title: Intrathoracic organ transplantation from donors with meningitis: a single-center 20-year experience.
abstract: BACKGROUND
  Availability of cadaveric organs continues to be the key factor limiting the number of transplants performed. Donor with bacterial meningitis is often considered to be controversial for organ retrieval. The purpose of this retrospective study was to review the long-term outcome of orthotopic heart and lung transplantation at our institution, from donors who died as a result of meningitis.
  
  
  METHODS
  Between July 1986 and July 2006, 39 adult patients who underwent heart and lung transplantation performed with organs from cadaveric donors with bacterial meningitis were retrospectively studied. Donors and recipients were identified by a prospectively kept database. Bacterial meningitis was identified either with positive blood or cerebrospinal fluid culture and positive signs and symptoms. All patients had one or more of these criteria. There were 15 heart, 12 lung (4 bilateral), and 12 heart-lung transplants.
  
  
  RESULTS
  All donors had identified pathogens: Neisseria meningitidis (n = 21; 53.8%), Streptococcus pneumoniae (n = 16; 41%), and Haemophilus influenzae (n = 2; 5.2%). Adequate antimicrobial therapy before organ retrieval and after transplant was administered. The hospital mortality was 10.2% (n = 4). There were no infectious complications caused by meningeal pathogens. Other causes of hospital mortality were rejection (n = 2), intracranial bleeding (n = 1), and staphylococcus sepsis (n = 1). The mean posttransplant follow-up was 5.35 +/- 5.54 years (range, 1 month to 18.9 years).
  
  
  CONCLUSIONS
  Intrathoracic organ transplantation using donors with bacterial meningitis is an acceptable strategy. No organism (Neisseria meningitides, Streptococcus pneumoniae, and Haemophilus influenzae) could be identified as contraindication because no recipient died of infectious-related diseases.
authors.affiliation: Department of Cardiac Surgery, Harefield Hospital, Royal Brompton and Harefield Hospitals NHS Trust, London, United Kingdom. t.bahrami2@rbht.nhs.uk
authors.forename: Toufan
authors.initials: T
authors.lastname: Bahrami
authors.forename: Hunaid A
authors.initials: HA
authors.lastname: Vohra
authors.forename: Kasra
authors.initials: K
authors.lastname: Shaikhrezai
authors.forename: Samad
authors.initials: S
authors.lastname: Tadjkarimi
authors.forename: Nick
authors.initials: N
authors.lastname: Banner
authors.forename: Mohammed
authors.initials: M
authors.lastname: Amrani
authors.forename: Magdi
authors.initials: M
authors.lastname: Yacoub
authors.forename: Asghar
authors.initials: A
authors.lastname: Khaghani
mesh_terms: D000328:Adult; D002102:Cadaver; D002648:Child; D000075202:Contraindications; D005260:Female; D005500:Follow-Up Studies; D016041:Heart-Lung Transplantation / Q000401:mortality* / Q000706:statistics & numerical data; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D016920:Meningitis, Bacterial / Q000453:epidemiology* / Q000382:microbiology; D012189:Retrospective Studies; D015996:Survival Rate; D014019:Tissue Donors / Q000706:statistics & numerical data*; D020858:Tissue and Organ Harvesting; D009927:Tissue and Organ Procurement / Q000706:statistics & numerical data*