From molecular shape to potent bioactive agents I: bioisosteric replacement of molecular fragments.
Proschak
Ewgenij
E
Goethe-University, Institute of Organic Chemistry and Chemical Biology, LiFF/ZAFES, Siesmayerstr. 70, 60323 Frankfurt am Main, Germany.
Zettl
Heiko
H
Tanrikulu
Yusuf
Y
Weisel
Martin
M
Kriegl
Jan M
JM
Rau
Oliver
O
Schubert-Zsilavecz
Manfred
M
Schneider
Gisbert
G
D000818:Animals; D019556:COS Cells; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D003198:Computer Simulation; D015195:Drug Design; D020128:Inhibitory Concentration 50; D047493:PPAR alpha / Q000819:agonists* / Q000737:chemistry*; D047495:PPAR gamma / Q000819:agonists* / Q000737:chemistry*; D011422:Propionates / Q000737:chemistry* / Q000494:pharmacology; D012984:Software; D013329:Structure-Activity Relationship
D047493:PPAR alpha; D047495:PPAR gamma; D011422:Propionates