5-(123)I-A-85380 binding to the α4β2-nicotinic receptor in mild cognitive impairment.
Treatments currently licensed for Alzheimer's dementia target cholinergic brain systems. In vivo nicotinic receptor binding may provide an early marker of illness and treatment suitability. In this pilot, we examined nine patients with amnestic mild cognitive impairment (MCI) and 10 age and education matched healthy volunteers with high resolution SPECT and the nicotinic receptor ligand 5-(123)I-A-85380. Uptake data were analysed using voxel-based techniques for group comparisons and regression analyses with cognitive impairment as covariates. MCI patients had discrete reductions in uptake in medial temporal cortex. Correlations with cognitive impairment were found in left temporo-parietal areas (Addenbrooke's Cognitive Examination) and bilateral temporo-limbic areas (Rey Auditory Verbal Learning Test), and right parahippocampal gyrus (Rey Complex Figure Test) within the patient group. In vivo nicotinic receptor binding appears to be sensitive to brain changes in MCI. Larger scale explorations of patients undergoing treatment will be necessary to evaluate its use in predicting or monitoring treatment response.
Terrière
Emma
E
Division of Psychiatry, University of Edinburgh, UK.
Dempsey
Mary F
MF
Herrmann
Lucie L
LL
Tierney
Kevin M
KM
Lonie
Jane A
JA
O'Carroll
Ronan E
RE
Pimlott
Sally
S
Wyper
David J
DJ
Herholz
Karl
K
Ebmeier
Klaus P
KP
D000368:Aged; D000369:Aged, 80 and over; D001384:Azetidines / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000503:physiopathology; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000378:metabolism; D008032:Limbic System / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D016555:Matched-Pair Analysis; D009483:Neuropsychological Tests; D020534:Parahippocampal Gyrus / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D010296:Parietal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D010865:Pilot Projects; D011725:Pyridines / Q000378:metabolism*; D011978:Receptors, Nicotinic / Q000378:metabolism*; D012016:Reference Values; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D015899:Tomography, Emission-Computed, Single-Photon
C426745:5-iodo-3-(2-azetidinylmethoxy)pyridine; D001384:Azetidines; D007457:Iodine Radioisotopes; D011725:Pyridines; D011978:Receptors, Nicotinic; C403531:nicotinic receptor alpha4beta2