title: Adolescent subgenual anterior cingulate activity is related to harm avoidance.
abstract: Recent adult studies suggest that the subgenual anterior cingulate cortex (sgACC) is involved in fundamental mental operations such as affective processing and inhibitory control. However, little is known about inhibition-associated sgACC function in adolescents, and there are no published data regarding whether personality characteristics are related to inhibition-associated sgACC brain activity in adolescents. This study examined the relationship between personality and inhibition-associated sgACC response in healthy adolescents. Seventeen adolescents of 13-17 years of age underwent functional magnetic resonance imaging while performing a parametric stop-signal task. Greater harm avoidance levels were significantly associated with increased inhibition-related sgACC activity. These results establish, for the first time, a link between personality and differential sgACC activation in adolescents.
authors.affiliation: Department of Psychiatry, University of California, San Diego, California 92123, USA. tyang@ucsd.edu
authors.forename: Tony T
authors.initials: TT
authors.lastname: Yang
authors.forename: Alan N
authors.initials: AN
authors.lastname: Simmons
authors.forename: Scott C
authors.initials: SC
authors.lastname: Matthews
authors.forename: Susan F
authors.initials: SF
authors.lastname: Tapert
authors.forename: Guido K
authors.initials: GK
authors.lastname: Frank
authors.forename: Amanda
authors.initials: A
authors.lastname: Bischoff-Grethe
authors.forename: Amy E
authors.initials: AE
authors.lastname: Lansing
authors.forename: Jing
authors.initials: J
authors.lastname: Wu
authors.forename: Martin P
authors.initials: MP
authors.lastname: Paulus
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior; D004644:Emotions / Q000502:physiology*; D007839:Functional Laterality / Q000502:physiology; D006179:Gyrus Cinguli / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007266:Inhibition, Psychological; D008279:Magnetic Resonance Imaging / Q000379:methods; D009483:Neuropsychological Tests; D010551:Personality / Q000502:physiology*; D010775:Photic Stimulation / Q000379:methods; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology