Zamamidines A and B, new manzamine alkaloids from the sponge Amphimedon species.
New manzamine alkaloids, zamamidines A (1) and B (2), have been isolated from an Okinawan marine sponge Amphimedon species. The structures and stereochemistry of 1 and 2 were elucidated from the spectroscopic data and conformational analysis. Zamamidines A (1) and B (2) are the first manzamine alkaloids possessing a second beta-carboline ring via an ethylene unit at N-2 of manzamine H and 1,2,3,4-tetrahydromanzamine B, respectively.
Takahashi
Yohei
Y
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Kubota
Takaaki
T
Fromont
Jane
J
Kobayashi
Jun'ichi
J
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D000818:Animals; D002227:Carbazoles / Q000737:chemistry* / Q000302:isolation & purification; D018360:Crystallography, X-Ray; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D011161:Porifera / Q000737:chemistry*; D013045:Species Specificity; D013237:Stereoisomerism
D000470:Alkaloids; D002227:Carbazoles; D006576:Heterocyclic Compounds, 4 or More Rings; C534969:zamamidine A; C534970:zamamidine B