title: Genetic sub-structure in western Mediterranean populations revealed by 12 Y-chromosome STR loci.
abstract: Haplotype and allele frequencies of 12 Y-chromosome short tandem repeat (Y-STR) loci (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385 a/b, DYS437, DYS438 and DYS439) included in the Powerplex(R) Y System were determined in seven western Mediterranean populations from Valencia, Majorca, Ibiza (eastern Spain), Sicily and three Calabrian provinces (southern Italy). Amongst the 554 males included in the study, 443 different haplotypes were observed of which 372 were only observed once. The other haplotypes were shared by two to seven men. The overall haplotype diversity was 0.9988 +/- 0.0002. These Y-STRs markers showed a low capacity of discrimination (56.3%) in the Ibiza population probably due to genetic drift. Comparisons between the populations studied and other neighbouring populations showed a clear genetic sub-structure in the western Mediterranean area.
authors.affiliation: Institut Universitari d'Investigacions en Ciències de la Salut (IUNICS) i Laboratori de Genètica, Departament de Biologia, Universitat de les Illes Balears, Carretera de Valldemossa, km 7.5, 07122, Palma de Mallorca, Illes Balears, Spain.
authors.forename: V
authors.initials: V
authors.lastname: Rodríguez
authors.forename: C
authors.initials: C
authors.lastname: Tomàs
authors.forename: J J
authors.initials: JJ
authors.lastname: Sánchez
authors.forename: J A
authors.initials: JA
authors.lastname: Castro
authors.forename: M M
authors.initials: MM
authors.lastname: Ramon
authors.forename: A
authors.initials: A
authors.lastname: Barbaro
authors.forename: N
authors.initials: N
authors.lastname: Morling
authors.forename: A
authors.initials: A
authors.lastname: Picornell
mesh_terms: D041322:Chromosomes, Human, Y; D016172:DNA Fingerprinting; D005006:Ethnicity / Q000235:genetics; D005787:Gene Frequency; D014644:Genetic Variation; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D008297:Male; D019083:Mediterranean Region; D016133:Polymerase Chain Reaction; D020080:Tandem Repeat Sequences