Role of M3 receptor in aconitine/barium-chloride-induced preconditioning against arrhythmias in rats.
We demonstrated here that an initial treatment with aconitine- or barium-chloride-induced arrhythmias and resulted in reduced susceptibility of the heart to the induction of arrhythmias by a repeated drug treatment 24 h after the initial one, a delayed preconditioning cardioprotection. This delayed preconditioning was accompanied by enhanced expression of cardiac muscarinic M(3) receptor and abolished by M(3)-selective antagonist. We conclude that muscarinic M(3) receptors might play an important role in conferring the pharmacological preconditioning against arrhythmias. This study thus expands our understanding of the cellular function and pathophysiological roles of muscarinic M(3) receptor and reconsolidates our view of cardioprotective effects of muscarinic M(3) receptor on myocardium.
Liu
Yan
Y
Department of Pharmacology, Harbin Medical University, Harbin, 150081, People's Republic of China.
Du
Juan
J
Gao
Yang
Y
Zhang
Yong
Y
Cai
Ben-zhi
BZ
Zhao
Hua
H
Qi
Han-ping
HP
Du
Zhi-min
ZM
Lu
Yan-jie
YJ
Yang
Bao-feng
BF
D000157:Aconitine / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000378:metabolism / Q000517:prevention & control*; D017609:Barium Compounds / Q000494:pharmacology / Q000627:therapeutic use*; D002712:Chlorides / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D019157:Ischemic Preconditioning, Myocardial / Q000379:methods*; D008297:Male; D018727:Muscarinic Antagonists / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D043587:Receptor, Muscarinic M3 / Q000819:agonists / Q000037:antagonists & inhibitors / Q000502:physiology*; D013997:Time Factors
D017609:Barium Compounds; D002712:Chlorides; D018727:Muscarinic Antagonists; D043587:Receptor, Muscarinic M3; C024986:barium chloride; D000157:Aconitine