A dissolution-diffusion model for the TAXUS drug-eluting stent with surface burst estimated from continuum percolation.
A two-layer dissolution-diffusion model is derived which incorporates a surface burst component that is estimated from continuum percolation models of overlapping Poisson distributed spheres. The model is shown to adequately describe the release properties of paclitaxel from a hydrophobic polymer matrix, including the surface burst and sustained release dependence on drug loading.
Barocas
Victor
V
Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Drasler
William
W
Girton
Tim
T
Guler
Ismail
I
Knapp
David
D
Moeller
Jeff
J
Parsonage
Edward
E
D004058:Diffusion; D016503:Drug Delivery Systems; D018625:Microscopy, Atomic Force; D008962:Models, Theoretical; D017239:Paclitaxel / Q000008:administration & dosage; D012995:Solubility; D015607:Stents; D013499:Surface Properties
D017239:Paclitaxel