Effect of antiparkinsonian drug himantane on the content of dopamine transporter DAT protein in rat striatum and cultured pheochromocytoma PC-12 cells.
We studied the effects of antiparkinsonian drug himantane (acute and subchronic administration) on the content of dopamine transporter protein DAT in rat striatum ex vivo and on the content of DTA in cultured PC-12 cells (10(-5) - 10(-7) M, the preparation was added to the incubation medium once or 7 times). The preparation significantly reduced the content of DAT protein both ex vivo and in vitro.
Abaimov
D A
DA
V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow.
Zenina-Antipova
T A
TA
Kovalev
G I
GI
Seredenin
S B
SB
D000218:Adamantane / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000978:Antiparkinson Agents / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism*; D008297:Male; D016716:PC12 Cells / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D000978:Antiparkinson Agents; D050483:Dopamine Plasma Membrane Transport Proteins; C122112:N-(2-adamantyl)hexamethylenimine; D000218:Adamantane