Gammaaminobutyric acid A receptor alpha 3 subunit is overexpressed in lung cancer.
The identification of tumor-associated antigens, which are specifically expressed in cancer tissues, is very important for immunotherapy of lung cancer. We have combined the in silico screening and experimental verifying to identify genes that are differently expressed in cancers compared with their corresponding normal tissues. Using these methods, we have identified that GABRA3 gene was overexpressed in lung cancer and rarely expressed in other cancers. Furthermore, GABRA3 protein expression was significantly higher in the lower grade of lung cancer. It may compose functional GABA-gated channel with other subunits. This study demonstrated GABRA3 could be a potential biomarker for diagnosis of lung cancer, and GABAA receptors may play an important role in cancer differentiation.
Liu
Yan
Y
Tumor Immunobiology Laboratory of Cancer Research Institute, Central South University, Changsha, Hunan Province 410078, China.
Guo
Fengjie
F
Dai
Miao
M
Wang
Di
D
Tong
Yongqing
Y
Huang
Jian
J
Hu
Jinyue
J
Li
Guancheng
G
D014408:Biomarkers, Tumor / Q000032:analysis*; D015870:Gene Expression; D020869:Gene Expression Profiling; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D012333:RNA, Messenger / Q000032:analysis; D011963:Receptors, GABA-A / Q000096:biosynthesis*; D020133:Reverse Transcriptase Polymerase Chain Reaction
D014408:Biomarkers, Tumor; C546257:GABRA3 protein, human; D012333:RNA, Messenger; D011963:Receptors, GABA-A