title: Genetic Programming of Conventional Features to Detect Seizure Precursors.
abstract: This paper presents an application of genetic programming (GP) to optimally select and fuse conventional features (C-features) for the detection of epileptic waveforms within intracranial electroencephalogram (IEEG) recordings that precede seizures, known as seizure-precursors. Evidence suggests that seizure-precursors may localize regions important to seizure generation on the IEEG and epilepsy treatment. However, current methods to detect epileptic precursors lack a sound approach to automatically select and combine C-features that best distinguish epileptic events from background, relying on visual review predominantly. This work suggests GP as an optimal alternative to create a single feature after evaluating the performance of a binary detector that uses: 1) genetically programmed features; 2) features selected via GP; 3) forward sequentially selected features; and 4) visually selected features. Results demonstrate that a detector with a genetically programmed feature outperforms the other three approaches, achieving over 78.5% positive predictive value, 83.5% sensitivity, and 93% specificity at the 95% level of confidence.
authors.affiliation: gte851r@mail.gatech.edu , Ph.D. Candidate, Georgia Institute of Technology, Intelligent Control Systems Laboratory, Biomedical Engineering Research Group, 813 Ferst Drive, N.W., Atlanta, GA 30332.
authors.forename: Otis
authors.initials: O
authors.lastname: Smart
authors.forename: Hiram
authors.initials: H
authors.lastname: Firpi
authors.forename: George
authors.initials: G
authors.lastname: Vachtsevanos