title: First total synthesis of hinckdentine A.
abstract: We have accomplished the first total synthesis of (+/-)-hinckdentine A (1). The key steps are m-CPBA oxidation of 2-arylindole followed by acid-mediated Mannich-type C-C bond formation of 2-hydroxyindolin-3-one, seven-membered ring closure, and regioselective tribromination.
authors.affiliation: Meiji Pharmaceutical University, 2-522-1 Noshio Kiyose, Tokyo 204-8588, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Higuchi
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Sato
authors.forename: Mei
authors.initials: M
authors.lastname: Tsuchimochi
authors.forename: Kenta
authors.initials: K
authors.lastname: Sugiura
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Hatori
authors.forename: Tomomi
authors.initials: T
authors.lastname: Kawasaki
mesh_terms: D015394:Molecular Structure; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D011799:Quinazolines; C485801:hinckdentine A