The use of radiotherapy for the treatment of localized orbital amyloidosis.
OBJECTIVE
To describe two patients with localized orbital amyloidosis and the response of their condition to surgical debulking followed by external beam radiotherapy.


METHODS
Retrospective noncomparative interventional case series.


METHODS
Stabilization or regression of orbital signs after treatment.


METHODS
Patients with biopsy-proven diagnosis of localized progressive orbital amyloidosis received 34 and 30 Gy fractionated external beam radiotherapy. The clinical case notes and histopathology for the two patients were reviewed.


RESULTS
A 69-year-old man with orbital amyloid deposition in association with localized MALT lymphoma had a marked improvement in orbital signs following surgical debulking and radiotherapy, with no recurrence over two years. A 59-year-old woman with localized orbital amyloidosis showed regression of disease after surgical debulking and radiotherapy, with no evidence of recurrence after six years of follow-up.


CONCLUSIONS
External beam radiotherapy following surgical debulking appears to halt the progression of localized orbital amyloidosis. Radiotherapy may be used in conjunction with surgical debulking of disease.
Khaira
Mandip
M
Department of Medical Oncology, St. Bartholomew's Hospital, London, UK.
Mutamba
Antony
A
Meligonis
George
G
Rose
Geoffrey E
GE
Plowman
Piers N
PN
O'Donnell
Helen
H
D000368:Aged; D000686:Amyloidosis / Q000175:diagnosis / Q000532:radiotherapy* / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013508:Ophthalmologic Surgical Procedures; D009916:Orbital Diseases / Q000175:diagnosis / Q000532:radiotherapy* / Q000601:surgery; D020266:Radiotherapy, Conformal; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed