title: Reevaluation of solubility of tolbutamide and polymorphic transformation from Form I to unknown crystal form.
abstract: Thermodynamic stability order of tolbutamide between polymorphs was evaluated using calorimetry and spectroscopic analysis. The heat of solution (DeltaH) of Forms I-III measurements were carried out in dimethylsulfoxide between 298.2K and 319.2K. It was found that the DeltaH of Forms II and III was increased nearly parallel with a temperature rise. However, change of the DeltaH of Form I with a temperature rise was not in correspondence with that of other forms. Solubility data confirmed the change in DeltaH of Form I around 308.2K. XRD-DSC measurement of Form I detected a polymorphic transformation (Form I(L)-->unknown form) at 311K. Obtained data suggested that the new crystal form (Form I(H)) would exist above 311K, and the order of thermodynamic stability was "Form III<Form I(L)<Form II" below the transition temperature, on the other hand, the order was changed in "Form I(L) and Form I(H)<Form III<Form II" above the transition temperature. The crystal structure of Form I(H) was determined by measurement of PXRD pattern on BL19B2 at SPring-8, and the change in the solid-state NMR spectrum confirmed the transformation of the crystal structure of Form I(L).
authors.affiliation: Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan.
authors.forename: Gen
authors.initials: G
authors.lastname: Hasegawa
authors.forename: Takao
authors.initials: T
authors.lastname: Komasaka
authors.forename: Rui
authors.initials: R
authors.lastname: Bando
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Yoshihashi
authors.forename: Etsuo
authors.initials: E
authors.lastname: Yonemochi
authors.forename: Kotaro
authors.initials: K
authors.lastname: Fujii
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Uekusa
authors.forename: Katsuhide
authors.initials: K
authors.lastname: Terada
mesh_terms: D002152:Calorimetry, Differential Scanning; D003460:Crystallization; D004355:Drug Stability; D007004:Hypoglycemic Agents / Q000737:chemistry*; D012995:Solubility; D013696:Temperature; D013816:Thermodynamics; D014044:Tolbutamide / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D007004:Hypoglycemic Agents; D014044:Tolbutamide