Artificial membrane models for the study of macromolecular delivery.
Artificial biomembrane mimetic model systems are used to characterize peptide-membrane interactions using a wide range of methods. Herein, we present the use of selected membrane model systems to investigate peptide-membrane interactions. We describe methods for the preparation of various membrane mimetic media. Our applications will focus on small unilamellar vesicles (SUVs) and large unilamellar vesicles (LUVs) as well as on media more suited for nuclear magnetic resonance (NMR) techniques, micelles, and fast-tumbling two-component bilayered micelles (bicelles).
Mäler
Lena
L
Center for Biomembrane Research, Department of Biochemistry and Biophysics, Stockholm University, SE-106 91 Stockholm, Sweden.
Gräslund
Astrid
A
D009682:Magnetic Resonance Spectroscopy; D008567:Membranes, Artificial; D008823:Micelles; D008954:Models, Biological; D010455:Peptides / Q000378:metabolism*
D008567:Membranes, Artificial; D008823:Micelles; D010455:Peptides