Potential oxidative stress of gold nanoparticles by induced-NO releasing in serum.
Nitric oxide (NO)-release in blood serum initiated by gold nanoparticles has been prove to be a reaction between RSNO and the gold nanoparitcles. In this reaction the NO production was catalyzed on the surface of the nanoparticles, and a new bond of Au-thiolate was simultaneously formed.
Jia
Hong Ying
HY
State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China.
Liu
Yang
Y
Zhang
Xue Ji
XJ
Han
Lu
L
Du
Li Bo
LB
Tian
Qiu
Q
Xu
Yuan Chao
YC
D015374:Biosensing Techniques; D003545:Cysteine / Q000031:analogs & derivatives / Q000097:blood; D006046:Gold / Q000494:pharmacology*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D009569:Nitric Oxide / Q000097:blood*; D009603:Nitroso Compounds / Q000097:blood; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000097:blood; D026422:S-Nitrosoglutathione / Q000097:blood; D026403:S-Nitrosothiols / Q000097:blood; D012710:Serum Albumin, Bovine
D009603:Nitroso Compounds; D017382:Reactive Oxygen Species; D026403:S-Nitrosothiols; C091665:S-nitrosoalbumin; D012710:Serum Albumin, Bovine; D009569:Nitric Oxide; D026422:S-Nitrosoglutathione; D006046:Gold; C021315:S-nitrosocysteine; D003545:Cysteine