Association of dopamine receptor D5 gene polymorphism with peculiarities of voluntary attention in schizophrenic patients and their relatives.
We studied the relationship between DRD5 gene polymorphism presented by microsatellites with cognitive signs in 152 schizophrenic patients, 81 mentally healthy relatives, and 125 mentally healthy control individuals. An association was found between DRD5 polymorphism with efficiency of visual voluntary attention in patients (p = 0.02) and their relatives (p = 0.006). Carriers of two copies of the 148-b.p. allele were characterized by low efficiency of attention.
Golimbet
V E
VE
Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow. golimbet@mail.ru
Alfimova
M V
MV
Gritsenko
I K
IK
Lezheiko
T V
TV
Ebstein
R
R
D000328:Adult; D001288:Attention / Q000502:physiology*; D005190:Family; D005260:Female; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D009483:Neuropsychological Tests; D011110:Polymorphism, Genetic; D050641:Receptors, Dopamine D5 / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics / Q000503:physiopathology; D055815:Young Adult
D050641:Receptors, Dopamine D5