An overview of hazard and risk assessment of the OECD high production volume chemical category--long chain alcohols [C(6)-C(22)] (LCOH).
This review summarizes the findings of the assessment report for the category, long chain alcohols (LCOH) with a carbon chain length range of C(6)-C(22) covering 30 substances, and >1.5million tonnes/year consumed globally. The category was evaluated under the Organization for Economic Co-operation and Development (OECD) high production volume chemicals program in 2006. The main findings of the assessment include: (1) no unacceptable human or environmental risks were identified; (2) these materials are rapidly and readily biodegradable; (3) a parabolic relationship was demonstrated between carbon chain length and acute and chronic aquatic toxicity; (4) category-specific (quantitative) structure-activity relationships were developed enabling prediction of properties across the entire category; (5) LCOH occur naturally in the environment in an equilibrium between synthesis and degradation; (6) industry coming together and sharing resources results in minimizing the need for additional animal tests, produces cost savings, and increases scientific quality of the assessment.
Sanderson
Hans
H
The Soap and Detergent Association, Washington, District of Columbia, DC 20005, USA. hasa@dmu.dk
Belanger
Scott E
SE
Fisk
Peter R
PR
Schäfers
Christoph
C
Veenstra
Gauke
G
Nielsen
Allen M
AM
Kasai
Yutaka
Y
Willing
Andreas
A
Dyer
Scott D
SD
Stanton
Kathleen
K
Sedlak
Richard
R
D000818:Animals; D001673:Biodegradation, Environmental; D002617:Chemical Industry; D003621:Daphnia; D004784:Environmental Monitoring; D005233:Fatty Alcohols / Q000737:chemistry / Q000633:toxicity*; D006801:Humans; D008322:Mammals; D018570:Risk Assessment; D012995:Solubility; D014835:Volatilization; D014874:Water Pollutants, Chemical / Q000737:chemistry / Q000633:toxicity
D005233:Fatty Alcohols; D014874:Water Pollutants, Chemical