Metabolic effects of Trekrezan during adaptation of rats to intermittent hypoxic hypoxia.
The animals were adapted to intermittent hypoxic hypoxia in a flow pressure chamber for 3 days. Each one-day training session consisted of 4 elevations to an altitude of 6000 m for 20 min (15 m/sec, 20-min intervals between assents). Trekrezan (25 mg/kg intraperitoneally) was injected immediately after the end of daily training over 3 days. We showed that trekrezan increased the degree of adaptive metabolic changes in the brain, heart, and liver of rats during adaptation to hypoxic hypoxia.
Zarubina
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IV
Department of Pharmacology, Military Medical Academy, Russian Ministry of Defense, St. Petersburg.
D000064:Acclimatization / Q000187:drug effects; D000085:Acetates / Q000378:metabolism*; D000818:Animals; D001273:Atmosphere Exposure Chambers; D004338:Drug Combinations; D004734:Energy Metabolism / Q000187:drug effects; D004983:Ethanolamines / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000085:Acetates; D004338:Drug Combinations; D004983:Ethanolamines; C047413:crezacin