Effect of uridine of presynaptic NMDA and kainate receptor of rat brain cortex.
It was demonstrated that uridine affects presynaptic NMDA and kainite receptors of rat brain cortex. Uridine considerably inhibited (45)Ca2+ uptake into synaptoneurosomes (IC50 = 7.1 x 10(-12) M) under conditions NMDA stimulation and increased it under conditions AMPA stimulation (157.8%).
Petrova
L N
LN
Laboratory of Neurochemistry of Physiologically Active Substances, Institute of Physiologically Active Substances, Russian Academy of Sciences, Chemogolovka, Moscow Region. plv@icp.ac.ru
Gabrelian
A V
AV
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects*; D051381:Rats; D018092:Kainic Acid Receptors / Q000187:drug effects*; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects; D013574:Synaptosomes / Q000378:metabolism*; D014529:Uridine / Q000494:pharmacology*
D002118:Calcium; D018092:Kainic Acid Receptors; D016194:Receptors, N-Methyl-D-Aspartate; D014529:Uridine