title: Monoclonality of composite large cell neuroendocrine carcinoma and mucinous epithelial tumor of the ovary: a case study.
abstract: A rare case of mixed carcinoma of the ovary is reported, composed of a large cell neuroendocrine carcinoma and a mucinous borderline endocervical tumor. The large cell neuroendocrine carcinoma was composed of solid nests, sheets, and trabeculae of medium to large-sized cells, and was positive for synaptophysin. The mucinous epithelial tumor varied in appearance from a borderline to an intraepithelial carcinoma, and showed sparsely scattered immunoreactivity for chromogranin-A. Using an X-chromosome clonality assay, these 2 components showed patterns of monoclonality. These results suggest that the large cell neuroendocrine carcinoma may have arisen from the mucinous epithelial tumor.
authors.affiliation: Department of Clinical Laboratory Medicine, Wakayama Medical University, Wakayama City, Wakayama, Japan.
authors.forename: Hironao
authors.initials: H
authors.lastname: Yasuoka
authors.forename: Masahiko
authors.initials: M
authors.lastname: Tsujimoto
authors.forename: Shigeki
authors.initials: S
authors.lastname: Fujita
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kunishige
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Nishio
authors.forename: Rieko
authors.initials: R
authors.lastname: Kodama
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Oishi
authors.forename: Tokio
authors.initials: T
authors.lastname: Sanke
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Nakamura
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000235:genetics / Q000473:pathology*; D000328:Adult; D018287:Carcinoma, Large Cell / Q000235:genetics / Q000473:pathology*; D018278:Carcinoma, Neuroendocrine / Q000235:genetics / Q000473:pathology*; D002999:Clone Cells; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000235:genetics / Q000473:pathology*; D016133:Polymerase Chain Reaction; D011944:Receptors, Androgen / Q000235:genetics
chemical_list: D011944:Receptors, Androgen