title: Multidetector computed tomography shows intramyocardial fat deposition.
abstract: BACKGROUND
  Intramyocardial fat deposition occurs as an age-related process and in multiple pathologic processes.
  
  
  OBJECTIVE
  We evaluated the presence of left ventricular (LV) and right ventricular (RV) intramyocardial fat with 64-slice multidetector computed tomography (MDCT).
  
  
  METHODS
  One hundred persons with no history of coronary artery disease (47 women, 53 men; mean age [+/- SD], 53 +/- 12.2 years) and 25 patients with CT findings of myocardial infarction (17 men, 8 women; mean age, 71.3 +/- 9.6 years) were studied for intramyocardial fat in defined segments of the ventricles (17 LV and 10 RV segments) at 3 levels. Fat deposition was defined as density range of -30 to -190 Hounsfield units on images both before and after contrast.
  
  
  RESULTS
  In healthy persons, LV intramyocardial fat was primarily located in the basal segments (5% anteroseptal, 5% inferior), and RV intramyocardial fat was primarily located in the anterolateral (24% of base, 23% of mid) and inferolateral (27% base, 27% mid) segments. Older age was associated with an increased odds of RV (sex-adjusted odds ratio [OR] per decade increment, 1.61; 95% confidence interval [CI], 1.11-2.33; P = 0.012) but not LV (OR, 0.97; 95% CI, 0.67-1.40; P = 0.85) intramyocardial fat. Compared with women, men had a lower risk of LV (95% CI, 0.1-0.64; P = 0.004) but not RV (95% CI, 0.35-1.87; P = 0.62) intramyocardial fat. Patients with old myocardial infarction (>3 years) had increased percentage of fat in infarcted left ventricles at all 3 levels (P <or= 0.004).
  
  
  CONCLUSIONS
  Intramyocardial fat can be detected by MDCT and is common in healthy and infarcted myocardium.
authors.affiliation: Department of Radiologic Sciences, University of California, Irvine, Orange, CA 92868-3298, USA.
authors.forename: Aidan R
authors.initials: AR
authors.lastname: Raney
authors.forename: Farhood
authors.initials: F
authors.lastname: Saremi
authors.forename: Satish
authors.initials: S
authors.lastname: Kenchaiah
authors.forename: Swaminatha V
authors.initials: SV
authors.lastname: Gurudevan
authors.forename: Jagat
authors.initials: J
authors.lastname: Narula
authors.forename: Navneet
authors.initials: N
authors.lastname: Narula
authors.forename: Stephanie
authors.initials: S
authors.lastname: Channual
mesh_terms: D000273:Adipose Tissue / Q000000981:diagnostic imaging*; D000368:Aged; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed / Q000379:methods*