Total lymphocyte count and hemoglobin combined to predict CD4 lymphocyte counts of less than 200 cells/mm(3) in HIV/AIDS.
OBJECTIVE
to obtain the sensitivity and specificity of combining total lymphocyte count and hemoglobin to predict the CD4 lymphocyte count below 200 cells/m3.


METHODS
this is a cross sectional study. Subject characteristics were patient with HIV/AIDS who have not been initiated ARV therapy, the age above 15 years, have a CD4 lymphocyte count data. A total of 72 patients were recruited from clinic of Edelweis or hospitalized patients at Dr. Sardjito Hospital Yogyakarta in March 2002 - March 2007. Independent t test and Mann-Whitney test was used to find out the differences of continue variable. P < or = 0.05 was considered significant.


RESULTS
a total of 72 patients were studied. Of these,50 patients (69.4%) were male, 22 patients (30.6%) were female. 53 patients with CD4 below 200 cells/mm3 and 19 patients with CD4 above 200 cells/mm3. Mean of TLCin HIV/AIDS patients with CD4 below 200 cells/mm3 were: 1013.24+/- 96.06 and CD4 above 200 cells/mm3 were 2161.36 +/- 214.66. Mean of Hb in HIV/AIDS patients with CD4 below 200 cells/mm3 were: 11.61+/- 0.30 and CD4 above 200 cells/mm3 were 12.47 +/- 0.59.Sensitivity of combined TLC+Hb man (algorithms a,b) were 80.95%, 88.09% Vs TLC 66.66%; Sensitivity of combined TLC+Hb woman (algorithms a, b) were 54.54%,54.54% Vs TLC 54.54%; Specificity of combined TLC+Hbman (algorithms a, b) were 87.50%, 87.50% Vs TLC 87.50%; Specificity of combined TLC+Hb woman (algorithms a, b)were 63.63%, 54.54% Vs TLC 90.90%.


CONCLUSIONS
adding hemoglobin to TLC (algorithms aand b in man) increased sensitivity, there by reducing the risk of false-negative results.
Wilhan
Department of Internal Medicine, Faculty of Medicine, Gadjah MadaUniversity/Dr. Sardjito Hospital, Jl. Kesehatan 1, Sekip Yogyakarta. tatwa95@yahoo.com
Budiono
Eko
E
D000328:Adult; D000465:Algorithms; D015415:Biomarkers / Q000097:blood; D018791:CD4 Lymphocyte Count; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000503:physiopathology*; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D016014:Linear Models; D018655:Lymphocyte Count; D008297:Male; D011379:Prognosis; D012680:Sensitivity and Specificity
D015415:Biomarkers; D006454:Hemoglobins