title: Interest of ferulic acid ethyl ester in photoprotective creams: measure of efficacy by in vitro method.
abstract: Topical sunscreens have been used for many years on exposed areas to protect the skin from the damaging effects of ultraviolets. If the sunscreens were essential, it is suggested that they have adverse effects. We chose to study ferulic acid ethyl ester (FAEE) as agent which could potentially be used in sunscreen products. FAEE was incorporated at various concentrations into O/W emulsions. Total of 30 mg of product exactly weighed were spread on poly(methylmethacrylate) plates over the whole surface (25 cm(2)). So, sun protection factor (SPF) and PF-UVA of the creams were measured in vitro. Transmission measurements between 290 and 400 nm were carried out using a spectrophotometer equipped with an integrating sphere. Incorporated in O/W creams, at a concentration of 10%, FAEE give a SPF similar to that of benzymidazilate, a filter permitted in EU.
authors.affiliation: Faculty of Pharmacy, Universite de Nantes, Nantes Atlantique Universites, Nantes, France.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Choquenet
authors.forename: Celine
authors.initials: C
authors.lastname: Couteau
authors.forename: Eva
authors.initials: E
authors.lastname: Paparis
authors.forename: Laurence J M
authors.initials: LJ
authors.lastname: Coiffard
mesh_terms: D000465:Algorithms; D003373:Coumaric Acids / Q000494:pharmacology* / Q000627:therapeutic use; D004643:Emollients / Q000494:pharmacology; D010777:Photochemistry / Q000379:methods; D013472:Sunlight / Q000009:adverse effects; D013473:Sunscreening Agents / Q000494:pharmacology* / Q000627:therapeutic use; D014466:Ultraviolet Rays / Q000009:adverse effects
chemical_list: D003373:Coumaric Acids; D004643:Emollients; D013473:Sunscreening Agents; C004999:ferulic acid