Haemostatic factors in women with history of preeclampsia.
OBJECTIVE
Evaluation of haemostatic parameters--Plasma tissue plasminogen activator (t-PA), plasminogen activator inhibitor type 1 (PAI-1) and fibrin fragment D-dimer several years after the end of pregnancy to investigate if they are modified in women with history of preeclampsia (PE).


METHODS
65 healthy women with history of PE and 54 control women with previous normal pregnancy were enrolled in this study. Groups were matched for age, time period since delivery, smoking status and alcohol consumption. t-PA, PAI-1 and fibrin fragment D-dimer antigen levels were quantified using standards commercial ELISA methods. Plasma fibrinogen was measured using automated capillary zone electrophoresis.


RESULTS
Systolic and diastolic blood pressures were higher in women with history of PE. Levels of t-PA, PAI-1 and fibrinogen were similar between groups as well as the t-PA/PAI-1 ratio. A significant increase in D-dimer levels was observed in women with history of PE.


CONCLUSIONS
The increase in D-dimer level suggests an abnormal haemostatic potential namely increased intravascular coagulation. This, together with the increased blood pressure, can reflect a tendency for an increased risk of cardiovascular/thrombotic events later in life.
Portelinha
Ana
A
Institute for Molecular and Cell Biology, University of Porto, Portugal. aportelinha@gmail.com
Cerdeira
Ana Sofia
AS
Belo
Luís
L
Braga
Jorge
J
Tejera
Eduardo
E
Pinto
Ana
A
Pinto
Fátima
F
Areias
Maria José
MJ
Patrício
Belmiro
B
Rebelo
Irene
I
D000328:Adult; D016022:Case-Control Studies; D019281:Dimerization; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis* / Q000378:metabolism; D005340:Fibrinogen / Q000032:analysis*; D006487:Hemostasis; D006801:Humans; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D010959:Tissue Plasminogen Activator / Q000097:blood*
D005338:Fibrin Fibrinogen Degradation Products; D017395:Plasminogen Activator Inhibitor 1; C036309:fibrin fragment D; D005340:Fibrinogen; D010959:Tissue Plasminogen Activator