title: The risk of transmission of Crimean-Congo hemorrhagic fever virus from human cases to first-degree relatives.
abstract: To determine the infectivity of Crimean-Congo hemorrhagic fever (CCHF) virus via routine contacts between serologically confirmed cases and their close relatives from May 2005 up to March 2006, 79 serum samples of 57 close relatives of 12 newly diagnosed serologically confirmed CCHF cases in the Sistan-va-Baluchestan province of Iran were tested for IgG and IgM antibodies against CCHF virus using the enzyme-linked immunosorbent assay technique. Nine levels of contacts were considered: percutaneous contact with the patient's blood, cutaneous contact with the patient's blood, cutaneous contact with non-sanguineous body fluids, cutaneous contact with the patient's skin, sexual contact, eating at the same table, being a roommate of the patient, being a housemate of the patient, and living with the patient in the same building. Only one out of 57 relatives was positive for anti-CCHF IgG (1.8%, 95% confidence interval 0.0 to 9.8%). Thus, the infectivity of the virus via usual routine contacts with patients appears to be low.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Zahedan University of Medical Sciences, Chabahar International Branch, Chabahar, Iran. izadish@yahoo.com
authors.forename: Shahrokh
authors.initials: S
authors.lastname: Izadi
authors.forename: Masoud
authors.initials: M
authors.lastname: Salehi
authors.forename: Kourosh
authors.initials: K
authors.lastname: Holakouie-Naieni
authors.forename: Sadegh
authors.initials: S
authors.lastname: Chinikar
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D016358:Contact Tracing; D004797:Enzyme-Linked Immunosorbent Assay; D005190:Family; D005260:Female; D003225:Hemorrhagic Fever Virus, Crimean-Congo / Q000276:immunology*; D006479:Hemorrhagic Fever, Crimean / Q000635:transmission* / Q000821:virology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007223:Infant; D007492:Iran; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M