Photostability of pitavastatin--a novel HMG-CoA reductase inhibitor.
The photostability of pitavastatin, an HMG-CoA reductase inhibitor used in the treatment of hypercholesterolemia, was investigated. The sample solution was exposed to UV-A radiation and the photodegradation process was monitored by means of spectrophotometric method and HPLC-DAD. Pitavastatin was shown to be photolabile and its photodegradation reaction followed the first-order kinetics with the rate constant k=3.54 x 10(-4)+/-9.43 x 10(-6)s(-1). The chromatograms revealed the presence of four major photoproducts (PP-1-PP-4). The separated and isolated photolytic products were identified using a mass spectrometer coupled with a time of flight (TOF) analyzer. The main reaction observed during exposure to radiation of pitavastatin was photocyclisation leading to formation of four-ring photoproducts.
Grobelny
Paweł
P
Poznan University of Medical Sciences, Department of Pharmaceutical Technology, Grunwaldzka 6, 60-780 Poznań, Poland.
Viola
Giampietro
G
Vedaldi
Daniela
D
Dall'Acqua
Francesco
F
Gliszczyńska-Swigło
Anna
A
Mielcarek
Jadwiga
J
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004355:Drug Stability; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000737:chemistry*; D006937:Hypercholesterolemia / Q000188:drug therapy; D013058:Mass Spectrometry / Q000379:methods; D011804:Quinolines / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D014466:Ultraviolet Rays
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011804:Quinolines; C108475:pitavastatin