title: J-difference lactate editing at 3.0 Tesla in the presence of strong lipids.
abstract: OBJECTIVE
  To implement in vivo detection of lactate in the presence of lipids by proton magnetic resonance spectroscopy at a 3 Tesla (T) field strength for potential applications in human tumors outside of the brain.
  
  
  METHODS
  The BASING J-difference sequence was implemented in the presence of high lipid concentrations in phantoms and in vivo at 3 Tesla.
  
  
  RESULTS
  The effectiveness of the lactate editing scheme is demonstrated in phantoms containing both lactate and lipids and in vivo in ischemic induced human muscle.
  
  
  CONCLUSIONS
  The ability of the BASING J-difference technique to detect lactate in the presence of strong lipid signals outside the brain at 3T is feasible. This robust technique should permit noninvasive lactate measurements in human tumors to investigate its potential as a prognostic indicator.
authors.affiliation: Department of Medical Physics, Mail Box 84, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA. smithm3@mskcc.org
authors.forename: Mari A
authors.initials: MA
authors.lastname: Smith
authors.forename: Jason A
authors.initials: JA
authors.lastname: Koutcher
authors.forename: Kristen L
authors.initials: KL
authors.lastname: Zakian
mesh_terms: D006801:Humans; D019344:Lactic Acid / Q000032:analysis*; D008055:Lipids / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D018482:Muscle, Skeletal / Q000737:chemistry; D019047:Phantoms, Imaging; D012815:Signal Processing, Computer-Assisted
chemical_list: D008055:Lipids; D019344:Lactic Acid