Septo-optic dysplasia and psychiatric disorders: a case report.
BACKGROUND
Septo-optic dysplasia, a variable combination of abnormalities of cerebral midline structures, is a clinically heterogeneous syndrome in which the midline defects may be implicated in psychiatric disturbances.


OBJECTIVE
To describe a case of septo-optic dysplasia associated with depression and psychosis and to discuss the role of these developmental abnormalities in psychiatric disturbances.


METHODS
The patient's clinico-anamnestic, neuroradiologic, neuropsychiatric, endocrinologic, ophthalmologic, and genetic profile was evaluated.


CONCLUSIONS
Developmental abnormalities due to disruption of the complex neural network linking the septum pellucidum with other limbic structures may have been involved in the affective and psychotic disturbances observed in our patient.
Bini
Paola
P
Department of Behavioural Neurology, UCADH, Institute of Neurology IRCCS C. Mondino, University of Pavia, Italy. paola.bini@mondino.it
Montalbetti
Lorenza
L
Tosca
Pietro
P
Ratti
Maria Teresa
MT
Uggetti
Carla
C
Moglia
Arrigo
A
Costa
Alfredo
A
D018692:Antimanic Agents / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001569:Benzodiazepines / Q000627:therapeutic use; D003866:Depressive Disorder / Q000150:complications / Q000188:drug therapy / Q000523:psychology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009483:Neuropsychological Tests; D000077152:Olanzapine; D011618:Psychotic Disorders / Q000150:complications / Q000188:drug therapy / Q000523:psychology*; D025962:Septo-Optic Dysplasia / Q000150:complications / Q000188:drug therapy / Q000523:psychology*; D014057:Tomography, X-Ray Computed; D014635:Valproic Acid / Q000627:therapeutic use; D014794:Visual Fields; D014888:Wechsler Scales
D018692:Antimanic Agents; D014150:Antipsychotic Agents; D001569:Benzodiazepines; D014635:Valproic Acid; D000077152:Olanzapine