[Immunomodulatory effect of Indian ginseng root extract on immunodeficiency mice].
OBJECTIVE
To investigate the immunoregulation action of Indian ginseng root extract (IRRE) in immunodeficiency mice.


METHODS
Immunodeficiency mice were fed IRRE with doses of 5, 2.5, 0.85 g x kg(-1) for 15 days before their immune function were observed.


RESULTS
IRRE could relieve retarded growth and viscera index drop of mice induced by CP, could heighten the response of delayed hypersensitivity and the amount of antibody in serum. The proliferation of ConA-induced mitogenic response for spleen lymphocyte were also increased, compared with the CP group (P < 0.05). IRRE could enhance the content of marrow DNA and NO of serum with no change of acid phosphatase and alkalinity phosphatase.


CONCLUSIONS
IRRE could enhance the phagocytosis of celiac macrophage, protect the spleen from damage and improve marrow inhibition in immunodeficiency mice.
Zhou
Cai-qiong
CQ
Food Science College, Southwest University, Chongqing 400716, China. zhoucaiqiong@swu.edu.cn
Zhang
Yu
Y
D000818:Animals; D005260:Female; D007153:Immunologic Deficiency Syndromes; D008297:Male; D051379:Mice; D005894:Panax / Q000737:chemistry*; D010587:Phagocytosis / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D013154:Spleen / Q000187:drug effects*
D010936:Plant Extracts