title: Gonadotropin-releasing hormone analog combined with a low-dose oral contraceptive to treat heavy menstrual bleeding.
abstract: OBJECTIVE
  To compare the effects of low-dose oral contraceptives used alone and in combination with a gonadotropin-releasing hormone (GnRH) analog to treat heavy menstrual bleeding.
  
  
  METHODS
  Fifty-eight patients with heavy menstrual bleeding were prospectively randomized into two treatment groups to receive either a low-dose oral contraceptive alone (group 1), or combined with a GnRH analog (group 2) for 6 months. The patients' hormonal profiles, and hemoglobin and hematocrit levels were measured at the beginning and at the end of the treatment period.
  
  
  RESULTS
  Hemoglobin and hematocrit levels significantly improved in both groups after 6 months of treatment (P<0.05 and P<0.01, respectively). Even in the first month of the study, the number of pads used and the duration of menstruation were significantly decreased in both groups and markedly lower in group 2 (P<0.01).
  
  
  CONCLUSIONS
  The addition of a GnRH analog to low-dose oral contraceptive treatment for heavy menstrual bleeding resulted in better control of vaginal bleeding, even in the first month of therapy.
authors.affiliation: Department of Obstetrics and Gynecology, Gazi University Faculty of Medicine, Ankara, Turkey.
authors.forename: Nadire N
authors.initials: NN
authors.lastname: Cetin
authors.forename: Onur
authors.initials: O
authors.lastname: Karabacak
authors.forename: Umit
authors.initials: U
authors.lastname: Korucuoglu
authors.forename: Nese
authors.initials: N
authors.lastname: Karabacak
mesh_terms: D000328:Adult; D003276:Contraceptives, Oral / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000627:therapeutic use*; D006801:Humans; D007273:Injections, Intramuscular; D008595:Menorrhagia / Q000188:drug therapy*; D008875:Middle Aged; D017060:Patient Satisfaction; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
chemical_list: D003276:Contraceptives, Oral; D007987:Gonadotropin-Releasing Hormone