Continued complete remission without systemic therapy for isolated testicular relapse after bone marrow transplantation in a boy with acute lymphoblastic leukemia.
ITR after BMT in cases of acute lymphoblastic leukemia is relatively rare. Treatment for ITR after BMT generally consists of a combination of local irradiation, orchiectomy, and systemic chemotherapy. However, the effectiveness of these modalities has not been established. Both irradiation and systemic chemotherapy including a second transplantation would result in additional toxicity. In this report we describe a boy with ITR 91 months after BMT who has remained in complete remission more than two yr after a unilateral orchiectomy. We did not treat this patient with systemic chemotherapy, as his ITR developed very late. Our experience suggests that orchiectomy alone is a reasonable option for very late ITR after BMT.
Kodama
Yuichi
Y
Department of Pediatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. yuichik@m.kufm.kagoshima-u.ac.jp
Okamoto
Yasuhiro
Y
Ijichi
Osamu
O
Shinkoda
Yuichi
Y
Nishikawa
Takuro
T
Tanabe
Takayuki
T
Yoshioka
Takako
T
Tashiro
Yukie
Y
Mougi
Hiroyuki
H
Kawano
Yoshifumi
Y
D016026:Bone Marrow Transplantation / Q000379:methods*; D002648:Child; D006801:Humans; D007223:Infant; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D012008:Recurrence; D012074:Remission Induction; D013736:Testicular Neoplasms / Q000175:diagnosis* / Q000556:secondary; D013737:Testis / Q000601:surgery; D016896:Treatment Outcome