title: A mutual regulation between cell-cell adhesion and N-glycosylation: implication of the bisecting GlcNAc for biological functions.
abstract: Changes in oligosaccharide structures are associated with numerous physiological and pathological events. E-cadherin-mediated cell-cell adhesion is believed to be both temporally and spatially regulated during development, and represents a key step in the acquisition of the invasive phenotype for many tumors. Here, we focus mainly on a mutual regulation between E-cadherin-mediated cell-cell adhesion and N-acetylglucosaminyltransferase III (GnT-III) expression, and discuss its implications for biological functions.
authors.affiliation: Division of Regulatory Glycobiology, Tohoku Pharmaceutical University, Sendai Miyagi 981-8558, Japan. jgu@tohoku-pharm.ac.jp
authors.forename: Jianguo
authors.initials: J
authors.lastname: Gu
authors.forename: Yuya
authors.initials: Y
authors.lastname: Sato
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Kariya
authors.forename: Tomoya
authors.initials: T
authors.lastname: Isaji
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Taniguchi
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Fukuda
mesh_terms: D000117:Acetylglucosamine / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D015820:Cadherins / Q000378:metabolism*; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D002448:Cell Adhesion / Q000502:physiology*; D006031:Glycosylation; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017351:N-Acetylglucosaminyltransferases / Q000378:metabolism*
chemical_list: D015820:Cadherins; D017351:N-Acetylglucosaminyltransferases; C054599:beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase; C052254:alpha-1,6-mannosylglycoprotein beta 1,6-N-acetylglucosaminyltransferase; D000117:Acetylglucosamine