Beneficial effects of resveratrol on atherosclerosis.
Atherosclerosis, a progressive disease characterized by the accumulation of lipids and fibrous elements in the arteries, is a most important contributor to cardiovascular diseases. Resveratrol is a naturally occurring phytopolyphenol compound and shows the ability to reduce the risk of cardiovascular diseases. In this review, beneficial effects of resveratrol on the initiation and progression of atherosclerosis, including regulation of vasodilator and vasoconstrictor production, inhibition of oxidative stress/reactive oxygen species generation, anti-inflammation, inhibition of modification of low-density lipoproteins, anti-platelet aggregation, and its abilities to impede progression and modulate complications of atherosclerosis, are discussed.
Fan
Enguo
E
College of Life Sciences, Nankai University, Tian Jin, People's Republic of China. fan@pflanzenphys.uni-halle.de
Zhang
Lijuan
L
Jiang
Sha
S
Bai
Yuhua
Y
D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D050197:Atherosclerosis / Q000188:drug therapy / Q000517:prevention & control*; D008078:Cholesterol, LDL / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D008517:Phytotherapy; D010974:Platelet Aggregation / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000378:metabolism; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000378:metabolism; D027843:Vitis
D000975:Antioxidants; D008078:Cholesterol, LDL; D017382:Reactive Oxygen Species; D013267:Stilbenes; D014665:Vasodilator Agents; D000077185:Resveratrol