title: Transitions in and out of alcohol use disorders: their associations with conditional changes in quality of life over a 3-year follow-up interval.
abstract: OBJECTIVE
  The aim of this study was to investigate longitudinal changes in quality of life (QOL) as a function of transitions in alcohol use disorders (AUD) over a 3-year follow-up of a general US population sample.
  
  
  METHODS
  The analysis is based on individuals who drank alcohol in the year preceding the Wave 1 National Epidemiologic Survey on Alcohol and Related Conditions and were reinterviewed at Wave 2 (n = 22,245). Using multiple linear regression models, changes in SF-12 QOL were estimated as a function of DSM-IV AUD transitions, controlling for baseline QOL and multiple potential confounders.
  
  
  RESULTS
  Onset and offset of AUD were strongly associated with changes in mental/psychological functioning, with significant decreases in mental component summary (NBMCS) scores among individuals who developed dependence and significant increases among those who achieved full and partial remission from dependence. The increases in overall NBMCS and its social functioning, role emotional and mental health components were equally great for abstinent and nonabstinent remission from dependence, but improvements in bodily pain and general health were associated with nonabstinent remission only. Onset of abuse was unrelated to changes in QOL, and the increase in NBMCS associated with nonabstinent remission from abuse only was slight. Individuals with abuse only or no AUD who stopped drinking had significant declines in QOL.
  
  
  CONCLUSIONS
  These results suggest the possible importance of preventing and treating AUD for maintaining and/or improving QOL. They are also consistent with the sick quitter hypothesis and suggest that abuse is less a mental disorder than a maladaptive pattern of behavior.
authors.affiliation: Laboratory of Biometry and Epidemiology, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892-9304, USA. ddawson@mail.nih.gov
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Dawson
authors.forename: Ting-Kai
authors.initials: TK
authors.lastname: Li
authors.forename: S Patricia
authors.initials: SP
authors.lastname: Chou
authors.forename: Bridget F
authors.initials: BF
authors.lastname: Grant
mesh_terms: D000293:Adolescent; D000328:Adult; D000437:Alcoholism / Q000453:epidemiology / Q000523:psychology*; D005260:Female; D005500:Follow-Up Studies; D006304:Health Status; D006306:Health Surveys; D006801:Humans; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D015233:Models, Statistical; D010146:Pain / Q000150:complications / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life; D015203:Reproducibility of Results; D013695:Temperance