title: Diverse regulatory mechanisms of eukaryotic transcriptional activation by the proteasome complex.
abstract: The life of any protein within a cell begins with transcriptional activation, and ends with proteolytic degradation. Intriguingly, the 26S proteasome complex, a non-lysosomal protein degradation machine comprising the 20S proteolytic core and 19S regulatory particles, has been implicated in intimate regulation of eukaryotic transcriptional activation through diverse mechanisms in a proteolysis-dependent as well as independent manner. Here, we discuss the intricate mechanisms of such proteasomal regulation of eukaryotic gene activation via multiple pathways.
authors.affiliation: Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA. sbhaumik@siumed.edu
authors.forename: Sukesh R
authors.initials: SR
authors.lastname: Bhaumik
authors.forename: Shivani
authors.initials: S
authors.lastname: Malik
mesh_terms: D000818:Animals; D005057:Eukaryotic Cells / Q000378:metabolism*; D006801:Humans; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D015533:Transcriptional Activation
chemical_list: D046988:Proteasome Endopeptidase Complex