Cucurbituril-based nanoparticles: a new efficient vehicle for targeted intracellular delivery of hydrophobic drugs.
Cucurbituril-based nanoparticles (CB[6]NPs) serve as new efficient vehicles for delivery of hydrophobic drugs, which have unique features including (1) a high drug loading capacity and efficiency, (2) noncovalently tunable surfaces, (3) efficient delivery of hydrophobic drugs into a cancer cell by receptor-mediated endocytosis, and (4) facile release of drugs into cytoplasm, which enhances the pharmaceutical effects of the drugs.
Park
Kyeng Min
KM
Department of Chemistry, Pohang University of Science and Technology, Pohang, 790-784, Korea.
Suh
Kyungwon
K
Jung
Hyuntae
H
Lee
Don-Wook
DW
Ahn
Youngjoo
Y
Kim
Jeeyeon
J
Baek
Kangkyun
K
Kim
Kimoon
K
D004396:Coloring Agents; D003593:Cytoplasm / Q000187:drug effects / Q000378:metabolism; D016503:Drug Delivery Systems; D006367:HeLa Cells; D006801:Humans; D047028:Macrocyclic Compounds / Q000737:chemistry; D018613:Microscopy, Confocal; D053758:Nanoparticles / Q000737:chemistry*; D010078:Oxazines; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D014677:Pharmaceutical Vehicles / Q000737:chemistry*; D010777:Photochemistry; D012995:Solubility; D014867:Water; D000099246:Cucurbit(n)urils
D004396:Coloring Agents; D047028:Macrocyclic Compounds; D010078:Oxazines; D004364:Pharmaceutical Preparations; D014677:Pharmaceutical Vehicles; D014867:Water; D000099246:Cucurbit(n)urils; C044808:nile red