title: Catalytic carbonyl addition through transfer hydrogenation: a departure from preformed organometallic reagents.
abstract: Classical protocols for carbonyl allylation, propargylation and vinylation typically rely upon the use of preformed allyl metal, allenyl metal and vinyl metal reagents, respectively, mandating stoichiometric generation of metallic byproducts. Through transfer hydrogenative C-C coupling, however, carbonyl addition may be achieved from the aldehyde or alcohol oxidation level in the absence of stoichiometric organometallic reagents or metallic reductants. Here, we review transfer hydrogenative methods for carbonyl addition, which encompass the first catalytic protocols enabling direct C-H functionalization of alcohols.
authors.affiliation: University of Texas at Austin, Department of Chemistry and Biochemistry, 1 University Station, A5300, Austin, TX 78712-1167, USA.
authors.forename: John F
authors.initials: JF
authors.lastname: Bower
authors.forename: In Su
authors.initials: IS
authors.lastname: Kim
authors.forename: Ryan L
authors.initials: RL
authors.lastname: Patman
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Krische
mesh_terms: D000480:Alkynes / Q000737:chemistry; D002255:Carbonic Acid / Q000737:chemistry*; D002384:Catalysis; D006865:Hydrogenation; D007202:Indicators and Reagents; D009942:Organometallic Compounds / Q000737:chemistry*; D014753:Vinyl Compounds / Q000737:chemistry
chemical_list: D000480:Alkynes; D007202:Indicators and Reagents; D009942:Organometallic Compounds; D014753:Vinyl Compounds; D002255:Carbonic Acid