Solubilisation of griseofulvin in aqueous micellar solutions of diblock copolymers of ethylene oxide and 1,2-butylene oxide with lengthy B-blocks.
The influence of hydrophobic-block length on solubilisation capacity was examined for micelles of E(m)B(n) copolymers (E=oxyethylene, B=oxybutylene, subscripts denote number-average block lengths in repeat units) with B-block lengths in the range of 30-76 and with E-blocks of sufficient length to ensure the formation of spherical micelles. Griseofulvin was used as a model poorly-water-soluble drug known to be almost exclusively solubilised in the micellar core. Combination of solubilisation data with those of a previous study has shown that the amount of drug solubilised per gram of hydrophobe is essentially independent of B-block length when this exceeds about 15 B units, suggesting that core size is not a major influence on solubilisation.
Ribeiro
Maria Elenir N P
ME
Department of Organic and Inorganic Chemistry, Polymer Laboratory, Federal University of Ceará, CX 12.200, CEP 60455-760, Fortaleza, Ceará, Brazil.
Cavalcante
Igor Marques
IM
Ricardo
Nágila M P S
NM
Mai
Shao-Min
SM
Attwood
David
D
Yeates
Stephen G
SG
Booth
Colin
C
D004852:Epoxy Compounds / Q000737:chemistry*; D005027:Ethylene Oxide / Q000737:chemistry*; D006118:Griseofulvin / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008823:Micelles; D011108:Polymers / Q000737:chemistry; D012995:Solubility
D004852:Epoxy Compounds; D008823:Micelles; D011108:Polymers; C027488:1,2-epoxybutane; D006118:Griseofulvin; D005027:Ethylene Oxide