Applying mouse complex-trait resources to behavioural genetics.
Studies of the genetic basis of behaviour in mice are at a turning point. Soon, new resources will enable the behavioural function of all genes to be tested and the networks of genes, messenger RNAs and proteins involved in a particular behaviour to be identified. Using these resources, scientists will be able to analyse mouse behaviour at an unprecedented level of detail. Interpreting the new data, however, will require a shift in focus from gene-based approaches to network-based approaches.
Flint
Jonathan
J
Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK. jf@well.ox.ac.uk
Mott
Richard
R
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D019295:Computational Biology; D005824:Genetics, Behavioral / Q000379:methods*; D051379:Mice; D018345:Mice, Knockout; D016296:Mutagenesis; D010641:Phenotype