Development of clindamycin-loaded wound dressing with polyvinyl alcohol and sodium alginate.
To develop a clindamycin-loaded wound dressing, cross-linked hydrogel films were prepared using freeze-thawing method with various mixtures of polyvinyl alcohol (PVA) and sodium alginate (SA). The physicochemical properties such as swelling ratio, tensile strength and elongation of hydrogels were evaluated. The drug release from this clindamycin-loaded hydrogel, in vitro protein adsorption test and in vivo wound healing observations in rats were then performed. Increased SA concentration decreased the gelation %, maximum strength and break elongation, but it resulted into an increment in the swelling ability, elasticity and thermal stability of hydrogel film. However, SA had insignificant effect on the release of clindamycin. This hydrogel improved the healing rate of artificial wounds in rats. Thus, a clindamycin-loaded wound dressing with PVA and SA hydrogel should be a candidate for wound care.
Kim
Jong Oh
JO
Dong-A Pharm. Co., Ltd., Yongin-Si, Kyunggi-Do 449-905, South Korea.
Choi
Jun Young
JY
Park
Jung Kil
JK
Kim
Jeong Hoon
JH
Jin
Sung Giu
SG
Chang
Sun Woo
SW
Li
Dong Xun
DX
Hwang
Ma-Ro
MR
Woo
Jong Soo
JS
Kim
Jung-Ae
JA
Lyoo
Won Seok
WS
Yong
Chul Soon
CS
Choi
Han-Gon
HG
D000042:Absorption; D000464:Alginates / Q000737:chemistry*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001458:Bandages; D002981:Clindamycin / Q000008:administration & dosage*; D003432:Cross-Linking Reagents; D004355:Drug Stability; D005079:Excipients; D005615:Freezing; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D020100:Hydrogels; D008297:Male; D008422:Materials Testing; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000473:pathology; D013499:Surface Properties; D013718:Tensile Strength; D014947:Wounds and Injuries / Q000473:pathology / Q000628:therapy
D000464:Alginates; D000900:Anti-Bacterial Agents; D003432:Cross-Linking Reagents; D005079:Excipients; D006603:Hexuronic Acids; D020100:Hydrogels; D011506:Proteins; D002981:Clindamycin; D020723:Glucuronic Acid; D011142:Polyvinyl Alcohol