title: Lipoprotein biogenesis in Gram-positive bacteria: knowing when to hold 'em, knowing when to fold 'em.
abstract: Gram-positive bacterial lipoproteins are a functionally diverse and important class of peripheral membrane proteins. Recent advances in molecular biology and the availability of whole genome sequence data have overturned many long-held assumptions about the export and processing of these proteins, most notably the recent discovery that not all lipoproteins are exported as unfolded substrates through the general secretion pathway. Here, we review recent discoveries concerning the export and processing of these proteins, their role in virulence in Gram-positive bacteria and their potential as vaccine candidates or targets for new antimicrobials.
authors.affiliation: School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK. m.hutchings@uea.ac.uk
authors.forename: Matthew I
authors.initials: MI
authors.lastname: Hutchings
authors.forename: Tracy
authors.initials: T
authors.lastname: Palmer
authors.forename: Dean J
authors.initials: DJ
authors.lastname: Harrington
authors.forename: Iain C
authors.initials: IC
authors.lastname: Sutcliffe
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D006094:Gram-Positive Bacteria / Q000378:metabolism* / Q000472:pathogenicity; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology; D006801:Humans; D008074:Lipoproteins / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D051379:Mice; D017510:Protein Folding; D021381:Protein Transport; D014774:Virulence
chemical_list: D001426:Bacterial Proteins; D008074:Lipoproteins