Role of Programmed Cell Death in the Immunopathogenesis of Sepsis.
Apoptosis is an important mechanism during the immunopathogenesis of sepsis. Early programmed cell death of lymphocytes substantially impairs innate and adaptive immunity reducing the capacity to ward off the invading pathogen. Apoptosis of parenchymal cells (e.g. in the lung, liver and gut) may also promote organ failure and death. Several experimental therapeutic strategies have now been developed to beneficially influence these mechanisms; however, their potential clinical benefit is yet to be evaluated.
Perl
Mario
M
Division of Surgical Research, Department of Surgery, Rhode Island Hospital/ Brown University, School of Medicine, Providence, RI 02903.
Chung
Chun-Shiang
CS
Swan
Ryan
R
Ayala
Alfred
A