title: Collateral damage from antigen receptor gene diversification.
abstract: Chromosomal translocations that juxtapose antigen receptor genes and oncogenes are frequently associated with lymphoid malignancies. In this issue, Robbiani et al. (2008) show that activation-induced deaminase (AID), an enzyme involved in antigen receptor gene diversification, generates DNA double-strand breaks (DSBs) in oncogenes, and Tsai et al. (2008) propose that AID and the recombinase-activating gene (RAG) endonuclease may collaborate to generate off-target DSBs.
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: Grace K
authors.initials: GK
authors.lastname: Mahowald
authors.forename: Jason M
authors.initials: JM
authors.lastname: Baron
authors.forename: Barry P
authors.initials: BP
authors.lastname: Sleckman
mesh_terms: D000818:Animals; D003564:Cytidine Deaminase / Q000378:metabolism*; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair; D018398:Homeodomain Proteins / Q000378:metabolism; D006801:Humans; D008223:Lymphoma / Q000235:genetics / Q000378:metabolism; D011946:Receptors, Antigen / Q000235:genetics* / Q000378:metabolism; D014178:Translocation, Genetic; D000098830:AICDA (Activation-Induced Cytidine Deaminase)
chemical_list: D018398:Homeodomain Proteins; D011946:Receptors, Antigen; C064658:RAG-1 protein; D000098830:AICDA (Activation-Induced Cytidine Deaminase); D003564:Cytidine Deaminase