title: [Bone mineral density and fracture risk in patients with ankylosing spondylitis].
abstract: Ankylosing spondylitis (AS) is an inflammatory disease primarily affecting the spine. Bone mineral density (BMD) is reduced in AS, particularly in male patients. Syndesmophyte formation may cause falsely increased BMD of the spine. The risk of spinal compression fractures may be 7-fold increased compared with healthy individuals. An increased risk of peripheral fractures has not been described. Structural spinal changes in advanced AS predispose to unstable vertebral fractures. Antiresorptive treatment is recommended for osteoporotic patients with AS, but the effect on BMD has never been studied in these patients.
authors.affiliation: Reumatologisk Afsnit, Medicinsk Afdeling C, Gentofte Hospital, DK-2900 Hellerup. rintek@dadlnet.dk
authors.forename: Ole Rintek
authors.initials: OR
authors.lastname: Madsen
mesh_terms: D015519:Bone Density; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D005260:Female; D005598:Fractures, Spontaneous / Q000209:etiology*; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000150:complications / Q000188:drug therapy; D012307:Risk Factors; D013117:Spinal Cord Compression / Q000209:etiology; D016103:Spinal Fractures / Q000209:etiology*; D013167:Spondylitis, Ankylosing / Q000150:complications* / Q000188:drug therapy
chemical_list: D050071:Bone Density Conservation Agents