[Some aspects of clinical kidney transplantation from marginal cadaver donors].
The results of kidney transplantation from marginal donors were compared in two groups of patients who had received high-dose dopamine (10-35 mcg/kg/min). Group 1 consisted of 652 patients with grafts from stable donors given dopamine in doses from 0 to 10 mcg/kg/min, group 2--of 112 patients with grafts from donors given high-dose dopamine (10-35 mcg/kg/min). Mean follow-up was 52 +/- 19 months. The following parameters were compared: percent of delayed graft function, primary nonfunction transplants, acute graft rejection, graft survival, biopsy-proven ischemic-reperfusion graft injury. The rate of delayed graft function, primary non function transplants was higher in group 2 (59 and 51%, 7 and 4%, respectively). Five-year survival of the transplants and recipients was less in group 2 (68 vs. 73% and 78 vs. 71%, respectively, p < 0.05). At the end of the follow-up the level of serum creatinine was 151 +/- 50 in group 1 and 165 +/- 80 mcmol/l in group 2 (p > 0.05). Thus, despite worse results in group 2, kidney transplantation from such marginal donors can be used.
Nesterenko
I V
IV
Vatazin
A V
AV
Filiptsev
P Ia
PIa
Iankovoĭ
A G
AG
D000328:Adult; D002102:Cadaver; D003404:Creatinine / Q000097:blood; D004298:Dopamine / Q000008:administration & dosage*; D015259:Dopamine Agents / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000097:blood / Q000401:mortality; D006801:Humans; D007674:Kidney Diseases / Q000401:mortality / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D020127:Recovery of Function / Q000187:drug effects; D015427:Reperfusion Injury / Q000097:blood / Q000401:mortality; D012189:Retrospective Studies; D015996:Survival Rate; D014019:Tissue Donors; D014184:Transplantation, Homologous
D015259:Dopamine Agents; D003404:Creatinine; D004298:Dopamine