A composite coating of calcium alginate and gelatin particles on Ti6Al4V implant for the delivery of water soluble drug.
A composite coating on Ti6Al4V implant was prepared from alginate and gelatin particles through a dip-coating method to control the release of the water soluble drug gentamicin and improve the surface properties of the implant. Gentamicin was dissolved in the coating or bonded to gelatin particles through Schiff base reaction. The drug release experiments in vitro showed that about 10% of gentamicin was released within 0.5 h, the release lasted for 10 days, and the release from the composite coating was dependent on the pH value. The composite coating could induce the formation of apatite on the coating surface, which was fully covered after 7 days immersing in SBF solution. In addition, Ti6Al4V plate with the composite coating had excellent antibacterial activity against Staphylococcus aureus. All of the results provided the possibility that this composite coating might be applied as a controlled release system to deliver the water soluble drug, and as a bioactive, biodegradable layer on the bio-inert implant surface to induce the formation of apatite and actively bond to the surrounding tissue in vivo.
Xiao
Junwu
J
Key Laboratory of Inorganic Coating Materials, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China, 200050.
Zhu
Yingchun
Y
Key Laboratory of Inorganic Coating Materials, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China, 200050.
Liu
Yanyan
Y
Key Laboratory of Inorganic Coating Materials, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China, 200050.
Zeng
Yi
Y
Key Laboratory of Inorganic Coating Materials, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China, 200050.
Xu
Fangfang
F
Key Laboratory of Inorganic Coating Materials, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China, 200050.
D000464:Alginates / Q000737:chemistry / Q000378:metabolism; D000497:Alloys / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001826:Body Fluids / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry / Q000378:metabolism; D016503:Drug Delivery Systems; D005780:Gelatin / Q000737:chemistry / Q000378:metabolism; D005839:Gentamicins / Q000737:chemistry / Q000494:pharmacology; D020723:Glucuronic Acid / Q000737:chemistry / Q000378:metabolism; D006603:Hexuronic Acids / Q000737:chemistry / Q000378:metabolism; D020007:Implants, Experimental; D008422:Materials Testing; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012995:Solubility; D013211:Staphylococcus aureus / Q000187:drug effects; D014025:Titanium / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D000464:Alginates; D000497:Alloys; D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D004337:Drug Carriers; D005839:Gentamicins; D006603:Hexuronic Acids; D014867:Water; C031462:titanium alloy (TiAl6V4); D020723:Glucuronic Acid; D005780:Gelatin; D014025:Titanium