Chest radiograph thoracic areas and lung volumes in infants developing bronchopulmonary dysplasia.
OBJECTIVE
To determine whether chest radiograph (CXR) thoracic areas and lung volumes differed between infants who did and did not develop BPD and according to the severity of BPD developed.


OBJECTIVE
Infants developing BPD, particularly if moderate or severe, would have low CXR thoracic areas and lung volumes in the perinatal period.


METHODS
Prospective study. PATIENT-SUBJECT SELECTION: 53 infants with a median gestational age of 28 (range 24-32) weeks.


METHODS
CXR thoracic areas were calculated using a Picture Archiving and Communicating System (PACS) and lung volume assessed by measurement of functional residual capacity (FRC) in the first 72 hr after birth. BPD was diagnosed if the infants were oxygen dependent beyond 28 days, mild BPD in infants no longer oxygen dependent at 36 weeks post-menstrual age (PMA) and moderate/severe BPD in infants who required supplementary oxygen with or without respiratory support at 36 weeks PMA.


RESULTS
Thirty two infants developed BPD, 21 had moderate/severe BPD. The median CXR thoracic areas were higher (P < 0.0001) and FRCs were lower (P < 0.0001) in the BPD compared to no BPD infants. The median CXR thoracic areas of the moderate/severe group (P < 0.001) and the mild group (P < 0.05) were greater than that of the no BPD group and the median FRC of the moderate/severe BPD group was lower than the no BPD group (<0.001) and the mild BPD group (P < 0.05).


CONCLUSIONS
These results highlight that in the perinatal period infants developing BPD, particularly if moderate/severe, have low functional lung volumes and may have gas trapping, which likely reflects ventilation inhomogeneity.
May
Caroline
C
MRC-Asthma Centre, Division of Asthma, Allergy and Lung Biology, King's College London, London, UK.
Prendergast
Michael
M
Salman
Saba
S
Rafferty
Gerrard F
GF
Greenough
Anne
A
D001997:Bronchopulmonary Dysplasia / Q000000981:diagnostic imaging*; D018450:Disease Progression; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008176:Lung Volume Measurements; D008297:Male; D011859:Radiography; D012720:Severity of Illness Index