Pharmacokinetics and bioequivalence evaluation of two fixed-dose tablet formulations of dihydroartemisinin and piperaquine in Vietnamese subjects.
The two fixed-dose combinations of dihydroartemisinin and piperaquine (Artekin and Arterakine) were found to be bioinequivalent in healthy Vietnamese subjects. However, because the peak plasma concentrations and areas under the concentration-time curves of dihydroartemisinin and piperaquine were only marginally different between the two formulations, similar therapeutic efficacies are expected in the treatment of malaria infections.
Chinh
Nguyen Trong
NT
Department of Infectious Diseases, Military Hospital, Hanoi, Vietnam.
Quang
Nguyen Ngoc
NN
Thanh
Nguyen Xuan
NX
Dai
Bui
B
Geue
Jason P
JP
Addison
Russell S
RS
Travers
Thomas
T
Edstein
Michael D
MD
D000328:Adult; D000962:Antimalarials / Q000032:analysis / Q000493:pharmacokinetics*; D019540:Area Under Curve; D037621:Artemisinins / Q000032:analysis / Q000493:pharmacokinetics*; D002626:Chemistry, Pharmaceutical; D002853:Chromatography, Liquid; D018592:Cross-Over Studies; D004338:Drug Combinations; D006207:Half-Life; D006801:Humans; D008297:Male; D011804:Quinolines / Q000032:analysis / Q000493:pharmacokinetics*; D053719:Tandem Mass Spectrometry; D013810:Therapeutic Equivalency; D010879:Piperazines
D000962:Antimalarials; D037621:Artemisinins; D004338:Drug Combinations; D011804:Quinolines; C039060:artenimol; C034759:piperaquine; D010879:Piperazines