The Alzheimer beta-amyloid (Abeta(1-39)) dimer in an implicit solvent.
Oligomers of Abeta peptides are suspected as the underlying cause of Alzheimer disease. Knowledge of their structural properties could therefore lead to a deeper understanding of the mechanism behind the outbreak of this disease. As a step in this direction we have studied Abeta dimers by all-atom molecular dynamics simulations. Equilibrated structures at 300 K were clustered into different families with similar structural features. The dominant cluster has parallel N-terminals and a well defined segment Leu17-Ala21 that are stabilized by salt bridges between Lys28 of one chain and either Glu22 or Asp23 of the other chain. The formation of these salt bridges may be the limiting step in oligomerization and fibrillogenesis.
Anand
Priya
P
Department of Biophysics, Panjab University, Chandigarh-160014, India. p.anand@daad-alumni.de
Nandel
Fateh S
FS
Hansmann
Ulrich H E
UH
D000595:Amino Acid Sequence; D016229:Amyloid beta-Peptides / Q000737:chemistry*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D055503:Protein Multimerization; D020836:Protein Structure, Quaternary; D012997:Solvents / Q000737:chemistry*; D013696:Temperature
D016229:Amyloid beta-Peptides; D012997:Solvents