title: Cutaneous reactive angiomatosis associated with chronic lymphoid leukemia.
abstract: Cutaneous reactive angiomatosis is an unusual benign vascular disorder of the skin usually associated to systemic diseases. It is characterized by lobular or diffuse proliferation of small blood vessels with hyperplasia of endothelial cells, pericytes, and sometimes histiocytes. We report a 59-year-old man with asymptomatic erythematous-violaceous patches on back, palms, and elbows for 9 months. Laboratory examination revealed changes consistent with B-chronic lymphocytic leukemia. Cutaneous biopsy showed a predominantly lobular small blood vessel proliferation in dermis with pericytic hyperplasia and mild perivascular lymphoplasmacytic infiltrate. Spontaneous involution of lesions occurred after 6 months. A second biopsy performed at the beginning of clinical involution showed a less prominent vascular component with perivascular giant cells with coexpression of CD68 and CD 31. To our knowledge, this is the first case of cutaneous reactive angiomatosis with documented histopathological findings of clinical involution.
authors.affiliation: Department of Dermatology, Hospital de Cruces, Plaza de Cruces s/n, 48903 Baracaldo, Vizcaya, Spain. Eacebo@aedv.es
authors.forename: Elvira Acebo
authors.initials: EA
authors.lastname: Mariñas
authors.forename: Nerea
authors.initials: N
authors.lastname: Vidaurrazaga
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Burgos-Bretones
authors.forename: Xabier
authors.initials: X
authors.lastname: Eizagirre
authors.forename: Zuriñe Martínez
authors.initials: ZM
authors.lastname: de Lagrán
authors.forename: Rosa
authors.initials: R
authors.lastname: Izu
authors.forename: José Luis
authors.initials: JL
authors.lastname: Díaz-Pérez
mesh_terms: D000798:Angiomatosis / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D001706:Biopsy; D002908:Chronic Disease; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism; D012867:Skin / Q000098:blood supply / Q000378:metabolism / Q000473:pathology; D012871:Skin Diseases / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D019408:Platelet Endothelial Cell Adhesion Molecule-1; C067980:CD68 antigen, human; D000097382:CD68 Molecule