title: Telangiectasia macularis eruptiva perstans, a form of cutaneous mastocytosis, associated with malignant melanoma.
abstract: A 62-year-old obese woman presented with a malignant melanoma (Stage la). In addition, she had disseminated telangiectatic macules on both thighs. Intensive rubbing of lesions resulted in wheals. Biopsy revealed increased numbers of mast cells. We diagnosed telangiectasia macularis eruptiva perstans, a rare clinical form of adult maculopapular cutaneous mastocytosis, a group which also includes urticaria pigmentosa. No evidence was found for systemic involvement. Possible associations with malignant tumors and the possible role of c-kit mutations both in development of melanoma and mastocytosis are discussed.
authors.affiliation: Department of Dermatology and Allergy, HELIOS Vogtland Clinic Plauen Ltd., Plauen, Germany. lutz.kowalzick@helioskliniken.de
authors.forename: Lutz
authors.initials: L
authors.lastname: Kowalzic
authors.forename: Lena
authors.initials: L
authors.lastname: Eickenscheidt
authors.forename: Christoph
authors.initials: C
authors.lastname: Seidel
authors.forename: Sabine
authors.initials: S
authors.lastname: Kribus
authors.forename: Heidrun
authors.initials: H
authors.lastname: Ziegler
authors.forename: Michael
authors.initials: M
authors.lastname: Komar
mesh_terms: D005260:Female; D006801:Humans; D034701:Mastocytosis, Cutaneous / Q000150:complications* / Q000473:pathology*; D008545:Melanoma / Q000150:complications* / Q000473:pathology*; D008875:Middle Aged; D012878:Skin Neoplasms / Q000150:complications* / Q000473:pathology*; D013684:Telangiectasis / Q000150:complications* / Q000473:pathology*