title: T serotypes and antimicrobial susceptibilities of group A streptococcus isolates from pediatric pharyngotonsillitis.
abstract: Group A streptococcus (GAS) is a major cause of pediatric pharyngotonsillitis. In this study we determined the T serotype and antimicrobial susceptibility of GAS isolates from Japanese children. From January to December 2006, a total of 438 isolates of GAS were obtained from pharyngeal swabs of 438 children with pharyngotonsillitis. The commonest T serotype was type 1 (110 strains, 25.1%), followed by type 12 (107, 24.4%) and type 4 (77, 17.6%). All GAS isolated from pharyngeal swabs were susceptible to beta-lactams (benzylpenicillin, amoxicillin, cefotaxime, ceftriaxone, imipenem, panipenem, and cefditoren) and vancomycin, but 19.6, 19.6, 3.2, 11.6, and 27.6% were resistant to erythromycin, clarithromycin, clindamycin, minocycline, and norfloxacin, respectively. Resistance varied considerably with the T serotype. In particular, type 4 isolates had the highest resistance (67.5, 67.5, 26.0, and 53.2% were resistant to erythromycin, clarithromycin, minocycline, and norfloxacin, respectively).
authors.affiliation: Department of Clinical Laboratory, Konan Kosei Hospital, Aichi, Japan. k-funahashi@konan.jaaikosei.or.jp
authors.forename: Keiji
authors.initials: K
authors.lastname: Funahashi
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Nakane
authors.forename: Naoko
authors.initials: N
authors.lastname: Yasuda
authors.forename: Michio
authors.initials: M
authors.lastname: Suzuki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Narita
authors.forename: Naoko
authors.initials: N
authors.lastname: Arai
authors.forename: Jaekun
authors.initials: J
authors.lastname: Ahn
authors.forename: Noriko
authors.initials: N
authors.lastname: Koyama
authors.forename: Hajime
authors.initials: H
authors.lastname: Ushida
authors.forename: Naoko
authors.initials: N
authors.lastname: Nishimura
authors.forename: Takao
authors.initials: T
authors.lastname: Ozaki
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D006801:Humans; D007223:Infant; D007564:Japan / Q000453:epidemiology; D008826:Microbial Sensitivity Tests; D010612:Pharyngitis / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology*; D012703:Serotyping; D013290:Streptococcal Infections / Q000276:immunology / Q000382:microbiology*; D013297:Streptococcus pyogenes / Q000145:classification* / Q000302:isolation & purification*; D014069:Tonsillitis / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents