title: CROSS technique: chemical reconstruction of skin scars method.
abstract: Skin scars remain a therapeutic challenge to dermatologists. Over the past several decades, numerous surgical techniques have been used to improve the appearance of scarring. The objective of this study is to evaluate the efficacy of a local application of a (50%) concentration of trichloroacetic acid (TCA) for the treatment of atrophic acne scars (grade 3 in Goodman classification), as opposed to the higher (90%) TCA concentration used in previous studies, in order to reduce adverse local effects. The primary goal was the resolution of acne or chickenpox scars. Secondary goals were physician and subject assessments of scar improvement. Fifty percent TCA was applied locally to atrophic scars in five patients. Three patients had treated scars on the face and two patients had treated scars on the back. Wooden applicators were used to apply TCA locally and the treatment was repeated at 4-week intervals for a total of three sessions. Digital photographic analysis of lesions supported clinical observations. Histologic examination was performed only on two samples of patients with treated scars on the back. Clinical examination revealed cosmetic improvements in both depth and appearance of skin scars. We believe that the 50% TCA CROSS can be an effective technique for the treatment of atrophic scars.
authors.affiliation: Department of Dermatology and Venereology, University of Naples Federico II, Naples, Italy. gafabbro@unina.it
authors.forename: G
authors.initials: G
authors.lastname: Fabbrocini
authors.forename: S
authors.initials: S
authors.lastname: Cacciapuoti
authors.forename: N
authors.initials: N
authors.lastname: Fardella
authors.forename: F
authors.initials: F
authors.lastname: Pastore
authors.forename: G
authors.initials: G
authors.lastname: Monfrecola
mesh_terms: D000152:Acne Vulgaris / Q000150:complications* / Q000473:pathology / Q000628:therapy; D000328:Adult; D002615:Chemexfoliation / Q000379:methods*; D002921:Cicatrix / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D003879:Dermatologic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D017060:Patient Satisfaction; D010865:Pilot Projects; D013997:Time Factors; D016896:Treatment Outcome; D014238:Trichloroacetic Acid / Q000627:therapeutic use*
chemical_list: D003879:Dermatologic Agents; D014238:Trichloroacetic Acid