title: Absence of Pneumocystis jirovecii dihydropteroate synthase gene mutations among samples from a group of AIDS patients in China.
abstract: Pneumocystis jirovecii dihydropteroate synthase (DHPS) gene mutations are associated with failure of sulfur prophylaxis of Pneumocystis pneumonia. Here the P. jirovecii DHPS gene was amplified from bronchoalveolar fluid of 10 AIDS patients in China. No DHPS gene mutations were observed. The results suggest that the prevalence of DHPS mutations in China may be low.
authors.affiliation: Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan 2nd Road, Guangzhou510080, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Li
authors.forename: Ai
authors.initials: A
authors.lastname: He
authors.forename: Wei Ping
authors.initials: WP
authors.lastname: Cai
authors.forename: Xiao Ping
authors.initials: XP
authors.lastname: Tang
authors.forename: Xiao Ying
authors.initials: XY
authors.lastname: Zheng
authors.forename: Zhuo Ya
authors.initials: ZY
authors.lastname: Li
authors.forename: Xi Mei
authors.initials: XM
authors.lastname: Zhan
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000382:microbiology*; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D002681:China; D004094:Dihydropteroate Synthase / Q000235:genetics*; D005260:Female; D005800:Genes, Fungal; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D045363:Pneumocystis carinii / Q000201:enzymology / Q000235:genetics* / Q000302:isolation & purification; D011020:Pneumonia, Pneumocystis / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D004094:Dihydropteroate Synthase