GABAB receptor agonist baclofen improves methamphetamine-induced cognitive deficit in mice.
In this study, we investigated the effects of GABA(A) and GABA(B) receptor agonists on the methamphetamine-induced impairment of recognition memory in mice. Repeated treatment with methamphetamine at a dose of 1 mg/kg for 7 days induced an impairment of recognition memory. Baclofen, a GABA(B) receptor agonist, ameliorated the repeated methamphetamine-induced cognitive impairment, although gaboxadol, a GABA(A) receptor agonist, had no significant effect. GABA(B) receptors may constitute a putative new target in treating cognitive deficits in patients suffering from schizophrenia, as well as methamphetamine psychosis.
Arai
Sawako
S
Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920-1192, Japan.
Takuma
Kazuhiro
K
Mizoguchi
Hiroyuki
H
Ibi
Daisuke
D
Nagai
Taku
T
Kamei
Hiroyuki
H
Kim
Hyoung-Chun
HC
Yamada
Kiyofumi
K
D000818:Animals; D001418:Baclofen / Q000494:pharmacology* / Q000627:therapeutic use; D003072:Cognition Disorders / Q000139:chemically induced* / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D018755:GABA Agonists / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008568:Memory / Q000187:drug effects*; D008694:Methamphetamine / Q000009:adverse effects; D051379:Mice; D008813:Mice, Inbred ICR; D012559:Schizophrenia / Q000188:drug therapy / Q000503:physiopathology; D013997:Time Factors
D018755:GABA Agonists; D008694:Methamphetamine; D001418:Baclofen