HMGA2, microRNAs, and stem cell aging.
Mammalian aging results from a replicative decline in the function of somatic stem cells and other self-renewing cells. Recent studies (Monzen et al., 2008; Nishino et al., 2008; Sanna et al., 2008; Weedon et al., 2008) link a chromatin-associated protein, HMGA2, to development, height, and mouse stem cell aging during late fetal development and young adulthood.
Hammond
Scott M
SM
Department of Cell and Developmental Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. hammond@med.unc.edu
Sharpless
Norman E
NE
D000818:Animals; D016922:Cellular Senescence; D025743:HMGA2 Protein / Q000378:metabolism*; D051379:Mice / Q000502:physiology*; D035683:MicroRNAs / Q000378:metabolism*; D013234:Stem Cells / Q000166:cytology*
D025743:HMGA2 Protein; D035683:MicroRNAs