[Hypothyroidism associated to menopause symptoms worsening change with thyroid substitution therapy].
BACKGROUND
Hypothyroidism is more frequent in woman and raises with age. It is not clear why do they have greater susceptibility, but it seems to be related with levels of estrogens and hormonal changes.


OBJECTIVE
To evaluate changes in symptoms of women with menopause and hypothyroidism after receiving hypothyroidism therapy and later hormonal therapy.


METHODS
Longitudinal, descriptive and comparative study. Two groups were formed: one with 27 patients with hypothyroidism diagnoses and menopause, and the other with 27 menopausal patients matched by age. Appraisal criterion of hormonal therapy efficacy was Greene scale. Levotiroxine was employed as hypothyroidism therapy, at doses required to get euthyroidism in each patient.


RESULTS
Basal climacteric symptoms' intensity was higher in patients with menopause and hypothyroidism, which decrease significantly (p < 0.05) after hypothyroidism therapy.


CONCLUSIONS
Climacteric symptoms are more intense in patients with hypothyroidism, but they fall when euthyroidism is maintained. These changes in thyroid function can be associated to changes in estrogens concentrations, and therefore in direct relation to TRH neurohormone (thyroid releasing hormones).
Hernández Valencia
Marcelino
M
Hospital de Especialidades, Centro Médico Nacional Siglo XXI, IMSS. mhernandezvalencia@prodigy.net.mx
Córdova Pérez
Nydia
N
Zárate
Arturo
A
Basurto
Lourdes
L
Manuel Apolinar
Leticia
L
Ruiz
Miriam
M
Vargas
Carlos
C
Vargas
Antonio
A
D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D007037:Hypothyroidism / Q000188:drug therapy*; D008137:Longitudinal Studies; D008593:Menopause; D008875:Middle Aged; D012720:Severity of Illness Index; D013974:Thyroxine / Q000627:therapeutic use*
D013974:Thyroxine