Olmesartan reduced microalbuminuria in Japanese subjects with type 2 diabetes.
We investigated the effect of olmesartan on early diabetic nephropathy in hypertensive patients with type 2 diabetes by its replacement of other angiotensin II type 1 receptor blockers (ARBs) by olmesartan. The urinary albumin/creatinine ratio significantly decreased. The present result suggests a possibility that olmesartan may have more effect on early nephropathy than other ARBs.
Ikeda
Hiroki
H
Center for Diabetes & Endocrinology, The Tazuke Kofukai Foundation Medical Research Institute Kitano Hospital, Osaka, Japan.
Hamamoto
Yoshiyuki
Y
Honjo
Sachiko
S
Nabe
Koichiro
K
Wada
Yoshiharu
Y
Koshiyama
Hiroyuki
H
D000368:Aged; D000419:Albuminuria; D047228:Angiotensin II Type 1 Receptor Blockers / Q000627:therapeutic use*; D044466:Asian People; D001562:Benzimidazoles / Q000627:therapeutic use; D001565:Benzoates / Q000627:therapeutic use; D001713:Biphenyl Compounds; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000188:drug therapy* / Q000652:urine; D003928:Diabetic Nephropathies / Q000517:prevention & control*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications*; D007093:Imidazoles / Q000627:therapeutic use*; D019808:Losartan / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D000077333:Telmisartan; D013777:Tetrazoles / Q000627:therapeutic use*; D014633:Valine / Q000031:analogs & derivatives / Q000627:therapeutic use; D000068756:Valsartan
D047228:Angiotensin II Type 1 Receptor Blockers; D001562:Benzimidazoles; D001565:Benzoates; D001713:Biphenyl Compounds; D007093:Imidazoles; D013777:Tetrazoles; D000068756:Valsartan; C437965:olmesartan; D014633:Valine; D019808:Losartan; C081643:candesartan; D000077333:Telmisartan