title: The effectiveness of the treatment of octreotide on chylous ascites after liver cirrhosis.
abstract: Octreotide is a crucial drug used for treating patients with chylous ascites; however, there have been few reports related to octreotide that are being used in cirrhotic patients. Thus, this thesis is designed to determine the effects of octreotide on patients with chylous ascites after liver cirrhosis. Eight patients were diagnosed with chylous ascites, on the basis of laboratory findings on ascites samples, between January 2003 and May 2008. Octreotide was given to the six patients, while the remaining two were treated as a control. All patients had persistent peritoneal drainage with the quantity and quality of the drainage fluid observed once every other day. All the necessary care was individually given to the patients during the therapy. All patients properly received combined therapy including a low-fat and low-sodium diet, and diuretic and peritoneal drainage. The volume of the peritoneal drainage was reduced to zero in one of the six patients who received octreotide therapy, while the other five had the drainage volumes decreased from 2,000 to 50 ml with a clear appearance and negative qualitative analysis of chyle. For those two patients who did not receive octreotide therapy, the conditions of peritoneal drainage seldom changed both from the qualitative and quantitative aspects. In conclusion, Octreotide, along with combined therapy, can rapidly relieve portal hypertension and reduce triglyceride levels in ascites. It appears to be an effective therapy available for the treatment of chylous ascites caused by liver cirrhosis.
authors.affiliation: Department of Comprehensive Treatment II, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 225 Changhai Road, Shanghai, China. dongxunzhou@yahoo.com.cn
authors.forename: Dong Xun
authors.initials: DX
authors.lastname: Zhou
authors.forename: Hua Bang
authors.initials: HB
authors.lastname: Zhou
authors.forename: Qing
authors.initials: Q
authors.lastname: Wang
authors.forename: Shan Shan
authors.initials: SS
authors.lastname: Zou
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.forename: He Ping
authors.initials: HP
authors.lastname: Hu
mesh_terms: D002915:Chylous Ascites / Q000097:blood / Q000188:drug therapy* / Q000209:etiology*; D004322:Drainage; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000627:therapeutic use*; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
chemical_list: D005765:Gastrointestinal Agents; D014280:Triglycerides; D015282:Octreotide