title: Vascular and Kupffer imaging of canine liver and spleen using the new contrast agent Sonazoid.
abstract: The new ultrasound contrast agent Sonazoid was injected in 5 healthy dogs, and the time course enhancement in liver parenchyma, portal vein, spleen, and renal cortex was evaluated. In liver parenchyma and spleen, sustained enhancement was observed from at least 8 to 15 min after injection with the peak at 45 sec (liver) and 20 sec (spleen), whereas in the portal vein and renal cortex, the time course enhancement dramatically decreased after the peak enhancement at 30 sec and 20 sec, respectively. No adverse effect was observed after Sonazoid injection in all the dogs that we examined. Contrast enhanced ultrasound using Sonazoid is believed to be useful for observing the parenchyma of canine liver and spleen.
authors.affiliation: Department of Veterinary Internal Medicine, The University of Tokyo, Tokyo, Japan. hkspark@hotmail.com
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Kanemoto
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohno
authors.forename: Ko
authors.initials: K
authors.lastname: Nakashima
authors.forename: Masashi
authors.initials: M
authors.lastname: Takahashi
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Fujino
authors.forename: Hajime
authors.initials: H
authors.lastname: Tsujimoto
mesh_terms: D000818:Animals; D003287:Contrast Media; D004285:Dogs; D005290:Ferric Compounds; D007089:Image Enhancement; D007501:Iron; D007672:Kidney Cortex / Q000000981:diagnostic imaging*; D008099:Liver / Q000000981:diagnostic imaging*; D010087:Oxides; D013154:Spleen / Q000000981:diagnostic imaging*; D014463:Ultrasonography
chemical_list: D003287:Contrast Media; D005290:Ferric Compounds; D010087:Oxides; C069727:Sonazoid; D007501:Iron