title: [A case of familial Crohn's disease observed in a parent and his offspring].
abstract: Crohn's disease (CD), one of the major forms of idiopathic inflammatory bowel disease (IBD), is thought to be related to genetic susceptibility coupled with environmental factors. A positive family history is the strongest risk factor for the development of CD. The 10-fold increase in the familial risk of CD strongly suggests that these disorders have a genetic background. The prevalence of IBD in Asian populations is lower than in Western populations, which may be due to genetic influences, environmental factors, or a combination of both. In a Korean study, only 0.25% of parents had IBD in CD probands and all of them had ulcerative colitis. The term of familial CD was used only for those with one or more first-degree relatives with confirmed CD. There are few case reports about familial Crohn's disease in Korea. We report a case of familial CD that the father, the first degree relative was diagnosed as small bowel CD after confirming his son as having CD.
authors.affiliation: Departments of Internal Medicine, Hanyang University College of Medicine, Guri, Korea.
authors.forename: Hyun Seok
authors.initials: HS
authors.lastname: Cho
authors.forename: Tae Jun
authors.initials: TJ
authors.lastname: Byun
authors.forename: Sang Bong
authors.initials: SB
authors.lastname: Ahn
authors.forename: Tae Yeob
authors.initials: TY
authors.lastname: Kim
authors.forename: Chang Soo
authors.initials: CS
authors.lastname: Eun
authors.forename: Yong Cheol
authors.initials: YC
authors.lastname: Jeon
authors.forename: Yong Seok
authors.initials: YS
authors.lastname: Kim
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Han
mesh_terms: D002648:Child; D003113:Colonoscopy; D003424:Crohn Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D005190:Family; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011859:Radiography