title: Heterodimers and receptor mosaics of different types of G-protein-coupled receptors.
abstract: Through an assembly of interacting GPCRs, heterodimers and high-order heteromers (termed receptor mosaics) are formed and lead to changes in the agonist recognition, signaling, and trafficking of participating receptors via allosteric mechanisms, sometimes involving the appearance of cooperativity. This field has now become a major research area, and this review deals with their physiology being integrators of receptor signaling in the CNS and their use as targets for novel drug development based on their unique pharmacology.
authors.affiliation: Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden. Kjell.Fuxe@ki.se
authors.forename: Kjell
authors.initials: K
authors.lastname: Fuxe
authors.forename: Daniel
authors.initials: D
authors.lastname: Marcellino
authors.forename: Diego
authors.initials: D
authors.lastname: Guidolin
authors.forename: Amina S
authors.initials: AS
authors.lastname: Woods
authors.forename: Luigi F
authors.initials: LF
authors.lastname: Agnati
mesh_terms: D000818:Animals; D019281:Dimerization; D000939:Epitopes; D006801:Humans; D008958:Models, Molecular; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry* / Q000235:genetics* / Q000502:physiology; D009626:Terminology as Topic
chemical_list: D000939:Epitopes; D043562:Receptors, G-Protein-Coupled