Out of the jaws of death: PRMT5 steers p53.
The tumour suppressor p53 triggers either cell-cycle arrest or apoptosis. Now, arginine methylation joins a panoply of other post-translational modifications that regulate p53. PRMT5 mediates p53 methylation, which disposes the cell to arrest rather than death.
Berger
Shelley L
SL
The Wistar Institute, Gene Expression & Regulation Program, 3601 Spruce Street, Room 201, Philadelphia, Pennsylvania 19104, USA. berger@wistar.org
D017209:Apoptosis; D001120:Arginine / Q000378:metabolism; D006801:Humans; D008745:Methylation; D011496:Protein Methyltransferases / Q000737:chemistry / Q000378:metabolism*; D011484:Protein-Arginine N-Methyltransferases; D013379:Substrate Specificity; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D016159:Tumor Suppressor Protein p53; D001120:Arginine; D011496:Protein Methyltransferases; C400529:PRMT5 protein, human; D011484:Protein-Arginine N-Methyltransferases