[Oxidative stress: a review on metabolic signaling in type 1 diabetes].
Diabetic complications appear to be multifactorial process. The biochemical and pathological mechanisms are associated with chronic hyperglycemia of diabetes and the increased oxidative stress which has been postulated to play a central role in these disorders. Accumulating evidence suggests that oxidative cell injury caused by free radicals contributes to the development of type 1 diabetes (DM1) complications and decreased efficiency of antioxidant defenses (both enzymatic and nonenzymatic) seems to correlate with the severity of pathological tissue changes in DM1. In this review, we report as oxidative stress may exert deleterious effects in diabetes, as well as address current strategies in study to down-regulating vascular injury.
Reis
Janice Sepúlveda
JS
Núcleo de Pesquisa e Pós-graduação, Santa Casa de Belo Horizonte, Belo Horizonte, MG. janicesepulveda@terra.com.br
Veloso
Clara Araújo
CA
Mattos
Rafael Teixeira
RT
Purish
Saulo
S
Nogueira-Machado
José Augusto
JA
D000975:Antioxidants / Q000378:metabolism; D001669:Biochemical Phenomena; D048909:Diabetes Complications / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000150:complications; D018384:Oxidative Stress / Q000502:physiology*; D011493:Protein Kinase C / Q000502:physiology
D000975:Antioxidants; D005609:Free Radicals; D011493:Protein Kinase C