title: Fatigue: an overview.
abstract: Fatigue, a common presenting symptom in primary care, negatively impacts work performance, family life, and social relationships. The differential diagnosis of fatigue includes lifestyle issues, physical conditions, mental disorders, and treatment side effects. Fatigue can be classified as secondary to other medical conditions, physiologic, or chronic. The history and physical examination should focus on identifying common secondary causes (e.g., medications, anemia, pregnancy) and life-threatening problems, such as cancer. Results of laboratory studies affect management in only 5 percent of patients, and if initial results are normal, repeat testing is generally not indicated. Treatment of all types of fatigue should include a structured plan for regular physical activity that consists of stretching and aerobic exercise, such as walking. Caffeine and modafinil may be useful for episodic situations requiring alertness. Short naps are proven performance enhancers. Selective serotonin reuptake inhibitors, such as fluoxetine, paroxetine, or sertraline, may improve energy in patients with depression. Patients with chronic fatigue may respond to cognitive behavior therapy. Scheduling regular follow-up visits, rather than sporadic urgent appointments, is recommended for effective long-term management.
authors.affiliation: Department of Family Medicine, University at Buffalo, Buffalo, New York 14215, USA. trosenth@buffalo.edu
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Rosenthal
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Majeroni
authors.forename: Richard
authors.initials: R
authors.lastname: Pretorius
authors.forename: Khalid
authors.initials: K
authors.lastname: Malik
mesh_terms: D001521:Behavior Therapy; D001559:Benzhydryl Compounds / Q000627:therapeutic use; D002110:Caffeine / Q000627:therapeutic use; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D002908:Chronic Disease; D005221:Fatigue / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D000077408:Modafinil; D011320:Primary Health Care / Q000379:methods*; D012890:Sleep; D011795:Surveys and Questionnaires
chemical_list: D001559:Benzhydryl Compounds; D000697:Central Nervous System Stimulants; D002110:Caffeine; D000077408:Modafinil