Posttranslational regulation of cell-surface colony-stimulating factor-1.
Colony-stimulating factor-1 (CSF-1) plays a central role in the survival, proliferation, differentiation, and function of monocytes and macrophages. CSF-1 is synthesized as both a soluble and a membrane-spanning growth factor. The membrane-spanning isoform is biologically active, but it can also be proteolytically cleaved to generate a soluble growth factor. A recent study revealed that the TNF-alpha-converting enzyme is involved in this activity, and, moreover, that membrane-spanning CSF-1 undergoes internalization. These findings may have important implications for the posttranslational regulation and the functions of cell-surface CSF-1.
Horiuchi
Keisuke
K
Department of Anti-aging Orthopedic Research, Keio University, School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan. horiuchi@z3.keio.jp
Toyama
Yoshiaki
Y
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D016173:Macrophage Colony-Stimulating Factor / Q000276:immunology* / Q000378:metabolism; D008264:Macrophages / Q000276:immunology* / Q000378:metabolism; D008969:Molecular Sequence Data; D009000:Monocytes / Q000276:immunology* / Q000378:metabolism; D014176:Protein Biosynthesis; D020033:Protein Isoforms / Q000276:immunology / Q000378:metabolism; D016415:Sequence Alignment; D016211:Transforming Growth Factor alpha / Q000276:immunology* / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology* / Q000378:metabolism
D020033:Protein Isoforms; D016211:Transforming Growth Factor alpha; D014409:Tumor Necrosis Factor-alpha; D016173:Macrophage Colony-Stimulating Factor