title: Presenilin: RIP and beyond.
abstract: Over the years the presenilins (PSENs), a family of multi-transmembrane domain proteins, have been ascribed a number of diverse potential functions. Recent in vivo evidence has supported the existence of PSEN functions beyond its well-established role in regulated intramembrane proteolysis. In this review, we will briefly discuss the ability of PSEN to modulate cellular signaling pathways through gamma-secretase cleavage of transmembrane proteins. Additionally, we will critically examine the proposed roles of PSEN in the regulation of beta-catenin function, protein trafficking, calcium regulation, and apoptosis.
authors.affiliation: Department of Developmental Biology, Washington University School of Medicine, Saint Louis, MO, United States.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Hass
authors.forename: Chihiro
authors.initials: C
authors.lastname: Sato
authors.forename: Raphael
authors.initials: R
authors.lastname: Kopan
authors.forename: Guojun
authors.initials: G
authors.lastname: Zhao
mesh_terms: D053829:Amyloid Precursor Protein Secretases / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D008954:Models, Biological; D053763:Presenilins / Q000378:metabolism*; D021381:Protein Transport; D015398:Signal Transduction
chemical_list: D008565:Membrane Proteins; D053763:Presenilins; D053829:Amyloid Precursor Protein Secretases