title: Cervical intraepithelial neoplasia recurrence after conization in HIV-positive and HIV-negative women.
abstract: OBJECTIVE
  To evaluate the recurrence rates of cervical intraepithelial neoplasia (CIN) in a cohort of HIV-infected and noninfected women who underwent the loop electrosurgical excision procedure (LEEP).
  
  
  METHODS
  A prospective cohort study of 94 HIV-positive and 107 HIV-negative women, both with CIN, treated with LEEP. The diagnosis of recurrence was established after biopsy. The Kaplan-Meier method was used for survival analysis and multivariate analyses were carried out using the Cox proportional hazards regression model.
  
  
  RESULTS
  There was a predominance of low-grade lesions in HIV-positive compared with HIV-negative women (P<0.01). Recurrence was more frequent with compromised margins and glandular involvement (P<0.01). A multivariate analysis showed that HIV-infection, glandular involvement, and positive margins were independently associated with recurrence of lesions.
  
  
  CONCLUSIONS
  Recurrence rate of CIN in HIV-positive women was higher than in HIV-negative women. The factors associated with recurrence were HIV infection, glandular involvement, and positive margins.
authors.affiliation: Serviço de Referência de Patologia do Colo Uterino do PAM Sagrada Família, Department of Health Services, Belo Horizonte County, Brazil.
authors.forename: Maria Inês
authors.initials: MI
authors.lastname: Lima
authors.forename: Alexandre
authors.initials: A
authors.lastname: Tafuri
authors.forename: Angela C
authors.initials: AC
authors.lastname: Araújo
authors.forename: Luiza
authors.initials: L
authors.lastname: de Miranda Lima
authors.forename: Victor Hugo
authors.initials: VH
authors.lastname: Melo
mesh_terms: D000328:Adult; D002584:Cervix Uteri / Q000473:pathology*; D019092:Conization; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D011446:Prospective Studies; D012008:Recurrence; D002583:Uterine Cervical Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D002578:Uterine Cervical Dysplasia / Q000150:complications* / Q000473:pathology / Q000601:surgery