title: Influence of cyclic AMP on facial nerve regeneration in rats.
abstract: Promoting facial nerve regeneration is a significant challenge.
  
  
  OBJECTIVE
  To evaluate the possible neurotrophic influence of cyclic AMP on facial nerve regeneration of Wistar rats.
  
  
  METHODS
  The right facial nerve of thirty-two animals were completely transected and immediately sutured, followed by exposure or not to topical cyclic AMP. Behavioral and histometric analyses were done at 14 and 28 days.
  
  
  RESULTS
  Statistical differences (p<0.05) were found in the behavioral and histometric analyses on the 14th day, suggesting an early regenerative response of the facial nerve to cAMP exposure.
  
  
  CONCLUSIONS
  This study demonstrates a possible neurotrophic effect of cAMP on facial nerve regeneration in rats.
authors.affiliation: Master's degree in otorhinolaryngology; doctoral student. Electronic address: andreiborin@hotmail.com.
authors.forename: Andrei
authors.initials: A
authors.lastname: Borin
authors.affiliation: Biologist and doctorate in biochemistry; researcher at the Centro de Biotecnologia, Instituto Butantan.
authors.forename: Ronaldo Nunes
authors.initials: RN
authors.lastname: Toledo
authors.affiliation: Doctorate in otorhinolaryngology, adjunct professor, otorhinolaryngology discipline, UNIFESP/EPM.
authors.forename: Paulo Lee
authors.initials: PL
authors.lastname: Ho
authors.affiliation: Livre-docente (habilitation) professor, affiliated professor, otorhinolaryngology discipline, UNIFESP/EPM.
authors.forename: José Ricardo Gurgel
authors.initials: JRG
authors.lastname: Testa
authors.affiliation: Livre-docente (habilitation) professor, otorhinolaryngology discipline, UNIFESP/EPM. Otorhinolaryngology and Head & Neck Department, Universidade Federal de Sao Paulo.
authors.forename: Oswaldo Laércio Mendonça
authors.initials: OLM
authors.lastname: Cruz
authors.affiliation: Livre-docente (habilitation) professor, otorhinolaryngology discipline, UNIFESP/EPM. Otorhinolaryngology and Head & Neck Department, Universidade Federal de Sao Paulo.
authors.forename: Yotaka
authors.initials: Y
authors.lastname: Fukuda
mesh_terms: D000287:Administration, Topical; D000704:Analysis of Variance; D000818:Animals; D000242:Cyclic AMP / Q000494:pharmacology*; D005154:Facial Nerve / Q000187:drug effects / Q000502:physiology*; D020220:Facial Nerve Injuries / Q000601:surgery*; D006801:Humans; D008297:Male; D023421:Models, Animal; D009414:Nerve Growth Factors / Q000502:physiology; D009416:Nerve Regeneration / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013536:Suture Techniques
chemical_list: D009414:Nerve Growth Factors; D000242:Cyclic AMP