title: The effect of domestication on the fungal proteome.
abstract: The molecular effect of domestication has rarely been examined in fungi. I examined the molecular signature of domestication on Aspergillus oryzae, a fungus used to ferment several Japanese food products. The ratio of nonsynonymous to synonymous substitutions and the percentage of estimated deleterious substitutions along the A. oryzae lineage were lower than those in the wild sister lineage Aspergillus flavus. The patterns of genetic change observed in human-mediated domestication of animals and plants might not be typical in domesticated fungi.
authors.affiliation: Vanderbilt University, Department of Biological Sciences, VU Station B 351634, Nashville, TN 37235, USA. antonis.rokas@vanderbilt.edu
authors.forename: Antonis
authors.initials: A
authors.lastname: Rokas
mesh_terms: D001231:Aspergillus flavus / Q000235:genetics*; D001236:Aspergillus oryzae / Q000235:genetics*; D019143:Evolution, Molecular; D014644:Genetic Variation; D016681:Genome, Fungal; D020543:Proteome / Q000235:genetics* / Q000378:metabolism
chemical_list: D020543:Proteome