title: Effect of uridine of presynaptic NMDA and kainate receptor of rat brain cortex.
abstract: It was demonstrated that uridine affects presynaptic NMDA and kainite receptors of rat brain cortex. Uridine considerably inhibited (45)Ca2+ uptake into synaptoneurosomes (IC50 = 7.1 x 10(-12) M) under conditions NMDA stimulation and increased it under conditions AMPA stimulation (157.8%).
authors.affiliation: Laboratory of Neurochemistry of Physiologically Active Substances, Institute of Physiologically Active Substances, Russian Academy of Sciences, Chemogolovka, Moscow Region. plv@icp.ac.ru
authors.forename: L N
authors.initials: LN
authors.lastname: Petrova
authors.forename: A V
authors.initials: AV
authors.lastname: Gabrelian
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects*; D051381:Rats; D018092:Kainic Acid Receptors / Q000187:drug effects*; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects; D013574:Synaptosomes / Q000378:metabolism*; D014529:Uridine / Q000494:pharmacology*
chemical_list: D002118:Calcium; D018092:Kainic Acid Receptors; D016194:Receptors, N-Methyl-D-Aspartate; D014529:Uridine