[Crohn's disease in association with IgA nephropathy].
Urological complications are not uncommon in Crohn's disease (CD). The most common manifestations are renal stones, enterovesical fistulas, and ureteral obstruction, but renal parenchymal disease has rarely been reported. IgA nephropathy, the most common form of primary glomerulonephritis, is usually isolated, but can be sometimes associated with chronic extrarenal disorders such as inflammatory bowel disease. We describe a case of 36 year-old man with CD associated with IgA nephropathy. He was diagnosed as CD 6 years ago and at that time, isolated proteinuria was observed. He presented recurrent proteinuria and elevation of creatinine level while he had been managed well with mesalamine and azathioprine. The renal biopsy was performed and IgA nephropathy (type IV) was diagnosed. Strict blood pressure control with angiotensin converting enzyme inhibitor and calcium channel blocker resulted in clinical improvement and normalization of serum creatinine level.
Lee
Ji Myoung
JM
Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Lee
Kang Moon
KM
Kim
Hyung Wook
HW
Chung
Woo Chul
WC
Paik
Chang Nyol
CN
Lee
Jeong Rok
JR
Choi
Yeong Jin
YJ
Yang
Jin Mo
JM
D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000963:Antimetabolites / Q000627:therapeutic use; D001379:Azathioprine / Q000627:therapeutic use; D001794:Blood Pressure; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D003113:Colonoscopy; D003424:Crohn Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D005922:Glomerulonephritis, IGA / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008297:Male; D019804:Mesalamine / Q000627:therapeutic use; D011507:Proteinuria / Q000175:diagnosis / Q000209:etiology
D000806:Angiotensin-Converting Enzyme Inhibitors; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000963:Antimetabolites; D002121:Calcium Channel Blockers; D019804:Mesalamine; D001379:Azathioprine