title: Age related prostate-specific antigen reference range among men in south-East Caspian Sea.
abstract: The purpose of this study was to describe the distribution of serum prostate specific antigen (PSA) and to determine age-specific reference range in a population of Persian men. Venous blood samples were taken from 287 men, from Gorgan located in the North of Iran, South-East of Caspian Sea, aged 15 > or = 80 year. The serum PSA levels was measured using Enzyme-linked Immunosorbant-Assay (ELISA) technique and age-specific range for PSA level was determined. The serum prostate-specific antigen level for six age group of 15-40 years, 41-50 years, 51-60 years, 61-70 years, 71-80 years and >80 years were mainly in the range of 0-2.5 ng mL(-1), for 76.6%, 2.6-4 ng mL(-1) for 9.1% and as whole 85.7% of all men in this study had < or = 4 ng mL(-1), 8.7 and 5.6% all men of six age group had PSA level of 4.1-10 ng mL(-1) and >10 ng mL(-1), respectively. The findings of present study indicated that a large proportion (76.6%) men in this region have a lower PSA level of 0-2.5 ng mL(-1) and only 9.1% of men have PSA level of 2.6-4 ng mL(-1). It is therefore concluded that acceptable reference range of 0-4 ng mL(-1) for PSA level require further reassessment.
authors.affiliation: Department of Biochemistry, Golestan University of Medical Sciences, Gorgan, Iran.
authors.forename: A R
authors.initials: AR
authors.lastname: Mansourian
authors.forename: E O
authors.initials: EO
authors.lastname: Ghaemi
authors.forename: A R
authors.initials: AR
authors.lastname: Ahmadi
authors.forename: A
authors.initials: A
authors.lastname: Marjani
authors.forename: A
authors.initials: A
authors.lastname: Moradi
authors.forename: A
authors.initials: A
authors.lastname: Saifi
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood*; D012016:Reference Values; D055815:Young Adult
chemical_list: D017430:Prostate-Specific Antigen