title: Niuchangchih (Antrodia camphorata) and its potential in treating liver diseases.
abstract: Niuchangchih (Antrodia camphorata (M. Zang & C.H. Su) Sheng H. Wu, Ryvarden & T.T. Chang) is a basidiomycete endemic to Taiwan. It is well known as a Traditional Chinese Medicine (TCM), and Taiwanese aborigines used this species to treat liver diseases and food and drug intoxication. The compounds identified in Niuchangchih are predominantly polysaccharides, triterpenoids, steroids, benzenoids and maleic/succinic acid derivatives. Recent research has revealed that Niuchangchih possesses extensive biological activity, such as hepatoprotective, antihypertensive, anti-hyperlipidemic, immuno-modulatory, anticancer, anti-inflammatory and antioxidant activities. The fruiting bodies and fermented products of Niuchangchih have been reported to exhibit activity when treating liver diseases, such as preventing ethanol-, CCl(4)- and cytokine-induced liver injury, inhibiting the hepatitis B virus, ameliorating fatty liver and liver fibrosis, and inhibiting liver cancer cells. This review will address the protective effects of Niuchangchih on the pathological development of liver diseases, and the underlying mechanisms of action are also discussed.
authors.affiliation: Laboratory of Pharmaceutical Engineering, School of Medicine and Pharmaceutics, Jiangnan University, No. 1800 Lihu Road, Wuxi 214122, PR China.
authors.forename: Zong-Hua
authors.initials: ZH
authors.lastname: Ao
authors.forename: Zheng-Hong
authors.initials: ZH
authors.lastname: Xu
authors.forename: Zhen-Ming
authors.initials: ZM
authors.lastname: Lu
authors.forename: Hong-Yu
authors.initials: HY
authors.lastname: Xu
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Zhang
authors.forename: Wen-Fang
authors.initials: WF
authors.lastname: Dou
mesh_terms: D000818:Animals; D055491:Antrodia / Q000737:chemistry*; D003470:Culture Media; D004195:Disease Models, Animal; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D006801:Humans; D008107:Liver Diseases / Q000188:drug therapy*; D008516:Medicine, Chinese Traditional; D013624:Taiwan
chemical_list: D003470:Culture Media