title: [Case of cardial varices rupture due to danaparoid sodium with portal venous thrombosis].
abstract: A 54-year-old man had been admitted to Nara city hospital because of hematemesis and dyspnea caused by physical exertion, and was given a diagnosis of esophago-cardial varices and portal venous thrombosis. He was transferred to our hospital for further examinations and treatments. Ultrasonography (US) and computed tomography (CT) revealed the progression of portal venous thrombosis. Danaparoid sodium was administered to treat the portal vein thrombus. 5 days later, the patient was found to have hematemesis resulting from a cardial varices rupture. After endoscopic variceal ligation (EVL) and endoscopic injection sclerotherapy (EIS) was performed, danaparoid sodium was administered for 2 weeks. After the treatment, portal vein thrombus had almost disappeared. Due to an increased risk of bleeding, cases of esophago-cardial varices with portal venous thrombosis must be treated with care. This is the first report of upper gastrointestinal bleeding due to danaparoid sodium. Danaparoid sodium must be carefully administered when patients have portal venous thrombosis with delicate varices.
authors.affiliation: Third Department of Internal Medicine, Nara Medical University.
authors.forename: Hideto
authors.initials: H
authors.lastname: Kawaratani
authors.forename: Masahiko
authors.initials: M
authors.lastname: Matsumura
authors.forename: Tatsuhiro
authors.initials: T
authors.lastname: Tsujimoto
authors.forename: Tomoko
authors.initials: T
authors.lastname: Morimoto
authors.forename: Mitsuteru
authors.initials: M
authors.lastname: Kitade
authors.forename: Norie
authors.initials: N
authors.lastname: Umemoto
authors.forename: Kyouko
authors.initials: K
authors.lastname: Sakai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fukui
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects*; D002809:Chondroitin Sulfates / Q000009:adverse effects*; D003871:Dermatan Sulfate / Q000009:adverse effects*; D004932:Esophageal and Gastric Varices / Q000139:chemically induced* / Q000209:etiology / Q000628:therapy; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced* / Q000628:therapy; D006396:Hematemesis / Q000209:etiology; D006497:Heparan Sulfate / Q000009:adverse effects*; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications; D008297:Male; D008875:Middle Aged; D011169:Portal Vein; D015911:Sclerotherapy; D020246:Venous Thrombosis / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000925:Anticoagulants; D002809:Chondroitin Sulfates; D003871:Dermatan Sulfate; D006497:Heparan Sulfate; C035838:danaparoid