title: Effects of aerobic exercise on non-high-density lipoprotein cholesterol in children and adolescents: a meta-analysis of randomized controlled trials.
abstract: The authors used the meta-analytic approach to examine the effects of aerobic exercise on non-high-density lipoprotein cholesterol (non-HDL-C) in children and adolescents. Thirteen non-HDL-C outcomes in 404 males and females (221 exercise, 183 control) were available for pooling. Random-effects modeling yielded a nonstatistically significant exercise minus control group reduction of 0.61% in non-HDL-C (X +/- SEM, -0.7 +/- 2.4 mg/dL, 95% confidence interval [CI], -5.4 to 5.0 mg/dL). A statistically significant decrease of 7% was found for percent body fat (X +/- SEM, -2.1 +/- 0.5%, 95% CI, -3.0 to -1.2%) as well as an 8% increase in aerobic capacity (X +/- SEM, 3.4 +/- 1.0 mL/kg/min, 95% CI, 1.4-5.3 mL/kg/min), both secondary outcomes of the study. It was concluded that aerobic exercise does not reduce non-HDL-C but does improve percent body fat and aerobic capacity in children and adolescents. However, a need exists for additional studies on this topic.
authors.affiliation: Meta-Analytic Research Group, School of Medicine, Department of Community Medicine, West Virginia University, Morgantown, WV 26506-9190, USA. gkelley@hsc.wvu.edu
authors.forename: George A
authors.initials: GA
authors.lastname: Kelley
authors.forename: Kristi S
authors.initials: KS
authors.lastname: Kelley
mesh_terms: D000293:Adolescent; D015982:Bias; D001835:Body Weight; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D002648:Child; D015362:Child Nutrition Disorders / Q000517:prevention & control; D008078:Cholesterol, LDL / Q000097:blood*; D015987:Effect Modifier, Epidemiologic; D015444:Exercise; D005081:Exercise Therapy / Q000379:methods; D017079:Exercise Tolerance; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000150:complications / Q000517:prevention & control*; D008297:Male; D009765:Obesity / Q000517:prevention & control; D016032:Randomized Controlled Trials as Topic; D012107:Research Design; D012680:Sensitivity and Specificity; D016896:Treatment Outcome
chemical_list: D008078:Cholesterol, LDL