Sequential reactions with Grubbs catalyst and AD-mix-alpha/beta using PDMS thimbles.
Incompatible Grubbs catalyst and an osmium dihydroxylation catalyst were site-isolated from each other using polydimethylsiloxane thimbles. The Grubbs catalyst was added to the interior of the thimbles, and AD-mix-alpha/beta was added to the exterior. Organic substrates readily fluxed through the walls of the thimbles and reacted with each catalyst. A series of cascade reactions were developed including those with intermediates possessing low boiling points or that were foul smelling.
Mwangi
Martin T
MT
Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.
Schulz
Michael D
MD
Bowden
Ned B
NB
D000096:Acetone / Q000737:chemistry*; D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D004129:Dimethylpolysiloxanes / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D009992:Osmium / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry; D020002:tert-Butyl Alcohol / Q000737:chemistry*
C412621:1-butyl-3-methylimidazolium hexafluorophosphate; D000475:Alkenes; D004129:Dimethylpolysiloxanes; D007093:Imidazoles; D009942:Organometallic Compounds; D014867:Water; D000096:Acetone; D009992:Osmium; D012428:Ruthenium; D020002:tert-Butyl Alcohol