Trafficking, a key player in regulated intramembrane proteolysis.
The term regulated intramembrane proteolysis (RIP) emerged from converging mechanisms aiming to release or activate signaling fragments or transcription factors from their respective membrane-anchored precursors. To date, four families of intramembrane proteases exist each of which process their own specific target substrates. As such, RIP initiates or abrogates a multitude of signaling cascades and plays a pivotal role in many physiological processes. The spatial and temporal localization of substrates versus proteases is of major importance in the diverse regulation of intramembrane proteolysis. Here we highlight the exciting conjunction between intracellular transport and RIP through the example of the routes taken by APP and its associated proteases.
Sannerud
Ragna
R
VIB, Department of Molecular and Developmental Genetics, Laboratory for Membrane Trafficking, Campus Gasthuisberg, Herestraat 49, O&N1, Box 602, 3000 Leuven, Belgium.
Annaert
Wim
W
D053829:Amyloid Precursor Protein Secretases / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D006801:Humans; D021381:Protein Transport; D015398:Signal Transduction
D016564:Amyloid beta-Protein Precursor; D053829:Amyloid Precursor Protein Secretases