title: Reciprocal influence of connexins and apical junction proteins on their expressions and functions.
abstract: Membranes of adjacent cells form intercellular junctional complexes to mechanically anchor neighbour cells (anchoring junctions), to seal the paracellular space and to prevent diffusion of integral proteins within the plasma membrane (tight junctions) and to allow cell-to-cell diffusion of small ions and molecules (gap junctions). These different types of specialised plasma membrane microdomains, sharing common adaptor molecules, particularly zonula occludens proteins, frequently present intermingled relationships where the different proteins co-assemble into macromolecular complexes and their expressions are co-ordinately regulated. Proteins forming gap junction channels (connexins, particularly) and proteins fulfilling cell attachment or forming tight junction strands mutually influence expression and functions of one another.
authors.affiliation: Institut de Physiologie et Biologie Cellulaires, Université de Poitiers, Poitiers, F-86022, France.
authors.forename: Mickaël
authors.initials: M
authors.lastname: Derangeon
authors.forename: David C
authors.initials: DC
authors.lastname: Spray
authors.forename: Nicolas
authors.initials: N
authors.lastname: Bourmeyster
authors.forename: Denis
authors.initials: D
authors.lastname: Sarrouilhe
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Hervé
mesh_terms: D000818:Animals; D017630:Connexins / Q000502:physiology*; D003598:Cytoskeletal Proteins / Q000502:physiology; D029721:Drosophila Proteins / Q000502:physiology; D006801:Humans; D007365:Intercellular Junctions / Q000502:physiology*; D008565:Membrane Proteins / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000502:physiology; D062793:Occludin; D010750:Phosphoproteins / Q000502:physiology; D025941:Protein Interaction Mapping; D019108:Tight Junctions / Q000502:physiology*; D062826:Zonula Occludens-1 Protein
chemical_list: D017630:Connexins; D003598:Cytoskeletal Proteins; D029721:Drosophila Proteins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C568985:OCLN protein, human; D062793:Occludin; C492764:PANX1 protein, human; D010750:Phosphoproteins; C569042:TJP1 protein, human; D062826:Zonula Occludens-1 Protein; C079326:ogre protein, Drosophila