title: Primary and overall success rates for clinical outcomes after laparoscopic, endoscopic, and open pancreatic cystgastrostomy for pancreatic pseudocysts.
abstract: BACKGROUND
  Internal drainage of pancreatic pseudocysts can be accomplished by traditional open or minimally invasive laparoscopic or endoscopic approaches. This study aimed to evaluate the primary and overall success rates and clinical outcomes after laparoscopic, endoscopic, and open pancreatic cystgastrostomy for pancreatic pseudocysts.
  
  
  METHODS
  Records of 83 patients undergoing laparoscopic (n = 16), endoscopic (n = 45), and open (n = 22) pancreatic cystgastrostomy were analyzed on an intention-to-treat basis.
  
  
  RESULTS
  There were no significant differences (p < 0.05) in the mean patient age (years), gender, body mass index (BMI) (kg/m(2)), etiology of pancreatitis (% gallstone), or size (cm) of pancreatic pseudocyst between the groups. Grade 2 or greater complications occurred within 30 days of the primary procedure for 31.5% of the laparoscopic patients, 15.6% of the endoscopic patients, and 22.7% of the open patients (nonsignificant differences). The follow-up evaluation for 75 patients (90.4%) was performed at a mean interval of 9.5 months (range, 1-40 months). The primary compared with the overall success rate, defined as cyst resolution, was 51.1% vs. 84.6% for the endoscopic group, 87.5% vs. 93.8% for the laparoscopic group, and 81.2% vs. 90.9% for the open group. The primary success rate was significantly higher (p < 0.01) for laparoscopic and open groups than for the endoscopic group, but the overall success rate was equivalent across the groups (nonsignificant differences). Primary endoscopic failures were salvaged by open pancreatic cystgastrostomy (n = 13), percutaneous drainage (n = 3), and repeat endoscopic drainage (n = 6).
  
  
  CONCLUSIONS
  Laparoscopic and open pancreatic cystgastrostomy both have a higher primary success rate than endoscopic internal drainage, although repeat endoscopic cystgastrostomy provides overall success for selected patients.
authors.affiliation: Department of Surgery, Section of Minimally Invasive Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box #8109, St. Louis, MO 63110, USA.
authors.forename: Lora
authors.initials: L
authors.lastname: Melman
authors.forename: Riad
authors.initials: R
authors.lastname: Azar
authors.forename: Kathleen
authors.initials: K
authors.lastname: Beddow
authors.forename: L Michael
authors.initials: LM
authors.lastname: Brunt
authors.forename: Valerie J
authors.initials: VJ
authors.lastname: Halpin
authors.forename: J Christopher
authors.initials: JC
authors.lastname: Eagon
authors.forename: Margaret M
authors.initials: MM
authors.lastname: Frisella
authors.forename: Steven
authors.initials: S
authors.lastname: Edmundowicz
authors.forename: Sreenivasa
authors.initials: S
authors.lastname: Jonnalagadda
authors.forename: Brent D
authors.initials: BD
authors.lastname: Matthews
mesh_terms: D000328:Adult; D015331:Cohort Studies; D004322:Drainage; D005260:Female; D005774:Gastrostomy; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D010192:Pancreatic Pseudocyst / Q000150:complications / Q000473:pathology / Q000601:surgery*; D010195:Pancreatitis / Q000150:complications / Q000601:surgery; D012189:Retrospective Studies; D016896:Treatment Outcome