[Place of inhibin B investigation in clinical andrological praxis].
Inhibin B is a gonadal dimeric peptide, produced in men in testicular Sertolli cells. Inhibin B blood level knowledge can be a useful tool in the management of difficult diagnostic problems, such as ambiguous genitalia, the distinction between cryptorchidism and anorchidism and the hypogonadotrophic hypogonadism/delayed puberty differential diagnosis. Inhibin B measurements can help in gonadal dysgenesis evaluation, androgen insensitivity management and also in the diagnosis of some gonadal tumors. In adult men, inhibin B evaluation is helpful in the investigation of male infertility, especially in the judgment of the prognosis of testicular biopsy in in-vitro fertilization programs. Although commercial kits for inhibin B measurement are available at present, its evaluation is accessible in the Czech Republic for the time being in only very limited number of laboratory centers.
Porsová-Dutoit
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Silinkův nadacní fond Praha. endokrinologie@email.cz
D015415:Biomarkers / Q000097:blood; D006058:Gonadal Disorders / Q000175:diagnosis*; D006801:Humans; D007265:Inhibins / Q000097:blood*; D008297:Male
D015415:Biomarkers; C422364:inhibin B; D007265:Inhibins