title: Antimitotic activity of two macrocyclic bis(bibenzyls), isoplagiochins A and B from the Liverwort Plagiochila fruticosa.
abstract: Two bis(bibenzyls), isoplagiochins A (1) and B (2) have been isolated by the guidance of inhibitory effect of tubulin polymerization from the liverwort Plagiochila fruticosa (Plagiochilaceae). Isoplagiochins A and B inhibited the polymerization of tubulin at IC(50) 50 and 25muM, respectively. Furthermore structure-activity relationship based on their conformations was discussed. The presence of two aromatic rings which can be connected through two atoms bridge spacer of double bond may serve to maintain the backbone conformation.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan. moritah@hoshi.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Tomizawa
authors.forename: Tomoe
authors.initials: T
authors.lastname: Tsuchiya
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hirasawa
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Asakawa
mesh_terms: D035926:Hepatophyta / Q000737:chemistry*; D006860:Hydrogen Bonding; D047028:Macrocyclic Compounds / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008938:Mitosis / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D047028:Macrocyclic Compounds; C538707:isoplagiochin A; C538708:isoplagiochin B