Hyaluronan-mediated motility receptor gene single nucleotide polymorphisms and risk of breast cancer.
A recent study used a network modeling strategy to generate a set of genes linked by potential functional associations. The hyaluronan-mediated motility receptor (HMMR) gene was identified as being as functionally associated with BRCA1 and thus a candidate breast cancer gene. SNPs rs10515860, rs299290, and rs7712023 were reported to be significantly associated with breast cancer in a joint analysis of two small case-control studies. We have examined the association of these single nucleotide polymorphisms, together with others tagging the HMMR gene, in a larger, European case-control study and find no association of any of them with risk of breast cancer: rs10515860 [odds ratio (OR; AA/GG), 0.85; 95% confidence interval (CI), 0.65-1.12; P(trend) = 0.9], rs299290 [OR (CC/TT), 1.00; 95% CI, 0.87-1.15; P(trend) = 0.7], rs3756648 (rs7712023) [OR (TT/CC), 0.93; 95% CI, 0.84-1.02; P(trend) = 0.1], rs299284 [OR (TT/CC), 1.01; 95% CI, 0.76-1.35; P(trend) = 0.5], and rs13183712 [OR (TT/GG), 1.04; 95% CI, 0.88-1.23; P(trend) = 0.6].
Kalmyrzaev
Bolot
B
University of Cambridge Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN United Kingdom. bolot.kalmyrzaev@srl.cam.ac.uk
Pharoah
Paul D P
PD
Easton
Douglas F
DF
Ponder
Bruce A J
BA
Dunning
Alison M
AM
D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D004739:England; D016326:Extracellular Matrix Proteins / Q000235:genetics*; D005189:False Positive Reactions; D005260:Female; D005838:Genotype; D006801:Humans; D018960:Hyaluronan Receptors / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012306:Risk
D016326:Extracellular Matrix Proteins; D018960:Hyaluronan Receptors; C098946:hyaluronan-mediated motility receptor