title: Effects of perineural steroid injections on median nerve conduction during the carpal tunnel release.
abstract: OBJECTIVE
  The treatment outcome of the median nerve compressive neuropathy in the carpal zone due to carpal tunnel syndrome (CTS) is represented by recovering the nerves sensibility, conductivity, condition and strength. Perineural application of betamethasone during the surgical decompression might result in faster recovery of compressed median nerve's conduction speed.
  
  
  METHODS
  In this study 40 patients with CTS were randomly divided in the two groups. In the first group (n = 20) we performed the surgical decompression of the median nerve by the open release of the carpal tunnel, and in the second group (n = 20) we applicated a perineural injection of 1 ml of betamethason immediately after the surgical decompression. We performed the electrodiagnostic (ED) examinations 7, 30 and 90 days after the surgery, and measured the conduction speed of the median nerve in the carpal tunnel zone and the sensitivity conduction speed of the median nerve.
  
  
  RESULTS
  Significant differences in examined ED respective variable values in different time intervals were obtained. At the final measurements, 90 days after the surgical procedure, both groups evidenced a full recovery of the conduction speed in the carpal tunnel with statistically significant better results in the second group of the patients (t = -2.116; p = 0.043).
  
  
  CONCLUSIONS
  Intraoperative application of the corticosteroid injection during the surgical decompression results in faster regaining of conduction speed of the median nerve.
authors.affiliation: Military Medical Academy, Clinic for Plastic Surgery and Burns, Belgrade, Serbia. chepa@bitsyu.net
authors.forename: Nenad
authors.initials: N
authors.lastname: Stepić
authors.forename: Marjan
authors.initials: M
authors.lastname: Novaković
authors.forename: Vesna
authors.initials: V
authors.lastname: Martić
authors.forename: Dusan
authors.initials: D
authors.lastname: Perić
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001623:Betamethasone / Q000008:administration & dosage*; D002349:Carpal Tunnel Syndrome / Q000188:drug therapy / Q000601:surgery*; D003131:Combined Modality Therapy; D019299:Decompression, Surgical; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007267:Injections; D008297:Male; D008475:Median Nerve / Q000502:physiology*; D008875:Middle Aged; D009431:Neural Conduction / Q000187:drug effects*
chemical_list: D005938:Glucocorticoids; D001623:Betamethasone