Design and synthesis of a G-protein-coupled receptor antagonist library of aryloxyalkanolamines using a polymer-supported acyclic acetal linker.
A G-Protein-coupled receptor-targeted library of aryloxypropanolamines and aryloxybutanolamines was efficiently executed using a novel, polymer-supported acyclic acetal linker, producing compounds in good yields and purities.
Roberge
Jacques Y
JY
Bristol-Myers Squibb Company, R&D, Princeton, New Jersey 08543-4000, USA.
Harikrishnan
Lalgudi S
LS
Kamau
Muthoni G
MG
Ruan
Zheming
Z
Van Kirk
Katy
K
Liu
Yalei
Y
Cooper
Christopher B
CB
Poss
Michael A
MA
Dickson
John K
JK
Gavai
Ashvinikumar V
AV
Chao
Sam T
ST
Leith
Leslie W
LW
Bednarz
Mark S
MS
Mathur
Arvind
A
Kakarla
Ramesh
R
Schnur
Dora M
DM
Vaz
Roy
R
Lawrence
R Michael
RM
D000588:Amines / Q000138:chemical synthesis* / Q000494:pharmacology; D020650:Combinatorial Chemistry Techniques; D003432:Cross-Linking Reagents; D015195:Drug Design; D006801:Humans; D011108:Polymers; D011412:Propanolamines; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors*; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000494:pharmacology
D000588:Amines; D003432:Cross-Linking Reagents; D011108:Polymers; D011412:Propanolamines; D043562:Receptors, G-Protein-Coupled; D054852:Small Molecule Libraries