Effect of body mass index on prostate-specific antigen and percentage free prostate-specific antigen: results from a prostate cancer screening cohort of 1490 men.
OBJECTIVE
Several studies have reported an effect of obesity, defined as elevated body mass index (BMI), on prostate cancer biology. We examined the relationship between BMI and total prostate-specific antigen (tPSA) as well as percent free tPSA (%f/tPSA) in a large prostate cancer screening cohort.


METHODS
Height, weight, tPSA and %f/tPSA were assessed in 1490 consecutively screened Canadian men without known prostate cancer. Continuously coded and categorized BMI were studied. Statistical analyses consisted of anova, linear regression and bivariate correlations, which adjusted for the effect of age.


RESULTS
Median tPSA was 1.06 ng/mL and median %f/tPSA was 27. Median BMI was 26.17 kg/m2. Increasing BMI was weakly, albeit statistically significantly, associated with decreasing %f/tPSA values (correlation coefficient = -0.06, P = 0.01). However, when the World Health Organization BMI categories were considered, there were no statistically significant differences between %f/tPSA values according to categories (anovaP = 0.2). tPSA failed to demonstrate any statistically significant association with either continuously coded (correlation coefficient = -0.03, P = 0.2) or categorized BMI (anovaP = 0.5).


CONCLUSIONS
Body mass index is not a confounder of either tPSA or %f/tPSA in Canadian men without known prostate cancer.
Capitanio
Umberto
U
Department of Urology, Vita-Salute University San Raffaele, Milan, Italy.
Perrotte
Paul
P
Hutterer
Georg C
GC
Suardi
Nazareno
N
Jeldres
Claudio
C
Shariat
Shahrokh F
SF
Duclos
Alain
A
Arjane
Philippe
P
Montorsi
Francesco
F
Karakiewicz
Pierre I
PI
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D015992:Body Mass Index; D002170:Canada; D015331:Cohort Studies; D006801:Humans; D016014:Linear Models; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000175:diagnosis*
D017430:Prostate-Specific Antigen