title: Pharmacokinetics and bioequivalence evaluation of two fixed-dose tablet formulations of dihydroartemisinin and piperaquine in Vietnamese subjects.
abstract: The two fixed-dose combinations of dihydroartemisinin and piperaquine (Artekin and Arterakine) were found to be bioinequivalent in healthy Vietnamese subjects. However, because the peak plasma concentrations and areas under the concentration-time curves of dihydroartemisinin and piperaquine were only marginally different between the two formulations, similar therapeutic efficacies are expected in the treatment of malaria infections.
authors.affiliation: Department of Infectious Diseases, Military Hospital, Hanoi, Vietnam.
authors.forename: Nguyen Trong
authors.initials: NT
authors.lastname: Chinh
authors.forename: Nguyen Ngoc
authors.initials: NN
authors.lastname: Quang
authors.forename: Nguyen Xuan
authors.initials: NX
authors.lastname: Thanh
authors.forename: Bui
authors.initials: B
authors.lastname: Dai
authors.forename: Jason P
authors.initials: JP
authors.lastname: Geue
authors.forename: Russell S
authors.initials: RS
authors.lastname: Addison
authors.forename: Thomas
authors.initials: T
authors.lastname: Travers
authors.forename: Michael D
authors.initials: MD
authors.lastname: Edstein
mesh_terms: D000328:Adult; D000962:Antimalarials / Q000032:analysis / Q000493:pharmacokinetics*; D019540:Area Under Curve; D037621:Artemisinins / Q000032:analysis / Q000493:pharmacokinetics*; D002626:Chemistry, Pharmaceutical; D002853:Chromatography, Liquid; D018592:Cross-Over Studies; D004338:Drug Combinations; D006207:Half-Life; D006801:Humans; D008297:Male; D011804:Quinolines / Q000032:analysis / Q000493:pharmacokinetics*; D053719:Tandem Mass Spectrometry; D013810:Therapeutic Equivalency; D010879:Piperazines
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D004338:Drug Combinations; D011804:Quinolines; C039060:artenimol; C034759:piperaquine; D010879:Piperazines