Effects of catalpol on mitochondrial function and working memory in mice after lipopolysaccharide-induced acute systemic inflammation.
The aim of this study was to investigate whether catalpol could facilitate recovery from lipopolysaccharide (LPS)-induced cognitive deficits and protect brain mitochondrial function from LPS-induced acute systemic inflammation. In the study, except control group, mice were challenged with a single dose of LPS (100 microg/mouse, i.p.) to mimic an acute peripheral infection. The results showed that LPS enhanced nuclear factor kappa B (NF-kappaB) activation and induced a loss in mitochondrial integrity as shown by a significant decrease in membrane potential and increase in mitochondrial permeability transition pore opening. Pretreatment with catalpol (10 mg/kg d, i.p.) for 10d before injection of LPS reversed the memory deficits induced by LPS, protected brain mitochondrial function, and attenuated LPS-induced NF-kappaB activation. Taken together, these data indicate that catalpol may possess therapeutic potential against LPS-induced acute systemic inflammation by attenuating NF-kappaB activation and protecting mitochondrial function in cerebral cortex and hippocampus.
Zhang
Aihong
A
School of Environmental and Biological Science and Technology, Dalian University of Technology, Dalian, Liaoning, China.
Hao
Shuang
S
Bi
Jing
J
Bao
Yongming
Y
Zhang
Xiuli
X
An
Lijia
L
Jiang
Bo
B
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D005960:Glucosides / Q000494:pharmacology*; D007249:Inflammation / Q000139:chemically induced; D057888:Iridoid Glucosides; D039823:Iridoids / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000633:toxicity; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008928:Mitochondria / Q000187:drug effects*; D016328:NF-kappa B / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D005960:Glucosides; D057888:Iridoid Glucosides; D039823:Iridoids; D008070:Lipopolysaccharides; D016328:NF-kappa B; C078040:catalpol