title: Gonadotropins and female sex steroid hormones in cyst fluid and serum from patients with ovarian tumors.
abstract: The objective of the present study was to determine the concentrations of LH, FSH, 17beta-estradiol and progesterone in ovarian cyst fluid and serum from patients with benign and malignant ovarian tumors and to assess the correlation of the gonadotropin and female sex steroid hormone concentrations with menopausal and tumor status. Ovarian cyst fluid and blood samples were prospectively collected from 103 patients with ovarian tumors. Seventy-four of the patients had benign ovarian tumors while 29 patients had malignant ovarian tumors. Malignant ovarian tumors showed significantly higher LH and FSH cyst fluid concentrations compared to concentrations from patients with benign tumors. Within the malignant subset, LH and FSH concentrations correlated with increasing FIGO stage and grade. Furthermore, LH and FSH cyst fluid concentrations showed strong correlations (r > 0.62) with serum concentrations in case of malignant tumors, especially in postmenopausal women, but not in case of benign tumors. The highest gonadotropin concentrations were observed in cyst fluid from malignant ovarian tumors. The most probable explanation for this is an increased vascular permeability within the cysts. Supportive evidence for such an increased vascular permeability is our previous finding of significantly higher VEGF concentrations in cyst fluid from malignant ovarian tumors. The possibility of ectopic production of LH and FSH by malignant ovarian tissue cannot completely be ruled out.
authors.affiliation: Department of Chemical Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. c.thomas@ace.umcn.nl
authors.forename: C M G
authors.initials: CM
authors.lastname: Thomas
authors.forename: E A
authors.initials: EA
authors.lastname: Boss
authors.forename: H
authors.initials: H
authors.lastname: Boonstra
authors.forename: D
authors.initials: D
authors.lastname: van Tienoven
authors.forename: C G J
authors.initials: CG
authors.lastname: Sweep
authors.forename: L F A G
authors.initials: LF
authors.lastname: Massuger
mesh_terms: D020420:Cyst Fluid / Q000737:chemistry*; D004958:Estradiol / Q000032:analysis / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000032:analysis / Q000097:blood; D012739:Gonadal Steroid Hormones / Q000032:analysis* / Q000097:blood; D006062:Gonadotropins / Q000032:analysis* / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000032:analysis / Q000097:blood; D008593:Menopause; D010051:Ovarian Neoplasms / Q000097:blood / Q000378:metabolism*; D011374:Progesterone / Q000032:analysis / Q000097:blood; D011446:Prospective Studies; D011863:Radioimmunoassay
chemical_list: D012739:Gonadal Steroid Hormones; D006062:Gonadotropins; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone