[High expression of proteasome subunit PSMA7 in colorectal cancer is significantly correlated with liver metastasis].
OBJECTIVE
To investigate the correlation between the proteasome subunit PSMA7 expression in colorectal cancer and its role in liver metastasis.


METHODS
To identify the PSMA7 protein expression in 62 primary site colorectal cancers, 34 lymph node metastatic sites and 13 liver metastatic sites by immunohistochemistry and clarify the correlation of its expression with the clinicopathological parameters.


RESULTS
High expression of PSMA7 was detected in 38.7% (24/62) of primary site colorectal cancer, 52.9% (18/34) of lymph node metastatic sites and 100% (13/13) liver metastatic sites but not in the normal colorectal tissue. High expression of PSMA7 was significantly correlated with liver metastasis (P = 0.028). The survival rate was significantly lower in patients with high expression of PSMA7 than in those with low expression of PSMA7 (P = 0.0008). As well, in multivariate analysis, PSMA7 expression demonstrated to be an independent prognostic factor (P = 0.004, relative risk 5.057; 95% confidence interval, 1.682-15.201).


CONCLUSIONS
PSMA7 may play an important role in the colorectal cancer progression. Evaluation of PSMA7 expression in primary colorectal cancer at the time of surgery might be a valuable test in defining patients with a high risk of developing liver metastasis.
Hu
Xiao-Tong
XT
Biomedical Research Center, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China.
Chen
Wei
W
Wang
Da
D
Shi
Qing-Lan
QL
Zhang
Fu-Biao
FB
Liao
Yong-Qiang
YQ
Jin
Mei
M
He
Chao
C
D000328:Adult; D000368:Aged; D003110:Colonic Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008113:Liver Neoplasms / Q000201:enzymology / Q000556:secondary*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D012004:Rectal Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D015996:Survival Rate; D055815:Young Adult
C488662:PSMA7 protein, human; D046988:Proteasome Endopeptidase Complex