title: Impact of preexisting circulating effector T cells on the outcome of ABO-incompatible adult LDLT.
abstract: Our aim was to clarify the significance of phenotype of circulating CD8 T(+) cells on the outcome of ABO-incompatible (ABO-I) living donor liver transplantation (LDLT). Twenty-six recipients undergoing ABO-I LDLT and 92 undergoing ABO-compatible (ABO-C) LDLT were classified into three groups according to preoperative proportion of CD8 T(+) cells: naive-dominant (group I), effector memory-dominant (group II), and effector-dominant (group III) recipients. The clinical courses were analyzed. The results showed that in ABO-C groups I and II and in ABO-I group I, effector cells remained above the pretransplant levels after tacrolimus administration. However, in ABO-C group III and ABO-I groups II and III, effector cells were down-regulated for a prolonged period, along with markedly decreased perforin expression and frequent life-threatening complications. ABO-I group II and group III recipients had higher infection rates. It was concluded that recipients with preexisting high effector CD8 T(+) cells are unfavorable candidates for ABO-I LDLT.
authors.affiliation: Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan. egawa@kuhp.kyoto-u.ac.jp
authors.forename: Hiroto
authors.initials: H
authors.lastname: Egawa
authors.forename: Kazue
authors.initials: K
authors.lastname: Ozawa
authors.forename: Yasutsugu
authors.initials: Y
authors.lastname: Takada
authors.forename: Satoshi
authors.initials: S
authors.lastname: Teramukai
authors.forename: Akira
authors.initials: A
authors.lastname: Mori
authors.forename: Mureo
authors.initials: M
authors.lastname: Kasahara
authors.forename: Kohei
authors.initials: K
authors.lastname: Ogawa
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ogura
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Oike
authors.forename: Toshimi
authors.initials: T
authors.lastname: Kaido
authors.forename: Masako
authors.initials: M
authors.lastname: Ono
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sato
authors.forename: Kenji
authors.initials: K
authors.lastname: Takai
authors.forename: Shinji
authors.initials: S
authors.lastname: Uemoto
mesh_terms: D000017:ABO Blood-Group System / Q000276:immunology*; D000328:Adult; D000368:Aged; D001787:Blood Group Incompatibility / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D016031:Liver Transplantation / Q000276:immunology*; D019520:Living Donors; D008297:Male; D008775:Methylprednisolone / Q000494:pharmacology; D008875:Middle Aged; D010641:Phenotype; D016559:Tacrolimus / Q000494:pharmacology
chemical_list: D000017:ABO Blood-Group System; D007166:Immunosuppressive Agents; D016559:Tacrolimus; D008775:Methylprednisolone