The impact of immune gene polymorphisms in kidney and liver transplantation.
Since the completion of the Human Genome Project, it has become clear that genetic variation exists among individuals that can affect functional gene expression. This finding raises the possibility that differences in genetic phenotypes may account for the interindividual responses seen in the context of the alloimmune response. This review highlights studies examining the relative role of immunologic gene polymorphism in the context of renal and liver transplant outcomes (eg, acute rejection and graft survival). Furthermore, it examines the limitations and pitfalls in the study designs and concludes with the potential of single nucleotide polymorphism analysis in the future care of transplant recipients.
Nickerson
Peter
P
Department of Medicine, University of Manitoba, 820 Sherbrook Street Winnipeg, Manitoba, Canada. peter.nickerson@bloodservices.ca
D018122:B7-1 Antigen / Q000235:genetics / Q000276:immunology; D051940:B7-2 Antigen / Q000235:genetics / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000276:immunology; D018925:Chemokines / Q000235:genetics / Q000276:immunology; D016207:Cytokines / Q000235:genetics / Q000276:immunology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000276:immunology; D016030:Kidney Transplantation / Q000276:immunology*; D016031:Liver Transplantation / Q000276:immunology*; D020641:Polymorphism, Single Nucleotide
D018122:B7-1 Antigen; D051940:B7-2 Antigen; D015815:Cell Adhesion Molecules; D018925:Chemokines; D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins