Degree of gingivitis correlates to systemic inflammation parameters.
BACKGROUND
Investigation of interrelations between periodontal and systemic inflammatory parameters in periodontal health.


METHODS
40 periodontally healthy (probing pocket depths [PPD]<3.6 mm and from 3.6 mm to 4 mm without bleeding on probing [BOP]; up to 2 sites with a PPD from 3.6 mm to 5 mm and BOP or up to 4 sites with a PPD from 3.6 mm to 5 mm without BOP were accepted; BOP<or=14%) probands 23 to 44 years of age without any known actual infectious or inflammatory diseases were examined. Clinical parameters and blood samples were obtained. The blood was analyzed for C-reactive protein (CRP), elastase, and leukocyte counts. Regression models were calculated to explain the variation of the dependent variables serum CRP, elastase, and leukocytes (independent variables: sex, age, PCR, BOP, smoking, PPD).


RESULTS
The sample was characterized as: GBI: 2.9+/-2.0%; PCR: 14.9+/-8.2%; PPD: 2.0+/-0.2 mm; AL: 0.4+/-0.3 mm; BOP: 7.0+/-1.9%; leukocytes: 6.2+/-1.1/nl; (median/interquartile range) CRP: 0.062/0.04-0.107) mg/dl; elastase: 9.075/7.375-12.2 ng/ml. Inflammatory parameters were influenced by the following factors: CRP: female (p=0.008), PPD (p=0.15); elastase: female (p=0.002), PPD (p=0.005), BOP (p=0.141); leukocytes: female (p=0.061), pack years (p=0.061), PCR (p=0.082).


CONCLUSIONS
The levels of all investigated systemic inflammation parameters were higher in females than in males. Both serum CRP and elastase correlated even in periodontally healthy with mean PPD.
Wohlfeil
Martin
M
Department of Periodontology, Center for Dental, Oral, and Maxillofacial Medicine (Carolinum), Hospital of the Johann Wolfgang Goethe-University Frankfurt/Main, Theodor-Stern-Kai 7, Frankfurt, Germany.
Wehner
Jasmin
J
Schacher
Beate
B
Oremek
Gerhard M
GM
Sauer-Eppel
Hildegund
H
Eickholz
Peter
P
D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis*; D005260:Female; D005891:Gingivitis / Q000097:blood / Q000473:pathology*; D006801:Humans; D007249:Inflammation / Q000097:blood*; D007958:Leukocyte Count; D008297:Male; D010196:Pancreatic Elastase / Q000097:blood*; D012044:Regression Analysis
D002097:C-Reactive Protein; D010196:Pancreatic Elastase