Success rates and immunologic responses of autogenic, allogenic, and xenogenic treatments to repair articular cartilage defects.
This review examines current approaches available for articular cartilage repair, not only in terms of their regeneration potential, but also as a function of immunologic response. Autogenic repair techniques, including osteochondral plug transplantation, chondrocyte implantation, and microfracture, are the most widely accepted clinical treatment options due to the lack of immunogenic reactions, but only moderate graft success rates have been reported. Although suspended allogenic chondrocytes are shown to evoke an immune response upon implantation, allogenic osteochondral plugs and tissue-engineered grafts using allogenic chondrocytes exhibit a tolerable immunogenic response. Additionally, these repair techniques produce neotissue with success rates approaching those of currently available autogenic repair techniques, while simultaneously obviating their major hindrance of donor tissue scarcity. To date, limited research has been performed with xenogenic tissue, although several studies demonstrate the potential for its long-term success. This article focuses on the various treatment options for cartilage repair and their associated success rates and immunologic responses.
Revell
Christopher M
CM
Department of Bioengineering, Rice University, Houston, Texas 77005, USA.
Athanasiou
Kyriacos A
KA
D000818:Animals; D002357:Cartilage Diseases / Q000473:pathology / Q000601:surgery*; D002358:Cartilage, Articular / Q000637:transplantation*; D002645:Chickens; D019902:Chondrocytes / Q000637:transplantation*; D006736:Horses; D006801:Humans; D011817:Rabbits; D051381:Rats; D023822:Tissue Engineering / Q000379:methods*; D014180:Transplantation / Q000379:methods*; D014183:Transplantation, Heterologous / Q000379:methods*; D014184:Transplantation, Homologous / Q000379:methods*; D016896:Treatment Outcome