title: Histomorphometric analysis of HA-coated implants interface with irradiated and nonirradiated bone.
abstract: OBJECTIVE
  The purpose of the present study was to investigate whether osseointegration of HA-coated implants can be affected by irradiation.
  
  
  METHODS
  A single dose of 15 Gy was applied to the right tibia of 5 rabbits and the left tibia was not irradiated and used as control. After 3 months, the animals were killed and the quantification of the implant-bone contact surfaces was performed using scanning electron micrographs of the resin sections containing the implants in the irradiated and nonirradiated bones. After the healing period, all implants were stable.
  
  
  RESULTS
  The results show a mean percentage of bone-implant contact of 45.52% in the irradiated tissue and 47.56% in the nonirradiated tissue, with no statistic significant difference (P > 0.05).
  
  
  CONCLUSIONS
  In conclusion, radiotherapy may not interfere with osseointegration process around HA-coated implants in rabbit cortical bone.
authors.affiliation: Department of Oral Implantology, School of Dentistry, Unigranrio University, Duque de Caxias, Brazil. vidigaljr@globo.com
authors.forename: Guaracilei Maciel
authors.initials: GM
authors.lastname: Vidigal
authors.forename: Andrea Ferreira
authors.initials: AF
authors.lastname: Crispino
authors.forename: Mario
authors.initials: M
authors.lastname: Groisman
authors.forename: Gloria
authors.initials: G
authors.lastname: de Almeida Soares
mesh_terms: D000818:Animals; D016723:Bone Remodeling / Q000528:radiation effects*; D020099:Coated Materials, Biocompatible; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D017267:Dental Prosthesis Design; D017886:Durapatite; D005260:Female; D016348:Osseointegration; D010025:Osteoradionecrosis; D011817:Rabbits; D013977:Tibia
chemical_list: D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D017886:Durapatite