Modified citrus pectin anti-metastatic properties: one bullet, multiple targets.
In this minireview, we examine the ability of modified citrus pectin (MCP), a complex water soluble indigestible polysaccharide obtained from the peel and pulp of citrus fruits and modified by means of high pH and temperature treatment, to affect numerous rate-limiting steps in cancer metastasis. The anti-adhesive properties of MCP as well as its potential for increasing apoptotic responses of tumor cells to chemotherapy by inhibiting galectin-3 anti-apoptotic function are discussed in the light of a potential use of this carbohydrate-based substance in the treatment of multiple human malignancies.
Glinsky
Vladislav V
VV
Harry S. Truman Memorial Veterans' Hospital, Columbia, MO 65201, USA.
Raz
Avraham
A
D000818:Animals; D023102:Anoikis / Q000187:drug effects; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D002957:Citrus / Q000737:chemistry; D037502:Galectin 3 / Q000037:antagonists & inhibitors; D006801:Humans; D009361:Neoplasm Invasiveness / Q000503:physiopathology; D009362:Neoplasm Metastasis / Q000188:drug therapy*; D009389:Neovascularization, Pathologic / Q000188:drug therapy; D010368:Pectins / Q000737:chemistry / Q000627:therapeutic use*; D010936:Plant Extracts
D000972:Antineoplastic Agents, Phytogenic; D037502:Galectin 3; D010936:Plant Extracts; D010368:Pectins