title: Ser-His catalyses the formation of peptides and PNAs.
abstract: The dipeptide seryl-histidine (Ser-His) catalyses the condensation of esters of amino acids, peptide fragments, and peptide nucleic acid (PNA) building blocks, bringing to the formation of peptide bonds. Di-, tri- or tetra-peptides can be formed with yields that vary from 0.5% to 60% depending on the nature of the substrate and on the conditions. Other simpler peptides as Gly-Gly, or Gly-Gly-Gly are also effective, although less efficiently. We discuss the results from the viewpoint of primitive chemistry and the origin of long macromolecules by stepwise fragment condensations.
authors.affiliation: Biology Department, University of RomaTre, Rome, Italy.
authors.forename: Maçha
authors.initials: M
authors.lastname: Gorlero
authors.forename: Rafal
authors.initials: R
authors.lastname: Wieczorek
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Adamala
authors.forename: Alessandra
authors.initials: A
authors.lastname: Giorgi
authors.forename: Maria Eugenia
authors.initials: ME
authors.lastname: Schininà
authors.forename: Pasquale
authors.initials: P
authors.lastname: Stano
authors.forename: Pier Luigi
authors.initials: PL
authors.lastname: Luisi
mesh_terms: D002384:Catalysis; D004151:Dipeptides / Q000737:chemistry*; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis*; D010455:Peptides / Q000138:chemical synthesis*
chemical_list: D004151:Dipeptides; D020135:Peptide Nucleic Acids; D010455:Peptides; C422849:seryl-histidine