title: Tumour location is not an independent prognostic factor for survival following a diagnosis of breast cancer.
abstract: Previous studies of patients with breast cancer have examined tumour location as a prognostic factor for survival with contradictory results. The current population-based study with 356 women examines the effect of tumour location and other important prognostic factors on survival. Univariate analyses indicated that central location (P<0.001), a larger pathological tumour size (P=0.003), number of positive lymph nodes (P<0.001), younger age at diagnosis (P=0.003), a more advanced TNM stage (P<0.001), a higher grade (P=0.016) and histologic type (P=0.011) were associated with a higher risk of breast cancer death. The 10-year survival of women with central location was 33%, compared to 73% for medial and 71% for lateral (P<0.001). However, the differences among tumour locations were markedly reduced after adjustment separately for early (P=0.39) and advanced (P=0.56) TNM stages, which also confirmed the results of multivariate analysis that the location does not influence survival after adjustment for other important clinicopathological characteristics.
authors.affiliation: New South Wales Breast Cancer Institute, University of Sydney, Westmead Hospital, New South Wales, Australia.
authors.forename: Upali W
authors.initials: UW
authors.lastname: Jayasinghe
authors.forename: John
authors.initials: J
authors.lastname: Boyages
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000401:mortality* / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000401:mortality / Q000473:pathology; D018275:Carcinoma, Lobular / Q000401:mortality* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D016019:Survival Analysis