title: Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results.
abstract: We present a clinimetric assessment of the Movement Disorder Society (MDS)-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS). The MDS-UDPRS Task Force revised and expanded the UPDRS using recommendations from a published critique. The MDS-UPDRS has four parts, namely, I: Non-motor Experiences of Daily Living; II: Motor Experiences of Daily Living; III: Motor Examination; IV: Motor Complications. Twenty questions are completed by the patient/caregiver. Item-specific instructions and an appendix of complementary additional scales are provided. Movement disorder specialists and study coordinators administered the UPDRS (55 items) and MDS-UPDRS (65 items) to 877 English speaking (78% non-Latino Caucasian) patients with Parkinson's disease from 39 sites. We compared the two scales using correlative techniques and factor analysis. The MDS-UPDRS showed high internal consistency (Cronbach's alpha = 0.79-0.93 across parts) and correlated with the original UPDRS (rho = 0.96). MDS-UPDRS across-part correlations ranged from 0.22 to 0.66. Reliable factor structures for each part were obtained (comparative fit index > 0.90 for each part), which support the use of sum scores for each part in preference to a total score of all parts. The combined clinimetric results of this study support the validity of the MDS-UPDRS for rating PD.
authors.affiliation: Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA. cgoetz@rush.edu
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Goetz
authors.forename: Barbara C
authors.initials: BC
authors.lastname: Tilley
authors.forename: Stephanie R
authors.initials: SR
authors.lastname: Shaftman
authors.forename: Glenn T
authors.initials: GT
authors.lastname: Stebbins
authors.forename: Stanley
authors.initials: S
authors.lastname: Fahn
authors.forename: Pablo
authors.initials: P
authors.lastname: Martinez-Martin
authors.forename: Werner
authors.initials: W
authors.lastname: Poewe
authors.forename: Cristina
authors.initials: C
authors.lastname: Sampaio
authors.forename: Matthew B
authors.initials: MB
authors.lastname: Stern
authors.forename: Richard
authors.initials: R
authors.lastname: Dodel
authors.forename: Bruno
authors.initials: B
authors.lastname: Dubois
authors.forename: Robert
authors.initials: R
authors.lastname: Holloway
authors.forename: Joseph
authors.initials: J
authors.lastname: Jankovic
authors.forename: Jaime
authors.initials: J
authors.lastname: Kulisevsky
authors.forename: Anthony E
authors.initials: AE
authors.lastname: Lang
authors.forename: Andrew
authors.initials: A
authors.lastname: Lees
authors.forename: Sue
authors.initials: S
authors.lastname: Leurgans
authors.forename: Peter A
authors.initials: PA
authors.lastname: LeWitt
authors.forename: David
authors.initials: D
authors.lastname: Nyenhuis
authors.forename: C Warren
authors.initials: CW
authors.lastname: Olanow
authors.forename: Olivier
authors.initials: O
authors.lastname: Rascol
authors.forename: Anette
authors.initials: A
authors.lastname: Schrag
authors.forename: Jeanne A
authors.initials: JA
authors.lastname: Teresi
authors.forename: Jacobus J
authors.initials: JJ
authors.lastname: van Hilten
authors.forename: Nancy
authors.initials: N
authors.lastname: LaPelle
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004185:Disability Evaluation; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders; D009460:Neurologic Examination / Q000379:methods; D010300:Parkinson Disease / Q000175:diagnosis* / Q000503:physiopathology; D012720:Severity of Illness Index; D012955:Societies, Medical / Q000592:standards