Amlodipine: One of the main anti-hypertensive drugs in veterinary therapeutics.
Amlodipine is a dihydropyridine compound and belongs to the pharmacological family of calcium channel blockers. It is one of the main treatments of systemic arterial hypertension in cats and its validity has been confirmed in several reports. Its beneficial effect on the peripheral and coronary vascular bed is due to immediate vasodilation and to a delayed anti-hypertrophic action. The aim of the present review is to highlight the clinically-relevant characteristics of amlodipine, especially regarding its mechanism of action, and to present the main clinical reports supporting its interest in veterinary cardiology.
Tissier
Renaud
R
Unité de Pharmacie-Toxicologie, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort F-94704, France; INSERM U660, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort F-94704, France.
Perrot
Sebastien
S
Enriquez
Brigitte
B