A new immunomodulatory therapy for severe sepsis: Ulinastatin Plus Thymosin {alpha} 1.
OBJECTIVE
To study the effect of immunomodulatory therapy with ulinastatin plus thymosin alpha( 1) on septic patients.


METHODS
A total of 56 sepsis patients were randomized into a treatment group, receiving immunomodulatory therapy, and a placebo group, a placebo. Acute Physiology and Chronic Health Evaluation II scores, clinical data, lymphocyte subsets, immunological indexes, and coagulation parameters were determined before admission and on the 3rd, 8th, and 28th day after admission to the Intensive Care Unit.


RESULTS
The treatment group experienced a 78% cumulative survival, the placebo group experienced a 60% cumulative survival; the survival difference was mirrored by Acute Physiology and Chronic Health Evaluation II scores and more quickly improved leukocyte counts, lymphocyte counts, coagulation parameters, and cytokine levels in the treatment.


CONCLUSIONS
Combined immunomodulatory therapy with ulinastatin plus thymosin alpha(1) appears to yield improved survival for patients with sepsis; this finding should be verified in larger clinical trials.
Li Yumin
Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China.
Chen Hao
Li Xun
Zhou Wence
He Minyan
Chiriva-Internati
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Wachtel
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Frezza
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EE
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000328:Adult; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006023:Glycoproteins / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018805:Sepsis / Q000188:drug therapy* / Q000401:mortality; D015996:Survival Rate; D000077596:Thymalfasin; D013947:Thymosin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016896:Treatment Outcome; D014361:Trypsin Inhibitors / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; D006023:Glycoproteins; D014361:Trypsin Inhibitors; D013947:Thymosin; C028665:urinastatin; D000077596:Thymalfasin