[Effect of qishen huoxue granule combined with fluconazole on survival rate of mice with systemic C. albaicans infection].
OBJECTIVE
To observe the effect of Qishen Huoxue Granule (QHG) combined with Fluconazole on the survival rate of mice with systemic C. albaicans (CA) infection.


METHODS
Deep CA infection model mice, with normal and low immunity, were established separately by injecting standard strain of CA via caudal vein, and were divided into 4 groups at random, treated by gastrogavage with normal saline (Group A), QHG (Group B) Fluconazole (FCZ, Group C) and QHG + FCZ (Group D) respectively, and a blank group was set up with normal mice for control. The survival time and the total survival rate in 30 days in various groups were recorded.


RESULTS
For mice with normal immunity, the survival rate in Group D and C was 79% and 78% respectively, showing no difference between them (P > 0.05). But for those with low immunity, it was 36% and 7% respectively, and the survival rate significantly higher in Group D than in Group C (P < 0.05).


CONCLUSIONS
As compared with those treated with FCZ alone, QHG combined with FCZ can raise the survival rate of the immuno-suppressed mice with systemic CA infection.
Li
Shi-rong
SR
Department of Infection and Critical Care Medicine, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing.
Wang
Hong
H
Zhang
Shu-wen
SW
D000818:Animals; D002176:Candida albicans / Q000187:drug effects / Q000502:physiology*; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality*; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D015725:Fluconazole / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011897:Random Allocation; D015996:Survival Rate
D004365:Drugs, Chinese Herbal; C534017:qishen huoxue; D015725:Fluconazole