title: Nanoelectronic interface for lab-on-a-chip devices.
abstract: Innovations in microfabricated analytical devices integrated with microelectronic circuits and biological cells show promising results in detection, diagnosis and analysis. Planar metallic microelectrodes are widely used for the electrical interface with the biological cells. Issues with the current microelectrode array design are the difficulty in selective integration with a cell, the size dependency of its impedance and the large amount of noise in the circuit due to this mismatch. It is quite evident that an approach utilising nanotechnology can solve some of these problems by yielding efficient electrical interconnections. The design and development of a planar microelectrode array integrated with vertically aligned nanowires for lab-on-a-chip (LoC) device applications are presented. The nanowire integrated microelectrode arrays for LoC devices show promising results with respect to impedance control due to increased surface area. The authors have fabricated nanowire integrated microelectrode arrays on silicon and flexible polymer substrates using the template method. A high degree of specific growth is achieved by controlling the nanowire synthesis parameters. An attempt has been made to integrate biological cells into the nanowires by culturing endothelial cells onto the microelectrode array.
authors.affiliation: Department of Electrical Engineering, University of Arkansas, Fayetteville, AR 72701, USA. kajose@uark.edu
authors.forename: J K
authors.initials: JK
authors.lastname: Abraham
authors.forename: H
authors.initials: H
authors.lastname: Yoon
authors.forename: R
authors.initials: R
authors.lastname: Chintakuntla
authors.forename: M
authors.initials: M
authors.lastname: Kavdia
authors.forename: V K
authors.initials: VK
authors.lastname: Varadan
mesh_terms: D018929:Cell Culture Techniques / Q000295:instrumentation; D002478:Cells, Cultured; D004581:Electronics / Q000295:instrumentation*; D042783:Endothelial Cells / Q000166:cytology / Q000502:physiology*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005434:Flow Cytometry / Q000295:instrumentation*; D006801:Humans; D008839:Microelectrodes; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D036103:Nanotechnology / Q000295:instrumentation*