[Relationships between copy number variations and human disease and its perspective in animal disease-resistant breeding].
Copy number variations (CNVs) refer to the deletion, insertion, and duplication of genes over 1 kb in length. CNVs were widely found in human and other mammalian genomes. Here, we mainly reviewed the impacts of CNVs on the human diseases, and introduced the general detecting methods for CNVs. We also discussed the potential relationship between CNVs and disease-resistant breeding of animals. Because of the significant effects of CNVs on the resistance and susceptibility of disease, CNVs can be used in the marker-assisted selection, QTL fine mapping, and disease-resistant breeding of livestocks by means of biotechnologies.
He
Yang-Hua
YH
College of Animal Science and Technology, China Agricultural University, Beijing 100193, China. hyh19831205 @163.com
Yu
Ying
Y
Zhang
Yuan
Y
D000818:Animals; D001947:Breeding; D004194:Disease / Q000235:genetics*; D018628:Gene Dosage / Q000235:genetics*; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide