title: Synthesis, anticonvulsant and neurotoxicity evaluation of 5-carbomethoxybenzoxazole derivatives.
abstract: A series of 5-carbomethoxybenzoxazole derivatives (6a-t) were prepared by using methyl-p-hydroxybenzoate. The identity of the compounds was confirmed on the basis of their elemental analysis and spectral data. In anti-MES test compounds 6b, 6d, 6h, 6j, 6m, 6p, 6q and 6s showed potent activity parallel to lipophilicity. Compounds 6b, 6d, 6k, 6n and 6s successfully passed the rotorod test without any sign of neurological deficit.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, Hamdard University, Hamdard Nagar, New Delhi, India. nadeems_03@yahoo.co.in
authors.forename: Nadeem
authors.initials: N
authors.lastname: Siddiqui
authors.forename: M
authors.initials: M
authors.lastname: Sarafroz
authors.forename: M Mumtaz
authors.initials: MM
authors.lastname: Alam
authors.forename: Waquar
authors.initials: W
authors.lastname: Ahsan
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001583:Benzoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001921:Brain / Q000187:drug effects; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000927:Anticonvulsants; D001583:Benzoxazoles