title: Detection of breast cancer microcalcifications using a dual-modality SPECT/NIR fluorescent probe.
abstract: Efficient chemical synthesis of a trifunctional, hydroxyapatite-binding molecule, which provides simultaneous in vivo imaging by NIR fluorescence and SPECT/CT has been described. Quantitation by SPECT provides the "gold standard" by which NIR fluorescence tomography of breast cancer microcalcifications can now be compared and optimized.
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
authors.forename: Kumar R
authors.initials: KR
authors.lastname: Bhushan
authors.forename: Preeti
authors.initials: P
authors.lastname: Misra
authors.forename: Fangbing
authors.initials: F
authors.lastname: Liu
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Mathur
authors.forename: Robert E
authors.initials: RE
authors.lastname: Lenkinski
authors.forename: John V
authors.initials: JV
authors.lastname: Frangioni
mesh_terms: D000818:Animals; D002114:Calcinosis; D017610:Calcium Compounds / Q000032:analysis; D017886:Durapatite / Q000032:analysis; D005260:Female; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D008325:Mammary Neoplasms, Experimental / Q000737:chemistry / Q000000981:diagnostic imaging* / Q000378:metabolism*; D015609:Organotechnetium Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D051381:Rats; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D017610:Calcium Compounds; D005456:Fluorescent Dyes; D015609:Organotechnetium Compounds; D017886:Durapatite