Random capillary blood glucose cut points for diabetes and pre-diabetes derived from community-based opportunistic screening in India.
OBJECTIVE
To determine random capillary blood glucose (RCBG) cut points that discriminate diabetic and pre-diabetic subjects from normal individuals.


METHODS
RCBG was performed in 1,333 individuals randomly chosen from 63,305 individuals who had participated in an opportunistic screening program. An oral glucose tolerance test was also performed by venous plasma glucose on an autoanalyzer. RCBG cut points that discriminate diabetes, impaired glucose tolerance (IGT), and impaired fasting glucose (IFG) were determined using receiver operating characteristic curves.


RESULTS
Using 2-h plasma glucose >or=200 mg/dl (11.1 mmol/l) criterion, the RCBG cut point of 140 mg/dl (7.7 mmol/l) gave the highest sensitivity and specificity. For 2-h plasma glucose >or=200 mg/dl (11.1 mmol/l) and fasting plasma glucose (FPG) >or=126 mg/dl (7.0 mmol/l) criteria, either 2-h plasma glucose >or=200 mg/dl (11.1 mmol/l) or FPG >or=126 mg/dl (7.0 mmol/l) criterion, and the FPG >or=126 mg/dl (7.0 mmol/l) criterion, RCBG cut point was 143 mg/dl (7.9 mmol/l). RCBG cut points for IGT, IFG according to World Health Organization criterion, and IFG according to American Diabetes Association criterion were 119 mg/dl (6.6 mmol/l), 118 mg/dl (6.6 mmol/l), and 113 mg/dl (6.3 mmol/l), respectively.


CONCLUSIONS
Asian Indians with RCBG >110 mg/dl at screening can be recommended to undergo definitive testing.
Somannavar
Suresh
S
Madras Diabetes Research Foundation and Dr Mohan's Diabetes Specialities Centre, World Health Organization Collaborating Centre for Noncommunicable Diseases Prevention and Control, Chennai, India.
Ganesan
Anbazhagan
A
Deepa
Mohan
M
Datta
Manjula
M
Mohan
Viswanathan
V
D001786:Blood Glucose / Q000032:analysis*; D002196:Capillaries; D003920:Diabetes Mellitus / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D006801:Humans; D007194:India / Q000453:epidemiology; D008403:Mass Screening / Q000379:methods; D011236:Prediabetic State / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D012680:Sensitivity and Specificity
D001786:Blood Glucose