[Fertility preservation in female oncology patients].
Four women were referred to the department ofGynaecology for fertility preservation. A 33-year-old nulliparous woman with breast cancer stage pT1cN0M0 underwent an IVF-ICSI cycle; five embryos were frozen. Pre-implantation genetic diagnosis (PGD) because of BRCA2 gene mutation carriage was not carried out and more recently follow-up oocyte donation options are being considered. A second, 32-year-old nulliparous woman with breast cancer stage pT2N1M0 underwent an IVF cycle; seven embryos were frozen. The third patient was a 14-year-old girl with osteosarcoma of the distal femur, who underwent a laparoscopic unilateral ovariectomy, one day after referral, and cortical tissue was frozen. The fourth patient was a 33-year-old nulliparous woman without partner, with non-Hodgkin lymphoma stage IIA. She underwent laparoscopic ovariectomy and cortical tissue was frozen. Infertility due to cancer treatment and fertility preservation options should be discussed early in treatment planning. Patients' expectations and fertility preservation limitations are important to consider. Fertility preservation options can be conducted in specialised hospitals under institutional review board approval. It still has an experimental status.
Jenninga
E
E
Afd. Gynaecologie, Leids Universitair Medisch Centrum, Leiden. e.jenninga@lumc.nl
Kroep
J R
JR
Hilders
C G J M
CG
Louwé
L A
LA
Verburg
H J
HJ
Nortier
J W R
JW
D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000150:complications; D001943:Breast Neoplasms / Q000150:complications / Q000235:genetics; D015925:Cryopreservation / Q000379:methods*; D005193:Family Planning Services / Q000379:methods; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D007247:Infertility, Female / Q000209:etiology* / Q000628:therapy*; D054315:Oocyte Retrieval / Q000379:methods*; D012516:Osteosarcoma / Q000150:complications; D010052:Ovariectomy / Q000009:adverse effects