Canthin-6-one alkaloids from Picrasma quassioides and their cytotoxic activity.
A new alkaloid, 4,5-dimethoxy-10-hydroxycanthin-6-one (1), was isolated from the stem of Picrasma quassioides Bennet (Simaroubaceae) together with four known canthin-6-one alkaloids, 8-hydroxycanthin-6-one (2), 4,5-dimethoxycanthin-6-one (3), 5-hydroxy-4-methoxycanthin-6-one (4), and 3-methylcanthin-5,6-dione (5). Their structures were elucidated on the basis of spectroscopic data. The cytotoxic activity of the canthin-6-one alkaloids was evaluated using human nasopharyngeal carcinoma (CNE2) and human liver cancer (Bel-7402) cell lines. Among these isolates, compounds 1-4 exhibited significant cytotoxic activity against CNE2 cell line.
Jiang
Mei-Xiang
MX
School of Pharmaceutical Science, Central South University, Changsha, China.
Zhou
Ying-Jun
YJ
D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D002243:Carbolines; D045744:Cell Line, Tumor; D006801:Humans; D026121:Indole Alkaloids; D007211:Indoles / Q000737:chemistry*; D009287:Naphthyridines / Q000737:chemistry*; D032270:Picrasma / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D002243:Carbolines; D026121:Indole Alkaloids; D007211:Indoles; D009287:Naphthyridines; C453379:canthin-6-one