title: Germline polymorphism of cancer susceptibility genes in gynecologic cancer.
abstract: The multifactorial process of carcinogenesis involves mutations in oncogenes, or tumor suppressor genes, as well as the influence of environmental etiological factors. Common DNA polymorphisms in low penetrance genes have emerged as genetic factors that seem to modulate an individual's susceptibility to malignancy. Genetic studies, which lead to a true association, are expected to increase understanding of the pathogenesis of each malignancy and to be a powerful tool for prevention and prognosis in the future. Here, we review the findings of genetic association studies of gene polymorphisms in gynecologic cancer with special reference to glutathione-S-transferase, FAS/CD95 and p53 genes including our recent research results.
authors.affiliation: Cytopathology and Gynecology, Osaka Cancer Prevention and Detection Center, Osaka, Japan. mueda@gan-osaka.or.jp
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Ueda
authors.forename: Eisaku
authors.initials: E
authors.lastname: Toji
authors.forename: Osamu
authors.initials: O
authors.lastname: Nunobiki
authors.forename: Shinji
authors.initials: S
authors.lastname: Izuma
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Okamoto
authors.forename: Kiyo
authors.initials: K
authors.lastname: Torii
authors.forename: Sadamu
authors.initials: S
authors.lastname: Noda
mesh_terms: D000483:Alleles; D003062:Codon / Q000235:genetics; D004247:DNA / Q000235:genetics*; D005260:Female; D016158:Genes, p53 / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005833:Genital Neoplasms, Female / Q000235:genetics*; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics; D019014:fas Receptor / Q000235:genetics*
chemical_list: D003062:Codon; D019014:fas Receptor; D004247:DNA; D005982:Glutathione Transferase