Toxicogenomics and clinical toxicology: an example of the connection between basic and applied sciences.
The relationship between basic research and its potential clinical applications is often a difficult subject. Clinical toxicology has always been very dependent on experimental research whose usefulness has been impaired by the existence of huge differences in the toxicity expression of different substances, inter- and intra-species which make it difficult to predict clinical effects in humans. The new methods in molecular biology developed in the last decades are furnishing very useful tools to study some of the more relevant molecules implied in toxicokinetic and toxicodynamic processes. We aim to show some meaningful examples of how recent research developments with genes and proteins have clear applications to understand significant clinical matters, such as inter-individual variations in susceptibility to chemicals, and other phenomena related to the way some substances act to induce variations in the expression and functionality of these targets.
Ferrer-Dufol
Ana
A
Unit of Clinical Toxicology, Clinic University Hospital. Zaragoza University, San Juan Bosco 15, 50009 Zaragoza, Spain. aferrerd@salud.aragon.es
Menao-Guillen
Sebastian
S
D000818:Animals; D035843:Biomedical Research / Q000379:methods*; D015510:Clinical Medicine / Q000379:methods*; D014644:Genetic Variation; D006801:Humans; D011237:Predictive Value of Tests; D013045:Species Specificity; D043922:Toxicogenetics / Q000379:methods*; D015262:Xenobiotics / Q000493:pharmacokinetics / Q000633:toxicity*
D015262:Xenobiotics