title: The effect of some 1-[4-(2-diethylaminoethoxy)phenylcarbonyl]-3,5-bis (benzylidene)-4-piperidone methiodides and related compounds on respiration and swelling of rat liver mitochondria.
abstract: The effect of a number of N-aroyl-3,5-bis(benzylidene)-4-piperidones 2 and related quaternary ammonium compounds 3 on the rates of respiration in rat liver mitochondria were determined. All of the compounds stimulated respiration and the greatest effect was displayed by the compounds in series 3 which caused swelling of mitochondria.
authors.affiliation: College of Pharmacy and Nutrition, University of Saskatchewan, 110 Science Place, Saskatoon, Saskatchewan S7N 5C9, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Das
authors.forename: U
authors.initials: U
authors.lastname: Das
authors.forename: B
authors.initials: B
authors.lastname: Bandy
authors.forename: D K J
authors.initials: DK
authors.lastname: Gorecki
authors.forename: J R
authors.initials: JR
authors.lastname: Dimmock
mesh_terms: D000818:Animals; D007700:Kinetics; D051379:Mice; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000648:ultrastructure; D008933:Mitochondrial Swelling / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects*; D010881:Piperidones / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: C534380:1-(4-(2-diethylaminoethoxy)phenylcarbonyl)-3,5-bis (benzylidene)-4-piperidone; D010881:Piperidones