Disturbance of cerebral neuronal migration following congenital parvovirus B19 infection.
OBJECTIVE
We describe the clinical course of an infant who presented with severe fetal anemia and fetal hydrops following congenital parvovirus B19 infection before 16 gestational weeks. The fetus was treated by cordocentesis and intrauterine transfusion at 18 weeks.


RESULTS
The infant demonstrated mild unilateral ventriculomegaly on antenatal magnetic resonance imaging, and polymicrogyria and heterotopia on postnatal magnetic resonance imaging.


CONCLUSIONS
This adds to the evidence in recent literature of central nervous system damage associated with congenital parvovirus B19 infection.
Pistorius
Lourens Rasmus
LR
Department of Obstetrics, University Medical Center Utrecht, Utrecht, The Netherlands. l.pistorius@umcutrecht.nl
Smal
Jaime
J
de Haan
Timo Robert
TR
Page-Christiaens
Godelieve C M L
GC
Verboon-Maciolek
Malgorzata
M
Oepkes
Dick
D
de Vries
Linda S
LS
D000328:Adult; D001805:Blood Transfusion, Intrauterine; D001921:Brain / Q000002:abnormalities* / Q000821:virology; D001927:Brain Diseases / Q000151:congenital / Q000473:pathology / Q000821:virology*; D002465:Cell Movement; D002828:Choristoma / Q000151:congenital / Q000473:pathology / Q000821:virology*; D018792:Encephalitis, Viral / Q000150:complications* / Q000151:congenital / Q000473:pathology; D005260:Female; D006801:Humans; D015160:Hydrops Fetalis / Q000628:therapy; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D010322:Parvoviridae Infections / Q000150:complications* / Q000151:congenital / Q000473:pathology; D016732:Parvovirus B19, Human; D011247:Pregnancy; D016216:Ultrasonography, Prenatal