title: Increasing adiposity in normal ovulatory women affects adipocytokine expression in subcutaneous and visceral abdominal fat.
abstract: OBJECTIVE
  To determine which adipocytokines are differentially expressed as a function of body mass index (BMI), to compare expression of adipocytokines in abdominal subcutaneous and omental fat, and to correlate these findings with serum levels, BMI, and parameters of insulin resistance.
  
  
  METHODS
  Serum and subcutaneous (sc) and omental (om) tissue were obtained from lean and obese ovulatory women undergoing gynecologic surgery. We determined adipocytokine expression in sc versus om abdominal fat and related this to increasing BMI.
  
  
  RESULTS
  Serum leptin was higher and adiponectin lower in overweight subjects. Adipocytokines had higher expression in sc abdominal versus om adipose tissue with the most significant difference observed for leptin (P=0.01). As BMI increased, sc leptin expression increased and adiponectin expression decreased. The leptin/adiponectin ratio correlated significantly with BMI (R=0.84, P=0.0001).
  
  
  CONCLUSIONS
  Increased adipocytokine expression correlates with BMI. Abdominal sc tissue has greater adipocytokine expression overall. The serum leptin/adiponectin ratio is highly correlated with BMI. These data may help in our understanding of how obesity affects women in a variety of ways.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Columbia University Medical Center, New York, NY 10032, USA. pratibhasharma.md@gmail.com
authors.forename: Pratibhasri A
authors.initials: PA
authors.lastname: Vardhana
authors.forename: Cary
authors.initials: C
authors.lastname: Dicken
authors.forename: Drew V
authors.initials: DV
authors.lastname: Tortoriello
authors.forename: Michelene
authors.initials: M
authors.lastname: Chu
authors.forename: Enrico
authors.initials: E
authors.lastname: Carmina
authors.forename: Rogerio A
authors.initials: RA
authors.lastname: Lobo
mesh_terms: D054392:Adipokines / Q000378:metabolism*; D050154:Adiposity; D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D050152:Intra-Abdominal Fat / Q000378:metabolism*; D010060:Ovulation; D050507:Subcutaneous Fat, Abdominal / Q000378:metabolism*
chemical_list: D054392:Adipokines