Extract of green tea leaves partially attenuates streptozotocin-induced changes in antioxidant status and gastrointestinal functioning in rats.
Rats with severe streptozotocin (STZ)-induced diabetes were subjected to dietary green tea extract supplementation at 2 doses (0.01% and 0.2%; GTL and GTH groups, respectively) to evaluate their effects on antioxidant, gastrointestinal, and renal parameters of experimental animals. The lower dietary supplementation reflects daily consumption of 3 cups of green tea for an average adult weighing 70 kg. Supplementation of a diet with green tea extract had no influence on elevated food intake, body weight loss, increased glucose concentration, or declined antioxidant capacity of water-soluble substances in plasma in the diabetic rats. In cases of intestinal maltase activity, attenuation of liver and kidney hypertrophy, triacylglycerol concentration, and aspartate aminotransferase activity in the serum, both dietary treatments normalized metabolic disorders caused by STZ injection to a similar extent. Unlike the GTL group, the GTH treatment significantly ameliorated development of diabetes-induced abnormal values for small intestinal saccharase and lactase activities, renal microalbuminuria, thiobarbituric acid-reactive substance content in kidney tissue, as well as total antioxidant status in the serum of rats. The GTH group was also characterized by higher antioxidant capacity of lipid-soluble substances in plasma and superoxide dismutase activity in the serum. Although the higher dose of green tea extract did not completely protect against STZ-induced hyperglycemia and oxidative stress in experimental rats, this study suggests that green tea extract ingested at high amounts may prove to be a useful therapeutic option in the reversal of diabetic dysfunction.
Juśkiewicz
Jerzy
J
Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Division of Food Science, 10-747 Olsztyn, Poland. glebczo@pan.olsztyn.pl
Zduńczyk
Zenon
Z
Jurgoński
Adam
A
Brzuzan
Łucja
Ł
Godycka-Kłos
Irena
I
Zary-Sikorska
Ewa
E
D000704:Analysis of Variance; D000818:Animals; D000975:Antioxidants / Q000032:analysis; D001786:Blood Glucose / Q000032:analysis; D028241:Camellia sinensis; D002784:Cholesterol / Q000032:analysis / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism; D019587:Dietary Supplements; D041981:Gastrointestinal Tract / Q000187:drug effects; D007668:Kidney / Q000737:chemistry / Q000187:drug effects; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar; D013662:Tea; D014280:Triglycerides / Q000032:analysis / Q000097:blood
D000975:Antioxidants; D001786:Blood Glucose; D010936:Plant Extracts; D013662:Tea; D014280:Triglycerides; D002784:Cholesterol