Progress in research on the anti-tumor effect of artesunate.
It has been found in recent years that Artesunate (Art), a water soluble derivative of arteannuin, mainly previously used for its anti-malarial activity, has some other effects, e.g. it could act as an anti-tumor agent by way of inducing cell apoptosis, antagonizing angiogenesis, reversing immunosuppression of tumor cells, etc. More and more attention is being paid to the anti-tumor effects of Art. Such progress is reviewed in this paper.
HE
Rong-rong
RR
Gulou Medical College of Integrative Chinese and Western Medicine, The No.1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing (210029), China.
ZHOU
Huai-jun
HJ
D000563:Amebicides / Q000494:pharmacology*; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D037621:Artemisinins / Q000494:pharmacology*; D000077332:Artesunate; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D007165:Immunosuppression Therapy; D007501:Iron / Q000494:pharmacology; D009389:Neovascularization, Pathologic / Q000188:drug therapy; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000563:Amebicides; D000962:Antimalarials; D000970:Antineoplastic Agents; D037621:Artemisinins; D005609:Free Radicals; D000077332:Artesunate; D007501:Iron