Glucocorticoid receptor dynamics and gene regulation.
The glucocorticoid receptor regulates the expression of a large number of genes in mammalian cells. The interaction of this receptor with regulatory elements has been discovered to be highly dynamic, with occupancy states measured in seconds, rather than minutes or hours. This finding has led to a paradigm shift in our understanding of receptor function throughout the genome. The mechanisms involved in these rapid exchange events, as well as the implications for receptor function, are discussed.
Biddie
Simon C
SC
Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, MD 20892-5055, USA.
Hager
Gordon L
GL
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D042002:Chromatin Assembly and Disassembly / Q000502:physiology; D004268:DNA-Binding Proteins / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D051379:Mice; D008957:Models, Genetic; D018832:Molecular Chaperones / Q000502:physiology; D011401:Promoter Regions, Genetic / Q000502:physiology; D046988:Proteasome Endopeptidase Complex / Q000502:physiology; D011965:Receptors, Glucocorticoid / Q000235:genetics / Q000502:physiology*
D004268:DNA-Binding Proteins; C400564:MNBP-1 protein, human; D018832:Molecular Chaperones; D011965:Receptors, Glucocorticoid; D000255:Adenosine Triphosphate; D046988:Proteasome Endopeptidase Complex