99mTc-HYNIC octreotide in neuroblastoma.
Disease status assessment of neuroblastoma patients requires computed tomography (or magnetic resonance imaging), bone scan, metaiodobenzylguanidine (MIBG) scan, bone marrow tests, and urine catecholamine measurements. There is no clinical experience concerning the evaluation of these patients by means of technetium-99m (99mTc)-somatostatin analog scintigraphy. Furthermore, these radiopharmaceuticals are promising imaging agents owing to their lower cost, availability, dosimetry, and ease of preparation. An 8-year-old boy already diagnosed with stage-IV neuroblastoma received chemotherapy. In the follow-up, after obtaining the parents' informed consent, iodin 131 (131I)-MIBG and 99mTc-6-hydrazinopyridine-3-carboxylic acid (HYNIC)-octreotide scans were done on separate days to evaluate tumor extension. Even as the 131I-IBG scan showed mild diffuse uptake in the projection of both lung hili, the 99mTc-HYNIC-octreotide scan showed multiple axial and appendicular bone uptakes and paravertebral, abdominal, mediastinal, and supraclavicular ganglionar uptakes. The 99mTc-HYNIC-octreotide showed much more lesion extension than the 131I-MIBG. Therefore, 99mTc-HYNIC-octreotide may be a promising radiopharmaceutical for the evaluation of neuroblastoma patients. This finding justifies the preliminary evaluation of this tracer in the context of a clinical trial.
Gambini
Juan P
JP
Nuclear Medicine Center, Clinical Hospital, University of Uruguay, Av. Italia s/n, C.P. 11600, Montevideo, Uruguay.
López Lerena
Juan J
JJ
Quagliata
Adriana
A
Hermida
Juan C
JC
Heuguerot
Carlos
C
Alonso
Omar
O
D019797:3-Iodobenzylguanidine; D000310:Adrenal Gland Neoplasms / Q000000981:diagnostic imaging*; D002648:Child; D006801:Humans; D008297:Male; D009447:Neuroblastoma / Q000000981:diagnostic imaging*; D015282:Octreotide / Q000031:analogs & derivatives*; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals
D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C410263:technetium Tc 99m hydrazinonicotinyl-Tyr(3)-octreotide; D019797:3-Iodobenzylguanidine; D015282:Octreotide