title: Chaetoglobins A and B, two unusual alkaloids from endophytic Chaetomium globosum culture.
abstract: Chaetoglobins A (1) and B (2), two azaphilone alkaloid dimers with an unprecedented skeleton, were characterized from an endophytic fungus Chaetomium globosum with the former ascertained to be a significant cytotoxin valuable for anti-tumor drug discovery.
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Ming Ge
authors.forename: Wei
authors.initials: W
authors.lastname: Yun Zhang
authors.forename: Gang
authors.initials: G
authors.lastname: Ding
authors.forename: Patchareenart
authors.initials: P
authors.lastname: Saparpakorn
authors.forename: Yong
authors.initials: Y
authors.lastname: Chun Song
authors.forename: Supa
authors.initials: S
authors.lastname: Hannongbua
authors.forename: Ren Xiang
authors.initials: RX
authors.lastname: Tan
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002597:Chaetomium / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D007546:Isoquinolines / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D010860:Pigments, Biological / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D001578:Benzopyrans; D007546:Isoquinolines; D010860:Pigments, Biological; C494154:azaphilone; C534395:chaetoglobin A; C534396:chaetoglobin B