title: Low-grade gingival leiomyosarcoma in a child.
abstract: Leiomyosarcoma (LMS) of the oral cavity, a rare mesenchymal tumor exhibiting smooth-muscle differentiation, is extremely uncommon in childhood. The most frequent location of childhood LMS is the gastrointestinal tract, particularly the stomach. The purpose of this paper is to report a case of leiomyosarcoma affecting the gingival tissues and mandible of a 9-year-old girl with peculiar clinical, microscopic, and radiographic features. Clinical and radiographical examinations revealed a gingival growth affecting the primary mandibular right first molar with inflammatory features. The lesion was initially suspected to be pyogenic granuloma and was removed by excisional biopsy. Microscopic findings showed a hypercellular proliferation of mesenchymal spindle cells, suggesting malignant spindle cell neoplasm. Immunohistochemical, histochemical, and radiographic studies were undertaken, and the final diagnosis established was a low-grade leiomyosarcoma in the gingiva.
authors.affiliation: Department of Stomatology (Oral Pathology), Dental School, Federal University of Goiás, Goiânia, Brazil. elismaur@odonto.ufg.br
authors.forename: Elismauro Francisco
authors.initials: EF
authors.lastname: Mendonça
authors.forename: Clóvis
authors.initials: C
authors.lastname: Martins da Silva
authors.forename: Alexandre João
authors.initials: AJ
authors.lastname: Meneghini
authors.forename: Geisa B L
authors.initials: GB
authors.lastname: Silva
authors.forename: João Alves A
authors.initials: JA
authors.lastname: Filho
authors.forename: Aline Carvalho
authors.initials: AC
authors.lastname: Batista
mesh_terms: D000199:Actins / Q000032:analysis; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D005887:Gingival Neoplasms / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D007890:Leiomyosarcoma / Q000737:chemistry / Q000473:pathology*; D008339:Mandibular Neoplasms / Q000737:chemistry / Q000473:pathology*
chemical_list: D000199:Actins