[Intra-arterial chemotherapy and chemoembolization in the combined treatment for locally advanced carcinoma of the head and neck].
We evaluated the role of intra-arterial chemotherapy and/or chemoembolization, intravenous systemic chemotherapy and radiotherapy in combined treatment for locally advanced unresectable carcinoma of the head and neck. Transfemoral approach for catheterization with chemoinfusion/chemoembolization of the external carotid artery branches with carboplatin (300 mg/m2), 5-fluorouracil (1000 mg/m2) and gelatin sponge was attempted in 25 patients. Out of that number, 18 received additional radiotherapy. Bleeding episodes and relevant high risk in the future were indications for embolization treatment. There was complete (2) and partial (8) tumor regression or stabilization (5) (83%), progression (3) (17%). Arterial and systemic chemotherapy without irradiation resulted in one partial response, 3 cases of stabilization (57%), and 3 cases of progression (out of 7) (43%). There were no episodes of chronic tumor-related bleeding (7). Hence, combined treatment for locally advanced carcinoma of the head and neck including intra-arterial chemotherapy, chemoembolization, intravenous systemic chemotherapy and radiotherapy can be safely delivered with high response rates and low systemic toxicity. Since all these measures are accompanied by relatively low risks of chronic bleeding a choice of palliative or radical dosage of radiation is possible.
Sokurenko
V P
VP
Korytova
L I
LI
Tarazov
P G
PG
Suvorova
Iu V
IuV
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D002277:Carcinoma / Q000188:drug therapy* / Q000532:radiotherapy / Q000556:secondary; D016461:Chemoembolization, Therapeutic / Q000379:methods; D018450:Disease Progression; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D005781:Gelatin Sponge, Absorbable / Q000008:administration & dosage; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy; D006801:Humans; D007261:Infusions, Intra-Arterial; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D018714:Radiotherapy, Adjuvant; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D016190:Carboplatin; D005472:Fluorouracil