How to shape cells and influence polarized protein trafficking.
Posttranslational modifications of tubulin likely generate the functional diversity of microtubules. In this issue of Developmental Cell, Loktev and colleagues (2008) describe a novel protein BBIP10 with dual roles: it is required for ciliogenesis as well as acetylation and stabilization of microtubules.
Diaz-Font
Anna
A
Molecular Medicine Unit, Institute of Child Health, University College London, London, UK.
Beales
Philip L
PL
D000107:Acetylation; D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry* / Q000378:metabolism; D002696:Chlamydomonas / Q000378:metabolism; D006801:Humans; D008239:Lysine / Q000737:chemistry; D008870:Microtubules / Q000378:metabolism; D008954:Models, Biological; D009842:Oligopeptides; D010446:Peptide Fragments; D011499:Protein Processing, Post-Translational; D021381:Protein Transport / Q000235:genetics*; D015398:Signal Transduction; D013768:Tetrahymena / Q000378:metabolism; D029961:Zebrafish Proteins / Q000737:chemistry* / Q000378:metabolism
D002352:Carrier Proteins; D009842:Oligopeptides; D010446:Peptide Fragments; D029961:Zebrafish Proteins; C534297:bbip1 protein, zebrafish; C085462:benzoylbenzoyl-troponin I inhibitory peptide (104-115); D008239:Lysine