Major improvement of percutaneous cardiovascular procedure outcomes with radial artery catheterisation: results from the PREVAIL study.
OBJECTIVE
To obtain a "snapshot" view of access-specific percutaneous cardiovascular procedures outcomes in the real world.


METHODS
Multicentre, prospective study performed over a 30-day period.


METHODS
Nine hospitals with invasive cardiology facilities, reflecting the contemporary state of healthcare.


METHODS
Unselected consecutive sample of patients undergoing any percutaneous cardiovascular procedure requiring an arterial access.


METHODS
Percutaneous cardiovascular procedures by radial or femoral access


METHODS
The primary outcome was the combined incidence of in-hospital (a) major and minor haemorrhages; (b) peri-procedural stroke; and (c) entry-site vascular complications. The secondary outcome was the combined incidence of in-hospital death and myocardial infarction/reinfarction. For analysis purposes, outcomes were allocated to arterial access-determined study arms on an intention-to treat basis. Multivariable analysis adjusted using propensity score was performed to correct for selection bias related to arterial site.


RESULTS
A total of 1052 patients were enrolled: 509 underwent radial access and 543 femoral access. In both groups, 40% underwent a coronary angioplasty. Relative to femoral access, radial access was associated with a lower incidence both of primary (4.2% vs 1.96%, p = 0.03, respectively) and secondary endpoints (3.1% vs 0.6%, p = 0.005, respectively). Multivariate analysis, adjusted for procedural and clinical confounders, confirmed that intention-to-access via the radial route was significantly and independently associated with a decreased risk both of primary (OR 0.37, 95% CI 0.16 to 0.84) and secondary endpoints (OR 0.14, 95% CI 0.03 to 0.62).


CONCLUSIONS
Our study indicates strikingly better outcomes of percutaneous cardiovascular procedures with radial access versus femoral access in contemporary, real-world clinical settings.
Pristipino
C
C
San Filippo Neri Hospital, Rome, Italy. pristipino.c@libero.it
Trani
C
C
Nazzaro
M S
MS
Berni
A
A
Patti
G
G
Patrizi
R
R
Pironi
B
B
Mazzarotto
P
P
Gioffrè
G
G
Biondi-Zoccai
G G L
GG
Richichi
G
G
D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects* / Q000379:methods; D006328:Cardiac Catheterization / Q000009:adverse effects* / Q000379:methods; D005260:Female; D005263:Femoral Artery; D006470:Hemorrhage / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology; D017202:Myocardial Ischemia / Q000628:therapy*; D011446:Prospective Studies; D017534:Radial Artery; D016896:Treatment Outcome