title: Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin.
abstract: NKp46+CD3- natural killer lymphocytes isolated from blood, lymphoid organs, lung, liver and uterus can produce granule-dependent cytotoxicity and interferon-gamma. Here we identify in dermis, gut lamina propria and cryptopatches distinct populations of NKp46+CD3- cells with a diminished capacity to degranulate and produce interferon-gamma. In the gut, expression of the transcription factor RORgammat, which is involved in the development of lymphoid tissue-inducer cells, defined a previously unknown subset of NKp46+CD3- lymphocytes. Unlike RORgammat- lamina propria and dermis natural killer cells, gut RORgammat+NKp46+ cells produced interleukin 22. Our data show that lymphoid tissue-inducer cells and natural killer cells shared unanticipated similarities and emphasize the heterogeneity of NKp46+CD3- cells in innate immunity, lymphoid organization and local tissue repair.
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, Université de la Méditerranée, Institut National de la Santé et de la Recherche Médicale, U631, 13288 Marseille, France.
authors.forename: Carmelo
authors.initials: C
authors.lastname: Luci
authors.forename: Ana
authors.initials: A
authors.lastname: Reynders
authors.forename: Ivaylo I
authors.initials: II
authors.lastname: Ivanov
authors.forename: Celine
authors.initials: C
authors.lastname: Cognet
authors.forename: Laurent
authors.initials: L
authors.lastname: Chiche
authors.forename: Lionel
authors.initials: L
authors.lastname: Chasson
authors.forename: Jean
authors.initials: J
authors.lastname: Hardwigsen
authors.forename: Esperanza
authors.initials: E
authors.lastname: Anguiano
authors.forename: Jacques
authors.initials: J
authors.lastname: Banchereau
authors.forename: Damien
authors.initials: D
authors.lastname: Chaussabel
authors.forename: Marc
authors.initials: M
authors.lastname: Dalod
authors.forename: Dan R
authors.initials: DR
authors.lastname: Littman
authors.forename: Eric
authors.initials: E
authors.lastname: Vivier
authors.forename: Elena
authors.initials: E
authors.lastname: Tomasello
mesh_terms: D000818:Animals; D017252:CD3 Complex / Q000378:metabolism; D002455:Cell Division; D020405:Dermis / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis; D007378:Interleukins / Q000096:biosynthesis; D007413:Intestinal Mucosa / Q000276:immunology*; D008213:Lymphocyte Activation / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D055627:Natural Cytotoxicity Triggering Receptor 1 / Q000276:immunology; D055611:Natural Killer T-Cells / Q000276:immunology*; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D010581:Peyer's Patches / Q000276:immunology; D018168:Receptors, Retinoic Acid / Q000235:genetics / Q000502:physiology*; D011988:Receptors, Thyroid Hormone / Q000235:genetics / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*; D000097043:Interleukin-22
chemical_list: D017252:CD3 Complex; D007371:Interferon-gamma; D007378:Interleukins; D055627:Natural Cytotoxicity Triggering Receptor 1; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D018168:Receptors, Retinoic Acid; D011988:Receptors, Thyroid Hormone; D014157:Transcription Factors; D000097043:Interleukin-22; C112260:NCR1 protein, human; C539900:RORC protein, human; C539901:Rorc protein, mouse