Low-grade gingival leiomyosarcoma in a child.
Leiomyosarcoma (LMS) of the oral cavity, a rare mesenchymal tumor exhibiting smooth-muscle differentiation, is extremely uncommon in childhood. The most frequent location of childhood LMS is the gastrointestinal tract, particularly the stomach. The purpose of this paper is to report a case of leiomyosarcoma affecting the gingival tissues and mandible of a 9-year-old girl with peculiar clinical, microscopic, and radiographic features. Clinical and radiographical examinations revealed a gingival growth affecting the primary mandibular right first molar with inflammatory features. The lesion was initially suspected to be pyogenic granuloma and was removed by excisional biopsy. Microscopic findings showed a hypercellular proliferation of mesenchymal spindle cells, suggesting malignant spindle cell neoplasm. Immunohistochemical, histochemical, and radiographic studies were undertaken, and the final diagnosis established was a low-grade leiomyosarcoma in the gingiva.
Mendonça
Elismauro Francisco
EF
Department of Stomatology (Oral Pathology), Dental School, Federal University of Goiás, Goiânia, Brazil. elismaur@odonto.ufg.br
Martins da Silva
Clóvis
C
Meneghini
Alexandre João
AJ
Silva
Geisa B L
GB
Filho
João Alves A
JA
Batista
Aline Carvalho
AC
D000199:Actins / Q000032:analysis; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D005887:Gingival Neoplasms / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D007890:Leiomyosarcoma / Q000737:chemistry / Q000473:pathology*; D008339:Mandibular Neoplasms / Q000737:chemistry / Q000473:pathology*
D000199:Actins