title: The effect of palmitic acid on spatial learning and extinction in adult male rat.
abstract: The aim of the present study is for evaluating the effect of different doses of palmitic acid on spatial learning in T-maze. So, Wister adult male rats were used in five groups and considered 10 rats for each group. The first group as a control group was fed with ordinary diet. Four groups were fed with a diet containing palmitic acid (10%) for 1, 2, 3 and 4 weeks, then rats were trained for spatial learning task by using T-maze at subsequently 9 days based on standard method. The result showed that, spatial learning increased by diet containing palmitic acid 10% for 1, 2 and 3 weeks were significant (p<0.05). However, dietary palmitic acid effect on learning because palmitic acid via palmitoylation modifies numerous important neuronal protein including GAP-43, NMDA receptor, AMPA receptor and these receptors are critical role in learning.
authors.affiliation: Department of Biology, Shahid Chamran University, Ahwaz, Iran.
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Hosseinzadeh
authors.forename: Ahmad Ali
authors.initials: AA
authors.lastname: Moazedi
authors.forename: Rahim
authors.initials: R
authors.lastname: Chinipardaz
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D005108:Extinction, Psychological / Q000187:drug effects*; D007858:Learning / Q000187:drug effects*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D019308:Palmitic Acid / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D012201:Reward; D013028:Space Perception / Q000187:drug effects*
chemical_list: D019308:Palmitic Acid