J-difference lactate editing at 3.0 Tesla in the presence of strong lipids.
OBJECTIVE
To implement in vivo detection of lactate in the presence of lipids by proton magnetic resonance spectroscopy at a 3 Tesla (T) field strength for potential applications in human tumors outside of the brain.


METHODS
The BASING J-difference sequence was implemented in the presence of high lipid concentrations in phantoms and in vivo at 3 Tesla.


RESULTS
The effectiveness of the lactate editing scheme is demonstrated in phantoms containing both lactate and lipids and in vivo in ischemic induced human muscle.


CONCLUSIONS
The ability of the BASING J-difference technique to detect lactate in the presence of strong lipid signals outside the brain at 3T is feasible. This robust technique should permit noninvasive lactate measurements in human tumors to investigate its potential as a prognostic indicator.
Smith
Mari A
MA
Department of Medical Physics, Mail Box 84, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA. smithm3@mskcc.org
Koutcher
Jason A
JA
Zakian
Kristen L
KL
D006801:Humans; D019344:Lactic Acid / Q000032:analysis*; D008055:Lipids / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D018482:Muscle, Skeletal / Q000737:chemistry; D019047:Phantoms, Imaging; D012815:Signal Processing, Computer-Assisted
D008055:Lipids; D019344:Lactic Acid