[Characterization of microstructure of ibuprofen-hydroxypropyl-beta-cyclodextrin and ibuprofen-beta-cyclodextrin by atomic force microscope].
The microstructures of ibuprofen-hydroxypropyl-bets-cyclodextrin (IBU-HP-beta-CyD) and ibuprofen-beta-cyclodextrin (IBU-beta-CyD) were observed by atomic force microscope (AFM). The high resolving capability of AFM has the tungsten filament probe with the spring constant of 0.06 N x m(-1). Samples were observed in a small scale scanning area of 10.5 nm x 10.5 nm and 800 x 800 pixels. The original scanning images were gained by tapping mode at room temperature. Their three-dimensional reconstruction of microstructure was performed by G3DR software. The outer diameters of HP-beta-CyD and beta-CyD are 1.53 nm. The benzene diameter of IBU is 0.62 nm, fitting to the inner diameters of HP-beta-CyD and beta-CyD. The benzene and hydrophobic chain of IBU enter into the hole of cyclodextrin at 1:1 ratio. The results were evidenced by IR, X-ray diffraction and the phase solubility.
Wang
Li-juan
LJ
School of Pharmacy, Chongqing University of Medical Sciences, Chongqing 400016, China.
Zhu
Zhao-jing
ZJ
Che
Ke-ke
KK
Ju
Feng-ge
FG
D000073738:2-Hydroxypropyl-beta-cyclodextrin; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000737:chemistry; D016503:Drug Delivery Systems; D007052:Ibuprofen / Q000008:administration & dosage* / Q000737:chemistry; D018625:Microscopy, Atomic Force / Q000379:methods*; D013055:Spectrophotometry, Infrared; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins / Q000737:chemistry*
D018712:Analgesics, Non-Narcotic; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; C031215:betadex; D007052:Ibuprofen