Does loss of CD151 expression promote the metastasis of hypoxic colon cancer cells?
Intratumoral hypoxia increases invasion and metastasis through multiple mechanisms, including changes in gene expression that are mediated by hypoxia-inducible factor 1. In hypoxic colon cancer cells, hypoxia-inducible factor 1 inhibits the expression of CD151, a cell surface molecule that normally tethers epithelial cells to the basement membrane, which may promote metastasis.
Semenza
Gregg L
GL
Vascular Program, Institute for Cell Engineering, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. gsemenza@jhmi.edu
D015703:Antigens, CD / Q000032:analysis*; D002448:Cell Adhesion; D015687:Cell Hypoxia; D003110:Colonic Neoplasms / Q000473:pathology*; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D060185:Tetraspanin 24
D015703:Antigens, CD; C554715:CD151 protein, human; D060185:Tetraspanin 24