title: Dietary patterns and health and nutrition outcomes in men living with HIV infection.
abstract: BACKGROUND
  Nutritional status is an important determinant of HIV outcomes.
  
  
  OBJECTIVE
  We assessed the association between dietary patterns identified by cluster analysis and change in body mass index (BMI; in kg/m(2)), CD4 count, and viral load (VL).
  
  
  METHODS
  HIV-positive adult male subjects (n = 348) with a BMI >or= 20.5 were evaluated by biochemical, body composition, and dietary data. Cluster analysis was performed on 41 designated food groups derived from 3-d food records. Dietary clusters were compared for sociodemographic, nutrient intake, and clinical outcomes. Multivariate linear regression assessed associations between dietary clusters and change in BMI, CD4 count, and VL.
  
  
  RESULTS
  We observed 3 dietary patterns: juice and soda; fast food and fruit drinks; and fruit, vegetable, and low-fat dairy. Subjects in the fast food and fruit drinks pattern had the lowest fiber intake, highest VL, and lowest CD4 count and had a lower income than did subjects in the other 2 clusters. Subjects in the fruit, vegetable, and low-fat dairy diet pattern had higher intakes of protein, fiber, and micronutrients and the highest BMI and CD4 count. Subjects in the juice and soda pattern had higher energy intakes and lowest BMI. On average, the fast food and fruit drinks cluster and fruit, vegetable, and low-fat dairy cluster gained 0.33 (P = 0.06) and 0.42 (P = 0.02), respectively, more in BMI than the juice and soda cluster across the study interval in a multivariate model.
  
  
  CONCLUSIONS
  In a cohort of HIV-positive men, we identified 3 distinct dietary patterns; each pattern was associated with specific nutrition, demographic, and HIV-related variables.
authors.affiliation: Department of Public Health and Family Medicine, School of Medicine, Tufts University, Boston, MA, USA. kristy.m.hendricks@dartmouth.edu
authors.forename: Kristy M
authors.initials: KM
authors.lastname: Hendricks
authors.forename: D Mkaya
authors.initials: DM
authors.lastname: Mwamburi
authors.forename: P K
authors.initials: PK
authors.lastname: Newby
authors.forename: Christine A
authors.initials: CA
authors.lastname: Wanke
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D015992:Body Mass Index; D018791:CD4 Lymphocyte Count; D016000:Cluster Analysis; D015331:Cohort Studies; D003611:Dairy Products; D004032:Diet / Q000523:psychology / Q000706:statistics & numerical data* / Q000639:trends; D004041:Dietary Fats / Q000008:administration & dosage; D005638:Fruit; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology / Q000401:mortality* / Q000473:pathology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009752:Nutritional Status; D011379:Prognosis; D014675:Vegetables; D019562:Viral Load
chemical_list: D004041:Dietary Fats