Cl- conduction of GABA(A)-receptor complex of synaptic membranes of rat brain cortex after development of chronic epileptization of the brain (pharmacological kindling).
Experiments on Wistar rats showed that basal and muscimol-induced 36Cl- entry into synaptoneurosomes isolated from the brain cortex decreased after kindling (30 mg/kg pentylenetetrazole intraperitoneally for 30 days) in animals with seizure severity score 4-5. Changes in Cl- conduction during kindling are discussed.
Rebrov
I G
IG
Laboratory of Epileptogenesis, Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
Karpova
M N
MN
Andreev
A A
AA
Klishina
N Y
NY
Kalinina
M V
MV
Kusnetzova
L V
LV
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D002712:Chlorides / Q000378:metabolism*; D002713:Chlorine; D007696:Kindling, Neurologic / Q000502:physiology*; D008297:Male; D009118:Muscimol / Q000494:pharmacology; D010433:Pentylenetetrazole / Q000494:pharmacology; D011868:Radioisotopes; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000378:metabolism*; D013570:Synaptic Membranes / Q000187:drug effects / Q000502:physiology*
D002712:Chlorides; D011868:Radioisotopes; D011963:Receptors, GABA-A; D009118:Muscimol; D002713:Chlorine; D010433:Pentylenetetrazole