In vitro comparison of immunological properties of cultured human mesenchymal cells from various sources.
Cell-mediated cytotoxicity was studied in vitro during the interaction of bone marrow mesenchymal stem cells, fibroblast-like cells from newborn umbilical cord, and skin fibroblasts of an adult donor with peripheral blood mononuclear cells. Independently on the origin, mesenchymal cells were not lysed with allogeneic natural killer cells and cytotoxic lymphocytes. Mixed cultures of mesenchymal cells had no cytotoxic effect on peripheral blood mononuclear cells and did not activate proliferation of T and B lymphocytes, natural killer cells, and CD14+ lymphocytes. In vitro experiments showed that mesenchymal cells of different origin and allogeneic immunocompetent cells are tolerant to each other.
Suzdaltseva
Yu G
YG
Russian State Medical University. medcellbox@mail.ru
Burunova
V V
VV
Vakhrushev
I V
IV
Cheglakov
I B
IB
Yarygin
K N
KN
D000328:Adult; D001854:Bone Marrow Cells / Q000166:cytology / Q000276:immunology; D002478:Cells, Cultured; D005347:Fibroblasts / Q000166:cytology / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000276:immunology; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000276:immunology; D012867:Skin / Q000166:cytology; D014470:Umbilical Cord / Q000166:cytology
D006680:HLA Antigens