title: Immediate acid-suppressing effects of ranitidine hydrochloride and rabeprazole sodium following initial administration and reintroduction: A randomized, cross-over study using wireless pH monitoring capsules.
abstract: OBJECTIVE
  Histamine 2 receptor antagonists and proton-pump inhibitors, drugs that are widely used for the treatment of acid-related diseases, have different clinical characteristics. The objective of this study was to compare the acid-suppressing effects of ranitidine hydrochloride and those of rabeprazole sodium at the first administration and re-administration after withdrawal.
  
  
  METHODS
  The study was designed as an open-label, randomized, two-way cross-over trial. Seven Helicobacter pylori-negative healthy volunteers were enrolled in this study. Ranitidine hydrochloride (300 mg/day) or rabeprazole sodium (20 mg/day) was administered from days 1 to 7 and from days 11 to 13. The percentage of time with gastric pH < 4 and the median gastric pH were evaluated for 15 consecutive days by a Bravo capsule fixed to the stomach.
  
  
  RESULTS
  On day 1, there was no significant difference between the acid-suppressing effects of the two drugs (ranitidine vs rabeprazole: not significant). Although rabeprazole sodium maintained a potent and stable effect from days 2 to 7 (ranitidine vs rabeprazole: P < 0.05), the effect of ranitidine hydrochloride was attenuated after day 4. In addition, the effect of ranitidine hydrochloride at re-administration was attenuated (days 11, 12, and 13 vs pre-administration: not significant).
  
  
  CONCLUSIONS
  In view of our observations, we expect symptoms associated with gastric acidity to be more adequately controlled with rabeprazole sodium in the short term when compared to ranitidine hydrochloride.
authors.affiliation: Division of Endoscopy, Hokkaido University Hospital, Sapporo, Hokkaido 060-8638, Japan.
authors.forename: Shouko
authors.initials: S
authors.lastname: Ono
authors.forename: Mototsugu
authors.initials: M
authors.lastname: Kato
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ono
authors.forename: Aki
authors.initials: A
authors.lastname: Imai
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yoshida
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Masahiro
authors.initials: M
authors.lastname: Asaka
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000008:administration & dosage*; D000328:Adult; D000897:Anti-Ulcer Agents / Q000008:administration & dosage*; D018592:Cross-Over Studies; D004334:Drug Administration Schedule; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination / Q000295:instrumentation*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D006635:Histamine H2 Antagonists / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D018670:Monitoring, Ambulatory / Q000295:instrumentation; D054328:Proton Pump Inhibitors / Q000008:administration & dosage*; D064750:Rabeprazole; D011899:Ranitidine / Q000008:administration & dosage*; D013686:Telemetry / Q000295:instrumentation; D013997:Time Factors
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents; D006635:Histamine H2 Antagonists; D054328:Proton Pump Inhibitors; D064750:Rabeprazole; D011899:Ranitidine