Palladium-catalyzed coupling of hydroxylamines with aryl bromides, chlorides, and iodides.
The bis-pyrazole phosphine ligand BippyPhos is effective for the palladium-catalyzed cross-coupling of hydroxylamines with aryl bromides, chlorides, and iodides. Reactions proceed smoothly at 80 degrees C in toluene in the presence of Cs(2)CO(3) to give synthetically versatile N-arylhydroxylamine products in good to excellent yield.
Porzelle
Achim
A
School of Chemistry, Main Building, Cardiff University, Park Place, Cardiff CF10 3AT, UK.
Woodrow
Michael D
MD
Tomkinson
Nicholas C O
NC
D002384:Catalysis; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry*; D006847:Hydrocarbons, Iodinated / Q000737:chemistry*; D006898:Hydroxylamines / Q000138:chemical synthesis* / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
D006842:Hydrocarbons, Brominated; D006843:Hydrocarbons, Chlorinated; D006847:Hydrocarbons, Iodinated; D006898:Hydroxylamines; D008024:Ligands; D010165:Palladium