title: Science, hormesis and regulation.
abstract: While hormesis is an intriguing scientific hypothesis, this paper argues that it is not yet an acceptable basis for policy-making. Two reasons are given for this assessment. First, although hormesis has suggestive explanatory power, it does not yet have the predictive successes that indicate a general reliability sufficient for policy-making. Second, the regulatory agenda for chemical exposures is usually focused, for good ethical reasons, on protecting people from involuntary and potentially harmful exposures, rather than focused on maximizing public health benefits.
authors.affiliation: University of Tennessee, 808 McClung Tower, Knoxville, Tennessee 37996-0480, USA. hdouglas@utk.edu
authors.forename: H
authors.initials: H
authors.lastname: Douglas
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004787:Environmental Pollution / Q000009:adverse effects / Q000331:legislation & jurisprudence; D006291:Health Policy / Q000331:legislation & jurisprudence*; D006801:Humans; D012106:Research; D014118:Toxins, Biological / Q000627:therapeutic use* / Q000633:toxicity*; D014481:United States
chemical_list: D014118:Toxins, Biological