[Study of the interactions between oligosaccharides involved in the cell adhesion. Example of the Lewis(x) trisaccharide].
Nature often chooses weak molecular interactions for playing important role in cellular recognition and adhesion. These interactions involve particularly oligosaccharides, which are the structural elements present at the most exterior surface of the cell. Three oligosaccharides were prepared for study of the interaction by vesicle micromanipulation technique. This study allowed us to measure directly, for the first time, a carbohydrate-carbohydrate interaction.
Zhang
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Laboratoire de chimie organique (UMR CNRS 7611), université Pierre-et-Marie-Curie-Paris 6, Paris, France. yongmin.zhang@upmc.fr
D000818:Animals; D002122:Calcium Chloride / Q000494:pharmacology; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D002448:Cell Adhesion / Q000187:drug effects; D045744:Cell Line, Tumor / Q000187:drug effects; D002518:Ceramides / Q000737:chemistry / Q000494:pharmacology; D004347:Drug Interactions; D006017:Glycolipids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D007785:Lactose / Q000737:chemistry; D016256:Lewis X Antigen / Q000031:analogs & derivatives; D008081:Liposomes / Q000737:chemistry; D008561:Membrane Fusion / Q000187:drug effects; D051379:Mice; D008846:Micromanipulation; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013499:Surface Properties / Q000187:drug effects; D018243:Teratocarcinoma / Q000473:pathology; D014312:Trisaccharides / Q000737:chemistry / Q000494:pharmacology*
D002518:Ceramides; D006017:Glycolipids; D016256:Lewis X Antigen; D008081:Liposomes; D009844:Oligosaccharides; D014312:Trisaccharides; C110530:galactosyl-(1,4)-fucopyranosyl-(1,3)-N-acetylglucosamine; D007785:Lactose; D002122:Calcium Chloride