title: Cytomegalovirus encephalitis/retinitis in allogeneic haematopoietic stem cell transplant recipient treated successfully with combination of cidofovir and foscarnet.
abstract: We report an 18-yr-old female patient with repeated CMV reactivations after HSCT treated by several pre-emptive courses of virostatic therapy. Seven months after HSCT, she developed CMV encephalitis/retinitis. Initial therapy with GCV and hyperimmune globulin failed, and later on GCV-resistant strain was detected. Continual increase of CMV DNA in peripheral blood led us to combined therapy with CDV and FCV, which was successful and free of severe renal toxicity. To our best knowledge, this is the first reported case of successful CMV treatment with a combination of CDV and FCV.
authors.affiliation: Motol University Hospital, Prague, Czech Republic. petr.hubacek@lfmotol.cuni.cz
authors.forename: Petr
authors.initials: P
authors.lastname: Hubacek
authors.forename: Petra
authors.initials: P
authors.lastname: Keslova
authors.forename: Renata
authors.initials: R
authors.lastname: Formankova
authors.forename: Pavel
authors.initials: P
authors.lastname: Pochop
authors.forename: Ondrej
authors.initials: O
authors.lastname: Cinek
authors.forename: Miroslav
authors.initials: M
authors.lastname: Zajac
authors.forename: Jana
authors.initials: J
authors.lastname: Lochmanova
authors.forename: Jan
authors.initials: J
authors.lastname: Stary
authors.forename: Petr
authors.initials: P
authors.lastname: Sedlacek
mesh_terms: D000293:Adolescent; D000998:Antiviral Agents / Q000627:therapeutic use*; D000077404:Cidofovir; D003586:Cytomegalovirus Infections / Q000150:complications / Q000188:drug therapy* / Q000209:etiology*; D003596:Cytosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D018792:Encephalitis, Viral / Q000150:complications / Q000188:drug therapy* / Q000209:etiology*; D005260:Female; D017245:Foscarnet / Q000627:therapeutic use*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000628:therapy; D063065:Organophosphonates / Q000627:therapeutic use*; D012173:Retinitis / Q000150:complications / Q000188:drug therapy* / Q000209:etiology*; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; D017245:Foscarnet; D003596:Cytosine; D000077404:Cidofovir