title: Triprenylated flavonoids from Dorstenia psilurus and their alpha-glucosidase inhibition properties.
abstract: Six new unusual C-4'-prenylated flavonols, dorsilurins F-K (1-6), together with six known compounds were isolated from the roots of Dorstenia psilurus, and their structures were elucidated on the basis of spectroscopic evidence. The isolated compounds exhibited moderate to low alpha-glucosidase inhibitory activity. Dorsilurin F (1), with three unmodified prenyl groups, was the most active, while dorsilurin K (6), with only one unmodified prenyl group, was the least active compound. Furthermore, NMR data of dorsilurin C (7), isolated some years ago from the same plant, have been revised.
authors.affiliation: Organic Chemistry Department, University of Yaoundé I, P.O. Box 8664, Yaoundé, Cameroon. ttabopda@yahoo.fr
authors.forename: Turibio K
authors.initials: TK
authors.lastname: Tabopda
authors.forename: Joseph
authors.initials: J
authors.lastname: Ngoupayo
authors.forename: Patrice K
authors.initials: PK
authors.lastname: Awoussong
authors.forename: Anne-Claire
authors.initials: AC
authors.lastname: Mitaine-Offer
authors.forename: Muhammad S
authors.initials: MS
authors.lastname: Ali
authors.forename: Bonaventure T
authors.initials: BT
authors.lastname: Ngadjui
authors.forename: Marie-Aleth
authors.initials: MA
authors.lastname: Lacaille-Dubois
mesh_terms: D002163:Cameroon; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D015394:Molecular Structure; D029586:Moraceae / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D005419:Flavonoids; D065089:Glycoside Hydrolase Inhibitors; C534641:dorsilurin F