Adverse effects of propranolol on reproductive function in adult male mice.
Ingestion of propranolol at 10 and 15 mg kg(-1) body weight for 35 days by adult male mice was investigated for its effects on fertility. Body weight and absolute and relative testes weights were reduced and the average weights of epididymis, ventral prostate and seminal vesicle decreased significantly. A significant decline of spermatogenesis in testes due to a decrease in the number of primary, secondary spermatocytes and spermatids in the treatment group 2 (15 mg kg(-1)) is attributed to a significant decrease in testosterone, LH and FSH. Sperm motility and density were also significantly decreased in the cauda epididymis and in the testes of group 2 treated male mice. In addition, the treatment markedly increased the number of fetal resorptions in female mice impregnated by the group 2 males, thereby reducing their fertility.
Nusier
Mohamad K
MK
Department of Biochemistry and Molecular Biology, Jordan University of Science and Technology, School of Medicine, Irbid 22110, Jordan.
Bataineh
Hameed N
HN
Daradka
Haytham M
HM
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004822:Epididymis / Q000033:anatomy & histology / Q000187:drug effects; D004958:Estradiol / Q000031:analogs & derivatives / Q000494:pharmacology; D005260:Female; D005298:Fertility / Q000187:drug effects*; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D011433:Propranolol / Q000494:pharmacology*; D011467:Prostate / Q000033:anatomy & histology / Q000187:drug effects; D012098:Reproduction / Q000187:drug effects / Q000502:physiology*; D012669:Seminal Vesicles / Q000033:anatomy & histology / Q000187:drug effects
C074283:estradiol 3-benzoate; D004958:Estradiol; D011433:Propranolol