Seroprevalence of human T lymphtropic virus (HTLV) among tissue donors in Iranian tissue bank.
Iranian Tissue Bank prepares a wide range of human tissue homografts such as; heart valve, bone, skin, amniotic membrane and other tissues for different clinical applications. The purpose of this study was to determine the seroprevalence of HTLV in tissue donors. About 1,548 tissue donors were studied during a 5-years period by ELISA assays. HTLV(1,2)-antibodies were tested for all of donors with other tests upon American Association of Tissue Banks (AATB) standards. About 25 (1.61%) out of 1,548 tissue donors were HTLV positive that 17 donors were male and 8 were female (female/male ratio was approximately 47%). Regarding to the prevalence of HTLV among tissue donors and importance of cell and tissue safety and quality assurance, we recommend that all blood, cell and tissue banks should be involved both routine serological methods and other complementary tests such as polymerase chain reaction (PCR) for diagnosis of HTLV.
Arjmand
Babak
B
Iranian Tissue Bank Research and Preparation Center & Brain and Spinal Injury Repair Research Center, Tehran University of Medical Sciences, Imam Khomeini Hospital, Keshavarz Blvd., Tehran, Iran. arjmand_itb@yahoo.com
Aghayan
Seyed Hamidreza
SH
Goodarzi
Parisa
P
Farzanehkhah
Mohammad
M
Mortazavi
Seyed Mohamadjavad
SM
Niknam
Mohamad Hossein
MH
Jafarian
Ali
A
Arjmand
Farzin
F
Jebelly far
Soheyla
S
D000328:Adult; D005260:Female; D015481:HTLV-I Antibodies / Q000097:blood*; D015482:HTLV-II Antibodies / Q000097:blood*; D015368:Human T-lymphotropic virus 1 / Q000276:immunology / Q000302:isolation & purification*; D015367:Human T-lymphotropic virus 2 / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies; D014015:Tissue Banks / Q000592:standards*; D014019:Tissue Donors
D015481:HTLV-I Antibodies; D015482:HTLV-II Antibodies