title: A critical review of daily sedation interruption in the intensive care unit.
abstract: BACKGROUND
  Daily sedation interruption (DSI) has been proposed as a method of improving sedation management of critically ill patients by reducing the adverse effects of continuous sedation infusions.
  
  
  OBJECTIVE
  To critique the research regarding daily sedation interruption, to inform education, research and practice in this area of intensive care practice.
  
  
  METHODS
  Literature review.
  
  
  METHODS
  Medline, CINAHL and Web of Science were searched for relevant key terms. Eight research-based studies, published in the English language between 1995-December 2006 and three conference abstracts were retrieved.
  
  
  RESULTS
  Of the eight articles and three conference abstracts reviewed, five originated from one intensive care unit (ICU) in the USA. The research indicates that DSI reduces ventilation time, length of stay in ICU, complications of critical illness, incidence of post-traumatic stress disorder and is reportedly used by 15-62% of ICU clinicians in Australia, Europe, USA and Canada.
  
  
  CONCLUSIONS
  DSI improves patients' physiological and psychological outcomes when compared with routine sedation management. However, research relating to these findings has methodological limitations, such as the use of homogenous samples, single-centre trials and retrospective design, thus limiting their generalisability.
  
  
  CONCLUSIONS
  DSI may provide clinicians with a simple, cost-effective method of reducing some adverse effects of sedation on ICU patients. However, the evidence supporting DSI is limited and cannot be generalised to heterogeneous ICU populations internationally. More robust research is required to assess the potential impact of DSI on the physical and mental health of ICU survivors.
authors.affiliation: Alfred Hospital Intensive Care Unit, School of Nursing, The University of Melbourne, Carlton, Victoria, Australia. mar1oconnor2@yahoo.com.au
authors.forename: Mark
authors.initials: M
authors.lastname: O'Connor
authors.forename: Tracey
authors.initials: T
authors.lastname: Bucknall
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Manias
mesh_terms: D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D007362:Intensive Care Units
chemical_list: D006993:Hypnotics and Sedatives