title: First observation of HIV type 1 drug resistance mutations in Algeria.
abstract: This study demonstrates for the first time HIV-1 resistance mutations to all classes of antiretroviral drugs available in Algeria (NRTIs, NNRTIs, PIs) in treated patients at failure. Moreover, it is shown that mutations to NRTIs and PIs can be observed in untreated patients in this country where there is high HIV-1 diversity.
authors.affiliation: Institut Pasteur, Alger, Algérie.
authors.forename: Salima
authors.initials: S
authors.lastname: Bouzeghoub
authors.forename: Valerie
authors.initials: V
authors.lastname: Jauvin
authors.forename: Patricia
authors.initials: P
authors.lastname: Pinson
authors.forename: Marie Helene
authors.initials: MH
authors.lastname: Schrive
authors.forename: Anne Cecile
authors.initials: AC
authors.lastname: Jeannot
authors.forename: Achour
authors.initials: A
authors.lastname: Amrane
authors.forename: Bernard
authors.initials: B
authors.lastname: Masquelier
authors.forename: El Hadj
authors.initials: el H
authors.lastname: Belabbes
authors.forename: Hervé J
authors.initials: HJ
authors.lastname: Fleury
mesh_terms: D000462:Algeria; D019380:Anti-HIV Agents / Q000494:pharmacology / Q000627:therapeutic use; D024882:Drug Resistance, Viral; D015658:HIV Infections / Q000821:virology*; D016333:HIV Protease / Q000235:genetics; D054303:HIV Reverse Transcriptase / Q000235:genetics; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D020125:Mutation, Missense; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics*; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D017211:Treatment Failure
chemical_list: D019380:Anti-HIV Agents; D012367:RNA, Viral; D054303:HIV Reverse Transcriptase; D016333:HIV Protease; C514803:p16 protease, Human immunodeficiency virus 1