GATA-3 as a marker of hormone response in breast cancer.
GATA-3 is a transcription factor that orchestrates gene expression profiles during embryogenesis of a variety of human tissues, including hematopoietic cells, skin, kidney, mammary gland, and the central nervous system. Among several other roles, GATA-3 has recently been identified as a key player of luminal cell differentiation in the mammary gland. The majority of breast cancers arise from luminal epithelial cells and hence GATA-3 appears to control a set of genes involved in the differentiation and proliferation of breast cancer. The expression of GATA-3 has a strong association with the expression of estrogen receptor-alpha (ER) in breast cancer, and there is mounting evidence that GATA-3 can be used as a clinical marker to determine response to hormonal therapy and to refine the prognosis of breast cancer patients. Here, we review the literature from the past 10 y on GATA-3 in normal and pathological states of the mammary gland. Conclusions from the literature are confirmed using meta-analyses performed by the Oncomine Research Platform.
Fang
Sandy H
SH
Department of Surgery, University of Iowa, Iowa City, Iowa 52242, USA.
Chen
Yizhen
Y
Weigel
Ronald J
RJ
D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D002454:Cell Differentiation; D049109:Cell Proliferation; D005260:Female; D050990:GATA3 Transcription Factor / Q000378:metabolism*; D006801:Humans; D016896:Treatment Outcome
D018931:Antineoplastic Agents, Hormonal; D014408:Biomarkers, Tumor; D050990:GATA3 Transcription Factor; C494749:GATA3 protein, human