title: Asymmetric, catalytic, and direct self-aldol reaction of acetaldehyde catalyzed by diarylprolinol.
abstract: An asymmetric, catalytic, and direct self-aldol reaction of acetaldehyde was catalyzed by diarylprolinol in NMP, affording the trimer acetal, which was generated by the reaction of the self-aldol product with another acetaldehyde molecule in a moderate yield with good enantioselectivity. Acetal is the synthetic equivalent of the self-aldol product, which can be converted into other synthetically useful compounds in one pot without compromising the enantioselectivity.
authors.affiliation: Department of Industrial Chemistry, Faculty of Engineering, and Research Institute for Science and Technology, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan. hayashi@ci.kagu.tus.ac.jp
authors.forename: Yujiro
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Sampak
authors.initials: S
authors.lastname: Samanta
authors.forename: Takahiko
authors.initials: T
authors.lastname: Itoh
authors.forename: Hayato
authors.initials: H
authors.lastname: Ishikawa