Fullerene derivatized s-triazine analogues as antimicrobial agents.
A series of novel fullerene derivatives bearing s-triazine moiety have been synthesized by adopting 1,3 dipolar cycloaddition reaction of C(60) and azomethine ylides generated from the corresponding Schiff bases of 2,4,6 trisubstituted s-triazine. All the compounds synthesized were characterized by elemental analysis, FT-IR, (1)H NMR, (13)C NMR and FAB-MS. The compounds were then screened for their antibacterial activity against both gram-positive (Staphylococcus aureus, Bacillus subtilis, Bacillus pumilis) and gram-negative (Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae) bacteria by disc diffusion method. All the compounds were found to be active against these strains at very low concentration and were comparable to standard drug ciprofloxacin.
Kumar
Anish
A
Department of Chemistry, School of Sciences, Gujarat University, Navrangpura, Ahmedabad 380009, Gujarat, India.
Menon
Shobhana Karuveettil
SK
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D037741:Fullerenes / Q000737:chemistry / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D014227:Triazines / Q000737:chemistry* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D037741:Fullerenes; D014227:Triazines