title: Enantioselective synthesis of homo-N-nucleosides containing a 1,4-dioxane sugar analog.
abstract: A dioxane homo-sugar analog, (2S,5S)-and (2R,5S)-5-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-iodomethyl-1,4-dioxane was prepared from (2R,3R)-dimethyl tartrate, and further elaborated into the corresponding homo-N-nucleoside analogs by its reactions with uracil and adenine, respectively.
authors.affiliation: Department of Chemistry, Norwegian University of Science and Technology (NTNU), N-7491 Trondheim, Norway.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Yu
authors.forename: Per
authors.initials: P
authors.lastname: Carlsen
mesh_terms: D004146:Dioxanes / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D004146:Dioxanes; D009705:Nucleosides; C025223:1,4-dioxane