Cytotoxic ent-kaurane diterpenoids from Isodon henryi.
Chromatographic fractionation of the extract of Isodon henryi resulted in the isolation of seven new ENT-kaurane diterpenoids, named minheryins A-G (1-7), together with the six known ENT-kaurane diterpenoids leukamenin F (8), excisoidesin (9), leukamenin E (10), wangzaozin A (11), pseurata A (12), and racemosin A (13), which were elucidated by spectroscopic analysis. Compounds 7-13 were tested for their cytotoxicity against K562 and HepG2 cell lines, and they all exhibited significant activities with IC50 values<0.50 microg/mL. Isolates 1-5 were evaluated against the K562 cell line, and only 3 showed weak activity.
Zhao
Yong
Y
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China.
Huang
Sheng-Xiong
SX
Yang
Li-Bin
LB
Pu
Jian-Xin
JX
Xiao
Wei-Lie
WL
Li
Li-Mei
LM
Lei
Chun
C
Weng
Zhi-Ying
ZY
Han
Quan-Bin
QB
Sun
Han-Dong
HD
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005591:Chemical Fractionation; D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D020014:K562 Cells; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D045786:Diterpenes, Kaurane; D010936:Plant Extracts