title: [A clinical analysis of methylmalonic acidemia in adolescents].
abstract: OBJECTIVE
  To investigate the clinical characteristics of methylmalonic academia in adolescence cases.
  
  
  METHODS
  4 cases were diagnosed methylmalonic academia by gas chromatography- mass spectrogram whose clinical, manifestations and treatment process were analyzed.
  
  
  RESULTS
  The main clinical manifestations in 4 cases with methylmalonic academia were intellect impairment, epilepsy, pyramid signs; 2 of them suffered with hypoplasia and optic atrophy, one of them suffered with papilledema. Symptoms were improved after treated with cobamamide and L-carnitine in all the 4 cases 1 months later.
  
  
  CONCLUSIONS
  The main clinical characteristics of methylmalonic academia in adolescence were intellect impairment, epilepsy and pyramid signs. The symptoms could be improved after treatment.
authors.affiliation: Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Ye
authors.forename: Cun-Jiang
authors.initials: CJ
authors.lastname: Li
authors.forename: Jiang-Hong
authors.initials: JH
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D005260:Female; D006801:Humans; D008297:Male; D008661:Metabolism, Inborn Errors / Q000175:diagnosis* / Q000453:epidemiology; D008764:Methylmalonic Acid / Q000097:blood*
chemical_list: D008764:Methylmalonic Acid