Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis.
Global proteomic analysis of post-mortem anterior temporal lobe samples from schizophrenia patients and non-schizophrenia individuals was performed using stable isotope labeling and shotgun proteomics. Our analysis resulted in the identification of 479 proteins, 37 of which showed statistically significant differential expression. Pathways affected by differential protein expression include transport, signal transduction, energy pathways, cell growth and maintenance and protein metabolism. The collection of protein alterations identified here reinforces the importance of myelin/oligodendrocyte and calcium homeostasis in schizophrenia, and reveals a number of new potential markers that may contribute to the understanding of the pathogenesis of this complex disease.
Martins-de-Souza
Daniel
D
Laboratório de Neurociências, Faculdade de Medicina da USP, Instituto de Psiquiatria, Universidade de São Paulo, Rua Dr. Ovídio Pires de Campos, No 785, s/n Consolação, São Paulo, SP, CEP 05403-010, Brazil. danms90@gmail.com
Gattaz
Wagner F
WF
Schmitt
Andrea
A
Rewerts
Christiane
C
Marangoni
Sérgio
S
Novello
José C
JC
Maccarrone
Giuseppina
G
Turck
Christoph W
CW
Dias-Neto
Emmanuel
E
D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000032:analysis; D002118:Calcium / Q000378:metabolism*; D049109:Cell Proliferation; D002851:Chromatography, High Pressure Liquid; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D008297:Male; D013058:Mass Spectrometry / Q000379:methods; D008875:Middle Aged; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein / Q000032:analysis*; D063308:Myelin-Oligodendrocyte Glycoprotein; D009419:Nerve Tissue Proteins / Q000032:analysis*; D011180:Postmortem Changes; D021381:Protein Transport; D020543:Proteome / Q000737:chemistry*; D040901:Proteomics / Q000379:methods; D012016:Reference Values; D012559:Schizophrenia / Q000378:metabolism*; D015398:Signal Transduction; D013702:Temporal Lobe / Q000737:chemistry*
D015415:Biomarkers; C571326:MOG protein, human; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein; D009419:Nerve Tissue Proteins; D020543:Proteome; D002118:Calcium