title: Effect of tacrine, amiridine, akatinol memantine, and triazolam on phosphorylation, structure, and assembly of microtubules from brain microtubular proteins in Alzheimer diseases.
abstract: In in vitro experiments, amiridine in concentration of 100, 200, and 300 microM restored disturbed structure of microtubules assembled from tubulin and microtubule-associated proteins isolated from the brain of patients with Alzheimer disease. Tacrine in a concentration of 100, 250, and 500 microM inhibited phosphorylation of tubulin and microtubule-associated proteins isolated from the brain of patients with Alzheimer disease, while memantine and amiridine in the specified concentrations had no effect on phosphorylation.
authors.affiliation: Laboratory of Neurochemistry, Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow. shevt@dio.ru
authors.forename: P N
authors.initials: PN
authors.lastname: Shevtsov
authors.forename: E F
authors.initials: EF
authors.lastname: Shevtsova
authors.forename: G Sh
authors.initials: GSh
authors.lastname: Burbaeva
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D000634:Aminoquinolines / Q000494:pharmacology*; D001921:Brain / Q000166:cytology* / Q000187:drug effects* / Q000378:metabolism; D015259:Dopamine Agents / Q000494:pharmacology; D018757:GABA Modulators / Q000494:pharmacology; D006801:Humans; D008559:Memantine / Q000494:pharmacology*; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism* / Q000648:ultrastructure; D018697:Nootropic Agents / Q000494:pharmacology; D010766:Phosphorylation; D013619:Tacrine / Q000494:pharmacology*; D014229:Triazolam / Q000494:pharmacology*
chemical_list: D000634:Aminoquinolines; D015259:Dopamine Agents; D018757:GABA Modulators; D008869:Microtubule-Associated Proteins; D018697:Nootropic Agents; D014229:Triazolam; D013619:Tacrine; C049860:amiridine; D008559:Memantine