title: The use of radiotherapy for the treatment of localized orbital amyloidosis.
abstract: OBJECTIVE
  To describe two patients with localized orbital amyloidosis and the response of their condition to surgical debulking followed by external beam radiotherapy.
  
  
  METHODS
  Retrospective noncomparative interventional case series.
  
  
  METHODS
  Stabilization or regression of orbital signs after treatment.
  
  
  METHODS
  Patients with biopsy-proven diagnosis of localized progressive orbital amyloidosis received 34 and 30 Gy fractionated external beam radiotherapy. The clinical case notes and histopathology for the two patients were reviewed.
  
  
  RESULTS
  A 69-year-old man with orbital amyloid deposition in association with localized MALT lymphoma had a marked improvement in orbital signs following surgical debulking and radiotherapy, with no recurrence over two years. A 59-year-old woman with localized orbital amyloidosis showed regression of disease after surgical debulking and radiotherapy, with no evidence of recurrence after six years of follow-up.
  
  
  CONCLUSIONS
  External beam radiotherapy following surgical debulking appears to halt the progression of localized orbital amyloidosis. Radiotherapy may be used in conjunction with surgical debulking of disease.
authors.affiliation: Department of Medical Oncology, St. Bartholomew's Hospital, London, UK.
authors.forename: Mandip
authors.initials: M
authors.lastname: Khaira
authors.forename: Antony
authors.initials: A
authors.lastname: Mutamba
authors.forename: George
authors.initials: G
authors.lastname: Meligonis
authors.forename: Geoffrey E
authors.initials: GE
authors.lastname: Rose
authors.forename: Piers N
authors.initials: PN
authors.lastname: Plowman
authors.forename: Helen
authors.initials: H
authors.lastname: O'Donnell
mesh_terms: D000368:Aged; D000686:Amyloidosis / Q000175:diagnosis / Q000532:radiotherapy* / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013508:Ophthalmologic Surgical Procedures; D009916:Orbital Diseases / Q000175:diagnosis / Q000532:radiotherapy* / Q000601:surgery; D020266:Radiotherapy, Conformal; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed