title: Use of intralesional oestradiol concentration to identify a functional pulmonary metastasis of canine sertoli cell tumour.
abstract: A seven-year-old, 31 kg male neutered Labrador was investigated for signs of feminisation syndrome and prostatic disease four years after castration and removal of a testicular sertoli cell tumour (SCT). Investigations revealed an elevated serum oestradiol-17beta concentration, a pulmonary mass containing fluid high in oestradiol-17beta and cystic changes in the prostate gland. The pulmonary mass was surgically excised and histologically confirmed to be a SCT metastasis. To the authors' knowledge, this is the first reported case of a proven functional extranodal SCT metastasis and the first to be diagnosed by oestradiol-17beta measurement of intralesional fluid.
authors.affiliation: University of Glasgow, 464 Bearsden Road, Bearsden, Glasgow G611QH, UK.
authors.forename: D
authors.initials: D
authors.lastname: Gopinath
authors.forename: D
authors.initials: D
authors.lastname: Draffan
authors.forename: A W
authors.initials: AW
authors.lastname: Philbey
authors.forename: R
authors.initials: R
authors.lastname: Bell
mesh_terms: D000818:Animals; D003456:Cryptorchidism / Q000662:veterinary; D003560:Cysts / Q000473:pathology / Q000662:veterinary; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D004285:Dogs; D004958:Estradiol / Q000032:analysis*; D005262:Feminization / Q000209:etiology / Q000662:veterinary; D008175:Lung Neoplasms / Q000556:secondary / Q000601:surgery / Q000662:veterinary*; D008297:Male; D011467:Prostate / Q000000981:diagnostic imaging; D011863:Radioimmunoassay / Q000662:veterinary; D012707:Sertoli Cell Tumor / Q000150:complications / Q000175:diagnosis / Q000556:secondary / Q000662:veterinary*; D013736:Testicular Neoplasms / Q000150:complications / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D004958:Estradiol