Convenient one-pot synthesis of 2-oxazolines from carboxylic acids.
Simple one-pot methods for preparation of 2-oxazolines have been developed using 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM). Treatment of a mixture of carboxylic acids and 2-haloethylammonium salts with DMT-MM in methanol followed by refluxing in the presence of KOH gives oxazolines.
Hioki
Kazuhito
K
Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Chuo-ku, Koba, Japan.
Takechi
Yumiko
Y
Kimura
Noriyo
N
Tanaka
Hiroyuki
H
Kunishima
Munetaka
M
D002264:Carboxylic Acids / Q000737:chemistry*; D006878:Hydroxides; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D000432:Methanol; D010080:Oxazoles / Q000138:chemical synthesis*; D017680:Potassium Compounds; D013055:Spectrophotometry, Infrared
D002264:Carboxylic Acids; D006878:Hydroxides; D007202:Indicators and Reagents; D010080:Oxazoles; D017680:Potassium Compounds; C029943:potassium hydroxide; D000432:Methanol