Association of retinol-binding protein-4 with dietary selenium intake and other lifestyle features in young healthy women.
OBJECTIVE
This study specifically assessed plasma retinol-binding protein-4 (RBP4), an inflammatory marker, in young healthy women, with emphasis on its potential relations to dietary intake and lifestyle features.


METHODS
Seventy-four women with a mean age of 20.5 +/- 2.5 y and body mass index of 21.3 +/- 2.3 kg/m(2) were enrolled. Anthropometric, blood pressure, glucose, lipid profile, RBP4, and insulin concentrations were determined. Nutritional intakes were estimated by a validated semiquantitative food-frequency questionnaire. Physical activity and smoking status were evaluated with appropriate tools.


RESULTS
Regarding anthropometric and biochemical variables, only triacylglycerol concentration had a positive and significant association with plasma RBP4 concentrations (P < 0.001). Trans fatty acid intake, vitamin A intake, and smoking time showed positive and significant correlations with RBP4 concentrations (P < 0.05). Furthermore, individuals with a higher selenium intake (P = 0.027), non-smoking participants (P = 0.032), and subjects who self-declared to practice some physical activity (P = 0.030) presented significantly lower RBP4 concentrations. Interestingly, selenium intake was inversely and significantly associated with RBP4 concentration (P = 0.018) when adjusted for smoking status, energy intake, and vitamin C, vitamin E, and zinc intakes. Plasma RBP4 concentrations were also associated with smoking status (P = 0.035), adjusted for potential confounding factors.


CONCLUSIONS
This translational research revealed that dietary intake of a nutrient with an impact on oxidative stress such as selenium and lifestyle features such as smoking habit can modulate RBP4 concentrations. Our results suggest that plasma RBP4 values could be a valuable tool to screen potential nutrient and inflammation interactions.
Hermsdorff
Helen Hermana Miranda
HH
Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Pamplona, Spain.
Zulet
M Angeles
MA
Puchau
Blanca
B
Bressan
Josefina
J
Martínez
J Alfredo
JA
D000293:Adolescent; D000975:Antioxidants / Q000008:administration & dosage*; D004032:Diet; D015444:Exercise; D005227:Fatty Acids / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008019:Life Style; D054839:Retinol-Binding Proteins, Plasma / Q000032:analysis*; D012643:Selenium / Q000008:administration & dosage*; D012907:Smoking / Q000097:blood; D014131:Trace Elements / Q000008:administration & dosage; D014280:Triglycerides / Q000097:blood*; D014801:Vitamin A / Q000008:administration & dosage; D014815:Vitamins / Q000008:administration & dosage; D055815:Young Adult; D015032:Zinc / Q000008:administration & dosage
D000975:Antioxidants; D005227:Fatty Acids; C101326:RBP4 protein, human; D054839:Retinol-Binding Proteins, Plasma; D014131:Trace Elements; D014280:Triglycerides; D014815:Vitamins; D014801:Vitamin A; D012643:Selenium; D015032:Zinc