title: Synthesis and antimycobacterial activity of selected nitrobenzyloxylated benzotriazoles.
abstract: A series of 1-nitrobenzyloxybenzotriazoles was prepared by the benzylation of the respective halogenosubstituted 1-hydroxybenzotriazoles. The newly obtained compounds were tested against four Mycobacterium strains. Particularly high antimycobacterial activity, comparable with that of isoniazide, was found for 5,6-dichloro- 1-(3,5-dinitrobenzyloxy)- 1H-benzotriazole.
authors.affiliation: National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Augustynowicz-Kopeć
authors.forename: Zofia
authors.initials: Z
authors.lastname: Zwolska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Orzeszko
authors.forename: Zygmunt
authors.initials: Z
authors.lastname: Kazimierczuk
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000995:Antitubercular Agents; D014230:Triazoles