title: A novel cyclic hexapeptide as chiral selector: Application for HPLC separation of a series of dansyl amino and arylalkanoic acids.
abstract: In this paper, the synthesis of a cyclic hexapeptide molecule was presented and evaluated for the enantiomer separation of a series of dansyl amino and arylalkanoic acids using high performance liquid chromatography (HPLC). It was clearly vizualized that this chiral selector allowed the separation of a great number of enantiomer pairs. The influences of the size and the hydrogen bonding donor (HBD) parameter of the organic modifier (OM) (THF (HBD=0.00), propan-2-ol (HBD=0.33), methanol (HBD=0.43)) added in the mobile phase were also investigated on both the enantiomer-chiral selector association and enantioseparation.
authors.affiliation: Equipe des Sciences Séparatives et Biopharmaceutiques (2SB)-EA 3924, Laboratoire de Chimie Analytique, Faculté de Médecine Pharmacie, Place Saint Jacques, 25030 Besançon, Cedex, France.
authors.forename: Claire
authors.initials: C
authors.lastname: André
authors.forename: Mireille
authors.initials: M
authors.lastname: Thomassin
authors.forename: Arunalyat
authors.initials: A
authors.lastname: Umrayami
authors.forename: Lhassane
authors.initials: L
authors.lastname: Ismaili
authors.forename: Bernard
authors.initials: B
authors.lastname: Refouvelet
authors.forename: Yves-Claude
authors.initials: YC
authors.lastname: Guillaume