Diagnosis and Treatment of Chronic Immune-mediated Neuropathies.
The chronic autoimmune neuropathies are a diverse group of disorders, whose diagnosis and classification is based on the clinical presentations and results of ancillary tests. In chronic inflammatory demyelinating polyneuropathy, controlled therapeutic trials demonstrated efficacy for intravenous gamma-globulins, corticosteroids, and plasmaphereis. In multifocal motor neuropathy, intravenous gamma-globulins have been shown to be effective. In the other immune-mediated neuropathies, there are no reported controlled therapeutic trials, but efficacy has been reported for some treatments in non-controlled trials on case studies. Choice of therapy in individual cases is based on reported efficacy, as well as severity, progression, coexisting illness, predisposition to developing complications, and potential drug interactions.
Latov
Norman
N
Weill Medical College of Cornell University, NY
Gorson
Kenneth C
KC
Brannagan
Thomas H
TH
Freeman
Roy L
RL
Apostolski
Slobodan
S
Berger
Alan R
AR
Bradley
Walter G
WG
Briani
Chiara
C
Bril
Vera
V
Busis
Neil A
NA
Cros
Didier P
DP
Dalakas
Marinos C
MC
Donofrio
Peter D
PD
Dyck
P James B
PJ
England
John D
JD
Fisher
Morris A
MA
Herrmann
David N
DN
Menkes
Daniel L
DL
Sahenk
Zarife
Z
Sander
Howard W
HW
Triggs
William J
WJ
Vallat
Jean Michel
JM