Stem cells for the treatment of skeletal muscle injury.
Skeletal muscle injuries are extremely common, accounting for up to 35%-55% of all sports injuries and quite possibly affecting all musculoskeletal traumas. These injuries result in the formation of fibrosis, which may lead to the development of painful contractures, increases patients' risk for repeat injuries, and limits their ability to return to a baseline or pre-injury level of function. The development of successful therapies for these injuries must consider the pathophysiology of these musculoskeletal conditions. We discuss the direct use of muscle-derived stem cells and some key cell population dynamics as well as the use of clinically applicable modalities that may enhance the local supply of stem cells to the zone of injury by promoting angiogenesis.
Quintero
Andres J
AJ
Stem Cell Research Center, Children's Hospital of Pittsburgh, 4100 Rangos Research Center, 3640 Fifth Avenue, Pittsburgh, PA 15213-2582, USA.
Wright
Vonda J
VJ
Fu
Freddie H
FH
Huard
Johnny
J
D001265:Athletic Injuries / Q000601:surgery; D005355:Fibrosis / Q000503:physiopathology; D006801:Humans; D007249:Inflammation; D018482:Muscle, Skeletal / Q000293:injuries*; D009135:Muscular Diseases / Q000601:surgery*; D012307:Risk Factors; D017695:Soft Tissue Injuries / Q000601:surgery*; D033581:Stem Cell Transplantation; D023822:Tissue Engineering