title: Colorectal surgery in octogenarian patients--outcomes and predictors of morbidity.
abstract: BACKGROUND
  Surgery for elderly patients pose a constant challenge. This study aims to review the outcome and find predictors of adverse outcome in octogenarians undergoing major colorectal resection for cancer.
  
  
  METHODS
  A review of 121 octogenarians who underwent colorectal cancer surgery between September 1992 and May 2008 was performed. Comorbidities were quantified using the weighted Charlson Comorbidity Index and ASA classification. CR-POSSUM scores and ACPGBI scores and the predicted mortality rates were calculated. Outcome measures were morbidity rates and 30-day mortality rates.
  
  
  RESULTS
  The patients had a mean age of 83.5 years (range, 80-99). The mean index of comorbidity was 3.1 (2-7) and 12.5% of patients were classified ASA III and above. The mean predicted mortality rate based on CR-POSSUM and ACPGBI scoring models were 11.2% and 5.4% respectively. The overall observed morbidity rate was 30.7% and 30-day mortality was 1.6. Factors found on bivariate analysis to be significantly associated with an increased risk of morbidity were tumor presenting with complication, comorbid coronary heart disease, serum urea levels, ASA classification > or =3 and comorbidity index 3 of 5 > or = 5. Multivariate analysis revealed the latter two factors to be independent predictors of morbidity.
  
  
  CONCLUSIONS
  Octogenarians undergoing major colorectal resection have an acceptable perioperative morbidity and mortality rate and survival rate and should not be denied surgery based on age alone. Comorbidity index scores and ASA scores are useful tools to identify poor risk patients.
authors.affiliation: Department of Surgery, Jichi Medical School Saitama Medical Centre, 1-847 Amanumacho, Omiyaku, Saitamashi, Saitamaken, 330-8503, Japan. kokyangtan@gmail.com
authors.forename: K Y
authors.initials: KY
authors.lastname: Tan
authors.forename: Y
authors.initials: Y
authors.lastname: Kawamura
authors.forename: K
authors.initials: K
authors.lastname: Mizokami
authors.forename: J
authors.initials: J
authors.lastname: Sasaki
authors.forename: S
authors.initials: S
authors.lastname: Tsujinaka
authors.forename: T
authors.initials: T
authors.lastname: Maeda
authors.forename: F
authors.initials: F
authors.lastname: Konishi
mesh_terms: D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000601:surgery*; D003107:Colorectal Surgery; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D009017:Morbidity; D015999:Multivariate Analysis; D019990:Perioperative Care; D011183:Postoperative Complications / Q000453:epidemiology; D016896:Treatment Outcome