title: [Case of interstitial pneumonia induced by intravesical administration of Bacillus Calmette-Guerin].
abstract: An 81-year-old man with superficial bladder cancer, which was detected after he complained of hematuria and pain on urination, was treated 5 times with intravesical bacillus Calmette-Guerin (BCG) administration. Since he complained of a dry cough and dyspnea associated with severe hypoxemia, and had extensive bilateral pulmonary infiltrative shadows on his chest X-ray film, he was admitted to our hospital. He was treated with methylprednisolone under a diagnosis of interstitial pneumonia. Because BCG infection and/or bacterial pneumonia could not be denied, we administered antituberculosis agent and antibiotics. However, he died due to respiratory failure on 10th day after admission. Because a lymphocyte stimulation test for BCG was strongly positive, we established a diagnosis of interstitial pneumonia induced by intravesical administration of BCG. Because the mortality rate is high, the evaluation of interstitial pneumonia before administration of BCG is crucial.
authors.affiliation: Tobu Chiiki Hospital.
authors.forename: Akihito
authors.initials: A
authors.lastname: Yamamoto
authors.forename: Ryo
authors.initials: R
authors.lastname: Koyama
authors.forename: Kenji
authors.initials: K
authors.lastname: Kido
authors.forename: Kengo
authors.initials: K
authors.lastname: Koike
authors.forename: Michie
authors.initials: M
authors.lastname: Toba
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D000283:Administration, Intravesical; D000369:Aged, 80 and over; D001500:BCG Vaccine / Q000008:administration & dosage* / Q000009:adverse effects*; D017809:Fatal Outcome; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000209:etiology*; D008297:Male; D012131:Respiratory Insufficiency / Q000209:etiology; D001749:Urinary Bladder Neoplasms / Q000628:therapy*
chemical_list: D001500:BCG Vaccine