Evaluation of chalcones--a flavonoid subclass, for, their anxiolytic effects in rats using elevated plus maze and open field behaviour tests.
The clinical applications of benzodiazepines as anxiolytics are limited because of their unwanted side effects. Therefore, the development of new pharmacological agents is well justified. Eight variably substituted chalcones were investigated for their effects on central nervous system if they have anxiolytic effects in rats. Anxiolytic effects of chalcones were also compared with standard anxiolytic drug (diazepam, DZP). Rats were injected intraperitoneally with chalcones, their derivatives and DZP for 3 days. Chalcones and their derivatives were injected at the dose of 25 mg/kg body weight and DZP was injected at the dose of 1 and 2 mg/kg body weight. Rats were then subjected to various anxiety paradigms including the open field behaviour and elevated plus maze tests. In addition, their effects on rota rod performance and grip strength were also examined. Variably substituted chalcones and DZP showed differential pattern of activities.
Jamal
Huma
H
Department of Chemistry, Aligarh Muslim University, Aligarh-202002, Uttar Pradesh, India. jamal_huma55555@yahoo.co.in
Ansari
Wajid Hussain
WH
Rizvi
Shamim Jahan
SJ
D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D047188:Chalcones / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D003975:Diazepam / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D015394:Molecular Structure; D009043:Motor Activity / Q000187:drug effects*; D053580:Muscle Strength / Q000187:drug effects; D011597:Psychomotor Performance / Q000187:drug effects; D051381:Rats; D045442:Rotarod Performance Test; D013329:Structure-Activity Relationship
D014151:Anti-Anxiety Agents; D047188:Chalcones; D003975:Diazepam