Alkaloids from roots of Stemona sessilifolia and their antitussive activities.
Protostemonamide ( 1), a new protostemonine-type alkaloid, and 12 known compounds were isolated from the roots of Stemona sessilifolia. Their structures were elucidated by 1 D and 2 D NMR spectral and other spectroscopic studies. The main alkaloidal constituents, protostemonine ( 2), stemospironine ( 4), and maistemonine ( 7), showed significant antitussive activity in a citric acid-induced guinea pig cough model following peripheral administration; stemonamine ( 11) had antitussive activity following i. c. v. administration.
Yang
Xin-Zhou
XZ
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, PR China.
Zhu
Jian-Yu
JY
Tang
Chun-Ping
CP
Ke
Chang-Qiang
CQ
Lin
Ge
G
Cheng
Tin-Yan
TY
Rudd
John A
JA
Ye
Yang
Y
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D000818:Animals; D000996:Antitussive Agents / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D001381:Azepines / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D019343:Citric Acid; D003371:Cough / Q000139:chemically induced / Q000188:drug therapy*; D004195:Disease Models, Animal; D006168:Guinea Pigs; D015394:Molecular Structure; D008517:Phytotherapy; D010936:Plant Extracts; D018517:Plant Roots; D041901:Stemonaceae / Q000737:chemistry*
D000470:Alkaloids; D000996:Antitussive Agents; D001381:Azepines; D010936:Plant Extracts; C539441:protostemonamide; D019343:Citric Acid; D015107:4-Butyrolactone