Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control.
New studies have revealed an essential role for TRPA1, a sensory neuronal TRP ion channel, in airway chemosensation and inflammation. TRPA1 is activated by chlorine, reactive oxygen species, and noxious constituents of smoke and smog, initiating irritation and airway reflex responses. Together with TRPV1, the capsaicin receptor, TRPA1 may contribute to chemical hypersensitivity, chronic cough, and airway inflammation in asthma, COPD, and reactive airway dysfunction syndrome.
Bessac
Bret F
BF
Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, USA.
Jordt
Sven-Eric
SE
D000818:Animals; D015220:Calcium Channels / Q000235:genetics / Q000502:physiology*; D003371:Cough / Q000503:physiopathology*; D006801:Humans; D018777:Multiple Chemical Sensitivity / Q000235:genetics / Q000503:physiopathology*; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology*; D018384:Oxidative Stress / Q000502:physiology; D012018:Reflex / Q000502:physiology; D000074025:TRPA1 Cation Channel; D050916:TRPV Cation Channels / Q000235:genetics / Q000502:physiology*; D050051:Transient Receptor Potential Channels / Q000235:genetics / Q000502:physiology*
D015220:Calcium Channels; D009419:Nerve Tissue Proteins; D000074025:TRPA1 Cation Channel; C473350:TRPA1 protein, human; D050916:TRPV Cation Channels; C494482:TRPV1 protein, human; D050051:Transient Receptor Potential Channels