title: [Roles of angiopoietins family and its receptor in the pathogenesis and regulation of corneal neovascularization].
abstract: Corneal neovascularization is one of the tough problems in the cornea diseases, but its pathogenesis is still unclear. Binding of angiopoietins family and its receptor Tie2 set up the signal transducing system of Ang/Tie2, which plays the important role in the angiogenesis and regulation. Recently, the study of the signal transducing system of Ang/Tie2 has archived some progression in the corneal neovascularization. So this article reviewed the advances of related role of angiopoietins family and its receptor in the pathogenesis and regulation of corneal neovascularization including the structure and function of angiopoietins and its receptor Tie2.
authors.affiliation: Department of Ophthalmology, Eye Ear Nose and Throat Hospital of Fudan University, Shanghai, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Wen-Tao
authors.initials: WT
authors.lastname: Wang
authors.forename: Jian-Jiang
authors.initials: JJ
authors.lastname: Xu
authors.forename: Jia-Xu
authors.initials: JX
authors.lastname: Hong
mesh_terms: D042682:Angiopoietins / Q000378:metabolism*; D016510:Corneal Neovascularization / Q000473:pathology*; D042787:Receptor, TIE-2 / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D042682:Angiopoietins; D042787:Receptor, TIE-2