title: Choleretic activity of 2-demethoxycarbonyl-2-ethoxycarbonyl-11-deoxymisoprostol on the model of CCl4-induced hepatitis.
abstract: Therapeutic administration of 11-deoxymisoprostol had a hepatoprotective effect, which manifested in a decrease in the content of alanine transaminase and aspartate transaminase in blood plasma, and produced a choleretic effect in rats with CCI4-induced toxic hepatitis.
authors.affiliation: Laboratory of New Medicinal Agents, Institute of Organic Chemistry, Ufa Research Center of the Russian Academy of Sciences, Ufa.
authors.forename: T A
authors.initials: TA
authors.lastname: Sapozhnikova
authors.forename: F S
authors.initials: FS
authors.lastname: Zarudii
authors.forename: N Zh
authors.initials: NZh
authors.lastname: Baschenko
authors.forename: S F
authors.initials: SF
authors.lastname: Gabdrahmanova
authors.forename: N S
authors.initials: NS
authors.lastname: Makara
authors.forename: R Yu
authors.initials: RY
authors.lastname: Khisamutdinova
authors.forename: N A
authors.initials: NA
authors.lastname: Ivanova
authors.forename: V S
authors.initials: VS
authors.lastname: Nazarov
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism; D002251:Carbon Tetrachloride / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000473:pathology; D002756:Cholagogues and Choleretics / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D016595:Misoprostol / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
chemical_list: C475855:2-demethoxycarbonyl-2-ethoxycarbonyl-11-deoxymisoprostol; D002756:Cholagogues and Choleretics; D016595:Misoprostol; D002251:Carbon Tetrachloride