title: Molecular imaging reveals unique degenerative changes in experimental glaucoma.
abstract: Experimentally induced changes in the central visual pathway were studied by using positron emission tomography in monkeys with unilateral hypertension glaucoma. In 2-[18F]fluoro-2-deoxy-glucose studies, monocular visual stimulation of the affected eye yielded significantly reduced neural responses in the occipital visuocortical areas. The response reduction was limited to the visual cortex ipsilateral to the affected eye, indicating the unique vulnerability of ipsilateral visual cortex in experimental unilateral glaucoma. In addition, in [11C]PK11195 positron emission tomography and immunohistochemical studies, selective accumulation of activated microglia, a sign of neural degeneration, was found bilaterally in lateral geniculate nuclei. The present findings establish the usefulness of noninvasive molecular imaging for early diagnosis of glaucoma by providing a sharper surrogate end point for an early phase of glaucoma.
authors.affiliation: Department of Systems Life Engineering, Maebashi Institute of Technology, Maebashi-shi, Gunma, Japan. imamurak@maebashi-it.ac.jp
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Imamura
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Onoe
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Shimazawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nozaki
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Wada
authors.forename: Koichi
authors.initials: K
authors.lastname: Kato
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakajima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mizuma
authors.forename: Kayo
authors.initials: K
authors.lastname: Onoe
authors.forename: Takazumi
authors.initials: T
authors.lastname: Taniguchi
authors.forename: Masaaki
authors.initials: M
authors.lastname: Sasaoka
authors.forename: Hideaki
authors.initials: H
authors.lastname: Hara
authors.forename: Shigeru
authors.initials: S
authors.lastname: Tanaka
authors.forename: Makoto
authors.initials: M
authors.lastname: Araie
authors.forename: Yasuyoshi
authors.initials: Y
authors.lastname: Watanabe
mesh_terms: D000818:Animals; D002250:Carbon Radioisotopes / Q000378:metabolism; D005462:Fluorine Radioisotopes / Q000378:metabolism; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism; D005829:Geniculate Bodies / Q000000981:diagnostic imaging* / Q000473:pathology; D005901:Glaucoma / Q000000981:diagnostic imaging* / Q000473:pathology; D000882:Haplorhini; D007150:Immunohistochemistry; D007546:Isoquinolines / Q000378:metabolism; D017628:Microglia / Q000473:pathology; D009410:Nerve Degeneration / Q000000981:diagnostic imaging* / Q000473:pathology; D009778:Occipital Lobe / Q000000981:diagnostic imaging* / Q000473:pathology; D019721:Ophthalmoscopes; D049268:Positron-Emission Tomography; D014793:Visual Cortex / Q000000981:diagnostic imaging
chemical_list: D002250:Carbon Radioisotopes; D005462:Fluorine Radioisotopes; D007546:Isoquinolines; D019788:Fluorodeoxyglucose F18; C037850:PK 11195