title: Complete NMR assignment and absolute configuration of feronielloside, a new acetylcholinesterase inhibitor from Feroniella lucida.
abstract: Feronielloside (1), a new furanocoumarin glycoside, was isolated from roots of Feroniella lucida. The structure of 1 was elucidated by combined spectroscopic and chemical analysis. The absolute configuration of the chiral center in geranyl-derived side chain was confirmed by modified Mosher's method. Feronielloside inhibited acetylcholinesterase with IC(50) value of 24.7 mM.
authors.affiliation: Natural Products Research Unit, Department of Chemistry, Chulalongkorn University, Bangkok, Thailand.
authors.forename: Chalouyluk
authors.initials: C
authors.lastname: Phoopichayanun
authors.forename: Preecha
authors.initials: P
authors.lastname: Phuwapraisirisan
authors.forename: Santi
authors.initials: S
authors.lastname: Tip-Pyang
authors.forename: Jongkolnee
authors.initials: J
authors.lastname: Jongaramruong
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D027821:Rutaceae / Q000737:chemistry*; D013785:Thailand
chemical_list: D002800:Cholinesterase Inhibitors; D003374:Coumarins; D005663:Furans; D006027:Glycosides; C533509:feronielloside; D000110:Acetylcholinesterase