title: Adult invasive pneumococcal disease pre- and peri-pneumococcal conjugate vaccine introduction in a tertiary hospital in Singapore.
abstract: Streptococcus pneumoniae isolates causing invasive disease at a large tertiary institute in Singapore from 2000 to 2007 were serotyped, with 84 (43.8 %) and 159 (82.8 %) isolates belonging to serotypes covered by the pneumococcal heptavalent conjugate and polysaccharide vaccines, respectively. All non-meningitis isolates were susceptible to penicillin, and the attributable mortality was 21.4 %. Patients who fulfilled the US Advisory Committee on Immunization Practices criteria for vaccination with the pneumococcal polysaccharide vaccine comprised 74.0 % of the study cohort and had a significantly higher mortality risk.
authors.affiliation: Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Li-Yang
authors.initials: LY
authors.lastname: Hsu
authors.affiliation: School of Life Sciences & Chemical Technology, Ngee Ann Polytechnic, Singapore.
authors.forename: See Weng
authors.initials: SW
authors.lastname: Lui
authors.affiliation: School of Life Sciences & Chemical Technology, Ngee Ann Polytechnic, Singapore.
authors.forename: Jia Ling
authors.initials: JL
authors.lastname: Lee
authors.affiliation: School of Life Sciences & Chemical Technology, Ngee Ann Polytechnic, Singapore.
authors.forename: Hazwany Md Mahrom
authors.initials: HMM
authors.lastname: Hedzlyn
authors.affiliation: School of Life Sciences & Chemical Technology, Ngee Ann Polytechnic, Singapore.
authors.forename: Debra Han-Lin
authors.initials: DH
authors.lastname: Kong
authors.affiliation: School of Life Sciences & Chemical Technology, Ngee Ann Polytechnic, Singapore.
authors.forename: Suku
authors.initials: S
authors.lastname: Shameen
authors.affiliation: School of Life Sciences & Chemical Technology, Ngee Ann Polytechnic, Singapore.
authors.forename: Nur Puteri Mohammad
authors.initials: NPM
authors.lastname: Siti
authors.affiliation: School of Life Sciences & Chemical Technology, Ngee Ann Polytechnic, Singapore.
authors.forename: Wei Yu
authors.initials: WY
authors.lastname: Tan
authors.affiliation: School of Life Sciences & Chemical Technology, Ngee Ann Polytechnic, Singapore.
authors.forename: Xin Yi
authors.initials: XY
authors.lastname: Toh
authors.affiliation: School of Life Sciences & Chemical Technology, Ngee Ann Polytechnic, Singapore.
authors.forename: Tse-Yuen
authors.initials: TY
authors.lastname: Koh
authors.affiliation: Singapore General Hospital, Singapore.
authors.forename: Tse-Hsien
authors.initials: TH
authors.lastname: Koh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006761:Hospitals; D006801:Humans; D008297:Male; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000517:prevention & control; D022242:Pneumococcal Vaccines / Q000276:immunology*; D012846:Singapore / Q000453:epidemiology; D013296:Streptococcus pneumoniae / Q000276:immunology; D013997:Time Factors; D014611:Vaccination; D018074:Vaccines, Conjugate / Q000276:immunology*
chemical_list: D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate