title: [Discrepancy between Gleason score of needle biopsies and radical prostatectomy specimens--current situation of general pathologists].
abstract: We retrospectively reviewed the discrepancy in Gleason score between needle biopsy and radical prostatectomy specimens. Specimens from 153 patients who underwent radical retropubic prostatectomy at Gifu University Hospital and 9 community-based institutions between January 2001 and December 2005, were studied. Gleason score was determined by the general pathologist at each institution. The coincidence rate of Gleason score between biopsy and prostatectomy specimens was 49.7%. In contrast, 37.4% of biopsy specimens were undergraded. In biopsy specimens given a Gleason score of 5 or less, the Gleason score was coincident or undergraded compared with prostatectomy specimens. In biopsy specimens given a Gleason score of 6, the coincidence rate was 39.6%. In 56% in biopsy specimens of cancers with a Gleason score of 6 the Gleason score was undergraded compared with the prostatectomy specimen. In this group, extra-prostatic extention was found significantly more often than in other groups (p = 0.04). In patients, who underwent extended biopsy, or had a more positive biopsy core (> or = 25%), the coincidence rate was significantly greater (p = 0.03). We should be aware of the limitations of Gleason scores based on biopsy specimens, and give treatment opinions careful consideration.
authors.affiliation: Gifu Prostate Cancer Study Group.
authors.forename: Taku
authors.initials: T
authors.lastname: Kato
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nakano
authors.forename: Hiromi
authors.initials: H
authors.lastname: Uno
authors.forename: Kensaku
authors.initials: K
authors.lastname: Seike
authors.forename: Keitaro
authors.initials: K
authors.lastname: Kojima
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Kubota
authors.forename: Takahiro
authors.initials: T
authors.lastname: Goto
authors.forename: Naoki
authors.initials: N
authors.lastname: Yamamoto
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Ehara
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kanimoto
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Takashi
authors.initials: T
authors.lastname: Deguchi
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000473:pathology*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology*; D012189:Retrospective Studies