title: The effect of gas-phase reactions on the quantitation of cyclic hydrazone libraries by electrospray ionization (ESI) mass spectrometry.
abstract: Using mass spectrometry coupled with LC analysis we report evidence of diastereomer dependent fragmentation and oligomerization reactions in the ionization of acyl-hydrazone-based libraries of cyclic oligomers. These effects can significantly affect the accuracy of MS-based quantitations, but also provide a venue for examining ionization effects in dynamic combinatorial libraries (DCLs).
authors.affiliation: Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, USA.
authors.forename: Holly
authors.initials: H
authors.lastname: Schiltz
authors.forename: Mee-Kyung
authors.initials: MK
authors.lastname: Chung
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Lee
authors.forename: Michel R
authors.initials: MR
authors.lastname: Gagné