Preliminary study of pulsed-electromagnetic fields effects on endothelial (HUVEC) cell secretions--modulation of the thrombo-hemorrhagic balance.
We investigated the role of low-amplitude magnetic pulse with low repetition frequency superimposed on the environmental electromagnetic field (EMF) on the secretion of anti-aggregant (Prostacyclin or PGI(2)) and pro-aggregant (Thromboxane A(2)) agents in endothelial cells of the human umbilical cord vein (HUVEC). We established that magnetic pulse exposure modulates both PGI(2) and TXA(2). These modulations depend on the frequency, width of the pulse, and intensity of the magnetic field. Moreover, we corroborated previous results obtained with an endothelial cell line (EaHy-926), concerning the increased thrombo-embolic risk for the 1 Hz frequency.
Caprani
Adrien
A
Universite Paris-Diderot, Batiment Condorcet, Paris, France.
Richert
Alain
A
Guglielmi
Jean-Paul
JP
Flaud
Patrice
P
D000818:Animals; D002460:Cell Line; D004574:Electromagnetic Fields; D042783:Endothelial Cells / Q000378:metabolism* / Q000528:radiation effects*; D011464:Epoprostenol / Q000378:metabolism; D006470:Hemorrhage / Q000378:metabolism*; D006801:Humans; D010972:Platelet Activating Factor / Q000378:metabolism; D010975:Platelet Aggregation Inhibitors / Q000378:metabolism; D013927:Thrombosis / Q000378:metabolism*; D013928:Thromboxane A2 / Q000378:metabolism; D013997:Time Factors
D010972:Platelet Activating Factor; D010975:Platelet Aggregation Inhibitors; D013928:Thromboxane A2; D011464:Epoprostenol