Effects of Salvia miltiorrhiza on intercellular adhesion molecule 1 protein expression in the lungs of rats with severe acute pancreatitis or obstructive jaundice.
OBJECTIVE
The objective of the study was to observe the effects of Salvia miltiorrhiza on intercellular adhesion molecule 1 (ICAM-1) protein expression in the lungs of rats with severe acute pancreatitis (SAP) or obstructive jaundice (OJ).


METHODS
A total of 288 rats were used for SAP- and OJ-associated experiments. The rats were randomly divided into sham-operated, model control, and treated group. According to the difference of time points after operation, the SAP rats of each group were subdivided into 3-, 6-, and 12-hour groups, whereas the OJ rats were divided into 7-, 14-, 21-, and 28-day groups. The contents of interleukin (IL) 6, IL-18, nitric oxide, malondialdehyde, and superoxide dismutase in serum were determined, and pathological changes and ICAM-1 protein expression in the lungs were observed.


RESULTS
Compared with the respective model control groups, in treated groups of SAP and OJ rats, the numbers of dead rats declined; serum superoxide dismutase content significantly increased, and serum IL-18, IL-6, and malondialdehyde contents were significantly decreased; the positive staining intensity of ICAM-1 protein in the lungs decreased significantly (P < 0.05, P < 0.01, or P < 0.001); and pathological changes in the lungs were relieved.


CONCLUSIONS
Salvia miltiorrhiza plays a positive role in the protection of the lungs of SAP and OJ rats.
Xiping
Zhang
Z
Department of General Surgery, Hangzhou First People's Hospital, Hangzhou, Zhejiang Province, China. zxp99688@vip.163.com
Yang
Cai
C
Dijiong
Wu
W
Jie
Zhang
Z
Qian
Ye
Y
Xinge
Jiang
J
Meili
Ma
M
Qijun
Yang
Y
Qi
Xie
X
Yifeng
Zhou
Z
Wenqin
Yuan
Y
Ningning
Zhou
Z
Jiao
He
H
D000208:Acute Disease; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D041781:Jaundice, Obstructive / Q000188:drug therapy* / Q000401:mortality; D008168:Lung / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D008315:Malondialdehyde / Q000097:blood; D009569:Nitric Oxide / Q000097:blood; D010182:Pancreatic Diseases / Q000401:mortality / Q000517:prevention & control; D010195:Pancreatitis / Q000188:drug therapy* / Q000401:mortality; D028321:Plant Preparations / Q000494:pharmacology*; D011014:Pneumonia / Q000276:immunology / Q000401:mortality / Q000517:prevention & control*; D051381:Rats; D027561:Salvia miltiorrhiza; D012720:Severity of Illness Index; D013482:Superoxide Dismutase / Q000097:blood
D004365:Drugs, Chinese Herbal; D015850:Interleukin-6; D016209:Interleukin-8; D028321:Plant Preparations; D018799:Intercellular Adhesion Molecule-1; D009569:Nitric Oxide; D008315:Malondialdehyde; D013482:Superoxide Dismutase