title: Modulation of macrophage functions by compounds isolated from Zingiber officinale.
abstract: Bioactivity-guided fractionation of Zingiber Officinale (zingiberaceae) led us to isolate 14 compounds, -gingerol ( 1), -gingerol ( 2), -gingerol ( 3), -gingerol ( 4), -paradol ( 5), -shogaol ( 6), -shogaol ( 7), 1-dehydro- -gingerdione ( 8), -gingerdione ( 9), hexahydrocurcumin ( 10), tetrahydrocurcumin ( 11), gingerenone A ( 12), 1,7-bis-(4' hydroxyl-3' methoxyphenyl)-5-methoxyhepthan-3-one ( 13), and methoxy- -gingerol ( 14). Using the RAW 264.7 cell line, the inhibitory effects on nitric oxide production induced by lipopolysaccharide and the stimulatory effects on phagocytosis of these compounds were evaluated. Compounds 7, 8, and 9 significantly decreased lipopolysaccharide-induced nitric oxide production, and compounds 7 and 8 significantly reduced inducible nitric oxide synthase expression. Among them, compound 8 also showed significant stimulatory effects on phagocytosis.
authors.forename: Eun Mi
authors.initials: EM
authors.lastname: Koh
authors.forename: Hye Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Sohee
authors.initials: S
authors.lastname: Kim
authors.forename: Woo Hyuck
authors.initials: WH
authors.lastname: Choi
authors.forename: Yeon Hee
authors.initials: YH
authors.lastname: Choi
authors.forename: Shi Yong
authors.initials: SY
authors.lastname: Ryu
authors.forename: Young Sup
authors.initials: YS
authors.lastname: Kim
authors.forename: Woo Suk
authors.initials: WS
authors.lastname: Koh
authors.forename: Shin-Young
authors.initials: SY
authors.lastname: Park
mesh_terms: D000818:Animals; D002396:Catechols / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D036381:Diarylheptanoids / Q000737:chemistry / Q000494:pharmacology; D005233:Fatty Alcohols / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D020939:Zingiber officinale / Q000737:chemistry*; D006139:Guaiacol / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects*; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis*; D052247:Nitric Oxide Synthase Type II / Q000037:antagonists & inhibitors; D010587:Phagocytosis / Q000187:drug effects*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D002396:Catechols; D036381:Diarylheptanoids; D005233:Fatty Alcohols; D008070:Lipopolysaccharides; D010936:Plant Extracts; C000604237:gingerenone A; D009569:Nitric Oxide; D006139:Guaiacol; C040115:shogaol; C007845:gingerol; D052247:Nitric Oxide Synthase Type II; C050872:gingerdione