Antimicrobial and cytotoxic activity of Marrubium alysson and Retama raetam grown in Tunisia.
Antibacterial and antifungal activities of extracts obtained from M. alysson, R. raetam were tested using a solid medium technique. We showed that the petroleum ether extract of M. alysson had a Minimum Inhibitory Concentration (MIC) varied from 128 to 2000 microg mL(-1) against different Enterobacteriaceae and antifungal activity against Candida glabrata, Candida albicans, Candida parapsilosis and Candida kreusei with a MIC of 256 microg mL(-1). The ethyl acetate extract of R. raetam showed the best activity against Gram positive organisms with MICs of 128 to 256 microg mL(-1) against methicillin resistant Staphylococcus aureus but low activity against the different Candida species.
Hayet
Edziri
E
Laboratoire Des Maladies Transmissibles et Des Substances Biologiquement Actives-Faculté de Pharmacie-5000-Monastir, Tunisie.
Samia
Ammar
A
Patrick
Groh
G
Ali
Mahjoub Mohamed
MM
Maha
Mastouri
M
Laurent
Gutmann
G
Mighri
Zine
Z
Mahjoub
Laouni
L
D000818:Animals; D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects*; D002522:Chlorocebus aethiops; D039761:Genista / Q000737:chemistry*; D027522:Marrubium / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D014416:Tunisia; D014709:Vero Cells
D000890:Anti-Infective Agents; D010936:Plant Extracts