title: Evaluation of magnetic resonance signal modification induced by hyaluronic acid therapy in chondromalacia patellae: a preliminary study.
abstract: Hyaluronic Acid (HA) is an alternative method for the treatment of osteoarthritis (OA), which acts on pain through a double action: anti-inflammatory and synovial fluid (SF) visco-supplementation. Magnetic Resonance Imaging (MRI), utilizing specific sequences, is a valid method for studying the initial phase of chondral damage. The analysis of the data, obtained through the intensity of values taken by positioning Region of Interest (ROIs) within the lesion, determining the differences before and after treatment with HA injected into the knee. The results obtained after six months and one year from the injection were statistically different in respect to those taken before, immediately and after three months of treatment. MRI represents a valid tool to evaluate the grade of chondromalacia patellae and also to follow the cartilage modification induced by HA therapy.
authors.affiliation: Department of Radiology, Cattolica University, School of Medicine, Policlinico Agostino Gemelli, Rome, Italy. nicola.magarelli@rm.unicatt.it
authors.forename: N
authors.initials: N
authors.lastname: Magarelli
authors.forename: D
authors.initials: D
authors.lastname: Palmieri
authors.forename: L
authors.initials: L
authors.lastname: Ottaviano
authors.forename: M
authors.initials: M
authors.lastname: Savastano
authors.forename: M
authors.initials: M
authors.lastname: Barbato
authors.forename: A
authors.initials: A
authors.lastname: Leone
authors.forename: A
authors.initials: A
authors.lastname: Maggialetti
authors.forename: F P
authors.initials: FP
authors.lastname: Ciampa
authors.forename: L
authors.initials: L
authors.lastname: Bonomo
mesh_terms: D000293:Adolescent; D000328:Adult; D046789:Chondromalacia Patellae / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008297:Male; D011788:Quality of Life; D013997:Time Factors; D055675:Viscosupplements / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D055675:Viscosupplements; D006820:Hyaluronic Acid