Killer granzyme B linked to N-myc- and c-myc-dependent HSC survival: isn't that comyc?
c-myc is a key regulator of hemopoietic stem cell (HSC) activity. In this issue of Cell Stem Cell, Laurenti et al. (2008) show that c-myc and N-myc control HSC survival and link this finding to the regulation of granzyme B expression.
Sauvageau
Guy
G
Laboratory of Molecular Genetics of Stem Cells, Institute for Research in Immunology and Cancer (IRIC), C.P. 6128 succursale Centre-Ville, Montréal, Québec H3C 3J7, Canada. guy.sauvageau@umontreal.ca
Perreault
Claude
C
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D002470:Cell Survival / Q000235:genetics; D015971:Gene Expression Regulation, Enzymologic / Q000235:genetics*; D053804:Granzymes / Q000235:genetics / Q000378:metabolism*; D006410:Hematopoiesis / Q000235:genetics; D006412:Hematopoietic Stem Cells / Q000201:enzymology*; D051379:Mice; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics / Q000378:metabolism*; D022142:Secretory Vesicles / Q000201:enzymology / Q000378:metabolism
D016271:Proto-Oncogene Proteins c-myc; D053804:Granzymes