title: Four anti-protozoal and anti-bacterial compounds from Tapirira guianensis.
abstract: Tapirira guianensis is a common tree used in traditional medicine in French Guiana against several infectious diseases (malaria, leishmaniasis, bacteria, etc.). The bioassay-guided purification of CH(2)Cl(2) bark extract led to the isolation of four cyclic alkyl polyol derivatives: 4,6,2'-trihydroxy-6-[10'(Z)-heptadecenyl]-1-cyclohexen-2-one (1a), 1,4,6-trihydroxy-1,2'-epoxy-6-[10'(Z)-heptadecenyl]-2-cyclohexene (1b), 1,4,5,2'-tetrahydroxy-1-[10'(Z)-heptadecenyl]-2-cyclohexene (2), and 1,3,4,6-tetrahydroxy-1,2'-epoxy-6-[10'(Z)-heptadecenyl]-cyclohexane (3). The structures were established on the basis of 1D and 2D NMR analyses. The anti-leishmanial, anti-plasmodial, anti-bacterial (on Staphylococcus aureus, Staphylococcus epidermidis and Escherichia coli), and anti-fungal (on Candida albicans) activities of the extracts and of these original compounds were evaluated. Two showed medicinal interest supporting the traditional uses of the plant. The structures were established through spectral analyses of the isolates and their derivatives.
authors.affiliation: Université de Toulouse, UMR 152 IRD-Université Paul Sabatier, Toulouse 3, Faculté des Sciences Pharmaceutiques, 31062 Toulouse cedex 9, France. vincent.roumy@univ-lille2.fr
authors.forename: Vincent
authors.initials: V
authors.lastname: Roumy
authors.forename: Nicolas
authors.initials: N
authors.lastname: Fabre
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Portet
authors.forename: Geneviève
authors.initials: G
authors.lastname: Bourdy
authors.forename: Lucia
authors.initials: L
authors.lastname: Acebey
authors.forename: Claire
authors.initials: C
authors.lastname: Vigor
authors.forename: Alexis
authors.initials: A
authors.lastname: Valentin
authors.forename: Claude
authors.initials: C
authors.lastname: Moulis
mesh_terms: D027926:Anacardiaceae / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D050296:Microbial Viability / Q000187:drug effects; D015394:Molecular Structure
chemical_list: D000900:Anti-Bacterial Agents; D000981:Antiprotozoal Agents