Physiology of skin aging.
Skin is the most voluminous organ of the body. It assumes several important physiological functions and represents also a "social interface" between an individual and other members of society. This is the main reason its age-dependent modifications are in the forefront of dermatological research and of the "anti-aging" cosmetic industry. Here we concentrate on some aspects only of skin aging, as far as the cellular and extracellular matrix components of skin are concerned. Most well studied mechanisms of skin aging can be situated at the postgenetic level, both epigenetic and post-translational mechanisms being involved. Some of these mechanisms will be reviewed as well as the capacity of fucose- and rhamnose-rich oligo- and polysaccharides (FROP and RROP) to counteract several of the mechanisms involved in skin aging.
Robert
L
L
Laboratoire de recherche ophtalmologique, université Paris-5, Hôtel-Dieu, 1, place du Parvis-Notre-Dame, 75181 Paris cedex 04, France. lrobert5@wanadoo.fr
Labat-Robert
J
J
Robert
A-M
AM
D000818:Animals; D001284:Atrophy; D005109:Extracellular Matrix / Q000502:physiology; D005347:Fibroblasts / Q000166:cytology; D005609:Free Radicals; D005643:Fucose / Q000494:pharmacology; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006801:Humans; D015603:Keratinocytes / Q000166:cytology; D034904:Lamin Type A; D015416:Maillard Reaction / Q000187:drug effects; D051379:Mice; D009687:Nuclear Proteins / Q000378:metabolism; D009844:Oligosaccharides / Q000494:pharmacology / Q000627:therapeutic use; D010196:Pancreatic Elastase / Q000502:physiology; D010455:Peptides / Q000378:metabolism; D011498:Protein Precursors / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D012210:Rhamnose / Q000494:pharmacology; D015595:Skin Aging / Q000187:drug effects / Q000473:pathology / Q000502:physiology* / Q000528:radiation effects; D013472:Sunlight / Q000009:adverse effects
D005609:Free Radicals; D017127:Glycation End Products, Advanced; D034904:Lamin Type A; D009687:Nuclear Proteins; D009844:Oligosaccharides; D010455:Peptides; D011498:Protein Precursors; D011956:Receptors, Cell Surface; C090764:prelamin A; D005643:Fucose; D010196:Pancreatic Elastase; D012210:Rhamnose