Connective tissue growth factor and cardiac fibrosis.
Cardiac fibrosis is a major pathogenic factor in a variety of cardiovascular diseases and refers to an excessive deposition of extracellular matrix components in the heart, which leads to cardiac dysfunction and eventually overt heart failure. Evidence is accumulating for a crucial role of connective tissue growth factor (CTGF) in fibrotic processes in several tissues including the heart. CTGF orchestrates the actions of important local factors evoking cardiac fibrosis. The central role of CTGF as a matricellular protein modulating the fibrotic process in cardiac remodelling makes it a possible biomarker for cardiac fibrosis and a potential candidate for therapeutic intervention to mitigate fibrosis in the heart.
Daniels
A
A
Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.
van Bilsen
M
M
Goldschmeding
R
R
van der Vusse
G J
GJ
van Nieuwenhoven
F A
FA
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D055513:Connective Tissue Growth Factor / Q000502:physiology*; D003925:Diabetic Angiopathies / Q000378:metabolism; D005355:Fibrosis / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000378:metabolism; D051379:Mice; D017202:Myocardial Ischemia / Q000378:metabolism; D009206:Myocardium / Q000473:pathology*; D015398:Signal Transduction / Q000502:physiology
D015415:Biomarkers; D055513:Connective Tissue Growth Factor