title: Observational prospective study of the effectiveness in routine clinical practice of verteporfin photodynamic therapy in patients with neovascular age-related macular degeneration.
abstract: OBJECTIVE
  To investigate effectiveness in routine clinical practice of verteporfin photodynamic therapy (PDT) for neovascular age-related macular degeneration (nAMD).
  
  
  METHODS
  Patients commencing PDT for nAMD in a single UK centre entered a prospective observational 7-year study and were followed for 2 years. Best-corrected visual acuity (BCVA) and contrast sensitivity (CS) were measured at each visit by accredited technicians after full protocol refraction on standardised charts. Reasons for failure to complete the course of therapy were documented.
  
  
  RESULTS
  1008 patients entered the study between 1999 and 2006. 81% and 52% completed 12 and 24 months' follow-up respectively (excluding administrative censoring). Results at 12 and 24 months respectively were: maintenance of BCVA 62%, 63%; drop in mean BCVA (letters) 10.1, 9.4; numbers of treatments 2.9, 3.5. The mean CS remained stable. No correlation of change in BCVA outcome between first and second treated eyes in 82 bilateral cases was detected. Loss to follow-up was significantly associated with age, CS and distance from the treating centre.
  
  
  CONCLUSIONS
  PDT delivered in clinical practice is at least as effective as that reported in randomised clinical trials and uses fewer treatments.
authors.affiliation: Consultant Ophthalmic Surgeon, St Paul's Eye Unit, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK. s.p.harding@liverpool.ac.uk
authors.forename: S
authors.initials: S
authors.lastname: Murjaneh
authors.forename: M
authors.initials: M
authors.lastname: García-Fiñana
authors.forename: S
authors.initials: S
authors.lastname: Mahmood
authors.forename: P M
authors.initials: PM
authors.lastname: Lenfestey
authors.forename: S A
authors.initials: SA
authors.lastname: Taylor
authors.forename: I A
authors.initials: IA
authors.lastname: Pearce
authors.forename: M C
authors.initials: MC
authors.lastname: Briggs
authors.forename: H
authors.initials: H
authors.lastname: Heimann
authors.forename: S P
authors.initials: SP
authors.lastname: Harding
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020256:Choroidal Neovascularization / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D015350:Contrast Sensitivity / Q000187:drug effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008268:Macular Degeneration / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010352:Patient Dropouts; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use; D011166:Porphyrins / Q000627:therapeutic use; D011446:Prospective Studies; D016896:Treatment Outcome; D000077362:Verteporfin; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D017319:Photosensitizing Agents; D011166:Porphyrins; D000077362:Verteporfin