Study of cholesterol-lowering effect and safety of simvaglisin on rabbit model of hypercholesterolemia.
Using rabbit model of experimental hypercholesterolemia we showed that the hypocholesterolemic effect of simvaglisin, a complex preparation containing simvastatin and glycyrrhizic acid, in doses corresponding to 40, 66.5, and 100 mg/kg/day simvastatin is equal to the hypocholesterolemic effect of 200 mg/kg/day simvastatin alone. The total blood cholesterol decreased by 39, 36, 47, and 38% (p < 0.05), respectively, after 20-day course of the preparation. Myotoxicity of simvaglisin evaluated by serum creatine phosphokinase was lower than that of simvastatin. After 30-day treatment, this parameter was lower by 26, 24, and 29% (p < 0.05) than the corresponding parameter for simvastatin.
Ragino
Y I
YI
N. N. Vorozhtsov Institute of Organic Chemistry, Siberian Division of Russian Academy of Sciences. ragino@online.nsk.su
Vavilin
V A
VA
Salakhutdinov
N F
NF
Makarova
S I
SI
Stakhneva
E M
EM
Safronova
O G
OG
Nikitin
Y P
YP
Tolstikov
G A
GA
D000818:Animals; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D004195:Disease Models, Animal; D019695:Glycyrrhizic Acid / Q000627:therapeutic use*; D006937:Hypercholesterolemia / Q000188:drug therapy*; D008297:Male; D011817:Rabbits; D019821:Simvastatin / Q000627:therapeutic use*
D000924:Anticholesteremic Agents; C531004:simvaglyzin; D019695:Glycyrrhizic Acid; D002784:Cholesterol; D019821:Simvastatin; D003402:Creatine Kinase