title: Fatty acid composition of the postmortem prefrontal cortex of adolescent male and female suicide victims.
abstract: Prior epidemiological, prospective intervention, and peripheral and central fatty acid composition studies suggest that omega-3 fatty acid deficiency may be associated with the pathoaetiology of depression and suicide. In the present study, we determined the fatty acid composition of the postmortem prefrontal cortex (PFC) of adolescent male and female suicide victims and age-matched controls. Fatty acid composition (wt% total fatty acids) and concentrations (micromol/g) were determined in the postmortem PFC (Brodmann area 10) of male and female adolescent (aged 13-20 years) suicide victims (n=20) and age-matched controls (n=20) by gas chromatography. None of the major polyunsaturated fatty acids including the principle brain omega-3 fatty acid, docosahexaenoic acid (DHA), monounsaturated fatty acids, or saturated fatty acids differed significantly between adolescent suicide victims and controls before or after segregation by gender. The arachidonic acid (AA, 20:4n-6): DHA ratio and adrenic acid (22:4n-6) composition were negatively correlated with age at death in controls but not in suicides, and males exhibited a greater AA:DHA ratio irrespective of cause-of-death. These results demonstrate that adolescent male and female suicide victims do not exhibit DHA deficits in the postmortem PFC relative to age-matched controls, and suggest that suicide victims do not exhibit the normal age-related decrease in adrenic acid composition and the AA:DHA ratio.
authors.affiliation: Department of Psychiatry, University of Cincinnati College of Medicine, Medical Science Building, 231 Albert Sabin Way, Cincinnati, OH 45267-0559, USA.
authors.forename: Robert K
authors.initials: RK
authors.lastname: McNamara
authors.forename: Ronald
authors.initials: R
authors.lastname: Jandacek
authors.forename: Therese
authors.initials: T
authors.lastname: Rider
authors.forename: Patrick
authors.initials: P
authors.lastname: Tso
authors.forename: Yogesh
authors.initials: Y
authors.lastname: Dwivedi
authors.forename: Rosalinda C
authors.initials: RC
authors.lastname: Roberts
authors.forename: Robert R
authors.initials: RR
authors.lastname: Conley
authors.forename: Ghanshyam N
authors.initials: GN
authors.lastname: Pandey
mesh_terms: D000293:Adolescent; D001344:Autopsy; D002648:Child; D003863:Depression / Q000503:physiopathology; D004032:Diet; D005227:Fatty Acids / Q000032:analysis*; D015525:Fatty Acids, Omega-3 / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D017397:Prefrontal Cortex / Q000737:chemistry*; D012044:Regression Analysis; D013405:Suicide; D055815:Young Adult
chemical_list: D005227:Fatty Acids; D015525:Fatty Acids, Omega-3