Anti-obesity and antidiabetic effects of deep sea water on ob/ob mice.
Recently, deep sea water (DSW) has started to receive much attention for therapeutic intervention in some lifestyle diseases. In this study, the anti-obesity and antidiabetic effects of DSW in ob/ob mice were investigated. The animals were randomly divided into two groups with six animals: control group received tap water; the experimental group was treated with DSW of hardness 1000 for 84 days. The body weight gain after 84 days in DSW-fed group was decreased by 7% compared to the control group. The plasma glucose levels in the DSW-fed mice were substantially reduced by 35.4%, as compared to control mice. The results of oral glucose tolerance test revealed that DSW-fed groups significantly increased the glucose disposal after 84 days. DSW increased plasma protein levels of adiponectin and decreased plasma protein levels of resistin, RBP4, and fatty acid binding protein. Moreover, GLUT4 and AMP-activated protein kinase levels in skeletal muscle tissue were increased while peroxisome proliferator-activated receptor gamma and adiponectin were decreased in adipose tissue of DSW-fed mice. These results suggest that the antidiabetic and anti-obesity activities of DSW were mediated by modulating the expression of diabetes- and obesity-specific molecules. Taken together, these results provide a possibility that continuous intake of DSW can ameliorate obesity and diabetes.
Hwang
Hee Sun
HS
Department of Biotechnology, Daegu University, Kyungsan, Kyungbuk, South Korea.
Kim
Hyun Ah
HA
Lee
Sung Hak
SH
Yun
Jong Won
JW
D052242:Adiponectin / Q000378:metabolism; D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005618:Fresh Water; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D008297:Male; D051379:Mice; D008820:Mice, Obese; D047495:PPAR gamma / Q000378:metabolism; D052243:Resistin / Q000378:metabolism; D012623:Seawater; D015431:Weight Loss / Q000187:drug effects
D052242:Adiponectin; C499919:Adipoq protein, mouse; D019440:Anti-Obesity Agents; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D008055:Lipids; D047495:PPAR gamma; D052243:Resistin; C499623:Retn protein, mouse