title: Cell sex: a new look at cell fate studies.
abstract: Cell death processes have been widely investigated in recent years in order to elucidate the different pathways involved in the complex machinery implicated in determining cell fate. Different forms of cell death have been described: Apart from the classical form of death known as necrosis, a well-characterized traumatic injury of the cell, several additional forms of cell death have been identified. Of these, apoptosis has been characterized in the greatest detail. Defects in the mechanisms of cell demise (that is, an excess of or decrease in apoptosis) have been associated with the pathogenesis of a number of human diseases. Here we review some new aspects derived from recent insights into this field, particularly the hypothesis that cells of males and females could display several different features, including those determining their fate.
authors.affiliation: Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Maselli
authors.forename: Paola
authors.initials: P
authors.lastname: Matarrese
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Straface
authors.forename: Silvia
authors.initials: S
authors.lastname: Canu
authors.forename: Flavia
authors.initials: F
authors.lastname: Franconi
authors.forename: Walter
authors.initials: W
authors.lastname: Malorni
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D016923:Cell Death / Q000502:physiology; D002460:Cell Line; D045744:Cell Line, Tumor; D002477:Cells / Q000187:drug effects* / Q000473:pathology; D005260:Female; D005854:Germ Cells; D042341:Gonadal Hormones / Q000494:pharmacology* / Q000502:physiology; D006801:Humans; D008297:Male; D008954:Models, Biological; D009336:Necrosis; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism; D012737:Sex Factors
chemical_list: D042341:Gonadal Hormones; D017382:Reactive Oxygen Species