Enhanced levels of the CCR7 ligands CCL19 and CCL21 in HIV infection: correlation with viral load, disease progression and response to highly active antiretroviral therapy.
The CCR7 ligands, CCL19 and CCL21, coordinate lymph node homing of naive and central memory T cells. In untreated HIV-infected patients, serum levels of CCL19 and CCL21 showed a biphasic pattern during progression; a marked increase was followed by a decline in patients with advanced immunodeficiency. During highly active antiretroviral therapy, a decrease in CCL19/CCL21 levels was restricted to virologic responders. We suggest that dysregulation of CCR7 ligands may play an important role in progression of HIV infection.
Damås
Jan K
JK
Department of Infectious Diseases, St Olavs Hospital, Olav Kyrres gt 17, 7006 Trondheim, Norway. jan.k.damas@ntnu.no
Landrø
Linn
L
Fevang
Børre
B
Heggelund
Lars
L
Frøland
Stig S
SS
Aukrust
Pål
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D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D054415:Chemokine CCL19 / Q000097:blood*; D054421:Chemokine CCL21 / Q000097:blood*; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology* / Q000821:virology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D016896:Treatment Outcome; D019562:Viral Load; D055815:Young Adult
C515460:CCL19 protein, human; C515478:CCL21 protein, human; D054415:Chemokine CCL19; D054421:Chemokine CCL21