title: Plasma selenium concentration and prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition (EPIC).
abstract: BACKGROUND
  Some evidence indicates that a low selenium intake may be associated with an increased risk of prostate cancer.
  
  
  OBJECTIVE
  The aim of this study was to investigate the association of plasma selenium concentration with subsequent prostate cancer risk and to examine this association by stage and grade of disease and other factors.
  
  
  METHODS
  A nested case-control study was performed among men in the European Prospective Investigation into Cancer and Nutrition (EPIC). The association between plasma selenium concentration and prostate cancer risk was assessed in 959 men with incident prostate cancer and 1059 matched controls.
  
  
  RESULTS
  Overall, plasma selenium concentration was not associated with prostate cancer risk; the multivariate relative risk for men in the highest fifth of selenium concentration compared with the lowest fifth was 0.96 (95% CI: 0.70, 1.31; P for trend = 0.25). There were no significant differences in the association of plasma selenium with risk when analyzed by stage or grade of disease. Similarly, the association of selenium with risk did not differ by smoking status or by plasma alpha- or gamma-tocopherol concentration.
  
  
  CONCLUSIONS
  Plasma selenium concentration was not associated with prostate cancer risk in this large cohort of European men.
authors.affiliation: Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom. naomi.allen@ceu.ox.ac.uk
authors.forename: Naomi E
authors.initials: NE
authors.lastname: Allen
authors.forename: Paul N
authors.initials: PN
authors.lastname: Appleby
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Roddam
authors.forename: Anne
authors.initials: A
authors.lastname: Tjønneland
authors.forename: Nina Føns
authors.initials: NF
authors.lastname: Johnsen
authors.forename: Kim
authors.initials: K
authors.lastname: Overvad
authors.forename: Heiner
authors.initials: H
authors.lastname: Boeing
authors.forename: Steffen
authors.initials: S
authors.lastname: Weikert
authors.forename: Rudolf
authors.initials: R
authors.lastname: Kaaks
authors.forename: Jakob
authors.initials: J
authors.lastname: Linseisen
authors.forename: Antonia
authors.initials: A
authors.lastname: Trichopoulou
authors.forename: Gesthimani
authors.initials: G
authors.lastname: Misirli
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Trichopoulos
authors.forename: Carlotta
authors.initials: C
authors.lastname: Sacerdote
authors.forename: Sara
authors.initials: S
authors.lastname: Grioni
authors.forename: Domenico
authors.initials: D
authors.lastname: Palli
authors.forename: Rosario
authors.initials: R
authors.lastname: Tumino
authors.forename: H Bas
authors.initials: HB
authors.lastname: Bueno-de-Mesquita
authors.forename: Lambertus A
authors.initials: LA
authors.lastname: Kiemeney
authors.forename: Aurelio
authors.initials: A
authors.lastname: Barricarte
authors.forename: Nerea
authors.initials: N
authors.lastname: Larrañaga
authors.forename: Maria-José
authors.initials: MJ
authors.lastname: Sánchez
authors.forename: Antonio
authors.initials: A
authors.lastname: Agudo
authors.forename: María-José
authors.initials: MJ
authors.lastname: Tormo
authors.forename: Laudina
authors.initials: L
authors.lastname: Rodriguez
authors.forename: Pär
authors.initials: P
authors.lastname: Stattin
authors.forename: Göran
authors.initials: G
authors.lastname: Hallmans
authors.forename: Sheila
authors.initials: S
authors.lastname: Bingham
authors.forename: Kay-Tee
authors.initials: KT
authors.lastname: Khaw
authors.forename: Nadia
authors.initials: N
authors.lastname: Slimani
authors.forename: Sabina
authors.initials: S
authors.lastname: Rinaldi
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
authors.forename: Elio
authors.initials: E
authors.lastname: Riboli
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Key
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000008:administration & dosage* / Q000378:metabolism; D016022:Case-Control Studies; D015331:Cohort Studies; D005060:Europe / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011471:Prostatic Neoplasms / Q000097:blood* / Q000453:epidemiology* / Q000473:pathology; D012307:Risk Factors; D012643:Selenium / Q000008:administration & dosage* / Q000097:blood*; D012907:Smoking / Q000009:adverse effects; D024502:alpha-Tocopherol / Q000097:blood; D024504:gamma-Tocopherol / Q000097:blood
chemical_list: D000975:Antioxidants; D024504:gamma-Tocopherol; D024502:alpha-Tocopherol; D012643:Selenium