Rafting in the membrane. A lesson learnt from lymphoproliferative disorders.
Lipid rafts are chemically distinct compartments of the plasma membrane. Their integrity is a prerequisite for vital cellular functions particularly for signalling and trafficking. Their perturbation is associated with development of a broad spectrum of diseases. Lipid rafts are also important for therapeutic effects of some drugs. Moreover, some of the raft associated molecules are useful immunohistochemical markers in routine histopathology.
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Department of Cellular Pathology, James Cook University Hospital, Middlesbrough, United Kingdom. alexandr.svec@stees.nhs.uk
D000818:Animals; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000503:physiopathology*; D021962:Membrane Microdomains / Q000502:physiology*; D014777:Virus Diseases / Q000503:physiopathology