title: Diphenylprolinol silyl ether as a catalyst in an enantioselective, catalytic michael reaction for the formation of alpha,alpha-disubstituted alpha-amino acid derivatives.
abstract: Direct and enantioselective: Diphenylprolinol silyl ether was found to catalyze the direct, asymmetric Michael reaction of 4-substituted 2-aryl-2-oxazoline-5-one and alpha,beta-unsaturated aldehydes, affording the chiral alpha,alpha-disubstituted alpha-amino acid derivatives with excellent enantioselectivity.
authors.affiliation: Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan. hayashi@ci.kagu.tus.ac.jp
authors.forename: Yujiro
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Kazuki
authors.initials: K
authors.lastname: Obi
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Ohta
authors.forename: Daichi
authors.initials: D
authors.lastname: Okamura
authors.forename: Hayato
authors.initials: H
authors.lastname: Ishikawa
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D002384:Catalysis; D004987:Ethers / Q000737:chemistry*; D010080:Oxazoles / Q000737:chemistry; D011392:Proline / Q000031:analogs & derivatives* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D004987:Ethers; D010080:Oxazoles; C529940:diphenylprolinol silyl ether; D011392:Proline