Chronic lymphocytic leukemia: "Cinderella" is becoming a star.
It has taken time for the status of chronic lymphocytic leukemia (CLL) to change within the scientific community. CLL, characterized by the accumulation of seemingly innocent long-lived monoclonal B cells exhibiting mature morphologies, has long been considered the "Cinderella" of blood cancers. CLL is receiving increasing attention from biologists and clinicians, however, because understanding of this disease may elucidate the association between lymphoid tumous and autoimmunity as well as help to define the relationships between antigen stimulation and malignant transformation.
Caligaris-Cappio
Federico
F
Department and Division of Oncology, University Scientific Institute San Raffaele, Milano, Italy. caligaris.federico@hsr.it
D000911:Antibodies, Monoclonal / Q000276:immunology; D000941:Antigens / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000473:pathology / Q000503:physiopathology
D000911:Antibodies, Monoclonal; D000941:Antigens; D001323:Autoantibodies