Innate immune recognition of the indigenous microbial flora.
Our studies have focused on understanding the mechanisms of interactions between the indigenous intestinal flora and the mammalian host in both physiological and nonphysiological conditions. In particular, we have focused on the function of innate microbial pattern recognition by Toll-like receptors in the context of tissue injury and repair, spontaneous colitis, and postnatal development.
Rakoff-Nahoum
S
S
Department of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA. seth.rakoff-nahoum@yale.edu
Medzhitov
R
R
D000375:Aging / Q000276:immunology; D000818:Animals; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D015212:Inflammatory Bowel Diseases / Q000276:immunology / Q000473:pathology; D016753:Interleukin-10 / Q000276:immunology / Q000378:metabolism; D007422:Intestines / Q000254:growth & development / Q000276:immunology* / Q000382:microbiology*; D051193:Toll-Like Receptors / Q000276:immunology / Q000378:metabolism
D051193:Toll-Like Receptors; D016753:Interleukin-10