Chiral carboxylic acids and their effects on melting-point behaviour in co-crystals with isonicotinamide.
The crystal structures of co-crystals of two systems of chiral carboxylic acids, optically active and racemic 2-phenylpropionic acid and 2-phenylbutyric acid, with isonicotinamide are reported to investigate the effects of the chirality of the chiral carboxylic acids on the melting point of the co-crystal complexes. It was found that the racemic co-crystal has a higher melting point than the optically active co-crystal, which correlates with the denser packing arrangement inherent in centrosymmetric space groups.
Lemmerer
Andreas
A
Centre for Supramolecular Chemistry Research, Department of Chemistry, University of Cape Town, Cape Town, South Africa. andreas.lemmerer@gmail.com
Báthori
Nikoletta B
NB
Bourne
Susan A
SA
D002152:Calorimetry, Differential Scanning; D003460:Crystallization; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D008968:Molecular Conformation; D009536:Niacinamide / Q000138:chemical synthesis / Q000737:chemistry*; D010654:Phenylbutyrates / Q000138:chemical synthesis / Q000737:chemistry*; D010666:Phenylpropionates / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism; D044366:Transition Temperature
D010654:Phenylbutyrates; D010666:Phenylpropionates; D009536:Niacinamide; C027681:isonicotinamide; C013025:hydratropic acid; C039714:2-phenylbutyric acid