Malaria pulls a FASt one.
Cure of rodent malaria with the biocide triclosan highlighted the enzyme FabI as an antimalarial drug target. In this issue of Cell Host & Microbe, Yu et al. (2008) show that FabI is not the principle target of triclosan yet plays an important role specifically in malaria liver stage development.
Spalding
Maroya D
MD
Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Prigge
Sean T
ST
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D064429:Fatty Acid Synthases / Q000037:antagonists & inhibitors*; D010963:Plasmodium falciparum / Q000187:drug effects*; D014260:Triclosan / Q000494:pharmacology*
D000962:Antimalarials; D014260:Triclosan; D064429:Fatty Acid Synthases