title: Triple hybrids of steroids, spiroketals, and oligopeptides as new biomolecular chimeras.
abstract: An oxidative enol ether rearrangement was the key methodology in the construction of steroid-spiroketal-RGD peptides. Biological studies demonstrated potent integrin CD11b/CD18 antagonistic effects.
authors.affiliation: Department of Chemistry and Center for Chemical Methodologies & Library Development, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
authors.forename: Abhisek
authors.initials: A
authors.lastname: Banerjee
authors.forename: Eduard
authors.initials: E
authors.lastname: Sergienko
authors.forename: Stefan
authors.initials: S
authors.lastname: Vasile
authors.forename: Vineet
authors.initials: V
authors.lastname: Gupta
authors.forename: Kristiina
authors.initials: K
authors.lastname: Vuori
authors.forename: Peter
authors.initials: P
authors.lastname: Wipf
mesh_terms: D039481:CD11b Antigen / Q000378:metabolism; D018821:CD18 Antigens / Q000378:metabolism; D015394:Molecular Structure; D009842:Oligopeptides / Q000737:chemistry* / Q000494:pharmacology; D010084:Oxidation-Reduction; D013141:Spiro Compounds / Q000737:chemistry* / Q000494:pharmacology; D013237:Stereoisomerism; D013256:Steroids / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D039481:CD11b Antigen; D018821:CD18 Antigens; D009842:Oligopeptides; D013141:Spiro Compounds; D013256:Steroids