RACK1, an excellent predictor for poor clinical outcome in oral squamous carcinoma, similar to Ki67.
OBJECTIVE
The aim of this study was to evaluate the significance of RACK1 in predicting outcome for patients with oral squamous cell carcinoma (OSCC) compared with Ki67.


METHODS
The expression of both RACK1 and Ki67 in 130 patients with OSCC was illustrated by using immunohistochemistry assay. Multiple logistic regression and Pearson's correlation coefficient were used. Recurrence versus non-recurrence of the malignant lesions was considered as the surrogate for clinical outcome of patients.


RESULTS
Multivariable logistic regression showed that the elevated RACK1 immunostaining was a factor having great influence on OSCC prognosis. RACK1 staining was strongly related to that of Ki67. The area under the receiver operating characteristic curve for both biomarkers in predicting recurrence was 0.72 and 0.70 respectively, indicating an excellent discrimination for RACK1 as well as for Ki67.


CONCLUSIONS
These data indicate that increased RACK1 expression is an important outcome predictor for OSCC compared with Ki67.
Wang
Zhi
Z
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, PR China.
Zhang
Ben
B
Jiang
Lu
L
Zeng
Xin
X
Chen
Yu
Y
Feng
Xiaodong
X
Guo
Yu
Y
Chen
Qianming
Q
D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000235:genetics; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000378:metabolism*; D009062:Mouth Neoplasms / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000378:metabolism*; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D000075370:Receptors for Activated C Kinase; D011956:Receptors, Cell Surface / Q000378:metabolism*; D012044:Regression Analysis
D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D009363:Neoplasm Proteins; D000075370:Receptors for Activated C Kinase; D011956:Receptors, Cell Surface