Comparative phytochemical and biological analysis to detect the genuineness of substitutes of the plant Moovila in drug preparations.
Pseudarthria viscida is the preferred source of the raw drug Salaparni in Ayurvedic system of medicine, especially in the preparation of Dasamoolarishtam. Due to its scarcity, other trifoliate leguminous plants, particularly the species of Desmodium and Uraria are used as substitutes. The phytochemical and biological properties of these plants were analyzed to sort out the genuineness of the substitutes. Qualitative as well as quantitative chemical profiles obtained for P. viscida showed similarity to U. rufescens. In vitro antioxidant and in vivo gastroprotective assays carried out to determine the biological properties of the extracts revealed that the acetone extract of P. viscida inhibited the formation of hydroxyl, superoxide, nitric oxide radicals, and lipid peroxidation. The oral administration of P. viscida extract significantly reduced ethanol-induced gastric ulceration in mice. Even though more or less the same chemical profile was obtained for P. viscida and U. rufescens, only P. viscida exhibited significant biological properties.
Babu
T D
TD
Non-Wood Forest Products Discipline, Kerala Forest Research Institute, Peechi, Thrissur 680 653, Kerala, India.
Sasidharan
N
N
Vijayan
Fijesh P
FP
Padikkala
Jose
J
D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D007887:Fabaceae / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology; D005609:Free Radicals / Q000737:chemistry; D051379:Mice; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D028321:Plant Preparations / Q000737:chemistry* / Q000592:standards; D018517:Plant Roots / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D059808:Polyphenols; D012997:Solvents; D013261:Sterols / Q000737:chemistry / Q000494:pharmacology; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control
D000470:Alkaloids; D000975:Antioxidants; D005419:Flavonoids; D016166:Free Radical Scavengers; D005609:Free Radicals; D010636:Phenols; D010936:Plant Extracts; D028321:Plant Preparations; D059808:Polyphenols; D012997:Solvents; D013261:Sterols