Lipid-lowering effects of time-released garlic powder tablets in double-blinded placebo-controlled randomized study.
OBJECTIVE
Clinical investigations of the effects of garlic preparations in hypercholesterolemia have demonstrated somewhat controversial results. These discrepancies may be due to the differences of the composition of garlic preparations and the biological response they may induce. The study was undertaken to test the hypothesis that garlic powder tablets with a prolonged mode of action promise potent biological effects.


METHODS
The lipid-lowering effects of time-released garlic powder tablets, Allicor (600 mg daily), were investigated in a double-blinded placebo-controlled randomized study in 42 men aged 35-70 with mild hypercholesterolemia.


RESULTS
Allicor treatment resulted in a moderate but statistically significant decrease in total cholesterol level that was observed after 8 and 12 weeks of active treatment. By the end of the study, total cholesterol in Allicor-treated patients had fallen by 7.6% (p=0.004) as compared to the level at randomization, and was 11.5% lower than the placebo group (p=0.005). LDL cholesterol in Allicor-treated patients fell by 11.8% (p=0.002) and 13.8% (p=0.009), respectively. HDL cholesterol also increased significantly after 8 and 12 weeks of treatment. By the end of the study, HDL cholesterol in Allicor-treated patients had increased by 11.5% (p=0.013).


CONCLUSIONS
The obtained results are in good agreement with trials that have demonstrated the cardioprotective action of garlic preparations and may be due to the use of a time-released form of garlic powder tablets that provides a prolonged biological effect.
Sobenin
Igor A
IA
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia.
Andrianova
Irina V
IV
Demidova
Olga N
ON
Gorchakova
Tatiana
T
Orekhov
Alexander N
AN
D000328:Adult; D000368:Aged; D008076:Cholesterol, HDL / Q000378:metabolism; D004311:Double-Blind Method; D005737:Garlic / Q000378:metabolism*; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy*; D008055:Lipids / Q000097:blood / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D010919:Placebos; D010936:Plant Extracts / Q000627:therapeutic use*; D011208:Powders; D013607:Tablets; D016896:Treatment Outcome
D008076:Cholesterol, HDL; D008055:Lipids; D010919:Placebos; D010936:Plant Extracts; D011208:Powders; D013607:Tablets