title: [Quantitative approach for calculation of pharmacodynamic interactions and simulation of combined response].
abstract: OBJECTIVE
  An approach is set up to calculate pharmacodynamic interaction and simulate the combined response.
  
  
  METHODS
  An orthogonal design with 1-level = high dose and 2-level = low dose was adopted. An example of the compound with four components was applied to evaluate this quantitative approach. The bias was evaluated by the both scatter plots.
  
  
  RESULTS
  This approach can calculate the value of each component with different dose by its contribution to combined response, and the value is related to the importance of a compound. Drug interactions were evaluated among the combinations in each group. The prediction model performed well and simulated the combined response in the different of components in combination.
  
  
  CONCLUSIONS
  The approach can be used in the similar research, and it also provides predictions of component combinations from the other studies by simulation.
authors.affiliation: Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Jun-chao
authors.initials: JC
authors.lastname: Chen
authors.forename: You-jun
authors.initials: YJ
authors.lastname: Pan
authors.forename: Xing-shan
authors.initials: XS
authors.lastname: Li
authors.forename: Jie
authors.initials: J
authors.lastname: Sun
authors.forename: Hong-xia
authors.initials: HX
authors.lastname: Liu
authors.forename: Rui-yuan
authors.initials: RY
authors.lastname: Sun
authors.forename: Qing-shan
authors.initials: QS
authors.lastname: Zheng
mesh_terms: D000818:Animals; D003198:Computer Simulation; D004347:Drug Interactions; D010600:Pharmacology / Q000379:methods*; D051381:Rats