Deficiency of complement factor MBL in a patient required cardiac surgery after an acute myocardial infarction with underlining chronic lymphocytic leukemia.
Increasing evidence suggests that Mannan-binding lectin (MBL), the initial factor of the lectin pathway of complement, plays a role in cardiovascular diseases, i.e. inversely associated with risk of myocardial infarction (MI). In the present case, a patient with MBL deficiency underwent coronary artery bypass grafting (CABG) after an acute MI with underlining chronic lymphocytic leukemia (CLL). Post-operatively, the patient had a cerebral vascular accident and eventually expired. Analysis of his blood samples from pre-, intra-, and post-operative periods showed that MBL levels abruptly increased post-operatively. We hypothesize that the post-operative increase of MBL in the patient with pre-existing MBL deficiency may contribute to systemic inflammation, causing a detrimental effect after cardiac surgery.
Lai
Lawrence T
LT
Lee
Daniel C
DC
Ko
Wilson
W
Shevde
Ketan
K
Zhang
Ming
M
D000368:Aged; D037582:Complement Pathway, Mannose-Binding Lectin / Q000502:physiology; D001026:Coronary Artery Bypass; D017809:Fatal Outcome; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood* / Q000150:complications*; D008297:Male; D037601:Mannose-Binding Lectin / Q000097:blood* / Q000172:deficiency*; D009203:Myocardial Infarction / Q000150:complications* / Q000601:surgery*; D011183:Postoperative Complications / Q000097:blood / Q000209:etiology; D020521:Stroke / Q000097:blood / Q000209:etiology
D037601:Mannose-Binding Lectin