Association of IL-18 gene polymorphism (-137C) with arthritis manifestations in SLE: combined effect with IFN gamma gene polymorphism (+874A).
We analyzed the association between single nucleotide polymorphisms in IL-12 and IL-18 genes in disease susceptibility and severity of SLE in Thais. A weak association was observed between A allele of the IL-12 gene at the 3' untranslated region in SLE patients with proteinuria (OR = 1.89, 95% CI = 1.05-3.40, P = 0.02, Pc = 0.06). In addition, we found a significant association between C allele of IL-18 (-137) with arthritis (OR = 6.88, 95% CI = 1.54-42.93, P = 0.003, Pc = 0.009). The presence of one C allele (C/C+C/G) was associated with significant OR of 8.72 (95% CI = 1.83-56.71, P = 0.001, Pc = 0.003). Interestingly, we found the combined effect between the G/C genotype of IL-18 (-137) and the A/A genotype of IFNG (+874) gene causing susceptibility of arthritis in SLE patients (OR = 13.22, 95% CI = 1.56-291.66, P = 0.004).
Hirankarn
Nattiya
N
Lupus Research Unit, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Rama 4 Road, Bangkok 10330, Thailand. fmednpt@md.chula.ac.th
Tangwattanachuleeporn
Marut
M
Wongpiyabovorn
Jongkonnee
J
Wongchinsri
Jeerapat
J
Avihingsanon
Yingyos
Y
D000328:Adult; D000483:Alleles; D001168:Arthritis / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D018664:Interleukin-12 / Q000235:genetics; D020382:Interleukin-18 / Q000235:genetics*; D008180:Lupus Erythematosus, Systemic / Q000208:ethnology / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011507:Proteinuria / Q000208:ethnology / Q000235:genetics; D012720:Severity of Illness Index; D013785:Thailand
D020382:Interleukin-18; D018664:Interleukin-12; D007371:Interferon-gamma