title: CD8+ T-cells mediate immunopathology in tick-borne encephalitis.
abstract: Epidemics of tick-borne encephalitis involving thousands of humans occur annually in the forested regions of Europe and Asia. Despite the importance of this disease, the underlying basis for the development of encephalitis remains undefined. Here, we prove the key role of CD8(+) T-cells in the immunopathology of tick-borne encephalitis, as demonstrated by prolonged survival of SCID or CD8(-/-) mice, following infection, when compared with immunocompetent mice or mice with adoptively transferred CD8(+) T-cells. The results imply that tick-borne encephalitis is an immunopathological disease and that the inflammatory reaction significantly contributes to the fatal outcome of the infection.
authors.affiliation: Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, Ceské Budejovice, Czech Republic. ruzekd@paru.cas.cz
authors.forename: Daniel
authors.initials: D
authors.lastname: Růzek
authors.forename: Jirí
authors.initials: J
authors.lastname: Salát
authors.forename: Martin
authors.initials: M
authors.lastname: Palus
authors.forename: Tamara S
authors.initials: TS
authors.lastname: Gritsun
authors.forename: Ernest A
authors.initials: EA
authors.lastname: Gould
authors.forename: Iva
authors.initials: I
authors.lastname: Dyková
authors.forename: Anna
authors.initials: A
authors.lastname: Skallová
authors.forename: Jirí
authors.initials: J
authors.lastname: Jelínek
authors.forename: Jan
authors.initials: J
authors.lastname: Kopecký
authors.forename: Libor
authors.initials: L
authors.lastname: Grubhoffer
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology; D004675:Encephalitis, Tick-Borne / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007121:Immunocompetence / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology; D016513:Mice, SCID / Q000276:immunology*; D010243:Paralysis / Q000276:immunology / Q000469:parasitology; D013045:Species Specificity; D017741:Survivors; D019562:Viral Load