[Anti-fungi activity of organic extracts from the tree Fagara monophylla (Rutaceae) in Venezuela].
The tree Fagara monophylla ranges throughout Tropical America. The genus Fagara has a diversity of alkaloid compounds with antibiotic properties; nevertheless, there are few reports antifungal activity of its organic compounds. Organic extracts from Venezuelan F. monophylla were tested for antimicrobial activity against Aspergillus terreus, A. flavus, Penicillium digitatum, P. funiculosum, P. citrinum, Paecilomyces and Candida albicans. Minimal Inhibitory Concentration (MIC) was determined. The susceptibility trials of organic fractions (Hex., CH2Cl2 and MeOH) showed that the highest inhibition was presented by MeOH against A. flavus (55 mm), P. digitatum (60 mm), P. funiculosum (56 mm) and C. albicans (26 mm). The activities of MeOH/EtOAc fractions 1 and 2 suggest a combined effect against A. flavus, P. digitatum and P. funiculosum. The MIC of 1 MeOH/ EtOAc subfraction activity was lower against C. albicans (32 microg/ml) and moderate (128 microg/ml) against P. digitatum. This organic extract has a great antifungal potential. The phytochemical proves and TLC testing on the organic extract, and the MeOH/EtOAc subfraction, respectively, indicated the presence of alkaloid compounds.
Gómez
Yrma
Y
Dpto. de Ciencias, Laboratorio de Investigaciones Biológicas, Universidad de Oriente, Núcleo de Anzoátegui, Venezuela. irmagomez52@hotmail.com
Gil
Katiuska
K
González
Elba
E
Farías
Luz Marina
LM
D000935:Antifungal Agents / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D027821:Rutaceae / Q000737:chemistry*; D014687:Venezuela
D000935:Antifungal Agents; D010936:Plant Extracts