Panton-Valentine leukocidin is expressed at toxic levels in human skin abscesses.
Pus samples were prospectively collected from patients with Staphylococcus aureus skin infections and tested for Panton-Valentine leukocidin (PVL). PVL was detected at concentrations that were toxic for rabbit skin in all specimens from patients infected with strains harbouring PVL genes.
Badiou
C
C
INSERM U851, Université de Lyon, Centre National de référence des Staphylocoques, Faculté Laennec, Lyon, France.
Dumitrescu
O
O
Croze
M
M
Gillet
Y
Y
Dohin
B
B
Slayman
D H
DH
Allaouchiche
B
B
Etienne
J
J
Vandenesch
F
F
Lina
G
G
D000038:Abscess / Q000382:microbiology* / Q000473:pathology*; D001427:Bacterial Toxins / Q000032:analysis*; D005098:Exotoxins / Q000032:analysis*; D006801:Humans; D007956:Leukocidins / Q000032:analysis*; D013207:Staphylococcal Skin Infections / Q000473:pathology*; D013211:Staphylococcus aureus / Q000302:isolation & purification*; D013492:Suppuration / Q000382:microbiology
D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin