title: Gender differences in predictors of treatment attrition with high dose naltrexone in cocaine and alcohol dependence.
abstract: Recently, we reported that naltrexone at 150 mg/day significantly decreased cocaine and alcohol use for men but not women with co-occurring cocaine and alcohol dependence. The present study is an exploratory investigation of predictors that explain the different gender responses to naltrexone, with a particular focus on differential predictors of treatment attrition. No significant predictors were associated with treatment discontinuation in men. Women, however, were more likely to discontinue treatment when reporting severe pre-treatment psychiatric problems or nausea while in treatment. Further research on the impact of pre-treatment and in-treatment gender differences with naltrexone is warranted.
authors.affiliation: Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. Suh J@mail.TRC.Upenn.edu
authors.forename: Jesse J
authors.initials: JJ
authors.lastname: Suh
authors.forename: Helen M
authors.initials: HM
authors.lastname: Pettinati
authors.forename: Kyle M
authors.initials: KM
authors.lastname: Kampman
authors.forename: Charles P
authors.initials: CP
authors.lastname: O'Brien
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000150:complications / Q000188:drug therapy*; D019970:Cocaine-Related Disorders / Q000150:complications / Q000188:drug therapy*; D005260:Female; D005544:Forecasting; D006801:Humans; D008297:Male; D008875:Middle Aged; D009271:Naltrexone / Q000008:administration & dosage / Q000627:therapeutic use*; D009292:Narcotic Antagonists / Q000627:therapeutic use*; D009325:Nausea / Q000139:chemically induced; D010352:Patient Dropouts / Q000523:psychology*; D011613:Psychotherapy; D016032:Randomized Controlled Trials as Topic; D012720:Severity of Illness Index; D012727:Sex Characteristics
chemical_list: D009292:Narcotic Antagonists; D009271:Naltrexone