title: A distribution of two SNPs in exon 10 of the FSHR gene among the women with a diminished ovarian reserve in Ukraine.
abstract: OBJECTIVE
  To evaluate the association between phenotype and follicle stimulating hormone receptor (FSHR) genotype in women with ovarian dysfunction and patients with "poor response" to gonadotropin stimulation of ovulation.
  
  
  METHODS
  FSHR gene SNPs were analyzed by PCR and RFLP. "Poor responders" (ovarian dysfunction) group and "good responders" group constituted the study group. Normo-ovulatory women who gave birth to naturally conceived children formed control groups: under 35 years of age (control I) and over 35 years of age (control II).
  
  
  RESULTS
  The frequency of Ala307-Ser680/Ala307-Ser680 genotype was significantly more prevalent in the ovarian dysfunction group (26%) compared to the control I (7.7%) (P < 0.001) and a "good responders" group (12.5%) (P < 0.05); and in a "poor responders" group (33.3%) compared to a "good responders" group (P < 0.05), control I (P < 0.001) and control II (17.5%) (P < 0.05).
  
  
  CONCLUSIONS
  Our data shows the prevalence of the Ala307-Ser680/ Ala307-Ser680 genotype in the both groups of patients. The finding should have impact on the delineation of stimulation protocols.
authors.affiliation: Department of Human Genomics, Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Kiev, Ukraine.
authors.forename: Ganna
authors.initials: G
authors.lastname: Livshyts
authors.forename: Svetlana
authors.initials: S
authors.lastname: Podlesnaja
authors.forename: Sergey
authors.initials: S
authors.lastname: Kravchenko
authors.forename: Iryna
authors.initials: I
authors.lastname: Sudoma
authors.forename: Ludmila
authors.initials: L
authors.lastname: Livshits
mesh_terms: D000328:Adult; D019943:Amino Acid Substitution; D005091:Exons; D005260:Female; D043373:Follicle Stimulating Hormone, Human / Q000627:therapeutic use; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology; D006080:Ovarian Follicle / Q000187:drug effects / Q000503:physiopathology*; D010062:Ovulation Induction; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D011962:Receptors, FSH / Q000235:genetics* / Q000378:metabolism; D014455:Ukraine
chemical_list: D043373:Follicle Stimulating Hormone, Human; D011962:Receptors, FSH