No evidence for association between the interferon regulatory factor 1 (IRF1) gene and clinical tuberculosis.
Interferon regulatory factor 1 is a transcription factor involved in initiating a vigorous Th1 response during Mycobacterium tuberculosis infection. Therefore, we considered it as a possible candidate gene for certain polymorphisms to confer susceptibility to develop clinical tuberculosis. However, all polymorphisms with minor allele frequencies higher than 5% and haplotype frequencies in two Southeast Asian populations (Indonesian and Vietnamese) turned out not to be associated with pulmonary tuberculosis.
Vollstedt
Sabine
S
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Japan.
Yuliwulandari
Rika
R
Okamoto
Koji
K
Lien
Luu Thi
LT
Keicho
Naoto
N
Rochani
Jecti Teguh
JT
Wikaningrum
Riyani
R
Tokunaga
Katsushi
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D007214:Indonesia; D050856:Interferon Regulatory Factor-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics; D014397:Tuberculosis, Pulmonary / Q000235:genetics*; D014744:Vietnam; D055815:Young Adult
C494257:IRF1 protein, human; D050856:Interferon Regulatory Factor-1