title: Xanthones from the seeds of Allanblackia monticola and their apoptotic and antiproliferative activities.
abstract: Phytochemical investigations of the seeds of ALLANBLACKIA MONTICOLA have led to the isolation and characterization of one new xanthone derivative, named allanxanthone E ( 1), together with seven known compounds, including five xanthones, 1,7-dihydroxy-3-methoxy-2-(3-methylbut-2-enyl)xanthone ( 2), alpha-mangostin ( 3) , garciniafuran ( 4) , allanxanthone C ( 5), and 1,6-dihydroxy-2,4-diprenylxanthone ( 6), and two pentacyclic triterpenes, friedelin and lupeol. The structures of these compounds were established on the basis of one- and two-dimensional NMR homo- and heteronuclear correlation evidence. Some of these compounds were evaluated for their apoptotic and antiproliferative activities against human leukemic B lymphocytes, such as the hairy cell leukemia-derived ESKOL cell line and cells from B-CLL (B-cell chronic lymphocytic leukemia) patients.
authors.affiliation: Department of Chemistry, Faculty of Science, University of Douala, Cameroon. azebaze@yahoo.com
authors.forename: Anatole Guy
authors.initials: AG
authors.lastname: Azebaze
authors.forename: Faouzia
authors.initials: F
authors.lastname: Menasria
authors.forename: Lylie Gwladys
authors.initials: LG
authors.lastname: Noumi
authors.forename: Edwige Laure
authors.initials: EL
authors.lastname: Nguemfo
authors.forename: Marie Fomani
authors.initials: MF
authors.lastname: Tchamfo
authors.forename: Augustin Ephrem
authors.initials: AE
authors.lastname: Nkengfack
authors.forename: Jean Pierre
authors.initials: JP
authors.lastname: Kolb
authors.forename: Michèle
authors.initials: M
authors.lastname: Meyer
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival; D028084:Clusiaceae / Q000737:chemistry*; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000188:drug therapy*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy*; D015394:Molecular Structure; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D012639:Seeds; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D044004:Xanthones; C539812:allanxanthone E