title: Haemostatic factors in women with history of preeclampsia.
abstract: OBJECTIVE
  Evaluation of haemostatic parameters--Plasma tissue plasminogen activator (t-PA), plasminogen activator inhibitor type 1 (PAI-1) and fibrin fragment D-dimer several years after the end of pregnancy to investigate if they are modified in women with history of preeclampsia (PE).
  
  
  METHODS
  65 healthy women with history of PE and 54 control women with previous normal pregnancy were enrolled in this study. Groups were matched for age, time period since delivery, smoking status and alcohol consumption. t-PA, PAI-1 and fibrin fragment D-dimer antigen levels were quantified using standards commercial ELISA methods. Plasma fibrinogen was measured using automated capillary zone electrophoresis.
  
  
  RESULTS
  Systolic and diastolic blood pressures were higher in women with history of PE. Levels of t-PA, PAI-1 and fibrinogen were similar between groups as well as the t-PA/PAI-1 ratio. A significant increase in D-dimer levels was observed in women with history of PE.
  
  
  CONCLUSIONS
  The increase in D-dimer level suggests an abnormal haemostatic potential namely increased intravascular coagulation. This, together with the increased blood pressure, can reflect a tendency for an increased risk of cardiovascular/thrombotic events later in life.
authors.affiliation: Institute for Molecular and Cell Biology, University of Porto, Portugal. aportelinha@gmail.com
authors.forename: Ana
authors.initials: A
authors.lastname: Portelinha
authors.forename: Ana Sofia
authors.initials: AS
authors.lastname: Cerdeira
authors.forename: Luís
authors.initials: L
authors.lastname: Belo
authors.forename: Jorge
authors.initials: J
authors.lastname: Braga
authors.forename: Eduardo
authors.initials: E
authors.lastname: Tejera
authors.forename: Ana
authors.initials: A
authors.lastname: Pinto
authors.forename: Fátima
authors.initials: F
authors.lastname: Pinto
authors.forename: Maria José
authors.initials: MJ
authors.lastname: Areias
authors.forename: Belmiro
authors.initials: B
authors.lastname: Patrício
authors.forename: Irene
authors.initials: I
authors.lastname: Rebelo
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D019281:Dimerization; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis* / Q000378:metabolism; D005340:Fibrinogen / Q000032:analysis*; D006487:Hemostasis; D006801:Humans; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D010959:Tissue Plasminogen Activator / Q000097:blood*
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D017395:Plasminogen Activator Inhibitor 1; C036309:fibrin fragment D; D005340:Fibrinogen; D010959:Tissue Plasminogen Activator