title: Septo-optic dysplasia and psychiatric disorders: a case report.
abstract: BACKGROUND
  Septo-optic dysplasia, a variable combination of abnormalities of cerebral midline structures, is a clinically heterogeneous syndrome in which the midline defects may be implicated in psychiatric disturbances.
  
  
  OBJECTIVE
  To describe a case of septo-optic dysplasia associated with depression and psychosis and to discuss the role of these developmental abnormalities in psychiatric disturbances.
  
  
  METHODS
  The patient's clinico-anamnestic, neuroradiologic, neuropsychiatric, endocrinologic, ophthalmologic, and genetic profile was evaluated.
  
  
  CONCLUSIONS
  Developmental abnormalities due to disruption of the complex neural network linking the septum pellucidum with other limbic structures may have been involved in the affective and psychotic disturbances observed in our patient.
authors.affiliation: Department of Behavioural Neurology, UCADH, Institute of Neurology IRCCS C. Mondino, University of Pavia, Italy. paola.bini@mondino.it
authors.forename: Paola
authors.initials: P
authors.lastname: Bini
authors.forename: Lorenza
authors.initials: L
authors.lastname: Montalbetti
authors.forename: Pietro
authors.initials: P
authors.lastname: Tosca
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Ratti
authors.forename: Carla
authors.initials: C
authors.lastname: Uggetti
authors.forename: Arrigo
authors.initials: A
authors.lastname: Moglia
authors.forename: Alfredo
authors.initials: A
authors.lastname: Costa
mesh_terms: D018692:Antimanic Agents / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001569:Benzodiazepines / Q000627:therapeutic use; D003866:Depressive Disorder / Q000150:complications / Q000188:drug therapy / Q000523:psychology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009483:Neuropsychological Tests; D000077152:Olanzapine; D011618:Psychotic Disorders / Q000150:complications / Q000188:drug therapy / Q000523:psychology*; D025962:Septo-Optic Dysplasia / Q000150:complications / Q000188:drug therapy / Q000523:psychology*; D014057:Tomography, X-Ray Computed; D014635:Valproic Acid / Q000627:therapeutic use; D014794:Visual Fields; D014888:Wechsler Scales
chemical_list: D018692:Antimanic Agents; D014150:Antipsychotic Agents; D001569:Benzodiazepines; D014635:Valproic Acid; D000077152:Olanzapine