Mitochondrial DNA haplogroups J and K are not protective for Parkinson's disease in the Australian community.
MtDNA haplogroups J and K have been associated with a decreased risk of developing Parkinson's disease (PD). To confirm this finding, we compared the distribution of mtDNA haplogroups J and K in a large sample of Australian patients with PD (n = 890) to population-based controls (n = 3,491). We assigned subjects to haplogroups J or K using standard PCR/RFLP techniques. Of the 890 subjects with PD, 10.6% were haplogroup J (95% CI 8.6-12.8, n = 94) and 7.1% were haplogroup K (95% CI 5.5-8.9, n = 63). In our controls, 10.2% belonged to haplogroup J (95% CI 9.2-11.2, n = 356), and 7.8% were in haplogroup K (95% CI 6.9-8.7, n = 272). There was no significant difference in the prevalence of mtDNA haplogroup J or K in PD patients compared to population-based controls. Our findings indicate that mtDNA haplogroups J and K are not associated with a lower risk of PD.
Mehta
Prachi
P
Department of Neurology and Neurogenetics, Kolling Institute, Royal North Shore Hospital and University of Sydney, Sydney, Australia.
Mellick
George D
GD
Rowe
Dominic B
DB
Halliday
Glenda M
GM
Jones
Michael M
MM
Manwaring
Neil
N
Vandebona
Himesha
H
Silburn
Peter A
PA
Wang
Jie Jin
JJ
Mitchell
Paul
P
Sue
Carolyn M
CM
D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D001315:Australia / Q000453:epidemiology; D016022:Case-Control Studies; D004272:DNA, Mitochondrial / Q000145:classification / Q000235:genetics*; D005060:Europe / Q000208:ethnology; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D044465:White People / Q000235:genetics
D004272:DNA, Mitochondrial