title: Dental management of patients with a history of bisphosphonate therapy: clinical dilemma.
abstract: Bisphosphonate osteonecrosis, BON, was recently described in the literature. Lack of scientific evidence explaining the pathophysiologic mechanisms involved in the development of this oral complication has generated uncertainties about proper management of patients treated with a bisphosphonate. This manuscript discusses the dental management of two breast cancer patients treated with intravenous bisphosphonates as part of their cancer management and who developed oral disease. Clinical management decisions will be presented as well as the treatment outcomes.
authors.affiliation: Nova Southeastern University, College of Dental Medicine, Fort Lauderdale, Fla 33328, USA.
authors.forename: Cesar A
authors.initials: CA
authors.lastname: Migliorati
authors.forename: Chiu-Jen
authors.initials: CJ
authors.lastname: Hsu
authors.forename: Sonia
authors.initials: S
authors.lastname: Chopra
authors.forename: Steven S
authors.initials: SS
authors.lastname: Kaltman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D050071:Bone Density Conservation Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000150:complications / Q000188:drug therapy*; D017742:Dental Care for Chronically Ill; D004164:Diphosphonates / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007571:Jaw Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D010020:Osteonecrosis / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates