title: Parallel synthesis of trisubstituted formamidines: a facile and versatile procedure.
abstract: A focused library of formamidines having several diversity points has been prepared. The use of isocyanate resin as scavenger may offer several practical advantages over conventional procedures, such as the ease of workup and availability. The technique described herein was performed in a parallel synthesis format. The whole protocol has potential use in high throughput synthesis for the preparation and purification of libraries of unsymmetrical formamidines containing sets of different aliphatic substituents.
authors.affiliation: Dipartimento di Chimica, Università degli Studi di Sassari, Sassari, Italy. anpo@uniss.it
authors.forename: Andrea
authors.initials: A
authors.lastname: Porcheddu
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Giacomelli
authors.forename: Ivana
authors.initials: I
authors.lastname: Piredda
mesh_terms: D000578:Amidines / Q000138:chemical synthesis*; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D017953:Isocyanates; D012117:Resins, Synthetic; D054852:Small Molecule Libraries / Q000138:chemical synthesis
chemical_list: D000578:Amidines; D017953:Isocyanates; D012117:Resins, Synthetic; D054852:Small Molecule Libraries; C077922:formamidine