[Potential and usefulness of the analysis of metallic elements in blood platelets].
Platelets represent an important fraction of blood, whose composition and interactions in many physiological and pathological processes were a subject of several studies. Determination of trace elements in this component was investigated in past studies (70-80's) on small samples and by analytical techniques giving rise to not always reliable results. This study was aimed at the development of a simple method for platelet isolation and determination of trace elements by inductively coupled plasma-mass spectrometry (ICP-MS). The method was applied on blood samples from 35 healthy males with mean age of 42.5 years. The obtained results gave us the opportunity to establish a reference range of trace elements in this matrix that can be used for the interpretation of results in occupationally/environmentally exposed people or hill subjects.
Catalani
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S
Dipartimento di Medicina Sperimentale e Applicata, Sezione di Medicina del Lavoro e Igiene Industriale. Università degli Studi di Brescia.
Marini
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M
Consolandi
O
O
Gilberti
M E
ME
Apostoli
P
P
D000293:Adolescent; D001792:Blood Platelets / Q000737:chemistry*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014131:Trace Elements / Q000032:analysis*
D014131:Trace Elements