Notoamides F-K, prenylated indole alkaloids isolated from a marine-derived Aspergillus sp.
Six new prenylated indole alkaloids, named notoamides F-K (8-13), were isolated from a marine-derived Aspergillus sp. Their structures, including absolute configurations, were elucidated by spectroscopic methods. Notoamide I (11) showed weak cytotoxicity against HeLa cells with an IC(50) value of 21 microg/mL.
Tsukamoto
Sachiko
S
Graduate School of Science, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan. sachiko@faculty.chiba-u.jp
Kato
Hikaru
H
Samizo
Masayuki
M
Nojiri
Yuka
Y
Onuki
Hiroyuki
H
Hirota
Hiroshi
H
Ohta
Tomihisa
T
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry*; D049872:Bivalvia / Q000382:microbiology; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry; D008386:Marine Biology; D015394:Molecular Structure; D009792:Oceans and Seas
D000970:Antineoplastic Agents; D026121:Indole Alkaloids; C534639:notoamide I