Prevalence and clinical correlates of microalbuminuria in newly diagnosed hypertensive subjects.
BACKGROUND
Microalbuminuria has been found to be associated with some cardiovascular risk factors in both diabetic and hypertensive non diabetic patients.


METHODS
One hundred and five newly diagnosed drug naïve hypertensive patients were recruited after excluding subjects who had clinical proteinuria, evidence of renal disease (GFR < 60 mls/min) and diabetes. Microalbuminuria was detected in freshly voided early morning urine with Micral strips.


RESULTS
Prevalence microalbuminuria was found in 41% of the population studied and 32.7% of males and 48.2% of females. There was a trend towards increased levels of metabolic and non-metabolic cardiovascular risk factors among subjects who had microalbuminuria. Uric acid (OR = 1.74, p = 0.02), triglyceride (OR =1.004, p = 0.02), and FBS (OR = 1.64, p = 0.04) were significant determinants of microalbuminuria Subjects who had microalbuminuria were more likely to have LVH (OR = 8.02, p < 0.001) and hypertensive retinal changes(OR = 11.62, P < 0.001).


CONCLUSIONS
Microalbuminuria is associated with increasing levels of cardiovascular risk factors and development of target organ damage in hypertensive patients.
Odili
A N
AN
odilimercy@yahoo.com
D000418:Albumins; D000419:Albuminuria / Q000453:epidemiology* / Q000503:physiopathology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D016017:Odds Ratio; D015995:Prevalence; D012307:Risk Factors
D000418:Albumins