title: Automatic segmentation and recognition of lungs and lesion from CT scans of thorax.
abstract: In this study, a fully automated texture-based segmentation and recognition system for lesion and lungs from CT of thorax is presented. For the segmentation part, we have extracted texture features by Gabor filtering the images, and, then combined these features to segment the target volume by using Fuzzy C Means (FCM) clustering. Since clustering is sensitive to initialization of cluster prototypes, optimal initialization of the cluster prototypes was done by using a Genetic Algorithm. For the recognition stage, we have used cortex like mechanism for extracting statistical features in addition to shape-based features. The segmented regions showed a high degree of imbalance between positive and negative samples, so we employed over and under sampling for balancing the data. Finally, the balanced and normalized data was subjected to Support Vector Machine (SimpleSVM) for training and testing. Results reveal an accuracy of delineation to be 94.06%, 94.32% and 89.04% for left lung, right lung and lesion, respectively. Average sensitivity of the SVM classifier was seen to be 89.48%.
authors.affiliation: Department of Radiation Biology, Institute for Cancer Research, Rikshospitalet-Radiumhospitalet Medical centre, Oslo, Norway. Manish.Kakar@rr-research.no
authors.forename: Manish
authors.initials: M
authors.lastname: Kakar
authors.forename: Dag Rune
authors.initials: DR
authors.lastname: Olsen
mesh_terms: D019412:Anatomy, Cross-Sectional / Q000379:methods; D016000:Cluster Analysis; D017143:Fuzzy Logic; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods; D008168:Lung / Q000000981:diagnostic imaging* / Q000473:pathology; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D015233:Models, Statistical; D016571:Neural Networks, Computer; D009664:Norway; D010363:Pattern Recognition, Automated / Q000379:methods*; D013902:Radiography, Thoracic / Q000379:methods; D012680:Sensitivity and Specificity; D013909:Thorax / Q000473:pathology; D014057:Tomography, X-Ray Computed / Q000379:methods*