Oxidation of antiparasitic 2-substituted quinolines using metalloporphyrin catalysts: scale-up of a biomimetic reaction for metabolite production of drug candidates.
A study comparing the chemical oxidation of drug candidates with cell-based metabolism (liver microsomes, hepatocytes) shows that biomimetic oxidation can replace the biological approach, thus allowing access to large quantities of metabolites, which can also be used for the preparation of new products.
Akagah
Bernardin
B
Alpha-Chimica, 5 rue Jean-Baptiste Clément, F-92296 Châtenay-Malabry, France.
Lormier
Anh Tuan
AT
Fournet
Alain
A
Figadère
Bruno
B
D000818:Animals; D000977:Antiparasitic Agents / Q000737:chemistry* / Q000378:metabolism; D040761:Biomimetic Materials / Q000737:chemistry* / Q000378:metabolism; D002384:Catalysis; D055808:Drug Discovery; D006801:Humans; D008665:Metalloporphyrins / Q000737:chemistry* / Q000378:metabolism; D010084:Oxidation-Reduction; D011804:Quinolines / Q000737:chemistry* / Q000378:metabolism
D000977:Antiparasitic Agents; D008665:Metalloporphyrins; D011804:Quinolines; C037219:quinoline