title: Poststroke depression in patients with small subcortical infarcts.
abstract: OBJECTIVE
  Small subcortical infarcts (SSIs) can result from small vessel disease (SVD) and intracranial and extracranial large artery disease (LAD). No study has explored poststroke depression (PSD) in different etiological types of SSIs.
  
  
  METHODS
  Patients with SSIs resulting from LAD and SVD were included in the study. Poststroke depression was evaluated with the 15-item version of the geriatric depression scale (GDS) 3 months after stroke.
  
  
  RESULTS
  Of the 127 patients with SSIs, 44 had LAD and 83 had SVD. The LAD group had a significantly higher mean GDS score and higher frequency of PSD (p<0.05). The etiological type LAD was a significant independent risk factor for PSD.
  
  
  CONCLUSIONS
  PSD is more common in patients with SSIs resulting from LAD. This suggests that cerebral blood perfusion may play an important role in the development of PSD.
authors.affiliation: Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong, ae, China. davischan78@gmail.com
authors.forename: Yangkun
authors.initials: Y
authors.lastname: Chen
authors.forename: Xiangyan
authors.initials: X
authors.lastname: Chen
authors.forename: Vincent C T
authors.initials: VC
authors.lastname: Mok
authors.forename: Wynnie W M
authors.initials: WW
authors.lastname: Lam
authors.forename: Ka Sing
authors.initials: KS
authors.lastname: Wong
authors.forename: Wai Kwong
authors.initials: WK
authors.lastname: Tang
mesh_terms: D000368:Aged; D001921:Brain / Q000098:blood supply / Q000473:pathology*; D002539:Cerebral Arterial Diseases / Q000150:complications / Q000473:pathology; D002536:Cerebral Arteries / Q000473:pathology; D002544:Cerebral Infarction / Q000150:complications* / Q000473:pathology / Q000523:psychology; D003863:Depression / Q000453:epidemiology* / Q000209:etiology* / Q000523:psychology; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D016015:Logistic Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012044:Regression Analysis; D012307:Risk Factors; D020521:Stroke / Q000150:complications* / Q000523:psychology