Comparison of sublingual tablets with nitroglycerin complexed with beta-cyclodextrin or titrated with crosspovidone--technological approach.
Fast disintegrating sublingual tablets containing nitroglycerin either complexed with beta-cyclodextrin (NTG-CD) or titrated with crosspovidone (NTG-CP) were prepared using Starch 1500 or StarLac as disintegrants. Regarding disintegration time and stability of the active substance Starch 1500 was more appropriate for NTG-CD while for NTG-CP StarLac was suitable. Stability of NTG was better in NTG-CD tablets than in NTG-CP tablets, however, within 12 months of storage at 25 degrees C the loss of NTG in all formulations was still greater than 10%.
Centkowska
Katarzyna
K
Department of Pharmaceutical Technology, Medical University of Gdańsk, 107 Gen. J. Hallera St., 80-416 Gdańsk, Poland.
Sznitowska
Małgorzata
M
D000286:Administration, Sublingual; D004355:Drug Stability; D006801:Humans; D005996:Nitroglycerin / Q000008:administration & dosage* / Q000032:analysis / Q000737:chemistry; D013607:Tablets; D013678:Technology, Pharmaceutical; D047392:beta-Cyclodextrins / Q000737:chemistry*
D013607:Tablets; D047392:beta-Cyclodextrins; D005996:Nitroglycerin; C031215:betadex