[Clinical and morphological features of gastric and duodenal lesions in patients with chronic hepatitis].
Clinical presentation, endoscopic picture and morphological changes of gastric and duodenal mucosa were evaluated in 75 patients with chronic hepatitis of different (viral and non-viral) etiology. Endoscopic, morphological, and immunohistochemical studies revealed deterioration of morphometric characteristics of somatostatin-immunopositive epitheliocytes in gastric mucosa and their improvement in epitheliocytes producing endothelin-1 and nitric oxide synthase. These changes were associated with decreased proliferative activity and enhanced apoptosis of epitheliocytes in gastric mucosa.
Kozlova
I V
IV
Safonova
M V
MV
D000328:Adult; D017209:Apoptosis; D049109:Cell Proliferation; D004378:Duodenal Diseases / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D016099:Endoscopy, Gastrointestinal; D019332:Endothelin-1 / Q000096:biosynthesis; D005260:Female; D006521:Hepatitis, Chronic / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology; D008297:Male; D019001:Nitric Oxide Synthase / Q000096:biosynthesis; D011379:Prognosis; D012720:Severity of Illness Index; D013272:Stomach Diseases / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism
D019332:Endothelin-1; D019001:Nitric Oxide Synthase