A cost per live birth comparison of HMG and rFSH randomized trials.
To help inform healthcare treatment practices and funding decisions, an economic evaluation was conducted to compare the two leading gonadotrophins used for IVF in Belgium. Based on the results of a recently published meta-analysis, a simulated decision tree model was constructed with four states: (i) fresh cycle, (ii) cryopreserved cycle, (iii) live birth and (iv) treatment withdrawal. Gonadotrophin costs were based on highly purified human menopausal gonadotrophin (HP-HMG; Menopur) and recombinant FSH (rFSH) alpha (Gonal-F). After one fresh and one cryopreserved cycle the average treatment cost with HP-HMG was lower than with rFSH (HP-HMG euro3635; rFSH euro4103). The average cost saving per person started on HP-HMG when compared with rFSH was euro468. Additionally, the average costs per live birth of HP-HMG and rFSH were found to be significantly different: HP-HMG euro9996; rFSH euro13,009 (P < 0.0001). HP-HMG remained cost-saving even after key parameters in the model were varied in the probabilistic sensitivity analysis. Treatment with HP-HMG was found to be the dominant treatment strategy in IVF because of improved live birth rates and lower costs. Within a fixed healthcare budget, the cost-savings achieved using HP-HMG would allow for the delivery of additional IVF cycles.
Connolly
Mark
M
Market Access, Ferring International Centre, St. Prex, Switzerland. mark@gmasoln.com
De Vrieze
Kathleen
K
Ombelet
Willem
W
Schneider
Dirk
D
Currie
Craig
C
D003362:Cost-Benefit Analysis; D015925:Cryopreservation; D004470:Economics, Medical; D005260:Female; D005640:Follicle Stimulating Hormone / Q000191:economics*; D006801:Humans; D050498:Live Birth / Q000191:economics; D008596:Menotropins / Q000191:economics*; D016471:Ovarian Hyperstimulation Syndrome / Q000188:drug therapy*; D011247:Pregnancy; D011336:Probability; D011994:Recombinant Proteins / Q000191:economics; D027724:Reproductive Techniques, Assisted / Q000191:economics; D012680:Sensitivity and Specificity; D016896:Treatment Outcome
D011994:Recombinant Proteins; D008596:Menotropins; D005640:Follicle Stimulating Hormone