Prostate cancer stem cells.
Despite the discovery over 60 years ago by Huggins and Hodges that prostate cancers respond to androgen deprivation therapy, hormone-refractory prostate cancer remains a major clinical challenge. There is now mounting evidence that solid tumours originate from undifferentiated stem cell-like cells coexisting within a heterogeneous tumour mass that drive tumour formation, maintain tumour homeostasis and initiate metastases. This review focuses upon current evidence for prostate cancer stem cells, addressing the identification and properties of both normal and transformed prostate stem cells.
Lang
S H
SH
YCR Cancer Research Unit, Department of Biology, University of York, UK.
Frame
F M
FM
Collins
A T
AT
D000818:Animals; D002471:Cell Transformation, Neoplastic; D006801:Humans; D008297:Male; D023421:Models, Animal; D014411:Neoplastic Stem Cells / Q000473:pathology*; D011467:Prostate / Q000166:cytology; D011471:Prostatic Neoplasms / Q000473:pathology*; D055153:Stem Cell Niche; D013234:Stem Cells / Q000166:cytology