title: [Persistent diarrhoea, hypotension, polyneuropathy].
abstract: We present a case report of a 59-year-old man with a history of arterial hypertension and excision of malignant melanoma. He was admitted to the hospital because of two months history of diarrhoea, weight loss and circulatory collapse. In addition, the patient suffered from marked vegetative instability with symptomatic hypotension, polyneuropathy and progression of renal insufficiency, without proteinuria. Complex examination did not reveal neoplasms, endocrine, autoimmune, infectious or neurodegenerative disorders. A serial biopsy of colon failed to provide a clue to the diagnosis. However, AA amyloidosis was found on the kidney biopsy. Neither chronic inflammation nor malignancy was revealed and, hence, no causal treatment could have been established. The patient died from multiple organ failure. The autopsy confirmed systemic AA amyloidosis. The triad consisting ofdiarrhoea, polyneuropathy and hypotension should rise the suspicion on amyloidosis.
authors.affiliation: I Interní Klinika Lékarské Fakulty UK a FN Plzen.
authors.forename: R
authors.initials: R
authors.lastname: Sýkora
authors.forename: J
authors.initials: J
authors.lastname: Radej
authors.forename: I
authors.initials: I
authors.lastname: Novák
authors.forename: A
authors.initials: A
authors.lastname: Krouzecký
authors.forename: J
authors.initials: J
authors.lastname: Mares
authors.forename: I
authors.initials: I
authors.lastname: Irová
authors.forename: S
authors.initials: S
authors.lastname: Hadravská
authors.forename: J
authors.initials: J
authors.lastname: Chvojka
authors.forename: T
authors.initials: T
authors.lastname: Karvunidis
authors.forename: T
authors.initials: T
authors.lastname: Manáková
authors.forename: M
authors.initials: M
authors.lastname: Matejovic
mesh_terms: D000686:Amyloidosis / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D003967:Diarrhea / Q000150:complications*; D005260:Female; D006801:Humans; D007022:Hypotension / Q000150:complications*; D008875:Middle Aged; D011115:Polyneuropathies / Q000150:complications*