title: Sugary drinks in the pathogenesis of obesity and cardiovascular diseases.
abstract: Soft drink overconsumption is now considered to be a major public health concern with implications for cardiovascular diseases. This follows a number of studies performed in animals suggesting that chronic consumption of refined sugars can contribute to metabolic and cardiovascular dysregulation. In particular, the monosaccharide fructose has been attracting increasing attention as the more harmful sugar component in terms of weight gain and metabolic disturbances. High-fructose corn syrup is gradually replacing sucrose as the main sweetener in soft drinks and has been blamed as a potential contributor to the current high prevalence of obesity. There is also considerable evidence that fructose, rather than glucose, is the more damaging sugar component in terms of cardiovascular risk. This review focuses on the potential role of sugar drinks, particularly the fructose component, in the pathogenesis of obesity and cardiovascular diseases.
authors.affiliation: Division of Physiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland. clivemartin.brown@unifr.ch
authors.forename: C M
authors.initials: CM
authors.lastname: Brown
authors.forename: A G
authors.initials: AG
authors.lastname: Dulloo
authors.forename: J-P
authors.initials: JP
authors.lastname: Montani
mesh_terms: D050154:Adiposity; D000818:Animals; D001628:Beverages / Q000009:adverse effects*; D002110:Caffeine / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000209:etiology*; D019422:Dietary Sucrose / Q000009:adverse effects / Q000378:metabolism; D004285:Dogs; D005632:Fructose / Q000009:adverse effects* / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance; D009765:Obesity / Q000209:etiology*; D051381:Rats; D013549:Sweetening Agents / Q000009:adverse effects* / Q000378:metabolism; D014527:Uric Acid / Q000378:metabolism
chemical_list: D019422:Dietary Sucrose; D013549:Sweetening Agents; D014527:Uric Acid; D005632:Fructose; D002110:Caffeine