Colorectal carcinoma in Lagos and Sagamu, Southwest Nigeria: a histopathological review.
OBJECTIVE
To study the frequency, gender and age distribution as well as pathological characteristics of colorectal carcinoma (CRC) in Lagos and Sagamu in SW Nigeria.


METHODS
This is a retrospective pathological review of histologically diagnosed CRC from 5 laboratories in Lagos and Sagamu. The clinical data, such as age, sex and clinical summary were extracted from demographic information. Cases of anal cancer were excluded from this study.


RESULTS
There were 420 cases (237 males and 183 females) of CRC. It peaked in the 60-69 year age group (mean: 50.7; SD: 16.2), M:F ratio 1.3:1 and 23% occurred below 40 years. The majority was well to moderately differentiated adenocarcinoma 321 (76.4%), mucinous carcinoma 45 (10.7%) and signet ring carcinoma 5 (1.2%), and more common in patients under 40 years compared to well differentiated tumors. The recto-sigmoid colon was the most common site (58.6%). About 51% and 34% of cases presented at TNM stages II and III, respectively.


CONCLUSIONS
CRC is the commonest malignant gastrointestinal (GIT) tumor most commonly located in the recto-sigmoid region. The age and sex prevalence and histopathological features concur with reports from other parts of the world.
Abdulkareem
Fatimah-Biade
FB
Department of Morbid Anatomy, College of Medicine, University of Lagos, P.M.B. 12003, Surulere, Lagos, Nigeria. biade64@yahoo.co.uk
Abudu
Emmanuel-Kunle
EK
Awolola
Nicholas-Awodele
NA
Elesha
Stephen-Olafimihan
SO
Rotimi
Olorunda
O
Akinde
Olakanmi-Raphael
OR
Atoyebi
Ayoola-Oluwole
AO
Adesanya
Adedoyin-Adekunle
AA
Daramola
Adetola-Olubunmi
AO
Banjo
Adekumbiola-Aina-Fehintola
AA
Anunobi
Charles-Chidozie
CC
D000230:Adenocarcinoma / Q000453:epidemiology / Q000473:pathology; D002288:Adenocarcinoma, Mucinous / Q000453:epidemiology / Q000473:pathology; D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000453:epidemiology* / Q000473:pathology*; D018279:Carcinoma, Signet Ring Cell / Q000453:epidemiology / Q000473:pathology; D002454:Cell Differentiation; D002648:Child; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009549:Nigeria / Q000453:epidemiology; D012189:Retrospective Studies; D017678:Sex Distribution; D055815:Young Adult