Have hair follicle stem cells shed their tranquil image?
In a recent issue of Nature Genetics, Jaks et al. (2008) demonstrate that hair follicle cells expressing the intestinal stem cell marker Lgr5 are hair follicle epithelial stem cells. In contrast to the established bulge stem cell population, Lrg5(+) cells are actively cycling and reside in part outside the bulge.
Lin
Kevin K
KK
Department of Medicine, University of California, Irvine, CA 92697-4030, USA.
Andersen
Bogi
B
D053687:Adult Stem Cells / Q000166:cytology / Q000378:metabolism*; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002454:Cell Differentiation / Q000235:genetics; D019070:Cell Lineage / Q000235:genetics*; D049109:Cell Proliferation; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism*; D018859:Hair Follicle / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D039902:Multipotent Stem Cells / Q000166:cytology / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism*
D015415:Biomarkers; C493597:Lgr5 protein, mouse; D043562:Receptors, G-Protein-Coupled