title: Postural orthostatic tachycardia in a teenager with Klinefelter syndrome.
abstract: To our knowledge this is the first reported case of postural orthostatic tachycardia syndrome (POTS) in a patient with Klinefelter syndrome. We describe a classic clinical presentation of POTS in an adolescent male with Klinefelter syndrome. Although the etiology of POTS appears to be multifactorial, there is a strong female predominance that suggests a genetic basis. Our patient with Klinefelter syndrome may further support a link with POTS to the X chromosome.
authors.affiliation: University of Arizona College of Medicine, Department of Pediatrics, Tucson, AZ, USA. hainstoc@ohsu.edu
authors.forename: Michael R
authors.initials: MR
authors.lastname: Hainstock
authors.forename: Nancy E
authors.initials: NE
authors.lastname: Gruchala
authors.forename: Nadia
authors.initials: N
authors.lastname: Fike
authors.forename: Ricardo A
authors.initials: RA
authors.lastname: Samson
authors.forename: Scott E
authors.initials: SE
authors.lastname: Klewer
authors.forename: Brent J
authors.initials: BJ
authors.lastname: Barber
mesh_terms: D000293:Adolescent; D041321:Chromosomes, Human, X; D004562:Electrocardiography; D005438:Fludrocortisone / Q000627:therapeutic use; D005440:Fluid Therapy; D006801:Humans; D007713:Klinefelter Syndrome / Q000150:complications* / Q000235:genetics / Q000628:therapy; D008297:Male; D054972:Postural Orthostatic Tachycardia Syndrome / Q000209:etiology* / Q000235:genetics / Q000628:therapy; D012737:Sex Factors
chemical_list: D005438:Fludrocortisone