title: Protocols for the in silico design of RNA nanostructures.
abstract: Recent developments in the field of nanobiology have significantly expanded the possibilities for new modalities in the treatment of many diseases, including cancer. Ribonucleic acid (RNA) represents a relatively new molecular material for the development of these biologically oriented nanodevices. In addition, RNA nanobiology presents a relatively new approach for the development of RNA-based nanoparticles that can be used as crystallization substrates and scaffolds for RNA-based nanoarrays. Presented in this chapter are some methodological shaped-based protocols for the design of such RNA nanostructures. Included are descriptions and background materials describing protocols that use a database of three-dimensional RNA structure motifs; designed RNA secondary structure motifs; and a combination of the two approaches. An example is also given illustrating one of the protocols.
authors.affiliation: Center for Cancer Research Nanobiology Program, National Cancer Institute, Frederick, MD, USA.
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Shapiro
authors.forename: Eckart
authors.initials: E
authors.lastname: Bindewald
authors.forename: Wojciech
authors.initials: W
authors.lastname: Kasprzak
authors.forename: Yaroslava
authors.initials: Y
authors.lastname: Yingling
mesh_terms: D019295:Computational Biology / Q000379:methods*; D030541:Databases, Genetic; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry*
chemical_list: D012313:RNA