title: Putting the Diabetes Prevention Program into practice: a program for weight loss and cardiovascular risk reduction for patients with metabolic syndrome or type 2 diabetes mellitus.
abstract: BACKGROUND
  The increasing incidence and prevalence of metabolic syndrome and type 2 diabetes mellitus (DM) have significant implications on health world-wide. Large clinical trials have demonstrated the effectiveness of a comprehensive lifestyle program with a goal of moderate weight loss (5-7%) and regular exercise (150 minutes/week), resulting in a significant decrease in the incidence of type 2 DM and cardiovascular risk.
  
  
  METHODS
  This study reports on the translation of the multi-center Diabetes Prevention Program (DPP) into a cardiac rehabilitation program, utilizing the expertise and experience of a cardiac rehabilitation program staff. The study adapted materials from the DPP to develop a program that fit local needs for diabetes prevention.
  
  
  RESULTS
  Most participants completed the program (11 months) and their moderate weight loss was maintained for 11-12 months. At 11-12 months, waist circumference was reduced by approximately 2 inches, percent body fat was reduced by 5% (11% relative decrease, p<.05), weight was decreased by 10.1 pounds (p<.05), and blood pressure was reduced 8/3 mm Hg (p<.05). Exercise, nutrition, glucose, triglycerides, LDL-cholesterol and HDL cholesterol were all were significantly improved at 11-12 months (p<.05).
  
  
  CONCLUSIONS
  Efforts to improve lifestyle and reduce body weight are important to patients at risk of developing diabetes. This program demonstrates that an intensive effort can significantly improve lifestyle and reduce body weight in patients with DM or at risk for DM. A program that simulates cardiac rehabilitation, translated from a successful clinical trial into practice, resulted in significant reduction and improvement in metabolic outcomes and cardiovascular risk. Support for cardiac rehabilitation from insurers to develop similar programs is encouraged and deserves further study.
authors.affiliation: University of Wisconsin School of Medicine and Public Health, Department of Medicine, and Medicine and Family Medicine, University of Wisconsin Hospital and Clinics, H6/349 Clinical Sciences Center, 600 Highland Avenue, Madison, WI 53792, USA. pem@medicine.wisc.edu
authors.forename: P E
authors.initials: PE
authors.lastname: McBride
authors.forename: J A
authors.initials: JA
authors.lastname: Einerson
authors.forename: H
authors.initials: H
authors.lastname: Grant
authors.forename: C
authors.initials: C
authors.lastname: Sargent
authors.forename: G
authors.initials: G
authors.lastname: Underbakke
authors.forename: M
authors.initials: M
authors.lastname: Vitcenda
authors.forename: L
authors.initials: L
authors.lastname: Zeller
authors.forename: J H
authors.initials: JH
authors.lastname: Stein
mesh_terms: D000273:Adipose Tissue; D000328:Adult; D001786:Blood Glucose; D001794:Blood Pressure; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000628:therapy*; D015444:Exercise; D005260:Female; D006293:Health Promotion; D006331:Heart Diseases / Q000534:rehabilitation; D006801:Humans; D008019:Life Style; D008297:Male; D024821:Metabolic Syndrome / Q000628:therapy*; D008875:Middle Aged; D009752:Nutritional Status; D009765:Obesity / Q000628:therapy*; D012307:Risk Factors; D055105:Waist Circumference; D015431:Weight Loss
chemical_list: D001786:Blood Glucose; D002784:Cholesterol