[Autoantibodies to steroid-producing ovarian cells in cancer patients].
Our investigation included 158 women, aged 23-73: patients with tumors of the ovary, breast and endometrium--117 and subjects without oncological pathology--41. Autoantibodies to microsomal fraction of follicular ovarian cells (> 500 Unit/ml) in healthy subjects were revealed 8.3% while in patients with ovarian, breast and endometrial malignancies (without significant differences between benign and malignant tumors) in 33.30%, 45.60% and 25.0%, respectively. Higher level of anti-ovarian autoantibodies involved an inverse correlation between blood levels of FSH and estradiol in ovarian and endometrial carcinoma patients. It also co-occurred with a tendency of increasing levels of autoantibodies to thyroglobulin. Whatever apparent predictive accuracy in oncological clinic, high concentrations of anti-ovarian autoantibodies point to certain shifts taking place in the formation of reproductive system pathology. Besides, they may have considerable prognostic significance.
Bershteĭn
L M
LM
Poroshina
T E
TE
Vasil'ev
D A
DA
Orlova
A V
AV
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000276:immunology*; D016889:Endometrial Neoplasms / Q000276:immunology*; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D012739:Gonadal Steroid Hormones / Q000096:biosynthesis*; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000276:immunology*; D010053:Ovary / Q000276:immunology* / Q000378:metabolism; D011237:Predictive Value of Tests; D011379:Prognosis; D013954:Thyroglobulin / Q000276:immunology; D055815:Young Adult
D001323:Autoantibodies; D014408:Biomarkers, Tumor; D012739:Gonadal Steroid Hormones; D004958:Estradiol; D005640:Follicle Stimulating Hormone; D013954:Thyroglobulin