title: Necrotising scleritis and connective tissue disease--three cases and a review.
abstract: Necrotising scleritis is a severe form of anterior scleritis which is known to be associated with connective tissue disease but has not previously been reported in association with limited scleroderma. It is often a difficult condition to treat and without adequate early intervention leads to significant morbidity including visual loss. We report three cases of necrotising scleritis, two occurring in the context of previously unreported associations and a third case to compare presentation of the condition and highlight difficulties in management.
authors.affiliation: Academic Unit of Musculoskeletal Medicine, Department of Rheumatology, Leeds Teaching Hospitals NHS Trust, Chapel Allerton Hospital, Chapeltown Road, Leeds LS74SA, UK. s.nizam@leeds.ac.uk
authors.forename: Sharmin
authors.initials: S
authors.lastname: Nizam
authors.forename: Annette
authors.initials: A
authors.lastname: Johnstone
authors.forename: Michael
authors.initials: M
authors.lastname: Green
authors.forename: Andrew
authors.initials: A
authors.lastname: Gough
mesh_terms: D000369:Aged, 80 and over; D000869:Anterior Eye Segment / Q000473:pathology; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D014890:Granulomatosis with Polyangiitis / Q000097:blood / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008875:Middle Aged; D015423:Scleritis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D045745:Scleroderma, Limited / Q000150:complications* / Q000188:drug therapy / Q000473:pathology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D005938:Glucocorticoids; D007166:Immunosuppressive Agents