title: Nerve fiber impairment of anterior thalamocortical circuitry in juvenile myoclonic epilepsy.
abstract: BACKGROUND
  Juvenile myoclonic epilepsy (JME) is a syndrome of idiopathic generalized epilepsy (IGE) without structural brain abnormalities detectable by MRI or CT.
  
  
  OBJECTIVE
  In the present study, we addressed the question of whether diffusion tensor MRI (DTI) can detect disease-specific white matter (WM) abnormalities in patients with JME.
  
  
  METHODS
  We performed whole head DTI at 3 T in 10 patients with JME, 8 age-matched patients with cryptogenic partial epilepsy (CPE), and 67 age-matched healthy volunteers. Nerve fiber integrity was compared between the groups on the basis of optimized voxel-by-voxel statistics of fractional anisotropy (FA) maps obtained by DTI (analysis of covariance, categorical factor "group," covariate "age").
  
  
  RESULTS
  FA was reduced in a WM region associated with the anterior thalamus and prefrontal cortex in patients with JME compared to both control subjects and patients with CPE (p < 0.001). The patients with CPE showed normal values in this particular WM region. The FA reductions in the patients with JME correlated with the frequency of generalized tonic-clonic seizures (Spearman R = 0.54, p = 0.05). No significant correlations were found in the JME sample between FA reduction and the duration of antiepileptic medication.
  
  
  CONCLUSIONS
  The results support the hypothesis that juvenile myoclonic epilepsy is associated with abnormalities of the thalamocortical network that can be detected by diffusion tensor MRI.
authors.affiliation: Department of Neurology, University of Muenster, Albert-Schweitzer-Str. 33, 48129 Muenster, Germany. mail@Michael-Deppe.de
authors.forename: M
authors.initials: M
authors.lastname: Deppe
authors.forename: C
authors.initials: C
authors.lastname: Kellinghaus
authors.forename: T
authors.initials: T
authors.lastname: Duning
authors.forename: G
authors.initials: G
authors.lastname: Möddel
authors.forename: S
authors.initials: S
authors.lastname: Mohammadi
authors.forename: K
authors.initials: K
authors.lastname: Deppe
authors.forename: H
authors.initials: H
authors.lastname: Schiffbauer
authors.forename: H
authors.initials: H
authors.lastname: Kugel
authors.forename: S S
authors.initials: SS
authors.lastname: Keller
authors.forename: E B
authors.initials: EB
authors.lastname: Ringelstein
authors.forename: S
authors.initials: S
authors.lastname: Knecht
mesh_terms: D000328:Adult; D016880:Anisotropy; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology* / Q000503:physiopathology; D003072:Cognition Disorders / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D038524:Diffusion Magnetic Resonance Imaging; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D020190:Myoclonic Epilepsy, Juvenile / Q000473:pathology* / Q000503:physiopathology; D009413:Nerve Fibers, Myelinated / Q000378:metabolism / Q000473:pathology*; D009415:Nerve Net / Q000473:pathology / Q000503:physiopathology; D009434:Neural Pathways / Q000473:pathology / Q000503:physiopathology; D011237:Predictive Value of Tests; D017397:Prefrontal Cortex / Q000473:pathology / Q000503:physiopathology; D012640:Seizures / Q000473:pathology / Q000503:physiopathology; D013788:Thalamus / Q000473:pathology* / Q000503:physiopathology; D014855:Wallerian Degeneration / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D055815:Young Adult