title: [Characterization of rabies virus phosphoprotein in high prevalence provinces of China].
abstract: OBJECTIVE
  Characterization of rabies virus phosphoprotein through analyzation of genetic variations about rabies virus phosphoproteins in high-incidence regions in China.
  
  
  METHODS
  The nucleotide sequence of the P gene of Guangxi, Guizhou and Hunan provinces positive sample's were sequenced, and the P region's similarity and phylogenetic analyses were completed by using softer wares.
  
  
  RESULTS
  The similarity of P region's nucleotide sequence is 82.1%-100%, while, the similarity of amino acid sequence is 87.5%-100%. A little variation in phosphoprotein cannot influence its biological functions.
  
  
  CONCLUSIONS
  All rabies viruses isolated from Guangxi, Guizhou and Hunan provinces belong to genotype 1 and share same phylogenesis and same genome characteristic; Virus distribution presents unique Characterization; Some virus isolates from Hunan province and Thailand may come from the same virus.
authors.affiliation: Department of Viral Encephalitis, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China.
authors.forename: Xiao-Guang
authors.initials: XG
authors.lastname: Wang
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Tao
authors.forename: Hao
authors.initials: H
authors.lastname: Li
authors.forename: Miao
authors.initials: M
authors.lastname: Song
authors.forename: Jia-Liang
authors.initials: JL
authors.lastname: Du
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.forename: Zhao-Jun
authors.initials: ZJ
authors.lastname: Mo
authors.forename: Kai-Jiao
authors.initials: KJ
authors.lastname: Zhou
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: De-Fang
authors.initials: DF
authors.lastname: Dai
authors.forename: Ding-Ming
authors.initials: DM
authors.lastname: Wang
authors.forename: Jin-Zhu
authors.initials: JZ
authors.lastname: Zhou
authors.forename: Qing
authors.initials: Q
authors.lastname: Tang
authors.forename: Guo-Dong
authors.initials: GD
authors.lastname: Liang
mesh_terms: D000818:Animals; D002681:China / Q000453:epidemiology; D004283:Dog Diseases / Q000453:epidemiology / Q000821:virology*; D004285:Dogs; D006801:Humans; D018832:Molecular Chaperones; D008969:Molecular Sequence Data; D010750:Phosphoproteins / Q000235:genetics*; D010802:Phylogeny; D015995:Prevalence; D011818:Rabies / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology*; D011820:Rabies virus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D015678:Viral Structural Proteins / Q000235:genetics*
chemical_list: D018832:Molecular Chaperones; C103961:P phosphoprotein, Rabies virus; D010750:Phosphoproteins; D015678:Viral Structural Proteins