A new antiangiogenic C24 oxylipin from the soft coral Sinularia numerosa.
A new oxylipin, 15-hydroxy-tetracosa-6,9,12,16,18-pentaenoic acid (15-HTPE; 1) was isolated as an inhibitor of tube-formation from the soft coral Sinularia numerosa. Its structure was elucidated by means of spectral analysis and chemical degradation. 15-HTPE inhibited tube formation of EA.hy926 cells at the concentration of 20-40 microM.
Yamashita
Takahiro
T
Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
Nakao
Yoichi
Y
Matsunaga
Shigeki
S
Oikawa
Tsutomu
T
Imahara
Yukimitsu
Y
Fusetani
Nobuhiro
N
D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D054883:Oxylipins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D020533:Angiogenesis Inhibitors; D054883:Oxylipins