Clear cell papulosis.
A 2-year-old boy presented with multiple, hypopigmented, flat-topped papules in the pubic region and on the abdomen in a distribution pattern that followed the milk lines. The lesions had first appeared at age three months and increased in number over time. Histopathologic examination showed large clear cells within the lower epidermis, which stained positively with periodic acid-Schiff. These findings were diagnostic of clear cell papulosis, a rare condition that primarily affects young children. We review the histopathologic and immunohistochemical findings that link clear cell papulosis to clear cells of Toker and extramammary Paget disease.
Farley-Loftus
Rachel
R
Department of Dermatology, New York University, USA.
Bossenbroek
Nicole M
NM
Rosenman
Karla
K
Schaffer
Julie V
JV
D002675:Child, Preschool; D004817:Epidermis / Q000737:chemistry / Q000196:embryology / Q000473:pathology; D015622:Epithelioid Cells / Q000473:pathology; D006801:Humans; D017496:Hypopigmentation / Q000209:etiology; D008297:Male; D042361:Mammary Glands, Human / Q000196:embryology; D009077:Mucins / Q000032:analysis; D010145:Paget Disease, Extramammary / Q000473:pathology; D010503:Periodic Acid-Schiff Reaction; D017444:Skin Diseases, Papulosquamous / Q000150:complications / Q000175:diagnosis* / Q000473:pathology
D009077:Mucins