title: Lack of association between interleukin 23 receptor gene polymorphisms and rheumatoid arthritis susceptibility.
abstract: The recent discovery of interleukin 23 (IL-23), its receptor, and the underlying signal transduction pathway has improved our understanding of cellular immunity. Several studies suggest that IL-23 is an essential promoter of chronic joint inflammation. In this report, we assess the possible association of interleukin 23 receptor (IL23R) polymorphisms and haplotypes with rheumatoid arthritis (RA). The study was conducted on 1,204 RA patients and 979 healthy controls. Seven polymorphisms were selected from previous IBD reports. The seven SNPs (rs1004819, rs7517847, rs10489629, rs2201841, rs1343151, rs11209032 and rs1495965) were genotyped using the TaqMan assay. Comparison of RA and control subjects revealed no statistically significant differences in the distribution of the IL23R genotypes and haplotypes. Our results clearly indicate that IL23R gene polymorphisms do not play a significant role in susceptibility to RA in the Korean population. Accordingly, we conclude that IL23R gene polymorphisms cannot be applied as an effective genetic marker for RA susceptibility.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Hanyang University College of Medicine, The Hospital for Rheumatic Diseases, Hanyang University, 17 Haengdang-Dong, Seongdong-Gu, Seoul, 133-792, South Korea.
authors.forename: Jeong Ha
authors.initials: JH
authors.lastname: Park
authors.forename: Yun Jung
authors.initials: YJ
authors.lastname: Kim
authors.forename: Byung Lae
authors.initials: BL
authors.lastname: Park
authors.forename: Joon Seol
authors.initials: JS
authors.lastname: Bae
authors.forename: Hyoung Doo
authors.initials: HD
authors.lastname: Shin
authors.forename: Sang-Cheol
authors.initials: SC
authors.lastname: Bae
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D044466:Asian People; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D053759:Interleukin-23 / Q000378:metabolism; D007596:Joints / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D007723:Korea; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D018123:Receptors, Interleukin / Q000235:genetics*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D005819:Genetic Markers; C515500:IL23R protein, human; D053759:Interleukin-23; D018123:Receptors, Interleukin