Malignant transformation of donovanosis (granuloma inguinale) in a HIV-positive patient.
Donovanosis is endemic in various parts of the world. Although donovanosis has been reported to co-exist with the human immunodeficiency virus (HIV) infection, to our knowledge there have been no reports of co-existent squamous cell carcinoma (SCC) in an HIV positive patient. In our case the patient did not respond to treatment for donovanosis and on biopsy we realized that the patient had coexistent SCC, which is hitherto unreported with granuloma inguinale.
Sardana
Kabir
K
Dermatology, Maulana Azad Medical College, Delhi, India. kabirijdvl@gmail.com
Garg
Vijay K
VK
Arora
Pooja
P
Khurana
Neeta
N
D000671:Amputation, Surgical; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000473:pathology / Q000628:therapy; D002471:Cell Transformation, Neoplastic; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D018450:Disease Progression; D004318:Doxycycline / Q000627:therapeutic use; D006100:Granuloma Inguinale / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D015658:HIV Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D008297:Male; D010412:Penile Neoplasms / Q000150:complications* / Q000473:pathology / Q000628:therapy; D018714:Radiotherapy, Adjuvant; D012878:Skin Neoplasms / Q000150:complications* / Q000473:pathology / Q000628:therapy; D012883:Skin Ulcer / Q000209:etiology; D055815:Young Adult
D000900:Anti-Bacterial Agents; D019380:Anti-HIV Agents; D004318:Doxycycline