title: Colorectal carcinoma in Lagos and Sagamu, Southwest Nigeria: a histopathological review.
abstract: OBJECTIVE
  To study the frequency, gender and age distribution as well as pathological characteristics of colorectal carcinoma (CRC) in Lagos and Sagamu in SW Nigeria.
  
  
  METHODS
  This is a retrospective pathological review of histologically diagnosed CRC from 5 laboratories in Lagos and Sagamu. The clinical data, such as age, sex and clinical summary were extracted from demographic information. Cases of anal cancer were excluded from this study.
  
  
  RESULTS
  There were 420 cases (237 males and 183 females) of CRC. It peaked in the 60-69 year age group (mean: 50.7; SD: 16.2), M:F ratio 1.3:1 and 23% occurred below 40 years. The majority was well to moderately differentiated adenocarcinoma 321 (76.4%), mucinous carcinoma 45 (10.7%) and signet ring carcinoma 5 (1.2%), and more common in patients under 40 years compared to well differentiated tumors. The recto-sigmoid colon was the most common site (58.6%). About 51% and 34% of cases presented at TNM stages II and III, respectively.
  
  
  CONCLUSIONS
  CRC is the commonest malignant gastrointestinal (GIT) tumor most commonly located in the recto-sigmoid region. The age and sex prevalence and histopathological features concur with reports from other parts of the world.
authors.affiliation: Department of Morbid Anatomy, College of Medicine, University of Lagos, P.M.B. 12003, Surulere, Lagos, Nigeria. biade64@yahoo.co.uk
authors.forename: Fatimah-Biade
authors.initials: FB
authors.lastname: Abdulkareem
authors.forename: Emmanuel-Kunle
authors.initials: EK
authors.lastname: Abudu
authors.forename: Nicholas-Awodele
authors.initials: NA
authors.lastname: Awolola
authors.forename: Stephen-Olafimihan
authors.initials: SO
authors.lastname: Elesha
authors.forename: Olorunda
authors.initials: O
authors.lastname: Rotimi
authors.forename: Olakanmi-Raphael
authors.initials: OR
authors.lastname: Akinde
authors.forename: Ayoola-Oluwole
authors.initials: AO
authors.lastname: Atoyebi
authors.forename: Adedoyin-Adekunle
authors.initials: AA
authors.lastname: Adesanya
authors.forename: Adetola-Olubunmi
authors.initials: AO
authors.lastname: Daramola
authors.forename: Adekumbiola-Aina-Fehintola
authors.initials: AA
authors.lastname: Banjo
authors.forename: Charles-Chidozie
authors.initials: CC
authors.lastname: Anunobi
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000473:pathology; D002288:Adenocarcinoma, Mucinous / Q000453:epidemiology / Q000473:pathology; D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000453:epidemiology* / Q000473:pathology*; D018279:Carcinoma, Signet Ring Cell / Q000453:epidemiology / Q000473:pathology; D002454:Cell Differentiation; D002648:Child; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009549:Nigeria / Q000453:epidemiology; D012189:Retrospective Studies; D017678:Sex Distribution; D055815:Young Adult