Apolipoprotein A5 gene -1131T/C polymorphism is associated with the risk of metabolic syndrome in ethnic Chinese in Taiwan.
BACKGROUND
The -1131T>C polymorphism in the apolipoprotein gene A5 (APOA5) was found to be associated with increased levels of plasma triglyceride and decreased levels of high-density lipoprotein cholesterol (HDL-C), which are characteristic dyslipidemic components of metabolic syndrome. This study aimed to identify a link between this polymorphism and the risk of metabolic syndrome.


METHODS
The sample population comprised 615 unrelated subjects, 18.7% of whom had metabolic syndrome. Genotypes were determined via polymerase chain reaction, restriction mapping with MseI, and gel electrophoresis.


RESULTS
A significantly higher level of triglycerides and a lower level of HDL-C were noted in carriers of the -1131C allele than in the non-carriers (p<0.001 and p=0.044, respectively). The frequency of the -1131C allele in the metabolic syndrome-affected subjects was significantly higher than that of the group of unaffected subjects (37.4% vs. 27.7%, p=0.004). Even after adjusting for age, gender, smoking, regular exercise, and waist-to-hip ratio, the APOA5 -1131C allele carriers remained significantly associated with an increased risk of metabolic syndrome (OR=1.77, 95% CI, 1.13-2.77; p=0.012).


CONCLUSIONS
These results indicate that the association of APOA5 -1131T>C polymorphism with dyslipidemia can also contribute to an increased susceptibility to metabolic syndrome in the Chinese, as a result of its effect on triglyceride metabolism.
Hsu
Lung-An
LA
Department of Internal Medicine, The First Cardiovascular Division, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taipei, Taiwan. hsula@adm.cgmh.org.tw
Ko
Yu-Lin
YL
Chang
Chi-Jen
CJ
Teng
Ming-Sheng
MS
Wu
Semon
S
Hu
Chiao-Feng
CF
D000328:Adult; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011795:Surveys and Questionnaires; D013624:Taiwan / Q000208:ethnology
C437704:APOA5 protein, human; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A