Genome-wide linkage scan for prostate cancer susceptibility from the University of Michigan Prostate Cancer Genetics Project: suggestive evidence for linkage at 16q23.
BACKGROUND
Prostate cancer linkage studies have been used to localize rare and presumably highly penetrant cancer susceptibility genes. Underlying genetic heterogeneity, as well as the high sporadic background of the disease, has resulted in many signals that are often not reproducible between research studies.


METHODS
We conducted a SNP-based genome wide linkage scan on 131 Caucasian prostate cancer families participating in the University of Michigan Prostate Cancer Genetics Project (PCGP).


RESULTS
The strongest evidence for linkage was detected at 16q23 (LOD = 2.70 at rs1079635). Prostate cancer linkage to the same region of 16q23 has been observed by others and the region contains several strong candidate genes including the known prostate cancer tumor suppressor genes ATBF1 and WWOX. This linkage signal was not detected in our prior linkage study on 175 PCGP families, illustrating the genetic heterogeneity underlying prostate cancer susceptibility.


CONCLUSIONS
Further linkage studies in combination with tumor analyses from linked families are in progress to identify the putative hereditary prostate cancer gene at 16q23.
Lange
Ethan M
EM
Department of Genetics, University of North Carolina, Chapel Hill, USA.
Beebe-Dimmer
Jennifer L
JL
Ray
Anna M
AM
Zuhlke
Kimberly A
KA
Ellis
Jaclyn
J
Wang
Yunfei
Y
Walters
Sarah
S
Cooney
Kathleen A
KA
D000368:Aged; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics*; D008040:Genetic Linkage / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D010088:Oxidoreductases / Q000235:genetics; D011471:Prostatic Neoplasms / Q000235:genetics*; D025521:Tumor Suppressor Proteins / Q000235:genetics; D000074584:WW Domain-Containing Oxidoreductase
D018398:Homeodomain Proteins; D025521:Tumor Suppressor Proteins; C071660:ZFHX3 protein, human; D010088:Oxidoreductases; D000074584:WW Domain-Containing Oxidoreductase; C486071:WWOX protein, human