title: Cytotoxic polyprenylated xanthones from the resin of Garcinia hanburyi.
abstract: Twelve new xanthones (1-12), a pair of new natural products (13 and 14), and 18 known related compounds were isolated from the resin of Garcinia hanburyi. The structures of 1-14 were elucidated by detailed spectroscopic analyses. A cytotoxic assay of the isolated compounds revealed that, with the exception of 2, these compounds were active against the HeLa tumor cell line.
authors.affiliation: Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Zhangjiang, Shanghai 201203, People's Republic of China.
authors.forename: Si-Jia
authors.initials: SJ
authors.lastname: Tao
authors.forename: Shu-Hong
authors.initials: SH
authors.lastname: Guan
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Lu
authors.forename: Guang-Tong
authors.initials: GT
authors.lastname: Chen
authors.forename: Na
authors.initials: N
authors.lastname: Sha
authors.forename: Qing-Xi
authors.initials: QX
authors.lastname: Yue
authors.forename: Xuan
authors.initials: X
authors.lastname: Liu
authors.forename: De-An
authors.initials: DA
authors.lastname: Guo
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002681:China; D004354:Drug Screening Assays, Antitumor; D029760:Garcinia / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D012116:Resins, Plant / Q000737:chemistry; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012116:Resins, Plant; D044004:Xanthones