Change in coronary artery calcification score due to cinacalcet hydrochloride administration.
We examined the influence of cinacalcet on vascular calcification by measuring the coronary artery calcification score (CACS) in hemodialysis patients who received cinacalcet. The cinacalcet treatment group consisted of eight hemodialysis patients with secondary hyperparathyroidism who received cinacalcet for 7-14 months. The mean CACS change in the treatment group was -0.094/year, showing a decreasing tendency, while that in the control group showed an increasing tendency of 0.034/year. The mean CACS change showed a tendency for improvement in the treatment group, but no significant difference from that in the control group was observed as the number of cases was small (P = 0.102). The results of this study suggest that cinacalcet is effective in preventing the progress of extraosseous calcification.
Tsuruta
Yoshinari
Y
Division of Nephrology, Meiyo Clinic Hemodialysis Center, Japan. ytsuruta@meiyokai.or.jp
Ohbayashi
Takaaki
T
Fujii
Mikiko
M
Myochin
Hisashi
H
Mizutani
Ryoko
R
Narita
Masayasu
M
Maeda
Kenji
K
D002114:Calcinosis / Q000188:drug therapy* / Q000209:etiology; D000069449:Cinacalcet; D003324:Coronary Artery Disease; D005500:Follow-Up Studies; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000188:drug therapy* / Q000209:etiology; D007676:Kidney Failure, Chronic / Q000150:complications; D008297:Male; D008875:Middle Aged; D009281:Naphthalenes / Q000494:pharmacology*; D006435:Renal Dialysis; D013997:Time Factors; D016896:Treatment Outcome
D009281:Naphthalenes; D000069449:Cinacalcet