title: Effects of 17beta-estradiol on synaptic plasticity in the rat medial vestibular nuclei.
abstract: CONCLUSIONS
  This study shows that 17beta-estradiol (E(2)) can amplify the long-term potentiation (LTP) induced in the vestibular nuclei by high frequency stimulation (HFS), while potentiation induced by E(2) alone, which is unrelated to synaptic high frequency activation, is reversed by HFS.
  
  
  OBJECTIVE
  Like HFS, exogenous E(2) induces long-lasting enhancement of synaptic responses to vestibular afferent stimulation in the medial vestibular nuclei (MVN), through NMDA receptor activation. The aim of this study was to verify the possible interaction of E(2) and HFS in inducing LTP.
  
  
  METHODS
  In rat brainstem slices, we analysed the modifications induced in the field potential evoked in the MVN by: 1) HFS delivered after induction of E(2) effect and 2) E(2) applied after induction of HFS-LTP.
  
  
  RESULTS
  HFS reversed the E(2)-induced potentiation in most cases, while E(2) was able to increase the magnitude of potentiation induced by HFS.
authors.affiliation: Department of Internal Medicine, Section of Human Physiology, University of Perugia, Perugia, Italy. sgrassi@unipg,it
authors.forename: Silvarosa
authors.initials: S
authors.lastname: Grassi
authors.forename: Adele
authors.initials: A
authors.lastname: Frondaroli
authors.forename: Cristina
authors.initials: C
authors.lastname: Dieni
authors.forename: Mariangela
authors.initials: M
authors.lastname: Scarduzio
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D004958:Estradiol / Q000008:administration & dosage / Q000502:physiology*; D066298:In Vitro Techniques; D017774:Long-Term Potentiation; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014726:Vestibular Nuclei / Q000502:physiology*
chemical_list: D004958:Estradiol