1H-MRSI of prostate cancer: the relationship between metabolite ratio and tumor proliferation.
OBJECTIVE
To investigate whether 1H-MRSI can be used to predict the proliferative activity of prostate cancer.


METHODS
Thirty-eight patients with prostate cancer (PCa) and thirty-three patients with benign prostate hyperplasia (BPH) were included in this study. Patients were examined in supine position using a 1.5T superconducting magnetic scanner equipped with a pelvic phased-array multi-coil and CSI-3D-PROSTATE sequence. Commercial software was used to acquire and process MR spectroscopic imaging data. Mean (Cho+Cr)/Cit ratios of PCa, BPH, and peripheral zone (PZ) were calculated. Cellularity of PCa was recorded based on hematoxylin and eosin staining. PCNA was detected using immunohistochemical techniques.


RESULTS
The mean (Cho+Cr)/Cit ratio of the peripheral zone (0.38+/-0.09) was lower than that of BPH (0.51+/-0.19) (P<0.05). The average value of (Cho+Cr)/Cit ratio of prostate cancer was 3.98+/-0.12. The (Cho+Cr)/Cit ratio of prostate cancer was higher than that of the peripheral zone and BPH (P<0.05). The cellularity and PCNA LI of prostate cancer were 12.90+/-4.07% and 72.1+/-19.01%, respectively. The (Cho+Cr)/Cit ratio of prostate cancer positively correlated with tumor cellularity (r=0.582, P=0.027) and PCNA LI (r=0.495, P=0.022).


CONCLUSIONS
The (Cho+Cr)/Cit ratio of PCa can reveal the differences in proliferative activity between PCa and BPH. MRSIs are therefore able to predict the proliferative rate of variously differentiated prostate cancers.
Wang
Xi Zhen
XZ
Shandong Medical Imaging Research Institute, Shandong University, 324# JingWu Road, Jinan 250021, PR China. zhen94320@yahoo.com.cn
Wang
Bin
B
Gao
Zhi Qin
ZQ
Liu
Jin Gang
JG
Liu
Zuo Qin
ZQ
Niu
Qing Liang
QL
Sun
Zhen Kui
ZK
Yuan
Yu Xiao
YX
D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D014408:Biomarkers, Tumor / Q000032:analysis*; D002794:Choline / Q000032:analysis*; D019343:Citric Acid / Q000032:analysis*; D003401:Creatine / Q000032:analysis*; D003936:Diagnosis, Computer-Assisted / Q000379:methods; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D011522:Protons; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic
D014408:Biomarkers, Tumor; D011522:Protons; D019343:Citric Acid; D003401:Creatine; D002794:Choline