title: Human chorionic gonadotrophin producing epithelioid sarcoma metastatic to the placenta.
abstract: Pregnancy complicated by sarcoma is a rare event, and metastasis to the placenta is exceptionally rare. Of reported malignancies involving the products of conception, only 8% are sarcomas. We report the first case of placental metastasis of an epithelioid sarcoma, an uncommon malignancy which most frequently affects young adults. In addition to the typical histological features and immunophenotypic profile expected of epithelioid sarcoma, this tumor also expressed human chorionic gonadotrophin (HCG). Although uncharacteristic, the production of HCG has been previously reported in other nontrophoblastic tumors. It may have contributed to the pathogenesis of the tumor metastatic to the placenta in this case.
authors.affiliation: Department of Pathology, University of South Florida and Tampa General Hospital, Tampa, Florida 33606, USA.
authors.forename: Thora S
authors.initials: TS
authors.lastname: Steffensen
authors.forename: Enid
authors.initials: E
authors.lastname: Gilbert-Barness
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Wagoner
authors.forename: Marilyn M
authors.initials: MM
authors.lastname: Bui
authors.forename: Irwin L
authors.initials: IL
authors.lastname: Browarsky
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000378:metabolism*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D010920:Placenta / Q000473:pathology*; D010922:Placenta Diseases / Q000378:metabolism / Q000473:pathology*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000378:metabolism / Q000473:pathology*; D012509:Sarcoma / Q000378:metabolism / Q000473:pathology / Q000556:secondary*; D055815:Young Adult
chemical_list: D006063:Chorionic Gonadotropin