Poly(n-butyl cyanoacrylate) nanoparticles via miniemulsion polymerization. 2. PEG-based surfactants.
This study aimed at synthesizing PEG-coated poly(n-butyl cyanoacrylate) nanoparticles by miniemulsion polymerization. Despite the high reactivity of butyl cyanoacrylate, nanoparticles were successfully obtained by miniemulsion polymerization of butyl cyanoacrylate-in-water emulsions stabilized by three PEG-based surfactants: Brij78, Brij700, and Tween80. Their physico-chemical properties were thoroughly investigated as a function of surfactant structure and concentration and discussed on the basis of results obtained from interfacial tension measurements (dodecane-water). Results clearly showed the influence of the length of the PEG part of the surfactant on the final properties of the particles.
Wu
M
M
Laboratoire de Chimie Physique Macromoléculaire, Nancy-Université, CNRS, 1 rue Grandville, B.P. 20451, F-54001 Nancy, France.
Dellacherie
E
E
Durand
A
A
Marie
E
E
D000327:Adsorption; D003911:Dextrans / Q000737:chemistry*; D004655:Emulsions / Q000737:chemistry*; D004659:Enbucrilate / Q000737:chemistry*; D008968:Molecular Conformation; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry*; D013499:Surface Properties; D013500:Surface Tension; D013501:Surface-Active Agents / Q000737:chemistry*
D003911:Dextrans; D004655:Emulsions; D013501:Surface-Active Agents; D011092:Polyethylene Glycols; D004659:Enbucrilate