title: Role of MRI in the differentiation of ADEM from MS in children.
abstract: BACKGROUND
  Acute disseminated encephalomyelitis (ADEM) is typically a monophasic demyelinating disorder. However, a clinical presentation consistent with ADEM can also be the first manifestation of multiple sclerosis (MS), particularly in children. Quantitative analyses of MRI images from children with monophasic ADEM have yet to be compared with those from children with MS, and MRI criteria capable of distinguishing ADEM from MS at onset have yet to be derived.
  
  
  METHODS
  A retrospective analysis of MRI scans obtained at first attack from 28 children subsequently diagnosed with MS and 20 children with ADEM was performed. T2/fluid-attenuated inversion recovery hyperintense lesions were quantified and categorized according to location, description, and size. T1-weighted images before and after administration of gadolinium were evaluated for the presence of black holes and for gadolinium enhancement. Mean lesion counts and qualitative features were compared between groups and analyzed to create a proposed diagnostic model.
  
  
  RESULTS
  Total lesion number did not differentiate ADEM from MS, but periventricular lesions were more frequent in children with MS. Combined quantitative and qualitative analyses led to the following criteria to distinguish MS from ADEM: any two of 1) absence of a diffuse bilateral lesion pattern, 2) presence of black holes, and 3) presence of two or more periventricular lesions. Using these criteria, MS patients at first attack could be distinguished from monophasic ADEM patients with an 81% sensitivity and a 95% specificity.
  
  
  CONCLUSIONS
  MRI diagnostic criteria are proposed that may be useful in differentiating children experiencing the first attack of multiple sclerosis from those with monophasic acute disseminated encephalomyelitis.
authors.affiliation: Division of Pediatric Neurology, Department of Pediatrics, McMaster Children's Hospital, McMaster University, Hamilton, Canada. dcallen@mcmaster.ca
authors.forename: D J A
authors.initials: DJ
authors.lastname: Callen
authors.forename: M M
authors.initials: MM
authors.lastname: Shroff
authors.forename: H M
authors.initials: HM
authors.lastname: Branson
authors.forename: D K
authors.initials: DK
authors.lastname: Li
authors.forename: T
authors.initials: T
authors.lastname: Lotze
authors.forename: D
authors.initials: D
authors.lastname: Stephens
authors.forename: B L
authors.initials: BL
authors.lastname: Banwell
mesh_terms: D000293:Adolescent; D001921:Brain / Q000473:pathology; D002648:Child; D015331:Cohort Studies; D003287:Contrast Media; D003937:Diagnosis, Differential; D004673:Encephalomyelitis, Acute Disseminated / Q000175:diagnosis*; D005260:Female; D005682:Gadolinium; D006801:Humans; D016015:Logistic Models; D008279:Magnetic Resonance Imaging; D008297:Male; D009103:Multiple Sclerosis / Q000175:diagnosis*
chemical_list: D003287:Contrast Media; D005682:Gadolinium