[Accessory gene regulator in Staphylococcus biofilm formation and infection].
The most important factor in the pathogenesis of biomaterial-associated Staphylococcal infections is the formation of bacterial biofilms. Biofilm formation was regulated or influenced by quorum sensing. One of the quorum sensing systems agr is genus specific which controls the expression of a series of toxins and virulence factors and the interaction with the innate immune system. New research indicates that the role of agr during infection is controversial. The research progress will play an important role in the development of novel antibacterial agents and management of device-related infection of Staphylococci.
Tang
Jun-ni
JN
Bioengineering Research Center for Animal Disease Prevention and Control, School of Life Sciences, Sichuan University, Chengdu 610065, China.
Zhou
Rui
R
Wang
Hong-ning
HN
Zeng
Zhi-guang
ZG
D001426:Bacterial Proteins / Q000502:physiology*; D001672:Biocompatible Materials; D018441:Biofilms / Q000254:growth & development*; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D015398:Signal Transduction / Q000235:genetics; D013203:Staphylococcal Infections / Q000382:microbiology*; D013210:Staphylococcus / Q000235:genetics / Q000502:physiology*; D015534:Trans-Activators / Q000502:physiology*
C095698:Agr protein, Staphylococcus aureus; D001426:Bacterial Proteins; D001672:Biocompatible Materials; D015534:Trans-Activators