Diphenylprolinol silyl ether as a catalyst in an enantioselective, catalytic michael reaction for the formation of alpha,alpha-disubstituted alpha-amino acid derivatives.
Direct and enantioselective: Diphenylprolinol silyl ether was found to catalyze the direct, asymmetric Michael reaction of 4-substituted 2-aryl-2-oxazoline-5-one and alpha,beta-unsaturated aldehydes, affording the chiral alpha,alpha-disubstituted alpha-amino acid derivatives with excellent enantioselectivity.
Hayashi
Yujiro
Y
Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan. hayashi@ci.kagu.tus.ac.jp
Obi
Kazuki
K
Ohta
Yusuke
Y
Okamura
Daichi
D
Ishikawa
Hayato
H
D000596:Amino Acids / Q000737:chemistry*; D002384:Catalysis; D004987:Ethers / Q000737:chemistry*; D010080:Oxazoles / Q000737:chemistry; D011392:Proline / Q000031:analogs & derivatives* / Q000737:chemistry; D013237:Stereoisomerism
D000596:Amino Acids; D004987:Ethers; D010080:Oxazoles; C529940:diphenylprolinol silyl ether; D011392:Proline