title: Frequency of the severe combined immunodeficiency disease gene among horses in Morocco.
abstract: Severe combined immunodeficiency disease (SCID) of horses is an autosomal, recessive hereditary disease occurring among Arabian or crossbred Arabian horses. The genetic defect responsible was previously identified as a 5-base pair deletion in the gene encoding the catalytic subunit of the DNA dependant protein kinase (DNA-PKcs). This study was carried out to determine the frequency of SCID and identify horses carrying the gene for SCID among Arabian and Arabian crossbred stallions and mares in Morocco using a DNA-based test. Twenty-one horses were SCID carriers: 14 (7%) Arabians, 6 (4%) Arab-Barbs and one (33%) Anglo-Arab. After analysing their genealogy, 3 imported stallions were identified that disseminated the mutant gene of DNA-PKcs in Morocco.
authors.affiliation: Veterinary Genetics Laboratory, Hassan II Institute of Agronomy and Veterinary Medicine, Department of Medicine Surgery and Animal Breeding, 10101 Rabat, Morocco.
authors.forename: M
authors.initials: M
authors.lastname: Piro
authors.forename: A
authors.initials: A
authors.lastname: Benjouad
authors.forename: N S
authors.initials: NS
authors.lastname: Tligui
authors.forename: K
authors.initials: K
authors.lastname: El Allali
authors.forename: M
authors.initials: M
authors.lastname: El Kohen
authors.forename: A
authors.initials: A
authors.lastname: Nabich
authors.forename: L
authors.initials: L
authors.lastname: Ouragh
mesh_terms: D000818:Animals; D001947:Breeding; D051747:DNA-Activated Protein Kinase; D005260:Female; D005787:Gene Frequency / Q000235:genetics*; D006734:Horse Diseases / Q000175:diagnosis / Q000235:genetics*; D006736:Horses; D008297:Male; D009018:Morocco / Q000453:epidemiology; D016133:Polymerase Chain Reaction / Q000662:veterinary; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D016511:Severe Combined Immunodeficiency / Q000175:diagnosis / Q000235:genetics / Q000662:veterinary*
chemical_list: D051747:DNA-Activated Protein Kinase; D017346:Protein Serine-Threonine Kinases