Glycosylated asterisks are among the most potent low valency inducers of Concanavalin A aggregation.
A new class of sulfurated, semi-rigid, radial and low-valent glycosylated asterisk ligands with potential dual function as ligand and probe has some of the highest inhibition potencies of Con A-induced hemagglutination, by using a cross-linking mechanism of Con A which amplifies the enhancement to near nanomolar concentrations with the alpha-d-mannose asterisk.
Sleiman
Mazen
M
Laboratoire de Chimie Organique II-Glycochimie, UMR CNRS 5246, Université Claude Bernard - Lyon 1,Villeurbanne Cedex, France.
Varrot
Annabelle
A
Raimundo
Jean-Manuel
JM
Gingras
Marc
M
Goekjian
Peter G
PG
D000818:Animals; D003208:Concanavalin A / Q000737:chemistry*; D006031:Glycosylation; D006386:Hemagglutination Tests; D011817:Rabbits
D003208:Concanavalin A