title: Low dosage cidofovir without probenecid as treatment for BK virus hamorrhagic cystitis after hemopoietic stem cell transplant.
abstract: We describe a single-center pediatric experience with 1 mg/kg/wk cidofovir without probenecid in 7 children with BK virus-associated hemorrhagic cystitis. Clinical improvement was observed in all cases, without adverse events, although significant reduction of urinary viral load was observed 2 weeks after the end of cidofovir in 5 out of 6 patients who completed the treatment.
authors.affiliation: Department of Haematology and Oncology, "G. Gaslini" Children Hospital, Genoa, Italy.
authors.forename: Maura
authors.initials: M
authors.lastname: Faraci
authors.forename: Daniela
authors.initials: D
authors.lastname: Cuzzubbo
authors.forename: Edoardo
authors.initials: E
authors.lastname: Lanino
authors.forename: Eddi
authors.initials: E
authors.lastname: Di Marco
authors.forename: Carmela
authors.initials: C
authors.lastname: Cirillo
authors.forename: Sandro
authors.initials: S
authors.lastname: Dallorso
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Morreale
authors.forename: Cristina
authors.initials: C
authors.lastname: Moroni
authors.forename: Elio
authors.initials: E
authors.lastname: Castagnola
mesh_terms: D000293:Adolescent; D000998:Antiviral Agents / Q000008:administration & dosage*; D001739:BK Virus / Q000302:isolation & purification*; D002648:Child; D002675:Child, Preschool; D000077404:Cidofovir; D003556:Cystitis / Q000188:drug therapy / Q000821:virology; D003596:Cytosine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004334:Drug Administration Schedule; D018380:Hematopoietic Stem Cell Transplantation; D006470:Hemorrhage / Q000188:drug therapy / Q000821:virology; D006801:Humans; D063065:Organophosphonates / Q000008:administration & dosage*; D027601:Polyomavirus Infections / Q000188:drug therapy* / Q000821:virology; D011339:Probenecid / Q000008:administration & dosage; D014412:Tumor Virus Infections / Q000188:drug therapy* / Q000821:virology
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir; D011339:Probenecid