Rpn10 protects the proteasome from Dsk2.
In a recent issue of Molecular Cell, Matiuhin et al. (2008) reveal how the ubiquitin receptor Dsk2 becomes deleterious to cells and that it is kept in check by Rpn10, which restricts its access to the proteasome.
Walters
Kylie J
KJ
Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA. walte048@umn.edu
Zhang
Naixia
N
D002352:Carrier Proteins / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000737:chemistry / Q000378:metabolism*; D008954:Models, Biological; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism; D014452:Ubiquitins / Q000737:chemistry / Q000378:metabolism*
D002352:Carrier Proteins; D018797:Cell Cycle Proteins; C100415:DSK2 protein, S cerevisiae; C122019:RPN10 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D025801:Ubiquitin; D014452:Ubiquitins; D046988:Proteasome Endopeptidase Complex