title: [Pathophysiology of invasive fungal infection in diabetic patients].
abstract: It has been known that diabetes mellitus impairs functioning of neutrophil, macrophage, cellular immunity, humoral immunity, and iron metabolism. In addition to them, diabetes-related angiopathy leads a patient to being at high-risk individual for several kinds of infectious diseases. Therefore, diabetes has been accepted as one of the important risk factors for invasive fungal infection. From the viewpoint of pathology, the present review describes both pathophysiology of immunosuppression induced by diabetes and histopathological characteristics of typical forms in invasive fungal infection when it occurred as an opportunistic infection; those are candidiasis, aspergillosis, and cryptococcosis. We wish to draw that pathophysiological explanation still remains obscuring of relationship between diabetes and invasive fungal infection.
authors.affiliation: Department of Surgical Pathology, Toho University School of Medicine.
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Okubo
authors.forename: Haruo
authors.initials: H
authors.lastname: Nakayama
authors.forename: Chikako
authors.initials: C
authors.lastname: Hasegawa
authors.forename: Aki
authors.initials: A
authors.lastname: Mitsuda
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Hatori
authors.forename: Kayoko
authors.initials: K
authors.lastname: Tanikawa
authors.forename: Minoru
authors.initials: M
authors.lastname: Shinozaki
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Shibuya
mesh_terms: D002177:Candidiasis / Q000150:complications* / Q000473:pathology*; D020314:Central Nervous System Fungal Infections / Q000150:complications / Q000473:pathology; D003453:Cryptococcosis / Q000150:complications* / Q000473:pathology*; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000276:immunology; D006801:Humans; D016867:Immunocompromised Host; D055744:Invasive Pulmonary Aspergillosis / Q000150:complications / Q000473:pathology; D008172:Lung Diseases, Fungal / Q000150:complications* / Q000473:pathology*; D009894:Opportunistic Infections / Q000150:complications; D012307:Risk Factors