title: An overview of hazard and risk assessment of the OECD high production volume chemical category--long chain alcohols [C(6)-C(22)] (LCOH).
abstract: This review summarizes the findings of the assessment report for the category, long chain alcohols (LCOH) with a carbon chain length range of C(6)-C(22) covering 30 substances, and >1.5million tonnes/year consumed globally. The category was evaluated under the Organization for Economic Co-operation and Development (OECD) high production volume chemicals program in 2006. The main findings of the assessment include: (1) no unacceptable human or environmental risks were identified; (2) these materials are rapidly and readily biodegradable; (3) a parabolic relationship was demonstrated between carbon chain length and acute and chronic aquatic toxicity; (4) category-specific (quantitative) structure-activity relationships were developed enabling prediction of properties across the entire category; (5) LCOH occur naturally in the environment in an equilibrium between synthesis and degradation; (6) industry coming together and sharing resources results in minimizing the need for additional animal tests, produces cost savings, and increases scientific quality of the assessment.
authors.affiliation: The Soap and Detergent Association, Washington, District of Columbia, DC 20005, USA. hasa@dmu.dk
authors.forename: Hans
authors.initials: H
authors.lastname: Sanderson
authors.forename: Scott E
authors.initials: SE
authors.lastname: Belanger
authors.forename: Peter R
authors.initials: PR
authors.lastname: Fisk
authors.forename: Christoph
authors.initials: C
authors.lastname: Schäfers
authors.forename: Gauke
authors.initials: G
authors.lastname: Veenstra
authors.forename: Allen M
authors.initials: AM
authors.lastname: Nielsen
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kasai
authors.forename: Andreas
authors.initials: A
authors.lastname: Willing
authors.forename: Scott D
authors.initials: SD
authors.lastname: Dyer
authors.forename: Kathleen
authors.initials: K
authors.lastname: Stanton
authors.forename: Richard
authors.initials: R
authors.lastname: Sedlak
mesh_terms: D000818:Animals; D001673:Biodegradation, Environmental; D002617:Chemical Industry; D003621:Daphnia; D004784:Environmental Monitoring; D005233:Fatty Alcohols / Q000737:chemistry / Q000633:toxicity*; D006801:Humans; D008322:Mammals; D018570:Risk Assessment; D012995:Solubility; D014835:Volatilization; D014874:Water Pollutants, Chemical / Q000737:chemistry / Q000633:toxicity
chemical_list: D005233:Fatty Alcohols; D014874:Water Pollutants, Chemical