A cautionary note on the evaluation of genetic evidence from uniparentally transmitted markers.
The combination of the information obtained from lineage genetic markers, such as mitochondrial DNA (mtDNA) and the non-homologous region of Y-chromosome, with data resulting from meiotically recombining loci (diploid/autosomal or haplodiploid/X chromosome) into a single likelihood ratio has been recently proposed. In this work we challenge this proposal and demonstrate that while the genetic evidence obtained from loci which reshuffle at meiosis is appropriate for individual probability calculations, mtDNA and Y-chromosome data are not and, consequently, that joining the evidential value of the two types of markers is generally inconsistent and should be avoided. The assumption of non-involvement of relatives must be clearly and explicitly stated and its acceptance must be left to the court decision.
Amorim
António
A
IPATIMUP, Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Portugal. aamorim@ipatimup.pt
D041321:Chromosomes, Human, X; D041322:Chromosomes, Human, Y; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D053803:Forensic Genetics / Q000592:standards*; D005819:Genetic Markers / Q000235:genetics*; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D009154:Mutation; D010290:Parents; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011995:Recombination, Genetic; D015203:Reproducibility of Results
D004272:DNA, Mitochondrial; D005819:Genetic Markers