IL-22 in mucosal immunity.
Recent studies in infectious disease and autoimmune disease models have revealed that interleukin (IL)-22 might have both proinflammatory and anti-inflammatory functions. There is, however, lack of evidence for IL-22 directly repressing immune responses of leukocytes. We propose that IL-22 promotes innate immunity of tissues, as well as repairing and healing mechanisms during inflammation. Consequently, the restoration of tissue homeostasis helps to attenuate the inflammatory responses involving various immune cells.
Ouyang
W
W
Department of Immunology, South San Francisco, California, USA. ouyang@gene.com
Valdez
P
P
D000818:Animals; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D018928:Immunity, Mucosal / Q000276:immunology*; D007249:Inflammation / Q000276:immunology; D007378:Interleukins / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D000097043:Interleukin-22
D007378:Interleukins; D000097043:Interleukin-22