The effect of marine n-3 fatty acids in different doses on plasma concentrations of Lp-PLA2 in healthy adults.
BACKGROUND
Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an emerging independent risk factor for cardiovascular disease (CVD). Lp-PLA(2) can be modified by lipid lowering drugs, but it is unknown whether diet can reduce plasma levels of Lp-PLA(2).


OBJECTIVE
The aim of the trial was to study the effect of marine n-3 polyunsaturated fatty acids (PUFA) on plasma Lp-PLA(2) levels in healthy subjects.


METHODS
Sixty healthy subjects were randomized to a moderate dose (2 g) of n-3 PUFA, a high dose (6.6 g) of n-3 PUFA or olive oil (control) daily for 12 weeks. Plasma Lp-PLA(2) was measured at baseline and after the interventions.


RESULTS
Plasma Lp-PLA(2) levels were unchanged in all three groups before and after the supplements. Neither did the results differ between groups. There was no correlation between the content of n-3 PUFA in platelets or granulocytes or plasma Lp-PLA(2).


CONCLUSIONS
Marine n-3 PUFA had no effect on plasma levels of Lp-PLA(2) in healthy adults and relatively young people.
Pedersen
Maria Weinkouff
MW
Department of Cardiology and Center for Cardiovascular Research, Aalborg Hospital, Arhus University Hospital, Aalborg, Denmark.
Koenig
Wolfgang
W
Christensen
Jeppe Hagstrup
JH
Schmidt
Erik Berg
EB
D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000097:blood*; D000328:Adult; D001792:Blood Platelets / Q000737:chemistry; D015992:Body Mass Index; D002784:Cholesterol; D008078:Cholesterol, LDL / Q000097:blood; D019587:Dietary Supplements; D004281:Docosahexaenoic Acids / Q000097:blood; D015118:Eicosapentaenoic Acid / Q000097:blood; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage*; D006098:Granulocytes / Q000737:chemistry; D006801:Humans; D008297:Male; D008875:Middle Aged; D000069463:Olive Oil; D010938:Plant Oils / Q000008:administration & dosage
D008078:Cholesterol, LDL; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D000069463:Olive Oil; D010938:Plant Oils; D004281:Docosahexaenoic Acids; D002784:Cholesterol; D015118:Eicosapentaenoic Acid; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase