An armed-disarmed approach for blocking aglycon transfer of thioglycosides.
Thioglycosides are used frequently as glycosyl donors and as mimetics of O-glycosides. While being very useful, thioglycosides are prone to a detrimental side reaction referred to as aglycon transfer. In this paper, it is shown that aglycon transfer can be blocked by matching thioglycoside-containing acceptors with more armed glycosyl donors.
Li
Zhitao
Z
Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702 USA.
Gildersleeve
Jeffrey C
JC