title: Treatment and prevention of herpes labialis.
abstract: OBJECTIVE
  To review the evidence regarding the treatment and prevention of herpes labialis.
  
  
  METHODS
  The evidence relating to treatment and prevention of herpes labialis is derived from randomized controlled trials (level I evidence).
  
  
  RESULTS
  Treatment with an indifferent cream (zinc oxide or zinc sulfate), an anesthetic cream, or an antiviral cream has a small favourable effect on the duration of symptoms, if applied promptly. This is also the case with oral antiviral medication. If antiviral medicine (cream or oral) is started before exposure to the triggering factor (sunlight), it will provide some protection. Research on sunscreens has shown mixed results: some protection has been reported under experimental conditions that could not be replicated under natural conditions. In the long term, the number of relapses of herpes labialis can be limited with oral antiviral medication.
  
  
  CONCLUSIONS
  Only prompt topical or oral therapy will alleviate symptoms of herpes labialis. Both topical and oral treatment can contribute to the prevention of herpes labialis.
authors.affiliation: Dutch College of General Practitioners, Utrecht, The Netherlands. W.Opstelten@nhg.org
authors.forename: Wim
authors.initials: W
authors.lastname: Opstelten
authors.forename: Arie Knuistingh
authors.initials: AK
authors.lastname: Neven
authors.forename: Just
authors.initials: J
authors.lastname: Eekhof
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004333:Drug Administration Routes; D006560:Herpes Labialis / Q000188:drug therapy* / Q000517:prevention & control; D006801:Humans; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents