title: Evaluation of aspirin metabolites as inhibitors of hypoxia-inducible factor hydroxylases.
abstract: Known and potential aspirin metabolites were evaluated as inhibitors of oxygen-sensing hypoxia-inducible transcription factor (HIF) hydroxylases; some of the metabolites were found to stabilise HIF-alpha in cells.
authors.affiliation: The Department of Chemistry and the Oxford Centre for Integrative Systems Biology, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, United Kingdom.
authors.forename: Benoit M
authors.initials: BM
authors.lastname: Lienard
authors.forename: Ana
authors.initials: A
authors.lastname: Conejo-García
authors.forename: Ineke
authors.initials: I
authors.lastname: Stolze
authors.forename: Christoph
authors.initials: C
authors.lastname: Loenarz
authors.forename: Neil J
authors.initials: NJ
authors.lastname: Oldham
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Ratcliffe
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Schofield
mesh_terms: D001241:Aspirin / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D049308:Dioxygenases / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D015394:Molecular Structure; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D004791:Enzyme Inhibitors; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D049308:Dioxygenases; D001241:Aspirin