title: [Comparison of TD-fentanyl with sustained-release morphine in the pain treatment of patients with lung cancer].
abstract: Comparison of TD-fentanyl with sustained-release morphine in the pain treatment of patients with lung cancer
  
  
  OBJECTIVE
  The aim of this randomized and controlled trial was to evaluate the analgesic efficacy of trans-dermal fentanyl (TDF) and sustained-release oral morphine (SRM) primarily and their side effects secondarily, in patients with chronic lung cancer-related pain.
  
  
  METHODS
  According to three step analgesic guidelines recommended by the World Health Organization, 50 chronic lung cancer patients requiring third line therapy were enrolled and received either TDF patch (Grup F, n=25) or SRM per orally (Grup M, n=25) for 15 days. Patients were assessed in view to numeric rating scale of their pain, as well as the drugs' side effects like constipation, nausea-vomiting, urinary retention and urticaria, hypoventilation.
  
  
  RESULTS
  Pain scores were similar for both groups at the beginning (p>0.05). While significantly lower pain scores were achieved on the 7th and 15th days compared to those of initial values in Group F and Group M patients (p<0.001); these decreases did not reach statistical significance between the groups (p>0.05). Compared to Group M, constipation was significantly lower in Group F (14 patients and 64% vs. 6 patients and 27%, respectively) (p=0.03). However, the frequencies of nausea-vomiting, urinary retention and urticaria were different between the groups (p>0.5). None of the patients developed hypoventilation.
  
  
  CONCLUSIONS
  Both TDF and SRM are safe and effective analgesics for the management of chronic cancer pain. However, TDF is associated with significantly less constipation rate than that of with SRM.
authors.affiliation: Department of Anaesthesiology, Dr. Suat Seren Teaching and Research Hospital, Izmir, Turkey. ozturktulun@yahoo.com
authors.forename: Tülün
authors.initials: T
authors.lastname: Oztürk
authors.forename: Kaan
authors.initials: K
authors.lastname: Karadibak
authors.forename: Deniz
authors.initials: D
authors.lastname: Catal
authors.forename: Aydan
authors.initials: A
authors.lastname: Cakan
authors.forename: Fevziye
authors.initials: F
authors.lastname: Tugsavul
authors.forename: Kadri
authors.initials: K
authors.lastname: Cirak
mesh_terms: D000279:Administration, Cutaneous; D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000009:adverse effects; D002908:Chronic Disease; D003692:Delayed-Action Preparations; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage* / Q000009:adverse effects; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D000701:Analgesics, Opioid; D003692:Delayed-Action Preparations; D009020:Morphine; D005283:Fentanyl