title: Assessment of a self-deferral form for screening blood donors, Chiang Mai University Hospital, Thailand.
abstract: A self-deferral form has been used to screen Chiang Mai University Hospital blood donors and was improved in 2005. It has never been evaluated. The study aimed to assess the self-deferral form procedures in detecting infected donors. Sera from 5,083 donors, who passed the self-deferral screening form, were tested with the routine immuno-assays (serology) for HIV 1 and 2 antibodies, P24 antigen, HCV antibodies, HBV surface antigen, and syphilis. Antibody negative sera were also tested individually with the the Procleix Ultrio Assay for HIV-1 DNA, HCV RNA, and HBV DNA. The donors who had discrepant results between serology and NAT were evaluated with additional tests, including a more sensitive Alternative Nucleic Acid Test, AntiBcore IgM, AntiBcore IgG, HBsAg and Anti HBs. Among 5,083 donors, 331 (6.5%) had at least one positive marker. In multiple logistic regression analysis, the statistically significant factors (adjusted odds ratio and 95% CI) for infection were age 30 years or below [1.45 (1.03, 2.03)], male gender [2.73 (1.64, 4.56)], primary school or lower education [1.56 (1.09, 2.23)], first-time donation [1.82 (1.25, 2.67)], and frequent donation [0.80 (0.70, 0.92)]. The safest donors were females, older than 30 years, with an education more than primary school, and frequent donation. Because of missing responses to some sensitive questions, there remains a need for further improvement of the self-deferral form.
authors.affiliation: Department of Community Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. lthaikru@mail.med.cmu.ac.th
authors.forename: Lakkana
authors.initials: L
authors.lastname: Thaikruea
authors.forename: Niwes
authors.initials: N
authors.lastname: Nantachit
authors.forename: Nipapan
authors.initials: N
authors.lastname: Leetrakool
authors.forename: Ladda
authors.initials: L
authors.lastname: Fongsatitkul
authors.forename: Prakai
authors.initials: P
authors.lastname: Sompan
authors.forename: Andrew
authors.initials: A
authors.lastname: Heaton
authors.forename: Kenrad E
authors.initials: KE
authors.lastname: Nelson
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001782:Blood Donors; D005260:Female; D016655:HIV Core Protein p24 / Q000097:blood; D015497:HIV-1 / Q000302:isolation & purification; D015498:HIV-2 / Q000302:isolation & purification; D006514:Hepatitis B Surface Antigens / Q000097:blood; D018937:Hepatitis C Antibodies / Q000097:blood; D006785:Hospitals, University; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D012737:Sex Factors; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D013587:Syphilis / Q000097:blood; D013785:Thailand; D055815:Young Adult
chemical_list: D016655:HIV Core Protein p24; D006514:Hepatitis B Surface Antigens; D018937:Hepatitis C Antibodies