Recovery of cognitive function after traumatic brain injury: a multilevel modeling analysis of Canadian outcomes.
OBJECTIVE
To ascertain patterns of cognitive recovery during the first year after traumatic brain injury (TBI). Specifically, differential recovery across cognitive domains was investigated.


METHODS
Prospective, longitudinal, naturalistic, 1-year follow-up study.


METHODS
Large, urban inpatient neurorehabilitation program.


METHODS
Patients (N=75) with moderate to severe TBI.


METHODS
Not applicable.


METHODS
Patients with TBI were followed over the course of 1 year, during which participants' neuropsychological status was repeatedly evaluated at 3 time points (2, 5, and 12 months postinjury).


RESULTS
Multilevel modeling results were consistent with previous research, demonstrating that recovery in the first year postinjury is asymptotic in nature, with more accelerated recovery occurring during the first 5 to 6 months. Importantly, results also suggest that recovery is not uniform across cognitive domains. From 2 to 5 months postinjury, steeper recovery curves were revealed for indices of memory, speeded executive function, verbal abstraction, and manual dexterity relative to untimed tests of executive function and word knowledge. Recovery trajectories did not significantly vary as a function of cognitive domain over the course of the last 5 to 12 months.


CONCLUSIONS
These results are the first to explore trajectories of recovery directly as a function of multiple cognitive domains. They are expected to have implications for rehabilitative efforts as well as our understanding of the architecture of natural recovery after TBI.
Christensen
Bruce K
BK
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
Colella
Brenda
B
Inness
Elizabeth
E
Hebert
Deborah
D
Monette
Georges
G
Bayley
Mark
M
Green
Robin E
RE
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001930:Brain Injuries / Q000453:epidemiology / Q000534:rehabilitation*; D003071:Cognition / Q000502:physiology*; D004185:Disability Evaluation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009864:Ontario / Q000453:epidemiology; D011379:Prognosis; D011446:Prospective Studies; D020127:Recovery of Function / Q000502:physiology*; D013997:Time Factors; D055815:Young Adult