title: Esophageal motility in nonacid reflux compared with acid reflux.
abstract: Esophageal motility has been well studied in gastroesophageal reflux disease (GERD) and acid reflux, but not in nonacid reflux. Consecutive patients who had both 24-h multichannel intraluminal impedance-pH (MII-pH) and esophageal motility tests for suspected GERD were studied. Patients were grouped into nonacid refluxers, acid refluxers, and nonrefluxers based on positive symptom correlation and objective findings of acid reflux. Of 96 patients enrolled, 21 patients (22%) were nonacid refluxers, 44 patients (46%) were acid refluxers, and 31 patients (32%) had no objective evidence of reflux. Normal motility was recorded in 86% of nonacid refluxers, 71% of acid refluxers, and 60% of nonrefluxers. Ineffective esophageal motility was seen in 24% of acid refluxers, and 5% of nonacid refluxers (P = 0.11). Symptomatic nonacid reflux events comprised 22% of patients studied for GERD symptoms by MII-pH. Esophageal motility in nonacid reflux is normal 86% of the time.
authors.affiliation: Division of Gastroenterology and Hepatology, Brigham and Women's Hospital, Boston 02115, MA, USA.
authors.forename: Victor S
authors.initials: VS
authors.lastname: Wang
authors.forename: Natan
authors.initials: N
authors.lastname: Feldman
authors.forename: Rie
authors.initials: R
authors.lastname: Maurer
authors.forename: Robert
authors.initials: R
authors.lastname: Burakoff
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D050782:Esophageal pH Monitoring; D004942:Esophagitis, Peptic / Q000503:physiopathology; D004947:Esophagus / Q000503:physiopathology*; D005260:Female; D005764:Gastroesophageal Reflux / Q000503:physiopathology*; D005769:Gastrointestinal Motility; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies