title: Left frontal lobe contributions to concept formation: a quantitative MRI study of performance on the Delis-Kaplan Executive Function System Sorting Test.
abstract: This study examined relationships between lobar volumes and performance on the Delis-Kaplan Executive Function System (D-KEFS) Sorting Test, a standardized measure of concept formation. There were 89 participants: 19 patients with probable Alzheimer's disease, 25 patients with frontotemporal dementia, 13 patients with semantic dementia, 12 patients with progressive nonfluent aphasia, 9 patients with probable progressive supranuclear palsy, 2 patients with possible progressive supranuclear palsy, and 9 healthy participants. We used BRAINS2 software to generate volumes of the right and left frontal, temporal, and parietal lobes. Multiple regression analysis indicated that, after controlling for Mini-Mental State Examination scores, intracranial volume, and demographic variables, only the left frontal lobe significantly predicted performance on the D-KEFS Sorting Test.
authors.affiliation: Psychology Service, Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA. efine@ucsd.com
authors.forename: Eric M
authors.initials: EM
authors.lastname: Fine
authors.forename: Dean C
authors.initials: DC
authors.lastname: Delis
authors.forename: David
authors.initials: D
authors.lastname: Dean
authors.forename: Victoria
authors.initials: V
authors.lastname: Beckman
authors.forename: Bruce L
authors.initials: BL
authors.lastname: Miller
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Rosen
authors.forename: Joel H
authors.initials: JH
authors.lastname: Kramer
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D003210:Concept Formation / Q000502:physiology*; D003704:Dementia / Q000145:classification / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005625:Frontal Lobe / Q000473:pathology / Q000503:physiopathology*; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D009483:Neuropsychological Tests; D011340:Problem Solving / Q000502:physiology*