Kuguacins F-S, cucurbitane triterpenoids from Momordica charantia.
Chemical investigation of the vines and leaves of Momordica charantia resulted in isolation of fourteen cucurbitane triterpenoids, kuguacins F-S (1-14), including two pentanorcucurbitacins (6 and 7), one octanorcucurbitacin (8), and two trinorcucurbitacins (11 and 12), along with six known analogues. Their structures were elucidated on the basis of extensive spectroscopic and single-crystal X-ray diffraction analyses. Compounds 1-14 exhibited weak anti-HIV-1 activities in vitro.
Chen
Jian-Chao
JC
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PR China.
Liu
Wu-Qing
WQ
Lu
Lu
L
Qiu
Ming-Hua
MH
Zheng
Yong-Tang
YT
Yang
Liu-Meng
LM
Zhang
Xian-Min
XM
Zhou
Lin
L
Li
Zhong-Rong
ZR
D008958:Models, Molecular; D015394:Molecular Structure; D029777:Momordica charantia / Q000737:chemistry*; D035261:Plant Components, Aerial / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry*
D014315:Triterpenes