title: Mastocytosis with urticaria pigmentosa and osteoporosis.
abstract: A 76-year-old man with a 52-year history of urticaria pigmentosa was found to have an elevated serum tryptase level as well as osteoporosis. Histopathologic alterations of one his skin lesions showed an infiltrate of mast cells. Urticaria pigmentosa patients are at risk for osteoporosis because of elevated heparin and stem-cell factor levels. These patients should be screened with serum tryptase levels and bone density studies to detect osteoporosis, regardless of their age.
authors.affiliation: Department of Dermatology, New York University, USA.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Stein
authors.forename: Hideko
authors.initials: H
authors.lastname: Kamino
authors.forename: Ruth F
authors.initials: RF
authors.lastname: Walters
authors.forename: Miriam K
authors.initials: MK
authors.lastname: Pomeranz
mesh_terms: D000368:Aged; D015415:Biomarkers; D001706:Biopsy; D015519:Bone Density; D006801:Humans; D008297:Male; D008407:Mast Cells / Q000473:pathology; D010024:Osteoporosis / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D012867:Skin / Q000473:pathology; D053802:Tryptases / Q000097:blood; D014582:Urticaria Pigmentosa / Q000150:complications* / Q000175:diagnosis / Q000473:pathology
chemical_list: D015415:Biomarkers; D053802:Tryptases