Novel imprinted transcripts from the Dlk1-Gtl2 intergenic region,  Mico1 and Mico1os, show circadian oscillations.
Most of the known imprinted genes are assembled into clusters that share common imprinting control regions (ICRs). Non-coding transcripts are often associated with ICRs and implicated in imprinting regulation. We undertook a systematic search for transcripts originating from the Dlk1-Gtl2 intergenic region that contains the ICR for the chromosome 12 imprinted cluster and identified two overlapping transcripts expressed from opposite strands exclusively from the maternal chromosome. These novel imprinted transcripts most likely represent non-coding RNAs and are located telomeric to the IG DMR, extending the proximal boundary of the region of maternal-specific transcription. Their expression is tissue-specific and shows diurnal and circadian oscillations.Therefore, we named these novel transcripts maternal intergenic circadian oscillating 1 (Mico1) and Mico1, opposite strand (Mico1os).
Labialle
Stéphane
S
Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
Croteau
Sylvie
S
Bélanger
Valérie
V
McMurray
Erin N
EN
Ruan
Xuan
X
Moussette
Sanny
S
Jonnaert
Maud
M
Schmidt
Jennifer V
JV
Cermakian
Nicolas
N
Naumova
Anna K
AK
D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000378:metabolism; D002135:Calcium-Binding Proteins; D002940:Circadian Rhythm / Q000235:genetics*; D017124:Conserved Sequence; D021901:DNA, Intergenic / Q000235:genetics*; D004622:Embryo, Mammalian / Q000378:metabolism; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D018392:Genomic Imprinting / Q000235:genetics*; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*; D008322:Mammals / Q000235:genetics; D051379:Mice; D008969:Molecular Sequence Data; D011506:Proteins / Q000235:genetics*; D062085:RNA, Long Noncoding; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D022661:RNA, Untranslated / Q000235:genetics*
D002135:Calcium-Binding Proteins; D021901:DNA, Intergenic; C512925:Dlk1 protein, mouse; D036341:Intercellular Signaling Peptides and Proteins; C422882:MEG3 non-coding RNA, mouse; D011506:Proteins; D062085:RNA, Long Noncoding; D012333:RNA, Messenger; D022661:RNA, Untranslated