title: Arterial geometry, flow pattern, wall shear and mass transport: potential physiological significance.
abstract: We have studied numerically steady and unsteady flow in a straight and a helically stented common carotid artery, in order to model porcine experimental results that show reduced intimal hyperplasia (IH) in the helical case. The combination of flow pulsatility and three-dimensionality generates a sweeping motion of the Dean vortices, which overall reduced extremes of both oxygen flux to the vessel wall and wall shear stress (WSS). Since IH and atherosclerosis affect preferentially low WSS regions, these findings imply that vessel three-dimensionality and flow pulsatility can play important protective roles in respect of these diseases. The amplitude and frequency of the velocity waveform are important parameters of the system. Increase in amplitude increases WSS and oxygen flux to the vessel wall. Increase in frequency has a small effect; it increases WSS but has no effect on the oxygen flux to the vessel wall.
authors.affiliation: Department of Bioengineering, Imperial College, London SW7 2AZ, UK. g.coppola@imperial.ac.uk
authors.forename: G
authors.initials: G
authors.lastname: Coppola
authors.forename: C
authors.initials: C
authors.lastname: Caro
mesh_terms: D000818:Animals; D002339:Carotid Arteries / Q000473:pathology / Q000502:physiology* / Q000601:surgery; D003198:Computer Simulation; D008955:Models, Cardiovascular; D012039:Regional Blood Flow / Q000502:physiology*; D033081:Shear Strength; D015607:Stents; D013552:Swine / Q000097:blood*