Interaction between curcumin and opioid system in the formalin test of rats.
In this study, the effect of curcumin on the formalin-induced pain was investigated in rats. Interaction between curcumin and opioid system using morphine and naloxone was also examined. A biphasic pain response was induced after intraplantar injection of formalin (50 microL, 1%). Curcumin, morphin and naloxone had no effect on the early phase of pain. Late phase of pain was suppressed by curcumin at the doses of 100 and 200 mg kg(-1) body weigh. Morphine (1 mg kg(-1) BW) reduced, whereas naloxone (1 mg kg(-1) BW) did not affect the late phase of pain. Currcumin did not influence the morphine-induced antinociception, but reversed the effect of naloxone on pain. Present findings indicate that curcumin may produce antinociception by activation of both opioid and non opioid mechanisms of pain.
Tajik
Hossein
H
Department of Food Hygiene, College of Veterinary Medicine, Urmia University, Urmia, Iran.
Tamaddonfard
Esmaeal
E
Hamzeh-Gooshchi
Nasrin
N
D000701:Analgesics, Opioid / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism*; D003474:Curcumin / Q000378:metabolism*; D008297:Male; D009020:Morphine / Q000378:metabolism; D009270:Naloxone / Q000378:metabolism; D010146:Pain / Q000503:physiopathology*; D010147:Pain Measurement; D051381:Rats; D017208:Rats, Wistar; D011957:Receptors, Opioid / Q000378:metabolism*
D000701:Analgesics, Opioid; D000970:Antineoplastic Agents; D011957:Receptors, Opioid; D009270:Naloxone; D009020:Morphine; D003474:Curcumin