title: Effects of Salvia miltiorrhiza on intercellular adhesion molecule 1 protein expression in the lungs of rats with severe acute pancreatitis or obstructive jaundice.
abstract: OBJECTIVE
  The objective of the study was to observe the effects of Salvia miltiorrhiza on intercellular adhesion molecule 1 (ICAM-1) protein expression in the lungs of rats with severe acute pancreatitis (SAP) or obstructive jaundice (OJ).
  
  
  METHODS
  A total of 288 rats were used for SAP- and OJ-associated experiments. The rats were randomly divided into sham-operated, model control, and treated group. According to the difference of time points after operation, the SAP rats of each group were subdivided into 3-, 6-, and 12-hour groups, whereas the OJ rats were divided into 7-, 14-, 21-, and 28-day groups. The contents of interleukin (IL) 6, IL-18, nitric oxide, malondialdehyde, and superoxide dismutase in serum were determined, and pathological changes and ICAM-1 protein expression in the lungs were observed.
  
  
  RESULTS
  Compared with the respective model control groups, in treated groups of SAP and OJ rats, the numbers of dead rats declined; serum superoxide dismutase content significantly increased, and serum IL-18, IL-6, and malondialdehyde contents were significantly decreased; the positive staining intensity of ICAM-1 protein in the lungs decreased significantly (P < 0.05, P < 0.01, or P < 0.001); and pathological changes in the lungs were relieved.
  
  
  CONCLUSIONS
  Salvia miltiorrhiza plays a positive role in the protection of the lungs of SAP and OJ rats.
authors.affiliation: Department of General Surgery, Hangzhou First People's Hospital, Hangzhou, Zhejiang Province, China. zxp99688@vip.163.com
authors.forename: Zhang
authors.initials: Z
authors.lastname: Xiping
authors.forename: Cai
authors.initials: C
authors.lastname: Yang
authors.forename: Wu
authors.initials: W
authors.lastname: Dijiong
authors.forename: Zhang
authors.initials: Z
authors.lastname: Jie
authors.forename: Ye
authors.initials: Y
authors.lastname: Qian
authors.forename: Jiang
authors.initials: J
authors.lastname: Xinge
authors.forename: Ma
authors.initials: M
authors.lastname: Meili
authors.forename: Yang
authors.initials: Y
authors.lastname: Qijun
authors.forename: Xie
authors.initials: X
authors.lastname: Qi
authors.forename: Zhou
authors.initials: Z
authors.lastname: Yifeng
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wenqin
authors.forename: Zhou
authors.initials: Z
authors.lastname: Ningning
authors.forename: He
authors.initials: H
authors.lastname: Jiao
mesh_terms: D000208:Acute Disease; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D041781:Jaundice, Obstructive / Q000188:drug therapy* / Q000401:mortality; D008168:Lung / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D008315:Malondialdehyde / Q000097:blood; D009569:Nitric Oxide / Q000097:blood; D010182:Pancreatic Diseases / Q000401:mortality / Q000517:prevention & control; D010195:Pancreatitis / Q000188:drug therapy* / Q000401:mortality; D028321:Plant Preparations / Q000494:pharmacology*; D011014:Pneumonia / Q000276:immunology / Q000401:mortality / Q000517:prevention & control*; D051381:Rats; D027561:Salvia miltiorrhiza; D012720:Severity of Illness Index; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D004365:Drugs, Chinese Herbal; D015850:Interleukin-6; D016209:Interleukin-8; D028321:Plant Preparations; D018799:Intercellular Adhesion Molecule-1; D009569:Nitric Oxide; D008315:Malondialdehyde; D013482:Superoxide Dismutase