Immunohistochemical expression of multidrug resistance proteins in mature T/NK-cell lymphomas.
Multidrug resistance (MDR) is defined as resistance of tumor cells to a wide spectrum of structurally and functionally unrelated drugs. One of the most important mechanisms in mediating MDR is that involving cellular drug efflux transporters. Drug resistance is a common and formidable obstacle to therapy in mature T/NK-cell lymphomas and the MDR phenotype is thought to be one of the contributing mechanisms. In this study we assessed the immunohistochemical expression of P-gp (P-glycoprotein), MRP-1 (multidrug resistance associated protein 1), BCRP (breast cancer resistance protein) and LRP (lung resistance protein) in 45 mature T/NK-cell lymphomas diagnosed at our hospital. We detected P-gp expression in 31% (13/42), MRP-1 expression in 74% (31/42), BCRP in 78% (32/41) and LRP in 59% (26/44) of the cases. These findings show that our T/NK-cell lymphoma cases display high frequency of MDR protein expression.
Saglam
Arzu
A
Department of Pathology, Oncology Institute, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Hayran
Mutlu
M
Uner
Aysegul H
AH
D018435:ATP Binding Cassette Transporter, Subfamily B / Q000096:biosynthesis*; D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters / Q000096:biosynthesis*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D054391:Lymphoma, Extranodal NK-T-Cell / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000096:biosynthesis*; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D012189:Retrospective Studies; D020394:Vault Ribonucleoprotein Particles / Q000096:biosynthesis*; D055815:Young Adult; D000099187:Major Vault Protein
D018435:ATP Binding Cassette Transporter, Subfamily B; D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D009363:Neoplasm Proteins; D020394:Vault Ribonucleoprotein Particles; D000099187:Major Vault Protein; C116614:ABCG2 protein, human