title: Six cases of Aerococcus sanguinicola infection: clinical relevance and bacterial identification.
abstract: Aerococcus sanguinicola is a Gram-positive coccus first described in 2001. Infections in humans are rare but the use of 16S rRNA gene sequencing and improved phenotypic methods has facilitated the identification of A. sanguinicola. We report here 6 cases of A. sanguinicola bacteraemia, 2 of which were associated with infective endocarditis. Most patients were elderly (median age 70 y) and had underlying neurological disorders including dementia, cerebral degeneration, and myelomeningocele. The primary focus of infection was the urinary tract in 3 cases and the gallbladder in 1; no focus was detected in 2 cases. Long-term prognosis was poor reflecting the frailty of the patients. All strains were susceptible to penicillin, ampicillin, cefuroxime, vancomycin, erythromycin, and rifampicin. The optimal treatment of infection with A. sanguinicola has yet to be determined.
authors.affiliation: Department of Bacteriology, Mycology and Parasitology, Statens Serum Institute, Copenhagen, Denmark. Kristinaibler@hotmail.com
authors.forename: Kristina
authors.initials: K
authors.lastname: Ibler
authors.forename: Kjeld
authors.initials: K
authors.lastname: Truberg Jensen
authors.forename: Christian
authors.initials: C
authors.lastname: Ostergaard
authors.forename: Ute Wolff
authors.initials: UW
authors.lastname: Sönksen
authors.forename: Brita
authors.initials: B
authors.lastname: Bruun
authors.forename: Henrik C
authors.initials: HC
authors.lastname: Schønheyder
authors.forename: Michael
authors.initials: M
authors.lastname: Kemp
authors.forename: Rimtas
authors.initials: R
authors.lastname: Dargis
authors.forename: Keld
authors.initials: K
authors.lastname: Andresen
authors.forename: Jens Jørgen
authors.initials: JJ
authors.lastname: Christensen
mesh_terms: D000328:Adult; D000368:Aged; D016470:Bacteremia / Q000382:microbiology / Q000503:physiopathology; D003718:Denmark / Q000453:epidemiology; D004697:Endocarditis, Bacterial / Q000382:microbiology; D005260:Female; D005705:Gallbladder Diseases / Q000382:microbiology; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D017422:Sequence Analysis, DNA; D013289:Streptococcaceae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity; D014552:Urinary Tract Infections / Q000382:microbiology
chemical_list: D012336:RNA, Ribosomal, 16S