title: [Acute poisoning with neonicotinoid insecticide acetamiprid].
abstract: Acetamiprid belongs to a new class of insecticides called neonicotinoids, which have different effects from other insecticides. Neonicotinoids act as selective agonists at the nicotinic acetylcholine receptors, therefore their toxicity is higher to insect pests than to humans. Cases of acetamiprid poisoning are still rare, because neonicotinoids have been released in the market only within the last decade. We experienced a case of acute acetamiprid poisoning and measured the blood concentration of acetamiprid. A 79-year-old man had ingested acetamiprid and got medical attention two hours after ingestion. On arrival, he had consciousness disturbance (GCS-8), hypotension, nausea, vomiting and hyperglycemia, but had no constricted pupils nor mucous supersecretion which are characteristic in organophosphate poisoning. Gastric lavage was performed and activated charcoal and laxative were administered. Paroxysmal atrial fibrillation persisted until 11 hours after ingestion. The next day, his symptoms with regards to the effects of acetamiprid improved and he was discharged from the hospital without complication. Blood concentration of acetamiprid on arrival, approximately 2 hours after the ingestion, was 21.1 microg/ml.
authors.affiliation: Advanced Medical Emergency and Critical Care Center, Yamaguchi University Hospital, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Todani
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kaneko
authors.forename: Hiromi
authors.initials: H
authors.lastname: Hayashida
authors.forename: Kotaro
authors.initials: K
authors.lastname: Kaneda
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Tsuruta
authors.forename: Shunji
authors.initials: S
authors.lastname: Kasaoka
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Maekawa
mesh_terms: D000208:Acute Disease; D000818:Animals; D002606:Charcoal / Q000627:therapeutic use; D019343:Citric Acid / Q000627:therapeutic use; D005751:Gastric Lavage; D006801:Humans; D007306:Insecticides / Q000097:blood / Q000506:poisoning*; D054368:Laxatives / Q000627:therapeutic use; D008297:Male; D000073943:Neonicotinoids; D009942:Organometallic Compounds / Q000627:therapeutic use; D011725:Pyridines / Q000097:blood / Q000506:poisoning*; D011978:Receptors, Nicotinic; D013406:Suicide, Attempted; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D007306:Insecticides; D054368:Laxatives; D000073943:Neonicotinoids; D009942:Organometallic Compounds; D011725:Pyridines; D011978:Receptors, Nicotinic; D002606:Charcoal; D019343:Citric Acid; C464485:acetamiprid; C110422:magnesium citrate