A case of tri-allelic pattern at locus D3S1358 on chromosome 3p21 inherited from paternal grandmother.
We are reporting a case of tri-allelic inheritance at locus D3S1358 commonly used for genetic identification in forensic DNA testing. This case was encountered during routine paternity testing using commercial DNA profiling kits. The tri-allelic inheritance identified was probably a result of duplication at this locus, supported by the equal peak intensities and inheritance pattern from grandparent to child.
Vidal
Christopher
C
MLS BioDNA Ltd, Kordin, Malta. chrisv@mlsbiodna.com
Cassar
Marisa
M
D000328:Adult; D002648:Child; D002874:Chromosome Mapping / Q000379:methods*; D002893:Chromosomes, Human, Pair 3; D016172:DNA Fingerprinting / Q000379:methods; D005190:Family; D005260:Female; D053803:Forensic Genetics / Q000379:methods; D005787:Gene Frequency / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D010290:Parents; D010375:Pedigree; D011110:Polymorphism, Genetic