When the gut talks to bone.
Mutations in LRP5, a coreceptor for Wnt proteins, cause the disease osteoporosis pseudoglioma. A new study by Yadav et al. (2008) now challenges the view that LRP5 controls bone mass through Wnt signaling in bone and argues instead that LRP5 regulates bone mass indirectly through its effects on serotonin synthesis in the gut.
Long
Fanxin
F
Department of Medicine and Department of Developmental Biology, Washington University Medical School, St. Louis, MO 63131, USA. flong@wustl.edu
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D041981:Gastrointestinal Tract / Q000378:metabolism*; D006801:Humans; D026502:LDL-Receptor Related Proteins / Q000378:metabolism*; D060492:Low Density Lipoprotein Receptor-Related Protein-5; D010024:Osteoporosis / Q000235:genetics / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism; D051153:Wnt Proteins / Q000378:metabolism
D026502:LDL-Receptor Related Proteins; C555482:LRP5 protein, human; D060492:Low Density Lipoprotein Receptor-Related Protein-5; D051153:Wnt Proteins; D012701:Serotonin