Thrombin and brain recovery after intracerebral hemorrhage.
Intracerebral hemorrhage (ICH) is a common and often fatal subtype of stroke and produces severe neurological deficits in survivors. At present, there is lack of effective treatments that improve outcome in ICH. A neglected aspect of ICH research is the development of approaches that can be effectively used to improve recovery. Although previous studies have showed that thrombin induces blood-brain barrier leakage, brain edema, and neuronal death after ICH, our recent studies have shown that thrombin may have a role in brain recovery after ICH. An understanding of the mechanisms by which thrombin affects neurogenesis, angiogenesis, and plasticity may facilitate brain recovery after ICH.
Hua
Ya
Y
R5018 Biomedical Science Research Building, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA.
Keep
Richard F
RF
Gu
Yuxiang
Y
Xi
Guohua
G
D000818:Animals; D001921:Brain / Q000502:physiology*; D002543:Cerebral Hemorrhage / Q000503:physiopathology*; D004195:Disease Models, Animal; D006801:Humans; D018919:Neovascularization, Physiologic / Q000502:physiology; D055495:Neurogenesis / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology; D018179:Receptors, Thrombin / Q000502:physiology; D020127:Recovery of Function / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D013917:Thrombin / Q000502:physiology*
D018179:Receptors, Thrombin; D013917:Thrombin