The stability of choline ascorbate.
The stability of choline ascorbate was studied considering concentration, temperature, and pH of the drug solution. Our results revealed that choline ascorbate is almost fully stable with respect to these parameters. Practically no loss was observed when 3 x l0(-1) (50%) drug solution is preserved in the refrigerator, at ambient temperature, or at 37 degrees C for one year, a finding that favors the high stability of this compound. Choline ascorbate was also found to be more stable in comparison to vitamin C and crystalline ascorbic acid. Its dilution within a vitamin B solution did not modify the amount of ascorbic acid within 120 min at ambient temperature. We conclude that the choline ascorbate form of ascorbic acid appears to be more reliable and promising when the quality of therapy with this agent is concerned.
Yillar
D O
DO
University of Istanbul, Cerrahpaşa Medical Faculty, Department of Pharmacology and Clinical Pharmacology, 34303 Istanbul, Turkey. oyillar@istanbul.edu.tr
Akcasu
A
A
Akkan
G
G
Küçkhüseyin
C
C
D001205:Ascorbic Acid / Q000737:chemistry*; D002794:Choline / Q000737:chemistry*; D004338:Drug Combinations; D004355:Drug Stability; D004356:Drug Storage; D006863:Hydrogen-Ion Concentration; D013696:Temperature; D014815:Vitamins / Q000737:chemistry*
D004338:Drug Combinations; D014815:Vitamins; D002794:Choline; D001205:Ascorbic Acid