Hyper IgE (Job's) syndrome: a primary immune deficiency with oral manifestations.
Autosomal dominant hyper IgE (HIES or Job's) syndrome is a rare primary immune deficiency characterized by eczema, recurrent skin and lung infections, extremely elevated serum IgE, and a variety of connective tissue and skeletal abnormalities. Individuals with HIES share a characteristic facial appearance and many oral manifestations including retained primary dentition, a high arched palate, variations of the oral mucosa and gingiva, and recurrent oral candidiasis. Mutations in STAT3 account for the majority, if not all, of the cases of autosomal dominant HIES, but the pathogenesis of the many varied features remains poorly understood. In this review, we discuss the clinical phenotype of HIES including immunologic and non-immunologic features, the genetics of HIES, and treatment.
Freeman
A F
AF
Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Domingo
D L
DL
Holland
S M
SM
D002180:Candidiasis, Oral / Q000276:immunology; D019066:Facies; D005882:Gingival Diseases / Q000276:immunology; D006801:Humans; D007589:Job Syndrome / Q000235:genetics / Q000276:immunology*; D009059:Mouth Diseases / Q000276:immunology*; D009061:Mouth Mucosa / Q000473:pathology; D009154:Mutation / Q000235:genetics; D010159:Palate / Q000473:pathology; D010641:Phenotype; D012008:Recurrence; D050796:STAT3 Transcription Factor / Q000235:genetics; D014076:Tooth Diseases / Q000276:immunology*; D014094:Tooth, Deciduous / Q000473:pathology
D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human