Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, and hydroxytyrosol.
Resveratrol increases longevity through SirT1, which is activated with NAD(+) supplied by an anti-aging enzyme PBEF. SirT1 interacts with an anti-aging transcription factor, FoxO1, which is negatively regulated by Akt. Since white wine could have similar health benefits as red wine, we determined if white wine and its cardioprotective components possess anti-aging properties by feeding rats with these compounds. The hearts expressed SirT, FoxO, and PBEF in the order of white wine>resveratrol>tyrosol>hydroxytyrosol>red wine, while cardioprotection shown by reduction of infarct size and cardiomyocyte apoptosis followed a different pattern: resveratrol>red wine>hydroxytyrosol>white wine>tyrosol, suggesting the existence of different signaling mechanisms for the induction of longevity and survival.
Mukherjee
Subhendu
S
Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, 06030-1110, USA.
Lekli
Istvan
I
Gurusamy
Narasimman
N
Bertelli
Alberto A A
AA
Das
Dipak K
DK
D000375:Aging; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002316:Cardiotonic Agents / Q000008:administration & dosage* / Q000737:chemistry; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000378:metabolism; D020287:In Situ Nick-End Labeling; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D054409:Nicotinamide Phosphoribosyltransferase / Q000235:genetics / Q000378:metabolism; D051058:Oncogene Protein v-akt / Q000235:genetics / Q000378:metabolism; D010626:Phenylethyl Alcohol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000378:metabolism* / Q000473:pathology / Q000517:prevention & control; D000077185:Resveratrol; D015398:Signal Transduction; D037761:Sirtuins / Q000235:genetics / Q000378:metabolism; D013267:Stilbenes / Q000008:administration & dosage* / Q000737:chemistry; D015533:Transcriptional Activation; D014920:Wine; D000071161:Forkhead Box Protein O1
D002316:Cardiotonic Agents; D051858:Forkhead Transcription Factors; D009419:Nerve Tissue Proteins; D054409:Nicotinamide Phosphoribosyltransferase; D051058:Oncogene Protein v-akt; D010626:Phenylethyl Alcohol; D000077185:Resveratrol; D037761:Sirtuins; D013267:Stilbenes; C005975:3,4-dihydroxyphenylethanol; C074639:Foxo1 protein, rat; D000071161:Forkhead Box Protein O1; C011867:4-hydroxyphenylethanol