title: Long-term effect of gluten-free diet on growth velocity in Turkish children with celiac disease.
abstract: We sought to analyze the long-term growth in children with celiac disease (CD) as well as the association of height and weight SD score at the end of 4 years with the demographic and clinical presentation at initial admission. Thirty-four children with CD were enrolled in the study and followed for at least 4 years. Patients were divided into three groups (Group 1: patients <or=5 years old, Group 2: patients 5-10 years old, and Group 3: patients >10 years, at the time of diagnosis). Patients' charts were reviewed for demographic and clinical features at initial admission. Anthropometric measurements at initial admission, at 6th months, and 1st, 2nd, 3rd, and 4th years were recorded. Gluten-free diet led to rapid increase in weight SD and height SD score in patients <or=5 years old at the time of diagnosis (Group 1). Increment in height SD score was the highest in patients 5-10 years old (Group 2) at the end of 4 years. A negative correlation was found between age at the time of diagnosis and weight and height SD score at the end of 4 years (r = -0.503, P = 0.03 and r = -0.554, P = 0.01). Multiple regression analysis revealed that height SD score at the end of the 4 years was associated with age at the time of diagnosis. The other factors had no effect on the weight and height SD score at the end of 4 years. Early diagnosis and good adhesion to a gluten-free diet are essential for long-term growth in CD. Celiac societies and the mass media must expand an effort to educate the community regarding the symptoms of the disease.
authors.affiliation: Department of Pediatric Gastroenterology Hepatology and Nutrition, Ege University, Bornova, Izmir, Turkey.
authors.forename: Sema
authors.initials: S
authors.lastname: Aydogdu
authors.forename: Levent
authors.initials: L
authors.lastname: Midyat
authors.forename: Murat
authors.initials: M
authors.lastname: Cakir
authors.forename: Gokhan
authors.initials: G
authors.lastname: Tumgor
authors.forename: Hasan Ali
authors.initials: HA
authors.lastname: Yuksekkaya
authors.forename: Masallah
authors.initials: M
authors.lastname: Baran
authors.forename: Cigdem
authors.initials: C
authors.lastname: Arikan
authors.forename: Funda
authors.initials: F
authors.lastname: Ozgenc
authors.forename: Rasit Vural
authors.initials: RV
authors.lastname: Yagci
mesh_terms: D000293:Adolescent; D001827:Body Height; D001835:Body Weight; D002446:Celiac Disease / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D055050:Diet, Gluten-Free; D005260:Female; D006128:Growth / Q000502:physiology*; D006801:Humans; D008297:Male; D014421:Turkey