A new cytotoxic pregnanone from Calotropis gigantea.
A new pregnanone, named calotropone (1), was isolated from the EtOH extract of the roots of Calotropis gigantea L. together with a known cardiac glycoside. The structures were elucidated by a study of their physical and spectral data. Compounds 1 and 2 displayed inhibitory effects towards chronic myelogenous leukemia K562 and human gastric cancer SGC-7901 cell lines.
Wang
Zhu-Nian
ZN
Institute of Crops Genetic Resources, Chinese Academy of Tropical Agricultural Sciences, Danzhou 571737, P. R. China. wangzhunian@yahoo.com.cn
Wang
Mao-Yuan
MY
Mei
Wen-Li
WL
Han
Zhuang
Z
Dai
Hao-Fu
HF
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D031107:Calotropis / Q000737:chemistry*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D011280:Pregnanolone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared
D000972:Antineoplastic Agents, Phytogenic; C534178:calotropone; D011280:Pregnanolone