title: Absolute configuration of ketone cyanohydrins by 1H NMR: the special case of polar substituted tertiary alcohols.
abstract: The absolute configuration of ketone cyanohydrins can be assigned from analysis of the 1H NMR spectra of the corresponding (R)- and (S)-MPA ester derivatives and use of delta delta(RS) signs. This is an application of the NMR methodology for stereochemical assignment to tertiary alcohols possessing polar groups as substituents.
authors.affiliation: Departamento de Química Orgánica and Unidad de RMN de Biomoléculas Asociada al CSIC, Universidad de Santiago de Compostela 15782, Santiago de Compostela, Spain.
authors.forename: Iria
authors.initials: I
authors.lastname: Louzao
authors.forename: Rosa
authors.initials: R
authors.lastname: García
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Seco
authors.forename: Emilio
authors.initials: E
authors.lastname: Quiñoá
authors.forename: Ricardo
authors.initials: R
authors.lastname: Riguera
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000592:standards; D008968:Molecular Conformation; D009570:Nitriles / Q000737:chemistry*; D011522:Protons; D012015:Reference Standards; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D007659:Ketones; D009570:Nitriles; D011522:Protons; C430593:cyanohydrin