title: Highly diastereoselective Zn/SnCl2-mediated gem-difluoroallylation of chiral hydrazones.
abstract: gem-Difuoroallylic zinc reacts with chiral hydrazones 1 in the presence of SnCl(2) to afford the versatile and chiral fluorinated building blocks, gem-difluorohomoallylic amines, in good yields and high diastereoselectivities.
authors.affiliation: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China.
authors.forename: Xuyi
authors.initials: X
authors.lastname: Yue
authors.forename: Xingang
authors.initials: X
authors.lastname: Zhang
authors.forename: Feng-Ling
authors.initials: FL
authors.lastname: Qing
mesh_terms: D000478:Alkylation; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D006835:Hydrazones / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D017971:Tin Compounds / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
chemical_list: D000588:Amines; D006835:Hydrazones; D017971:Tin Compounds; C023599:stannous chloride; D015032:Zinc