title: Inherited thrombophilia and preeclampsia within a multicenter cohort: the Montreal Preeclampsia Study.
abstract: OBJECTIVE
  We sought to evaluate the association between inherited thrombophilia and preeclampsia.
  
  
  METHODS
  From a multicenter cohort of 5337 pregnant women, we prospectively identified 113 women who developed preeclampsia and selected 443 control subjects who did not have preeclampsia or nonproteinuric gestational hypertension. Blood samples were tested for DNA polymorphisms affecting thrombophilia (factor V Leiden mutation, prothrombin G20210A mutation, methylenetetrahydrofolate reductase C677T polymorphism), homocysteine, and folate levels, and placentae underwent pathological evaluation.
  
  
  RESULTS
  Thrombophilia was present in 14% of patients and 21% of control subjects (adjusted logistic regression odds ratio, 0.6; 95% confidence interval, 0.3-1.3). Placental underperfusion was present in 63% of patients vs 46% of control subjects (P < .001) and was more frequent in women with folate levels in the lowest quartile (P = .04), but was not associated with thrombophilia.
  
  
  CONCLUSIONS
  We did not find evidence to support an association between inherited thrombophilia and increased risk of preeclampsia. Placental underperfusion is associated with preeclampsia, but this does not appear to be consequent to thrombophilia.
authors.affiliation: Department of Medicine, McGill University Faculty of Medicine, Montreal, QC, Canada. susan.kahn@mcgill.ca
authors.forename: Susan R
authors.initials: SR
authors.lastname: Kahn
authors.forename: Robert
authors.initials: R
authors.lastname: Platt
authors.forename: Helen
authors.initials: H
authors.lastname: McNamara
authors.forename: Rima
authors.initials: R
authors.lastname: Rozen
authors.forename: Moy Fong
authors.initials: MF
authors.lastname: Chen
authors.forename: Jacques
authors.initials: J
authors.lastname: Genest
authors.forename: Lise
authors.initials: L
authors.lastname: Goulet
authors.forename: John
authors.initials: J
authors.lastname: Lydon
authors.forename: Louise
authors.initials: L
authors.lastname: Seguin
authors.forename: Clement
authors.initials: C
authors.lastname: Dassa
authors.forename: André
authors.initials: A
authors.lastname: Masse
authors.forename: Guylaine
authors.initials: G
authors.lastname: Asselin
authors.forename: Alice
authors.initials: A
authors.lastname: Benjamin
authors.forename: Louise
authors.initials: L
authors.lastname: Miner
authors.forename: Antoinette
authors.initials: A
authors.lastname: Ghanem
authors.forename: Michael S
authors.initials: MS
authors.lastname: Kramer
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D010920:Placenta / Q000098:blood supply; D010922:Placenta Diseases / Q000209:etiology; D011225:Pre-Eclampsia / Q000209:etiology*; D011247:Pregnancy; D011446:Prospective Studies; D011792:Quebec; D019851:Thrombophilia / Q000150:complications* / Q000235:genetics; D055815:Young Adult