The effect of human mesenchymal stem cells on tumour cell proliferation.
The therapeutic effect of mesenchymal stem cells (MSC) has been extensively investigated in recent decades, however this therapeutic effect has not been fully characterised. The aim of this study is to elucidate the inhibitory effect of MSC on haematopoietic tumour cells proliferation such as BV173 cell line. To this end, MSC generated from bone marrow, after immunophenotyping, they were co-cultured with tumour cell. The result shows that MSC profoundly inhibit the tumour cell proliferation via arresting the tumour cells at G0 and G1 phase of cell cycle.
Sarmadi
V H
VH
Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra, Malaysia.
Heng
F S
FS
Ramasamy
R
R
D002453:Cell Cycle / Q000187:drug effects*; D002454:Cell Differentiation; D049109:Cell Proliferation / Q000187:drug effects*; D005434:Flow Cytometry; D006412:Hematopoietic Stem Cells; D006801:Humans; D016130:Immunophenotyping; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology*