Disruption of lipid rafts enhances the effect of lactobacilli on the production of tumor necrosis factor-alpha in mononuclear blood cells.
We investigated, to determine whether disruption of lipid rafts would influence the effect of three selected strains of Lactobacillus on TNF-alpha production by peripheral blood mononuclear cells. Two strains increased TNF-alpha production; and the third one reduced cytokine levels. Disruption of rafts changed the immunomodulatory effect of the three strains. This is the first report on a potential role of rafts in lactobacilli-cell interaction.
Soria
Mario
M
Center of Reference for Lactobacilos, CONICET, Tucumán, Argentina.
Mechoud
Mónica
M
Martin DE Quevedo
Angela
A
Font DE Valdez
Graciela
G
V Rodriguez
Ana
A
D000818:Animals; D001773:Blood Cells / Q000166:cytology* / Q000378:metabolism* / Q000382:microbiology; D002467:Cell Nucleus; D006801:Humans; D007223:Infant; D007778:Lactobacillus / Q000502:physiology*; D021962:Membrane Microdomains / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D014409:Tumor Necrosis Factor-alpha