Effect of tacrine, amiridine, akatinol memantine, and triazolam on phosphorylation, structure, and assembly of microtubules from brain microtubular proteins in Alzheimer diseases.
In in vitro experiments, amiridine in concentration of 100, 200, and 300 microM restored disturbed structure of microtubules assembled from tubulin and microtubule-associated proteins isolated from the brain of patients with Alzheimer disease. Tacrine in a concentration of 100, 250, and 500 microM inhibited phosphorylation of tubulin and microtubule-associated proteins isolated from the brain of patients with Alzheimer disease, while memantine and amiridine in the specified concentrations had no effect on phosphorylation.
Shevtsov
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PN
Laboratory of Neurochemistry, Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow. shevt@dio.ru
Shevtsova
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Burbaeva
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GSh
D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D000634:Aminoquinolines / Q000494:pharmacology*; D001921:Brain / Q000166:cytology* / Q000187:drug effects* / Q000378:metabolism; D015259:Dopamine Agents / Q000494:pharmacology; D018757:GABA Modulators / Q000494:pharmacology; D006801:Humans; D008559:Memantine / Q000494:pharmacology*; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism* / Q000648:ultrastructure; D018697:Nootropic Agents / Q000494:pharmacology; D010766:Phosphorylation; D013619:Tacrine / Q000494:pharmacology*; D014229:Triazolam / Q000494:pharmacology*
D000634:Aminoquinolines; D015259:Dopamine Agents; D018757:GABA Modulators; D008869:Microtubule-Associated Proteins; D018697:Nootropic Agents; D014229:Triazolam; D013619:Tacrine; C049860:amiridine; D008559:Memantine