Mitochondria-targeted antioxidants in the treatment of disease.
Mitochondrial oxidative damage is thought to contribute to a wide range of human diseases; therefore, the development of approaches to decrease this damage may have therapeutic potential. Mitochondria-targeted antioxidants that selectively block mitochondrial oxidative damage and prevent some types of cell death have been developed. These compounds contain antioxidant moieties, such as ubiquinone, tocopherol, or nitroxide, that are targeted to mitochondria by covalent attachment to a lipophilic triphenylphosphonium cation. Because of the large mitochondrial membrane potential, the cations are accumulated within the mitochondria inside cells. There, the conjugated antioxidant moiety protects mitochondria from oxidative damage. Here, we outline some of the work done to date on these compounds and how they may be developed as therapies.
Smith
Robin A J
RA
Department of Chemistry, University of Otago, Dunedin, New Zealand.
Adlam
Victoria J
VJ
Blaikie
Frances H
FH
Manas
Abdul-Rahman B
AR
Porteous
Carolyn M
CM
James
Andrew M
AM
Ross
Meredith F
MF
Logan
Angela
A
Cochemé
Helena M
HM
Trnka
Jan
J
Prime
Tracy A
TA
Abakumova
Irina
I
Jones
Bruce A
BA
Filipovska
Aleksandra
A
Murphy
Michael P
MP
D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D018384:Oxidative Stress
D000975:Antioxidants