Calciphylaxis: a case report.
Calciphylaxis or calcific uremic arteriolopathy is characterized by the involvement of the tunica elastica of the reticular or deep subcutaneous dermis, with extravascular and vascular thrombosis calcifications that lead to tissular ischemia. The torso muscles, the lumbar region, and lower limbs are more frequently affected. The pathogenesis is unknown. Calciphylaxis is associated to hyperparathyroidism, chronic renal failure, and diabetes mellitus. The best therapy to date is prevention: early treatment of renal failure, performing a partial parathyroidectomy where necessary, surgical debridement of the necrotic tissue, as well as avoiding the trigger factors such as systemic corticosteroids.
Strippoli
D
D
Department of Dermatology, Alessandro Manzoni Hospital, Lecco, Italy.
Simonetti
V
V
Russo
G
G
Motolese
A
A
D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000925:Anticoagulants / Q000627:therapeutic use; D001706:Biopsy; D002115:Calciphylaxis / Q000097:blood / Q000209:etiology* / Q000382:microbiology / Q000473:pathology / Q000628:therapy; D002118:Calcium / Q000097:blood; D003131:Combined Modality Therapy; D003646:Debridement; D017809:Fatal Outcome; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008297:Male; D054843:Negative-Pressure Wound Therapy; D010281:Parathyroid Hormone / Q000097:blood; D010758:Phosphorus / Q000097:blood; D006435:Renal Dialysis; D018805:Sepsis / Q000209:etiology; D012883:Skin Ulcer / Q000097:blood / Q000209:etiology* / Q000382:microbiology / Q000473:pathology / Q000628:therapy; D013524:Surgical Flaps / Q000009:adverse effects
D000900:Anti-Bacterial Agents; D000925:Anticoagulants; D010281:Parathyroid Hormone; D010758:Phosphorus; D002118:Calcium