Blood plasma proteins modulate the broncholytic effects of a muscarinic receptor antagonist.
Blood plasma proteins modulated the effects of muscarinic receptor antagonist methacin. Administration of methacin in combination with albumin or C-reactive protein (but not with IgG) abolished the broncholytic effect of methacin. It was probably associated with allosteric antagonism to M2, cholinergic receptors on non-nervous cells, which increased antibody production and mediator response. The concentration of serotonin in mesenteric lymph nodes was high during shock.
Nezhinskaya
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S. V. Anichkov Department of Neuropharmacology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg. sns@iem.spb.ru
Vladykin
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Sapronov
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D000418:Albumins / Q000378:metabolism; D000707:Anaphylaxis / Q000276:immunology; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism; D006168:Guinea Pigs; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000378:metabolism; D008297:Male; D018727:Muscarinic Antagonists / Q000008:administration & dosage / Q000378:metabolism*; D010115:Oxyphenonium / Q000008:administration & dosage / Q000378:metabolism*; D011976:Receptors, Muscarinic / Q000378:metabolism*
D000418:Albumins; D001798:Blood Proteins; D007074:Immunoglobulin G; D018727:Muscarinic Antagonists; D011976:Receptors, Muscarinic; D002097:C-Reactive Protein; D010115:Oxyphenonium