title: Putting a KAP on transcription and stress.
abstract: Chromatin regulation plays an important role in brain development and the generation of phenotypic diversity. In this issue of Neuron, Jakobsson et al. find that disruption in neurons of KAP1, a key component of transcriptional repressor complexes in the brain, results in increased anxiety-like behavior and sensitivity to stress.
authors.affiliation: Department of Psychiatry, Columbia University, New York, NY 10032, USA.
authors.forename: Mark D
authors.initials: MD
authors.lastname: Alter
authors.forename: Rene
authors.initials: R
authors.lastname: Hen
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology*; D012097:Repressor Proteins / Q000235:genetics / Q000502:physiology*; D013315:Stress, Psychological / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D014158:Transcription, Genetic / Q000502:physiology*; D000076183:Tripartite Motif-Containing Protein 28
chemical_list: D009687:Nuclear Proteins; D012097:Repressor Proteins; C103190:Trim28 protein, mouse; D000076183:Tripartite Motif-Containing Protein 28