title: Protective effect of Cox-2 allelic variants on risk of colorectal adenoma development in African Americans.
abstract: BACKGROUND
  Recent evidence indicates that single nucleotide polymorphisms (SNPs) in the Cox-2 gene may modulate the risk of colorectal adenoma development.
  
  
  METHODS
  We explored possible associations between Cox-2 polymorphisms and risk of adenoma development in an African American case-control study comprising 72 cases of advanced adenomas and 146 polyp-free controls. An exhaustive approach of genotyping 13 haplotype-tagging SNPs (ht SNPs) distributed over the entire COX-2 gene was used.
  
  
  RESULTS
  Statistically significant inverse associations were observed between the heterozygous genotypes at the 5229 G>T polymorphism in intron 5 [odds ratio (OR)=0.42; confidence interval (CI)=0.19-0.92; p=0.03] and at the 10935 A>G polymorphism in the 3' flanking region downstream from the poly A signals (OR=0.39; CI=0.18-0.83;p=0.01) and the risk for colorectal adenoma development.
  
  
  CONCLUSIONS
  The data from our pilot study suggest that allelic variants of the COX-2 gene significantly influence the risk of adenoma development in the African American population.
authors.affiliation: Department of Medicine and Cancer Center, Howard University College of Medicine, Washington, D.C., USA.
authors.forename: Hassan
authors.initials: H
authors.lastname: Ashktorab
authors.forename: Shirley
authors.initials: S
authors.lastname: Tsang
authors.forename: Brian
authors.initials: B
authors.lastname: Luke
authors.forename: Zhonghe
authors.initials: Z
authors.lastname: Sun
authors.forename: Lucile
authors.initials: L
authors.lastname: Adam-Campbell
authors.forename: John
authors.initials: J
authors.lastname: Kwagyan
authors.forename: Richard
authors.initials: R
authors.lastname: Poirier
authors.forename: Shahina
authors.initials: S
authors.lastname: Akter
authors.forename: Ahmad
authors.initials: A
authors.lastname: Akhgar
authors.forename: Duane
authors.initials: D
authors.lastname: Smoot
authors.forename: David J
authors.initials: DJ
authors.lastname: Munroe
authors.forename: Iqbal Unnisa
authors.initials: IU
authors.lastname: Ali
mesh_terms: D000236:Adenoma / Q000201:enzymology / Q000235:genetics*; D001741:Black or African American / Q000235:genetics*; D000483:Alleles; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000201:enzymology / Q000235:genetics*; D051546:Cyclooxygenase 2 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D051546:Cyclooxygenase 2