title: Hepatocellular carcinoma presenting as orbital bone metastasis.
abstract: The authors present 2 patients in the first description of hepatocellular carcinoma metastasis to the greater wing of the sphenoid. MRI of the first case showed a multilobulated lesion, of signal intensity similar to cerebrospinal fluid in all sequences, replacing the greater wing of the sphenoid and extending in the orbit, temporalis, and middle cranial fossa. CT of the second case also showed triple fossa extension of a destructive lesion in the greater wing of the sphenoid. Fine needle aspiration biopsy showed metastatic hepatocellular carcinoma in both cases.
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada.
authors.forename: John
authors.initials: J
authors.lastname: Pitts
authors.forename: Cheng-Hsien
authors.initials: CH
authors.lastname: Chang
authors.forename: Ioannis
authors.initials: I
authors.lastname: Mavrikakis
authors.forename: Aftab
authors.initials: A
authors.lastname: Shaikh
authors.forename: Jack
authors.initials: J
authors.lastname: Rootman
mesh_terms: D044963:Biopsy, Fine-Needle; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000556:secondary*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009918:Orbital Neoplasms / Q000175:diagnosis / Q000556:secondary*; D014057:Tomography, X-Ray Computed