title: Case report: severe, symptomatic hypomagnesemia in acute leptospirosis.
abstract: We report a case of severe hypomagnesemia in non-oliguric acute renal failure caused by leptospirosis that required large doses of magnesium replacement during the acute phase of disease. Biochemical studies confirmed kidney-related magnesium wasting and the mechanisms of this defect are discussed. Magnesium imbalance with its attendant clinical complications occurs in leptospirosis and should be monitored and treated aggressively in cases of leptospirosis-induced non-oliguric acute kidney injury.
authors.affiliation: Department of Nephrology, University of São Paulo School of Medicine, and Department of Infectious Diseases, Heliopolis General Hospital, São Paulo, Brazil.
authors.forename: Anne
authors.initials: A
authors.lastname: Spichler
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Athanazio
authors.forename: Juvencio
authors.initials: J
authors.lastname: Furtado
authors.forename: Antonio
authors.initials: A
authors.lastname: Seguro
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Vinetz
mesh_terms: D000293:Adolescent; D005260:Female; D006801:Humans; D007922:Leptospirosis / Q000150:complications* / Q000188:drug therapy; D008275:Magnesium Deficiency / Q000097:blood* / Q000150:complications* / Q000188:drug therapy; D008278:Magnesium Sulfate / Q000627:therapeutic use; D009135:Muscular Diseases / Q000097:blood / Q000150:complications; D009996:Osmotic Fragility; D010400:Penicillin G / Q000627:therapeutic use; D011188:Potassium
chemical_list: D008278:Magnesium Sulfate; D010400:Penicillin G; D011188:Potassium