title: IgG4-related autoimmune pancreatitis involving the colonic mucosa.
abstract: We report a case of autoimmune pancreatitis involving the colonic mucosa. Although serum level of IgG4 was normal, computed tomography and endoscopic retrograde cholangiopancreatography showed diffuse enlargement of the pancreas and irregular narrowing of the pancreatic ducts, respectively. Colonoscopy revealed a polypoidal lesion in the ascending colon. A lymphoplasmacytic infiltration was seen both in the pancreas and in the polypoidal lesion of the colon. Furthermore, immunohistochemical analysis showed abundant IgG4-positive plasma cells in these lesions. This is the first case report of a simultaneous occurrence of autoimmune pancreatitis and a colonic polypoidal lesion, both of which are characterized with increased IgG4 responses.
authors.affiliation: Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Ueno
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Watanabe
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kawata
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Gotoh
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Tsuji
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ida
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Tada
authors.forename: Shujiro
authors.initials: S
authors.lastname: Yazumi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Chiba
mesh_terms: D000368:Aged; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D003111:Colonic Polyps / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000276:immunology; D008297:Male; D050500:Pancreatitis, Chronic / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D011239:Prednisolone / Q000627:therapeutic use
chemical_list: D005938:Glucocorticoids; D007074:Immunoglobulin G; D011239:Prednisolone