title: Transmission of atypical bovine prions to mice transgenic for human prion protein.
abstract: To assess risk for cattle-to-human transmission of prions that cause uncommon forms of bovine spongiform encephalopathy (BSE), we inoculated mice expressing human PrP Met129 with field isolates. Unlike classical BSE agent, L-type prions appeared to propagate in these mice with no obvious transmission barrier. H-type prions failed to infect the mice.
authors.affiliation: Institut National de la Recherche Agronomique, Jouy-en-Josas, France. vincent.beringue@jouy.inra.fr
authors.forename: Vincent
authors.initials: V
authors.lastname: Béringue
authors.forename: Laëtitia
authors.initials: L
authors.lastname: Herzog
authors.forename: Fabienne
authors.initials: F
authors.lastname: Reine
authors.forename: Annick
authors.initials: A
authors.lastname: Le Dur
authors.forename: Cristina
authors.initials: C
authors.lastname: Casalone
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Vilotte
authors.forename: Hubert
authors.initials: H
authors.lastname: Laude
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D002417:Cattle; D016643:Encephalopathy, Bovine Spongiform / Q000635:transmission*; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D018620:PrPSc Proteins / Q000378:metabolism; D011328:Prions / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D019076:Transgenes
chemical_list: D018620:PrPSc Proteins; D011328:Prions