title: Toxic effect of an antitumor drug paclitaxel on morphofunctional characteristics of the liver in rats.
abstract: Single intravenous injection of paclitaxel to rats in a maximum tolerated dose of 4.6 mg/kg was accompanied by permanent structural and functional changes in the liver. The observed changes were typical of nonspecific reactive hepatitis: infiltration with lymphocytes and macrophages, pyknosis, and focal fatty degeneration of hepatocytes. Liver enzyme activity increased in blood plasma.
authors.affiliation: Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
authors.forename: L A
authors.initials: LA
authors.lastname: Ermolaeva
authors.forename: T Yu
authors.initials: TY
authors.lastname: Dubskaya
authors.forename: T I
authors.initials: TI
authors.lastname: Fomina
authors.forename: T V
authors.initials: TV
authors.lastname: Vetoshkina
authors.forename: V E
authors.initials: VE
authors.lastname: Gol'dberg
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000633:toxicity*; D015415:Biomarkers / Q000097:blood; D005260:Female; D022781:Hepatocytes / Q000166:cytology / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology*; D017239:Paclitaxel / Q000633:toxicity*; D051381:Rats
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D015415:Biomarkers; D017239:Paclitaxel