A TRP channel-steroid marriage.
A surprising functional association between TRPM3, a mysterious member of the family of transient receptor potential (TRP) cation channels, and the sulphated version of pregnenolone, 'mother' of all steroid hormones, has been identified.
Nilius
Bernd
B
Department of Molecular Cell Biology, Laboratory of Ion Channel Research, KU Leuven, Campus Gasthuisberg, Herestraat 49, bus 802, B-3000 Leuven, Belgium. bernd.nilius@med.kuleuven.be
Voets
Thomas
T
D000818:Animals; D006801:Humans; D050417:Insulin-Secreting Cells / Q000187:drug effects / Q000378:metabolism; D015640:Ion Channel Gating / Q000187:drug effects; D051379:Mice; D011284:Pregnenolone / Q000494:pharmacology; D051381:Rats; D011987:Receptors, Steroid / Q000378:metabolism*; D050053:TRPM Cation Channels / Q000378:metabolism*
D011987:Receptors, Steroid; D050053:TRPM Cation Channels; C018370:pregnenolone sulfate; D011284:Pregnenolone