Inhaled nitric oxide and neuroprotection in preterm infants.
Although inhaled nitric oxide-mediated decreases in chronic lung disease and severe intraventricular hemorrhage/periventricular leukomalacia undoubtedly contribute to improved neurodevelopmental outcomes, inhaled nitric oxide has an independent neuroprotective effect. Although these data are encouraging, additional studies are required before recommending the routine use of inhaled nitric oxide for neuroprotection in preterm infants.
Marks
Jeremy D
JD
Department of Pediatrics, University of Chicago, Chicago, IL 60637, USA. jmarks@uchicago.edu
Schreiber
Michael D
MD
D000280:Administration, Inhalation; D002493:Central Nervous System Diseases / Q000517:prevention & control*; D006321:Heart / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008168:Lung / Q000187:drug effects; D009420:Nervous System / Q000187:drug effects / Q000254:growth & development; D018696:Neuroprotective Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D009569:Nitric Oxide / Q000008:administration & dosage* / Q000627:therapeutic use
D018696:Neuroprotective Agents; D009569:Nitric Oxide