title: Long-term intensive insulin therapy for Japanese patients with type 2 diabetes mellitus.
abstract: OBJECTIVE
  To determine the clinical usefulness of long-term intensive insulin therapy in Japanese patients with type 2 diabetes.
  
  
  METHODS
  Various clinical indicators and potential of withdrawal from insulin therapy were investigated in 20 type 2 diabetic patients receiving treatment in the outpatient clinic over a period of 8 years after starting intensive insulin therapy between April 1997 and March 1999.
  
  
  RESULTS
  The mean glycated hemoglobin (HbA1c) was approximately 6.5%, and there was no significant increase in insulin dose over a period of 8 years after commencement of intensive insulin therapy. Withdrawal from insulin therapy could be sustained in previously untreated patients.
  
  
  CONCLUSIONS
  Our results indicated the clinical usefulness of intensive insulin therapy over the long term in Japanese patients with type 2 diabetes and that such therapy could be especially useful for previously untreated patients.
authors.affiliation: Internal Medicine, Division of Nephrology and Metabolism, Tokai University School of Medicine, Isehara. umechan@is.icc.u-tokai.ac.jp
authors.forename: Tomoya
authors.initials: T
authors.lastname: Umezono
authors.forename: Masao
authors.initials: M
authors.lastname: Toyoda
authors.forename: Makiko
authors.initials: M
authors.lastname: Abe
authors.forename: Keiko
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Mayuko
authors.initials: M
authors.lastname: Kato
authors.forename: Masaaki
authors.initials: M
authors.lastname: Miyauchi
authors.forename: Takako
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Yamamoto
authors.forename: Moritsugu
authors.initials: M
authors.lastname: Kimura
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Yagame
authors.forename: Daisuke
authors.initials: D
authors.lastname: Suzuki
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007328:Insulin / Q000008:administration & dosage* / Q000097:blood; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D007328:Insulin