[Living related donor kidney transplantation: analysis of 117 cases].
OBJECTIVE
To summarize the clinical experience in living related donor kidney transplantation.


METHODS
117 patients with different nephropathies underwent transplantation of kidneys donated by their collateral relative in three generations. All donor kidneys were removed by open nephrectomy. Immunosuppressive protocols which consisting of cyclosporine A/tacrolimus, mycophenolate mofetil/azathioprine/rapamycin, and steroid were used in all patients as immunosuppressors. Follow-up was conducted for 1-44 months.


RESULTS
Delayed graft function recovery occurred in 2 patients. Acute rejection episodes occurred in 18 patients, and the condition was reversed by high intravenous dose of methyl-prednisolone or polyclonal anti-T-cell antibodies. Follow-up showed that all the patients survived with normal kidney function, and the donors kept good kidney function with normal life quality. Hypertension was found in 2 donors and diabetes mellitus was found in 1 donor.


CONCLUSIONS
Careful evaluation of both psychological and physical status of the donors and optimal physical status of recipients before operation are critical for successful kidney transplantation. Injury of graft kidney should be reduced and recipients should be treated with sufficient immunosuppressive regimen in early stage after transplantation.
Tian
Ye
Y
Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China. tianye166@126.com
Zhang
Lei
L
Xie
Ze-lin
ZL
Tang
Ya-wang
YW
Sun
Wen
W
Guo
Hong-bo
HB
Lin
Jun
J
Ji
Zheng-guo
ZG
D000328:Adult; D005190:Family; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged