Amelioration of experimental diabetic neuropathy and gastropathy in rats following the oral administration of an herbal formulation of Diabo-SS extract.
The aqueous and methanolic extract of a preparation; Diabo-SS (100 mg/kg b.wt) was administered to streptozotocin-induced diabetic animals. The aqueous Diabo-SS extract showed significantly (P < .001) higher anti-diabetic activity than the methanolic extract. Continuous administration of the aqueous extract of Diabo-SS reduced the plasma glucose level by 40% on 60th day. The tail flick latency (TFL) and gastric transit percentages were significantly higher in diabetic controls versus normal control animals.
Sabu
M C
MC
Department of Research and Development, Vaidyaratnam Oushadhasala, Ollur, 680 322 Thrissur, Kerala, India. sabu_mc@rediffmail.com
Priya
Thambi T
TT
D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000188:drug therapy*; D003929:Diabetic Neuropathies / Q000188:drug therapy*; D005767:Gastrointestinal Diseases / Q000188:drug therapy* / Q000209:etiology; D005772:Gastrointestinal Transit / Q000187:drug effects; D008297:Male; D010147:Pain Measurement; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D013623:Tail
D001786:Blood Glucose; D010936:Plant Extracts