title: Magnesiation of pyridine N-oxides via iodine or bromine-magnesium exchange: a useful tool for functionalizing pyridine N-oxides.
abstract: Iodo- or 2-bromopyridine N-oxides were readily magnesiated with i-PrMgCl x LiCl via the iodine or bromine-magnesium exchange. The bromine adjacent to pyridine N-oxide (at the 2- or 6-position) can be regioselectively magnesiated in the presence of other position substituted halogens. This method was tested in various substituted pyridine N-oxide systems, and has been successfully applied to the total synthesis of caerulomycins E and A.
authors.affiliation: Department of Chemistry, Beijing Normal University, Beijing, 100875, China. xinfangduan@vip.163.com
authors.forename: Xin-Fang
authors.initials: XF
authors.lastname: Duan
authors.forename: Zi-Qian
authors.initials: ZQ
authors.lastname: Ma
authors.forename: Fang
authors.initials: F
authors.lastname: Zhang
authors.forename: Zhan-Bin
authors.initials: ZB
authors.lastname: Zhang