[Avian influenza and perspectives on vaccination against pandemic influenza].
We may expect that the next influenza pandemic will affect about half the world's population within a year and that it will cause unpredictable mortality rates. In this perspective, we review the molecular mechanisms underlying the development of new pandemic influenza strains and a discussion on existing and future vaccination strategies directed towards prevention of pandemic influenza is presented. There is an urgent need to develop paninfluenza-specific vaccines and invest substantially in new technologies in order to better meet this threat.
Holst
Peter Johannes
PJ
Institut for International Sundhed, Immunologi og Mikrobiologi, Panum Instituttet, Københavns Universitet, bygning 22.5, DK-2200 København N. p.holst@immi.ku.dk
Christensen
Jan Pravsgaard
JP
Thomsen
Allan Randrup
AR
D000818:Animals; D001717:Birds; D003140:Communicable Disease Control; D004196:Disease Outbreaks / Q000517:prevention & control; D014943:Global Health; D006801:Humans; D009980:Influenza A virus / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage*; D005585:Influenza in Birds / Q000453:epidemiology; D007251:Influenza, Human / Q000453:epidemiology / Q000401:mortality / Q000517:prevention & control
D007252:Influenza Vaccines