title: Clinical characteristics and prognosis of orbital invasive aspergillosis.
abstract: OBJECTIVE
  To evaluate the clinical characteristics and prognosis of orbital invasive aspergillosis, a major cause of morbidity and mortality in immunocompromised patients.
  
  
  METHODS
  Review of the medical records of Severance Hospital, Yonsei University College of Medicine, from 1995 to 2007 revealed 15 patients with orbital invasive aspergillosis. A retrospective cohort study was conducted to evaluate the clinical characteristics, radiologic findings, associated underlying diseases, and prognosis. Risk factors for mortality were analyzed.
  
  
  RESULTS
  A total of 15 cases of orbital invasive aspergillosis were included in this study. The mean age for all patients was 61.9 years. The most common underlying disease was diabetes mellitus and all patients had paranasal sinus infections. The most common ocular symptoms were visual disturbance, periorbital swelling, and periorbital pain. The mortality rate associated with invasive aspergillosis was 40%. According to univariate analysis, variables significantly associated with invasive aspergillosis-related mortality included fever and incorrect initial diagnosis.
  
  
  CONCLUSIONS
  Fever and incorrect initial diagnosis were found to be associated with high mortality rates in patients with orbital invasive aspergillosis. Further study is necessary to determine optimal strategies for early diagnosis and appropriate treatment.
authors.affiliation: Department of Ophthalmology, Kim's Eye Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Hye Sun
authors.initials: HS
authors.lastname: Choi
authors.forename: Jun Yong
authors.initials: JY
authors.lastname: Choi
authors.forename: Jin Sook
authors.initials: JS
authors.lastname: Yoon
authors.forename: Sung Joo
authors.initials: SJ
authors.lastname: Kim
authors.forename: Sang Yeul
authors.initials: SY
authors.lastname: Lee
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy; D003646:Debridement / Q000379:methods; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D015821:Eye Infections, Fungal / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D017052:Hospital Mortality / Q000639:trends; D006801:Humans; D015994:Incidence; D007723:Korea / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D013508:Ophthalmologic Surgical Procedures / Q000379:methods; D009915:Orbit; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate / Q000639:trends; D014057:Tomography, X-Ray Computed
chemical_list: D000935:Antifungal Agents