IgG4-related autoimmune pancreatitis involving the colonic mucosa.
We report a case of autoimmune pancreatitis involving the colonic mucosa. Although serum level of IgG4 was normal, computed tomography and endoscopic retrograde cholangiopancreatography showed diffuse enlargement of the pancreas and irregular narrowing of the pancreatic ducts, respectively. Colonoscopy revealed a polypoidal lesion in the ascending colon. A lymphoplasmacytic infiltration was seen both in the pancreas and in the polypoidal lesion of the colon. Furthermore, immunohistochemical analysis showed abundant IgG4-positive plasma cells in these lesions. This is the first case report of a simultaneous occurrence of autoimmune pancreatitis and a colonic polypoidal lesion, both of which are characterized with increased IgG4 responses.
Ueno
Kenji
K
Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Watanabe
Tomohiro
T
Kawata
Yukiko
Y
Gotoh
Tomoyuki
T
Tsuji
Yoshihisa
Y
Ida
Hiroshi
H
Tada
Shinsuke
S
Yazumi
Shujiro
S
Chiba
Tsutomu
T
D000368:Aged; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D003111:Colonic Polyps / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000276:immunology; D008297:Male; D050500:Pancreatitis, Chronic / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D011239:Prednisolone / Q000627:therapeutic use
D005938:Glucocorticoids; D007074:Immunoglobulin G; D011239:Prednisolone