Arthritis induced by adjuvant in spontaneously hypertensive and normotensive rats: endogenous glucocorticoid effects on inflammatory response.
The present study investigated arthritis induced by complete Freund adjuvant (AIA) in spontaneously hypertensive and normotensive rats (respectively, SHR and NTR rats). The inflammatory reaction was studied for 28 days by evaluating paw edema and secondary lesions found 10 days after complete Freund adjuvant (CFA) administration. The body weight of the animals and macroscopic alterations of several organs, including spleen, thymus, adrenal glands, and lymph nodes, were also analyzed. The results showed that the AIA manifestations were decreased in SHRs compared with NTRs. Moreover, this altered inflammatory response was not modified by surgical adrenalectomy.
Torres
Micheli G
MG
Laboratory of Inflammation, Department of Pharmacy and Pharmacology, University of Maringá, Maringá, Paraná, Brazil.
Kwasniewski
Fabio H
FH
Scaliante
Luís G
LG
Ishii-Iwamoto
Emy L
EL
Caparroz-Assef
Silvana M
SM
Cuman
Roberto K N
RK
Bersani-Amado
Ciomar A
CA
D000315:Adrenalectomy; D000818:Animals; D001169:Arthritis, Experimental / Q000209:etiology / Q000503:physiopathology*; D001835:Body Weight; D004487:Edema / Q000139:chemically induced / Q000503:physiopathology*; D005620:Freund's Adjuvant; D005938:Glucocorticoids / Q000502:physiology*; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology*; D007249:Inflammation / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D017208:Rats, Wistar; D012016:Reference Values
D005938:Glucocorticoids; D005620:Freund's Adjuvant