title: [SPECT and FDG-PET in diagnostics of neurolues].
abstract: Syphilis is a recurrent treponematosis of acute and chronic evolution. In general it is either sexually or congenitally transmitted. Primary syphilis appears as a single and painless lesion. Secondary syphilis may manifest years later, the secondary bacteremic stage is accompanied by generalized mucocutaneous lesions. Tertiary disease can be disseminated to bones and virtually any organ, involving principally the ascending aorta and the central nervous system. Nuclear medicine provides diagnostic methods in case of skeletal manifestations by bone scan - identifying periostitis and osteomyelitis. Hepatic gummas can be imaged by 99m-Tc-colloid liver scintigraphy. In neurosyphilis brain perfusion SPECT enables imaging of cerebral involvement by small vessel endarteritis resulting from syphilitic vascular disease. 18-FDG PET is also useful to evaluate neurosyphilis, a reduction of brain glucose consumption is observed. The technique adequately enables imaging of therapeutic response and might be superior to morphologic imaging. We present our experiences with these nuclear medicine methods in patients with neurolues. The incidence of neurolues is estimated at 2 per 100.000 inhabitants worldwide, migration processes might bring a re-emergence of this disease to Austria and other developed countries of the EU. Scintigraphic methods should be kept in mind for diagnostic evaluation of neurosyphilis.
authors.affiliation: Institut für Nuklearmedizin, Wagner-Jauregg Krankenhaus, Linz, Osterreich. robert.pichler@gespag.at
authors.forename: Robert
authors.initials: R
authors.lastname: Pichler
authors.forename: Stefan
authors.initials: S
authors.lastname: Doppler
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Szalay
authors.forename: Christine
authors.initials: C
authors.lastname: Hertl
authors.forename: Ulrich
authors.initials: U
authors.lastname: Knell
authors.forename: Johanna
authors.initials: J
authors.lastname: Winkler
mesh_terms: D000328:Adult; D001479:Basal Ganglia / Q000000981:diagnostic imaging; D001786:Blood Glucose / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging*; D003545:Cysteine / Q000031:analogs & derivatives; D003704:Dementia / Q000000981:diagnostic imaging; D003937:Diagnosis, Differential; D004200:Diseases in Twins; D019788:Fluorodeoxyglucose F18; D005625:Frontal Lobe / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D009494:Neurosyphilis / Q000000981:diagnostic imaging*; D015609:Organotechnetium Compounds; D049268:Positron-Emission Tomography; D012680:Sensitivity and Specificity; D013589:Syphilis, Cardiovascular / Q000000981:diagnostic imaging; D013590:Syphilis, Congenital / Q000000981:diagnostic imaging; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D001786:Blood Glucose; D015609:Organotechnetium Compounds; D019788:Fluorodeoxyglucose F18; C059659:technetium Tc 99m bicisate; D003545:Cysteine