title: Curcuminoids modulates oxidative damage and mitochondrial dysfunction in diabetic rat brain.
abstract: Diabetes exacerbates neuronal injury induced by hyperglycemia mediated oxidative damage and mitochondrial dysfunction. The aim of the present study is to investigate the effects of curcuminoids, polyphenols of Curcuma longa (L.) on oxidative stress and mitochondrial impairment in the brain of streptozotocin (STZ)-induced diabetic rats. A marked increase in lipid peroxidation and nitrite levels with simultaneous decrease in endogenous antioxidant marker enzymes was observed in the diabetic rat brain, which was restored to normal levels on curcuminoids treatment. Down-regulation of mitochondrial complex I and IV activity caused by STZ induction was also up-regulated on oral administration of curcuminoids. Moreover, curcuminoids administration profoundly elevated the ATP level, which was earlier reduced in the diabetic brain. These results suggest that curcuminoids exhibit a protective effect by accelerating antioxidant defense mechanisms and attenuating mitochondrial dysfunction in the brain of diabetic rats. Curcuminoids thus may be used as a promising therapeutic agent in preventing and/or delaying the progression of diabetic complications in the brain.
authors.affiliation: Centre for Advanced Research in Indian System of Medicine, SASTRA University, Thanjavur, Tamilnadu, India.
authors.forename: Manisha
authors.initials: M
authors.lastname: Rastogi
authors.forename: Rudra P
authors.initials: RP
authors.lastname: Ojha
authors.forename: G V
authors.initials: GV
authors.lastname: Rajamanickam
authors.forename: Aruna
authors.initials: A
authors.lastname: Agrawal
authors.forename: Abha
authors.initials: A
authors.lastname: Aggarwal
authors.forename: G P
authors.initials: GP
authors.lastname: Dubey
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D030024:Curcuma / Q000737:chemistry; D003474:Curcumin / Q000031:analogs & derivatives / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000378:metabolism*; D005419:Flavonoids / Q000494:pharmacology*; D015227:Lipid Peroxidation; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology*; D009573:Nitrites / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D010636:Phenols / Q000494:pharmacology*; D059808:Polyphenols; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin
chemical_list: D005419:Flavonoids; D009573:Nitrites; D010636:Phenols; D059808:Polyphenols; D013311:Streptozocin; D003474:Curcumin