title: Targeted therapeutic RNases (ImmunoRNases).
abstract: Immunotoxins combining antibody specificity with bacterial or plant toxins are limited by their strong immunogenicity and non-specific toxicity. Ribonucleases of the RNase A protein superfamily provide a solution to address these issues because they show potent antineoplastic activity on cell internalization but do not show appreciable immunogenicity or non-specific toxicity. Their therapeutic value is demonstrated by RNase derived from the frog (Rana pipiens), Onconase (ONC, Alfacell, Inc., New Jersey, USA), the first and only RNase being evaluated in clinical trials at present. Conjugation or fusion of RNases to tumor specific antibodies is a promising approach to further boost tumor cell killing of these compounds. This review focuses on 'targeted RNases/ImmunoRNases' as promising novel anticancer therapeutics.
authors.affiliation: Technische Universität Braunschweig, Braunschweig, Germany. th.schirrmann@tu-bs.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Schirrmann
authors.forename: Jürgen
authors.initials: J
authors.lastname: Krauss
authors.forename: Michaela A E
authors.initials: MA
authors.lastname: Arndt
authors.forename: Susanna M
authors.initials: SM
authors.lastname: Rybak
authors.forename: Stefan
authors.initials: S
authors.lastname: Dübel
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006801:Humans; D000922:Immunotoxins / Q000627:therapeutic use; D017730:Ki-1 Antigen / Q000276:immunology; D011355:Prodrugs / Q000627:therapeutic use; D011993:Recombinant Fusion Proteins / Q000627:therapeutic use; D012259:Ribonuclease, Pancreatic / Q000627:therapeutic use; D012260:Ribonucleases / Q000627:therapeutic use*; D051918:Sialic Acid Binding Ig-like Lectin 2 / Q000276:immunology
chemical_list: D000970:Antineoplastic Agents; D000922:Immunotoxins; D017730:Ki-1 Antigen; D011355:Prodrugs; D011993:Recombinant Fusion Proteins; D051918:Sialic Acid Binding Ig-like Lectin 2; D012260:Ribonucleases; C046366:angiogenin; D012259:Ribonuclease, Pancreatic; C058703:ranpirnase