title: Outcomes of pregnancies complicated by beta-thalassemia/hemoglobin E disease.
abstract: OBJECTIVE
  To assess the outcomes of pregnancies affected by beta-thalassemia/hemoglobin E (beta-thal/HbE) disease.
  
  
  METHODS
  A retrospective cohort study was conducted with 54 women with singleton pregnancies complicated by beta-thal/HbE disease only. The controls-to-cases ratio was 2:1.
  
  
  RESULTS
  Although maternal outcomes were similar in both groups, gestational age at birth and birth weight were significantly lower in the study group and the cesarean delivery rate was significantly higher in that group (relative risk [RR], 2.1). The incidences of fetal growth restriction, preterm birth, and low birth weight were also significantly higher in the study group, with RRs of 2.8, 2.7, and 5.6, respectively.
  
  
  CONCLUSIONS
  Pregnancies affected by beta-thal/HbE disease were significantly associated with an increased risk of fetal growth restriction, preterm birth, and low birth weight.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Thailand.
authors.forename: Suchaya
authors.initials: S
authors.lastname: Luewan
authors.forename: Kasemsri
authors.initials: K
authors.lastname: Srisupundit
authors.forename: Theera
authors.initials: T
authors.lastname: Tongsong
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology* / Q000209:etiology; D006446:Hemoglobin E; D006801:Humans; D015994:Incidence; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000453:epidemiology*; D011256:Pregnancy Outcome / Q000453:epidemiology*; D018566:Pregnancy, High-Risk / Q000502:physiology; D047928:Premature Birth / Q000453:epidemiology* / Q000209:etiology; D012042:Registries; D012189:Retrospective Studies; D012306:Risk; D013785:Thailand / Q000453:epidemiology; D055815:Young Adult; D017086:beta-Thalassemia / Q000150:complications* / Q000453:epidemiology
chemical_list: D006446:Hemoglobin E