title: Persistent urticaria characterized by recurrent lasting urticarial erythema with histological features of prominent perivascular eosinophilic infiltration.
abstract: We report a 29-year-old woman with a 15-year history of recurrent pruritic urticarial erythemas. The individual lesions lasted for > 24 h, and antihistaminic agents were not effective. Histological examination of a skin biopsy revealed interstitial oedema of the dermis and perivascular infiltration of numerous eosinophils without vasculitis. No internal organ involvement or peripheral blood eosinophilia was present. A diagnosis of persistent urticaria was made and the patient was successfully treated with oral corticosteroid therapy. Persistent urticaria has been described as an unusual reaction that lasts longer than typical urticaria. It is effectively treated with corticosteroids, but not with antihistaminic agents. In order to choose the most effective treatment, persistent urticaria should be recognized as a different clinical condition from typical urticaria.
authors.affiliation: Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan. hamano@showa.gunma-u.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Amano
authors.forename: Y
authors.initials: Y
authors.lastname: Nagai
authors.forename: O
authors.initials: O
authors.lastname: Ishikawa
mesh_terms: D000328:Adult; D001706:Biopsy; D004802:Eosinophilia / Q000473:pathology; D004890:Erythema / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D012008:Recurrence; D012867:Skin / Q000648:ultrastructure; D014581:Urticaria / Q000188:drug therapy / Q000473:pathology*
chemical_list: D005938:Glucocorticoids