title: Effects of UCP2 and UCP3 variants on the manifestation of overweight in Korean children.
abstract: To investigate the associations of uncoupling protein (UCP)2 and UCP3 gene variants with overweight and related traits, we genotyped UCP2-866G>A, UCP2Ala55Val, and UCP3-55C>T in 737 Korean children and 732 adults and collected data regarding anthropometric status and blood biochemistry. Information concerning the children's lifestyles and dietary habits was collected. The UCP2-866G>A and UCP3-55C>T gene variants showed significant associations with BMI level, waist circumference, and body weight in the children but not in the adults. Compared with -866GG carriers, the -866GA and AA carriers showed a strong decreasing trend in the risk for overweight (odds ratio (OR), 0.67; 95% confidence interval (CI), 0.45-1.01; P = 0.053). In comparison with UCP3-55CC carriers, children carrying -55CT and TT showed a significant reduction in the risk of overweight (OR, 0.67; 95% CI, 0.46-0.98; P = 0.039). There was also evidence of interactions between the effects of the combined UCP2-UCP3 genotype and obesity-related metabolic traits. The greatest protective effect against overweight was seen in those with the combined genotype non-UCP2-866GG and non-UCP3-55CC, as compared with those carrying both UCP2-866GG and UCP3-55CC (OR,0.60; 95% CI, 0.38-0.95; P = 0.030). In the subgroup with a low level of physical activity, UCP3-55CC carriers had higher BMI values than UCP3-55T carriers (16.6 +/- 2.3 kg/m(2) vs. 16.1 +/- 1.9 kg/m(2), P = 0.016). Low physical activity may aggravate the susceptibility to overweight in UCP2-866GG and UCP3-55CC carriers.
authors.affiliation: Division of Metabolic Diseases, Center for Biomedical Sciences, Korean National Institute of Health, Seoul, Republic of Korea.
authors.forename: H S
authors.initials: HS
authors.lastname: Jun
authors.forename: In K
authors.initials: IK
authors.lastname: Kim
authors.forename: H J
authors.initials: HJ
authors.lastname: Lee
authors.forename: H J
authors.initials: HJ
authors.lastname: Lee
authors.forename: Jae H
authors.initials: JH
authors.lastname: Kang
authors.forename: J R
authors.initials: JR
authors.lastname: Kim
authors.forename: Hyoung D
authors.initials: HD
authors.lastname: Shin
authors.forename: J
authors.initials: J
authors.lastname: Song
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D001835:Body Weight / Q000235:genetics / Q000502:physiology; D002648:Child; D004435:Eating / Q000502:physiology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006306:Health Surveys; D006801:Humans; D007473:Ion Channels / Q000235:genetics*; D007723:Korea / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D024101:Mitochondrial Proteins / Q000235:genetics*; D009043:Motor Activity / Q000502:physiology; D009765:Obesity / Q000453:epidemiology* / Q000208:ethnology / Q000235:genetics*; D050177:Overweight / Q000453:epidemiology* / Q000208:ethnology / Q000235:genetics*; D012307:Risk Factors; D000071246:Uncoupling Protein 2; D000071247:Uncoupling Protein 3; D055105:Waist Circumference / Q000235:genetics / Q000502:physiology
chemical_list: D007473:Ion Channels; D024101:Mitochondrial Proteins; C000604389:UCP2 protein, human; C000604392:UCP3 protein, human; D000071246:Uncoupling Protein 2; D000071247:Uncoupling Protein 3