DNA2 resolves expanding flap in mitochondrial base excision repair.
In a recent issue of Molecular Cell, Zheng et al. (2008) demonstrated that human DNA2, originally identified in yeast as a nuclear DNA replication and repair factor, functions exclusively in mammalian mitochondria in the recently discovered long-patch base excision repair pathway.
Copeland
William C
WC
Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. copelan1@niehs.nih.gov
Longley
Matthew J
MJ
D002467:Cell Nucleus / Q000201:enzymology; D004265:DNA Helicases / Q000378:metabolism*; D004260:DNA Repair; D004261:DNA Replication; D004272:DNA, Mitochondrial / Q000378:metabolism; D003851:Deoxyribonucleases / Q000378:metabolism*; D045585:Flap Endonucleases / Q000378:metabolism*; D006801:Humans; D008928:Mitochondria / Q000201:enzymology; D008954:Models, Biological
D004272:DNA, Mitochondrial; D003851:Deoxyribonucleases; D045585:Flap Endonucleases; D004265:DNA Helicases; C509908:DNA2 protein, human