Microbial degradation of pharmaceuticals in estuarine and coastal seawater.
Microbial degradation rates were measured for 19 pharmaceuticals in estuarine and coastal surface water samples. Antipyrine, carbamazepine, cotinine, sulfamethoxazole, and trimethoprim were the most refractory (half-lives, t(1/2)=35 to >100 days), making them excellent candidates for wastewater tracers. Nicotine, acetaminophen, and fluoxetine were labile across all treatments (t(1/2)=0.68-11 days). Caffeine, diltiazem, and nifedipine were also and relatively labile in all but one of the treatments (t(1/2)=3.5-13 days). Microbial degradation of caffeine was further confirmed by production (14)CO(2). The fastest decay of non-refractory compounds was always observed in more sewage-affected Jamaica Bay waters. Degradation rates for the majority of these pharmaceuticals are much slower than reported rates for small biomolecules, such as glucose and amino acids. Batch sorption experiments indicate that removal of these soluble pharmaceuticals from the water column to sediments is a relatively insignificant removal process in these receiving waters.
Benotti
Mark J
MJ
Marine Sciences Research Center, Stony Brook University, Stony Brook, NY 11794-5000, USA.
Brownawell
Bruce J
BJ
D000042:Absorption; D000983:Antipyrine / Q000032:analysis; D001419:Bacteria / Q000378:metabolism*; D001673:Biodegradation, Environmental; D002110:Caffeine / Q000032:analysis; D002220:Carbamazepine / Q000032:analysis; D003367:Cotinine / Q000032:analysis; D004110:Diltiazem / Q000032:analysis; D004463:Ecology / Q000379:methods; D052244:Endocrine Disruptors / Q000378:metabolism; D006207:Half-Life; D009518:New York; D009543:Nifedipine / Q000032:analysis; D004364:Pharmaceutical Preparations / Q000032:analysis / Q000378:metabolism*; D012623:Seawater; D012995:Solubility; D013420:Sulfamethoxazole / Q000032:analysis; D014295:Trimethoprim; D014865:Waste Disposal, Fluid; D014871:Water Microbiology; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000378:metabolism*
D052244:Endocrine Disruptors; D004364:Pharmaceutical Preparations; D014874:Water Pollutants, Chemical; D002220:Carbamazepine; D002110:Caffeine; D014295:Trimethoprim; D004110:Diltiazem; D009543:Nifedipine; D013420:Sulfamethoxazole; D003367:Cotinine; D000983:Antipyrine