Protective and therapeutic effects of glyprolines in psychoemotional stress induced by cholecystokinin-4 injection.
Experiments on outbred albino male rats showed that psychoemotional stress induced by intraperitoneal injection of cholecystokinin-4 (100 microg/kg) increased anxiety, impaired orientation and exploration activities in the elevated plus-maze and hole-board tests, and increased the level of depression of Porsolt test. Preliminary intranasal administration of glyprolines (15 min before cholecystokinin) in a dose of 3.7 micromol/kg prevented the development of stress-induced behavioral disturbances. Administration of peptides 30 min after cholecystokinin-4, i.e., to rats with developed behavioral disturbances, almost completely abolished these disturbances.
Edeeva
S E
SE
Department of Human and Animal Physiology, Biological Faculty of M. V. Lomonosov Moscow State University. edeeva_saglara@mail.ru
Kopylova
G N
GN
Bakaeva
Z V
ZV
Samona
G E
GE
Umarova
B A
BA
Guseva
A A
AA
D000818:Animals; D001007:Anxiety / Q000139:chemically induced / Q000188:drug therapy; D001522:Behavior, Animal / Q000187:drug effects; D003863:Depression / Q000139:chemically induced; D004151:Dipeptides / Q000627:therapeutic use*; D005106:Exploratory Behavior / Q000187:drug effects; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D009842:Oligopeptides / Q000627:therapeutic use*; D011392:Proline / Q000031:analogs & derivatives* / Q000627:therapeutic use; D051381:Rats; D013315:Stress, Psychological / Q000139:chemically induced / Q000188:drug therapy*; D013758:Tetragastrin
D004151:Dipeptides; D009842:Oligopeptides; C113164:prolyl-glycyl-proline; D013758:Tetragastrin; C015248:glycylproline; D011392:Proline