title: [Hemolytic uremic syndrome caused by enterohaemorrhagic Escherichia coli].
abstract: Hemolytic uremic syndrome (HUS) is characterized by microangiopathic hemolytic anemia, plaquetopenia and kidney damage. It is the leading cause of acute renal failure in pediatric age and the second for chronic renal failure. Shiga toxin-producing Escherichia coli (STEC) is the first etiologic agent of HUS being its main reservoir cattle and transmitted via contaminated food. At present, there is no specific treatment to reduce the progression of HUS. The study of the mechanisms by which STEC infects and Shiga toxin induces HUS can help to find new strategies to prevent this disease.
authors.affiliation: Laboratorio de Fisiopatogenia, Departamento de Fisiología, Facultad de Medicina, UBA. ibarra@fmed.uba.ar
authors.forename: Cristina
authors.initials: C
authors.lastname: Ibarra
authors.forename: Jorge
authors.initials: J
authors.lastname: Goldstein
authors.forename: Claudia
authors.initials: C
authors.lastname: Silberstein
authors.forename: Elsa
authors.initials: E
authors.lastname: Zotta
authors.forename: Marcela
authors.initials: M
authors.lastname: Belardo
authors.forename: Horacio A
authors.initials: HA
authors.lastname: Repetto
mesh_terms: D002648:Child; D054324:Enterohemorrhagic Escherichia coli; D004927:Escherichia coli Infections / Q000150:complications* / Q000628:therapy; D006463:Hemolytic-Uremic Syndrome / Q000382:microbiology* / Q000628:therapy; D006801:Humans; D022621:Shiga Toxin
chemical_list: D022621:Shiga Toxin