title: Evolution of tertiary carbinamine BACE-1 inhibitors: Abeta reduction in rhesus CSF upon oral dosing.
authors.affiliation: Department of Medicinal Chemistry, Merck Research Laboratories, P.O Box 4, WP14-3, West Point, PA 19486, USA. philippe_nantermet@merck.com
authors.forename: Philippe G
authors.initials: PG
authors.lastname: Nantermet
authors.forename: Hemaka A
authors.initials: HA
authors.lastname: Rajapakse
authors.forename: Mathew G
authors.initials: MG
authors.lastname: Stanton
authors.forename: Shaun R
authors.initials: SR
authors.lastname: Stauffer
authors.forename: James C
authors.initials: JC
authors.lastname: Barrow
authors.forename: Allison R
authors.initials: AR
authors.lastname: Gregro
authors.forename: Keith P
authors.initials: KP
authors.lastname: Moore
authors.forename: Melissa A
authors.initials: MA
authors.lastname: Steinbeiser
authors.forename: John
authors.initials: J
authors.lastname: Swestock
authors.forename: Harold G
authors.initials: HG
authors.lastname: Selnick
authors.forename: Samuel L
authors.initials: SL
authors.lastname: Graham
authors.forename: Georgia B
authors.initials: GB
authors.lastname: McGaughey
authors.forename: Dennis
authors.initials: D
authors.lastname: Colussi
authors.forename: Ming-Tain
authors.initials: MT
authors.lastname: Lai
authors.forename: Sethu
authors.initials: S
authors.lastname: Sankaranarayanan
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Simon
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Munshi
authors.forename: Jacquelynn J
authors.initials: JJ
authors.lastname: Cook
authors.forename: Marie A
authors.initials: MA
authors.lastname: Holahan
authors.forename: Maria S
authors.initials: MS
authors.lastname: Michener
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Vacca
mesh_terms: D000284:Administration, Oral; D000588:Amines / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology; D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D000818:Animals; D001812:Blood-Brain Barrier; D018360:Crystallography, X-Ray; D000882:Haplorhini; D020128:Inhibitory Concentration 50; D008253:Macaca mulatta; D008968:Molecular Conformation; D010446:Peptide Fragments / Q000134:cerebrospinal fluid*; D011480:Protease Inhibitors / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000588:Amines; D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; D011480:Protease Inhibitors; C538897:amyloid beta-protein (40-42); D053829:Amyloid Precursor Protein Secretases