A preliminary study of genetic diversity of MSP-1 types in Plasmodium falciparum in southern province of Sistan Baluchistan of Iran.
Plasmodiumfalciparum merozoite surface protein-1 (MSP-1) shows extensive antigenic diversity. This is due to the presence of seven variable blocks, five semi-conserved and also five conserved blocks. The variable blocks in the MSP-1 gene are principally dimorphic, displaying either K1 or MAD20 type; except for the block 2 region which is represented by three alleles, an RO33 type in addition to the other two. Allelic diversity is reported to be generated by intra-genic recombination between the variable blocks. A study of allelic variation of MSP-1 gene in Plasmodium falciparum was carried out in the southern province of Sistan Baluchistan in Iran in 2001-2003. Samples were obtained from 30 febrile patients and DNA was extracted and association types between blocks 2 and 6 was identified on each block using specific primers and compared with those from Vietnam, Brazil and Africa. The association types obtained, were similar though less in number than the ones from Vietnam, but more than those from Africa and Brazil.
Zahra
Zamani
Z
Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran.
Reza
Razavi Mohammad
RM
Mehdi
Assmar
A
Sedigheh
Sadeghi
S
Fatemeh
Pourfallah
P
Nikoo
Nasoohi
N
Ashraf
Sheibani
S
Mohammad
Raisi
R
D000483:Alleles; D000818:Animals; D014644:Genetic Variation / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007492:Iran; D016778:Malaria, Falciparum / Q000097:blood; D020066:Merozoite Surface Protein 1 / Q000145:classification / Q000235:genetics*; D010963:Plasmodium falciparum / Q000145:classification / Q000235:genetics*
D020066:Merozoite Surface Protein 1