title: Lytic Bone Lesions as a Prominent Feature in Waldenstrom's Macroglobulinemia.
abstract: We report a patient with Waldenstrom's macroglobulinemia who had diffuse plasmacytoid infiltration in the bone marrow, immunoglobulin M monoclonal gammopathy, wide-spread osteolytic lesions, recurrent pathologic fractures, and diffuse subcutaneous soft tissue calcifications. The bony lesions were even more pronounced than those usually seen with multiple myeloma and are a rare manifestation of this disease. Such malignant plasma-cell dyscrasia with macroglobulinemia and lytic osseous lesions is best handled clinically according to its general presenting features rather than according to whether it is Waldenstrom's macroglobulinemia or an immunoglobulin M myeloma. The bone lesions may require local palliative radiotherapy and orthopedic measures.
authors.affiliation: Rheumatology Section, Department of Medicine, University of Medicine and Dentistry of New Jersey, Newark.
authors.forename: N
authors.initials: N
authors.lastname: Schlesinger
authors.forename: L
authors.initials: L
authors.lastname: Neustadter
authors.forename: H R
authors.initials: HR
authors.lastname: Schumacher