Evaluation of a new method of assessing depth of sedation using two-choice visual reaction time testing on a mobile phone.
The utility of two-choice visual reaction time testing using a specially programmed mobile telephone as a measure of sedation level was investigated in 20 healthy patients sedated with target controlled infusions of propofol. At gradually increasing target concentrations visual reaction time was compared with patient-assessed visual analogue scale sedation scores and an observer-rated scale. Propofol sedation caused dose-dependent increases in visual reaction time and visual analogue scale scores that were statistically significant when the calculated effect-site concentration reached 0.9 microg.ml(-1) (p < 0.05) and 0.5 microg.ml(-1) (p < 0.01) respectively. While visual analogue scale scores were more sensitive at lower levels of sedation than visual reaction time, the latter demonstrated marked increase in values at higher levels of sedation. Visual reaction time may be useful for identifying impending over-sedation.
Thomson
A J
AJ
Department of Anaesthesia, Critical Care and Pain Medicine, Ral Infirmary of Edinburgh, Edinburgh, UK.
Nimmo
A F
AF
Tiplady
B
B
Glen
J B
JB
D000328:Adult; D040421:Cell Phone; D002755:Choice Behavior / Q000187:drug effects; D016292:Procedural Sedation / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005556:Form Perception / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D010775:Photic Stimulation / Q000379:methods; D015742:Propofol / Q000008:administration & dosage / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects*
D006993:Hypnotics and Sedatives; D015742:Propofol