title: Dumbbell-shaped peripheral primitive neuroectodermal tumor of the spine--case report and review of the literature.
abstract: Primary spinal peripheral primitive neuroectodermal tumors (pPNETs) are extremely rare. Here, we present a case study of a 29-year-old male with a dumbbell-shaped pPNET at the T9-10 spine level, including details of his examination, surgical procedures applied, histological and genetic findings, and his subsequent treatment. We discuss the clinical course, the pathology and treatment for this disease, the surgical approach to thoracic dumbbell tumors and we review the literature. To our knowledge, this is the first report of a case of a dumbbell-shaped intradural and spinal peripheral PNET.
authors.affiliation: University Hospital Olomouc, Olomouc, Czech Republic. lumir.hrabalek@seznam.cz
authors.forename: Lumír
authors.initials: L
authors.lastname: Hrabálek
authors.forename: Ondrej
authors.initials: O
authors.lastname: Kalita
authors.forename: Hana
authors.initials: H
authors.lastname: Svebisova
authors.forename: Jiri
authors.initials: J
authors.lastname: Ehrmann
authors.forename: Marian
authors.initials: M
authors.lastname: Hajduch
authors.forename: Radek
authors.initials: R
authors.lastname: Trojanec
authors.forename: Miroslav
authors.initials: M
authors.lastname: Kala
mesh_terms: D000328:Adult; D002148:Calmodulin-Binding Proteins; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D015321:Gene Rearrangement; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008279:Magnetic Resonance Imaging; D008297:Male; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D019635:Neurosurgical Procedures; D034802:RNA-Binding Protein EWS; D016601:RNA-Binding Proteins; D018714:Radiotherapy, Adjuvant; D013125:Spinal Neoplasms / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D013904:Thoracic Vertebrae
chemical_list: D002148:Calmodulin-Binding Proteins; C500986:EWSR1 protein, human; D034802:RNA-Binding Protein EWS; D016601:RNA-Binding Proteins