Efficient mono- and bis-functionalization of 3,6-dichloropyridazine using (tmp)2Zn.2MgCl2.2LiCl.
3,6-Dichloropyridazine undergoes a smooth metallation using (tmp)2Zn.2MgCl2.2LiCl. The resulting bis-organozinc species react with various electrophiles; subsequent functionalization via a second metallation proceeds readily; further reactions with hydrazine lead to highly substituted pyrazolo[3,4-c]pyridazines derivatives.
Wunderlich
Stefan
S
Department Chemie, Ludwig-Maximilians-Universität München, Butenandstr. 5-13, Haus F, 81377, München, Germany.
Knochel
Paul
P