title: Decreased intrathecal synthesis of prostaglandin D2 synthase in the cerebrospinal fluid of patients with acute inflammatory demyelinating polyneuropathy.
abstract: Prostaglandin D(2) synthase (PGDS) is the most abundant brain protein in cerebrospinal fluid (CSF) and is tied closely with inflammatory processes. This study investigated whether CSF PGDS levels in patients with acute inflammatory demyelinating polyneuropathy (AIDP) are altered. The results suggest that PGDS concentration is significantly increased in the CSF of AIDP patients compared with the control patients (p<0.05) due to a blood-CSF barrier dysfunction, whereas the intrathecal synthesis of PGDS, reflected by the CSF PGDS/albumin ratio, is significantly decreased in AIDP compared with the control group (p<0.05). The changes of CSF PGDS/albumin ratio are only observed in AIDP patients, but not in Miller Fisher Syndrome (MFS), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), or multiple sclerosis (MS) patients.
authors.affiliation: Department of Neurology, Chang Gung Memorial Hospital, Chang-Gung University College of Medicine, Taipei, Taiwan.
authors.forename: Yen-Chu
authors.initials: YC
authors.lastname: Huang
authors.forename: Rong-Kuo
authors.initials: RK
authors.lastname: Lyu
authors.forename: Mu-Yun
authors.initials: MY
authors.lastname: Tseng
authors.forename: Hong-Shiu
authors.initials: HS
authors.lastname: Chang
authors.forename: Wen-Chuin
authors.initials: WC
authors.lastname: Hsu
authors.forename: Hung-Chou
authors.initials: HC
authors.lastname: Kuo
authors.forename: Chun-Che
authors.initials: CC
authors.lastname: Chu
authors.forename: Yih-Ru
authors.initials: YR
authors.lastname: Wu
authors.forename: Long-Sun
authors.initials: LS
authors.lastname: Ro
authors.forename: Chin-Chang
authors.initials: CC
authors.lastname: Huang
authors.forename: Chiung-Mei
authors.initials: CM
authors.lastname: Chen
mesh_terms: D000328:Adult; D000418:Albumins / Q000134:cerebrospinal fluid; D015153:Blotting, Western; D005260:Female; D020275:Guillain-Barre Syndrome / Q000134:cerebrospinal fluid*; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000096:biosynthesis / Q000134:cerebrospinal fluid* / Q000235:genetics; D016014:Linear Models; D054834:Lipocalins / Q000096:biosynthesis / Q000134:cerebrospinal fluid* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D019846:Miller Fisher Syndrome / Q000134:cerebrospinal fluid; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000134:cerebrospinal fluid
chemical_list: D000418:Albumins; D054834:Lipocalins; D019746:Intramolecular Oxidoreductases; C022466:prostaglandin R2 D-isomerase