title: The polycystic ovary syndrome does not predict further miscarriage in Japanese couples experiencing recurrent miscarriages.
abstract: OBJECTIVE
  It has been a matter of controversy whether the polycystic ovary syndrome (PCOS) is actually a causal factor of miscarriages because of the absence of internationally established criteria. We, therefore, in this study investigated whether PCOS and a polycystic ovary (PCO) morphology have predictive value for subsequent miscarriages using new International and Japanese criteria.
  
  
  METHODS
  A total of 195 patients with a history of two consecutive first trimester miscarriages and without abnormal chromosomes in either partner, antiphospholipid antibodies or uterine anomalies, were examined. The prospective pregnancy outcome was compared between patients with and without PCOS, PCO morphology, elevated luteinizing hormone (LH), hyperandrogenism and obesity.
  
  
  RESULTS
  Of a total of 195 patients, 56 (28.7%) miscarried subsequently. Three (1.5%) and 12 (6.2%) were diagnosed as suffering from PCOS by Japanese and International criteria respectively. There was no relation between a diagnosis of PCOS, PCO morphology, elevated LH, free testosterone or obesity and the subsequent miscarriage rate.
  
  
  CONCLUSIONS
  A routine test for diagnosis of PCOS is not necessary in patients experiencing recurrent miscarriages because none of the related parameters examined in this study predicted subsequent miscarriage.
authors.affiliation: Department of Obstetrics and Gynecology, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan. og.mym@med.nagoya-cu.ac.jp
authors.forename: Mayumi
authors.initials: M
authors.lastname: Sugiura-Ogasawara
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sato
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Suzumori
authors.forename: Tamao
authors.initials: T
authors.lastname: Kitaori
authors.forename: Kyoko
authors.initials: K
authors.lastname: Kumagai
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Ozaki
mesh_terms: D000026:Abortion, Habitual / Q000276:immunology; D000328:Adult; D005191:Family Characteristics; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D011085:Polycystic Ovary Syndrome / Q000276:immunology*; D011247:Pregnancy