Monoclonality of composite large cell neuroendocrine carcinoma and mucinous epithelial tumor of the ovary: a case study.
A rare case of mixed carcinoma of the ovary is reported, composed of a large cell neuroendocrine carcinoma and a mucinous borderline endocervical tumor. The large cell neuroendocrine carcinoma was composed of solid nests, sheets, and trabeculae of medium to large-sized cells, and was positive for synaptophysin. The mucinous epithelial tumor varied in appearance from a borderline to an intraepithelial carcinoma, and showed sparsely scattered immunoreactivity for chromogranin-A. Using an X-chromosome clonality assay, these 2 components showed patterns of monoclonality. These results suggest that the large cell neuroendocrine carcinoma may have arisen from the mucinous epithelial tumor.
Yasuoka
Hironao
H
Department of Clinical Laboratory Medicine, Wakayama Medical University, Wakayama City, Wakayama, Japan.
Tsujimoto
Masahiko
M
Fujita
Shigeki
S
Kunishige
Ichiro
I
Nishio
Yukihiro
Y
Kodama
Rieko
R
Oishi
Hiroaki
H
Sanke
Tokio
T
Nakamura
Yasushi
Y
D002288:Adenocarcinoma, Mucinous / Q000235:genetics / Q000473:pathology*; D000328:Adult; D018287:Carcinoma, Large Cell / Q000235:genetics / Q000473:pathology*; D018278:Carcinoma, Neuroendocrine / Q000235:genetics / Q000473:pathology*; D002999:Clone Cells; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000235:genetics / Q000473:pathology*; D016133:Polymerase Chain Reaction; D011944:Receptors, Androgen / Q000235:genetics
D011944:Receptors, Androgen