title: Immunoglobulin and cytokine production from mesenteric lymph node lymphocytes is regulated by extracts of Cordyceps sinensis in C57Bl/6N mice.
abstract: Cordyceps sinensis, one of the well-known fungi used in traditional Chinese medicine, is recognized to play a role in the metabolic process of inflammation and immunity. The purpose of this study was to evaluate the effects of water extracts of C. sinensis on the immune function of mesenteric lymph node (MLN) lymphocytes in C57Bl/6N mice. C. sinensis-treated mice were administered the respective extract by oral gavage for 4 weeks. Immunoglobulin E concentrations in serum and MLN lymphocytes were significantly lower in C. sinensis-treated mice than in control mice. In contrast, the immunoglobulin A concentration from the C. sinensis group was higher than that in control mice. C. sinensis increased the proportion of CD4(+) and CD8(+) T cells in MLN lymphocytes. C. sinensis significantly decreased interleukin-4 and interleukin-10 cytokine concentrations. Therefore, water extracts of C. sinensis modulate immune parameters through regulation of immunoglobulin production resulting from decreased T-lymphocyte helper 2 cytokine secretion and reduce cytokine secretion in MLN lymphocytes.
authors.affiliation: Department of Applied Biology and Chemistry, Konkuk University, Seoul, Republic of Korea.
authors.forename: Dong Ki
authors.initials: DK
authors.lastname: Park
authors.forename: Wahn Soo
authors.initials: WS
authors.lastname: Choi
authors.forename: Pyo-Jam
authors.initials: PJ
authors.lastname: Park
authors.forename: Eun Kyung
authors.initials: EK
authors.lastname: Kim
authors.forename: Yong Jun
authors.initials: YJ
authors.lastname: Jeong
authors.forename: Se Young
authors.initials: SY
authors.lastname: Choi
authors.forename: Koji
authors.initials: K
authors.lastname: Yamada
authors.forename: Jong Dai
authors.initials: JD
authors.lastname: Kim
authors.forename: Beong Ou
authors.initials: BO
authors.lastname: Lim
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D032661:Cordyceps / Q000737:chemistry*; D016207:Cytokines / Q000096:biosynthesis*; D007070:Immunoglobulin A / Q000096:biosynthesis* / Q000097:blood; D007074:Immunoglobulin G / Q000096:biosynthesis* / Q000097:blood; D007155:Immunologic Factors / Q000494:pharmacology*; D008198:Lymph Nodes / Q000187:drug effects / Q000378:metabolism; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008643:Mesentery; D051379:Mice; D008810:Mice, Inbred C57BL; D010936:Plant Extracts / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000187:drug effects / Q000378:metabolism
chemical_list: D016207:Cytokines; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007155:Immunologic Factors; D010936:Plant Extracts