title: Preparation of cefpodoxime proxetil fine particles using supercritical fluids.
abstract: Fine particles of cefpodoxime proxetil (CPD) were prepared using an Aerosol Solvent Extraction System (ASES) with supercritical CO(2). The resulting primary particles were approximately 0.1-0.2microm in size and were almost spherical in shape. The secondary particles were approximately 0.2-0.6microm in size and had irregular shapes. The larger particle size and irregular shapes were due to the agglomeration of the primary particles. The effects of solvent type, CO(2)-to-CPD solution weight ratio, and CPD solution concentration on the extent of agglomeration were investigated. As a result, the use of ethyl acetate and acetone as solvents also reduced the degree of agglomeration. The degree of agglomeration was reduced with the use of a high CO(2)-to-solution weight ratio, and a low solution concentration. In particular, spherical particles, approximately 0.1-0.4microm in size, were obtained when a 10.0wt% CPD solution was used. As a result of dissolution study, almost 90% of the processed CPD had dissolved within 10min. The recovery yield of the CPD powder reached approximately 80% using a membrane filter.
authors.affiliation: School of Chemical & Biological Engineering and Institute of Chemical Process, Seoul National University, San 56-1, Sillim-Dong, Gwanak-gu, 151-744, Seoul, Republic of Korea.
authors.forename: Junho
authors.initials: J
authors.lastname: Chu
authors.forename: Guanghua
authors.initials: G
authors.lastname: Li
authors.forename: Kyung Ho
authors.initials: KH
authors.lastname: Row
authors.forename: Hwayong
authors.initials: H
authors.lastname: Kim
authors.forename: Youn-Woo
authors.initials: YW
authors.lastname: Lee
mesh_terms: D000085:Acetates / Q000737:chemistry; D000096:Acetone / Q000737:chemistry; D000336:Aerosols; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002245:Carbon Dioxide / Q000737:chemistry; D015296:Ceftizoxime / Q000031:analogs & derivatives* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D008567:Membranes, Artificial; D010316:Particle Size; D011208:Powders; D012995:Solubility; D012997:Solvents / Q000737:chemistry*; D000097627:Cefpodoxime Proxetil
chemical_list: D000085:Acetates; D000096:Acetone; D000336:Aerosols; D000900:Anti-Bacterial Agents; D002245:Carbon Dioxide; D015296:Ceftizoxime; D008567:Membranes, Artificial; D011208:Powders; D012997:Solvents; D000097627:Cefpodoxime Proxetil; C007650:ethyl acetate