Poor olfactory function is common in patients with CRS. Age, nasal polyposis, smoking, and asthma were significantly associated with olfactory dysfunction in patients with CRS. Neither prior endoscopic sinus surgery nor a history of allergic rhinitis was associated with olfactory dysfunction. Septal deviation and inferior turbinate hypertrophy were associated with normal olfactory function.
authors.affiliation: Division of Rhinology and Sinus Surgery, Oregon Sinus Center, Oregon Health and Science University, Portland, OR 97239, USA.
authors.forename: Jamie R
authors.initials: JR
authors.lastname: Litvack
authors.forename: Karen
authors.initials: K
authors.lastname: Fong
authors.forename: Jess
authors.initials: J
authors.lastname: Mace
authors.forename: Kenneth E
authors.initials: KE
authors.lastname: James
authors.forename: Timothy L
authors.initials: TL
authors.lastname: Smith
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D015331:Cohort Studies; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000150:complications / Q000175:diagnosis / Q000401:mortality; D000857:Olfaction Disorders / Q000453:epidemiology / Q000209:etiology*; D009922:Oregon; D012220:Rhinitis / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D012307:Risk Factors; D012852:Sinusitis / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D055815:Young Adult