Elaborate treatment of retention in chemoselective chromatography--the retention increment approach and non-linear effects.
The retention increment approach is described which quantifies the association equilibria of a selectand and a selector in complexation and inclusion chromatography. A thermodynamic treatment of enantioselectivity based on retention phenomena in chromatography including entropy/enthalpy compensation and the isoenantioselective temperature is advanced. Kinetic parameters of enantiomerization are discussed. Non-linear effects, both existent and elusive, are described and proposed, respectively. The enantioselectivity pertaining to catalysis vs. chromatography is compared and a unified nomenclature is proposed. Through an educational effort, this account is aimed at providing a deeper insight into chemoselective aspects of chromatography thereby stimulating further research of both established and speculative phenomena of the most intriguing manifestation of chemoselectivity, that is, of enantioselectivity.
Schurig
Volker
V
Institute of Organic Chemistry, University of Tübingen, 72076 Tübingen, Germany. volker.schurig@uni-tuebingen.de
D002845:Chromatography / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D017711:Nonlinear Dynamics; D013237:Stereoisomerism; D013696:Temperature