title: No evidence for association between the interferon regulatory factor 1 (IRF1) gene and clinical tuberculosis.
abstract: Interferon regulatory factor 1 is a transcription factor involved in initiating a vigorous Th1 response during Mycobacterium tuberculosis infection. Therefore, we considered it as a possible candidate gene for certain polymorphisms to confer susceptibility to develop clinical tuberculosis. However, all polymorphisms with minor allele frequencies higher than 5% and haplotype frequencies in two Southeast Asian populations (Indonesian and Vietnamese) turned out not to be associated with pulmonary tuberculosis.
authors.affiliation: Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Japan.
authors.forename: Sabine
authors.initials: S
authors.lastname: Vollstedt
authors.forename: Rika
authors.initials: R
authors.lastname: Yuliwulandari
authors.forename: Koji
authors.initials: K
authors.lastname: Okamoto
authors.forename: Luu Thi
authors.initials: LT
authors.lastname: Lien
authors.forename: Naoto
authors.initials: N
authors.lastname: Keicho
authors.forename: Jecti Teguh
authors.initials: JT
authors.lastname: Rochani
authors.forename: Riyani
authors.initials: R
authors.lastname: Wikaningrum
authors.forename: Katsushi
authors.initials: K
authors.lastname: Tokunaga
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D007214:Indonesia; D050856:Interferon Regulatory Factor-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics; D014397:Tuberculosis, Pulmonary / Q000235:genetics*; D014744:Vietnam; D055815:Young Adult
chemical_list: C494257:IRF1 protein, human; D050856:Interferon Regulatory Factor-1