The recognition and surgical management of heritable lesions of the pancreas.
Our knowledge regarding the inherited factors that lead to the development of lesions within the pancreas is clearly incomplete. This article addresses clinical issues in patients at moderate-to-high risk for pancreatic malignancy, with special emphasis on the recognition and diagnosis of known genetic syndromes. Using the current available information, the authors attempt to equip the practicing surgeon with critical information to increase clinical suspicion for heritable syndromes and inform specific surgical management. Additionally, this article is meant to encourage the practicing surgeon to participate in the genetic testing/screening, cancer surveillance, and prevention activities of patients who have heritable cancer syndromes and associated pancreatic lesions that require surgery.
Kim
Michael P
MP
Department of Surgical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Evans
Douglas B
DB
Vu
Thuy M
TM
Fleming
Jason B
JB
D001943:Breast Neoplasms / Q000175:diagnosis / Q000601:surgery; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis / Q000601:surgery; D004416:Dysplastic Nevus Syndrome / Q000175:diagnosis / Q000601:surgery; D005260:Female; D016147:Genes, Tumor Suppressor; D005820:Genetic Testing; D006801:Humans; D008297:Male; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery*; D010195:Pancreatitis / Q000150:complications / Q000235:genetics; D010580:Peutz-Jeghers Syndrome / Q000175:diagnosis / Q000601:surgery; D011159:Population Surveillance; D006623:von Hippel-Lindau Disease / Q000175:diagnosis / Q000601:surgery