title: Chenodeoxycholate is an inhibitor of Clostridium difficile spore germination.
abstract: Some cholate derivatives that are normal components of bile can act with glycine to induce the germination of Clostridium difficile spores, but at least one bile component, chenodeoxycholate, does not induce germination. Here we show that chenodeoxycholate inhibits the germination of C. difficile spores in response to cholate and taurocholate.
authors.affiliation: Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA.
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Sorg
authors.forename: Abraham L
authors.initials: AL
authors.lastname: Sonenshein
mesh_terms: D002635:Chenodeoxycholic Acid / Q000494:pharmacology*; D020355:Cholates / Q000494:pharmacology; D016360:Clostridioides difficile / Q000187:drug effects* / Q000502:physiology*; D013171:Spores, Bacterial / Q000187:drug effects / Q000502:physiology; D013656:Taurocholic Acid / Q000494:pharmacology
chemical_list: D020355:Cholates; D002635:Chenodeoxycholic Acid; D013656:Taurocholic Acid