[Effect of vasoactive drugs on visual functions and ocular hemodynamics in patients with primary open-angle glaucoma].
The effect of cavinton forte on visual functions and ocular hemodynamics was studied in patients with primary open-angle glaucoma (POAG). Fifty-three patients (97 eyes) aged 45 to 75 years (mean age 66.3 +/- 3.7 years) who had POAG were examined. A study group comprised 38 patients (67 eyes, including 24 with Stage Ia POAG, 27 with Stage IIa, 16 with Stage IIIa). All these patients took cavinton forte (10 mg) thrice daily for 2 months. A control group consisted of 15 patients (30 eyes) receiving no vasoactive agents. In these patients, intraocular pressure was normalized and it was in the range of 15 to 21 mm Hg after Goldmann. The use of the vasoactive drug cavinton forte improved and stabilized visual functions in POAG patients with normalized intraocular pressure, which is particularly important with advanced POAG. Increased blood flow velocity in the ocular arteries after a course of therapy with cavinton forte suggests a better retinal blood supply, which is a favorable marker for the prediction of the disease.
Makashova
N V
NV
Kiseleva
T N
TN
Ronzina
I A
IA
Vasil'eva
A E
AE
D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001783:Blood Flow Velocity; D005902:Glaucoma, Open-Angle / Q000145:classification / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008875:Middle Aged; D012171:Retinal Vessels / Q000187:drug effects*; D013997:Time Factors; D016896:Treatment Outcome; D018608:Ultrasonography, Doppler; D014748:Vinca Alkaloids / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D014785:Vision, Ocular / Q000187:drug effects*
D000959:Antihypertensive Agents; D014748:Vinca Alkaloids; C013983:vinpocetine