Twisted tail: spinal epidural lipomatosis responding to chemotherapy in a patient with non-small-cell lung cancer.
Spinal epidural lipomatosis is a rare condition, described in corticoadrenal hyperactivity. It is most commonly seen in association with steroid administration and occasionally with Cushing's syndrome. This is the first case report of spinal epidural lipomatosis as presenting finding in a patient with non-small-cell lung carcinoma without any evidence of endogenous or exogenous hypercortisolism. The additional interesting feature is the paraneoplastic behaviour of this condition and even more interestingly its resolution following chemo-treatment of the primary cancer. Spinal epidural lipomatosis is a benign condition, which must be considered in the differential diagnosis of spinal cord compression in this category of patients. Its pathophysiology remains to be discovered in future.
Nasoodi
A
A
Department of Radiology, Royal Victoria Hospital, Belfast, UK. a.nasoodi@ntlworld.com
McAleese
J
J
Grey
A
A
Stranex
S
S
D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications* / Q000188:drug therapy*; D004824:Epidural Space / Q000473:pathology; D006801:Humans; D008068:Lipomatosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008175:Lung Neoplasms / Q000150:complications* / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D013122:Spinal Diseases / Q000150:complications* / Q000175:diagnosis
D000970:Antineoplastic Agents