Inherited thrombophilia and preeclampsia within a multicenter cohort: the Montreal Preeclampsia Study.
OBJECTIVE
We sought to evaluate the association between inherited thrombophilia and preeclampsia.


METHODS
From a multicenter cohort of 5337 pregnant women, we prospectively identified 113 women who developed preeclampsia and selected 443 control subjects who did not have preeclampsia or nonproteinuric gestational hypertension. Blood samples were tested for DNA polymorphisms affecting thrombophilia (factor V Leiden mutation, prothrombin G20210A mutation, methylenetetrahydrofolate reductase C677T polymorphism), homocysteine, and folate levels, and placentae underwent pathological evaluation.


RESULTS
Thrombophilia was present in 14% of patients and 21% of control subjects (adjusted logistic regression odds ratio, 0.6; 95% confidence interval, 0.3-1.3). Placental underperfusion was present in 63% of patients vs 46% of control subjects (P < .001) and was more frequent in women with folate levels in the lowest quartile (P = .04), but was not associated with thrombophilia.


CONCLUSIONS
We did not find evidence to support an association between inherited thrombophilia and increased risk of preeclampsia. Placental underperfusion is associated with preeclampsia, but this does not appear to be consequent to thrombophilia.
Kahn
Susan R
SR
Department of Medicine, McGill University Faculty of Medicine, Montreal, QC, Canada. susan.kahn@mcgill.ca
Platt
Robert
R
McNamara
Helen
H
Rozen
Rima
R
Chen
Moy Fong
MF
Genest
Jacques
J
Goulet
Lise
L
Lydon
John
J
Seguin
Louise
L
Dassa
Clement
C
Masse
André
A
Asselin
Guylaine
G
Benjamin
Alice
A
Miner
Louise
L
Ghanem
Antoinette
A
Kramer
Michael S
MS
D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D010920:Placenta / Q000098:blood supply; D010922:Placenta Diseases / Q000209:etiology; D011225:Pre-Eclampsia / Q000209:etiology*; D011247:Pregnancy; D011446:Prospective Studies; D011792:Quebec; D019851:Thrombophilia / Q000150:complications* / Q000235:genetics; D055815:Young Adult