title: Optimal window of caloric restriction onset limits its beneficial impact on T-cell senescence in primates.
abstract: We have recently shown in non-human primates that caloric restriction (CR) initiated during adulthood can delay T-cell aging and preserve naïve CD8 and CD4 T cells into advanced age. An important question is whether CR can be initiated at any time in life, and whether age at the time of onset would modulate the beneficial effects of CR. In the current study, we evaluated the impact of CR started before puberty or during advanced age on T-cell senescence and compared it to the effects of CR started in early adulthood. Our data demonstrate that the beneficial effects of adult-onset CR on T-cell aging were lost by both early and late CR onset. In fact, some of our results suggest that inappropriate initiation of CR may be harmful to the maintenance of T-cell function. This suggests that there may be an optimal window during adulthood where CR can delay immune senescence and improve correlates of immunity in primates.
authors.affiliation: Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR, USA.
authors.forename: Ilhem
authors.initials: I
authors.lastname: Messaoudi
authors.forename: Miranda
authors.initials: M
authors.lastname: Fischer
authors.forename: Jessica
authors.initials: J
authors.lastname: Warner
authors.forename: Buyng
authors.initials: B
authors.lastname: Park
authors.forename: Julie
authors.initials: J
authors.lastname: Mattison
authors.forename: Donald K
authors.initials: DK
authors.lastname: Ingram
authors.forename: Thomas
authors.initials: T
authors.lastname: Totonchy
authors.forename: Motomi
authors.initials: M
authors.lastname: Mori
authors.forename: Janko
authors.initials: J
authors.lastname: Nikolich-Zugich
mesh_terms: D000367:Age Factors; D000375:Aging / Q000276:immunology / Q000378:metabolism; D000818:Animals; D031204:Caloric Restriction; D002478:Cells, Cultured; D016922:Cellular Senescence / Q000276:immunology / Q000502:physiology*; D005260:Female; D016130:Immunophenotyping; D008253:Macaca mulatta; D008297:Male; D011323:Primates / Q000276:immunology / Q000378:metabolism*; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology / Q000378:metabolism*