title: Detection of integrated human papillomavirus by human papillomavirus types 16 and 18 in situ hybridization: a valuable diagnostic tool in diagnosing cervical carcinoma?
abstract: Human papillomavirus (HPV) infection is an important factor in cervical carcinogenesis. We describe 3 cases of patients with difficulties in diagnosing either a primary or recurrent cervical carcinoma. These cases illustrate that detection of integrated HPV is helpful in diagnosing cervical carcinoma.
authors.affiliation: Department of Obstetrics and Gynecology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
authors.forename: R J T
authors.initials: RJ
authors.lastname: van Golde
authors.forename: J A
authors.initials: JA
authors.lastname: de Hullu
authors.forename: R L M
authors.initials: RL
authors.lastname: Bekkers
authors.forename: J
authors.initials: J
authors.lastname: Bulten
authors.forename: J M M
authors.initials: JM
authors.lastname: Grefte
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000821:virology*; D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D015344:DNA Probes, HPV; D005260:Female; D005500:Follow-Up Studies; D052162:Human papillomavirus 16 / Q000302:isolation & purification*; D052161:Human papillomavirus 18 / Q000302:isolation & purification*; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization / Q000379:methods*; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000821:virology; D009367:Neoplasm Staging; D030361:Papillomavirus Infections / Q000175:diagnosis*; D011230:Precancerous Conditions / Q000473:pathology; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology / Q000821:virology; D018570:Risk Assessment; D012494:Sampling Studies; D012680:Sensitivity and Specificity; D014412:Tumor Virus Infections / Q000473:pathology / Q000821:virology; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000821:virology*; D055815:Young Adult
chemical_list: D015344:DNA Probes, HPV