Plasma phospholipid fatty acid profiles and their association with food intakes: results from a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition.
BACKGROUND
Plasma phospholipid fatty acids have been correlated with food intakes in populations with homogeneous dietary patterns. However, few data are available on populations with heterogeneous dietary patterns.


OBJECTIVE
The objective was to investigate whether plasma phospholipid fatty acids are suitable biomarkers of dietary intakes across populations involved in a large European multicenter study.


METHODS
A cross-sectional study design nested to the European Prospective Investigation into Cancer and Nutrition (EPIC) was conducted to determine plasma fatty acid profiles in >3,000 subjects from 16 centers, who had also completed 24-h dietary recalls and dietary questionnaires. Plasma fatty acids were assessed by capillary gas chromatography. Ecological and individual correlations were calculated between fatty acids and select food groups.


RESULTS
The most important determinant of plasma fatty acids was region, which suggests that the variations across regions are largely due to different food intakes. Strong ecological correlations were observed between fish intake and long-chain n-3 polyunsaturated fatty acids (r = 0.78, P < 0.01), olive oil and oleic acid (r = 0.73, P < 0.01), and margarine and elaidic acid (r = 0.76, P < 0.01). Individual correlations varied across the regions, particularly between olive oil and oleic acid and between alcohol and the saturation index, as an indicator of stearoyl CoA desaturase activity.


CONCLUSIONS
These findings indicate that specific plasma phospholipid fatty acids are suitable biomarkers of some food intakes in the EPIC Study. Moreover, these findings suggest complex interactions between alcohol intake and fatty acid metabolism, which warrants further attention in epidemiologic studies relating dietary fatty acids to alcohol-related cancers and other chronic diseases.
Saadatian-Elahi
Mitra
M
International Agency for Research on Cancer, Lyon, France.
Slimani
Nadia
N
Chajès
Véronique
V
Jenab
Mazda
M
Goudable
Joëlle
J
Biessy
Carine
C
Ferrari
Pietro
P
Byrnes
Graham
G
Autier
Philippe
P
Peeters
Petra H M
PH
Ocké
Marga
M
Bueno de Mesquita
Bas
B
Johansson
Ingegerd
I
Hallmans
Göran
G
Manjer
Jonas
J
Wirfält
Elisabet
E
González
Carlos A
CA
Navarro
Carmen
C
Martinez
Carmen
C
Amiano
Pilar
P
Suárez
Laudina Rodriguez
LR
Ardanaz
Eva
E
Tjønneland
Anne
A
Halkjaer
Jytte
J
Overvad
Kim
K
Jakobsen
Marianne Uhre
MU
Berrino
Franco
F
Pala
Valeria
V
Palli
Domenico
D
Tumino
Rosario
R
Vineis
Paolo
P
Santucci de Magistris
Maria
M
Spencer
Elisabeth A
EA
Crowe
Francesca L
FL
Bingham
Sheila
S
Khaw
Kay-Tee
KT
Linseisen
Jakob
J
Rohrmann
Sabine
S
Boeing
Heiner
H
Noethlings
Ute
U
Olsen
Karina Standahl
KS
Skeie
Guri
G
Lund
Eiliv
E
Trichopoulou
Antonia
A
Oustoglou
Erifili
E
Clavel-Chapelon
Françoise
F
Riboli
Elio
E
D015415:Biomarkers / Q000097:blood; D002849:Chromatography, Gas; D003431:Cross-Cultural Comparison; D003430:Cross-Sectional Studies; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage* / Q000378:metabolism; D004044:Dietary Proteins / Q000008:administration & dosage; D005060:Europe; D005227:Fatty Acids / Q000032:analysis / Q000097:blood*; D005231:Fatty Acids, Unsaturated / Q000032:analysis / Q000097:blood*; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D008297:Male; D011939:Mental Recall; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology; D010743:Phospholipids / Q000032:analysis / Q000737:chemistry*; D011446:Prospective Studies; D012044:Regression Analysis; D012737:Sex Factors; D011795:Surveys and Questionnaires
D015415:Biomarkers; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D010743:Phospholipids