Dynamic relationships between catecholamine-induced shifts of pressure and blood flow in pulmonary artery.
Experiments on cats showed that catecholamines produced maximum changes in pulmonary artery blood pressure during 12-16 sec postinjection, while blood flow in this artery attained maximum only to 40 sec postinjection, i.e. changes in blood flow attained maximum and ended later than blood pressure shifts. Intravenous epinephrine produced bidirectional changes in blood pressure, while norepinephrine always elevated blood pressure in the pulmonary artery; pulmonary circulation increased after injection of both catecholamines.
Tkachenko
B I
BI
Department of Visceral Systems Physiology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg.
Evlakhov
V I
VI
Poyassov
I Z
IZ
D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects*; D002395:Catecholamines / Q000494:pharmacology*; D002415:Cats; D004837:Epinephrine / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D011651:Pulmonary Artery / Q000187:drug effects*; D013566:Sympathomimetics / Q000494:pharmacology
D002395:Catecholamines; D013566:Sympathomimetics; D009638:Norepinephrine; D004837:Epinephrine