title: Mitochondria-targeted antioxidants in the treatment of disease.
abstract: Mitochondrial oxidative damage is thought to contribute to a wide range of human diseases; therefore, the development of approaches to decrease this damage may have therapeutic potential. Mitochondria-targeted antioxidants that selectively block mitochondrial oxidative damage and prevent some types of cell death have been developed. These compounds contain antioxidant moieties, such as ubiquinone, tocopherol, or nitroxide, that are targeted to mitochondria by covalent attachment to a lipophilic triphenylphosphonium cation. Because of the large mitochondrial membrane potential, the cations are accumulated within the mitochondria inside cells. There, the conjugated antioxidant moiety protects mitochondria from oxidative damage. Here, we outline some of the work done to date on these compounds and how they may be developed as therapies.
authors.affiliation: Department of Chemistry, University of Otago, Dunedin, New Zealand.
authors.forename: Robin A J
authors.initials: RA
authors.lastname: Smith
authors.forename: Victoria J
authors.initials: VJ
authors.lastname: Adlam
authors.forename: Frances H
authors.initials: FH
authors.lastname: Blaikie
authors.forename: Abdul-Rahman B
authors.initials: AR
authors.lastname: Manas
authors.forename: Carolyn M
authors.initials: CM
authors.lastname: Porteous
authors.forename: Andrew M
authors.initials: AM
authors.lastname: James
authors.forename: Meredith F
authors.initials: MF
authors.lastname: Ross
authors.forename: Angela
authors.initials: A
authors.lastname: Logan
authors.forename: Helena M
authors.initials: HM
authors.lastname: Cochemé
authors.forename: Jan
authors.initials: J
authors.lastname: Trnka
authors.forename: Tracy A
authors.initials: TA
authors.lastname: Prime
authors.forename: Irina
authors.initials: I
authors.lastname: Abakumova
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Jones
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Filipovska
authors.forename: Michael P
authors.initials: MP
authors.lastname: Murphy
mesh_terms: D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D018384:Oxidative Stress
chemical_list: D000975:Antioxidants