title: Effects of a specially pulsed electric field on an animal model of wound healing.
abstract: The possible beneficial effects of a specially pulsed electric field (PEF) on wound healing were investigated in this study. We made a pair of triangular, full-thickness, dorsal incisions in the skin of 32 healthy male mice (one control group and three exposure groups). The treatment groups were kept between parallel plates in a partially insulated exposed environment. Group I was exposed to an electric field intensity of 10 kV/m, group II was exposed to 1.9 kV/m, and group III was exposed to 0.9 kV/m. PEFs were applied to the subjects for 20-22 h and 8 consecutive days. We determined the differences in wound recovery between the groups based on the following parameters: collagen fiber density, inflammatory infiltration density, capillary proliferation, and existence of exudates. We found that a 0.9 kV/m-1.9 kV/m chopped direct current (DC) electric field with a 30 micros repetition time favorably affected collagen synthesis and wound recovery. Despite the intensity of 0.9-1.9 kV/m, PEF accelerated healing, but 10 kV/m decelerated this recovery process.
authors.affiliation: Department of Biology, Suleyman Demirel University, Isparta, Turkey.
authors.forename: Kenan
authors.initials: K
authors.lastname: Cinar
authors.forename: Selcuk
authors.initials: S
authors.lastname: Comlekci
authors.forename: Nurgul
authors.initials: N
authors.lastname: Senol
mesh_terms: D000818:Animals; D002196:Capillaries / Q000254:growth & development; D003094:Collagen / Q000096:biosynthesis; D004599:Electric Stimulation Therapy / Q000379:methods*; D005122:Exudates and Transudates / Q000502:physiology; D007249:Inflammation / Q000473:pathology; D008297:Male; D051379:Mice; D023421:Models, Animal; D012867:Skin / Q000098:blood supply / Q000293:injuries / Q000473:pathology / Q000503:physiopathology; D014945:Wound Healing / Q000502:physiology*
chemical_list: D003094:Collagen