Transmission of atypical bovine prions to mice transgenic for human prion protein.
To assess risk for cattle-to-human transmission of prions that cause uncommon forms of bovine spongiform encephalopathy (BSE), we inoculated mice expressing human PrP Met129 with field isolates. Unlike classical BSE agent, L-type prions appeared to propagate in these mice with no obvious transmission barrier. H-type prions failed to infect the mice.
Béringue
Vincent
V
Institut National de la Recherche Agronomique, Jouy-en-Josas, France. vincent.beringue@jouy.inra.fr
Herzog
Laëtitia
L
Reine
Fabienne
F
Le Dur
Annick
A
Casalone
Cristina
C
Vilotte
Jean-Luc
JL
Laude
Hubert
H
D000818:Animals; D001921:Brain / Q000378:metabolism; D002417:Cattle; D016643:Encephalopathy, Bovine Spongiform / Q000635:transmission*; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D018620:PrPSc Proteins / Q000378:metabolism; D011328:Prions / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D019076:Transgenes
D018620:PrPSc Proteins; D011328:Prions