title: Selective excretion of anti-inflammatory cytokine interleukin-10 in a superantigen-inducing neonatal infectious disease.
abstract: Neonatal toxic shock syndrome (TSS)-like exanthematous disease (NTED) is an emerging neonatal infectious disease caused by TSS toxin-1 (TSST-1). Although NTED and TSS are caused by the same superantigenic exotoxin, NTED is less severe than TSS. The mechanism of this reduced severity in NTED has not been elucidated. Thirteen patients with NTED were enrolled in the study. We investigated serum cytokine profile using a cytometric bead array system with a cytokine panel. Expression of Vbeta2 and CD45RO in CD4(+) T cells was investigated in mononuclear cells by using flowcytometry. Ten patients with other bacterial infections and eight patients without any infections were also enrolled as control groups. The mean serum level of IL-10 was 1209.9 pg/mL in patients with NTED at the time of admission into the study. The other inhibitory cytokine, IL-4, exhibited a minimum level. The high level of IL-10 rapidly decreased within 3-9 days of the onset of NTED. The cytokine profile of NTED, with its high IL-10 level, was clearly different from that of the other bacterial infections. The increased level of IL-10 seems to be related to the reduced severity of NTED. Th2 shift is not thought to be the cause of this IL-10 excretion.
authors.affiliation: Department of Pediatrics, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi-ken 329-0498, Japan. naoto-t@jichi.ac.jp
authors.forename: Naoto
authors.initials: N
authors.lastname: Takahashi
authors.forename: Hisaya
authors.initials: H
authors.lastname: Hasegawa
authors.forename: Mami
authors.initials: M
authors.lastname: Komiyama
authors.forename: Takehiro
authors.initials: T
authors.lastname: Ohki
authors.forename: Yukari
authors.initials: Y
authors.lastname: Yada
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Koike
authors.forename: Ryou
authors.initials: R
authors.lastname: Kawamata
authors.forename: Yoko
authors.initials: Y
authors.lastname: Honma
authors.forename: Mariko
authors.initials: M
authors.lastname: Momoi
mesh_terms: D001427:Bacterial Toxins / Q000276:immunology*; D001724:Birth Weight; D016207:Cytokines / Q000097:blood / Q000276:immunology; D004768:Enterotoxins / Q000276:immunology*; D005076:Exanthema / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000276:immunology* / Q000382:microbiology* / Q000503:physiopathology; D016753:Interleukin-10 / Q000378:metabolism*; D011247:Pregnancy; D040081:Protein Array Analysis; D012772:Shock, Septic / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology; D018089:Superantigens / Q000276:immunology*
chemical_list: D001427:Bacterial Toxins; D016207:Cytokines; D004768:Enterotoxins; D018089:Superantigens; C030107:enterotoxin F, Staphylococcal; D016753:Interleukin-10