title: Continued complete remission without systemic therapy for isolated testicular relapse after bone marrow transplantation in a boy with acute lymphoblastic leukemia.
abstract: ITR after BMT in cases of acute lymphoblastic leukemia is relatively rare. Treatment for ITR after BMT generally consists of a combination of local irradiation, orchiectomy, and systemic chemotherapy. However, the effectiveness of these modalities has not been established. Both irradiation and systemic chemotherapy including a second transplantation would result in additional toxicity. In this report we describe a boy with ITR 91 months after BMT who has remained in complete remission more than two yr after a unilateral orchiectomy. We did not treat this patient with systemic chemotherapy, as his ITR developed very late. Our experience suggests that orchiectomy alone is a reasonable option for very late ITR after BMT.
authors.affiliation: Department of Pediatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. yuichik@m.kufm.kagoshima-u.ac.jp
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kodama
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Okamoto
authors.forename: Osamu
authors.initials: O
authors.lastname: Ijichi
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Shinkoda
authors.forename: Takuro
authors.initials: T
authors.lastname: Nishikawa
authors.forename: Takayuki
authors.initials: T
authors.lastname: Tanabe
authors.forename: Takako
authors.initials: T
authors.lastname: Yoshioka
authors.forename: Yukie
authors.initials: Y
authors.lastname: Tashiro
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Mougi
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Kawano
mesh_terms: D016026:Bone Marrow Transplantation / Q000379:methods*; D002648:Child; D006801:Humans; D007223:Infant; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D012008:Recurrence; D012074:Remission Induction; D013736:Testicular Neoplasms / Q000175:diagnosis* / Q000556:secondary; D013737:Testis / Q000601:surgery; D016896:Treatment Outcome