Functional MRI: evaluation of chronic kidney disease with perfusion imaging.
OBJECTIVE
To evaluate the functional alterations of chronic kidney disease (CKD) with magnetic resonance dynamic perfusion imaging.


METHODS
Twenty-one healthy subjects (42 kidneys) and 20 CKD patients (40 kidneys) underwent routine scans with fat-saturated T1-weighted fast low angle shot (FLASH) and true-fast imaging with steady-state precession (FISP) sequences followed by dynamic perfusion scans using a turbo-FLASH T1-weighted sequence. Signal intensity (SI) of the cortex and medulla on images was measured and plotted as a function of time. Peak height (P) and time to peak (T) of the cortex and medulla SI were estimated, and P/T ratio and the area under the time-intensity curves were calculated. We also tested the correlation between these data and serum creatinine (sCr) levels in patients.


RESULTS
P, P/T ratio, and the area under the curve of patients' cortex and medulla were significantly decreased compared to control subjects, and T was delayed. In patients, P and P/T ratio of the cortex and P of the medulla were negatively correlated with sCr levels (r = -0.469, r = -0.419, and r = -0.423, respectively; P < 0.01).


CONCLUSIONS
Renal dysfunction in CKD can be evaluated by magnetic resonance dynamic perfusion imaging.
Pei
Xin-Long
XL
Department of Radiology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, 100083, China.
Xie
Jing-Xia
JX
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007676:Kidney Failure, Chronic / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult
D019786:Gadolinium DTPA