Malariological baseline survey and in vitro antimalarial drug resistance in Gulu district, Northern Uganda.
A comprehensive, representative malaria survey has been carried out in a population of internally displaced persons (IDP) in the district of Gulu, Northern Uganda. It included 74 households and 390 persons, and covered socio-economic and environmental information, individual physical data, malaria and the drug sensitivity of Plasmodium falciparum. The prevalence of infections with Plasmodium falciparum was 54.4% at a geometric mean asexual parasitaemia of 229/microl blood, typical for hyperendemic conditions. P. falciparum turned out to be highly resistant to chloroquine and amodiaquine. It showed also reduced sensitivity against lumefantrine and artemisinin, obviously the result of the liberal use of the lumefantrine-artemether combination without evidence-based indication.
Prugger
Christof
C
Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Engl
Michael
M
Ogwang
Martin
M
Ploner
Franz
F
Ploner
Martin
M
Gluderer
Doris
D
Wernsdorfer
Gunther
G
Wernsdorfer
Walther H
WH
D000293:Adolescent; D000328:Adult; D000655:Amodiaquine / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology / Q000627:therapeutic use*; D037621:Artemisinins / Q000494:pharmacology / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000494:pharmacology / Q000627:therapeutic use; D003430:Cross-Sectional Studies; D003906:Developing Countries; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D019353:Endemic Diseases; D004983:Ethanolamines / Q000494:pharmacology / Q000627:therapeutic use; D019317:Evidence-Based Medicine; D005260:Female; D005449:Fluorenes / Q000494:pharmacology / Q000627:therapeutic use; D006306:Health Surveys; D006801:Humans; D015994:Incidence; D007223:Infant; D000078102:Lumefantrine; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000453:epidemiology*; D008297:Male; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D012036:Refugees / Q000706:statistics & numerical data*; D014454:Uganda; D055815:Young Adult
D000962:Antimalarials; D037621:Artemisinins; D004983:Ethanolamines; D005449:Fluorenes; D000655:Amodiaquine; D002738:Chloroquine; C031327:artemisinin; D000078102:Lumefantrine