title: [Trospium chloride in combined treatment of females with genital prolapse and overactive urinary bladder].
abstract: The trial of efficacy of trospium chloride (TC) in a dose of 45 mg/day in females with overactive bladder (OAB) symptoms preserved after genital prolapse (GP) surgical correction included 28 females (age 55-82, mean age 68.07 +/- 12 years). GP was corrected by means of vaginal hysterectomy and anterior colporraphy. Treatment results were assessed 3 months after surgery basing on urine diary. Overall TC efficacy reached 82%. Symptoms attenuated in patients with and without detrusor overactivity: voiding frequency reduced by 31 and 24%, imperative voidings reduced by 26 and 8%, mean urine volume rose by 28 and 19%, respectively. Side effects were mild. TC demonstrated good efficacy in OAB patients, it noticeably improved quality of life.
authors.forename: M e
authors.initials: Me
authors.lastname: Shkol'nikov
authors.forename: E B
authors.initials: EB
authors.lastname: Mazo
authors.forename: G G
authors.initials: GG
authors.lastname: Krivoborodov
authors.forename: Iu E
authors.initials: IuE
authors.lastname: Dobrokhotova
authors.forename: M M
authors.initials: MM
authors.lastname: Kaĭfadzhan
authors.forename: L V
authors.initials: LV
authors.lastname: Fandeeva
authors.forename: R F
authors.initials: RF
authors.lastname: Nurullin
authors.forename: M S
authors.initials: MS
authors.lastname: Zhdanova
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001561:Benzilates; D005260:Female; D006801:Humans; D007045:Hysterectomy, Vaginal / Q000379:methods; D008875:Middle Aged; D009662:Nortropanes / Q000008:administration & dosage*; D010276:Parasympatholytics / Q000008:administration & dosage*; D011788:Quality of Life; D053201:Urinary Bladder, Overactive / Q000628:therapy*; D014596:Uterine Prolapse / Q000628:therapy*
chemical_list: D001561:Benzilates; D009662:Nortropanes; D010276:Parasympatholytics; C003330:trospium chloride