title: [The role of osteocalcin in the connection of bone and glucose metabolism in humans].
abstract: The lack of osteoblast derived osteocalcin in mice causes reduced pancreatic beta-cell proliferation, decreased expression of insulin gene and adiponectin gene in adipocytes as well.
  
  
  METHODS
  The relationship between insulin sensitivity, osteocalcin and bone state in 45 healthy (20 females, 25 males) and 92 glucose intolerant (51 females, 41 males) subjects was examined. Body composition, bone density, markers of bone resorption and formation as well as glucose uptake (M value for insulin sensitivity) measured by hyperinsulinemic normoglycemic clamp were determined separately in males and females.
  
  
  RESULTS
  Osteocalcin levels were similar in the two genders, however, glucose intolerant men had lower osteocalcin levels than healthy men (24.5+/-11 vs. 18.1+/-9 ng/ml, p < 0.05). In the healthy group, we found positive correlation between osteocalcin and muscle M values (females: r = +0.319, p < 0.05, males: r = 0.481, p < 0.01), although this relationship disappeared in the glucose intolerant groups. Osteocalcin did not show correlation with adiponectin level in any of the genders. Based on a multivariate regression analysis, in all females significant independent predictors of osteocalcin level were fasting blood glucose, whole and lean body mass glucose uptake, metabolic clearance rate, estradiol and LDL-cholesterol levels (determined 92% of its value), while in all men these were serum calcium, OGTT glucose area under the curve, free fatty acid levels, insulogenic index, HOMA-R and waist/hip ratio (determined 95% of its value). The BMU index characterizing bone resorption/formation correlated significantly with the M values only in women.
  
  
  CONCLUSIONS
  This study confirmed the relationship between insulin sensitivity and osteocalcin in healthy human population, although basic difference was found between the two genders which was not related to osteocalcin.
authors.affiliation: DRC Kft. Balatonfüred Ady E. u. 12. 8230.
authors.forename: Barbara
authors.initials: B
authors.lastname: Buday
authors.forename: Eniko
authors.initials: E
authors.lastname: Kulcsár
authors.forename: Botond
authors.initials: B
authors.lastname: Literáti Nagy
authors.forename: Tünde
authors.initials: T
authors.lastname: Horváth
authors.forename: Márta
authors.initials: M
authors.lastname: Vitai
authors.forename: Istvánné
authors.initials: I
authors.lastname: Vecsei
authors.forename: Katalin
authors.initials: K
authors.lastname: Bezzegh
authors.forename: József
authors.initials: J
authors.lastname: Kiss
authors.forename: Eva
authors.initials: E
authors.lastname: Péterfai
authors.forename: László
authors.initials: L
authors.lastname: Koltay
authors.forename: László
authors.initials: L
authors.lastname: Korányi
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D015519:Bone Density; D001862:Bone Resorption / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004958:Estradiol / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005947:Glucose / Q000378:metabolism*; D015309:Glucose Clamp Technique; D018149:Glucose Intolerance / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D015999:Multivariate Analysis; D015675:Osteocalcin / Q000097:blood / Q000378:metabolism*; D011237:Predictive Value of Tests; D012307:Risk Factors; D012737:Sex Factors; D049629:Waist-Hip Ratio
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D008078:Cholesterol, LDL; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D015675:Osteocalcin; D004958:Estradiol; D005947:Glucose; D002118:Calcium