Cobb syndrome: a case report and systematic review of the literature.
We report on a case of Cobb syndrome, a rare metameric disorder, characterized by a vascular abnormality of the spinal cord, with an associated vascular skin lesion of the same metamere, in an 8-year-old girl presenting with leg weakness. Magnetic resonance imaging revealed a spinal arteriovenous malformation at the level of T(10)-L(5). This finding, together with a large, pigmented nevus at this level, is diagnostic for Cobb syndrome. A systematic review of the literature on Cobb syndrome, with a focus on treatment and outcomes, is presented. Current treatment options include combinations of embolization, neurosurgical intervention, corticosteroid therapy, and radiotherapy.
Clark
Marissa Tubridy
MT
Department of Paediatrics, Monash Medical Centre, Monash University, Melbourne, Victoria, Australia.
Brooks
Emma L
EL
Chong
Winston
W
Pappas
Chris
C
Fahey
Michael
M
D020785:Central Nervous System Vascular Malformations / Q000150:complications*; D002648:Child; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D012871:Skin Diseases / Q000150:complications*; D013122:Spinal Diseases / Q000150:complications*