Peripheral insulin-like growth factor-I produces antidepressant-like behavior and contributes to the effect of exercise.
Growth factors in the brain are important to depression and it's treatment and we assessed the ability of peripherally administered insulin-like growth factor-I (IGF-I) to influence behavior related to depression. We found that mice that received chronic IGF-I treatment showed antidepressant-like behavior in forced-swim and novelty-induced hypophagia (NIH) tests and increased sucrose consumption after chronic mild unpredictable stress exposure. Additionally, peripheral anti-IGF-I administration blocked exercise-induced antidepressant effects in the forced-swim test (FST). These results support the functional relevance of neurotrophic mechanisms to depression and extend this idea to include neurotrophic factors in the periphery.
Duman
Catharine H
CH
Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA. catharine.duman@yale.edu
Schlesinger
Lee
L
Terwilliger
Rosemarie
R
Russell
David S
DS
Newton
Samuel S
SS
Duman
Ronald S
RS
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics / Q000378:metabolism; D003863:Depression / Q000188:drug therapy* / Q000523:psychology; D004797:Enzyme-Linked Immunosorbent Assay; D015444:Exercise / Q000523:psychology; D006801:Humans; D007074:Immunoglobulin G / Q000494:pharmacology; D017403:In Situ Hybridization; D007279:Injections, Subcutaneous; D007334:Insulin-Like Growth Factor I / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000502:physiology; D013312:Stress, Physiological / Q000187:drug effects*; D013550:Swimming / Q000502:physiology; D013997:Time Factors
D000928:Antidepressive Agents; D019208:Brain-Derived Neurotrophic Factor; D007074:Immunoglobulin G; D007334:Insulin-Like Growth Factor I