Polymorphisms of detoxification and DNA repair enzymes in myelodyplastic syndromes.
The genetic background may modify the individual's risk of developing cancer. We performed a case-control study to test the impact of genomic polymorphisms of 9 genes involved in xenobiotics detoxification and DNA repair in myelodysplastic syndromes (MDS). Frequencies of polymorphic variants of RAD51, XRCC3, NQO1, GSTA1, GSTM1, GSTT1, CYP3A4 and XPD enzymes were similar in patients and controls. On the other hand, the GSTP1-105Val allele was associated to an increased risk of MDS (O.R. 1.66; p=0.04) and to higher probability of overall survival in the low/intermediate-1 IPSS risk group (p=0.008). The GSTP1-Ile105Val polymorphism is likely to influence MDS risk and prognosis.
Fabiani
Emiliano
E
Istituto di Ematologia, Università Cattolica del Sacro Cuore, L go A Gemelli, Rome, Italy.
D'Alò
Francesco
F
Scardocci
Alessandra
A
Greco
Mariangela
M
Di Ruscio
Annalisa
A
Criscuolo
Marianna
M
Fianchi
Luana
L
Pagano
Livio
L
Hohaus
Stefan
S
Leone
Giuseppe
G
Voso
Maria Teresa
MT
D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D015331:Cohort Studies; D004260:DNA Repair / Q000235:genetics*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D009190:Myelodysplastic Syndromes / Q000235:genetics* / Q000401:mortality; D011110:Polymorphism, Genetic; D012307:Risk Factors; D015996:Survival Rate; D015262:Xenobiotics
D015262:Xenobiotics