[Molecular biology and prostate cancer: evolution or revolution?].
The identification of fusion genes provides new insights into the initial mechanisms of molecular events implicated in the tumorigenesis of prostate cancer. The presence of TEMPRSS2-ETS fusion in up to half of all human prostate cancers makes it perhaps the most common genetic rearrangement in human epithelial tumors. Some data suggest that TMPRSS2-ERG fusion prostate cancers have a more aggressive phenotype which may affect cancer progression and outcome in localized tumors treated with prostatectomy. This discovery should pave the way towards future targeted therapies.
Molinié
Vincent
V
Service de pathologie, groupe hospitalier Paris-Saint-Joseph, 185, rue Raymond-Losserand, 75014 Paris, France. vmolinie@hpsj.fr
Beuzeboc
Philippe
P
Mahjoub
Wafa K
WK
D002453:Cell Cycle / Q000235:genetics; D002455:Cell Division / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics; D004231:Diuresis; D050939:Gene Fusion; D016259:Genes, myc; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008967:Molecular Biology / Q000379:methods*; D009857:Oncogenes; D011468:Prostatectomy / Q000379:methods; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D050783:Proto-Oncogene Proteins c-ets / Q000235:genetics; D013489:Suppression, Genetic
D004273:DNA, Neoplasm; D005819:Genetic Markers; D050783:Proto-Oncogene Proteins c-ets