Are metabolic factors associated with coronary artery stenosis on MDCT?
BACKGROUND
The association between metabolic syndrome (MetS) and the severity of coronary artery disease (CAD) as determined by multidetector row computed tomography (MDCT) is unclear.


RESULTS
The number of significantly stenosed vessels (VD), coronary artery calcification score, visceral fat area (VFA), subcutaneous fat area (SFA), and abdominal circumference were quantified using MDCT. Plasma levels of metabolic factors were also measured. Plasma levels of adiponectin were negatively correlated with body mass index, diastolic blood pressure, triglycerides, hemoglobin A(1c), fasting glucose, SFA, VFA and waist circumference, and positively correlated with age and high-density lipoprotein-cholesterol (HDL-C). VD in the MetS group was significantly higher than in the non-MetS group. In the 5 groups classified according to the number of metabolic factors, adiponectin was significantly decreased, whereas VD was significantly increased as the number of factors increased. Multivariate logistic regression analysis revealed that the number of VD was most closely correlated with HDL-C (P=0.0014).


CONCLUSIONS
Of the metabolic factors, lower levels of HDL-C may be most useful for predicting CAD independent of other metabolic markers such as adiponectin, VFA or present medication.
Mitsutake
Ryoko
R
Department of Cardiology, Fukuoka University School of Medicine, Jonan-ku, Fukuoka, Japan.
Miura
Shin-ichiro
S
Kawamura
Akira
A
Saku
Keijiro
K
D052242:Adiponectin / Q000097:blood; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D050218:Body Fat Distribution; D008076:Cholesterol, HDL / Q000097:blood; D023921:Coronary Stenosis / Q000000981:diagnostic imaging* / Q000208:ethnology / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007564:Japan; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000000981:diagnostic imaging* / Q000208:ethnology / Q000378:metabolism*; D008875:Middle Aged; D011237:Predictive Value of Tests; D012720:Severity of Illness Index; D036542:Tomography, Spiral Computed / Q000379:methods*; D014280:Triglycerides / Q000097:blood
D052242:Adiponectin; D015415:Biomarkers; D001786:Blood Glucose; D008076:Cholesterol, HDL; D006442:Glycated Hemoglobin; D014280:Triglycerides