Pursuing enigmas on ischemic heart disease and sudden cardiac death.
This article reviews what our colleagues have found as to how ischemic injury or cell death develop in myocardium through Ca(2+)-dependent protease calpain and how compensatory responses evolve through activation of intracellular signaling molecules including PKC isoforms, MAP kinase family enzymes and PI3 kinase. We also addressed how restraint or other psychological stress evokes hypertension and cardiovascular responses in signaling molecules or genes. Unexpectedly, carbon monoxide protects heart and cardiogenic cells against ischemia-resperfusion injury. When I think back, the unresolved cases of autopsies provided ideas for experimental study, which then taught us how the other cases died.
Yoshida
Ken-ichi
K
Department of Forensic Medicine, Graduate School of Medicine and School of Public Health, University of Tokyo, Bunkyo-ku, Tokyo, Japan. kyoshida@m.u-tokyo.ac.jp
D000818:Animals; D017487:Ankyrins / Q000378:metabolism; D002118:Calcium / Q000494:pharmacology; D002154:Calpain / Q000037:antagonists & inhibitors / Q000378:metabolism; D002248:Carbon Monoxide / Q000009:adverse effects; D002352:Carrier Proteins / Q000378:metabolism; D000697:Central Nervous System Stimulants / Q000009:adverse effects; D018031:Connexin 43 / Q000378:metabolism; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D017629:Gap Junctions / Q000502:physiology; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D008694:Methamphetamine / Q000009:adverse effects; D008840:Microfilament Proteins / Q000378:metabolism; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology; D017202:Myocardial Ischemia / Q000378:metabolism* / Q000503:physiopathology*; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control; D009569:Nitric Oxide / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D011493:Protein Kinase C / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D012149:Restraint, Physical / Q000009:adverse effects; D013315:Stress, Psychological / Q000503:physiopathology; D013049:Spectrin
D017487:Ankyrins; D002118:Calcium; D002154:Calpain; D002248:Carbon Monoxide; D002352:Carrier Proteins; D000697:Central Nervous System Stimulants; D018031:Connexin 43; D008694:Methamphetamine; D008840:Microfilament Proteins; D020928:Mitogen-Activated Protein Kinases; D009569:Nitric Oxide; D019869:Phosphatidylinositol 3-Kinases; D011493:Protein Kinase C; D017382:Reactive Oxygen Species; D013049:Spectrin; C500216:GJA1 protein, human