Anti-hepatitis B virus activity of new 1,2,4-triazol-2-yl- and 1,3,4-oxadiazol-2-yl-2-pyridinone derivatives.
A number of 1,3,4-oxadiazole, 3-9, and 1,2,4-triazole derivatives, 13-15, were synthesized starting form the acid hydrazide 1. The 1,3,4-thiadiazole derivative 12 was prepared from the substituted phenylthiosemicarbazide derivative 11 by treatment with sulfuric acid. The aryl hydrazone derivatives 10a-c were synthesized by reaction of the hydrazide 1 with the corresponding ketones. The thioalkyl derivatives 16a-e were prepared by akylation of the thiol derivatives 3 and 13 with different alkylating agents. The newly synthesized compounds were tested for their anti-HBV activity and some of these compounds showed high antiviral activity.
El-Essawy
A
A
Faculty of Science, Department of Chemistry, Menoufia University, Shebin El-Koam, Egypt.
El-Sayed
Wael A
WA
El-Kafrawy
Sherif A
SA
Morshedy
Asmaa S
AS
Abdel-Rahman
Adel H
AH
D000998:Antiviral Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004279:DNA, Viral / Q000235:genetics; D004797:Enzyme-Linked Immunosorbent Assay; D006515:Hepatitis B virus / Q000187:drug effects* / Q000235:genetics; D018197:Hepatoblastoma; D006801:Humans; D008113:Liver Neoplasms; D010069:Oxadiazoles / Q000494:pharmacology*; D016133:Polymerase Chain Reaction; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology*; D011728:Pyridones / Q000494:pharmacology*; D014230:Triazoles / Q000494:pharmacology*
D000998:Antiviral Agents; D004279:DNA, Viral; D010069:Oxadiazoles; D011725:Pyridines; D011728:Pyridones; D014230:Triazoles; C095511:trovirdine