title: Cleavage of RNA oligonucleotides by aminoglycosides.
abstract: A number of aminoglycoside antibiotics, and in particular neomycin B, are demonstrated to promote strand cleavage of RNA oligonucleotides (minimised HIV-1 TAR element and prokaryotic ribosomal A-site), by binding and causing sufficient distortion to the RNA backbone to render it more susceptible to intramolecular transesterification.
authors.affiliation: School of Chemistry, Monash University, Clayton, Vic 3800, Australia.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Belousoff
authors.forename: Bim
authors.initials: B
authors.lastname: Graham
authors.forename: Leone
authors.initials: L
authors.lastname: Spiccia
authors.forename: Yitzhak
authors.initials: Y
authors.lastname: Tor
mesh_terms: D000617:Aminoglycosides / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001483:Base Sequence; D004951:Esterification; D005601:Framycetin / Q000737:chemistry; D016325:HIV Long Terminal Repeat; D015497:HIV-1 / Q000235:genetics; D006863:Hydrogen-Ion Concentration; D007612:Kanamycin / Q000031:analogs & derivatives / Q000737:chemistry; D007700:Kinetics; D008956:Models, Chemical; D008969:Molecular Sequence Data; D009841:Oligonucleotides / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*; D012270:Ribosomes / Q000378:metabolism
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D009841:Oligonucleotides; C001495:bekanamycin; D005601:Framycetin; D007612:Kanamycin; D012313:RNA