Type 1 adenylyl cyclase is essential for maintenance of remote contextual fear memory.
Although molecular mechanisms for hippocampus-dependent memory have been extensively studied, much less is known about signaling events important for remote memory. Here we report that mice lacking type 1 adenylyl cyclase (AC1) are able to establish and retrieve remote contextual memory but unable to sustain it as long as wild-type mice. Interestingly, mice overexpressing AC1 show superior remote contextual memory even though they exhibit normal hippocampus-dependent contextual memory. These data illustrate that calcium coupling to cAMP contributes to the stability of remote memory and identifies AC1 as a potential drug target site to improve long-term remote memory.
Shan
Qiang
Q
Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA.
Chan
Guy C-K
GC
Storm
Daniel R
DR
D000262:Adenylyl Cyclases / Q000235:genetics*; D000818:Animals; D020013:Calcium Signaling / Q000235:genetics; D003213:Conditioning, Psychological / Q000502:physiology; D000242:Cyclic AMP / Q000378:metabolism*; D005239:Fear / Q000502:physiology*; D006179:Gyrus Cinguli / Q000201:enzymology / Q000503:physiopathology; D006624:Hippocampus / Q000201:enzymology* / Q000503:physiopathology; D008568:Memory / Q000502:physiology*; D008569:Memory Disorders / Q000201:enzymology* / Q000235:genetics / Q000503:physiopathology; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D009434:Neural Pathways / Q000201:enzymology / Q000503:physiopathology
D000242:Cyclic AMP; D000262:Adenylyl Cyclases; C106670:adenylyl cyclase 1