Rowell's syndrome in the course of treatment with sodium valproate: a case report and review of the literature data.
Rowell's syndrome (RS) is a rare type of coexistence of one of the lupus erythematosus (LE) types (systemic, subacute cutaneous or discoid) and erythema multiforme (EM) (including toxic epidermal necrolysis). We present the case of a 51-year-old patient with a diagnosis of RS, most probably caused by drugs given as psychiatric treatment. After cessation of sodium valproate and initiation of treatment with prednisolone, a spectacular clinical remission was achieved. The likely role of psychiatric drugs, namely sodium valproate and sertraline, as triggering factors, is discussed.
Kacalak-Rzepka
A
A
Department of Dermatology and Venereology, Pomeranian Medical Univeristy, St. Szczecin, Poland. klinderm@sci.pam.szczecin.pl
Kiedrowicz
M
M
Bielecka-Grzela
S
S
Ratajczak-Stefanska
V
V
Maleszka
R
R
Mikulska
D
D
D014150:Antipsychotic Agents / Q000009:adverse effects*; D001569:Benzodiazepines / Q000009:adverse effects; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004359:Drug Therapy, Combination; D004892:Erythema Multiforme / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D008178:Lupus Erythematosus, Cutaneous / Q000139:chemically induced* / Q000473:pathology; D008875:Middle Aged; D000077152:Olanzapine; D010493:Pericarditis / Q000139:chemically induced; D020280:Sertraline / Q000009:adverse effects; D013577:Syndrome; D016896:Treatment Outcome; D014635:Valproic Acid / Q000009:adverse effects*
D014150:Antipsychotic Agents; D001569:Benzodiazepines; D014635:Valproic Acid; D000077152:Olanzapine; D020280:Sertraline