title: Evaluation of cardiac iron overload in transfusion-dependent adult marrow failure patients by magnetic resonance imaging.
abstract: We investigated magnetic resonance imaging T2-star (MRI-T2*) values and left ventricular ejection fraction (LVEF) in 7 adult patients with bone marrow failure with heavy transfusion to elucidate the correlation between cardiac iron overload and dysfunction. We demonstrated a positive correlation between the total volume of red blood cells (RBC) transfusion and ejection fraction. The normal T2* limit value, which represents cardiac siderosis, is probably 200 mL/kg RBC transfusion. Patients with serum ferritin levels of under 5000 ng/mL and who received 200-400 mL/kg RBC transfusion showed mild but progressive decrease of the T2* value without obvious reduction of the ejection fraction, indicating that the T2* value of MRI could be a predictor for cardiac iron deposition before the appearance of myocardial dysfunction. Transfused RBC amount of >400 mL/kg or rapid elevation of ferritin level of >5000 ng/mL might be warning sign for critical cardiac dysfunction. Since iron overload of the heart is a major factor affecting co-morbidity of bone marrow failure, MRI evaluation of cardiac iron overload and functional disturbance in adult non-thalassemic patients is essential.
authors.affiliation: Department of Radiology, Tokyo Medical University, Tokyo, Japan.
authors.forename: Jinho
authors.initials: J
authors.lastname: Park
authors.forename: Kazuma
authors.initials: K
authors.lastname: Ohyashiki
authors.forename: Soichi
authors.initials: S
authors.lastname: Akata
authors.forename: Kenichi
authors.initials: K
authors.lastname: Takara
authors.forename: Ritsuko
authors.initials: R
authors.lastname: Uno
authors.forename: Dai
authors.initials: D
authors.lastname: Kakizaki
authors.forename: Keisuke
authors.initials: K
authors.lastname: Miyazawa
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Kimura
authors.forename: Koichi
authors.initials: K
authors.lastname: Tokuuye
mesh_terms: D000328:Adult; D000368:Aged; D001803:Blood Transfusion; D005260:Female; D006402:Hematologic Diseases / Q000150:complications* / Q000473:pathology / Q000628:therapy; D006801:Humans; D019190:Iron Overload / Q000150:complications* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*