[Candidiasis in the experimental model of ulcerative colitis].
In the present study on animal model of ulcerative colitis the influence of fungal colonization on the severity of inflammatory lesions in the colon and the course of their healing was evaluated. The results of our studies revealed, that significant fungal colonization (over 10(4) CFU/ml) delayed ulcer healing in the colon. It corresponded with the decrease of colonic blood flow (CBF) in the region of lesions and increase of interleukin (IL)-1beta, tumor necrosis factor(TNF)-alpha level in the serum. Introduction of antifungal therapy (fluconazole) or probiotic in rats inoculated with Candida accelerated the process of ulcer healing in the colon, expressed through the reduction of macro- and microscopic lesions in the colon and decrease of MPO, IL-beta TNF-alpha serum level.
Zwolińska-Wcisło
Małgorzata
M
Klinika Gastroenterologii, Hepatologii i Chorób Zakaźnych, Colegium Medicum Uniwersytetu Jagiellońskiego, Kraków. mzwcislo@su.krakow.pl
Sliwowski
Zbigniew
Z
Drozdowicz
Danuta
D
Kwiecień
Sławomir
S
Mazurkiewicz-Janik
Magdalena
M
Trojanowska
Danuta
D
Rudnicka-Sosin
Lucyna
L
Mach
Tomasz
T
Budak
Alicja
A
Brzozowski
Tomasz
T
Konturek
Stanisław J
SJ
Pawlik
Wiesław W
WW
D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use; D002175:Candida / Q000302:isolation & purification*; D002177:Candidiasis / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology*; D003093:Colitis, Ulcerative / Q000097:blood / Q000188:drug therapy / Q000382:microbiology*; D003106:Colon / Q000098:blood supply / Q000382:microbiology; D004195:Disease Models, Animal; D015725:Fluconazole / Q000627:therapeutic use; D053583:Interleukin-1beta / Q000097:blood; D008297:Male; D019936:Probiotics / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D000935:Antifungal Agents; D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha; D015725:Fluconazole