Human chorionic gonadotropin-secreting clear cell renal cell carcinoma with paraneoplastic gynaecomastia.
A 60-year-man presented with painful gynaecomastia and polycythaemia due to a beta-human chorionic gonadotropin (HCG)-secreting clear cell renal cell carcinoma. A computed tomographic scan of his chest, abdomen and pelvis showed an enhancing 9x9 cm mass in the right kidney suggestive of a renal cell carcinoma. He underwent right radical nephrectomy and the histology showed a clear cell renal cell carcinoma. Following his nephrectomy, over the next 6 months, his gynaecomastia regressed and serum beta-HCG levels became undetectable. Nine months after his nephrectomy, he developed a paratesticular lesion involving scrotal skin, for which he underwent a right radical orchidectomy. Histopathology of the paratesticular lesion showed metastatic renal cell carcinoma.
Mohammed Ilyas
Mohammed Iyoob
MI
Department of Urology, Churchill Hospital, Oxford Radcliffe Hospitals Trust, Oxford, UK. driyoob@yahoo.com
Turner
Gareth D H
GD
Cranston
David
D
D014408:Biomarkers, Tumor / Q000097:blood / Q000378:metabolism*; D002292:Carcinoma, Renal Cell / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D006063:Chorionic Gonadotropin / Q000097:blood / Q000378:metabolism*; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006177:Gynecomastia / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D007680:Kidney Neoplasms / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D014057:Tomography, X-Ray Computed
D014408:Biomarkers, Tumor; D006063:Chorionic Gonadotropin