title: [Case of fulminant hepatic failure in an elderly asymptomatic HBV carrier without proximate cause].
abstract: A 82-year-old asymptomatic HBV carrier man was admitted with liver dysfunction in May 2007. With anti-HBe antibody and high viral load, he had fulminant hepatic failure without proximate cause. He was treated with entecavir and corticosteroids, but died about one month later. Autopsy specimen of liver revealed submassive hepatic necrosis with faint regeneration. HBV obtained was segregated into genotype Bj, and mutation was detected at nt1896 in a precore region.
authors.affiliation: Department of Gastroenterology, Tohoku Kosei-Nenkin Hospital.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Shiho
authors.initials: S
authors.lastname: Kondo
authors.forename: Akiko
authors.initials: A
authors.lastname: Sugawara
authors.forename: Makoto
authors.initials: M
authors.lastname: Yonechi
authors.forename: Kana
authors.initials: K
authors.lastname: Nishioka
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Meguro
authors.forename: Masahide
authors.initials: M
authors.lastname: Abe
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Murakami
authors.forename: Jun
authors.initials: J
authors.lastname: Inoue
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ueno
authors.forename: Toru
authors.initials: T
authors.lastname: Shimosegawa
mesh_terms: D000369:Aged, 80 and over; D002353:Carrier State; D017809:Fatal Outcome; D005838:Genotype; D006509:Hepatitis B / Q000188:drug therapy / Q000473:pathology / Q000821:virology; D006515:Hepatitis B virus / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D008099:Liver / Q000473:pathology / Q000821:virology; D017114:Liver Failure, Acute / Q000188:drug therapy / Q000473:pathology / Q000821:virology*; D008297:Male; D009154:Mutation; D009336:Necrosis