title: Protective and therapeutic effects of glyprolines in psychoemotional stress induced by cholecystokinin-4 injection.
abstract: Experiments on outbred albino male rats showed that psychoemotional stress induced by intraperitoneal injection of cholecystokinin-4 (100 microg/kg) increased anxiety, impaired orientation and exploration activities in the elevated plus-maze and hole-board tests, and increased the level of depression of Porsolt test. Preliminary intranasal administration of glyprolines (15 min before cholecystokinin) in a dose of 3.7 micromol/kg prevented the development of stress-induced behavioral disturbances. Administration of peptides 30 min after cholecystokinin-4, i.e., to rats with developed behavioral disturbances, almost completely abolished these disturbances.
authors.affiliation: Department of Human and Animal Physiology, Biological Faculty of M. V. Lomonosov Moscow State University. edeeva_saglara@mail.ru
authors.forename: S E
authors.initials: SE
authors.lastname: Edeeva
authors.forename: G N
authors.initials: GN
authors.lastname: Kopylova
authors.forename: Z V
authors.initials: ZV
authors.lastname: Bakaeva
authors.forename: G E
authors.initials: GE
authors.lastname: Samona
authors.forename: B A
authors.initials: BA
authors.lastname: Umarova
authors.forename: A A
authors.initials: AA
authors.lastname: Guseva
mesh_terms: D000818:Animals; D001007:Anxiety / Q000139:chemically induced / Q000188:drug therapy; D001522:Behavior, Animal / Q000187:drug effects; D003863:Depression / Q000139:chemically induced; D004151:Dipeptides / Q000627:therapeutic use*; D005106:Exploratory Behavior / Q000187:drug effects; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D009842:Oligopeptides / Q000627:therapeutic use*; D011392:Proline / Q000031:analogs & derivatives* / Q000627:therapeutic use; D051381:Rats; D013315:Stress, Psychological / Q000139:chemically induced / Q000188:drug therapy*; D013758:Tetragastrin
chemical_list: D004151:Dipeptides; D009842:Oligopeptides; C113164:prolyl-glycyl-proline; D013758:Tetragastrin; C015248:glycylproline; D011392:Proline