Ribosome's mode of function: myths, facts and recent results.
Ribosomes translate the genetic code into proteins in all living cells with extremely high efficiency, owing to their inherent flexibility and to their spectacular architecture. During the last 6 decades, extensive effort has been made to elucidate the molecular mechanisms associated with their function, and a quantum jump has been made in recent years, once the three dimensional structures of ribosomes and their functional complexes have been determined. These illuminated key issues in ribosome function, confirmed various biochemical, genetic, and medical findings, and revealed mechanistic details beyond previous expectation, thus leading to conceptual revolutions, and turning old myths into actual facts.
Wekselman
Itai
I
Weizmann Inst of Science, Rehovot, 76100, Israel.
Davidovich
Chen
C
Agmon
Ilana
I
Zimmerman
Ella
E
Rozenberg
Haim
H
Bashan
Anat
A
Berisio
Rita
R
Yonath
Ada
A
D000818:Animals; D001665:Binding Sites; D006801:Humans; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry / Q000378:metabolism; D011487:Protein Conformation; D012269:Ribosomal Proteins / Q000737:chemistry / Q000378:metabolism; D012270:Ribosomes / Q000737:chemistry / Q000378:metabolism*
D010455:Peptides; D012269:Ribosomal Proteins