title: Role of P2X receptors in positive inotropic effect of rat myocardium during ontogeny.
abstract: Experiments with selective agonists and antagonists of purinoceptors allowed us to evaluate the subtype of P2X receptors. We showed that the myocardium of 14- 100-day-old rats contains functionally active P2X1 receptors. These receptors are involved in the realization of the positive inotropic effect of the atria and ventricles. Selective P2X1 receptor agonist beta,gamma-methylene-ATP induced a dose-dependent increase in the strength of atrial and ventricular contractions. P2X1 receptor antagonist TNP-ATP abolished the effect of the agonist in rats of all age groups.
authors.affiliation: Department of Anatomy, Physiology, and Human Health Protection, Tatar State Humanitarian Pedagogical University, Kazan. alekcei5@rambler.ru
authors.forename: A A
authors.initials: AA
authors.lastname: Zverev
authors.forename: T A
authors.initials: TA
authors.lastname: Anikina
authors.forename: F G
authors.initials: FG
authors.lastname: Sitdicov
mesh_terms: D000255:Adenosine Triphosphate / Q000031:analogs & derivatives / Q000378:metabolism; D000375:Aging / Q000502:physiology*; D000818:Animals; D006321:Heart / Q000033:anatomy & histology / Q000254:growth & development*; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism*; D058910:Purinergic P2 Receptor Agonists; D058919:Purinergic P2 Receptor Antagonists; D051381:Rats; D018048:Receptors, Purinergic P2 / Q000378:metabolism*; D058469:Receptors, Purinergic P2X
chemical_list: D058910:Purinergic P2 Receptor Agonists; D058919:Purinergic P2 Receptor Antagonists; D018048:Receptors, Purinergic P2; D058469:Receptors, Purinergic P2X; C005147:5'-adenylyl (beta,gamma-methylene)diphosphonate; C045674:2',3'-O-(2,4,6-trinitro-cyclohexadienylidine)adenosine 5'-triphosphate; D000255:Adenosine Triphosphate