Intramedullary amputation neuromas associated with spinal ependymomas.
We report 5 spinal intramedullary masses containing combined ependymoma and traumatic neuroma. The ependymomas, grade II "cellular" types, were intermixed with or separate from wavy, vaguely fascicular tissue that contained multiple axons immunoreactive for neurofilament protein. The neuromas presumably arose from small perivascular nerve twigs that have been implicated in the pathogenesis of intramedullary neuromas in non-neoplastic spinal diseases. Pathologists should be aware of this distinctive intramedullary tissue that is not to be confused with a neoplasm.
Johnson
Michael W
MW
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. mjohn125@jhmi.edu
Burger
Peter C
PC
D000293:Adolescent; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D004806:Ependymoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D009463:Neuroma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D009418:S100 Proteins / Q000032:analysis; D013116:Spinal Cord / Q000473:pathology; D013125:Spinal Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery
D014408:Biomarkers, Tumor; D005904:Glial Fibrillary Acidic Protein; D009418:S100 Proteins