Current update on established and novel biomarkers in salivary gland carcinoma pathology and the molecular pathways involved.
This review aims to take stock of the new information that has accumulated over the past decade on the molecular pathology of salivary gland cancer. Emphasis will be placed on established and novel immunohistochemical markers, the pathways involved, and on findings of prognostic importance as well as new therapeutic concepts. Whenever reasonable, analogies to tumors of better explored, histologically related glandular organs such as pancreas and breast are established.
Stenner
Markus
M
Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, University Hospital of Cologne, Cologne, Germany. markus.stenner@uk-koeln.de
Klussmann
J Peter
JP
D000328:Adult; D015415:Biomarkers; D002277:Carcinoma / Q000235:genetics* / Q000473:pathology*; D049109:Cell Proliferation; D016158:Genes, p53 / Q000235:genetics; D006801:Humans; D008875:Middle Aged; D009857:Oncogenes / Q000235:genetics*; D017354:Point Mutation / Q000235:genetics; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis; D012468:Salivary Gland Neoplasms / Q000235:genetics* / Q000473:pathology*; D015398:Signal Transduction
D015415:Biomarkers; D018809:Proliferating Cell Nuclear Antigen