title: Effect of silicon content on the sintering and biological behaviour of Ca10(PO4)(6-x)(SiO4)x(OH)(2-x) ceramics.
abstract: Silicated hydroxyapatite powders (Ca10(PO4)(6-x)(SiO4)x(OH)(2-x); Si(x)HA) were synthesized using a wet precipitation method. The sintering of Si(x)HA ceramics with 0 < or = x < or = 1 was investigated. For 0 < or = x < or = 0.5, the sintering rate and grain growth decreased slightly with the amount of silicate. For larger amounts, the sintering behaviour differed with the formation of secondary phases before total densification. Sintering parameters (temperature and time) were adjusted to each composition to produce dense materials having similar microstructure without formation of these secondary phases. Dense ceramics made of pure hydroxyapatite and Si(x)HA containing various amounts of silicate (up to x = 0.6) were biologically tested in vitro with human osteoblast-like cells. The proliferation of cells on the surface of the ceramics increased up to 5 days of culture, indicating that the materials were biocompatible. However, the silicon content did not influence the cell proliferation.
authors.affiliation: Université de Limoges, CNRS, SPCTS UMR 6638, Faculté des Sciences et Techniques, 123 Avenue Albert Thomas, 87060 Limoges Cedex, France.
authors.forename: Mickaël
authors.initials: M
authors.lastname: Palard
authors.forename: Julien
authors.initials: J
authors.lastname: Combes
authors.forename: Eric
authors.initials: E
authors.lastname: Champion
authors.forename: Sylvie
authors.initials: S
authors.lastname: Foucaud
authors.forename: Aline
authors.initials: A
authors.lastname: Rattner
authors.forename: Didier
authors.initials: D
authors.lastname: Bernache-Assollant
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002516:Ceramics / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D006801:Humans; D008855:Microscopy, Electron, Scanning; D012825:Silicon / Q000737:chemistry*; D013696:Temperature; D014961:X-Ray Diffraction
chemical_list: D017886:Durapatite; D012825:Silicon