title: Diffuse hemangiomatosis with predominant central nervous system involvement.
abstract: Diffuse neonatal hemangiomatosis presents with multiple, progressive, rapidly growing cutaneous hemangiomas associated with widespread visceral hemangiomas in the liver, lungs, gastrointestinal tract, brain, and meninges. Described here is a case of diffuse neonatal hemangiomatosis with predominant central nervous system involvement. The early appearance of central nervous system lesions on imaging can overlap with that of cavernous malformations, confounding diagnosis; however, rapid growth, response to steroids, cystic appearance with sedimentation levels of the mature lesions, and involvement of other visceral organs can help confirm the diagnosis.
authors.affiliation: Section of Neurology, Department of Internal Medicine, University of Manitoba, Health Sciences Centre, Winnipeg, Manitoba, Canada.
authors.forename: Atheer
authors.initials: A
authors.lastname: Al-Kaabi
authors.forename: Rochelle
authors.initials: R
authors.lastname: Yanofsky
authors.forename: Martin
authors.initials: M
authors.lastname: Bunge
authors.forename: Jeff
authors.initials: J
authors.lastname: Hyman
authors.forename: Mubeen F
authors.initials: MF
authors.lastname: Rafay
mesh_terms: D020787:Central Nervous System Venous Angioma / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D003907:Dexamethasone / Q000627:therapeutic use; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D020786:Hemangioma, Cavernous, Central Nervous System / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D003907:Dexamethasone