Plasma exchange for removal of antibeta1-adrenergic receptor antibody in a small child with dilated cardiomyopathy.
A 5-year-old boy was diagnosed with dilated cardiomyopathy (DCM) at 8 months of age. He underwent plasma exchange (PE) three times during 4 days because his antibeta1-adrenergic receptor antibody titer was 160 times the background density on enzyme-linked immunosorbent assay. BNP titer decreased from 1320 pg/ml before to 506 pg/ml after PE. Dobutamine infusion was discontinued after PE because of improving cardiac function. After PE, his antibeta1-adrenergic receptor antibody titer was < 20 times the background density. When patients have a high titer of antibeta1-adrenergic receptor antibody, PE should be considered, even in small children, as an alternative treatment.
Sugiyama
Hisashi
H
Department of Pediatrics, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan. sugiyama@hsp.ncvc.go.jp
Hoshiai
Minako
M
Sugita
Kanji
K
Matsuda
Ken-ichi
K
D001323:Autoantibodies / Q000276:immunology*; D002311:Cardiomyopathy, Dilated / Q000276:immunology / Q000628:therapy*; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010951:Plasma Exchange / Q000379:methods*; D018342:Receptors, Adrenergic, beta-1 / Q000276:immunology*
D001323:Autoantibodies; D018342:Receptors, Adrenergic, beta-1