title: A retrospective comparison of the incidence of bacterial infection following anterior cruciate ligament reconstruction with autograft versus allograft.
abstract: OBJECTIVE
  To compare the incidence of bacterial infection in anterior cruciate ligament (ACL) reconstruction with autograft versus allograft.
  
  
  METHODS
  We completed a retrospective medical record review of ACL reconstructions performed at our institutions between 2001 and 2005. These included 170 autograft, 628 allograft, and 3 combined autograft/allograft reconstructions. Data collection included patient demographics, comorbidities, preoperative antibiotics, fixation type, and the occurrence of deep postoperative infection.
  
  
  RESULTS
  Of the 801 patients who underwent ACL reconstruction, 6 (0.75%) developed a confirmed deep infection. There were 2 confirmed deep infections in 170 autograft reconstructions (1.2%) compared with 4 confirmed deep infections in 628 allograft reconstructions (0.6%). Multivariate analysis revealed that ACL reconstruction using autograft had a nearly twice the risk of infection compared to allograft reconstructions (adjusted odds ratio, 1.83; 95% confidence interval, 0.16 to 12.94).
  
  
  CONCLUSIONS
  This study failed to find a higher rate of deep bacterial infection in ACL reconstructions when allograft tissue was used. We therefore feel that surgeons should consider allograft tissue as an alternative to autograft when there is a concern about donor-site morbidity, or for revision reconstructions.
  
  
  METHODS
  Level III, therapeutic retrospective comparative study.
authors.affiliation: Department of Orthopaedics at New England Baptist Hospital, Boston, MA 02120, USA. lkatz@nwoa.com
authors.forename: Laurie M
authors.initials: LM
authors.lastname: Katz
authors.forename: Todd C
authors.initials: TC
authors.lastname: Battaglia
authors.forename: Paul
authors.initials: P
authors.lastname: Patino
authors.forename: William
authors.initials: W
authors.lastname: Reichmann
authors.forename: David J
authors.initials: DJ
authors.lastname: Hunter
authors.forename: John C
authors.initials: JC
authors.lastname: Richmond
mesh_terms: D000293:Adolescent; D000328:Adult; D016118:Anterior Cruciate Ligament / Q000601:surgery* / Q000637:transplantation*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy / Q000453:epidemiology*; D002487:Centers for Disease Control and Prevention, U.S.; D003920:Diabetes Mellitus / Q000453:epidemiology; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies; D012907:Smoking; D013530:Surgical Wound Infection / Q000188:drug therapy / Q000453:epidemiology*; D014182:Transplantation, Autologous / Q000009:adverse effects; D014184:Transplantation, Homologous / Q000009:adverse effects; D014481:United States; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents