title: Pressure support ventilation attenuates ventilator-induced protein modifications in the diaphragm.
abstract: Common medical conditions that require mechanical ventilation include chronic obstructive lung disease, acute lung injury, sepsis, heart failure, drug overdose, neuromuscular disorders, and surgery. Although mechanical ventilation can be a life saving measure, prolonged mechanical ventilation can also present clinical problems. Indeed, numerous well-controlled animal studies have demonstrated that prolonged mechanical ventilation results in diaphragmatic weakness due to both atrophy and contractile dysfunction. Importantly, a recent clinical investigation has confirmed that prolonged mechanical ventilation results in atrophy of the human diaphragm. This mechanical ventilation-induced diaphragmatic weakness is important because the most frequent cause of weaning difficulty is respiratory muscle failure due to inspiratory muscle weakness and/or a decline in inspiratory muscle endurance. Therefore, developing methods to protect against mechanical ventilation-induced diaphragmatic weakness is important.
authors.affiliation: Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32608, USA. spowers@hhp.ufl.edu
authors.forename: Scott K
authors.initials: SK
authors.lastname: Powers
authors.forename: Marc
authors.initials: M
authors.lastname: DeCramer
authors.forename: Ghislaine
authors.initials: G
authors.lastname: Gayan-Ramirez
authors.forename: Sanford
authors.initials: S
authors.lastname: Levine
mesh_terms: D016638:Critical Illness; D003964:Diaphragm / Q000503:physiopathology*; D006801:Humans; D009133:Muscular Atrophy / Q000209:etiology / Q000503:physiopathology; D009210:Myofibrils / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D012121:Respiration, Artificial / Q000009:adverse effects*; D012133:Respiratory Paralysis / Q000209:etiology* / Q000503:physiopathology
chemical_list: D011506:Proteins