Derivation of a new equation for estimating creatinine clearance by using fat-free mass and serum creatinine concentration in Korean patients with type 2 diabetes mellitus.
OBJECTIVE
Equations to predict creatinine clearance (Ccr) or glomerular filtration rate have limitations in applying to a wide range of ethnicities with different fat-free mass (FFM). We aimed to determine the serum creatinine (Scr) concentrations that indicate renal insufficiency and formulate a new equation to estimate Ccr by a function of FFM in Korean type 2 diabetic patients.


METHODS
Ccr was measured in 283 type 2 diabetic patients by 24-h urine collection. Receiver operating characteristic (ROC) curve was used to determine the Scr concentration corresponding to a Ccr of 60 mL min(-1) x 1.73 m(-2). A new equation to predict Ccr was derived by using Scr and FFM.


RESULTS
The Scr concentration corresponding to a Ccr of 60 mL min(-1) x 1.73 m(-2) was 1.15 mg/dL in men and 0.95 mg/dL in women. The regression equation estimating the Ccr was expressed as (1.72 x FFM-0.23 x age)/Scr, and it showed a good correlation with the measured Ccr (r=0.718, P<0.001).


CONCLUSIONS
Scr concentrations indicating renal insufficiency in the Korean patients were considerably lower than those in Caucasians. The equation derived in this study would be more useful in Korean or other Asian type 2 diabetic patients.
Lee
Eun Kyung
EK
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Cho
Young Min
YM
Kim
Jin Taek
JT
Koo
Bo Kyung
BK
Cho
Hwa Young
HY
Ku
Yun Hyi
YH
Park
Kyong Soo
KS
Jang
Hak Chul
HC
Kim
Seong Yeon
SY
Lee
Hong Kyu
HK
D000368:Aged; D044466:Asian People; D003404:Creatinine / Q000097:blood* / Q000652:urine*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000208:ethnology / Q000628:therapy / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D051437:Renal Insufficiency / Q000097:blood / Q000453:epidemiology / Q000652:urine; D044465:White People
D003404:Creatinine