The ketogenic diet--update on recent clinical trials.
The ketogenic diet (KD) has been used in the treatment of epilepsy for almost 100 years. Several cohort studies have emphasized its possible benefit, although use became less at the introduction of anticonvulsant medication. However, the KD has regained recognition over the past 15 years. Resources remain scarce and its availability for children may be limited. One argument has been the lack of evidence from suitably designed trials. Systematic reviews and meta-analyses have revealed that studies are limited to class 3 and 4 data. A recently published randomized controlled trial has shown that the benefit of the KD is equivalent to any of the new anticonvulsant medications, emphasizing the need for more resources to ensure greater diet availability.
Cross
J Helen
JH
UCL-Institute of Child Health, London, UK. hcross@ich.ucl.ac.uk
Neal
Elizabeth G
EG
D002986:Clinical Trials as Topic; D055423:Diet, Ketogenic; D004827:Epilepsy / Q000178:diet therapy*; D006801:Humans