title: Eumycetoma caused by Cladophialophora bantiana successfully treated with itraconazole.
abstract: A 57-year-old male presented with dermatosis of the dorsum of the foot consisting of tumefaction, deformity and sinus tract formation. The direct examination of exudates as well as the biopsy tissue, demonstrated the presence of black granules. A dematiaceous fungus was isolated from the lesions and was identified by ribosomal DNA sequencing as Cladophialophora bantiana. This is the second report of this fungus as an etiologic agent of eumycetoma in humans. Clinical and mycologic cure was achieved after 20 months of treatment with itraconazole at a starting dose of 300 mg/day that was tapered during the course of therapy. The patient's isolate had an itraconazole MIC of 0.012 microg/ml.
authors.affiliation: Dermatology Service & Mycology Department, General Hospital of Mexico, Del Valle, Mexico. a_bonifaz@yahoo.com.mx
authors.forename: Alexandro
authors.initials: A
authors.lastname: Bonifaz
authors.forename: Sybren
authors.initials: S
authors.lastname: De Hoog
authors.forename: Michael R
authors.initials: MR
authors.lastname: McGinnis
authors.forename: Amado
authors.initials: A
authors.lastname: Saúl
authors.forename: Octavio
authors.initials: O
authors.lastname: Rodríguez-Cortés
authors.forename: Javier
authors.initials: J
authors.lastname: Araiza
authors.forename: Mariana
authors.initials: M
authors.lastname: Cruz
authors.forename: Patricia
authors.initials: P
authors.lastname: Mercadillo
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D001203:Ascomycota / Q000145:classification / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D005533:Foot Dermatoses / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D008271:Mycetoma / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole