Preoperative autologous blood donation reduces the need for allogeneic blood products: a prospective randomized study.
OBJECTIVE
We sought to assess the efficacy of preoperative autologous blood donation in reducing patient exposure to allogeneic blood products following elective cardiac surgery.


METHODS
We included 48 patients in a prospective study and randomly assigned them into the control or treatment group. We excluded patients with aortic stenosis, main trunk stenosis and unstable angina. Group A (n=23; coronary disease n=21 and valvular disease n=2) was the control group, and group B (n=25; coronary disease n=21, valvular disease n=4) received preoperative autologous blood donation. All patients had cardiopulmonary bypass surgery, and we processed mediastinal blood with a cell-saver device before reinfusion. All patients received aprotinin, and we reinfused blood shed from the mediastinum postoperatively.


RESULTS
No major peri- or postoperative complications occurred. We interrupted preoperative blood donation in 2 patients (8%) because of worsened angina pectoris. The mean time between the first blood donation and surgery was 22.5 (standard deviation [SD] 9.4, range 12-50) days. In group A, 9 patients (39.1%) were exposed to allogeneic blood products. In group B, 11 patients (47.8%) were exposed to blood products (p=0.73), and 4 (16%) were exposed to allogeneic blood products (p=0.036).


CONCLUSIONS
Preoperative blood donation was completed in 92% of the targeted low-risk population. The procedure significantly reduced exposure to perioperative allogeneic blood products.
Bouchard
Denis
D
Department of Cardiovascular Surgery, Montreal Heart Institute, Montréal, Quebec. denis.bouchard@icm-mhi.org
Marcheix
Bertrand
B
Al-Shamary
Sfoug
S
Vanden Eynden
Frédéric
F
Demers
Philippe
P
Robitaille
Danielle
D
Pellerin
Michel
M
Perrault
Louis P
LP
Carrier
Michel
M
D000368:Aged; D001782:Blood Donors; D001803:Blood Transfusion; D001804:Blood Transfusion, Autologous; D006348:Cardiac Surgical Procedures; D005260:Female; D006331:Heart Diseases / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D011446:Prospective Studies; D014184:Transplantation, Homologous