A genetic association study in the Gambia using tagging polymorphisms in the major histocompatibility complex class III region implicates a HLA-B associated transcript 2 polymorphism in severe malaria susceptibility.
The tumour necrosis factor (TNF) gene and other genes flanking it in the major histocompatibility complex (MHC) class III region are potentially important mediators of both immunity and pathogenesis of malaria. We investigated the association of severe malaria with 11 haplotype tagging-polymorphisms for 11 MHC class III candidate genes, including TNF, lymphotoxin alpha (LTA), allograft inflammatory factor 1 (AIF1), and HLA-B associated transcript 2 (BAT2). An analysis of 2,162 case-controls demonstrated the first evidence of association between a BAT2 polymorphism (rs1046089) and severe malaria.
Diakite
Mahamadou
M
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Clark
Taane G
TG
Auburn
Sarah
S
Campino
Susana
S
Fry
Andrew E
AE
Green
Angela
A
Morris
Andrew P
AP
Richardson
Anna
A
Jallow
Muminatou
M
Sisay-Joof
Fatou
F
Pinder
Margaret
M
Kwiatkowski
Dominic P
DP
Rockett
Kirk A
KA
D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008288:Malaria / Q000235:genetics*; D008297:Male; D011506:Proteins / Q000235:genetics*
D011506:Proteins; C092008:PRRC2A protein, human