[Influence of Cibotium barametz and its processed samples on haemorheology index in mice with adjuvant arthritis].
OBJECTIVE
To discuss the influence of the rhizome of Cibotium barametz on the heamorheology index in mice with adjuvant arthritis and to compare the effect of raw medicinals with that of the processed ones.


METHODS
Mice was injected with Freund's complete adjuvant on the rihgt behind foot to make model of adjuvant arthritis (AA). Hydroxyacrbamide tablets were orally administrated by mice with AA to make model of AA due to deficiency in the kidney (DK-AA). And then we determined the heamorheology index of the normal group, positive control group, AA group, DK-AA group and medicinals-treated groups.


RESULTS
In the groups of AA, and DK-AA, the heamorheology index, such as high shearing, middle shearing, low shearing, plasma viscosity, whole blood reduction viscosity, erythrocyte aggregation exponent, erythrocyte degeneration exponent, sedimentation, sedimentation equation K value, erythrocyte rigidity exponent, erythrocyte electrophoresis time, casson viscosity, casson yield stress, increased significantly. After treated with Cibotium barametz, the heamorheology index except red blood count, packed cell volume, fibrinogen decreased obviously to get normal.


CONCLUSIONS
Rhizome of Cibotium barametz could promote heamorheology in mice with AA and DK-AA to exhibit effect of promoting blood circulation and remove blood stasis. The medicinal rhizomes processed with sand have the effect enhanced.
Li
Jun
J
Pharmacy College, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China. sophie9cn@sina.com
Wang
Zheng-hai
ZH
Wang
Chun-tian
CT
Cao
Cui-xiang
CX
Dong
Qi-fei
QF
Jia
Tian-zhu
TZ
D000818:Animals; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D029624:Ferns / Q000737:chemistry*; D005620:Freund's Adjuvant; D018056:Hemorheology / Q000187:drug effects*; D006801:Humans; D008297:Male; D051379:Mice; D011897:Random Allocation
D004365:Drugs, Chinese Herbal; D005620:Freund's Adjuvant