Micelles and polymersomes obtained by self-assembly of dextran and polystyrene based block copolymers.
The self-assembly of dextran-block-polystyrene (dex-b-PS) block copolymers was investigated in solution. The hydrophobic PS weight fraction in these block copolymers ranges from 7 to 92% w/w, whereas the average number molar mass of dextran was kept constant at 6600 gmol(-1). Self-assembly by direct dissolution in water could be performed only for block copolymers with a low hydrophobic content (7% w/w), whereas mixtures of tetrahydrofuran and dimethylsulfoxide were required for higher PS content, before transferring the structures into water. Core-shell micelles, ovoïds, and vesicles could be identified upon characterization by light and neutrons scattering, atomic force microscopy, and transmission electron microscopy. Most of the morphologies observed were not expected considering the chemical composition of the block copolymers. Finally, the size and shape of these nanoparticles were fixed upon cross-linking the dextran block through reaction of the hydroxyl groups with divinylsulfone. The role of the dextran conformation on the self-assembly process is discussed.
Houga
Clément
C
Université de Bordeaux, Laboratoire de Chimie des Polymères Organiques UMR5629, ENSCPB-CNRS, 16 avenue Pey Berland, 33607, Pessac cedex, France.
Giermanska
Joanna
J
Lecommandoux
Sébastien
S
Borsali
Redouane
R
Taton
Daniel
D
Gnanou
Yves
Y
Le Meins
Jean-François
JF
D003911:Dextrans / Q000737:chemistry*; D004121:Dimethyl Sulfoxide / Q000737:chemistry; D005663:Furans / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D008823:Micelles; D008970:Molecular Weight; D053758:Nanoparticles / Q000737:chemistry; D010316:Particle Size; D011137:Polystyrenes / Q000737:chemistry*; D012996:Solutions; D013499:Surface Properties; D014867:Water / Q000737:chemistry
D003911:Dextrans; D005663:Furans; D008823:Micelles; D011137:Polystyrenes; D012996:Solutions; D014867:Water; C018674:tetrahydrofuran; D004121:Dimethyl Sulfoxide