title: [Effects of bisoprolol on serum interleukin-6 and tumor necrosis factor-alpha level in patients with congestive heart failure].
abstract: OBJECTIVE
  To investigate the levels of the serum interleukin-6(IL-6)and tumor necrosis factor-alpha (TNF-alpha) in patients with congestive heart failure (CHF) and to evaluate the beneficial effects of beta-blockers on the above variables.
  
  
  METHODS
  Studied 110 patients with CHF randomly treated with routine drugs (ACE Inhibitors, diuretics and vasodilator drugs, n=55) or additional beta-blocker bisoprolol (n=55). The levels of serum IL-6 and TNF-alpha in above patients with CHF at the different period of the course and in 50healthy humans were determined by radioimmunoassay. Simultaneously, the left ventricular ejective fraction (LVEF) of above patients were measured by nuclide ventricular imagery.
  
  
  RESULTS
  Compared with control group, the levels of serum IL-6 and TNF-alpha in patients with CHF were significantly increased during the course. There was a significantly negative correlation between IL-6, TNF-alpha and LVEF at 12 weeks after the treatment, and there were significant differences of serum IL-6 and TNF-alpha level among NYHA II, III and IV in CHF patients. The level of serum IL-6 and TNF-alpha were decreased more significantly in the bisoprolol group than in the routine group (P<0.05 ) .
  
  
  CONCLUSIONS
  Serum IL-6 and TNF-alpha level might play an important role in pathogenesis of CHF. Beta-blockers had suppress neurohumoral over activation in patients with CHF.
authors.affiliation: The Cardiovascular Department of the 2 Affiliated Hospital of Chinese PLA General Hospital, Beijing 100091, China.
authors.forename: Fa-Kuan
authors.initials: FK
authors.lastname: Tang
authors.forename: Ning
authors.initials: N
authors.lastname: Hua
authors.forename: Hong
authors.initials: H
authors.lastname: Lu
authors.forename: Jun
authors.initials: J
authors.lastname: Xiao
authors.forename: Xue-Zheng
authors.initials: XZ
authors.lastname: Tang
authors.forename: Zhi
authors.initials: Z
authors.lastname: Qi
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017298:Bisoprolol / Q000627:therapeutic use*; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha
chemical_list: D000319:Adrenergic beta-Antagonists; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D017298:Bisoprolol