Efficient lipase-selective synthesis of dilauryl mannoses by simultaneous reaction-extraction system.
An efficient method for enzymatic-selective synthesis of dilauryl mannoses was developed using lipase-catalyzed condensation of D: -mannose and lauric acid in a simultaneous reaction-extraction system. The highest equilibrium conversion of diesters of 51% (1,6-diester: 14%; 3,6-diester: 18%; 4,6-diester: 19%) and the total conversion of mono and dilauryl mannoses of 76% were achieved at the n-hexane/acetonitrile ratio of 1:1, the molar ratio of lauric acid to mannose of 4:1, 60 g/l molecular sieves and 5 g/l lipase at 50 degrees C for 72 h in 15 ml SRE system. The new system will be important for the synthesis of dilauryl mannoses.
Zhang
Wenbin
W
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, People's Republic of China.
Wang
Yinjiao
Y
Hayat
Khizar
K
Zhang
Xiaoming
X
Shabbar
Abbas
A
Feng
Biao
B
Jia
Chengsheng
C
D001709:Biotechnology / Q000379:methods*; D007848:Laurates / Q000378:metabolism*; D008049:Lipase / Q000378:metabolism*; D008358:Mannose / Q000031:analogs & derivatives* / Q000378:metabolism*
D007848:Laurates; D008049:Lipase; D008358:Mannose