title: Metabolites from the endophytic mitosporic Dothideomycete sp. LRUB20.
abstract: The endophytic mitosporic Dothideomycete sp. LRUB20 was found to produce pyrone derivatives, dothideopyrones A-D (1, 3, 4, and 5), together with seven known compounds, including questin (9), asterric acid (10), methyl asterrate (11), sulochrin (12), and eugenitin (13), 6-hydroxymethyleugenitin (14), and cis, trans-muconic acid (15). Dothideopyrone D (5) and its acetate derivative 6 exhibited moderate cytotoxic activity. This is the first report on a naturally occurring muconic acid, which is commonly known as a biomarker in environments after exposure to benzene and phenol (or derivatives). Interestingly, the LRUB20 fungus could produce muconic acid in relatively high yield (47.8mg/L). The utility of endophytic fungi in the field of white biotechnology is discussed.
authors.affiliation: Chulabhorn Research Institute and Chulabhorn Graduate Institute, Vipavadee-Rangsit Highway, Bangkok 10210, Thailand.
authors.forename: Porntep
authors.initials: P
authors.lastname: Chomcheon
authors.forename: Suthep
authors.initials: S
authors.lastname: Wiyakrutta
authors.forename: Nongluksna
authors.initials: N
authors.lastname: Sriubolmas
authors.forename: Nattaya
authors.initials: N
authors.lastname: Ngamrojanavanich
authors.forename: Chulabhorn
authors.initials: C
authors.lastname: Mahidol
authors.forename: Somsak
authors.initials: S
authors.lastname: Ruchirawat
authors.forename: Prasat
authors.initials: P
authors.lastname: Kittakoop
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D003904:Mitosporic Fungi / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure; D011753:Pyrones / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D011753:Pyrones