title: Some clinico and histopathological changes in female goats experimentally exposed to dioxin.
abstract: Female Baladi goats were used for investigating the toxicological effects of dioxin. Each animal in the treated group was given an oral dose of 4 mL of stock standard solution of dioxin (labelled and native congeners) diluted in 5 mL distilled water (1/3 of LD50) for three times with 2 days interval and slaughtered 16 days post treatment. Blood and tissue samples were taken and subjected for haemogram, biochemical and pathological studies as well as for determination of dioxin residues. Results revealed that exposure of female goats to dioxin induced anemia, leucocytopenia, neutropenia and eosinophilia with non significant increases in activities of serum ALT and AST as compared with untreated group. Meanwhile, activity of ALP and BUN concentration were significantly increased. Histopathological examination showed degenerative and necrotic changes associated with inflammatory reaction in liver and kidney, in addition to cystic glandular hyperplasia and adenomyosis in uterus. In ovarian tissue, marked decrease ofpreantral follicles together with cystic atretic follicle were noticed. The average percentage residues ofpg WHO-TEQ values for dioxins (PCDDs and PCDFs) in liver, kidney, mammary gland, uterus and milk after oral dose were 0.013, 0.0012, 0.0012, 0.009 and 0.0012%, respectively. It was concluded that oral exposure to dioxin in female goats induced adverse effects on liver and kidney. Dioxins had estrogenic like effect as indicated by uterine and ovarian histopathological changes.
authors.affiliation: Food Toxicology and Contaminants, National Research Centre, Giza, Egypt.
authors.forename: A S M
authors.initials: AS
authors.lastname: Fouzy
authors.forename: H M
authors.initials: HM
authors.lastname: Desouky
authors.forename: Y A
authors.initials: YA
authors.lastname: Ghazi
authors.forename: A M
authors.initials: AM
authors.lastname: Hammam
mesh_terms: D000284:Administration, Oral; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004147:Dioxins / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D006041:Goats / Q000502:physiology*; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008321:Mammary Glands, Animal / Q000187:drug effects / Q000473:pathology; D009336:Necrosis; D010053:Ovary / Q000187:drug effects / Q000473:pathology; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives / Q000032:analysis; D012997:Solvents; D014599:Uterus / Q000187:drug effects / Q000473:pathology
chemical_list: D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins; D012997:Solvents; D003404:Creatinine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase