title: Asymmetric Friedel-Crafts alkylations of indoles with dialkyl 3-oxoprop-1-enylphosphonates: organocatalytic enantioselective synthesis of alpha-indolyl phosphonates.
abstract: Organocatalytic enantioselective synthesis of alpha-indolyl phosphonates has been successfully carried out via asymmetric Friedel-Crafts alkylation of substituted indoles with (E)-dialkyl 3-oxoprop-1-enylphosphonates in 48-82% yield and 73-96% ee.
authors.affiliation: Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, Hubei 430079, China.
authors.forename: Ying-Cen
authors.initials: YC
authors.lastname: Guo
authors.forename: Dong-Ping
authors.initials: DP
authors.lastname: Li
authors.forename: Yu-Ling
authors.initials: YL
authors.lastname: Li
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Wang
authors.forename: Wen-Jing
authors.initials: WJ
authors.lastname: Xiao
mesh_terms: D000478:Alkylation; D002384:Catalysis; D002625:Chemistry, Organic; D007211:Indoles / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D063065:Organophosphonates / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D007211:Indoles; D063065:Organophosphonates