title: A case of disseminated Nocardia farcinica diagnosed through DNA sequencing in a kidney transplantation patient.
abstract: Nocardia is a rare gram-positive bacteria causing opportunistic infection, and belongs to the aerobic Actinomycetes group. As the mortality in the immunocompromised patients with nocardiosis is high, early diagnosis and treatment is very important. However, clinical manifestations of infection caused by Nocardia are very variable and early diagnosis is limited by the difficulty in obtaining specimens and its isolation. Rapid diagnosis of Nocardia infection may allow for earlier effective therapy, thus improving patient outcome. We report a case of Nocardia farcinica diagnosed by DNA sequencing through blood culture in a renal transplant recipient with severe pneumonia and multiple brain abscesses.
authors.affiliation: Department of Internal Medicine, School of Medicine, Inje University, Busan, South Korea.
authors.forename: B S
authors.initials: BS
authors.lastname: Park
authors.forename: Y J
authors.initials: YJ
authors.lastname: Park
authors.forename: Y J
authors.initials: YJ
authors.lastname: Kim
authors.forename: S W
authors.initials: SW
authors.lastname: Kang
authors.forename: Y H
authors.initials: YH
authors.lastname: Kim
authors.forename: J H
authors.initials: JH
authors.lastname: Shin
authors.forename: Y C
authors.initials: YC
authors.lastname: Yoon
authors.forename: Y W
authors.initials: YW
authors.lastname: Kim
mesh_terms: D004269:DNA, Bacterial / Q000032:analysis*; D003937:Diagnosis, Differential; D006801:Humans; D007668:Kidney / Q000382:microbiology*; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009615:Nocardia / Q000235:genetics* / Q000302:isolation & purification; D009617:Nocardia Infections / Q000175:diagnosis* / Q000382:microbiology; D018410:Pneumonia, Bacterial / Q000175:diagnosis* / Q000382:microbiology; D017422:Sequence Analysis, DNA / Q000379:methods*; D014057:Tomography, X-Ray Computed
chemical_list: D004269:DNA, Bacterial