Lanostane-type triterpenes from the mushroom Astraeus pteridis with antituberculosis activity.
Bioassay-guided fractionation of an EtOH extract of the truffle-mimiking mushroom Astraeus pteridis led to the isolation and identification of three new (3-5) and two known (1, 2) lanostane triterpenes and phenylalanine betaine (6). The structures of the isolates were elucidated on the basis of 1D and 2D NMR spectroscopic data, HRESIMS results, and X-ray crystallographic analysis. Compounds 5 and 1 showed moderate activity against Mycobacterium tuberculosis with MIC values of 34.0 and 58.0 microg/mL, respectively.
Stanikunaite
Rita
R
Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA.
Radwan
Mohamed M
MM
Trappe
James M
JM
Fronczek
Frank
F
Ross
Samir A
SA
D000363:Agaricales / Q000737:chemistry*; D000818:Animals; D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D007810:Lanosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D009922:Oregon; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014709:Vero Cells
D000995:Antitubercular Agents; D014315:Triterpenes; D007810:Lanosterol