[Clinical analysis of assistant treatment proposals for infertile women with polycystic ovary syndrome].
OBJECTIVE
To study the clinical outcomes of assistant treatment proposals for infertile women with polycystic ovary syndrome (PCOS).


METHODS
PCOS patients were divided into four groups according to the assistant treatment proposals between Jan 2003 and Dec 2007 in Reproductive Medicine Center of the Provincial Hospital Affiliated to Shandong University. The four proposals were letrozole (LE) or clomiphene (CC) citrate ovulation induction group, in vitro fertilization and embryo transplantation group, ultrasound-guided immature follicle puncture group, and in vitro maturation and fertilization of oocytes from unstimulated cycles group. The treatment results were analyzed.


RESULTS
(1) The ovulation rate was 66% (38/58) vs 47% (21/45). The mean endometrial thickness [(0.89 +/- 0.13) vs (0.78 +/- 0.08) cm] and cervical mucus score (11.9 +/- 1.8 vs 9.9 +/- 1.8) on the day of human chorionic gonadotropin (hCG) administration in LE group were both higher than that in CC group, while mature follicle (1.08 +/- 0.28 vs 1.73 +/- 0.59) and serum estradiol level [(983 +/- 138) vs (1676 +/- 372) pmol/L] in LE group were lower than that in CC group (P < 0.05). (2) One southend five hundred and eighty-four patients accepted in vitro fertilization-embryo transplantation therapy because of PCOS (PCOS group) and 1615 patients because of tube factors (control group). The patients' ages and infertility years were matched between the two groups. Total doses of Gn [(980 +/- 1192) vs (1194 +/- 1389) IU] of PCOS group were lower than those of control group. The mean days of using gonadotropin [(9.6 +/- 1.8) vs (9.5 +/- 1.8) d], serum estradiol (E(2)) levels on the hCG day [(15 752 +/- 6206) vs (9675 +/- 4818) pmol/L], mean obtained oocytes (21 +/- 6 vs 9 +/- 3), mean fertilized oocytes (15 +/- 6 vs 7 +/- 3) and mean cleavaged oocytes (12.9 +/- 5.7 vs 5.7 +/- 2.8) of PCOS group were higher than those of the control group (P < 0.05). Moderate and severe ovarian hyperstimulation syndrome (OHSS) rates (4.86% vs 1.67%) of PCOS group were higher than that of the control group. The pregnant rate (44.7% vs 45.0%)of PCOS group was similar to the control group (P > 0.05). (3) One hundred and nine PCOS patients were given ultrasound-guided immature follicle puncture therapy. After treatment, the testosterone level, luteinizing hormone (LH) level and LH/follicle stimulating hormone (FSH) ratio of the patients became normal. The basic follicle number decreased. (4) A total of 304 in vitro maturation cycles were performed. After embryo transfer, 76 pregnancies were reported.


CONCLUSIONS
There are many choices for the infertile patients with PCOS, such as LE or CC citrate ovulation induction, in vitro fertilization and embryo transplantation, ultrasound-guided immature follicle puncture, and in vitro maturation and fertilization of oocytes from unstimulated cycles. We can provide individualized treatment according to the medical treatment conditions, doctors' professional capability and the patients' situation.
Chen
Zi-Jiang
ZJ
Reproductive Medicine Center of Provincial Hospital Affiliated to Shandong University, Jinan 250021, China. zjchen59@yahoo.com
Shi
Yu-Hua
YH
Li
Yuan
Y
Gao
Qin
Q
Sheng
Yan
Y
Ma
Zeng-Xiang
ZX
D000328:Adult; D002996:Clomiphene / Q000627:therapeutic use*; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D000077289:Letrozole; D009570:Nitriles / Q000627:therapeutic use*; D009865:Oocytes / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D016471:Ovarian Hyperstimulation Syndrome / Q000453:epidemiology; D010062:Ovulation Induction / Q000379:methods; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000628:therapy*; D011247:Pregnancy; D011677:Punctures; D027724:Reproductive Techniques, Assisted; D012189:Retrospective Studies; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*
D009570:Nitriles; D014230:Triazoles; D002996:Clomiphene; D000077289:Letrozole