title: Cross-talk between lung and systemic circulation during carbon nanotube respiratory exposure. Potential biomarkers.
abstract: Nanotechnology is an emerging field that demands urgent development of adequate toxicology and risk assessment. The previous experimental data on carbon nanotube respiratory exposure strongly suggest the need for complex evaluation of potential toxicity. Our work demonstrates that after carbon nanotube deposition in the lung, acute local and systemic responses are activated and characterized by a blood gene and protein expression signature. The approach described here will foster the development of biomarkers for application in human screening of nanoparticle exposure.
authors.affiliation: Toxicology and Molecular Biology Branch and Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA.
authors.forename: Aaron
authors.initials: A
authors.lastname: Erdely
authors.forename: Tracy
authors.initials: T
authors.lastname: Hulderman
authors.forename: Rebecca
authors.initials: R
authors.lastname: Salmen
authors.forename: Angie
authors.initials: A
authors.lastname: Liston
authors.forename: Patti C
authors.initials: PC
authors.lastname: Zeidler-Erdely
authors.forename: Diane
authors.initials: D
authors.lastname: Schwegler-Berry
authors.forename: Vincent
authors.initials: V
authors.lastname: Castranova
authors.forename: Shozo
authors.initials: S
authors.lastname: Koyama
authors.forename: Yoong-Ahm
authors.initials: YA
authors.lastname: Kim
authors.forename: Morinobu
authors.initials: M
authors.lastname: Endo
authors.forename: Petia P
authors.initials: PP
authors.lastname: Simeonova
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D015415:Biomarkers; D001798:Blood Proteins / Q000032:analysis*; D004781:Environmental Exposure / Q000032:analysis*; D005240:Feasibility Studies; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D037742:Nanotubes, Carbon / Q000032:analysis* / Q000737:chemistry*; D052638:Particulate Matter / Q000008:administration & dosage* / Q000493:pharmacokinetics*
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D037742:Nanotubes, Carbon; D052638:Particulate Matter