A note on the parameterization of Purcell's G x E model for ordinal and binary data.
Following the publication of Purcell's approach to the modeling of gene by environment interaction in 2002, the interest in G x E modeling in twin and family data increased dramatically. The analytic techniques described by Purcell were designed for use with continuous data. Here we explore the re-parameterization of these models for use with ordinal and binary outcome data. Analysis of binary and ordinal data within the context of a liability threshold model traditionally requires constraining the total variance to unity to ensure identification. Here, we demonstrate an alternative approach for use with ordinal data, in which the values of the first two thresholds are fixed, thus allowing the total variance to change as function of the moderator. We also demonstrate that when using binary data, constraining the total variance to unity for a given value of the moderator is sufficient to ensure identification. Simulation results indicate that analyses of ordinal and binary data can recover both the raw and standardized patterns of results. However, the scale of the results is dependent on the specification of (threshold or variance) constraints rather than the underlying distribution of liability. Example Mx scripts are provided.
Medland
Sarah E
SE
Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Queensland, Australia. sarahMe@qimr.edu.au
Neale
Michael C
MC
Eaves
Lindon J
LJ
Neale
Benjamin M
BM
D000465:Algorithms; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D004777:Environment; D005824:Genetics, Behavioral; D006801:Humans; D008957:Models, Genetic; D015233:Models, Statistical; D011381:Programming Languages; D012984:Software; D014427:Twins / Q000235:genetics*