Catalytic enantioselective intermolecular hydroacylation: rhodium-catalyzed combination of beta-S-aldehydes and 1,3-disubstituted allenes.
A rhodium(I) catalyst incorporating the Me-DuPhos ligand promotes enantioselective intermolecular hydroacylation between beta-S-aldehydes and 1,3-disubstituted allenes. The nonconjugated enone products are obtained in good yields and with high enantioselectivities.
Osborne
James D
JD
Department of Chemistry, University of Oxford, Chemical Research Laboratory, Mansfield Road, Oxford, UK.
Randell-Sly
Helen E
HE
Currie
Gordon S
GS
Cowley
Andrew R
AR
Willis
Michael C
MC
D000447:Aldehydes / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D002621:Chemistry / Q000379:methods*; D008024:Ligands; D008670:Metals / Q000737:chemistry; D008956:Models, Chemical; D015394:Molecular Structure; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism; D013696:Temperature
D000447:Aldehydes; D000475:Alkenes; D008024:Ligands; D008670:Metals; D002244:Carbon; D012238:Rhodium