[Influence of amino acids alimentary on contracts ability in 13-adreno- and M-cholinoreactivity of smooth muscles].
It was studied the influence of 20 amino acids on beta-adreno- and M-cholinoreactivity of longitudinal strips (n = 268) of rat uterus horn (n = 46) with the help of adrenaline (10(-8) g/ml) and acetilcholine (10(-6) g/Ml) accordingly. It is shown, that 3 amino acids from 20, including L-histidine (3 x 10(-8) - 3 x 10(-5) g/ml), L-triptophan (10(-8) - 10(-5)) and D-, L-tyrosine (2 x 10(-8) - 2 x 10(-5)), not changing M-cholinoreactivity of uterus smooth muscles, everyone or complexly essentially raised their beta-adrenoreactivity, i.e. expressed their beta-adrenosensibilisatory activity. It allows to consider that this amino acids are possible components of endogenic sensibilisator of beta-adrenocepters. It is discussed the question about using this amino acids in a dietary meal and complex therapy at insufficiency of beta-adrenergic influences on visceral organs.
Sizova
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Tsirkin
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Tumanova
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D000109:Acetylcholine / Q000494:pharmacology*; D000322:Adrenergic Agonists / Q000494:pharmacology*; D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D018678:Cholinergic Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D009119:Muscle Contraction / Q000187:drug effects*; D009215:Myometrium / Q000378:metabolism*; D009924:Organ Culture Techniques; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D011950:Receptors, Cholinergic / Q000378:metabolism
D000322:Adrenergic Agonists; D000596:Amino Acids; D018678:Cholinergic Agents; D011943:Receptors, Adrenergic, beta; D011950:Receptors, Cholinergic; D000109:Acetylcholine; D004837:Epinephrine