title: Fine needle aspiration of salivary gland lesions with multinucleated giant cells.
abstract: OBJECTIVE
  To report on multinucleated giant cells (MNGCs) in salivary fine needle aspiration (FNA).
  
  
  METHODS
  The cytologic reports of salivary gland region FNA during a 10-year period was searched using the keyword giant cell in the final diagnosis or microscopic description. Cases with foreign body-type giant cells secondary to previous biopsy or FNA were excluded. Histologic correlations and immunohistochemical staining for CD68, CK, EMA, S100, HMB45 and CD1a were performed on selected cases.
  
  
  RESULTS
  Twenty-six aspiration smears containing MNGCs were identified from 1040 salivary gland FNAs (2.5%). MNGCs were seen in some reactive or inflammatory conditions, benign neoplasms and malignant neoplasms. By type of MNGC, the salivary lesions were categorized in 3 groups: those with foreign body type, osteoclast type and tumor giant cells.
  
  
  CONCLUSIONS
  MNGCs can be seen in a wide spectrum of salivary gland lesions ranging from reactive to benign and malignant. They are of nonepithelial origin or can be of true neoplastic nature in metastatic lesions.
authors.affiliation: Department of Cytopathology and Hematopathology, Dr. Daneshbod Pathology Laboratory, and Departanent of Otolaryngology, Head and Neck Surgery, Shiraz School of Medicine, Shiraz, Iran. y@daneshbod.com
authors.forename: Yahya
authors.initials: Y
authors.lastname: Daneshbod
authors.forename: Bijan
authors.initials: B
authors.lastname: Khademi
authors.forename: Maryam
authors.initials: M
authors.lastname: Kadivar
authors.forename: Parvin
authors.initials: P
authors.lastname: Ganjei-Azar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D044963:Biopsy, Fine-Needle; D005260:Female; D005870:Giant Cell Tumors / Q000378:metabolism / Q000473:pathology*; D015726:Giant Cells / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D012468:Salivary Gland Neoplasms / Q000378:metabolism / Q000473:pathology*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor