Highly efficient copper-catalyzed cascade synthesis of quinazoline and quinazolinone derivatives.
We have developed a general and highly efficient copper-catalyzed method for synthesis of quinazoline and quinazolinone derivatives, the target products were obtained in good to excellent yields via cascade reactions of amidine hydrochlorides with substituted 2-halobenzaldehydes, 2-halophenylketones, or methyl 2-halobenzoates, and the method is of simple, economical and practical advantages.
Huang
Cheng
C
Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084, PR China.
Fu
Yuan
Y
Fu
Hua
H
Jiang
Yuyang
Y
Zhao
Yufen
Y
D000578:Amidines / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry
D000578:Amidines; D011799:Quinazolines; D003300:Copper; C023731:acetamidine