Trends in pediatric sickle cell disease-related mortality in the United States, 1983-2002.
OBJECTIVE
To analyze trends in sickle cell disease (SCD)-related mortality among black children during 1983-2002.


METHODS
Using the multiple-cause mortality files compiled by the Centers for Disease Control and Prevention's National Center for Health Statistics, we analyzed deaths among children classified as black who were age 14 years and younger and had SCD identified on their death certificates.


RESULTS
Relative to the rate for 1983-1986, the SCD mortality rate for 1999-2002 decreased by 68% (95% confidence interval [CI]=58% to 75%) at age 0 to 3 years, by 39% (95% CI=16% to 56%) at age 4 to 9 years, and by 24% (95% CI= -9% to 47%) at age 10 to 14 years. For the most recent period studied, a significant (42%) reduction in mortality at age 0 to 3 years was seen between 1995-1998 and 1999-2002, with essentially no reduction in SCD mortality at older ages.


CONCLUSIONS
Recent decreases in SCD mortality in black children under age 4 years coincided with the introduction of the 7-valent pneumococcal conjugate vaccine in 2000, although temporal association is not evidence of causation. The lack of significant recent reduction in SCD mortality in older children indicates the need for new treatment approaches.
Yanni
Emad
E
National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. eyanni@cdc.gov
Grosse
Scott D
SD
Yang
QuanHe
Q
Olney
Richard S
RS
D000293:Adolescent; D001741:Black or African American / Q000706:statistics & numerical data; D017677:Age Distribution; D000755:Anemia, Sickle Cell / Q000401:mortality* / Q000517:prevention & control; D002423:Cause of Death; D002648:Child; D002675:Child, Preschool; D003141:Communicable Diseases / Q000401:mortality; D005260:Female; D018073:Haemophilus Vaccines; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D032541:Mass Vaccination; D009026:Mortality / Q000639:trends; D015997:Neonatal Screening; D022242:Pneumococcal Vaccines; D014481:United States / Q000453:epidemiology
D018073:Haemophilus Vaccines; D022242:Pneumococcal Vaccines