title: Evidence for a role of the NOS1AP (CAPON) gene in schizophrenia and its clinical dimensions: an association study in a South American population isolate.
abstract: OBJECTIVE
  Recent studies have implicated a region on chromosome 1q21-23, including the NOS1AP gene, in susceptibility to schizophrenia. However, replication studies have been inconsistent, a fact that could partly relate to the marked psychopathological heterogeneity of schizophrenia. The aim of this study is to evaluate association of polymorphisms in the NOS1AP gene region to schizophrenia, in patients from a South American population isolate, and to assess if these variants are associated with specific clinical dimensions of the disorder.
  
  
  METHODS
  We genotyped 24 densely spaced SNPs in the NOS1AP gene region in a schizophrenia trio sample. The transmission disequilibrium test (TDT) was applied to single marker and haplotype data. Association to clinical dimensions (identified by factor analysis) was evaluated using a quantitative transmission disequilibrium test (QTDT).
  
  
  RESULTS
  We found significant association between eight SNPs in the NOS1AP gene region to schizophrenia (minimum p value = 0.004). The QTDT analysis of clinical dimensions revealed an association to a dimension consisting mainly of negative symptoms (minimum p value 0.001).
  
  
  CONCLUSIONS
  Our findings are consistent with a role for NOS1AP in susceptibility to schizophrenia, especially for the 'negative syndrome' of the disorder.
authors.affiliation: The Galton Laboratory, Department of Biology, University College London, London, UK.
authors.forename: Barbara
authors.initials: B
authors.lastname: Kremeyer
authors.forename: Jenny
authors.initials: J
authors.lastname: García
authors.forename: Hanna
authors.initials: H
authors.lastname: Kymäläinen
authors.forename: Naomi
authors.initials: N
authors.lastname: Wratten
authors.forename: Gabriel
authors.initials: G
authors.lastname: Restrepo
authors.forename: Carlos
authors.initials: C
authors.lastname: Palacio
authors.forename: Ana Lucía
authors.initials: AL
authors.lastname: Miranda
authors.forename: Carlos
authors.initials: C
authors.lastname: López
authors.forename: Margarita
authors.initials: M
authors.lastname: Restrepo
authors.forename: Gabriel
authors.initials: G
authors.lastname: Bedoya
authors.forename: Linda M
authors.initials: LM
authors.lastname: Brzustowicz
authors.forename: Jorge
authors.initials: J
authors.lastname: Ospina-Duque
authors.forename: María Patricia
authors.initials: MP
authors.lastname: Arbeláez
authors.forename: Andrés
authors.initials: A
authors.lastname: Ruiz-Linares
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000328:Adult; D001483:Base Sequence; D005163:Factor Analysis, Statistical; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*; D017422:Sequence Analysis, DNA; D013020:South America; D055815:Young Adult
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D005819:Genetic Markers; C488081:NOS1AP protein, human