title: Skin and oral lesions associated to imatinib mesylate therapy.
abstract: BACKGROUND
  Imatinib mesylate is a tyrosine kinase inhibitor used to treat chronic myeloid leukemia (CML) throughout all the phases of the disease. In most cases, this drug is well tolerated; however, some cases experience side effects.
  
  
  CONCLUSIONS
  Skin rashes and oral lesions are uncommon and appear to be dose-dependent. The authors report two cases of CML Ph+ in chronic phase patients who presented skin and oral lesions probably induced by imatinib therapy.
authors.affiliation: Hematology and Blood Transfusion Center-University of Campinas, UNICAMP, Campinas, Brazil.
authors.forename: Fernanda Gonçalves
authors.initials: FG
authors.lastname: Basso
authors.forename: Camila Cominato
authors.initials: CC
authors.lastname: Boer
authors.forename: Maria Elvira Pizzigatti
authors.initials: ME
authors.lastname: Corrêa
authors.forename: Marcia
authors.initials: M
authors.lastname: Torrezan
authors.forename: Maria Letícia
authors.initials: ML
authors.lastname: Cintra
authors.forename: Marina H C Gallottini
authors.initials: MH
authors.lastname: de Magalhães
authors.forename: Paulo
authors.initials: P
authors.lastname: da Silva Santos
authors.forename: Cármino Antônio
authors.initials: CA
authors.lastname: de Souza
mesh_terms: D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001549:Benzamides; D004305:Dose-Response Relationship, Drug; D003875:Drug Eruptions / Q000209:etiology; D006801:Humans; D000068877:Imatinib Mesylate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D019226:Oral Ulcer / Q000139:chemically induced* / Q000473:pathology; D010879:Piperazines / Q000008:administration & dosage / Q000009:adverse effects*; D047428:Protein Kinase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects; D011743:Pyrimidines / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D000068877:Imatinib Mesylate