[Uterine transplantation: animal and human studies].
Many cases of not life saving transplanted organs were described with the aim of improving quality of life. Uterus graft could be an alternative solution to adoption or surrogacy for women who have uterine factor infertility. Different animals' studies with mouse, sheep or monkey showed feasibility of the surgical technique with large vessels patch. One case of human uterine transplant has been reported but failed. Cold storage of the uterus in protective solution has been explored with mouse, sheep and human. Only pregnancy after uterus graft by syngenic mouse has been published. Results about pregnancy after allograft with sheep or monkey are necessary before pregnancy after human uterus graft becomes a reality.
Gauthier
T
T
Service de gynécologie-obstétrique, hôpital de la Mère et de l'Enfant, CHU de Limoges, 8, avenue Dominique-Larrey, 87000 Limoges, France. gauthiertristan@yahoo.fr
Hardeman
S
S
Piver
P
P
Aubard
Y
Y
D000818:Animals; D015925:Cryopreservation; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000601:surgery*; D051379:Mice; D011788:Quality of Life; D012756:Sheep; D016896:Treatment Outcome; D014599:Uterus / Q000002:abnormalities / Q000098:blood supply / Q000637:transplantation*