title: Docking studies suggest ligand-specific delta-opioid receptor conformations.
abstract: An automated docking procedure was used to study binding of a series of delta-selective ligands to three models of the delta-opioid receptor. These models are thought to represent the three ligand-specific receptor conformations. Docking results are in agreement with point mutation studies and suggest that different ligands--agonists and antagonists--may bind to the same binding site under different receptor conformations. Docking to different receptor models (conformations) also suggests that by changing to a receptor-specific conformation, the receptor may open or close different binding sites to other ligands.
authors.affiliation: Institute for General and Physical Chemistry, Belgrade, Serbia.
authors.forename: Vuk
authors.initials: V
authors.lastname: Micovic
authors.forename: Milovan D
authors.initials: MD
authors.lastname: Ivanovic
authors.forename: Ljiljana
authors.initials: L
authors.lastname: Dosen-Micovic
mesh_terms: D001665:Binding Sites; D008024:Ligands; D008958:Models, Molecular; D011487:Protein Conformation; D017465:Receptors, Opioid, delta / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000378:metabolism; D013329:Structure-Activity Relationship; D013816:Thermodynamics
chemical_list: D008024:Ligands; D017465:Receptors, Opioid, delta