A promising anticancer and antimalarial component from the leaves of Bidens pilosa.
Bidens pilosa is used in folk medicine for various applications due to the presence of polyacetylenes, flavonoids, terpenoids, phenylpropanoids and others. Bioactivity-guided fractionation of different extracts of B. pilosa leaf showed potential in vitro anticancer and antimalarial activity and led to the identification of a potential marker compound, phenyl-1,3,5-heptatriyne. Erythrocyte osmotic fragility experiments revealed the various extracts as well as the marker component's toxicity profiles on normal blood cells.
Kumari
Priyanka
P
Analytical Chemistry Division, Central Institute of Medicinal and Aromatic Plants (CIMAP), Council of Scientific and Industrial Research (CSIR), Lucknow, India.
Misra
Kanak
K
Sisodia
Brijesh Singh
BS
Faridi
Uzma
U
Srivastava
Suchita
S
Luqman
Suiab
S
Darokar
Mahendra Pandurang
MP
Negi
Arvind Singh
AS
Gupta
Madan Mohan
MM
Singh
Subhash Chandra
SC
Kumar
Jonnala Kotesh
JK
D000480:Alkynes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D031176:Bidens / Q000737:chemistry*; D045744:Cell Line, Tumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects; D006801:Humans; D009996:Osmotic Fragility / Q000187:drug effects; D018515:Plant Leaves / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects
D000480:Alkynes; D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; C442780:plant extract, Bidens pilosa; C019518:phenylheptatriyne