title: Ratcheting Myc.
abstract: In this issue of Cancer Cell, Murphy et al. describe a mouse model designed to examine the biological effects of different levels of deregulated c-myc expression. They provide evidence that distinct threshold levels of Myc are required for increased proliferation and for apoptosis in different tissues.
authors.affiliation: Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.
authors.forename: Brian W
authors.initials: BW
authors.lastname: Freie
authors.forename: Robert N
authors.initials: RN
authors.lastname: Eisenman
mesh_terms: D000818:Animals; D017209:Apoptosis; D049109:Cell Proliferation; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051379:Mice; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism* / Q000628:therapy; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D016271:Proto-Oncogene Proteins c-myc; D014157:Transcription Factors