Altered pulmonary interleukin-6 signaling in preterm infants developing bronchopulmonary dysplasia.
Interleukin (IL)-6 signaling depends on the soluble IL-6 receptor (sIL-6R) and the soluble glycoprotein 130 (sgp130). To investigate the impact of IL-6 signaling on the pathogenesis of bronchopulmonary dysplasia of prematurity (BPD), IL-6, sIL-6R, and sgp130 were measured by enzyme-linked immunosorbent assay (ELISA) technique in tracheal aspirates of mechanically ventilated preterm infants. Infants developing BPD showed increased concentrations of IL-6, sIL-6R, and sgp-130 in their first week of life. These infants also had significantly higher molar ratios for IL-6/sIL-6R and IL-6/sgp130. The authors conclude that altered interleukin-6 signaling via the soluble receptors sIL-6R and sgp130 may play an important role in pulmonary inflammation of preterm infants.
von Bismarck
Philipp
P
Department of General Pediatrics, Universitatsklinikum Schleswig Holstein, Kiel, Germany. v.bismarck@pediatrics.uni-kiel.de
Claass
Andreas
A
Schickor
Carsten
C
Krause
Martin F
MF
Rose-John
Stefan
S
D001997:Bronchopulmonary Dysplasia / Q000276:immunology*; D002452:Cell Count; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007249:Inflammation / Q000209:etiology; D015850:Interleukin-6 / Q000032:analysis / Q000502:physiology*; D008297:Male; D009000:Monocytes / Q000502:physiology; D009504:Neutrophils / Q000502:physiology; D019947:Receptors, Interleukin-6 / Q000032:analysis; D015398:Signal Transduction; D014132:Trachea / Q000166:cytology / Q000276:immunology*
D015850:Interleukin-6; D019947:Receptors, Interleukin-6