title: Successful resolution of dermatophyte mycetoma following terbinafine treatment in two cats.
abstract: Microsporum canis sensitive to itraconazole and terbinafine was isolated from two cats presented with generalized dermatophytosis and dermatophyte mycetoma. Itraconazole therapy was withdrawn through lack of efficacy in one cat (a Persian) and unacceptable adverse effects in the other (a Maine Coon). Both cats achieved clinical and mycological cure after 12-14 weeks therapy with 26-31 mg kg(-1) terbinafine every 24 h per os (PO). Clinical signs in the Maine Coon resolved completely after 7 weeks treatment. Four weeks of therapy with additional weekly washes with a 2% chlorhexidine/2% miconazole shampoo following clipping produced a 98% reduction in the Persian cat's mycetoma, which was then surgically excised. Recurrent generalized dermatophytosis in the Persian cat has been managed with pulse therapy with 26 mg kg(-1) terbinafine every 24 h PO for 1 week in every month. No underlying conditions predisposing to dermatophytosis were found in either cat despite extensive investigation. Terbinafine administration was associated with mild to moderate lethargy in the Persian cat, but no other adverse effects or changes in blood parameters were seen. To the best of the authors' knowledge this is the first report of a dermatophyte mycetoma in a Maine Coon and of successful resolution of this condition in cats following terbinafine therapy.
authors.affiliation: The University of Liverpool Small Animal Teaching Hospital, Leahurst Campus, Chester High Road, Neston, Cheshire CH64 7TE, UK. timn@liv.ac.uk
authors.forename: T J
authors.initials: TJ
authors.lastname: Nuttall
authors.forename: A J
authors.initials: AJ
authors.lastname: German
authors.forename: S L
authors.initials: SL
authors.lastname: Holden
authors.forename: C
authors.initials: C
authors.lastname: Hopkinson
authors.forename: N A
authors.initials: NA
authors.lastname: McEwan
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D008297:Male; D008864:Microsporum / Q000187:drug effects / Q000302:isolation & purification*; D008271:Mycetoma / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D009281:Naphthalenes / Q000627:therapeutic use*; D000077291:Terbinafine
chemical_list: D000935:Antifungal Agents; D009281:Naphthalenes; D000077291:Terbinafine