title: Exogenous ochronosis.
abstract: A 55-year-old woman with melasma develops biopsy-proved exogenous ochronosis in the setting of prolonged topical hydroquinone use. A limited number of similar reports exist in the US literature and are the basis for an FDA call to review hydroquinone-based products. This case underscores the difficult therapeutic dilemma which this diagnosis presents to dermatologists.
authors.affiliation: Department of Dermatology, New York University, USA.
authors.forename: Joseph F
authors.initials: JF
authors.lastname: Merola
authors.forename: Shane
authors.initials: S
authors.lastname: Meehan
authors.forename: Ruth F
authors.initials: RF
authors.lastname: Walters
authors.forename: Lance
authors.initials: L
authors.lastname: Brown
mesh_terms: D003879:Dermatologic Agents / Q000009:adverse effects*; D003937:Diagnosis, Differential; D005148:Facial Dermatoses / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D005260:Female; D006801:Humans; D006873:Hydroquinones / Q000009:adverse effects*; D008548:Melanosis / Q000188:drug therapy*; D008875:Middle Aged; D009794:Ochronosis / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology
chemical_list: D003879:Dermatologic Agents; D006873:Hydroquinones; C031927:hydroquinone