Reduced structural connectivity in ventral visual cortex in congenital prosopagnosia.
Using diffusion tensor imaging and tractography, we found that a disruption in structural connectivity in ventral occipito-temporal cortex may be the neurobiological basis for the lifelong impairment in face recognition that is experienced by individuals who suffer from congenital prosopagnosia. Our findings suggest that white-matter fibers in ventral occipito-temporal cortex support the integrated function of a distributed cortical network that subserves normal face processing.
Thomas
Cibu
C
Department of Psychology, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213, USA. cibut@nmr.mgh.harvard.edu
Avidan
Galia
G
Humphreys
Kate
K
Jung
Kwan-jin
KJ
Gao
Fuqiang
F
Behrmann
Marlene
M
D000328:Adult; D000368:Aged; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D008875:Middle Aged; D009778:Occipital Lobe / Q000473:pathology / Q000503:physiopathology; D020238:Prosopagnosia / Q000151:congenital* / Q000175:diagnosis / Q000503:physiopathology*; D013702:Temporal Lobe / Q000473:pathology / Q000503:physiopathology; D014793:Visual Cortex / Q000473:pathology / Q000503:physiopathology*; D014795:Visual Pathways / Q000473:pathology / Q000503:physiopathology*