title: The Syndrome of Irreversible Lithium-Effectuated Neurotoxicity (SILENT): one-year follow-up of a single case.
abstract: In this article, we report the case history of a 44-year-old female patient with bipolar disorder who developed the so-called Syndrome of Irreversible Lithium-Effectuated Neurotoxicity (SILENT). A detailed description of our patient's neurologic status is provided at baseline (i.e. during lithium intoxication) and after one year of follow-up, confirming the persistency of cerebellar signs and symptoms. Although rare, our report - which shows a severe and disabling form of SILENT - underscores the need to perform a strict control of the putative risk factors argued to be associated with the development of this syndrome. In our case, the presence of fever and the administration of multiple doses of antipsychotics may have contributed to the poor outcome exhibited by the patient.
authors.affiliation: Federal Fluminense University, Miguel de Frias 245, bl 3 apt 601, Niterói, Rio de Janeiro, 24220-005, Brazil.
authors.forename: Fábio H G
authors.initials: FH
authors.lastname: Porto
authors.forename: Marco A A
authors.initials: MA
authors.lastname: Leite
authors.forename: Leonardo F
authors.initials: LF
authors.lastname: Fontenelle
authors.forename: Rogério P
authors.initials: RP
authors.lastname: Marrocos
authors.forename: Natália F
authors.initials: NF
authors.lastname: Szczerback
authors.forename: Marcos R G
authors.initials: MR
authors.lastname: de Freitas
mesh_terms: D000328:Adult; D018692:Antimanic Agents / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000188:drug therapy*; D002526:Cerebellar Diseases / Q000139:chemically induced*; D005260:Female; D006801:Humans; D018020:Lithium Compounds / Q000009:adverse effects*; D020258:Neurotoxicity Syndromes / Q000209:etiology*
chemical_list: D018692:Antimanic Agents; D018020:Lithium Compounds