title: Successful therapy with intravenous immunoglobulin in the management of polymyositis.
abstract: Polymyositis is an inflammation of muscle tissue of unknown etiology. It is characterized by symmetric, mainly proximal muscle weakness, muscle fiber damage proved on biopsy, increased enzymes and myoglobin, and has corresponding electromyography findings. Other systems such as joints, lungs, heart, and gastrointestinal system are involved. Lung involvement is rather common. The most frequent symptom represents shortness of breath caused by muscle weakness. We report a case of a 66 year old woman with primary idiopathic polymyositis. The clinical state of the patient was complicated by progressive muscle weakness, dysphagia, and respiratory failure. Due to the ineffectiveness of the treatment with corticsteroids and cyclophosphamide, treatment with high doses of immunoglobulins was started. A total of 100 g of i.v. immunoglobulin therapy was administered beginning on the 13th day after hospital admission. The state of the patient progressively improved and after 7 weeks of treatment in a significantly improved state the patient was transferred to a Rehabilitation Unit. We therefore conclude that IVIg therapy may be an effective therapeutic approach for the treatment of acute complications of polymyositis, especially in cases in whom other therapeutic strategies are ineffective or harmful (Ref. 10). Full Text (Free, PDF) www.bmj.sk.
authors.affiliation: 1st Department of Internal Medicine, Medical Faculty, University of Kosice, Slovakia. beatricae@hotmail.com
authors.forename: B
authors.initials: B
authors.lastname: Kristofova
authors.forename: M
authors.initials: M
authors.lastname: Oetterova
authors.forename: I
authors.initials: I
authors.lastname: Valocikova
authors.forename: Z
authors.initials: Z
authors.lastname: Macejova
authors.forename: A
authors.initials: A
authors.lastname: Pidanicova
authors.forename: J
authors.initials: J
authors.lastname: Firment
authors.forename: M
authors.initials: M
authors.lastname: Majernik
authors.forename: I
authors.initials: I
authors.lastname: Lazurova
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007155:Immunologic Factors / Q000627:therapeutic use*; D017285:Polymyositis / Q000628:therapy*
chemical_list: D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors