3q27 aberrations in a childhood ovary teratoma with associated malignant germ cell component.
Cytogenetic studies of childhood ovary tumors have been poorly described. In the present article, the cytogenetic findings of an ovarian teratoma with malignant germ cell (yolk-sac) component occurring in an 8-year-old female are detailed. GTG-banding showed a karyotype of 46,XX, t(3;20)(q27;q13.3) [4]/46,XX, del3q27 [3]/46,XX [30]. Previous studies have demonstrated common sites of loss of heterozygosity at 3q27-q28 region in different types of cancer, suggesting the presence of tumor suppressor genes within this region.
Brassesco
María Sol
MS
Department of Pediatrics, Radiology Division, Division of Pediatric Oncology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil. marsol@rge.fmrp.usp.br
Castro-Gamero
Angel Mauricio
AM
Valera
Elvis Terci
ET
Neder
Luciano
L
Elias
Jorge
J
Tone
Luiz Gonzaga
LG
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020360:Neoadjuvant Therapy; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000235:genetics* / Q000601:surgery; D011859:Radiography; D012729:Sex Chromosome Aberrations; D013724:Teratoma / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000235:genetics* / Q000601:surgery