[Oxidative damages in rats induced by the diet from Yanting region with high prevalence of esophageal cancers].
OBJECTIVE
To test the effect of the diet from Yanting region, a region with high prevalence of esophagus cancers, on oxidative damages in rats.


METHODS
Thirty male SD rats were randomly divided into three experimental groups and fed with standard diets, Yanting diets, and Chengdu diets (a region with low prevalence of esophageal cancers), respectively. One month later, the rats were killed. The livers and esophagus of those rats were taken immediately and were weighted, homogenated, and centrifuged at a low temperature to dissociate the supernatants. The contents of NO and MDA and the activities of NOS, SOD, CAT, and GSH-Px in the supernatants were measured.


RESULTS
The rats fed with Chengdu diets showed no differences with those fed with standard diets. But the rats fed with Yanting diets had significantly higher NO, MDA and NOS, and lower activities of SOD, CAT, and GSH-Px in the livers than those fed with Chengdu diets. The rats fed with Yanting diets also had higher MHA and lower CAT in the esophagus than those fed with Chengdu diets.


CONCLUSIONS
Yanting diets stimulate the oxidative damages of the livers and esophagus in rats.
Zhu
Wen-yi
WY
Department of Nutrition and Food Hygiene, West China School of Public Health, Sichuan University, Chengdu, China.
Jiang
Yan
Y
Huang
Cheng-yu
CY
Li
Ming
M
D000818:Animals; D002681:China / Q000453:epidemiology; D004032:Diet; D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D018384:Oxidative Stress; D015995:Prevalence; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism*
D009569:Nitric Oxide; D013482:Superoxide Dismutase