Chromosomal localization of 13 candidate genes for human obesity in the pig genome.
Thirteen candidate genes for human obesity were selected for cytogenetic mapping by FISH in the pig genome. Among them, 6 genes were assigned to chromosomes for the first time (NR3C1, GNB3, ADRB1, ADRB2, ADRB3 and UCP1). Location of the other 7 genes (INSIG2, LIPIN1, PLIN, NAMPT, ADIPOQ, UCP2 and UCP3), earlier mapped by somatic cell hybridization or with the use of a radiation hybrid panel, was verified (INSIG2) or more precisely described. The genes were assigned to the following chromosomes: INSIG2 to SSC15q12, LIPIN1 to SSC3q26, NR3C1 to SSC2q29, PLIN to SSC7q15, GNB3 to SSC5q21, NAMPT to SSC9q23, ADIPOQ to SSC13q41, ADRB1 to SSC14q28, ADRB2 to SSC2q29, ADRB3 to SSC15q13-14, UCP1 to SSC8q21-22, and both UCP2 and UCP3 to SSC9p24. Most of the genes were located within known QTL for pig fatness traits.
Nowacka-Woszuk
Joanna
J
Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Poznań, Poland.
Szczerbal
Izabela
I
Fijak-Nowak
Honorata
H
Switonski
Marek
M
D000818:Animals; D002874:Chromosome Mapping; D004734:Energy Metabolism; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D050356:Lipid Metabolism / Q000235:genetics; D009765:Obesity / Q000235:genetics; D040641:Quantitative Trait Loci; D034421:Sus scrofa / Q000235:genetics*