title: Microbial transformation of testosterone by Rhizopus stolonifer and Fusarium lini.
abstract: The microbial transformation of testosterone by the fungi Rhizopus stolonifer and Fusarium lini has been investigated for the first time. The bioconversion reactions observed from R. stolonifer included oxidation of a 17beta-hydroxyl group, a hydroxylation at equatorial 11alpha position, reduction of the double bond at C-4 with oxidation of the methylene at C-6 to the corresponding keto group, and lactonisation of ring D; the latter is the first report of this reaction by a Rhizopus species. Fusarium lini promoted 1-dehydrogenation of the steroid, which has been rarely observed in fungi cultures. The other routes of biotransformations included oxidation of the 17beta-hydroxyl group and the hydroxylation at 11alpha position. These reactions are not common for Fusarium species.
authors.affiliation: Chemistry Department, University of Jordan, Amman, Jordan. alaboudi@ju.edu.jo
authors.forename: Amal
authors.initials: A
authors.lastname: Al-Aboudi
authors.forename: Mohammad Yasin
authors.initials: MY
authors.lastname: Mohammad
authors.forename: S Ghulam
authors.initials: SG
authors.lastname: Musharraf
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.lastname: Atta-ur-Rahman
mesh_terms: D001711:Biotransformation; D005670:Fusarium / Q000378:metabolism*; D006900:Hydroxylation; D015394:Molecular Structure; D010084:Oxidation-Reduction; D012233:Rhizopus / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism*
chemical_list: D013739:Testosterone