Characteristics of transplanted mouse myeloproliferative disease developed after repeated injections of granulocytic colony-stimulating factor.
Transplanted myeloproliferative disease developed in mice against the background of repeated injections of granulocytic CSF was characterized using morphological and molecular biological methods. It was demonstrated that transplanted myeloproliferative disease had a non-viral nature and is probably induced by repeated injections of granulocytic CSF. Tumor cells actively populate the liver of sick animals, which leads to their rapid death. Expression of Myc, Abl, G-CSF, and MPO genes is enhanced, which is typical of myeloid neoplastic transformation.
Bigildeev
A E
AE
Laboratory of Hemopoiesis Physiology, Hematological Research Center, Russian Academy of Medical Sciences, Moscow.
Sats
N V
NV
Grishchuk
A L
AL
Nifontova
I N
IN
Svinareva
D A
DA
Drize
N J
NJ
D000818:Animals; D001773:Blood Cells / Q000166:cytology / Q000378:metabolism; D001854:Bone Marrow Cells / Q000502:physiology; D005260:Female; D005786:Gene Expression Regulation; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000009:adverse effects*; D008099:Liver / Q000166:cytology / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009196:Myeloproliferative Disorders / Q000209:etiology* / Q000401:mortality
D016179:Granulocyte Colony-Stimulating Factor