title: Efficient cleavage of Bid and procaspase-7 by caspase-2 at lower pH.
abstract: The activity of caspase-2 was examined under varying biochemical conditions with the synthetic and protein substrates, Bid and procaspase-7. The results indicate that it was largely influenced by pH which might be one reason behind the inconsistency for the cleavage of its established substrates during caspase-2-induced apoptosis.
authors.affiliation: Research Center for Proteineous Materials (RCPM), Department of Bio-Materials Engineering, School of Medicine, College of Natural Sciences, Chosun University, Gwangju, 501-759, Republic of Korea.
authors.forename: Pratap
authors.initials: P
authors.lastname: Karki
authors.forename: Giri Raj
authors.initials: GR
authors.lastname: Dahal
authors.forename: Song Yub
authors.initials: SY
authors.lastname: Shin
authors.forename: Jung Sup
authors.initials: JS
authors.lastname: Lee
authors.forename: Byungyun
authors.initials: B
authors.lastname: Cho
authors.forename: Il-Seon
authors.initials: IS
authors.lastname: Park
mesh_terms: D000818:Animals; D051023:BH3 Interacting Domain Death Agonist Protein / Q000378:metabolism*; D053143:Caspase 2 / Q000378:metabolism*; D053179:Caspase 7 / Q000378:metabolism*; D053181:Caspase 8 / Q000378:metabolism; D061945:Caspase Inhibitors; D002417:Cattle; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000235:genetics; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D011485:Protein Binding / Q000187:drug effects; D011499:Protein Processing, Post-Translational; D012965:Sodium Chloride / Q000494:pharmacology
chemical_list: D051023:BH3 Interacting Domain Death Agonist Protein; D061945:Caspase Inhibitors; D012965:Sodium Chloride; D053143:Caspase 2; D053179:Caspase 7; D053181:Caspase 8