title: Hyperuricemia and its related factors in an urban population, Izmir, Turkey.
abstract: The aim of this study was to examine the prevalence of hyperuricemia and its associated factors in an urban area of Izmir, located in western Turkey. Our study group was selected by computerized sampling from the participants of a larger population-based study searching for the prevalence of rheumatoid arthritis in Balcova and Narlidere districts of Izmir. A total of 132 subjects (69 women and 63 men) were included in this study. Serum uric acid, glucose, creatinine and lipid levels were studied. Body composition along with body fat percentage was determined anthropometrically. A total of 16 subjects had hyperuricemia (4 women and 12 men). The overall prevalence of hyperuricemia was 12.1% and the mean uric acid level was 4.9 +/- 1.3 mg/dl. Males had significantly higher uric acid levels than females (P < 0.05; 5.5 +/- 1.3 vs. 4.3 +/- 1.1 mg/dl, respectively). The prevalence of hypertension, diabetes, obesity and metabolic syndrome was 24.4, 5.3, 28 and 26.5%, respectively. There was no gouty subject. Sum of skinfold thickness (SFT) measurements and creatinine levels were the independent predictors of hyperuricemia (beta = 0.45, 0.47, respectively). Uric acid measurement is important not only for inflammatory rheumatic disorders but also for predicting metabolic syndrome and related coronary artery disease. There is sex difference in uric acid levels in favor of women most probably explained by gonadal hormones. Hyperuricemia is significantly predicted by anthropometric measure of SFT which is a simple clinical screening method along with creatinine levels.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Dokuz Eylul University School of Medicine, Dokuz Eylul Universitesi Tip Fakultesi, Romatoloji Bilim Dali, Balcova, 35340, Izmir, Turkey. ismailsari35@gmail.com
authors.forename: Ismail
authors.initials: I
authors.lastname: Sari
authors.forename: Servet
authors.initials: S
authors.lastname: Akar
authors.forename: Betul
authors.initials: B
authors.lastname: Pakoz
authors.forename: Ali Riza
authors.initials: AR
authors.lastname: Sisman
authors.forename: Oguz
authors.initials: O
authors.lastname: Gurler
authors.forename: Merih
authors.initials: M
authors.lastname: Birlik
authors.forename: Fatos
authors.initials: F
authors.lastname: Onen
authors.forename: Nurullah
authors.initials: N
authors.lastname: Akkoc
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism; D001823:Body Composition; D003404:Creatinine / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood; D005260:Female; D006073:Gout / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000097:blood; D033461:Hyperuricemia / Q000097:blood / Q000453:epidemiology*; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000453:epidemiology; D008875:Middle Aged; D009765:Obesity / Q000097:blood; D015995:Prevalence; D012044:Regression Analysis; D012737:Sex Factors; D014421:Turkey / Q000453:epidemiology; D014505:Urban Population; D014527:Uric Acid / Q000097:blood
chemical_list: D001786:Blood Glucose; D008055:Lipids; D014527:Uric Acid; D003404:Creatinine