title: Host interception of bacterial communication signals.
abstract: Pathogenic Staphylococcus aureus employs a cell-to-cell communication system to control virulence factor expression in the host during infection. In this issue, Peterson et al. (2008) report that host lipoproteins can sequester the S. aureus communication signal and antagonize virulence factor expression and pathogenesis in a murine model of infection.
authors.affiliation: Department of Microbiology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. alex-horswill@uiowa.edu
authors.forename: Alexander R
authors.initials: AR
authors.lastname: Horswill
authors.forename: William M
authors.initials: WM
authors.lastname: Nauseef
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors*; D008074:Lipoproteins / Q000276:immunology*; D051379:Mice; D010456:Peptides, Cyclic; D013203:Staphylococcal Infections / Q000276:immunology*; D013211:Staphylococcus aureus / Q000472:pathogenicity*
chemical_list: C414532:AgrD protein, Staphylococcus; D001426:Bacterial Proteins; D008074:Lipoproteins; D010456:Peptides, Cyclic