title: Coexistence of gastrointestinal stromal tumor (GIST) of the rectum and adenocarcinoma of the prostate in a patient with familial GIST.
abstract: BACKGROUND
  Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal system. The rectum is a rare location for GIST. Prostate adenocarcinoma is the most common malignancy in geriatric men. Rarely, rectal GIST mimics prostate pathologies.
  
  
  METHODS
  We describe a 58-year-old male patient who was admitted with signs and symptoms of prostatism. A presumptive diagnosis of primary prostate sarcoma was made based on imaging studies and a trucut biopsy. Removal of the mass compressing both the prostate and the rectum revealed the final diagnosis of synchronous prostate adenocarcinoma and high-grade GIST originating from the rectum. The patient also had a family history of GIST.
  
  
  CONCLUSIONS
  According to our knowledge, there are 5 more reported cases of rectal GIST, which were misdiagnosed as prostate malignancy. Rectal GIST may simulate prostate carcinoma clinically, and should always be kept in mind in the differential diagnosis of prostate pathologies.
authors.affiliation: Department of Medical Oncology, Gazi University Faculty of Medicine, Ankara, Turkey.
authors.forename: Emel
authors.initials: E
authors.lastname: Yaman
authors.forename: Ugur
authors.initials: U
authors.lastname: Coskun
authors.forename: Mustafa
authors.initials: M
authors.lastname: Benekli
authors.forename: Sinan
authors.initials: S
authors.lastname: Sozen
authors.forename: Deniz
authors.initials: D
authors.lastname: Yamac
authors.forename: Suleyman
authors.initials: S
authors.lastname: Buyukberber
authors.forename: Banu
authors.initials: B
authors.lastname: Ozturk
authors.forename: Ali Osman
authors.initials: AO
authors.lastname: Kaya
authors.forename: Ramazan
authors.initials: R
authors.lastname: Yildiz
authors.forename: Ekmel
authors.initials: E
authors.lastname: Tezel
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000628:therapy; D003937:Diagnosis, Differential; D046152:Gastrointestinal Stromal Tumors / Q000151:congenital* / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000628:therapy; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000628:therapy; D012004:Rectal Neoplasms / Q000175:diagnosis* / Q000628:therapy