title: Appearance of lung metastasis from osteosarcoma 21 years after initial treatment.
abstract: This report describes a case of metastasis to the lung 21 years after the initial treatment of primary osteosarcoma in a 79-year-old man. The osteosarcoma was in the right femur and had resulted in amputation. The patient presented with painless hematuria, and a workup revealed a squamous cell carcinoma of the urinary bladder with invasion into the perivesicular fat. The patient received radiation therapy. Follow-up computed tomography of the chest revealed a nodule measuring 21x14 mm in the right upper lobe of the lung. Repeated transbronchial lung biopsies and needle biopsies were unsuccessful, so wedge resection of the right upper nodule was performed by video-assisted thoracic surgery to obtain a definitive diagnosis. The final pathological diagnosis was consistent with metastasis from the primary osteosarcoma removed 21 years earlier.
authors.affiliation: Division of Thoracic Surgery, Matsue Red Cross Hospital, 200 Horomachi, Matsue, Shimane, 690-8506, Japan. ryomaedamatsue@yahoo.co.jp
authors.forename: Ryo
authors.initials: R
authors.lastname: Maeda
authors.forename: Noritaka
authors.initials: N
authors.lastname: Isowa
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Onuma
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Miura
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Touge
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kawasaki
mesh_terms: D000368:Aged; D000671:Amputation, Surgical; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy; D005266:Femoral Neoplasms / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary*; D008297:Male; D012516:Osteosarcoma / Q000556:secondary*; D018714:Radiotherapy, Adjuvant; D020775:Thoracic Surgery, Video-Assisted; D014057:Tomography, X-Ray Computed; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000628:therapy; D013520:Urologic Surgical Procedures