[Molecular epidemiological study on oxidative DNA damage among Hasake ethnic migrants in Shenzhen].
OBJECTIVE
To explore the relationship of migration and oxidative DNA damage by comparative study of oxidative DNA damage effects on people with different years of migration among Xinjiang Hasake ethnicity in Shenzhen.


METHODS
Sixty Hasake residents in Shenzhen were selected, and were divided into three groups (n=20) according to the years of migration. Major changes of their life style were investigated. 8-hydroxy-2'-deoxyguanosine (8-OH-dG) levels in urine were analyzed, and comet assay of peripheral blood lymphocytes conducted.


RESULTS
When comparing with the group having a shorter than 1 year of stay,a significant decrease of oliveira tail moment and tail/head length in comet assay in the >3 years group (P < 0.05) was observed 8-OH-dG level decreased significantly in 1-3 years group (P < 0.05) and >3 years group (P < 0.01).


CONCLUSIONS
Our results suggested that life style changes which related to migration might reduce DNA damage in Hasake nationalities.
Ke
Yue-bin
YB
Department of Genetic Toxicology, Shenzhen Center for Disease Control and Prevention, Shenzhen 518020, China.
Cheng
Jin-quan
JQ
Shuai
Zhi-hong
ZH
Zhang
Ren-li
RL
Jiang
Gao-feng
GF
Tan
Chun-rong
CR
Zhang
Zun-zhen
ZZ
D000293:Adolescent; D000328:Adult; D002681:China / Q000453:epidemiology; D020552:Comet Assay; D004249:DNA Damage; D004260:DNA Repair; D003849:Deoxyguanosine / Q000652:urine*; D006184:Habits; D006801:Humans; D008297:Male; D017720:Molecular Epidemiology; D018384:Oxidative Stress; D012907:Smoking / Q000453:epidemiology / Q000208:ethnology; D014171:Transients and Migrants; D055815:Young Adult
D003849:Deoxyguanosine