Does low molecular weight heparin impair anastomotic wound healing?
BACKGROUND
Enoxaparin is an important molecule which had been using in prophylaxis and treatment of deep venous thrombosis. Also, it is showed that it prevents postsurgical peritoneal adhesions in rats. It is aimed to evaluate its effects on gastrointestinal wound healing.


METHODS
Thirty Wistar albino rats were divided into three groups as control, subcutan, and intraperitoneal enoxaparin groups. Left colon anastomoses were performed. On postoperative seventh day, anastomotic healing was evaluated by measuring anastomotic bursting pressure, tissue hydroxyproline levels, and histopathological examination.


RESULTS
The anastomotic bursting pressure was highest in subcutan enoxaparin group (p < 0.001), intraperitoneal enoxaparin group (p < 0.01) came the second, and the control group has the worst value. The hydroxyproline results were found nearly similar to the bursting pressure values (subcutan (p < 0.001) > intraperitoneal (p < 0.05) > control). Neovascularization in subcutan group (p < 0.001) has a statistically significant difference to other groups.


CONCLUSIONS
Enoxaparin did not interfere with colonic anastomotic resistance but improved the intestinal wound healing.
Ergul
Emre
E
General Surgery Department, Ankara Ataturk Teaching and Research Hospital, Askaabat Cad. Eser Sitesi B Blok 3.Giris, Daire:11 Bahcelievler, 06490, Ankara, Turkey. dreergul@gmail.com
Ozgun
Yigit Mehmet
YM
Kiyak
Gulten
G
Barit Ozgun
Gonca
G
Korukluoglu
Birol
B
Kusdemir
Ahmet
A
D000714:Anastomosis, Surgical; D000818:Animals; D017984:Enoxaparin / Q000494:pharmacology*; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D006909:Hydroxyproline; D007422:Intestines / Q000601:surgery; D051381:Rats; D017208:Rats, Wistar; D013529:Surgical Wound Dehiscence / Q000517:prevention & control; D000267:Tissue Adhesions / Q000517:prevention & control; D014945:Wound Healing / Q000187:drug effects*
D017984:Enoxaparin; D005343:Fibrinolytic Agents; D006909:Hydroxyproline