[Obesity and polycystic ovary syndrome: reproductive issues].
Polycystic ovary syndrome (PCOS) is responsible for most cases of anovulatory infertility. Hyperandrogenism, follicle excess and follicular arrest play a fundamental role that is amplified by obsesity and particularly by visceral fat excess. Hyperinsulinism is the main culprit in this aggravation. The impact of obseity on female fertility also involves extra-ovarian phenomena, and particularly negative effects on the endometrium that can lead to implantation failure and miscarriage
Dewailly
Didier
D
Service de Gynécologie endocrinienne et Médecine de la Reproduction, Hôpital Jeanne de Flandre, Centre Hospitalier de Lille, 59037.
D000858:Anovulation / Q000209:etiology; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology*; D009765:Obesity / Q000150:complications* / Q000503:physiopathology; D010060:Ovulation; D011085:Polycystic Ovary Syndrome / Q000209:etiology* / Q000503:physiopathology