title: Can intracytoplasmic morphologically selected sperm injection be used to select normal-sized sperm heads in infertile patients with macrocephalic sperm head syndrome?
abstract: OBJECTIVE
  To study the chromosomal content of spermatozoa selected by intracytoplasmic morphologically selected sperm injection (IMSI) in cases of macrocephalic sperm head syndrome.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Obstetrics, gynecology, urology, and reproductive biology departments.
  
  
  METHODS
  Two infertile patients with large-headed spermatozoa.
  
  
  METHODS
  Fluorescence in situ hybridization on selected spermatozoa with normal-sized heads after IMSI selection.
  
  
  METHODS
  Percentages of polyploid, diploid, haploid aneuploid, and normal spermatozoa.
  
  
  RESULTS
  Of the six spermatozoa that could be selected, all were haploid but aneuploid.
  
  
  CONCLUSIONS
  Absence of normal haploid spermatozoa among high magnification-selected spermatozoa contraindicated IMSI for these two patients.
authors.affiliation: Department of Reproductive Biology and Cytogenetics, Centre Hospitalier Poissy, Saint Germain, France.
authors.forename: Mohamed Hassen
authors.initials: MH
authors.lastname: Chelli
authors.forename: Martine
authors.initials: M
authors.lastname: Albert
authors.forename: Pierre F
authors.initials: PF
authors.lastname: Ray
authors.forename: Bruno
authors.initials: B
authors.lastname: Guthauser
authors.forename: Vincent
authors.initials: V
authors.lastname: Izard
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Hammoud
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Selva
authors.forename: François
authors.initials: F
authors.lastname: Vialard
mesh_terms: D000782:Aneuploidy; D053713:Azoospermia / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D006801:Humans; D007248:Infertility, Male / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy*; D008297:Male; D013077:Sperm Head / Q000502:physiology*; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods*; D013094:Spermatozoa / Q000002:abnormalities / Q000502:physiology; D013577:Syndrome