Influence of interleukin-10 gene G-1082A polymorphism on recurrent IgA nephropathy.
BACKGROUND
The G-1082A polymorphism of the interleukin-10 (IL-10) gene has been associated with modified gene expression and the progression of primary IgA nephropathy (IgAN). In the present study, we evaluated its influence on recurrent IgAN after renal transplantation.


METHODS
We studied 103 patients who suffered from IgAN and underwent renal transplantation, followed up for 5.8 -/+ 3.4 years. A cohort of 206 matched renal allograft recipients with other primary diseases was analyzed as a control group. IL-10 gene G-1082A polymorphism was determined by PCR amplification.


RESULTS
Microscopic hematuria and/or proteinuria of more than 500 mg/24 hours occurred in 22 patients (21%). Histological confirmation of IgAN recurrence was obtained in 16 patients. Young recipient age was associated with biopsy-proven IgAN recurrence in the Kaplan-Meier analysis of recurrence-free survival (p=0.05). The presence of IgAN recurrence had no impact on graft survival (not significant [NS]). Furthermore, graft survival was similar in patients with IgAN and patients with other primary diseases (NS). The IL-10 GG genotype was associated with a higher recurrence rate in the Kaplan-Meier analysis of recurrence-free survival (p<0.05).


CONCLUSIONS
IgAN recurrence is a common complication, especially in younger renal transplant recipients. IL-10 gene G-1082A polymorphism was associated with an increased recurrence rate.
Bantis
Christos
C
Department of Nephrology, Heinrich-Heine University, Düsseldorf - Germany.
Heering
Peter J
PJ
Aker
Sendogan
S
Schwandt
Christina
C
Grabensee
Bernd
B
Ivens
Katrin
K
D000328:Adult; D000483:Alleles; D001706:Biopsy; D004247:DNA / Q000235:genetics*; D018572:Disease-Free Survival; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D005922:Glomerulonephritis, IGA / Q000097:blood / Q000235:genetics* / Q000601:surgery; D006085:Graft Survival; D006801:Humans; D016753:Interleukin-10 / Q000097:blood / Q000235:genetics*; D016030:Kidney Transplantation / Q000473:pathology; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors
D016753:Interleukin-10; D004247:DNA