Pentafluorosulfanyl as a novel building block for enzyme inhibitors: trypanothione reductase inhibition and antiprotozoal activities of diarylamines.
Stump
Bernhard
B
Laboratorium für Organische Chemie, ETH Zürich, Hönggerberg, HCI, Zürich, Switzerland.
Eberle
Christian
C
Schweizer
W Bernd
WB
Kaiser
Marcel
M
Brun
Reto
R
Krauth-Siegel
R Luise
RL
Lentz
Dieter
D
Diederich
François
F
D000588:Amines / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D000981:Antiprotozoal Agents; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D056890:Eukaryota / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D009247:NADH, NADPH Oxidoreductases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000737:chemistry* / Q000494:pharmacology*
D000588:Amines; D000981:Antiprotozoal Agents; D004791:Enzyme Inhibitors; D013438:Sulfhydryl Compounds; D009247:NADH, NADPH Oxidoreductases; C049608:trypanothione reductase