A gut feeling for obesity: 7TM sensors on enteroendocrine cells.
Enteroendocrine cells, which secrete peptide hormones in response to sensation of food and gut microbiota products, can now be genetically tagged, isolated, cultured, and characterized for expression of the elusive chemosensors, as shown in publications in PNAS (Samuel et al., 2008) and in this issue (Reimann et al., 2008).
Engelstoft
Maja S
MS
Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Egerod
Kristoffer L
KL
Holst
Birgitte
B
Schwartz
Thue W
TW
D001647:Bile Acids and Salts / Q000378:metabolism; D019858:Enteroendocrine Cells / Q000378:metabolism / Q000502:physiology*; D005768:Gastrointestinal Hormones / Q000494:pharmacology; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism; D006801:Humans; D009765:Obesity / Q000188:drug therapy; D011956:Receptors, Cell Surface / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology*; D049368:Receptors, Lysophosphatidic Acid / Q000378:metabolism
D001647:Bile Acids and Salts; D005768:Gastrointestinal Hormones; D052216:Glucagon-Like Peptide 1; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D049368:Receptors, Lysophosphatidic Acid; C473103:FFAR2 protein, human; C473034:FFAR1 protein, human; C106262:FFAR3 protein, human; C519853:FFAR4 protein, human; C519854:GPR119 protein, human; C512992:LPAR5 protein, human