title: Right into the heart of microRNA-133a.
abstract: MicroRNAs play an essential role in diverse cellular processes, such as proliferation, differentiation, apoptosis, and stress response. Recent studies demonstrate that miRNAs are important for timing developmental decisions and fine-tuning cellular determination in vertebrate heart development. In an elegant set of experiments reported in this issue of Genes & Development, Liu et al. (3242-3254) demonstrate that miR-133a functions as an inhibitor of cardiomyocyte proliferation and a modifier of serum response factor (SRF)-dependent transcriptional signaling in the murine heart. Both targeted deletion and transgenic overexpression of miR-133a can result in the same cardiac phenotype, ventricular septal defect (VSD) and heart failure. The new data add another piece to the puzzle of regulatory networks that are implicated in cardiac disease. It will be interesting to see, if miR-133a is also involved in human heart diseases, especially VSD and dilated cardiomyopathy.
authors.affiliation: Department of Medicine III, University of Heidelberg, Heidelberg 69120, Germany.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Meder
authors.forename: Hugo A
authors.initials: HA
authors.lastname: Katus
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Rottbauer
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D056742:Cyclin D2; D016213:Cyclins / Q000378:metabolism; D006321:Heart / Q000502:physiology*; D006330:Heart Defects, Congenital / Q000378:metabolism; D006331:Heart Diseases / Q000378:metabolism*; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000235:genetics / Q000502:physiology*; D026362:Serum Response Factor / Q000378:metabolism; D015398:Signal Transduction
chemical_list: C486196:Ccnd2 protein, mouse; D056742:Cyclin D2; D016213:Cyclins; D035683:MicroRNAs; C517732:Mirn133 microRNA, mouse; D026362:Serum Response Factor