Stem cells in the trabecular meshwork: present and future promises.
Primary open-angle glaucoma is recognized as a disease of aging, and studies show a relationship between aging and trabecular meshwork (TM) cell density. Human TM cell division occurs primarily in the anterior, non-filtering region. A commonly used glaucoma treatment, laser trabeculoplasty (LTP), triggers and increases cell division, as well as cell migration of these anterior TM cells. These freshly-divided migrating cells repopulate the burned laser sites, suggesting that they are stem cells. Several studies concerning this putative TM stem cell will be discussed.
Kelley
M J
MJ
Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA. kelleyma@ohsu.edu
Rose
A Y
AY
Keller
K E
KE
Hessle
H
H
Samples
J R
JR
Acott
T S
TS
D005902:Glaucoma, Open-Angle / Q000473:pathology* / Q000601:surgery; D006801:Humans; D053685:Laser Therapy; D012038:Regeneration; D013234:Stem Cells / Q000473:pathology*; D014129:Trabecular Meshwork / Q000473:pathology* / Q000502:physiology; D014130:Trabeculectomy