title: Intra-abdominal hypertension: incidence and association with organ dysfunction during early septic shock.
abstract: OBJECTIVE
  The objective of this article is to study the cumulative incidence of intra-abdominal hypertension (IAH) in septic shock (SS) patients during the first 72 hours of intensive care unit (ICU) admission and to determine if the presence and severity of IAH are associated with sepsis morbidity and mortality.
  
  
  METHODS
  Eighty-one consecutive SS patients admitted to a surgical-medical ICU of an academic university hospital (January 2005 to January 2006) were included. Intra-abdominal pressure (IAP) and abdominal perfusion pressure (APP) were measured every 6 h (intermittently) for 72 h. Intra-abdominal pressure was registered as minimal, mean, and maximal values per day, during shock and throughout the study period. Intra-abdominal hypertension was diagnosed if IAP remained 12 mm Hg or higher on 2 consecutive measurements and stratified according to the most recent consensus definition (www.wsacs.org).
  
  
  RESULTS
  According to maximal and mean IAP values, 67 (82.7%) and 62 (76.5%) of the patients developed IAH during the study period, respectively. Mean IAP values remained stable throughout the study period. Surgical patients had a higher incidence of IAH than medical patients (93% vs 73%, P < .009). Maximal IAPs were normally distributed, with nonsurvivors exhibiting significantly higher IAP levels during shock (survivors, 17.2 +/- 5.3; nonsurvivors, 19.9 +/- 5.6 mm Hg; P < .04). Patients with IAH exhibited significantly lower values of APP and diuresis, higher values of lactate and creatinine, and higher maximal norepinephrine doses, and were more frequently mechanically ventilated (P < .05 for all). Increasing degrees of IAH and the development of the abdominal compartment syndrome were associated with lower APP and higher maximal serum creatinine levels (P < .03 for both).
  
  
  CONCLUSIONS
  Septic shock patients have a very high incidence of IAH, which seems to be associated with the severity of shock and could be related to the development of organ dysfunctions, particularly renal dysfunction. Intra-abdominal pressure should be routinely monitored during the course of SS.
authors.affiliation: Department of Intensive Care Medicine, Pontificia Universidad Católica De Chile, Santiago, Chile.
authors.forename: Tomas
authors.initials: T
authors.lastname: Regueira
authors.forename: Alejandro
authors.initials: A
authors.lastname: Bruhn
authors.forename: Pablo
authors.initials: P
authors.lastname: Hasbun
authors.forename: Marcia
authors.initials: M
authors.lastname: Aguirre
authors.forename: Carlos
authors.initials: C
authors.lastname: Romero
authors.forename: Osvaldo
authors.initials: O
authors.lastname: Llanos
authors.forename: Ricardo
authors.initials: R
authors.lastname: Castro
authors.forename: Guillermo
authors.initials: G
authors.lastname: Bugedo
authors.forename: Glenn
authors.initials: G
authors.lastname: Hernandez
mesh_terms: D018806:APACHE; D000005:Abdomen; D003161:Compartment Syndromes / Q000453:epidemiology* / Q000401:mortality / Q000503:physiopathology; D005260:Female; D006439:Hemodynamics; D006785:Hospitals, University; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000453:epidemiology* / Q000401:mortality / Q000503:physiopathology; D011312:Pressure; D011446:Prospective Studies; D012772:Shock, Septic / Q000401:mortality / Q000503:physiopathology*