Involvement of anoikis-resistance in the metastasis of hepatoma cells.
Acquisition of anoikis-resistance is a pre-requisite for cancer cell metastasis. We have demonstrated that hepatoma cells could resist anoikis by a synoikis-like survival style. In this study, we further suggest that acquisition of anoikis-resistance confer cancer cells more capacity for invasiveness, evading from cancer therapeutic agents and escaping from host immune attacks. We investigated the response of anoikis-resistant hepatoma cells to TNF-related apoptosis-inducing ligand (TRAIL), a typical immune surveillant molecule as well as a potential anticancer agent. Our data indicated that detached hepatoma cells not only resist TRAIL-induced apoptosis, but also domesticate TRAIL to exert a stealth "tumor counterattack" effect. These results reveal that acquisition of anoikis-resistance may act as a selective pressure to superimpose on hepatoma cells more metastatic potential for the development of cancer.
Cao
Lili
L
Department of Immunology, School of Medicine, Shandong University, Jinan 250012, China.
Han
Lihui
L
Zhang
Zhiyong
Z
Li
Jie
J
Qu
Zhonghua
Z
Du
Juan
J
Liang
Xiaohong
X
Liu
Yugang
Y
Liu
Hua
H
Shi
Yongyu
Y
Liu
Suxia
S
Gao
Lifen
L
Sun
Wensheng
W
D023102:Anoikis / Q000502:physiology*; D006528:Carcinoma, Hepatocellular / Q000473:pathology* / Q000503:physiopathology; D020169:Caspases / Q000378:metabolism; D002448:Cell Adhesion; D045744:Cell Line, Tumor; D004789:Enzyme Activation; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology* / Q000503:physiopathology; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis / Q000473:pathology*; D020411:Oligonucleotide Array Sequence Analysis; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000235:genetics / Q000378:metabolism*
D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; D053221:TNF-Related Apoptosis-Inducing Ligand; D020169:Caspases