Synthesis, anticonvulsant and neurotoxicity evaluation of 5-carbomethoxybenzoxazole derivatives.
A series of 5-carbomethoxybenzoxazole derivatives (6a-t) were prepared by using methyl-p-hydroxybenzoate. The identity of the compounds was confirmed on the basis of their elemental analysis and spectral data. In anti-MES test compounds 6b, 6d, 6h, 6j, 6m, 6p, 6q and 6s showed potent activity parallel to lipophilicity. Compounds 6b, 6d, 6k, 6n and 6s successfully passed the rotorod test without any sign of neurological deficit.
Siddiqui
Nadeem
N
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, Hamdard University, Hamdard Nagar, New Delhi, India. nadeems_03@yahoo.co.in
Sarafroz
M
M
Alam
M Mumtaz
MM
Ahsan
Waquar
W
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001583:Benzoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001921:Brain / Q000187:drug effects; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D013329:Structure-Activity Relationship
D000927:Anticonvulsants; D001583:Benzoxazoles