Novel polymeric coatings with the potential to control in-stent restenosis--an in vitro study.
Restenosis following percutaneous coronary intervention (PCI) is a considerable problem in long-term performance of cardiovascular stents, with a functional endothelial cell monolayer being important in its prevention. This study evaluates the influence of polymer coatings on human aortic endothelial cells (HAEC) and coronary artery smooth muscle cells (HCASMC) in vitro, in terms of morphology, cell number, and phenotype. It was demonstrated that the polymer coatings can be tailored to enhance adhesion and growth of HAECs whilst suppressing that of HCASMCs. It is concluded that one of the polymer coatings (BTL 01015) shows potential as a stent coating to enhance re-endothelialization.
Nickson
C M
CM
Clinical Engineering, School of Clinical Sciences, University of Liverpool Duncan Building, Daulby Street, Liverpool L693GA. c.m.nickson@liv.ac.uk
Doherty
P J
PJ
Williams
R L
RL
D002448:Cell Adhesion; D002452:Cell Count; D002478:Cells, Cultured; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D023903:Coronary Restenosis / Q000517:prevention & control*; D054855:Drug-Eluting Stents; D042783:Endothelial Cells / Q000166:cytology; D006801:Humans; D066298:In Vitro Techniques; D008422:Materials Testing; D032383:Myocytes, Cardiac / Q000166:cytology; D010641:Phenotype; D011108:Polymers / Q000737:chemistry*
D020099:Coated Materials, Biocompatible; D011108:Polymers