Transient hyperphosphatasemia in an infant with bronchiolitis and pneumonia.
We present a case of benign transient hyperphosphatasemia in a 4-month-old infant with acute bronchiolitis and pneumonia. During hospitalization the infant had an increased catalytic activity of alkaline phosphatase (ALP): day 2, 5074 U/L; day 3, 5622-U/L; and day 8, 3129 U/L. The x-ray, leukocytosis, and C-reactive protein findings pointed to bacterial etiology of the respiratory disorder. Electrophoretic separation revealed an atypical isoenzyme profile: fast anodal, near-cathodal and bone fractions. ALP levels normalized within 54 days, and control electrophoresis indicated normal liver, placental/placental-like, intestinal and bone isoenzymes. The appearance of atypical fast anodal and near-cathodal fractions of ALP in this infant during the course of acute lower respiratory tract infection and rapid return to the reference intervals pointed to benign transient hyperphosphatasemia.
Dodig
Slavica
S
Srebrnjak Children's Hospital, Srebrnjak 100, HR-10000 Zagreb, Croatia. slavica.dodig@zg.t-com.hr
Demirovic
J
J
Jelcic
Z
Z
Richter
D
D
Cepelak
I
I
Zrinski Topic
R
R
Petrinovic
R
R
D000208:Acute Disease; D000469:Alkaline Phosphatase / Q000097:blood; D001988:Bronchiolitis / Q000150:complications*; D005260:Female; D006801:Humans; D054559:Hyperphosphatemia / Q000175:diagnosis* / Q000209:etiology*; D007223:Infant; D007527:Isoenzymes / Q000097:blood; D011014:Pneumonia / Q000150:complications*
D007527:Isoenzymes; D000469:Alkaline Phosphatase