title: Protective antioxidant effect of Centella asiatica bioflavonoids on lead acetate induced neurotoxicity.
abstract: Lead (Pb) is a neurotoxic heavy metal and children in the developmental stage are particularly susceptible to toxic effects of lead exposure. The brain is the key organ involved in interpreting and responding to potential stressors. Epidemiological investigations have established the relationship between chronic lead exposure and cognitive impairments in young children. Excessive production of radical species plays an important role in neuronal pathology resulting from excitotoxic insults, therefore one plausible neuroprotective mechanism of bioflavonoids is partly relevant to their metal chelating and antioxidant properties. Centella asiatica (CA) is a tropical medicinal plant enriched with bioflavonoids and triterpenes and selenium, reported to rejuvenate the cells and promote physical and mental health. Bioflavonoids are claimed to be exert antimutagenic, neurotrophic and xenobiotics ameliorating and membrane molecular stabilizing effects. The objective of the present work is to study the protective antioxidant effect of pretreatment of CA extract (CAE) on lead acetate induced changes in oxidative biomarkers in the central nervous system (CNS) of mice.
authors.affiliation: Department of Human Biology, International Medical University, Kuala Lumpur, Malaysia.
authors.forename: K
authors.initials: K
authors.lastname: Ponnusamy
authors.forename: M
authors.initials: M
authors.lastname: Mohan
authors.forename: H S
authors.initials: HS
authors.lastname: Nagaraja
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D015415:Biomarkers; D001921:Brain / Q000187:drug effects*; D028041:Centella; D002490:Central Nervous System / Q000187:drug effects; D005419:Flavonoids / Q000494:pharmacology*; D020263:Lead Poisoning, Nervous System / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control; D051379:Mice; D023421:Models, Animal; D018696:Neuroprotective Agents / Q000627:therapeutic use; D009942:Organometallic Compounds / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects; D010865:Pilot Projects; D010936:Plant Extracts; D014315:Triterpenes / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; C526146:Centella asiatica extract; D005419:Flavonoids; D018696:Neuroprotective Agents; D009942:Organometallic Compounds; D010936:Plant Extracts; D014315:Triterpenes; C008261:lead acetate