title: [High expression of proteasome subunit PSMA7 in colorectal cancer is significantly correlated with liver metastasis].
abstract: OBJECTIVE
  To investigate the correlation between the proteasome subunit PSMA7 expression in colorectal cancer and its role in liver metastasis.
  
  
  METHODS
  To identify the PSMA7 protein expression in 62 primary site colorectal cancers, 34 lymph node metastatic sites and 13 liver metastatic sites by immunohistochemistry and clarify the correlation of its expression with the clinicopathological parameters.
  
  
  RESULTS
  High expression of PSMA7 was detected in 38.7% (24/62) of primary site colorectal cancer, 52.9% (18/34) of lymph node metastatic sites and 100% (13/13) liver metastatic sites but not in the normal colorectal tissue. High expression of PSMA7 was significantly correlated with liver metastasis (P = 0.028). The survival rate was significantly lower in patients with high expression of PSMA7 than in those with low expression of PSMA7 (P = 0.0008). As well, in multivariate analysis, PSMA7 expression demonstrated to be an independent prognostic factor (P = 0.004, relative risk 5.057; 95% confidence interval, 1.682-15.201).
  
  
  CONCLUSIONS
  PSMA7 may play an important role in the colorectal cancer progression. Evaluation of PSMA7 expression in primary colorectal cancer at the time of surgery might be a valuable test in defining patients with a high risk of developing liver metastasis.
authors.affiliation: Biomedical Research Center, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China.
authors.forename: Xiao-Tong
authors.initials: XT
authors.lastname: Hu
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Da
authors.initials: D
authors.lastname: Wang
authors.forename: Qing-Lan
authors.initials: QL
authors.lastname: Shi
authors.forename: Fu-Biao
authors.initials: FB
authors.lastname: Zhang
authors.forename: Yong-Qiang
authors.initials: YQ
authors.lastname: Liao
authors.forename: Mei
authors.initials: M
authors.lastname: Jin
authors.forename: Chao
authors.initials: C
authors.lastname: He
mesh_terms: D000328:Adult; D000368:Aged; D003110:Colonic Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008113:Liver Neoplasms / Q000201:enzymology / Q000556:secondary*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D012004:Rectal Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D015996:Survival Rate; D055815:Young Adult
chemical_list: C488662:PSMA7 protein, human; D046988:Proteasome Endopeptidase Complex