title: Pulmonary delivery of a GLP-1 receptor agonist, BMS-686117.
abstract: Alternate delivery route of therapeutic peptides is an attractive non-invasive option to patients who must chronically self-administer their medication through injections. In recent years, much attention has centered on pulmonary peptide delivery of peptide drugs such as insulin and GLP-1 mimetic peptides in the treatment of type II diabetes. In this study, we assessed the feasibility of delivering BMS-686117, an 11-mer GLP-1 receptor peptide agonist, to the lung in rats via intratracheal administration. The pharmacokinetic profiles of three spray-dried, prototype inhaled powder formulations, 80/20 BMS-686117/trehalose (I), 100% BMS-686117 (II), and 20/80 BMS-686117/mannitol (III), as well as a lyophilized BMS-686117 powder, were compared with intravenously and subcutaneously administered peptide. The spray-dried formulations were mostly spherical particles with narrow particle size distribution between 2 to 10 microm, which are better suited for inhalation delivery than the lyophilized, irregular shape powder with a wide particle size distribution between 2 to 100 microm. Prototype III exhibited the best physical characteristics and in vivo performance, with bioavailability of 45% relative to subcutaneous administration. The T(max) for lung delivered peptide formulations were almost twice as fast as subcutaneous injection, suggesting potential for rapid absorption and onset of action. This study demonstrated that pulmonary delivery is a promising, non-invasive route for the administration of BMS-686117.
authors.affiliation: Biopharmaceutics Research and Development, Bristol-Myers Squibb Company, New Brunswick, NJ 08903, USA. feng.qian1@bms.com
authors.forename: Feng
authors.initials: F
authors.lastname: Qian
authors.forename: Neil
authors.initials: N
authors.lastname: Mathias
authors.forename: Paul
authors.initials: P
authors.lastname: Moench
authors.forename: Cecilia
authors.initials: C
authors.lastname: Chi
authors.forename: Sridhar
authors.initials: S
authors.lastname: Desikan
authors.forename: Munir
authors.initials: M
authors.lastname: Hussain
authors.forename: Ronald L
authors.initials: RL
authors.lastname: Smith
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D001682:Biological Availability; D005079:Excipients / Q000737:chemistry; D005612:Freeze Drying; D000067757:Glucagon-Like Peptide-1 Receptor; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008168:Lung / Q000378:metabolism; D008297:Male; D008353:Mannitol / Q000737:chemistry; D009842:Oligopeptides / Q000008:administration & dosage / Q000493:pharmacokinetics*; D010316:Particle Size; D011208:Powders; D051381:Rats; D017207:Rats, Sprague-Dawley; D018027:Receptors, Glucagon / Q000819:agonists*; D014199:Trehalose / Q000737:chemistry
chemical_list: C539626:BMS 686117; D005079:Excipients; C000593835:Glp1r protein, rat; D000067757:Glucagon-Like Peptide-1 Receptor; D007004:Hypoglycemic Agents; D009842:Oligopeptides; D011208:Powders; D018027:Receptors, Glucagon; D008353:Mannitol; D014199:Trehalose