title: [Preparation and antibacterial activity of quaternary ammonium salt monomers].
abstract: OBJECTIVE
  To prepare three quaternary ammonium salt (QAS) monomers, and to compare their antibacterial activities against four oral bacterial strains.
  
  
  METHODS
  Three antibacterial monomers [methacryloxyethyl benzyl dimethyl ammonium chloride (DMAE-BC), methacryloxyethyl m-chloro benzyl dimethyl ammonium chloride (DMAE-m-CBC), methacryloxyethyl cetyl dimethyl ammonium chloride (DMAE-CB)] were synthesized according to the general structure of target monomers. Their antibacterial effects were investigated using the broth dilution test on Gram-positive and Gram-negative bacterial strains (Streptococcus mutans, Streptococcus sanguis, Porphyromonas gingivalis, Prevotella melaninogenica ).
  
  
  RESULTS
  Three different monomers were successfully obtained. All the tested bacterial strains were susceptible to the three monomers, among which DMAE-CB exhibited the lowest minimal inhibitory concentrations (MIC) ranging from 1.2 to 4.8 mg/L.
  
  
  CONCLUSIONS
  All these three QAS monomers have different antibacterial activities against four oral bacteria strains. The data indicate that DMAE-CB may be a candidate antibacterial agent for oral infectious diseases.
authors.affiliation: Department of Prosthodontics, College of Stomatology, The Fourth Military Medical University, Xi'an, China.
authors.forename: Yu-Hong
authors.initials: YH
authors.lastname: Xiao
authors.forename: Ji-Hua
authors.initials: JH
authors.lastname: Chen
authors.forename: Ming
authors.initials: M
authors.lastname: Fang
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Xing
authors.forename: Fang
authors.initials: F
authors.lastname: Li
authors.forename: Zhi-Guo
authors.initials: ZG
authors.lastname: Chai
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D003764:Dental Materials / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D000644:Quaternary Ammonium Compounds / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D003764:Dental Materials; D000644:Quaternary Ammonium Compounds