title: High-fructose corn syrup, energy intake, and appetite regulation.
abstract: High-fructose corn syrup (HFCS) has been implicated in excess weight gain through mechanisms seen in some acute feeding studies and by virtue of its abundance in the food supply during years of increasing obesity. Compared with pure glucose, fructose is thought to be associated with insufficient secretion of insulin and leptin and suppression of ghrelin. However, when HFCS is compared with sucrose, the more commonly consumed sweetener, such differences are not apparent, and appetite and energy intake do not differ in the short-term. Longer-term studies on connections between HFCS, potential mechanisms, and body weight have not been conducted. The main objective of this review was to examine collective data on associations between consumption of HFCS and energy balance, with particular focus on energy intake and its regulation.
authors.affiliation: Rippe Lifestyle Institute, Shrewsbury, MA 01545, USA.
authors.forename: Kathleen J
authors.initials: KJ
authors.lastname: Melanson
authors.forename: Theodore J
authors.initials: TJ
authors.lastname: Angelopoulos
authors.forename: Von
authors.initials: V
authors.lastname: Nguyen
authors.forename: Linda
authors.initials: L
authors.lastname: Zukley
authors.forename: Joshua
authors.initials: J
authors.lastname: Lowndes
authors.forename: James M
authors.initials: JM
authors.lastname: Rippe
mesh_terms: D001069:Appetite Regulation / Q000187:drug effects* / Q000502:physiology; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D002149:Energy Intake / Q000187:drug effects* / Q000502:physiology; D004734:Energy Metabolism / Q000187:drug effects / Q000502:physiology; D005632:Fructose / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D013549:Sweetening Agents / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D013549:Sweetening Agents; D005632:Fructose