title: ent-Kaurane diterpenoids from Isodon scoparius.
abstract: Nine new ent-kaurane diterpenoids, isoscoparins D-L (1-9), and an artificial product, the acetonide of rabdoloxin A (10), along with 16 known analogues (11-26), were isolated from the leaves of Isodon scoparius. The new structures were determined by 1D and 2D NMR spectroscopic analysis. Selected compounds were evaluated for their cytotoxicity against NB4, A549, PC-3, MCF-7, and SH-SY5Y cell lines.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhao
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Pu
authors.forename: Sheng-Xiong
authors.initials: SX
authors.lastname: Huang
authors.forename: Ying-Li
authors.initials: YL
authors.lastname: Wu
authors.forename: Li-Bin
authors.initials: LB
authors.lastname: Yang
authors.forename: Wei-Lie
authors.initials: WL
authors.lastname: Xiao
authors.forename: Quan-Bin
authors.initials: QB
authors.lastname: Han
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Chen
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D045786:Diterpenes, Kaurane; D004365:Drugs, Chinese Herbal