title: Clinically significant symptom change in children with attention-deficit/hyperactivity disorder: does it correspond with reliable improvement in functioning?
abstract: This study examined the relation between clinically significant (CS) change in symptoms of attention-deficit/hyperactivity disorder (ADHD) and of oppositional defiant disorder (ODD), and reliable change in multiple domains of functioning in children who participated in the Multimodal Treatment Study of Children with ADHD. Children with CS change in symptoms were significantly more likely than children without CS change to have reliable change across five domains of functioning. Interestingly, however, depending on the measure of functioning, 14 to 52% of children who did not achieve CS change in symptoms showed reliable improvement in functional domains. The results have implications for the definition and measurement of CS change in child treatment-outcome studies.
authors.affiliation: Ohio University, Athens, OH 45701, USA.
authors.forename: Veronika
authors.initials: V
authors.lastname: Karpenko
authors.forename: Julie Sarno
authors.initials: JS
authors.lastname: Owens
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Evangelista
authors.forename: Cassandra
authors.initials: C
authors.lastname: Dodds
mesh_terms: D001008:Anxiety Disorders / Q000150:complications; D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications / Q000175:diagnosis / Q000523:psychology* / Q000628:therapy*; D002648:Child; D002652:Child Behavior / Q000523:psychology*; D015897:Comorbidity; D005260:Female; D006801:Humans; D007398:Interpersonal Relations; D008297:Male; D019964:Mood Disorders / Q000150:complications; D010287:Parent-Child Relations; D011209:Power, Psychological; D011581:Psychological Tests; D016896:Treatment Outcome