title: Triterpenoid saponins from Ardisia pusilla and their cytotoxic activity.
abstract: Three new triterpenoid saponins 3, 4 and 5, together with two known saponins, ardisiacrispin B (1) and ardisiacrispin A (2), were isolated from the whole plants of Ardisia pusilla A. DC. Their structures were elucidated by extensive spectral analysis and chemical evidence. Compound 3 is a hexaglycoside with a 13,28-epoxyoleanane type aglycone, while both 4 and 5 are triterpenoid tetraglycosides related to the olean-12-ene skeleton. Saponins 1-4 exhibited significant cytotoxicity against human glioblastoma U251MG cells, but did not affect the growth of primary cultured human astrocytes.
authors.affiliation: Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, PR China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Tian
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Tang
authors.forename: Feng
authors.initials: F
authors.lastname: Qiu
authors.forename: Xiao-Juan
authors.initials: XJ
authors.lastname: Wang
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Chen
authors.forename: Ai-Dong
authors.initials: AD
authors.lastname: Wen
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D031644:Ardisia / Q000737:chemistry*; D045744:Cell Line, Tumor; D002478:Cells, Cultured; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes