Dichotomy between postprandial glucose and lipid profiles in adults with cystic fibrosis: a pilot study.
BACKGROUND
Cystic fibrosis (CF) patients present a high incidence of glucose tolerance abnormalities. Altered insulin secretion combined with recommended high-fat intake could be associated with dysregulation of glucose and lipid metabolism. We examined postprandial glucose and lipid profiles during an oral glucose tolerance test (OGTT) and following a standardized high-fat test meal (TM).


METHODS
Sixteen CF patients with normal glucose tolerance (NGT) or CF-related diabetes (CFRD) and 16 controls underwent a 4 h OGTT and a TM. We then measured plasma glucose, insulin, free fatty acid (FFA) and triglyceride (TG) concentrations.


RESULTS
CF patients presented higher glucose excursion compared to controls after the OGTT and TM. However, in CF patients, this excursion was significantly reduced in both amplitude and length after the TM. The TM provoked a comparable increase in TG levels in both groups whereas they remained stable during the OGTT. FFAs were suppressed similarly in both groups after both challenges.


CONCLUSIONS
CF is associated with abnormal glucose excursion in the presence of relatively normal lipid excursion. The rapid normalization of glucose values after a mixed meal should be further explored and, if confirmed, might have significant implications for CFRD diagnostic.
Hammana
I
I
Diabetes and Metabolic Diseases Research Group, Research Centre hospitalier de l'Université de Montréal (CHUM) - Hôtel-Dieu, QC, Canada.
Coderre
L
L
Potvin
S
S
Costa
M
M
Berthiaume
Y
Y
Lavoie
A
A
Chiasson
J-L
JL
Levy
E
E
Rabasa-Lhoret
R
R
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D016022:Case-Control Studies; D003550:Cystic Fibrosis / Q000097:blood* / Q000150:complications; D003920:Diabetes Mellitus / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000150:complications / Q000175:diagnosis; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood*; D008297:Male; D010865:Pilot Projects; D019518:Postprandial Period; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D008055:Lipids; D014280:Triglycerides