title: Two new adjacent bis-tetrahydrofuran annonaceous acetogenins from seeds of Annona cornifolia.
abstract: Two new adjacent bis-THF annonaceous acetogenins, 9-hydroxyfolianin (1) and folianin B (2), together with two known acetogenins, asimicin (3) and bullatacin (4), significantly bioactives in brine shrimp lethality test, were isolated from seeds of Annona cornifolia A. St. Hil (Annonaceae). Their structures were elucidated by NMR and ESI-MS analysis, and relative configurations were established. The absolute configuration around the THF rings of 1 was defined by Mosher esters methodology and circular dichroism.
authors.affiliation: Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Luciana Alves
authors.initials: LA
authors.lastname: Rodrigues dos  Santos Lima
authors.forename: Lúcia Pinheiro
authors.initials: LP
authors.lastname: Santos Pimenta
authors.forename: Maria Amélia
authors.initials: MA
authors.lastname: Diamantino Boaventura
mesh_terms: D054378:Acetogenins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D031041:Annona / Q000737:chemistry*; D001156:Artemia / Q000187:drug effects; D005663:Furans / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D007928:Lethal Dose 50; D019906:Nuclear Magnetic Resonance, Biomolecular; D012639:Seeds / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: C539962:9-hydroxyfolianin; D054378:Acetogenins; D005663:Furans; C539963:folianin B; C061022:bullatacin