title: Multicentric occurrence and spread of hepatocellular carcinoma in whole explanted end-stage liver.
abstract: OBJECTIVE
  Hepatocellular carcinoma (HCC) arising from the end stages of liver cirrhosis is a fair indication for liver transplantation (LT). To pathologically investigate the multicentric occurrence of relatively early staged HCC in cirrhosis, we studied whole explanted livers.
  
  
  METHODS
  Fourteen explanted livers from patients undergoing living donor LT (LDLT) were examined. The stage of the HCCs was judged to be within the Milan criteria (M-C; a single HCC less than 5 cm or three HCCs less than 3 cm). Histological examination was performed using serially sectioned specimens 5-7 mm in width. Characterization of preoperatively detectable and undetectable lesions was also performed.
  
  
  RESULTS
  In nine patients (64.3%), a total of 34 nodules were found after whole liver histological examination (WLHE). In five patients (31%), the results exceeded the M-C. The characteristics of undetectable HCCs included a minute (median size 6 mm), well-differentiated appearance (80%), with indistinct margins (85.3%) and without vascular invasion (94%). There was no recurrence in any patients at the time of follow up (median follow-up period, 30.1 months).
  
  
  CONCLUSIONS
  A multicentric occurrence of HCCs was demonstrated in cirrhotic livers with HCCs within the M-C. Undetectable HCCs in cirrhotic livers may have no impact on recurrence after LT.
authors.affiliation: Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Hidaka
authors.forename: Susumu
authors.initials: S
authors.lastname: Eguchi
authors.forename: Sadayuki
authors.initials: S
authors.lastname: Okudaira
authors.forename: Mitsuhisa
authors.initials: M
authors.lastname: Takatsuki
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Tokai
authors.forename: Akihiko
authors.initials: A
authors.lastname: Soyama
authors.forename: Shigeki
authors.initials: S
authors.lastname: Nagayoshi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Mochizuki
authors.forename: Koji
authors.initials: K
authors.lastname: Hamasaki
authors.forename: Yoshitsugu
authors.initials: Y
authors.lastname: Tajima
authors.forename: Takashi
authors.initials: T
authors.lastname: Kanematsu