title: Antibacterial effects of water soluble green tea extracts on multi-antibiotic resistant isolates of Pseudomonas aeruginosa.
abstract: In this research we evaluated the antibacterial activity of water soluble green tea extracts on 43 hospital isolates of Pseudomonas aeruginosa. A total of 43 strains of Pseudomonas aeruginosa were collected from clinical specimens at two hospitals in Tehran, Iran. The susceptibilities of isolates to different antibiotics were tested using agar disk diffusion method. Antibacterial activity of water soluble green tea extract was measured by Minimum Inhibitory Concentrations (MICs) and Minimum Bactericidal Concentrations (MBCs). 35.6% of isolated strains showed resistance to 5 antibiotics or more and 55.8% of all strains were Multi-Drug Resistant (MDR) strains. The average MICs and MBCs of the extract against all strains of Pseudomonas auroginosa were 2.06 +/- 1.76 and 2.54 +/- 2.22 mg mL(-1) respectively.Our study suggests that green tea has significant activity with bactericidal action on multi-drug resistant strains of Pseudomonas aeruginosa.
authors.affiliation: Department of Microbiology, Immunology and Genetics, Faculty of Medicine, Urmia Medical Sciences University, Urmia, Iran.
authors.forename: N Hosseini
authors.initials: NH
authors.lastname: Jazani
authors.forename: Sh
authors.initials: Sh
authors.lastname: Shahabi
authors.forename: A Abdi
authors.initials: AA
authors.lastname: Ali
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification / Q000502:physiology*; D013662:Tea / Q000737:chemistry*; D014867:Water
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts; D013662:Tea; D014867:Water