title: A comparative study of 131I and 177Lu labeled somatostatin analogues for therapy of neuroendocrine tumours.
abstract: This work analysed the influence of the chelating group and radioligand on somatostatin analogues in vivo and in vitro properties. The presence of DOTA in the radioiodinated peptide produced a labeled analogue with similar blood kinetics and biodistribution to (177)Lu-DOTATATE and with lower abdominal uptake than (131)I-TATE. In addition, (131)I-DOTATATE showed significative tumour uptake, despite not so persistent after 24h. (131)I-DOTATATE can represent a cost-effective alternative to lutetium labeled peptide for neuroendocrine tumours therapy.
authors.affiliation: Radiopharmacy Directory, Nuclear and Energetic Research Institute (IPEN), Av. Lineu Prestes, 2242, Cidade Universitária, Butantã, CEP 05508-000, São Paulo, Brazil. ebaraujo@ipen.br
authors.forename: E B
authors.initials: EB
authors.lastname: de Araújo
authors.forename: J S
authors.initials: JS
authors.lastname: Caldeira Filho
authors.forename: L T
authors.initials: LT
authors.lastname: Nagamati
authors.forename: E
authors.initials: E
authors.lastname: Muramoto
authors.forename: M T
authors.initials: MT
authors.lastname: Colturato
authors.forename: R M
authors.initials: RM
authors.lastname: Couto
authors.forename: P B
authors.initials: PB
authors.lastname: Pujatti
authors.forename: J
authors.initials: J
authors.lastname: Mengatti
authors.forename: C P G
authors.initials: CP
authors.lastname: Silva
mesh_terms: D000818:Animals; D002614:Chelating Agents; D006573:Heterocyclic Compounds, 1-Ring; D007457:Iodine Radioisotopes; D008187:Lutetium; D051379:Mice; D018358:Neuroendocrine Tumors / Q000000981:diagnostic imaging* / Q000532:radiotherapy; D010599:Pharmacokinetics; D011868:Radioisotopes; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D013004:Somatostatin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D014018:Tissue Distribution
chemical_list: D002614:Chelating Agents; D006573:Heterocyclic Compounds, 1-Ring; D007457:Iodine Radioisotopes; D011868:Radioisotopes; D019275:Radiopharmaceuticals; C071349:1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid; D013004:Somatostatin; D008187:Lutetium