title: Prevalence and significance of hypoalbuminemia in an internal medicine department.
abstract: BACKGROUND
  Serum albumin is commonly measured in hospitalized patients. It has habitually been included among the parameters used for nutritional assessment, and recently its use has become even more widespread. Yet, no data are available in the literature about the prevalence and clinical significance of hypoalbuminemia in patients hospitalized in an internal medicine ward. The aim of this study was to investigate the prevalence and clinical significance of hypoalbuminemia in in-hospital internal medicine patients.
  
  
  METHODS
  We retrospectively evaluated the albumin level of patients admitted to the Department of Internal Medicine and Biomedical Sciences of the University of Parma during the year 2000. We then evaluated sex, age, nutritional status, some laboratory parameters, associated diseases, and length of hospitalization in hypoalbuminemic patients in comparison with a group of patients without hypoalbuminemia.
  
  
  RESULTS
  Hypoalbuminemics (46.5% of patients) were older, more frequently anemic, and had a higher erythrocyte sedimentation rate (ESR) and longer hospitalization; they were mostly normal weight or overweight. These patients also had chronic liver (18.6% vs. 4.5%), onco-hematological (33.8% vs. 12%), and infectious diseases (13.4% vs. 2.3%) and nephropathies (6.3% vs. 2%) more often than patients without hypoalbuminemia. The presence of onco-hematological diseases was related to anemia (O.R.=5.73; 95% CI: 3.184-10.310), lymphopenia (O.R.=2.76; 95% CI: 1.584-4.801), and hypoalbuminemia (O.R.=2.5; 95% CI: 1.178-5.307).
  
  
  CONCLUSIONS
  Hypoalbuminemia is very frequent in an internal medicine ward. In this setting, serum albumin is related to the length of hospitalization and to other parameters with a well-known prognostic value (age, hemoglobin) and clinical usefulness (ESR). It may also play a role in the evaluation of the possible association of onco-hematological diseases.
authors.affiliation: Department of Internal Medicine and Biomedical Sciences of University of Parma, Italy, Via Gramsci 14, 43100, Parma, Italy. ffilo@libero.it
authors.forename: Filippo
authors.initials: F
authors.lastname: Numeroso
authors.forename: Angela L
authors.initials: AL
authors.lastname: Barilli
authors.forename: Roberto
authors.initials: R
authors.lastname: Delsignore
mesh_terms: D000367:Age Factors; D000368:Aged; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006785:Hospitals, University / Q000706:statistics & numerical data*; D006801:Humans; D034141:Hypoalbuminemia / Q000175:diagnosis / Q000453:epidemiology*; D007388:Internal Medicine; D007558:Italy / Q000453:epidemiology; D007902:Length of Stay; D008297:Male; D008499:Medical Records; D015596:Nutrition Assessment; D015995:Prevalence; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index