title: Application of ynamides in the synthesis of 2-amidoindoles.
abstract: A Pd-catalyzed, one-pot, two-step synthesis of 2-amidoindoles from ynamides and o-iodoanilines is reported. A key highlight of this sequence is that after the Sonogashira reaction, intramolecular cyclization to the indole occurs spontaneously without activation of the alkyne.
authors.affiliation: Center for Insoluble Protein Structures (inSPIN), Department of Chemistry and the Interdisciplinary Nanoscience Center, Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark.
authors.forename: Karin
authors.initials: K
authors.lastname: Dooleweerdt
authors.forename: Thomas
authors.initials: T
authors.lastname: Ruhland
authors.forename: Troels
authors.initials: T
authors.lastname: Skrydstrup
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000577:Amides / Q000737:chemistry*; D000814:Aniline Compounds / Q000737:chemistry; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D008024:Ligands; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D000577:Amides; D000814:Aniline Compounds; D007211:Indoles; D008024:Ligands; D010165:Palladium; C075715:3-iodoaniline