title: The SCINEXA: a novel, validated score to simultaneously assess and differentiate between intrinsic and extrinsic skin ageing.
abstract: BACKGROUND
  Studies on the pathogenesis of skin ageing as well as efficacy testing of cosmetic and aesthetic measures to prevent or reverse skin ageing require - as an easy to use method - a validated non-invasive clinical score, which allows to simultaneously assess and differentiate between intrinsic (=chronological) and extrinsic (=photo-) skin ageing. Such an ideal score, however, does currently not exist.
  
  
  OBJECTIVE
  We developed a novel skin ageing score 'SCINEXA' comprising 5 items indicative of intrinsic and 18 items highly characteristic of extrinsic skin ageing. These items were used to define an index (index(discr)) that allowed differentiating between intrinsic versus extrinsic skin ageing. In order to validate the 'SCINEXA', we asked whether it can be used to discriminate regular sunbed users, which have been chronically exposed to ultraviolet radiation and thus are prone to photoageing, from non-sunbed users, which were considered paradigmatic for intrinsic skin ageing.
  
  
  METHODS
  For this purpose, 58 non-sunbed users and 16 regularly sunbed users were assessed. In addition to the clinical examination of the 23 score items potential confounders were considered by questionnaire.
  
  
  RESULTS
  By employing the index(discr), we were able to classify 92% of all study subjects correctly as sunbed or non-sunbed users. Specifically, an index above 2 was associated with sunbed use and thus extrinsic skin ageing, whereas an index below 2 indicated intrinsic skin ageing.
  
  
  CONCLUSIONS
  The novel 'SCINEXA' is suitable for the simultaneous assessment of intrinsic and extrinsic skin ageing.
authors.affiliation: Institut für Umweltmedizinische Forschung (IUF), Düsseldorf, Germany.
authors.forename: Andrea
authors.initials: A
authors.lastname: Vierkötter
authors.forename: Ulrich
authors.initials: U
authors.lastname: Ranft
authors.forename: Ursula
authors.initials: U
authors.lastname: Krämer
authors.forename: Dorothea
authors.initials: D
authors.lastname: Sugiri
authors.forename: Verena
authors.initials: V
authors.lastname: Reimann
authors.forename: Jean
authors.initials: J
authors.lastname: Krutmann
mesh_terms: D000328:Adult; D000368:Aged; D003625:Data Collection; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012107:Research Design / Q000706:statistics & numerical data*; D015595:Skin Aging / Q000528:radiation effects*; D055108:Sunbathing; D013472:Sunlight; D014466:Ultraviolet Rays