title: Asthma and pulmonary function abnormalities in heterozygotes for cystic fibrosis transmembrane regulator gene mutations.
abstract: The aim of our study is to evaluate the association between CFTR gene mutations with asthma and pulmonary function abnormalities. For this purpose, 214 mutation carriers were compared to 185 non-carriers. Although the relative risk of asthma did not differ between groups (OR=0.61, 95% CI: 0.23-1.61, p=0.32), the values of FEV1, and FEV1/FVC ratio were lower in carriers (p=0.001, and p<0.001, respectively). This may imply that heterozygosity may be related with a silent obstructive pulmonary profile.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Douros
authors.forename: Ioanna
authors.initials: I
authors.lastname: Loukou
authors.forename: Stavros
authors.initials: S
authors.lastname: Doudounakis
authors.forename: Maria
authors.initials: M
authors.lastname: Tzetis
authors.forename: Kostas N
authors.initials: KN
authors.lastname: Priftis
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Kanavakis