Organocatalytic asymmetric ring-opening of aziridines.
The organocatalytic ring-opening of N-tosyl protected aziridines by beta-ketoesters under chiral PTC-conditions, leading to the formation of optically active aminoethyl functionalised compounds with up to 99% ee, has been developed.
Paixão
Márcio W
MW
Danish National Research Foundation: Center for Catalysis, Department of Chemistry, Aarhus University, DK-8000, Aarhus C, Denmark.
Nielsen
Martin
M
Jacobsen
Christian Borch
CB
Jørgensen
Karl Anker
KA