[Effects of bisoprolol on serum interleukin-6 and tumor necrosis factor-alpha level in patients with congestive heart failure].
OBJECTIVE
To investigate the levels of the serum interleukin-6(IL-6)and tumor necrosis factor-alpha (TNF-alpha) in patients with congestive heart failure (CHF) and to evaluate the beneficial effects of beta-blockers on the above variables.


METHODS
Studied 110 patients with CHF randomly treated with routine drugs (ACE Inhibitors, diuretics and vasodilator drugs, n=55) or additional beta-blocker bisoprolol (n=55). The levels of serum IL-6 and TNF-alpha in above patients with CHF at the different period of the course and in 50healthy humans were determined by radioimmunoassay. Simultaneously, the left ventricular ejective fraction (LVEF) of above patients were measured by nuclide ventricular imagery.


RESULTS
Compared with control group, the levels of serum IL-6 and TNF-alpha in patients with CHF were significantly increased during the course. There was a significantly negative correlation between IL-6, TNF-alpha and LVEF at 12 weeks after the treatment, and there were significant differences of serum IL-6 and TNF-alpha level among NYHA II, III and IV in CHF patients. The level of serum IL-6 and TNF-alpha were decreased more significantly in the bisoprolol group than in the routine group (P<0.05 ) .


CONCLUSIONS
Serum IL-6 and TNF-alpha level might play an important role in pathogenesis of CHF. Beta-blockers had suppress neurohumoral over activation in patients with CHF.
Tang
Fa-Kuan
FK
The Cardiovascular Department of the 2 Affiliated Hospital of Chinese PLA General Hospital, Beijing 100091, China.
Hua
Ning
N
Lu
Hong
H
Xiao
Jun
J
Tang
Xue-Zheng
XZ
Qi
Zhi
Z
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017298:Bisoprolol / Q000627:therapeutic use*; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha
D000319:Adrenergic beta-Antagonists; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D017298:Bisoprolol