Developmental patterning by mechanical signals in Arabidopsis.
A central question in developmental biology is whether and how mechanical forces serve as cues for cellular behavior and thereby regulate morphogenesis. We found that morphogenesis at the Arabidopsis shoot apex depends on the microtubule cytoskeleton, which in turn is regulated by mechanical stress. A combination of experiments and modeling shows that a feedback loop encompassing tissue morphology, stress patterns, and microtubule-mediated cellular properties is sufficient to account for the coordinated patterns of microtubule arrays observed in epidermal cells, as well as for patterns of apical morphogenesis.
Hamant
Olivier
O
INRA, Laboratoire de Reproduction et Développement des Plantes, 46 Allée d'Italie, 69364 Lyon Cedex 07, France.
Heisler
Marcus G
MG
Jönsson
Henrik
H
Krupinski
Pawel
P
Uyttewaal
Magalie
M
Bokov
Plamen
P
Corson
Francis
F
Sahlin
Patrik
P
Boudaoud
Arezki
A
Meyerowitz
Elliot M
EM
Couder
Yves
Y
Traas
Jan
J
D017360:Arabidopsis / Q000033:anatomy & histology / Q000166:cytology / Q000254:growth & development*; D048430:Cell Shape; D002473:Cell Wall / Q000502:physiology / Q000648:ultrastructure; D002482:Cellulose; D004136:Dinitrobenzenes / Q000494:pharmacology; D018519:Meristem / Q000166:cytology / Q000254:growth & development*; D020894:Microfibrils / Q000502:physiology; D008870:Microtubules / Q000502:physiology* / Q000648:ultrastructure; D008954:Models, Biological; D009024:Morphogenesis; D019441:Plant Epidermis / Q000502:physiology; D018520:Plant Shoots / Q000033:anatomy & histology / Q000166:cytology / Q000254:growth & development*; D018547:Plant Stems / Q000166:cytology / Q000254:growth & development; D011312:Pressure; D013314:Stress, Mechanical; D013424:Sulfanilamides / Q000494:pharmacology; D050257:Tubulin Modulators / Q000494:pharmacology
D004136:Dinitrobenzenes; D013424:Sulfanilamides; D050257:Tubulin Modulators; C012465:oryzalin; D002482:Cellulose