title: Cobb syndrome: a case report and systematic review of the literature.
abstract: We report on a case of Cobb syndrome, a rare metameric disorder, characterized by a vascular abnormality of the spinal cord, with an associated vascular skin lesion of the same metamere, in an 8-year-old girl presenting with leg weakness. Magnetic resonance imaging revealed a spinal arteriovenous malformation at the level of T(10)-L(5). This finding, together with a large, pigmented nevus at this level, is diagnostic for Cobb syndrome. A systematic review of the literature on Cobb syndrome, with a focus on treatment and outcomes, is presented. Current treatment options include combinations of embolization, neurosurgical intervention, corticosteroid therapy, and radiotherapy.
authors.affiliation: Department of Paediatrics, Monash Medical Centre, Monash University, Melbourne, Victoria, Australia.
authors.forename: Marissa Tubridy
authors.initials: MT
authors.lastname: Clark
authors.forename: Emma L
authors.initials: EL
authors.lastname: Brooks
authors.forename: Winston
authors.initials: W
authors.lastname: Chong
authors.forename: Chris
authors.initials: C
authors.lastname: Pappas
authors.forename: Michael
authors.initials: M
authors.lastname: Fahey
mesh_terms: D020785:Central Nervous System Vascular Malformations / Q000150:complications*; D002648:Child; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D012871:Skin Diseases / Q000150:complications*; D013122:Spinal Diseases / Q000150:complications*