title: Dcp1a phosphorylation along neuronal development and stress.
abstract: Decapping protein 1a (Dcp1a) is found in P-bodies and functions in mRNA cap removal prior to its degradation. The function and binding partners of Dcp1a have been thoroughly studied, however its expression pattern is still unclear. In this study we have monitored Dcp1a expression along brain development, neuronal differentiation and during cellular stress. We found that Dcp1a is hyperphosphorylated under these physiological conditions. We followed our observations and identified the specific amino acid residues that are phosphorylated. These findings suggest a novel post-translational modification that may influence the function of Dcp1a in response to various physiological cues.
authors.affiliation: Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel. Jacob.Blumenthal@weizmann.ac.il
authors.forename: Jacob
authors.initials: J
authors.lastname: Blumenthal
authors.forename: Leah
authors.initials: L
authors.lastname: Behar
authors.forename: Evan
authors.initials: E
authors.lastname: Elliott
authors.forename: Irith
authors.initials: I
authors.lastname: Ginzburg
mesh_terms: D000596:Amino Acids / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001149:Arsenates / Q000494:pharmacology; D002460:Cell Line; D004722:Endoribonucleases / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D009154:Mutation; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D010766:Phosphorylation; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism*
chemical_list: D000596:Amino Acids; D001149:Arsenates; D015534:Trans-Activators; C030052:mRNA decapping enzymes; D004722:Endoribonucleases; C466280:smad4-interacting protein SMIF, mouse; C025657:arsenic acid