title: Syntheses and evaluation of glucosyl aryl thiosemicarbazide and glucosyl thiosemicarbazone derivatives as antioxidant and anti-dyslipidemic agents.
abstract: A series of N-per-O-acetyl-glucosyl arylthiosemicarbazide and thiosemicarbazone derivatives have been synthesized and evaluated for their in vivo anti-dyslipidemic and in vitro antioxidant activities. Among 16 compounds tested, 3 compounds showed potent anti-dyslipidemic activity and 6 compounds showed potent antioxidant and scavenger of oxygen free radicals activity.
authors.affiliation: Division of Molecular Medicine, Bose Institute, P-1/12, C.I.T. Scheme VII-M, Kolkata 700054, India; Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, India.
authors.forename: Samir
authors.initials: S
authors.lastname: Ghosh
authors.forename: Anup Kumar
authors.initials: AK
authors.lastname: Misra
authors.forename: Gitika
authors.initials: G
authors.lastname: Bhatia
authors.forename: M M
authors.initials: MM
authors.lastname: Khan
authors.forename: A K
authors.initials: AK
authors.lastname: Khanna
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D050171:Dyslipidemias / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D012663:Semicarbazides / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D000960:Hypolipidemic Agents; D012663:Semicarbazides; D013882:Thiosemicarbazones; C005151:thiosemicarbazide