title: Detection of isolated cerebrovascular beta-amyloid with Pittsburgh compound B.
abstract: Imaging of cerebrovascular beta-amyloid (cerebral amyloid angiopathy) is complicated by the nearly universal overlap of this pathology with Alzheimer's pathology. We performed positron emission tomographic imaging with Pittsburgh Compound B on 42-year-old man with early manifestations of Iowa-type hereditary cerebral amyloid angiopathy, a form of the disorder with little or no plaque deposits of fibrillar beta-amyloid. The results demonstrated increased Pittsburgh Compound B retention selectively in occipital cortex, sparing regions typically labeled in Alzheimer's disease. These results offer compelling evidence that Pittsburgh Compound B positron emission tomography can noninvasively detect isolated cerebral amyloid angiopathy before overt signs of tissue damage such as hemorrhage or white matter lesions.
authors.affiliation: Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. sgreenberg@partners.org
authors.forename: Steven M
authors.initials: SM
authors.lastname: Greenberg
authors.forename: Thomas
authors.initials: T
authors.lastname: Grabowski
authors.forename: M Edip
authors.initials: ME
authors.lastname: Gurol
authors.forename: Maureen E
authors.initials: ME
authors.lastname: Skehan
authors.forename: R N Kaveer
authors.initials: RN
authors.lastname: Nandigam
authors.forename: John A
authors.initials: JA
authors.lastname: Becker
authors.forename: Monica
authors.initials: M
authors.lastname: Garcia-Alloza
authors.forename: Claudia
authors.initials: C
authors.lastname: Prada
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Frosch
authors.forename: Jonathan
authors.initials: J
authors.lastname: Rosand
authors.forename: Anand
authors.initials: A
authors.lastname: Viswanathan
authors.forename: Eric E
authors.initials: EE
authors.lastname: Smith
authors.forename: Keith A
authors.initials: KA
authors.lastname: Johnson
mesh_terms: D000328:Adult; D016229:Amyloid beta-Peptides / Q000032:analysis*; D000814:Aniline Compounds; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000503:physiopathology; D001931:Brain Mapping / Q000379:methods; D016657:Cerebral Amyloid Angiopathy / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000503:physiopathology; D002536:Cerebral Arteries / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008297:Male; D009778:Occipital Lobe / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D058225:Plaque, Amyloid / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D049268:Positron-Emission Tomography / Q000379:methods; D011237:Predictive Value of Tests; D013844:Thiazoles
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D016229:Amyloid beta-Peptides; D000814:Aniline Compounds; D013844:Thiazoles