title: Does low molecular weight heparin impair anastomotic wound healing?
abstract: BACKGROUND
  Enoxaparin is an important molecule which had been using in prophylaxis and treatment of deep venous thrombosis. Also, it is showed that it prevents postsurgical peritoneal adhesions in rats. It is aimed to evaluate its effects on gastrointestinal wound healing.
  
  
  METHODS
  Thirty Wistar albino rats were divided into three groups as control, subcutan, and intraperitoneal enoxaparin groups. Left colon anastomoses were performed. On postoperative seventh day, anastomotic healing was evaluated by measuring anastomotic bursting pressure, tissue hydroxyproline levels, and histopathological examination.
  
  
  RESULTS
  The anastomotic bursting pressure was highest in subcutan enoxaparin group (p < 0.001), intraperitoneal enoxaparin group (p < 0.01) came the second, and the control group has the worst value. The hydroxyproline results were found nearly similar to the bursting pressure values (subcutan (p < 0.001) > intraperitoneal (p < 0.05) > control). Neovascularization in subcutan group (p < 0.001) has a statistically significant difference to other groups.
  
  
  CONCLUSIONS
  Enoxaparin did not interfere with colonic anastomotic resistance but improved the intestinal wound healing.
authors.affiliation: General Surgery Department, Ankara Ataturk Teaching and Research Hospital, Askaabat Cad. Eser Sitesi B Blok 3.Giris, Daire:11 Bahcelievler, 06490, Ankara, Turkey. dreergul@gmail.com
authors.forename: Emre
authors.initials: E
authors.lastname: Ergul
authors.forename: Yigit Mehmet
authors.initials: YM
authors.lastname: Ozgun
authors.forename: Gulten
authors.initials: G
authors.lastname: Kiyak
authors.forename: Gonca
authors.initials: G
authors.lastname: Barit Ozgun
authors.forename: Birol
authors.initials: B
authors.lastname: Korukluoglu
authors.forename: Ahmet
authors.initials: A
authors.lastname: Kusdemir
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D017984:Enoxaparin / Q000494:pharmacology*; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D006909:Hydroxyproline; D007422:Intestines / Q000601:surgery; D051381:Rats; D017208:Rats, Wistar; D013529:Surgical Wound Dehiscence / Q000517:prevention & control; D000267:Tissue Adhesions / Q000517:prevention & control; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D017984:Enoxaparin; D005343:Fibrinolytic Agents; D006909:Hydroxyproline