title: Extensive screening for plant foodstuffs in Okinawa, Japan with anti-obese activity on adipocytes in vitro.
abstract: To search for plant foodstuffs with potent anti-obese activity, we conducted a large scale screening based on the inhibitory activity on adipogenesis and the facilitating activity on adipolysis in vitro. That is, inhibition of intracellular lipid accumulation and facilitation of lipid degradation in 3T3-L1 adipocytes were extensively screened from ethanol and hexane extracts of approximately 100 kinds of plant foodstuffs marketed in Okinawa prefecture, which has been famous for the highest prevalence of exceptionally long-lived individuals in the world. Among them thirty one foodstuffs showed potent inhibitory activity on intracellular lipid accumulation in 3T3-L1 adipocytes, whereas only four foodstuffs showed clear facilitating effect on lipid degradation in 3T3-L1 adipocytes. Although further study to examine the in vivo effects on adipogenesis and adipolysis is required, this is the first study to investigate anti-obese characteristics of wide range of traditional Okinawa foodstuffs so that the results give useful information to take another look at Okinawa food culture.
authors.affiliation: Research Center for Functional Food Materials, Sunny Health Holdings Co., Ltd., Saito Biotechnology Incubator, 7-7-15 Saito-Asagi, Ibaraki, Osaka, 567-0085, Japan. y.niwano@sunnyhealth.co.jp
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Niwano
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Beppu
authors.forename: Taichi
authors.initials: T
authors.lastname: Shimada
authors.forename: Rika
authors.initials: R
authors.lastname: Kyan
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Yasura
authors.forename: Minori
authors.initials: M
authors.lastname: Tamaki
authors.forename: Michinori
authors.initials: M
authors.lastname: Nishino
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Midorikawa
authors.forename: Hiroki
authors.initials: H
authors.lastname: Hamada
mesh_terms: D041721:3T3-L1 Cells; D017667:Adipocytes / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism*; D050156:Adipogenesis / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D006801:Humans; D007564:Japan; D050356:Lipid Metabolism / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D019440:Anti-Obesity Agents; D010936:Plant Extracts