title: Distinguishing between parenchymal and anastomotic leakage at duct-to-mucosa pancreatic reconstruction in pancreaticoduodenectomy.
abstract: OBJECTIVE
  To distinguish anastomotic from parenchymal leakage at duct-to-mucosa reconstruction of the pancreatic remnant.
  
  
  METHODS
  We reviewed the charts of 68 pancreaticod-uodenectomies performed between 5/2000 and 12/2005 with end-to-side duct-to-mucosa pancreatojejunostomy (PJ). The results of pancreatography, as well as peripancreatic drain volumes, and amylase levels were analyzed.
  
  
  RESULTS
  Of 68 pancreatojejunostomies, 48 had no leak by pancreatography and had low-drain amylase (normal); eight had no pancreatographic leak but had elevated drain amylase (parenchymal leak); and 12 had pancreatographic leak and elevated drain amylase (anastomotic leak). Although drain volumes in the parenchymal leak group were significantly elevated at postoperative day (POD) 4, no difference was found at POD 7. Drain amylase level was not significantly different at POD 4. In contrast, at POD 7, the anastomotic-leak group had significantly elevated drain amylase level compared with normal and parenchymal-leak groups (14158 +/- 24083 IU/L vs 89 +/- 139 IU/L and 1707 +/- 1515 IU/L, respectively, P = 0.012).
  
  
  CONCLUSIONS
  For pancreatic remnant reconstruction after pancreaticoduodenectomy, a combination of pancreatogram and peripancreatic drain amylase levels can be used to distinguish between parenchymal and anastomotic leakage at pancreatic remnant reconstruction.
authors.affiliation: Division of Transplant Surgery, Department of Transplantation, Mayo Clinic, 4500 San Pablo Road, Jacksonville, Florida 32224, USA. nguyen.justin@mayo.edu
authors.forename: Justin-H
authors.initials: JH
authors.lastname: Nguyen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000681:Amylases / Q000378:metabolism; D000714:Anastomosis, Surgical / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D009092:Mucous Membrane / Q000378:metabolism / Q000601:surgery*; D010183:Pancreatic Ducts / Q000000981:diagnostic imaging / Q000378:metabolism / Q000601:surgery*; D016577:Pancreaticoduodenectomy / Q000379:methods*; D011184:Postoperative Period; D011859:Radiography; D012189:Retrospective Studies
chemical_list: D000681:Amylases