title: [Correlation between the expression of thrombospondin-1 and the angiogenesis in mucoepidermoid carcinoma].
abstract: OBJECTIVE
  To study the relationship between the expression of thrombospondin-1 (TSP-1) and the angiogenesis in mucoepidermoid carcinoma.
  
  
  METHODS
  Immunohistochemistry were applied to detect the expression of TSP-1 and the value of microvessel density (MVD) in 45 mucoepidermoid carcinoma patients.
  
  
  RESULTS
  Positive expressions of TSP-1 protein were detected in 26 of the 45 (57. 78%) cases. Most positive staining for TSP-1 was observed in the cytoplasm of the cancer cells, some of those were in the extracellular matrix. The mean MVD in 45 cases with mucoepidermoid carcinoma was 60. 68 +/- 19.84 vessels per 100 field of vision. Tumors with a high expression of TSP-1 showed a low value of MVD and the correlation between TSP-1 immunocompetence and microvessel density was highly significant (r(s) = -0.942, P < 0.001).
  
  
  CONCLUSIONS
  The TSP-1 is expressed in most mucoepidermoid carcinoma and were associated with neovascularization. TSP-1 is likely to inhibit the extensive neovascularization and increased TSP-1 expression might inhibit angiogenic phenotype in mucoepidermoid carcinoma.
authors.affiliation: State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, China.
authors.forename: Sen
authors.initials: S
authors.lastname: Yang
authors.forename: Xiu-fa
authors.initials: XF
authors.lastname: Tang
authors.forename: Li-juan
authors.initials: LJ
authors.lastname: Guo
authors.forename: Ke
authors.initials: K
authors.lastname: Tan
authors.forename: Yu-tang
authors.initials: YT
authors.lastname: Cao
authors.forename: Ren-guo
authors.initials: RG
authors.lastname: Gong
authors.forename: Qing-hong
authors.initials: QH
authors.lastname: Gao
authors.forename: Ming
authors.initials: M
authors.lastname: Xuan
authors.forename: Yu-ming
authors.initials: YM
authors.lastname: Wen
authors.forename: Chang-mei
authors.initials: CM
authors.lastname: Wang
authors.forename: Xiao-yi
authors.initials: XY
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D020533:Angiogenesis Inhibitors; D018277:Carcinoma, Mucoepidermoid / Q000098:blood supply / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000098:blood supply / Q000378:metabolism*; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D019700:Thrombospondin 1 / Q000096:biosynthesis*
chemical_list: D020533:Angiogenesis Inhibitors; D019700:Thrombospondin 1