Inclusion body myositis: review of recent literature.
Inclusion body myositis (IBM) is a progressive inflammatory skeletal muscle disease of unknown cause and without effective treatment. This article discusses existing literature, emphasizing disease mechanisms and models. In particular, it addresses limitations in the beta-amyloid-mediated theory of IBM myofiber injury, flawed rationales of animal models of this disease, and recent reports regarding treatment.
Greenberg
Steven A
SA
Department of Neurology, Brigham and Women's Hospital,75 Francis Street, Boston, MA 02115, USA. sagreenberg@partners.org
D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism; D000818:Animals; D006801:Humans; D007107:Immune System / Q000502:physiology; D009124:Muscle Proteins / Q000235:genetics / Q000378:metabolism; D018979:Myositis, Inclusion Body / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D012196:Review Literature as Topic
D016564:Amyloid beta-Protein Precursor; D009124:Muscle Proteins