title: Microwave-assisted one step synthesis of 8-arylmethyl-9H-purin-6-amines.
abstract: Molecular chaperone heat shock protein 90 (Hsp90) is an important target in cancer and neurodegenerative diseases, and has rapidly become the focus of several drug discovery efforts. Among small molecule Hsp90 inhibitors with clinical applicability are derivatives of 8-arylmethyl-9H-purin-6-amine class. Here we report the use of microwave-assisted chemistry for the successful one-pot delivery of 8-arylmethyl-9H-purin-6-amines. We discuss the applicability as well as the limitations of this method towards the creation of a large chemical diversity in the 8-arylmethyl-9H-purin-6-amine series.
authors.affiliation: Program in Molecular Pharmacology and Chemistry and Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 482, New York, NY 10021, USA.
authors.forename: Hui
authors.initials: H
authors.lastname: Tao
authors.forename: Yanlong
authors.initials: Y
authors.lastname: Kang
authors.forename: Tony
authors.initials: T
authors.lastname: Taldone
authors.forename: Gabriela
authors.initials: G
authors.lastname: Chiosis
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D055808:Drug Discovery; D008872:Microwaves; D011687:Purines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000588:Amines; D011687:Purines