title: Myoclonus of peripheral origin: two case reports.
abstract: The concept of peripheral myoclonus is not yet fully accepted by the medical community because of the difficulty in establishing a cause-and-effect relationship between trauma and subsequent movement disorders. Here, we report two cases of patients suffering from peripheral myoclonus after nerve injury. The first patient experienced myoclonus of the 4th dorsal interosseous muscle several days after trauma to the elbow. The second patient presented myoclonus of the arm stump (combined with phantom-limb pain) 1 year after amputation. In both cases, central nervous system function (spine and brain imaging, somesthetic evoked potentials, EEG back-averaging) was normal. For the second patient, local infiltration of xylocaine and botulinum toxin into the stump scar rapidly stopped myoclonus and pain. Nerve injury induces ephaptic transmission and ectopic excitation. The physiopathological mechanisms of this type of myoclonus involve a peripheral generator that induces central (spinal) generator activity.
authors.affiliation: Department of Neurology and Movement Disorders, Lille University Hospital, Lille Cedex, France.
authors.forename: Louise
authors.initials: L
authors.lastname: Tyvaert
authors.forename: Pierre
authors.initials: P
authors.lastname: Krystkowiak
authors.forename: Francois
authors.initials: F
authors.lastname: Cassim
authors.forename: Elise
authors.initials: E
authors.lastname: Houdayer
authors.forename: Alexandre
authors.initials: A
authors.lastname: Kreisler
authors.forename: Alain
authors.initials: A
authors.lastname: Destée
authors.forename: Luc
authors.initials: L
authors.lastname: Defebvre
mesh_terms: D000293:Adolescent; D000672:Amputation Stumps / Q000503:physiopathology*; D000870:Anterior Horn Cells / Q000502:physiology; D018726:Anti-Dyskinesia Agents / Q000627:therapeutic use; D001134:Arm Injuries / Q000601:surgery; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use; D001917:Brachial Plexus / Q000293:injuries* / Q000503:physiopathology; D002574:Cervical Vertebrae; D002921:Cicatrix / Q000503:physiopathology; D004576:Electromyography; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009207:Myoclonus / Q000188:drug therapy / Q000209:etiology*; D009431:Neural Conduction; D010292:Paresthesia / Q000209:etiology; D010591:Phantom Limb / Q000150:complications; D010812:Physical Stimulation / Q000009:adverse effects; D013128:Spinal Osteophytosis / Q000150:complications; D014459:Ulnar Nerve / Q000293:injuries* / Q000503:physiopathology; D000092464:Elbow Injuries
chemical_list: D018726:Anti-Dyskinesia Agents; D008012:Lidocaine; D019274:Botulinum Toxins, Type A