title: Antiplasmodial benzophenones from the trunk latex of Moronobea coccinea (Clusiaceae).
abstract: In an effort to find antimalarial drugs, a systematic in vitro evaluation on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) was undertaken on sixty plant extracts collected in French Guiana. The methanol extract obtained from the latex of Moronobea coccinea exhibited a strong antiplasmodial activity (95% at 10microg/ml). The phytochemical investigation of this extract led to the isolation of eleven polycyclic polyprenylated acylphloroglucinols (PPAPs), from which eight showed potent antiplasmodial activity with IC50 ranged from 3.3microM to 37.2microM.
authors.affiliation: Institut de Chimie des Substances Naturelles, 1, avenue de la Terrasse, CNRS, 91198 Gif-sur-Yvette, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Marti
authors.forename: Véronique
authors.initials: V
authors.lastname: Eparvier
authors.forename: Christian
authors.initials: C
authors.lastname: Moretti
authors.forename: Sophie
authors.initials: S
authors.lastname: Susplugas
authors.forename: Soizic
authors.initials: S
authors.lastname: Prado
authors.forename: Philippe
authors.initials: P
authors.lastname: Grellier
authors.forename: Pascal
authors.initials: P
authors.lastname: Retailleau
authors.forename: Françoise
authors.initials: F
authors.lastname: Guéritte
authors.forename: Marc
authors.initials: M
authors.lastname: Litaudon
mesh_terms: D000818:Animals; D001577:Benzophenones / Q000737:chemistry* / Q000494:pharmacology*; D028084:Clusiaceae / Q000737:chemistry*; D007840:Latex / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D001577:Benzophenones; D007840:Latex