title: Co-administration of Radix curcumae alters the tissue distribution of danshensu in Radix salviae miltiorrhiae in rabbits.
abstract: The tissue distribution profile of danshensu, one of the bioactive components in Radix salviae miltiorrhiae, was investigated after oral administration of Radix salviae miltiorrhiae coupled with Radix curcumae in rabbits. Eighteen rabbits were evenly divided into 3 groups. Rabbits of the groups were orally administrated with carboxymethyl cellulose, Radix salviae miltiorrhiae (10.0 g/kg) and Radix salviae miltiorrhiae (10.0 g/kg) coupled with Radix curcumae (5.0 g/kg), respectively. High performance liquid chromatography-electrospray ionic trap mass spectrometry (HPLC-ESI-MS(n)) was used for the determination of danshensu in the tissues including heart, liver, kidney and brain. The statistical results demonstrated that the characteristic profiles of danshensu were c(kidney) > c(heart) > c(liver) > c(brain) and c(kidney) > c(brain) > c(liver) > c(heart) after administration of Radix salviae miltiorrhiae and Radix salviae miltiorrhiae coupled with Radix curcumae, respectively, indicating that Radix curcumae could obviously increase the concentration of danshensu in brain. This result would provide substantial foundation for the harmonizing effect of shi herb in a Chinese compound prescription.
authors.affiliation: Engineering and Research Center of Chinese Herb Modernization, Northwest University, Xi'an 710069, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: Xinfeng
authors.initials: X
authors.lastname: Zhao
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Minfeng
authors.initials: M
authors.lastname: Fang
authors.forename: Wenji
authors.initials: W
authors.lastname: Sun
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Zheng
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D030024:Curcuma / Q000737:chemistry / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000378:metabolism / Q000493:pharmacokinetics*; D005260:Female; D007773:Lactates / Q000378:metabolism / Q000493:pharmacokinetics*; D008297:Male; D011817:Rabbits; D011897:Random Allocation; D027561:Salvia miltiorrhiza / Q000737:chemistry / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D004365:Drugs, Chinese Herbal; D007773:Lactates; C035055:3,4-dihydroxyphenyllactic acid