title: Neuroprotective effect of afobazole on rats with bilateral local photothrombosis of vessels in the prefrontal cortex.
abstract: We studied the neuroprotective effect of a new selective anxiolytic afobazole on rats with bilateral focal ischemic stroke in the prefrontal cortex caused by photothrombosis. Intraperitoneal injection of 5 mg/kg afobazole 1 h after surgery and over the next 8 days (daily treatment) produced a neuroprotective effect. Afobazole was far superior to the reference cerebroprotective drug cavinton (4 mg/kg) by neuroprotective activity.
authors.affiliation: V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow.
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
authors.forename: G A
authors.initials: GA
authors.lastname: Romanova
authors.forename: F M
authors.initials: FM
authors.lastname: Shakova
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001562:Benzimidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D001808:Blood Vessels / Q000473:pathology*; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology; D007274:Injections, Intraperitoneal; D008027:Light; D008297:Male; D051379:Mice; D009025:Morpholines / Q000008:administration & dosage / Q000627:therapeutic use*; D009043:Motor Activity / Q000502:physiology; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D017397:Prefrontal Cortex / Q000473:pathology*; D051381:Rats; D020521:Stroke / Q000188:drug therapy* / Q000473:pathology
chemical_list: C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D014151:Anti-Anxiety Agents; D001562:Benzimidazoles; D009025:Morpholines; D018696:Neuroprotective Agents