A two-step pathway to resist fasting.
All vertebrate animals have developed a sophisticated regulatory system to cope with frequent and unpredictable episodes of fasting. A recent letter to Nature suggests that a switch from early gluconeogenic gene activation via CRTC2 (also known as TORC2) to late action of FOXO1 is critical to this process.
Kaestner
Klaus H
KH
Institute for Diabetes, Obesity and Metabolism, Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. kaestner@mail.med.upenn.edu
D002467:Cell Nucleus / Q000378:metabolism; D005215:Fasting; D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000378:metabolism; D005943:Gluconeogenesis / Q000235:genetics*; D034622:RNA Interference; D056564:Sirtuin 1; D037761:Sirtuins / Q000235:genetics / Q000378:metabolism; D013997:Time Factors; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D050880:p300-CBP Transcription Factors / Q000235:genetics / Q000378:metabolism
C493245:CRTC2 protein, human; C085126:FOXO1 protein, human; D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors; D014157:Transcription Factors; D050880:p300-CBP Transcription Factors; C447939:SIRT1 protein, human; D056564:Sirtuin 1; D037761:Sirtuins