New metal-free one-pot synthesis of substituted allenes from enones.
A new metal-free, one-pot synthesis of substituted allenes from enones was discovered for the first time, in which a tertiary amine as a base was found to be an effective promoter in such novel transformations. The present synthetic protocol proceeded readily with high compatibility of sensitive functional groups, and it provides a new efficient way to access a series of synthetically important allenes without the use of metallic reagents or catalysts.
Tang
Meng
M
State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou 730000, PR China.
Fan
Chun-An
CA
Zhang
Fu-Min
FM
Tu
Yong-Qiang
YQ
Zhang
Wen-Xue
WX
Wang
Ai-Xia
AX
D000466:Alkadienes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
D000466:Alkadienes; C025947:propadiene