title: [Tuberous sclerosis in childhood].
abstract: Tuberous sclerosis is an autosomal dominant disease that results from mutations in one of two tumor suppressor genes, TSC1 and TSC2. We are reporting a two-year-old girl who presented with hypopigmented macules (ash leaf) in the skin and small erythematous facial papules (angiofibromas). Her mother was known to have tuberous sclerosis that was diagnosed at age seven. Although the signs of tuberous sclerosis were specifically looked for in this patient because of her mother, subtle angiofibromas in a young child can be easily missed.
authors.forename: Catarina Fernandes
authors.initials: CF
authors.lastname: Pires
authors.forename: Genise Mayara Alves Da Silva
authors.initials: GM
authors.lastname: Anunciação
authors.forename: Wecilândia Lopes
authors.initials: WL
authors.lastname: De Sousa
authors.forename: Bertha Maria De Moura
authors.initials: BM
authors.lastname: Santos
authors.forename: Fernando Antonio Costa
authors.initials: FA
authors.lastname: Anunciação
authors.forename: Anália Fernandes
authors.initials: AF
authors.lastname: Pires
authors.forename: Lúcio Fernandes
authors.initials: LF
authors.lastname: Pires
mesh_terms: D018322:Angiofibroma / Q000209:etiology*; D002675:Child, Preschool; D005153:Facial Neoplasms / Q000209:etiology*; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D017496:Hypopigmentation / Q000209:etiology; D008279:Magnetic Resonance Imaging; D014057:Tomography, X-Ray Computed; D014402:Tuberous Sclerosis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology