Long-term intensive insulin therapy for Japanese patients with type 2 diabetes mellitus.
OBJECTIVE
To determine the clinical usefulness of long-term intensive insulin therapy in Japanese patients with type 2 diabetes.


METHODS
Various clinical indicators and potential of withdrawal from insulin therapy were investigated in 20 type 2 diabetic patients receiving treatment in the outpatient clinic over a period of 8 years after starting intensive insulin therapy between April 1997 and March 1999.


RESULTS
The mean glycated hemoglobin (HbA1c) was approximately 6.5%, and there was no significant increase in insulin dose over a period of 8 years after commencement of intensive insulin therapy. Withdrawal from insulin therapy could be sustained in previously untreated patients.


CONCLUSIONS
Our results indicated the clinical usefulness of intensive insulin therapy over the long term in Japanese patients with type 2 diabetes and that such therapy could be especially useful for previously untreated patients.
Umezono
Tomoya
T
Internal Medicine, Division of Nephrology and Metabolism, Tokai University School of Medicine, Isehara. umechan@is.icc.u-tokai.ac.jp
Toyoda
Masao
M
Abe
Makiko
M
Kobayashi
Keiko
K
Kato
Mayuko
M
Miyauchi
Masaaki
M
Kobayashi
Takako
T
Yamamoto
Naoyuki
N
Kimura
Moritsugu
M
Yagame
Mitsunori
M
Suzuki
Daisuke
D
D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007328:Insulin / Q000008:administration & dosage* / Q000097:blood; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D007328:Insulin