title: Phase 2 protein inducers in the diet promote healthier aging.
abstract: Oxidative stress drives many aging-associated problems. Because oxidative stress can be decreased by induction of phase 2 proteins, we hypothesized that incorporating the phase 2 protein inducer 2(3)-tert-butyl-4-hydroxyanisole (tBHA) into the diet would result in healthier aging. C57BL/6 mice were placed either on control mouse chow diet or on chow containing tBHA and were examined at 6, 12, and 18 months. Dietary tBHA resulted in the antioxidant response activation, decreased both oxidative stress and pro-inflammatory gene expression in tissues examined, counteracted the decrease in the transcription factors peroxisome proliferator-activated receptor-gamma and increase in CCAAT/enhancer binding protein-alpha levels seen in liver with aging, and was associated with mice having less weight gain, despite having no differences in food consumption, and better locomotor function. We conclude that simple changes in the diet such as incorporation of phase 2 protein inducers can have a profound influence on health and, thereby, the aging process.
authors.affiliation: Department of Anatomy & Cell Biology, College of Medicine, University of Saskatchewan, Saskatoon, Canada.
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Noyan-Ashraf
authors.forename: Zahra
authors.initials: Z
authors.lastname: Sadeghinejad
authors.forename: Gerald F
authors.initials: GF
authors.lastname: Davies
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Ross
authors.forename: Deborah
authors.initials: D
authors.lastname: Saucier
authors.forename: Troy A A
authors.initials: TA
authors.lastname: Harkness
authors.forename: Bernhard H J
authors.initials: BH
authors.lastname: Juurlink
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D015153:Blotting, Western; D002083:Butylated Hydroxyanisole / Q000494:pharmacology*; D005503:Food Additives / Q000494:pharmacology; D007150:Immunohistochemistry; D007249:Inflammation; D008099:Liver / Q000473:pathology; D013058:Mass Spectrometry; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects; D018384:Oxidative Stress; D013116:Spinal Cord / Q000473:pathology; D014157:Transcription Factors / Q000032:analysis; D015430:Weight Gain / Q000187:drug effects
chemical_list: D000975:Antioxidants; D005503:Food Additives; D014157:Transcription Factors; D002083:Butylated Hydroxyanisole