Biological effects of a chayotte extract in Wistar rats with induced diabetes: a radiopharmaceutically analysis.
The present research evaluated the influence of a chayotte (Sechium edule) extract (macerated) on the bioavailability of 99TcO4Na as well as in the mass of the organs. In this study, in the biodistribution analysis, the 99mTcO4Na was administrated into female Wistar rats (diabetes and no diabetes induced) which had drunk or not the extract for 7 days. After 10 min, animals were sacrificed, the organs were isolated, the radioactivity determined in a well counter and the percentages of radioactivity per gram (%ATI/g) in the organs and mass of them (g) were calculated. The analysis of the results has indicated that in the diabetes group had been an increase in the uptake of 99mTcO4Na the in pancreas as well as in the diabetes groups treated with chayotte extract. The mass of the spleen, stomach, pancreas, heart and kidney has been altered due to the comparison of the groups. It is possible to suggest that some components of chayotte extracts present an oxidant power able to alter the biodistribution of 99mTcO4Na, as a tip, we speculate that the referred extract when metabolized in the liver may produce reactive metabolites with oxidant properties linked to the stress which is generated by diabetic status, this fact could justify by the increase of %ATI/g in the pancreas which probably may be due to the producing of AGEs in diabetes status as well as by the different molecular and cellular mechanisms related to the effects of the extract and diabetes would promote differences in the mass of the organs.
Diré
G F
GF
Universidade do Estado do Rio de Janeiro, Instituto de Biologia Roberto Alcantara Gomes, Departament de Biofísica, Av. 28 de setembro, 87, Rio de Janeiro, RJ 20551-030, Brazil.
Rodrigues
J S
JS
Oliveira
J C S
JC
Vasconcelos
S D D
SD
Siqueira
P R A
PR
Duarte
R M
RM
Almeida
M C L
MC
Fernandes
M L
ML
Bernardo-Filho
M
M
D000818:Animals; D019662:Cucurbitaceae / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000532:radiotherapy*; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D010936:Plant Extracts; D019275:Radiopharmaceuticals