[A case of familial Crohn's disease observed in a parent and his offspring].
Crohn's disease (CD), one of the major forms of idiopathic inflammatory bowel disease (IBD), is thought to be related to genetic susceptibility coupled with environmental factors. A positive family history is the strongest risk factor for the development of CD. The 10-fold increase in the familial risk of CD strongly suggests that these disorders have a genetic background. The prevalence of IBD in Asian populations is lower than in Western populations, which may be due to genetic influences, environmental factors, or a combination of both. In a Korean study, only 0.25% of parents had IBD in CD probands and all of them had ulcerative colitis. The term of familial CD was used only for those with one or more first-degree relatives with confirmed CD. There are few case reports about familial Crohn's disease in Korea. We report a case of familial CD that the father, the first degree relative was diagnosed as small bowel CD after confirming his son as having CD.
Cho
Hyun Seok
HS
Departments of Internal Medicine, Hanyang University College of Medicine, Guri, Korea.
Byun
Tae Jun
TJ
Ahn
Sang Bong
SB
Kim
Tae Yeob
TY
Eun
Chang Soo
CS
Jeon
Yong Cheol
YC
Kim
Yong Seok
YS
Han
Dong Soo
DS
D002648:Child; D003113:Colonoscopy; D003424:Crohn Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D005190:Family; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011859:Radiography