title: Sulphasalazine treatment in protracted familial Mediterranean fever arthritis.
abstract: Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by self-limited attacks of fever and polyserositis. Articular involvement in early-onset FMF is a common finding characterized by non-erosive, generally asymmetric monoarthritis in large joints. Protracted FMF arthritis was reported in 2.6% of Turkish patients. An 8-year-old female who has a history of FMF for 5 years applied to our hospital with complaints of persistent swelling and pain of her left knee for 8 months. The patient had been tried to be managed with non-steroidal anti-inflammatory drugs as well as intra-articulary steroids and colchicine. However, arthritis and acute phase response persisted. With sulphasalazine, complete recovery was achieved. It is our belief that sulphasalazine can be a choice of medical treatment in protracted FMF arthritis.
authors.affiliation: Department of Pediatrics, Gazi University, Ankara, Turkey.
authors.forename: Sevcan A
authors.initials: SA
authors.lastname: Bakkaloglu
authors.forename: Tekin
authors.initials: T
authors.lastname: Aksu
authors.forename: Berna
authors.initials: B
authors.lastname: Goker
authors.forename: Aysel
authors.initials: A
authors.lastname: Unlusoy
authors.forename: Harun
authors.initials: H
authors.lastname: Peru
authors.forename: Kibriya
authors.initials: K
authors.lastname: Fidan
authors.forename: Oguz
authors.initials: O
authors.lastname: Soylemezoglu
authors.forename: Enver
authors.initials: E
authors.lastname: Hasanoglu
authors.forename: Necla
authors.initials: N
authors.lastname: Buyan
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001168:Arthritis / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D002648:Child; D010505:Familial Mediterranean Fever / Q000150:complications*; D005260:Female; D006801:Humans; D007719:Knee Joint; D008279:Magnetic Resonance Imaging; D012460:Sulfasalazine / Q000627:therapeutic use*; D014421:Turkey
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D012460:Sulfasalazine