title: Redox balance following magnetic stimulation training in the quadriceps of patients with severe COPD.
abstract: In severe COPD patients, oxidative stress, which is involved in their peripheral muscle dysfunction, increases in response to exercise. In this study, muscle oxidative stress was explored after quadriceps magnetic stimulation training. A randomized controlled study was conducted on very severe COPD patients, who underwent quadriceps magnetic stimulation training for 8 weeks. A control group was also studied. In both groups, vastus lateralis specimens were obtained before and after the 8-week period. Muscle protein carbonylation and nitration and antioxidant enzymes were determined using immunoblotting and proportions and sizes of type I and II fibres using immunohistochemistry. Compared to controls, magnetic stimulation muscle training did not modify redox balance, whilst inducing a significant increase in type I fibre sizes. In severe COPD patients, it is concluded that quadriceps magnetic stimulation training was a well-tolerated therapeutic intervention, which did not enhance muscle oxidative stress, while increasing the size of slow-twitch fibres.
authors.affiliation: Basque Country University, Plaza Cruces s/n, Barakaldo, Pneumology Department, Cruces Hospital, Bizkaia, Basque Country, Spain.
authors.forename: Víctor
authors.initials: V
authors.lastname: Bustamante
authors.forename: Juan
authors.initials: J
authors.lastname: Casanova
authors.forename: Elena
authors.initials: E
authors.lastname: López de Santamaría
authors.forename: Sandra
authors.initials: S
authors.lastname: Mas
authors.forename: Jacobo
authors.initials: J
authors.lastname: Sellarés
authors.forename: Joaquim
authors.initials: J
authors.lastname: Gea
authors.forename: Juan B
authors.initials: JB
authors.lastname: Gáldiz
authors.forename: Esther
authors.initials: E
authors.lastname: Barreiro
mesh_terms: D000368:Aged; D002374:Catalase / Q000378:metabolism; D006801:Humans; D055909:Magnetic Field Therapy; D008280:Magnetics; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D029424:Pulmonary Disease, Chronic Obstructive / Q000378:metabolism* / Q000473:pathology; D052097:Quadriceps Muscle / Q000378:metabolism* / Q000473:pathology; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D002374:Catalase; D013482:Superoxide Dismutase