title: Metal-mediated cyclization of aryl and benzyl glycidyl ethers: a complete scenario.
abstract: Enantiomerically pure aryl and benzyl glycidyl ethers undergo stereospecific cyclizations leading to 3-chromanols or to tetrahydrobenzo[c]oxepin-4-ols under mild conditions in the presence of a catalytic amount of FeBr3/3AgOTf. The same processes are also mediated, albeit in a much less efficient manner, by AuCl3/3AgOTf. The set of active mediators in this group of processes (BF3 x Et2O, FeBr3, FeBr3/3AgOTf, AuCl3/3AgOTf) shows its nature as Friedel-Crafts reactions and disfavors the intermediacy of arylgold species.
authors.affiliation: Institute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans 16, 43007 Tarragona, Spain.
authors.forename: Rocío
authors.initials: R
authors.lastname: Marcos
authors.forename: Carles
authors.initials: C
authors.lastname: Rodríguez-Escrich
authors.forename: Clara I
authors.initials: CI
authors.lastname: Herrerías
authors.forename: Miquel A
authors.initials: MA
authors.lastname: Pericàs