title: Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
abstract: Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000). We strongly confirm FTO and MC4R and identify six additional loci (P < 5 x 10(-8)): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant). Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.
authors.affiliation: Genetic Investigation of ANthropometric Traits Consortium.
authors.forename: Cristen J
authors.initials: CJ
authors.lastname: Willer
authors.forename: Elizabeth K
authors.initials: EK
authors.lastname: Speliotes
authors.forename: Ruth J F
authors.initials: RJ
authors.lastname: Loos
authors.forename: Shengxu
authors.initials: S
authors.lastname: Li
authors.forename: Cecilia M
authors.initials: CM
authors.lastname: Lindgren
authors.forename: Iris M
authors.initials: IM
authors.lastname: Heid
authors.forename: Sonja I
authors.initials: SI
authors.lastname: Berndt
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Elliott
authors.forename: Anne U
authors.initials: AU
authors.lastname: Jackson
authors.forename: Claudia
authors.initials: C
authors.lastname: Lamina
authors.forename: Guillaume
authors.initials: G
authors.lastname: Lettre
authors.forename: Noha
authors.initials: N
authors.lastname: Lim
authors.forename: Helen N
authors.initials: HN
authors.lastname: Lyon
authors.forename: Steven A
authors.initials: SA
authors.lastname: McCarroll
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Papadakis
authors.forename: Lu
authors.initials: L
authors.lastname: Qi
authors.forename: Joshua C
authors.initials: JC
authors.lastname: Randall
authors.forename: Rosa Maria
authors.initials: RM
authors.lastname: Roccasecca
authors.forename: Serena
authors.initials: S
authors.lastname: Sanna
authors.forename: Paul
authors.initials: P
authors.lastname: Scheet
authors.forename: Michael N
authors.initials: MN
authors.lastname: Weedon
authors.forename: Eleanor
authors.initials: E
authors.lastname: Wheeler
authors.forename: Jing Hua
authors.initials: JH
authors.lastname: Zhao
authors.forename: Leonie C
authors.initials: LC
authors.lastname: Jacobs
authors.forename: Inga
authors.initials: I
authors.lastname: Prokopenko
authors.forename: Nicole
authors.initials: N
authors.lastname: Soranzo
authors.forename: Toshiko
authors.initials: T
authors.lastname: Tanaka
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Timpson
authors.forename: Peter
authors.initials: P
authors.lastname: Almgren
authors.forename: Amanda
authors.initials: A
authors.lastname: Bennett
authors.forename: Richard N
authors.initials: RN
authors.lastname: Bergman
authors.forename: Sheila A
authors.initials: SA
authors.lastname: Bingham
authors.forename: Lori L
authors.initials: LL
authors.lastname: Bonnycastle
authors.forename: Morris
authors.initials: M
authors.lastname: Brown
authors.forename: Noël P
authors.initials: NP
authors.lastname: Burtt
authors.forename: Peter
authors.initials: P
authors.lastname: Chines
authors.forename: Lachlan
authors.initials: L
authors.lastname: Coin
authors.forename: Francis S
authors.initials: FS
authors.lastname: Collins
authors.forename: John M
authors.initials: JM
authors.lastname: Connell
authors.forename: Cyrus
authors.initials: C
authors.lastname: Cooper
authors.forename: George Davey
authors.initials: GD
authors.lastname: Smith
authors.forename: Elaine M
authors.initials: EM
authors.lastname: Dennison
authors.forename: Parimal
authors.initials: P
authors.lastname: Deodhar
authors.forename: Paul
authors.initials: P
authors.lastname: Elliott
authors.forename: Michael R
authors.initials: MR
authors.lastname: Erdos
authors.forename: Karol
authors.initials: K
authors.lastname: Estrada
authors.forename: David M
authors.initials: DM
authors.lastname: Evans
authors.forename: Lauren
authors.initials: L
authors.lastname: Gianniny
authors.forename: Christian
authors.initials: C
authors.lastname: Gieger
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Gillson
authors.forename: Candace
authors.initials: C
authors.lastname: Guiducci
authors.forename: Rachel
authors.initials: R
authors.lastname: Hackett
authors.forename: David
authors.initials: D
authors.lastname: Hadley
authors.forename: Alistair S
authors.initials: AS
authors.lastname: Hall
authors.forename: Aki S
authors.initials: AS
authors.lastname: Havulinna
authors.forename: Johannes
authors.initials: J
authors.lastname: Hebebrand
authors.forename: Albert
authors.initials: A
authors.lastname: Hofman
authors.forename: Bo
authors.initials: B
authors.lastname: Isomaa
authors.forename: Kevin B
authors.initials: KB
authors.lastname: Jacobs
authors.forename: Toby
authors.initials: T
authors.lastname: Johnson
authors.forename: Pekka
authors.initials: P
authors.lastname: Jousilahti
authors.forename: Zorica
authors.initials: Z
authors.lastname: Jovanovic
authors.forename: Kay-Tee
authors.initials: KT
authors.lastname: Khaw
authors.forename: Peter
authors.initials: P
authors.lastname: Kraft
authors.forename: Mikko
authors.initials: M
authors.lastname: Kuokkanen
authors.forename: Johanna
authors.initials: J
authors.lastname: Kuusisto
authors.forename: Jaana
authors.initials: J
authors.lastname: Laitinen
authors.forename: Edward G
authors.initials: EG
authors.lastname: Lakatta
authors.forename: Jian'an
authors.initials: J
authors.lastname: Luan
authors.forename: Robert N
authors.initials: RN
authors.lastname: Luben
authors.forename: Massimo
authors.initials: M
authors.lastname: Mangino
authors.forename: Wendy L
authors.initials: WL
authors.lastname: McArdle
authors.forename: Thomas
authors.initials: T
authors.lastname: Meitinger
authors.forename: Antonella
authors.initials: A
authors.lastname: Mulas
authors.forename: Patricia B
authors.initials: PB
authors.lastname: Munroe
authors.forename: Narisu
authors.initials: N
authors.lastname: Narisu
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Ness
authors.forename: Kate
authors.initials: K
authors.lastname: Northstone
authors.forename: Stephen
authors.initials: S
authors.lastname: O'Rahilly
authors.forename: Carolin
authors.initials: C
authors.lastname: Purmann
authors.forename: Matthew G
authors.initials: MG
authors.lastname: Rees
authors.forename: Martin
authors.initials: M
authors.lastname: Ridderstråle
authors.forename: Susan M
authors.initials: SM
authors.lastname: Ring
authors.forename: Fernando
authors.initials: F
authors.lastname: Rivadeneira
authors.forename: Aimo
authors.initials: A
authors.lastname: Ruokonen
authors.forename: Manjinder S
authors.initials: MS
authors.lastname: Sandhu
authors.forename: Jouko
authors.initials: J
authors.lastname: Saramies
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Scott
authors.forename: Angelo
authors.initials: A
authors.lastname: Scuteri
authors.forename: Kaisa
authors.initials: K
authors.lastname: Silander
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Sims
authors.forename: Kijoung
authors.initials: K
authors.lastname: Song
authors.forename: Jonathan
authors.initials: J
authors.lastname: Stephens
authors.forename: Suzanne
authors.initials: S
authors.lastname: Stevens
authors.forename: Heather M
authors.initials: HM
authors.lastname: Stringham
authors.forename: Y C Loraine
authors.initials: YC
authors.lastname: Tung
authors.forename: Timo T
authors.initials: TT
authors.lastname: Valle
authors.forename: Cornelia M
authors.initials: CM
authors.lastname: Van Duijn
authors.forename: Karani S
authors.initials: KS
authors.lastname: Vimaleswaran
authors.forename: Peter
authors.initials: P
authors.lastname: Vollenweider
authors.forename: Gerard
authors.initials: G
authors.lastname: Waeber
authors.forename: Chris
authors.initials: C
authors.lastname: Wallace
authors.forename: Richard M
authors.initials: RM
authors.lastname: Watanabe
authors.forename: Dawn M
authors.initials: DM
authors.lastname: Waterworth
authors.forename: Nicholas
authors.initials: N
authors.lastname: Watkins
authors.forename: Jacqueline C M
authors.initials: JC
authors.lastname: Witteman
authors.forename: Eleftheria
authors.initials: E
authors.lastname: Zeggini
authors.forename: Guangju
authors.initials: G
authors.lastname: Zhai
authors.forename: M Carola
authors.initials: MC
authors.lastname: Zillikens
authors.forename: David
authors.initials: D
authors.lastname: Altshuler
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Caulfield
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Chanock
authors.forename: I Sadaf
authors.initials: IS
authors.lastname: Farooqi
authors.forename: Luigi
authors.initials: L
authors.lastname: Ferrucci
authors.forename: Jack M
authors.initials: JM
authors.lastname: Guralnik
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Hattersley
authors.forename: Frank B
authors.initials: FB
authors.lastname: Hu
authors.forename: Marjo-Riitta
authors.initials: MR
authors.lastname: Jarvelin
authors.forename: Markku
authors.initials: M
authors.lastname: Laakso
authors.forename: Vincent
authors.initials: V
authors.lastname: Mooser
authors.forename: Ken K
authors.initials: KK
authors.lastname: Ong
authors.forename: Willem H
authors.initials: WH
authors.lastname: Ouwehand
authors.forename: Veikko
authors.initials: V
authors.lastname: Salomaa
authors.forename: Nilesh J
authors.initials: NJ
authors.lastname: Samani
authors.forename: Timothy D
authors.initials: TD
authors.lastname: Spector
authors.forename: Tiinamaija
authors.initials: T
authors.lastname: Tuomi
authors.forename: Jaakko
authors.initials: J
authors.lastname: Tuomilehto
authors.forename: Manuela
authors.initials: M
authors.lastname: Uda
authors.forename: André G
authors.initials: AG
authors.lastname: Uitterlinden
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Wareham
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Deloukas
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Frayling
authors.forename: Leif C
authors.initials: LC
authors.lastname: Groop
authors.forename: Richard B
authors.initials: RB
authors.lastname: Hayes
authors.forename: David J
authors.initials: DJ
authors.lastname: Hunter
authors.forename: Karen L
authors.initials: KL
authors.lastname: Mohlke
authors.forename: Leena
authors.initials: L
authors.lastname: Peltonen
authors.forename: David
authors.initials: D
authors.lastname: Schlessinger
authors.forename: David P
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authors.lastname: Strachan
authors.forename: H-Erich
authors.initials: HE
authors.lastname: Wichmann
authors.forename: Mark I
authors.initials: MI
authors.lastname: McCarthy
authors.forename: Michael
authors.initials: M
authors.lastname: Boehnke
authors.forename: Inês
authors.initials: I
authors.lastname: Barroso
authors.forename: Gonçalo R
authors.initials: GR
authors.lastname: Abecasis
authors.forename: Joel N
authors.initials: JN
authors.lastname: Hirschhorn
mesh_terms: D000483:Alleles; D000886:Anthropometry; D015992:Body Mass Index; D001835:Body Weight / Q000235:genetics*; D002490:Central Nervous System / Q000502:physiology*; D015331:Cohort Studies; D018628:Gene Dosage; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D015201:Meta-Analysis as Topic; D009765:Obesity / Q000150:complications / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D040641:Quantitative Trait Loci / Q000235:genetics*; D019655:Quantitative Trait, Heritable