Quantitative characterization of degradation behaviors of antioxidants stabilized in lipid particles.
This study describes a flexible approach that allows us to characterize the long-term stability of antioxidants by using a thermodynamically extended Arrhenius equation. We use retinol, Vitamin A, as a model antioxidant and its degradation behaviors are characterized for both stabilized and non-stabilized systems; in this study, by using a fluid bed technique, we immobilize the retinol in lipid particles, thus increasing its thermal stability in complex formulations, such as aqueous polymer gels and emulsions. Our approach demonstrates that the degradation behaviors of the retinol show a functional relationship with temperature and time, which makes it possible to use the Arrhenius approach. This result allows us to precisely characterize the stability of antioxidants in complex formulations for long time.
Han
Sang-Hoon
SH
Amore-Pacific Co. R&D Center, 314-1, Bora-dong, Giheung-gu, Yongin-si, Gyeonggi-do 449-729, South Korea.
Lee
Jong-Suk
JS
Kim
Yong-Jin
YJ
Kim
Junoh
J
Chang
Ih-Seop
IS
Chung
Dong June
DJ
Suh
Kyung-Do
KD
Kim
Jin-Woong
JW