[Study on JAKs-STATs signal transduction in neonatal rats with PVL].
OBJECTIVE
To examine the changes of JAKs-STATs pathway in the subventricular zone and choroid plexus of neonatal rats with PVL.


METHODS
A PVL model was established by right common carotid artery ligation followed by 4 h 6% oxygen exposure in 2-day-rat, the neonatal rats performed a sham operation, without hypoxia-ischemia were used as the control grobp. The rats were sacrificed at 0 h, 3 h, 6 h, 12 h, 1 d, 3 d. 7 d of HI, and the brain tissues were collected, immunohistochemistry was applied to detect the expression of P-JAK2 and P-STAT3.


RESULTS
The expression levels of P-JAK2 and P-STAT3 increased significantly after HI, peaked at 1 d, and remained at a higher level than control until 7 days of HI, the difference was significant (P < 0.01).


CONCLUSIONS
HI resulted in the activation of JAKs-STATs pathway in the subventricular zone and choroid plexus, and this pathway might participated in the pathophysiological process of PVL.
Wang
Xi-ge
XG
Department of Pediatrics, West China Second Hospital, Sichuan University, Chengdu 610041, China.
Xiong
Ying
Y
Guo
Wen-jin
WJ
Mu
De-zhi
DZ
D000818:Animals; D000831:Animals, Newborn; D005260:Female; D020925:Hypoxia-Ischemia, Brain / Q000378:metabolism*; D053612:Janus Kinases / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D050791:STAT Transcription Factors / Q000378:metabolism*; D015398:Signal Transduction
D050791:STAT Transcription Factors; D053612:Janus Kinases