title: Plasminogen activator inhibitor-1 gene 4G/5G polymorphism in Turkish children with asthma and allergic rhinitis.
abstract: Plasminogen activator inhibitor (PAI-1) has an essential role in tissue remodeling after inflammation. Recent literature revealed only one study evaluating PAI-1 4G/5G gene polymorphism in children with asthma and none in children with allergic rhinitis. We aimed to investigate distribution of PAI-1 4G/5G polymorphism in a group of Turkish children with asthma and allergic rhinitis and compare these findings with those obtained in normal peers. Patients with physician-diagnosed asthma (n = 106) and allergic rhinitis (n = 99) and 83 healthy peers were included in this study. We evaluated PAI-1 4G/5G polymorphism genotype as well as the possible association between PAI-1 4G/5G polymorphism and pulmonary function tests, serum total immunoglobulin E (IgE), total eosinophil count, and skin-prick test positivity in our study. The prevalence of the 4G allele significantly exceeded the values found in the controls both in patients with asthma (p = 0.001) and in patients with allergic rhinitis (p = 0.002). Interestingly, comparison of asthmatic patients revealed that mean baseline percent forced expiratory volume in 1 second and forced vital capacity were significantly higher in patients who bear 5G/5G genotype than in those who have 4G/4G or 4G/5G genotypes. No statistically significant relationship were found between PAI-1 polymorphism and total serum IgE levels, total eosinophil count, or selected skin test responses to aeroallergens. Our study suggests that Turkish children with asthma or allergic rhinitis have a higher prevalence of PAI-1 4G allele compared with their healthy peers.
authors.affiliation: Department of Pediatric Allergy, Baskent University Faculty of Medicine, Ankara, Turkey. ozlemozbek@superonline.com
authors.forename: Ozlem Yilmaz
authors.initials: OY
authors.lastname: Ozbek
authors.forename: F Belgin
authors.initials: FB
authors.lastname: Ataç
authors.forename: Ersin
authors.initials: E
authors.lastname: Ogus
authors.forename: Namik
authors.initials: N
authors.lastname: Ozbek
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000453:epidemiology / Q000235:genetics*; D002452:Cell Count; D002648:Child; D004804:Eosinophils / Q000276:immunology / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D011110:Polymorphism, Genetic; D012129:Respiratory Function Tests; D012221:Rhinitis, Allergic, Perennial / Q000453:epidemiology / Q000235:genetics*; D006255:Rhinitis, Allergic, Seasonal / Q000453:epidemiology / Q000235:genetics*; D012882:Skin Tests; D014421:Turkey
chemical_list: D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human; D007073:Immunoglobulin E