Chaotic model and memory in single calcium-activated potassium channel kinetics.
Ion channels are pores formed by proteins and responsible for carrying ion fluxes through cellular membranes. The ion channels can assume conformational states thereby controlling ion flow. Physically, the conformational transitions from one state to another are associated with energy barriers between them and are dependent on stimulus, such as, electrical field, ligands, second messengers, etc. Several models have been proposed to describe the kinetics of ion channels. The classical Markovian model assumes that a future transition is independent of the time that the ion channel stayed in a previous state. Others models as the fractal and the chaotic assume that the rate of transitions between the states depend on the time that the ionic channel stayed in a previous state. For the calcium activated potassium channels of Leydig cells the R/S Hurst analysis has indicated that the channels are long-term correlated with a Hurst coefficient H around 0.7, showing a persistent memory in this kinetic. Here, we applied the RS analysis to the opening and closing dwell time series obtained from simulated data from a chaotic model proposed by L. Liebovitch and T. Tóth [J. Theor. Biol. 148, 243 (1991)] and we show that this chaotic model or any model that treats the set of channel openings and closings as independent events is inadequate to describe the long-term correlation (memory) already described for the experimental data.
Bandeira
Heliovânio T
HT
Department of Statistic and Informatics, Federal Rural University of Pernambuco, R. Dom Manuel de Medeiros, s/n, Dois Irmãos, 52171-030 Recife, PE, Brazil.
Barbosa
Catão T F
CT
De Oliveira
Regina A Campos
RA
Aguiar
José F
JF
Nogueira
Romildo A
RA
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D002478:Cells, Cultured; D003198:Computer Simulation; D005246:Feedback / Q000502:physiology; D015640:Ion Channel Gating / Q000502:physiology*; D007985:Leydig Cells / Q000502:physiology*; D017774:Long-Term Potentiation / Q000502:physiology*; D008297:Male; D051379:Mice; D008954:Models, Biological; D017711:Nonlinear Dynamics; D024681:Potassium Channels, Calcium-Activated / Q000502:physiology*
D024681:Potassium Channels, Calcium-Activated