title: Genetic polymorphisms of transforming growth factor-beta1 and its receptors and colorectal cancer susceptibility: a population-based case-control study in China.
abstract: The TGF-beta signaling pathway plays a very important role in the control of cell proliferation and differentiation that is involved in colorectal carcinogenesis. The associations between polymorphisms of TGF-beta1 and its receptors genes and the colorectal cancer risk were assessed in a population-based case-control study (206 cases and 838 controls). We could not observe any variant in the G-800A, codon25 and codon263 of TGF-beta1 and A-364G of TGFbetaR2 in Chinese population. However, the results revealed that -509CT and TT genotypes were significantly associated with decrease risk for colorectal cancer (adjusted OR=0.58, 95% CI 0.40-0.84 and adjusted OR=0.44, 95% CI 0.29-0.68, respectively). Moreover, the linkage disequilibrium analysis revealed that TGF-beta1 C-509T and codon10 polymorphisms were in strong linkage disequilibrium, and the -509C/+29C was associated with a significantly increased risk of colorectal cancer (OR=1.32, 95% CI=1.05-1.66). Our findings indicate that the distributions of polymorphisms in TGF-beta1 and its receptors genes vary greatly among different ethnic groups, and these polymorphisms might contribute to the colorectal cancer susceptibility.
authors.affiliation: Department of Epidemiology and Health Statistics, Zhejiang University, School of Medicine, 388 Yuhang Tang Road, Hangzhou, Zhejiang 310058, China.
authors.forename: Yongjing
authors.initials: Y
authors.lastname: Zhang
authors.forename: Bing
authors.initials: B
authors.lastname: Liu
authors.forename: Mingjuan
authors.initials: M
authors.lastname: Jin
authors.forename: Qin
authors.initials: Q
authors.lastname: Ni
authors.forename: Xia
authors.initials: X
authors.lastname: Liang
authors.forename: Xinyuan
authors.initials: X
authors.lastname: Ma
authors.forename: Kaiyan
authors.initials: K
authors.lastname: Yao
authors.forename: Qilong
authors.initials: Q
authors.lastname: Li
authors.forename: Kun
authors.initials: K
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002681:China; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000208:ethnology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism; D053773:Transforming Growth Factor beta1 / Q000378:metabolism*
chemical_list: D018125:Receptors, Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1