title: Multifidone: a novel cytotoxic lathyrane-type diterpene having an unusual six-membered A ring from Jatropha multifida.
abstract: Chemical examination of the stems of Jatropha multifida afforded a novel lathyrane-type diterpene, multifidone, having an unusual six-membered A ring. The structure of the compound was determined from detailed analysis of its 1D and 2D NMR spectra and X-ray crystallographic analysis. Its cytotoxicity was measured on four different cancerous cell lines.
authors.affiliation: Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad, India. biswanathdas@yahoo.com
authors.forename: Biswanath
authors.initials: B
authors.lastname: Das
authors.forename: Kongara Ravinder
authors.initials: KR
authors.lastname: Reddy
authors.forename: Bommena
authors.initials: B
authors.lastname: Ravikanth
authors.forename: Tuniki Venugopal
authors.initials: TV
authors.lastname: Raju
authors.forename: Balasubramanian
authors.initials: B
authors.lastname: Sridhar
authors.forename: Patan Usman
authors.initials: PU
authors.lastname: Khan
authors.forename: Janapala Venkateswara
authors.initials: JV
authors.lastname: Rao
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D031286:Jatropha / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; C530347:lathyrane