title: Ribosome's mode of function: myths, facts and recent results.
abstract: Ribosomes translate the genetic code into proteins in all living cells with extremely high efficiency, owing to their inherent flexibility and to their spectacular architecture. During the last 6 decades, extensive effort has been made to elucidate the molecular mechanisms associated with their function, and a quantum jump has been made in recent years, once the three dimensional structures of ribosomes and their functional complexes have been determined. These illuminated key issues in ribosome function, confirmed various biochemical, genetic, and medical findings, and revealed mechanistic details beyond previous expectation, thus leading to conceptual revolutions, and turning old myths into actual facts.
authors.affiliation: Weizmann Inst of Science, Rehovot, 76100, Israel.
authors.forename: Itai
authors.initials: I
authors.lastname: Wekselman
authors.forename: Chen
authors.initials: C
authors.lastname: Davidovich
authors.forename: Ilana
authors.initials: I
authors.lastname: Agmon
authors.forename: Ella
authors.initials: E
authors.lastname: Zimmerman
authors.forename: Haim
authors.initials: H
authors.lastname: Rozenberg
authors.forename: Anat
authors.initials: A
authors.lastname: Bashan
authors.forename: Rita
authors.initials: R
authors.lastname: Berisio
authors.forename: Ada
authors.initials: A
authors.lastname: Yonath
mesh_terms: D000818:Animals; D001665:Binding Sites; D006801:Humans; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry / Q000378:metabolism; D011487:Protein Conformation; D012269:Ribosomal Proteins / Q000737:chemistry / Q000378:metabolism; D012270:Ribosomes / Q000737:chemistry / Q000378:metabolism*
chemical_list: D010455:Peptides; D012269:Ribosomal Proteins