siRNA conjugate delivery systems.
Small interfering RNA (siRNA) has been chemically conjugated to a variety of bioactive molecules, lipids, polymers, peptides, and inorganic nanostructured materials to enhance their pharmacokinetic behavior, cellular uptake, target specificity, and safety. To efficiently deliver siRNAs to the target cells and tissues, many different siRNA bioconjugates were synthesized and characterized, and their gene silencing efficiencies were tested in vitro and in vivo. In this review, recent developments of siRNA bioconjugates are summarized.
Jeong
Ji Hoon
JH
College of Pharmacy, Sungkyunkwan University, Suwon 440-746, South Korea, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, South Korea.
Mok
Hyejung
H
Oh
Yu-Kyoung
YK
Park
Tae Gwan
TG
D016503:Drug Delivery Systems / Q000379:methods*; D020868:Gene Silencing; D006801:Humans; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics
D034741:RNA, Small Interfering