title: Nitroxyl radicals as low toxic spin-labels for non-invasive magnetic resonance imaging of blood-brain barrier permeability for conventional therapeutics.
abstract: The present study describes a novel non-radioactive methodology for in vivo non-invasive, real-time imaging of blood-brain barrier (BBB) permeability for conventional drugs, using nitroxyl radicals as spin-labels and magnetic resonance imaging (MRI).
authors.affiliation: Department of Biophysics, Molecular Imaging Center, National Institute of Radiological Sciences, Inage-ku, Chiba 263-8555, Japan.
authors.forename: Zhivko
authors.initials: Z
authors.lastname: Zhelev
authors.forename: Rumiana
authors.initials: R
authors.lastname: Bakalova
authors.forename: Ichio
authors.initials: I
authors.lastname: Aoki
authors.forename: Ken-Ichiro
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Veselina
authors.initials: V
authors.lastname: Gadjeva
authors.forename: Kazunori
authors.initials: K
authors.lastname: Anzai
authors.forename: Iwao
authors.initials: I
authors.lastname: Kanno
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents; D000975:Antioxidants; D001345:Autoradiography; D001812:Blood-Brain Barrier / Q000033:anatomy & histology* / Q000187:drug effects*; D003497:Cyclic N-Oxides; D004353:Drug Evaluation, Preclinical; D005609:Free Radicals / Q000737:chemistry*; D007202:Indicators and Reagents; D008130:Lomustine / Q000031:analogs & derivatives; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D017672:Nitrogen Compounds / Q000737:chemistry* / Q000633:toxicity; D009589:Nitrogen Oxides / Q000737:chemistry*; D010539:Permeability / Q000187:drug effects; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D049268:Positron-Emission Tomography; D013113:Spin Labels / Q000138:chemical synthesis*
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D003497:Cyclic N-Oxides; D005609:Free Radicals; D007202:Indicators and Reagents; D017672:Nitrogen Compounds; D009589:Nitrogen Oxides; D004364:Pharmaceutical Preparations; D013113:Spin Labels; D008130:Lomustine; C039900:nitroxyl; C003959:TEMPO