title: Economic impact of a rotavirus vaccine in Brazil.
abstract: The study was done to evaluate the cost-effectiveness of a national rotavirus vaccination programme in Brazilian children from the healthcare system perspective. A hypothetical annual birth-cohort was followed for a five-year period. Published and national administrative data were incorporated into a model to quantify the consequences of vaccination versus no vaccination. Main outcome measures included the reduction in disease burden, lives saved, and disability-adjusted life-years (DALYs) averted. A rotavirus vaccination programme in Brazil would prevent an estimated 1,804 deaths associated with gastroenteritis due to rotavirus, 91,127 hospitalizations, and 550,198 outpatient visits. Vaccination is likely to reduce 76% of the overall healthcare burden of rotavirus-associated gastroenteritis in Brazil. At a vaccine price of US$ 7-8 per dose, the cost-effectiveness ratio would be US$ 643 per DALY averted. Rotavirus vaccination can reduce the burden of gastroenteritis due to rotavirus at a reasonable cost-effectiveness ratio.
authors.affiliation: Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA. dagnaconstenla@yahoo.com
authors.forename: Dagna O
authors.initials: DO
authors.lastname: Constenla
authors.forename: Alexandre C
authors.initials: AC
authors.lastname: Linhares
authors.forename: Richard D
authors.initials: RD
authors.lastname: Rheingans
authors.forename: Lynn R
authors.initials: LR
authors.lastname: Antil
authors.forename: Eliseu A
authors.initials: EA
authors.lastname: Waldman
authors.forename: Luiz J
authors.initials: LJ
authors.lastname: da Silva
mesh_terms: D001938:Brazil; D002675:Child, Preschool; D015331:Cohort Studies; D003362:Cost-Benefit Analysis / Q000706:statistics & numerical data; D005260:Female; D005759:Gastroenteritis / Q000191:economics* / Q000517:prevention & control; D006801:Humans; D007223:Infant; D008297:Male; D012401:Rotavirus / Q000187:drug effects; D012400:Rotavirus Infections / Q000191:economics* / Q000517:prevention & control; D022243:Rotavirus Vaccines / Q000191:economics*
chemical_list: D022243:Rotavirus Vaccines