title: Total synthesis of (-)-serotobenine.
abstract: The efficient total synthesis of (-)-serotobenine (1) has been achieved by constructing an optically active dihydrobenzofuran ring via a rhodium carbenoid mediated intramolecular C-H insertion reaction, which was developed by our group. Then the possibility of racemization of 1 was investigated using optically active synthetic 1.
authors.affiliation: School of Pharmaceutical Sciences, University of Shizuoka and Global COE Program, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Koizumi
authors.forename: Hideki
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Wakimoto
authors.forename: Takumi
authors.initials: T
authors.lastname: Furuta
authors.forename: Tohru
authors.initials: T
authors.lastname: Fukuyama
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kan
mesh_terms: D001572:Benzofurans / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D007536:Isomerism; D015394:Molecular Structure
chemical_list: D001572:Benzofurans; D007211:Indoles; C531376:serotobenine