SOS regulation of qnrB expression.
In the sequence upstream from qnrB (but not qnrA or qnrS) is a LexA binding site. qnrB was shown to be under SOS control by demonstrating that quinolone susceptibility decreased with increasing temperature in a strain with a recA441(Ts) allele, whereas qnrB expression increased in response to ciprofloxacin or mitomycin C in strains with an intact lexA gene.
Wang
Minghua
M
Massachusetts General Hospital, Boston, Massachusetts, USA.
Jacoby
George A
GA
Mills
Debra M
DM
Hooper
David C
DC
D000483:Alleles; D001483:Base Sequence; D004269:DNA, Bacterial / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D029968:Escherichia coli Proteins / Q000235:genetics*; D015870:Gene Expression / Q000235:genetics / Q000502:physiology*; D016685:Mitomycin / Q000494:pharmacology; D008969:Molecular Sequence Data; D019384:Nucleic Acid Synthesis Inhibitors / Q000494:pharmacology; D010957:Plasmids / Q000235:genetics; D015363:Quinolones / Q000494:pharmacology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013014:SOS Response, Genetics / Q000235:genetics*
D004269:DNA, Bacterial; D029968:Escherichia coli Proteins; D019384:Nucleic Acid Synthesis Inhibitors; C485384:Qnr protein, E coli; D015363:Quinolones; D016685:Mitomycin