title: A dynamic view of the spread and intracellular distribution of Salmonella enterica.
abstract: The events that determine the dynamics of proliferation, spread and distribution of microbial pathogens within their hosts are surprisingly heterogeneous and poorly understood. We contend that understanding these phenomena at a sophisticated level with the help of mathematical models is a prerequisite for the development of truly novel, targeted preventative measures and drug regimes. We describe here recent studies of Salmonella enterica infections in mice which suggest that bacteria resist the antimicrobial environment inside host cells and spread to new sites, where infection foci develop, and thus avoid local escalation of the adaptive immune response. We further describe implications for our understanding of the pathogenic mechanism inside the host.
authors.affiliation: Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom. pm274@cam.ac.uk
authors.forename: Pietro
authors.initials: P
authors.lastname: Mastroeni
authors.forename: Andrew
authors.initials: A
authors.lastname: Grant
authors.forename: Olivier
authors.initials: O
authors.lastname: Restif
authors.forename: Duncan
authors.initials: D
authors.lastname: Maskell
mesh_terms: D000818:Animals; D006801:Humans; D051379:Mice; D012480:Salmonella Infections / Q000382:microbiology*; D012481:Salmonella Infections, Animal / Q000382:microbiology*; D019779:Salmonella enterica / Q000254:growth & development / Q000276:immunology / Q000472:pathogenicity / Q000502:physiology*