Antiretroviral therapy in HIV-infected patients with multidrug-resistant virus: applying the guidelines to practice.
Abstract Current treatment guidelines recommend maintenance of HIV-1 viral load below detectable levels (<50 copies per milliliter), even in extensively treated patients with multidrug-resistant HIV-1. Given recent advances in drug development and the availability of new agents with activity against antiretroviral-resistant HIV-1 viral strains, this goal is increasingly attainable for treatment-experienced patients. A stepwise approach to management of patients harboring antiretroviral-resistant HIV is presented, including assessment of adherence, a description of the use of resistance testing and utilization of new antiretroviral agents.
Kaplan
Susan S
SS
Jonathan Lax Treatment Center, Philadelphia, Pennsylvania 19107, USA. mounzerk@fight.org
Mounzer
Karam C
KC
D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000145:classification / Q000592:standards / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active / Q000592:standards*; D024921:Drug Resistance, Multiple, Viral; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D006801:Humans
D019380:Anti-HIV Agents