Treatment with high-dose methylprednisolone for hepatic veno-occlusive disease in a child with rhabdomyosarcoma.
Hepatic veno-occlusive disease (VOD), also called sinusoidal obstruction syndrome, is rapidly progressing and involves life-threatening complications that can occur in patients receiving chemotherapy and/or bone marrow transplantation. No completely satisfactory treatmentstrategies have yet been established. We present a case of rhabdomyosarcoma ina 21-month-old boy who developed pancytopenia, dyspnea, jaundice, massive ascites and body weight gain of more than 10% after receiving conventional chemotherapy. Hepatic VOD was diagnosed. He recovered after supportive care and treatment with high-dose methylprednisolone.
Chen
I-Lun
IL
Department of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Yang
San-Nan
SN
Hsiao
Chih-Cheng
CC
Wu
Kuan-Sheng
KS
Sheen
Jiunn-Ming
JM
D005938:Glucocorticoids / Q000008:administration & dosage*; D006258:Head and Neck Neoplasms / Q000150:complications*; D006504:Hepatic Veno-Occlusive Disease / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D012208:Rhabdomyosarcoma / Q000150:complications*
D005938:Glucocorticoids; D008775:Methylprednisolone