Anion channels: regulation of ClC-3 by an orphan second messenger.
ClC-3 is a ubiquitously expressed chloride channel isoform whose biological function has been a matter of debate for many years. A recent study reporting its regulation by Ins(3,4,5,6)P(4) assigns novel transport functions and cellular roles to ClC-3 and identifies a regulatory pathway that affects epithelial transport and endosomal pH regulation.
Alekov
Alexi K
AK
Institut für Neurophysiologie, Medizinische Hochschule Hannover, Germany.
Fahlke
Christoph
C
D001692:Biological Transport; D002460:Cell Line; D018118:Chloride Channels / Q000037:antagonists & inhibitors / Q000502:physiology*; D006801:Humans; D007295:Inositol Phosphates / Q000378:metabolism / Q000502:physiology*; D020033:Protein Isoforms / Q000502:physiology; D015398:Signal Transduction
D018118:Chloride Channels; C115376:ClC-3 channel; D007295:Inositol Phosphates; D020033:Protein Isoforms