The spliceosome as target for anticancer treatment.
The spliceosome is a ribonucleoprotein complex involved in RNA splicing, that is, the removal of non-coding introns from precursor messenger RNA. (Alternative) Splicing events may play an essential role in tumourigenesis. The recent discovery that the spliceosome is a target for novel compounds with anticancer activity opens up new therapeutic avenues.
van Alphen
R J
RJ
Department of Medical Oncology, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Wiemer
E A C
EA
Burger
H
H
Eskens
F A L M
FA
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D015195:Drug Design; D006801:Humans; D007438:Introns / Q000235:genetics; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D012261:Ribonucleoproteins / Q000235:genetics / Q000378:metabolism; D017381:Spliceosomes / Q000187:drug effects* / Q000378:metabolism
D000970:Antineoplastic Agents; D012261:Ribonucleoproteins