title: First report on a hyperepidemic clone of KPC-3-producing Klebsiella pneumoniae in Israel genetically related to a strain causing outbreaks in the United States.
abstract: A highly epidemic carbapenem-resistant clone of KPC-3-producing Klebsiella pneumoniae emerged in Israel in 2006, causing a nationwide outbreak. This clone was genetically related to outbreak strains from the United States isolated in 2000 but differed in KPC-carrying plasmids. The threat of the global spread of hyperepidemic, extensively drug-resistant bacterial strains should be recognized and confronted.
authors.affiliation: Division of Epidemiology, Tel Aviv Sourasky Medical Center, Israel. shiri_nv@tasmc.health.gov.il
authors.forename: Shiri
authors.initials: S
authors.lastname: Navon-Venezia
authors.forename: Azita
authors.initials: A
authors.lastname: Leavitt
authors.forename: Mitchell J
authors.initials: MJ
authors.lastname: Schwaber
authors.forename: J Kamile
authors.initials: JK
authors.lastname: Rasheed
authors.forename: Arjun
authors.initials: A
authors.lastname: Srinivasan
authors.forename: Jean B
authors.initials: JB
authors.lastname: Patel
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Carmeli
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics*; D015780:Carbapenems / Q000494:pharmacology; D004196:Disease Outbreaks; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D007557:Israel / Q000453:epidemiology; D007710:Klebsiella Infections / Q000453:epidemiology / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014481:United States / Q000453:epidemiology; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015780:Carbapenems; D001618:beta-Lactamases; C495220:beta-lactamase KPC-3, Klebsiella pneumoniae