title: Bag-in-the-lens: first pathological analysis of a human eye obtained postmortem.
abstract: We analyzed an enucleated eye obtained postmortem from an 86-year-old donor who had been implanted with a hydrophilic acrylic bag-in-the-lens 4 months earlier. To our knowledge, this is the first donor eye implanted with this design to undergo pathological analysis. High-frequency ultrasound showed a well-centered IOL, fixated at the level of the capsular bag. Gross and light microscopic analyses of the eye showed that if anterior and posterior capsule openings are well stretched around the optic of this IOL design, proliferative/regenerative material is potentially confined to the intercapsular space of the capsular bag remnant outside the optic rim.
authors.affiliation: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah 84132, USA. liliana.werner@hsc.utah.edu
authors.forename: Liliana
authors.initials: L
authors.lastname: Werner
authors.forename: Marie-José
authors.initials: MJ
authors.lastname: Tassignon
authors.forename: Laure
authors.initials: L
authors.lastname: Gobin
authors.forename: Jos
authors.initials: J
authors.lastname: Rozema
authors.forename: Don
authors.initials: D
authors.lastname: Davis
authors.forename: Jacob
authors.initials: J
authors.lastname: Brubaker
mesh_terms: D000369:Aged, 80 and over; D000869:Anterior Eye Segment / Q000000981:diagnostic imaging / Q000473:pathology*; D019923:Capsulorhexis / Q000379:methods*; D015353:Eye Enucleation; D006801:Humans; D007903:Lens Capsule, Crystalline / Q000000981:diagnostic imaging / Q000473:pathology*; D019654:Lens Implantation, Intraocular / Q000379:methods*; D007910:Lenses, Intraocular; D008297:Male; D011474:Prosthesis Design; D014019:Tissue Donors; D014463:Ultrasonography