Use of imaging in restorative stroke trials.
Restorative therapies aim to improve behavioral outcome after stroke by promoting repair and restoration. Measures of CNS injury and function might be useful to evaluate such therapies in a clinical trial, for example, by optimizing patient selection or treatment dose. These issues are considered in this review, with specific examples provided.
Cramer
Steven C
SC
University of California, Irvine Medical Center, 101 The City Drive South, Building 53 Room 203, Orange, CA 92868-4280, USA. scramer@uci.edu
D002986:Clinical Trials as Topic; D003952:Diagnostic Imaging / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging; D018579:Patient Selection; D049268:Positron-Emission Tomography; D020521:Stroke / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy*; D014057:Tomography, X-Ray Computed; D050781:Transcranial Magnetic Stimulation; D016896:Treatment Outcome