title: Risk prediction scores for postoperative mortality after esophagectomy: validation of different models.
abstract: BACKGROUND
  Different prediction models for operative mortality after esophagectomy have been developed. The aim of this study is to independently validate prediction models from Philadelphia, Rotterdam, Munich, and the ASA.
  
  
  METHODS
  The scores were validated using logistic regression models in two cohorts of patients undergoing esophagectomy for cancer from Switzerland (n = 170) and Australia (n = 176).
  
  
  RESULTS
  All scores except ASA were significantly higher in the Australian cohort. There was no significant difference in 30-day mortality or in-hospital death between groups. The Philadelphia and Rotterdam scores had a significant predictive value for 30-day mortality (p = 0.001) and in-hospital death (p = 0.003) in the pooled cohort, but only the Philadelphia score had a significant prediction value for 30-day mortality in both cohorts. Neither score showed any predictive value for in-hospital death in Australians but were highly significant in the Swiss cohort. ASA showed only a significant predictive value for 30-day mortality in the Swiss. For in-hospital death, ASA was a significant predictor in the pooled and Swiss cohorts. The Munich score did not have any significant predictive value whatsoever.
  
  
  CONCLUSIONS
  None of the scores can be applied generally. A better overall predictive score or specific prediction scores for each country should be developed.
authors.affiliation: Flinders University Department of Surgery, Flinders Medical Center, Flinders Drive, Bedford Park, Adelaide, 5042, South Australia, Australia. uzingg@uhbs.ch
authors.forename: U
authors.initials: U
authors.lastname: Zingg
authors.forename: C
authors.initials: C
authors.lastname: Langton
authors.forename: B
authors.initials: B
authors.lastname: Addison
authors.forename: B P L
authors.initials: BP
authors.lastname: Wijnhoven
authors.forename: J
authors.initials: J
authors.lastname: Forberger
authors.forename: S K
authors.initials: SK
authors.lastname: Thompson
authors.forename: A J
authors.initials: AJ
authors.lastname: Esterman
authors.forename: D I
authors.initials: DI
authors.lastname: Watson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001315:Australia / Q000453:epidemiology; D004935:Esophageal Diseases / Q000401:mortality / Q000601:surgery; D016629:Esophagectomy / Q000401:mortality*; D005260:Female; D006305:Health Status Indicators; D017052:Hospital Mortality; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012121:Respiration, Artificial; D018570:Risk Assessment; D018709:Statistics, Nonparametric; D013557:Switzerland / Q000453:epidemiology
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase