Transient evoked otoacoustic emission latency and estimates of cochlear tuning in preterm neonates.
The latency of transient evoked otoacoustic emissions has been evaluated in a sample of 58 ears from 34 preterm neonates, to understand if the estimates of cochlear tuning based on the otoacoustic emission latency show signs of developmental changes. A previous study on the same otoacoustic emissions analyzed here [Tognola et al. (2005). "Cochlear maturation and otoacoustic emissions in preterm infants: A time-frequency approach," Hear. Res., 199, 71-80] reported indeed a significant change in the otoacoustic emission latency with postconception age. This last result, which would imply a significant decrease of tuning, was partially biased by the presence of spontaneous emissions. In this study, the same neonate data are reanalyzed using a novel time-frequency algorithm, less sensitive to spontaneous emissions. Asymmetry between right and left ears has been found, with the left ears showing no significant change, whereas in the right ears and in the 1.5-2.5 kHz frequency range only, a slow decrease of latency with postconception age (0.1-0.2 ms/week) was observed. The correspondent tuning estimates based on latency decrease by 0.4-0.5/week. Significant differences between neonate and adult latency were confirmed, which could be either cochlear or middle ear in nature. These findings are compared to previous studies on distortion product suppression tuning curves in preterm neonates.
Moleti
Arturo
A
Dipartimento di Fisica, Universita di Roma Tor Vergata, Via della Ricerca Scientifica, 1, 00133 Roma, Italy. arturo.moleti@roma2.infn.it
Sisto
Renata
R
Paglialonga
Alessia
A
Sibella
Federica
F
Anteunis
Lucien
L
Parazzini
Marta
M
Tognola
Gabriella
G
D000161:Acoustic Stimulation; D001300:Audiometry, Evoked Response; D003051:Cochlea / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D018072:Hair Cells, Auditory, Outer / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology*