title: Discontinued drugs in 2007: anti-infectives.
abstract: Twelve drugs related to therapy and/or prevention of infectious diseases were discontinued from development during 2007. All of these agents were aimed at viral infections, primarily hepatitis C virus (six agents) and HIV (five agents). Nearly half were vaccines, including three against HIV, a therapeutic vaccine for hepatitis C, and a vaccine for prevention and treatment of herpes simplex virus type 2. Each of these agents is briefly reviewed and the reasons for failure are discussed.
authors.affiliation: Infectious Diseases, Novartis Institutes for BioMedical Research Inc., 500 Technology Square, Cambridge, MA 02139, USA. neil.ryder@novartis.com
authors.forename: Neil S
authors.initials: NS
authors.lastname: Ryder
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000009:adverse effects / Q000600:supply & distribution*; D006801:Humans; D013997:Time Factors; D017211:Treatment Failure; D014765:Viral Vaccines / Q000600:supply & distribution
chemical_list: D000890:Anti-Infective Agents; D014765:Viral Vaccines