Highly diastereoselective Zn/SnCl2-mediated gem-difluoroallylation of chiral hydrazones.
gem-Difuoroallylic zinc reacts with chiral hydrazones 1 in the presence of SnCl(2) to afford the versatile and chiral fluorinated building blocks, gem-difluorohomoallylic amines, in good yields and high diastereoselectivities.
Yue
Xuyi
X
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China.
Zhang
Xingang
X
Qing
Feng-Ling
FL
D000478:Alkylation; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D006835:Hydrazones / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D017971:Tin Compounds / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
D000588:Amines; D006835:Hydrazones; D017971:Tin Compounds; C023599:stannous chloride; D015032:Zinc