[Protective effects of nanometer selenium on acute gastric mucosal lesion in rats].
OBJECTIVE
To study the protective effects of nanometer selenium on acute gastric mucosal lesion in rats.


METHODS
50 healthy Wister rats were divided into five groups randomly: normal group, model group, and three experimental groups (4.17, 8.33 and 16.67 mg/kg). The lesion of gastric mucosal was established by giving absolute alcohol after giving nanometer selenium of different dosage to rats except normal group, examined histopathology of gastric mucosa, then measured the lesion index (UI)of rats in normal group, model group and three experimental groups. The activity of glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) content in blood were determined.


RESULTS
Gastric mucosal lesion index of all the three experimental groups was obviously reduced compared with the control groups (P < 0.01) and existed dose dependent. The nanometer selenium elevated GSH-Px activity (P < 0.01) but reduced MDA content (P < 0.05, P < 0.01). In addition, the extent of mucosal lesion of experimental groups was significantly less than that of experimental control.


CONCLUSIONS
Nanometer selenium can significantly prevent absolute ethanol-induced acute gastric mucosal lesion. The mechanism may be related to the antioxidation of the powder.
Yu
Xiaohong
X
Department of Nutrition and Food Hygiene, Baotou Medical College, Baotou 014010, China. yuxiaohong224@163.com
Xu
Xiuju
X
Su
Jun
J
D000818:Animals; D000431:Ethanol / Q000009:adverse effects; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D008297:Male; D053768:Metal Nanoparticles / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000627:therapeutic use*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*
D000431:Ethanol; D012643:Selenium