Antithrombogenic and antiplatelet activity of optho-isobornyl phenol derivative.
We studied antithrombogenic and antiplatelet properties of 4-methyl-2,6-diisobornyl phenol, a new promising compound belonging to ortho-isobornyl phenol derivatives, under conditions of intravascular thrombosis and acute cerebral ischemia. It was found that 4-methyl-2,6-diisobornyl phenol prevents intravascular thrombus formation by reducing platelet aggregation and improving antiplatelet activity of the vascular wall.
Plotnikov
M B
MB
Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences.
Smolyakova
V I
VI
Ivanov
I S
IS
Kuchin
A V
AV
Chukicheva
I J
IJ
Krasnov
E A
EA
D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy; D001892:Camphanes / Q000494:pharmacology*; D003408:Cresols / Q000494:pharmacology*; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D008297:Male; D010431:Pentoxifylline / Q000627:therapeutic use; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013927:Thrombosis / Q000188:drug therapy
C533990:4-methyl-2,6-diisobornylphenol; D001892:Camphanes; D003408:Cresols; D005343:Fibrinolytic Agents; D010975:Platelet Aggregation Inhibitors; D010431:Pentoxifylline