[Pulmonary vascular endothelial cell growth and PPARgamma].
PPARgamma is a member of a family of nuclear receptors/ligand-dependent transcription factors, which bind to hormone response elements on target gene promoters. An antiproliferative and proapoptotic action profile of PPARgamma has been described, but little is known about the role of PPARgamma in vascular remodeling. We reported a reduced PPARgamma gene and protein expression in the lungs from patients with severe pulmonary hypertension and loss of PPARgamma expression in their complex vascular lesion. We showed that fluid shear stress reduces PPARgamma expression in ECV304 endothelial cells and that ECV304 cells that stably express dominant-negative PPARgamma form lumen-obliterating lung vascular lesion in the artificial capillaries under fluid shear stress and in the intrapulmonary arteries after tail vein injection in nude mice. Recently, there are some evidences that PPARgamma may represent a novel therapeutic target in pulmonary hypertension.
Ameshima
Shingo
S
Third Department of Internal Medicine, University of Fukui.
D000818:Animals; D049109:Cell Proliferation; D042783:Endothelial Cells / Q000166:cytology*; D006976:Hypertension, Pulmonary / Q000473:pathology; D051379:Mice; D008819:Mice, Nude; D047495:PPAR gamma / Q000502:physiology*; D011651:Pulmonary Artery / Q000166:cytology*
D047495:PPAR gamma