An efficient synthesis of quinolines derivatives promoted by a room temperature ionic liquid at ambient conditions under ultrasound irradiation via the tandem addition/annulation reaction of o-aminoaryl ketones with alpha-methylene ketones.
The condensation reaction involving an o-aminoaryl ketones with alpha-methylene ketones via the tandem addition/annulation reaction by the ionic liquid of [Hbim][BF4] (IL) as a solvent with methanol as co-solvent at room temperature under ultrasound irradiation afforded the corresponding quinolines derivatives in excellent yields. The use of ionic liquid and ultrasound, which promoted this protocol under room temperature without the requirement of any added catalyst. Quinoline derivatives are important and have a potential use as special biological drug in medicine.
Heravi
Mohammad Reza Poor
MR
Department of Chemistry, Payame Noor University (Pnu), Abhar, Iran. heravimr@yahoo.com
D001880:Boranes / Q000737:chemistry*; D052578:Ionic Liquids / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013010:Sonication; D013237:Stereoisomerism; D013696:Temperature; D014465:Ultrasonics
D001880:Boranes; D052578:Ionic Liquids; D007659:Ketones; D011804:Quinolines