title: Aging: a sirtuin shake-up?
abstract: The yeast sirtuin (Sir2) is a histone deacetylase that modulates yeast replicative life span by suppressing genome instability through chromatin modification. In this issue, Oberdoerffer et al. (2008) report that SIRT1, the mammalian ortholog of Sir2, is involved in DNA damage-induced chromatin reorganization, which promotes genome stability in mammalian cells.
authors.affiliation: Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA. jvijg@aecom.yu.edu
authors.forename: Jan
authors.initials: J
authors.lastname: Vijg
authors.forename: Alexander Y
authors.initials: AY
authors.lastname: Maslov
authors.forename: Yousin
authors.initials: Y
authors.lastname: Suh
mesh_terms: D000375:Aging / Q000235:genetics*; D000818:Animals; D004260:DNA Repair; D042822:Genomic Instability; D037761:Sirtuins / Q000235:genetics*; D015003:Yeasts
chemical_list: D037761:Sirtuins