title: The effect of Ecstasy on memory is moderated by a functional polymorphism in the cathechol-O-methyltransferase (COMT) gene.
abstract: There is ample evidence for decreased verbal memory in heavy Ecstasy users. However, findings on the presence of a dose-response relation are inconsistent, possibly due to individual differences in genetic vulnerability. Catechol-O-methyltransferase (COMT) is involved in the catabolism of Ecstasy. Therefore, COMT gene polymorphisms may moderate this vulnerability. We prospectively assessed verbal memory in subjects with a high risk for future Ecstasy use, and compared 59 subjects after first Ecstasy use with 60 subjects that remained Ecstasy-naive. In addition, we tested the interaction effect of Ecstasy and the functional val (158)met polymorphism on verbal memory. Met-allele carriers were somewhat more sensitive to the effects of Ecstasy on verbal learning than homozygous val-subjects. After correction for the use of other substances this effect was no longer statistically significant. The findings suggest that the COMT gene moderates the negative effect of Ecstasy on memory, but also other drug use seems to play a role.
authors.affiliation: Amsterdam Institute for Addiction Research, Department of Psychiatry, Academic Medical Center of the University of Amsterdam, 1070 AW Amsterdam, The Netherlands. t.schilt@amc.uva.nl
authors.forename: Thelma
authors.initials: T
authors.lastname: Schilt
authors.forename: Maarten W J
authors.initials: MW
authors.lastname: Koeter
authors.forename: Maartje M L
authors.initials: MM
authors.lastname: de Win
authors.forename: Janneke R
authors.initials: JR
authors.lastname: Zinkstok
authors.forename: Thérèse A
authors.initials: TA
authors.lastname: van Amelsvoort
authors.forename: Ben
authors.initials: B
authors.lastname: Schmand
authors.forename: Wim van
authors.initials: Wv
authors.lastname: den Brink
mesh_terms: D000293:Adolescent; D000328:Adult; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006801:Humans; D007361:Intelligence Tests; D008297:Male; D008568:Memory / Q000187:drug effects*; D011939:Mental Recall / Q000187:drug effects; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000494:pharmacology*; D009483:Neuropsychological Tests; D011110:Polymorphism, Genetic / Q000235:genetics*; D018490:Serotonin Agents / Q000494:pharmacology*; D012959:Socioeconomic Factors; D019966:Substance-Related Disorders / Q000523:psychology; D014706:Verbal Learning / Q000187:drug effects; D055815:Young Adult
chemical_list: D018490:Serotonin Agents; D002394:Catechol O-Methyltransferase; D018817:N-Methyl-3,4-methylenedioxyamphetamine