Suppressing NFAT increases VEGF signaling in hemangiomas.
Infantile hemangiomas represent the most common tumor of endothelial cell (EC) origin, yet the mechanisms regulating hemangioma EC behavior are poorly understood. A new study by Jinnin et al. demonstrates that enhanced VEGFR2 signaling in hemangioma ECs is caused by suppression of NFAT (nuclear factor of activated T cells)-dependent VEGFR1 expression.
Acevedo
Lisette M
LM
Department of Pathology and Moores UCSD Cancer Center, University of California, San Diego, La Jolla, CA 92093-0803, USA.
Cheresh
David A
DA
D000818:Animals; D002465:Cell Movement; D049109:Cell Proliferation; D006391:Hemangioma / Q000378:metabolism*; D006801:Humans; D016023:Integrins / Q000378:metabolism; D008954:Models, Biological; D050778:NFATC Transcription Factors / Q000378:metabolism*; D015398:Signal Transduction; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000378:metabolism*; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000378:metabolism
D016023:Integrins; D050778:NFATC Transcription Factors; D042461:Vascular Endothelial Growth Factor A; D040281:Vascular Endothelial Growth Factor Receptor-1; D040301:Vascular Endothelial Growth Factor Receptor-2