title: The effect of praziquantel applied per os on selected haematological and biochemical indices in common carp (Cyprinus carpio L.).
abstract: The aim of the study was to assess the effects of the anthelminthic, praziquantel, on the haematological and biochemical indices of the blood of common carp (Cyprinus carpio L.). Fish were divided into six groups: two groups received 30 mg kg(-1) body weight (bw) of praziquantel, and two groups were given 50 mg kg(-1) bw of praziquantel mixed into the heat-treated amyloid vehicle. Fish in the remaining two groups were given only the amyloid vehicle and were used as controls. Fish were examined either 24 or 96 h after administration. Praziquantel treatment was characterised by a significantly lower erythrocyte count, haemoglobin level, packed cell volume and total protein at both dose levels after 24 h compared with the controls, but these parameters were similar to the control values at 96 h. The activity of alanine aminotransferase (ALT) was significantly higher after 96 h in the treated groups, which could be attributed to slight hepatocyte damage caused by praziquantel. However, the differences between the treated and the control groups were not great, and we presumed that they were reversible.
authors.affiliation: Research Institute of Fish Culture and Hydrobiology, University of South Bohemia Ceské Budejovice, Zatisi 728/II, 389 25 Vodnany, Czech Republic. sudova@vurh.jcu.cz
authors.forename: Eliska
authors.initials: E
authors.lastname: Sudová
authors.forename: Veronika
authors.initials: V
authors.lastname: Piacková
authors.forename: Hana
authors.initials: H
authors.lastname: Kroupová
authors.forename: Martin
authors.initials: M
authors.lastname: Pijácek
authors.forename: Zdenka
authors.initials: Z
authors.lastname: Svobodová
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000704:Analysis of Variance; D000818:Animals; D000871:Anthelmintics / Q000633:toxicity*; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis; D002347:Carps / Q000097:blood* / Q000378:metabolism; D004912:Erythrocytes / Q000187:drug effects; D006400:Hematocrit / Q000662:veterinary; D008297:Male; D011223:Praziquantel / Q000633:toxicity*
chemical_list: D000871:Anthelmintics; D001786:Blood Glucose; D001798:Blood Proteins; D011223:Praziquantel; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase