A liposomal delivery vehicle for the anticancer agent gossypol.
BACKGROUND
Gossypol has recently been identified as a potential anticancer agent. In this study, a novel liposomal formulation is evaluated for delivery of gossypol.


METHODS
Gossypol was incorporated into liposomes. The liposomes were characterized for physical and chemical properties and for in vitro cytotoxicity.


RESULTS
Gossypol was stably encapsulated in these liposomes and exhibited cytotoxicity towards cancer cells.


CONCLUSIONS
Liposomes can be used effectively as gossypol carriers.
Zhai
Guangxi
G
College of Pharmacy, Shandong University, Jinan 250012, P. R. China.
Wu
Jun
J
Zhao
Xiaobin
X
Yu
Bo
B
Li
Hong
H
Lu
Yanhui
Y
Ye
Weiping
W
Lin
Young C
YC
Lee
Robert J
RJ
D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D045744:Cell Line, Tumor; D006072:Gossypol / Q000008:administration & dosage* / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D007624:KB Cells; D008081:Liposomes / Q000008:administration & dosage* / Q000737:chemistry; D010743:Phospholipids / Q000008:administration & dosage / Q000737:chemistry
D000970:Antineoplastic Agents; D008081:Liposomes; D010743:Phospholipids; D006072:Gossypol