Influence of donor cocaine use on outcome after cardiac transplantation: analysis of the United Network for Organ Sharing Thoracic Registry.
Heart transplantation from donors with a history of cocaine abuse remains controversial. Therefore, we examined the consequence of donor cocaine-use history on all-cause mortality and the development of coronary artery disease after heart transplantation. Using the United Network for Organ Sharing Thoracic Registry we identified 9,217 first-time heart-only adult transplant recipients between January 1999 and December 2003, and then divided this cohort into sub-groups based on the reported history of donor cocaine use. Multivariate analysis revealed no difference in mortality or development of coronary artery disease at 1 and 5 years between transplant recipients who received an organ from donors with a history of cocaine use when compared with donors having no history of cocaine use.
Brieke
Andreas
A
Division of Cardiology, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045, USA. andreas.brieke@uchsc.edu
Krishnamani
Rajan
R
Rocha
Michael J
MJ
Li
Wenjun
W
Patten
Richard D
RD
Konstam
Marvin A
MA
Patel
Ayan R
AR
Udelson
James E
JE
Denofrio
David
D
D000328:Adult; D019970:Cocaine-Related Disorders / Q000150:complications*; D005500:Follow-Up Studies; D016027:Heart Transplantation / Q000401:mortality / Q000502:physiology*; D006801:Humans; D016016:Proportional Hazards Models; D012042:Registries; D012189:Retrospective Studies; D018570:Risk Assessment; D015996:Survival Rate; D014019:Tissue Donors