title: Prolonged Activated Partial Thromboplastin Time in Systemic Lupus Erythematosus Overlap Syndrome: Fatal Bleeding Due to Factor VIII Inhibitor.
abstract: A prolonged partial thromboplastin time in a patient with systemic lupus erythematosus usually is due to a lupus anticoagulant. Antiphospholipid antibodies may be associated with thrombosis. We describe a patient with an overlap syndrome between systemic lupus erythematosus and mixed connective tissue disease who presented with a prolonged partial thromboplastin time due to a high titer of antibodies to factor VIII (acquired hemophilia). The clinical course resulted in a fatal hemorrhage, illustrating the importance of prompt distinction between lupus anticoagulants and clotting factor inhibitors.
authors.affiliation: Division of Rheumatology, Department of Medicine, UMDNJ-RWJMS at Camden and Cooper Hospital, University Medical Center.
authors.forename: C R
authors.initials: CR
authors.lastname: Oʼconnor
authors.forename: A J
authors.initials: AJ
authors.lastname: Reginato
authors.forename: J H
authors.initials: JH
authors.lastname: Ing
authors.forename: J A
authors.initials: JA
authors.lastname: Keech