Obesity and diabetes: lipids, 'nowhere to run to'.
Although specific pathogenic entities contributing to diabetic risk, such as central adiposity, ectopic fat accumulation, hyperlipidaemia and inflammation, are well-characterized, the response of cellular systems to such insults are less well understood. This short review highlights the effect of increasing fat mass on ectopic fat accumulation, the role of triacylglycerols (triglycerides) in Type 2 diabetes mellitus and cardiovascular disease pathogenesis, and selected current therapeutic strategies used to ameliorate these risk factors.
Hill
Margaret J
MJ
Clinical Sciences Research Institute, Warwick Medical School, University Hospitals Coventry and Warwickshire, Coventry CV2 2DX, UK. margaret.hill@warwick.ac.uk
Metcalfe
David
D
McTernan
Philip G
PG
D017667:Adipocytes / Q000473:pathology; D050154:Adiposity / Q000502:physiology; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism; D032383:Myocytes, Cardiac / Q000378:metabolism; D009765:Obesity / Q000150:complications* / Q000378:metabolism; D045162:Thiazolidinediones / Q000627:therapeutic use
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D045162:Thiazolidinediones