title: Finegoldia magna, an early post-operative cause of infectious endocarditis: report of two cases and review of the literature.
abstract: We report two cases of infectious endocarditis (IE) on prosthetic valves caused by Finegoldia magna. The diagnosis was obtained by detection of the bacterium in valvular biopsies using 16S rRNA PCR amplication and sequencing, and prolonged culture. Five other cases were previously published in the literature. Following analysis of these seven cases, F. magna endocarditis presented as a subacute endocarditis, developing early (60 days) following valvular replacement (85%), with an elevated mortality (28%). Our report highlights the potential role of F. magna in early post-surgical endocarditis on prosthetic valves.
authors.affiliation: Fédération de Microbiologie, Hôpital de la Timone, Marseille Hôpital de la Timone, rue Saint Pierre, 13385 Marseille Cedex 5, France. Pierre-Edouard.Fournier@univmed.fr
authors.forename: Pierre-Edouard
authors.initials: PE
authors.lastname: Fournier
authors.forename: My Van
authors.initials: MV
authors.lastname: La
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Casalta
authors.forename: Hervé
authors.initials: H
authors.lastname: Richet
authors.forename: Frédéric
authors.initials: F
authors.lastname: Collart
authors.forename: Didier
authors.initials: D
authors.lastname: Raoult
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004275:DNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D004697:Endocarditis, Bacterial / Q000175:diagnosis* / Q000382:microbiology; D005260:Female; D020459:Genes, rRNA; D006094:Gram-Positive Bacteria / Q000302:isolation & purification*; D016908:Gram-Positive Bacterial Infections / Q000175:diagnosis* / Q000382:microbiology; D006350:Heart Valve Prosthesis / Q000382:microbiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010802:Phylogeny; D012329:RNA, Bacterial / Q000235:genetics; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid
chemical_list: D004269:DNA, Bacterial; D004275:DNA, Ribosomal; D012329:RNA, Bacterial; D012336:RNA, Ribosomal, 16S