[Angiogenesis: the renal cancer model].
VHL gene inactivation, involved in the majority of metastatic non inherited renal carcinoma, I responsible of HIF accumulation. HIF leads to the activation of numerous genes including VEGF and PDGF. VEGF binds to his receptors present on endothelial cells to promote tumoral angiogenesis. Targeted therapy inhibit tumoral blood vessels growth and involves probably others complex mechanisms.
Méjean
A
A
Service d'Urologie, Université Paris Descartes, France. arnaud.mejean@nck.aphp.fr
Lebret
T
T
D002292:Carcinoma, Renal Cell / Q000098:blood supply* / Q000209:etiology; D006801:Humans; D007680:Kidney Neoplasms / Q000098:blood supply* / Q000209:etiology; D008954:Models, Biological; D009389:Neovascularization, Pathologic; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology
D042461:Vascular Endothelial Growth Factor A