title: Growth conditions regulate the requirements for Caulobacter chromosome segregation.
abstract: Growth environments are important metabolic and developmental regulators. Here we demonstrate a growth environment-dependent effect on Caulobacter chromosome segregation of a small-molecule inhibitor of the MreB bacterial actin cytoskeleton. Our results also implicate ParAB as important segregation determinants, suggesting that multiple distinct mechanisms can mediate Caulobacter chromosome segregation and that their relative contributions can be environmentally regulated.
authors.affiliation: Department of Molecular Biology, Princeton University, Washington Rd., Princeton, NJ 08544, USA.
authors.forename: Conrad W
authors.initials: CW
authors.lastname: Shebelut
authors.forename: Rasmus B
authors.initials: RB
authors.lastname: Jensen
authors.forename: Zemer
authors.initials: Z
authors.lastname: Gitai
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology; D016934:Caulobacter / Q000187:drug effects / Q000235:genetics*; D020090:Chromosome Segregation / Q000187:drug effects / Q000235:genetics*; D002876:Chromosomes, Bacterial / Q000235:genetics*; D013890:Thiourea / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D001426:Bacterial Proteins; C015799:2,6-dichlorobenzylthiopseudourea; D013890:Thiourea