title: [A new case of systemic contact eczema to nickel in a peripheral venous catheter].
abstract: BACKGROUND
  Nickel-elicited systemic contact dermatitis is a rare event seen in previously skin sensitized patients. We report a case of systemic contact dermatitis due to nickel released into the bloodstream from a metal section of a catheter during infusion.
  
  
  METHODS
  A 39-year-old woman presented papular and vesicular flexural dermatitis and pompholyx 72h after cervical spine surgery. She received numerous treatments during the perioperative period. A challenge test with one of the suspected treatments, cefazolin, was performed by intravenous infusion over a six-hour period using the same Optiva) peripheral catheter (Johnson & Johnson, USA). Six hours after withdrawal of the catheter, an eruption occurred. A further cefazolin challenge test performed later under identical conditions but using a different type of catheter (nickel-free) was negative. Nickel-elicited systemic contact dermatitis due to nickel release from a catheter was diagnosed. The patient's medical history was notable for contact dermatitis with jewellery. Patch tests confirmed marked nickel sensitization.
  
  
  CONCLUSIONS
  A little-known way of systemic nickel absorption is through insertion of a venous catheter with a metal section containing nickel and a metallic eyelet containing nickel can in fact remain in place after catheter placement. Nickel can thus be released into the circulation during infusion and an eruption may occur during the postoperative period. This diagnosis is noteworthy as such eruptions can easily be mistakenly diagnosed as cutaneous drug eruptions.
authors.affiliation: Service de dermato-allergologie, hôpital Saint-Eloi, université Montpellier I, CHU de Montpellier, 80, avenue Augustin-Fliche, 34295 Montpellier cedex 5, France. n-raison@chu-montpellier.fr
authors.forename: N
authors.initials: N
authors.lastname: Raison-Peyron
authors.forename: N
authors.initials: N
authors.lastname: Kluger
authors.forename: O
authors.initials: O
authors.lastname: Guillard
authors.forename: P
authors.initials: P
authors.lastname: Demoly
authors.forename: P
authors.initials: P
authors.lastname: Colson
authors.forename: B
authors.initials: B
authors.lastname: Guillot
mesh_terms: D000328:Adult; D002406:Catheterization, Peripheral / Q000009:adverse effects* / Q000295:instrumentation; D002437:Cefazolin / Q000008:administration & dosage; D002574:Cervical Vertebrae / Q000473:pathology / Q000601:surgery; D003877:Dermatitis, Contact / Q000209:etiology* / Q000473:pathology; D004485:Eczema / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D055498:Jewelry / Q000009:adverse effects; D008487:Medical History Taking; D009532:Nickel / Q000633:toxicity*; D012279:Rickets / Q000601:surgery
chemical_list: D009532:Nickel; D002437:Cefazolin