title: A new hammer in the redox toolbox: high-purity peroxynitrite for cell signaling and toxicology studies.
abstract: A new chemical synthesis has been disclosed for the oxidizing and nitrating species peroxynitrite. This nitric oxide and superoxide-derived cell signaling mediator can also serve as a toxicant at higher rates of generation. The new synthetic strategy reported by Sturzbecher-Höhne and colleagues overcomes long-standing issues with purity and quality of peroxynitrite preparations and should lay a foundation for nailing new insight into the redox reactions of peroxynitrite and its products.
authors.affiliation: Department of Pharmacology & Chemical Biology, University of Pittsburgh, E1340 Biomedical Science Tower, Pittsburgh, Pennsylvania 15261, USA.
authors.forename: Steven R
authors.initials: SR
authors.lastname: Woodcock
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Freeman
mesh_terms: D006861:Hydrogen Peroxide / Q000737:chemistry; D008928:Mitochondria / Q000378:metabolism; D009569:Nitric Oxide / Q000737:chemistry; D019001:Nitric Oxide Synthase / Q000378:metabolism; D016877:Oxidants / Q000096:biosynthesis / Q000138:chemical synthesis*; D010084:Oxidation-Reduction; D030421:Peroxynitrous Acid / Q000096:biosynthesis / Q000138:chemical synthesis*; D015398:Signal Transduction / Q000502:physiology*; D018675:Toxicity Tests / Q000379:methods*
chemical_list: D016877:Oxidants; D030421:Peroxynitrous Acid; D009569:Nitric Oxide; D006861:Hydrogen Peroxide; D019001:Nitric Oxide Synthase