Treatment of tuberculosis in children.
The treatment of children with TB is influenced by a number of factors specific to both the bacterium and the child. We review the variables impacting the selection of individual medications; indications, pharmacology, dosing and side effects for first- and second-line agents; adjunctive therapy; and special cases, including treatment of TB in HIV-infected children and multidrug-resistant TB. Finally, evolving trends in TB therapy, such as the impact of HIV and multidrug-resistant TB on future therapeutics, emerging or re-emerging medication options, shorter-course regimens and immunomodulation, are discussed.
Cruz
Andrea T
AT
Texas Children's Hospital, MC 3-2371, 1102 Bates Street, Suite 1150, Houston, TX 77030, USA. acruz@bcm.edu
Starke
Jeffrey R
JR
D000293:Adolescent; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001942:Breast Feeding; D017024:Chemotherapy, Adjuvant; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D015658:HIV Infections / Q000150:complications; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011247:Pregnancy; D012307:Risk Factors; D014376:Tuberculosis / Q000150:complications / Q000188:drug therapy*
D000995:Antitubercular Agents