title: Micronucleus analysis in patients with colorectal adenocarcinoma and colorectal polyps.
abstract: OBJECTIVE
  To determine, by counting micronucleus (MN) frequencies, whether chromosomal or DNA damage have an effect on the pathogenesis of early colorectal adenocarcinoma (CRC).
  
  
  METHODS
  We analyzed MN frequencies in 21 patients with CRC, 24 patients with colon polyps [10 neoplastic polyps (NP) and 14 non-neoplastic polyps (NNP)] and 20 normal controls.
  
  
  RESULTS
  MN frequency was significantly increased in CRC patients and in NP patients compared with controls (3.72 +/- 1.34, 3.58 +/- 1.21 vs 1.97 +/- 0.81, P < 0.001). However, there was no difference in the MN frequency between CRC patients and NP patients (P > 0.05). Similarly, there was no difference in the MN frequency between NNP patients (2.06 +/- 0.85) and controls (P > 0.05).
  
  
  CONCLUSIONS
  Our results suggest increased chromosome/DNA instabilities may be associated with the pathogenesis of early CRC.
authors.affiliation: Erzurum Training and Research Hospital, Department of Medical Genetics, Erzurum 25240, Turkey. alikaramandr@hotmail.com
authors.forename: Ali
authors.initials: A
authors.lastname: Karaman
authors.forename: Doğan Nasir
authors.initials: DN
authors.lastname: Binici
authors.forename: Mehmet Eşref
authors.initials: ME
authors.lastname: Kabalar
authors.forename: Züleyha
authors.initials: Z
authors.lastname: Calikuşu
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000368:Aged; D016022:Case-Control Studies; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002478:Cells, Cultured; D003111:Colonic Polyps / Q000235:genetics* / Q000473:pathology; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D042822:Genomic Instability; D006801:Humans; D008297:Male; D048629:Micronuclei, Chromosome-Defective; D015162:Micronucleus Tests; D008875:Middle Aged; D011230:Precancerous Conditions / Q000235:genetics* / Q000473:pathology