Expression and prognostic significance of PDCD4 in human epithelial ovarian carcinoma.
BACKGROUND
Programmed cell death 4 (PDCD4) is a newly discovered tumor suppressor. The aim of this study was to investigate the expression and prognostic significance of PDCD4 in epithelial ovarian cancer.


METHODS
PDCD4 expression in 20 normal human ovaries and 69 serous ovarian tumors was examined by RT-PCR and immunohistochemistry. The relationships between PDCD4 expression, clinicopathological data and patient survival were evaluated.


RESULTS
PDCD4 expression was found to be lost or significantly lower in serous cystadenocarcinomas compared with that in normal ovaries and serous cystadenomas (p<0.05). The loss or reduction of PDCD4 expression in serous cystadenocarcinomas was significantly associated with higher pathological grade (p=0.0118) and poorer disease-specific survival of patients (p=0.0011). Multivariant Cox regression analysis revealed that PDCD4 expression was an independent prognostic factor for serous cystadenocarcinoma.


CONCLUSIONS
Lost or reduced PDCD4 expression is associated with the progression of serous cystadenocarcinomas and may serve as an important prognostic marker.
Wang
Xiaoyan
X
Institute of Immunology, School of Medicine, Shandong University, Jinan 250012, Shandong, P. R. China.
Wei
Zengtao
Z
Gao
Fei
F
Zhang
Xia
X
Zhou
Chengjun
C
Zhu
Faliang
F
Wang
Qun
Q
Gao
Qi
Q
Ma
Chunhong
C
Sun
Wensheng
W
Kong
Beihua
B
Zhang
Lining
L
D000328:Adult; D000368:Aged; D051017:Apoptosis Regulatory Proteins / Q000096:biosynthesis* / Q000235:genetics; D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D018284:Cystadenocarcinoma, Serous / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D010053:Ovary / Q000378:metabolism; D011379:Prognosis; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D016601:RNA-Binding Proteins / Q000096:biosynthesis* / Q000235:genetics
D051017:Apoptosis Regulatory Proteins; D014408:Biomarkers, Tumor; C114487:PDCD4 protein, human; D012333:RNA, Messenger; D016601:RNA-Binding Proteins