An efficient and general enantioselective synthesis of sphingosine, phythosphingosine, and 4-substituted derivatives.
A general and efficient protocol for the enantioselective synthesis of sphingosine, phythosphingosine, and 4-substituted derivatives was established. These compounds were obtained from a common intermediate prepared from butadiene monoepoxide by a synthetic sequence involving enantioselective allylic substitution, cross-metathesis, and dihydroxylation.
Llaveria
Josep
J
Departament de Química Analítica i Química Orgànica, Facultat de Química, Universitat Rovira i Virgili, 43007 Tarragona, Spain.
Díaz
Yolanda
Y
Matheu
M Isabel
MI
Castillón
Sergio
S
D006900:Hydroxylation; D015394:Molecular Structure; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D013110:Sphingosine