One-pot synthesis of substituted furans using Cu(OTf)(2)-catalyzed propargylation/cycloisomerization tandem reaction.
A convenient one-pot propargylation/cycloisomerization tandem process has been developed for the synthesis of substituted furans derivatives from 1,3-dicarbonyl compounds and enoxysilanes with propargylic alcohols or acetates using copper(II) triflate as a bifunctional catalyst. This method provides a flexible and rapid route to substituted furans.
Pan
Ying-ming
YM
Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, P. R. China.
Zhao
Su-yan
SY
Ji
Wen-hua
WH
Zhan
Zhuang-ping
ZP
D000480:Alkynes / Q000737:chemistry; D002384:Catalysis; D003300:Copper; D003500:Cyclization; D005663:Furans / Q000138:chemical synthesis*; D007536:Isomerism; D008722:Methods
D000480:Alkynes; D005663:Furans; D003300:Copper