[Co-expression and prognostic significance of hnRNP B1 and CD44 in non-small cell lung cancers].
OBJECTIVE
To study the co-expression and prognostic significance of hnRNP B1 and CD44 in non-small cell lung cancers (NSCLC).


METHODS
The co-expressions of CD44 and hnRNP B1 in the tissues from 88 cases of NSCLC were measured by immunohistochemistry. The relationship between the expressions and the prognosis of NSCLC was analysed.


RESULTS
The NSCLC had a high expression of hnRNP B1 (68.18%) and CD44 (52.27%). The cells had the longest average life [(59.607 +/- 4.092) months] in the conditions of high expressed hnRNP B1 and low expressed CD44, and shortest average life [(21.357 +/- 3.545) months] in the conditions of low expressed hnRNP B1 and high expressed CD44.


CONCLUSIONS
Combined detection of hnRNP B1 and CD44 can help forecast the prognosis of NSCLC.
Deng
Tai-bing
TB
Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Li
Wei-min
WM
Mo
Xian-ming
XM
Liu
Lun-xu
LX
Liu
Dan
D
Pu
Rong
R
Chen
Bo-jiang
BJ
Xu
Lian
L
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000378:metabolism*; D034481:Heterogeneous-Nuclear Ribonucleoprotein Group A-B / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D018960:Hyaluronan Receptors / Q000096:biosynthesis* / Q000235:genetics; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D011379:Prognosis; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics
D034481:Heterogeneous-Nuclear Ribonucleoprotein Group A-B; D018960:Hyaluronan Receptors; D012333:RNA, Messenger; C439768:hnRNP A2