Role of P2X receptors in positive inotropic effect of rat myocardium during ontogeny.
Experiments with selective agonists and antagonists of purinoceptors allowed us to evaluate the subtype of P2X receptors. We showed that the myocardium of 14- 100-day-old rats contains functionally active P2X1 receptors. These receptors are involved in the realization of the positive inotropic effect of the atria and ventricles. Selective P2X1 receptor agonist beta,gamma-methylene-ATP induced a dose-dependent increase in the strength of atrial and ventricular contractions. P2X1 receptor antagonist TNP-ATP abolished the effect of the agonist in rats of all age groups.
Zverev
A A
AA
Department of Anatomy, Physiology, and Human Health Protection, Tatar State Humanitarian Pedagogical University, Kazan. alekcei5@rambler.ru
Anikina
T A
TA
Sitdicov
F G
FG
D000255:Adenosine Triphosphate / Q000031:analogs & derivatives / Q000378:metabolism; D000375:Aging / Q000502:physiology*; D000818:Animals; D006321:Heart / Q000033:anatomy & histology / Q000254:growth & development*; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism*; D058910:Purinergic P2 Receptor Agonists; D058919:Purinergic P2 Receptor Antagonists; D051381:Rats; D018048:Receptors, Purinergic P2 / Q000378:metabolism*; D058469:Receptors, Purinergic P2X
D058910:Purinergic P2 Receptor Agonists; D058919:Purinergic P2 Receptor Antagonists; D018048:Receptors, Purinergic P2; D058469:Receptors, Purinergic P2X; C005147:5'-adenylyl (beta,gamma-methylene)diphosphonate; C045674:2',3'-O-(2,4,6-trinitro-cyclohexadienylidine)adenosine 5'-triphosphate; D000255:Adenosine Triphosphate