Antiplasmodial benzophenones from the trunk latex of Moronobea coccinea (Clusiaceae).
In an effort to find antimalarial drugs, a systematic in vitro evaluation on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) was undertaken on sixty plant extracts collected in French Guiana. The methanol extract obtained from the latex of Moronobea coccinea exhibited a strong antiplasmodial activity (95% at 10microg/ml). The phytochemical investigation of this extract led to the isolation of eleven polycyclic polyprenylated acylphloroglucinols (PPAPs), from which eight showed potent antiplasmodial activity with IC50 ranged from 3.3microM to 37.2microM.
Marti
Guillaume
G
Institut de Chimie des Substances Naturelles, 1, avenue de la Terrasse, CNRS, 91198 Gif-sur-Yvette, France.
Eparvier
Véronique
V
Moretti
Christian
C
Susplugas
Sophie
S
Prado
Soizic
S
Grellier
Philippe
P
Retailleau
Pascal
P
Guéritte
Françoise
F
Litaudon
Marc
M
D000818:Animals; D001577:Benzophenones / Q000737:chemistry* / Q000494:pharmacology*; D028084:Clusiaceae / Q000737:chemistry*; D007840:Latex / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*; D013329:Structure-Activity Relationship
D001577:Benzophenones; D007840:Latex