Determination of atenolol at a graphite-polyurethane composite electrode.
A bare graphite-polyurethane composite was evaluated as an alternative electrode in the determination of atenolol (ATN) in pharmaceutical formulations. Using a DPV procedure, a linear analytical curve was observed in the 4-100mumolL(-1) range with a LOD=3.16mumolL(-1), without need of surface renewing between successive runs, with recoveries between 95.5 and 108%. Interference of other antihypertensive drugs was observed, but not from the usual components of tablets. The results of the proposed method agreed with HPLC ones within 95% confidence level.
Cervini
Priscila
P
Universidade de Sao Paulo, Instituto de Quimica de Sao Carlos, Av. do Trabalhador Sancarlense, 400, 13566-590 Sao Carlos, SP, Brazil.
Ramos
Luiz Antônio
LA
Cavalheiro
Eder Tadeu Gomes
ET