Evaluation of older persons with mild cognitive deficits: potential utility of magnetic resonance imaging.
BACKGROUND
This study evaluated brain volumes in healthy older subjects without dementia who presented with memory complaints. The objective was to examine cortical volumes in relation to cognitive performance among patients who do not have dementia, but who do have mild cognitive deficits.


METHODS
Fifteen participants were evaluated (mean age = 71.8 +/- 6.2). Brain structure was measured via high-resolution magnetic resonance imaging to quantify gray and white matter volumes. Volumetric measures were assessed relative to cognitive function in separate regression models controlling for total cerebral volume. Reported here are measures of global cognitive performance using the Mattis Dementia Rating Scale (DRS) in relation to volumetric measures.


RESULTS
Baseline MMSE scores ranged from 27 to 30 (mean = 29.3; SD = 0.9). After controlling for total cerebral volume, we observed that lower white matter volume in the temporal lobe [F(1,14) = 5.72, p = 0.03] was associated with lower performance on the Mattis Dementia Rating Scale (DRS).


CONCLUSIONS
Structural imaging may help provide useful clinical information in the context of mild cognitive decline. Currently, the diagnosis of dementia relies on longitudinal measures of cognition. Future studies will help determine whether the addition of brain imaging may enhance diagnostic certainty as well as predict long-term outcome.
Schultz
Susan K
SK
University of Iowa Department of Psychiatry, Carver College of Medicine, Iowa City, IA 52242-1000, USA. Susan-schultz@uiowa.edu
Magnotta
Vincent
V
Duff
Kevin
K
Boles Ponto
Laurie L
LL
Moser
David J
DJ
D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D003072:Cognition Disorders / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004185:Disability Evaluation; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis*; D008609:Mental Status Schedule; D009483:Neuropsychological Tests; D009929:Organ Size / Q000502:physiology; D013702:Temporal Lobe / Q000473:pathology