Economic impact of a rotavirus vaccine in Brazil.
The study was done to evaluate the cost-effectiveness of a national rotavirus vaccination programme in Brazilian children from the healthcare system perspective. A hypothetical annual birth-cohort was followed for a five-year period. Published and national administrative data were incorporated into a model to quantify the consequences of vaccination versus no vaccination. Main outcome measures included the reduction in disease burden, lives saved, and disability-adjusted life-years (DALYs) averted. A rotavirus vaccination programme in Brazil would prevent an estimated 1,804 deaths associated with gastroenteritis due to rotavirus, 91,127 hospitalizations, and 550,198 outpatient visits. Vaccination is likely to reduce 76% of the overall healthcare burden of rotavirus-associated gastroenteritis in Brazil. At a vaccine price of US$ 7-8 per dose, the cost-effectiveness ratio would be US$ 643 per DALY averted. Rotavirus vaccination can reduce the burden of gastroenteritis due to rotavirus at a reasonable cost-effectiveness ratio.
Constenla
Dagna O
DO
Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA. dagnaconstenla@yahoo.com
Linhares
Alexandre C
AC
Rheingans
Richard D
RD
Antil
Lynn R
LR
Waldman
Eliseu A
EA
da Silva
Luiz J
LJ
D001938:Brazil; D002675:Child, Preschool; D015331:Cohort Studies; D003362:Cost-Benefit Analysis / Q000706:statistics & numerical data; D005260:Female; D005759:Gastroenteritis / Q000191:economics* / Q000517:prevention & control; D006801:Humans; D007223:Infant; D008297:Male; D012401:Rotavirus / Q000187:drug effects; D012400:Rotavirus Infections / Q000191:economics* / Q000517:prevention & control; D022243:Rotavirus Vaccines / Q000191:economics*
D022243:Rotavirus Vaccines