Development of Fe3O4-poly(L-lactide) magnetic microparticles in supercritical CO2.
The Fe(3)O(4)-poly(L-lactide) (Fe(3)O(4)-PLLA) magnetic microparticles were successfully prepared in a process of solution-enhanced dispersion by supercritical CO(2) (SEDS), and their morphology, particle size, magnetic mass content, surface atom distribution and magnetic properties were characterized. Indomethacin (Indo) was used as a drug model to produce drug-polymer magnetic composite microparticles. The resulting Fe(3)O(4)-PLLA microparticles with mean size of 803 nm had good magnetic property and a saturation magnetization of 24.99 emu/g. The X-ray photoelectron spectroscopy (XPS) test indicated that most of the Fe(3)O(4) were encapsulated by PLLA, which indicated that the Fe(3)O(4)-PLLA magnetic microparticles had a core-shell structure. After further loading with drug, the Indo-Fe(3)O(4)-PLLA microparticles had a bigger mean size of 901 nm, and the Fourier transform infrared spectrometer (FTIR) analysis demonstrated that the SEDS process was a typical physical coating process to produce drug-polymer magnetic composite microparticles, which is favorable for drugs since there is no change in chemistry. The in vitro cytotoxicity test showed that the Fe(3)O(4)-PLLA magnetic microparticles had no cytotoxicity and were biocompatible, which means there is potential for biomedical application.
Chen
Ai-Zheng
AZ
College of Materials Science and Engineering, Sichuan University, Chengdu, Sichuan 610064, China.
Kang
Yun-Qing
YQ
Pu
Xi-Ming
XM
Yin
Guang-Fu
GF
Li
Yi
Y
Hu
Jun-Yan
JY
D000818:Animals; D001672:Biocompatible Materials; D002245:Carbon Dioxide; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004339:Drug Compounding; D016503:Drug Delivery Systems / Q000379:methods*; D005290:Ferric Compounds / Q000737:chemistry*; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage; D008280:Magnetics; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry*
D001672:Biocompatible Materials; D005290:Ferric Compounds; D011091:Polyesters; D002245:Carbon Dioxide; C000499:ferric oxide; C033616:poly(lactide); D007213:Indomethacin