title: Cycle changing the medium results in increased nisin productivity per cell in Lactococcus lactis.
abstract: High specific cellular nisin production was aimed by cycle changing the medium of Lactococcus lactis N8 and LAC48. The highest level of nisin production was reached with the 120 min cycles but maximal production was unstable. In shorter cycles (30 and 60 min) cells could be maintained in a high production state up to the end of the fermentation (28 and 14 cycles). N8 produced 19-fold and LAC48 15-fold more nisin with cycle changing the medium than without cycle incubation.
authors.affiliation: Department of Applied Chemistry and Microbiology, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland. omrsmk@yahoo.com
authors.forename: Omer
authors.initials: O
authors.lastname: Simsek
authors.forename: Per E J
authors.initials: PE
authors.lastname: Saris
mesh_terms: D001709:Biotechnology / Q000379:methods*; D003470:Culture Media / Q000737:chemistry*; D013294:Lactococcus lactis / Q000254:growth & development / Q000378:metabolism*; D009561:Nisin / Q000378:metabolism*; D013997:Time Factors
chemical_list: D003470:Culture Media; D009561:Nisin