CD8+ T-cells mediate immunopathology in tick-borne encephalitis.
Epidemics of tick-borne encephalitis involving thousands of humans occur annually in the forested regions of Europe and Asia. Despite the importance of this disease, the underlying basis for the development of encephalitis remains undefined. Here, we prove the key role of CD8(+) T-cells in the immunopathology of tick-borne encephalitis, as demonstrated by prolonged survival of SCID or CD8(-/-) mice, following infection, when compared with immunocompetent mice or mice with adoptively transferred CD8(+) T-cells. The results imply that tick-borne encephalitis is an immunopathological disease and that the inflammatory reaction significantly contributes to the fatal outcome of the infection.
Růzek
Daniel
D
Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, Ceské Budejovice, Czech Republic. ruzekd@paru.cas.cz
Salát
Jirí
J
Palus
Martin
M
Gritsun
Tamara S
TS
Gould
Ernest A
EA
Dyková
Iva
I
Skallová
Anna
A
Jelínek
Jirí
J
Kopecký
Jan
J
Grubhoffer
Libor
L
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology; D004675:Encephalitis, Tick-Borne / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007121:Immunocompetence / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology; D016513:Mice, SCID / Q000276:immunology*; D010243:Paralysis / Q000276:immunology / Q000469:parasitology; D013045:Species Specificity; D017741:Survivors; D019562:Viral Load