Kinetic proofreading model.
Kinetic proofreading is an intrinsic property of the cell signaling process. It arises as a consequence of the multiple interactions that occur after a ligand triggers a receptor to initiate a ignaling cascade and it ensures that false signals do not propagate to completion. In order for an active signaling complex to form after a ligand binds to a cell surface receptor, a sequence of binding and phosphorylation events must occur that are rapidly reversed if the ligand dissociates from the receptor. This gives rise to a mechanism by which cells can discriminate among ligands that bind to the same receptor but form ligand-receptor complexes with different lifetimes. We review experiments designed to test for kinetic proofreading and models that exhibit kinetic proofreading.
Goldstein
Byron
B
Theoretical Biology and Biophysics Group, T-10 MS K710, Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM 875435, USA. bxg@lanl.gov
Coombs
Daniel
D
Faeder
James R
JR
Hlavacek
William S
WS
D000818:Animals; D006801:Humans; D007700:Kinetics; D008213:Lymphocyte Activation / Q000276:immunology; D018448:Models, Immunological; D017455:Receptors, IgE / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D017455:Receptors, IgE