title: A novel synthesis of highly substituted imidazo[1,5-a]pyrazine derivatives by 3-CR/2-CR sequence.
abstract: By combining a three-component reaction of 2, 3-diaminomaleonitrile, ketones and isocyanides with a subsequent reaction of 1,6-dihydropyrazine-2,3-dicarbonitrile derivatives obtained from isocyanide-based three-component reaction with various alkyl and aryl isocyanates or isothiocyanates can be assembled a new class of highly substituted imidazo[1,5-a]pyrazine derivatives.
authors.affiliation: Department of Chemistry, Shahid Beheshti University, P. O. Box 19396-4716, Tehran, Iran. a-shaabani@cc.sbu.ac.ir
authors.forename: Ahmad
authors.initials: A
authors.lastname: Shaabani
authors.forename: Ali
authors.initials: A
authors.lastname: Maleki
authors.forename: Hamid
authors.initials: H
authors.lastname: Mofakham
mesh_terms: D003486:Cyanides / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008956:Models, Chemical; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D011719:Pyrazines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C523085:1,6-dihydropyrazine-2,3-dicarbonitrile; D003486:Cyanides; D007093:Imidazoles; D007659:Ketones; D009570:Nitriles; D011719:Pyrazines; C022103:diaminomaleonitrile