Anti-atherosclerotic effect of atorvastatin and clopidogrel alone and in combination in rats.
Atherosclerosis is a disease affecting arterial blood vessels due to the accumulation of macrophage white blood cells and low density lipoproteins. Effects of atorvastatin, a recently introduced lipid lowering statin was studied alone and in combination with clopidogrel in high fat diet fed atherosclerotic rats orally. Results showed significant reduction in total serum cholesterol and malondialdehyde levels and significant improvement in urine creatinine levels. Aortic cross sections of rats treated with clopidogrel alone showed reversal of atherosclerotic calcification. The same effect was observed with the combined treatment of clopidogrel and atorvastatin. Only atorvastatin treatment did not show any histological atheroprotective effect. Atorvastatin and clopidogrel alone and in combination have offered significant atheroprotective effect. No specific advantage was seen with combined treatment of atorvastatin and clopidogrel, moreover the advantages seen with independent drug administration also reduced with combined treatment.
Srinivas
Martha
M
Pharmacology Division, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530 003, India.
Annapurna
Akula
A
Reddy
Yellu Narsimha
YN
D000818:Animals; D050197:Atherosclerosis / Q000097:blood / Q000473:pathology / Q000517:prevention & control*; D000069059:Atorvastatin; D000077144:Clopidogrel; D004036:Diet, Atherogenic; D004347:Drug Interactions; D005260:Female; D006538:Heptanoic Acids / Q000008:administration & dosage*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage; D011758:Pyrroles / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D013988:Ticlopidine / Q000008:administration & dosage / Q000031:analogs & derivatives*
D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D010975:Platelet Aggregation Inhibitors; D011758:Pyrroles; D000069059:Atorvastatin; D000077144:Clopidogrel; D013988:Ticlopidine