title: Evaluation of two methods for concentrating perrhenate (188 Re) eluates obtained from 188 W-188 Re generator.
abstract: Two novel and simple methods for post-elution concentration (PEC) of (188)Re-perrhenate, using (i) a single diethyl amino ethyl (DEAE) cellulose anion exchanger column and (ii) a combination of Dowex-1 x 8 and AgCl columns, are described here. In the first system, 20-25 ml of (188)Re-perrhenate in acidic ammonium acetate was trapped in the small anion exchanger column of DEAE cellulose which was subsequently recovered in 4 ml of normal saline. In the second method, (188)Re-perrhenate eluate in 20-40 ml normal saline was trapped on a small strong base anion exchanger column, Dowex-1 x 8, and recovered in 5 ml of 0.2M NaI solution and finally processed over 1g AgCl column so as to obtain it in physiological saline solution in a final volume of 6.5 ml including 1.5 ml de-ionized water washings. In both the methods, the radiochemical purity of (188)Re-perrhenate was >98% and (188)W breakthrough was less than 10(-3)%.
authors.affiliation: Board of Radiation and Isotope Technology (BRIT), BARC Vashi Complex, Navi Mumbai 400 705, India.
authors.forename: Sishir Kumar
authors.initials: SK
authors.lastname: Sarkar
authors.forename: Meera
authors.initials: M
authors.lastname: Venkatesh
authors.forename: Natesan
authors.initials: N
authors.lastname: Ramamoorthy
mesh_terms: D002852:Chromatography, Ion Exchange; D007202:Indicators and Reagents; D007475:Ion Exchange Resins; D008722:Methods; D011868:Radioisotopes / Q000302:isolation & purification*; D011876:Radionuclide Generators; D012211:Rhenium / Q000302:isolation & purification*
chemical_list: D007202:Indicators and Reagents; D007475:Ion Exchange Resins; D011868:Radioisotopes; C015428:perrhenate; D012211:Rhenium