title: Influences of a dietary supplement in combination with an exercise and diet regimen on adipocytokines and adiposity in women who are overweight.
abstract: The influence of a proprietary blend of modified cellulose and cetylated fatty acids (Trisynextrade mark, Imagenetix, Inc., San Diego, CA 92127, USA) on adipocytokine and regional body composition responses to a weight loss program was examined. Twenty-two women (Supplement group (S) (n = 11): age = 36.8 +/- 7.2 years; weight = 87.1 +/- 6.2 kg; % body fat = 43.4 +/- 4.1; Placebo group (P) (n = 11): age = 38.3 +/- 6.8 years; weight = 86.9 +/- 4.7 kg; % body fat = 44.3 +/- 2.0) completed an 8-week placebo-controlled, double-blind study consisting of a caloric restricted diet and cardiovascular exercise. Body composition and serum insulin, leptin, and adiponectin were assessed at pre-, mid-, and post-intervention. From pre- to post-intervention, significant decreases (P < 0.05) were observed for body weight (S: 87.1 +/- 6.2-77.9 +/- 5.1 kg; P: 86.9 +/- 4.7-82.7 +/- 3.8 kg) (P < 0.05 S vs. P), % body fat (S: 43.4 +/- 4.1-36.1 +/- 3.6; P: 44.3 +/- 2.0-40.6 +/- 1.2) (P < 0.05 S vs. P), leptin (S: 28.3 +/- 3.5-16.2 +/- 2.6 ng ml(-1); P: 29.4 +/- 3.2-19.9 +/- 1.1 ng ml(-1)) (P < 0.05 S vs. P), and insulin (S: 7.3 +/- 0.8-5.1 +/- 0.2 mU l(-1); P: 7.7 +/- 0.9-5.1 +/- 0.3 mU l(-1)). Serum adiponectin increased (P < 0.05) (S: 12.2 +/- 2.4-26.3 +/- 3.0 microg ml(-1): 12.6 +/- 2.0-21.8 +/- 3.1 microg ml(-1)) (P < 0.05 for S vs. P). Supplementation with a proprietary blend of modified cellulose and cetylated fatty acids during an 8-week weight loss program exhibited favorable effects on adipocytokines and regional body composition.
authors.affiliation: Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs, CT, 06269, USA.
authors.forename: Maren S
authors.initials: MS
authors.lastname: Fragala
authors.forename: William J
authors.initials: WJ
authors.lastname: Kraemer
authors.forename: Jeff S
authors.initials: JS
authors.lastname: Volek
authors.forename: Carl M
authors.initials: CM
authors.lastname: Maresh
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Puglisi
authors.forename: Jakob L
authors.initials: JL
authors.lastname: Vingren
authors.forename: Jen-Yu
authors.initials: JY
authors.lastname: Ho
authors.forename: Disa L
authors.initials: DL
authors.lastname: Hatfield
authors.forename: Barry A
authors.initials: BA
authors.lastname: Spiering
authors.forename: Cassandra E
authors.initials: CE
authors.lastname: Forsythe
authors.forename: Gwendolyn A
authors.initials: GA
authors.lastname: Thomas
authors.forename: Erin E
authors.initials: EE
authors.lastname: Quann
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Anderson
authors.forename: Robert L
authors.initials: RL
authors.lastname: Hesslink
mesh_terms: D054392:Adipokines / Q000097:blood*; D050154:Adiposity / Q000502:physiology*; D000328:Adult; D001823:Body Composition / Q000502:physiology; D002482:Cellulose / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D019587:Dietary Supplements; D004311:Double-Blind Method; D005081:Exercise Therapy; D005227:Fatty Acids / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D009765:Obesity / Q000628:therapy; D050177:Overweight / Q000097:blood / Q000178:diet therapy / Q000628:therapy*
chemical_list: D054392:Adipokines; D005227:Fatty Acids; C540305:Trisynex; D002482:Cellulose