Novel nonstatin strategies to lower low-density lipoprotein cholesterol.
There remains an unmet need to reduce elevated low-density lipoprotein cholesterol (LDL-C) in patients who are maximized on current therapy or intolerant to statins. Several novel agents have been developed to lower LDL-C, either as monotherapy or in combination with statins. These novel therapies include squalene synthase inhibitors, microsomal triglyceride transfer protein inhibitors, and antisense apolipoprotein B. Although each of these novel therapies effectively lowers LDL-C, challenges remain in the clinical development to assess long-term safety.
Davidson
Michael H
MH
Radiant Research, 515 North State Street, Suite 2700, Chicago, IL 60654, USA. michaeldavidson@radiantresearch.com
D000818:Animals; D000924:Anticholesteremic Agents / Q000627:therapeutic use; D001384:Azetidines / Q000627:therapeutic use; D001562:Benzimidazoles / Q000627:therapeutic use; D002352:Carrier Proteins / Q000037:antagonists & inhibitors; D008078:Cholesterol, LDL / Q000097:blood*; D000069438:Ezetimibe; D013186:Farnesyl-Diphosphate Farnesyltransferase / Q000037:antagonists & inhibitors; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy*; D007211:Indoles / Q000627:therapeutic use; D009841:Oligonucleotides / Q000627:therapeutic use; D010077:Oxazepines / Q000627:therapeutic use; D010880:Piperidines / Q000627:therapeutic use; D000071449:Proprotein Convertase 9; D043484:Proprotein Convertases; D011725:Pyridines / Q000627:therapeutic use; D012697:Serine Endopeptidases; D015842:Serine Proteinase Inhibitors / Q000627:therapeutic use
C466644:1-((1-(3-acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl)acetyl)piperidine-4-acetic acid; D000924:Anticholesteremic Agents; D001384:Azetidines; C473731:BMS201038; D001562:Benzimidazoles; D002352:Carrier Proteins; D008078:Cholesterol, LDL; D007211:Indoles; D009841:Oligonucleotides; D010077:Oxazepines; D010880:Piperidines; D011725:Pyridines; D015842:Serine Proteinase Inhibitors; C106092:microsomal triglyceride transfer protein; C524142:mipomersen; D013186:Farnesyl-Diphosphate Farnesyltransferase; C472125:PCSK9 protein, human; D000071449:Proprotein Convertase 9; D043484:Proprotein Convertases; D012697:Serine Endopeptidases; D000069438:Ezetimibe; C443181:implitapide