[Preparation and antibacterial activity of quaternary ammonium salt monomers].
OBJECTIVE
To prepare three quaternary ammonium salt (QAS) monomers, and to compare their antibacterial activities against four oral bacterial strains.


METHODS
Three antibacterial monomers [methacryloxyethyl benzyl dimethyl ammonium chloride (DMAE-BC), methacryloxyethyl m-chloro benzyl dimethyl ammonium chloride (DMAE-m-CBC), methacryloxyethyl cetyl dimethyl ammonium chloride (DMAE-CB)] were synthesized according to the general structure of target monomers. Their antibacterial effects were investigated using the broth dilution test on Gram-positive and Gram-negative bacterial strains (Streptococcus mutans, Streptococcus sanguis, Porphyromonas gingivalis, Prevotella melaninogenica ).


RESULTS
Three different monomers were successfully obtained. All the tested bacterial strains were susceptible to the three monomers, among which DMAE-CB exhibited the lowest minimal inhibitory concentrations (MIC) ranging from 1.2 to 4.8 mg/L.


CONCLUSIONS
All these three QAS monomers have different antibacterial activities against four oral bacteria strains. The data indicate that DMAE-CB may be a candidate antibacterial agent for oral infectious diseases.
Xiao
Yu-Hong
YH
Department of Prosthodontics, College of Stomatology, The Fourth Military Medical University, Xi'an, China.
Chen
Ji-Hua
JH
Fang
Ming
M
Xing
Xiao-Dong
XD
Li
Fang
F
Chai
Zhi-Guo
ZG
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D003764:Dental Materials / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D000644:Quaternary Ammonium Compounds / Q000737:chemistry / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D003764:Dental Materials; D000644:Quaternary Ammonium Compounds