Mesalamine hypersensitivity and Kounis syndrome in a pediatric ulcerative colitis patient.
5-aminosalicylic acid (mesalamine) rarely induces hypersensitivity reactions. If chest pain associated with atypical electrocardiographic changes are seen during its administration, one should always bear in mind type I variant of Kounis syndrome. This variant includes patients, of any age, with normal coronary arteries, without predisposing factors for coronary artery disease, in whom the acute release of inflammatory mediators from mast cells can induce either sudden coronary artery narrowing, without increase of cardiac enzymes and troponins, or coronary artery spasm that progresses to acute myocardial infarction, with elevated cardiac enzymes and troponins.
Kounis
Geoge-N
GN
Department of Medical Sciences, Patras Highest Institute of Education and Technology, Queel Olgas Square Patras 26221, Greece.
Kouni
Sophia-A
SA
Hahalis
George
G
Kounis
Nicholas-G
NG
D000789:Angina, Unstable / Q000139:chemically induced / Q000175:diagnosis*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D008297:Male; D019804:Mesalamine / Q000009:adverse effects* / Q000627:therapeutic use; D009203:Myocardial Infarction / Q000139:chemically induced / Q000175:diagnosis*; D013577:Syndrome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D019804:Mesalamine