Why are MSCs therapeutic? New data: new insight.
Adult marrow-derived mesenchymal stem cells (MSCs) are able to differentiate into bone, cartilage, muscle, marrow stroma, tendon-ligament, fat and other connective tissues. The questions can be asked, what do MSCs do naturally and where is the MSC niche? New insight and clinical experience suggest that MSCs are naturally found as perivascular cells, summarily referred to as pericytes, which are released at sites of injury, where they secrete large quantities of bioactive factors that are both immunomodulatory and trophic. The trophic activity inhibits ischaemia-caused apoptosis and scarring while stimulating angiogenesis and the mitosis of tissue intrinsic progenitor cells. The immunomodulation inhibits lymphocyte surveillance of the injured tissue, thus preventing autoimmunity, and allows allogeneic MSCs to be used in a variety of clinical situations. Thus, a new, enlightened era of experimentation and clinical trials has been initiated with xenogenic and allogeneic MSCs.
Caplan
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AI
Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, OH 44106, USA. arnold.caplan@case.edu
D000328:Adult; D053687:Adult Stem Cells / Q000276:immunology / Q000473:pathology*; D015551:Autoimmunity; D006801:Humans; D007107:Immune System / Q000502:physiology; D059630:Mesenchymal Stem Cells / Q000276:immunology / Q000473:pathology*; D020286:Pericytes / Q000276:immunology / Q000473:pathology; D055153:Stem Cell Niche; D033581:Stem Cell Transplantation