Pleomorphic adenoma of salivary glands does not appear to be a BRCA-1-dependent tumour in a Polish cohort.
BACKGROUND
The aim of the study was to examine whether pleomorphic adenoma of salivary glands can occur on the basis of constitutional BRCA-1 mutations.


METHODS
Two hundred and sixty-eight patients affected by mixed tumour of salivary glands were examined for occurrence of three BRCA-1 mutations dominating in Poland.


RESULTS
BRCA-1 mutation was detected in only one of the patients, a female affected by breast cancer and pleomorphic adenoma of parotid gland. Parotid gland tumour showed clinical and histopathological features of typical pleomorphic adenoma with no morphological features of high-grade malignancy, which are characteristic of BRCA-1-dependent tumours.


CONCLUSIONS
Considering the low frequency of BRCA-1 mutation in the examined group and also the absence of features characterizing BRCA-1-dependent tumours in the only BRCA-1-positive case, pleomorphic adenoma of salivary glands should not be recognized as a BRCA-1 dependent tumour.
Lubiński
Jakub
J
Department of Otolaryngology with Laryngological Oncology, Pomeranian Medical University, Szczecin, Poland. jakublubinski@o2.pl
Tarnowska
Czesława
C
Jaworowska
Ewa
E
Byrski
Tomasz
T
Jakubowska
Anna
A
Górski
Bogdan
B
Bień
Stanisław
S
Sygut
Jacek
J
Góźdź
Stanisław
S
Siołek
Monika
M
Sulikowski
Mieczysław
M
Lubiński
Jan
J
D008949:Adenoma, Pleomorphic / Q000235:genetics*; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D019398:Genes, BRCA1; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D012468:Salivary Gland Neoplasms / Q000235:genetics*