title: Pleomorphic adenoma of salivary glands does not appear to be a BRCA-1-dependent tumour in a Polish cohort.
abstract: BACKGROUND
  The aim of the study was to examine whether pleomorphic adenoma of salivary glands can occur on the basis of constitutional BRCA-1 mutations.
  
  
  METHODS
  Two hundred and sixty-eight patients affected by mixed tumour of salivary glands were examined for occurrence of three BRCA-1 mutations dominating in Poland.
  
  
  RESULTS
  BRCA-1 mutation was detected in only one of the patients, a female affected by breast cancer and pleomorphic adenoma of parotid gland. Parotid gland tumour showed clinical and histopathological features of typical pleomorphic adenoma with no morphological features of high-grade malignancy, which are characteristic of BRCA-1-dependent tumours.
  
  
  CONCLUSIONS
  Considering the low frequency of BRCA-1 mutation in the examined group and also the absence of features characterizing BRCA-1-dependent tumours in the only BRCA-1-positive case, pleomorphic adenoma of salivary glands should not be recognized as a BRCA-1 dependent tumour.
authors.affiliation: Department of Otolaryngology with Laryngological Oncology, Pomeranian Medical University, Szczecin, Poland. jakublubinski@o2.pl
authors.forename: Jakub
authors.initials: J
authors.lastname: Lubiński
authors.forename: Czesława
authors.initials: C
authors.lastname: Tarnowska
authors.forename: Ewa
authors.initials: E
authors.lastname: Jaworowska
authors.forename: Tomasz
authors.initials: T
authors.lastname: Byrski
authors.forename: Anna
authors.initials: A
authors.lastname: Jakubowska
authors.forename: Bogdan
authors.initials: B
authors.lastname: Górski
authors.forename: Stanisław
authors.initials: S
authors.lastname: Bień
authors.forename: Jacek
authors.initials: J
authors.lastname: Sygut
authors.forename: Stanisław
authors.initials: S
authors.lastname: Góźdź
authors.forename: Monika
authors.initials: M
authors.lastname: Siołek
authors.forename: Mieczysław
authors.initials: M
authors.lastname: Sulikowski
authors.forename: Jan
authors.initials: J
authors.lastname: Lubiński
mesh_terms: D008949:Adenoma, Pleomorphic / Q000235:genetics*; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D019398:Genes, BRCA1; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D012468:Salivary Gland Neoplasms / Q000235:genetics*