title: A fluorescence detection scheme for ultra large molecules after gas phase separation.
abstract: A system was proposed to remove the upper mass limitation of mass spectrometry. In present study, ultra large molecules were separated in the gas phase by mass analyzer after electrospray ionization. Instead of conventional detection with electron multiplier, a laser-induced-fluorescence detection scheme was applied. The instrument sensitivity is independent of molecular weight, but related to the spectroscopic properties of the fluorophores presented by the large biomolecules.
authors.affiliation: Chemistry Division, MS K484, Los Alamos National Laboratory, Los Alamos, NM 87544, USA.
authors.forename: Jian
authors.initials: J
authors.lastname: He
authors.forename: Wenwan
authors.initials: W
authors.lastname: Zhong
authors.forename: Aijun
authors.initials: A
authors.lastname: Tang
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Yan
authors.forename: Cris
authors.initials: C
authors.lastname: Lewis
authors.forename: Vahid
authors.initials: V
authors.lastname: Majidi
authors.forename: Wei
authors.initials: W
authors.lastname: Hang