title: Antiplasmodial alkaloids from Desmos rostrata.
abstract: Two new alkaloids, desmorostratine (1) and discretine N-oxide (2), were isolated from the stem bark of Desmos rostrata, together with five known alkaloids, discretine (3), dehydrodiscretine (4), pseudocolumbamine (5), predicentrine (6), and aristolactam AII (7). The structures were established on the basis of spectroscopic data, including mass spectrometry and 2D-NMR. Compound 1 was cytotoxic against KB cells (IC(50) 2.4 microM), while 2, 3, and 4 inhibited Plasmodium falciparum (IC(50) of 4.2, 1.6, and 0.9 microM, respectively).
authors.affiliation: Institute of Chemistry, VAST, 18 Hoang Quoc Viet Road, Caugiay, Hanoi.
authors.forename: Ngoc Tuan
authors.initials: NT
authors.lastname: Nguyen
authors.forename: Van Cuong
authors.initials: VC
authors.lastname: Pham
authors.forename: Marc
authors.initials: M
authors.lastname: Litaudon
authors.forename: Françoise
authors.initials: F
authors.lastname: Guéritte
authors.forename: Philippe
authors.initials: P
authors.lastname: Grellier
authors.forename: Van Tuyen
authors.initials: VT
authors.lastname: Nguyen
authors.forename: Van Hung
authors.initials: VH
authors.lastname: Nguyen
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D007624:KB Cells; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*; D014744:Vietnam
chemical_list: D000470:Alkaloids; D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D006576:Heterocyclic Compounds, 4 or More Rings; C534633:desmorostratine; C534636:discretine; C534634:discretine N-oxide