Factors affecting hematopoietic progenitor cell mobilization: an analysis of 307 patients.
We reviewed the data of 307 patients treated with autologous bone marrow transplantation with the aim to identify factors associated with poor hematopoietic stem cell (HSC) mobilization after administration of cyclophosphamide and granulocyte-colony stimulating factor. Success in mobilization was defined when > or = 2.0 x 10(6) CD34+ cells/kg weight could be collected with < or = 3 leukapheresis procedures. Success was observed in 260 patients (84.7%) and nonsuccess in 47 patients (15.3%). According to the stepwise regression model: diagnosis, chemotherapy load, treatment with mitoxantrone and platelet count before mobilization were found to be independent predictive factors for HSC mobilization. These results could help in the previous recognition of patients at risk for non response to mobilization and allow to plan an alternative protocol for this group of patients.
Mendrone
Alfredo
A
Fundação Pró-Sangue/Hemocentro de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 155 - 1 degrees andar, Cerqueira Cesar, São Paulo, SP 05403-000, Brazil. alfredo.mendrone@prosangue.sp.gov.br
Arrais
Cyntia Araujo
CA
Saboya
Rosaura
R
Chamone
Dalton de Alencar Fischer
Dde A
Dulley
Frederico Luiz
FL
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003520:Cyclophosphamide / Q000008:administration & dosage*; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000008:administration & dosage*; D019650:Hematopoietic Stem Cell Mobilization; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D019653:Myeloablative Agonists / Q000008:administration & dosage*; D012307:Risk Factors
D019653:Myeloablative Agonists; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D003520:Cyclophosphamide