Characterization of the role of TCR gammadelta in NK cell accumulation during viral liver inflammation.
Polyinosinic-polyctidylic acid (Poly I:C) is a viral RNA mimic that can induce immune responses similar to that seen during viral infection. Although poly I:C administration into mice is associated increased NK cell infiltrates in the liver, the mechanisms underlying increased hepatic NK cell accumulation in response to poly I:C administration are incompletely defined. In the current study, we have identified a novel and important role for gammadelta T cells in driving the accumulation and activation of NK cells in the liver during poly I:C-mediated viral liver infection. Specifically, NK cell accumulation but not activation in gammadelta T cell deficient mice following poly I:C administration was significantly attenuated in comparison to that seen in poly I:C-treated wildtype mice. The ability of gammadelta T cells to promote NK cell accumulation and activation in the liver may be virus-specific since NK cell accumulation in the liver was not altered by TCR gammadelta deficiency following adenovirus administration.
Gardner
Tommy
T
Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center-Shreveport, 1501 Kings Highway, Shreveport, LA 71130-3932, USA.
Chen
Qingling
Q
Jin
Yijun
Y
Ajuebor
Maureen N
MN
D000256:Adenoviridae / Q000235:genetics / Q000378:metabolism; D000818:Animals; D006524:Hepatitis, Viral, Animal / Q000276:immunology* / Q000473:pathology; D007249:Inflammation / Q000276:immunology*; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology*; D008099:Liver / Q000166:cytology / Q000276:immunology / Q000821:virology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D011070:Poly I-C / Q000276:immunology*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics / Q000276:immunology*
D016692:Receptors, Antigen, T-Cell, gamma-delta; D011070:Poly I-C