[Change of plasma pro-inflammatory cytokines levels in patients with hemorrhagic fever with renal syndrome].
OBJECTIVE
To observe the changes of the plasma pro-inflammatory cytokines levels in patients with hemorrhagic fever with renal syndrome (HFRS).


METHODS
Enzyme-linked immunosorbent assay (ELISA) was performed to detect the plasma pro-inflammatory cytokines levels of 22 HFRS patients (9 mild cases and 13 moderate cases) 1, 4, and 12 weeks after they were diagnosed. Sixteen healthy blood donors were recruited as control group.


RESULTS
The levels of interleukin (IL)-1beta, IL-6, IL-10, tumor necrosis factor (TNF)-alpha, and IL-8 in HFRS patients were significantly higher than those in control group 1 week after they were diagnosed (all P < 0.01). The levels of IL-6 and TNF-alpha in HFRS patients returned to the normal levels four weeks after the diagnosis, while those of IL-1beta, IL-8, and IL-10 remained significantly higher than those in control group 12 weeks after the diagnosis (all P < 0.01). The IL-8 and IL-10 levels in mild HFRS patients were significantly higher than those in moderate HFRS patients at the same period (all P < 0.05).


CONCLUSIONS
Abnormal expressions and secretion of pro-inflammatory cytokines occurs during the disease course of HFRS.
Wang
Lu
L
Department of Infectious Diseases, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Li
Xu-Li
XL
Dai
Yi
Y
Qiu
Zhi-Feng
ZF
Li
Tai-Sheng
TS
D000328:Adult; D000818:Animals; D016207:Cytokines / Q000097:blood*; D006480:Hemorrhagic Fever with Renal Syndrome / Q000097:blood / Q000276:immunology*; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
D016207:Cytokines; D018836:Inflammation Mediators