Cardiac regeneration and stem cell therapy.
OBJECTIVE
Significant recent developments have occurred in the field of cardiac regeneration and stem-cell therapy. Understanding the new technological advances in cell therapy will ultimate allow us to achieve a goal of cell-based cardiac repair.


RESULTS
We discuss the latest cell-based therapies (including skeletal myoblasts, bone-marrow-derived cells, stem cells), the recent clinical trials in humans and different delivery techniques.


CONCLUSIONS
Ongoing unraveling of the mechanistic and clinical complexities underlying cardiac regeneration will advance the field of regenerative medicine. Substantial progress is being made by the parallel conduct of basic science studies and clinical trials that are incorporating mechanistic evaluations.
Hare
Joshua M
JM
Cardiovascular Division, University of Miami Miller School of Medicine, Miami, Florida 33101, USA. JHare@med.miami.edu
Chaparro
Sandra V
SV
D054058:Acute Coronary Syndrome / Q000503:physiopathology / Q000601:surgery; D000818:Animals; D016026:Bone Marrow Transplantation; D009202:Cardiomyopathies / Q000503:physiopathology / Q000601:surgery; D002986:Clinical Trials as Topic; D053595:Embryonic Stem Cells / Q000637:transplantation; D042783:Endothelial Cells / Q000637:transplantation; D006331:Heart Diseases / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D032448:Myoblasts, Skeletal / Q000637:transplantation; D017202:Myocardial Ischemia / Q000503:physiopathology / Q000601:surgery; D032383:Myocytes, Cardiac / Q000637:transplantation; D012038:Regeneration; D044968:Regenerative Medicine / Q000379:methods*; D013093:Spermatogonia / Q000637:transplantation; D033581:Stem Cell Transplantation; D016896:Treatment Outcome