A new role for cisplatin: probing ribosomal RNA structure.
In this study, cisplatin, the well-known anticancer drug, was used to probe accessible purine residues in E. coli 16S ribosomal RNA (rRNA), free or in the context of 30S subunits or 70S ribosomes, both in vitro and in vivo.
Rijal
Keshab
K
Department of Chemistry, Wayne State University, Detroit, Michigan, 48202, USA.
Chow
Christine S
CS
D000970:Antineoplastic Agents / Q000737:chemistry*; D001345:Autoradiography; D002945:Cisplatin / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004058:Diffusion; D006147:Guanine / Q000737:chemistry; D008958:Models, Molecular; D012335:RNA, Ribosomal / Q000737:chemistry*; D012336:RNA, Ribosomal, 16S / Q000737:chemistry; D015183:Restriction Mapping; D012270:Ribosomes / Q000737:chemistry
D000970:Antineoplastic Agents; D012335:RNA, Ribosomal; D012336:RNA, Ribosomal, 16S; D006147:Guanine; D002945:Cisplatin