Copper-free 'click': 1,3-dipolar cycloaddition of azides and arynes.
Arynes formed through fluoride-promoted ortho-elimination of o-(trimethylsilyl)aryl triflates can undergo [3 + 2] cycloaddition with various azides to form substituted benzotriazoles. The rapid reaction times and mild conditions make this an attractive variation of the classical 'click' reaction of azides and alkynes.
Campbell-Verduyn
Lachlan
L
Stratingh Institute for Chemistry, University of Groningen, Groningen, The Netherlands.
Elsinga
Philip H
PH
Mirfeizi
Leila
L
Dierckx
Rudi A
RA
Feringa
Ben L
BL