title: [Gene therapy and cell therapy for idiopathic pulmonary arterial hypertension].
abstract: Idiopathic pulmonary arterial hypertension is a rare, but severe disease with high mortality. The endothelial dysfunction is a major pathogenesis of pulmonary arterial hypertension. Gene therapy, cell therapy and their combination therapy are developed to improve pulmonary hypertension by restoring the impaired endothelial function or regenerating endothelial cells. Although these therapies are still in experimental stage, they might be promising for pulmonary arterial hypertension. Here, we review the characteristics of the gene therapy, the cell therapy and the combination of them.
authors.affiliation: Department of Internal Medicine, Division of Cardio-Vascular Medicine, Kurume University School of Medicine.
authors.forename: Kiyoko
authors.initials: K
authors.lastname: Takemiya
authors.forename: Hisashi
authors.initials: H
authors.lastname: Kai
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Imaizumi
mesh_terms: D000818:Animals; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D015316:Genetic Therapy / Q000379:methods*; D006976:Hypertension, Pulmonary / Q000628:therapy*