title: [Evaluation of the prenatal screening mode for fetal congenital heart diseases by ultrasound].
abstract: OBJECTIVE
  To assess prenatal heart disease screening program by ultrasound.
  
  
  METHODS
  A total of 11,544 second-trimester screening scans were performed before 24 weeks' gestation on 11,410 women between February 2004 and May 2007 in Obstetrics and Gynecology Hospital of Fudan University. Fetal heart screening was based on four-chamber and outflow tract views (left ventricular outflow + three vessel view). The sensitivity and specificity of different views were evaluated. Follow-up data of newborns was obtained.
  
  
  RESULTS
  (1) Among 11,544 cases,48 cases of congenital heart disease (CHD) were diagnosed in utero. Six cases were false negative, and 2 cases were false positive. The incidence of CHD was 0.47% (54/11 544). (2) Thirty-three CHDs were detected based on the four-chamber view, including 18 ventricular septal defect (9 with conotruncal anomalies), 6 anomalous atrioventricle valve, 9 disproportion of left/right ventricle. The sensitivity of the four-chamber view alone was 61.11% (33/54), and the specificity was 99.98% (11 488/11 490). Fifteen CHDs were detected based on the left ventricular outflow and three vessel views, including 1 pulmonary atresia, 3 pulmonary valve stenosis, 2 transposition of the great arteries (TGA), 1 pulmonary stenosis with TGA, 6 tetralogy of Fallot, and 2 pulmonary stenosis. The sensitivity of the combination of the four-chamber and outflow tract views was 88.89% (48/54), and the specificity was 99.98% (11 488/11 490). (3) Of 48 CHDs, 11 cases were accompanied by other malformations. Eleven cases were performed amniocentesis, among whom 5 cases were trisomy 21.
  
  
  CONCLUSIONS
  The screening program based on four-chamber and outflow tract views shows good sensitivity and excellent specificity. Our prenatal heart screening program is clinically feasible.
authors.affiliation: Department of Prenatal Diagnosis Center, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China.
authors.forename: Yun-Yun
authors.initials: YY
authors.lastname: Ren
authors.forename: Xiao-Tian
authors.initials: XT
authors.lastname: Li
authors.forename: Yong-Hao
authors.initials: YH
authors.lastname: Gui
authors.forename: Ying-Liu
authors.initials: YL
authors.lastname: Yan
authors.forename: Cai
authors.initials: C
authors.lastname: Chang
authors.forename: Jue-Hua
authors.initials: JH
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Sun
authors.forename: Yu-Qing
authors.initials: YQ
authors.lastname: Zhou
authors.forename: Fan-Bin
authors.initials: FB
authors.lastname: Kong
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000649:Amniocentesis; D004314:Down Syndrome / Q000000981:diagnostic imaging; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000517:prevention & control; D005318:Fetal Heart / Q000002:abnormalities / Q000000981:diagnostic imaging*; D005865:Gestational Age; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000517:prevention & control; D006345:Heart Septal Defects, Ventricular / Q000000981:diagnostic imaging / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D008403:Mass Screening; D011237:Predictive Value of Tests; D011247:Pregnancy; D012680:Sensitivity and Specificity; D016216:Ultrasonography, Prenatal / Q000379:methods*; D055815:Young Adult