title: Pharmacokinetics and dialysate levels of daptomycin given intravenously in a peritoneal dialysis patient.
abstract: In this report we present pharmacokinetic (Pk) data of daptomycin given intravenously in a peritoneal dialysis patient. Daptomycin plasma levels were within therapeutic range; however, half-life of the drug was prolonged compared to haemodialysis. Both plasma and dialysate levels were found to be consistently above the minimal inhibitory concentration for daptomycin sensitive strains.
authors.affiliation: Department of Internal Medicine, Division of Nephrology and Hypertension.
authors.forename: Vega A
authors.initials: VA
authors.lastname: Goedecke
authors.forename: Christian
authors.initials: C
authors.lastname: Clajus
authors.forename: Olaf
authors.initials: O
authors.lastname: Burkhardt
authors.forename: Jens
authors.initials: J
authors.lastname: Martens-Lobenhoffer
authors.forename: Stefanie M
authors.initials: SM
authors.lastname: Bode-Boger
authors.forename: Jan T
authors.initials: JT
authors.lastname: Kielstein
authors.forename: Marcus
authors.initials: M
authors.lastname: Hiss
mesh_terms: D019540:Area Under Curve; D017576:Daptomycin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D015314:Dialysis Solutions / Q000032:analysis*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010530:Peritoneal Dialysis
chemical_list: D015314:Dialysis Solutions; D017576:Daptomycin