title: [Familial summer-type hypersensitivity pneumonitis in a husband and wife].
abstract: We encountered a family in which two of four members, the husband and his wife, had summer-type hypersensitivity pneumonitis at the same time, about two months after they moved to the residence. A 45-year-old man had cough, fever and exertional dyspnea. Chest computed tomography showed diffuse centriloblar ground-glass attenuation in both lung fields. His 43-year-old wife had chest small nodular shadows and similar symptoms to his husband. Serum anti-Tricosporon cutaneum (T. asahi: serotype II and T. mucoides: serotype I) antibodies of both patients were at the positive level. They were given diagnosis as summer-type hypersensitivity pneumonitis by radiological, serological and histological examinations. The symptoms in both cases were improved immediately after administration of systemic corticosteroid. Summer-type hypersensitivity pneumonitis was assumed to be caused for about two months duration of expousure to antigen.
authors.affiliation: Department of Internal Medicine II, Oita University Faculty of Medicine.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Amemiya
authors.forename: Ryo
authors.initials: R
authors.lastname: Shirai
authors.forename: Syunji
authors.initials: S
authors.lastname: Ando
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Fujii
authors.forename: Atsuko
authors.initials: A
authors.lastname: Iwata
authors.forename: Naoko
authors.initials: N
authors.lastname: Kai
authors.forename: Satoshi
authors.initials: S
authors.lastname: Otani
authors.forename: Kenji
authors.initials: K
authors.lastname: Umeki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishii
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Kadota
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000328:Adult; D000542:Alveolitis, Extrinsic Allergic / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D000908:Antibodies, Fungal / Q000097:blood; D000946:Antigens, Fungal / Q000009:adverse effects; D015415:Biomarkers / Q000097:blood; D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018454:Spouses; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014250:Trichosporon / Q000276:immunology / Q000472:pathogenicity
chemical_list: D000305:Adrenal Cortex Hormones; D000908:Antibodies, Fungal; D000946:Antigens, Fungal; D015415:Biomarkers