title: Graphical representation of proteins as four-color maps and their numerical characterization.
abstract: We put forward a novel compact 2-D graphical representation of proteins based on the concept of virtual genetic code and a four-color map. The novel graphical representation uniquely represents proteins and allows one to easily and quickly visually observe and inspect similarity/dissimilarity between them. It also leads to a novel protein descriptor, a 10-dimensional vector derived from a novel structure matrix S associated with the map. The introduced numerical characterization of proteins is not only useful for their comparative study, but also for cataloguing information on a single protein. The approach is illustrated with the A chain of human insulin and the A chain of human insulin analogue glargine.
authors.affiliation: National Institute of Chemistry, 1001 Ljubljana, Slovenia. mrandic@msn.com
authors.forename: Milan
authors.initials: M
authors.lastname: Randić
authors.forename: Ketij
authors.initials: K
authors.lastname: Mehulić
authors.forename: Damir
authors.initials: D
authors.lastname: Vukicević
authors.forename: Tomaz
authors.initials: T
authors.lastname: Pisanski
authors.forename: Drazen
authors.initials: D
authors.lastname: Vikić-Topić
authors.forename: Dejan
authors.initials: D
authors.lastname: Plavsić
mesh_terms: D003196:Computer Graphics; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry; D007328:Insulin / Q000031:analogs & derivatives / Q000737:chemistry / Q000235:genetics; D000069036:Insulin Glargine; D049528:Insulin, Long-Acting; D011506:Proteins / Q000737:chemistry* / Q000235:genetics; D020539:Sequence Analysis, Protein / Q000379:methods*
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin; D049528:Insulin, Long-Acting; D011506:Proteins; D000069036:Insulin Glargine