title: Permissive hypercapnia.
abstract: Mechanical ventilation using high tidal volume (VT) and transpulmonary pressure can damage the lung, causing ventilator-induced lung injury. Permissive hypercapnia, a ventilatory strategy for acute respiratory failure in which the lungs are ventilated with a low inspiratory volume and pressure, has been accepted progressively in critical care for adult, pediatric, and neonatal patients requiring mechanical ventilation and is one of the central components of current protective ventilatory strategies.
authors.affiliation: Pediatric Research in Emergency Therapeutics (PRETx) Program, Division of Pediatric Emergency Medicine, Ambulatory Care Building, BC Children's Hospital, 4480 Oak Street, Vancouver, BC, Canada.
authors.forename: Alex
authors.initials: A
authors.lastname: Rogovik
authors.forename: Ran
authors.initials: R
authors.lastname: Goldman
mesh_terms: D000142:Acidosis, Respiratory / Q000209:etiology / Q000276:immunology / Q000378:metabolism*; D000328:Adult; D002021:Buffers; D006801:Humans; D006935:Hypercapnia / Q000150:complications / Q000209:etiology / Q000503:physiopathology*; D007040:Hypoventilation; D007231:Infant, Newborn; D015337:Multicenter Studies as Topic; D010372:Pediatrics; D011175:Positive-Pressure Respiration / Q000379:methods*; D016032:Randomized Controlled Trials as Topic; D012121:Respiration, Artificial / Q000009:adverse effects* / Q000379:methods*; D012128:Respiratory Distress Syndrome / Q000401:mortality / Q000628:therapy*; D012127:Respiratory Distress Syndrome, Newborn / Q000628:therapy*; D018805:Sepsis / Q000628:therapy*; D013224:Status Asthmaticus / Q000628:therapy*
chemical_list: D002021:Buffers