title: [Association of genetic polymorphisms in selenoprotein GPX1 and TXNRD2 with genetic susceptibility of gastric cancer].
abstract: OBJECTIVE
  This study examined whether the two polymorphisms of GPX1 (198Pro--> Leu) and TXNRD2 (370Lys-->Arg) contributed alone or in combination, to the risk of gastric cancer development.
  
  
  METHODS
  A total of 361 patients with gastric cancer and 363 cancer-free controls were recruited and their genotypes of the two polymorphisms were determined by polymerase chain reaction-based restrictive fragment length polymorphism (PCR-RFLP) method. Odds ratio (OR) and 95% confidence interval (CI) were computed using unconditional logistic regression model.
  
  
  RESULTS
  GPX1 and TXNRD2 polymorphisms individually were not associated with the risk of gastric cancer. Gene-gene interaction of GPX1 and TXNRD2 polymorphisms decreased the risk of gastric cancer. Carrying the protective genotype might decrease the risk at 62% (OR = 0.38, 95% CI = 0.26-0.55, P < 0.001) as compared with the risk genotype.
  
  
  CONCLUSIONS
  The GPX1 198 Pro/Pro and TXNRD2 370Arg/Arg genotypes might be associated with the genetic susceptibility of gastric cancer.
authors.affiliation: Department of Nutrition and Food Hygiene, Peking University Health Science Center, Beijing 100083, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Wang
authors.forename: Tong
authors.initials: T
authors.lastname: Sun
authors.forename: Ming
authors.initials: M
authors.lastname: Yang
authors.forename: Dong-Xin
authors.initials: DX
authors.lastname: Lin
authors.forename: Wen
authors.initials: W
authors.lastname: Tan
authors.forename: Ke-Ji
authors.initials: KJ
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Xiao
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005979:Glutathione Peroxidase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D013274:Stomach Neoplasms / Q000235:genetics*; D054482:Thioredoxin Reductase 2 / Q000235:genetics*; D000094765:Glutathione Peroxidase GPX1
chemical_list: D005979:Glutathione Peroxidase; C516127:TXNRD2 protein, human; D054482:Thioredoxin Reductase 2; D000094765:Glutathione Peroxidase GPX1; C000722067:GPX1 protein, human