Serum indoxyl sulfate levels in patients with diabetic nephropathy: relation to renal function.
OBJECTIVE
To investigate the relationship between serum level of indoxyl sulfate, a tissue damaging factor, and renal function in type 2 diabetic patients.


METHODS
One hundred and sixty-three patients with type 2 diabetes and serum creatinine of 1.5mg/dL or below were studied. Serum indoxyl sulfate levels were measured, and general laboratory parameters and patient background were investigated. The relationship between serum indoxyl sulfate level and renal function was analyzed.


RESULTS
A strong negative correlation was observed between serum indoxyl sulfate level and renal function (estimated glomerular filtration rate) (r=-0.4355, p<0.001). Serum indoxyl sulfate also showed a significant positive correlation with serum creatinine and urea nitrogen, and a negative correlation with hematocrit and hemoglobin. When the patients were stratified by the estimated glomerular filtration rate, serum indoxyl sulfate was elevated in groups with estimated glomerular filtration rates of 60-89 mL/min/1.73 m(2) and below.


CONCLUSIONS
The present results demonstrate a clear correlation between serum indoxyl sulfate level and renal function, suggesting that the removal of indoxyl sulfate may be needed from the early stage of diabetic nephropathy.
Atoh
Keita
K
Department of Diabetology, Caress Alliance Nikko Memorial Hospital, Muroran-shi, Hokkaido, Japan.
Itoh
Hiroshi
H
Haneda
Masakazu
M
D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D003940:Diagnostic Techniques, Endocrine; D018450:Disease Progression; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007200:Indican / Q000097:blood*; D007668:Kidney / Q000503:physiopathology*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged
D007200:Indican