Cytologic accuracy of samples obtained by endobronchial ultrasound-guided transbronchial needle aspiration at Thomas Jefferson University Hospital.
OBJECTIVE
To evaluate the diagnostic yield and cytologic accuracy of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in cases of clinically suspected epithelial malignancy, sarcoidosis and lymphoma.


METHODS
Over a 9-month period from inception at Thomas Jefferson University Hospital, a retrospective analysis of the cytologic diagnoses of all EBUS-TBNA procedures performed in 48 patients was undertaken. The patients were divided into 2 groups, those with clinical suspicion of an epithelial malignancy and those with clinical suspicion of sarcoidosis or lymphoma.


RESULTS
Of the 48 patients who underwent EBUS-TBNA, 39 had adequate fine needle aspiration biopsy samples (60 of 78) with a diagnostic yield of 77%; the pre-EBUS yield was 58%. For the group with malignant disease the calculated sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were all 100%. For the group with benign disease the calculated sensitivity, specificity, PPV and NPV were also 100%.


CONCLUSIONS
Preliminary results show that cytologic samples obtained via BUS-TBNA are accurate and specific in making a diagnosis of an epithelial malignancy or benign disease.
Jacob-Ampuero
Marie-Paule
MP
Department of Pathology, Thomas Jefferson University, USA. luniemj@yahoo.com
Haas
Andrew R
AR
Ciocca
Vincenzo
V
Bibbo
Marluce
M
D044963:Biopsy, Fine-Needle / Q000379:methods*; D001980:Bronchi / Q000473:pathology*; D001999:Bronchoscopy; D003581:Cytodiagnosis; D019160:Endosonography; D005189:False Positive Reactions; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012507:Sarcoidosis / Q000175:diagnosis* / Q000000981:diagnostic imaging; D012680:Sensitivity and Specificity