title: Steroid-responsive facial eruption with cornoid lamellae--a possible new entity.
abstract: The histopathologic presence of a cornoid lamella is often associated with a diagnosis of porokeratosis. However, this feature is not pathognomonic for porokeratosis and can be found in a number of other dermatologic conditions, which include seborrheic keratosis, verruca vulgaris, actinic keratosis, squamous-cell carcinoma in situ, basal-cell carcinoma, milia, and scar. Notably, the etiology of none of these entities is inflammatory. Wade and Ackerman consider cornoid lamellation to be a distinctive histopathologic reaction pattern that reflects the disordered progression of epidermal cells during cornification. As such, this pattern is not specific for any given disease process. We report a case in which the lesions appeared inflammatory clinically as well as histopathologically, did not resemble porokeratosis despite the presence of cornoid lamellae, and responded to topical glucocorticoids.
authors.affiliation: Department of Dermatology, New York University, USA.
authors.forename: Hien
authors.initials: H
authors.lastname: Tran
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Bossenbroek
authors.forename: Karla
authors.initials: K
authors.lastname: Rosenman
authors.forename: Shane A
authors.initials: SA
authors.lastname: Meehan
authors.forename: Miguel
authors.initials: M
authors.lastname: Sanchez
authors.forename: Stephen
authors.initials: S
authors.lastname: Prystowsky
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005148:Facial Dermatoses / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D005938:Glucocorticoids / Q000627:therapeutic use; D006526:Hepatitis C / Q000188:drug therapy; D006801:Humans; D007249:Inflammation; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols; D017499:Porokeratosis / Q000175:diagnosis; D011994:Recombinant Proteins; D012536:Scalp Dermatoses / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D017444:Skin Diseases, Papulosquamous / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*
chemical_list: D000893:Anti-Inflammatory Agents; D000998:Antiviral Agents; D005938:Glucocorticoids; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; C417083:peginterferon alfa-2b