Diverse regulatory mechanisms of eukaryotic transcriptional activation by the proteasome complex.
The life of any protein within a cell begins with transcriptional activation, and ends with proteolytic degradation. Intriguingly, the 26S proteasome complex, a non-lysosomal protein degradation machine comprising the 20S proteolytic core and 19S regulatory particles, has been implicated in intimate regulation of eukaryotic transcriptional activation through diverse mechanisms in a proteolysis-dependent as well as independent manner. Here, we discuss the intricate mechanisms of such proteasomal regulation of eukaryotic gene activation via multiple pathways.
Bhaumik
Sukesh R
SR
Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA. sbhaumik@siumed.edu
Malik
Shivani
S
D000818:Animals; D005057:Eukaryotic Cells / Q000378:metabolism*; D006801:Humans; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D015533:Transcriptional Activation
D046988:Proteasome Endopeptidase Complex