title: Quantification of BK polyoma viruria in Japanese children and adults with hemorrhagic cystitis complicating stem cell transplantation.
abstract: Polyoma BK virus (BKV) is frequently found in the urine of stem cell transplantation (SCT) patients with hemorrhagic cystitis (HC), but also occurs in SCT patients without HC. How BK viruria relates to the development of HC in SCT patients, especially in children, has not yet been fully evaluated. In the present study, we analyzed the relationship of several factors including urinary BKV load to HC development in children and adults undergoing SCT. We employed a quantitative PCR assay and evaluated 37 patients (aged 9 months-62 years) of whom 12 developed HC and 25 did not. Older age was a risk factor for the development of HC; however, other factors such as sex, primary disease, type of SCT, conditioning regimen and aGVHD were not. Peak urinary BKV values in HC patients were not higher than those in non-HC patients. Severity of HC also did not correlate with urinary BKV loads. However, in some patients who secreted higher urinary BKV loads, the peak loads were closely related with the onset of HC. Higher BKV loads may be a risk factor for the development of HC in conjunction with other coexisting factors.
authors.affiliation: Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Japan. ktanaka@sapmed.ac.jp
authors.forename: Kaori
authors.initials: K
authors.lastname: Tanaka
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Hori
authors.forename: Naoki
authors.initials: N
authors.lastname: Hatakeyama
authors.forename: Masaki
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Rumiko
authors.initials: R
authors.lastname: Takayama
authors.forename: Yuko
authors.initials: Y
authors.lastname: Yoto
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Suzuki
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Hayashi
authors.forename: Yukiho
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ikeda
authors.forename: Tadao
authors.initials: T
authors.lastname: Ishida
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsutsumi
mesh_terms: D000328:Adult; D000367:Age Factors; D044466:Asian People; D001739:BK Virus / Q000302:isolation & purification*; D002648:Child; D003556:Cystitis / Q000473:pathology / Q000821:virology*; D006801:Humans; D027601:Polyomavirus Infections / Q000150:complications*; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D014412:Tumor Virus Infections / Q000150:complications*; D014556:Urine / Q000821:virology