Acute dilated cardiomyopathy in a patient with deficiency of long-chain 3-hydroxyacyl-CoA dehydrogenase.
Deficiency of long-chain 3-hydroxyacyl-coenzyme A (CoA) dehydrogenase (LCHADD) is a rare inborn error of metabolism. It is associated with hypertrophic cardiomyopathy and less frequently with dilated cardiomyopathy. The incidence and pathophysiology of cardiac involvement in LCHADD is poorly understood. This report describes the acute decompensation of a 3-year-old girl who had LCHADD with rapidly developing dilated cardiomyopathy. A review of the literature and possible causes of cardiomyopathy in LCHADD are explored.
Dyke
Peter C
PC
Department of Pediatrics, Nationwide Children's Hospital Heart Center, Columbus, OH 43205-2696, USA.
Konczal
Laura
L
Bartholomew
Dennis
D
McBride
Kim L
KL
Hoffman
Timothy M
TM
D000208:Acute Disease; D044942:Acyl-CoA Dehydrogenase, Long-Chain / Q000172:deficiency*; D002311:Cardiomyopathy, Dilated / Q000201:enzymology* / Q000235:genetics*; D002675:Child, Preschool; D005260:Female; D006801:Humans
D044942:Acyl-CoA Dehydrogenase, Long-Chain