title: [Avian influenza and perspectives on vaccination against pandemic influenza].
abstract: We may expect that the next influenza pandemic will affect about half the world's population within a year and that it will cause unpredictable mortality rates. In this perspective, we review the molecular mechanisms underlying the development of new pandemic influenza strains and a discussion on existing and future vaccination strategies directed towards prevention of pandemic influenza is presented. There is an urgent need to develop paninfluenza-specific vaccines and invest substantially in new technologies in order to better meet this threat.
authors.affiliation: Institut for International Sundhed, Immunologi og Mikrobiologi, Panum Instituttet, Københavns Universitet, bygning 22.5, DK-2200 København N. p.holst@immi.ku.dk
authors.forename: Peter Johannes
authors.initials: PJ
authors.lastname: Holst
authors.forename: Jan Pravsgaard
authors.initials: JP
authors.lastname: Christensen
authors.forename: Allan Randrup
authors.initials: AR
authors.lastname: Thomsen
mesh_terms: D000818:Animals; D001717:Birds; D003140:Communicable Disease Control; D004196:Disease Outbreaks / Q000517:prevention & control; D014943:Global Health; D006801:Humans; D009980:Influenza A virus / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage*; D005585:Influenza in Birds / Q000453:epidemiology; D007251:Influenza, Human / Q000453:epidemiology / Q000401:mortality / Q000517:prevention & control
chemical_list: D007252:Influenza Vaccines