title: Positive correlation between cyclooxygenase 2 and the expression of ABC transporters in non-small cell lung cancer.
abstract: BACKGROUND
  The primary method of treatment of non-small cell lung cancer (NSCLC) in stage IIIB and IV is chemotherapy. Previous data suggested a correlation between cyclooxygenase-2 (COX-2) expression and the multidrug-resistant phenotype of cancer cells.
  
  
  METHODS
  In this prospective study, 32 patients with NSCLC in stage IIIB and IV from 1,078 patients were included. The expression of COX-2 as well as the expression of the ABC transporters MDR1/P-glycoprotein (MDR1/P-gp), BCRP and MRP1 were detected immunohistochemically.
  
  
  RESULTS
  Univariate and multivariate analyses demonstrated no prognostic or predictive significance of these proteins. It was merely demonstrated that complete or partial response are favourable factors for prediction of longer progression-free survival time. However, a strong positive correlation between the expression of COX-2, MDR1/P-gp and BCRP was found in NSCLC.
  
  
  CONCLUSIONS
  These data suggest no clinical impact for the expression of MDR1/P-gp, MRP1, BCRP or COX-2 in NSCLC, but a putative coregulation of COX-2 and MDRI/P-gp and BCRP in NSCLC.
authors.affiliation: Charité-University Medicine Berlin, Campus Mitte, Institute of Pathology, D-10117 Berlin, Germany.
authors.forename: Paweł
authors.initials: P
authors.lastname: Surowiak
authors.forename: Konrad
authors.initials: K
authors.lastname: Pawełczyk
authors.forename: Adam
authors.initials: A
authors.lastname: Maciejczyk
authors.forename: Marek
authors.initials: M
authors.lastname: Pudełko
authors.forename: Jerzy
authors.initials: J
authors.lastname: Kołodziej
authors.forename: Maciej
authors.initials: M
authors.lastname: Zabel
authors.forename: Dawid
authors.initials: D
authors.lastname: Murawa
authors.forename: Marcin
authors.initials: M
authors.lastname: Drag
authors.forename: Tserenchunt
authors.initials: T
authors.lastname: Gansukh
authors.forename: Manfred
authors.initials: M
authors.lastname: Dietel
authors.forename: Hermann
authors.initials: H
authors.lastname: Lage
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000096:biosynthesis*; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D051546:Cyclooxygenase 2 / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011446:Prospective Studies; D015996:Survival Rate
chemical_list: D018528:ATP-Binding Cassette Transporters; D051546:Cyclooxygenase 2