Experimental and clinical study of the effect of artrofoon on proinflammatory cytokine production.
The effect of Artrofoon on the production of proinflammatory cytokines was evaluated in experiments on mice with collagen-induced arthritis and in a clinical study on patients with rheumatoid arthritis. Artrofoon produced an antiinflammatory effect on animals with collagen-induced arthritis and reduced clinical signs of inflammation in patients with rheumatoid arthritis. These changes were accompanied by a significant decrease in the production of tumor necrosis factor-alpha and interleukin-1beta.
Kachanova
M V
MV
Materia Medica Holding Research-and-Production Company, Moscow. kachanovamv@materiamedica.ru
Sherstoboyev
E Y
EY
Babayeva
A R
AR
Tcherevkova
E V
EV
Dugina
J L
JL
Kislitsyna
O S
OS
Epstein
O I
OI
Sergeeva
S A
SA
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use; D001169:Arthritis, Experimental / Q000188:drug therapy / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000276:immunology; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D053583:Interleukin-1beta / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
D000911:Antibodies, Monoclonal; C503436:Artrofoon; D016207:Cytokines; D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha