title: Reconsolidation and the fate of consolidated memories.
abstract: The predominant view about memory formation states that a consolidation process stabilizes newly acquired traces until they are safely stored in the brain. However, during the last ten years evidence has accumulated to indicate that, upon retrieval, consolidated memories are rendered again vulnerable to the action of metabolic blockers, notably protein synthesis inhibitors. This has led to the hypothesis that memories are reconsolidated at the time of retrieval, and that this requires protein synthesis in different brain regions. Here we will address the consolidation-reconsolidation debate and discuss some controversial issues about the reconsolidation hypothesis, in particular the biological role of this process.
authors.affiliation: Centro de Memória, Instituto de Pesquisas Biomédicas, Pontifícia Universidade Católica do Rio Grande do Sul, Av. Ipiranga 6600, Porto Alegre, RS 90610-000, Brasil. liabevilaqua@terra.com.br
authors.forename: Lia R
authors.initials: LR
authors.lastname: Bevilaqua
authors.forename: Jorge H
authors.initials: JH
authors.lastname: Medina
authors.forename: Iván
authors.initials: I
authors.lastname: Izquierdo
authors.forename: Martín
authors.initials: M
authors.lastname: Cammarota
mesh_terms: D000818:Animals; D001245:Association Learning / Q000187:drug effects; D001921:Brain / Q000187:drug effects; D005108:Extinction, Psychological / Q000502:physiology; D008568:Memory / Q000187:drug effects* / Q000502:physiology*; D011939:Mental Recall / Q000187:drug effects; D008954:Models, Biological; D011500:Protein Synthesis Inhibitors / Q000009:adverse effects*; D051381:Rats
chemical_list: D011500:Protein Synthesis Inhibitors