Distribution of ethomerzol in organ and tissue of rats after single and course treatment.
We studied experimental kinetics of ethomerzol (5-ethoxy-2ethylthiobenzimidazole hydrochloride) distribution in the liver, brain, kidneys, spleen, heart, skeletal muscles, lungs, adipose tissue, and testes of rats after its single or course administration. Peculiarities of ethomerzol distribution in various administration regimens were analyzed. Single treatment led to more pronounced accumulation of the drug in the liver. Study of ethomerzol distribution after course treatment revealed organs and tissues accumulating the drug (blood, brain, heart, kidneys, lungs, and adipose tissue).
Sergeeva
S A
SA
Russian Research Center for Safety of Bioactive Substances, Staraya Kupavna. nauka@materiamedica.ru
Gulyaeva
I L
IL
D000818:Animals; D001562:Benzimidazoles / Q000008:administration & dosage / Q000378:metabolism*; D008297:Male; D051381:Rats; D014018:Tissue Distribution
D001562:Benzimidazoles; C070941:ethomersol