title: The hypoglycaemic activity of the aqueous extract of Stachytarpheta angustifolia (Verbanaceae) in normoglycaemic and alloxan-induced diabetic rats.
abstract: The hypoglycaemic activity of the aqueous extract of Stachytarpheta angustifolia (Verbanaceae) was studied in normoglycaemic and alloxan-induced diabetic rats. The extract was administered orally to the rats and blood glucose level was monitored for 7 h. Results indicate that the aqueous extract (750 mg kg(-1)) produced a significant blood glucose reduction in both normoglycaemic and alloxan-induced diabetic rats (p < 0.05). The present result therefore appears to support the use of the plant aqueous extract for the management of type 2 diabetes by traditional medical practitioners in Northern Nigeria. The mechanism of action of the aqueous extract needs to be studied.
authors.affiliation: Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria.
authors.forename: A B
authors.initials: AB
authors.lastname: Isah
authors.forename: Y K E
authors.initials: YK
authors.lastname: Ibrahim
authors.forename: E M
authors.initials: EM
authors.lastname: Abdulrahman
authors.forename: M A
authors.initials: MA
authors.lastname: Ibrahim
mesh_terms: D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008297:Male; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D029648:Verbenaceae / Q000737:chemistry*
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D000496:Alloxan