[Gamma-aminobutyric acid--metabolism and its disorders].
Gamma-aminobutyric acid is a major inhibitory neurotransmitter in the central nervous system. GABA metabolism is dependent on the activity of three enzymes: glutamic acid decarboxylase, GABA-transaminase and succinic semialdehyde dehydrogenase. Decreased activity of these enzymes may cause many neurological syndromes, such as stiff-person syndrome, chronic fatigue syndrome, anxiety disorders and seizures. This article is a review of most important problems related to an impairment of GABA metabolism.
Kowalski
Antoni
A
Department of Molecular Neurochemistry, Medical University of Lodz, 6/8 Mazowiecka St., 92-215 Lodz, Poland. antek3000@tlen.pl
Rebas
Elzbieta
E
Zylińska
Ludmiła
L
D001008:Anxiety Disorders / Q000201:enzymology; D002493:Central Nervous System Diseases / Q000201:enzymology*; D015673:Fatigue Syndrome, Chronic / Q000201:enzymology; D006801:Humans; D012640:Seizures / Q000201:enzymology; D016750:Stiff-Person Syndrome / Q000201:enzymology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid