title: Novel species of human rhinoviruses in acute otitis media.
abstract: We have studied human rhinovirus (HRV) recovered from nasopharyngeal aspirates and middle ear fluids collected during acute otitis media with RT-PCR sequencing followed by phylogenetic analysis. In addition to a great diversity of traditional HRV types we found genetic relatives of the novel HRV species, suggested HRV-C, in both sample types. Our results indicate the presence of HRV-C in the middle ear for the first time.
authors.affiliation: From the *Enterovirus Laboratory, Department of Viral Diseases and Immunology, National Public Health Institute (KTL), Helsinki, Finland; and daggerDepartment of Vaccines, National Public Health Institute (KTL), Helsinki, Finland.
authors.forename: Carita
authors.initials: C
authors.lastname: Savolainen-Kopra
authors.forename: Soile
authors.initials: S
authors.lastname: Blomqvist
authors.forename: Terhi
authors.initials: T
authors.lastname: Kilpi
authors.forename: Merja
authors.initials: M
authors.lastname: Roivainen
authors.forename: Tapani
authors.initials: T
authors.lastname: Hovi
mesh_terms: D000208:Acute Disease; D036022:Capsid Proteins / Q000235:genetics; D004432:Ear, Middle / Q000382:microbiology; D006801:Humans; D007223:Infant; D009305:Nasopharynx / Q000382:microbiology; D010033:Otitis Media / Q000821:virology*; D010802:Phylogeny; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012229:Rhinovirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification
chemical_list: D036022:Capsid Proteins