Management of complications from estrogen deprivation in breast cancer patients.
In the United States today, more than 2 million women live as breast cancer survivors. As the number of cancer survivors grows, the unique long-term side effects of cancer treatment and aging play an increasingly prominent role in the routine care of these patients. Of special concern are the short- and long-term effects of sex hormone deprivation. This article reviews current issues surrounding the acute and late effects associated with hormone deprivation in breast cancer survivors and summarizes the scientific and therapeutic discoveries to date to identify optimal nonestrogenic treatments for symptom control in individual patients.
Hershman
Dawn L
DL
Department of Medicine and Epidemiology, College of Physicians and Surgeons and the Mailman School of Public Health, New York Presbyterian Hospital, Columbia University Medical Center, New York, NY 10032, USA. dlh23@columbia.edu
Cho
Christina
C
Crew
Katherine D
KD
D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D017024:Chemotherapy, Adjuvant / Q000379:methods; D002986:Clinical Trials as Topic; D004965:Estrogen Antagonists / Q000009:adverse effects*; D004967:Estrogens / Q000378:metabolism*; D015444:Exercise; D005260:Female; D006801:Humans; D008495:Medical Oncology / Q000379:methods; D011788:Quality of Life; D012107:Research Design; D013739:Testosterone / Q000494:pharmacology; D016896:Treatment Outcome; D015430:Weight Gain
D004965:Estrogen Antagonists; D004967:Estrogens; D013739:Testosterone