title: Breast carcinoma metastatic to the orbit: an unusually late presentation.
abstract: An 83-year-old woman, diagnosed with breast carcinoma 28 years earlier, presented with left hyperglobus and limitation of extraocular motility. CT and MRI showed bilateral nodular thickening of extraocular muscles. Left orbital biopsy disclosed metastatic breast carcinoma. Subsequent positron-emission tomography/CT revealed diffuse metastatic disease. To the authors' knowledge, this case represents the longest reported interval from the diagnosis of primary breast cancer to the presentation of orbital metastasis.
authors.affiliation: Institute of Ophthalmology and Visual Science, New Jersey Medical School, Newark, New Jersey 07103, USA.
authors.forename: Tatyana
authors.initials: T
authors.lastname: Milman
authors.forename: Lillian
authors.initials: L
authors.lastname: Pliner
authors.forename: Paul D
authors.initials: PD
authors.lastname: Langer
mesh_terms: D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D002277:Carcinoma / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D000077289:Letrozole; D008279:Magnetic Resonance Imaging; D015409:Mastectomy, Radical / Q000379:methods; D009570:Nitriles / Q000627:therapeutic use; D009918:Orbital Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary*; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed; D014230:Triazoles / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D009570:Nitriles; D014230:Triazoles; D000077289:Letrozole