Interlaboratory discrepancy of antigenuria results in 2 patients with AIDS and histoplasmosis.
Histoplasma polysaccharide antigen testing is used routinely to diagnose histoplasmosis. At least 3 antigen tests are commercially available. Controversy exists about the relative accuracy of these tests. We report 2 patients with AIDS and culture-confirmed Histoplasma capsulatum meningitis from whom discrepant Histoplasma polysaccharide antigen results were obtained from different laboratories and discuss the potential clinical implications of these results.
McKinsey
David S
DS
Infectious Disease Associates of Kansas City, Kansas City, MO 64132, USA. david.mckinsey@hcamidwest.com
McKinsey
Joel P
JP
Northcutt
Noelle
N
Sarria
Juan C
JC
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D000946:Antigens, Fungal / Q000652:urine*; D003951:Diagnostic Errors; D006658:Histoplasma / Q000302:isolation & purification; D006660:Histoplasmosis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007124:Immunoenzyme Techniques / Q000379:methods / Q000592:standards; D007753:Laboratories / Q000592:standards; D008297:Male; D016921:Meningitis, Fungal / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D011134:Polysaccharides / Q000652:urine; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D000935:Antifungal Agents; D000946:Antigens, Fungal; D011134:Polysaccharides; C068538:liposomal amphotericin B; D000666:Amphotericin B