Preliminary evidence of neuronal regeneration in the anoxia tolerant vertebrate brain.
Postnatal neurogenesis in response to stroke or ischemia is currently of great medical interest. In this study, we investigated the potential for neurogenesis in an anoxia tolerant vertebrate in response to global ischemia. The results suggest sustained neurogenesis in the turtle that increases after ischemic damage, thus revealing a potential physiological adaptation to repeated anoxia-reoxygenation events. This finding further emphasizes the common vertebrate phenomenon of postnatal neurogenesis, with the capacity for extensive regeneration of neurons apparent in some reptilian species.
Kesaraju
Shailaja
S
Department of Biological Sciences, Florida Atlantic University, 777 Glades Road, Boca Raton, Florida, 33431, USA. skesaraj@fau.edu
Milton
Sarah L
SL
D000704:Analysis of Variance; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000503:physiopathology*; D001973:Bromodeoxyuridine / Q000378:metabolism; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D000860:Hypoxia / Q000473:pathology* / Q000503:physiopathology; D009416:Nerve Regeneration / Q000502:physiology*; D055495:Neurogenesis / Q000502:physiology*; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D014426:Turtles
D005904:Glial Fibrillary Acidic Protein; D010751:Phosphopyruvate Hydratase; D001973:Bromodeoxyuridine