title: Evaluation of spray congealing as technique for the preparation of highly loaded solid lipid microparticles containing the sunscreen agent, avobenzone.
abstract: Solid lipid microparticles (SLMs) loaded with high amounts of the sunscreen agent, butyl methoxydibenzoylmethane (avobenzone) were prepared in order to reduce its photoinstability. The microparticles were produced, using carnauba wax as lipidic material and phosphatidylcholine as the surfactant, by the classical melt dispersion method or the spray congealing technique with pneumatic atomizer. The sunscreen agent loading was 40.1-48.5% (w/w), with no significant differences between the production methods. However, release studies indicated that spray congealing enabled a more efficient modulation of avobenzone release from the SLMs (26% of encapsulated avobenzone released after 2 h as compared to 60% for melt dispersion). The photoprotective efficacy of the SLMs was evaluated after their introduction in a model cream. A statistically significant decrease of the light-induced degradation of avobenzone was obtained by the SLMs prepared by the melt dispersion procedure (the extent of degradation was 38.6 +/- 3.6% for nonencapsulated avobenzone and 32.1 +/- 4.3% for the microparticle-entrapped sunscreen). On the other hand, the SLMs produced by spray congealing achieved a more marked reduction in avobenzone photodecomposition to 15.4 +/- 4.1%. Therefore, the spray congealing technique was superior to the classical melt dispersion method for rapid and solvent free production of SLMs with a high avobenzone loading capacity.
authors.affiliation: Department of Pharmaceutical Sciences, University of Bologna, via S. Donato 19, Bologna, Italy.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Albertini
authors.forename: Matteo
authors.initials: M
authors.lastname: Mezzena
authors.forename: Nadia
authors.initials: N
authors.lastname: Passerini
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Rodriguez
authors.forename: Santo
authors.initials: S
authors.lastname: Scalia
mesh_terms: D002214:Capsules; D047188:Chalcones / Q000008:administration & dosage / Q000138:chemical synthesis*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004337:Drug Carriers / Q000008:administration & dosage / Q000138:chemical synthesis; D004353:Drug Evaluation, Preclinical / Q000379:methods; D008055:Lipids / Q000008:administration & dosage / Q000138:chemical synthesis*; D010316:Particle Size; D010782:Photolysis; D011427:Propiophenones; D013473:Sunscreening Agents / Q000008:administration & dosage / Q000138:chemical synthesis*; D014961:X-Ray Diffraction / Q000379:methods
chemical_list: D002214:Capsules; D047188:Chalcones; D004337:Drug Carriers; D008055:Lipids; D011427:Propiophenones; D013473:Sunscreening Agents; C049935:avobenzone