title: Absence of the interstitial cells of Cajal in a child with chronic pseudoobstruction.
abstract: Absence or altered distribution of the interstitial cells of Cajal (ICCs) has been described in association with intestinal pseudoobstruction in adults. We report the first pediatric case with regional absence of ICCs in the distal small bowel and colon associated with intestinal pseudoobstruction. This report highlights that abnormalities of the ICCs in intestinal pseudoobstruction should be considered early in the diagnostic workup of children with intestinal pseudoobstruction.
authors.affiliation: Group for Improvement of Intestinal Function and Treatment (GIFT), The Hospital for Sick Children, Toronto, Canada M5G 1X8.
authors.forename: Marie-Chantal
authors.initials: MC
authors.lastname: Struijs
authors.forename: Ivan R
authors.initials: IR
authors.lastname: Diamond
authors.forename: Paul B
authors.initials: PB
authors.lastname: Pencharz
authors.forename: Kenneth T E
authors.initials: KT
authors.lastname: Chang
authors.forename: Sandra
authors.initials: S
authors.lastname: Viero
authors.forename: Jacob C
authors.initials: JC
authors.lastname: Langer
authors.forename: Paul W
authors.initials: PW
authors.lastname: Wales
mesh_terms: D015415:Biomarkers; D002454:Cell Differentiation; D002648:Child; D002908:Chronic Disease; D003106:Colon / Q000196:embryology / Q000473:pathology*; D003112:Colonic Pseudo-Obstruction / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D005769:Gastrointestinal Motility / Q000502:physiology; D006801:Humans; D007081:Ileostomy; D007082:Ileum / Q000196:embryology / Q000473:pathology*; D008297:Male; D059630:Mesenchymal Stem Cells / Q000166:cytology; D008648:Mesoderm / Q000196:embryology / Q000473:pathology; D009130:Muscle, Smooth / Q000294:innervation; D009197:Myenteric Plexus / Q000737:chemistry / Q000502:physiology; D010289:Parenteral Nutrition, Total; D019009:Proto-Oncogene Proteins c-kit / Q000032:analysis
chemical_list: D015415:Biomarkers; D019009:Proto-Oncogene Proteins c-kit