title: [Effect of verapamil on pharmacokinetics of puerarin in rats].
abstract: OBJECTIVE
  To investigate the effect of verapamil on the pharmacokinetics of puerarin in rats.
  
  
  METHODS
  Puerarin with or without verapamil was administered intravenously or orally to rats. The concentration of puerarin in serum was determined by HPLC.
  
  
  RESULTS
  No significant difference was found between the control and 0.5 microg x g(-1) verapamil combined groups for intravenous administration, and there was significant difference between the control and 2. 5 microg x g(-1) verapamil combined groups (P < 0.05). When puerarin was administered orally with verapamil, significant difference was found between the control and combined groups (P < 0.05).
  
  
  CONCLUSIONS
  Verapamil inhibited puerarin metabolism when puerarin was coadministered with verapamil, so it is necessary to change the therapeutic dose of puerarin.
authors.affiliation: Department of Traditional Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou 510006, China. cuishengmiao@yahoo.com
authors.forename: Sheng-miao
authors.initials: SM
authors.lastname: Cui
authors.forename: Yan-bin
authors.initials: YB
authors.lastname: Ma
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004347:Drug Interactions; D007529:Isoflavones / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D014665:Vasodilator Agents / Q000493:pharmacokinetics* / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology*
chemical_list: D007529:Isoflavones; D014665:Vasodilator Agents; D014700:Verapamil; C033607:puerarin