Efficient and divergent synthesis of cyclophosphamide analogues from 2-arylamino-3-acetyl-5,6-dihydro-4H-pyrans.
A facile and efficient one-pot synthesis of substituted cyclophosphamidic chlorides and their analogues has been developed from readily available enaminones, 2-arylamino-3-acetyl-5,6-dihydro-4H-pyrans.
Xiang
Dexuan
D
Department of Chemistry, Northeast Normal University, 130024, Changchun, China.
Huang
Peng
P
Wang
Kewei
K
Zhou
Guangyuan
G
Liang
Yongjiu
Y
Dong
Dewen
D
D000107:Acetylation; D000588:Amines / Q000737:chemistry*; D003520:Cyclophosphamide / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D011714:Pyrans / Q000737:chemistry*
D000588:Amines; D011714:Pyrans; C030011:carbene; D006859:Hydrogen; D003520:Cyclophosphamide; D008697:Methane