Location, location, location: B-cell differentiation in the gut lamina propria.
The intestinal immune system includes an immunoglobulin (Ig)A-inductive site represented by Peyer's patches (PPs) and an IgA effector site represented by the lamina propria (LP). This canonical map of intestinal IgA production has been blurred recently by studies showing the presence of active IgA class switching in the LP. Here we discuss the functional implications and controversial nature of these findings.
Cerutti
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Department of Pathology and Laboratory Medicine, Weill Medical College, Cornell University, New York, New York, USA. acerutti@med.cornell.edu
D000818:Animals; D000917:Antibody Formation / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology*; D006801:Humans; D018928:Immunity, Mucosal / Q000276:immunology*; D007070:Immunoglobulin A / Q000276:immunology*; D007413:Intestinal Mucosa / Q000276:immunology / Q000382:microbiology; D008221:Lymphoid Tissue / Q000033:anatomy & histology / Q000276:immunology*; D009092:Mucous Membrane / Q000033:anatomy & histology / Q000276:immunology*; D010581:Peyer's Patches / Q000276:immunology*; D010950:Plasma Cells / Q000276:immunology*; D054448:Precursor Cells, B-Lymphoid / Q000276:immunology*; D009626:Terminology as Topic
D007070:Immunoglobulin A