title: Correlation-based multivariate analysis of genetic influence on brain volume.
abstract: Considerable research effort has focused on achieving a better understanding of the genetic correlates of individual differences in volumetric and morphological brain measures. The importance of these efforts is underlined by evidence suggesting that brain changes in a number of neuropsychiatric disorders are at least partly genetic in origin. The currently used methods to study these relationships are mostly based on single-genotype univariate analysis techniques. These methods are limited as multiple genes are likely to interact with each other in their influences on brain structure and function. In this paper we present a feasibility study where we show that by using kernel correlation analysis, with a new genotypes representation, it is possible to analyse the relative associations of several genetic polymorphisms with brain structure. The implementation of the method is demonstrated on genetic and structural magnetic resonance imaging (MRI) data acquired from a group of 16 healthy subjects by showing the multivariate genetic influence on grey and white matter.
authors.affiliation: Computational Statistics & Machine Learning Centre, Dept. of Computer Science, University College London, London WC1E 6BT, United Kingdom. D.Hardoon@cs.ucl.ac.uk
authors.forename: David R
authors.initials: DR
authors.lastname: Hardoon
authors.forename: Ulrich
authors.initials: U
authors.lastname: Ettinger
authors.forename: Janaina
authors.initials: J
authors.lastname: Mourão-Miranda
authors.forename: Elena
authors.initials: E
authors.lastname: Antonova
authors.forename: David
authors.initials: D
authors.lastname: Collier
authors.forename: Veena
authors.initials: V
authors.lastname: Kumari
authors.forename: Steven C R
authors.initials: SC
authors.lastname: Williams
authors.forename: Michael
authors.initials: M
authors.lastname: Brammer
mesh_terms: D000293:Adolescent; D000328:Adult; D000886:Anthropometry / Q000379:methods; D001921:Brain / Q000033:anatomy & histology* / Q000254:growth & development*; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D015999:Multivariate Analysis; D009413:Nerve Fibers, Myelinated / Q000502:physiology / Q000648:ultrastructure; D009929:Organ Size / Q000235:genetics; D010363:Pattern Recognition, Automated / Q000379:methods; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D055815:Young Adult