Reversible inactivation and excitation of nucleus raphe magnus can modulate tail blood flow of male Wistar rats in response to hypothermia.
The nucleus raphe magnus (NRM) is involved in thermoregulatory processing. There is a correlation between changes in the firing rates of the cells in the NRM and the application of the peripheral thermal stimulus.



we examined the effect of reversible inactivation and excitation of NRM on mechanisms involved in tail blood flow (TBF) regulation in hypothermia.



Hypothermia was induced in Male Wistar rats and cannula was implanted above the NRM. To evaluate the effect of nucleus inactivation on TBF, the amount of TBF was measured by Laser Doppler in hypothermic rats, before and after lidocaine microinjection into NRM. TBF was also measured after glutamate microinjection to assess the effect of nucleus excitation in hypothermic rats.



Results indicated that after dropping TBF by hypothermia, microinjection of lidocaine into NRM significantly decreased TBF from 54.43 +- 5.7 to 46.81 +- 3.4, whereas glutamate microinjection caused a significant increase from 44.194 +- 0.6 to 98 +- 10.0 CONCLUSION: These data suggest that NRM have thermoregulatory effect in response to hypothermia.
Malakouti
Seyed Mansour
SM
Dept. of Physiology, Hamadan University of Medical Sciences, Hamadan, Iran.
Kourosh Arami
Masoomeh
M
Dept. of Physiology, Tarbiat Modares University, Tehran, Iran.
Sarihi
Abdorahman
A
Dept. of Physiology, Hamadan University of Medical Sciences, Hamadan, Iran.
Hajizadeh
Sohrab
S
Dept. of Physiology, Tarbiat Modares University, Tehran, Iran.
Behzadi
Gila
G
Dept. of Physiology, Beheshti University, Tehran, Iran.
Shahidi
Siamak
S
Dept. of Physiology, Beheshti University, Tehran, Iran.
Komaki
Alireza
A
Dept. of Physiology, Hamadan University of Medical Sciences, Hamadan, Iran.
Heshmatian
Behnam
B
Dept. of Physiology, School of Medicine, Uromia University of Medical Sciences, Uromia, Iran.
Vahabian
Mehrangiz
M
Dept. of Language, Hamadan University of Medical Sciences, Hamadan, Iran.
D000818:Animals; D007035:Hypothermia / Q000503:physiopathology*; D008297:Male; D011903:Raphe Nuclei / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013623:Tail / Q000098:blood supply* / Q000503:physiopathology*; D013821:Thermometers