title: Self-assembled honokiol-loaded micelles based on poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) copolymer.
abstract: Self-assembled polymeric micelles are widely applied in drug delivery system (DDS). In this study, honokiol (HK) loaded micelles were prepared from biodegradable poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) (PCEC) copolymers. Micelles were prepared by self-assembly of triblock copolymer PCEC in distilled water triggered by its amphiphilic character without any organic solvent. Drug loading and encapsulation efficiency were determined by adjusting the weight ratio of HK and PCEC. The particle size and zeta potential distribution of obtained micelles were determined using Malvern laser particle sizer, and spherical geometry were observed on atomic force microscope (AFM). Otherwise, the thermo-sensitivity of honokiol-loaded micelles was monitored. And the cytotoxicity results of drug loaded micelles showed that the encapsulated honokiol remained potent antitumor effect. Moreover, in vitro release profile demonstrated a significant difference between rapid release of free honokiol and much slower and sustained release of HK-loaded micelles. These results suggested that we have successfully prepared honokiol-loaded micelles in an improved method which is safer and more efficient. The prepared micelles might be potential carriers for honokiol delivery in cancer chemotherapy.
authors.affiliation: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China.
authors.forename: XiaWei
authors.initials: X
authors.lastname: Wei
authors.forename: ChangYang
authors.initials: C
authors.lastname: Gong
authors.forename: Shuai
authors.initials: S
authors.lastname: Shi
authors.forename: ShaoZhi
authors.initials: S
authors.lastname: Fu
authors.forename: Ke
authors.initials: K
authors.lastname: Men
authors.forename: Shi
authors.initials: S
authors.lastname: Zeng
authors.forename: XiuLing
authors.initials: X
authors.lastname: Zheng
authors.forename: MaLing
authors.initials: M
authors.lastname: Gou
authors.forename: LiJuan
authors.initials: L
authors.lastname: Chen
authors.forename: LiYan
authors.initials: L
authors.lastname: Qiu
authors.forename: ZhiYong
authors.initials: Z
authors.lastname: Qian
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D001713:Biphenyl Compounds / Q000008:administration & dosage*; D045744:Cell Line, Tumor; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D007834:Lasers; D017705:Lignans / Q000008:administration & dosage*; D008175:Lung Neoplasms / Q000188:drug therapy; D008823:Micelles; D018625:Microscopy, Atomic Force; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D013696:Temperature; D000498:Allyl Compounds; D010636:Phenols
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001713:Biphenyl Compounds; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D017705:Lignans; D008823:Micelles; D011091:Polyesters; D011092:Polyethylene Glycols; C492324:poly(epsilon-caprolactone)-poly(oxyethylene)-poly(epsilon-caprolactone); C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols