Total synthesis of (-)-serotobenine.
The efficient total synthesis of (-)-serotobenine (1) has been achieved by constructing an optically active dihydrobenzofuran ring via a rhodium carbenoid mediated intramolecular C-H insertion reaction, which was developed by our group. Then the possibility of racemization of 1 was investigated using optically active synthetic 1.
Koizumi
Yasuaki
Y
School of Pharmaceutical Sciences, University of Shizuoka and Global COE Program, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
Kobayashi
Hideki
H
Wakimoto
Toshiyuki
T
Furuta
Takumi
T
Fukuyama
Tohru
T
Kan
Toshiyuki
T
D001572:Benzofurans / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D007536:Isomerism; D015394:Molecular Structure
D001572:Benzofurans; D007211:Indoles; C531376:serotobenine