title: Fudosteine effects on mucin production.
abstract: BACKGROUND
  Many chronic respiratory conditions are associated with mucin hypersecretion induced by underlying inflammation.
  
  
  OBJECTIVE
  To analyse the results of a preclinical study assessing the pathogenic mechanisms of mucin hyperproduction and the consequent in vivo and in vitro effects of fudosteine, a mucoactive agent.
  
  
  RESULTS
  Both LPS and TNF-alpha increased MUC5AC mucin production in vivo and in vitro, respectively, and fudosteine was found to reduce it by partially interfering with the kinase-mediated inflammation pathway that activates the MUC5AC gene.
  
  
  CONCLUSIONS
  Further preclinical testing in animal models with chronic airways inflammation is necessary.
authors.affiliation: University of Medicine and Pharmacy Gr T Popa Iasi, Division of Pulmonary Disease, Pulmonary Disease University Hospital, Iasi, RO 700115, Romania. sabina.antonela.antoniu@pneum.umfiasi.ro
authors.forename: Sabina
authors.initials: S
authors.lastname: Antonela Antoniu