Pathomorphology of myocardial circulation: comparative study in increased left or right ventricle afterload.
Comparative study of pathomorphology of myocardial circulation under conditions of increased afterload of the left or right ventricles showed similar changes. All compartments of the coronary bed were plethoric, capillary blood stasis and perivascular edema, more pronounced in arterial vessels, were detected in both cases. These changes equally involved both ventricles and the ventricular septum. Significant differences consisted in local increase in the density of functioning capillaries. The increase was the maximum in hemodynamically overloaded ventricle and ventricular septum, presumably due to increase of their contractile activity. The density of functioning capillaries in the intact (vs. pressure overloaded) ventricle also increased, but to a lesser degree, which could be due to systemic neurohumoral effects. If increased afterload was complicated by the development of heart failure, circulatory disorders in the myocardium progressed. Significant increase in the density of functioning capillaries in all cardiac compartments indicated decreased vascular tone and exhaustion of coronary reserve. This was paralleled by a sharp arterial plethora in case of increased afterload of the left ventricle and sharp blood stasis in the microcirculatory bed in case of increased right ventricle afterload. Reduction of effective perfusion pressure in the presence of coronary dystonia can cause coronary insufficiency and myocardial ischemia in case of increased right ventricle afterload.
Tverskaya
M S
MS
Russian State Medical University, Federal Agency for Health Care and Social Development, Moscow. mtver@rsmu.ru
Sukhoparova
V V
VV
Karpova
V V
VV
Raksha
A P
AP
Kadyrova
M K
MK
Abdulkerimova
N Z
NZ
Bobrova
N A
NA
D000818:Animals; D001024:Aortic Valve Stenosis / Q000473:pathology; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000473:pathology / Q000503:physiopathology; D006168:Guinea Pigs; D006352:Heart Ventricles / Q000473:pathology*; D011666:Pulmonary Valve Stenosis / Q000473:pathology; D016277:Ventricular Function, Left / Q000502:physiology*; D016278:Ventricular Function, Right / Q000502:physiology*