Two polymorphs of chlorpropamide: the delta-form and the high-temperature epsilon-form.
The epsilon-form of chlorpropamide [systematic name: 4-chloro-N-(propylaminocarbonyl)benzenesulfonamide], C(10)H(13)ClN(2)O(3)S, has been obtained as single crystals from solution (and not as a polycrystalline sample by heating the alpha-, gamma- or delta-forms). The results of anisotropic structure refinements for the epsilon- and delta-forms are reported. The density of the delta-polymorph is the highest, and that of the epsilon-polymorph the lowest, among the five known chlorpropamide polymorphs. The main intermolecular hydrogen-bonding pattern in polymorphs delta and epsilon is the same as in polymorphs alpha, beta and gamma, but the conformations differ. The densities of the polymorphs were found to depend on the molecular conformations.
Drebushchak
Tatiana N
TN
Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation. tanya@xray.nsu.ru
Chukanov
Nikita V
NV
Boldyreva
Elena V
EV
D016880:Anisotropy; D002747:Chlorpropamide / Q000737:chemistry*; D003461:Crystallography; D015394:Molecular Structure; D013696:Temperature
D002747:Chlorpropamide