title: Relationship between interleukin-1 genotype and peri-implantitis: a literature review.
abstract: Endosseous implants present high survival rates within a 10-year observation time; however, implant failure and biologic complications are not completely avoidable. Although specific bacteria, dental plaque, and environmental factors are associated with peri-implant disease, there are currently no reliable predictors of peri-implantitis occurrence and severity. Disagreement about which clinical measures of peri-implant health are of diagnostic value continues because of the complexity of the disease process. Thus, identification of genes that control or modify aspects of the host response may provide a method to identify individuals at an elevated risk for peri-implant infections. Elevated levels of the inflammatory cytokine interleukin-1 (IL-1) in the crevicular fluid around diseased implants seem to play an important role in the pathogenesis and severity of peri-implantitis. The purpose of this review article was to critically address the genetic associations regarding IL-1 genotype claimed for peri-implant disease and to validate the use of IL-1 genetic susceptibility tests. It was revealed that the diagnostic value of both IL-1 genotyping and genetic tests for peri-implantitis should be reconsidered before altering treatment planning, regimens, and maintenance in implant dentistry.
authors.affiliation: School of Dentistry, Albert-Ludwigs University, Freiburg, Germany. marina.andreiotelli@uniklinik-freiburg.de
authors.forename: Marina
authors.initials: M
authors.lastname: Andreiotelli
authors.forename: Spiridon-Oumvertos
authors.initials: SO
authors.lastname: Koutayas
authors.forename: Phoebus N
authors.initials: PN
authors.lastname: Madianos
authors.forename: Jörg-Rudolf
authors.initials: JR
authors.lastname: Strub
mesh_terms: D003758:Dental Implantation, Endosseous / Q000009:adverse effects; D015921:Dental Implants / Q000009:adverse effects*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005883:Gingival Crevicular Fluid / Q000737:chemistry; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D010518:Periodontitis / Q000209:etiology / Q000235:genetics* / Q000276:immunology; D020641:Polymorphism, Single Nucleotide; D011237:Predictive Value of Tests
chemical_list: D015921:Dental Implants; D007375:Interleukin-1