title: Leiomyosarcoma of the prostate: case report and review of 54 previously published cases.
abstract: Prostate leiomyosarcoma is an extremely rare and highly aggressive neoplasm that accounts for less than 0.1% of primary prostate malignancies. We present a patient with primary leiomyosarcoma of the prostate and review 54 cases reported in the literature to discuss the clinical, diagnostic and therapeutic aspects of this uncommon tumor. Median survival was estimated at 17 months (95% C.I. 20.7-43.7 months) and the 1-, 3-, and 5-year actuarial survival rates were 68%, 34%, and 26%, respectively. The only factors predictive of long-term survival were negative surgical margins and absence of metastatic disease at presentation. A multidisciplinary approach is necessary for appropriate management of this dire entity.
authors.affiliation: Department of Pathology, Aeghion General Hospital, 25100 Aeghion, Greece.
authors.forename: Gerasimos P
authors.initials: GP
authors.lastname: Vandoros
authors.forename: Theodoros
authors.initials: T
authors.lastname: Manolidis
authors.forename: Michalis V
authors.initials: MV
authors.lastname: Karamouzis
authors.forename: Maria
authors.initials: M
authors.lastname: Gkermpesi
authors.forename: Maria
authors.initials: M
authors.lastname: Lambropoulou
authors.forename: Athanasios G
authors.initials: AG
authors.lastname: Papatsoris
authors.forename: Ioannis
authors.initials: I
authors.lastname: Zachos
authors.forename: Panagiotis A
authors.initials: PA
authors.lastname: Konstantinopoulos