title: Vitiligo following a combined liver-kidney transplant.
abstract: We report an Afro-Caribbean male who developed vitiligo 10 days following a combined liver-kidney transplant from a Caucasian donor. Neither the donor nor the recipient had any previous history of vitiligo, nor of autoimmunity. The depigmentation gradually resolved by 8 weeks post-transplant with topical corticosteroids and standard maintenance immunosuppression. We propose that the skin depigmentation occurred due to the destruction of melanocytes by donor-derived alloreactive cytotoxic T-lymphocytes or antibody transferred during transplantation. Although vitiligo has been described in patients receiving allogeneic bone marrow transplantation for haematological malignancy, there are no previous reports of vitiligo post-solid organ transplantation.
authors.affiliation: Cambridge School of Clinical Medicine, University of Sheffield, UK.
authors.forename: Victoria
authors.initials: V
authors.lastname: Bradley
authors.forename: Elizabeth Helen
authors.initials: EH
authors.lastname: Kemp
authors.forename: Claire
authors.initials: C
authors.lastname: Dickinson
authors.forename: Tim
authors.initials: T
authors.lastname: Key
authors.forename: Paul
authors.initials: P
authors.lastname: Gibbs
authors.forename: Menna R
authors.initials: MR
authors.lastname: Clatworthy
mesh_terms: D015551:Autoimmunity; D006801:Humans; D007518:Isoantibodies / Q000378:metabolism; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000276:immunology; D016031:Liver Transplantation / Q000009:adverse effects* / Q000276:immunology; D008297:Male; D008544:Melanocytes / Q000276:immunology; D008875:Middle Aged; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000637:transplantation; D013997:Time Factors; D014019:Tissue Donors; D014820:Vitiligo / Q000209:etiology* / Q000276:immunology
chemical_list: D007518:Isoantibodies