Collision tumor of the large bowel in the context of advanced pregnancy and ulcerative colitis.
A woman aged 33 years, during week 30 of pregnancy, presented with metastatic, high-grade neuroendocrine cancer. Investigation revealed a collision-type primary tumor of the large bowel, containing adenocarcinoma and neuroendocrine elements. Platinum-based chemotherapy resulted in a divergent pathologic response as assessed after colectomy. The diagnosis and classification of mixed endocrine-exocrine tumors of the colon are discussed, along with treatment considerations.
Duffy
Austin
A
Deparment of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
Shia
Jinru
J
Klimstra
David
D
Temple
Larissa
L
O'Reilly
Eileen M
EM
D000328:Adult; D001706:Biopsy; D003093:Colitis, Ulcerative / Q000150:complications*; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D003113:Colonoscopy; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis* / Q000628:therapy*; D011256:Pregnancy Outcome; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed