title: Sauroine, an alkaloid from Huperzia saururus with activity in wistar rats in electrophysiological and behavioral assays related to memory retention.
abstract: The present study describes the effects of sauroine (1), the main alkaloid obtained from Huperzia saururus, on memory retention and learning. To evaluate this, electrophysiological experiments and behavioral tests (step down) were performed on male Wistar rats. The results showed that 1 improved memory retention in the step-down test, significantly increasing hippocampal plasticity. Thus, 1 seems to be a constituent responsible for the activity claimed in folk medicine for H. saururus in Argentina.
authors.affiliation: Farmacognosia, Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Instituto Multidisciplinario de Biología Vegetal (IMBIV-CONICET), Edificio de Ciencias 2, Ciudad Universitaria, 5000 Córdoba, Argentina.
authors.forename: Mariana G
authors.initials: MG
authors.lastname: Vallejo
authors.forename: María G
authors.initials: MG
authors.lastname: Ortega
authors.forename: José L
authors.initials: JL
authors.lastname: Cabrera
authors.forename: Valeria P
authors.initials: VP
authors.lastname: Carlini
authors.forename: Susana Rubiales
authors.initials: SR
authors.lastname: de Barioglio
authors.forename: Romina S
authors.initials: RS
authors.lastname: Almirón
authors.forename: Oscar A
authors.initials: OA
authors.lastname: Ramírez
authors.forename: A Mariel
authors.initials: AM
authors.lastname: Agnese
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D001118:Argentina; D001519:Behavior / Q000187:drug effects*; D006624:Hippocampus / Q000187:drug effects; D032501:Huperzia / Q000737:chemistry*; D008297:Male; D008568:Memory / Q000187:drug effects*; D009043:Motor Activity / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000470:Alkaloids; C535132:sauroine