title: Development of clindamycin-loaded wound dressing with polyvinyl alcohol and sodium alginate.
abstract: To develop a clindamycin-loaded wound dressing, cross-linked hydrogel films were prepared using freeze-thawing method with various mixtures of polyvinyl alcohol (PVA) and sodium alginate (SA). The physicochemical properties such as swelling ratio, tensile strength and elongation of hydrogels were evaluated. The drug release from this clindamycin-loaded hydrogel, in vitro protein adsorption test and in vivo wound healing observations in rats were then performed. Increased SA concentration decreased the gelation %, maximum strength and break elongation, but it resulted into an increment in the swelling ability, elasticity and thermal stability of hydrogel film. However, SA had insignificant effect on the release of clindamycin. This hydrogel improved the healing rate of artificial wounds in rats. Thus, a clindamycin-loaded wound dressing with PVA and SA hydrogel should be a candidate for wound care.
authors.affiliation: Dong-A Pharm. Co., Ltd., Yongin-Si, Kyunggi-Do 449-905, South Korea.
authors.forename: Jong Oh
authors.initials: JO
authors.lastname: Kim
authors.forename: Jun Young
authors.initials: JY
authors.lastname: Choi
authors.forename: Jung Kil
authors.initials: JK
authors.lastname: Park
authors.forename: Jeong Hoon
authors.initials: JH
authors.lastname: Kim
authors.forename: Sung Giu
authors.initials: SG
authors.lastname: Jin
authors.forename: Sun Woo
authors.initials: SW
authors.lastname: Chang
authors.forename: Dong Xun
authors.initials: DX
authors.lastname: Li
authors.forename: Ma-Ro
authors.initials: MR
authors.lastname: Hwang
authors.forename: Jong Soo
authors.initials: JS
authors.lastname: Woo
authors.forename: Jung-Ae
authors.initials: JA
authors.lastname: Kim
authors.forename: Won Seok
authors.initials: WS
authors.lastname: Lyoo
authors.forename: Chul Soon
authors.initials: CS
authors.lastname: Yong
authors.forename: Han-Gon
authors.initials: HG
authors.lastname: Choi
mesh_terms: D000042:Absorption; D000464:Alginates / Q000737:chemistry*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001458:Bandages; D002981:Clindamycin / Q000008:administration & dosage*; D003432:Cross-Linking Reagents; D004355:Drug Stability; D005079:Excipients; D005615:Freezing; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D020100:Hydrogels; D008297:Male; D008422:Materials Testing; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000473:pathology; D013499:Surface Properties; D013718:Tensile Strength; D014947:Wounds and Injuries / Q000473:pathology / Q000628:therapy
chemical_list: D000464:Alginates; D000900:Anti-Bacterial Agents; D003432:Cross-Linking Reagents; D005079:Excipients; D006603:Hexuronic Acids; D020100:Hydrogels; D011506:Proteins; D002981:Clindamycin; D020723:Glucuronic Acid; D011142:Polyvinyl Alcohol