title: Association of ACE I/D gene polymorphism with vascular dementia: a meta-analysis.
abstract: BACKGROUND
  Vascular dementia is the second common cause of dementia, only second to Alzheimer's disease in later life, and has a greater mortality risk than Alzheimer's disease among the elderly population group. The angiotensin-converting enzyme insertion/deletion polymorphism as a risk factor in vascular dementia has been suggested, but direct evidence from genetic association studies remain inconclusive. We performed a meta-analysis pooling data from all relevant studies in order to determine the effect of the insertion/deletion polymorphism on the vascular dementia.
  
  
  METHODS
  We applied a random-effects model or fixed-effects model to combine odds ratio and 95% confidence intervals. Q statistic was used to evaluate the homogeneity, and Egger's test and Funnel plot were used to assess publication bias.
  
  
  RESULTS
  A total of 10 studies were included worldwide. Publication bias was not observed. There was no evidence of the association of angiotensin-converting enzyme insertion/deletion polymorphism with the vascular dementia in general or in the Asian populations or in the Caucasian populations.
  
  
  CONCLUSIONS
  The angiotensin-converting enzyme insertion/deletion polymorphism might be neutral to vascular dementia.
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Sichuan Province, PR China.
authors.forename: Hua
authors.initials: H
authors.lastname: Liu
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Bo
authors.initials: B
authors.lastname: Wu
authors.forename: Shi-hong
authors.initials: SH
authors.lastname: Zhang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Fang
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015140:Dementia, Vascular / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D054643:INDEL Mutation; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D012307:Risk Factors
chemical_list: D007703:Peptidyl-Dipeptidase A