title: Out-of-plane microtube arrays for drug delivery--liquid flow properties and an application to the nerve block test.
abstract: We have proposed fabricating very fine out-of-plane silicon-dioxide microtube arrays using a selective vapor-liquid-solid (VLS) growth technique and microfabrication processes. In this study, we elucidated the liquid-flow properties of microtubes with different inner diameters. Our fabricated microtubes were 0.5 microm in wall thickness; 20 microm in height; and either 2.5 microm, 4.1 microm, 4.6 microm, or 6.4 microm in inner diameter. We determined the relationship between the flow pressure and the liquid flow rate through the microtube. We also conducted a nerve block test, in which a microtube with 4.6 microm inner diameter was used to administer lidocaine solution (Na channel blocker) to the rat sciatic nerve. This successful test represents the first reported use of a microtube for drug delivery to the peripheral nerve of a rat. We conclude that the proposed microtube array and its fabrication process might contribute to developing pharmacological devices.
authors.affiliation: Department of Electrical and Electronic Engineering, Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi, Aichi, 441-8580, Japan. takei@dev.eee.tut.ac.jp
authors.forename: Kuniharu
authors.initials: K
authors.lastname: Takei
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kawashima
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kawano
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Kaneko
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Sawada
authors.forename: Makoto
authors.initials: M
authors.lastname: Ishida
mesh_terms: D000779:Anesthetics, Local / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D016503:Drug Delivery Systems; D004566:Electrodes; D004867:Equipment Design; D017408:Guidelines as Topic; D008012:Lidocaine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008855:Microscopy, Electron, Scanning; D055616:Microtechnology; D009407:Nerve Block; D010525:Peripheral Nerves / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000187:drug effects / Q000378:metabolism; D012822:Silicon Dioxide / Q000737:chemistry; D012834:Silver / Q000737:chemistry; D018030:Silver Compounds / Q000737:chemistry
chemical_list: D000779:Anesthetics, Local; D018030:Silver Compounds; D012834:Silver; D012822:Silicon Dioxide; D008012:Lidocaine; C037548:silver chloride