Triple hybrids of steroids, spiroketals, and oligopeptides as new biomolecular chimeras.
An oxidative enol ether rearrangement was the key methodology in the construction of steroid-spiroketal-RGD peptides. Biological studies demonstrated potent integrin CD11b/CD18 antagonistic effects.
Banerjee
Abhisek
A
Department of Chemistry and Center for Chemical Methodologies & Library Development, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
Sergienko
Eduard
E
Vasile
Stefan
S
Gupta
Vineet
V
Vuori
Kristiina
K
Wipf
Peter
P
D039481:CD11b Antigen / Q000378:metabolism; D018821:CD18 Antigens / Q000378:metabolism; D015394:Molecular Structure; D009842:Oligopeptides / Q000737:chemistry* / Q000494:pharmacology; D010084:Oxidation-Reduction; D013141:Spiro Compounds / Q000737:chemistry* / Q000494:pharmacology; D013237:Stereoisomerism; D013256:Steroids / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D039481:CD11b Antigen; D018821:CD18 Antigens; D009842:Oligopeptides; D013141:Spiro Compounds; D013256:Steroids