title: [Effects of ramipril and simvastatin on the oxidative stress of diabetic rats].
abstract: OBJECTIVE
  To evaluate if ramipril, with or without simultaneous use of simvastatin, would be capable of reducing oxidative stress of streptozotocin (STZ) induced diabetic rats.
  
  
  METHODS
  The drugs were given to the diabetic rats for 2 weeks; oxidative stress was measured by dosage of total plasma antioxidant capacity (TRAP) and malondialdehyde (MDA).
  
  
  RESULTS
  Ramipril, used alone, was capable of significantly increasing the antioxidative defenses of the diabetic rat; simvastatin, given alone or combined with ramipril in separate administrations, did not produce any significant effect on the oxidative stress; concomitant administration of ramipril and simvastatin significantly reduced the antioxidative plasmatic defenses of rats with chemically induced diabetes mellitus
  
  
  CONCLUSIONS
  Our data corroborate the positive effect of ramipril upon plasma antioxidative defenses but did not confirm a possible beneficial effect of simvastatin in the model. More research is needed to clarify the paradoxal TRAP reduction verified with simultaneous administration of the drugs.
authors.affiliation: Departamento de Farmácia, Universidade Norte do Paraná, Londrina, PR, Brasil. jazelias@yahoo.com.br
authors.forename: José A Z
authors.initials: JA
authors.lastname: Elias
authors.forename: Vinicius D A
authors.initials: VD
authors.lastname: Delfino
authors.forename: Décio S
authors.initials: DS
authors.lastname: Barbosa
authors.forename: Bruno A
authors.initials: BA
authors.lastname: Fabris
authors.forename: Tiemi
authors.initials: T
authors.lastname: Matsuo
mesh_terms: D000704:Analysis of Variance; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage*; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism*; D004353:Drug Evaluation, Preclinical; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D017257:Ramipril / Q000008:administration & dosage*; D011897:Random Allocation; D051381:Rats; D019821:Simvastatin / Q000008:administration & dosage*; D018709:Statistics, Nonparametric
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000975:Antioxidants; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D019821:Simvastatin; D017257:Ramipril