title: Changes in carbohydrate metabolism during acclimation to a moderate hyperthermic environment in rats.
abstract: We studied the influence of heat acclimation (1 to 48 h and 4 to 60 d at 35 +/- 1 degrees C) on certain hepatic carbohydrate-related enzymes and substrates in rats. The results showed a decrease of liver glycogen content and GPho-ase a activity during the period of short-term exposure, followed by normalization to the control level and stabilization to the new level in the period of long-term heat acclimation. Conversely, G-6-P-ase and F-1,6-BP-ase activities increased during the short-term period, followed by a decrease and stabilization to a new, lower level in the prolonged acclimation. The blood glucose level decreased during whole period of acclimation, whereas intermediate substrates increased during the short-term and stabilized at a new, higher level during prolonged acclimation. The time-dependent changes of duration of heat acclimation could be summarized in three phases: short-term heat exposure (1 to 24 h) with intensive glycogenolysis and gluconeogenesis to glucose; a period with temporary changes (24 h to 7 d) with tendency of normalization to control level, and prolonged heat acclimation (7 d to 60 d), which favors both direct and indirect glycogen synthesis.
authors.affiliation: Department ofPhysiology and Biochemistry, Faculty of Natural Sciences and Mathematics, Gazi Baba bb, 1000 Skopje, R. Macedonia. bmiova@iunona.pmf.ukim.edu.mk
authors.forename: B
authors.initials: B
authors.lastname: Miova
authors.forename: S
authors.initials: S
authors.lastname: Dinevska-Kjovkarovska
authors.forename: S
authors.initials: S
authors.lastname: Mitev
mesh_terms: D000064:Acclimatization / Q000502:physiology*; D000818:Animals; D001786:Blood Glucose / Q000502:physiology; D006597:Fructose-Bisphosphatase / Q000378:metabolism; D005943:Gluconeogenesis / Q000502:physiology*; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D025001:Glycogen Phosphorylase, Liver Form / Q000378:metabolism; D050261:Glycogenolysis / Q000502:physiology*; D006358:Hot Temperature; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D008112:Liver Glycogen; D025001:Glycogen Phosphorylase, Liver Form; D006597:Fructose-Bisphosphatase; D005952:Glucose-6-Phosphatase