title: Amelioration of airway stenosis in rabbit models by photodynamic therapy with talaporfin sodium (NPe6).
abstract: It is difficult to treat patients with acquired airway stenosis, and the quality of life of such patients is therefore lowered. We have suggested the application of photodynamic therapy (PDT) as a new treatment for airway stenosis and have determined the efficacy of PDT in animal disease models using a second-generation photosensitizer with reduced photosensitivity. An airway stenosis rabbit model induced by scraping of the tracheal mucosa was administered NPe6 (5 mg kg(-1)), and the stenotic lesion was irradiated with 670 nm light emitted from a cylindrical diffuser tip at 60 J cm(-2) under bronchoscopic monitoring. PDT using NPe6 improved airway stenosis (P = 0.043) and respiratory stridor. A significant prolongation of survival time was seen in the PDT-treated animals compared to that in the untreated animals (P = 0.025) and 44% of the treated animals achieved long-term survival (>60 days). In conclusion, PDT using NPe6 is effective for improvement in airway stenosis.
authors.affiliation: Department of Medical Engineering, National Defense Medical College, Tokorozawa, Saitama, Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Nakagishi
authors.forename: Noriko
authors.initials: N
authors.lastname: Morimoto
authors.forename: Masanori
authors.initials: M
authors.lastname: Fujita
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Ozeki
authors.forename: Tadaaki
authors.initials: T
authors.lastname: Maehara
authors.forename: Makoto
authors.initials: M
authors.lastname: Kikuchi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Morimoto
mesh_terms: D000818:Animals; D003251:Constriction, Pathologic / Q000188:drug therapy*; D004195:Disease Models, Animal; D008297:Male; D010778:Photochemotherapy; D011166:Porphyrins / Q000627:therapeutic use*; D011817:Rabbits; D014132:Trachea / Q000473:pathology*
chemical_list: D011166:Porphyrins; C053434:Talaporfin