title: Therapeutic anticoagulant does not modify thromboses rate vein after venous reconstruction following pancreaticoduodenectomy.
abstract: Recommendations for anticoagulation following major venous reconstruction for pancreatic adenocarcinoma (PA) are not clearly established. The aim of our study was to find out the relation between postoperative anticoagulant treatment and thrombosis rate after portal venous resection. Materials and methods. Between 1986 and 2006, twenty seven portal vein resections were performed associated with pancreaticoduodenectomies (n = 27) (PD).We defined four types of venous resection: type I was performed 1 cm above the confluent of the superior mesenteric vein (SMV) (n = 12); type II lateral resection and venorrhaphy at the level of the confluent SMV (n = 12); type III (n = 1) resulted from a primary end-to-end anastomosis above confluent and PTFE graph was used for reconstruction for type IV (n = 2). Curative anticoagulant treatment was always indicated after type IV (n = 2) resection, and after resection of type II when the length of venous resection was longer than >/=2 cm. Results. Venous thrombosis rate reached: 0%, 41%, and 100% for type I, II, IV resections, respectively. Among them four patients received curative anticoagulant treatment. Conclusion. After a portal vein resection was achieved in the course of a PD, curative postoperative anticoagulation does not prevent efficiently the onset of thrombosis.
authors.affiliation: Service de Chirurgie Digestive et Oncologique, Pôle d'Oncologie et de Spécialité Médicale et Chirurgicale, Hôpital Timone, 13385 Marseille, France. mehdi.ouaissi@mail.ap-hm.fr
authors.forename: Mehdi
authors.initials: M
authors.lastname: Ouaïssi
authors.forename: Igor
authors.initials: I
authors.lastname: Sielezneff
authors.forename: Nicolas
authors.initials: N
authors.lastname: Pirro
authors.forename: Rémi
authors.initials: R
authors.lastname: Bon Mardion
authors.forename: Jean Batiste
authors.initials: JB
authors.lastname: Chaix
authors.forename: Abdelrhame
authors.initials: A
authors.lastname: Merad
authors.forename: Stéphane
authors.initials: S
authors.lastname: Berdah
authors.forename: Vincent
authors.initials: V
authors.lastname: Moutardier
authors.forename: Silvia
authors.initials: S
authors.lastname: Cresti
authors.forename: Olivier
authors.initials: O
authors.lastname: Emungania
authors.forename: Loundou
authors.initials: L
authors.lastname: Anderson
authors.forename: Brunet
authors.initials: B
authors.lastname: Christian
authors.forename: Sastre
authors.initials: S
authors.lastname: Bernard