title: 3q27 aberrations in a childhood ovary teratoma with associated malignant germ cell component.
abstract: Cytogenetic studies of childhood ovary tumors have been poorly described. In the present article, the cytogenetic findings of an ovarian teratoma with malignant germ cell (yolk-sac) component occurring in an 8-year-old female are detailed. GTG-banding showed a karyotype of 46,XX, t(3;20)(q27;q13.3) [4]/46,XX, del3q27 [3]/46,XX [30]. Previous studies have demonstrated common sites of loss of heterozygosity at 3q27-q28 region in different types of cancer, suggesting the presence of tumor suppressor genes within this region.
authors.affiliation: Department of Pediatrics, Radiology Division, Division of Pediatric Oncology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil. marsol@rge.fmrp.usp.br
authors.forename: María Sol
authors.initials: MS
authors.lastname: Brassesco
authors.forename: Angel Mauricio
authors.initials: AM
authors.lastname: Castro-Gamero
authors.forename: Elvis Terci
authors.initials: ET
authors.lastname: Valera
authors.forename: Luciano
authors.initials: L
authors.lastname: Neder
authors.forename: Jorge
authors.initials: J
authors.lastname: Elias
authors.forename: Luiz Gonzaga
authors.initials: LG
authors.lastname: Tone
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020360:Neoadjuvant Therapy; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000235:genetics* / Q000601:surgery; D011859:Radiography; D012729:Sex Chromosome Aberrations; D013724:Teratoma / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000235:genetics* / Q000601:surgery