[Effect of shugan jiannao tiaoyu tablets (SJTT) on hypothalamic corticotrophin releasing hormone gene expression in model rat of post-stroke depression].
OBJECTIVE
To study the anti-depressive mechanism of Shugan Jiannao Tiaoyu tablets (SJTT) and provide evidence for clinical application.


METHODS
Evaluate the behavioral index changes of rat model through the methods of motionless-time of swimming by force, and the consumption of sucrose, etc, meanwhile, use transmission electron microscope (TEM) to observe the cell ultrastructure and study the influence of the hypothalamic corticotrophin releasing hormone (HCRH) gene expression with the RT-PCR technique.


RESULTS
SJTI could reduce the hippocampal neuronal damage caused by stress, protect the brain injury of the depressive rats. SJTT could down-regulate model rats' HCRH. Compared with the model group (P < 0.05), which indicates that SJTT could inhibit the hyperfunction of HPA Axis by down-regulating model rats' HCRH, to achieve the antidepressant effect.
Zhang
Jin-sheng
JS
The First Affiliated Hospital of Henan College of Traditional Chinese Medicine. zjssir2004@sina.com.cn
D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000235:genetics*; D003863:Depression / Q000473:pathology; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects*; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D046529:Microscopy, Electron, Transmission; D051381:Rats; D017207:Rats, Sprague-Dawley; D020133:Reverse Transcriptase Polymerase Chain Reaction
D004365:Drugs, Chinese Herbal; D003346:Corticotropin-Releasing Hormone