Evaluation of antitumor activity of rubomycin deposited in absorbable polymeric microparticles.
An experimental dosage form of rubomycin is developed: the drug is incorporated in absorbable polymeric (polyhydroxybutyrate) matrix in the form of microparticles. Antitumor efficiency of this rubomycin dosage form was studied in laboratory mice with transplanted Ehrlich ascitic carcinoma. Rubomycin deposited in polymeric microparticles exhibited pronounced antitumor activity, inhibited the proliferative activity of Ehrlich ascitic carcinoma, and improved survival of mice with tumors. This dosage form of the drug can be used for local injections.
Shishatskaya
E I
EI
Institute of Biophysics, Siberian Division of Russian Academy of Sciences.
Goreva
A V
AV
Voinova
O N
ON
Inzhevatkin
E V
EV
Khlebopros
R G
RG
Volova
T G
TG
D000042:Absorption; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000401:mortality; D003630:Daunorubicin / Q000008:administration & dosage* / Q000627:therapeutic use*; D006885:Hydroxybutyrates; D051379:Mice; D008807:Mice, Inbred BALB C; D008863:Microspheres; D011091:Polyesters; D000094122:Polyhydroxybutyrates
D000903:Antibiotics, Antineoplastic; D003630:Daunorubicin; D006885:Hydroxybutyrates; D011091:Polyesters; C003182:poly-beta-hydroxybutyrate; D000094122:Polyhydroxybutyrates