Pregnancy and catastrophic antiphospholipid syndrome.
Antiphospholipid syndrome (APS) is clearly related to maternal morbidity. The most characteristic feature is pregnancy loss; however, several other serious complications had been reported including fetal growth restriction, uteroplacental insufficiency, fetal distress, pre-eclampsia, and HELLP syndrome. Herein, we review the different aspects of obstetric APS features, with special emphasis on its life-threatening variant known as catastrophic APS (Asherson's syndrome) and its relationship with a thrombotic microangiopathy such as HELLP syndrome.
Gómez-Puerta
Jose A
JA
Rheumatology Department, Hospital Clínic, Barcelona, Spain. jagomez@clinic.ub.es
Sanin-Blair
Jose
J
Galarza-Maldonado
Claudio
C
D000022:Abortion, Spontaneous; D016736:Antiphospholipid Syndrome / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D005260:Female; D017359:HELLP Syndrome / Q000097:blood / Q000175:diagnosis / Q000276:immunology; D006487:Hemostasis / Q000276:immunology; D006801:Humans; D016491:Peripheral Vascular Diseases / Q000276:immunology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D013921:Thrombocytopenia / Q000276:immunology; D013927:Thrombosis / Q000276:immunology; D014327:Trophoblasts / Q000276:immunology* / Q000473:pathology*