title: Low frequency stimulation of the pedunculopontine nucleus modulates electrical activity of subthalamic neurons in the rat.
abstract: Electrical stimulation of the rat pedunculopontine nucleus (PPTg) (<25 Hz) synchronized firing of subthalamic neurons (STN) with each stimulus, and a continuous irregular activity often preceded recovery of burst discharges in control as well as in 6-hydroxydopamine lesioned animals. Firing was blocked both by increasing frequency of stimulation (>50 Hz) and current intensity (>500 microA). The data suggest that clinically relevant frequencies for PPTg deep brain stimulation in Parkinson's disease modulate burst discharges in STN neurons.
authors.affiliation: Department of Biomedical Sciences and Technologies, University of L'Aquila, L'Aquila, Italy.
authors.forename: Annamaria
authors.initials: A
authors.lastname: Capozzo
authors.forename: Tiziana
authors.initials: T
authors.lastname: Florio
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Confalone
authors.forename: Daniela
authors.initials: D
authors.lastname: Minchella
authors.forename: Paolo
authors.initials: P
authors.lastname: Mazzone
authors.forename: Eugenio
authors.initials: E
authors.lastname: Scarnati
mesh_terms: D000200:Action Potentials / Q000502:physiology; D018663:Adrenergic Agents / Q000633:toxicity; D000344:Afferent Pathways / Q000293:injuries / Q000502:physiology; D000704:Analysis of Variance; D000818:Animals; D001703:Biophysics / Q000379:methods; D004558:Electric Stimulation / Q000379:methods*; D008297:Male; D009474:Neurons / Q000502:physiology*; D016627:Oxidopamine / Q000633:toxicity; D045042:Pedunculopontine Tegmental Nucleus / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020531:Subthalamic Nucleus / Q000166:cytology*
chemical_list: D018663:Adrenergic Agents; D016627:Oxidopamine