title: Surface-enhanced Raman scattering imaging of HER2 cancer markers overexpressed in single MCF7 cells using antibody conjugated hollow gold nanospheres.
abstract: Antibody-conjugated hollow gold nanospheres (HGNs) have been used for the SERS imaging of HER2 cancer markers overexpressed in single MCF7 cells. SERS mapping images show that HGNs have much better homogeneous scattering properties than silver nanoparticles. The results demonstrate the potential feasibility of HGNs as highly sensitive and homogeneous sensing probes for biological imaging of cancer markers in live cells.
authors.affiliation: Department of Applied Chemistry, Hanyang University, Ansan 426-791, South Korea.
authors.forename: Sangyeop
authors.initials: S
authors.lastname: Lee
authors.forename: Hyangah
authors.initials: H
authors.lastname: Chon
authors.forename: Moonkwon
authors.initials: M
authors.lastname: Lee
authors.forename: Jaebum
authors.initials: J
authors.lastname: Choo
authors.forename: Soon Young
authors.initials: SY
authors.lastname: Shin
authors.forename: Young Han
authors.initials: YH
authors.lastname: Lee
authors.forename: Im Joo
authors.initials: IJ
authors.lastname: Rhyu
authors.forename: Sang Wook
authors.initials: SW
authors.lastname: Son
authors.forename: Chil Hwan
authors.initials: CH
authors.lastname: Oh
mesh_terms: D000906:Antibodies; D014408:Biomarkers, Tumor / Q000276:immunology / Q000378:metabolism; D001943:Breast Neoplasms / Q000276:immunology / Q000378:metabolism* / Q000473:pathology*; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008853:Microscopy / Q000379:methods; D049329:Nanostructures / Q000737:chemistry / Q000648:ultrastructure; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*; D013059:Spectrum Analysis, Raman / Q000379:methods*
chemical_list: D000906:Antibodies; D014408:Biomarkers, Tumor; D003287:Contrast Media; D006046:Gold; D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human