[Rhizoma Panacis majori reduces toxicity of chemotherapy in S180-bearing mice].
OBJECTIVE
To observe the attenuating effect of Rhizoma Panacis majoris (RPM) on toxicity of 5-fluorouracil (5-FU) chemotherapy in S180-bearing mice.


METHODS
S180 cells were subcutaneously injected to the right armpit of the mice to establish the S180-bearing model, and thirty mice were randomly divided into untreated group, 5-FU group and 5-FU combined with RPM group (5-FU plus RPM group). The general condition of S180-bearing mice was observed. The white blood cells, red blood cells, and reticulocytes in the peripheral blood were counted, and the ratio of reticulocytes was measured too. The life-span of the S180-bearing mice was recorded.


RESULTS
The white blood cell count and the ratio of reticulocytes in 5-FU plus RPM group were higher than those in 5-FU group (P<0.01). The average lifespan of 5-FU plus RPM group was 32.5 days and that of the 5-FU group was 23.5 days; there was a significant difference in the lifespan between the two groups (P<0.01).


CONCLUSIONS
RPM can reduce the toxic effect of 5-FU and prolong the lifespan of S180-bearing mice.
Chen
Tao
T
Department of Traditional Chinese Medicine, Medical College of Three Gorges University, Yichang, Hubei Province 443002, China. chentao@ctgu.edu.cn
Gong
Zhang-bin
ZB
Fu
Ya-ling
YL
D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000633:toxicity*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D005472:Fluorouracil / Q000633:toxicity*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012510:Sarcoma 180 / Q000188:drug therapy
D000964:Antimetabolites, Antineoplastic; D004365:Drugs, Chinese Herbal; D005472:Fluorouracil