Cognitive and non-cognitive behaviors in an APPswe/PS1 bigenic model of Alzheimer's disease.
Neuropsychiatric signs are critical in primary caregiving of Alzheimer patients and yet have been relatively ignored in murine models. In the present study, APPswe/PS1 bigenic mice had higher levels of irritability than non-transgenic controls as measured in the touch escape test. Moreover, APPswe/PS1 mice showed poorer nest building than controls and a higher duration of immobility in the forced swimming assay. These results are concordant with the hypothesis of increased apathy and depression-like behavior in an Alzheimer's disease model. In addition, APPswe/PS1 bigenic mice were deficient in retention of passive avoidance learning and left-right discrimination learning, concordant with previous findings in other Alzheimer-like models.
Filali
M
M
Laboratory of Molecular Endocrinology, CHUL Research Center and Department of Anatomy and Physiology, Laval University, Québec, Canada. mohammad.filali@crchul.ulaval.ca
Lalonde
R
R
Rivest
S
S
D000544:Alzheimer Disease / Q000235:genetics* / Q000523:psychology*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics*; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology; D001522:Behavior, Animal / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D003863:Depression / Q000523:psychology; D004193:Discrimination Learning / Q000502:physiology; D004924:Escape Reaction / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D007508:Irritable Mood; D008297:Male; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D008822:Mice, Transgenic; D009425:Nesting Behavior; D053764:Presenilin-1 / Q000235:genetics*; D013550:Swimming / Q000523:psychology
D016564:Amyloid beta-Protein Precursor; D053764:Presenilin-1