title: Plasma adiponectin: a predictor of coronary heart disease in hemodialysis patients--a Japanese prospective eight-year study.
abstract: OBJECTIVE
  Plasma adiponectin may play a protective role in the pathogenesis of cardiovascular disease in hemodialysis (HD) patients. We examined the effect of plasma adiponectin levels on the prognosis of the HD patients.
  
  
  METHODS
  68 HD patients (male:female = 38:30) were subjected to plasma adiponectin measurement in 1998 and followed up over 8 years.
  
  
  RESULTS
  Plasma adiponectin concentrations differed between male and female patients (9.3 vs. 15.7 microg/ml). The plasma adiponectin concentration as a whole was positively correlated with serum high-density lipoprotein cholesterol and negatively with serum creatinine and waist circumference. During an 8-year follow-up, the cardiac events occurred in 7 of 38 men and in 10 of 30 women. Cox's proportional hazard model analysis in a stepwise manner revealed that coronary heart disease (CHD) was associated with intact parathyroid hormone concentration, age, and the presence of diabetes in men whereas plasma adiponectin concentration was the most powerful single predictor in women. The impact of the plasma adiponectin concentration was strengthened by Kaplan-Meier survival analysis. In the group with a lower plasma adiponectin concentration, CHD events were significantly increased in men (p = 0.043) and in women (p = 0.007).
  
  
  CONCLUSIONS
  Plasma adiponectin concentration may predict CHD outcomes in HD patients.
authors.affiliation: Kidney Center, Toranomon Hospital, Teikyo University School of Medicine, Tokyo, Japan. ftakemoto-ind@umin.ac.jp
authors.forename: Fumi
authors.initials: F
authors.lastname: Takemoto
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Katori
authors.forename: Naoki
authors.initials: N
authors.lastname: Sawa
authors.forename: Junichi
authors.initials: J
authors.lastname: Hoshino
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Suwabe
authors.forename: Shohei
authors.initials: S
authors.lastname: Nakanishi
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Arai
authors.forename: Seiichi
authors.initials: S
authors.lastname: Fukuda
authors.forename: Kenzo
authors.initials: K
authors.lastname: Kodaka
authors.forename: Masaru
authors.initials: M
authors.lastname: Shimada
authors.forename: Chihiro
authors.initials: C
authors.lastname: Yamazaki
authors.forename: Keitaro
authors.initials: K
authors.lastname: Yokoyama
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Nakano
authors.forename: Tohru
authors.initials: T
authors.lastname: Funahashi
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Ubara
authors.forename: Akira
authors.initials: A
authors.lastname: Yamada
authors.forename: Kenmei
authors.initials: K
authors.lastname: Takaichi
authors.forename: Shunya
authors.initials: S
authors.lastname: Uchida
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000367:Age Factors; D000368:Aged; D015415:Biomarkers; D002423:Cause of Death; D008076:Cholesterol, HDL / Q000097:blood; D003327:Coronary Disease / Q000097:blood* / Q000453:epidemiology; D003404:Creatinine / Q000097:blood; D048909:Diabetes Complications / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan / Q000453:epidemiology; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D006435:Renal Dialysis; D012307:Risk Factors; D012737:Sex Factors; D055105:Waist Circumference
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D008076:Cholesterol, HDL; D003404:Creatinine