title: Inhibition of carrageenan-induced edema by tripleurospermum disciforme extract in rats.
abstract: In this research anti-inflammatory effect of Tripleurospermum disciforme extract was studied in rats. The effect of the extract against acute inflammation was studied by hind paw edema test. Intraperitoneal injection of different doses (15, 30, 45, 60, 90 and 120 mg kg(-1)) of Tripleurospermum disciforme which was followed by hind paw carageenan injection 1 h later were investigated. The resultant edema was quantified by measuring changes of diameter of hind foot. After 2, 3, 4 and 6 h we measured the anti-inflammatory effect of Tripleurospermum disciforme extract. Tripleurospermum disciforme extract with doses of 45, 60, 90 and 120 mg kg(-1) and indomethacin 5 mg kg(-1) showed significant effect. It is concluded that Tripleurospermum disciforme extract has anti-inflammatory effect against acute inflammation.
authors.affiliation: Department of Pharmacology, Medical Sciences, University of Tehran, Tehran, Iran.
authors.forename: Azam
authors.initials: A
authors.lastname: Bakhtiarian
authors.forename: Shahram
authors.initials: S
authors.lastname: Ejtemaimehr
authors.forename: Sylvia
authors.initials: S
authors.lastname: Strobl
authors.forename: Said
authors.initials: S
authors.lastname: Pournaghash-Tehrani
authors.forename: Alireza
authors.initials: A
authors.lastname: Partoazar
authors.forename: Guiti
authors.initials: G
authors.lastname: Ghamami
authors.forename: Narges
authors.initials: N
authors.lastname: Yasa
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D002351:Carrageenan / Q000037:antagonists & inhibitors* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D007213:Indomethacin / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D031169:Tripleurospermum / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D002351:Carrageenan; D007213:Indomethacin