Regulatory T cells and their role in rheumatic diseases: a potential target for novel therapeutic development.
Regulatory T cells have an important role in limiting immune reactions and are essential regulators of self-tolerance. Among them, CD4+CD25high regulatory T cells are the best-described subset. In this article, we summarize current knowledge on the phenotype, function, and development of CD4+CD25high regulatory T cells. We also review the literature on the role of these T cells in rheumatic diseases and discuss the potential for their use in immunotherapy.
Milojevic
Diana
D
Department of Pediatrics, UCSF, San Francisco, CA 94143, USA. milojevic@peds.ucsf.edu.
Nguyen
Khoa D
KD
Wara
Diane
D
Mellins
Elizabeth D
ED