title: Long-term behavioral characterization of a rat model of intracerebral hemorrhage.
abstract: We tested the behavioral effects of intracerebral hemorrhage (ICH) in adult male rats. ICH was induced by collagenase injection into the basal ganglia and the rats were subjected to a longitudinal behavioral test battery. Both learning and memory deficits were detected shortly after injury. Two months after injury, there were still significant short- and long-term memory deficits. Rotarod testing also revealed long-term sensorimotor coordination deficits. No differences in activity levels were detected at any time. Thus, spontaneous ICH produced detectable cognitive and motor deficits that evolved over the course of 2 months. Along with histological analysis of infarct volume, this characterization provides a suitable baseline for the analysis of therapeutic interventions.
authors.affiliation: Department of Psychology, Loma Linda University, 11130 Anderson St. 119, Loma Linda, CA 92354, USA. behavioralneuroscience@gmail.com
authors.forename: R E
authors.initials: RE
authors.lastname: Hartman
authors.forename: H
authors.initials: H
authors.lastname: Rojas
authors.forename: J
authors.initials: J
authors.lastname: Tang
authors.forename: J
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D002543:Cerebral Hemorrhage / Q000139:chemically induced / Q000503:physiopathology*; D017364:Collagenases / Q000494:pharmacology; D004195:Disease Models, Animal; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D011597:Psychomotor Performance / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D017364:Collagenases