title: [Analysis of short chain fatty acids in gingival crevicular fluid of patients with aggressive periodontitis].
abstract: OBJECTIVE
  To investigate 7 short chain fatty acids (SCFA) concentrations in gingival crevicular fluid (GCF) of aggressive periodontitis (AgP) and to analyze the relationship between levels of SCFA and AgP clinical parameters.
  
  
  METHODS
  GCF was collected from 152 sites of 38 AgP patients and 56 sites of 14 healthy subjects. Formic acid, succinic acid, acetic acid, lactic acid, propionic acid, butyric acid and isovalerianic acid were detected by high performance capillary electrophoresis.
  
  
  RESULTS
  The concentrations of succinic acid, acetic acid, lactic acid, propionic acid, butyric acid and isovalerianic acid in GCF were significantly higher in AgP patients than in healthy group, while formic acid was lower in GCF of AgP group compared with healthy group. Correlation analysis showed that formic acid was negatively correlated with bleeding index (BI), probing depth (PD) and attachment loss (AL), while BI was positively correlated with succinic acid, acetic acid, lactic acid, propionic acid and butyric acid; PD and AL were positively correlated with succinic acid, acetic acid, propionic acid, butyric acid and isovalerianic acid.
  
  
  CONCLUSIONS
  The elevation of succinic acid, acetic acid, propionic acid, butyric acid and isovalerianic acid concentrations in GCF may be related with AgP destruction condition, while formic acid concentration was reduced.
authors.affiliation: Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing 100081, China.
authors.forename: Rui-fang
authors.initials: RF
authors.lastname: Lu
authors.forename: Huan-xin
authors.initials: HX
authors.lastname: Meng
authors.forename: Xue-jun
authors.initials: XJ
authors.lastname: Gao
authors.forename: Lin
authors.initials: L
authors.lastname: Feng
authors.forename: Li
authors.initials: L
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D010520:Aggressive Periodontitis / Q000503:physiopathology*; D002087:Butyrates / Q000032:analysis; D016022:Case-Control Studies; D005232:Fatty Acids, Volatile / Q000032:analysis*; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D006801:Humans; D008297:Male; D011422:Propionates / Q000032:analysis; D055815:Young Adult
chemical_list: D002087:Butyrates; D005232:Fatty Acids, Volatile; D011422:Propionates; C029658:propionic acid