[Th17 cells, a novel proinflammatory effector CD4 T cell population].
After more than 20 years of hegemony, the Th1-Th2 paradigm was recently shaken by the discovery of a novel population of CD4 effector T cells, the Th17 cells. Th17 effector cells produce IL-17 and IL-22 and thus have pro-inflammatory properties notably favoring neutrophils recruitment and thus control of extracellular bacteria mainly at the epithelium surface. Th17 cells appear also as the major inducer of organ specific autoimmune pathologies such as EAE or rheumatoid arthritis, a function previously attributed to Th1 effector cells. The discovery of Th17 cells further supports the notion that effector CD4 T cells responses are diverse in vivo and that fine tuning of these different effector cells is critical to maintain tissue integrity.
Leung-Theung-Long
Stéphane
S
Inserm, U563, Université Toulouse III Paul-Sabatier, Centre de Physiopathologie de Toulouse Purpan, CHU Purpan, Bâtiment A, BP 3028, Place du Docteur Baylac, 31024 Toulouse Cedex, France. stephane.leung-theung-long@inserm.fr
Guerder
Sylvie
S
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D051379:Mice; D023421:Models, Animal; D009504:Neutrophils / Q000276:immunology / Q000502:physiology; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*