New dogs in the dogma: Lrp4 and Tid1 in neuromuscular synapse formation.
Two recent papers reported identification of a long-sought agrin coreceptor, Lrp4 (Kim et al. in Cell and Zhang et al. in Neuron). In this issue of Neuron, Linnoila et al. report the identification of a new player in the agrin-MuSK pathway, Tid1, which directly interacts with MuSK and is responsible for transducing signals from MuSK activation to AChR clustering, culminating in cross-linking to the subsynaptic cytoskeleton. These papers substantially reshape the agrin-MuSK-ACh hypothesis of neuromuscular synaptogenesis.
Song
Yuanquan
Y
Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6074, USA.
Balice-Gordon
Rita
R
D018171:Agrin / Q000378:metabolism*; D000818:Animals; D050956:HSP40 Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D026502:LDL-Receptor Related Proteins; D051379:Mice; D009469:Neuromuscular Junction / Q000196:embryology* / Q000378:metabolism* / Q000648:ultrastructure; D011940:Receptor Aggregation / Q000502:physiology; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D011950:Receptors, Cholinergic / Q000378:metabolism; D011973:Receptors, LDL / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D013569:Synapses / Q000378:metabolism* / Q000648:ultrastructure
D018171:Agrin; C485636:Dnaja3 protein, mouse; D050956:HSP40 Heat-Shock Proteins; D026502:LDL-Receptor Related Proteins; C116415:Lrp4 protein, mouse; D011950:Receptors, Cholinergic; D011973:Receptors, LDL; C511695:MuSK protein, mouse; D020794:Receptor Protein-Tyrosine Kinases