title: Solubilisation of griseofulvin in aqueous micellar solutions of diblock copolymers of ethylene oxide and 1,2-butylene oxide with lengthy B-blocks.
abstract: The influence of hydrophobic-block length on solubilisation capacity was examined for micelles of E(m)B(n) copolymers (E=oxyethylene, B=oxybutylene, subscripts denote number-average block lengths in repeat units) with B-block lengths in the range of 30-76 and with E-blocks of sufficient length to ensure the formation of spherical micelles. Griseofulvin was used as a model poorly-water-soluble drug known to be almost exclusively solubilised in the micellar core. Combination of solubilisation data with those of a previous study has shown that the amount of drug solubilised per gram of hydrophobe is essentially independent of B-block length when this exceeds about 15 B units, suggesting that core size is not a major influence on solubilisation.
authors.affiliation: Department of Organic and Inorganic Chemistry, Polymer Laboratory, Federal University of Ceará, CX 12.200, CEP 60455-760, Fortaleza, Ceará, Brazil.
authors.forename: Maria Elenir N P
authors.initials: ME
authors.lastname: Ribeiro
authors.forename: Igor Marques
authors.initials: IM
authors.lastname: Cavalcante
authors.forename: Nágila M P S
authors.initials: NM
authors.lastname: Ricardo
authors.forename: Shao-Min
authors.initials: SM
authors.lastname: Mai
authors.forename: David
authors.initials: D
authors.lastname: Attwood
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Yeates
authors.forename: Colin
authors.initials: C
authors.lastname: Booth
mesh_terms: D004852:Epoxy Compounds / Q000737:chemistry*; D005027:Ethylene Oxide / Q000737:chemistry*; D006118:Griseofulvin / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008823:Micelles; D011108:Polymers / Q000737:chemistry; D012995:Solubility
chemical_list: D004852:Epoxy Compounds; D008823:Micelles; D011108:Polymers; C027488:1,2-epoxybutane; D006118:Griseofulvin; D005027:Ethylene Oxide