title: Temporal coupling of rapid eye movements and cerebral activities during REM sleep.
abstract: OBJECTIVE
  We investigated event-related potentials time locked to the onset and offset of rapid eye movements during rapid eye movement (REM) sleep.
  
  
  METHODS
  Nine healthy university students participated in this study. Data were collected in a sleep laboratory. Rapid eye movements during REM sleep were recorded during natural nocturnal sleep. Saccades during wakefulness were recorded during a visually triggered task. Event-related potentials were averaged, time-locked to the onset and offset of eye movements.
  
  
  RESULTS
  During REM sleep, a lambda-like response occurred over the occipital region, time-locked to the offset of rapid eye movements (similar to what occurs during wakefulness). Moreover, we found that a positive potential (P200r) occurred at about 200ms, with the maximal amplitude over the central region and time-locked to the onset of rapid eye movements during REM sleep; this potential was not observed during wakefulness.
  
  
  CONCLUSIONS
  During REM sleep, the P200r occurs with the start of rapid eye movements, and then the lambda-like response occurs after termination of the movements.
  
  
  CONCLUSIONS
  We demonstrated temporal coupling of rapid eye movements and cerebral activities during REM sleep. These activities might provide a useful basis for future investigations of brain functions during REM sleep.
authors.affiliation: Faculty of Sport Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa, Saitama, 359-1192, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Ogawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Abe
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nittono
authors.forename: Katuo
authors.initials: K
authors.lastname: Yamazaki
authors.forename: Tadao
authors.initials: T
authors.lastname: Hori
mesh_terms: D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology*; D004569:Electroencephalography; D004585:Electrooculography / Q000379:methods; D005071:Evoked Potentials / Q000502:physiology; D005133:Eye Movements / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D017286:Polysomnography / Q000379:methods; D011930:Reaction Time / Q000502:physiology; D012895:Sleep, REM / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology; D055815:Young Adult