title: Interest of BIS monitoring to guide propofol infusion during the anhepatic phase of orthotopic liver transplantation.
abstract: OBJECTIVE
  The anhepatic phase of orthotopic liver transplantation (OLT) is associated with significant changes in pharmacokinetics. The aim of this study was to compare the influence of this phase on propofol target concentrations during BIS guided target controlled infusion (TCI).
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Eight patients aged 25 to 65 years, Child-Pugh status A-B scheduled for OLT were prospectively included. Anesthesia was performed using TCI of propofol (Diprifusor, Marsh pharmacokinetic model), sufentanil and cisatracurium. Propofol target concentration was adjusted to maintain BIS values between 40 and 50.
  
  
  RESULTS
  To maintain stable BIS values, propofol target concentrations should be decreased during the anhepatic phase versus the dissection one (2.0 microg/ml+/-0.8 versus 3.0 microg/ml+/-0.9, p<0.0001).
  
  
  CONCLUSIONS
  BIS could be useful to titrate propofol infusion during the anhepatic phase of OLT.
authors.affiliation: Department of Anesthesia and Critical Care Service, Beaujon University Hospital, 100, boulevard du Général-Leclerc, 92100 Clichy, France.
authors.forename: L
authors.initials: L
authors.lastname: Tremelot
authors.forename: A
authors.initials: A
authors.lastname: Restoux
authors.forename: C
authors.initials: C
authors.lastname: Paugam-Burtz
authors.forename: S
authors.initials: S
authors.lastname: Dahmani
authors.forename: L
authors.initials: L
authors.lastname: Massias
authors.forename: C
authors.initials: C
authors.lastname: Peuch
authors.forename: J
authors.initials: J
authors.lastname: Belghiti
authors.forename: J
authors.initials: J
authors.lastname: Mantz
mesh_terms: D000328:Adult; D000368:Aged; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous / Q000379:methods; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods*; D015742:Propofol / Q000008:administration & dosage*; D011446:Prospective Studies
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol