An all-purpose tool for axon guidance.
The functions of the 75-kilodalton neurotrophin receptor p75(NTR) have remained enigmatic despite nearly three decades of study. Recent studies reveal that p75(NTR) is a versatile co-receptor that controls signaling by receptors for multiple ligands that provide repellant guidance cues to developing axons.
Schecterson
Leslayann C
LC
Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195-7290, USA.
Bothwell
Mark
M
D000818:Animals; D001369:Axons / Q000648:ultrastructure*; D006801:Humans; D020800:Receptor, Nerve Growth Factor / Q000502:physiology*; D015398:Signal Transduction
D020800:Receptor, Nerve Growth Factor