title: Finasteride for prostatic disease: an updated and comprehensive review.
abstract: The development and introduction in clinical practice of finasteride, the first potent inhibitor of steroid 5-alpha-reductase that inhibits the conversion of testosterone to its active form dihydroxytestosterone, has created the possibility to prevent and treat prostatic disorder by manipulating and lowering the androgens levels in the prostate. Randomised and placebo-controlled trials have demonstrated the benefit of finasteride in men with enlarged prostatic gland owing to benign prostatic hyperplasia in terms of symptoms and urinary flow rate improvements. The Prostate Cancer Prevention Trial has clearly stated the chemopreventive properties of finasteride for prostate cancer but the necessity to provide such preventive therapy to a specific group of men with a higher risk to develop a clinically significant disease is under discussion. Finasteride is administered orally as a single daily dose. We recommend a 5 mg dose.
authors.affiliation: University 'La Sapienza', Department of Urology, Roma, Italy. cosimodenunzio@virgilio.it
authors.forename: Cosimo
authors.initials: C
authors.lastname: De Nunzio
authors.forename: Roberto
authors.initials: R
authors.lastname: Miano
authors.forename: Alberto
authors.initials: A
authors.lastname: Trucchi
authors.forename: Enrico
authors.initials: E
authors.lastname: Finazzi Agrò
authors.forename: Andrea
authors.initials: A
authors.lastname: Tubaro
mesh_terms: D058891:5-alpha Reductase Inhibitors; D000284:Administration, Oral; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D018120:Finasteride / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D015201:Meta-Analysis as Topic; D011469:Prostatic Diseases / Q000188:drug therapy* / Q000473:pathology; D016032:Randomized Controlled Trials as Topic
chemical_list: D058891:5-alpha Reductase Inhibitors; D004791:Enzyme Inhibitors; D018120:Finasteride