title: Implementation of wireless power transfer and communications for an implantable ocular drug delivery system.
abstract: A wireless power transfer and communication system based on near-field inductive coupling has been designed and implemented. The feasibility of using such a system to remotely control drug release from an implantable drug delivery system is addressed. The architecture of the wireless system is described and the signal attenuation over distance in both water and phosphate buffered saline is studied. Additionally, the health risk due to exposure to radio frequency (RF) radiation is examined using a biological model. The experimental results demonstrate that the system can trigger the release of drug within 5 s, and that such short exposure to RF radiation does not produce any significant (<or= 1 degrees C) heating in the biological model. The conclusion of the work is that this system could replace a chemical battery in an implantable system, eliminating the risks associated with battery failure and leakage and also allowing more compact designs for applications such as drug delivery.
authors.affiliation: The University of Edinburgh, Institute for Integrated Micro and Nano Systems (Part of Institute of Integrated Systems, Edinburgh Research Partnership), School of Engineering and Electronics, Edinburgh, UK. Tong-Boon.Tang@ee.ed.ac.uk
authors.forename: T B
authors.initials: TB
authors.lastname: Tang
authors.forename: S
authors.initials: S
authors.lastname: Smith
authors.forename: B W
authors.initials: BW
authors.lastname: Flynn
authors.forename: J T M
authors.initials: JT
authors.lastname: Stevenson
authors.forename: A M
authors.initials: AM
authors.lastname: Gundlach
authors.forename: H M
authors.initials: HM
authors.lastname: Reekie
authors.forename: A F
authors.initials: AF
authors.lastname: Murray
authors.forename: D
authors.initials: D
authors.lastname: Renshaw
authors.forename: B
authors.initials: B
authors.lastname: Dhillon
authors.forename: A
authors.initials: A
authors.lastname: Ohtori
authors.forename: Y
authors.initials: Y
authors.lastname: Inoue
authors.forename: J G
authors.initials: JG
authors.lastname: Terry
authors.forename: A J
authors.initials: AJ
authors.lastname: Walton
mesh_terms: D016503:Drug Delivery Systems / Q000295:instrumentation*; D004343:Drug Implants / Q000008:administration & dosage; D011211:Electric Power Supplies; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005123:Eye / Q000187:drug effects*; D006801:Humans; D009883:Ophthalmic Solutions / Q000008:administration & dosage*; D019736:Prostheses and Implants; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*; D013686:Telemetry / Q000295:instrumentation*
chemical_list: D004343:Drug Implants; D009883:Ophthalmic Solutions