Pd-catalyzed deoxygenation of mandelate esters.
A new approach to the synthesis of phenylacetic acids and esters has been developed via the palladium-catalyzed deoxygenation of mandelate esters.
Milne
Jacqueline E
JE
Chemical Process R&D, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, USA. milne@amgen.com
Murry
Jerry A
JA
King
Anthony
A
Larsen
Robert D
RD
D002384:Catalysis; D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry*; D008333:Mandelic Acids / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D010648:Phenylacetates / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
D004952:Esters; D008333:Mandelic Acids; D009942:Organometallic Compounds; D010648:Phenylacetates; D010165:Palladium; C025136:phenylacetic acid; C037938:mandelic acid; D010100:Oxygen