title: Efficacy of fenbendazole formulated in a commercial primate diet for treating specific pathogen-free baboons (Papio cynocephalus anubis) infected with Trichuris trichiura.
abstract: Trichuris trichiura is a common intestinal nematode parasite of captive baboons. We evaluated the efficacy of fenbendazole formulated in a commercial primate diet (FBZ-PD) for treating specific pathogen-free (SPF) baboons (Papio cynocephalus anubis) naturally infected with Trichuris trichiura. Twenty-nine baboons, housed indoors in 3 separate rooms, were fed FBZ-PD for 5 d, whereas 4 baboons housed in another isolated area served as untreated controls. The efficacy of FBZ-PD was measured as reduction in the number of T. trichiura eggs in host feces after treatment as determined by quantitative fecal flotation examination. All baboons that received FBZ-PD stopped shedding T. trichiura eggs by 7 d after initiation of treatment, and remained negative until at least 119 d after treatment. However, eggs of T. trichiura were present in the feces of 3 (10.3%) experimental baboons at 154 d after treatment. Untreated control baboons shed T. trichiura eggs throughout the entire study. Our results indicate that FBZ-PD was efficacious for treating SPF baboons infected with T. trichiura.
authors.affiliation: Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, USA. mason.reichard@okstate.edu
authors.forename: Mason V
authors.initials: MV
authors.lastname: Reichard
authors.forename: Roman F
authors.initials: RF
authors.lastname: Wolf
authors.forename: Lindsay C
authors.initials: LC
authors.lastname: Clingenpeel
authors.forename: Sandra K
authors.initials: SK
authors.lastname: Doan
authors.forename: Amy N
authors.initials: AN
authors.lastname: Jones
authors.forename: Kristene M
authors.initials: KM
authors.lastname: Gray
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000008:administration & dosage*; D004032:Diet; D005243:Feces / Q000469:parasitology; D005273:Fenbendazole / Q000008:administration & dosage*; D048548:Papio cynocephalus / Q000469:parasitology*; D010270:Parasite Egg Count; D013047:Specific Pathogen-Free Organisms; D014257:Trichuriasis / Q000188:drug therapy / Q000662:veterinary*; D014258:Trichuris
chemical_list: D000969:Antinematodal Agents; D005273:Fenbendazole