Novel calcium silicate/calcium phosphate composites for potential applications as injectable bone cements.
Novel bone cements were developed by using a mixture of calcium silicate and calcium phosphate powder as the solid phase, and a solution of chitosan, sodium phosphate and methylcellulose as the liquid phase. Some characteristics and main parameters of the cements, such as setting time, rheological characteristics and morphology of the composites, were investigated. Range of the setting times is from 10 min to 18 min, which indicates that they are easy to operate in practical applications. As incubated in simulated body fluid, they were degradable and led to the formation of hydroxyapatite. Rheological results further suggest that the composites are injectable.
Li
J
J
Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan 430074, People's Republic of China.
Qiu
Z Y
ZY
Zhou
L
L
Lin
T
T
Wan
Y
Y
Wang
S Q
SQ
Zhang
S M
SM
D001672:Biocompatible Materials; D001826:Body Fluids; D001843:Bone Cements / Q000737:chemistry*; D017610:Calcium Compounds / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008747:Methylcellulose / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D010710:Phosphates / Q000737:chemistry; D016062:Porosity; D012212:Rheology / Q000379:methods; D017640:Silicates / Q000737:chemistry*; D013314:Stress, Mechanical; D013997:Time Factors
D001672:Biocompatible Materials; D001843:Bone Cements; D017610:Calcium Compounds; D002130:Calcium Phosphates; D010710:Phosphates; D017640:Silicates; D008747:Methylcellulose; D048271:Chitosan; C020243:calcium phosphate; C031293:calcium silicate; C018279:sodium phosphate