title: Anthropometric factors in differentiated thyroid cancer in French Polynesia: a case-control study.
abstract: OBJECTIVE
  French Polynesia has one of the world's highest thyroid cancer incidence rates. A case-control study among native residents of French Polynesia included 219 cases of differentiated thyroid cancers diagnosed between 1979 and 2004 (195 women/24 men) matched with 359 population controls (315 women/44 men) on the date of birth.
  
  
  METHODS
  Anthropometric factors were analyzed by conditional logistic regression.
  
  
  RESULTS
  The risk of thyroid cancer for women in the highest quartile of body mass index (BMI) before diagnosis and at age 18 was 2.3-fold higher (95% CI, 1.1-4.7 p = 0.04) and 2.3-fold higher (95% CI, 1.2-4.4 p < 0.01), respectively, compared with the lowest. Women who were overweight (BMI = 25-29.9 kg/m2) or obese (BMI > or = 30 kg/m2) at age 18 and before diagnosis had an increased risk compared with those with a normal lifelong weight (OR = 6.2; 95% CI, 2.5-15.5 p < 0.01). Results for excess weight appeared in similar directions for men, although the number of cases was too small to provide reliable estimates. Height was positively associated with thyroid cancer among men and women.
  
  
  CONCLUSIONS
  This study shows the role of excess body weight, especially if the onset is during early adulthood, and elevated height in the risk of differentiated thyroid cancer in populations born in French Polynesia.
authors.affiliation: INSERM Unit 605, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France.
authors.forename: Pauline
authors.initials: P
authors.lastname: Brindel
authors.forename: Françoise
authors.initials: F
authors.lastname: Doyon
authors.forename: Frédérique
authors.initials: F
authors.lastname: Rachédi
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Boissin
authors.forename: Joseph
authors.initials: J
authors.lastname: Sebbag
authors.forename: Larrys
authors.initials: L
authors.lastname: Shan
authors.forename: Vaiana
authors.initials: V
authors.lastname: Chungue
authors.forename: Frédérique
authors.initials: F
authors.lastname: Bost-Bezeaud
authors.forename: Patrice
authors.initials: P
authors.lastname: Petitdidier
authors.forename: John
authors.initials: J
authors.lastname: Paoaafaite
authors.forename: Joseph
authors.initials: J
authors.lastname: Teuri
authors.forename: Florent
authors.initials: F
authors.lastname: de Vathaire
mesh_terms: D000293:Adolescent; D000328:Adult; D000886:Anthropometry; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011114:Polynesia / Q000453:epidemiology; D013964:Thyroid Neoplasms / Q000453:epidemiology*