Antidiabetic and antioxidant activities of major flavonoids of Cynanchum acutum L. (Asclepiadaceae) growing in Egypt.
Seven flavonoids were isolated from the butanol fraction of the methanolic extract of the aerial parts of Cynanchum acutum L. (Asclepiadaceae). All of which have been isolated for the first time from the genus Cynanchum. Their structures were established as quercetin 3-O-beta-galacturonopyranoside (1), quercetin 7-O-beta-glucopyranoside (2), tamarixtin 3-O-beta-galacturonopyranoside (3), kaempferol 3-O-beta-galacturonopyranoside (4), 8-hydroxyquercetin 3-O-beta-galactopyranoside (5), tamarixtin 3-O-alpha-rhamnopyranoside (6), and tamarixtin 7-O-alpha-arabinopyranoside (7) on the basis of their chromatographic properties, chemical and spectroscopic data. The major isolated flavonoids 1, 2 and 3 were found to exhibit significant antioxidant and antidiabetic activities (by measuring blood glucose and insulin levels). This is the first report about the antioxidant and antidiabetic activities of compounds 1-3.
Fawzy
Ghada A
GA
Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr-El-Aini St., 11562 Cairo, Egypt.
Abdallah
Hossam M
HM
Marzouk
Mohamed S A
MS
Soliman
Fathy M
FM
Sleem
Amany A
AA
D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D031105:Cynanchum / Q000737:chemistry* / Q000254:growth & development; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004534:Egypt; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D005978:Glutathione / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000627:therapeutic use; D007928:Lethal Dose 50; D008297:Male; D008687:Metformin / Q000627:therapeutic use; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats
D000975:Antioxidants; D001786:Blood Glucose; D005419:Flavonoids; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D008687:Metformin; D005978:Glutathione