Transplantation-mediated alloimmune thrombocytopenia: Guidelines for utilization of thrombocytopenic donors.
Transplantation-mediated alloimmune thrombocytopenia (TMAT) is donor-derived thrombocytopenia following solid-organ transplantation. To date, no clear consensus on the appropriateness of organ utilization from cadaver donors with a history of idiopathic thrombocytopenia purpura (ITP) has emerged. Herein is reported a devastating case of TMAT following liver transplantation utilizing an allograft from a donor with ITP that resulted in allograft failure. The literature is reviewed in this context to propose preliminary guidelines regarding utilization of allografts from cadaver donors with a history of ITP.
Diaz
Geraldine C
GC
Department of Anesthesiology, University of Arizona, Tucson, AZ 85724, USA.
Prowda
Joan
J
Lo
Irene J
IJ
Arepally
Gowthami M
GM
Evans
Neal
N
Wheeless
Yvonne
Y
Samstein
Benjamin
B
Guarrera
James V
JV
Renz
John F
JF
D000368:Aged; D002102:Cadaver; D006406:Hematoma / Q000000981:diagnostic imaging; D019698:Hepatitis C, Chronic / Q000150:complications; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging; D008103:Liver Cirrhosis / Q000209:etiology / Q000601:surgery* / Q000821:virology; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology* / Q000276:immunology; D017410:Practice Guidelines as Topic; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D011859:Radiography; D013921:Thrombocytopenia / Q000209:etiology* / Q000276:immunology; D014019:Tissue Donors