title: Development of a combined K-edge subtraction and fluorescence subtraction imaging system for small animals.
abstract: A novel combined imaging system for small animals using dilute concentrations of iodine as a contrast agent was developed for wide and pencil photon beam image acquisitions. This combined imaging system used K-edge subtraction (KES) and fluorescence subtraction imaging (FSI) and was tested at the Hard x-ray Microanalysis beamline at the Canadian Light Source. The initial wide beam KES image acquired with a charge-coupled device camera was used to identify regions of interest for further investigation and determine the location and area of the raster scan for pencil beam imaging. The pencil photon beam scanning mode acquired simultaneously KES and FSI measurements with an ionization chamber measuring the KES data and a multielement germanium detector measuring the FSI data. A description of the system is given as well as preliminary results using an iodine test object.
authors.affiliation: Department of Physics, University of Saskatchewan, 116 Science Place, Saskatoon, SK S7N 5E2, Canada.
authors.forename: Brian
authors.initials: B
authors.lastname: Bewer
authors.forename: Honglin
authors.initials: H
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhu
authors.forename: Limei
authors.initials: L
authors.lastname: Zhang
authors.forename: Graham N
authors.initials: GN
authors.lastname: George
authors.forename: Ingrid J
authors.initials: IJ
authors.lastname: Pickering
authors.forename: Dean
authors.initials: D
authors.lastname: Chapman
mesh_terms: D000818:Animals; D003287:Contrast Media; D005453:Fluorescence; D007455:Iodine; D019047:Phantoms, Imaging; D017785:Photons; D011856:Radiographic Image Enhancement / Q000379:methods*; D011877:Radionuclide Imaging; D013382:Subtraction Technique; D014963:X-Ray Intensifying Screens
chemical_list: D003287:Contrast Media; D007455:Iodine