[Impact of overweight on the outcome of ovarian stimulation].
Overweight and obesity have a negative impact on the efficacy of agents used to induce ovulation, and especially on the dose of clomiphene citrate or gonadotrophins required to achieve ovulation. BMI is a major predictor of the ovarian response. In IVF-ICSI cycles, overweight is associated with a decrease in the number of oocytes. While the pregnancy rate is not dependent on weight, the risk of early miscarriage is increased in obese women. Therefore, overweight should be managed before ovarian stimulation begins. The efficacy of insulin-sensitizing agents such as metformin is not fully clear, but their combination with clomiphene citrate or FSH seems promising.
Hugues
Jean-Noël
JN
Service de Médecine de la Reproduction, Hôpital Jean Verdier, Bondy 93 143.
D005260:Female; D006801:Humans; D050177:Overweight / Q000150:complications*; D010062:Ovulation Induction / Q000379:methods*; D027724:Reproductive Techniques, Assisted; D016896:Treatment Outcome