Proteomic identification of tumor-associated protein in ovarian serous cystadenocarinoma.
Ovarian epithelial serous cystadenocarcinoma (OESC) is the most lethal of all gynecologic malignancies. In this report, we performed comparative proteomic study of normal ovarian epithelial and OESC tissue in order to establish OESC related protein atlas, and to identify tumor-associated proteins which may be important target proteins for clinical diagnosis and therapy and/or closely correlated to OESC pathogenesis. Six proteins were found significantly differentially expressed between normal ovarian epithelial and OESC tissues. The marked expression differences of selected proteins were further confirmed by Western blotting and immunohistochemistry. The correlation of prx-II expression with clinico-pathological features was also investigated.
Li
Xiu-Qin
XQ
China Medical University Affiliated Shengjing Hospital, Shenyang 110004, China.
Zhang
Shu-Lan
SL
Cai
Zhen
Z
Zhou
Yuan
Y
Ye
Tian-Min
TM
Chiu
Jen-Fu
JF
D014408:Biomarkers, Tumor / Q000378:metabolism; D002471:Cell Transformation, Neoplastic; D018284:Cystadenocarcinoma, Serous / Q000378:metabolism*; D015180:Electrophoresis, Gel, Two-Dimensional; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006360:Heat-Shock Proteins / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods; D009363:Neoplasm Proteins / Q000378:metabolism; D010051:Ovarian Neoplasms / Q000378:metabolism*; D010053:Ovary / Q000378:metabolism; D040901:Proteomics / Q000379:methods*; D016622:Silver Staining
D014408:Biomarkers, Tumor; D006360:Heat-Shock Proteins; D009363:Neoplasm Proteins