Association of IL6 and IL10 with renal dysfunction and the use of haemofiltration during cardiopulmonary bypass.
OBJECTIVE
Assessment of the effects of haemofiltration during cardiopulmonary bypass (CPB) in coronary artery bypass grafting (CABG) on the renal function and correlation with interleukin 6 (IL6) and interleukin 10 (IL10) levels.


METHODS
Seventy-nine patients scheduled for elective CABG were prospectively randomised into two groups. Group A with a haemofilter attached to arterial line of the CPB circuit and group B without a haemofilter. The two groups were comparable in their symptoms, sex, and previous history of myocardial infarction, left ventricular function, cross-clamp time, bypass time and total grafting per patients. Blood urea and creatinine levels were measured the day before operation, 12h after operation and on the 3rd postoperative day. IL6 and IL10 were measured in blood samples collected 1h before surgery, on arrival to ITU and after 12h. IL6 and IL10 levels were measured using ELISA test.


RESULTS
High levels of IL6 (>100 pg/ml) postoperatively were associated with increased incidence of renal dysfunction (p<0.017). Additionally, high IL10 (>30 pg/ml) levels postoperatively were associated with increased incidence of renal dysfunction (p<0.014). There were no effects of the haemofilter on postoperative IL6 and IL10 levels. Use of haemofiltration during CPB was found not to be protective against renal dysfunction (p<0.071).


CONCLUSIONS
Haemofilter use during cardiopulmonary bypass does not have a protective effect on postoperative kidney function. Haemofilter has no effect on the level of IL6 and IL10.
Musleh
Ghassan S
GS
Manchester Royal Infirmary, Manchester, UK. eindara@yahoo.com
Datta
Subir S
SS
Yonan
Nizar N
NN
Grotte
Geir J
GJ
Prendergast
Brian A
BA
Hasan
Ragheb I
RI
Deyrania
Abdul K
AK
D058186:Acute Kidney Injury / Q000209:etiology / Q000517:prevention & control; D000368:Aged; D002315:Cardiopulmonary Bypass / Q000009:adverse effects / Q000379:methods*; D001026:Coronary Artery Bypass / Q000009:adverse effects / Q000379:methods*; D003324:Coronary Artery Disease / Q000097:blood / Q000601:surgery; D003404:Creatinine / Q000097:blood; D005260:Female; D006440:Hemofiltration / Q000009:adverse effects* / Q000295:instrumentation; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D011183:Postoperative Complications
D015850:Interleukin-6; D016753:Interleukin-10; D003404:Creatinine