Effects of ethyl-eicosapentaenoic acid omega-3 fatty acid supplementation on hot flashes and quality of life among middle-aged women: a double-blind, placebo-controlled, randomized clinical trial.
OBJECTIVE
To compare the effects of enriched ethyl-eicosapentaenoic acid (E-EPA) omega-3 fatty acid supplementation with those of placebo on hot flashes (HFs) and quality of life among middle-aged women.


METHODS
Women were considered for participation if they were between 40 and 55 years of age and had moderate to severe psychological distress. A total of 120 women were randomly assigned to E-EPA or placebo for 8 weeks. Only women with HFs were included in this analysis (E-EPA, n = 45; placebo, n = 46). Outcomes were changes from baseline to week 8 postintervention regarding hot flash (HF) frequency (number of HFs per day), intensity and score (frequency x intensity), and Menopause-specific Quality of Life questionnaire scores.


RESULTS
At baseline, the average number of HFs was 2.8 per day. After 8 weeks, HF frequency and score decreased significantly in the E-EPA group compared with the placebo group. There was no difference in the change in HF intensity between groups. Frequency of HFs declined by a mean of 1.58 per day (95% CI, -2.18 to -0.98) in the E-EPA group and by 0.50 per day (95% CI, -1.20 to 0.20) in the placebo group. The odds of being a responder among those taking E-EPA were about three times greater than among those taking placebo (odds ratio, 2.70; 95% CI, 1.03-7.03; P = 0.04). Menopause-Specific Quality of Life scores improved significantly over time in both groups but no significant differences were noted between them.


CONCLUSIONS
Supplementation with E-EPA omega-3 fatty acid reduced HF frequency and improved the HF score relative to placebo. These results need to be confirmed by a clinical trial specifically designed to evaluate HFs in more symptomatic women.
Lucas
Michel
M
Saint-François d'Assise Hospital, Centre Hospitalier Universitaire de Québec, Québec, Canada. michel.lucas@crchul.ulaval.ca
Asselin
Geneviève
G
Mérette
Chantal
C
Poulin
Marie-Josée
MJ
Dodin
Sylvie
S
D000328:Adult; D004041:Dietary Fats / Q000008:administration & dosage; D019587:Dietary Supplements; D004311:Double-Blind Method; D015118:Eicosapentaenoic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005260:Female; D019584:Hot Flashes / Q000178:diet therapy*; D006801:Humans; D008875:Middle Aged; D011788:Quality of Life; D016896:Treatment Outcome
D004041:Dietary Fats; D015525:Fatty Acids, Omega-3; C035276:eicosapentaenoic acid ethyl ester; D015118:Eicosapentaenoic Acid