Widespread occurrence and lateral transfer of the cyanobactin biosynthesis gene cluster in cyanobacteria.
Cyanobactins are small cyclic peptides produced by cyanobacteria. Here we demonstrate the widespread but sporadic occurrence of the cyanobactin biosynthetic pathway. We detected a cyanobactin biosynthetic gene in 48 of the 132 strains included in this study. Our results suggest that cyanobactin biosynthetic genes have a complex evolutionary history in cyanobacteria punctuated by a series of ancient horizontal gene transfer events.
Leikoski
Niina
N
Department of Applied Chemistry and Microbiology, University of Helsinki, Viikki Biocenter, Helsinki, Finland.
Fewer
David P
DP
Sivonen
Kaarina
K
D000458:Cyanobacteria / Q000235:genetics* / Q000378:metabolism*; D019143:Evolution, Molecular; D022761:Gene Transfer, Horizontal; D005798:Genes, Bacterial; D053858:Metabolic Networks and Pathways / Q000235:genetics*; D005810:Multigene Family; D010456:Peptides, Cyclic / Q000096:biosynthesis*
D010456:Peptides, Cyclic