title: Effect of epoetin zeta for correction of renal anemia in hemodialysis patients with thalassemia minor.
abstract: Two patients with thalassemia minor and end-stage renal failure on hemodialysis were treated with epoetin zeta (Silapo, Retacrit; STADA, Germany), a medicinal product that was developed and registered as biosimilar to epoetin alfa. Dosing was titrated individually for two patients to achieve a stable hemoglobin (Hb) concentration of 10.5-12.0 g/dL. One patient was treated intravenously with epoetin zeta; the other patient was treated subcutaneously. After 12 weeks of therapy both patients achieved Hb levels within the target range, confirming the effi cacy of epoetin zeta in patients with thalassemia minor.
authors.affiliation: Multidisciplinary Hospital for Active Treatment "St. George" Ltd., Division of Nephrology and Hemodialysis, Plovdiv, Bulgaria.
authors.forename: E
authors.initials: E
authors.lastname: Kumchev
authors.forename: R
authors.initials: R
authors.lastname: Koytchev
authors.forename: D
authors.initials: D
authors.lastname: Dimitrakov
authors.forename: P
authors.initials: P
authors.lastname: Stavrev
authors.forename: G
authors.initials: G
authors.lastname: Tsochev
authors.forename: M
authors.initials: M
authors.lastname: Siebert-Weigel
mesh_terms: D000328:Adult; D000740:Anemia / Q000188:drug therapy* / Q000209:etiology; D004921:Erythropoietin / Q000627:therapeutic use*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins; D006435:Renal Dialysis; D017086:beta-Thalassemia / Q000150:complications*
chemical_list: D011994:Recombinant Proteins; C530192:epoetin zeta; D004921:Erythropoietin