title: Lipoprotein lipase 1595 c/g and hepatic lipase -480 c/t polymorphisms--impact on lipid profile in incident dialysis patients.
abstract: BACKGROUND
  Dyslipidemia is a common complication of chronic kidney disease. Lipoprotein lipase (LPL) 1595 C/G and hepatic lipase (HL) -480 C/T single nucleotide polymorphisms (SNPs) influence lipid profile and predisposition for cardiovascular disease in the general population. The present study was undertaken to clarify the impact of the two polymorphisms on lipid parameters and cardiovascular risk in incident dialysis patients.
  
  
  METHODS
  LPL 1595 C/G and HL -480 C/T SNPs were evaluated in 293 chronic kidney disease patients close to dialysis initiation. Associations with lipid parameters, presence of cardiovascular disease, and survival were assessed.
  
  
  RESULTS
  LPL 1595 C/G SNP was associated with significantly lower triglyceride levels [1.55 (1.00-2.20) vs. 1.90 (1.40-2.48) mM; p < 0.01], while HL -480 C/T polymorphism was associated with increased high density lipoprotein cholesterol concentration [1.30 (1.00-1.60) vs. 1.10 (0.90-1.40) mM; p < 0.05]. Neither of the polymorphisms showed any relationship with patient survival.
  
  
  CONCLUSIONS
  LPL 1595 C/G and HL -480 C/T polymorphisms affect lipid profile in incident dialysis patients.
authors.affiliation: Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Technology and Intervention, Karolinska Institutet, Stockholm, Sweden. chmiel@amg.gda.pl
authors.forename: Michal
authors.initials: M
authors.lastname: Chmielewski
authors.forename: Peter
authors.initials: P
authors.lastname: Stenvinkel
authors.forename: Karin
authors.initials: K
authors.lastname: Luttropp
authors.forename: Mohammed E
authors.initials: ME
authors.lastname: Suliman
authors.forename: Abdul R
authors.initials: AR
authors.lastname: Qureshi
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Carrero
authors.forename: Peter
authors.initials: P
authors.lastname: Barany
authors.forename: Olof
authors.initials: O
authors.lastname: Heimburger
authors.forename: Louise
authors.initials: L
authors.lastname: Nordfors
authors.forename: Bengt
authors.initials: B
authors.lastname: Lindholm
mesh_terms: D008076:Cholesterol, HDL / Q000097:blood; D002908:Chronic Disease; D006801:Humans; D007674:Kidney Diseases / Q000097:blood / Q000235:genetics; D008049:Lipase / Q000235:genetics*; D008055:Lipids / Q000097:blood*; D008071:Lipoprotein Lipase / Q000235:genetics*; D011110:Polymorphism, Genetic; D006435:Renal Dialysis; D015996:Survival Rate; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; C504173:LIPC protein, human; D008055:Lipids; D014280:Triglycerides; D008049:Lipase; D008071:Lipoprotein Lipase