title: [Development of nanohydroxyapatite composites as bone grafting materials].
abstract: Hydroxyapatite (HA) is one of ideal materials for bone substitutions due to its intrinsic biocompatibility. However, its relatively poor mechanical properties such as brittleness and low strength have hindered its use in high-load applications. Biotic bones themselves are nanocomposites mainly composed of nanohydroxyapatite (n-HA) and collagen. From biomimetic point of view, nanocomposites of HA could potentially improve both biocompatibility and mechanical properties of bone grafting materials. Recent progress in this field branched into nanocomposites of HA with nonbiodegradable and biodegradable polymers, the latter including collagen, gelatin, chitosan, polylactides as well as polyanhydrides. In this paper, the preparation, biological reactions and mechanical properties of different nanocomposites are reviewed in detail.
authors.affiliation: College of Polymer Science and Engineering, Sichuan Universtiy, Chengdu 610065, China.
authors.forename: Ruifang
authors.initials: R
authors.lastname: Wang
authors.forename: Da
authors.initials: D
authors.lastname: Wen
authors.forename: Xingyi
authors.initials: X
authors.lastname: Xie
authors.forename: Yinping
authors.initials: Y
authors.lastname: Zhong
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D018786:Bone Substitutes / Q000138:chemical synthesis* / Q000737:chemistry; D017886:Durapatite / Q000737:chemistry*; D006801:Humans; D053761:Nanocomposites / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry; D010316:Particle Size
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D017886:Durapatite