A straightforward synthesis of benzothiazines.
A series of 4H-3,1-benzothiazines have been successfully synthesized through a three-step sequence starting from commercially available 2-iodoaniline. The key step consists of the cyclization of compounds 6 via an intramolecular S-conjugate addition. The synthesis is straightforward, gives good yields and offers a broad range of possibilities since R can be many alkyl or aryl groups and Z a suitable electron-withdrawing functionalization.
Gimbert
Carolina
C
Department of Chemistry, Universitat Autonoma de Barcelona, Cerdanyola del Valles, 08193 Barcelona, Spain.
Vallribera
Adelina
A
D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry; D013843:Thiazines / Q000138:chemical synthesis* / Q000737:chemistry
D000577:Amides; D013843:Thiazines