title: Scalarane-based metabolites isolated from the antimitotic extract of the marine sponge Hyrtios erectus.
abstract: Two novel sesterterpenes, 1 and 3, containing a scalarane-based framework, have been isolated from the sponge Hyrtios erectus collected in Papua New Guinea. Their structures and relative stereochemistry have been elucidated by analysis of their spectroscopic data.
authors.affiliation: Department of Chemistry, University of British Columbia, Vancouver, Canada.
authors.forename: Ana R
authors.initials: AR
authors.lastname: Díaz-Marrero
authors.forename: Teatulohi
authors.initials: T
authors.lastname: Matainaho
authors.forename: Rob
authors.initials: R
authors.lastname: van Soest
authors.forename: Michel
authors.initials: M
authors.lastname: Roberge
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Andersen
mesh_terms: D000818:Animals; D050256:Antimitotic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005260:Female; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010219:Papua New Guinea; D011161:Porifera / Q000737:chemistry*; D054830:Sesterterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: C476834:12-O-deacetyl-12-epi-scalarin; C533511:12-O-deacetyl-19-methoxy-12-epi-scalarin; C533510:12beta,16beta-diacetoxyscalarolbutenolide; D050256:Antimitotic Agents; D054830:Sesterterpenes