[Normal and abnormal pulmonary circulation].
Remodeling of the lung's vascular structure is the critical abnormality in the various types of pulmonary hypertension, including pulmonary arterial hypertension. Pulmonary hypertension consists of some structural changes and an adaptation to its presence (perhaps reversible component, including vasoconstriction). However, once pulmonary hypertension is a recognizable clinical problem, its basis is structural. The research for mediators of cell injury and tissue remodeling has been one of the most active fields of biomedical study. It offers an embarrassingly wide array of candidates for the cellular events. The normal structure of the lung's vascular bed holds the key to its remodeling. The cast of cells is similar at all levels of the pulmonary vascular bed, yet the various segments have special features and different patterns of response.
Tatsumi
Koichiro
K
Department of Respirology, Graduate School of Medicine, Chiba University.
D006801:Humans; D006976:Hypertension, Pulmonary / Q000473:pathology / Q000503:physiopathology*; D011651:Pulmonary Artery / Q000473:pathology; D011652:Pulmonary Circulation / Q000502:physiology*