title: Microbial oxidation of anabolic steroids.
abstract: Microbial transformation of two anabolic steroids, ethylestrenol (1) and nandrolone (2), were carried out. Ethylestrenol (1), when incubated with Rhizopus stolonifer (TSY 0471), yielded two oxidative metabolites named 17alpha-ethyl-3beta,17beta-dihydroxy-19-norndrost-4-ene (3) and 17alpha-ethyl-17beta-hydroxy-19-norandrost-4-en-3-one (4), while incubation of compound 2 with the same fungus yielded two oxidative metabolites, 19-norandrost-4-en-3,17-dione (5) and 6alpha,17beta-dihydroxy-19-norandrost-1,4-dien-3-one (6).
authors.affiliation: H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan. hej@cyber.net.pk
authors.forename: M
authors.initials: M
authors.lastname: Iqbal Choudhary
authors.forename: S
authors.initials: S
authors.lastname: Adnan
authors.forename: A
authors.initials: A
authors.lastname: Shah
authors.lastname: Atta-Ur-Rahman
mesh_terms: D045930:Anabolic Agents / Q000378:metabolism*; D000737:Androstenols / Q000737:chemistry / Q000302:isolation & purification*; D001711:Biotransformation; D005032:Ethylestrenol / Q000378:metabolism*; D008655:Mesterolone / Q000378:metabolism; D015394:Molecular Structure; D009277:Nandrolone / Q000378:metabolism*; D010084:Oxidation-Reduction; D012233:Rhizopus / Q000378:metabolism
chemical_list: D045930:Anabolic Agents; D000737:Androstenols; D008655:Mesterolone; D009277:Nandrolone; D005032:Ethylestrenol