Oral versus intravenous administration of cyclophosphamide: a case report.
BACKGROUND
Cyclophosphamide, an alkylating agent, has been used as an immunosuppressant in the treatment of various autoimmune disorders and malignancies. It is highly capable of reducing T and B lymphocytes.


METHODS
Regular blood tests are important to detect bone marrow suppression. The risk of opportunistic infection such as pneumonia secondary to pneumocystic carinii increases drastically with lymphopaenia. Hence, prophylactic co-trimoxazole is frequently prescribed as long as patients are on cyclophosphamide.


CONCLUSIONS
The benefits and toxicity risks of intravenous versus oral administration of cyclophosphamide are described in this article.
Wu
Kenneth S
KS
Department of Nephrology, St James's University Hospital, Beckett Street, Leeds, LS9 7TF, UK. kenwu@doctors.org.uk.
Kwok
Chung
C
Lok
Aishin
A