title: Design and synthesis of a G-protein-coupled receptor antagonist library of aryloxyalkanolamines using a polymer-supported acyclic acetal linker.
abstract: A G-Protein-coupled receptor-targeted library of aryloxypropanolamines and aryloxybutanolamines was efficiently executed using a novel, polymer-supported acyclic acetal linker, producing compounds in good yields and purities.
authors.affiliation: Bristol-Myers Squibb Company, R&D, Princeton, New Jersey 08543-4000, USA.
authors.forename: Jacques Y
authors.initials: JY
authors.lastname: Roberge
authors.forename: Lalgudi S
authors.initials: LS
authors.lastname: Harikrishnan
authors.forename: Muthoni G
authors.initials: MG
authors.lastname: Kamau
authors.forename: Zheming
authors.initials: Z
authors.lastname: Ruan
authors.forename: Katy
authors.initials: K
authors.lastname: Van Kirk
authors.forename: Yalei
authors.initials: Y
authors.lastname: Liu
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Cooper
authors.forename: Michael A
authors.initials: MA
authors.lastname: Poss
authors.forename: John K
authors.initials: JK
authors.lastname: Dickson
authors.forename: Ashvinikumar V
authors.initials: AV
authors.lastname: Gavai
authors.forename: Sam T
authors.initials: ST
authors.lastname: Chao
authors.forename: Leslie W
authors.initials: LW
authors.lastname: Leith
authors.forename: Mark S
authors.initials: MS
authors.lastname: Bednarz
authors.forename: Arvind
authors.initials: A
authors.lastname: Mathur
authors.forename: Ramesh
authors.initials: R
authors.lastname: Kakarla
authors.forename: Dora M
authors.initials: DM
authors.lastname: Schnur
authors.forename: Roy
authors.initials: R
authors.lastname: Vaz
authors.forename: R Michael
authors.initials: RM
authors.lastname: Lawrence
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000494:pharmacology; D020650:Combinatorial Chemistry Techniques; D003432:Cross-Linking Reagents; D015195:Drug Design; D006801:Humans; D011108:Polymers; D011412:Propanolamines; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors*; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000588:Amines; D003432:Cross-Linking Reagents; D011108:Polymers; D011412:Propanolamines; D043562:Receptors, G-Protein-Coupled; D054852:Small Molecule Libraries