title: Statistical interpretation of CA125 and Bcl-2 in serum of patients with late stage ovarian cancer.
abstract: OBJECTIVE
  The present study was conducted to investigate the sensitivity, specificity, predictive values and accuracy of serum CA125 and Bcl-2 levels and their combination in advanced epithelial ovarian cancer patients.
  
  
  METHODS
  Healthy controls (n = 117) with no gynecologic problems and patients with ovarian carcinoma (n = 117), pathologically verified, consecutively admitted to the Istanbul University, Oncology Institute during a one-year period were investigated. Serum Bcl-2 and CA125 were determined by using enzyme linked immunosorbent assay method.
  
  
  RESULTS
  The serum bcl-2 and CA125 levels were significantly higher in patients with ovarian cancer than in the control group (P < 0.001). The diagnostic sensitivity and specificity, predictive values and accuracies were calculated for each marker and their combination.
  
  
  CONCLUSIONS
  The best result was achieved with the combination of CA125-bcl-2. This combination fulfills the need of diagnosis of ovarian carcinoma for the best sensitivity and specificity.
authors.affiliation: Department of Preventive Oncology, Biostatistics and Epidemiology, Institute of Oncology, University of Istanbul, Istanbul, Turkey. hcamlica@istanbul.edu.tr
authors.forename: Hakan
authors.initials: H
authors.lastname: Camlica
authors.forename: Derya
authors.initials: D
authors.lastname: Duranyildiz
authors.forename: Faruk
authors.initials: F
authors.lastname: Tas
authors.forename: Vildan
authors.initials: V
authors.lastname: Yasasever
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D018394:CA-125 Antigen / Q000097:blood*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000097:blood* / Q000175:diagnosis; D010051:Ovarian Neoplasms / Q000097:blood* / Q000175:diagnosis; D011379:Prognosis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000097:blood*; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D019253:Proto-Oncogene Proteins c-bcl-2