Two different types of ring-like enhancement on dynamic MR imaging in breast cancer: correlation with the histopathologic findings.
OBJECTIVE
To describe two different types of "ring-like enhancement" seen on dynamic magnetic resonance imaging (MRI) of breast cancer, and compare their histopathological features.


METHODS
A total of 326 breast carcinomas in 311 patients were evaluated regarding the existence and appearance of "ring-like enhancement" in comparison to other MR imaging and histopathological findings.


RESULTS
Early peripheral enhancement (EPE) was observed in 81 of 326 lesions (24.8%) and delayed rim enhancement (DRE) in 110 (33.7%). Spiculated mass, invasive ductal carcinoma with abundant stroma, central fibrosis/necrosis, and a higher degree of fat invasion correlated with EPE (P < 0.001). DRE correlated with lobulated or round mass with a smooth border, invasive ductal carcinoma with scanty stroma, higher degrees of inflammatory change and surrounding compressed tissue, and less fat invasion (P <0.001). EPE correlated with the ratio of the peripheral to central blood vessel density (P = 0.0036) and DRE with the ratio of the peritumoral to peripheral lymph vessel density (P = 0.0298).


CONCLUSIONS
The appearance of two different types of ring-like enhancement on dynamic MRI in breast cancers was affected by the morphologic features, various histological factors reflecting the growth pattern of the mass, and angiogenesis and lymphangiogenesis.
Kobayashi
Miki
M
Department of Radiology, Graduate School of Medical Sciences Kanazawa University, Kanazawa, Japan. mirai@rad.m.kanazawa-u.ac.jp
Kawashima
Hiroko
H
Matsui
Osamu
O
Zen
Yoh
Y
Suzuki
Masayuki
M
Inokuchi
Masafumi
M
Noguchi
Masakuni
M
Ohta
Tetsuo
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000473:pathology*; D016009:Chi-Square Distribution; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D012189:Retrospective Studies; D018709:Statistics, Nonparametric
D003287:Contrast Media; D019786:Gadolinium DTPA