title: Type of alcoholic beverage and risk of head and neck cancer--a pooled analysis within the INHANCE Consortium.
abstract: The authors pooled data from 15 case-control studies of head and neck cancer (9,107 cases, 14,219 controls) to investigate the independent associations with consumption of beer, wine, and liquor. In particular, they calculated associations with different measures of beverage consumption separately for subjects who drank beer only (858 cases, 986 controls), for liquor-only drinkers (499 cases, 527 controls), and for wine-only drinkers (1,021 cases, 2,460 controls), with alcohol never drinkers (1,124 cases, 3,487 controls) used as a common reference group. The authors observed similar associations with ethanol-standardized consumption frequency for beer-only drinkers (odds ratios (ORs) = 1.6, 1.9, 2.2, and 5.4 for < or =5, 6-15, 16-30, and >30 drinks per week, respectively; P(trend) < 0.0001) and liquor-only drinkers (ORs = 1.6, 1.5, 2.3, and 3.6; P < 0.0001). Among wine-only drinkers, the odds ratios for moderate levels of consumption frequency approached the null, whereas those for higher consumption levels were comparable to those of drinkers of other beverage types (ORs = 1.1, 1.2, 1.9, and 6.3; P < 0.0001). Study findings suggest that the relative risks of head and neck cancer for beer and liquor are comparable. The authors observed weaker associations with moderate wine consumption, although they cannot rule out confounding from diet and other lifestyle factors as an explanation for this finding. Given the presence of heterogeneity in study-specific results, their findings should be interpreted with caution.
authors.affiliation: National Cancer Institute, Bethesda, Maryland, USA. purduem@mail.nih.gov
authors.forename: Mark P
authors.initials: MP
authors.lastname: Purdue
authors.forename: Mia
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authors.lastname: Hashibe
authors.forename: Julien
authors.initials: J
authors.lastname: Berthiller
authors.forename: Carlo
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authors.forename: Luigino
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authors.lastname: Dal Maso
authors.forename: Rolando
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authors.forename: Silvia
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authors.lastname: Franceschi
authors.forename: Xavier
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authors.lastname: Castellsague
authors.forename: Qingyi
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authors.initials: EM
authors.lastname: Sturgis
authors.forename: Hal
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authors.lastname: Morgenstern
authors.forename: Zuo-Feng
authors.initials: ZF
authors.lastname: Zhang
authors.forename: Fabio
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authors.lastname: Levi
authors.forename: Renato
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authors.lastname: Talamini
authors.forename: Elaine
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authors.lastname: Smith
authors.forename: Joshua
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authors.lastname: Muscat
authors.forename: Philip
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authors.lastname: Lazarus
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Schwartz
authors.forename: Chu
authors.initials: C
authors.lastname: Chen
authors.forename: Jose Eluf
authors.initials: JE
authors.lastname: Neto
authors.forename: Victor
authors.initials: V
authors.lastname: Wünsch-Filho
authors.forename: David
authors.initials: D
authors.lastname: Zaridze
authors.forename: Sergio
authors.initials: S
authors.lastname: Koifman
authors.forename: Maria Paula
authors.initials: MP
authors.lastname: Curado
authors.forename: Simone
authors.initials: S
authors.lastname: Benhamou
authors.forename: Elena
authors.initials: E
authors.lastname: Matos
authors.forename: Neonilia
authors.initials: N
authors.lastname: Szeszenia-Dabrowska
authors.forename: Andrew F
authors.initials: AF
authors.lastname: Olshan
authors.forename: Juan
authors.initials: J
authors.lastname: Lence
authors.forename: Ana
authors.initials: A
authors.lastname: Menezes
authors.forename: Alexander W
authors.initials: AW
authors.lastname: Daudt
authors.forename: Ioan Nicolae
authors.initials: IN
authors.lastname: Mates
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Pilarska
authors.forename: Eleonora
authors.initials: E
authors.lastname: Fabianova
authors.forename: Peter
authors.initials: P
authors.lastname: Rudnai
authors.forename: Debbie
authors.initials: D
authors.lastname: Winn
authors.forename: Gilles
authors.initials: G
authors.lastname: Ferro
authors.forename: Paul
authors.initials: P
authors.lastname: Brennan
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
authors.forename: Richard B
authors.initials: RB
authors.lastname: Hayes
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects*; D000434:Alcoholic Beverages / Q000009:adverse effects*; D001515:Beer / Q000009:adverse effects; D016022:Case-Control Studies; D000431:Ethanol / Q000009:adverse effects*; D006258:Head and Neck Neoplasms / Q000139:chemically induced / Q000453:epidemiology* / Q000209:etiology*; D006801:Humans; D016017:Odds Ratio; D018570:Risk Assessment; D012307:Risk Factors; D014920:Wine / Q000009:adverse effects
chemical_list: D000431:Ethanol