Drug-associated linear IgA disease mimicking toxic epidermal necrolysis.
Linear IgA disease (LAD) is an uncommon, acquired, autoimmune blistering disorder with a characteristic linear IgA deposition along the basement membrane zone. LAD can be idiopathic or drug-induced. Drug-related LAD most commonly occurs after exposure to vancomycin, but phenytoin and other medications have been implicated. A small number of cases of drug-induced LAD clinically resembling TEN have been reported. We report a case of phenytoin-associated LAD clinically mimicking TEN in a 57-year-old woman. This case shows the necessity of investigating TEN patients for autoimmune bullous diseases, using immunofluorescence studies.
Khan
I
I
Departments of Dermatology, University Hospital Galway, Ireland. drimranuk@hotmail.com
Hughes
R
R
Curran
S
S
Marren
P
P
D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000927:Anticonvulsants / Q000009:adverse effects*; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D008875:Middle Aged; D010672:Phenytoin / Q000008:administration & dosage / Q000009:adverse effects*; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000473:pathology; D013262:Stevens-Johnson Syndrome / Q000209:etiology* / Q000473:pathology; D014640:Vancomycin / Q000008:administration & dosage
D000900:Anti-Bacterial Agents; D000927:Anticonvulsants; D007070:Immunoglobulin A; D010672:Phenytoin; D014640:Vancomycin