title: Diclofenac potassium attenuates dysmenorrhea and restores exercise performance in women with primary dysmenorrhea.
abstract: We assessed the efficacy of diclofenac potassium, a nonsteroidal anti-inflammatory drug, in alleviating menstrual pain and restoring exercise performance to that measured in the late-follicular phase of the menstrual cycle. Twelve healthy young women with a history of primary dysmenorrhea completed, in a random order, laboratory exercise-testing sessions when they were in the late-follicular (no menstruation, no pain) phase of the menstrual cycle and when they were experiencing dysmenorrhea and receiving, in a double-blinded fashion, either 100 mg of diclofenac potassium or placebo. We assessed the women's leg strength (1-repetition maximum test), aerobic capacity (treadmill walking test), and ability to perform a functional test (task-specific test). Compared with placebo, diclofenac potassium significantly decreased dysmenorrhea on the day of administration (Visual Analog Scale, P < .001 at all times). When receiving placebo for menstrual pain, the women's performance in the tests was decreased significantly, compared with when they were receiving diclofenac potassium for menstrual pain (P < .05) and compared with when they were in the late-follicular phase of the menstrual cycle (P < .05 for treadmill test, P < .01 for task-specific test and 1-repetition maximum test). Administration of diclofenac potassium for menstrual pain restored exercise performance to a level not different from that achieved in the late-follicular phase of the cycle.
  
  
  CONCLUSIONS
  In women with primary dysmenorrhea, menstrual pain, if untreated, decreases laboratory-assessed exercise performance. A recommended daily dose of a readily available nonsteroidal anti-inflammatory drug, diclofenac potassium, is effective in relieving menstrual pain and restoring physical performance to levels achieved when the women were in the late-follicular (no menstruation, no pain) phase of the menstrual cycle.
authors.affiliation: Brain Function Research Group, School of Physiology, University of Witwatersrand, Parktown, Johannesburg, South Africa. Ingrid.Chantler@wits.ac.za
authors.forename: Ingrid
authors.initials: I
authors.lastname: Chantler
authors.forename: Duncan
authors.initials: D
authors.lastname: Mitchell
authors.forename: Andrea
authors.initials: A
authors.lastname: Fuller
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000704:Analysis of Variance; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D004008:Diclofenac / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D004412:Dysmenorrhea / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D015444:Exercise / Q000523:psychology; D005260:Female; D006801:Humans; D008597:Menstrual Cycle / Q000187:drug effects*; D010807:Physical Endurance / Q000187:drug effects*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac