Resolving resolvases: the final act?
The Holliday junction (HJ) is a central intermediate in homologous recombination. Ip et al. (2008), in a recent issue of Nature, have identified a new subclass of the Rad2/XPG family of nucleases with the hallmark of symmetrical cleavage of HJ substrates to produce nicked duplex products.
Symington
Lorraine S
LS
Department of Microbiology, Columbia University College of Physicians and Surgeons, 701 168th Street, New York, NY 10032, USA. lss5@columbia.edu
Holloman
William K
WK
D045566:DNA, Cruciform / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D045522:Recombinases / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000201:enzymology
D045566:DNA, Cruciform; D045522:Recombinases