title: Low numbers of intestinal Shiga toxin-producing E. coli correlate with a poor prognosis in sheep infected with bovine leukemia virus.
abstract: Healthy ruminants carry intestinal Shiga toxin (Stx)-producing Escherichia coli (STEC). Stx has antiviral activities in vitro and STEC numbers correlate with reduced early viremia in sheep experimentally infected with bovine leukemia virus (BLV). This study assessed the impact of intestinal STEC on BLV-induced disease for one year post-BLV-challenge. High STEC scores (CFU/g feces x frequency of STEC-positive samples) correlated with good health, whereas poor weight gain, distress, and tumor development occurred only among animals with low STEC scores. STEC carriage was associated with increased percentages of B cells in peripheral blood.
authors.affiliation: Department of Microbiology, Molecular Biology and Biochemistry, University of Idaho, Moscow, ID 83844-3052, USA.
authors.forename: Witold A
authors.initials: WA
authors.lastname: Ferens
authors.forename: Julius
authors.initials: J
authors.lastname: Haruna
authors.forename: Rowland
authors.initials: R
authors.lastname: Cobbold
authors.forename: Carolyn J
authors.initials: CJ
authors.lastname: Hovde
mesh_terms: D000818:Animals; D006800:Deltaretrovirus Infections / Q000382:microbiology / Q000662:veterinary*; D007422:Intestines / Q000382:microbiology*; D001909:Leukemia Virus, Bovine / Q000502:physiology*; D008297:Male; D012756:Sheep; D012757:Sheep Diseases / Q000382:microbiology*; D054323:Shiga-Toxigenic Escherichia coli / Q000502:physiology*