title: Time-course of contrast enhancement in spleen and liver with Exia 160, Fenestra LC, and VC.
abstract: OBJECTIVE
  The purpose of this study was to compare the time-course of contrast-enhancement in spleen and liver using Exia 160 in comparison with Fenestra LC and VC in healthy mice.
  
  
  METHODS
  Healthy C57bl/6 mice were used in this study. Fenestra LC and VC was administered intravenously at a dose of 0.1 ml/20 g or 0.2 ml/20 g. Exia 160 at a dose of 0.05 ml/20 g or 0.1 ml/20 g. Each animal underwent a micro-CT scan before contrast injection (baseline) and immediately after contrast injection. Additional scans were performed at 1, 2, 3, 4, 24, and 48 h after contrast administration. The mice who received Exia 160 were also scanned after 15, 30, and 45 min.
  
  
  RESULTS
  The peak enhancement of Exia 160 occurred after 15 min for the spleen and after 30 min for the liver.
  
  
  CONCLUSIONS
  Exia 160 allows rapid spleen and liver enhancement. The high iodine content results in small injection volumes.
authors.affiliation: In vivo Cellular and Molecular Imaging-ICMI, Vrije Universiteit Brussel, Brussels, Belgium. inneke.willekens@gmail.com
authors.forename: Inneke
authors.initials: I
authors.lastname: Willekens
authors.forename: Tony
authors.initials: T
authors.lastname: Lahoutte
authors.forename: Nico
authors.initials: N
authors.lastname: Buls
authors.forename: Christian
authors.initials: C
authors.lastname: Vanhove
authors.forename: Rudi
authors.initials: R
authors.lastname: Deklerck
authors.forename: Axel
authors.initials: A
authors.lastname: Bossuyt
authors.forename: Johan
authors.initials: J
authors.lastname: de Mey
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008099:Liver / Q000000981:diagnostic imaging* / Q000378:metabolism; D008297:Male; D008657:Metabolic Clearance Rate; D051379:Mice; D008810:Mice, Inbred C57BL; D017711:Nonlinear Dynamics; D011877:Radionuclide Imaging; D013154:Spleen / Q000000981:diagnostic imaging* / Q000378:metabolism; D013997:Time Factors; D055114:X-Ray Microtomography / Q000379:methods*
chemical_list: D003287:Contrast Media