title: A new therapeutic modality involving acridine orange excitation by photon energy used during reduction surgery for rhabdomyosarcomas.
abstract: Rhabdomyosarcoma is a common malignant soft tissue that frequently involves bone and major neurovascular structures and resection of deep-seated rhabdomyosarcoma can cause severe dysfunction in the affected limbs. Based on the mouse osteosarcoma model, we developed a new surgical approach involving photodynamic surgery (PDS), photodynamic therapy (PDT) and radiodynamic therapy (RDT) using acridine orange (AO). Six rhabdomyosarcoma cases were treated using this new modality after confirming the effectiveness of AO-PDT on human rhabdomyosarcoma cell lines. All patients had almost normal limb function after surgery, with only one recurrence. Based on these results, AO-PDS, PDT and RDT can be used to preserve excellent limb function in patients with rhabdomyosarcoma involving major nerves and vessels or bones.
authors.affiliation: Department of Orthopaedic Surgery, Mie Postgraduate School of Medicine, Mie Prefecture 514-8507, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Matsubara
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Kusuzaki
authors.forename: Akihiko
authors.initials: A
authors.lastname: Matsumine
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Murata
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Satonaka
authors.forename: Ken
authors.initials: K
authors.lastname: Shintani
authors.forename: Tomoki
authors.initials: T
authors.lastname: Nakamura
authors.forename: Hajime
authors.initials: H
authors.lastname: Hosoi
authors.forename: Tomoko
authors.initials: T
authors.lastname: Iehara
authors.forename: Toru
authors.initials: T
authors.lastname: Sugimoto
authors.forename: Atsumasa
authors.initials: A
authors.lastname: Uchida
mesh_terms: D000165:Acridine Orange / Q000627:therapeutic use*; D000293:Adolescent; D045744:Cell Line, Tumor; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010778:Photochemotherapy / Q000379:methods*; D017785:Photons / Q000627:therapeutic use*; D012208:Rhabdomyosarcoma / Q000473:pathology / Q000628:therapy*; D012983:Soft Tissue Neoplasms / Q000473:pathology / Q000628:therapy
chemical_list: D000165:Acridine Orange