Virilization persists in a woman with an androgen-secreting granulosa cell tumor.
OBJECTIVE
To report a case of a woman who presented with amenorrhea and masculinization secondary to an androgen-secreting granulosa cell (GC) tumor, with refractory masculinization.


METHODS
Case report.


METHODS
University medical center.


METHODS
A 45-year-old woman with abrupt onset of virilization with high serum androgen levels.


METHODS
Exploratory laparotomy with full staging.


METHODS
Surgical findings and histopathologic observations are included in this report.


RESULTS
Pathologic examination revealed an inhibin stain positive GC tumor of the adult type. Virilization has persisted for 8 years after surgery.


CONCLUSIONS
Adult-type GC tumor is an extremely rare cause of virilization. Masculinization features may persist in the absence of high androgen levels.
Patel
Satin S
SS
Departments of Obstetrics & Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9032, USA.
Carrick
Kelley S
KS
Carr
Bruce R
BR
D000568:Amenorrhea / Q000209:etiology / Q000378:metabolism; D000728:Androgens / Q000097:blood*; D001062:Appendectomy; D005260:Female; D006106:Granulosa Cell Tumor / Q000150:complications* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D006801:Humans; D007044:Hysterectomy; D007265:Inhibins / Q000378:metabolism; D008197:Lymph Node Excision; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D010052:Ovariectomy; D016896:Treatment Outcome; D014770:Virilism / Q000209:etiology* / Q000378:metabolism
D000728:Androgens; D007265:Inhibins