Synthesis of enamides via Rh/C-catalyzed direct hydroacylation of ketoximes.
Enamides were efficiently prepared via a novel Rh/C-catalyzed direct hydroacylation of ketoximes. Up to 88% isolated yield of enamides were obtained with this method. Subsequent asymmetric hydrogenation of the enamides with Rh/DuanPhos complex gave the corresponding chiral amine in excellent enantioselectivities (up to 99.7% ee).
Guan
Zheng-Hui
ZH
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China.
Huang
Kexuan
K
Yu
Shichao
S
Zhang
Xumu
X
D000215:Acylation; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D010091:Oximes / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013696:Temperature
D000588:Amines; D010091:Oximes; D002244:Carbon; D012238:Rhodium