Cell adhesive hydrogels synthesised by copolymerisation of arg-protected Gly-Arg-Gly-Asp-Ser methacrylate monomers and enzymatic deprotection.
This work reports the synthesis of protected Gly-Arg-Gly-Asp-Ser functionalised hydrogels, which are deprotected (and activated for cell adhesion) by reaction with glutathione-S-transferase.
Perlin
Lynne
L
Department of Chemistry, University of Sheffield, Sheffield, South Yorkshire, UK S3 7HF.
MacNeil
Sheila
S
Rimmer
Stephen
S
D000595:Amino Acid Sequence; D002448:Cell Adhesion; D002478:Cells, Cultured; D000075202:Contraindications; D005347:Fibroblasts; D005982:Glutathione Transferase; D020100:Hydrogels / Q000138:chemical synthesis* / Q000737:chemistry; D008689:Methacrylates / Q000138:chemical synthesis* / Q000737:chemistry; D009842:Oligopeptides / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry
D020100:Hydrogels; D008689:Methacrylates; D009842:Oligopeptides; D010455:Peptides; D011108:Polymers; C049554:glycyl-arginyl-glycyl-aspartyl-serine; D005982:Glutathione Transferase