title: Citreamicins with potent gram-positive activity.
abstract: Two new xanthone antibiotics, citreamicin delta (1) and epsilon (2), with potent activity against Gram-positive pathogens including multidrug-resistant Staphylococcus aureus (MDRSA) were discovered. Compounds 1 and 2 exhibited MIC values < 1 microg/mL versus a number of resistant strains. The compounds were obtained from EtOAc extracts of Streptomyces vinaceus and were purified by countercurrent chromatography and reversed-phase HPLC. Their structures were elucidated using primarily NMR and mass spectroscopy.
authors.affiliation: AMRI, Bothell Research Center, 18804 North Creek Parkway, Bothell, Washington 98011, USA.
authors.forename: D Craig
authors.initials: DC
authors.lastname: Hopp
authors.forename: Dennis J
authors.initials: DJ
authors.lastname: Milanowski
authors.forename: Joshua
authors.initials: J
authors.lastname: Rhea
authors.forename: Daniel
authors.initials: D
authors.lastname: Jacobsen
authors.forename: John
authors.initials: J
authors.lastname: Rabenstein
authors.forename: Chris
authors.initials: C
authors.lastname: Smith
authors.forename: Khadidja
authors.initials: K
authors.lastname: Romari
authors.forename: Midori
authors.initials: M
authors.lastname: Clarke
authors.forename: Linda
authors.initials: L
authors.lastname: Francis
authors.forename: Macarena
authors.initials: M
authors.lastname: Irigoyen
authors.forename: Michele
authors.initials: M
authors.lastname: Luche
authors.forename: Grant J
authors.initials: GJ
authors.lastname: Carr
authors.forename: Ulla
authors.initials: U
authors.lastname: Mocek
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D010080:Oxazoles; C534409:citreamicin delta; C534408:citreamicin epsilon