[Development of novel biomaterials for bone and cartilage tissue engineering].
Three-dimensional porous scaffolds play an important role in cartilage and bone tissue engineering as temporary templates for transplanted cells to control their adhesion and proliferation to guide the formation of the new tissues. The scaffolds should be biodegradable, biocompatible, mechanically strong, and capable of being formed into desired shapes. Biodegradable synthetic polymers and naturally derived collagen have their respective advantages and drawbacks. Hybridization of the two kinds of polymers has been carried out to combine their respective advantages. This review will summarize some of the recently developed porous scaffolds having hybrid, biphasic and leakproof structures, and their application to bone and cartilage tissue engineering.
Kawazoe
Naoki
N
National Institute for Materials Science, Biomaterials Center.
Chen
Guoping
G
Tateishi
Tetsuya
T
D000818:Animals; D001672:Biocompatible Materials; D001861:Bone Regeneration; D001842:Bone and Bones; D002356:Cartilage; D019902:Chondrocytes; D003094:Collagen; D006801:Humans; D019344:Lactic Acid; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers; D016062:Porosity; D044968:Regenerative Medicine; D023822:Tissue Engineering; D054457:Tissue Scaffolds
D001672:Biocompatible Materials; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D003094:Collagen