Near-infrared spectroscopy applications in pharmaceutical analysis.
Near-infrared (NIR) spectroscopy is a fast and non-destructive analytical technique that offers many advantages for a broad range of industrial applications. In this work, we reviewed recent developments in the pharmaceutical domain where it can be applied from raw material identification to final product release. The characteristics of NIR allow the technique to be implemented as a process analytical technology (PAT). Moreover, recent instrumental developments open the perspectives of numerous applications in the NIR imaging area. After "Introduction", according to their subject, the applications are discussed in the parts "Identification", "Water content", "Assay" and "Other applications".
Luypaert
J
J
Department of Analytical Chemistry and Pharmaceutical Technology, Pharmaceutical Institute, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090 Brussel, Belgium.
Massart
D L
DL
Vander Heyden
Y
Y