RNAi Delivers Insights into Liver Cancer.
Of the myriad alterations in gene copy number found in cancer cells, which alterations are critical for the cancer phenotype? In this issue of Cell, Zender et al. (2008) describe an integrative genomics approach to identify new tumor suppressor genes involved in hepatocellular carcinoma.
Bernards
René
R
Division of Molecular Carcinogenesis, Center for Biomedical Genetics, and Cancer Genomics Center, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands. r.bernards@nki.nl
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D016147:Genes, Tumor Suppressor; D023281:Genomics; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D051379:Mice; D034622:RNA Interference