title: Successful pregnancy after rituximab in a women with recurrent in vitro fertilisation failures and anti-phospholipid antibody positive.
abstract: We report a case of successful pregnancy after rituximab in a patient with a history of in vitro fertilisation (IVF) failures and positive anti-cardiolipin antibody (ACA). Following a course of rituximab, her ACA became negative and she successfully conceived with IVF treatment. This is the first case in literature describing the use of rituximab therapy in this clinical scenario.
authors.affiliation: Bone and Joint Unit, Department of Rheumatology, St Vincent’s University Hospital, Dublin, Ireland. chin.teck.ng@ucd.ie
authors.forename: C T
authors.initials: CT
authors.lastname: Ng
authors.forename: M
authors.initials: M
authors.lastname: O'Neil
authors.forename: D
authors.initials: D
authors.lastname: Walsh
authors.forename: T
authors.initials: T
authors.lastname: Walsh
authors.forename: D J
authors.initials: DJ
authors.lastname: Veale
mesh_terms: D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000187:drug effects / Q000378:metabolism*; D058846:Antibodies, Monoclonal, Murine-Derived / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology / Q000627:therapeutic use*; D007247:Infertility, Female / Q000188:drug therapy* / Q000276:immunology; D050498:Live Birth; D011247:Pregnancy; D000069283:Rituximab
chemical_list: D017153:Antibodies, Anticardiolipin; D058846:Antibodies, Monoclonal, Murine-Derived; D007155:Immunologic Factors; D000069283:Rituximab