title: Overexpression of pulmonary surfactant protein A like molecules in inflammatory bowel disease tissues.
abstract: OBJECTIVE
  To investigate the distribution of pulmonary surfactant protein A (SP-A) like molecules and the bridge of frontier host defense and adaptive immune response cell of CD68 positive macrophages in inflammatory bowel disease (IBD).
  
  
  METHODS
  Surgical specimens derived from involved areas and normal area of the colon with Crohn disease (CD) and ulcerative colitis (UC) were obtained from Department of Pathology, Rhode Island Hospital, Brown University Medical Center. The distribution of SP-A like molecule in intestine of IBD was detected by immunohistochemistry.
  
  
  RESULTS
  SP-A like molecule located in epithelia of intestine, the surface of intestine villi, blood vessels of connective tissue, and some inflammatory cells. The number of macrophages with both SP-A like molecule and CD68 positive was dramatically increased in the inflammatory area than the normal area. Some CD68 positive macrophages expressed SP-A like immunoreactivity by immunofluorescence double labeling.
  
  
  CONCLUSIONS
  SP-A is an important host defense molecule in lung, and SP-A expression in large intestine may reflect a close relation between 2 organs in immune response towards inflammation.
authors.affiliation: Kidney Institute, Department of Medicine, University of Kansas, Kansas City, KS 66160, USA. jluo099@yahoo.com
authors.forename: Jun-ming
authors.initials: JM
authors.lastname: Luo
authors.forename: Zhao-qian
authors.initials: ZQ
authors.lastname: Liu
authors.forename: Chin Y
authors.initials: CY
authors.lastname: Eugene
mesh_terms: D015703:Antigens, CD / Q000378:metabolism*; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism*; D003093:Colitis, Ulcerative / Q000276:immunology / Q000378:metabolism; D003106:Colon / Q000378:metabolism; D003424:Crohn Disease / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D015212:Inflammatory Bowel Diseases / Q000276:immunology / Q000378:metabolism*; D008264:Macrophages / Q000276:immunology / Q000378:metabolism*; D037661:Pulmonary Surfactant-Associated Proteins / Q000235:genetics / Q000378:metabolism*; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D037661:Pulmonary Surfactant-Associated Proteins; C067980:CD68 antigen, human; D000097382:CD68 Molecule