Distinct cytokine patterns in the aqueous humor of children, adolescents and adults with uveitis.
OBJECTIVE
To determine the immune mediator profile in relation to age in the aqueous humor (AqH) of patients with uveitis.


METHODS
AqH of children, adolescents, and adults with uveitis was analyzed for 16 immune mediators.


RESULTS
No significant differences were found for IL-8, RANTES, and IP-10. The concentrations of the remaining 13 mediators were significant lower in adults compared with children and adolescents, except for IL-6, which was higher.


CONCLUSIONS
Various immune mediators are present in higher concentrations in AqH of children and adolescents with different uveitis entities compared with that of adults, except IL-6, which was higher in adults.
Sijssens
Karen M
KM
Department of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands. k.sijssens@umcutrecht.nl
Rijkers
Ger T
GT
Rothova
Aniki
A
Stilma
Jan S
JS
de Boer
Joke H
JH
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001082:Aqueous Humor / Q000378:metabolism*; D018925:Chemokines / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D006801:Humans; D007118:Immunoassay; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D014605:Uveitis / Q000378:metabolism*; D055815:Young Adult
D018925:Chemokines; D016207:Cytokines