Genetic polymorphisms of transforming growth factor-beta1 and its receptors and colorectal cancer susceptibility: a population-based case-control study in China.
The TGF-beta signaling pathway plays a very important role in the control of cell proliferation and differentiation that is involved in colorectal carcinogenesis. The associations between polymorphisms of TGF-beta1 and its receptors genes and the colorectal cancer risk were assessed in a population-based case-control study (206 cases and 838 controls). We could not observe any variant in the G-800A, codon25 and codon263 of TGF-beta1 and A-364G of TGFbetaR2 in Chinese population. However, the results revealed that -509CT and TT genotypes were significantly associated with decrease risk for colorectal cancer (adjusted OR=0.58, 95% CI 0.40-0.84 and adjusted OR=0.44, 95% CI 0.29-0.68, respectively). Moreover, the linkage disequilibrium analysis revealed that TGF-beta1 C-509T and codon10 polymorphisms were in strong linkage disequilibrium, and the -509C/+29C was associated with a significantly increased risk of colorectal cancer (OR=1.32, 95% CI=1.05-1.66). Our findings indicate that the distributions of polymorphisms in TGF-beta1 and its receptors genes vary greatly among different ethnic groups, and these polymorphisms might contribute to the colorectal cancer susceptibility.
Zhang
Yongjing
Y
Department of Epidemiology and Health Statistics, Zhejiang University, School of Medicine, 388 Yuhang Tang Road, Hangzhou, Zhejiang 310058, China.
Liu
Bing
B
Jin
Mingjuan
M
Ni
Qin
Q
Liang
Xia
X
Ma
Xinyuan
X
Yao
Kaiyan
K
Li
Qilong
Q
Chen
Kun
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002681:China; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000208:ethnology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism; D053773:Transforming Growth Factor beta1 / Q000378:metabolism*
D018125:Receptors, Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1