title: Magnetic resonance imaging evidence of optic nerve glioma progression into and beyond the optic chiasm.
abstract: Optic nerve glioma has been a topic of great interest and controversy, particularly with respect to its tendency to invade the optic chiasm. This case report demonstrates histologically verified optic nerve glioma in an otherwise healthy 5-year-old girl. MRI revealed sequential prechiasmal, chiasmal, and postchiasmal disease during the untreated course of 18 months. The authors also discuss the results obtained with a specific immunohistochemical technique, the mindbomb homolog 1 (MIB-1) labeling index, and speculate that this information, if known early in the course of disease, might influence early surgical decision-making.
authors.affiliation: Edward S. Harkness Eye Institute, Columbia University Medical Center, New York, New York 10032, USA.
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Walrath
authors.forename: Michael
authors.initials: M
authors.lastname: Engelbert
authors.forename: Michael
authors.initials: M
authors.lastname: Kazim
mesh_terms: D002675:Child, Preschool; D003907:Dexamethasone / Q000008:administration & dosage; D003937:Diagnosis, Differential; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009897:Optic Chiasm / Q000473:pathology*; D020339:Optic Nerve Glioma / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy; D020266:Radiotherapy, Conformal / Q000379:methods; D013997:Time Factors; D014794:Visual Fields
chemical_list: D005938:Glucocorticoids; D003907:Dexamethasone