title: Diuretic renal scintigraphy in normal cats.
abstract: The purpose of this study was to develop a protocol for diuretic renal scintigraphy (renography) in cats and describe normal findings. 99mTc-DTPA renal scintigraphy was performed twice in 10 healthy cats. Furosemide or saline were injected 4.5 min after radiopharmaceutical administration for the diuretic or control scan, respectively. A dynamic acquisition was performed for 8 min. The following parameters were evaluated: (1) global and individual glomerular filtration rate (GFR); (2) shape of the time-activity curve (TAC); (3) time of peak (TOP); (4) individual kidney excretion half-time (T1/2) of the radiopharmaceutical; (5) percentage of maximum activity measured at the end of the study. Global GFR in the control studies (2.79 +/- 0.83 ml/min/kg, mean +/- SD) did not differ significantly from the diuretic scans (2.34 +/- 0.51 ml/min/kg). The shape of most (16/ 20) TAC of diuretic renograms was similar to those of control renograms. The TOP of the diuretic renogram curves was 3.06 +/- 0.58 min, and did not differ from that of the control scans (3.01 +/- 0.61 min). T1/2 of the diuretic renograms was significantly shorter (5.15 +/- 0.83 min) than that of the control renograms (6.31 +/- 1.50 min). A significantly lower percentage of maximum activity was present at the end of the study in diuretic renograms (median: 47.25%; range: 33.60-59.60%) compared with control renograms (63.40%; 30.00-69.40%). Diuretic renal scintigraphy is a noninvasive and fast procedure to perform in cats. The applicability of this technique needs to be investigated in patients with significantly impaired renal function and obstructive uropathies.
authors.affiliation: Department of Small Animal Clinical Sciences, University of Tennessee College of Veterinary Medicine, Knoxville, TN, USA. shecht@utk.edu
authors.forename: Silke
authors.initials: S
authors.lastname: Hecht
authors.forename: India F
authors.initials: IF
authors.lastname: Lane
authors.forename: Gregory B
authors.initials: GB
authors.lastname: Daniel
authors.forename: Federica
authors.initials: F
authors.lastname: Morandi
authors.forename: Dorothy E
authors.initials: DE
authors.lastname: Sharp
mesh_terms: D000818:Animals; D019540:Area Under Curve; D002371:Cat Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging; D002415:Cats / Q000033:anatomy & histology*; D004232:Diuretics; D005260:Female; D005665:Furosemide; D005919:Glomerular Filtration Rate / Q000662:veterinary; D007668:Kidney / Q000033:anatomy & histology* / Q000000981:diagnostic imaging* / Q000502:physiology; D008297:Male; D011866:Radioisotope Renography / Q000379:methods / Q000662:veterinary*; D011877:Radionuclide Imaging / Q000662:veterinary; D012016:Reference Values; D016284:Technetium Tc 99m Pentetate; D013997:Time Factors
chemical_list: D004232:Diuretics; D005665:Furosemide; D016284:Technetium Tc 99m Pentetate