[Levitra (wardenafil) effects on endothelial function of brachial and cavernous arteries].
We studied effects of oral PDE-5 inhibitor wardenafil (levitra, Bayer & GlaxoSmithKline) on endothelial function of cavernous and brachial arteries in males with normal erectile function and in patients with erectile dysfunction (ED). Endothelial function of the brachial and cavernous arteries was studied in 75 males with ED and 20 healthy volunteers before and after wardenafil intake in a dose 20 mg using ultrasound examination of postcompression diameter changes. The results show that wardenafil improves endothelial function of cavernous and brachial arteries. The degree of the positive effect depends on baseline condition of the endothelial function of the vessels. The highest activity of the drug was seen in patients with arteriogenic ED who had significant decline of endothelial function of both cavernous and brachial arteries. The dependence of wardenafil effect on baseline condition of the endothelial function is confirmed by negative correlation between changes in postcompression artery dilatation after the drug intake and baseline values. This evidences for wardenafil ability to correct disturbed endothelial function of the arteries.
Mazo
E B
EB
Gamidov
S I
SI
Ovchinnikov
R I
RI
Adranovich
S V
SV
Iremashvili
V V
VV
D000328:Adult; D000368:Aged; D001916:Brachial Artery / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000378:metabolism*; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010410:Penile Erection / Q000187:drug effects; D058986:Phosphodiesterase 5 Inhibitors; D010726:Phosphodiesterase Inhibitors / Q000008:administration & dosage*; D010879:Piperazines / Q000008:administration & dosage*; D013450:Sulfones / Q000008:administration & dosage; D014227:Triazines / Q000008:administration & dosage; D000069058:Vardenafil Dihydrochloride
D007093:Imidazoles; D058986:Phosphodiesterase 5 Inhibitors; D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D013450:Sulfones; D014227:Triazines; D000069058:Vardenafil Dihydrochloride