Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results.
We present a clinimetric assessment of the Movement Disorder Society (MDS)-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS). The MDS-UDPRS Task Force revised and expanded the UPDRS using recommendations from a published critique. The MDS-UPDRS has four parts, namely, I: Non-motor Experiences of Daily Living; II: Motor Experiences of Daily Living; III: Motor Examination; IV: Motor Complications. Twenty questions are completed by the patient/caregiver. Item-specific instructions and an appendix of complementary additional scales are provided. Movement disorder specialists and study coordinators administered the UPDRS (55 items) and MDS-UPDRS (65 items) to 877 English speaking (78% non-Latino Caucasian) patients with Parkinson's disease from 39 sites. We compared the two scales using correlative techniques and factor analysis. The MDS-UPDRS showed high internal consistency (Cronbach's alpha = 0.79-0.93 across parts) and correlated with the original UPDRS (rho = 0.96). MDS-UPDRS across-part correlations ranged from 0.22 to 0.66. Reliable factor structures for each part were obtained (comparative fit index > 0.90 for each part), which support the use of sum scores for each part in preference to a total score of all parts. The combined clinimetric results of this study support the validity of the MDS-UPDRS for rating PD.
Goetz
Christopher G
CG
Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA. cgoetz@rush.edu
Tilley
Barbara C
BC
Shaftman
Stephanie R
SR
Stebbins
Glenn T
GT
Fahn
Stanley
S
Martinez-Martin
Pablo
P
Poewe
Werner
W
Sampaio
Cristina
C
Stern
Matthew B
MB
Dodel
Richard
R
Dubois
Bruno
B
Holloway
Robert
R
Jankovic
Joseph
J
Kulisevsky
Jaime
J
Lang
Anthony E
AE
Lees
Andrew
A
Leurgans
Sue
S
LeWitt
Peter A
PA
Nyenhuis
David
D
Olanow
C Warren
CW
Rascol
Olivier
O
Schrag
Anette
A
Teresi
Jeanne A
JA
van Hilten
Jacobus J
JJ
LaPelle
Nancy
N
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004185:Disability Evaluation; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders; D009460:Neurologic Examination / Q000379:methods; D010300:Parkinson Disease / Q000175:diagnosis* / Q000503:physiopathology; D012720:Severity of Illness Index; D012955:Societies, Medical / Q000592:standards