Effects of intraperitoneal injection of phenol, glycerin and acetic acid on neoplastic ascitis in guinea pigs.
OBJECTIVE
To investigate the histolytic action of a solution composed by phenol, glycerin and acetic acid on neoplastic ascitis in guinea pigs.


METHODS
Thirty-two guinea pigs were used. The animals were randomly distributed in experimental and control groups, and the effects of the peritoneal injection of the testing solution were studied. Saline solution was used for the control groups. Biochemical and anatomopathological (heart, lungs, kidneys, spleen and peritoneal serous membrane) were evaluated at 24 hours and 4 weeks of development.


RESULTS
It was observed that solution E, when infused into the peritoneal cavity, caused no clinical, histological or laboratory alterations in these animals when compared to those in the control group.


CONCLUSIONS
Given our results, it would be interesting to study the effects of the proposed solution on cases with experimental neoplastic ascites with a later view to treating it in humans.
Saad-Hossne
Rogerio
R
Department of Surgery, Botucatu School of Medicine, UNESP, Botucatu - SP, Brazil. saad@fmb.unesp.br
Hossne
William Saad
WS
Montenegro
Mario Rubens Guimarães
MR
D019342:Acetic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005990:Glycerol / Q000008:administration & dosage / Q000494:pharmacology*; D006168:Guinea Pigs; D007202:Indicators and Reagents; D007274:Injections, Intraperitoneal; D008297:Male; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D010529:Peritoneal Cavity / Q000473:pathology; D010534:Peritoneal Neoplasms / Q000188:drug therapy*; D019800:Phenol / Q000008:administration & dosage / Q000494:pharmacology*; D011897:Random Allocation
D000891:Anti-Infective Agents, Local; D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D019800:Phenol; D005990:Glycerol; D019342:Acetic Acid