Scalarane-based metabolites isolated from the antimitotic extract of the marine sponge Hyrtios erectus.
Two novel sesterterpenes, 1 and 3, containing a scalarane-based framework, have been isolated from the sponge Hyrtios erectus collected in Papua New Guinea. Their structures and relative stereochemistry have been elucidated by analysis of their spectroscopic data.
Díaz-Marrero
Ana R
AR
Department of Chemistry, University of British Columbia, Vancouver, Canada.
Matainaho
Teatulohi
T
van Soest
Rob
R
Roberge
Michel
M
Andersen
Raymond J
RJ
D000818:Animals; D050256:Antimitotic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005260:Female; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010219:Papua New Guinea; D011161:Porifera / Q000737:chemistry*; D054830:Sesterterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013237:Stereoisomerism
C476834:12-O-deacetyl-12-epi-scalarin; C533511:12-O-deacetyl-19-methoxy-12-epi-scalarin; C533510:12beta,16beta-diacetoxyscalarolbutenolide; D050256:Antimitotic Agents; D054830:Sesterterpenes