Vitamin D status and muscle function in post-menarchal adolescent girls.
BACKGROUND
There has been a resurgence of vitamin D deficiency among infants, toddlers, and adolescents in the United Kingdom. Myopathy is an important clinical symptom of vitamin D deficiency, yet it has not been widely studied.


OBJECTIVE
Our objective was to investigate the relationship of baseline serum 25 hydroxyvitamin D [25(OH)D] concentration and PTH with muscle power and force.


METHODS
This was a cross-sectional study.


METHODS
The study was community based in a secondary school.


METHODS
A total of 99 post-menarchal 12- to 14-yr-old females was included in the study.


METHODS
Jumping mechanography to measure muscle power, velocity, jump height, and Esslinger Fitness Index from a two-legged counter movement jump and force from multiple one-legged hops was performed. Body height, weight, and serum concentrations of 25(OH)D, PTH, and calcium were measured.


RESULTS
Median serum 25(OH)D concentration was 21.3 nmol/liter (range 2.5-88.5) and PTH 3.7 pmol/liter (range 0.47-26.2). After correction for weight using a quadratic function, there was a positive relationship between 25(OH)D and jump velocity (P = 0.002), jump height (P = 0.005), power (P = 0.003), Esslinger Fitness Index (P = 0.003), and force (P = 0.05). There was a negative effect of PTH upon jump velocity (P = 0.04).


CONCLUSIONS
From these data we conclude that vitamin D was significantly associated with muscle power and force in adolescent girls.
Ward
Kate A
KA
Imaging Science and Biomedical Engineering, University of Manchester, Manchester, United Kingdom. Kate.Ward@mrc-hnr.cam.ac.uk
Das
Geeta
G
Berry
Jacqueline L
JL
Roberts
Stephen A
SA
Rawer
Rainer
R
Adams
Judith E
JE
Mughal
Zulf
Z
D000293:Adolescent; D017195:Adolescent Nutritional Physiological Phenomena; D054874:Athletic Performance / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008572:Menarche / Q000097:blood / Q000502:physiology; D053580:Muscle Strength / Q000502:physiology; D018482:Muscle, Skeletal / Q000502:physiology*; D010281:Parathyroid Hormone / Q000097:blood; D014807:Vitamin D / Q000097:blood*; D014808:Vitamin D Deficiency / Q000503:physiopathology
D010281:Parathyroid Hormone; D014807:Vitamin D