CD103+ GALT DCs promote Foxp3+ regulatory T cells.
There is evidence that Foxp3(+) regulatory T (T(R)) cells contribute to intestinal homeostasis and that deficiencies in this population can lead to chronic intestinal inflammation. Here, we review recent studies that demonstrate that the gut is a site of peripheral generation of T(R) cells. Functionally specialized gut dendritic cell populations promote T(R) cells through a transforming growth factor-beta and retinoic acid-dependent mechanism. Gut-driven T(R) cells may represent a tissue-specific mechanism to broaden the repertoire of T(R) cells focussed on the gut.
Siddiqui
K R R
KR
Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
Powrie
F
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D000818:Animals; D015703:Antigens, CD / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D051858:Forkhead Transcription Factors / Q000276:immunology*; D006801:Humans; D039001:Integrin alpha Chains / Q000276:immunology*; D007422:Intestines / Q000276:immunology*; D008221:Lymphoid Tissue / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D015703:Antigens, CD; D051858:Forkhead Transcription Factors; D039001:Integrin alpha Chains; C091367:alpha E integrins