title: Lymphoma of frontotemporal region with massive bone destruction and intracranial and intraorbital extension.
abstract: Primary non-Hodgkin's lymphoma with unilateral proptosis and diffuse involvement of the cra-nial vault and brain parenchyma is extremely rare. A 50-year-old woman developed a progressively increasing proptosis of her right eye, associated with a subcutaneous mass over the right frontotemporal region over the last 5 months. CT scan showed a high-density contrast-enhancing lesion with wide involvement of the cranium and intracranial and intraorbital extension. We performed a wedge biopsy for further analysis. Histological examination revealed that the tumor was non-Hodgkin's lymphoma. There was no evidence of systemic involvement. The patient received radiotherapy and was doing well at 18 months' follow-up. Primary malignant lymphoma involving the orbit and cranial vault is a rare malignancy, and treatment remains to be defined.
authors.affiliation: Department of Surgery, Datta Meghe Institute of Medical Sciences, Sawangi (Meghe), Wardha, India. dramitagrawal@gmail.com
authors.forename: Amit
authors.initials: A
authors.lastname: Agrawal
authors.forename: Arvind
authors.initials: A
authors.lastname: Sinha
mesh_terms: D001706:Biopsy; D001859:Bone Neoplasms / Q000532:radiotherapy* / Q000556:secondary; D001842:Bone and Bones / Q000473:pathology*; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000532:radiotherapy*; D008495:Medical Oncology / Q000379:methods; D008875:Middle Aged; D011878:Radiotherapy / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome