title: Generation of induced pluripotent stem cells from adult rhesus monkey fibroblasts.
abstract: Induced pluripotent stem (iPS) cells can be generated from somatic cells by transduction with several transcription factors in mouse and human. However, direct reprogramming in other species has not been reported. Here, we generated monkey iPS cells by retrovirus-mediated introduction of monkey transcription factors OCT4, SOX2, KLF4, and c-MYC.
authors.forename: Haisong
authors.initials: H
authors.lastname: Liu
authors.forename: Fangfang
authors.initials: F
authors.lastname: Zhu
authors.forename: Jun
authors.initials: J
authors.lastname: Yong
authors.forename: Pengbo
authors.initials: P
authors.lastname: Zhang
authors.forename: Pingping
authors.initials: P
authors.lastname: Hou
authors.forename: Honggang
authors.initials: H
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Jiang
authors.forename: Jun
authors.initials: J
authors.lastname: Cai
authors.forename: Meng
authors.initials: M
authors.lastname: Liu
authors.forename: Kai
authors.initials: K
authors.lastname: Cui
authors.forename: Xiuxia
authors.initials: X
authors.lastname: Qu
authors.forename: Tingting
authors.initials: T
authors.lastname: Xiang
authors.forename: Danyu
authors.initials: D
authors.lastname: Lu
authors.forename: Xiaochun
authors.initials: X
authors.lastname: Chi
authors.forename: Ge
authors.initials: G
authors.lastname: Gao
authors.forename: Weizhi
authors.initials: W
authors.lastname: Ji
authors.forename: Mingxiao
authors.initials: M
authors.lastname: Ding
authors.forename: Hongkui
authors.initials: H
authors.lastname: Deng
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D018929:Cell Culture Techniques / Q000379:methods; D002454:Cell Differentiation / Q000187:drug effects / Q000235:genetics*; D049109:Cell Proliferation / Q000187:drug effects; D048430:Cell Shape / Q000187:drug effects / Q000235:genetics; D002478:Cells, Cultured; D003470:Culture Media / Q000737:chemistry / Q000494:pharmacology; D047108:Embryonic Development / Q000235:genetics; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000235:genetics; D005822:Genetic Vectors / Q000235:genetics; D005855:Germ Layers / Q000166:cytology / Q000378:metabolism; D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Factors / Q000235:genetics; D008253:Macaca mulatta / Q000033:anatomy & histology / Q000502:physiology*; D008297:Male; D050814:Octamer Transcription Factor-3 / Q000235:genetics; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000378:metabolism*; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics; D012190:Retroviridae / Q000235:genetics; D055748:SOXB1 Transcription Factors / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics*; D014161:Transduction, Genetic / Q000379:methods*
chemical_list: D015415:Biomarkers; D003470:Culture Media; C000715467:KLF4 protein, human; C000715468:Klf4 protein, mouse; D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Factors; D050814:Octamer Transcription Factor-3; C494173:POU5F1 protein, human; D016271:Proto-Oncogene Proteins c-myc; C527782:SOX2 protein, human; D055748:SOXB1 Transcription Factors; D014157:Transcription Factors