Long-term effects of melatonin after intracerebral hemorrhage in rats.
Free radical scavengers have been shown to improve short-term outcome after intracerebral hemorrhage (ICH). The purpose of this study was to evaluate whether melatonin (a potent free radical scavenger and an indirect antioxidant) can improve short- and/or long-term neurological function after ICH, which was induced by collagenase injection into the striatum of adult rats. Melatonin (15 mg/kg) was administered by intraperitoneal injection at 1, 24, 48, and 72 h. Neurological and behavioral testing was performed at several time points from 1 day to 8 weeks post-ICH. Neurological and behavioral deficits were observed in ICH rats at all time points, but the melatonin treatment regimen did not improve performance or level of brain injury.
Hartman
R E
RE
Department of Psychology, Loma Linda University, 11130 Anderson St. 119, Loma Linda, CA 92354, USA. behavioralneuroscience@gmail.com
Rojas
H A
HA
Lekic
T
T
Ayer
R
R
Lee
S
S
Jadhav
V
V
Titova
E
E
Tang
J
J
Zhang
J H
JH
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects; D020520:Brain Infarction / Q000188:drug therapy / Q000209:etiology; D002543:Cerebral Hemorrhage / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D017364:Collagenases; D003342:Corpus Striatum / Q000187:drug effects; D004195:Disease Models, Animal; D005106:Exploratory Behavior / Q000187:drug effects; D008297:Male; D008550:Melatonin / Q000627:therapeutic use*; D009043:Motor Activity / Q000187:drug effects; D009460:Neurologic Examination; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D000975:Antioxidants; D017364:Collagenases; D008550:Melatonin