Prevalence and genetic characterization of blaCTX-M among Klebsiella pneumoniae isolates collected in an intensive care unit in Brazil.
Thirteen (44.8%) CTX-M-2-producing K. pneumoniae clinical isolates were identified among 29 strains collected from single patients with serious infection hospitalized in an intensive care unit of a tertiary hospital located in São Paulo, Brazil. These isolates belonged to 9 different typing clusters and showed great diversity of plasmid content. Their bla(CTX-M-2)was carried in an ISCR1/sul1-type integron structure located in transferable plasmids of different sizes or in the chromosome.
Do Carmo Filho
J R
JR
Pontifícia Universidade Católica de Goiás, Goiás, Brazil.
Silva
R M
RM
Castanheira
M
M
Tognim
M C B
MC
Gales
A C
AC
Sader
H S
HS
D015139:Blotting, Southern; D001938:Brazil; D003428:Cross Infection / Q000453:epidemiology* / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D006801:Humans; D007362:Intensive Care Units; D007710:Klebsiella Infections / Q000453:epidemiology* / Q000235:genetics; D007711:Klebsiella pneumoniae / Q000235:genetics / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D010957:Plasmids; D016133:Polymerase Chain Reaction; D015995:Prevalence; D001618:beta-Lactamases / Q000235:genetics*
C071167:beta-lactamase CTX-2; D001618:beta-Lactamases