title: Acute myocardial infarction after treatment of thrombocytopenia in a young woman with systemic lupus erythematosus.
abstract: We describe a case of an acute myocardial infarction (MI) coincident with correction of severe thrombocytopenia in a 23-year old African American woman with systemic lupus erythematosus (SLE) in the absence of coronary artery disease on angiography. Despite a history of anticardiolipin and beta(2)-glycoprotein I antibodies, she had no prior thromboembolic events. The occurrence of an acute MI after rapid normalization in the platelet count suggests the need for close monitoring of possible cardiovascular events during and after treatment of severe thrombocytopenia in the presence of antiphospholipid antibodies.
authors.affiliation: Northwestern University, Feinberg School of Medicine, Division of Rheumatology, McGaw Pavilion, Chicago, IL 60611, USA.
authors.forename: Susanna
authors.initials: S
authors.lastname: Tan
authors.forename: Siddharth
authors.initials: S
authors.lastname: Tambar
authors.forename: Saima
authors.initials: S
authors.lastname: Chohan
authors.forename: Rosalind
authors.initials: R
authors.lastname: Ramsey-Goldman
authors.forename: Chin
authors.initials: C
authors.lastname: Lee
mesh_terms: D017152:Antibodies, Antiphospholipid / Q000097:blood; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000009:adverse effects / Q000627:therapeutic use; D007155:Immunologic Factors / Q000009:adverse effects / Q000627:therapeutic use; D007783:Lactones / Q000009:adverse effects / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000276:immunology; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology*; D012307:Risk Factors; D013450:Sulfones / Q000009:adverse effects / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000097:blood / Q000150:complications* / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D017152:Antibodies, Antiphospholipid; D016861:Cyclooxygenase Inhibitors; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors; D007783:Lactones; D013450:Sulfones; C116926:rofecoxib