title: Fagraldehyde, a secoiridoid isolated from Fagraea fragrans.
abstract: A secoiridoid aglycone with an atypical skeleton, named fagraldehyde (1), together with several known secoiridoids (gentiopicroside (2), sweroside (3), and swertiamarin (4)) were isolated from the bark and leaves of Fagraea fragrans collected in Cambodia. The conformations of 1 were evaluated on the basis of molecular modeling and NOESY correlations. A hypothetical biogenesis of fagraldehyde was proposed to explain the unusual skeleton. Compound 1 was weakly active in vitro against Plasmodium falciparum.
authors.affiliation: Laboratoire de Pharmacognosie, Drug Research Center (CIRM), Université de Liège, CHU-B36, 1 AVenue de l'Hôpital, B-4000 Liège, Belgium. MC.Jonville@ulg.ac.be
authors.forename: Marie-Caroline
authors.initials: MC
authors.lastname: Jonville
authors.forename: Marie
authors.initials: M
authors.lastname: Capel
authors.forename: Michel
authors.initials: M
authors.lastname: Frédérich
authors.forename: Luc
authors.initials: L
authors.lastname: Angenot
authors.forename: Georges
authors.initials: G
authors.lastname: Dive
authors.forename: Robert
authors.initials: R
authors.lastname: Faure
authors.forename: Nadine
authors.initials: N
authors.lastname: Azas
authors.forename: Evelyne
authors.initials: E
authors.lastname: Ollivier
mesh_terms: D000818:Animals; D002160:Cambodia; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification; D057888:Iridoid Glucosides; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D024301:Plant Bark / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal; D010963:Plasmodium falciparum / Q000187:drug effects*; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D005960:Glucosides; D057888:Iridoid Glucosides; D039823:Iridoids; D011753:Pyrones; C534646:fagraldehyde; C012997:gentiopicroside; C013270:swertiamarin; D007770:L-Lactate Dehydrogenase; C049412:sweroside