Human chorionic gonadotropin ratio of hemoperitoneum versus venous serum improves early diagnosis of ectopic pregnancy.
OBJECTIVE
To analyze the value of the hCG ratio of peritoneal serum versus venous serum (R(P/V)) for early diagnosis and prognostic evaluation of ectopic pregnancy (EP).


METHODS
Retrospective clinical study.


METHODS
University hospital.


METHODS
One hundred three women with hemoperitoneum and positive urine hCG tests underwent laparoscopy or laparotomy.


METHODS
Venous serum and peritoneal serum samples were obtained; ultrasound was performed in all the patients; dilatation and curettage was used in 28 patients.


METHODS
Quantitative hCG and R(P/V).


RESULTS
The R(P/V) in EP (5.55 +/- 4.32) is apparently greater than that in hemoperitoneum with intrauterine pregnancy (hIUP; 0.61 +/- 0.18). The median R(P/V) is 4.07 in the EP group versus 0.60 in the hIUP group, with a suggested threshold value of 1.0 for their differential diagnosis. Moreover, the R(P/V) of EP shows the dominant difference between the patients with active bleeding (8.03 +/- 3.29, n = 24) and the patients without active bleeding (4.59 +/- 3.88, n = 16) when the hCG level of venous serum is more than 1500 U/L.


CONCLUSIONS
R(P/V) could instantly diagnose ectopic pregnancy and differentiate it from hIUP.
Wang
YuDong
Y
Department of Obstetrics and Gynecology, the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, People's Republic of China.
Zhao
Hong
H
Teng
YinCheng
Y
Lu
LiHua
L
Tong
JianQian
J
D006063:Chorionic Gonadotropin / Q000097:blood*; D003937:Diagnosis, Differential; D042241:Early Diagnosis; D005260:Female; D006465:Hemoperitoneum / Q000175:diagnosis* / Q000378:metabolism*; D006801:Humans; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000097:blood* / Q000175:diagnosis*; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
D006063:Chorionic Gonadotropin