title: Inversion of the response to serotonin in rats with traumatic shock.
abstract: Normally serotonin reduced blood pressure. It was shown that in rats with traumatic shock its hypotensive effect was transformed into hypertensive one. In vitro serotonin exhibited a slight vasoconstrictor effect on isolated rat aorta, while 24 h after injury, the strength of aortic contractions in response to serotonin increased 2.2 times. Desensitization of glucocorticoid receptors caused by injection of high doses of dexamethasone (3 mg/kg) to rats for 5 days led to similar changes in serotonin effect. We hypothesized that inversion of the response to serotonin in shock was caused by increased activity and/or expression of vasoconstrictor serotonin receptors in blood vessels.
authors.affiliation: Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences.
authors.forename: L M
authors.initials: LM
authors.lastname: Kozhevnikova
authors.forename: P P
authors.initials: PP
authors.lastname: Avdonin
authors.forename: I F
authors.initials: IF
authors.lastname: Sukhanova
authors.forename: P V
authors.initials: PV
authors.lastname: Avdonin
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects*; D007537:Isometric Contraction / Q000187:drug effects; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011965:Receptors, Glucocorticoid / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D012701:Serotonin / Q000494:pharmacology*; D012774:Shock, Traumatic / Q000503:physiopathology*
chemical_list: D011965:Receptors, Glucocorticoid; D011985:Receptors, Serotonin; D012701:Serotonin; D009638:Norepinephrine