Trick-or-treat: dietary lipids and host resistance to infectious disease.
The increased intake of omega-6 fatty acids together with the widely use of omega-3 supplements in Western diets can affect the host defence against infectious diseases. In the present review we focused on the impact of these fatty acids on salmonella and mycobacteria infection models in animals or in cell cultures. Particular attention was given to the molecular mechanisms involved.
Anes
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Molecular Pathogenesis Centre, Unit of Retrovirus and Associated Infections, Faculty of Pharmacy, University of Lisbon, Av Prof. Gama Pinto, Lisbon, Portugal. eanes@ff.ul.pt
Jordao
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D000818:Animals; D004041:Dietary Fats / Q000009:adverse effects* / Q000494:pharmacology*; D004198:Disease Susceptibility / Q000178:diet therapy; D015525:Fatty Acids, Omega-3 / Q000009:adverse effects* / Q000494:pharmacology*; D043371:Fatty Acids, Omega-6 / Q000009:adverse effects / Q000494:pharmacology; D006801:Humans; D007249:Inflammation / Q000178:diet therapy / Q000235:genetics; D012480:Salmonella Infections / Q000178:diet therapy / Q000382:microbiology; D014376:Tuberculosis / Q000178:diet therapy / Q000382:microbiology
D004041:Dietary Fats; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6