Biochemical and functional properties of the store-operated Ca2+ channels.
Store-operated calcium entry (SOCE) is a major mechanism for Ca(2+) entry in excitable and non-excitable cells. The best-characterised store-operated current is I(CRAC), but other currents activated by Ca(2+) store depletion have also been reported. The recent identification of the proteins stromal interaction molecule 1 (STIM1) and Orai1 has shed new light on the nature and regulation of SOC channels. STIM1 has been presented as the endoplasmic reticulum (ER) Ca(2+) sensor that communicates the content of the Ca(2+) stores to the store-operated channels, a mechanism that involves redistribution of STIM1 to peripheral ER sites and co-clustering with the Ca(2+) channel subunit, Orai1. Interestingly, TRPC1, which has long been proposed as a SOC channel candidate, associates with Orai1 and STIM1 in a ternary complex that appears to increase the variability of SOC currents available to modulate cell function.
Salido
Ginés M
GM
Department of Physiology (Cell Physiology Research Group), University of Extremadura, Cáceres 10071, Spain.
Sage
Stewart O
SO
Rosado
Juan A
JA
D000818:Animals; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000145:classification / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D020013:Calcium Signaling / Q000187:drug effects / Q000502:physiology*; D002412:Cations / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000502:physiology; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology; D006801:Humans; D017136:Ion Transport / Q000187:drug effects / Q000502:physiology; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology; D046912:Multiprotein Complexes / Q000737:chemistry / Q000502:physiology; D009363:Neoplasm Proteins / Q000235:genetics / Q000502:physiology; D000071740:ORAI1 Protein; D000071741:ORAI2 Protein; D025941:Protein Interaction Mapping; D055503:Protein Multimerization; D016511:Severe Combined Immunodeficiency / Q000235:genetics; D000071737:Stromal Interaction Molecule 1; D000071738:Stromal Interaction Molecule 2; D050052:TRPC Cation Channels / Q000145:classification / Q000235:genetics / Q000502:physiology; D019284:Thapsigargin / Q000494:pharmacology
D015220:Calcium Channels; D002412:Cations; D015815:Cell Adhesion Molecules; D029721:Drosophila Proteins; D008565:Membrane Proteins; D046912:Multiprotein Complexes; D009363:Neoplasm Proteins; D000071740:ORAI1 Protein; C510746:ORAI1 protein, human; D000071741:ORAI2 Protein; C514506:ORAI2 protein, human; C522867:Orai3 protein, human; C103530:STIM1 protein, human; C513279:STIM2 protein, human; D000071737:Stromal Interaction Molecule 1; D000071738:Stromal Interaction Molecule 2; D050052:TRPC Cation Channels; C510747:olf186-F protein, Drosophila; D019284:Thapsigargin; D002118:Calcium