title: Antifungal and antibacterial activity of the newly synthesized 2-xanthone derivatives.
abstract: A series of 2-substituted xanthone derivatives 8-20 containing selected allyl, cinnamyl, morpholine, and imidazole moieties were synthesized and tested for their antifungal and antibacterial in-vitro properties. Of the newly synthesized derivatives, ten revealed antifungal activity especially against Trichophyton mentagrophytes (the biggest inhibition zones ranged 35 mm for 11 and 13). 2-(3-(Allylamino)propoxy)-9H-xanthen-9-one hydrochloride 9 inhibited growth of all of the examined fungal species. Significant efficacy against evaluated yeasts and dermatophytes was also observed for 6-chloro-2-methyl-9H-xanthen-9-one derivatives 11-13 containing encyclic amine moieties. Additionally, compounds 9, 11, and 12 hindered development of bacteria species but in a lesser degree. They were efficacious against Staphylococcus aureus, Escherichia coli, and Enterococcus faecalis.
authors.affiliation: Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, Cracow, Poland. hen.mar@interia.pl
authors.forename: Henryk
authors.initials: H
authors.lastname: Marona
authors.forename: Natalia
authors.initials: N
authors.lastname: Szkaradek
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Karczewska
authors.forename: Danuta
authors.initials: D
authors.lastname: Trojanowska
authors.forename: Alicja
authors.initials: A
authors.lastname: Budak
authors.forename: Piotr
authors.initials: P
authors.lastname: Bober
authors.forename: Waldemar
authors.initials: W
authors.lastname: Przepiórka
authors.forename: Marek
authors.initials: M
authors.lastname: Cegla
authors.forename: Edward
authors.initials: E
authors.lastname: Szneler
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003883:Arthrodermataceae / Q000187:drug effects; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D044004:Xanthones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015003:Yeasts / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D044004:Xanthones