Photoinduced nitric oxide and singlet oxygen release from ZnPC liposome vehicle associated with the nitrosyl ruthenium complex: synergistic effects in photodynamic therapy application.
Under continuous photolysis at 675 nm, liposomal zinc phthalocyanine associated with nitrosyl ruthenium complex [Ru(NH.NHq)(tpy)NO](3+) showed the detection and quantification of nitric oxide (NO) and singlet oxygen ((1)O(2)) release. Photophysical and photochemical results demonstrated that the interaction between the nitrosyl ruthenium complex and the photosensitizer can enable an electron transfer process from the photosensitizer to the nitrosyl ruthenium complex which leads to NO release. Synergistic action of both photosensitizers and the nitrosyl ruthenium complex results in the production of reactive oxygen species and reactive nitrogen species, which is a potent oxidizing agent to many biological tissues, in particular neoplastic cells.
Maranho
Daniela Silva
DS
Departamento de Química, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto SP, Brazil.
de Lima
Renata Galvão
RG
Primo
Fernando Lucas
FL
da Silva
Roberto Santana
RS
Tedesco
Antonio Claudio
AC
D004563:Electrochemistry; D005453:Fluorescence; D008081:Liposomes; D009569:Nitric Oxide / Q000737:chemistry*; D010777:Photochemistry; D010778:Photochemotherapy; D017975:Ruthenium Compounds / Q000737:chemistry*; D026082:Singlet Oxygen / Q000737:chemistry*
D008081:Liposomes; D017975:Ruthenium Compounds; D026082:Singlet Oxygen; D009569:Nitric Oxide