[Initial immunoreaction study on PVA/n-HA + PA66 biological composite material after being implanted into animal body].
OBJECTIVE
To observe immunoreaction to PVA/n-HA+ PA66 biological composite material after being implanted into animal body.


METHODS
PVA/n-HA+PA66 composite materials were implanted into mouse subcutaneous tissue. Histologial examination was performed at 2, 4, 6 weeks, the amount of CD3, CD4+, CD8+ in blood and IL-1, IL-6, TNF-alpha in spleen cells was measured at the same time.


RESULTS
The amount of CD3, CD4+, CD8+ in mouse blood and IL-1, IL-6, TNF-alpha in mouse spleen cells were not different with the control groups at 2, 4, 6 weeks (P > 0.05). The fibrous tissue and some blood vessels were found growing into the porous materials, which resulted in composite materials intergration of proliferative structure. The reject reaction was not found.


CONCLUSIONS
PVA/n-HA+PA66 biological composite material does not cause immune rejection after being implanted into animal body, verifying its good biocompatibility.
Guo
Tao
T
Department of Orthopedic, West China Hospital, Sichuan University, Chengdu, China.
Yang
Tian-fu
TF
Wu
Jia-qi
JQ
Liu
Yang
Y
Li
Yu-bao
YB
Pei
Fu-xing
FX
D000818:Animals; D001672:Biocompatible Materials; D005260:Female; D006882:Hydroxyapatites / Q000276:immunology*; D008297:Male; D051379:Mice; D009757:Nylons; D011142:Polyvinyl Alcohol; D019736:Prostheses and Implants; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D001672:Biocompatible Materials; D006882:Hydroxyapatites; D009757:Nylons; D011142:Polyvinyl Alcohol