title: High-speed observation of cavitation bubble clouds near a tissue boundary in high-intensity focused ultrasound fields.
abstract: Cavitation bubble clouds generated near a tissue boundary by high-intensity focused ultrasound (HIFU) were studied using high-speed photography. In all, 171 image series were captured during the initial 100 ms of continuous HIFU exposure, which showed that cavitation bubble clouds at the tissue boundary organized into two structures - "cone-shape bubble cloud structure" recorded in 146 image series and "crown-shape bubble cloud structure" recorded in 18 image series. The remaining 7 image series showed the interchanging of these two structures. It was found that when cavitation bubbles first appeared at the tissue boundary, they developed to cone-shape bubble cloud. The cone-shape bubble cloud structure was characterized by a nearly fixed tip in front of the tissue boundary. When the cavitation bubbles initially appeared away from the tissue boundary they evolved into a crown-shape bubble cloud. Deformation of tissue boundary was shown in all the recorded image series.
authors.affiliation: The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, PR China.
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Li
authors.forename: Mingxi
authors.initials: M
authors.lastname: Wan
authors.forename: Supin
authors.initials: S
authors.lastname: Wang
mesh_terms: D005740:Gases / Q000032:analysis*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D066298:In Vitro Techniques; D007668:Kidney / Q000473:pathology* / Q000503:physiopathology* / Q000528:radiation effects; D007669:Kidney Calculi / Q000473:pathology* / Q000503:physiopathology* / Q000628:therapy; D008096:Lithotripsy / Q000379:methods*; D010781:Photography / Q000379:methods*
chemical_list: D005740:Gases