Endometrial receptivity is preserved in Diethylstilbestrol-associated and other Müllerian anomalies: evidence from tubal embryo transfer.
OBJECTIVE
To report implantation and pregnancy rates following TET in women with anomalous uteri, and to compare these with previously reported rates following trans-cervical ET.


METHODS
Between 1995 and 2003, 12 TET procedures were performed in seven women with Müllerian anomalies. Tubal ET was performed via laparoscopy 48 h after standard IVF in 3 cycles in two patients, whereas in 9 cycles in five patients, TET was performed 24 h or 48 h following oocyte donation.


RESULTS
Of the seven patients, 5 (71%) had a history of 15 failed cycles with trans-cervical ET. The 12 TET procedures resulted in eleven clinical pregnancies (92%; 95% CI: 63, 99%). There were seven deliveries/ongoing pregnancies (58%; 95% CI: 27%, 85%).


CONCLUSIONS
We observed high implantation and ongoing pregnancy rates in women with Müllerian anomalies, suggesting that 1) endometrial receptivity in anomalous uteri is preserved, and 2) transfer efficiency is reduced but may be restored with the use of TET.
Mor
Eliran
E
Department of Obstetrics and Gynecology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA.
Landay
Melanie
M
Paulson
Richard J
RJ
D000328:Adult; D004054:Diethylstilbestrol / Q000009:adverse effects*; D010064:Embryo Implantation; D004624:Embryo Transfer / Q000379:methods*; D004717:Endometrium / Q000473:pathology / Q000502:physiology*; D004968:Estrogens, Non-Steroidal / Q000009:adverse effects; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000139:chemically induced / Q000473:pathology / Q000628:therapy*; D008875:Middle Aged; D009095:Mullerian Ducts / Q000473:pathology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate
D004968:Estrogens, Non-Steroidal; D004054:Diethylstilbestrol