title: Pathological abnormalities after long-term administration of medroxyprogesterone acetate in a queen.
abstract: In this report, multiple abnormalities (bilateral ovarian cysts, cystic endometrial hyperplasia and pyometra (CEH-P), mammary adenoma, fibrosarcoma and cystic-papillary adenocarcinoma) identified in a queen continually administered medroxyprogesterone acetate (MPA) for 9 years are described. An 11-year-old domestic shorthair intact queen was presented for reduced appetite, polyuria, polydipsia, abdominal distension, and mammary mass. Pyometra was diagnosed based upon clinical, ultrasonographic and radiographic examinations. Mastectomy and ovariohysterectomy (OHE) were performed for treatment. Bilateral ovarian cysts were detected during OHE. Histopathologically, follicular ovarian cysts, CEH-P, and benign and neoplastic mammary lesions were identified. We suggest that, the pathological abnormalities may have been attributed to adverse effects of prolonged administration of MPA.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, University of Uludag, Gorukle 16059, Bursa, Turkey. kadirk@uludag.edu.tr
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Keskin
authors.forename: Gulnaz
authors.initials: G
authors.lastname: Yilmazbas
authors.forename: Rahsan
authors.initials: R
authors.lastname: Yilmaz
authors.forename: Musa O
authors.initials: MO
authors.lastname: Ozyigit
authors.forename: Ahmet
authors.initials: A
authors.lastname: Gumen
mesh_terms: D000231:Adenocarcinoma, Papillary / Q000139:chemically induced / Q000601:surgery / Q000662:veterinary*; D000818:Animals; D002371:Cat Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000601:surgery*; D002415:Cats; D003271:Contraceptive Agents, Female / Q000009:adverse effects*; D004714:Endometrial Hyperplasia / Q000139:chemically induced / Q000601:surgery / Q000662:veterinary; D005260:Female; D007044:Hysterectomy / Q000009:adverse effects; D015674:Mammary Neoplasms, Animal / Q000139:chemically induced* / Q000601:surgery; D017258:Medroxyprogesterone Acetate / Q000009:adverse effects*; D010052:Ovariectomy / Q000009:adverse effects; D055112:Pyometra / Q000139:chemically induced / Q000601:surgery / Q000662:veterinary*; D014463:Ultrasonography
chemical_list: D003271:Contraceptive Agents, Female; D017258:Medroxyprogesterone Acetate