title: A population-based survey to assess troublesome symptoms in gastroesophageal reflux disease.
abstract: OBJECTIVE
  A simple frequency and severity threshold for categorizing reflux symptoms as troublesome has been suggested, but there is a lack of confirmatory studies for this threshold. The objectives of this study were to examine the characteristics for troublesome symptoms and to compare different ways of categorizing reflux symptoms as troublesome.
  
  
  METHODS
  Members of a web panel responding to an e-mail invitation (1623/3506, median age interval 40-44 years, 51% female) who reported reflux symptoms during the preceding 4 weeks (n=1284) were linked to the full questionnaire. Associations between self-reported troublesome symptoms (10-graded VAS) and troublesome symptoms (mild symptoms >1 day/week or moderate/severe symptoms > or = 1 day/week) and clinical characteristics were analyzed.
  
  
  RESULTS
  Out of 1284 subjects, 482 (38%) reported reflux symptoms. Agreement on the classification of troublesome symptoms based on frequency and severity and self-reported troublesome symptoms was poor to fair. Using 4 as the cut-off point on the VAS showed the best agreement (kappa = 0.35). Of the 482 symptomatic respondents, 266 (55%) had troublesome symptoms based on frequency and severity and 274 (57%) had self-reported troublesome symptoms. Subjects (n=80) who had self-reported troublesome symptoms, but were not categorized as having troublesome symptoms based on frequency and severity, reported health concerns, work productivity loss and medical treatment significantly more often (p< or =0.03) than subjects (n=194) with troublesome symptoms according to both categorizations.
  
  
  CONCLUSIONS
  Classification of troublesome reflux symptoms based on frequency and severity is too simplistic. Health concerns, disrupted work productivity and night-time symptoms add to the perception of symptoms as troublesome.
authors.affiliation: Department of Medical Gastroenterology, Køge University Hospital, Denmark. peter.bytzer@dadlnet.dk
authors.forename: Christina
authors.initials: C
authors.lastname: Reimer
authors.forename: Peter
authors.initials: P
authors.lastname: Bytzer
mesh_terms: D000041:Absenteeism; D000293:Adolescent; D000328:Adult; D000863:Antacids / Q000627:therapeutic use; D017281:Cost of Illness; D003718:Denmark; D004526:Efficiency; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000453:epidemiology* / Q000523:psychology; D006306:Health Surveys; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D000863:Antacids; D054328:Proton Pump Inhibitors