title: CAD/CAM and rapid prototyped scaffold construction for bone regenerative medicine and surgical transfer of virtual planning: a pilot study.
abstract: We developed a model to test new bone constructs to replace spare skeletal segments originating from new generation scaffolds for bone marrow-derived mesenchymal stem cells. Using computed tomography (CT) data, scaffolds were defined using computer-aided design/computer-aided manufacturing (CAD/CAM) for rapid prototyping by three-dimensional (3D) printing. A bone defect was created in pig mandible ramus by condyle resection for CT and CAD/CAM elaboration of bone volume for cutting and scaffold restoration. The protocol produced a perfect-fitting bone substitute model for rapid prototyped hydroxyapatite (HA) scaffolds. A surgical guide system was developed to accurately reproduce virtually planned bone sectioning procedures in animal models to obtain a perfect fit during surgery.
authors.affiliation: Maxillo-Facial Prosthodontics, Section of Prosthodontics, Department of Oral Science, Alma Mater Studiorum University of Bologna, Bologna, Italy. leonardo.ciocca@unibo.it
authors.forename: L
authors.initials: L
authors.lastname: Ciocca
authors.forename: F
authors.initials: F
authors.lastname: De Crescenzio
authors.forename: M
authors.initials: M
authors.lastname: Fantini
authors.forename: R
authors.initials: R
authors.lastname: Scotti
mesh_terms: D000818:Animals; D018786:Bone Substitutes / Q000378:metabolism / Q000627:therapeutic use; D016025:Bone Transplantation / Q000379:methods; D017076:Computer-Aided Design; D003758:Dental Implantation, Endosseous / Q000379:methods*; D017267:Dental Prosthesis Design / Q000379:methods*; D017886:Durapatite / Q000627:therapeutic use; D008335:Mandibular Condyle / Q000601:surgery*; D059630:Mesenchymal Stem Cells / Q000166:cytology; D008953:Models, Anatomic; D010027:Osteotomy / Q000379:methods; D010865:Pilot Projects; D019651:Plastic Surgery Procedures / Q000379:methods; D044968:Regenerative Medicine / Q000295:instrumentation / Q000379:methods; D025321:Surgery, Computer-Assisted / Q000379:methods; D013552:Swine; D023822:Tissue Engineering / Q000295:instrumentation / Q000379:methods; D054457:Tissue Scaffolds; D014057:Tomography, X-Ray Computed
chemical_list: D018786:Bone Substitutes; D017886:Durapatite