title: Metallothionein and metal levels in liver, gills and kidney of Sparus aurata exposed to sublethal doses of cadmium and copper.
abstract: The levels of metallothionein (MT), a biomarker of metal exposure, and of Cd and Cu, known as MT inducers, were investigated in Sparus aurata intraperitoneally injected with 500 microg/kg of Cu and Cd for 2 days. MT and metal concentrations (Cd and Cu) were determined in liver, gills and kidney. MT levels were significantly increased in all investigated tissues, with the highest value in liver of Cu as Cd-treated fishes (3.56-fold and 3.3- fold, respectively). Metal concentrations were statistically different between all tissues. Highest metal concentrations were in the liver. The higher metal concentrations and MT induction levels support the main role of MT in metal homeostasis and detoxification.
authors.affiliation: Laboratoire de Biochimie et de Toxicologie Environnementale, Institut Supérieur d'Agronomie de Chott-Mariem, 4042 Sousse, Tunisia.
authors.forename: J
authors.initials: J
authors.lastname: Ghedira
authors.forename: J
authors.initials: J
authors.lastname: Jebali
authors.forename: Z
authors.initials: Z
authors.lastname: Bouraoui
authors.forename: M
authors.initials: M
authors.lastname: Banni
authors.forename: H
authors.initials: H
authors.lastname: Guerbej
authors.forename: H
authors.initials: H
authors.lastname: Boussetta
mesh_terms: D000825:Animal Structures / Q000737:chemistry*; D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D003300:Copper / Q000633:toxicity*; D005786:Gene Expression Regulation / Q000187:drug effects; D005880:Gills / Q000737:chemistry; D007668:Kidney / Q000737:chemistry; D008099:Liver / Q000737:chemistry; D008668:Metallothionein / Q000378:metabolism*; D008670:Metals / Q000378:metabolism*; D021541:Sea Bream; D014874:Water Pollutants, Chemical / Q000633:toxicity
chemical_list: D008670:Metals; D014874:Water Pollutants, Chemical; D002104:Cadmium; D003300:Copper; D008668:Metallothionein