[Oral antifungal agents].
The oral agents for deep-seated mycoses that can be used in Japan are amphotericin B, flucytosine, fluconazole, itraconazole, and voriconazole. There are many guidelines, for example, the Japanese "Guidelines for the Diagnosis and Treatment of Deep-Seated Mycosis 2007", IDSA guidelines for candidiasis, aspergillosis, and so on, and these agents are used in antifungal therapy while referring to these guidelines. Recently relation between serum concentration of antifungal agent with effectiveness or side effects is found gradually. After understanding not only character of antifungal agents, spectrum, side effects, and adjustment according to renal function and other drug, but also new agents and other findings, we should treat mycoses. Especially, in the diabetic, it is necessary to note the rise of the blood level of the calcium channel blocker and oral antidiabetic agents while being using these drugs together with triazoles.
Tarumoto
Norihito
N
Department of Infectious Disease and Infection Control, Saitama Medical University.
Maesaki
Shigefumi
S
D000284:Administration, Oral; D000666:Amphotericin B; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology; D048909:Diabetes Complications; D015725:Fluconazole; D005437:Flucytosine; D006801:Humans; D017964:Itraconazole; D007564:Japan; D009181:Mycoses / Q000188:drug therapy*; D017410:Practice Guidelines as Topic; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D017964:Itraconazole; D000666:Amphotericin B; D015725:Fluconazole; D005437:Flucytosine; D065819:Voriconazole