title: Positron emission tomography and breast lesions: low FDG activity in early phase imaging is not essentially benign.
abstract: The frequency of malignancy with low FDG uptake is significant and often presents diagnostic challenges. The usefulness of dual-time point FDG-PET/CT imaging (including early "after 45 minutes" and delayed "after 100 minutes," phases after radionuclide administration) for detection of such tumors has been documented. The authors present 2 cases of pathologically proven breast cancer with minimally increased FDG uptake on the initial scan (maximum standardized uptake value; SUVmax <2.5). Detection was improved by performing a dynamic PET study with early and delayed scans. Patients with a poorly visualized breast lesion due to minimal FDG uptake on the initial FDG-PET images should not be considered as benign and deserves further delayed phase imaging.
authors.affiliation: Department of Radiology, Menoufiya University School of Medicine, Shebin El-Koom, Menoufiya, Egypt. ashradio@gmail.com
authors.forename: Ashraf Anas
authors.initials: AA
authors.lastname: Zytoon
authors.forename: Koji
authors.initials: K
authors.lastname: Murakami
authors.forename: Mohamed Ramdan
authors.initials: MR
authors.lastname: El-Kholy
authors.forename: Osama
authors.initials: O
authors.lastname: Ebied
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed
chemical_list: D019788:Fluorodeoxyglucose F18