Performance of novel bioactive hybrid hydrogels in vitro and in vivo used for artificial cartilage.
The long-term fixation of poly(vinyl alcohol) PVA hydrogels cartilage implants on ambient tissue is a difficult problem, which is one of the obstacles for PVA hydrogels to be used as articular cartilage implants. In this work, a novel bioactive PVA/HA hydrogel was prepared by the in situ sol-gel synthesis method. Simulated experiments were performed to evaluate and compare the bioactive ability and properties of the hydrogels in simulated body fluid (SBF). Gradual-structure PVA/HA cartilage implants were developed and used to repair articular cartilage defects in rabbit knees. In vitro bioactive evaluation showed that PVA/HA hydrogels could be bio-mineralized to form bone-like hydroxyl-carbonate-apatite deposit in SBF solution. The macroscopic and histological observation of animal experiments displayed that the implanted hydrogels combined tightly with ambient tissues, and some bone-like tissue grew into the bottom of the implants from the base bone to form more deep-set binding between replacement and cartilage tissues.
Zheng
Yudong
Y
College of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, People's Republic of China. mcyzheng@vip.sina.com
Lv
Hexiang
H
Wang
Yingjun
Y
Lu
Huading
H
Qing
Liu
L
Xi
Tingfei
T
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D040761:Biomimetic Materials / Q000737:chemistry*; D002358:Cartilage, Articular / Q000293:injuries / Q000473:pathology / Q000601:surgery; D050724:Fractures, Cartilage / Q000473:pathology* / Q000601:surgery*; D020100:Hydrogels / Q000737:chemistry; D006882:Hydroxyapatites / Q000737:chemistry*; D008422:Materials Testing; D010316:Particle Size; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D019736:Prostheses and Implants; D011817:Rabbits; D013499:Surface Properties
D001672:Biocompatible Materials; D020100:Hydrogels; D006882:Hydroxyapatites; D011142:Polyvinyl Alcohol