Positive and negative regulatory mechanisms in high-affinity IgE receptor-mediated mast cell activation.
Mast cells are important effector cells in allergic inflammatory reactions. The aggregation of the high-affinity IgE receptor (FcepsilonRI) on the surface of mast cells initiates a complex cascade of signaling events that ultimately leads to the release of various mediators involved in allergic inflammation and anaphylactic reactions. The release of these mediators is tightly controlled by signaling pathways that are propagated through the cell by specific phosphorylation and dephosphorylation events. These events are controlled by protein kinases and protein phosphatases which either positively or negatively regulate the propagation of the signal through the cell. This review summarizes the role of both positive and negative regulators of FcepsilonRI-induced mast cell activation.
Roth
Kristy
K
Department of Microbiology and Immunology, Dalhousie University, 5850 University Ave., Halifax, NS, Canada B3K6R8.
Chen
Wei-Min
WM
Lin
Tong-Jun
TJ
D000707:Anaphylaxis / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002460:Cell Line; D005786:Gene Expression Regulation; D006801:Humans; D006967:Hypersensitivity / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism; D020935:MAP Kinase Signaling System; D008407:Mast Cells / Q000378:metabolism*; D051379:Mice; D008954:Models, Biological; D010766:Phosphorylation; D017455:Receptors, IgE / Q000378:metabolism*; D015398:Signal Transduction
D017455:Receptors, IgE; D002118:Calcium