title: The prevalence and phenomenology of repetitive behavior in genetic syndromes.
abstract: We investigated the prevalence and phenomenology of repetitive behavior in genetic syndromes to detail profiles of behavior. The Repetitive Behaviour Questionnaire (RBQ) provides fine-grained identification of repetitive behaviors. The RBQ was employed to examine repetitive behavior in Angelman (N = 104), Cornelia de Lange (N = 101), Cri-du-Chat (N = 58), Fragile X (N = 191), Prader-Willi (N = 189), Lowe (N = 56) and Smith-Magenis (N = 42) syndromes and individuals with intellectual disability of heterogeneous aetiology (N = 56). Repetitive behavior was variable across syndromes. Fragile X syndrome scored highly on all subscales. Angelman syndrome demonstrated a significantly lowered probability for most behaviors. Prader-Willi, Cri-du-Chat and Smith-Magenis syndrome evidenced unique profiles of repetitive behavior. There is extreme heterogeneity of repetitive behavior across genetic syndromes, highlighting syndrome specific profiles.
authors.affiliation: Centre for Neurodevelopmental Disorders, School of Psychology, University of Birmingham, Birmingham, UK.
authors.forename: Joanna
authors.initials: J
authors.lastname: Moss
authors.forename: Chris
authors.initials: C
authors.lastname: Oliver
authors.forename: Kate
authors.initials: K
authors.lastname: Arron
authors.forename: Cheryl
authors.initials: C
authors.lastname: Burbidge
authors.forename: Katy
authors.initials: K
authors.lastname: Berg
mesh_terms: D000293:Adolescent; D000328:Adult; D017204:Angelman Syndrome / Q000453:epidemiology / Q000523:psychology; D002648:Child; D002675:Child, Preschool; D003410:Cri-du-Chat Syndrome / Q000453:epidemiology / Q000523:psychology; D003635:De Lange Syndrome / Q000453:epidemiology / Q000523:psychology; D005260:Female; D005600:Fragile X Syndrome / Q000453:epidemiology / Q000523:psychology; D006801:Humans; D008607:Intellectual Disability / Q000453:epidemiology* / Q000235:genetics / Q000523:psychology*; D008131:London; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011218:Prader-Willi Syndrome / Q000453:epidemiology / Q000523:psychology; D015995:Prevalence; D013239:Stereotyped Behavior; D011795:Surveys and Questionnaires; D013577:Syndrome; D055815:Young Adult