title: Improved synthesis of polyfluorinated L-lysine for 19F NMR-based screening.
abstract: Polyfluorinated N-alpha-Fmoc-is an element of-Boc-L-lysine represents the best-in-class among a set of polyfluorinated amino acids (PFAs) which are useful tools for (19)F NMR-Based Screening. In this communication, optimized reaction conditions that allowed for the multi-gram preparation of this unnatural amino acid are reported.
authors.affiliation: Department of Chemistry, BU-Oncology, Nerviano Medical Sciences, Viale Pasteur 10, Nerviano, MI, 20014, Italy. beatrice.malgesini@nervianoms.com
authors.forename: Beatrice
authors.initials: B
authors.lastname: Malgesini
authors.forename: Eduard
authors.initials: E
authors.lastname: Felder
authors.forename: Nicola
authors.initials: N
authors.lastname: Mongelli
authors.forename: Gianluca
authors.initials: G
authors.lastname: Papeo
mesh_terms: D005461:Fluorine / Q000737:chemistry*; D007554:Isotopes; D008239:Lysine / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008956:Models, Chemical; D015394:Molecular Structure
chemical_list: D007554:Isotopes; D005461:Fluorine; D008239:Lysine