Mouse models: the ketogenic diet and polyunsaturated fatty acids.
Literature on the anticonvulsant effects of the ketogenic diet (KD) in mouse seizure models is summarized. Recent data show that a KD balanced in vitamin, mineral, and antioxidant content is anticonvulsant in mice, confirming that the KD's effect in mice can be attributed to the composition of the diet and not other dietary factors. Given that the anticonvulsant mechanism of the KD is still unknown, the anticonvulsant profile of the diet in different seizure models may help to decipher this mechanism. The implications of the findings that the KD is anticonvulsant in electrical seizure models are indicated. Further, the potential involvement of polyunsaturated fatty acids (PUFA) in the KD's anticonvulsant mechanism is discussed.
Borges
Karin
K
Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, USA. Karin.borges@ttuhsc.edu
D000818:Animals; D055423:Diet, Ketogenic; D004195:Disease Models, Animal; D004827:Epilepsy / Q000178:diet therapy*; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D051379:Mice
D005231:Fatty Acids, Unsaturated