Transplantation of bone marrow mononuclear cells does not affect postinfarction electrical remodeling of the heart.
We studied the effect of allotransplantation of bone marrow mononuclear cells on postinfarction remodeling of the heart in rats. The cells were transplanted into the periinfarction zone of the heart. The transplantation was performed on day 9 after coronary occlusion. It was found that on day 45 after coronary occlusion myocardial hypertrophy developed, ventricular fibrillation threshold decreased, but myocardial contractility remained within the normal. Allotransplantation of bone marrow mononuclear cells had no effect on myocardial hypertrophy and did not prevent the development of electrical instability of the heart.
Maslov
L N
LN
Institute of Cardiology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences. maslov@cardio.tsu.ru
Shakhov
V P
VP
Krylatov
A V
AV
Platonov
A A
AA
D000818:Animals; D001854:Bone Marrow Cells / Q000502:physiology*; D016026:Bone Marrow Transplantation; D006329:Heart Conduction System / Q000502:physiology; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000637:transplantation*; D008297:Male; D009203:Myocardial Infarction / Q000473:pathology / Q000503:physiopathology; D009206:Myocardium / Q000166:cytology / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D014182:Transplantation, Autologous; D020257:Ventricular Remodeling / Q000502:physiology*