[Trospium chloride in combined treatment of females with genital prolapse and overactive urinary bladder].
The trial of efficacy of trospium chloride (TC) in a dose of 45 mg/day in females with overactive bladder (OAB) symptoms preserved after genital prolapse (GP) surgical correction included 28 females (age 55-82, mean age 68.07 +/- 12 years). GP was corrected by means of vaginal hysterectomy and anterior colporraphy. Treatment results were assessed 3 months after surgery basing on urine diary. Overall TC efficacy reached 82%. Symptoms attenuated in patients with and without detrusor overactivity: voiding frequency reduced by 31 and 24%, imperative voidings reduced by 26 and 8%, mean urine volume rose by 28 and 19%, respectively. Side effects were mild. TC demonstrated good efficacy in OAB patients, it noticeably improved quality of life.
Shkol'nikov
M e
Me
Mazo
E B
EB
Krivoborodov
G G
GG
Dobrokhotova
Iu E
IuE
Kaĭfadzhan
M M
MM
Fandeeva
L V
LV
Nurullin
R F
RF
Zhdanova
M S
MS
D000368:Aged; D000369:Aged, 80 and over; D001561:Benzilates; D005260:Female; D006801:Humans; D007045:Hysterectomy, Vaginal / Q000379:methods; D008875:Middle Aged; D009662:Nortropanes / Q000008:administration & dosage*; D010276:Parasympatholytics / Q000008:administration & dosage*; D011788:Quality of Life; D053201:Urinary Bladder, Overactive / Q000628:therapy*; D014596:Uterine Prolapse / Q000628:therapy*
D001561:Benzilates; D009662:Nortropanes; D010276:Parasympatholytics; C003330:trospium chloride