Synthesis of some pyridazinylacetic acid derivatives as a novel class of monoamine oxidase-A inhibitors.
A series of new pyridazinylacetic acid derivatives were synthesized and have been investigated for their ability to inhibit the activity of the A and B isoforms of monoamine oxidase (MAO). All compounds were found to be more selective to the MAO-A isoform with compound 5d having the highest SI values. Computational study performed with a docking technique indicated the potential of these compounds in pyridazine-based MAO-A inhibitor drug development.
Khattab
Sherine Nabil
SN
Department of Chemistry, Faculty of Science, University of Alexandria, Alexandria, Egypt.
Bekhit
Adnan Ahmed
AA
El-Faham
Ayman
A
El Massry
Abdel Moneim
AM
Amer
Adel
A
D000818:Animals; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology; D008958:Models, Molecular; D008968:Molecular Conformation; D008995:Monoamine Oxidase / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D007202:Indicators and Reagents; D008996:Monoamine Oxidase Inhibitors; D011724:Pyridazines; D012701:Serotonin; D008995:Monoamine Oxidase