Hydronaphthalenones and a dihydroramulosin from the endophytic fungus PSU-N24.
Three new hydronaphthalenone derivatives (1-3) and one new dihydroramulosin derivative (4), were isolated from the endophytic fungus PSU-N24 together with eight known compounds. Their structures were elucidated by spectroscopic methods. Griseofulvin (9) displayed strong antifungal activity against Microsporum gypseum SH-MU-4 with a minimum inhibitory concentration (MIC) value of 2 microg/ml while all metabolites exhibited very weak antibacterial activity (MIC value>or=128 microg/ml) against Staphylococcus aureus, both standard and methicillin-resistant strains. 3-(2-Hydroxypropyl)benzene-1,2-diol (10) showed moderate antimalarial activity against Plasmodiun falciparum with an IC(50) value of 6.68 microg/ml. For antimycobacterial activity against Mycobacterium tuberculosis, compound 3 gave the best activity with the MIC value of 12.50 microg/ml.
Sommart
Ubonta
U
Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Songkla, Thailand.
Rukachaisirikul
Vatcharin
V
Sukpondma
Yaowapa
Y
Phongpaichit
Souwalak
S
Sakayaroj
Jariya
J
Kirtikara
Kanyawim
K
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000962:Antimalarials / Q000138:chemical synthesis / Q000494:pharmacology; D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001578:Benzopyrans / Q000737:chemistry* / Q000302:isolation & purification; D005285:Fermentation; D005658:Fungi / Q000737:chemistry* / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
C115559:8-dihydroramulosin; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000962:Antimalarials; D000995:Antitubercular Agents; D001578:Benzopyrans