Rapid three-step one-pot microwave-assisted synthesis of 2,5-dioxo-1,2,5,6,7,8-hexahydro-3-quinolinecarbonitrile library.
Many well-known drugs contain 2-pyridone and 2-quinolone scaffolds. In the current paper, a one-pot three-step microwave-assisted method for the synthesis of N1-substituted 2,5-dioxo-1,2,5,6,7,8-hexahydro-3-quinolinecarbonitrile derivatives was developed. Employing this protocol, we quickly generated 105 compounds library from 1,3-cyclohexanediones, dimethylformamide dimethylacetal, and various cyanacetamides.
Yermolayev
Sergey A
SA
Department of Chemistry of Heterocyclic Compounds, SSI Institute for Single Crystals of National Academy of Sciences of Ukraine, Kharkiv, Ukraine.
Gorobets
Nikolay Yu
NY
Desenko
Sergey M
SM
D000081:Acetamides / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D003512:Cyclohexanones / Q000737:chemistry; D004126:Dimethylformamide / Q000737:chemistry; D008872:Microwaves; D009570:Nitriles / Q000138:chemical synthesis*; D011804:Quinolines / Q000138:chemical synthesis*; D054852:Small Molecule Libraries / Q000138:chemical synthesis*
D000081:Acetamides; D003512:Cyclohexanones; D009570:Nitriles; D011804:Quinolines; D054852:Small Molecule Libraries; C004636:1,3-cyclohexanedione; D004126:Dimethylformamide; C030686:acetamide