title: Integrated network analysis platform for protein-protein interactions.
abstract: There is an increasing demand for network analysis of protein-protein interactions (PPIs). We introduce a web-based protein interaction network analysis platform (PINA), which integrates PPI data from six databases and provides network construction, filtering, analysis and visualization tools. We demonstrated the advantages of PINA by analyzing two human PPI networks; our results suggested a link between LKB1 and TGFbeta signaling, and revealed possible competitive interactors of p53 and c-Jun.
authors.affiliation: Genome-Scale Biology Program, Institute of Biomedicine, University of Helsinki, Haartmaninkatu 8, Helsinki, Finland. jianmin.wu@helsinki.fi
authors.forename: Jianmin
authors.initials: J
authors.lastname: Wu
authors.forename: Tea
authors.initials: T
authors.lastname: Vallenius
authors.forename: Kristian
authors.initials: K
authors.lastname: Ovaska
authors.forename: Jukka
authors.initials: J
authors.lastname: Westermarck
authors.forename: Tomi P
authors.initials: TP
authors.lastname: Mäkelä
authors.forename: Sampsa
authors.initials: S
authors.lastname: Hautaniemi
mesh_terms: D030541:Databases, Genetic; D006801:Humans; D011485:Protein Binding; D025941:Protein Interaction Mapping / Q000379:methods*; D011506:Proteins / Q000032:analysis* / Q000378:metabolism*; D013379:Substrate Specificity
chemical_list: D011506:Proteins