Prognostic value of CXCR4 and FAK expression in acute myelogenous leukemia.
We analysed, by flow cytometry, the "adhesive" phenotype of acute myelogenous leukemia (AML) cells from 36 patients treated in our institution. In univariate analysis, the main prognostic factor for CR achievement was lower CXCR4 expression (p=0.03). Overall survival (OS) was negatively influenced by higher CXC chemokine receptor 4 (CXCR4) (p=0.01), very late antigen-4 (VLA-4) (p=0.01), and focal adhesion kinase (FAK) expression (p=0.04). Combination of these markers allowed to distinguish two prognostic groups: patients overexpressing 2 or 3 factors had a significantly shorter OS (p=0.015). CXCR4, VLA-4 and FAK are new phenotypic markers which could be helpful to establish risk-stratified therapeutic strategies.
Tavernier-Tardy
Emmanuelle
E
Département d'Hématologie, Institut de Cancérologie de la Loire, Saint Etienne, France. emmanuelle.tavernier@mageos.com
Cornillon
Jérôme
J
Campos
Lydia
L
Flandrin
Pascale
P
Duval
Amélie
A
Nadal
Nathalie
N
Guyotat
Denis
D
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015815:Cell Adhesion Molecules / Q000235:genetics; D005260:Female; D005434:Flow Cytometry; D051416:Focal Adhesion Protein-Tyrosine Kinases / Q000235:genetics*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011379:Prognosis; D019718:Receptors, CXCR4 / Q000235:genetics*
C527276:CXCR4 protein, human; D015815:Cell Adhesion Molecules; D019718:Receptors, CXCR4; D051416:Focal Adhesion Protein-Tyrosine Kinases