Apolipoprotein E gene polymorphism and polycystic ovary syndrome patients in Western Anatolia, Turkey.
OBJECTIVE
Dyslipidemia, cardiovascular disease and hypertension are more frequently seen in patients with PCOS than in normal patients. We aimed at evaluating the distribution of Apo E alleles that can influence cardiovascular risk of the PCOS patients and control subjects.


METHODS
In this study, 129 young women with PCOS and 91 healthy women were included. In all subjects we performed hormonal, biochemical and Apo E genetic analysis.


RESULTS
The Apo E3 allele was found at a significantly higher frequency in the PCOS patient group compared with the control group. The Apo E2 allele was found at a significantly higher frequency in the control group compared with the patient group with PCOS.


CONCLUSIONS
Although there were genotype and allele differences between control and patient groups in this study, no statistically significant change was determined in lipid and other cardiovascular risk factors in connection with allele and genotype.
Cetinkalp
Sevki
S
Department of Endocrinology and Metabolism Disease, Division of Internal Medicine, Ege University Hospital, Izmir, Turkey.
Karadeniz
Muammer
M
Erdogan
Mehmet
M
Zengi
Ayhan
A
Cetintas
Vildan
V
Tetik
Asli
A
Eroglu
Zuhal
Z
Kosova
Buket
B
Ozgen
A Gokhan
AG
Saygili
Fusun
F
Yilmaz
Candeger
C
D000328:Adult; D001057:Apolipoproteins E / Q000235:genetics*; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D011388:Prolactin / Q000097:blood; D012307:Risk Factors; D017422:Sequence Analysis, DNA; D014421:Turkey / Q000453:epidemiology
D001057:Apolipoproteins E; D011388:Prolactin; D007986:Luteinizing Hormone