Effectiveness of a 2% chlorhexidine solution mixed with calcium hydroxide against Candida albicans.
The purpose of this investigation was to examine the in vitro susceptibility of Candida albicans to a mixture of chlorhexidine and calcium hydroxide using a tube dilution test. A suspension containing C. albicans was exposed to 2% chlorhexidine solution, calcium hydroxide paste and 2% chlorhexidine mixed with calcium hydroxide in plastic tissue culture wells. The tested agents were incubated with C. albicans for 1, 24, or 72 h. All agents were effective anti-fungals at all experimental time periods tested, with the exception of exposure to calcium hydroxide for 1 h. A mixture of 2% chlorhexidine and calcium hydroxide therefore is a very effective anti-fungal agent against C. albicans.
Al-Nazhan
Saad
S
Division of Endodontics, Department of Restorative Dental Science, College of Dentistry, King Saud University, Riyadh, Saudi Arabia. snazhan@ksu.edu.sa
Al-Obaida
Mohammed
M
D000935:Antifungal Agents / Q000494:pharmacology*; D002126:Calcium Hydroxide / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D002710:Chlorhexidine / Q000494:pharmacology*; D004338:Drug Combinations; D012388:Root Canal Irrigants / Q000494:pharmacology*
D000935:Antifungal Agents; D004338:Drug Combinations; D012388:Root Canal Irrigants; D002126:Calcium Hydroxide; D002710:Chlorhexidine