title: A feasibility trial of computer-aided diagnosis for enteric lesions in capsule endoscopy.
abstract: OBJECTIVE
  To investigate and evaluate the feasibility of the computer-aided screening diagnosis for enteric lesions in the capsule endoscopy (CE).
  
  
  METHODS
  After developing a series of algorithms for the screening diagnosis of the enteric lesions in CE based on their characteristic colors and contours, the normal and abnormal images obtained from 289 patients were respectively scanned and diagnosed by the CE readers and by the computer-aided screening for the enteric lesions with the image-processed software (IPS). The enteric lesions shown by the images included esoenteritis, mucosal ulcer and erosion, bleeding, space-occupying lesions, angioectasia, diverticula, parasites, etc. The images for the lesions or the suspected lesions confirmed by the CE readers and the computers were collected, and the effectiveness rate of the screening and the number of the scanned images were evaluated, respectively.
  
  
  RESULTS
  Compared with the diagnostic results obtained by the CE readers, the total effectiveness rate (sensitivity) in the screening of the commonly-encountered enteric lesions by IPS varied from 42.9% to 91.2%, with a median of 74.2%, though the specificity and the accuracy rates were still low, and the images for the rarely-encountered lesions were difficult to differentiate from the normal images. However, the number of the images screened by IPS was 5000 on average, and only 10%-15% of the original images were left behind. As a result, a large number of normal images were excluded, and the reading time decreased from 5 h to 1 h on average.
  
  
  CONCLUSIONS
  Though the total accuracy and specificity rates by the computer-aided screening for the enteric lesions with IPS are much lower than those by the CE readers, the computer-aided screening diagnosis can exclude a large number of the normal images and confine the enteric lesions to 5000 images on average, which can reduce the workload of the readers in the scanning of the images. This computer-aided screening technique can make a correct diagnosis as efficiently as possible in most of the patients.
authors.affiliation: Digestive Endoscopic Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China. gantao123@yahoo.com.cn
authors.forename: Tao
authors.initials: T
authors.lastname: Gan
authors.forename: Jun-Chao
authors.initials: JC
authors.lastname: Wu
authors.forename: Ni-Ni
authors.initials: NN
authors.lastname: Rao
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.forename: Bing
authors.initials: B
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D053704:Capsule Endoscopy / Q000379:methods*; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D005240:Feasibility Studies; D005767:Gastrointestinal Diseases / Q000175:diagnosis* / Q000473:pathology*; D006801:Humans; D008403:Mass Screening; D008875:Middle Aged; D012680:Sensitivity and Specificity; D055815:Young Adult