Diffuse optical tomography of the breast: initial validation in benign cysts.
OBJECTIVE
The purpose of this study was to validate a newly developed diffuse optical tomography (DOT) system on benign cysts in the breast.


METHODS
Eight patients with 20 benign cysts were included. Study procedures consisted of optical breast imaging and breast magnetic resonance imaging (MRI) for comparison. A reconstruction algorithm computed three-dimensional images for each of the four near-infrared wavelengths used by our DOT system (Philips Healthcare, Best, The Netherlands). These images were combined using a spectroscopic model to assess tissue composition and lesion size.


RESULTS
Twenty cysts were analyzed in eight patients. By using the spectroscopic information, 13 of 20 cysts (65%) were visualized with DOT, confirming their high water and low total hemoglobin content. Lesion size and location showed good agreement with MRI; Pearson correlation coefficient was 0.7 (p < 0.01).


CONCLUSIONS
DOT can visualize benign cysts in the breast and elucidate their high water and low total hemoglobin content by spectroscopic analysis.
van de Ven
Stephanie
S
Radiology, University Medical Center Utrecht, Utrecht, the Netherlands. s.m.w.y.vandeven-2@umcutrecht.nl
Elias
Sjoerd
S
Wiethoff
Andrea
A
van der Voort
Marjolein
M
Leproux
Anais
A
Nielsen
Tim
T
Brendel
Bernhard
B
Bakker
Leon
L
van der Mark
Martin
M
Mali
Willem
W
Luijten
Peter
P
D000328:Adult; D000465:Algorithms; D001940:Breast / Q000473:pathology*; D047688:Breast Cyst / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged; D015203:Reproducibility of Results; D013057:Spectrum Analysis; D041622:Tomography, Optical / Q000379:methods*
D006454:Hemoglobins