The PDGF signaling pathway controls multiple steroid-producing lineages.
The platelet-derived growth factor (PDGF) signaling pathway regulates numerous lineages of mesenchymal cell origin during development and in the adult. The transcriptional targets of this pathway have been shown to be required in several PDGF-dependent processes, but the roles of these targets in specific tissues is just beginning to be identified. In this study, we show that five different PDGF target genes are essential for male and/or female fertility. Mutations in each of these five different genes lead to defects in the steroid-producing cells in the testis and/or ovary and altered hormone production, suggesting that the PDGF pathway controls steroidogenesis through these genes in both sexes. Furthermore, conditional mutations of both PDGF receptors revealed a requirement in steroid-producing cells in multiple organs, including the testis, ovary, and adrenal cortex. Therefore, PDGF signaling may constitute a common mechanism in the control of multiple steroidogenic lineages.
Schmahl
Jennifer
J
Program in Developmental Biology, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Rizzolo
Kamran
K
Soriano
Philippe
P
D000818:Animals; D002454:Cell Differentiation; D005260:Female; D005298:Fertility / Q000235:genetics*; D007985:Leydig Cells / Q000378:metabolism; D008297:Male; D051379:Mice; D010982:Platelet-Derived Growth Factor / Q000235:genetics* / Q000378:metabolism; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000235:genetics; D020797:Receptor, Platelet-Derived Growth Factor beta / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics; D013256:Steroids / Q000096:biosynthesis*; D013799:Theca Cells / Q000378:metabolism
D010982:Platelet-Derived Growth Factor; D013256:Steroids; D020796:Receptor, Platelet-Derived Growth Factor alpha; D020797:Receptor, Platelet-Derived Growth Factor beta