title: Genome-wide association scan for stature in Chinese: evidence for ethnic specific loci.
abstract: In Caucasian, several studies have identified some common variants associated with human stature variation. However, no such study was performed in Chinese, which is the largest population in the world and evidently differs from Caucasian in genetic background. To identify common or ethnic specific genes for stature in Chinese, an initial GWAS and follow-up replication study were performed. Our initial GWAS study found that a group of 13 contiguous SNPs, which span a region of approximately 150 kb containing two neighboring genes, zinc finger protein (ZNP) 510 and ZNP782, achieved strong signals for association with stature, with P values ranging from 9.71 x 10(-5) to 3.11 x 10(-6). After false discovery rate correction for multiple testing, 9 of the 13 SNPs remain significant (FDR q=0.036-0.046). The follow-up replication study in an independent 2,953 unrelated southern Chinese confirmed the association of rs10816533 with stature (P=0.029). All the 13 SNPs were in consistently strong linkage disequilibrium (D'>0.99) and formed a single perfect haplotype block. The minor allele frequencies for the 13 contiguous SNPs have evidently ethnic difference, which range from 0.21 to 0.33 in Chinese but have as low as approximately 0.017 reported in dbSNP database in Caucasian. The present results suggest that the genomic region containing the ZNP510 and ZNP782 genes is an ethnic specific locus associated with stature variation in Chinese.
authors.affiliation: Laboratory of Molecular and Statistical Genetics and Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, 410081 Changsha, Hunan, People's Republic of China.
authors.forename: Shu-Feng
authors.initials: SF
authors.lastname: Lei
authors.forename: Tie-Lin
authors.initials: TL
authors.lastname: Yang
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Tan
authors.forename: Xiang-Ding
authors.initials: XD
authors.lastname: Chen
authors.forename: Yan
authors.initials: Y
authors.lastname: Guo
authors.forename: Yan-Fang
authors.initials: YF
authors.lastname: Guo
authors.forename: Liang
authors.initials: L
authors.lastname: Zhang
authors.forename: Xiao-Gang
authors.initials: XG
authors.lastname: Liu
authors.forename: Han
authors.initials: H
authors.lastname: Yan
authors.forename: Feng
authors.initials: F
authors.lastname: Pan
authors.forename: Zhi-Xin
authors.initials: ZX
authors.lastname: Zhang
authors.forename: Yu-Mei
authors.initials: YM
authors.lastname: Peng
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhou
authors.forename: Li-Na
authors.initials: LN
authors.lastname: He
authors.forename: Xue-Zhen
authors.initials: XZ
authors.lastname: Zhu
authors.forename: Jing
authors.initials: J
authors.lastname: Cheng
authors.forename: Yao-Zhong
authors.initials: YZ
authors.lastname: Liu
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Papasian
authors.forename: Hong-Wen
authors.initials: HW
authors.lastname: Deng
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D001827:Body Height / Q000235:genetics*; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D044465:White People / Q000235:genetics; D055815:Young Adult