Overcoming obstacles in the search for the site of hematopoietic stem cell emergence.
The murine embryo has become a valuable tool to examine the ontogeny of hematopoiesis. However, the onset of the systemic circulation has long been a confounding developmental variable that may mask the site of blood cell emergence. This Minireview examines some approaches that have been applied to overcome this obstacle.
Yoshimoto
Momoko
M
Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Porayette
Prashanth
P
Yoder
Mervin C
MC
D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D015820:Cadherins / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology; D019070:Cell Lineage / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology; D042783:Endothelial Cells / Q000502:physiology; D006410:Hematopoiesis / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D051379:Mice; D018919:Neovascularization, Physiologic / Q000502:physiology*; D000099152:Cadherin 5
D015703:Antigens, CD; D015415:Biomarkers; D015820:Cadherins; D000099152:Cadherin 5