title: Mucocutaneous manifestations in inflammatory bowel disease.
abstract: BACKGROUND
  The aim of this study was to evaluate the prevalence and features of the major cutaneous manifestations (erythema nodosum [EN] and pyoderma gangrenosum [PG]) and to determine the associations between cutaneous manifestations and other extraintestinal manifestations in patients with inflammatory bowel disease (IBD).
  
  
  METHODS
  The mucocutaneous manifestations of patients with IBD were studied between December 2002 and June 2007. All patients underwent a detailed whole body examination by a gastroenterologist and dermatologist.
  
  
  RESULTS
  In all, 352 patients were included in this study; 34 patients (9.3%) presented with at least 1 major cutaneous manifestation. The prevalence of EN (26 patients) and PG (8 patients) in IBD was 7.4% and 2.3%, respectively. EN was more common in Crohn's disease (16/118) than ulcerative colitis (10/234) (P = 0.002). EN was found to be related to disease activity of the bowel (P = 0.026). The prevalence of arthritis was significantly higher in the IBD patients with EN (11/26) than in IBD patients without EN (53/326) (P = 0.006). Arthritis was more common in IBD patients with PG (7/8) than in IBD patients without PG (57/344) (P = 0.00). IBD patients with PG were significantly more likely to have uveitis (1/8) compared with IBD patients without PG (5/344) (P = 0.017).
  
  
  CONCLUSIONS
  We found the prevalence of 2 important cutaneous manifestations to be 9.3% in IBD in Turkish patients. EN was found to be more common in Crohn's disease and is associated with an active episode of bowel disease and peripheral arthritis. In addition, PG was connected with uveitis and peripheral arthritis.
authors.affiliation: Department of Gastroenterology, Dişkapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey. yukselilhami@hotmail.com
authors.forename: Ilhami
authors.initials: I
authors.lastname: Yüksel
authors.forename: Omer
authors.initials: O
authors.lastname: Başar
authors.forename: Hilmi
authors.initials: H
authors.lastname: Ataseven
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Ertuğrul
authors.forename: Mehmet
authors.initials: M
authors.lastname: Arhan
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ibiş
authors.forename: Ulkü
authors.initials: U
authors.lastname: Dağli
authors.forename: Bilge Tunç
authors.initials: BT
authors.lastname: Demirel
authors.forename: Aysel
authors.initials: A
authors.lastname: Ulker
authors.forename: Sema
authors.initials: S
authors.lastname: Seçilmiş
authors.forename: Nurgül
authors.initials: N
authors.lastname: Saşmaz
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D001168:Arthritis / Q000453:epidemiology; D002675:Child, Preschool; D003093:Colitis, Ulcerative / Q000453:epidemiology*; D003424:Crohn Disease / Q000453:epidemiology*; D004893:Erythema Nodosum / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D017511:Pyoderma Gangrenosum / Q000453:epidemiology*; D013281:Stomatitis, Aphthous / Q000453:epidemiology*; D014421:Turkey / Q000453:epidemiology; D014605:Uveitis / Q000453:epidemiology; D055815:Young Adult