title: The overexpression of major antioxidant enzymes does not extend the lifespan of mice.
abstract: We evaluated the effect of overexpressing antioxidant enzymes on the lifespans of transgenic mice that overexpress copper zinc superoxide dismutase (CuZnSOD), catalase, or combinations of either CuZnSOD and catalase or CuZnSOD and manganese superoxide dismutase (MnSOD). Our results show that the overexpression of these major antioxidant enzymes, which are known to scavenge superoxide and hydrogen peroxide in the cytosolic and mitochondrial compartments, is insufficient to extend lifespan in mice.
authors.affiliation: Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, 78229, USA.
authors.forename: Viviana I
authors.initials: VI
authors.lastname: Pérez
authors.forename: Holly
authors.initials: H
authors.lastname: Van Remmen
authors.forename: Alex
authors.initials: A
authors.lastname: Bokov
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Epstein
authors.forename: Jan
authors.initials: J
authors.lastname: Vijg
authors.forename: Arlan
authors.initials: A
authors.lastname: Richardson
mesh_terms: D000818:Animals; D002374:Catalase / Q000096:biosynthesis* / Q000235:genetics; D004195:Disease Models, Animal; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D008136:Longevity / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D018384:Oxidative Stress; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013482:Superoxide Dismutase / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D006861:Hydrogen Peroxide; D002374:Catalase; D013482:Superoxide Dismutase