title: Testing the validity of microwave-interfaced, in situ Raman spectroscopy as a tool for kinetic studies.
abstract: Raman spectroscopy in conjunction with microwave heating is a convenient and robust tool for monitoring organic reactions from a qualitative perspective. Its validity as a method for obtaining quantitative data is shown. Activation enthalpies for the synthesis of a range of substituted chalcones are determined and the results compared with well-established previous data and reactivity trends for this aldol condensation. The methodology is used for obtaining previously unreported pK(a) data for substituted acetophenones.
authors.affiliation: Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, Connecticut 06269-3060, USA.
authors.forename: Jason R
authors.initials: JR
authors.lastname: Schmink
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Holcomb
authors.forename: Nicholas E
authors.initials: NE
authors.lastname: Leadbeater