Influence of cyclic AMP on facial nerve regeneration in rats.
Promoting facial nerve regeneration is a significant challenge.


OBJECTIVE
To evaluate the possible neurotrophic influence of cyclic AMP on facial nerve regeneration of Wistar rats.


METHODS
The right facial nerve of thirty-two animals were completely transected and immediately sutured, followed by exposure or not to topical cyclic AMP. Behavioral and histometric analyses were done at 14 and 28 days.


RESULTS
Statistical differences (p<0.05) were found in the behavioral and histometric analyses on the 14th day, suggesting an early regenerative response of the facial nerve to cAMP exposure.


CONCLUSIONS
This study demonstrates a possible neurotrophic effect of cAMP on facial nerve regeneration in rats.
Borin
Andrei
A
Master's degree in otorhinolaryngology; doctoral student. Electronic address: andreiborin@hotmail.com.
Toledo
Ronaldo Nunes
RN
Biologist and doctorate in biochemistry; researcher at the Centro de Biotecnologia, Instituto Butantan.
Ho
Paulo Lee
PL
Doctorate in otorhinolaryngology, adjunct professor, otorhinolaryngology discipline, UNIFESP/EPM.
Testa
José Ricardo Gurgel
JRG
Livre-docente (habilitation) professor, affiliated professor, otorhinolaryngology discipline, UNIFESP/EPM.
Cruz
Oswaldo Laércio Mendonça
OLM
Livre-docente (habilitation) professor, otorhinolaryngology discipline, UNIFESP/EPM. Otorhinolaryngology and Head & Neck Department, Universidade Federal de Sao Paulo.
Fukuda
Yotaka
Y
Livre-docente (habilitation) professor, otorhinolaryngology discipline, UNIFESP/EPM. Otorhinolaryngology and Head & Neck Department, Universidade Federal de Sao Paulo.
D000287:Administration, Topical; D000704:Analysis of Variance; D000818:Animals; D000242:Cyclic AMP / Q000494:pharmacology*; D005154:Facial Nerve / Q000187:drug effects / Q000502:physiology*; D020220:Facial Nerve Injuries / Q000601:surgery*; D006801:Humans; D008297:Male; D023421:Models, Animal; D009414:Nerve Growth Factors / Q000502:physiology; D009416:Nerve Regeneration / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013536:Suture Techniques
D009414:Nerve Growth Factors; D000242:Cyclic AMP