title: The protective effect of montelukast sodium on carbon tetrachloride induced hepatopathy in rat.
abstract: OBJECTIVE
  This study investigates the effects of montelukast sodium (MK) (CysLTLT1 receptor antagonist) on CCl(4)induced hepatopathy on rat.
  
  
  METHODS
  We worked on 4 groups of 10 Wistar male rats each. The groups received as follows: group I (control group) - saline, group II - MK 5mg/kg/day i.p. for 5 days, group III - MK 5mg/kg/day i.p., 1 day prior to and 4 days concomitantly with CCl(4) p.o., 0.3ml/Kg/day and group IV - CCl(4), p.o., 0.3ml/Kg/day for 4 days. One day after the last administration, samples of blood were taken and alanine aminotransferase (ALT), total bilirubin (TB), direct bilirubin (DB), malondialdehyde (MDA), catalase (CAT) as well as total antioxidant capacity (TAC) were determined. The histopathological exam was performed. We also determined superoxide dismutase (SOD), MDA, CAT and GSH in liver homogenate.
  
  
  RESULTS
  Compared to group IV, group III exhibited statistically significant lower levels of ALT (318+/-15.75 versus 203.14+/-10.28 UI, p<0.0001), TB (3.16+/-0.30 versus 1.99+/-0.08mg/dl, p<0.0001), MDA in blood and in liver homogenate (4.98+/-1.71 versus 2.15+/-1.18nmol/ml, p=0.0004) and higher levels of SOD and CAT. Histopathologically, group IV presented important macro- and micro-vesicular hepatic steatosis and group III preserved lobular histoarchitecture and had less severe cellular lesions.
  
  
  CONCLUSIONS
  MK exhibits a partial hepatoprotective effect on rats treated with CCl(4).
authors.affiliation: Department of Pharmacology, University of Medicine and Pharmacy, GRIGORE T. POPA, IASI, Romania. magdacuciur@gmail.com
authors.forename: Magdalena
authors.initials: M
authors.lastname: Cuciureanu
authors.forename: Irina-Draga
authors.initials: ID
authors.lastname: Căruntu
authors.forename: Ofelia
authors.initials: O
authors.lastname: Păduraru
authors.forename: Bogdan
authors.initials: B
authors.lastname: Stoica
authors.forename: Luminita
authors.initials: L
authors.lastname: Jerca
authors.forename: Eduard
authors.initials: E
authors.lastname: Crauciuc
authors.forename: Mihai
authors.initials: M
authors.lastname: Nechifor
mesh_terms: D000085:Acetates / Q000494:pharmacology*; D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001663:Bilirubin / Q000378:metabolism; D002251:Carbon Tetrachloride / Q000633:toxicity*; D002374:Catalase / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury; D003521:Cyclopropanes; D008099:Liver / Q000187:drug effects*; D008107:Liver Diseases / Q000201:enzymology / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D011804:Quinolines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013440:Sulfides; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000085:Acetates; D003521:Cyclopropanes; D011804:Quinolines; D013440:Sulfides; D008315:Malondialdehyde; D002251:Carbon Tetrachloride; D002374:Catalase; D013482:Superoxide Dismutase; D000410:Alanine Transaminase; C093875:montelukast; D001663:Bilirubin