title: Effect of different doses of hexavalent chromium on mandibular growth and tooth eruption in juvenile Wistar rats.
abstract: Not only workers employed at industrial plants are exposed to intoxication with the element they manipulate, the population at large is also at risk of suffering health problems caused by contaminating wastes inadequately treated for their safe disposal. As a result certain toxic substances, such as hexavalent chromium,has reached the general population including children. The present study sought to evaluate the effect of intoxication with hexavalent chromium on body and mandibular growth and tooth eruption in suckling Wistar rats. Potassium dichromate was administered by gavage in a dose of 6.25 or 12.5mg/kg body weight (b.w.) to one of the two groups of 4-day-old Wistar rats during 10 days. Our results showed that the effects of chromium are dose-dependent. Morphometric studies of body growth showed lower body weight in both experimental groups and shorter tail length in animals receiving 12.5mg/kg b.w. dose of chromium, compared with controls. All parameters of mandibular growth were lower in the experimental group receiving 12.5mg/kg b.w. of chromium. Differences in tooth eruption were observed at the level of the first molar in animals receiving 12.5mg/kg and of the second molar in those receiving 6.25mg/kg b.w. of chromium. Chromium was found to affect all the studied parameters.
authors.affiliation: Department of Histology and Embryology, School of Dentistry, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: Romina C
authors.initials: RC
authors.lastname: De Lucca
authors.forename: Patricio L
authors.initials: PL
authors.lastname: Dutrey
authors.forename: Mariano E
authors.initials: ME
authors.lastname: Villarino
authors.forename: Angela M
authors.initials: AM
authors.lastname: Ubios
mesh_terms: D000818:Animals; D000833:Animals, Suckling; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004785:Environmental Pollutants / Q000633:toxicity*; D008334:Mandible / Q000187:drug effects* / Q000254:growth & development*; D011192:Potassium Dichromate / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D014078:Tooth Eruption / Q000187:drug effects*
chemical_list: D004785:Environmental Pollutants; D011192:Potassium Dichromate