title: Differences in serum phospholipid fatty acid compositions and estimated desaturase activities between Japanese men with and without metabolic syndrome.
abstract: OBJECTIVE
  This study was designed to clarify differences in serum phospholipid fatty acid compositions and estimated desaturase activities between Japanese men with and without metabolic syndrome (MetS).
  
  
  METHODS
  From among 227 males, 40 to 59 years of age, excluding those receiving treatment for lipid disorders, 165 subjects (including 27 with MetS) were selected for this study. Serum phospholipid fatty acid compositions were determined, and desaturase activities were estimated.
  
  
  RESULTS
  The C15:0 and C17:0 fatty acids associated with hepatic function were lower, while the C20:3n-6 and C20:4n-3 fatty acids were higher, in subjects with than without MetS (p<0.05). The estimated desaturase activity for D5D(n-6) was lower in subjects with than without MetS (p<0.01). Body fat percentage was an independent negative predictor of C17:0, and a positive predictor of log C20:3n-6 and log C20:4n-3 (p<0.01). HDL-C was an independent negative predictor of log C15:0 and of C17:0 (p<0.01).
  
  
  CONCLUSIONS
  Decreases in minor saturated fatty acids, accumulation of C20:3n-6 and C20:4n-3 and low estimated D5D activity were confirmed to be associated with MetS.
authors.affiliation: Department of Food and Nutrition, Faculty of Home Economics, Japan Women's University, Tokyo, Japan. maruyama@fc.jwu.ac.jp
authors.forename: Chizuko
authors.initials: C
authors.lastname: Maruyama
authors.forename: Megumi
authors.initials: M
authors.lastname: Yoneyama
authors.forename: Noriko
authors.initials: N
authors.lastname: Suyama
authors.forename: Kasuya
authors.initials: K
authors.lastname: Yoshimi
authors.forename: Ai
authors.initials: A
authors.lastname: Teramoto
authors.forename: Yuka
authors.initials: Y
authors.lastname: Sakaki
authors.forename: Yasuyo
authors.initials: Y
authors.lastname: Suto
authors.forename: Kei
authors.initials: K
authors.lastname: Takahashi
authors.forename: Risa
authors.initials: R
authors.lastname: Araki
authors.forename: Yuko
authors.initials: Y
authors.lastname: Ishizaka
authors.forename: Minoru
authors.initials: M
authors.lastname: Yamakado
authors.forename: Tamio
authors.initials: T
authors.lastname: Teramoto
mesh_terms: D000328:Adult; D000886:Anthropometry / Q000379:methods; D015992:Body Mass Index; D044943:Fatty Acid Desaturases / Q000378:metabolism*; D005227:Fatty Acids / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007564:Japan; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood; D008875:Middle Aged; D010743:Phospholipids / Q000378:metabolism*; D012044:Regression Analysis; D017962:alpha-Linolenic Acid / Q000378:metabolism
chemical_list: D005227:Fatty Acids; D010743:Phospholipids; D017962:alpha-Linolenic Acid; C117025:pentadecanoic acid; D044943:Fatty Acid Desaturases; C013102:margaric acid