Therapeutic potential of interleukin-15: a myokine involved in muscle wasting and adiposity.
Since the discovery of IL-15 and its role in T-cell proliferation in 1994, different studies on the effects of the cytokine on metabolic effects have been performed. These studies have mainly been involved with the metabolic pathways involved in lipid and protein metabolism. The present review summarises the metabolic effects of IL-15 at different target tissues and the possibilities and potential for therapeutic interventions based on the cytokine's roles in obesity and wasting.
Argilés
Josep M
JM
Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028-Barcelona, Spain.
López-Soriano
Francisco J
FJ
Busquets
Sílvia
S
D000818:Animals; D049109:Cell Proliferation; D016503:Drug Delivery Systems; D006801:Humans; D019409:Interleukin-15 / Q000276:immunology / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000187:drug effects / Q000503:physiopathology; D009765:Obesity / Q000188:drug therapy / Q000503:physiopathology; D013601:T-Lymphocytes / Q000276:immunology; D019282:Wasting Syndrome / Q000188:drug therapy / Q000503:physiopathology
D019409:Interleukin-15