Antidiabetic effect through islet cell protection in streptozotocin diabetes: a preliminary assessment of two thiazolidin-4-ones in Swiss albino mice.
This study was undertaken on the basis of several reports in the literature that pancreatic beta cells are capable of replication/regeneration and also being afforded protection against damage induced by streptozotocin. Nicotinamide was reported to give protection against streptozotocin-induced damage in rats. In the present study, two thiazolidine-4-ones with nicotinamide substitution were administered to Swiss albino mice with streptozotocin diabetes for 15 days. Concurrently, one group received nicotinic acid. Both the test compounds reversed the hyperglycaemia diabetic mice. Damage to pancreatic islets was also reduced in these groups compared to diabetic control and nicotinic acid treated groups. Since these compounds have been earlier found have antioxidant activity, one of the possible mechanisms of action could be by reducing oxidative stress in pancreas. Further, possibly by releasing nicotinamide in vivo, the molecules could have contributed to the NAD pool in pancreas and afforded protection. It is concluded that the test compounds have potential to be developed for multiple beneficial action in conditions like metabolic syndrome.
Kishore
Anoop
A
Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Madhava Nagar, Manipal 576104, India.
Nampurath
Gopalan Kutty
GK
Mathew
Suma P
SP
Zachariah
Robby T
RT
Potu
Bhagath Kumar
BK
Rao
Muddanna S
MS
Valiathan
Manna
M
Chamallamudi
Mallikarjuna Rao
MR
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000473:pathology*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007515:Islets of Langerhans / Q000187:drug effects*; D008297:Male; D051379:Mice; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000494:pharmacology; D013311:Streptozocin
D001786:Blood Glucose; D007004:Hypoglycemic Agents; C524550:N-(2-(3,5-di-tert-butyl-4-hydroxyphenyl)-4-oxo-thiazolidin-3-yl)-nicotinamide; C528863:N-(2-(4-methoxyphenyl)-4-oxothiazolidin-3-yl)nicotinamide; D009536:Niacinamide; D013311:Streptozocin