title: Acute alcohol intoxication.
abstract: Acute alcohol intoxication is a clinically harmful condition that usually follows the ingestion of a large amount of alcohol. Clinical manifestations are heterogeneous and involve different organs and apparatuses, with behavioral, cardiac, gastrointestinal, pulmonary, neurological, and metabolic effects. The management of an intoxicated patient occurs mainly in the emergency department and is aimed at stabilizing the clinical condition of the patient, depending on his/her clinical presentation. One specific drug that is useful in the treatment of acute alcohol intoxication is metadoxine, which is able to accelerate ethanol excretion. In patients presenting an acute alcohol intoxication, alcohol-related disorders should be detected so that the patient can be directed to an alcohol treatment unit, where a personalized, specific treatment can be established.
authors.affiliation: Institute of Internal Medicine, Catholic University of Rome, Italy.
authors.forename: Luisa
authors.initials: L
authors.lastname: Vonghia
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Leggio
authors.forename: Anna
authors.initials: A
authors.lastname: Ferrulli
authors.forename: Marco
authors.initials: M
authors.lastname: Bertini
authors.forename: Giovanni
authors.initials: G
authors.lastname: Gasbarrini
authors.forename: Giovanni
authors.initials: G
authors.lastname: Addolorato
mesh_terms: D000208:Acute Disease; D000427:Alcohol Deterrents / Q000008:administration & dosage*; D000435:Alcoholic Intoxication / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D001259:Ataxia / Q000209:etiology; D003128:Coma / Q000209:etiology; D003937:Diagnosis, Differential; D004338:Drug Combinations; D004632:Emergency Medical Services; D000431:Ethanol / Q000009:adverse effects; D019317:Evidence-Based Medicine; D005440:Fluid Therapy; D005684:Gait; D006801:Humans; D007175:Impulsive Behavior / Q000209:etiology; D008569:Memory Disorders / Q000209:etiology; D019964:Mood Disorders / Q000209:etiology; D011736:Pyridoxine / Q000008:administration & dosage*; D011761:Pyrrolidonecarboxylic Acid / Q000008:administration & dosage*; D016032:Randomized Controlled Trials as Topic; D053608:Stupor / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D000427:Alcohol Deterrents; D004338:Drug Combinations; D000431:Ethanol; C037845:metadoxine; D011736:Pyridoxine; D011761:Pyrrolidonecarboxylic Acid