Cutaneous metastasis of extraskeletal osteosarcoma arising in the mediastinum.
Cutaneous metastases have been reported in 5%-10% of patients with internal malignancy. The most common clinical features are the sudden appearance of discrete, firm, and nontender nodules in a particular area of the body. The most frequent metastatic site of extraskeletal osteosarcoma (ESOS) is the lungs. Cutaneous metastasis of ESOS is rare. To our knowledge, only one case of ESOS has been reported with skin metastasis, histopathologically classified as the osteoblastic subtype. Here, we describe a case of chondroblastic ESOS arising in the mediastinum with metastasis to the skin. Our patient presented with a scalp nodule after diagnosis of primary ESOS at the mediastinum.
Lee
Woo Jin
WJ
Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Lee
Deok Woo
DW
Chang
Sung Eun
SE
Lee
Mi Woo
MW
Choi
Jee Ho
JH
Moon
Kee Chan
KC
Koh
Jai Kyoung
JK
D005260:Female; D006801:Humans; D008479:Mediastinal Neoplasms / Q000473:pathology*; D008875:Middle Aged; D012516:Osteosarcoma / Q000175:diagnosis* / Q000556:secondary*; D012535:Scalp; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000556:secondary*