Studies on coumestrol/beta-cyclodextrin association: Inclusion complex characterization.
Coumestrol is an estrogenic and antioxidant agent, characterized by its low solubility in aqueous and lipophilic media, once in the aglicone form. In order to improve its solubility in water, coumestrol was associated with beta-cyclodextrin in aqueous media followed by freeze-drying and characterized by SEM, (1)H NMR and molecular modeling. The analysis proved the existence of an inclusion complex, with higher probability of inclusion of the coumestrol B-ring into the wider rim of the beta-cyclodextrin molecule.
Franco
Camila
C
Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul. Av. Ipiranga, 2752, Porto Alegre 90.610-000, RS, Brazil.
Schwingel
Liege
L
Lula
Ivana
I
Sinisterra
Rubén D
RD
Koester
Letícia Scherer
LS
Bassani
Valquiria Linck
VL
D002627:Chemistry, Physical; D003375:Coumestrol / Q000737:chemistry*; D005612:Freeze Drying; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D008958:Models, Molecular; D048789:Phytoestrogens / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry; D047392:beta-Cyclodextrins / Q000737:chemistry*
D048789:Phytoestrogens; D047392:beta-Cyclodextrins; D014867:Water; C031215:betadex; D003375:Coumestrol