title: A range of cancers is associated with the rs6983267 marker on chromosome 8.
abstract: Several genome-wide searches for common cancers have lead to the identification of a small number of loci that harbor low-risk cancer susceptibility markers. One marker, rs6983267 on chromosome 8q24, has been linked to both colon and prostate cancer, and is therefore a good candidate for a multicancer susceptibility marker. To determine the range of cancer sites associated with rs6983267, we genotyped 7,665 cases of cancer, representing 11 common cancer sites, and 1,910 controls. A significant odds ratio (OR) was observed for prostate cancer for carriers of genotype GG [OR, 1.77; 95% confidence interval (CI), 1.47-2.13]. The homozygote OR was higher for tumors with Gleason score 8 to 10 (OR, 1.94; 95% CI, 1.18-3.20) than for tumors with Gleason score 7 and below (OR, 1.65; 95% CI, 1.31-2.08). Significantly elevated (homozygote) ORs were observed for 4 other cancer sites, including colon (OR, 1.36; 95% CI, 1.08-1.72), kidney (OR, 1.52; 95% CI, 1.12-2.05), thyroid (OR, 1.37; 95% CI, 1.02-1.82), and larynx (OR, 1.39; 95% CI, 1.02-1.90). Information was available on family histories of cancer for eight sites. For six of the eight sites (prostate, breast, bladder, larynx, lung, and kidney), the homozygote ORs were higher for cases with a positive family history (at least one first-degree with any cancer) than for cases with unaffected first-degree relatives. Our results suggest that the range of cancers associated with the rs6983267 marker might be larger than previously thought.
authors.affiliation: International Hereditary Cancer Center, Department of Genetics and Pathology and Clinic of Urology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Dominika
authors.initials: D
authors.lastname: Wokolorczyk
authors.forename: Bartlomiej
authors.initials: B
authors.lastname: Gliniewicz
authors.forename: Andrzej
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authors.lastname: Sikorski
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Zlowocka
authors.forename: Bartlomiej
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authors.lastname: Masojc
authors.forename: Tadeusz
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authors.lastname: Debniak
authors.forename: Joanna
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authors.lastname: Matyjasik
authors.forename: Marek
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authors.lastname: Mierzejewski
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Medrek
authors.forename: Dorota
authors.initials: D
authors.lastname: Oszutowska
authors.forename: Janina
authors.initials: J
authors.lastname: Suchy
authors.forename: Jacek
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authors.lastname: Gronwald
authors.forename: Urszula
authors.initials: U
authors.lastname: Teodorczyk
authors.forename: Tomasz
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authors.lastname: Huzarski
authors.forename: Tomasz
authors.initials: T
authors.lastname: Byrski
authors.forename: Anna
authors.initials: A
authors.lastname: Jakubowska
authors.forename: Bohdan
authors.initials: B
authors.lastname: Górski
authors.forename: Thierry
authors.initials: T
authors.lastname: van de Wetering
authors.forename: Swietlana
authors.initials: S
authors.lastname: Walczak
authors.forename: Steven A
authors.initials: SA
authors.lastname: Narod
authors.forename: Jan
authors.initials: J
authors.lastname: Lubinski
authors.forename: Cezary
authors.initials: C
authors.lastname: Cybulski
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002898:Chromosomes, Human, Pair 8; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D005819:Genetic Markers