title: In vitro release of fusidic acid and teicoplanin from cancellous bone allografts.
abstract: The characteristics of cancellous bone allografts as carriers of fusidic acid and teicoplanin are described. Particles of cancellous bone were compressed into a wiremesh cylinder; five replicas were impregnated for one hour into fusidic acid; and another five for one hour into teicoplanin. Elution was estimated daily. Concentrations of fusidic acid and teicoplanin were determined by a microbiological assay. Both antibiotics were eluted at very high concentrations within the first days. Allografts impregnated in fusidic acid provided concentrations above 20 microg/ml for 20 days. Eluted teicoplanin after day 4 was below 10 microg/ml. It is concluded that cancellous bone allografts may allow adequate in vitro elution of fusidic acid but not of teicoplanin. The latter results support their application in experimental models of osteomyelitis.
authors.affiliation: 4th Department of Internal Medicine, University of Athens, Greece.
authors.forename: K
authors.initials: K
authors.lastname: Kanellakopoulou
authors.forename: T
authors.initials: T
authors.lastname: Sahinides
authors.forename: T
authors.initials: T
authors.lastname: Tsaganos
authors.forename: N
authors.initials: N
authors.lastname: Galanakis
authors.forename: H
authors.initials: H
authors.lastname: Giamarellou
authors.forename: E J
authors.initials: EJ
authors.lastname: Giamarellos-Bourboulis
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001842:Bone and Bones; D004337:Drug Carriers; D005672:Fusidic Acid / Q000008:administration & dosage*; D006801:Humans; D066298:In Vitro Techniques; D017334:Teicoplanin / Q000008:administration & dosage*; D014184:Transplantation, Homologous
chemical_list: D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D005672:Fusidic Acid; D017334:Teicoplanin