title: Evaluation of four topical preparations for the treatment of cannon hyperkeratosis in a horse.
abstract: The response to treatment with four topical preparations was evaluated in an 11-year-old Morgan horse mare with histologically confirmed quadrilateral cannon hyperkeratosis. Each limb was treated for 30 days with 0.1% tacrolimus ointment, 0.1% adapalene gel, 0.2% phytosphingosine spray or a water-based emollient. Response to treatment was evaluated both histologically and visually. A water-based emollient and 0.1% tacrolimus ointment produced encouraging clinical responses. Pre-treatment histopathology identified marked, mostly compact, hyperkeratosis and follicular hyperkeratosis, most prominent in the infundibular area. Following treatment, histopathology identified a mild reduction in follicular keratin production and stratum corneum thickness.
authors.affiliation: William R. Pritchard Veterinary Medical Teaching Hospital, University of California, Davis, California 95616, USA. hghilton@ucdavis.edu
authors.forename: Hugo
authors.initials: H
authors.lastname: Hilton
authors.forename: Verena K
authors.initials: VK
authors.lastname: Affolter
authors.forename: Stephen D
authors.initials: SD
authors.lastname: White
mesh_terms: D000068816:Adapalene; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D005260:Female; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007634:Keratitis / Q000188:drug therapy / Q000662:veterinary*; D009281:Naphthalenes / Q000627:therapeutic use*; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016559:Tacrolimus / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007166:Immunosuppressive Agents; D009281:Naphthalenes; D000068816:Adapalene; C012491:phytosphingosine; D013110:Sphingosine; D016559:Tacrolimus