title: Salvage paclitaxel chemotherapy for metastatic collecting duct carcinoma of the kidney.
abstract: We report a case of metastatic collecting duct carcinoma (CDC) incidentally found on computer assisted tomography in an 18-year-old male who presented status post a motor vehicle crash (MVC). The patient underwent total nephrectomy/renal vein thrombectomy with retroperitoneal lymph node dissection, followed by multimodal therapy, with gemcitabine and platinum salt therapy, effecting a short lived complete response, followed by single agent paclitaxel chemotherapy effecting a similarly short lived partial response. We conclude that cytoreductive nephrectomy and lymphadenectomy combined with chemotherapy may be useful for extending and increasing the quality of life of selected patients with CDC.
authors.affiliation: Department of Urology, University of Tennessee Health Sciences Center, Memphis, Tennessee 38163, USA.
authors.forename: Aditya
authors.initials: A
authors.lastname: Bagrodia
authors.forename: Robert
authors.initials: R
authors.lastname: Gold
authors.forename: Charles
authors.initials: C
authors.lastname: Handorf
authors.forename: Andrew
authors.initials: A
authors.lastname: Liman
authors.forename: Ithaar H
authors.initials: IH
authors.lastname: Derweesh
mesh_terms: D000293:Adolescent; D002292:Carcinoma, Renal Cell / Q000188:drug therapy* / Q000556:secondary* / Q000601:surgery; D003131:Combined Modality Therapy; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D008297:Male; D017239:Paclitaxel / Q000627:therapeutic use*; D016879:Salvage Therapy
chemical_list: D017239:Paclitaxel