title: Synthesis and conformational analysis of cyclic analogues of inverse gamma-turns.
abstract: Gamma-turn analogues comprising a modified dipeptide constrained in an eleven-membered ring were prepared by alkene metathesis and analysed by NMR and molecular modelling studies. The results reveal that some of the cyclic analogues form inverse gamma-turns and preferentially adopt conformations determined by the identity of the incorporated amino acid residues and the nature of the constraining linker (E/Z-alkene or alkane).
authors.affiliation: Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, UK OX1 3TA.
authors.forename: Morakot
authors.initials: M
authors.lastname: Kaewpet
authors.forename: Barbara
authors.initials: B
authors.lastname: Odell
authors.forename: Michael A
authors.initials: MA
authors.lastname: King
authors.forename: Biswadip
authors.initials: B
authors.lastname: Banerji
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Schofield
authors.forename: Timothy D W
authors.initials: TD
authors.lastname: Claridge
mesh_terms: D000475:Alkenes / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry; D004151:Dipeptides / Q000138:chemical synthesis / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D002264:Carboxylic Acids; D004151:Dipeptides; D010456:Peptides, Cyclic