Is it time to re-evaluate our use of acetaminophen in certain sub-groups of pregnant women?
New insight into the pharmacological mechanisms of acetaminophen raises questions about its possible safety in certain subgroups of pregnant women. Recent focus on acetaminophen's ability to modulate prostaglandin synthesis may require modification of its ubiquitous use in pregnancy. Further basic science, epidemiologic and clinical studies are required to explore the interaction of acetaminophen with placentation leading to vascular pathologic conditions during pregnancy.
Zelop
Carolyn M
CM
Saint Francis Hospital and Medical Centre, Hartford, Connecticut 06105, USA. czelop@stfranciscare.org
D000082:Acetaminophen / Q000009:adverse effects; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects; D000075202:Contraindications; D011464:Epoprostenol / Q000378:metabolism; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000209:etiology*; D011247:Pregnancy
D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen; D011464:Epoprostenol