[Association of genetic polymorphisms in selenoprotein GPX1 and TXNRD2 with genetic susceptibility of gastric cancer].
OBJECTIVE
This study examined whether the two polymorphisms of GPX1 (198Pro--> Leu) and TXNRD2 (370Lys-->Arg) contributed alone or in combination, to the risk of gastric cancer development.


METHODS
A total of 361 patients with gastric cancer and 363 cancer-free controls were recruited and their genotypes of the two polymorphisms were determined by polymerase chain reaction-based restrictive fragment length polymorphism (PCR-RFLP) method. Odds ratio (OR) and 95% confidence interval (CI) were computed using unconditional logistic regression model.


RESULTS
GPX1 and TXNRD2 polymorphisms individually were not associated with the risk of gastric cancer. Gene-gene interaction of GPX1 and TXNRD2 polymorphisms decreased the risk of gastric cancer. Carrying the protective genotype might decrease the risk at 62% (OR = 0.38, 95% CI = 0.26-0.55, P < 0.001) as compared with the risk genotype.


CONCLUSIONS
The GPX1 198 Pro/Pro and TXNRD2 370Arg/Arg genotypes might be associated with the genetic susceptibility of gastric cancer.
Wang
Jia
J
Department of Nutrition and Food Hygiene, Peking University Health Science Center, Beijing 100083, China.
Sun
Tong
T
Yang
Ming
M
Lin
Dong-Xin
DX
Tan
Wen
W
Li
Ke-Ji
KJ
Xiao
Ying
Y
D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005979:Glutathione Peroxidase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D013274:Stomach Neoplasms / Q000235:genetics*; D054482:Thioredoxin Reductase 2 / Q000235:genetics*; D000094765:Glutathione Peroxidase GPX1
D005979:Glutathione Peroxidase; C516127:TXNRD2 protein, human; D054482:Thioredoxin Reductase 2; D000094765:Glutathione Peroxidase GPX1; C000722067:GPX1 protein, human