Antimicrobial activities of jadomycin B and structurally related analogues.
Natural products are leads for new antibiotics as a result of their structural complexity and diversity. We have isolated a series of structurally related polyketide-derived natural products from Streptomyces venezuelae ISP5230. The most active of these jadomycin analogues showed good activity against a variety of staphylococci, including methicillin-resistant Staphylococcus aureus.
Jakeman
David L
DL
College of Pharmacy, Dalhousie University, Halifax, Nova Scotia, Canada. david.jakeman@dal.ca
Bandi
Srinivasulu
S
Graham
Cathy L
CL
Reid
Taryn R
TR
Wentzell
Jason R
JR
Douglas
Susan E
SE
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D007546:Isoquinolines / Q000737:chemistry / Q000494:pharmacology; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013212:Staphylococcus epidermidis / Q000187:drug effects; D013302:Streptomyces / Q000187:drug effects* / Q000235:genetics
D000900:Anti-Bacterial Agents; D007546:Isoquinolines; C081750:jadomycin B