[Paraoxonase: biological activity and clinical implications].
The involvement of paraoxonase family in antiathrogenesis has recently attracted attention of many researchers to these enzymes. Type 1 paraoxonase (PON 1) is a Ca-dependent hydrolase with a broad spectrum of substrate specificity. It is tightly bound to plasma high density lipoproteins (HDLP) and exhibits antioxidative and antiatherogenic activities. This review analyses publications concerning the structure, biological activity, and clinical significance ofparaoxonases, in the first place PON 1. Consideration of genetic and regulatory aspects of PON 1 is important for better understanding clinical and prognostic implications of this enzyme. These data are supplemented by the results of original observations of 60 patients with systemic lupus erythematosus and 20 with rheumatoid arthritis admitted to the Institute of Rheumatology. They confirm the published reports indicating reduced activity of this enzyme in patients compared with healthy donors.
Voronin
M V
MV
Lisitsyna
T A
TA
Durnev
A D
AD
Nasonov
E L
EL
D000818:Animals; D001168:Arthritis / Q000201:enzymology*; D043303:Aryldialkylphosphatase / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D018450:Disease Progression; D006801:Humans
D015415:Biomarkers; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human