title: Decrease in adhesion molecules on polymorphonuclear leukocytes of patients with fibromyalgia.
abstract: Fibromyalgia (FM) is a chronic widespread pain condition in highly stressed humans. Because stress is known to modulate adhesion molecule expression, we determined L: -selectin (CD62L) and beta(2)-integrin (CD11b/CD18) expression on the surface of polymorphonuclear leukocytes in 22 patients with FM. As compared to age and sex-matched healthy controls, FM patients showed a significantly decreased expression of CD62L (p < 0.01) and CD11b/CD18 (p < 0.05) on polymorphonuclear leukocytes. These changes might lower the rate of polymorphonuclear leukocyte migration to sites of inflammation and thereby compromise defense against infections and pain control.
authors.affiliation: Department of Anesthesiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Marchioninistrasse 15, 81366, Munich, Germany.
authors.forename: Ines
authors.initials: I
authors.lastname: Kaufmann
authors.forename: Gustav
authors.initials: G
authors.lastname: Schelling
authors.forename: Christoph
authors.initials: C
authors.lastname: Eisner
authors.forename: Hans Peter
authors.initials: HP
authors.lastname: Richter
authors.forename: Antje
authors.initials: A
authors.lastname: Beyer
authors.forename: Till
authors.initials: T
authors.lastname: Krauseneck
authors.forename: Alexander
authors.initials: A
authors.lastname: Chouker
authors.forename: Manfred
authors.initials: M
authors.lastname: Thiel
mesh_terms: D039481:CD11b Antigen / Q000378:metabolism; D018821:CD18 Antigens / Q000378:metabolism; D016022:Case-Control Studies; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D005260:Female; D005356:Fibromyalgia / Q000378:metabolism*; D006801:Humans; D019041:L-Selectin / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism*
chemical_list: D039481:CD11b Antigen; D018821:CD18 Antigens; D015815:Cell Adhesion Molecules; D019041:L-Selectin