title: Analytic solution during an infusion test of the linear unsteady poroelastic equations in a spherically symmetric model of the brain.
abstract: This work determines the spatial and temporal distribution of cerebrospinal fluid (CSF) pressure and brain displacement during an infusion test in a spherically symmetric model of the brain. The response of CSF pressure and parenchymal displacement to blood pressure pulsations is determined in the solution. We use a spherically symmetric, three-component poroelastic model of the brain, differentiating between the solid elastic matrix, the CSF and the arterial blood compartments. The governing equations are linearized with quasi-constant poroelastic parameters. The solution does reproduce the average intracranial pressure increase during the test as well as the rise in CSF pressure pulsation amplitude due to transmission of blood pressure oscillations. In addition, the CSF flux into and out of the parenchyma is shown over time.
authors.affiliation: Institute for Numerical Simulation, University of Bonn, Nussallee 15, 53113 Bonn, Germany.
authors.forename: Benedikt
authors.initials: B
authors.lastname: Wirth
authors.forename: Ian
authors.initials: I
authors.lastname: Sobey
mesh_terms: D000465:Algorithms; D001921:Brain / Q000187:drug effects* / Q000502:physiology / Q000503:physiopathology; D002555:Cerebrospinal Fluid / Q000502:physiology*; D015170:Cerebrospinal Fluid Pressure / Q000187:drug effects* / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology; D003187:Compliance / Q000187:drug effects* / Q000502:physiology; D003198:Computer Simulation; D004548:Elasticity / Q000502:physiology; D006801:Humans; D006849:Hydrocephalus / Q000503:physiopathology; D007278:Injections, Spinal; D019586:Intracranial Hypertension / Q000503:physiopathology; D007427:Intracranial Pressure / Q000187:drug effects / Q000502:physiology; D008954:Models, Biological; D016062:Porosity; D012212:Rheology; D012965:Sodium Chloride / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D012965:Sodium Chloride