title: Sertoli-Leydig cell tumor of the testis in a Sprague-Dawley rat.
abstract: A rare intratubular gonadal stromal tumor was present in the testis of a 7-wk-old male Sprague-Dawley rat. The tumor comprised an intratubular mixture of 2 types of tumor cells with intercellular junctions: the predominant tumor cells were consistent with a Sertoli cell origin, and cells comprising the minor population were situated on basolateral side of the tubuli, consistent with a Leydig cell origin. The neoplastic Sertoli cells had large pleomorphic nuclei and clear cytoplasm with many tubulovesicular cristae and free ribosomes, whereas the neoplastic Leydig cells showed relatively small pleomorphic nuclei, dark cytoplasm with rich smooth endoplasmic reticulum, numerous mitochondria, and lipid droplets. Occasionally, a few transitional type neoplastic cells were observed. The presence of a thick or multilayered basement membrane was confirmed except in tumor-infiltrative lesions. The present case was considered to be a testicular mixed tubular Sertoli-Leydig cell tumor in a Sprague-Dawley rat.
authors.affiliation: Toxicologic Pathology, Azabu University School of Veterinary Medicine, Kanagawa, Japan. wakui@azabu-u.ac.jp
authors.forename: Shin
authors.initials: S
authors.lastname: Wakui
authors.forename: Tomoko
authors.initials: T
authors.lastname: Muto
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Kenta
authors.initials: K
authors.lastname: Ishida
authors.forename: Masataka
authors.initials: M
authors.lastname: Nakano
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takahashi
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Masakuni
authors.initials: M
authors.lastname: Furusato
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hano
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron / Q000662:veterinary; D051381:Rats; D017207:Rats, Sprague-Dawley; D012376:Rodent Diseases / Q000473:pathology*; D018310:Sertoli-Leydig Cell Tumor / Q000473:pathology / Q000662:veterinary*; D013736:Testicular Neoplasms / Q000473:pathology / Q000662:veterinary*