title: Evidence-based toxicology: "sound science" in new disguise.
abstract: The "evidence-based toxicology" proposed by Guzelian et al. departs radically from state-of-the-art toxicology by claiming that risks for humans can only be determined on the basis of human evidence. Just like the previous proposal of "sound science," "evidence-based toxicology" poses a heavy burden of proof on any effort to control exposures in order to reduce health risks to those exposed. The alleged connection between "evidence-based toxicology" and evidence-based medicine is misconceived, since the strict criteria for use of scientific data in evidence-based medicine concerns proof of therapeutic effects, while in "evidence-based toxicology" these criteria are applied to proof of harmful effects. The slogans "sound science" and "evidence-based toxicology" have both been put forward by persons with a history of extensive involvement with the tobacco industry.
authors.affiliation: Royal Institute of Technology (KTH), Stockholm, Sweden. cr@infra.kth.se
authors.forename: Christina
authors.initials: C
authors.lastname: Rudén
authors.forename: Sven Ove
authors.initials: SO
authors.lastname: Hansson
mesh_terms: D000818:Animals; D019317:Evidence-Based Medicine; D006801:Humans; D014116:Toxicology