title: Synthesis and structure-activity studies of novel homomorpholine oxazolidinone antibacterial agents.
abstract: A novel series of oxazolidinones were synthesized in which the morpholine C-ring of linezolid was replaced with homomorpholine. In addition to investigating the effect of a homomorpholine C-ring on antibacterial activity, the effect of des-, mono-, di-, and tri-fluoro substitution on the phenyl B-ring was investigated as well. Various C-5 functional groups were also examined, including acetamides and triazoles and carboxamides.
authors.affiliation: Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA. ji-young.kim@pfizer.com
authors.forename: Ji-Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Frederick E
authors.initials: FE
authors.lastname: Boyer
authors.forename: Allison L
authors.initials: AL
authors.lastname: Choy
authors.forename: Michael D
authors.initials: MD
authors.lastname: Huband
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Pagano
authors.forename: J V N
authors.initials: JV
authors.lastname: Vara Prasad
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009025:Morpholines / Q000737:chemistry*; D023303:Oxazolidinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D009025:Morpholines; D023303:Oxazolidinones; C037574:morpholine