title: Gene expression profile in the peripheral blood of patients with prostate cancer and benign prostatic hyperplasia.
abstract: BACKGROUND
  Prostate cancer consists of multifactorial and multifocal events, generating differential gene expression in tumor cells.
  
  
  METHODS
  The molecular profile of 14 gene expression was analyzed through cDNA array in blood samples of patients with prostate cancer (PCa) and benign prostatic hyperplasia (BPH).
  
  
  RESULTS
  Messenger RNA from patient's blood showed significant differences between PCa and BPH groups only for the NOS3 gene, with an occurrence chance for PCa5.8-fold higher than BPH disease.
  
  
  CONCLUSIONS
  The NOS3 gene expression in the patient's blood may be used as a putative biomarker for prostate cancer.
authors.forename: Vivian
authors.initials: V
authors.lastname: Alonso
authors.forename: Adriana F
authors.initials: AF
authors.lastname: Neves
authors.forename: Karina
authors.initials: K
authors.lastname: Marangoni
authors.forename: Paula C B
authors.initials: PC
authors.lastname: Faria
authors.forename: Ana Paula P
authors.initials: AP
authors.lastname: Freschi
authors.forename: Andréia C
authors.initials: AC
authors.lastname: Capaneli
authors.forename: Juliana
authors.initials: J
authors.lastname: Meola
authors.forename: Luiz R
authors.initials: LR
authors.lastname: Goulart
mesh_terms: D000328:Adult; D015870:Gene Expression; D020869:Gene Expression Profiling; D052138:Genes, Neoplasm / Q000235:genetics; D006801:Humans; D008297:Male; D052250:Nitric Oxide Synthase Type III / Q000097:blood / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis; D011470:Prostatic Hyperplasia / Q000097:blood* / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000235:genetics*; D012333:RNA, Messenger / Q000097:blood / Q000235:genetics
chemical_list: D012333:RNA, Messenger; C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III