Invitro evaluation of the neutralising capacity of twenty brands of antacids in Lagos, Nigeria.
BACKGROUND
The use of substandard drugs is a great threat to the lives of people in the community. Identification of substandard drugs is important to exclude their use in clinical practice. These drugs may lead to reduced efficacy of pharmacotherapy. Antacid preparations are weakly basic and consist of metal salts, most commonly aluminium hydroxide or magnesium hydroxide. These salts dissociate to neutralise gastric acid and form neutral salts. The ultimate goal of antacid therapy is to reduce the concentration and the total load of acid in gastric juice with a pH of 1.3 to a pH between 3.5 and 5.0.


OBJECTIVE
The aim of this work is to carry out an in-vitro test on the acid neutralising capacity (ANC) of commonly available antacid brands in Lagos market.


METHODS
The British pharmacopoeia (BP) method of analysis of antacids was adopted. Twenty different brands of antacid suspensions and tablets were analysed.


RESULTS
Brand SH suspension gave the highest neutralising capacity, 101.65 ml +/- 0.15, while brand SN gave the lowest, 99.75 ml +/- 0.75. All the fourteen antacid suspensions analysed complied with the official specification and therefore passed the analysis. Brand TB tablet gave the highest acid neutralising capacity (ANC), 54.10 ml +/- 0.2 while brand TD 49.50 ml +/- 0.1 gave the lowest. All the six antacid tablet brands analysed passed the assay. The ANC of an antacid is a parameter used to measure the effectiveness of an antacid in relieving ulcer pain.


CONCLUSIONS
The acid-neutralising capacity of the antacid brands analysed were within the BP specification. The acid neutralising capacity of antacids should be determined before administration.
Adepoju-Bello
A A
AA
Pharmaceutical Chemistry, Dept., Faculty of Pharmacy, University of Lagos, Idi-araba, Lagos, Nigeria.
Akpabio
U E
UE
Ayoola
G A
GA
Coker
H A B
HA
Enwuru
N V
NV
D000863:Antacids / Q000737:chemistry* / Q000494:pharmacology* / Q000592:standards; D005744:Gastric Acid / Q000737:chemistry*; D009549:Nigeria
D000863:Antacids