title: Polymorphisms of detoxification and DNA repair enzymes in myelodyplastic syndromes.
abstract: The genetic background may modify the individual's risk of developing cancer. We performed a case-control study to test the impact of genomic polymorphisms of 9 genes involved in xenobiotics detoxification and DNA repair in myelodysplastic syndromes (MDS). Frequencies of polymorphic variants of RAD51, XRCC3, NQO1, GSTA1, GSTM1, GSTT1, CYP3A4 and XPD enzymes were similar in patients and controls. On the other hand, the GSTP1-105Val allele was associated to an increased risk of MDS (O.R. 1.66; p=0.04) and to higher probability of overall survival in the low/intermediate-1 IPSS risk group (p=0.008). The GSTP1-Ile105Val polymorphism is likely to influence MDS risk and prognosis.
authors.affiliation: Istituto di Ematologia, Università Cattolica del Sacro Cuore, L go A Gemelli, Rome, Italy.
authors.forename: Emiliano
authors.initials: E
authors.lastname: Fabiani
authors.forename: Francesco
authors.initials: F
authors.lastname: D'Alò
authors.forename: Alessandra
authors.initials: A
authors.lastname: Scardocci
authors.forename: Mariangela
authors.initials: M
authors.lastname: Greco
authors.forename: Annalisa
authors.initials: A
authors.lastname: Di Ruscio
authors.forename: Marianna
authors.initials: M
authors.lastname: Criscuolo
authors.forename: Luana
authors.initials: L
authors.lastname: Fianchi
authors.forename: Livio
authors.initials: L
authors.lastname: Pagano
authors.forename: Stefan
authors.initials: S
authors.lastname: Hohaus
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Leone
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Voso
mesh_terms: D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D015331:Cohort Studies; D004260:DNA Repair / Q000235:genetics*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D009190:Myelodysplastic Syndromes / Q000235:genetics* / Q000401:mortality; D011110:Polymorphism, Genetic; D012307:Risk Factors; D015996:Survival Rate; D015262:Xenobiotics
chemical_list: D015262:Xenobiotics