Low dosage cidofovir without probenecid as treatment for BK virus hamorrhagic cystitis after hemopoietic stem cell transplant.
We describe a single-center pediatric experience with 1 mg/kg/wk cidofovir without probenecid in 7 children with BK virus-associated hemorrhagic cystitis. Clinical improvement was observed in all cases, without adverse events, although significant reduction of urinary viral load was observed 2 weeks after the end of cidofovir in 5 out of 6 patients who completed the treatment.
Faraci
Maura
M
Department of Haematology and Oncology, "G. Gaslini" Children Hospital, Genoa, Italy.
Cuzzubbo
Daniela
D
Lanino
Edoardo
E
Di Marco
Eddi
E
Cirillo
Carmela
C
Dallorso
Sandro
S
Morreale
Giuseppe
G
Moroni
Cristina
C
Castagnola
Elio
E
D000293:Adolescent; D000998:Antiviral Agents / Q000008:administration & dosage*; D001739:BK Virus / Q000302:isolation & purification*; D002648:Child; D002675:Child, Preschool; D000077404:Cidofovir; D003556:Cystitis / Q000188:drug therapy / Q000821:virology; D003596:Cytosine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004334:Drug Administration Schedule; D018380:Hematopoietic Stem Cell Transplantation; D006470:Hemorrhage / Q000188:drug therapy / Q000821:virology; D006801:Humans; D063065:Organophosphonates / Q000008:administration & dosage*; D027601:Polyomavirus Infections / Q000188:drug therapy* / Q000821:virology; D011339:Probenecid / Q000008:administration & dosage; D014412:Tumor Virus Infections / Q000188:drug therapy* / Q000821:virology
D000998:Antiviral Agents; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir; D011339:Probenecid