title: Lipid flip-flop driven mechanical and morphological changes in model membranes.
abstract: We study, using dissipative particle dynamics simulations, the effect of active lipid flip-flop on model fluid bilayer membranes. We consider both cases of symmetric as well as asymmetric flip-flops. Symmetric flip-flop leads to a steady state of the membrane with an effective temperature higher than that of the equilibrium membrane and an effective surface tension lower than that of the equilibrium membrane. Asymmetric flip-flop leads to transient conformational changes in the membrane in the form of bud or blister formation, depending on the flip rate.
authors.affiliation: Department of Physics, Indian Institute of Technology Madras, Chennai 600 036, India. sanoop@physics.iitm.ac.in
authors.forename: Sanoop
authors.initials: S
authors.lastname: Ramachandran
authors.forename: P B Sunil
authors.initials: PB
authors.lastname: Kumar
authors.forename: Mohamed
authors.initials: M
authors.lastname: Laradji
mesh_terms: D001696:Biomechanical Phenomena; D002462:Cell Membrane / Q000737:chemistry* / Q000378:metabolism*; D050356:Lipid Metabolism; D008055:Lipids / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation
chemical_list: D008055:Lipids