title: Cancer stem cell marker expression in hepatocellular carcinoma and liver metastases is not sufficient as single prognostic parameter.
abstract: Recent findings suggest that the presence of cancer stem cells could be linked with patients' survival. We profiled suggested cancer stem cell markers in tissue specimens of hepatocellular carcinoma and colorectal carcinoma liver metastases. About 1% of cells co-expressed cancer stem cell antigens, but there was no correlation between the amount of CD133(+), CD133(+)/CD44(+) or CD133(+)/CD24(-) cells and the patients' clinical-pathological status or with the cancer stem cell marker-positive cells localization. CD133(+) and CD133(-) fractions of Huh7 cells did not differ in migratory properties. Therefore, presence of markers alone should be taken with caution as single prognostic parameters.
authors.affiliation: Molecular OncoSurgery Group, University of Heidelberg and German Cancer Research Center, Im Neuenheimer Feld 365, Heidelberg, Germany.
authors.forename: Alexei V
authors.initials: AV
authors.lastname: Salnikov
authors.forename: Grace
authors.initials: G
authors.lastname: Kusumawidjaja
authors.forename: Vanessa
authors.initials: V
authors.lastname: Rausch
authors.forename: Helge
authors.initials: H
authors.lastname: Bruns
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Gross
authors.forename: Akmal
authors.initials: A
authors.lastname: Khamidjanov
authors.forename: Eduard
authors.initials: E
authors.lastname: Ryschich
authors.forename: Martha-Maria
authors.initials: MM
authors.lastname: Gebhard
authors.forename: Gerhard
authors.initials: G
authors.lastname: Moldenhauer
authors.forename: Markus W
authors.initials: MW
authors.lastname: Büchler
authors.forename: Peter
authors.initials: P
authors.lastname: Schemmer
authors.forename: Ingrid
authors.initials: I
authors.lastname: Herr
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism*; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000473:pathology / Q000556:secondary; D015179:Colorectal Neoplasms / Q000473:pathology; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D016130:Immunophenotyping; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000556:secondary; D008297:Male; D008875:Middle Aged; D014411:Neoplastic Stem Cells / Q000276:immunology / Q000378:metabolism*; D011379:Prognosis
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor