Solubility of selected derivatives of 1,4-benzodiazepine-2-one in the presence of PVP.
Pharmaceutical availability of diazepam, oxazepam and nitrazepam from solid dispersions of PVP have been studied in comparison to those of the corresponding physical mixtures and pure benzodiazepines. The derivatives of 1,4-benzodiazepin-2-one are poorly water soluble drugs. The properties of diazepam-, oxazepam- and nitrazepam-PVP solid dispersions have been determined by the methods of differential scanning calorimetry (DSC) and X-ray diffraction. The effect of PVP on the solubility of selected derivatives of 1,4-benzodiazepin-2-one has been studied. The solubility of diazepam, oxazepam and nitrazepam from its solid dispersion has been found to increase in presence of PVP.
Cwiertnia
Barbara
B
Poznań University of Medical Sciences, Department of Inorganic and Analytical Chemistry, 6 Grunwaldzka Str., 60-780 Poznań, Poland. cbarbara@interia.pl
D001570:Benzodiazepinones / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D011205:Povidone / Q000737:chemistry*; D012995:Solubility; D014961:X-Ray Diffraction
D001570:Benzodiazepinones; D011205:Povidone