[The clinical significance of autoantibodies against acetylcholine muscarinic 3 receptor in primary Sjögren's syndrome].
OBJECTIVE
To detect anti-M3 receptor antibodies in primary Sjögren's syndrome (pSS) patients and to explore its association with clinical manifestations.


METHODS
Anti-M3 antibodies were tested in 70 patients with pSS , 50 patients with systemic lupus erythematosus (SLE) and 76 normal controls with ELISA and Western blot. The correlation between anti-M3 antibodies and other clinical manifestations was analyzed.


RESULTS
(1) The positive rate of anti-M3 antibodies in pSS was 47.14% using ELISA and 60.00% using Western blot in SLE 4.00% using ELISA and 12.00% using Western blot and in normal controls 14.47% using ELISA and 15.79% using Western blot. (2) The incidence of schirmer test, tear break-up time (BUT), whole saliva flow rate, punctate epithelial erosions (PEE) on the corneas and external eye examination were not significantly different between the anti-M3 positive and negative groups. (3) The incidences of IgG, rheumatoid factor, SSB and fluorescence index (FI) > 3 were higher in the positive group than in the negative group using ELISA.


CONCLUSIONS
The positive rate of anti-M3 antibodies is higher in pSS than in SLE and normal controls and in some degree it has correlation with the lesion in salivary gland.
Wu
Ying
Y
Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
Li
Meng-Tao
MT
Zhao
Yan
Y
Feng
Sheng
S
Su
Li
L
Dong
Yi
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D000888:Antibodies, Anti-Idiotypic / Q000097:blood*; D001323:Autoantibodies / Q000097:blood*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D043587:Receptor, Muscarinic M3 / Q000276:immunology*; D011950:Receptors, Cholinergic / Q000276:immunology; D012859:Sjogren's Syndrome / Q000276:immunology* / Q000473:pathology
D000888:Antibodies, Anti-Idiotypic; D001323:Autoantibodies; D043587:Receptor, Muscarinic M3; D011950:Receptors, Cholinergic