[Increased expression and activity of MMP-9 in chronic rhinosinusitis with nasal polyposis].
BACKGROUND
Matrix metalloproteinases (MMP) are a family of endopeptidases involved in extracellular matrix degradation and which could potentially explain specific histological changes in nasal polyposis. The aim of this study is to determine whether MMP-2 and 9 are involved in chronic rhinosinusitis with polyposis.


METHODS
Specimens were collected from 15 patients affected by nasal polyposis and 15 control patients (with turbinoplasty performed). Specimens were processed for determination of protein expression levels by Western-blot and for determination of their enzymatic activity by zymography for both MMPs.


RESULTS
Results showed a higher expression and activity of MMP-9 but not of MMP-2 in specimens from patients with polyposis when compared with controls.


CONCLUSIONS
These results support the involvement of MMP-9 in the tissue remodelling characteristic of this disease.
Eisenberg
Gustavo
G
Servicio Otorrinolaringología, Hospital de Fuenlabrada, Madrid, España. geisenberg.hflr@salud.madrid.org
Pradillo
Jesús
J
Plaza
Guillermo
G
Lizasoain
Ignacio
I
Moro
María A
MA
D000328:Adult; D015153:Blotting, Western; D002908:Chronic Disease; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D009297:Nasal Mucosa / Q000378:metabolism; D009298:Nasal Polyps / Q000453:epidemiology* / Q000378:metabolism*; D012220:Rhinitis / Q000453:epidemiology* / Q000378:metabolism*
D020780:Matrix Metalloproteinase 9