Efficacy of sodium hypochlorite and chlorhexidine against Enterococcus faecalis--a systematic review.
The efficacy of the sodium hypochlorite (NaOCl) and chlorhexidine (CHX) on Enterococcus faecalis was evaluated by systematic review and meta-analysis. The search strategies included search in electronic biomedical journal databases (MEDLINE, EMBASE, CENTRAL) and handsearching records, using different matches of keywords for NaOCl, CHX and Enterococcus faecalis. From 41 in vivo studies, 5 studies met the inclusion criteria. In a sample containing 159 teeth, E. faecalis was detected initially in 16 (10%) teeth by polymerase chain reaction (PCR) and 42 (26.4%) teeth by microbial culture techniques. After root canal disinfection, this species was observed in 11 (6.9%) teeth by PCR and 12 (7.5%) teeth by culture. Risk differences of included studies were combined as generic inverse variance data type (Review Manager Version 5.0 _ Cochrane Collaboration, http://www.cc-ims.net, accessed 15 May 2008), taking into account the separate tracking of positive and negative cultures/PCR. The level of statistical significance was set at p<0.05. In conclusion, NaOCl or CHX showed low ability to eliminate E. faecalis when evaluated by either PCR or culture techniques.
Estrela
Carlos
C
Federal University of Goiás, Goiânia, GO, Brazil. estrela3@terra.com.br
Silva
Julio Almeida
JA
de Alencar
Ana Helena Gonçalves
AH
Leles
Claudio Rodrigues
CR
Decurcio
Daniel Almeida
DA
D001431:Bacteriological Techniques; D002710:Chlorhexidine / Q000627:therapeutic use*; D019551:Dental Disinfectants / Q000627:therapeutic use; D003786:Dental Pulp Cavity / Q000382:microbiology; D013293:Enterococcus faecalis / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D016133:Polymerase Chain Reaction; D012388:Root Canal Irrigants / Q000627:therapeutic use*; D012973:Sodium Hypochlorite / Q000627:therapeutic use*; D016896:Treatment Outcome
D019551:Dental Disinfectants; D012388:Root Canal Irrigants; D012973:Sodium Hypochlorite; D002710:Chlorhexidine