title: Chromosomal localization of 13 candidate genes for human obesity in the pig genome.
abstract: Thirteen candidate genes for human obesity were selected for cytogenetic mapping by FISH in the pig genome. Among them, 6 genes were assigned to chromosomes for the first time (NR3C1, GNB3, ADRB1, ADRB2, ADRB3 and UCP1). Location of the other 7 genes (INSIG2, LIPIN1, PLIN, NAMPT, ADIPOQ, UCP2 and UCP3), earlier mapped by somatic cell hybridization or with the use of a radiation hybrid panel, was verified (INSIG2) or more precisely described. The genes were assigned to the following chromosomes: INSIG2 to SSC15q12, LIPIN1 to SSC3q26, NR3C1 to SSC2q29, PLIN to SSC7q15, GNB3 to SSC5q21, NAMPT to SSC9q23, ADIPOQ to SSC13q41, ADRB1 to SSC14q28, ADRB2 to SSC2q29, ADRB3 to SSC15q13-14, UCP1 to SSC8q21-22, and both UCP2 and UCP3 to SSC9p24. Most of the genes were located within known QTL for pig fatness traits.
authors.affiliation: Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Poznań, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Nowacka-Woszuk
authors.forename: Izabela
authors.initials: I
authors.lastname: Szczerbal
authors.forename: Honorata
authors.initials: H
authors.lastname: Fijak-Nowak
authors.forename: Marek
authors.initials: M
authors.lastname: Switonski
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D004734:Energy Metabolism; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D050356:Lipid Metabolism / Q000235:genetics; D009765:Obesity / Q000235:genetics; D040641:Quantitative Trait Loci; D034421:Sus scrofa / Q000235:genetics*