Multifidone: a novel cytotoxic lathyrane-type diterpene having an unusual six-membered A ring from Jatropha multifida.
Chemical examination of the stems of Jatropha multifida afforded a novel lathyrane-type diterpene, multifidone, having an unusual six-membered A ring. The structure of the compound was determined from detailed analysis of its 1D and 2D NMR spectra and X-ray crystallographic analysis. Its cytotoxicity was measured on four different cancerous cell lines.
Das
Biswanath
B
Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad, India. biswanathdas@yahoo.com
Reddy
Kongara Ravinder
KR
Ravikanth
Bommena
B
Raju
Tuniki Venugopal
TV
Sridhar
Balasubramanian
B
Khan
Patan Usman
PU
Rao
Janapala Venkateswara
JV
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D031286:Jatropha / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; C530347:lathyrane