[Lamivudine treatment of a HBs antigen positive man with reactive arthritis].
A 46-year-old man who was HBs antigen positive since childhood had painful talocrural arthritis that was considered re-active to HBs antigen. Lamivudine treatment was started and HBV-DNA disappeared from the blood, and the joint swellings disappeared. HBe antibody disappeared after eight months. After one year and nine months lamivudine was discontinued, resulting in a flare of the hepatitis after 56 days: HBV-DNA rose to 40 million copies per ml and HBe antigen became positive. Lamivudine was reinstituted, resulting in normalization of ALAT and lowering of HBV-DNA under detection level.
Borup
Christian
C
Medicinsk Afdeling, Sygehus Sønderjylland Haderslev, DK-6100 Haderslev.
Siboni
Anders
A
D000998:Antiviral Agents / Q000627:therapeutic use*; D016918:Arthritis, Reactive / Q000188:drug therapy* / Q000821:virology; D004279:DNA, Viral / Q000097:blood; D006510:Hepatitis B Antibodies / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000097:blood; D019694:Hepatitis B, Chronic / Q000188:drug therapy*; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use*; D016896:Treatment Outcome
D000998:Antiviral Agents; D004279:DNA, Viral; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D018894:Reverse Transcriptase Inhibitors; D019259:Lamivudine