title: [The combination acetominophen/tramadol in hematological daily practice].
abstract: The combination acetominophen/tramadol implies the use of two molecules which are different in the pharmacological structure but share a biological similarity in kinetics. Their respective actions are directed to different components of the nociceptive afference. Hematological clinical practice daily challenges diseases in with pain may be a very important symptom, ranging from acute leukemia to the common effects of certain chemotherapy regimens. Multiple myeloma gives one of the best example of a disease in which pain can be inflammatory (the compression of a nerve root) or neuropathic (demyelinating process) in origin. The use of acetaminophen/tramadol combination in the common ward or outward activity with myeloma patients indicates how it is possible to reach a good control of chronic pain with a minimum overlapping of the toxicities related to the primary disease as well as to the specific treatment. Furthermore, acetaminophen/tramadol combination is extremely useful also in those clinical situations in which a short term pain control is needed, particularly for the optimal safety profile.
authors.affiliation: Sezione di Ematologia, Dipartimento di Scienze Biomediche e Terapie Avanzate, Azienda Ospedaliera-Universitaria Arcispedale S. Anna, Ferrara, Italy. cvzfnc@unife.it
authors.forename: F
authors.initials: F
authors.lastname: Cavazzini
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use*; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use*; D044963:Biopsy, Fine-Needle / Q000009:adverse effects; D001853:Bone Marrow / Q000473:pathology; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D014147:Tramadol / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen; D014147:Tramadol