title: 3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymerase.
abstract: Isoquinoline-based non-nucleoside inhibitors of HCV NS5b RNA-dependent RNA-polymerase are described. The synthesis and structure-activity relationships are detailed, along with enzyme and cellular activity.
authors.affiliation: Roche Palo Alto LLC, Medicinal Chemistry, 3431 Hillview Avenue, MS: R6E-3 (R6W-120B), Palo Alto, CA 94304, USA. Than.Hendricks@Roche.com
authors.forename: Robert T
authors.initials: RT
authors.lastname: Hendricks
authors.forename: Stacey R
authors.initials: SR
authors.lastname: Spencer
authors.forename: James F
authors.initials: JF
authors.lastname: Blake
authors.forename: Jay B
authors.initials: JB
authors.lastname: Fell
authors.forename: John P
authors.initials: JP
authors.lastname: Fischer
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Stengel
authors.forename: Vincent J P
authors.initials: VJ
authors.lastname: Leveque
authors.forename: Sophie
authors.initials: S
authors.lastname: Lepogam
authors.forename: Sonal
authors.initials: S
authors.lastname: Rajyaguru
authors.forename: Isabel
authors.initials: I
authors.lastname: Najera
authors.forename: John A
authors.initials: JA
authors.lastname: Josey
authors.forename: Steven
authors.initials: S
authors.lastname: Swallow
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D007546:Isoquinolines / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D012324:RNA-Dependent RNA Polymerase / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D007546:Isoquinolines; D017361:Viral Nonstructural Proteins; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase