Is controlling phosphorus by decreasing dietary protein intake beneficial or harmful in persons with chronic kidney disease?
BACKGROUND
Dietary restrictions to control serum phosphorus, which are routinely recommended to persons with chronic kidney disease, are usually associated with a reduction in protein intake. This may lead to protein-energy wasting and poor survival.


OBJECTIVE
We aimed to ascertain whether a decline in serum phosphorus and a concomitant decline in protein intake are associated with an increase in the risk of death.


METHODS
In a 3-y study (7/2001-6/2004) of 30 075 prevalent maintenance hemodialysis (MHD) patients, we examined changes in serum phosphorus and in normalized protein nitrogen appearance (nPNA), a surrogate of dietary protein intake, during the first 6 mo and the subsequent mortality. Four groups of MHD patients were defined on the basis of the direction of the changes in serum phosphorus and nPNA.


RESULTS
Baseline phosphorus had a J-shaped association with mortality, whereas higher baseline nPNA was linearly associated with greater survival. Compared with MHD patients whose serum phosphorus and nPNA both rose over 6 mo, those whose serum phosphorus decreased but whose nPNA increased had greater survival, with a case mix-adjusted death risk ratio of 0.90 (95% confidence limits: 0.86, 0.95; P < 0.001), whereas those whose phosphorus increased but whose nPNA decreased or those whose phosphorus and nPNA both decreased had worse mortality with a risk ratio of 1.11 (1.05,1.17; P < 0.001) and 1.06 (1.01,1.12; P = 0.02), respectively.


CONCLUSIONS
The risk of controlling serum phosphorus by restricting dietary protein intake may outweigh the benefit of controlled phosphorus and may lead to greater mortality. Additional studies including randomized controlled trials should examine whether nondietary control of phosphorus or restriction of nonprotein sources of phosphorus is safer and more effective.
Shinaberger
Christian S
CS
Harold Simmons Center for Kidney Disease Research and Epidemiology, Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90509-2910, USA.
Greenland
Sander
S
Kopple
Joel D
JD
Van Wyck
David
D
Mehrotra
Rajnish
R
Kovesdy
Csaba P
CP
Kalantar-Zadeh
Kamyar
K
D000704:Analysis of Variance; D015331:Cohort Studies; D004044:Dietary Proteins / Q000008:administration & dosage* / Q000009:adverse effects / Q000378:metabolism; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications / Q000401:mortality* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009584:Nitrogen / Q000032:analysis / Q000378:metabolism; D009752:Nutritional Status; D010758:Phosphorus / Q000097:blood*; D016226:Phosphorus, Dietary / Q000008:administration & dosage*; D011379:Prognosis; D011502:Protein-Energy Malnutrition / Q000453:epidemiology / Q000209:etiology / Q000401:mortality*; D006435:Renal Dialysis; D012307:Risk Factors; D016019:Survival Analysis; D016896:Treatment Outcome
D004044:Dietary Proteins; D016226:Phosphorus, Dietary; D010758:Phosphorus; D009584:Nitrogen