Expedient synthesis of 3-alkoxymethyl- and 3-aminomethyl-pyrazolo[3,4-b]pyridines.
An effective strategy has been developed for the preparation of 3-alkoxymethyl-pyrazolo[3,4-b]pyridines, compounds that are currently not readily accessible by existing synthetic methods. Further manipulation of these compounds allows for access to 3-alkoxymethyl-pyrazolo[3,4-b]pyridines with a variety of substitution patterns as well as 3-aminomethyl-pyrazolo[3,4-b]pyridines.
Beutner
Gregory L
GL
Department of Process Research, Merck and Co., Inc., PO Box 2000, Rahway, New Jersey 07065, USA. gregory_beutner@merck.com
Kuethe
Jeffrey T
JT
Kim
Mary M
MM
Yasuda
Nobuyoshi
N
D007700:Kinetics; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry
C521930:2-fluoropyridine; D011720:Pyrazoles; D011725:Pyridines; C118531:pyrazolopyridine