[Synthesis and characterization of thermosensitive hydrogel based on PEG-PCL-PEG block copolymers].
In this paper, a series of low-molecular-weight PEG-PCL-PEG triblock copolymers were successfully synthesized by ring-opening polymerization method, and were characterized using 1H-NMR and FTIR. The aqueous solution displayed specific thermosensitive gel-sol transition when the concentration was above corresponding critical gel concentration (CGC). The gel-sol phase diagram was recorded using test tube-inverting method, which was depended on the hydrophilic/hydrophobic balance in macromolecular structure, as well as heating history. As a result, the gel-sol transition temperature range could be altered, which might be very useful for its application as injectable drug delivery system.
Gong
Changyang
C
State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Gu
Yingchun
Y
Xie
Zhen
Z
Xie
Xihui
X
Liu
Caibing
C
Kan
Bing
B
Tu
Mingjing
M
Wei
Yuquan
Y
Qian
Zhiyong
Z
D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D011091:Polyesters / Q000138:chemical synthesis* / Q000737:chemistry; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature
D001672:Biocompatible Materials; D004337:Drug Carriers; D011091:Polyesters; C502908:poly(ethylene glycol)-poly(caprolactone)-poly(ethylene glycol); D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols