Inheritance of Colorectal Cancer.
Inheritance is involved in up to one third of colon cancer cases. Highly penetrant inherited syndromes account for approximately 3%, while more common, but less penetrant inherited factors play a role in the remainder. Approaches to recognizing each of these categories and syndromes, using genetic testing for diagnosis where indicated, and accomplishing proper cancer screening and surveillance will be outlined in this review.
Burt
Randall
R
Huntsman Cancer Institute and Department of Medicine, University of Utah, Salt Lake City, Utah.