title: Effect of pulmonary autograft transplantation in the surgical treatment of aortic valve disease.
abstract: BACKGROUND
  Aortic root replacement with pulmonary autograft (Ross procedure) has the advantages of good haemodynamics and growth potential without the need for anticoagulation. In this study, we reviewed our experience of the Ross procedure for patients with aortic valve disease.
  
  
  METHODS
  From October 1994 to January 2005, 42 Ross procedures were performed in our centre. There were 30 males and 12 females. The mean age was 28 +/- 15 years (range, 5-56 years). Congenital heart disease (CHD) with aortic valve stenosis (AS) and/or aortic valve insufficiency (AI) in 40 cases including one associated with ventricular septal defect (VSD), degenerated aortic valve disease with AS in 1 and subacutive bacterial endocarditis (SBE) with AI in 1 were studied. The diagnosis was made by ultracardiography (UCG) in all patients. The mean aortic valve annulus diameter (AVD) was (2.45 +/- 0.31) cm and pulmonary valve annulus diameter (MPVD) was (2.34 +/- 0.21) cm. All patients had normal pulmonary valves. The New York Heart Association (NYHA) function class was II in 36 cases and III in 6 cases. The operation was performed under moderate hypothermic cardiopulmonary bypass (CPB) with aortic root replacement using pulmonary autograft and pulmonary valve replacement with a homograft.
  
  
  RESULTS
  There was no early hospital mortality. Postoperative UCG showed normal aortic valve function in all our patients. The mean gradient across the aortic valve was (6.11 +/- 0.12) mmHg. The left ventricular diastole diameter (LVDD) decreased significantly from (62 +/- 5) mm to (56 +/- 3) mm (P < 0.001). The mean postoperative left ventricular ejective fraction (LVEF) was 0.49 +/- 0.23. All patients were in NYHA class I-II. Follow-up was completed in 38 cases for a mean period of 3.2 years (range 1-10 years). All survivors were in NYHA class I with normal neo-aortic and pulmonary valve function. One patient died after secondary operation due to homograft fungal endocarditis 1 year after the Ross procedure. The cause of death was uncontrolled bleeding. Another patient suffered from cardiogenic shock and was on extracorporeal membrane oxygenation (ECMO) for 10 days postoperatively. This patient was subsequently self-discharged from hospital due to financial issues and he was excluded from follow-up.
  
  
  CONCLUSIONS
  The Ross procedure is an excellent technique to treat aortic valve disease. Our data show that it can be performed safely with good early and mid-term clinical outcomes.
authors.affiliation: Department of Cardiac Surgery, Institute of Heart, Lung and Blood Vessel, Anzhen Hospital, Capital Medical University, Beijing 100029, China. Liwenbin65@vip.sina.com
authors.forename: Wen-Bin
authors.initials: WB
authors.lastname: Li
authors.forename: Xiu-Fang
authors.initials: XF
authors.lastname: Xu
authors.forename: Jian-Qun
authors.initials: JQ
authors.lastname: Zhang
authors.forename: Shi-Qiu
authors.initials: SQ
authors.lastname: Song
authors.forename: Jin-Feng
authors.initials: JF
authors.lastname: Peng
authors.forename: Sheng-Xun
authors.initials: SX
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Hai-Po
authors.initials: HP
authors.lastname: Zhou
authors.forename: Zhu-Heng
authors.initials: ZH
authors.lastname: Wang
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Liu
authors.forename: Qi-Wen
authors.initials: QW
authors.lastname: Zhou
mesh_terms: D000293:Adolescent; D000328:Adult; D001022:Aortic Valve Insufficiency / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011664:Pulmonary Valve / Q000637:transplantation*; D014182:Transplantation, Autologous