title: The effects of Asian population substructure on Y STR forensic analyses.
abstract: A total of 3046 males of Chinese, Malay, Thai, Japanese, and Indian population affinity were previously typed for the Y STR loci DYS19, DYS385 (counted as two loci), DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS437, DYS438, DYS439, DYS456, DYS458, DYS635, DYS448, and Y GATA H4 using the AmpFlSTR Yfiler kit. These samples were assessed for population genetic parameters that impact forensic statistical calculations. All population samples were highly polymorphic for the 16 Y STR markers with the marker DYS385 being the most polymorphic, because it is comprised of two loci. Most (2677 out of a total of 2806 distinct haplotypes) of the 16 marker haplotypes observed in the sample populations were represented only once in the data set. Haplotype diversities were greater than 99.57% for the Chinese, Malay, Thai, Japanese, and Indian sample populations. For the Y STR markers, population substructure correction was considered when calculating the rarity of a Y STR profile. An F(ST) value, rather than a R(ST) value, is more appropriate under a forensic model. Because the F(ST) values are very small within the Asian populations, the estimate of the rarity of a haplotype comprised of 10-16 markers does not need substructure correction. However haplotypes with fewer markers may require F(ST) corrections when calculating the rarity of the profile.
authors.affiliation: Federal Bureau of Investigation, Quantico, VA 22135, USA. bruce.budowle@ic.fbi.gov
authors.forename: Bruce
authors.initials: B
authors.lastname: Budowle
authors.forename: Jianye
authors.initials: J
authors.lastname: Ge
authors.forename: Joyce
authors.initials: J
authors.lastname: Low
authors.forename: Crystal
authors.initials: C
authors.lastname: Lai
authors.forename: Wong Hang
authors.initials: WH
authors.lastname: Yee
authors.forename: Grace
authors.initials: G
authors.lastname: Law
authors.forename: Wai Fun
authors.initials: WF
authors.lastname: Tan
authors.forename: Yuet Meng
authors.initials: YM
authors.lastname: Chang
authors.forename: Revathi
authors.initials: R
authors.lastname: Perumal
authors.forename: Phoon Yoong
authors.initials: PY
authors.lastname: Keat
authors.forename: Natsuko
authors.initials: N
authors.lastname: Mizuno
authors.forename: Kentaro
authors.initials: K
authors.lastname: Kasai
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Sekiguchi
authors.forename: Ranajit
authors.initials: R
authors.lastname: Chakraborty
mesh_terms: D001208:Asia; D044466:Asian People / Q000235:genetics*; D041322:Chromosomes, Human, Y; D016172:DNA Fingerprinting; D005819:Genetic Markers; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D020080:Tandem Repeat Sequences
chemical_list: D005819:Genetic Markers