title: Testicular cancer in Luxembourg: incidence and outcome in relation to the different histo-pathological types (1980-2004).
abstract: BACKGROUND
  Increasing incidence rates of testicular cancer have been reported worldwide over the last three decades. Trends over time in the incidence rates of germ cell tumours (GCTs) in Luxembourg (Western Europe) and the outcome, both in relation to the different histological types, were analysed.
  
  
  METHODS
  The population-based files of the Morphologic Tumour Registry collecting at a nation-wide level all testicular cancers diagnosed between 1980 and 2004 in the central department of pathology in Luxembourg were retrospectively reviewed. In addition, the presence of concomitant malignant diseases was investigated.
  
  
  RESULTS
  397 patients with GCT were evaluated. The mean age was 33.7 years (range: 1-72). Most of the patients (58.7%) were between 15 and 34 years of age. The age-standardized incidence rates rose from 4.5 per 10(5) (1980-1984) to 7.7 per 10(5) (2000-2004). Out of 275 (69.3%) pure GCTs, 218 seminomas, 48 embryonal carcinomas, 4 yolk sac tumours, 4 malignant teratomas and 1 choriocarcinoma were identified. 30.7% GCTs were of mixed type with 17 different histological variants. 5.8% of the patients had metachronous concomitant cancers, 2% bilateral GCTs and 3.8% non-testicular neoplasms. In all histological categories, with the exception of the pure seminomas, prognosis was determined within the 24 months following diagnosis; pure seminomas need long time follow-up. Ten-year observed survival rates exceeded mostly 90%. Pure embryonal carcinomas had the worst prognosis with a 10-year observed survival rate of 87.1 +/- 12%.
  
  
  CONCLUSIONS
  Testicular germ cell tumours are rare, highly curable neoplasms that generally occur in young patients. In all histological categories, except for pure seminomas, prognosis was determined within the 24 months after diagnosis. Despite better observed survival rates, patients with pure seminomas, without or with metachronous concomitant non-testicular malignancies, need long time followup strategy.
authors.affiliation: Division of Anatomic Pathology, National Health Laboratory, Luxembourg.
authors.forename: René
authors.initials: R
authors.lastname: Scheiden
authors.forename: Tom
authors.initials: T
authors.lastname: Hein
authors.forename: Catherine
authors.initials: C
authors.lastname: Wagener
authors.forename: Nelly
authors.initials: N
authors.lastname: Kieffer
authors.forename: Stanislas
authors.initials: S
authors.lastname: Lamy
authors.forename: Catherine
authors.initials: C
authors.lastname: Capesius
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D006801:Humans; D015994:Incidence; D007223:Infant; D008189:Luxembourg / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012042:Registries; D015996:Survival Rate; D017741:Survivors; D013736:Testicular Neoplasms / Q000145:classification / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology*; D016896:Treatment Outcome; D055815:Young Adult