A catheter based chronic porcine model of post-infarct dilated heart failure.
OBJECTIVE
New surgical treatments for post-infarct antero-septal myocardial akinesia have been developed but evaluation of their mode of function is hampered by absence of suitable large animal heart failure models. We aimed to develop and evaluate a human compatible model for chronic post-infarct left ventricular (LV) remodeling.


METHODS
Fourteen female 50 kg pigs underwent catheter-based coronary artery occlusion (one hour) distal to the first LAD diagonal. Eight weight- and age-matched healthy animals served as controls. LV geometry and function were assessed after 6 weeks with cardiovascular MRI.


RESULTS
All animals recovered from interventions. Three animals died during follow-up. All intervention animals had antero-septal akinetic infarcts (mean 26.5% of LV myocardium). Intervention animals had significantly increased end-diastolic and end-systolic volumes, and decreased stroke volume, ejection fraction and cardiac output. Detailed functional analysis showed significant systolic- and diastolic-dysfunction in intervention animals.


CONCLUSIONS
We have established a feasible model of post-infarct LV remodeling, which accurately simulates human pathogenesis and pathophysiology. The model may be suitable for evaluation of novel surgical alleviations for heart failure.
Brødløs
Hans Kristian
HK
Department of Cardiothoracic & Vascular Surgery T and the Institute of Clinical Medicine, Aarhus University Hospital, Skejby, Denmark.
Bramsen
Morten B
MB
Agger
Peter
P
Jensen
Henrik
H
Bjerre
Marianne
M
Ringgaard
Steffen
S
Wierup
Per
P
Nielsen
Sten Lyager
SL
Hasenkam
J Michael
JM
Smerup
Morten
M
D000818:Animals; D006328:Cardiac Catheterization / Q000009:adverse effects*; D002302:Cardiac Output; D004195:Disease Models, Animal; D005240:Feasibility Studies; D005260:Female; D006333:Heart Failure / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D009203:Myocardial Infarction / Q000150:complications* / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D009206:Myocardium / Q000473:pathology; D015203:Reproducibility of Results; D013318:Stroke Volume; D013552:Swine; D013997:Time Factors; D018487:Ventricular Dysfunction, Left / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D020257:Ventricular Remodeling