Beyond HPV: oncomirs as new players in cervical cancer.
MicroRNAs (miRNAs) are a recently discovered family of 18-24 nucleotide non-coding RNAs that can negatively regulate target mRNAs. All studied multicellular eukaryotes utilize miRNAs to regulate basic cellular functions including proliferation, differentiation, and death. It is now apparent that abnormal miRNA expression is a common feature of human malignancies. This review discusses the various cancer-relevant miRNAs (oncomirs) especially in cervical tumorigenesis and the potential role of oncomirs as therapeutic agents and targets for the treatment of cervical cancer.
Reshmi
G
G
Translational Cancer Research Laboratory, Rajiv Gandhi Center for Biotechnology, Thycaud P.O., Thiruvananthapuram 695 014, Kerala, India. reshmi@rgcb.res.in
Pillai
M Radhakrishna
MR
D002277:Carcinoma / Q000188:drug therapy / Q000235:genetics* / Q000628:therapy; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000145:classification / Q000187:drug effects / Q000378:metabolism*; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000628:therapy
D035683:MicroRNAs