title: PEG-immobilization of cardol and soluble polymer-supported synthesis of some cardol-coumarin derivatives: preliminary evaluation of their inhibitory activity on mushroom tyrosinase.
abstract: In this work, the PEG-immobilization and the liquid phase synthesis of some coumarins derived from cardol are presented. Some preliminary results on their tyrosinase inhibitory activity are also included.
authors.affiliation: Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Cagliari, Cagliari, CA, Italy. toccog@unica.it
authors.forename: Graziella
authors.initials: G
authors.lastname: Tocco
authors.forename: Antonella
authors.initials: A
authors.lastname: Fais
authors.forename: Gabriele
authors.initials: G
authors.lastname: Meli
authors.forename: Michela
authors.initials: M
authors.lastname: Begala
authors.forename: Gianni
authors.initials: G
authors.lastname: Podda
authors.forename: M Benedetta
authors.initials: MB
authors.lastname: Fadda
authors.forename: Marcella
authors.initials: M
authors.lastname: Corda
authors.forename: Orazio A
authors.initials: OA
authors.lastname: Attanasi
authors.forename: Paolino
authors.initials: P
authors.lastname: Filippone
authors.forename: Stefano
authors.initials: S
authors.lastname: Berretta
mesh_terms: D000363:Agaricales / Q000201:enzymology*; D003374:Coumarins / Q000138:chemical synthesis* / Q000494:pharmacology*; D005656:Fungal Proteins; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D011092:Polyethylene Glycols; D011108:Polymers; D012118:Resorcinols / Q000737:chemistry*; D012995:Solubility
chemical_list: D003374:Coumarins; D005656:Fungal Proteins; D011108:Polymers; D012118:Resorcinols; D011092:Polyethylene Glycols; C030123:coumarin; D014442:Monophenol Monooxygenase; C041328:adipostatin A