[Characterization of rabies virus phosphoprotein in high prevalence provinces of China].
OBJECTIVE
Characterization of rabies virus phosphoprotein through analyzation of genetic variations about rabies virus phosphoproteins in high-incidence regions in China.


METHODS
The nucleotide sequence of the P gene of Guangxi, Guizhou and Hunan provinces positive sample's were sequenced, and the P region's similarity and phylogenetic analyses were completed by using softer wares.


RESULTS
The similarity of P region's nucleotide sequence is 82.1%-100%, while, the similarity of amino acid sequence is 87.5%-100%. A little variation in phosphoprotein cannot influence its biological functions.


CONCLUSIONS
All rabies viruses isolated from Guangxi, Guizhou and Hunan provinces belong to genotype 1 and share same phylogenesis and same genome characteristic; Virus distribution presents unique Characterization; Some virus isolates from Hunan province and Thailand may come from the same virus.
Wang
Xiao-Guang
XG
Department of Viral Encephalitis, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China.
Tao
Xiao-Yan
XY
Li
Hao
H
Song
Miao
M
Du
Jia-Liang
JL
Zhang
Qiang
Q
Mo
Zhao-Jun
ZJ
Zhou
Kai-Jiao
KJ
Zhang
Hong
H
Dai
De-Fang
DF
Wang
Ding-Ming
DM
Zhou
Jin-Zhu
JZ
Tang
Qing
Q
Liang
Guo-Dong
GD
D000818:Animals; D002681:China / Q000453:epidemiology; D004283:Dog Diseases / Q000453:epidemiology / Q000821:virology*; D004285:Dogs; D006801:Humans; D018832:Molecular Chaperones; D008969:Molecular Sequence Data; D010750:Phosphoproteins / Q000235:genetics*; D010802:Phylogeny; D015995:Prevalence; D011818:Rabies / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology*; D011820:Rabies virus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D015678:Viral Structural Proteins / Q000235:genetics*
D018832:Molecular Chaperones; C103961:P phosphoprotein, Rabies virus; D010750:Phosphoproteins; D015678:Viral Structural Proteins