Prevalence of hepatitis D virus infection in HBsAg positive subjects in Iran.
This study was carried out to determine the seroprevalence of hepatitis D virus among HBsAg positive individuals in the northeast part of Iran. One hundred thirty nine HBsAg positive subjects detected from a population based single stage cluster sampling in Golestan province of Iran were enrolled. All cases were evaluated for the presence of anti-HDV antibodies using commercially available ELISA kits. Logistic regression was used to determine the relationship between independent variables and HDV seropositivity. Of 139 cases, 68 (48.9%) were males and 71 (51.1%) were females. The mean age was 41.89 +/- 11.30 years (25-64 years). Anti-HDV antibody was positive in 8 (5.8%) subjects with female predominance (9.9% versus 1.5%, p = 0.06; odds ratio = 7.32, 95% CI: 0.87-61.23). No significant relationship was seen between anti-HDV seropositivity and demographic factors such as age, place of residence and marital status. These findings showed that HDV infection was endemic in Golestan province (northeast) of Iran. Seroprevalence of Anti-HDV in the present study was higher than some previous studies from other parts of Iran. Our results suggest that the prevalence of HBV/HDV co-infection in Iran has increased during the last decade. Therefore, practitioners and all health care managers should be made aware of the risk of dual infection with HBV and HDV.
Roshandel
Gholamreza
G
Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Golestan Province, Iran.
Semnani
Shahryar
S
Abdolahi
Nafiseh
N
Keshtkar
Abbas-Ali
AA
Besharat
Sima
S
Joshaghani
Hamidreza
H
Moradi
Abdolvahab
A
Kalavi
Khodaberdi
K
Jabbari
Ali
A
Kabir
Mohammad Javad
MJ
Hosseini
Seyed Ahmad
SA
Sedaqat
Seyed Mehdi
SM
Danesh
Ahmad
A
Roshandel
Danial
D
Hedayat-Mofidi
Seyed Mohammad
SM
D000328:Adult; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D003699:Hepatitis D / Q000453:epidemiology* / Q000276:immunology; D006801:Humans; D007492:Iran / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015995:Prevalence
D006514:Hepatitis B Surface Antigens