title: Experimental and clinical study of the effect of artrofoon on proinflammatory cytokine production.
abstract: The effect of Artrofoon on the production of proinflammatory cytokines was evaluated in experiments on mice with collagen-induced arthritis and in a clinical study on patients with rheumatoid arthritis. Artrofoon produced an antiinflammatory effect on animals with collagen-induced arthritis and reduced clinical signs of inflammation in patients with rheumatoid arthritis. These changes were accompanied by a significant decrease in the production of tumor necrosis factor-alpha and interleukin-1beta.
authors.affiliation: Materia Medica Holding Research-and-Production Company, Moscow. kachanovamv@materiamedica.ru
authors.forename: M V
authors.initials: MV
authors.lastname: Kachanova
authors.forename: E Y
authors.initials: EY
authors.lastname: Sherstoboyev
authors.forename: A R
authors.initials: AR
authors.lastname: Babayeva
authors.forename: E V
authors.initials: EV
authors.lastname: Tcherevkova
authors.forename: J L
authors.initials: JL
authors.lastname: Dugina
authors.forename: O S
authors.initials: OS
authors.lastname: Kislitsyna
authors.forename: O I
authors.initials: OI
authors.lastname: Epstein
authors.forename: S A
authors.initials: SA
authors.lastname: Sergeeva
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use; D001169:Arthritis, Experimental / Q000188:drug therapy / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000276:immunology; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D053583:Interleukin-1beta / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; C503436:Artrofoon; D016207:Cytokines; D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha