title: Sickle cell crisis leading to extensive necrosis in a low-grade glioma and masquerading high-grade lesion.
abstract: A 9-year-old female child presented with rapid neurological deterioration. Clinical features and imaging findings were suggestive of high-grade malignancy, and hematological investigations were suggestive of sickle cell trait. Histopathology showed features of low-grade malignancy and extensive intratumoral sickling. We hypothesize that the vicious cycle of hypoxia, sickling, thrombosis, ischemia and infarction resulted in the extensive tumor necrosis in the present case causing the initial symptoms and rapid deterioration in the condition of the patient.
authors.affiliation: Division of Neurosurgery, Department of Surgery, Datta Meghe Institute of Medical Sciences, Sawangi (Meghe), Wardha, India. dramit_in@yahoo.com
authors.forename: Amit
authors.initials: A
authors.lastname: Agrawal
authors.forename: D N
authors.initials: DN
authors.lastname: Balpande
authors.forename: A
authors.initials: A
authors.lastname: Khan
authors.forename: S J
authors.initials: SJ
authors.lastname: Vagh
authors.forename: Samarth
authors.initials: S
authors.lastname: Shukla
authors.forename: Sumit
authors.initials: S
authors.lastname: Chopra
mesh_terms: D000755:Anemia, Sickle Cell / Q000150:complications / Q000175:diagnosis* / Q000473:pathology*; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology*; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D005910:Glioma / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology*; D006801:Humans; D009336:Necrosis