Effects of electric field stress on a beta-amyloid peptide.
The interaction of beta-amyloid (Abeta) peptides with externally applied electric fields (EF) of varying strengths was investigated by means of molecular dynamics (MD) simulations. The results suggest that the EF favors the switch of Abeta-peptides from helical to beta-sheet conformation, and a mechanism is tentatively proposed. Switching off the field does not restore the original conformation.
Toschi
Francesca
F
Dipartimento di Chimica, Universita di Bologna, 40126 Bologna, Italy.
Lugli
Francesca
F
Biscarini
Fabio
F
Zerbetto
Francesco
F
D016229:Amyloid beta-Peptides / Q000737:chemistry*; D003198:Computer Simulation; D008968:Molecular Conformation; D010446:Peptide Fragments / Q000737:chemistry*; D017433:Protein Structure, Secondary; D013995:Time
D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40)