title: Effects of ginkgo biloba on testicle injury induced by diethylstilbestrol in mice.
abstract: To evaluate the effect of gingko biloba (EGb) on diethylstilbestrol (DES) induced testicle injury in mice. Fifty male mice were divided into a control group (A), DES group (B), and 3 EGb groups (C, D, E). The EGb-treated groups received peritoneal EGb at 8.75 (C), 17.5 (D), 35 mg/kg (E) BW daily for 7 days. The control group was given equivalent amount of normal saline. The mice in groups B, C, D and E were injected hypodermically with DES at 40 mg/kg BW daily 4 hours after the first herbal administration, while the control was given olive oil. Compared with DES group, the testis coefficients-relative testicular weight increased in the three EGb-treated groups. No significant difference was observed in epididymis coefficients. Lipid peroxidation status and antioxidant enzyme activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were significantly elevated in testes of EGb-treated groups. Lactate dehydrogenase (LDH) activities and malonaldehyde (MDA) contents were significantly decreased in testes of the EGb groups. The results indicate that EGb protects the testis from diethylstilbestrol-induced injury.
authors.affiliation: College of Animal Science and Veterinary Medicine, Agricultural University of Hebei, Baoding 071001, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Xiu-Hui
authors.initials: XH
authors.lastname: Zhong
authors.forename: Aituan
authors.initials: A
authors.lastname: Ma
authors.forename: Wanyu
authors.initials: W
authors.lastname: Shi
authors.forename: Xiao-Si
authors.initials: XS
authors.lastname: Zhang
authors.forename: Yuzhi
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000818:Animals; D000975:Antioxidants; D004054:Diethylstilbestrol; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D020441:Ginkgo biloba / Q000737:chemistry*; D005979:Glutathione Peroxidase / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D015227:Lipid Peroxidation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009929:Organ Size; D011897:Random Allocation; D013482:Superoxide Dismutase / Q000378:metabolism; D013733:Testicular Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D013737:Testis / Q000473:pathology
chemical_list: D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D004054:Diethylstilbestrol; D007770:L-Lactate Dehydrogenase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase