title: [Pharmaceutical characteristics of brucine stealth liposomes].
abstract: OBJECTIVE
  To prepare brucine stealth liposomes and compare the in vitro characteristics with brucine conventional liposomes.
  
  
  METHODS
  Brucine stealth liposomes and conventional liposomes were both prepared by ammonium sulfate transmembrane gradients. The encapsulation efficiency, particle size, in vitro release profiles and stability were compared respectively.
  
  
  RESULTS
  The encapsulation efficiency of brucine stealth liposomes and conventional liposomes were (80.7 +/- 0.5)%, and (80.5 +/- 0.3)%, respectively. The mean paricle sizes were 103.5 nm and 169. 4 nm, respectively. Whether rat plasma was added or not, the release rate and degree of brucine stealth liposomes were significantly lower than those of conventional liposomes. Brucine stealth liposomes were more stable than conventional liposomes.
  
  
  CONCLUSIONS
  As the antitumor durg delivery system, the in vitro characteristics of brucine stealth liposomes are more satisfactory than the corresponding conventional liposomes.
authors.affiliation: College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210029, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Bao-chang
authors.initials: BC
authors.lastname: Cai
authors.forename: Wei
authors.initials: W
authors.lastname: Hu
authors.forename: Li-jie
authors.initials: LJ
authors.lastname: Wang
mesh_terms: D000818:Animals; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000493:pharmacokinetics; D008081:Liposomes / Q000737:chemistry* / Q000493:pharmacokinetics; D010316:Particle Size; D051381:Rats; D013331:Strychnine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D004365:Drugs, Chinese Herbal; D008081:Liposomes; C083806:brucine; D013331:Strychnine