title: Use of imaging in restorative stroke trials.
abstract: Restorative therapies aim to improve behavioral outcome after stroke by promoting repair and restoration. Measures of CNS injury and function might be useful to evaluate such therapies in a clinical trial, for example, by optimizing patient selection or treatment dose. These issues are considered in this review, with specific examples provided.
authors.affiliation: University of California, Irvine Medical Center, 101 The City Drive South, Building 53 Room 203, Orange, CA 92868-4280, USA. scramer@uci.edu
authors.forename: Steven C
authors.initials: SC
authors.lastname: Cramer
mesh_terms: D002986:Clinical Trials as Topic; D003952:Diagnostic Imaging / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging; D018579:Patient Selection; D049268:Positron-Emission Tomography; D020521:Stroke / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy*; D014057:Tomography, X-Ray Computed; D050781:Transcranial Magnetic Stimulation; D016896:Treatment Outcome