title: Syndecan-1 plasma levels during coronary artery bypass surgery with and without cardiopulmonary bypass.
abstract: The glycocalyx covering the endothelium is shed during ischemia and reperfusion. The shedding is accompanied by increased levels of the glycocalyx component syndecan-1 in the circulation. Our aim was to compare plasma levels of syndecan-1 in patients undergoing coronary artery bypass grafting (CABG), with or without the use of cardiopulmonary bypass (CPB). Syndecan-1 plasma concentrations were measured in patients undergoing CABG on-pump (nA =A 22) or off-pump (nA =A 22). The syndecan-1 concentration increased significantly from 29.5 +/- 4.6 ng/mL at baseline to 98.7 +/- 9.8 ng/mL (pA <A 0.01) after the start of CPB or 30 minutes after the induction of anesthesia in the off-pump group. There were no significant differences in peak syndecan-1 plasma concentrations between on-pump and off-pump patients. Plasma levels of syndecan-1 increased significantly during CABG, with or without the use of CPB. There were no significant differences in syndecan-1 concentrations in the two groups.
authors.affiliation: Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway. katja.svennevig@medisin.uio.no
authors.forename: K
authors.initials: K
authors.lastname: Svennevig
authors.forename: Tn
authors.initials: T
authors.lastname: Hoel
authors.forename: As
authors.initials: A
authors.lastname: Thiara
authors.forename: So
authors.initials: S
authors.lastname: Kolset
authors.forename: A
authors.initials: A
authors.lastname: Castelheim
authors.forename: Te
authors.initials: T
authors.lastname: Mollnes
authors.forename: F
authors.initials: F
authors.lastname: Brosstad
authors.forename: E
authors.initials: E
authors.lastname: Fosse
authors.forename: Jl
authors.initials: J
authors.lastname: Svennevig
mesh_terms: D000368:Aged; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D015331:Cohort Studies; D047549:Coronary Artery Bypass, Off-Pump / Q000009:adverse effects*; D016207:Cytokines / Q000097:blood; D005260:Female; D019276:Glycocalyx; D006331:Heart Diseases / Q000097:blood / Q000601:surgery*; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000097:blood*; D012307:Risk Factors; D053668:Syndecan-1 / Q000097:blood*
chemical_list: D016207:Cytokines; D053668:Syndecan-1