title: TRAIL-enhancing activity of Erythrinan alkaloids from Erythrina velutina.
abstract: A new Erythrinan alkaloid (1), erythodine N-oxide, was isolated from the seeds of Erythrina velutina together with seven known Erythrinan alkaloids (2-7, 9) and an indole alkaloid (8). The structure of new compound (1) was elucidated by spectroscopic methods. Six of the nine compounds showed enhanced activity when combined with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Erysotrine (4) did not show cytotoxic activity by itself, but exhibited significant cytotoxicity when combined with TRAIL.
authors.affiliation: Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Kanda, Tokyo, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Ozawa
authors.forename: Tadahiro
authors.initials: T
authors.lastname: Etoh
authors.forename: Masahiko
authors.initials: M
authors.lastname: Hayashi
authors.forename: Kanki
authors.initials: K
authors.lastname: Komiyama
authors.forename: Akio
authors.initials: A
authors.lastname: Kishida
authors.forename: Ayumi
authors.initials: A
authors.lastname: Ohsaki
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D000970:Antineoplastic Agents; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004357:Drug Synergism; D004895:Erythrina / Q000737:chemistry*; D006801:Humans; D026121:Indole Alkaloids; D019169:Jurkat Cells; D015394:Molecular Structure; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D026121:Indole Alkaloids; D053221:TNF-Related Apoptosis-Inducing Ligand