title: A new antiangiogenic C24 oxylipin from the soft coral Sinularia numerosa.
abstract: A new oxylipin, 15-hydroxy-tetracosa-6,9,12,16,18-pentaenoic acid (15-HTPE; 1) was isolated as an inhibitor of tube-formation from the soft coral Sinularia numerosa. Its structure was elucidated by means of spectral analysis and chemical degradation. 15-HTPE inhibited tube formation of EA.hy926 cells at the concentration of 20-40 microM.
authors.affiliation: Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Yamashita
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Nakao
authors.forename: Shigeki
authors.initials: S
authors.lastname: Matsunaga
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Oikawa
authors.forename: Yukimitsu
authors.initials: Y
authors.lastname: Imahara
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Fusetani
mesh_terms: D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D054883:Oxylipins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D020533:Angiogenesis Inhibitors; D054883:Oxylipins