Animal models of transfusion-related acute lung injury.
Currently, more than 50 years after its apparent early recognition in case reports, and more than 20 years after its name was coined to denote a distinct entity of pulmonary transfusion reactions, transfusion-related acute lung injury (TRALI) has emerged as a serious cause of transfusion-associated morbidity and the subject of an exponentially growing scientific literature. However, review articles, clinical case reports, and case series continue to dominate the published literature on the topic and experimental studies aimed at modeling and elucidating TRALI mechanisms are less frequent. This article reviews the current status of the known experimental models of TRALI, with particular emphasis on efforts to establish in vivo animal models of this important pulmonary transfusion reaction.
Lögdberg
Lennart E
LE
Department of Pathology and Laboratory Medicine, Center for Transfusion and Cellular Therapies, Emory University School of Medicine, Atlanta, GA 30308, USA. llogdbe@emory.edu
Vikulina
Tatyana
T
Zimring
James C
JC
Hillyer
Christopher D
CD
D055371:Acute Lung Injury; D000818:Animals; D001803:Blood Transfusion; D004195:Disease Models, Animal; D006801:Humans