Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin.
NKp46+CD3- natural killer lymphocytes isolated from blood, lymphoid organs, lung, liver and uterus can produce granule-dependent cytotoxicity and interferon-gamma. Here we identify in dermis, gut lamina propria and cryptopatches distinct populations of NKp46+CD3- cells with a diminished capacity to degranulate and produce interferon-gamma. In the gut, expression of the transcription factor RORgammat, which is involved in the development of lymphoid tissue-inducer cells, defined a previously unknown subset of NKp46+CD3- lymphocytes. Unlike RORgammat- lamina propria and dermis natural killer cells, gut RORgammat+NKp46+ cells produced interleukin 22. Our data show that lymphoid tissue-inducer cells and natural killer cells shared unanticipated similarities and emphasize the heterogeneity of NKp46+CD3- cells in innate immunity, lymphoid organization and local tissue repair.
Luci
Carmelo
C
Centre d'Immunologie de Marseille-Luminy, Université de la Méditerranée, Institut National de la Santé et de la Recherche Médicale, U631, 13288 Marseille, France.
Reynders
Ana
A
Ivanov
Ivaylo I
II
Cognet
Celine
C
Chiche
Laurent
L
Chasson
Lionel
L
Hardwigsen
Jean
J
Anguiano
Esperanza
E
Banchereau
Jacques
J
Chaussabel
Damien
D
Dalod
Marc
M
Littman
Dan R
DR
Vivier
Eric
E
Tomasello
Elena
E
D000818:Animals; D017252:CD3 Complex / Q000378:metabolism; D002455:Cell Division; D020405:Dermis / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis; D007378:Interleukins / Q000096:biosynthesis; D007413:Intestinal Mucosa / Q000276:immunology*; D008213:Lymphocyte Activation / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D055627:Natural Cytotoxicity Triggering Receptor 1 / Q000276:immunology; D055611:Natural Killer T-Cells / Q000276:immunology*; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D010581:Peyer's Patches / Q000276:immunology; D018168:Receptors, Retinoic Acid / Q000235:genetics / Q000502:physiology*; D011988:Receptors, Thyroid Hormone / Q000235:genetics / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*; D000097043:Interleukin-22
D017252:CD3 Complex; D007371:Interferon-gamma; D007378:Interleukins; D055627:Natural Cytotoxicity Triggering Receptor 1; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D018168:Receptors, Retinoic Acid; D011988:Receptors, Thyroid Hormone; D014157:Transcription Factors; D000097043:Interleukin-22; C112260:NCR1 protein, human; C539900:RORC protein, human; C539901:Rorc protein, mouse