title: Tissue engineering approaches to rotator cuff tendon deficiency.
abstract: Tissue engineering is an emerging scientific approach that may offer alternative pathways for managing tissue degeneration. The use of cellular and acellular matrix in combination with cells and/or growth factors is one approach currently being explored in the management of rotator cuff disease. Interestingly, the integration of gene therapy with this technique introduces a new dimension to treatment options. The scope of this article is to present an overview of the current tissue engineering in vivo methods being clinically investigated in rotator cuff disease.
authors.affiliation: Academic Department of Trauma and Orthopaedic Surgery, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, School of Medicine, Leeds University, Leeds, United Kingdom. etsiridis@doctors.org.uk
authors.forename: Eleftherios
authors.initials: E
authors.lastname: Tsiridis
authors.forename: Stylianos
authors.initials: S
authors.lastname: Velonis
authors.forename: David
authors.initials: D
authors.lastname: Limb
authors.forename: Peter V
authors.initials: PV
authors.lastname: Giannoudis
mesh_terms: D000818:Animals; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D017006:Rotator Cuff / Q000033:anatomy & histology / Q000473:pathology*; D012785:Shoulder Joint / Q000033:anatomy & histology / Q000473:pathology; D052256:Tendinopathy / Q000628:therapy*; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
chemical_list: D036341:Intercellular Signaling Peptides and Proteins