title: Accuracy and definitive interpretation of preoperative technetium 99m sestamibi imaging based on the discipline of the reader.
abstract: BACKGROUND
  Technetium 99m sestamibi scans have become a principal means of localizing parathyroid adenomas. Its accuracy and reliability has allowed for the proliferation of minimal access parathyroidectomy. Localizing interpretation of these scans often drives referral of hyperparathyroid patients for surgery. Interpretation of these scans may differ between nuclear medicine physicians and surgeons.
  
  
  METHODS
  We reviewed patients (N = 65) with digital images from an academic medical center with the diagnosis of primary hyperparathyroidism. We assessed the willingness to define an adenoma's location, the interrater reliability, and the accuracy of technetium (Tc-99m) sestamibi read by a surgeon and a nuclear medicine physician.
  
  
  RESULTS
  There was poor correlation between both readers for assessment of quality of images (k = 0.54, 0.07) but very good correlation for adenoma location (k = 0.81).
  
  
  CONCLUSIONS
  Both readers had good accuracy in predicting the location of the parathyroid adenoma. The surgeon was more likely to call a scan positive.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Oregon Health and Sciences University, Portland, OR, USA.
authors.forename: Ayesha N
authors.initials: AN
authors.lastname: Khalid
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Hollenbeak
authors.forename: Bruce W
authors.initials: BW
authors.lastname: Higginbotham
authors.forename: Brendan C
authors.initials: BC
authors.lastname: Stack
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging* / Q000601:surgery; D013502:General Surgery; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000209:etiology; D009683:Nuclear Medicine; D015588:Observer Variation; D010282:Parathyroid Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D016105:Parathyroidectomy; D011300:Preoperative Care; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012189:Retrospective Studies; D017256:Technetium Tc 99m Sestamibi
chemical_list: D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi