Serum adiponectin concentrations correlate with severity of rheumatoid arthritis evaluated by extent of joint destruction.
Adiponectin is a hormone released by adipose tissue with antidiabetic, antiatherogenic, and anti-inflammatory properties. The present observational study focused on the relation between serum adiponectin level and the disease severity of established rheumatoid arthritis (RA). Ninety patients with more than 5-year diagnosis of RA and 42 age- and BMI-matched control were enrolled. The severity of RA was evaluated according to the number of destructed joints of overall 68 joints on plain radiographs (37 patients had mild RA and 53 had severe RA). Serum adiponectin level was significantly higher in the severe RA group (17.7+/-6.7 microg/ml) than in the control (9.1+/-3.8 microg/ml) and mild RA groups (13.9+/-6.5 microg/ml) (control vs. mild RA group, P<0.001; mild RA vs. severe RA group, P<0.01). These results suggest that increased number of joint destruction is associated with hyperadiponectinemia in established RA patients.
Ebina
Kosuke
K
Department of Orthopaedics, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
Fukuhara
Atsunori
A
Ando
Wataru
W
Hirao
Makoto
M
Koga
Tadashi
T
Oshima
Kazuya
K
Matsuda
Morihiro
M
Maeda
Kazuhisa
K
Nakamura
Tadashi
T
Ochi
Takahiro
T
Shimomura
Iichiro
I
Yoshikawa
Hideki
H
Hashimoto
Jun
J
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000503:physiopathology*; D015992:Body Mass Index; D016022:Case-Control Studies; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007249:Inflammation; D007596:Joints / Q000276:immunology / Q000503:physiopathology*; D008875:Middle Aged; D013997:Time Factors; D016896:Treatment Outcome
D052242:Adiponectin