title: Intrauterine insemination with recombinant or urinary human chorionic gonadotropin: A prospective randomized trial.
abstract: OBJECTIVE
  Our aim was to compare the efficacy and safety of recombinant and urinary human chorionic gonadotropin (rhCG and uhCG, respectively) for the induction of follicle maturation in women undergoing intrauterine insemination (IUI).
  
  
  METHODS
  Patients were randomized to receive rhCG or uhCG. IUI was carried out 24 h (day 1) and 48 h (day 2) after hCG administration, except for all cases in which ovulation occurred after 24 h.
  
  
  RESULTS
  The two treatments were comparable in terms of progesterone levels on day 7 and day 12. Pregnancy rates were comparable between the treatment groups. Of the 64 women who received rhCG, 29.7% became pregnant; there were 16.7% clinical pregnancies and 3.1% biochemical pregnancies per started cycle, and an ongoing pregnancy rate of 93.7% was reported. Of the 61 patients who received uhCG, 24.6% became pregnant; there were 15.9% clinical pregnancies and 1.1% biochemical pregnancies per started cycle, and ongoing pregnancy rate was 92.9%. No adverse effects were noted in either group.
  
  
  CONCLUSIONS
  The recombinant products can be effectively used instead of urinary products; moreover, apart from the equivalent efficacy in ovulation induction and safety described in this study, it is necessary to consider the advantages provided by the recombinant form.
authors.affiliation: Department of Gynaecology, Obstetrics and Neonatology, Gynaecology and Obstetric Unit A, University of Bari, Bari, Italy. milalorusso@yahoo.it
authors.forename: Filomenamila
authors.initials: F
authors.lastname: Lorusso
authors.forename: Marcella
authors.initials: M
authors.lastname: Palmisano
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Serratì
authors.forename: Emma
authors.initials: E
authors.lastname: Bassi
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Lamanna
authors.forename: Margherita
authors.initials: M
authors.lastname: Vacca
authors.forename: Raffaella
authors.initials: R
authors.lastname: Depalo
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy*; D007315:Insemination, Artificial; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D011994:Recombinant Proteins / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D006063:Chorionic Gonadotropin; D011994:Recombinant Proteins