Molecular mechanisms of metastasis in prostate cancer.
Prostate cancer (PCa) preferentially metastasizes to the bone marrow stroma of the axial skeleton. This activity is the principal cause of PCa morbidity and mortality. The exact mechanism of PCa metastasis is currently unknown, although considerable progress has been made in determining the key players in this process. In this review, we present the current understanding of the molecular processes driving PCa metastasis to the bone.
Clarke
Noel W
NW
Genito-Urinary Cancer Research Group, School of Cancer and Imaging Sciences, Paterson Institute for Cancer Research, Christie Hospital, University of Manchester, Manchester, UK.
Hart
Claire A
CA
Brown
Mick D
MD
D001859:Bone Neoplasms / Q000503:physiopathology / Q000556:secondary*; D002448:Cell Adhesion / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D018925:Chemokines / Q000502:physiology; D006801:Humans; D008055:Lipids / Q000502:physiology; D008297:Male; D009362:Neoplasm Metastasis / Q000503:physiopathology; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000503:physiopathology
D018925:Chemokines; D008055:Lipids