Synthesis of indene derivatives via electrophilic cyclization.
3-Iodo-1H-indene derivatives are synthesized by iodonium-promoted 5-endo-dig carbocyclization of 2-substituted ethynylmalonates. Various 2-substituted ethynylmalonates bearing aryl-, alkyl- and ether-protected propargyl alcohols were successfully converted to cyclized products. Their use in subsequent reactions as substrate and catalyst was investigated.
Khan
Zulfiqar Ali
ZA
School of Chemistry, Cardiff University, Park Place, Cardiff CF10 3AT, UK.
Wirth
Thomas
T
D003500:Cyclization; D007192:Indenes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D007192:Indenes