title: Host factors do not influence the colonization or infection by fluconazole resistant Candida species in hospitalized patients.
abstract: Nosocomial yeast infections have significantly increased during the past two decades in industrialized countries, including Taiwan. This has been associated with the emergence of resistance to fluconazole and other antifungal drugs. The medical records of 88 patients, colonized or infected with Candida species, from nine of the 22 hospitals that provided clinical isolates to the Taiwan Surveillance of Antimicrobial Resistance of Yeasts (TSARY) program in 1999 were reviewed. A total of 35 patients contributed fluconazole resistant strains [minimum inhibitory concentrations (MICs) > or = 64 mg/l], while the remaining 53 patients contributed susceptible ones (MICs < or = 8 mg/l). Fluconazole resistance was more frequent among isolates of Candida tropicalis (46.5%) than either C. albicans (36.8%) or C. glabrata (30.8%). There was no significant difference in demographic characteristics or underlying diseases among patients contributing strains different in drug susceptibility.
authors.affiliation: Division of Clinical Research, National Health Research Institutes, Miaoli, Taiwan, Republic of China. yyang@mail.nctu.edu.tw
authors.forename: Yun-Liang
authors.initials: YL
authors.lastname: Yang
authors.forename: Ming-Fang
authors.initials: MF
authors.lastname: Cheng
authors.forename: Ya-Wen
authors.initials: YW
authors.lastname: Chang
authors.forename: Tzuu-Guang
authors.initials: TG
authors.lastname: Young
authors.forename: Hsin
authors.initials: H
authors.lastname: Chi
authors.forename: Sai Cheong
authors.initials: SC
authors.lastname: Lee
authors.forename: Bruno Man-Hon
authors.initials: BM
authors.lastname: Cheung
authors.forename: Fan-Chen
authors.initials: FC
authors.lastname: Tseng
authors.forename: Tun-Chieh
authors.initials: TC
authors.lastname: Chen
authors.forename: Yu-Huai
authors.initials: YH
authors.lastname: Ho
authors.forename: Zhi-Yuan
authors.initials: ZY
authors.lastname: Shi
authors.forename: Chung-Huang Hubert
authors.initials: CH
authors.lastname: Chan
authors.forename: Ju-Yu
authors.initials: JY
authors.lastname: Lin
authors.forename: Hsiu-Jung
authors.initials: HJ
authors.lastname: Lo
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002175:Candida / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification*; D002177:Candidiasis / Q000188:drug therapy / Q000382:microbiology*; D025141:Drug Resistance, Fungal; D015725:Fluconazole / Q000494:pharmacology* / Q000627:therapeutic use; D006760:Hospitalization; D006801:Humans; D013624:Taiwan / Q000453:epidemiology
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole