Hypertriglyceridaemia is associated with an increased likelihood of albuminuria in extreme duration (> 50 years) Type 1 diabetes.
OBJECTIVE
To explore the association between dyslipidaemia and albuminuria at the extreme of diabetes duration.


METHODS
Data and samples were collected from 400 patients with extreme duration (> 50 years) of Type 1 diabetes in the UK (Golden Years Cohort). Urinary albumin-creatinine ratio (ACR), glycated haemoglobin (HbA(1c)), creatinine, non-fasting triglycerides, total cholesterol, high-density lipoprotein- and low-density lipoprotein-cholesterol were analysed in all patients.


RESULTS
Thirty-six percent of patients had albuminuria (micro- or macroalbuminuria). After adjusting for age, gender, HbA(1c), disease duration and presence of macrovascular disease, hypertriglyceridaemia was more likely to be associated with the presence of albuminuria.


CONCLUSIONS
High triglycerides may be a potential risk factor for progression of diabetic nephropathy at the extreme of diabetes duration, but the benefit of targeting this aggressively remains to be evaluated further.
Daousi
C
C
Diabetes & Endocrinology Clinical Research Group, University Hospital Aintree, Clinical Sciences Centre, Liverpool, UK. cdaousi@liverpool.ac.uk
Bain
S C
SC
Barnett
A H
AH
Gill
G V
GV
D000368:Aged; D000419:Albuminuria / Q000097:blood*; D016009:Chi-Square Distribution; D015331:Cohort Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D018450:Disease Progression; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric; D013997:Time Factors