JBIR-23 and -24, novel anticancer agents from Streptomyces sp. AK-AB27.
The screening for active compounds against malignant pleural mesothelioma (MPM) cells produced by Streptomyces sp. AK-AB27 resulted in the isolation of two compounds with a dodecahydrodibenzo[b,d]furan skeleton named JBIR-23 (1) and -24 (2). Their structures were established on the basis of extensive NMR and MS analyses. Compounds 1 and 2 exhibited cytotoxic effects against several MPM cell lines.
Motohashi
Keiichiro
K
Biomedicinal Information Research Center, Japan Biological Informatics Consortium, 2-42 Aomi, Koto-ku, Tokyo 135-0064, Japan.
Hwang
Ji-Hwan
JH
Sekido
Yoshitaka
Y
Takagi
Motoki
M
Shin-ya
Kazuo
K
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology* / Q000627:therapeutic use; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008654:Mesothelioma / Q000188:drug therapy; D013302:Streptomyces / Q000737:chemistry* / Q000145:classification
D000970:Antineoplastic Agents; D001572:Benzofurans; C538842:JBIR-23; C538843:JBIR-24