Docking studies suggest ligand-specific delta-opioid receptor conformations.
An automated docking procedure was used to study binding of a series of delta-selective ligands to three models of the delta-opioid receptor. These models are thought to represent the three ligand-specific receptor conformations. Docking results are in agreement with point mutation studies and suggest that different ligands--agonists and antagonists--may bind to the same binding site under different receptor conformations. Docking to different receptor models (conformations) also suggests that by changing to a receptor-specific conformation, the receptor may open or close different binding sites to other ligands.
Micovic
Vuk
V
Institute for General and Physical Chemistry, Belgrade, Serbia.
Ivanovic
Milovan D
MD
Dosen-Micovic
Ljiljana
L
D001665:Binding Sites; D008024:Ligands; D008958:Models, Molecular; D011487:Protein Conformation; D017465:Receptors, Opioid, delta / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000378:metabolism; D013329:Structure-Activity Relationship; D013816:Thermodynamics
D008024:Ligands; D017465:Receptors, Opioid, delta