title: [An open study evaluating the efficacy and security of magnesium and vitamin B(6) as a treatment of Tourette syndrome in children].
abstract: OBJECTIVE
  We intended to ascertain the effectiveness and safety of oral solutions of magnesium and vitamin B(6) in alleviating the symptoms emerged during clinical exacerbations in children aged 7-14 years suffering from Tourette syndrome (TS). We also aimed to determine the mean and the standard deviation of such an improvement in order to estimate sample sizes in future assays with a control group.
  
  
  METHODS
  The treatment under investigation was administered to children diagnosed with TS, in accordance with Diagnostic and Statistical Manual of Mental Disorders, fourth edition -IV, under conditions of clinical exacerbation. The effects were scored on the Yale Global Tics Severity Scale (YGTSS) at 0, 15, 30, 60 and 90 days.
  
  
  RESULTS
  The total tics score decreased from 26.7 (t0) to 12.9 (t4) and the total effect on the YGTSS was a reduction from 58.1 to 18.8. Both results were statistically significant. With respect to the application of conventional treatment or otherwise, no significant differences were observed. No side effects were seen.
  
  
  CONCLUSIONS
  The treatment assayed is safe and effective in reducing the harmful effects of TS in children. Further studies are needed, with a control group, and evaluation of different doses of the drugs.
authors.affiliation: Departamento de Anestesia y Reanimación. Hospital Costa del Sol. Marbella. Málaga. España. drgarcia.anest@telefonica.net
authors.forename: Rafael
authors.initials: R
authors.lastname: García-López
authors.forename: Julio
authors.initials: J
authors.lastname: Romero-González
authors.forename: Emilio
authors.initials: E
authors.lastname: Perea-Milla
authors.forename: César
authors.initials: C
authors.lastname: Ruiz-García
authors.forename: Francisco
authors.initials: F
authors.lastname: Rivas-Ruiz
authors.forename: Mariano
authors.initials: M
authors.lastname: de Las Mulas Béjar
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D008274:Magnesium / Q000627:therapeutic use*; D008297:Male; D010865:Pilot Projects; D005879:Tourette Syndrome / Q000188:drug therapy*; D025101:Vitamin B 6 / Q000627:therapeutic use*; D014803:Vitamin B Complex / Q000627:therapeutic use*
chemical_list: D014803:Vitamin B Complex; D025101:Vitamin B 6; D008274:Magnesium