title: Sulfamides as novel histone deacetylase inhibitors.
abstract: The sulfamide moiety has been utilized to design novel HDAC inhibitors. The potency and selectivity of these inhibitors were influenced both by the nature of the scaffold, and the capping group. Linear long-chain-based analogs were primarily HDAC6-selective, while analogs based on the lysine scaffold resulted in potent HDAC1 and HDAC6 inhibitors.
authors.affiliation: Department of Medicinal Chemistry, MethylGene Inc., 7220 rue Frederick-Banting, Montreal, Que., Canada H4S 2A1. wahhaba@methylgene.com
authors.forename: Amal
authors.initials: A
authors.lastname: Wahhab
authors.forename: David
authors.initials: D
authors.lastname: Smil
authors.forename: Alain
authors.initials: A
authors.lastname: Ajamian
authors.forename: Martin
authors.initials: M
authors.lastname: Allan
authors.forename: Yves
authors.initials: Y
authors.lastname: Chantigny
authors.forename: Eric
authors.initials: E
authors.lastname: Therrien
authors.forename: Natalie
authors.initials: N
authors.lastname: Nguyen
authors.forename: Sukhdev
authors.initials: S
authors.lastname: Manku
authors.forename: Silvana
authors.initials: S
authors.lastname: Leit
authors.forename: Jubrail
authors.initials: J
authors.lastname: Rahil
authors.forename: Andrea J
authors.initials: AJ
authors.lastname: Petschner
authors.forename: Ai-Hua
authors.initials: AH
authors.lastname: Lu
authors.forename: Alina
authors.initials: A
authors.lastname: Nicolescu
authors.forename: Sylvain
authors.initials: S
authors.lastname: Lefebvre
authors.forename: Samuel
authors.initials: S
authors.lastname: Montcalm
authors.forename: Marielle
authors.initials: M
authors.lastname: Fournel
authors.forename: Theresa P
authors.initials: TP
authors.lastname: Yan
authors.forename: Zuomei
authors.initials: Z
authors.lastname: Li
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Besterman
authors.forename: Robert
authors.initials: R
authors.lastname: Déziel
mesh_terms: D000577:Amides / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D056572:Histone Deacetylase Inhibitors
chemical_list: D000577:Amides; D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors