[Comparison between transabdominal and transcervical chorionic villus sampling in clinical application for prenatal diagnosis].
OBJECTIVE
To compare transabdominal and transcervical chorionic villus sampling (TC-CVS) in application for prenatal diagnosis, and to summarize the experience of transabdominal chorionic villus sampling (TA-CVS).


METHODS
One hundred and nine TA-CVS between April 2005 and November 2007 and 69 TC-CVS between August 1999 and March 2005 were retrospectively analyzed.


RESULTS
(1) The mean gestational age was (12.4 +/- 1.9) weeks at TA-CVS and (8.8 +/- 1.2) weeks at TC-CVS (P < 0.01). (2) Compared with TC-CVS, punctures were fewer (1.4 +/- 0.5) and (1.1 +/- 0.4) and specimen amount was more (9 +/- 5) mg and (17 +/- 5) mg in TA-CVS, and the success rate of one puncture (62.3% vs 87.2%) was higher in TA-CVS. (3) Among the cases followed up, the incidence of vaginal bleeding (TA-CVS: 2 cases, 2.0%; TC-CVS: 2 cases, 6.1%) and spontaneous abortion (TA-CVS: 4 cases, 4.0%; TC-CVS: 1 cases, 3.0%) were not significantly different between the two groups (P > 0.05).


CONCLUSIONS
TA-CVS appears to be a good method for early prenatal diagnosis with a wide range of indications, high success rate and sufficient specimen.
Luo
Yan-Min
YM
Fetal Medicine Center, Department of Obstetrics and Gynecology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China.
Fang
Qun
Q
Yang
Yong-Zhong
YZ
Chen
Jun-Hong
JH
Chen
Min-Ling
ML
Chen
Yong-Zhen
YZ
D000005:Abdomen; D000022:Abortion, Spontaneous / Q000453:epidemiology / Q000209:etiology; D000328:Adult; D001707:Biopsy, Needle / Q000379:methods; D002584:Cervix Uteri; D015193:Chorionic Villi Sampling / Q000009:adverse effects / Q000379:methods*; D000013:Congenital Abnormalities / Q000175:diagnosis; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis; D005865:Gestational Age; D006801:Humans; D007621:Karyotyping; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011272:Pregnancy, Multiple; D011296:Prenatal Diagnosis / Q000379:methods*; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal; D014592:Uterine Hemorrhage / Q000453:epidemiology / Q000209:etiology; D055815:Young Adult