title: [Molecular epidemiological study on oxidative DNA damage among Hasake ethnic migrants in Shenzhen].
abstract: OBJECTIVE
  To explore the relationship of migration and oxidative DNA damage by comparative study of oxidative DNA damage effects on people with different years of migration among Xinjiang Hasake ethnicity in Shenzhen.
  
  
  METHODS
  Sixty Hasake residents in Shenzhen were selected, and were divided into three groups (n=20) according to the years of migration. Major changes of their life style were investigated. 8-hydroxy-2'-deoxyguanosine (8-OH-dG) levels in urine were analyzed, and comet assay of peripheral blood lymphocytes conducted.
  
  
  RESULTS
  When comparing with the group having a shorter than 1 year of stay,a significant decrease of oliveira tail moment and tail/head length in comet assay in the >3 years group (P < 0.05) was observed 8-OH-dG level decreased significantly in 1-3 years group (P < 0.05) and >3 years group (P < 0.01).
  
  
  CONCLUSIONS
  Our results suggested that life style changes which related to migration might reduce DNA damage in Hasake nationalities.
authors.affiliation: Department of Genetic Toxicology, Shenzhen Center for Disease Control and Prevention, Shenzhen 518020, China.
authors.forename: Yue-bin
authors.initials: YB
authors.lastname: Ke
authors.forename: Jin-quan
authors.initials: JQ
authors.lastname: Cheng
authors.forename: Zhi-hong
authors.initials: ZH
authors.lastname: Shuai
authors.forename: Ren-li
authors.initials: RL
authors.lastname: Zhang
authors.forename: Gao-feng
authors.initials: GF
authors.lastname: Jiang
authors.forename: Chun-rong
authors.initials: CR
authors.lastname: Tan
authors.forename: Zun-zhen
authors.initials: ZZ
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D002681:China / Q000453:epidemiology; D020552:Comet Assay; D004249:DNA Damage; D004260:DNA Repair; D003849:Deoxyguanosine / Q000652:urine*; D006184:Habits; D006801:Humans; D008297:Male; D017720:Molecular Epidemiology; D018384:Oxidative Stress; D012907:Smoking / Q000453:epidemiology / Q000208:ethnology; D014171:Transients and Migrants; D055815:Young Adult
chemical_list: D003849:Deoxyguanosine