title: An efficient one-pot procedure for asymmetric bifunctionalization of 5,15-disubstituted porphyrins: a simple preparation of meso acyl-, alkoxycarbonyl-, and carbamoyl-substituted meso-formylporphyrins.
abstract: An efficient one-pot procedure which converts 5,15-disubstituted porphyrins into their corresponding meso acyl-, alkoxycarbonyl-, and carbamoyl-substituted meso-formylporphyrins has been developed, where the procedure involves a sequential S(N)Ar reaction of porphyrins with PyMe(2)SiCH(2)Li, followed by acylation or related reactions and oxidation.
authors.affiliation: Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose, Tokyo 204-8588, Japan. takanami@my-pharm.ac.jp
authors.forename: Toshikatsu
authors.initials: T
authors.lastname: Takanami
authors.forename: Atsushi
authors.initials: A
authors.lastname: Wakita
authors.forename: Jun
authors.initials: J
authors.lastname: Matsumoto
authors.forename: Sadashige
authors.initials: S
authors.lastname: Sekine
authors.forename: Kohji
authors.initials: K
authors.lastname: Suda
mesh_terms: D000215:Acylation; D007202:Indicators and Reagents; D018020:Lithium Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D010084:Oxidation-Reduction; D011166:Porphyrins / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D007202:Indicators and Reagents; D018020:Lithium Compounds; D011166:Porphyrins