title: Oxidation of antiparasitic 2-substituted quinolines using metalloporphyrin catalysts: scale-up of a biomimetic reaction for metabolite production of drug candidates.
abstract: A study comparing the chemical oxidation of drug candidates with cell-based metabolism (liver microsomes, hepatocytes) shows that biomimetic oxidation can replace the biological approach, thus allowing access to large quantities of metabolites, which can also be used for the preparation of new products.
authors.affiliation: Alpha-Chimica, 5 rue Jean-Baptiste Clément, F-92296 Châtenay-Malabry, France.
authors.forename: Bernardin
authors.initials: B
authors.lastname: Akagah
authors.forename: Anh Tuan
authors.initials: AT
authors.lastname: Lormier
authors.forename: Alain
authors.initials: A
authors.lastname: Fournet
authors.forename: Bruno
authors.initials: B
authors.lastname: Figadère
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000737:chemistry* / Q000378:metabolism; D040761:Biomimetic Materials / Q000737:chemistry* / Q000378:metabolism; D002384:Catalysis; D055808:Drug Discovery; D006801:Humans; D008665:Metalloporphyrins / Q000737:chemistry* / Q000378:metabolism; D010084:Oxidation-Reduction; D011804:Quinolines / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000977:Antiparasitic Agents; D008665:Metalloporphyrins; D011804:Quinolines; C037219:quinoline