Decreased intrathecal synthesis of prostaglandin D2 synthase in the cerebrospinal fluid of patients with acute inflammatory demyelinating polyneuropathy.
Prostaglandin D(2) synthase (PGDS) is the most abundant brain protein in cerebrospinal fluid (CSF) and is tied closely with inflammatory processes. This study investigated whether CSF PGDS levels in patients with acute inflammatory demyelinating polyneuropathy (AIDP) are altered. The results suggest that PGDS concentration is significantly increased in the CSF of AIDP patients compared with the control patients (p<0.05) due to a blood-CSF barrier dysfunction, whereas the intrathecal synthesis of PGDS, reflected by the CSF PGDS/albumin ratio, is significantly decreased in AIDP compared with the control group (p<0.05). The changes of CSF PGDS/albumin ratio are only observed in AIDP patients, but not in Miller Fisher Syndrome (MFS), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), or multiple sclerosis (MS) patients.
Huang
Yen-Chu
YC
Department of Neurology, Chang Gung Memorial Hospital, Chang-Gung University College of Medicine, Taipei, Taiwan.
Lyu
Rong-Kuo
RK
Tseng
Mu-Yun
MY
Chang
Hong-Shiu
HS
Hsu
Wen-Chuin
WC
Kuo
Hung-Chou
HC
Chu
Chun-Che
CC
Wu
Yih-Ru
YR
Ro
Long-Sun
LS
Huang
Chin-Chang
CC
Chen
Chiung-Mei
CM
D000328:Adult; D000418:Albumins / Q000134:cerebrospinal fluid; D015153:Blotting, Western; D005260:Female; D020275:Guillain-Barre Syndrome / Q000134:cerebrospinal fluid*; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000096:biosynthesis / Q000134:cerebrospinal fluid* / Q000235:genetics; D016014:Linear Models; D054834:Lipocalins / Q000096:biosynthesis / Q000134:cerebrospinal fluid* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D019846:Miller Fisher Syndrome / Q000134:cerebrospinal fluid; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000134:cerebrospinal fluid
D000418:Albumins; D054834:Lipocalins; D019746:Intramolecular Oxidoreductases; C022466:prostaglandin R2 D-isomerase