title: Highly enantioselective 1,3-dipolar cycloaddition of azomethine ylides catalyzed by copper(I)/TF-BiphamPhos complexes.
abstract: A new and highly efficient Cu(I)/TF-BiphamPhos catalytic system exhibited excellent reactivity, enantio-/diastereoselectivity, and structural scope in asymmetric 1,3-dipolar cycloaddition of azomethine ylides with 0.1-3 mol % of catalyst loading. The present methodology is the best result for asymmetric cycloaddition of azomethine ylides, especially derived from amino esters other than glycinate in terms of reactivity and enantioselectivity.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, PR China 430072. cjwang@whu.edu.cn
authors.forename: Chun-Jiang
authors.initials: CJ
authors.lastname: Wang
authors.forename: Gang
authors.initials: G
authors.lastname: Liang
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Xue
authors.forename: Feng
authors.initials: F
authors.lastname: Gao
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D001391:Azo Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D002621:Chemistry / Q000379:methods*; D003300:Copper / Q000737:chemistry*; D046911:Macromolecular Substances / Q000737:chemistry; D008956:Models, Chemical; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry; D013237:Stereoisomerism; D013696:Temperature; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000596:Amino Acids; D001391:Azo Compounds; D046911:Macromolecular Substances; D013882:Thiosemicarbazones; C512188:azomethine; D003300:Copper; D009584:Nitrogen