Synthesis and DNA cleavage activity of a bifunctional intercalator-linked copper(II) macrocycle.
An intercalator-linked macrocycle 3,6-bis(dimethylamino)-10-(6-[1,4,7-triazacyclononane]hexyl) acridinium bromide was synthesized, its copper(ii) complex was prepared, and the DNA cleavage activity of this metal complex was compared to that of the intercalator-free (Cu[9]aneN(3))(2+) complex.
Tseng
Ta-Sheng Andrew
TS
Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.
Burstyn
Judith N
JN
D003300:Copper / Q000737:chemistry*; D053837:DNA Cleavage; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
D047028:Macrocyclic Compounds; D003300:Copper