Aging: a sirtuin shake-up?
The yeast sirtuin (Sir2) is a histone deacetylase that modulates yeast replicative life span by suppressing genome instability through chromatin modification. In this issue, Oberdoerffer et al. (2008) report that SIRT1, the mammalian ortholog of Sir2, is involved in DNA damage-induced chromatin reorganization, which promotes genome stability in mammalian cells.
Vijg
Jan
J
Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA. jvijg@aecom.yu.edu
Maslov
Alexander Y
AY
Suh
Yousin
Y
D000375:Aging / Q000235:genetics*; D000818:Animals; D004260:DNA Repair; D042822:Genomic Instability; D037761:Sirtuins / Q000235:genetics*; D015003:Yeasts
D037761:Sirtuins