Schistosomiasis haematobia: histopathological course determined by cystoscopy in a patient in whom praziquantel treatment failed.
Schistosomiasis haematobia or urinary schistosomiasis is one of the main public health problems in Africa and the Middle East. A single dose of 40 mg praziquantel per kg body weight continues to be the treatment of choice for this infection. The aims of this follow-up were to study the post-treatment course of a patient infected with S. haematobium and not submitted to re-exposure, and to identify complications of the disease and/or therapeutic failure after praziquantel treatment by histopathological analysis. Treatments were repeated under medical supervision to ensure the correct use of the drug. In view of the suspicion of lesions in cystoscopy, the patient was submitted to bladder biopsy. The histopathological characteristics observed in biopsies obtained, after each treatment, indicated viability of parasite eggs and activity of granulomas.
Silva
Iran Mendonça da
IM
Seção de Vigilância Epidemiológica, Subdivisão de Pesquisa, Divisão de Ensino e Pesquisa, Instituto de Biologia do Exército, Rio de Janeiro, RJ, Brasil.
Pereira Filho
Edson
E
Thiengo
Roberto
R
Ribeiro
Paulo César
PC
Conceição
Maria José
MJ
Panasco
Mônica
M
Lenzi
Henrique Leonel
HL
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D001706:Biopsy; D003558:Cystoscopy; D006099:Granuloma / Q000469:parasitology / Q000473:pathology; D006801:Humans; D008297:Male; D010270:Parasite Egg Count; D011223:Praziquantel / Q000627:therapeutic use*; D012548:Schistosoma haematobium / Q000302:isolation & purification*; D012553:Schistosomiasis haematobia / Q000188:drug therapy / Q000473:pathology* / Q000652:urine; D017211:Treatment Failure; D001743:Urinary Bladder / Q000469:parasitology* / Q000473:pathology
D000871:Anthelmintics; D011223:Praziquantel