Toxic effect of an antitumor drug paclitaxel on morphofunctional characteristics of the liver in rats.
Single intravenous injection of paclitaxel to rats in a maximum tolerated dose of 4.6 mg/kg was accompanied by permanent structural and functional changes in the liver. The observed changes were typical of nonspecific reactive hepatitis: infiltration with lymphocytes and macrophages, pyknosis, and focal fatty degeneration of hepatocytes. Liver enzyme activity increased in blood plasma.
Ermolaeva
L A
LA
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
Dubskaya
T Yu
TY
Fomina
T I
TI
Vetoshkina
T V
TV
Gol'dberg
V E
VE
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000633:toxicity*; D015415:Biomarkers / Q000097:blood; D005260:Female; D022781:Hepatocytes / Q000166:cytology / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology*; D017239:Paclitaxel / Q000633:toxicity*; D051381:Rats
D000972:Antineoplastic Agents, Phytogenic; D015415:Biomarkers; D017239:Paclitaxel