Syntheses and evaluation of glucosyl aryl thiosemicarbazide and glucosyl thiosemicarbazone derivatives as antioxidant and anti-dyslipidemic agents.
A series of N-per-O-acetyl-glucosyl arylthiosemicarbazide and thiosemicarbazone derivatives have been synthesized and evaluated for their in vivo anti-dyslipidemic and in vitro antioxidant activities. Among 16 compounds tested, 3 compounds showed potent anti-dyslipidemic activity and 6 compounds showed potent antioxidant and scavenger of oxygen free radicals activity.
Ghosh
Samir
S
Division of Molecular Medicine, Bose Institute, P-1/12, C.I.T. Scheme VII-M, Kolkata 700054, India; Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, India.
Misra
Anup Kumar
AK
Bhatia
Gitika
G
Khan
M M
MM
Khanna
A K
AK
D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D050171:Dyslipidemias / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D012663:Semicarbazides / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use
D000975:Antioxidants; D000960:Hypolipidemic Agents; D012663:Semicarbazides; D013882:Thiosemicarbazones; C005151:thiosemicarbazide