title: Two new cytotoxic diterpenes from the rhizomes of Hedychium spicatum.
abstract: Phytochemical investigation of CHCl(3) extract of the rhizomes of Hedychium spicatum led to the isolation of two new labdane-type diterpenes, compounds 1 and 2 along with five known compounds (3-7). Their structures were established on the basis of NMR (1D and 2D) and mass spectroscopic analysis. In addition, all the isolates were tested for their cytotoxicity against the Colo-205 (Colo-cancer), A-431 (skin cancer), MCF-7 (breast cancer), A-549 (lung cancer) and Chinese hamster ovary cells (CHO). Two new compounds 1 and 2 were shown good cytotoxic activity.
authors.affiliation: Natural Products Laboratory, Indian Institute of Chemical Technology, Hyderabad, India.
authors.forename: P Prabhakar
authors.initials: PP
authors.lastname: Reddy
authors.forename: R Ranga
authors.initials: RR
authors.lastname: Rao
authors.forename: K
authors.initials: K
authors.lastname: Rekha
authors.forename: K
authors.initials: K
authors.lastname: Suresh Babu
authors.forename: J
authors.initials: J
authors.lastname: Shashidhar
authors.forename: G
authors.initials: G
authors.lastname: Shashikiran
authors.forename: V
authors.initials: V
authors.lastname: Vijaya Lakshmi
authors.forename: J Madhusudana
authors.initials: JM
authors.lastname: Rao
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification; D016466:CHO Cells; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D006801:Humans; D015394:Molecular Structure; D027343:Rhizome / Q000737:chemistry*; D030521:Zingiberaceae / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes