title: Novel trans-dichloridoplatinum(II) complexes with 3- and 4-acetylpyridine: Synthesis, characterization, DFT calculations and cytotoxicity.
abstract: Novel complexes of platinum(II) with 3- (1) or 4-acetylpyridine (2) have been synthesized and characterized by elemental analyses, IR, (1)H and (13)C NMR spectroscopy. Single crystal X-ray diffraction revealed the trans geometry of complex 2. DFT calculations confirm formation of trans isomers for both complexes. The complexes have been tested for their cytotoxicity against HeLa (human cervical cancer), U2OS (human osteosarcoma), U2OScisR (human osteosarcoma cisplatin resistant), B16 (murine melanoma), MDA-453, MDA-361, and MCF-7 (human breast cancer), LS-174 (human colon cancer) and FemX (human melanoma) cell lines. The most promising compound trans-dichloridobis(4-acetylpyridine)platinum(II) (2) overcomes cisplatin resistance of U2OScisR cells after 48h of drug exposure.
authors.affiliation: Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Serbia.
authors.forename: Gordana M
authors.initials: GM
authors.lastname: Rakić
authors.forename: Sanja
authors.initials: S
authors.lastname: Grgurić-Sipka
authors.forename: Goran N
authors.initials: GN
authors.lastname: Kaluderović
authors.forename: Santiago
authors.initials: S
authors.lastname: Gómez-Ruiz
authors.forename: Snezana K
authors.initials: SK
authors.lastname: Bjelogrlić
authors.forename: Sinisa S
authors.initials: SS
authors.lastname: Radulović
authors.forename: Zivoslav Lj
authors.initials: ZLj
authors.lastname: Tesić
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D017671:Platinum Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D017671:Platinum Compounds; D011725:Pyridines; C010835:3-acetylpyridine; C055538:4-acetylpyridine