Discovery of a novel molecule that regulates tumor growth and metastasis.
The heparan sulfate proteoglycan, Glypican-1 (GPC1), significantly impacts the growth of pancreatic cancer cells in vivo and markedly attenuates tumor angiogenesis and metastasis in athymic mice. Interestingly, both cancer cell-derived and host-derived GPC1 play an important role in tumor development and spread. These data suggest that GPC1 may be a valid therapeutic target for pancreatic cancer.
Whipple
Chery A
CA
Department of Medicine, Dartmouth Hitchcock Medical Center and Dartmouth Medical School, Hanover, NH, USA. Chery.A.Whipple@Dartmouth.edu
Lander
Arthur D
AD
Korc
Murray
M
D000818:Animals; D049109:Cell Proliferation; D018450:Disease Progression; D053673:Glypicans / Q000235:genetics / Q000378:metabolism; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D015398:Signal Transduction
D053673:Glypicans