[The change of cyclooxygenase-2 and inducible nitric oxide synthase in the gastric mucosa one year after eradication of Helicobacter pylori].
OBJECTIVE
The cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), the proteins that have the role in the gastric carcinogenesis, are stimulated by H. pylori infection in the gastric mucosa. The aim of this study was to evaluate the expression of COX-2 and iNOS proteins one year after the eradication of H. pylori.


METHODS
Gastric antral mucosa from fifty eight patients with chronic gastritis who were all infected with H. pylori was examined for the expression of COX-2 and iNOS proteins before and one year after the eradication of H. pylori by immunohistochemical stain.


RESULTS
COX-2 and iNOS proteins were expressed in the epithelial cells and interstitial inflammatory cells of gastric mucosa. Percent expressions of COX-2 and iNOS were significantly decreased one year after the eradication in the patients with cured infection, but not in those having persistent H. pylori. COX-2 and iNOS expressions were well correlated with H. pylori density, acute and chronic inflammation of gastric mucosa.


CONCLUSIONS
The eradication of H. pylori can decrease the expression of COX-2 and iNOS in the gastric mucosa in long-term period. This seems to be due to the removal of H. pylori itself and related regression of gastric inflammation.
Kim
Sung Soo
SS
Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
Sung
Young Jick
YJ
Park
Min Kyoung
MK
Lim
Chang Hoon
CH
Yang
Hong Jun
HJ
Kim
Tae Ho
TH
Kim
Chang Whan
CW
Kim
Jin Il
JI
Han
Sok Won
SW
Chung
In Sik
IS
D051546:Cyclooxygenase 2 / Q000276:immunology / Q000378:metabolism*; D004359:Drug Therapy, Combination; D005753:Gastric Mucosa / Q000201:enzymology*; D016481:Helicobacter Infections / Q000188:drug therapy; D016480:Helicobacter pylori; D006801:Humans; D052247:Nitric Oxide Synthase Type II / Q000276:immunology / Q000378:metabolism*; D013997:Time Factors
C496319:NOS2 protein, human; D052247:Nitric Oxide Synthase Type II; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human