title: Diffuse optical tomography of the breast: initial validation in benign cysts.
abstract: OBJECTIVE
  The purpose of this study was to validate a newly developed diffuse optical tomography (DOT) system on benign cysts in the breast.
  
  
  METHODS
  Eight patients with 20 benign cysts were included. Study procedures consisted of optical breast imaging and breast magnetic resonance imaging (MRI) for comparison. A reconstruction algorithm computed three-dimensional images for each of the four near-infrared wavelengths used by our DOT system (Philips Healthcare, Best, The Netherlands). These images were combined using a spectroscopic model to assess tissue composition and lesion size.
  
  
  RESULTS
  Twenty cysts were analyzed in eight patients. By using the spectroscopic information, 13 of 20 cysts (65%) were visualized with DOT, confirming their high water and low total hemoglobin content. Lesion size and location showed good agreement with MRI; Pearson correlation coefficient was 0.7 (p < 0.01).
  
  
  CONCLUSIONS
  DOT can visualize benign cysts in the breast and elucidate their high water and low total hemoglobin content by spectroscopic analysis.
authors.affiliation: Radiology, University Medical Center Utrecht, Utrecht, the Netherlands. s.m.w.y.vandeven-2@umcutrecht.nl
authors.forename: Stephanie
authors.initials: S
authors.lastname: van de Ven
authors.forename: Sjoerd
authors.initials: S
authors.lastname: Elias
authors.forename: Andrea
authors.initials: A
authors.lastname: Wiethoff
authors.forename: Marjolein
authors.initials: M
authors.lastname: van der Voort
authors.forename: Anais
authors.initials: A
authors.lastname: Leproux
authors.forename: Tim
authors.initials: T
authors.lastname: Nielsen
authors.forename: Bernhard
authors.initials: B
authors.lastname: Brendel
authors.forename: Leon
authors.initials: L
authors.lastname: Bakker
authors.forename: Martin
authors.initials: M
authors.lastname: van der Mark
authors.forename: Willem
authors.initials: W
authors.lastname: Mali
authors.forename: Peter
authors.initials: P
authors.lastname: Luijten
mesh_terms: D000328:Adult; D000465:Algorithms; D001940:Breast / Q000473:pathology*; D047688:Breast Cyst / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged; D015203:Reproducibility of Results; D013057:Spectrum Analysis; D041622:Tomography, Optical / Q000379:methods*
chemical_list: D006454:Hemoglobins