title: Association between the AGTR1 polymorphism +1166A>C and serum levels of high-sensitivity C-reactive protein.
abstract: Genetic factors have been shown to influence high-sensitivity C-reactive protein (hsCRP) levels, however, which genes that are involved in this process remains to be clarified. The renin-angiotensin system (RAS) is of importance for the regulation of inflammation, and blockade of angiotensin II type 1 receptors (AGTR1) influences hsCRP levels. These findings prompted us to investigate whether a polymorphism in the AGTR1 gene may influence hsCRP levels. Additionally, a polymorphism in the CRP gene that has previously been shown to influence hsCRP levels was genotyped. Serum levels of hsCRP were measured in 270 42-year-old women recruited from the population registry. Two single nucleotide polymorphisms were analysed: +1166A>C and +1444C>T of the AGTR1 and CRP gene, respectively. The A allele of the AGTR1 polymorphism +1166A>C was dose-dependently associated with higher hsCRP levels (p=0.014, adjusted for confounding factors and multiple comparisons). hsCRP levels were not significantly influenced by the CRP +1444C>T genotype; however, an interaction between the two studied polymorphisms with respect to hsCRP levels was observed (p=0.018). The significant association between the AGTR1 polymorphism and hsCRP levels, which appears to be independent of anthropometric and metabolic traits, is yet another indication of a direct influence of RAS on inflammation.
authors.affiliation: Department of Pharmacology, University of Gothenburg, SE-405 30 Gothenburg, Sweden. petra.suchankova@pharm.gu.se
authors.forename: Petra
authors.initials: P
authors.lastname: Suchankova
authors.forename: Susanne
authors.initials: S
authors.lastname: Henningsson
authors.forename: Marie
authors.initials: M
authors.lastname: Olsson
authors.forename: Fariba
authors.initials: F
authors.lastname: Baghaei
authors.forename: Roland
authors.initials: R
authors.lastname: Rosmond
authors.forename: Göran
authors.initials: G
authors.lastname: Holm
authors.forename: Elias
authors.initials: E
authors.lastname: Eriksson
authors.forename: Agneta
authors.initials: A
authors.lastname: Ekman
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000235:genetics / Q000378:metabolism*; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics*; D012084:Renin-Angiotensin System / Q000235:genetics
chemical_list: D044140:Receptor, Angiotensin, Type 1; D002097:C-Reactive Protein