title: NADPH oxidases and angiotensin II receptor signaling.
abstract: Over the last decade many studies have demonstrated the importance of reactive oxygen species (ROS) production by NADPH oxidases in angiotensin II (Ang II) signaling, as well as a role for ROS in the development of different diseases in which Ang II is a central component. In this review, we summarize the mechanism of activation of NADPH oxidases by Ang II and describe the molecular targets of ROS in Ang II signaling in the vasculature, kidney and brain. We also discuss the effects of genetic manipulation of NADPH oxidase function on the physiology and pathophysiology of the renin-angiotensin system.
authors.affiliation: Division of Cardiology, Emory University, Atlanta, GA 30322, USA.
authors.forename: Abel Martin
authors.initials: AM
authors.lastname: Garrido
authors.forename: Kathy K
authors.initials: KK
authors.lastname: Griendling
mesh_terms: D001921:Brain / Q000502:physiology; D002318:Cardiovascular Diseases / Q000209:etiology / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000502:physiology; D019255:NADPH Oxidases / Q000378:metabolism*; D017382:Reactive Oxygen Species; D011945:Receptors, Angiotensin / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D017382:Reactive Oxygen Species; D011945:Receptors, Angiotensin; D019255:NADPH Oxidases