TRAIL-enhancing activity of Erythrinan alkaloids from Erythrina velutina.
A new Erythrinan alkaloid (1), erythodine N-oxide, was isolated from the seeds of Erythrina velutina together with seven known Erythrinan alkaloids (2-7, 9) and an indole alkaloid (8). The structure of new compound (1) was elucidated by spectroscopic methods. Six of the nine compounds showed enhanced activity when combined with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Erysotrine (4) did not show cytotoxic activity by itself, but exhibited significant cytotoxicity when combined with TRAIL.
Ozawa
Masaaki
M
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Kanda, Tokyo, Japan.
Etoh
Tadahiro
T
Hayashi
Masahiko
M
Komiyama
Kanki
K
Kishida
Akio
A
Ohsaki
Ayumi
A
D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D000970:Antineoplastic Agents; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004357:Drug Synergism; D004895:Erythrina / Q000737:chemistry*; D006801:Humans; D026121:Indole Alkaloids; D019169:Jurkat Cells; D015394:Molecular Structure; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000494:pharmacology* / Q000627:therapeutic use
D000470:Alkaloids; D000970:Antineoplastic Agents; D026121:Indole Alkaloids; D053221:TNF-Related Apoptosis-Inducing Ligand