title: Macrophages and Fc-receptor interactions contribute to the antitumour activities of the anti-CD40 antibody SGN-40.
abstract: SGN-40 is a therapeutic antibody targeting CD40, which induces potent anti-lymphoma activities via direct apoptotic signalling cells and by cell-mediated cytotoxicity. Here we show antibody-dependent cellular phagocytosis (ADCP) by macrophages to contribute significantly to the therapeutic activities and that the antitumour effects of SGN-40 depend on Fc interactions.
authors.affiliation: Department of Preclinical Therapeutics, Seattle Genetics Inc., Seattle, WA 98021, USA.
authors.forename: E
authors.initials: E
authors.lastname: Oflazoglu
authors.forename: I J
authors.initials: IJ
authors.lastname: Stone
authors.forename: L
authors.initials: L
authors.lastname: Brown
authors.forename: K A
authors.initials: KA
authors.lastname: Gordon
authors.forename: N
authors.initials: N
authors.lastname: van Rooijen
authors.forename: M
authors.initials: M
authors.lastname: Jonas
authors.forename: C-L
authors.initials: CL
authors.lastname: Law
authors.forename: I S
authors.initials: IS
authors.lastname: Grewal
authors.forename: H-P
authors.initials: HP
authors.lastname: Gerber
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D019013:CD40 Antigens / Q000276:immunology*; D045744:Cell Line, Tumor; D006801:Humans; D008223:Lymphoma / Q000188:drug therapy*; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D016513:Mice, SCID; D010587:Phagocytosis; D011961:Receptors, Fc / Q000502:physiology*
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D019013:CD40 Antigens; D011961:Receptors, Fc