title: Study of cholesterol-lowering effect and safety of simvaglisin on rabbit model of hypercholesterolemia.
abstract: Using rabbit model of experimental hypercholesterolemia we showed that the hypocholesterolemic effect of simvaglisin, a complex preparation containing simvastatin and glycyrrhizic acid, in doses corresponding to 40, 66.5, and 100 mg/kg/day simvastatin is equal to the hypocholesterolemic effect of 200 mg/kg/day simvastatin alone. The total blood cholesterol decreased by 39, 36, 47, and 38% (p < 0.05), respectively, after 20-day course of the preparation. Myotoxicity of simvaglisin evaluated by serum creatine phosphokinase was lower than that of simvastatin. After 30-day treatment, this parameter was lower by 26, 24, and 29% (p < 0.05) than the corresponding parameter for simvastatin.
authors.affiliation: N. N. Vorozhtsov Institute of Organic Chemistry, Siberian Division of Russian Academy of Sciences. ragino@online.nsk.su
authors.forename: Y I
authors.initials: YI
authors.lastname: Ragino
authors.forename: V A
authors.initials: VA
authors.lastname: Vavilin
authors.forename: N F
authors.initials: NF
authors.lastname: Salakhutdinov
authors.forename: S I
authors.initials: SI
authors.lastname: Makarova
authors.forename: E M
authors.initials: EM
authors.lastname: Stakhneva
authors.forename: O G
authors.initials: OG
authors.lastname: Safronova
authors.forename: Y P
authors.initials: YP
authors.lastname: Nikitin
authors.forename: G A
authors.initials: GA
authors.lastname: Tolstikov
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D004195:Disease Models, Animal; D019695:Glycyrrhizic Acid / Q000627:therapeutic use*; D006937:Hypercholesterolemia / Q000188:drug therapy*; D008297:Male; D011817:Rabbits; D019821:Simvastatin / Q000627:therapeutic use*
chemical_list: D000924:Anticholesteremic Agents; C531004:simvaglyzin; D019695:Glycyrrhizic Acid; D002784:Cholesterol; D019821:Simvastatin; D003402:Creatine Kinase