title: Blood pressure and heart rate patterns during sleep are altered in preterm-born infants: implications for sudden infant death syndrome.
abstract: OBJECTIVE
  Preterm infants are at an increased risk of sudden infant death syndrome, which may result from immature autonomic control of heart rate and blood pressure. Previous studies have demonstrated that preterm infants have altered heart rate and blood pressure control at term-equivalent age; however, little information is available beyond this age. The aim of this study was to determine the effect of preterm birth on heart rate and blood pressure control over the first 6 months of life after reaching term-equivalent age, including the age at which sudden infant death syndrome risk is increased, to understand the pathogenesis of sudden infant death syndrome.
  
  
  METHODS
  Preterm (n=25) and term (n=20) infants were studied longitudinally at 2 to 4 weeks', 2 to 3 months', and 5 to 6 months' term-corrected age by using daytime polysomnography. A photoplethysmographic cuff (Finometer) around the infant's wrist measured blood pressure during quiet and active sleep.
  
  
  RESULTS
  Blood pressure was lower in the preterm group during both quiet and active sleep at all ages studied. In contrast, there were no differences between groups in heart rate. Within the infants in the preterm group, blood pressure averaged lower at 2 to 3 months' corrected age compared with both 2 to 4 weeks' and 5 to 6 months' corrected age and was lower in quiet sleep compared with active sleep at all ages studied. Heart rate decreased with increasing age and was lower in quiet sleep compared with active sleep at 5 to 6 months' corrected age.
  
  
  CONCLUSIONS
  Sleep state and age affect heart rate and blood pressure patterns in prematurely born infants over the first 6 months of term-corrected age. It is notable that preterm infants had persistently lower blood pressure compared with age-matched term infants, signifying long-term alterations in cardiovascular control in infants born prematurely.
authors.affiliation: Ritchie Centre for Baby Health Research, Monash Institute of Medical Research, Monash University, Melbourne, Level 5, Monash Medical Centre, 246 Clayton Rd, Clayton, Victoria 3168, Australia.
authors.forename: Nicole B
authors.initials: NB
authors.lastname: Witcombe
authors.forename: Stephanie R
authors.initials: SR
authors.lastname: Yiallourou
authors.forename: Adrian M
authors.initials: AM
authors.lastname: Walker
authors.forename: Rosemary S C
authors.initials: RS
authors.lastname: Horne
mesh_terms: D000704:Analysis of Variance; D001794:Blood Pressure / Q000502:physiology*; D001795:Blood Pressure Determination; D002657:Child Development / Q000502:physiology*; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D017286:Polysomnography; D011237:Predictive Value of Tests; D012016:Reference Values; D012044:Regression Analysis; D018570:Risk Assessment; D012890:Sleep / Q000502:physiology; D013398:Sudden Infant Death / Q000453:epidemiology* / Q000209:etiology; D047929:Term Birth; D013997:Time Factors