title: Drosophila viruses and the study of antiviral host-defense.
abstract: The fruit fly Drosophila melanogaster is a powerful model to study host-pathogen interactions. Most studies so far have focused on extracellular pathogens such as bacteria and fungi. More recently, viruses have come to the front, and RNA interference was shown to play a critical role in the control of viral infections in drosophila. We review here our current knowledge on drosophila viruses. A diverse set of RNA viruses belonging to several families (Rhabdoviridae, Dicistroviridae, Birnaviridae, Reoviridae, Errantiviridae) has been reported in D. melanogaster. By contrast, no DNA virus has been recovered up to now. The drosophila viruses represent powerful tools to study virus-cell interactions in vivo. Analysis of the literature however reveals that for many of them, important gaps exist in our understanding of their replication cycle, genome organization, morphology or pathogenesis. The data obtained in the past few years on antiviral defense mechanisms in drosophila, which point to evolutionary conserved pathways, highlight the potential of the D. melanogaster model to study antiviral innate immunity and to better understand the complex interaction between arthropod-borne viruses and their insect vectors.
authors.affiliation: Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France.
authors.forename: Tünde
authors.initials: T
authors.lastname: Huszar
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Imler
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster / Q000276:immunology* / Q000821:virology*; D054884:Host-Pathogen Interactions; D007113:Immunity, Innate; D007304:Insect Viruses / Q000472:pathogenicity*; D034622:RNA Interference; D012328:RNA Viruses / Q000472:pathogenicity