Plasma lipids and inflammation in active inflammatory bowel diseases.
BACKGROUND
Ulcerative colitis (UC) and Crohn's disease (CD) can cause metabolic and inflammatory alterations.


OBJECTIVE
To evaluate the relationships between inflammatory parameters, plasma lipids and phospholipid fatty acid (FA) composition in patients with active UC and CD.


METHODS
Diet, the Harvey-Bradshaw Activity Index (HBAI), inflammatory parameters, lipoproteins and FA composition were assessed in 60 CD and 34 UC.


RESULTS
No differences in clinical parameters were observed in the two groups. Total cholesterol correlated inversely with the number of bowel movements in both groups and directly with BMI in UC. Arachidonic acid correlated inversely with HBAI in UC and total and HDL cholesterol were inversely related to C-reactive protein (CRP) in CD while HDL correlated with CRP in UC. Docosapentaenoic acid was the only polyunsaturated n-3 FA that was correlated to CRP in both groups. Total cholesterol was independently associated in the multiple regression analysis with the number of bowel movements and systemic inflammation.


CONCLUSIONS
Total and LDL cholesterol were lower in the active UC and CD than in the healthy subjects and were correlated with the systemic inflammatory status. Phospholipid FA composition was correlated to the systemic inflammatory status, but was unrelated to dietary intake and intestinal disease activity.
Romanato
G
G
CNR-Institute of Neurosciences-Aging Section, Padova, Italy. giovanna.romanato@unipd.it
Scarpa
M
M
Angriman
I
I
Faggian
D
D
Ruffolo
C
C
Marin
R
R
Zambon
S
S
Basato
S
S
Zanoni
S
S
Filosa
T
T
Pilon
F
F
Manzato
E
E
D000293:Adolescent; D000328:Adult; D015415:Biomarkers; D001774:Blood Chemical Analysis; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000378:metabolism*; D008078:Cholesterol, LDL / Q000378:metabolism*; D003093:Colitis, Ulcerative / Q000378:metabolism*; D003424:Crohn Disease / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism*; D015930:Diet Records; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D055815:Young Adult
D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D016207:Cytokines