Pharmacokinetics and dialysate levels of daptomycin given intravenously in a peritoneal dialysis patient.
In this report we present pharmacokinetic (Pk) data of daptomycin given intravenously in a peritoneal dialysis patient. Daptomycin plasma levels were within therapeutic range; however, half-life of the drug was prolonged compared to haemodialysis. Both plasma and dialysate levels were found to be consistently above the minimal inhibitory concentration for daptomycin sensitive strains.
Goedecke
Vega A
VA
Department of Internal Medicine, Division of Nephrology and Hypertension.
Clajus
Christian
C
Burkhardt
Olaf
O
Martens-Lobenhoffer
Jens
J
Bode-Boger
Stefanie M
SM
Kielstein
Jan T
JT
Hiss
Marcus
M
D019540:Area Under Curve; D017576:Daptomycin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D015314:Dialysis Solutions / Q000032:analysis*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010530:Peritoneal Dialysis
D015314:Dialysis Solutions; D017576:Daptomycin