title: The spliceosome as target for anticancer treatment.
abstract: The spliceosome is a ribonucleoprotein complex involved in RNA splicing, that is, the removal of non-coding introns from precursor messenger RNA. (Alternative) Splicing events may play an essential role in tumourigenesis. The recent discovery that the spliceosome is a target for novel compounds with anticancer activity opens up new therapeutic avenues.
authors.affiliation: Department of Medical Oncology, Erasmus University Medical Centre, Rotterdam, The Netherlands.
authors.forename: R J
authors.initials: RJ
authors.lastname: van Alphen
authors.forename: E A C
authors.initials: EA
authors.lastname: Wiemer
authors.forename: H
authors.initials: H
authors.lastname: Burger
authors.forename: F A L M
authors.initials: FA
authors.lastname: Eskens
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D015195:Drug Design; D006801:Humans; D007438:Introns / Q000235:genetics; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D012261:Ribonucleoproteins / Q000235:genetics / Q000378:metabolism; D017381:Spliceosomes / Q000187:drug effects* / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D012261:Ribonucleoproteins