Impaired leptin activity in New Zealand Obese mice: model of angiogenesis.
Leptin is prompt to drive angiogenesis, effecting proper vascularisation. Tissue remodeling (including adipose organ) is associated with the angiogenic response. The aim of this study was to investigate the effect of hyperleptinemia on angiogenesis in subcutaneous (s.c.) in vivo matrigel model in mice on a high fat (HF) diet. HF promoted adipose tissue accumulation and biochemical changes resembling metabolic syndrome. However, the impact of this dietary treatment on angiogenesis, measured in s.c. matrigel model was not significant. Changes in leptin concentration were not accompanied by significant angiogenic response. This lack of leptin activity and impaired signal transduction at the molecular level suggests malfunction of the leptin receptor in NZO mice.
Wator
Lukasz
L
Department of Clinical Biochemistry, Jagiellonian University Medical College, Kopernika 15a, 31-501, Cracow, Poland, lwator@cm-uj.krakow.pl.
Razny
Urszula
U
Balwierz
Adriana
A
Polus
Anna
A
Joost
Hans G
HG
Dyduch
Grzegorz
G
Tomaszewska
Romana
R
Dembinska-Kiec
Aldona
A