Nutritional status and serum zinc and selenium levels in Iranian HIV infected individuals.
BACKGROUND
Human immunodeficiency virus infected individuals are prone to malnutrition due to increased energy requirements, enteropathy and increased catabolism. Trace elements such as zinc and selenium have major role in maintaining a healthy immune system. This study was designed to evaluate the nutritional status of Iranian subjects who were newly diagnosed with human immunodeficiency virus infection and to compare serum level of zinc and selenium in these patients with those of the sex and aged match healthy subjects.


METHODS
After an interview and physical examination, nutritional assessment was done based on clinical and anthropometric parameters. Body mass index (normal range 18.5-27 kg/m2 based on age) of less than 16, 16-16.9 and 17-18.4 kg/m2 were considered as severe, moderate and mild malnutrition respectively. Serum level of zinc and selenium were measured by graphite furnace atomic absorption.


RESULTS
Severe, moderate and mild malnutrition were detected in 15%, 38% and 24% of human immunodeficiency virus infected individuals respectively. Compared with the healthy control group, serum level of zinc and selenium in the human immunodeficiency virus infected subjects were significantly lower (P = 0.01 and P = 0.02 respectively).


CONCLUSIONS
Malnutrition found to be prevalent in Iranian human immunodeficiency virus infected individuals and low serum zinc and selenium levels are common in this population.
Khalili
H
H
Department of Pharmacotherapy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. khalilih@tums.ac.ir
Soudbakhsh
A
A
Hajiabdolbaghi
M
M
Dashti-Khavidaki
S
S
Poorzare
A
A
Saeedi
A A
AA
Sharififar
R
R
D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology*; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D044342:Malnutrition / Q000150:complications / Q000453:epidemiology; D008875:Middle Aged; D009752:Nutritional Status; D012643:Selenium / Q000097:blood*; D055815:Young Adult; D015032:Zinc / Q000097:blood*
D012643:Selenium; D015032:Zinc