Voltage-sensing phosphatase: actions and potentials.
Voltage sensors have been well studied in voltage-gated ion channels for neuronal excitation and muscle contraction. The recent discovery of a voltage-sensing phosphatase, VSP, has changed the idea that voltage sensors are unique to ion flux through membranes. Recent findings on mechanisms and potential applications of VSP are reviewed.
Okamura
Yasushi
Y
Department of Integrative Physiology, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka, Japan. yokamura@phys2.med.osaka-u.ac.jp
Murata
Yoshimichi
Y
Iwasaki
Hirohide
H
D000818:Animals; D004789:Enzyme Activation; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology; D007473:Ion Channels / Q000737:chemistry / Q000378:metabolism; D008564:Membrane Potentials; D009474:Neurons / Q000201:enzymology / Q000502:physiology*; D051059:PTEN Phosphohydrolase / Q000737:chemistry / Q000378:metabolism; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000502:physiology*; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000378:metabolism; D017434:Protein Structure, Tertiary / Q000502:physiology
D007473:Ion Channels; D018129:Phosphatidylinositol Phosphates; C060974:phosphatidylinositol 3,4,5-triphosphate; D017853:Phosphotransferases (Alcohol Group Acceptor); C068961:phosphatidylinositol 4,5-biphosphate kinase; C509671:voltage-sensor-containing phosphatase, Ciona intestinalis; D010744:Phosphoric Monoester Hydrolases; D051059:PTEN Phosphohydrolase