title: Two different types of ring-like enhancement on dynamic MR imaging in breast cancer: correlation with the histopathologic findings.
abstract: OBJECTIVE
  To describe two different types of "ring-like enhancement" seen on dynamic magnetic resonance imaging (MRI) of breast cancer, and compare their histopathological features.
  
  
  METHODS
  A total of 326 breast carcinomas in 311 patients were evaluated regarding the existence and appearance of "ring-like enhancement" in comparison to other MR imaging and histopathological findings.
  
  
  RESULTS
  Early peripheral enhancement (EPE) was observed in 81 of 326 lesions (24.8%) and delayed rim enhancement (DRE) in 110 (33.7%). Spiculated mass, invasive ductal carcinoma with abundant stroma, central fibrosis/necrosis, and a higher degree of fat invasion correlated with EPE (P < 0.001). DRE correlated with lobulated or round mass with a smooth border, invasive ductal carcinoma with scanty stroma, higher degrees of inflammatory change and surrounding compressed tissue, and less fat invasion (P <0.001). EPE correlated with the ratio of the peripheral to central blood vessel density (P = 0.0036) and DRE with the ratio of the peritumoral to peripheral lymph vessel density (P = 0.0298).
  
  
  CONCLUSIONS
  The appearance of two different types of ring-like enhancement on dynamic MRI in breast cancers was affected by the morphologic features, various histological factors reflecting the growth pattern of the mass, and angiogenesis and lymphangiogenesis.
authors.affiliation: Department of Radiology, Graduate School of Medical Sciences Kanazawa University, Kanazawa, Japan. mirai@rad.m.kanazawa-u.ac.jp
authors.forename: Miki
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Hiroko
authors.initials: H
authors.lastname: Kawashima
authors.forename: Osamu
authors.initials: O
authors.lastname: Matsui
authors.forename: Yoh
authors.initials: Y
authors.lastname: Zen
authors.forename: Masayuki
authors.initials: M
authors.lastname: Suzuki
authors.forename: Masafumi
authors.initials: M
authors.lastname: Inokuchi
authors.forename: Masakuni
authors.initials: M
authors.lastname: Noguchi
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Ohta
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000473:pathology*; D016009:Chi-Square Distribution; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D012189:Retrospective Studies; D018709:Statistics, Nonparametric
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA