title: Synthesis of enamides via Rh/C-catalyzed direct hydroacylation of ketoximes.
abstract: Enamides were efficiently prepared via a novel Rh/C-catalyzed direct hydroacylation of ketoximes. Up to 88% isolated yield of enamides were obtained with this method. Subsequent asymmetric hydrogenation of the enamides with Rh/DuanPhos complex gave the corresponding chiral amine in excellent enantioselectivities (up to 99.7% ee).
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China.
authors.forename: Zheng-Hui
authors.initials: ZH
authors.lastname: Guan
authors.forename: Kexuan
authors.initials: K
authors.lastname: Huang
authors.forename: Shichao
authors.initials: S
authors.lastname: Yu
authors.forename: Xumu
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000215:Acylation; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D010091:Oximes / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013696:Temperature
chemical_list: D000588:Amines; D010091:Oximes; D002244:Carbon; D012238:Rhodium