The overexpression of major antioxidant enzymes does not extend the lifespan of mice.
We evaluated the effect of overexpressing antioxidant enzymes on the lifespans of transgenic mice that overexpress copper zinc superoxide dismutase (CuZnSOD), catalase, or combinations of either CuZnSOD and catalase or CuZnSOD and manganese superoxide dismutase (MnSOD). Our results show that the overexpression of these major antioxidant enzymes, which are known to scavenge superoxide and hydrogen peroxide in the cytosolic and mitochondrial compartments, is insufficient to extend lifespan in mice.
Pérez
Viviana I
VI
Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, 78229, USA.
Van Remmen
Holly
H
Bokov
Alex
A
Epstein
Charles J
CJ
Vijg
Jan
J
Richardson
Arlan
A
D000818:Animals; D002374:Catalase / Q000096:biosynthesis* / Q000235:genetics; D004195:Disease Models, Animal; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D008136:Longevity / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D018384:Oxidative Stress; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013482:Superoxide Dismutase / Q000096:biosynthesis* / Q000235:genetics
D006861:Hydrogen Peroxide; D002374:Catalase; D013482:Superoxide Dismutase