title: Asystole due to trigemino-cardiac reflex: a rare complication of trans-sphenoidal surgery for pituitary adenoma.
abstract: The trigemino-cardiac reflex (TCR) is a well-known reflexive response in which bradycardia, hypotension, and gastric hypermotility are induced by stimulation of a peripheral or central portion of the trigeminal nerve. This reflex occurs during craniofacial surgery and other operations on or near the cerebellopontine angle, petrosal sinus, orbit and trigeminal ganglion. TCR is a well-known, although not well documented, phenomenon commonly observed during trans-sphenoidal surgery for resection of pituitary adenomas. We report a case in which asystole occurred during trans-sphenoidal surgery on a pituitary adenoma that was infiltrating the right cavernous sinus. When the anesthesiologist reported asystole, the team stopped manipulation and administered intravenous atropine. Intra-operative MRI showed a small tumour remnant in the right cavernous sinus. The operation was terminated but subsequent radiosurgery was planned for the residual tumor. Although TCR is rare and usually self-limiting, this case led us to change our treatment strategy. Surgeons who perform trans-sphenoidal surgery should be aware of this potential problem. Invasive pituitary adenomas should be removed gently and the risk of triggering TCR should be kept in mind.
authors.affiliation: Department of Neurosurgery, Acibadem Neurological Sciences Hospital, Kozyatagi, 34742, Istanbul, Turkey. askinseker@hotmail.com
authors.forename: Askin
authors.initials: A
authors.lastname: Seker
authors.forename: Zafer Orkun
authors.initials: ZO
authors.lastname: Toktas
authors.forename: Selcuk
authors.initials: S
authors.lastname: Peker
authors.forename: Halit Abbas
authors.initials: HA
authors.lastname: Batirel
authors.forename: M
authors.initials: M
authors.lastname: Necmettin Pamir
mesh_terms: D005260:Female; D006323:Heart Arrest / Q000209:etiology*; D006801:Humans; D007431:Intraoperative Complications; D055909:Magnetic Field Therapy / Q000379:methods; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000009:adverse effects*; D010911:Pituitary Neoplasms / Q000601:surgery*; D012018:Reflex / Q000502:physiology*; D013101:Sphenoid Sinus / Q000601:surgery*; D014276:Trigeminal Nerve / Q000502:physiology*