Ordered mesoporous silica material SBA-15: a broad-spectrum formulation platform for poorly soluble drugs.
Encapsulating poorly soluble drugs in mesoporous silicates is an emerging strategy to improve drug dissolution. This study evaluates the applicability of the ordered mesoporous silicate SBA-15 as an excipient to enhance dissolution, for a test series of 10 poorly soluble compounds with a high degree of physicochemical diversity (carbamazepine, cinnarizine, danazol, diazepam, fenofibrate, griseofulvin, indomethacin, ketoconazole, nifedipine, and phenylbutazone). A generic solvent impregnation method was used to load all model compounds. The target drug content was 20%. The physical nature of the formulations was investigated using differential scanning calorimetry (DSC) and the pharmaceutical performance evaluated by means of in vitro dissolution. Aliquots of each formulation were stored at 25 degrees C/52% RH for 6 months, and again subjected to DSC and in vitro dissolution. The target drug content of 20% was attained in all cases. DSC data evidenced the noncrystalline state of the confined drugs. All SBA-15 formulations exhibited an enhanced dissolution as compared to their corresponding crystalline materials, and the high pharmaceutical performance of all formulations was retained during the 6 months storage period. The results of this study suggest that encapsulation in SBA-15 can be applied as a dissolution-enhancing formulation approach for a very wide variety of poorly soluble drugs.
Van Speybroeck
Michiel
M
Laboratory for Pharmacotechnology and Biopharmacy, K.U. Leuven, Belgium.
Barillaro
Valéry
V
Thi
Thao Do
TD
Mellaerts
Randy
R
Martens
Johan
J
Van Humbeeck
Jan
J
Vermant
Jan
J
Annaert
Pieter
P
Van den Mooter
Guy
G
Augustijns
Patrick
P
D002626:Chemistry, Pharmaceutical; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000378:metabolism; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry* / Q000378:metabolism*; D012995:Solubility
D004364:Pharmaceutical Preparations; C509969:SBA-15; D012822:Silicon Dioxide