title: Intracranial hemorrhage in childhood immune thrombocytopenic purpura.
abstract: We retrospectively analyzed 750 patients with ITP for development of intracranial hemorrhage (ICH). Seventeen cases with age range of 10 months to 18 years were studied. Ten patients were of acute ITP and seven had chronic ITP. Nine patients developed ICH one month after the onset of ITP and five patients had ICH on presentation. ICH was precipitated by trauma in four patients and possibly the use of NSAIDs in one patient. Median platelets counts at the time of ICH were 12 x 10(9)/L (range 2-50 x 10(9)/L). Most patients were treated with corticosteroids. Four patients (24%) died due to ICH.
authors.affiliation: Department of Hematology, All India Institute of Medical Science, New Delhi, India. dr_drchoudhary@yahoo.com
authors.forename: Dharma R
authors.initials: DR
authors.lastname: Choudhary
authors.forename: Rahul
authors.initials: R
authors.lastname: Naithani
authors.forename: M
authors.initials: M
authors.lastname: Mahapatra
authors.forename: Rajat
authors.initials: R
authors.lastname: Kumar
authors.forename: Pravas
authors.initials: P
authors.lastname: Mishra
authors.forename: Renu
authors.initials: R
authors.lastname: Saxena
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D006259:Craniocerebral Trauma / Q000150:complications; D005260:Female; D006801:Humans; D007223:Infant; D020300:Intracranial Hemorrhages / Q000150:complications*; D008297:Male; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications* / Q000188:drug therapy; D012189:Retrospective Studies
chemical_list: D000305:Adrenal Cortex Hormones; D000894:Anti-Inflammatory Agents, Non-Steroidal