title: [Relation between fresh plasma administration and morbidity in patients with HELLP syndrome].
abstract: BACKGROUND
  HELLP syndrome is a complication of severe preeclampsia; its incidence goes from 0.1 to 0.6% of pregnancies, and causes complications in 4% of patients.
  
  
  OBJECTIVE
  To evaluate frozen fresh plasma administration to prevent pregnancy complications in patients with HELLP syndrome.
  
  
  METHODS
  Retrospective, comparative and non-randomized study. Patients with HELLP syndrome were divided in two groups: first one (n=23) was treated with fresh frozen plasma (10 mL/kg/day), and second one (n=29) with dexamethasone. Complications, dialysis requirement, hospital stay, and mortality were compared (chi2 test was used).
  
  
  RESULTS
  Group 1 (n=23) had nine patients with HELLP syndrome type I, and 14 with type II. Group 2 (n=29) had 20 cases with HELLP syndrome type I, and nine with type II. Most frequent complication in group 1 was acute renal failure (22%), and hospital stay was 4.5 days. Group 2 had 13 patients with acute renal failure, three with pulmonary edema, one with cerebral edema, one with hepatic fracture, and one with placenta detachment. Hospital stay was from 8 to 30 days (p < 0.002). There were no maternal deaths in both groups.
  
  
  CONCLUSIONS
  Fresh frozen plasma meaningfully reduces (43%) complications, hospital stay, and hemodialysis requirement (45%) in patients with HELLP syndrome.
authors.affiliation: Unidad de Cuidados Intensivos de Adultos, IMSS, Monterrey, NL, Mexico.
authors.forename: Juana María
authors.initials: JM
authors.lastname: Montoya Ramírez
authors.forename: Ricardo Max
authors.initials: RM
authors.lastname: Pacheco Cartagena
authors.forename: Raúl
authors.initials: R
authors.lastname: Cortés Flores
authors.forename: Ricardo J
authors.initials: RJ
authors.lastname: Hernández Herrera
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D017359:HELLP Syndrome / Q000628:therapy*; D006801:Humans; D010949:Plasma; D011247:Pregnancy; D011248:Pregnancy Complications / Q000517:prevention & control; D012189:Retrospective Studies; D055815:Young Adult