title: Enantioselective separation of chiral vicinal diols in capillary electrophoresis using a mono-6(A)-aminoethylamino-beta-cyclodextrin as a chiral selector.
abstract: This paper describes an improved access to mono-6(A)-aminoethylamino-beta-CD (beta-CDen), a very efficient cationic chiral selector for CZE in the separation of eight chiral aromatic vicinal diols. The beta-CDen concentration has a strong influence on the efficiency of enantioseparation. The effects of the pH and concentration of the BGE, the capillary temperature, and the applied voltage on the resolution and separation selectivity have been studied. Excellent chiral resolution was achieved under the optimal conditions of beta-CDen 10 mM, pH 10, 200 mM borate buffer at 15 kV and 20 degrees C within 20 min. Moreover, the developed method was successfully applied to the determination of the enantiomeric purity of the catalytic asymmetric dihydroxylation (AD) reaction products.
authors.affiliation: Research Center for Chirotechnology, Fourth Military Medical University, Xi'an, Shaanxi, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Sun
authors.forename: Wei
authors.initials: W
authors.lastname: He
authors.forename: Ru
authors.initials: R
authors.lastname: Jiang
authors.forename: Pingan
authors.initials: P
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
authors.forename: Shengyong
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000438:Alcohols / Q000302:isolation & purification*; D001881:Borates / Q000737:chemistry; D004563:Electrochemistry; D019075:Electrophoresis, Capillary / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D015203:Reproducibility of Results; D013237:Stereoisomerism; D013696:Temperature; D047392:beta-Cyclodextrins / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000438:Alcohols; D001881:Borates; D047392:beta-Cyclodextrins