title: Effects of vitamin D receptor gene polymorphisms on low-resistance training using exercise machines: the 'Power Rehabilitation' program.
abstract: The enhancement and promotion of health is necessary to maintain the quality of life (QOL) of the aged population in developed nations such as Japan where the number of elderly has been increasing rapidly. For this purpose, low-resistance training using exercise machines ('Power Rehabilitation') has been established as a rehabilitation program. To investigate the individual factors which influence the effects of 'Power Rehabilitation', single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene and the ciliary neurotrophic factor (CNTF) gene were analyzed, and the relationship between SNP patterns and the effects of 'Power Rehabilitation' was evaluated. 'Power Rehabilitation' had an effect on the physiological functions involved in the activities of daily life (ADL) rather than muscle strength and size. In addition, certain SNP patterns showed better improvement of parameters associated with the effects of 'Power Rehabilitation' as analyzed by comparison between SNP patterns and factor analysis. Large scale analyses are required to ensure this tendency and to discover individual factors which may help to promote the health and QOL of the aged population.
authors.affiliation: Fukushima Rehabilitation Academy, 18089-31 Yorishima, Asakuchi 714-0101, Japan.
authors.forename: Shin-Ichiro
authors.initials: S
authors.lastname: Murakami
authors.forename: Takemi
authors.initials: T
authors.lastname: Otsuki
authors.forename: Megumi
authors.initials: M
authors.lastname: Maeda
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Miura
authors.forename: Seiko
authors.initials: S
authors.lastname: Morii
authors.forename: Kenji
authors.initials: K
authors.lastname: Kiyokane
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Hayakawa
authors.forename: Atsushi
authors.initials: A
authors.lastname: Maeda
authors.forename: Takayo
authors.initials: T
authors.lastname: Imakawa
authors.forename: Shunpei
authors.initials: S
authors.lastname: Harada
authors.forename: Torataro
authors.initials: T
authors.lastname: Handa
authors.forename: Yasumitsu
authors.initials: Y
authors.lastname: Nishimura
authors.forename: Shuko
authors.initials: S
authors.lastname: Murakami
authors.forename: Naoko
authors.initials: N
authors.lastname: Kumagai
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Hayashi
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.forename: Shin-Ichiro
authors.initials: S
authors.lastname: Suemori
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Fukushima
authors.forename: Seikoh
authors.initials: S
authors.lastname: Nishida
authors.forename: Keisuke
authors.initials: K
authors.lastname: Fukushima
mesh_terms: D000203:Activities of Daily Living; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D020934:Ciliary Neurotrophic Factor / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011788:Quality of Life; D018167:Receptors, Calcitriol / Q000235:genetics*; D012046:Rehabilitation; D055070:Resistance Training
chemical_list: D020934:Ciliary Neurotrophic Factor; D018167:Receptors, Calcitriol