title: [Complaints under analgesics: the difficult interpretation by older patients].
abstract: BACKGROUND
  Older patients, particularly those with multimorbidity, complain about many symptoms which also occur under analgesics (especially with opioids). The goals of the study were to quantify symptoms and discuss the relationships to analgesics, pain, multimorbidity, function, age and gender.
  
  
  METHODS
  On admittance to geriatric hospital, 1700 consecutive inpatients were questioned about symptoms typically of side-effects of analgesics and pain. Additionally medication including analgesics, activities of daily living, orientation, age, gender and morbidity were recorded.
  
  
  RESULTS
  Of the patients, 1,418 (mean age 80.9 years) could answer questions about symptoms. Disturbance of sleep (n=664, 46.8%), pain (n=609, 43.0%), low appetite (551, 37.4%), dizziness (482, 34%), tiredness (331, 19.7%), constipation (236, 16.6%) and problems of urination (213, 12.7%) were indicated most frequently. Univariate analysis showed the well known correlations of analgesics and symptoms to be dependent on dose and substances. However, using a multivariate model, analgesics lost the significance for the symptoms with some exceptions. Pain intensity, duration of pain and gender differences became more important. Vomiting, dry mouth, and problems with urination correlated with low levels of activities of daily living. Increasing morbidity and cognitive deficits were not important for many symptoms.
  
  
  CONCLUSIONS
  Our results underline the difficult interpretation of symptoms as a side-effect of analgesic treatment in older patients. Pain and gender differences have to be considered. The recommendation to carefully record symptoms before analgesic treatment is supported by our results.
authors.affiliation: Diakonie-Krankenhaus, Speyererstr. 91-93, 68163, Mannheim, Deutschland. m.schuler@diako-mannheim.de
authors.forename: M
authors.initials: M
authors.lastname: Schuler
authors.forename: D
authors.initials: D
authors.lastname: Razus
authors.forename: P
authors.initials: P
authors.lastname: Oster
mesh_terms: D000203:Activities of Daily Living / Q000145:classification; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000700:Analgesics / Q000008:administration & dosage / Q000009:adverse effects*; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects*; D015897:Comorbidity; D004347:Drug Interactions; D005260:Female; D016330:Frail Elderly; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement / Q000187:drug effects; D017060:Patient Satisfaction; D012307:Risk Factors
chemical_list: D000700:Analgesics; D000701:Analgesics, Opioid