Cardioprotective effect of histidine-containing dipeptides in pharmacological cold cardioplegia.
The cardioprotective effect of cardioplegic solution based on histidine-containing dipeptides was evaluated on isolated rat heart under conditions of hyporthermia and long ischemia. The use of natural dipeptides in cardioplegic solutions promoted an increase in the buffer capacity of myocardial cells and creation of an additional anti-ischemic effect under conditions of long ischemia and hypothermia.
Bokeriya
L A
LA
A. N. Bakulev Institute of Cardiovascular Surgery, Russian Academy of Medical Sciences, Moscow.
Boldyrev
A A
AA
Movsesyan
R R
RR
Alikhanov
S A
SA
Arzumanyan
E S
ES
Nisnevich
E D
ED
Artyukhina
T V
TV
Serov
R A
RA
D000818:Animals; D002314:Cardioplegic Solutions / Q000494:pharmacology; D002316:Cardiotonic Agents / Q000494:pharmacology*; D002336:Carnosine / Q000031:analogs & derivatives / Q000494:pharmacology; D003080:Cold Temperature; D004151:Dipeptides / Q000494:pharmacology*; D007036:Hypothermia, Induced; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D002314:Cardioplegic Solutions; D002316:Cardiotonic Agents; D004151:Dipeptides; C033681:N-acetylcarnosine; D002336:Carnosine