title: Coarse-grained modeling of interactions of lipid bilayers with supports.
abstract: We characterize the differences between supported and unsupported lipid bilayer membranes using a mesoscopic simulation model and a simple particle-based realization for a flat support on to which the lipids are adsorbed. We show that the nanometer roughness of the support affects membrane binding strength very little. We then compare the lipid distributions and pressure profiles of free and supported membranes. The surface localization of the proximal leaflet breaks the symmetry seen in a free bilayer, and we quantify the entropic penalty for binding and the increased lateral compression modulus.
authors.affiliation: Graduate Group in Biophysics, University of California, Davis, California 95616, USA.
authors.forename: Matthew I
authors.initials: MI
authors.lastname: Hoopes
authors.forename: Markus
authors.initials: M
authors.lastname: Deserno
authors.forename: Margie L
authors.initials: ML
authors.lastname: Longo
authors.forename: Roland
authors.initials: R
authors.lastname: Faller
mesh_terms: D004548:Elasticity; D008051:Lipid Bilayers / Q000737:chemistry*; D008956:Models, Chemical; D011312:Pressure; D013499:Surface Properties; D014867:Water / Q000737:chemistry
chemical_list: D008051:Lipid Bilayers; D014867:Water