[Granulocyte-colony stimulating factor producing tumor with high serum interleukin-6].
A 53-year-old man admitted to our hospital because of fever and chest abnormal shadow. Chest X-ray and computed tomography (CT) scan revealed large tumor on right upper lobe. Serum interleukin (IL)-6 and granulocyte-colony stimulating factor (G-CSF) were high. Right upper lobectomy and chest wall resection was performed. Histological diagnosis was large cell carcinoma. Immunohistological examination of lung tumor cells showed positive staining for G-CSF in only 1% of them. We diagnosed that tumor was G-CSF producing tumor and we thought that tumor produced IL-6.
Matsuda
E
E
Department of Chest Surgery, National Hospital Organization Sanyo Hospital, Ube, Japan.
Okabe
K
K
Yagi
T
T
Tao
H
H
Hirazawa
K
K
Murakami
T
T
Sugi
K
K
D018287:Carcinoma, Large Cell / Q000097:blood*; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008175:Lung Neoplasms / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000097:blood*
D015850:Interleukin-6; D016179:Granulocyte Colony-Stimulating Factor