title: [The role of extracellular chaperone Hsp70 in creating antitumor immunity in rat rhabdomyosarcoma RA-2 model].
abstract: Immunization of experimental animals with extract or membranes of rat rhabdomyosarcoma RA-2 in combination with pure Hsp70 did not offer any significant effect of protection from subsequent RA-2 cells-stimulated tumor growth. By contrast, immunization with preparations of pure Hsp70 led to a significant decrease in number and size of tumors as well as elevation of concentrations of antibodies against RA-2 cells. Also, enhanced blood levels of Hsp70 involved delayed tumor growth. In vitro tests Hsp70 incubation with RA-2 cells was followed by a 30-35% rise in cytotoxic lymphocytes levels. An ability of pure Hsp70 preparations to stimulate humoral and antitumor response was demonstrated. Hence, they may be used in developing vaccine formulas.
authors.forename: I V
authors.initials: IV
authors.lastname: Guzhova
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Komarova
authors.forename: A A
authors.initials: AA
authors.lastname: Pimenova
authors.forename: Iu B
authors.initials: IuB
authors.lastname: Bakhtin
authors.forename: E V
authors.initials: EV
authors.lastname: Kaminskaia
authors.forename: B A
authors.initials: BA
authors.lastname: Margulis
mesh_terms: D000818:Animals; D019496:Cancer Vaccines / Q000008:administration & dosage* / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000008:administration & dosage* / Q000097:blood / Q000276:immunology / Q000378:metabolism*; D008297:Male; D051381:Rats; D012208:Rhabdomyosarcoma / Q000276:immunology*
chemical_list: D019496:Cancer Vaccines; D018840:HSP70 Heat-Shock Proteins