title: Comparison of pulmonary artery and aortic transpulmonary thermodilution for monitoring of cardiac output in patients with severe heart failure: validation of a novel method.
abstract: OBJECTIVE
  Hemodynamic monitoring with the pulmonary artery catheter is frequently used in the management of severe heart failure. For measurement of cardiac output (CO), transpulmonary thermodilution (TPTD) has recently been adopted into clinical practice as an alternative to pulmonary artery thermodilution. However, no data have been published on the comparability of the two methods for patients with severely reduced left ventricular function. Our objective was to evaluate the correlation between these two methods of CO determination in patients with severe left ventricular dysfunction.
  
  
  METHODS
  Prospective observational clinical study.
  
  
  METHODS
  Cardiological intermediate care unit and medical intensive care unit of a university hospital.
  
  
  METHODS
  Twenty-nine patients with left ventricular ejection fraction <35% and symptoms of heart failure (New York Heart Association class III-IV).
  
  
  METHODS
  None.
  
  
  RESULTS
  The two methods of intermittent CO measurement were compared by simultaneously recording the results of pulmonary artery thermodilution and TPTD after injection of a cold saline bolus. Measurements were performed when clinically necessary. A total of 325 data pairs were analyzed. Mean CO of both methods was 4.4 L/min with a bias of 0.45 L/min (2 SD 1.20 L/min), resulting in a percentage error of 27.3%.
  
  
  CONCLUSIONS
  In patients with severely impaired left ventricular function, measurement of CO by TPTD provides valid results.
authors.affiliation: Department of Internal Medicine B, Division of Cardiology, Pneumology, and Critical Care Medicine, University of Greifswald, Greifswald, Germany.
authors.forename: Sigrun
authors.initials: S
authors.lastname: Friesecke
authors.forename: Annegret
authors.initials: A
authors.lastname: Heinrich
authors.forename: Peter
authors.initials: P
authors.lastname: Abel
authors.forename: Stephan B
authors.initials: SB
authors.lastname: Felix
mesh_terms: D001013:Aorta, Thoracic; D002302:Cardiac Output; D005260:Female; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D011446:Prospective Studies; D011651:Pulmonary Artery; D012720:Severity of Illness Index; D013815:Thermodilution / Q000379:methods*; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology*