Oxidative stress and ferritin expression in the skin of patients with rosacea.
BACKGROUND
Rosacea is a common chronic light-sensitive inflammatory skin disease of unknown origin. The purpose of this work was to determine the parameters of oxidative stress, antioxidative capacity, and the pathophysiologic role of ferritin expression in skin cells of patients with rosacea.


OBJECTIVE
The investigation consisted of measurements of serum peroxide levels, serum total antioxidative potential levels, and immunohistochemical analyses of ferritin in skin tissue samples.


RESULTS
Serum peroxide levels were significantly higher and serum total antioxidative potential levels were significantly lower in patients with rosacea than in healthy control subjects (P < .05). Compared with control subjects, the number of ferritin-positive cells was significantly higher (P < .001) in skin samples from patients with rosacea, especially those with severe disease.


CONCLUSIONS
Patients with rosacea in the study were aged 30 to 70 years (average age was 56 years). Younger patients with flushing only were not included according to the request of the ethics committee, limiting the use of diagnostic biopsies only to the necessary cases.


CONCLUSIONS
The statistically significant differences in the expression of ferritin, higher peroxide levels, and lower antioxidative potential support the onset of systemic oxidative stress in patients with rosacea.
Tisma
Vesna Sredoja
VS
Polyclinic Department of Dermatology and Venereology, Dubrava University Hospital, Zagreb, Croatia.
Basta-Juzbasic
Aleksandra
A
Jaganjac
Morana
M
Brcic
Luka
L
Dobric
Ivan
I
Lipozencic
Jasna
J
Tatzber
Franz
F
Zarkovic
Neven
N
Poljak-Blazi
Marija
M
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism; D001706:Biopsy; D005260:Female; D005293:Ferritins / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D010545:Peroxides / Q000097:blood; D012393:Rosacea / Q000378:metabolism* / Q000473:pathology; D012867:Skin / Q000378:metabolism* / Q000473:pathology
D000975:Antioxidants; D010545:Peroxides; D005293:Ferritins