In vive study of dihydroquercetin genotoxicity.
Genotoxic properties of dihydroquercetin were in vivo studied by the method of chromosome aberrations counting and DNA-comet assay. Dihydroquercetin administered repeatedly (5 times, 0.15 and 1.5 mg/kg) or once in doses of 15, 150, and 2000 mg/kg induced no DNA damages in mouse bone marrow, blood, liver, and rectal cells. Single administration of this preparation in doses of 1.5 and 150 mg/kg and 5-fold administration in a dose of 1.5 mg/kg had no effect on the level of chromosome aberrations in mouse bone marrow cells.
Zhanataev
A K
AK
V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow.
Kulakova
A V
AV
Nasonova
V V
VV
Durnev
A D
AD
D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects; D002869:Chromosome Aberrations / Q000139:chemically induced*; D020552:Comet Assay; D004249:DNA Damage; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011794:Quercetin / Q000031:analogs & derivatives* / Q000633:toxicity
D011794:Quercetin; C003377:taxifolin