title: Recent trends in antimicrobial susceptibility and the presence of the tetracycline resistance gene in Actinobacillus pleuropneumoniae isolates in Japan.
abstract: A total of 101 Actinobacillus pleuropneumoniae isolates from diseased pigs taken from across Japan during 2002 to 2005 were examined for antimicrobial susceptibility. All isolates were susceptible to ceftiofur, erythromycin, florfenicol and enrofloxacin. Antimicrobial-resistant isolates to oxytetracycline (OTC) (27.7%), dihydrostreptomycin (10.9%), thiamphenicol (10.9%), kanamycin (5.9%), trimethoprim (4.0%) and ampicillin (2.0%) were recognized. OTC-resistant isolates taken from 1986 to 2005 were examined for the tetracycline resistance gene. In OTC-resistant isolates, tetB has been the most frequently isolated gene in Japan. It is likely that the dissemination of tetB has contributed to the increased OTC resistance of A. pleuropneumoniae in Japan.
authors.affiliation: National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, Tokyo, Japan. morioka@nval.go.jp
authors.forename: Ayako
authors.initials: A
authors.lastname: Morioka
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Asai
authors.forename: Hayato
authors.initials: H
authors.lastname: Nitta
authors.forename: Kinya
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Ogikubo
authors.forename: Toshio
authors.initials: T
authors.lastname: Takahashi
authors.forename: Shoko
authors.initials: S
authors.lastname: Suzuki
mesh_terms: D000189:Actinobacillus Infections / Q000188:drug therapy / Q000662:veterinary*; D016977:Actinobacillus pleuropneumoniae / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D007564:Japan; D008826:Microbial Sensitivity Tests; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy / Q000382:microbiology*; D013752:Tetracycline / Q000494:pharmacology; D013753:Tetracycline Resistance / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D013752:Tetracycline