title: Accelerated bilateral dynamic contrast-enhanced 3D spiral breast MRI using TSENSE.
abstract: OBJECTIVE
  To assess the ability of adaptive sensitivity encoding incorporating temporal filtering (TSENSE) to accelerate bilateral dynamic contrast-enhanced (DCE) 3D breast MRI.
  
  
  METHODS
  Bilateral DCE breast magnetic resonance imaging (MRI) exams were performed using a dual-band water-only excitation and a "stack-of-spirals" imaging trajectory. TSENSE was applied in the slab direction with an acceleration factor of 2. Four different techniques for sensitivity map calculation were compared by analyzing resultant contrast uptake curves qualitatively and quantitatively for 10 patient datasets. In addition, image quality and temporal resolution were compared between unaccelerated and TSENSE images.
  
  
  RESULTS
  TSENSE can increase temporal resolution by a factor of 2 in DCE imaging, providing better depiction of contrast uptake curves and good image quality. Of the different methods tested, calculation of static sensitivity maps by averaging late postcontrast frames yields the lowest aliasing artifact level based on ROI analysis.
  
  
  CONCLUSIONS
  TSENSE acceleration combined with 3D spiral imaging is very time-efficient, providing 11-second temporal resolution and 1.1 x 1.1 x 3 mm(3) spatial resolution over a 20 x 20 x 10 cm(3) field of view for each breast.
authors.affiliation: Lucas MRS/I Center, Department of Radiology, Stanford University, 1201 Welch Rd., Stanford, CA 94305-5488, USA. hanmi@stanford.edu
authors.forename: Misung
authors.initials: M
authors.lastname: Han
authors.forename: Bruce L
authors.initials: BL
authors.lastname: Daniel
authors.forename: Brian A
authors.initials: BA
authors.lastname: Hargreaves
mesh_terms: D016477:Artifacts; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology*; D003287:Contrast Media / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods*; D019047:Phantoms, Imaging
chemical_list: D003287:Contrast Media