Interneurons hyperpolarize pyramidal cells along their entire somatodendritic axis.
Although GABAergic interneurons are the main source of synaptic inhibition in the cortex, activation of GABA(A) receptors has been shown to depolarize specific neuronal compartments, resulting in excitation. By using a noninvasive approach to monitor the effect of individual interneurons on the pyramidal cell population, we found that rat hippocampal interneurons hyperpolarized pyramidal cells irrespective of the location of their synapses along the somato-dendritic axis.
Glickfeld
Lindsey L
LL
Department of Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093-0634, USA.
Roberts
J David
JD
Somogyi
Peter
P
Scanziani
Massimo
M
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D016764:Cell Polarity / Q000502:physiology*; D003712:Dendrites / Q000502:physiology*; D004594:Electrophysiology; D006624:Hippocampus / Q000166:cytology / Q000502:physiology*; D007395:Interneurons / Q000378:metabolism / Q000502:physiology*; D017966:Pyramidal Cells / Q000502:physiology*; D051381:Rats; D011963:Receptors, GABA-A / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid