Iron homeostasis and eye disease.
BACKGROUND
Iron is necessary for life, but excess iron can be toxic to tissues. Iron is thought to damage tissues primarily by generating oxygen free radicals through the Fenton reaction.


METHODS
We present an overview of the evidence supporting iron's potential contribution to a broad range of eye disease using an anatomical approach.


RESULTS
Iron can be visualized in the cornea as iron lines in the normal aging cornea as well as in diseases like keratoconus and pterygium. In the lens, we present the evidence for the role of oxidative damage in cataractogenesis. Also, we review the evidence that iron may play a role in the pathogenesis of the retinal disease age-related macular degeneration. Although currently there is no direct link between excess iron and development of optic neuropathies, ferrous iron's ability to form highly reactive oxygen species may play a role in optic nerve pathology. Lastly, we discuss recent advances in prevention and therapeutics for eye disease with antioxidants and iron chelators.


CONCLUSIONS
Iron homeostasis is important for ocular health.
Loh
Allison
A
F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Hadziahmetovic
Majda
M
Dunaief
Joshua L
JL
D000975:Antioxidants / Q000627:therapeutic use; D002386:Cataract / Q000209:etiology; D003316:Corneal Diseases / Q000139:chemically induced / Q000209:etiology; D005128:Eye Diseases / Q000503:physiopathology* / Q000517:prevention & control; D006706:Homeostasis; D006801:Humans; D007501:Iron / Q000378:metabolism*; D007502:Iron Chelating Agents / Q000627:therapeutic use; D019190:Iron Overload / Q000503:physiopathology*; D007640:Keratoconus / Q000473:pathology; D008268:Macular Degeneration / Q000503:physiopathology; D009901:Optic Nerve Diseases / Q000503:physiopathology; D020221:Optic Nerve Injuries / Q000503:physiopathology; D011625:Pterygium / Q000473:pathology; D017382:Reactive Oxygen Species
D000975:Antioxidants; D007502:Iron Chelating Agents; D017382:Reactive Oxygen Species; D007501:Iron