title: Adenocarcinoma following ileal pouch-anal anastomosis for ulcerative colitis: review of 26 cases.
abstract: The occurrence of adenocarcinoma following ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC) is an infrequent and but potentially lethal complication. We have seen 1 such case among 520 IPAAs performed in our group practice between 1978 and February 2008. We have added this case to a review of 25 previously reported cases of adenocarcinoma of the pouch or outflow tract following IPAA for UC. Our conclusions are 1) that post-IPAA cancer can occur following either mucosectomy or stapled anastomosis; 2) that this malignancy can occur after IPAA performed for UC either with or without neoplasia; and 3) that this complication is seen whether or not the initial cancer or dysplasia had involved the rectum.
authors.affiliation: Department of General Surgery, Mount Sinai School of Medicine, New York, New York 10029, USA.
authors.forename: Bernardino C
authors.initials: BC
authors.lastname: Branco
authors.forename: David B
authors.initials: DB
authors.lastname: Sachar
authors.forename: Tomas M
authors.initials: TM
authors.lastname: Heimann
authors.forename: Umut
authors.initials: U
authors.lastname: Sarpel
authors.forename: Noam
authors.initials: N
authors.lastname: Harpaz
authors.forename: Adrian J
authors.initials: AJ
authors.lastname: Greenstein
mesh_terms: D000230:Adenocarcinoma / Q000150:complications*; D000328:Adult; D000368:Aged; D000714:Anastomosis, Surgical / Q000009:adverse effects; D003093:Colitis, Ulcerative / Q000601:surgery*; D039021:Colonic Pouches / Q000009:adverse effects; D005260:Female; D006801:Humans; D007414:Intestinal Neoplasms / Q000150:complications*; D008297:Male; D008875:Middle Aged; D016737:Proctocolectomy, Restorative / Q000009:adverse effects*