title: Molecular pathology of thyroid cancer: diagnostic and clinical implications.
abstract: There is now a reasonably good understanding of the key oncogenic events involved in the initiation and progression of thyroid cancer. Many of these are characteristic of certain tumor types, and their presence conveys diagnostic and prognostic information. It is not yet clear how this information will be applied to clinical practice. Based on preclinical evidence, mutations of genes encoding certain kinases may also predict response to specific tyrosine kinase inhibitors, although this has not yet been explored systematically in clinical trials.
authors.affiliation: Department of Medicine and Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA. faginj@mskcc.org
authors.forename: James A
authors.initials: JA
authors.lastname: Fagin
authors.forename: Nicholas
authors.initials: N
authors.lastname: Mitsiades
mesh_terms: D018265:Carcinoma, Papillary, Follicular / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D006801:Humans; D051059:PTEN Phosphohydrolase / Q000235:genetics; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics; D051096:Proto-Oncogene Proteins c-ret / Q000235:genetics; D013964:Thyroid Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D018631:ras Proteins / Q000235:genetics
chemical_list: D019869:Phosphatidylinositol 3-Kinases; D051096:Proto-Oncogene Proteins c-ret; C099282:RET protein, human; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf; D051059:PTEN Phosphohydrolase; D018631:ras Proteins