Synthesis and antibacterial properties of 1,2,3-aryl-1,2,3,4-tetrahydropyrimido[4,5-d]pyrimidine derivatives.
The 1,2,3-aryl-1,2,3,4-tetrahydropyrimido[4,5-d]pyrimidine derivatives have been synthesized and evaluated as antibacterial agents. The X-ray crystallography study has been undertaken to confirm structure of 2-(4-chlorophenyl)-,1 3-di-(4-methoxyphenyl)-5-methyl-7-phenyl- ,2,3,4-tetrahydropyrimido[4,5-d]pyrimidine. The antibacterial properties were tested using six selected strains by comparing changes of chemical structures with growth of biological activity. Most of the synthesized compounds exhibited antibacterial activity, and their activity can be connected with the cyclization to the pyrimido[4,5-d]pyrimidine system and nature of the substituent attached to phenyl rings.
Cieplik
Jerzy
J
Department of Organic Chemistry, Medical Academy, 9 Grodzka Street, 50-137 Wrocław, Poland. jerzy@chorg.am.wroc.pl
Raginia
Małgorzata
M
Pluta
Janusz
J
Gubrynowicz
Olaf
O
Bryndal
Iwona
I
Lis
Tadeusz
T
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D011743:Pyrimidines