title: Pathotype and susceptibility profile of a community-acquired methicillin-resistant Staphylococcus aureus strain responsible for a case of severe pneumonia.
abstract: Recent articles have described an increasing number of infections due to Panton-Valentine leukocidin PVL-positive community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) worldwide. We report a case of necrotizing pneumonia successfully treated with levofloxacin in Italy, sustained by a PVL-positive CA-MRSA, belonging to ST88 and carrying a staphylococcal chromosomal cassette mec type V. Further molecular characterization of isolates revealed that they were PVL positive, belonged to the agr IV allele, possessed a capsular type 8, and had an almost complete pathotype composed of leukocidins and numerous adhesins. In addition, the strains were strong biofilm producers.
authors.affiliation: Department of Microbiology, University of Catania, 95124 Catania (I), Italy. stefanis@unict.it
authors.forename: Stefania
authors.initials: S
authors.lastname: Stefani
authors.forename: Dafne
authors.initials: D
authors.lastname: Bongiorno
authors.forename: Viviana
authors.initials: V
authors.lastname: Cafiso
authors.forename: Floriana
authors.initials: F
authors.lastname: Campanile
authors.forename: Massimo
authors.initials: M
authors.lastname: Crapis
authors.forename: Francesco
authors.initials: F
authors.lastname: Cristini
authors.forename: Assunta
authors.initials: A
authors.lastname: Sartor
authors.forename: Claudio
authors.initials: C
authors.lastname: Scarparo
authors.forename: Daniela
authors.initials: D
authors.lastname: Spina
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Viale
mesh_terms: D000328:Adult; D001426:Bacterial Proteins / Q000235:genetics; D001427:Bacterial Toxins / Q000235:genetics; D017714:Community-Acquired Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D017931:DNA Primers / Q000235:genetics; D005098:Exotoxins / Q000235:genetics; D006801:Humans; D007558:Italy; D007956:Leukocidins / Q000235:genetics; D064704:Levofloxacin; D008297:Male; D016106:Methicillin Resistance / Q000235:genetics*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000627:therapeutic use; D011023:Pneumonia, Staphylococcal / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D016133:Polymerase Chain Reaction; D012703:Serotyping
chemical_list: D001426:Bacterial Proteins; D001427:Bacterial Toxins; D017931:DNA Primers; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin; D064704:Levofloxacin; D015242:Ofloxacin