Usefulness of pulsed arterial spin labeling MR imaging in mesial temporal lobe epilepsy.
OBJECTIVE
Arterial spin labeling (ASL) is a developing magnetic resonance imaging (MRI) method for noninvasive measurement of cerebral blood flow (CBF). The purpose of this study was to evaluate the usefulness of ASL for detecting interictal temporal hypoperfusion in temporal lobe epilepsy (TLE). ASL-derived CBF measurements were compared with those derived from H(2)(15)O positron emission tomography (PET).


METHODS
11 normal controls and 10 patients with medically intractable TLE were studied. Pulsed ASL (PASL) with quantitative imaging of perfusion using a single subtraction, second version (QUIPSS II) was performed in all subjects and H(2)(15)O PET was performed in patients. Regional CBF values in the mesial and lateral temporal lobes were measured utilizing quantitative analysis of perfusion images. A perfusion asymmetry index (AI) was calculated for each region.


RESULTS
In patients, mean CBF in the mesial temporal lobe was not significantly different between PASL and H(2)(15)O PET, and ipsilateral mesial temporal CBF was lower than contralateral CBF with both techniques. PASL detected significant mesial temporal perfusion asymmetry agreeing with EEG laterality in four patients. H(2)(15)O PET found ipsilateral interictal hypoperfusion in three. Both scans found unilateral hypoperfusion in one patient with bilateral EEG discharges.


CONCLUSIONS
Pulsed ASL may be a promising approach to detecting interictal hypoperfusion in TLE. This method has potential as a clinical alternative to H(2)(15)O PET due to noninvasiveness and easy accessibility.
Lim
Young-Min
YM
Clinical Epilepsy Section, NINDS, NIH, Bethesda, MD 20892, USA. limy@ninds.nih.gov
Cho
Yong-Won
YW
Shamim
Sadat
S
Solomon
Jeffrey
J
Birn
Rasmus
R
Luh
Wen Ming
WM
Gaillard
William D
WD
Ritzl
Eva K
EK
Theodore
William H
WH
D000293:Adolescent; D000328:Adult; D000465:Algorithms; D002560:Cerebrovascular Circulation; D017352:Echo-Planar Imaging / Q000379:methods; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D005240:Feasibility Studies; D005260:Female; D006624:Hippocampus / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010104:Oxygen Radioisotopes; D049268:Positron-Emission Tomography; D012598:Sclerosis; D013382:Subtraction Technique; D013702:Temporal Lobe / Q000098:blood supply* / Q000000981:diagnostic imaging; D014741:Video Recording; D055815:Young Adult
D010104:Oxygen Radioisotopes