Reaction of bone marrow hematopoiesis to the toxic effect of paclitaxel.
Intraperitoneal injection of paclitaxel (Mitotax) in a single dose of 40 mg/kg was followed by an increase in the number of mitotic granulocytic and erythroid cells, hypoplasia, and pancytopenia of the bone marrow in CBA/CaLac mice. The test preparation decreased the number of hematopoietic precursor cells for erythropoiesis and granulocytopoiesis, but increased the count of polyploid cells and incidence of structural and genomic abnormalities in bone marrow cells. These changes were reversible.
Churin
A A
AA
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences. toxicol@sibmail.com
Gol'dberg
V E
VE
Karpova
G V
GV
Voronova
O L
OL
Feodorova
E P
EP
Kolotova
O V
OV
Skurikhin
E G
EG
Pershina
O V
OV
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D001854:Bone Marrow Cells / Q000187:drug effects / Q000502:physiology; D006410:Hematopoiesis / Q000187:drug effects*; D051379:Mice; D008808:Mice, Inbred CBA; D017239:Paclitaxel / Q000494:pharmacology*; D013234:Stem Cells / Q000187:drug effects
D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel