Adenocarcinoma following ileal pouch-anal anastomosis for ulcerative colitis: review of 26 cases.
The occurrence of adenocarcinoma following ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC) is an infrequent and but potentially lethal complication. We have seen 1 such case among 520 IPAAs performed in our group practice between 1978 and February 2008. We have added this case to a review of 25 previously reported cases of adenocarcinoma of the pouch or outflow tract following IPAA for UC. Our conclusions are 1) that post-IPAA cancer can occur following either mucosectomy or stapled anastomosis; 2) that this malignancy can occur after IPAA performed for UC either with or without neoplasia; and 3) that this complication is seen whether or not the initial cancer or dysplasia had involved the rectum.
Branco
Bernardino C
BC
Department of General Surgery, Mount Sinai School of Medicine, New York, New York 10029, USA.
Sachar
David B
DB
Heimann
Tomas M
TM
Sarpel
Umut
U
Harpaz
Noam
N
Greenstein
Adrian J
AJ
D000230:Adenocarcinoma / Q000150:complications*; D000328:Adult; D000368:Aged; D000714:Anastomosis, Surgical / Q000009:adverse effects; D003093:Colitis, Ulcerative / Q000601:surgery*; D039021:Colonic Pouches / Q000009:adverse effects; D005260:Female; D006801:Humans; D007414:Intestinal Neoplasms / Q000150:complications*; D008297:Male; D008875:Middle Aged; D016737:Proctocolectomy, Restorative / Q000009:adverse effects*