Cytotoxic benzil and coumestan derivatives from Tephrosia calophylla.
A benzil, calophione A, 1-(6'-Hydroxy-1',3'-benzodioxol-5'-yl)-2-(6''-hydroxy-2''-isopropenyl-2'',3''-dihydro-benzofuran-5''-yl)-ethane-1,2-dione and three coumestan derivatives, tephcalostan B, C and D were isolated from the roots of Tephrosia calophylla. Their structures were deduced from spectroscopic data, including 2D NMR (1)H-(1)H COSY and (13)C-(1)H COSY experiments. Compounds were evaluated for cytotoxicity against RAW (mouse macrophage cells) and HT-29 (colon cancer cells) cancer cell lines and antiprotozoal activity against various parasitic protozoa. Calophione A exhibited significant cytotoxicity with IC(50) of 5.00 (RAW) and 2.90microM (HT-29), respectively.
Ganapaty
Seru
S
Pharmacognosy and Phytochemistry Division, Department of Pharmaceutical, Sciences, Andhra University, Visakhapatnam 530 003, Andhra Pradesh, India. ganapatyseru@gmail.com
Srilakshmi
Guttula Veera Kantha
GV
Pannakal
Steve Thomas
ST
Rahman
Hafizur
H
Laatsch
Hartmut
H
Brun
Reto
R
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D001565:Benzoates / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003374:Coumarins / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D031304:Tephrosia / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D001565:Benzoates; D003374:Coumarins