title: Usefulness of PET/CT for detecting a second primary cancer after treatment for squamous cell carcinoma of the head and neck.
abstract: OBJECTIVE
  Patients with squamous cell carcinoma of the head and neck have been reported to have a high rate of second primary cancer of the upper aerodigestive tract. This study was performed to determine whether positron emission tomography/computed tomography (PET/CT) is useful for detecting a second primary cancer after treatment for squamous cell carcinoma of the head and neck.
  
  
  METHODS
  The PET/CT findings in 279 consecutive patients (211 men, 68 women; mean age 62 years) who had been treated for squamous cell carcinomas of the head and neck were examined and compared with the findings obtained by other imaging modalities, the biopsy results, and the clinical data.
  
  
  RESULTS
  Thirty second primary cancers were documented in 28 of the 279 subjects. Based on PET/CT findings, the overall risk of a second primary cancer in 1 year was 9.9% and the risk in the upper aerodigestive tract region was 6.8% (19/279).
  
  
  CONCLUSIONS
  PET/CT enabled early detection of a second cancer in patients treated for head and neck cancer.
authors.affiliation: Department of Radiology, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Bayarkhuu
authors.initials: B
authors.lastname: Bold
authors.forename: Yongnan
authors.initials: Y
authors.lastname: Piao
authors.forename: Yuji
authors.initials: Y
authors.lastname: Murata
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Kishino
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Shibuya
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000628:therapy*; D005260:Female; D006258:Head and Neck Neoplasms / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000000981:diagnostic imaging; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed