Paget's Disease of Bone Complications and Treatment.
The severity of Paget's disease of bone is attributable to complications of the disease more than to the primary process. Some neurologic complications result from diversion of blood from nervous system toward active pagetic bone. Local compression of nerves also occurs but is less common. Cardiovascular complications are more rare. Orthopedic complications are dominated by neoplastic degeneration into osteosarcoma.Treatment of Paget's disease of bone is based on the use of antiosteoclastic drugs: bisphosphonates and calcitonin. Their efficacy is evident on the clinical and biological signs of Paget's disease. Bisphosphonates are well tolerated. The aim of the use of the newer-generation bisphosphonates is to normalize biochemical parameters to decrease the risk of occurrence of complications.
Alexandre
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Service Rhumatologie et LBTO and Université de St. Etienne, St. Etienne, France.