[Clinical effect and safety of miconazole nitrate 1200 mg in treating vulvovaginal candidiasis].
OBJECTIVE
To investigate the clinical effect and safety of miconazole nitrate 1200 mg in treating vulvovaginal candidiasis (VVC).


METHODS
An open, multicentre, non case control clinical trial was conducted in 568 patients suffering from VVC from Jul 1, 2006 to Nov 30, 2006. Routine examination, score of clinical symptoms and physical signs, mycetology test and safety evaluation were done in all patients before treatment, 7 - 14 days after treatment and 30 days after treatment.


RESULTS
Seven to fourteen days after treatment, 563 patients could be followed and 323 patients (57.3%) were cured. The overall effective rate was 90.2%. The mycologic cure rate was 91.3% (514). Thirty days after treatment, 480 patients could be followed and 411 patients (85.6%) were cured. The total effective rate was 96.0%. Mycologic cure rate was 92.3% (443/480). Adverse effect rate was 2.7% (15/563) and they were relieved without any treatment in one or two days.


CONCLUSIONS
Miconazole nitrate 1200 mg is effective in the treatment of VVC, with good compliance and few adverse effects. Moreover, it can be accepted easily.
DI
Wen
W
Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University, Shanghai 200001, China. diwen163@163.com
Duan
Tao
T
Shen
Li-Hua
LH
Zhou
Wen-Xiang
WX
Niu
Jin-Ling
JL
Luo
Xin
X
Liu
Xiao-Chun
XC
Zhang
Zhi-Fen
ZF
Rong
Feng-Hua
FH
Li
Wen-Ling
WL
D000282:Administration, Intravaginal; D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008825:Miconazole / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D008875:Middle Aged; D011537:Pruritus / Q000209:etiology; D013488:Suppositories; D016896:Treatment Outcome; D055815:Young Adult
D000935:Antifungal Agents; D013488:Suppositories; D008825:Miconazole