[New functions of NEMO, the regulatory subunit of IKK].
The key role of NEMO, the regulatory subunit of IKK, in the NF-kB activation process is firmly established. A series of recent publications suggests that this protein also participates in the genotoxic response, after modification by sumoylation in the nucleus, and coordinates the activation of both NF-kB and IRFs during viral infection, through its interaction with TANK adaptor and TBK1/IKKepsilon kinases.
Gautheron
Jérémie
J
Inserm U781, Université René Descartes, Paris V, Tour Lavoisier, Hôpital Necker-Enfants Malades, 149, rue de Sèvres, 75015 Paris, France.
Courtois
Gilles
G
D002467:Cell Nucleus / Q000502:physiology; D003593:Cytoplasm / Q000502:physiology; D006801:Humans; D051550:I-kappa B Kinase / Q000502:physiology*; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000502:physiology; D021122:Protein Subunits / Q000502:physiology; D014777:Virus Diseases / Q000503:physiopathology
C491731:IKBKG protein, human; D021122:Protein Subunits; D017346:Protein Serine-Threonine Kinases; C403191:TBK1 protein, human; D051550:I-kappa B Kinase