title: Regulating the motor for GLUT4 vesicle traffic.
abstract: Insulin-triggered trafficking of GLUT4 glucose transporter-loaded vesicles and their fusion with the plasma membrane are mechanical processes involving multiprotein complexes that coordinate and facilitate vesicle movement. Now, Yip et al. (2008) link myosin-1c to insulin signaling by demonstrating direct CaMKII-driven phosphorylation of this critical motor protein.
authors.affiliation: Department of Biology and Biochemistry, University of Bath, Bath, UK. g.d.holman@bath.ac.uk
authors.forename: Geoffrey D
authors.initials: GD
authors.lastname: Holman
authors.forename: Kei
authors.initials: K
authors.lastname: Sakamoto
mesh_terms: D048948:14-3-3 Proteins / Q000378:metabolism; D000818:Animals; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Q000502:physiology*; D002462:Cell Membrane / Q000378:metabolism; D051275:Glucose Transporter Type 4 / Q000378:metabolism*; D007328:Insulin / Q000502:physiology*; D008561:Membrane Fusion / Q000502:physiology*; D051379:Mice; D024461:Myosin Type I; D009218:Myosins / Q000378:metabolism*; D010766:Phosphorylation; D021381:Protein Transport; D015398:Signal Transduction; D022161:Transport Vesicles / Q000502:physiology*
chemical_list: D048948:14-3-3 Proteins; D051275:Glucose Transporter Type 4; D007328:Insulin; C470422:Myo1c protein, mouse; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D024461:Myosin Type I; D009218:Myosins