Bcl-2 proteins and apoptosis: choose your partner.
The Bcl-2 family protein Bax is a key effector of apoptosis. Lovell et al. (2008) now describe the reconstitution and regulation in liposomes of tBid-mediated membrane penetration and oligomerization of Bax. These and other recent studies shed new light on the control of permeabilization of the mitochondrial outer membrane during apoptosis.
Shore
Gordon C
GC
Department of Biochemistry and Goodman Cancer Center, McGill University, Montreal QCH3G1Y6, Canada. gordon.shore@mcgill.ca
Nguyen
Mai
M
D000818:Animals; D017209:Apoptosis; D008081:Liposomes / Q000378:metabolism; D051336:Mitochondrial Membranes / Q000378:metabolism*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*
D008081:Liposomes; D019253:Proto-Oncogene Proteins c-bcl-2