Effect of tetrapeptides Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly on the structure and function of the thyroid gland in neonatally hypophysectomized chickens.
Tetrapeptides Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly were synthesized on the basis of amino acid composition of pituitary cytomedins. Administration of these tetrapeptides to hypophysectomized chickens for 40 days was followed by an increase in the concentrations of thyrotropic hormone and thyroid hormones and recovery of thyroid gland structure.
Kuznik
B I
BI
Department of Normal Physiology, Department of Histology, Chita State Medical Academy. bi_kuznik@mail.ru
Pateyuk
A V
AV
Rusaeva
N S
NS
D000595:Amino Acid Sequence; D000818:Animals; D002645:Chickens; D007016:Hypophysectomy; D009842:Oligopeptides / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology*; D013961:Thyroid Gland / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism; D013963:Thyroid Hormones / Q000097:blood; D013972:Thyrotropin / Q000097:blood
D009842:Oligopeptides; D013963:Thyroid Hormones; D013972:Thyrotropin; C421253:alanyl-glutamyl-aspartyl-glycine