title: Proteinase-activated receptor-2 expression in basal and squamous cell carcinomas compared with normal skin.
abstract: Proteinase-activated receptor-2 (PAR-2) is a transmembrane G-protein expressed in many normal tissues and overexpressed in several cancer cell lines. It contributes to metastasis, promotes epidermal growth factor receptor proliferation, angiogenesis and tumor progression in many carcinomas. The purpose of this study was to investigate the expression of PAR-2 in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) in comparison with that of normal skin. Immunohistochemical (IHC) expression of PAR-2 was examined using paraffin-embedded sections from 30 BCCs, 30 SCCs and also 30 normal sun-exposed skin specimens. PAR-2 was expressed in all specimens of SCC and normal skin. In marked contrast, all BCC specimens had negative IHC staining. Given the important role of PAR-2 in angiogenesis and metastasis, our finding can explain the far less aggressive behavior of BCC as compared with SCC.
authors.affiliation: Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, Iran. dastghl@sums.ac.ir
authors.forename: Ladan
authors.initials: L
authors.lastname: Dastgheib
authors.forename: Ahmad
authors.initials: A
authors.lastname: Monabati
authors.forename: Amanollah
authors.initials: A
authors.lastname: Mohammadian
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Sari-Aslani
authors.forename: Saeed
authors.initials: S
authors.lastname: Marzban
authors.forename: Mohammad R
authors.initials: MR
authors.lastname: Namazi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000378:metabolism* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006258:Head and Neck Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D044464:Receptor, PAR-2 / Q000096:biosynthesis*; D012867:Skin / Q000378:metabolism* / Q000473:pathology; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D044464:Receptor, PAR-2