title: Enantioselective iridium-catalyzed allylic arylation.
abstract: We describe herein the development of the first iridium-catalyzed allylic substitution using arylzinc nucleophiles. High enantioselectivities were obtained from the reactions, which used commercially available Grignard reagents as the starting materials. This methodology was also shown to be compatible with halogen/metal exchange reactions. Its synthetic potential is demonstrated by its application towards the formal synthesis of (+)-sertraline.
authors.affiliation: Department of Organic Chemistry, University of Geneva, 30 quai Ernest Ansermet, 1211 Genève 4, Switzerland.
authors.forename: Damien
authors.initials: D
authors.lastname: Polet
authors.forename: Xavier
authors.initials: X
authors.lastname: Rathgeb
authors.forename: Caroline A
authors.initials: CA
authors.lastname: Falciola
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Langlois
authors.forename: Samir
authors.initials: S
authors.lastname: El Hajjaji
authors.forename: Alexandre
authors.initials: A
authors.lastname: Alexakis