title: Association of macroscopic gut inflammation with disease activity, functional status and quality of life in ankylosing spondylitis.
abstract: The aim of this cross-sectional study was to evaluate the frequency of intestinal inflammation and its association with disease activity, functional status and quality of life in patients with ankylosing spondylitis (AS). A total of 25 patients with AS had undergone ileocolonoscopy and concomitant histological study. Clinical and demographical parameters, BASDAI, BASFI, and SF-36 scores were compared between patients with and without macroscopic gut inflammation (MGI). Colonoscopic study revealed MGI in 9 patients and macroscopically normal gut mucosa in 16 patients. On histological examination, of 25 patients 20 had gut inflammation, mostly in ileum. BASDAI score was higher (P < 0.05), SF-36 pain and physical scores, and chest expansion measurement were lower (P = 0.00, P = 0.01, P = 0.01), duration of morning stiffness was longer (P = 0.01) in patients with MGI. Serum C-reactive protein, erytrocyte sedimentation rate levels were similar between groups (P > 0.05). There is high prevalence of histological gut inflammation in AS patients. More active disease should suggest gut inflammation in AS patients.
authors.affiliation: Ataturk Training and Research Hospital, Izmir, Turkey.
authors.forename: Gulen
authors.initials: G
authors.lastname: Hascelik
authors.forename: Bengi
authors.initials: B
authors.lastname: Oz
authors.forename: Nese
authors.initials: N
authors.lastname: Olmez
authors.forename: Asuman
authors.initials: A
authors.lastname: Memis
authors.forename: Gazi
authors.initials: G
authors.lastname: Yoruk
authors.forename: Belkis
authors.initials: B
authors.lastname: Unsal
authors.forename: Nese
authors.initials: N
authors.lastname: Ekinci
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis / Q000378:metabolism; D003106:Colon / Q000473:pathology* / Q000503:physiopathology; D003113:Colonoscopy; D015897:Comorbidity; D017281:Cost of Illness; D003430:Cross-Sectional Studies; D004185:Disability Evaluation; D004760:Enterocolitis / Q000175:diagnosis* / Q000453:epidemiology* / Q000523:psychology; D005260:Female; D006801:Humans; D007082:Ileum / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D015995:Prevalence; D011788:Quality of Life; D012131:Respiratory Insufficiency / Q000453:epidemiology / Q000503:physiopathology; D013167:Spondylitis, Ankylosing / Q000453:epidemiology* / Q000523:psychology
chemical_list: D002097:C-Reactive Protein