title: [Effect of platelet rich plasma on the regeneration of cavernous nerve: experiment with rats].
abstract: OBJECTIVE
  To investigate the effect of platelet rich plasma (PRP) on the regeneration of injured cavernous nerve (CN).
  
  
  METHODS
  Blood was collected from the hearts of 6 SD rats to prepare PRP. 24 male adult rats were randomly divided into 3 equal groups: pure suture group undergoing bilateral CN transaction and pure suture immediately, PRP group undergoing bilateral CN transaction + suture + PRP 200 microl to the site of suture, and sham operation group. 3 months later intracavernous pressure (ICP) was measured by CN electrostimulation and then samples of CN were obtained to undergo pathological examination.
  
  
  RESULTS
  3 months later after surgery, the ICP of the pure suture group was (46 +/- 8) cm H2O, significantly lower than that of the sham group [(109 +/- 13) cm H2O, P < 0.01], and that of the PRP group was (94 +/- 13) cm H2O, significantly higher than that of the pure sutured group (P < 0.01), however, still significantly lower than that of the sham operation group (P < 0.05). The number of axons of CN in the PRP group was (121 +/- 16), significantly higher than that of the pure sutured group (70 +/- 14, P < 0.01); however, still significantly lower than that of the sham operation group (181 +/- 21, P < 0.01).
  
  
  CONCLUSIONS
  PRP can promote the regeneration of injured CN and the recovery of erectile function.
authors.affiliation: Department of Urology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China.
authors.forename: Xie-gang
authors.initials: XG
authors.lastname: Ding
authors.forename: Shi-wen
authors.initials: SW
authors.lastname: Li
authors.forename: Xin-min
authors.initials: XM
authors.lastname: Zheng
authors.forename: Li-quan
authors.initials: LQ
authors.lastname: Hu
authors.forename: Wan-li
authors.initials: WL
authors.lastname: Hu
authors.forename: Yi
authors.initials: Y
authors.lastname: Luo
mesh_terms: D000818:Animals; D008297:Male; D009416:Nerve Regeneration; D010413:Penis / Q000294:innervation* / Q000502:physiology*; D053657:Platelet-Rich Plasma; D051381:Rats; D017207:Rats, Sprague-Dawley