title: Genome-scale analyses of health-promoting bacteria: probiogenomics.
abstract: The human body is colonized by an enormous population of bacteria (microbiota) that provides the host with coding capacity and metabolic activities. Among the human gut microbiota are health-promoting indigenous species (probiotic bacteria) that are commonly consumed as live dietary supplements. Recent genomics-based studies (probiogenomics) are starting to provide insights into how probiotic bacteria sense and adapt to the gastrointestinal tract environment. In this Review, we discuss the application of probiogenomics in the elucidation of the molecular basis of probiosis using the well-recognized model probiotic bacteria genera Bifidobacterium and Lactobacillus as examples.
authors.affiliation: Department of Genetics, Anthropology and Evolution, University of Parma, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Ventura
authors.forename: Sarah
authors.initials: S
authors.lastname: O'Flaherty
authors.forename: Marcus J
authors.initials: MJ
authors.lastname: Claesson
authors.forename: Francesca
authors.initials: F
authors.lastname: Turroni
authors.forename: Todd R
authors.initials: TR
authors.lastname: Klaenhammer
authors.forename: Douwe
authors.initials: D
authors.lastname: van Sinderen
authors.forename: Paul W
authors.initials: PW
authors.lastname: O'Toole
mesh_terms: D001644:Bifidobacterium / Q000235:genetics* / Q000378:metabolism*; D023281:Genomics; D006801:Humans; D007778:Lactobacillus / Q000235:genetics* / Q000378:metabolism*; D019936:Probiotics