Colocalization of 5-HT1F receptor and glutamate in neurons of the vestibular nuclei in rats.
Interplay between migraine and balance disorder morbidities has been a topic of interest for many years. Serotonin (5-HT) receptor is closely related with migraine and is associated with vestibular symptoms. The mechanism underlying migrainous vertigo, however, has not been determined. 5-HT1F receptor has recently attracted attention in the treatment of migraine, and the release of glutamate from trigeminal neurons has been implicated in migraine. In this study, the authors observed the colocalization of 5-HT1F receptor and glutamate in the vestibular nuclei of rats using double immunofluorescence, which suggests that 5-HT1F receptor might modulate glutamate release from the vestibular nuclei. The results of this study suggest that 5-HT1F receptor agonists represent a potential therapeutic strategy for migraine and balance disorders by blocking the release of glutamate.
Ahn
Seong-Ki
SK
Department of Otolaryngology bInstitute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju, South Korea. skahn@gnu.ac.kr
Khalmuratova
Roza
R
Jeon
Sea-Yuong
SY
Kim
Jin-Pyeong
JP
Park
Jung-Je
JJ
Hur
Dong-Gu
DG
Kim
Dae-Woo
DW
Balaban
Carey D
CD
D000818:Animals; D005455:Fluorescent Antibody Technique; D018698:Glutamic Acid / Q000378:metabolism*; D008297:Male; D009474:Neurons / Q000378:metabolism*; D010784:Photomicrography; D051381:Rats; D020318:Rats, Long-Evans; D011985:Receptors, Serotonin / Q000378:metabolism*; D014726:Vestibular Nuclei / Q000378:metabolism / Q000502:physiology*; D003689:Vestibular Nucleus, Lateral / Q000378:metabolism; D000096642:Receptor, Serotonin, 5-HT1F
D018698:Glutamic Acid; D011985:Receptors, Serotonin; D000096642:Receptor, Serotonin, 5-HT1F