title: Cognitive development of singletons conceived by intracytoplasmic sperm injection or in vitro fertilization at age 5 and 10 years.
abstract: OBJECTIVE
  To investigate the cognitive functioning of low-risk singletons born after intracytoplasmic sperm injection (ICSI) or in vitro fertilization (IVF) at the age of 5 or 10 years.
  
  
  METHODS
  Sixty-nine children (35 ICSI, 34 IVF) participated voluntarily in the study that had been approved by the local IRB. Their intellectual functioning was examined by the Kaufmann Assessment Battery for Children.
  
  
  RESULTS
  The IQ of the study group fell in the normal range (mean = 98.2; SD = 12.2). ICSI children (IQ = 94.1, SD = 13.8) had statistically lower intellectual abilities compared to IVF children (IQ = 102.0, SD = 9.1; t = -2.81, p = .005), especially in simultaneous mental processing. 23.5% ICSI children, but only 2.9% IVF children (p = .011) had at least borderline delayed cognitive development.
  
  
  CONCLUSIONS
  Most artificially conceived singletons show a normal cognitive development, however the method of fertilization seems to have an impact on their IQ. ICSI might be associated with the risk for a slightly delayed cognitive development compared to IVF.
authors.affiliation: Department of Child and Adolescent Psychiatry/Psychotherapy, University Ulm, Ulm, Germany. lutz.goldbeck@uniklinik-ulm.de
authors.forename: Lutz
authors.initials: L
authors.lastname: Goldbeck
authors.forename: Friedrich
authors.initials: F
authors.lastname: Gagsteiger
authors.forename: Inge
authors.initials: I
authors.lastname: Mindermann
authors.forename: Stefanie
authors.initials: S
authors.lastname: Ströbele
authors.forename: Yonca
authors.initials: Y
authors.lastname: Izat
mesh_terms: D002648:Child; D002657:Child Development; D002675:Child, Preschool; D003071:Cognition; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology*; D002658:Developmental Disabilities / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods / Q000706:statistics & numerical data*; D005858:Germany / Q000453:epidemiology; D006801:Humans; D007360:Intelligence; D007361:Intelligence Tests / Q000706:statistics & numerical data; D008297:Male; D008606:Mental Processes; D012307:Risk Factors; D020554:Sperm Injections, Intracytoplasmic / Q000706:statistics & numerical data