Proteases and bone remodelling.
Bone remodelling is regulated by osteogenic cells which act individually through cellular and molecular interaction. These interactions can be established either through a cell-cell contact, involving molecules of the integrin family, or by the release of many polypeptidic factors and/or their soluble receptor chains. Proteolytic shedding of membrane-associated proteins regulates the physiological activity of numerous proteins. Proteases located on the plasma membrane, either as transmembrane proteins or anchored to cell-surface molecules, serve as activators or inhibitors of different cellular and physiological processes. This review will focus on the role of the proteases implicated in bone remodelling either through the proteolytic degradation of the extracellular matrix or through their relations with osteogenic factors. Their implication in bone tumor progression will be also considered.
Georges
S
S
Université de Nantes, Nantes Atlantique Universités, France.
Ruiz Velasco
C
C
Trichet
V
V
Fortun
Y
Y
Heymann
D
D
Padrines
M
M
D000818:Animals; D001857:Bone Matrix / Q000378:metabolism; D001859:Bone Neoplasms / Q000378:metabolism* / Q000473:pathology; D016723:Bone Remodeling; D056657:Cathepsin K; D002403:Cathepsins / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D018450:Disease Progression; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D045726:Metalloproteases / Q000378:metabolism; D008954:Models, Biological; D010447:Peptide Hydrolases / Q000502:physiology*
D016207:Cytokines; D016023:Integrins; D036341:Intercellular Signaling Peptides and Proteins; D002403:Cathepsins; D045726:Metalloproteases; D010447:Peptide Hydrolases; C534130:CTSK protein, human; D056657:Cathepsin K