Simultaneous determination of ethylenediamine-N,N,N',N'-tetrakismethylene phosphonate and ascorbic acid in "cold" radiopharmaceutical kit.
Ethylenediamine-N,N,N',N'-tetrakismethylene phosphonate (EDTMP) and ascorbic acid (AA) were determined in two batches of lyophilized experimental radiopharmaceutical kits by using ion chromatography with UV detection. The separation of EDTM and AA was carried out on PRP-X 800 weak cation exchange column and as an eluant 0.0025 mol L(-1) sodium sulfate was used. Validation parameters of both analytical procedures: limit of detection (LOD), limit of quantitation (LOQ), linearity, precision, accuracy and system suitability test (SST) parameters are presented.
Lipka
Robert
R
Institute of Atomic Energy, Radioisotope Centre POLATOM, 05-400 Otwock-Swierk, Poland. r.lipka@polatom.pl
Jakubowska
Elzbieta
E
D001205:Ascorbic Acid / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D005029:Ethylenediamines / Q000032:analysis*; D063065:Organophosphonates / Q000032:analysis*; D019275:Radiopharmaceuticals / Q000032:analysis*; D011933:Reagent Kits, Diagnostic; D013056:Spectrophotometry, Ultraviolet
D005029:Ethylenediamines; D063065:Organophosphonates; D019275:Radiopharmaceuticals; D011933:Reagent Kits, Diagnostic; C418473:ethylenediaminetetrakis(methylphosphonic) acid; D001205:Ascorbic Acid