title: Large artery disease in scleroderma: case report and review of the literature.
abstract: Involvement of the large arteries in patients with systemic sclerosis (SSc) has been only rarely reported. We describe the case of a 56-year-old woman with early diffuse cutaneous SSc who presented with acute unilateral digital ischemia. Evaluation identified thrombosis at the site of a previous subclavian-to-common carotid artery bypass, rather than Raynaud's phenomenon, as the cause of ischemia. Areview of the literature indicates that large artery involvement, although a relatively uncommon clinical manifestation, can be frequently detected in the lower limbs as well as the ulnar arteries in patients with SSc.
authors.affiliation: College of Medicine, University of Illinois at Chicago.
authors.forename: A C
authors.initials: AC
authors.lastname: Rat
authors.forename: J
authors.initials: J
authors.lastname: Varga