A fluorescence detection scheme for ultra large molecules after gas phase separation.
A system was proposed to remove the upper mass limitation of mass spectrometry. In present study, ultra large molecules were separated in the gas phase by mass analyzer after electrospray ionization. Instead of conventional detection with electron multiplier, a laser-induced-fluorescence detection scheme was applied. The instrument sensitivity is independent of molecular weight, but related to the spectroscopic properties of the fluorophores presented by the large biomolecules.
He
Jian
J
Chemistry Division, MS K484, Los Alamos National Laboratory, Los Alamos, NM 87544, USA.
Zhong
Wenwan
W
Tang
Aijun
A
Yan
Xiaomei
X
Lewis
Cris
C
Majidi
Vahid
V
Hang
Wei
W