In situ "click" assembly of small molecule matrix metalloprotease inhibitors containing zinc-chelating groups.
A panel of small molecule-based MMP inhibitors containing rhodanine warheads was assembled using "one-pot" click chemistry. Upon biological screening, moderate inhibitors were identified which specifically targets MMP-7 and MMP-13 over other MMPs.
Hu
Mingyu
M
Department of Chemistry, NUS MedChem Program of the Office of Life Sciences, National University of Singapore, Singapore 117543.
Li
Junqi
J
Yao
Shao Q
SQ
D002614:Chelating Agents / Q000737:chemistry*; D061965:Matrix Metalloproteinase Inhibitors; D008958:Models, Molecular; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D012236:Rhodanine / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
D002614:Chelating Agents; D061965:Matrix Metalloproteinase Inhibitors; D011480:Protease Inhibitors; D012236:Rhodanine; D015032:Zinc