Hypothalamic control of hepatic glucose production and its potential role in insulin resistance.
The liver plays a pivotal role in the regulation of glucose metabolism because it is the key organ that maintains glucose levels during fasting. An emerging body of literature has demonstrated the important role of the hypothalamus in controlling hepatic glucose production (HGP). The hypothalamus senses circulating nutrients and hormones, conveying the energy status to the central nervous system, which, in turn, controls HGP in part by way of the autonomic nervous system. Overfeeding results in the failure of the hypothalamus to sense circulating nutrients and hormones, and in a loss of the central control of HGP.
Buettner
Christoph
C
Department of Medicine and Neuroscience, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA. christoph.buettner@mssm.edu
Camacho
Raul C
RC
D000818:Animals; D004435:Eating / Q000502:physiology; D005502:Food; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism / Q000502:physiology*; D007328:Insulin / Q000502:physiology; D007333:Insulin Resistance / Q000502:physiology*; D020738:Leptin / Q000378:metabolism / Q000502:physiology; D008099:Liver / Q000294:innervation / Q000378:metabolism* / Q000502:physiology; D008954:Models, Biological
D007328:Insulin; D020738:Leptin; D005947:Glucose