title: Tuning the chiral environment of C2-symmetric diene ligands: development of 3,7-disubstituted bicyclo[3.3.1]nona-2,6-dienes.
abstract: Through the structural analysis of bicyclo[3.3.1]nona-2,6-dienes, new C(2)-symmetric chiral diene ligands 1 based on 3,7-disubstituted bicyclo[3.3.1]nona-2,6-diene framework have been designed and synthesized. These chiral ligands readily bind to rhodium(I) and provide a different chiral environment from the existing chiral dienes. The rhodium complexes thus obtained act as effective catalysts for 1,4-addition of alkenyl- and arylboronic acids to various alpha,beta-unsaturated ketones, including several combinations that were previously difficult to provide high enantioselectivity.
authors.affiliation: Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan. shintani@kuchem.kyoto-u.ac.jp
authors.forename: Ryo
authors.initials: R
authors.lastname: Shintani
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Ichikawa
authors.forename: Keishi
authors.initials: K
authors.lastname: Takatsu
authors.forename: Fu-Xue
authors.initials: FX
authors.lastname: Chen
authors.forename: Tamio
authors.initials: T
authors.lastname: Hayashi