Sulphasalazine treatment in protracted familial Mediterranean fever arthritis.
Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by self-limited attacks of fever and polyserositis. Articular involvement in early-onset FMF is a common finding characterized by non-erosive, generally asymmetric monoarthritis in large joints. Protracted FMF arthritis was reported in 2.6% of Turkish patients. An 8-year-old female who has a history of FMF for 5 years applied to our hospital with complaints of persistent swelling and pain of her left knee for 8 months. The patient had been tried to be managed with non-steroidal anti-inflammatory drugs as well as intra-articulary steroids and colchicine. However, arthritis and acute phase response persisted. With sulphasalazine, complete recovery was achieved. It is our belief that sulphasalazine can be a choice of medical treatment in protracted FMF arthritis.
Bakkaloglu
Sevcan A
SA
Department of Pediatrics, Gazi University, Ankara, Turkey.
Aksu
Tekin
T
Goker
Berna
B
Unlusoy
Aysel
A
Peru
Harun
H
Fidan
Kibriya
K
Soylemezoglu
Oguz
O
Hasanoglu
Enver
E
Buyan
Necla
N
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001168:Arthritis / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D002648:Child; D010505:Familial Mediterranean Fever / Q000150:complications*; D005260:Female; D006801:Humans; D007719:Knee Joint; D008279:Magnetic Resonance Imaging; D012460:Sulfasalazine / Q000627:therapeutic use*; D014421:Turkey
D000894:Anti-Inflammatory Agents, Non-Steroidal; D012460:Sulfasalazine