Respiratory and cardiovascular effects of biphalin in anaesthetized rats.
Biphalin (0.3 mg/kg) administered intravenously (i.v.) to urethane-chloralose anaesthetized rats consistently evoked apnoea, followed by breathing at subnormal respiratory rate with increased tidal volume. Mean arterial pressure and heart rate were lowered. Naloxone completely antagonized the respiratory and cardiovascular responses to biphalin. Midcervical vagotomy prevented all respiratory effects of biphalin, and nearly abolished the fall in blood pressure and attenuated bradycardia. These results indicate that mu opioid receptors distributed in areas supplied by vagal afferents (e.g. the lung) are involved in respiratory and hypotensive effects of biphalin, whereas bradycardia may be explained by activation of brainstem regions mediating cardiovascular control.
Wojciechowski
Piotr
P
Laboratory of Respiratory Reflexes, Polish Academy of Sciences Medical Research Centre, 02-106 Warsaw, 5 Pawińskiego St., Poland.
Szereda-Przestaszewska
Małgorzata
M
Lipkowski
Andrzej W
AW
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001919:Bradycardia / Q000139:chemically induced / Q000503:physiopathology; D002319:Cardiovascular System / Q000187:drug effects*; D002698:Chloralose / Q000494:pharmacology; D004745:Enkephalins / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011957:Receptors, Opioid / Q000378:metabolism; D012137:Respiratory System / Q000187:drug effects*; D013997:Time Factors; D014520:Urethane / Q000494:pharmacology; D014628:Vagotomy
D000700:Analgesics; D004745:Enkephalins; D011957:Receptors, Opioid; D002698:Chloralose; D009270:Naloxone; D014520:Urethane; C053673:biphalin