Preparation and in vitro evaluation of a new fentanyl patch based on acrylic/silicone pressure-sensitive adhesive blends.
In this study, the influence of the ratio of silicone (Si) to acrylic pressure-sensitive adhesive (PSA), polyvinyl pyrrolidone (PVP), and lauryl alcohol (LA) % (wt/wt) on the properties of a drug in adhesive patch containing 4% (wt/wt) fentanyl as model drug was evaluated. The dependent variables selected were drug solubility, in vitro drug release in the platforms as well as adhesion properties including peel strength and tack value. By using the central composite design of Design Expert software, it was found that the effect of each factor was different, yet all had influenced dependent variables significantly (p < .05). Quadratic model generated for various response variables using backward regression analysis was found to be statistically significant (p < .05). It was deduced that the presence of PVP and Si displayed similar trends on drug solubility and release. Each role played by Si with LA and PVP in release rate was separately investigated, and it was found that the presence of PVP and LA in lowering the amount of drug released was more dominant compared with that of Si. The release patterns at the early and later stages follow the Higuchi and semiempirical models, respectively. Effect of PVP as well as Si and LA were similar on tack value. The influence of LA compared to peeling characteristics of Si system was more pronounced.
Taghizadeh
Seyed Mojtaba
SM
Novel Drug Delivery Systems, Faculty of Science, Iran Polymer and Petrochemical Institute, Tehran, Islamic Republic of Iran.
Soroushnia
Arezou
A
Mirzadeh
Hamid
H
Barikani
Mehdi
M
D000179:Acrylates / Q000737:chemistry*; D000269:Adhesives / Q000737:chemistry*; D000279:Administration, Cutaneous; D000701:Analgesics, Opioid / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D003692:Delayed-Action Preparations; D004058:Diffusion; D007851:Dodecanol / Q000737:chemistry; D016503:Drug Delivery Systems; D005283:Fentanyl / Q000737:chemistry*; D007700:Kinetics; D008422:Materials Testing; D011090:Polyenes / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D011205:Povidone / Q000737:chemistry; D012828:Silicones / Q000737:chemistry*; D012995:Solubility
D000179:Acrylates; D000269:Adhesives; D000701:Analgesics, Opioid; D003692:Delayed-Action Preparations; D011090:Polyenes; D011108:Polymers; D012828:Silicones; D007851:Dodecanol; C008967:polyisobutylene; D011205:Povidone; D005283:Fentanyl