title: Conversion of FDG PET activity of fibrous dysplasia of the skull late in life mimicking metastatic disease.
abstract: Fibrous dysplasia (FD) accounts for 7% of benign bone tumors. It is a developmental disorder of unclear etiology. The lamellar cancellous bone of the medullary cavity is replaced with immature fibroosseous tissue. We describe a case of FD of the skull in a patient of advanced age (69 years) with recent diagnosis of colon cancer, which changed its FDG activity and CT appearance within 10 months of follow-up. Surgical biopsy confirmed FD. Several case reports describe FDG-avid FD, but conversion of metabolic activity late in life is probably unusual.
authors.affiliation: Department of Radiology, The Johns Hopkins Hospital, Baltimore, Maryland, USA. dboneka1@jhmi.edu
authors.forename: David
authors.initials: D
authors.lastname: Bonekamp
authors.forename: Heather
authors.initials: H
authors.lastname: Jacene
authors.forename: Detlef
authors.initials: D
authors.lastname: Bartelt
authors.forename: Nafi
authors.initials: N
authors.lastname: Aygun
mesh_terms: D000368:Aged; D005357:Fibrous Dysplasia of Bone / Q000000981:diagnostic imaging*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging; D018716:Molecular Mimicry; D009362:Neoplasm Metastasis / Q000473:pathology*; D049268:Positron-Emission Tomography; D012886:Skull / Q000000981:diagnostic imaging* / Q000473:pathology*; D013702:Temporal Lobe / Q000473:pathology
chemical_list: D019788:Fluorodeoxyglucose F18