title: Analysis of mutations in father-son pairs with 17 Y-STR loci.
abstract: We have examined 389 father/son sample pairs from U.S. Caucasians, African Americans, Hispanics and Asians using the 17 Y-STR loci in the Yfilertrade mark kit and observed a total of 24 differences between father and son. Thirteen mutations resulted in the gain of a repeat in the son and 11 resulted in a loss of a repeat. All samples resulted in single repeat mutations except one sample which contained a two repeat loss at Y-GATA-H4. Furthermore, two different sample pairs were found to have two mutations. An African American sample pair had a mutation at DYS458 and a second at DYS635 and an Asian sample pair had mutations at DYS439 and Y-GATA-H4.
authors.affiliation: Biochemical Science Division, National Institute of Sciences and Technology, Gaithersburg, MD 20899-8311, USA. amy.decker@nist.gov
authors.forename: Amy E
authors.initials: AE
authors.lastname: Decker
authors.forename: Margaret C
authors.initials: MC
authors.lastname: Kline
authors.forename: Janette W
authors.initials: JW
authors.lastname: Redman
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Reid
authors.forename: John M
authors.initials: JM
authors.lastname: Butler
mesh_terms: D001741:Black or African American / Q000235:genetics; D000483:Alleles; D044466:Asian People / Q000235:genetics; D002648:Child; D041322:Chromosomes, Human, Y; D016172:DNA Fingerprinting / Q000379:methods; D005220:Fathers; D017353:Gene Deletion; D020440:Gene Duplication; D005828:Genetics, Population; D006239:Haplotypes; D006630:Hispanic or Latino / Q000235:genetics; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D009154:Mutation; D009679:Nuclear Family; D016133:Polymerase Chain Reaction; D014481:United States; D044465:White People / Q000235:genetics