Combined supplementation of soy and garlic modulate biochemical parameters of 7,12-dimethylbenz[alpha]anthracene induced mammary cancer in female albino rats.
The study was designed to investigate the chemoprotective effect of Combined Supplementation of soy and garlic on 7,12-dimethylbenz[alpha]anthrance (DMBA) induced mammary cancer in female Albino rats. Animals (eighty rats) where equally divided into four groups, (twenty rats each). Group I: each rat received 1 mL of 0.1% saline daily for twenty days. Group II: received 1 mL of 0.1% saline given orally once a day for twenty days after DMBA infusion (30 mg kg-1) and these rats served as controls (cancer control) for groups III and IV. Group III: were post treated with garlic after Infusion with DMBA. Group IV: Treated with Combined Supplementation of Soy and Garlic after DMBA infusion. Biochemical measurement were carried out on liver tissues and serum of experimental animals. Circulating levels of lactate dehydrogenase (LDH), glutamate oxaloacetate transaminase (GOT) and glutamate pyrovate transaminase (GPT) were elevated, while the activities of glutathione-s-transferase (GST) and superoxide dismutase (SOD) and the levels of reduced glutathione (GSH) were reduced in liver tissues in DMBA infused rats as compared to normal. Combined Supplementation of Soy and Garlic treatment altered the above mentioned biochemical parameters towards normal values. Present findings indicate that combined supplementation of soy and garlic got more marked effect on DMBA infused rats as compared to a group of rats received only garlic treatment.
Khataibeh
Moayad
M
Department of Medical Technology, Faculty of Allied Medical Sciences, Applied Sciences University, Amman, Jordan.
Abu-Alruz
Khalid
K
Al-Widyan
Omar
O
Abu-Samak
Mahmoud
M
Al-Qudah
Jafar
J
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity*; D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D002273:Carcinogens / Q000633:toxicity*; D019587:Dietary Supplements; D005260:Female; D005737:Garlic; D005982:Glutathione Transferase / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000378:metabolism*; D051381:Rats; D013025:Glycine max; D013482:Superoxide Dismutase / Q000378:metabolism
D002273:Carcinogens; D015127:9,10-Dimethyl-1,2-benzanthracene; D007770:L-Lactate Dehydrogenase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase