Peripheral eosinophil count and allergy in patients with coronary artery disease.
OBJECTIVE
to investigate the relationship between peripheral blood eosinophil count and history of allergy with CAD.


METHODS
in a case-control study in Ali-ebn-Abitaleb Educational Hospital of Rafsanjan, Iran, 190 individuals(95 with CAD and 95 without CAD) with mean age of 59.4 +/- 12.6 were investigated. Eosinophil count in peripheral blood, eosinophil leukocyte ratio, neutrophil count and neutrophil/leukocyte ratio were measured. A history of allergy was taken from the participants.


RESULTS
there were no significant differences in sex and age among two groups. The mean leukocyte count was 8802.6 +/- 253.3 and 3813.7 +/- 351.9 for case and control groups,respectively; that is, a statistically significant difference,(p<0.05). Eosinophil percent was 1.43% and 0.88% in case and control groups, respectively and this parameter was also significantly higher in case group. History of allergy was not different between the 2 groups. Elevated numbers of eosinophils were observed in Iranian patients with CAD.


CONCLUSIONS
the present results support the theory that eosinophils may have a role in the pathogenesis of ischemic heart disease.
Nadimi
Ali Esmaeili
AE
Department of Internal Medicine, Medical school, RafsanjanUniversity of Medical Sciences and Health Services,Tehran, Iran. swt_f@yahoo.com
Ahmadi
Jafar
J
Mehrabian
Mehrnoush
M
D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D004804:Eosinophils; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology / Q000276:immunology*; D007249:Inflammation / Q000276:immunology / Q000503:physiopathology; D007492:Iran / Q000453:epidemiology; D007958:Leukocyte Count; D007962:Leukocytes; D008297:Male; D008875:Middle Aged; D012307:Risk Factors