Macromolecular delivery across the blood-brain barrier.
The delivery of macromolecules into the central nervous system (CNS) via the blood stream is seriously limited by the blood-brain barrier (BBB). Noninvasive, transient, and local image-guided blood-brain barrier disruption (BBBD) can be accomplished using focused ultrasound exposure with intravascular injection of pre-formed microbubbles. A detailed description of the method for MRI-guided focal BBBD in animals will be described in this chapter. The method may open a new era in CNS macromolecular drug delivery.
Hynynen
Kullervo
K
Department of Medical Biophysics, University of Toronto and Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON, Canada.
D000818:Animals; D001812:Blood-Brain Barrier; D002138:Calibration; D016503:Drug Delivery Systems; D046911:Macromolecular Substances / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008279:Magnetic Resonance Imaging; D011817:Rabbits
D046911:Macromolecular Substances