title: Intake of iodine and perchlorate and excretion in human milk.
abstract: Perchlorate, thiocyanate, and iodine excretion in urine and milk of 13 breastfeeding women was investigated and the results were interpreted by a model of parallel/competitive transport of these species bythe sodium iodide symporter. For each species i, we assumed physiological homeostasis, where i(T,in) equals the corresponding total excretion in urine and milk (i(e,u) + i(e,m)). The fraction of the total excretion that appeared in milk f(I,m) was measured and ranged from 0.394-0.781, 0.018-0.144, and 0.086-0.464 for perchlorate,thiocyanate, and iodine, respectively. The corresponding median values were 0.541, 0.053, and 0.177, respectively. The selectivity factors of perchlorate over iodide transport, and thiocyanate over iodide transport, defined as f(PC,m)/ f(I,m), and f(SCN,m)/ f(I,m), respectively, were 3.14 +/- 1.20 and 0.27 +/- 0.26 while PC(T,in), SCN(T,in), and I(T,in) among individuals varied 4.9, 5.0, and 8.4x, respectively. These transport selectivities are an order of magnitude lower than those indicated by in vitro studies, suggesting that the impact of both these anions on inhibiting iodide transport in milk may have been overestimated in the extant literature. On the other hand, our results showed that 12 of 13 infants did not have an adequate intake of iodine as defined by the Institute of Medicine and 9 out of 13 infants were likely ingesting perchlorate at a level exceeding the reference dose suggested bythe National Academy of Science panel.
authors.affiliation: Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas 76019-0065, USA. Dasgupta@uta.edu
authors.forename: Purnendu K
authors.initials: PK
authors.lastname: Dasgupta
authors.forename: Andrea B
authors.initials: AB
authors.lastname: Kirk
authors.forename: Jason V
authors.initials: JV
authors.lastname: Dyke
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Ohira
mesh_terms: D000328:Adult; D001692:Biological Transport / Q000187:drug effects; D001942:Breast Feeding; D003404:Creatinine / Q000652:urine; D004784:Environmental Monitoring; D005260:Female; D006801:Humans; D007455:Iodine / Q000032:analysis* / Q000652:urine; D008895:Milk, Human / Q000737:chemistry*; D009035:Mothers; D010472:Perchlorates / Q000032:analysis* / Q000652:urine; D018401:Sample Size; D013861:Thiocyanates / Q000494:pharmacology; D014481:United States
chemical_list: D010472:Perchlorates; D013861:Thiocyanates; D007455:Iodine; D003404:Creatinine; C494474:perchlorate