title: [Case of intracerebral hemorrhage due to amphetamine abuse].
abstract: We report a case of intracranial hemorrhage due to amphetamine abuse in a young adult. A 34-year-old, confused woman was transferred to our emergency room with right hemiparesis and aphasia. CT at admission demonstrated intracerebral hemorrhage in the left frontal and parietal lobes, associated with subarachnoid hemorrhage. MRA shortly after admission revealed no intracerebral vascular anomaly. Cerebral angiography following admission showed irregularity of the vessel wall in the left anterior and middle cerebral arteries. Later, a toxicology screen test for urine was found to be positive for amphetamines and metamphetamines. These findings suggested that cerebral vasculitis and hypertensive surge induced by amphetamines caused intracranial and subarachnoid hemorrhage. Amphetamine abuse should always be considered as a cause of intracranial hemorrhage in young adults.
authors.affiliation: Department of Neurosurgery, Koshigaya Municipal Hospital, 10-47-1 Higashikoshigaya, Koshigaya-shi, Saitama 343-8577, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hara
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Fujii
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Ohno
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Tomita
authors.forename: Akira
authors.initials: A
authors.lastname: Tsunoda
authors.forename: Chikashi
authors.initials: C
authors.lastname: Maruki
authors.forename: Shigeo
authors.initials: S
authors.lastname: Kurokawa
mesh_terms: D000328:Adult; D000661:Amphetamine / Q000009:adverse effects*; D019969:Amphetamine-Related Disorders / Q000150:complications* / Q000175:diagnosis; D002533:Cerebral Angiography; D002543:Cerebral Hemorrhage / Q000139:chemically induced / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D018810:Magnetic Resonance Angiography; D013345:Subarachnoid Hemorrhage / Q000139:chemically induced / Q000175:diagnosis / Q000209:etiology; D014057:Tomography, X-Ray Computed; D020293:Vasculitis, Central Nervous System / Q000139:chemically induced
chemical_list: D000661:Amphetamine