title: Polymer embedded nanocrystalline titania sorbent for 99Mo-99mTc generator.
abstract: A new sorbent material, polymer embedded nano crystalline titania (Titanium Polymer-TiP) has been developed, from titanium (IV) chloride and isopropyl alcohol, for the adsorption of 99Mo, which is a precursor to 99mTc, a workhorse in radio-pharmaceuticals. The infrared absorption spectra of the TiP showed peaks corresponding to Ti-O groups. X-ray diffraction pattern of the adsorbent corresponded to rutile TiO2. The surface area of this polymer was 30 m2/g with an average pore size of 40 nm. The average crystallite size of TiO2, embedded in polymer, was found to be 5 nm. TEM micrograph of the adsorbent revealed the network of polymer with dispersed titania phase. Potential of this adsorbent for the preparation of 99Mo-99mTc generator has been explored. 99Mo could be adsorbed on to the adsorbent column containing TiP at pH 1 from which 99mTC could be eluted with normal (0.9%) saline solution with an elution yield of approximately 80%. The quality of the 99mTcO4 obtained was in accordance with the international specifications applicable for radiopharmaceutical use. A process demonstration run was carried out with 1.1 GBq (30 mCi) 99Mo activity level making use of the above adsorbent and consistent results were obtained over a period of one week, which is generally the shelf life of 99MO-99mTC generator.
authors.affiliation: Radiopharmaceuticals Division, 2 Chemistry Division, Bhabha Atomic Research Centre, Mumbai 400085, India.
authors.forename: Rubel
authors.initials: R
authors.lastname: Chakravarty
authors.forename: Rakesh
authors.initials: R
authors.lastname: Shukla
authors.forename: Shyamla
authors.initials: S
authors.lastname: Gandhi
authors.forename: Ramu
authors.initials: R
authors.lastname: Ram
authors.forename: Ashutosh
authors.initials: A
authors.lastname: Dash
authors.forename: Meera
authors.initials: M
authors.lastname: Venkatesh
authors.forename: A K
authors.initials: AK
authors.lastname: Tyagi
mesh_terms: D000327:Adsorption; D003460:Crystallization; D008982:Molybdenum / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D011108:Polymers / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry; D013667:Technetium / Q000737:chemistry*; D013997:Time Factors; D014025:Titanium / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D011108:Polymers; D019275:Radiopharmaceuticals; D013667:Technetium; D008982:Molybdenum; D014025:Titanium