Metabolites from the endophytic mitosporic Dothideomycete sp. LRUB20.
The endophytic mitosporic Dothideomycete sp. LRUB20 was found to produce pyrone derivatives, dothideopyrones A-D (1, 3, 4, and 5), together with seven known compounds, including questin (9), asterric acid (10), methyl asterrate (11), sulochrin (12), and eugenitin (13), 6-hydroxymethyleugenitin (14), and cis, trans-muconic acid (15). Dothideopyrone D (5) and its acetate derivative 6 exhibited moderate cytotoxic activity. This is the first report on a naturally occurring muconic acid, which is commonly known as a biomarker in environments after exposure to benzene and phenol (or derivatives). Interestingly, the LRUB20 fungus could produce muconic acid in relatively high yield (47.8mg/L). The utility of endophytic fungi in the field of white biotechnology is discussed.
Chomcheon
Porntep
P
Chulabhorn Research Institute and Chulabhorn Graduate Institute, Vipavadee-Rangsit Highway, Bangkok 10210, Thailand.
Wiyakrutta
Suthep
S
Sriubolmas
Nongluksna
N
Ngamrojanavanich
Nattaya
N
Mahidol
Chulabhorn
C
Ruchirawat
Somsak
S
Kittakoop
Prasat
P
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D003904:Mitosporic Fungi / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure; D011753:Pyrones / Q000737:chemistry / Q000378:metabolism*
D000970:Antineoplastic Agents; D011753:Pyrones