The genetics of primary open-angle glaucoma: a review.
Glaucoma is the major cause of irreversible blindness worldwide. Primary open-angle glaucoma (POAG), as the most prevalent form of glaucoma, is a complex inherited disorder and affects more than 2 million individuals in the United States. It has become increasingly clear that a host of genetic as well as environmental factors are likely to contribute to the phenotype. A number of chromosomal and genetic associations have been reported for POAG. This review examines what is currently known about the underlying genetic structure, what remains to be learned, and how this may affect our medical management of this major blinding disease.
Allingham
R Rand
RR
Duke University Eye Center, Duke University, Durham, NC 27710, USA. allin002@mc.duke.edu
Liu
Yutao
Y
Rhee
Douglas J
DJ
D018797:Cell Cycle Proteins; D002874:Chromosome Mapping / Q000379:methods; D003598:Cytoskeletal Proteins / Q000235:genetics; D005136:Eye Proteins / Q000235:genetics*; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005902:Glaucoma, Open-Angle / Q000235:genetics*; D006023:Glycoproteins / Q000235:genetics; D006801:Humans; D026901:Membrane Transport Proteins; D009154:Mutation; D035582:Transcription Factor TFIIIA / Q000235:genetics; D000099179:Myocilin
D018797:Cell Cycle Proteins; D003598:Cytoskeletal Proteins; D005136:Eye Proteins; D006023:Glycoproteins; D026901:Membrane Transport Proteins; D035582:Transcription Factor TFIIIA; D000099179:Myocilin; C409460:OPTN protein, human; C502341:WDR36 protein, human