Versatile Pd(II)-catalyzed C-H activation/aryl-aryl coupling of benzoic and phenyl acetic acids.
The use of aryltrifluoroborates as coupling partners and O(2) as the oxidant substantially improves the scope and practicality of the Pd-catalyzed C-H activation/C-C coupling reaction. The newly discovered protocol made possible, for the first time, the ortho-coupling of electron-deficient arenes and phenyl acetic acids with organometallic reagents.
Wang
Dong-Hui
DH
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Mei
Tian-Sheng
TS
Yu
Jin-Quan
JQ
D001565:Benzoates / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000138:chemical synthesis*; D001881:Borates / Q000737:chemistry; D002384:Catalysis; D009942:Organometallic Compounds / Q000737:chemistry; D010165:Palladium / Q000737:chemistry; D010648:Phenylacetates / Q000737:chemistry*
D001565:Benzoates; D001713:Biphenyl Compounds; D001881:Borates; D009942:Organometallic Compounds; D010648:Phenylacetates; D010165:Palladium; C025136:phenylacetic acid