Plasma natriuretic peptides levels and echocardiographic findings in late subclinical anthracycline toxicity.
The purpose of this study was to evaluate late cardiac toxicity by comprehensive echocardiographic study, and to determine whether plasma atrial natriuretic peptide and brain natriuretic peptide levels might be indicators of neurohumoral activation. The study included 49 long-term survivors and 21 controls. A wide variety of echocardiographic parameters were measured or calculated. Plasma peptide levels were determined. Patients had significant changes in different echocardiographic parameters that are suggestive of LV systolic and diastolic dysfunction. Plasma peptide levels were not increased. The authors have found significant subclinic cardiotoxicity by echocardiography. Survivors seem to have normal plasma natriuretic peptide levels in long-term period.
Kantar
Mehmet
M
Pediatric Oncology, Ege University School of Medicine Department of Pediatrics, Izmir, Turkey. mehmet.kantar@ege.edu.tr
Levent
Erturk
E
Cetingul
Nazan
N
Ulger
Zulal
Z
Ozyurek
Ruhi
R
Aksoylar
Serap
S
Kansoy
Savas
S
D000293:Adolescent; D018943:Anthracyclines / Q000009:adverse effects* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D009320:Atrial Natriuretic Factor / Q000097:blood*; D054715:Cardiotoxins / Q000009:adverse effects*; D002648:Child; D003430:Cross-Sectional Studies; D003520:Cyclophosphamide / Q000009:adverse effects* / Q000627:therapeutic use; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D018487:Ventricular Dysfunction, Left / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis* / Q000000981:diagnostic imaging
D018943:Anthracyclines; D000970:Antineoplastic Agents; D054715:Cardiotoxins; D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor; D003520:Cyclophosphamide