title: Characterization and phylogenetic relationships of strains of Dengue type 1 virus from Costa Rica.
abstract: Phylogenetic analysis of the envelope gene sequence (E) of three isolated Dengue virus type 1 (DEN-1) sequences from the Costa Rican 1993 epidemic was performed. All the strains fell into genotype V. Genotype V has grouped all the strains isolated from America, three strains from Africa and two strains from Asia. Costa Rican strains are closely related to the strain from Angola and to the Brazil 1990 strain. Costa Rican strains are able to cause DHF but with low clinical disease severity and low incidence maybe because of low virulence.
authors.affiliation: Caja Costarricense del Seguro Social, Hospital San Juan de Dios, Departamento de Análisis Clinico y Microbiología, San José, Costa Rica. cesar.virologia.ucr@costarricense.cr
authors.forename: César-Alonso
authors.initials: CA
authors.lastname: Cerdas-Quesada
authors.forename: Axel P
authors.initials: AP
authors.lastname: Retana-Salazar
mesh_terms: D003364:Costa Rica / Q000453:epidemiology; D003715:Dengue / Q000453:epidemiology / Q000821:virology*; D003716:Dengue Virus / Q000145:classification / Q000235:genetics*; D004196:Disease Outbreaks; D005814:Genes, Viral / Q000235:genetics; D005838:Genotype; D006801:Humans; D010802:Phylogeny; D014759:Viral Envelope Proteins / Q000235:genetics*
chemical_list: D014759:Viral Envelope Proteins