Vitamin D receptor poly(A) microsatellite and colorectal cancer risk in Caucasians.
BACKGROUND
Colorectal cancer incidence and prognosis are influenced by vitamin D intake and expression of the vitamin D receptor (VDR). Polymorphisms of the VDR are linked to several diseases. This study was aimed to investigate whether variants of the VDR poly(A) microsatellite are associated with colorectal cancer incidence.


METHODS
The poly(A) polymorphism was analyzed in a series of 255 colorectal cancer patients and 255 controls of Caucasian origin (case-control study) by a combination of GeneScan and sequencing.


RESULTS
There was a distinct separation between long and short alleles. We found 19, 20, 21, and 22 A-repeats for the long variant and 14 and 15 A-repeats for the short variant. Frequencies of long and short alleles did not differ between cases and controls, nor did frequencies of any single variant.


CONCLUSIONS
Our findings do not support an association between VDR poly(A) variants and the incidence of colorectal cancer.
Flügge
Jana
J
Institute of Clinical Pharmacology and Toxicology, Charité-Universitätsmedizin Berlin, Charité Campus Mitte, Charitéplatz 1, 10117, Berlin, Germany.
Laschinski
Gabriele
G
Roots
Ivar
I
Krusekopf
Solveigh
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D015179:Colorectal Neoplasms / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D008875:Middle Aged; D011061:Poly A / Q000235:genetics*; D018167:Receptors, Calcitriol / Q000235:genetics*; D044465:White People / Q000235:genetics*
D018167:Receptors, Calcitriol; D011061:Poly A