The modified Atkins diet.
In 2003, a case series was published describing the benefits of a less restrictive ketogenic diet (KD) started as an outpatient without a fast and without any restrictions on calories, fluids, or protein. This "Modified Atkins Diet" (MAD) restricts carbohydrates to 10 g/day (15 g/day in adults) while encouraging high fat foods. Now 5 years later, there have been eight prospective and retrospective studies published on this alternative dietary therapy, both in children as well as adults. In these reports, 45 (45%) have had 50-90% seizure reduction, and 28 (28%) >90% seizure reduction, which is remarkably similar to the traditional KD. This review will discuss basics and tips to best provide the MAD, evidence for its efficacy, suggestions about the role of ketosis in dietary treatment efficacy, and its side effect profile. Lastly, the possible future benefits of this treatment for new-onset seizures, adults, neurologic conditions other than epilepsy, and developing countries of the world will be discussed.
Kossoff
Eric H
EH
The Johns Hopkins Hospital, Baltimore, MD 21287, USA. ekossoff@jhmi.edu
Dorward
Jennifer L
JL
D000328:Adult; D002648:Child; D050528:Diet, Carbohydrate-Restricted / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D012640:Seizures / Q000178:diet therapy*