Dicarboxylic acid esters as transdermal permeation enhancers: effects of chain number and geometric isomers.
A series of transdermal permeation enhancers based on dicarboxylic acid esters was studied. Single-chain amphiphiles were markedly more effective than the double-chain ones. Monododecyl maleate, that is a cis derivative, was a more potent enhancer than its trans isomer, while the activity of succinates strongly depended on the donor vehicle. No difference between diastereoisomeric tartaric and meso-tartaric acid derivatives was found.
Novotný
Michal
M
Centre for New Antivirals and Antineoplastics, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Heyrovského 1203, 50005 Hradec Králové, Czech Republic.
Hrabálek
Alexandr
A
Janůsová
Barbora
B
Novotný
Jakub
J
Vávrová
Katerina
K
D003998:Dicarboxylic Acids / Q000737:chemistry / Q000494:pharmacology*; D004952:Esters; D007536:Isomerism; D012869:Skin Absorption / Q000187:drug effects*
D003998:Dicarboxylic Acids; D004952:Esters