No association of single nucleotide polymorphisms in one-carbon metabolism genes with prostate cancer risk.
One-carbon metabolism mediates the interconversion of folates for the synthesis of precursors used in DNA synthesis, repair, and methylation. Inadequate folate nutrition or compromised metabolism can disrupt these processes and facilitate carcinogenesis. In this study, we investigated associations of 39 candidate single nucleotide polymorphisms (SNP) in 9 one-carbon metabolism genes with risk of prostate cancer using 1,144 cases and 1,144 controls from the Cancer Prevention Study-II Nutrition Cohort. None of these SNPs were significantly associated with prostate cancer risk, either overall or in cases with advanced prostate cancer. Thus, our findings do not support the hypothesis that common genetic variation in one-carbon metabolism genes influences prostate cancer risk.
Stevens
Victoria L
VL
Epidemiology and Surveillance Research, American Cancer Society, 250 Williams Street, Northwest, Atlanta, GA 30303-1002, USA. Victoria.Stevens@cancer.org
Rodriguez
Carmen
C
Sun
Juzhong
J
Talbot
Jeffrey T
JT
Thun
Michael J
MJ
Calle
Eugenia E
EE
D000465:Algorithms; D000483:Alleles; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D016015:Logistic Models; D008297:Male; D019875:One-Carbon Group Transferases / Q000235:genetics*; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000235:genetics*; D014481:United States / Q000453:epidemiology; D000099295:Formyltetrahydrofolate Dehydrogenase
D019875:One-Carbon Group Transferases; D000587:Oxidoreductases Acting on CH-NH Group Donors; D000099295:Formyltetrahydrofolate Dehydrogenase