A severe and refractory case of anti-p200 pemphigoid resulting in multiple skin ulcers and scar formation.
Anti-p200 pemphigoid is a recently described autoimmune blistering skin disease that is characterized by the presence of autoantibodies against an unidentified 200-kDa dermal autoantigen. Most of the previous cases have been successfully treated using mild-to-moderate immunosuppressive therapies, which resulted in a good prognosis. We report here a severe and refractory case of anti-p200 pemphigoid that developed in a 53-year-old woman, in which blisters led to multiple skin ulcers, followed by severe scar formation. In the present case, methylprednisolone pulse therapy was effective enough to reduce the disease activity.
Goto-Ohguchi
Y
Y
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Nishie
W
W
Akiyama
M
M
Tateishi
Y
Y
Aoyagi
S
S
Tsuji-Abe
Y
Y
Sawamura
D
D
Ishii
N
N
Hashimoto
T
T
Shimizu
H
H
D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology; D005260:Female; D006801:Humans; D008875:Middle Aged; D024041:Non-Fibrillar Collagens / Q000276:immunology; D010391:Pemphigoid, Bullous / Q000276:immunology / Q000473:pathology*; D012867:Skin / Q000276:immunology*; D012872:Skin Diseases, Vesiculobullous / Q000276:immunology / Q000473:pathology*; D012883:Skin Ulcer / Q000209:etiology; D000097805:Collagen Type XVII
D001323:Autoantibodies; D001324:Autoantigens; D024041:Non-Fibrillar Collagens; D000097805:Collagen Type XVII