title: The intimate and mysterious relationship between proton channels and NADPH oxidase.
abstract: Voltage gated proton channels and NADPH oxidase function cooperatively in phagocytes during the respiratory burst, when reactive oxygen species are produced to kill microbial invaders. Although these molecules are distinct entities, with no proven physical interaction, their presence and activity in many cells appears to be coordinated. We describe these interactions and discuss several types of mechanisms that might explain them.
authors.affiliation: Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, IL 60612, USA. Boris_Musset@rsh.net
authors.forename: Boris
authors.initials: B
authors.lastname: Musset
authors.forename: Vladimir V
authors.initials: VV
authors.lastname: Cherny
authors.forename: Deri
authors.initials: D
authors.lastname: Morgan
authors.forename: Thomas E
authors.initials: TE
authors.lastname: DeCoursey
mesh_terms: D000818:Animals; D006801:Humans; D015640:Ion Channel Gating; D007473:Ion Channels / Q000378:metabolism*; D051379:Mice; D019255:NADPH Oxidases / Q000378:metabolism*; D010586:Phagocytes / Q000378:metabolism* / Q000382:microbiology; D011522:Protons; D017382:Reactive Oxygen Species
chemical_list: D007473:Ion Channels; D011522:Protons; D017382:Reactive Oxygen Species; D019255:NADPH Oxidases