Citreamicins with potent gram-positive activity.
Two new xanthone antibiotics, citreamicin delta (1) and epsilon (2), with potent activity against Gram-positive pathogens including multidrug-resistant Staphylococcus aureus (MDRSA) were discovered. Compounds 1 and 2 exhibited MIC values < 1 microg/mL versus a number of resistant strains. The compounds were obtained from EtOAc extracts of Streptomyces vinaceus and were purified by countercurrent chromatography and reversed-phase HPLC. Their structures were elucidated using primarily NMR and mass spectroscopy.
Hopp
D Craig
DC
AMRI, Bothell Research Center, 18804 North Creek Parkway, Bothell, Washington 98011, USA.
Milanowski
Dennis J
DJ
Rhea
Joshua
J
Jacobsen
Daniel
D
Rabenstein
John
J
Smith
Chris
C
Romari
Khadidja
K
Clarke
Midori
M
Francis
Linda
L
Irigoyen
Macarena
M
Luche
Michele
M
Carr
Grant J
GJ
Mocek
Ulla
U
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D010080:Oxazoles; C534409:citreamicin delta; C534408:citreamicin epsilon