[Liver transplantation: influence of donor-related factors].
OBJECTIVE
To detect donor characteristics related to graft function after orthotopic liver transplantation (OLT).


METHODS
Retrospective cohort study.


BACKGROUND
Polyvalent intensive care unit.


METHODS
145 liver transplant recipients and their respective donors.


METHODS
None.


METHODS
In donors: age, hypernatremia, and infection. In recipients: reperfusion syndrome, coagulopathy, infection, ARDS, shock, kidney failure, primary graft dysfunction, and mortality.


RESULTS
71.7% of recipients were male. Mean recipient age was 54.5 +/- 9.9 years; 66.2% of patients were classified as Child B and and 19.3% as Child C. The mean model for end-stage liver disease (MELD) score was 14.6 +/- 4.8 and the mean APACHE II score was 17.3 +/- 4.9. A total of 64.1% of the donors were male. Mean donor age was 42.3 +/- 16.3 years, and mean APACHE II score was 22.3 +/- 5.8. Donor age > 65 years was associated to higher recipient aspartate aminotransferase (AST) levels but not to increased complications or mortality. No other donor factors (including age, sex, serum sodium, severity level, transfusions, hemodynamic alterations, renal dysfunction, or infection) were associated to evolution or prognosis. Infection was diagnosed in 18 recipients (12.4%) in the postoperative period; the incidence of infection in recipients that received an organ from infected donors was not different from those that received an organ from an uninfected donor (14.6% versus 11.5%; p > 0.05).


CONCLUSIONS
We detected no donor characteristics related to graft function or the appearance of complications in recipients during the immediate postoperative period. Donor age > 65 years and documented but appropriately treated bacteremia posed no risk for the viability of the liver after transplantation.
Seller-Pérez
G
G
Servicio de Cuidados Críticos y Urgencias. Complejo Universitario Hospitalario Carlos Haya. Málaga. España. gemmaseller@gmail.com
Herrera-Gutiérrez
M E
ME
Lebrón-Gallardo
M
M
Moreno-Quintana
J
J
Banderas-Bravo
E
E
Quesada-García
G
G
D000328:Adult; D015331:Cohort Studies; D005260:Female; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology; D012189:Retrospective Studies; D014019:Tissue Donors