title: Eccrine porocarcinoma.
abstract: Eccrine porocarcinoma (EPC) is a rare cutaneous neoplasm that grows slowly over a long period of time but often experiences an accelerated growth phase. This malignant tumor may arise denovo or evolve from a pre-existing benign eccrine poroma. Histologic evaluation demonstrates anaplastic cells involving the epidermis and infiltrating the dermis. Metastasis to regional lymph nodes distally occurs in a significant number of cases. Treatment modalities have included standard excision, Mohs micrographic surgery (MMS), chemotherapy, and radiation therapy. Recently sentinel lymph node biopsy has begun to be investigated as a staging tool. The literature on EPC is reviewed with attention paid to which of the various therapeutic options offers a clear advantage over the others. MMS affords the greatest likelihood of clear margins and cure in absence of regional and distant metastases.
authors.affiliation: Department of Dermatology, Rush University Medical Center, Chicago, Illinois 60612, USA. Clarence_W_Brown@rush.edu
authors.forename: Clarence William
authors.initials: CW
authors.lastname: Brown
authors.forename: Lady Christine
authors.initials: LC
authors.lastname: Dy
mesh_terms: D018250:Acrospiroma / Q000473:pathology / Q000628:therapy*; D000970:Antineoplastic Agents / Q000627:therapeutic use; D006801:Humans; D008207:Lymphatic Metastasis; D015580:Mohs Surgery; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D021701:Sentinel Lymph Node Biopsy; D013544:Sweat Gland Neoplasms / Q000473:pathology / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents