Total synthesis of azumamide E and sugar amino acid-containing analogue.
An efficient and practical total synthesis of marine cyclic tetrapeptide, natural product azumamide E (1) is achieved via high-yielding reactions. The strategy also allowed us to synthesize the azumamide E-SAA (sugar amino acid) analogue (2), whose solution-phase NMR and biological activity studies were also carried out.
Chandrasekhar
Srivari
S
Organic Division-I, Indian Institute of Chemical Technology, Hyderabad, India 500 607. sriVaric@iict.res.in
Rao
Chennamaneni Lohitha
CL
Seenaiah
Mallikanti
M
Naresh
Police
P
Jagadeesh
Bharatam
B
Manjeera
Dharani
D
Sarkar
Arpita
A
Bhadra
Manika Pal
MP
D000596:Amino Acids / Q000737:chemistry*; D002241:Carbohydrates / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
D000596:Amino Acids; D002241:Carbohydrates; D010456:Peptides, Cyclic; C534894:azumamide E