title: Role of advanced MR imaging modalities in diagnosing cerebral gliomas.
abstract: The objective of this study was to evaluate the potential role of newly developed, advanced magnetic resonance (MR) imaging techniques (spectroscopy, diffusion and perfusion imaging) in diagnosing brain gliomas, with special reference to histological typing and grading, treatment planning and posttreatment follow-up. Conventional MR imaging enables the detection and localisation of neoplastic lesions, as well as providing, in typical cases, some indication about their nature. However, it has limited sensitivity and specificity in evaluating histological type and grade, delineating margins and differentiating oedema, tumour and treatment side-effects. These limitations can be overcome by supplementing the morphological data obtained with conventional MR imaging with the metabolic, structural and perfusional information provided by new MR techniques that are increasingly becoming an integral part of routine MR studies. Incorporation of such new MR techniques can lead to more comprehensive and precise diagnoses that can better assist surgeons in determining prognosis and planning treatment strategies. In addition, the recent development of new, more effective, treatments for cerebral glioma strongly relies on morphofunctional MR imaging with its ability to provide a biological interpretation of these characteristically heterogeneous tumours.
authors.affiliation: U.O. di Neuroradiologia, AUSL BAT, Ospedale Lorenzo Bonomo, Andria, Italy. tscarabino@hotmail.com
authors.forename: T
authors.initials: T
authors.lastname: Scarabino
authors.forename: T
authors.initials: T
authors.lastname: Popolizio
authors.forename: F
authors.initials: F
authors.lastname: Trojsi
authors.forename: G
authors.initials: G
authors.lastname: Giannatempo
authors.forename: S
authors.initials: S
authors.lastname: Pollice
authors.forename: N
authors.initials: N
authors.lastname: Maggialetti
authors.forename: A
authors.initials: A
authors.lastname: Carriero
authors.forename: A
authors.initials: A
authors.lastname: Di Costanzo
authors.forename: G
authors.initials: G
authors.lastname: Tedeschi
authors.forename: U
authors.initials: U
authors.lastname: Salvolini
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis*; D038524:Diffusion Magnetic Resonance Imaging; D005500:Follow-Up Studies; D005910:Glioma / Q000175:diagnosis*; D006801:Humans; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D010347:Patient Care Planning; D012680:Sensitivity and Specificity