Antifungal activity of caspofungin in combination with amphotericin B against Candida glabrata: comparison of disk diffusion, Etest, and time-kill methods.
The in vitro activities of caspofungin plus amphotericin B against 50 Candida glabrata isolates were evaluated by the time-kill, disk diffusion, and Etest methods. In vitro experiments showed a positive interaction. Even though each of these methods uses different conditions and endpoints, the results of the different methods frequently agreed.
Kiraz
Nuri
N
Department of Microbiology, University of Osmangazi, Eskişehir, Turkey. idag280@gmail.com
Dag
Ilknur
I
Yamac
Mustafa
M
Kiremitci
Abdurrahman
A
Kasifoglu
Nilgun
N
Akgun
Yurdanur
Y
D000666:Amphotericin B / Q000008:administration & dosage / Q000494:pharmacology*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology*; D041221:Candida glabrata / Q000187:drug effects*; D002177:Candidiasis / Q000382:microbiology; D000077336:Caspofungin; D004338:Drug Combinations; D004357:Drug Synergism; D054714:Echinocandins / Q000008:administration & dosage / Q000494:pharmacology*; D023381:Endpoint Determination; D006801:Humans; D055666:Lipopeptides; D008826:Microbial Sensitivity Tests; D013997:Time Factors
D000935:Antifungal Agents; D004338:Drug Combinations; D054714:Echinocandins; D055666:Lipopeptides; D000666:Amphotericin B; D000077336:Caspofungin