title: Cucurbituril-based nanoparticles: a new efficient vehicle for targeted intracellular delivery of hydrophobic drugs.
abstract: Cucurbituril-based nanoparticles (CB[6]NPs) serve as new efficient vehicles for delivery of hydrophobic drugs, which have unique features including (1) a high drug loading capacity and efficiency, (2) noncovalently tunable surfaces, (3) efficient delivery of hydrophobic drugs into a cancer cell by receptor-mediated endocytosis, and (4) facile release of drugs into cytoplasm, which enhances the pharmaceutical effects of the drugs.
authors.affiliation: Department of Chemistry, Pohang University of Science and Technology, Pohang, 790-784, Korea.
authors.forename: Kyeng Min
authors.initials: KM
authors.lastname: Park
authors.forename: Kyungwon
authors.initials: K
authors.lastname: Suh
authors.forename: Hyuntae
authors.initials: H
authors.lastname: Jung
authors.forename: Don-Wook
authors.initials: DW
authors.lastname: Lee
authors.forename: Youngjoo
authors.initials: Y
authors.lastname: Ahn
authors.forename: Jeeyeon
authors.initials: J
authors.lastname: Kim
authors.forename: Kangkyun
authors.initials: K
authors.lastname: Baek
authors.forename: Kimoon
authors.initials: K
authors.lastname: Kim
mesh_terms: D004396:Coloring Agents; D003593:Cytoplasm / Q000187:drug effects / Q000378:metabolism; D016503:Drug Delivery Systems; D006367:HeLa Cells; D006801:Humans; D047028:Macrocyclic Compounds / Q000737:chemistry; D018613:Microscopy, Confocal; D053758:Nanoparticles / Q000737:chemistry*; D010078:Oxazines; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D014677:Pharmaceutical Vehicles / Q000737:chemistry*; D010777:Photochemistry; D012995:Solubility; D014867:Water; D000099246:Cucurbit(n)urils
chemical_list: D004396:Coloring Agents; D047028:Macrocyclic Compounds; D010078:Oxazines; D004364:Pharmaceutical Preparations; D014677:Pharmaceutical Vehicles; D014867:Water; D000099246:Cucurbit(n)urils; C044808:nile red