A new cytotoxic friedelane acid--pluricostatic acid--and other compounds from the leaves of Marila pluricostata.
Bioassay-guided fractionation of the dichloromethane extract of the leaves of Marila pluricostata led to the isolation of 2alpha,3beta-dihydroxy-D:A-friedoolean-28-oic acid (pluricostatic acid), a new friedelane triterpenoid, (1), ten known triterpenoids and three sterols. Their chemical structures were elucidated through spectroscopic analysis. The less polar fractions, on GC/MS analysis and comparison with a MS library, resulted in the identification of twenty four sesquiterpenoids. The new triterpenoid acid 1 showed cytotoxicity against the MCF-7, H-460, and SF-268 human cancer cell lines with GI(50) values from 1.2 to 3.3 microg/mL.
Olmedo
Dionisio A
DA
Centro de Investigaciones Farmacognósticas de la Flora Panameña, Facultad de Farmacia, Universidad de Panamá, Apartado 0824-00172, Panamá, República de Panamá.
López-Pérez
José L
JL
del Olmo
Esther
E
Vásquez
Yelkaira
Y
San Feliciano
Arturo
A
Gupta
Mahabir P
MP
D045744:Cell Line, Tumor; D028084:Clusiaceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008958:Models, Molecular; D018515:Plant Leaves / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D014315:Triterpenes; C534175:friedoolean-28-oic acid