title: Intrabronchial foreign body extracted with tranilast and corticosteroid.
abstract: We present a case of intrabronchial foreign body buried in granulation tissue, which was successfully extracted administrating tranilast (n-[3,4-dimethoxycinnamoyl] anthranilic acid), suppressing collagen synthesis by fibroblasts in keloid and hypertrophic scars, and corticosteroid. Bronchoscopy of a 74-year-old man showed the nail was buried in reactive granulation tissue and could not be observed from the surface. Tranilast at 300 mg/day and methylprednisolone at 250 mg/day were prescribed for 4 days, followed by a reduction of the corticosteroid to 40 mg/day for 3 days. Seven days later, the granulation tissue and mucosal edema were diminished, and the nail was successfully extracted.
authors.affiliation: Department of Thoracic Surgery, Nagahama City Hospital, Nagahama, Japan. yaterada@ex.biwa.ne.jp
authors.forename: Yasuji
authors.initials: Y
authors.lastname: Terada
authors.forename: Yasuto
authors.initials: Y
authors.lastname: Sakaguchi
authors.forename: Tomoya
authors.initials: T
authors.lastname: Kono
authors.forename: Jun
authors.initials: J
authors.lastname: Nohara
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Noguchi
mesh_terms: D000368:Aged; D001980:Bronchi; D001999:Bronchoscopy; D004334:Drug Administration Schedule; D004487:Edema / Q000209:etiology / Q000517:prevention & control; D005547:Foreign Bodies / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D006097:Granulation Tissue; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D062367:ortho-Aminobenzoates / Q000008:administration & dosage*
chemical_list: D062367:ortho-Aminobenzoates; C012293:tranilast; D008775:Methylprednisolone