PirB, a second receptor for the myelin inhibitors of axonal regeneration Nogo66, MAG, and OMgp: implications for regeneration in vivo.
Inhibitors of axonal regeneration in myelin are believed to be major contributors to the lack of regeneration in the adult CNS. Three of the four known myelin inhibitors, although very different structurally, interact with the same receptor, NgR. However, the absence of NgR has no effect on inhibition of neurite outgrowth in culture, and there is no improvement in CST regeneration in vivo. In a recent issue of Science, a second receptor for these myelin inhibitors was described, PirB, a receptor first described in the immune system. Will PirB be the answer to CST regeneration in vivo?
Filbin
Marie T
MT
Biology Department, Hunter College, 695 Park Avenue, New York, NY 10065, USA. filbin@genectr.hunter.cuny.edu
D000818:Animals; D051379:Mice; D009185:Myelin Proteins / Q000378:metabolism*; D009186:Myelin Sheath / Q000378:metabolism*; D009416:Nerve Regeneration / Q000235:genetics / Q000502:physiology*; D011971:Receptors, Immunologic / Q000502:physiology*
D009185:Myelin Proteins; D011971:Receptors, Immunologic