title: Growth factor delivery approaches in hydrogels.
abstract: The controlled delivery of growth factors is a very challenging task because many different issues have to be addressed to develop the best suited system. A wide range of approaches have been employed for the controlled delivery of growth factors by hydrogels. Direct loading, electrostatic interaction, covalent binding, and the use of carriers are the main strategies presented in the literature. They are all detailed in the first part of this review. Recent work emphasizing biologically inspired strategies is also included. Also, both natural and synthetic materials are discussed. The second part comprises the methods to evaluate such delivery approaches. Both in vivo and in vitro techniques are presented. Improvements based on the discussed approaches may illustrate future paths toward the development of an ideal growth factor delivery system.
authors.affiliation: Université d'Evry Val d'Essonne, Ecole doctorale des Génomes Aux Organismes, Boulevard François Mitterrand 91025 Evry, cedex France.
authors.forename: Amanda K Andriola
authors.initials: AK
authors.lastname: Silva
authors.forename: Cyrille
authors.initials: C
authors.lastname: Richard
authors.forename: Michel
authors.initials: M
authors.lastname: Bessodes
authors.forename: Daniel
authors.initials: D
authors.lastname: Scherman
authors.forename: Otto-Wilhelm
authors.initials: OW
authors.lastname: Merten
mesh_terms: D001672:Biocompatible Materials; D016503:Drug Delivery Systems; D020100:Hydrogels; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage*
chemical_list: D001672:Biocompatible Materials; D020100:Hydrogels; D036341:Intercellular Signaling Peptides and Proteins