[Analgesic effect of corticotropin releasing factor (CRF) on somatic pain sensitivity: participation of glucocorticoid and CRF-2 receptors].
The aim of this study was to investigate the participation of glucocorticoid receptors and corticotropin releasing factor receptors of subtype 2 (CRF-2 receptors) in the analgesic effect of CRF on somatic pain sensitivity. The participation of glucocorticoid receptors and CRF-2 receptors in the CRF-induced analgesia was investigated by the receptors antagonists: RU38486 or astressin 2-B, respectively, in anaesthetized rats. For estimation of pain sensitivity the threshold of pain reaction induced by electrical stimulation of the rat' tail as tested before and during 30 min after the systemic injection of CRF. The CRF-induced analgesic effect was partly abolished by glucocorticoid receptor antagonist RU 38486 and completely abolished by CRF-2 receptor antagonist astressin 2-B. The data suggest that glucocorticoid receptors and CRF-2 receptors participate in the CRF-induced analgesic effect.
Iarushkina
N I
NI
Bagaeva
T R
TR
Filaretova
L P
LP
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology*; D006727:Hormone Antagonists / Q000494:pharmacology; D008297:Male; D015735:Mifepristone / Q000494:pharmacology; D010146:Pain / Q000188:drug therapy / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018019:Receptors, Corticotropin-Releasing Hormone / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011965:Receptors, Glucocorticoid / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013997:Time Factors
D000700:Analgesics; C101531:CRF receptor type 2; D006727:Hormone Antagonists; D018019:Receptors, Corticotropin-Releasing Hormone; D011965:Receptors, Glucocorticoid; D015735:Mifepristone; D003346:Corticotropin-Releasing Hormone