Low-grade endometrial stromal sarcoma of the uterus: review of 10 cases.
BACKGROUND
Low-grade endometrial sarcoma is a rare gynecological tumor (0.2% of female genital tract tumors) mainly observed in women before their 50's.


METHODS
The authors present a series of 10 patients followed in two institutions and describe the treatment administered (cytoreductive surgery, i.e. bilateral annexectomy and total hysterectomy, and medical treatments) and the follow-up.


CONCLUSIONS
Local recurrence occurred in 70% of cases, whereas metastasis was rare even after suboptimal surgical removal of the tumor. Adjuvant progestin therapy is currently the most effective treatment for curing and preventing local recurrence. The use of aromatase inhibitors is a promising research approach.
Landréat
Vincent
V
Department of Obstetric Gynaecology, University Hospital, F-35203 Rennes Cedex 2, France.
Paillocher
Nicolas
N
Catala
Laurent
L
Foucher
Fabrice
F
Descamps
Philippe
P
Levêque
Jean
J
D000328:Adult; D000368:Aged; D016889:Endometrial Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D018203:Sarcoma, Endometrial Stromal / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*