Accelerated utilization of lactate under the effect of hypoxen after intensive exercise.
Administration of substrates of energy metabolism in combination with hypoxen (sulfur-containing oligoquinone) promoted the increase in blood lactate concentration during maximum exercise, accelerated lactate utilization, and reduced the lactate/pyruvate ratio during recovery. The in vivo effects are in line with hypoxen capacity to accelerate in vitro oxidation of exogenous NADH in mitochondria by the non-rotenone-dependent pathway realized with participation of cytochrome C.
Grishina
E V
EV
Laboratory of Biosystems Thermodynamics and Energy, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino. grishina_lena@rambler.ru
Khaustova
Ya V
YV
Pogorelova
V G
VG
Pogorelov
A G
AG
Kuz'mich
M K
MK
Maevskii
E I
EI
D000818:Animals; D004734:Energy Metabolism; D007773:Lactates / Q000378:metabolism*; D008297:Male; D051379:Mice; D008930:Mitochondria, Liver / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D010084:Oxidation-Reduction; D010101:Oxygen Consumption; D010647:Phenyl Ethers / Q000378:metabolism*; D010805:Physical Conditioning, Animal; D019289:Pyruvic Acid / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D007773:Lactates; D010647:Phenyl Ethers; D009243:NAD; C085806:olifen; D019289:Pyruvic Acid