Possible new antiaging strategies related to neuroendocrine-immune interactions.
The aging process demonstrates gradual and spontaneous changes, resulting in maturation through childhood, puberty and young adulthood, and then decline through middle and late age. However, animals and humans are capable of reaching the extreme limit of life span characteristic for the species with a very efficient network of antiaging mechanisms. Among them, neuroendocrine-immune interactions play a pivotal role. The loss of the capacity of the organism in remodeling the neuroendocrine-immune response leads to the appearance of age-associated pathologies. We herein report some substances which can be proposed as new antiaging strategies because of their capacity to remodel some biological functions in old animals and humans. These substances are: L-deprenyl, leptin, ghrelin, carnosine and NO donors. Their role as possible antiaging strategies in healthy people in relation to neuroendocrine-immune responses and zinc ion bioavailability is reported and discussed.
Mocchegiani
Eugenio
E
Immunology Center (Laboratory of Nutrigenomic and Immunosenescence), Research Department INRCA, Ancona, Italy. e.mocchegiani@inrca.it
Malavolta
Marco
M
D000328:Adult; D000368:Aged; D000375:Aging / Q000187:drug effects* / Q000276:immunology; D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use; D002336:Carnosine / Q000627:therapeutic use; D002675:Child, Preschool; D004285:Dogs; D005260:Female; D054439:Ghrelin / Q000502:physiology; D006801:Humans; D020738:Leptin / Q000502:physiology; D008136:Longevity / Q000187:drug effects; D008297:Male; D015213:Neuroimmunomodulation / Q000187:drug effects / Q000502:physiology*; D020030:Nitric Oxide Donors / Q000627:therapeutic use; D012642:Selegiline / Q000627:therapeutic use; D055815:Young Adult; D015032:Zinc / Q000627:therapeutic use
D016588:Anticarcinogenic Agents; D000975:Antioxidants; D054439:Ghrelin; D020738:Leptin; D020030:Nitric Oxide Donors; D012642:Selegiline; D002336:Carnosine; D015032:Zinc