title: Predictors of vacuum-assisted closure failure of sternotomy wounds.
abstract: OBJECTIVE
  Vacuum-assisted closure (VAC) is a minimally invasive alternative to a muscle flap for closure of sternotomy wounds. The purpose of this study is to evaluate clinical predictors of VAC therapy failure in order to predict which patients would benefit from this approach.
  
  
  METHODS
  A retrospective cohort study of all patients with VAC management of sternotomy wounds between January 1997 and July 2003 was conducted. In this study, 37 patients had VAC management of their wounds post-cardiac surgery. Prior to data collection, 12 risk factors for impaired wound healing were identified. Information was obtained from patient charts and laboratory values.
  
  
  RESULTS
  Eight of the 36 patients failed the VAC therapy. Of the 12 variables studied, three were found to be predictive of VAC outcome. Bacteraemic patients had a higher failure rate as compared to patients with negative blood cultures (p<or=0.01). Patients with wound depth >or=4 cm also had a greater occurrence of VAC failure (p<or=0.01). Finally, VAC failure was significantly higher in patients who had a high degree of bony exposure and sternal instability (BESI, p</=0.03). Patient characteristics and co-morbidities traditionally associated with impaired wound healing did not appear to worsen outcome with VAC.
  
  
  CONCLUSIONS
  Patients who have positive blood cultures, wound depth >or=4 cm or a high degree of BESI tend to have worse outcomes with VAC and may be better managed by a surgical approach. Otherwise, VAC may be a reasonable option even in patients with high risks of impaired wound healing. Prospective randomised studies are needed to validate these hypotheses.
authors.affiliation: Department of Plastic and Reconstructive Surgery, University of Montreal, Montreal, QC, Canada. perritwin@hotmail.com
authors.forename: Perry
authors.initials: P
authors.lastname: Gdalevitch
authors.forename: Jonathan
authors.initials: J
authors.lastname: Afilalo
authors.forename: Chen
authors.initials: C
authors.lastname: Lee
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006348:Cardiac Surgical Procedures; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D054843:Negative-Pressure Wound Therapy; D011183:Postoperative Complications / Q000601:surgery*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D013249:Sternum / Q000601:surgery*; D013530:Surgical Wound Infection / Q000601:surgery; D017211:Treatment Failure; D014945:Wound Healing