title: Identification of two novel HLA-DRB1 alleles, HLA-DRB1*1214 and HLA-DRB1*1215, in two Taiwanese individuals.
abstract: Two novel HLA-DRB1 alleles, HLA-DRB1*1214 and HLA-DRB1*1215, were found in Taiwan using sequence-based typing method. DRB1*1214 differs from DRB1*120101 by two nucleotide substitutions on exon 2, causing amino acid changes at codon 37 (L-->F) and codon 38 (L-->V). We suggest that DRB1*1214 is the product of a gene conversion between DRB1*120101 and DRB1*140101 or DRB1*1405 and that HLA-DRB1*1215 differs from DRB1*120201 by one single nucleotide transition at exon 2, thereby causing amino acid change at codon 37 (L-->F).
authors.affiliation: Transfusion Medicine and Molecular Anthropology Research Laboratory, Mackay Memorial Hospital, Taipei, Taiwan.
authors.forename: H L
authors.initials: HL
authors.lastname: Lee
authors.forename: C C
authors.initials: CC
authors.lastname: Chu
authors.forename: J A
authors.initials: JA
authors.lastname: Trejaut
authors.forename: K L
authors.initials: KL
authors.lastname: Yang
authors.forename: M
authors.initials: M
authors.lastname: Lin
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution / Q000235:genetics; D001483:Base Sequence; D005091:Exons; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008969:Molecular Sequence Data; D012689:Sequence Homology, Nucleic Acid; D013624:Taiwan
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains