title: Total synthesis of azumamide E and sugar amino acid-containing analogue.
abstract: An efficient and practical total synthesis of marine cyclic tetrapeptide, natural product azumamide E (1) is achieved via high-yielding reactions. The strategy also allowed us to synthesize the azumamide E-SAA (sugar amino acid) analogue (2), whose solution-phase NMR and biological activity studies were also carried out.
authors.affiliation: Organic Division-I, Indian Institute of Chemical Technology, Hyderabad, India 500 607. sriVaric@iict.res.in
authors.forename: Srivari
authors.initials: S
authors.lastname: Chandrasekhar
authors.forename: Chennamaneni Lohitha
authors.initials: CL
authors.lastname: Rao
authors.forename: Mallikanti
authors.initials: M
authors.lastname: Seenaiah
authors.forename: Police
authors.initials: P
authors.lastname: Naresh
authors.forename: Bharatam
authors.initials: B
authors.lastname: Jagadeesh
authors.forename: Dharani
authors.initials: D
authors.lastname: Manjeera
authors.forename: Arpita
authors.initials: A
authors.lastname: Sarkar
authors.forename: Manika Pal
authors.initials: MP
authors.lastname: Bhadra
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D002241:Carbohydrates / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D002241:Carbohydrates; D010456:Peptides, Cyclic; C534894:azumamide E