title: Growth of uterine leiomyomata among premenopausal black and white women.
abstract: Uterine leiomyomata (fibroids) are the leading cause of hysterectomy in the United States. Black women have a greater fibroid burden than whites, yet no study has systematically evaluated the growth of fibroids in blacks and whites. We prospectively tracked growth for 262 fibroids (size range: 1-13 cm in diameter) from 72 premenopausal participants (38 blacks and 34 whites). Fibroid volume was measured by computerized analysis of up to four MRI scans over 12 months. We used mixed effects models to identify factors that are associated with growth, and results were converted to percent change per 6 months for clinical relevance. The median growth rate was 9% (range: -89% to +138%). Seven percent of fibroids regressed (>20% shrinkage). Tumors from the same woman grew at different rates (within-woman component of variation was twice the component among women; both were significant, P < 0.001). Black and white women less than 35 years of age had similar fibroid growth rates. However, growth rates declined with age for whites but not for blacks (P = 0.05). The odds of a tumor growing more than 20% in 6 months also decreased with age for whites but not for blacks (P < 0.01). Growth rates were not influenced by tumor size, location, body mass index, or parity. We conclude that (i) spontaneous regression of fibroids occurs; (ii) fibroids from the same woman grow at different rates, despite a uniform hormonal milieu; (iii) fibroid size does not predict growth rate; and (iv) age-related differences in fibroid growth between blacks and whites may contribute to the higher symptom burden for black women.
authors.affiliation: Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
authors.forename: Shyamal D
authors.initials: SD
authors.lastname: Peddada
authors.forename: Shannon K
authors.initials: SK
authors.lastname: Laughlin
authors.forename: Kelly
authors.initials: K
authors.lastname: Miner
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Guyon
authors.forename: Karen
authors.initials: K
authors.lastname: Haneke
authors.forename: Heather L
authors.initials: HL
authors.lastname: Vahdat
authors.forename: Richard C
authors.initials: RC
authors.lastname: Semelka
authors.forename: Ania
authors.initials: A
authors.lastname: Kowalik
authors.forename: Diane
authors.initials: D
authors.lastname: Armao
authors.forename: Barbara
authors.initials: B
authors.lastname: Davis
authors.forename: Donna Day
authors.initials: DD
authors.lastname: Baird
mesh_terms: D000328:Adult; D001741:Black or African American; D005260:Female; D006801:Humans; D015994:Incidence; D007889:Leiomyoma / Q000453:epidemiology / Q000208:ethnology* / Q000473:pathology*; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D017697:Premenopause; D014481:United States / Q000453:epidemiology; D014594:Uterine Neoplasms / Q000453:epidemiology / Q000208:ethnology* / Q000473:pathology*; D044465:White People; D055815:Young Adult