Pharmacokinetics of florfenicol after intravenous and intramuscular administration in New Zealand White rabbits.
The pharmacokinetic disposition and bioavailability of florfenicol (FF) were determined after single intravenous (i.v.) and intramuscular (i.m.) administrations of 25mg/kg b.w. to ten healthy New Zealand White rabbits. Plasma FF concentrations were determined by high-performance liquid chromatography (HPLC). The plasma pharmacokinetic values for FF were best described by a one-compartment open model. The elimination half-life (t(1/2beta)) was different (p<0.05) however, the area under curve (AUC) was similar (p>0.05) after i.v. and i.m. administrations. FF was rapidly eliminated (t(1/2beta) 1.49+/-0.23 h), slowly absorbed and high (F, 88.75+/-0.22%) after i.m. injection. In addition, FF was widely distributed to the body tissues (V(ss) 0.98+/-0.05 L/kg) after i.v. injection. In this study the time that plasma concentration exceeded the concentration of 2 microg/mL was approximately 6h. For bacteria with MIC of 2 microg/mL, frequent administration at this dose would be needed to maintain the concentration above the MIC. However, it is possible that rabbit pathogens may have MIC values less than 2 microg/mL which would allow for less frequent administration. Further studies are necessary to identify the range of MIC values for rabbit pathogens and to identify the most appropriate PK-PD parameter needed to predict an effective dose.
Koc
F
F
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Atatürk University, Erzurum 25400, Turkey. feridekoc@yahoo.com
Ozturk
M
M
Kadioglu
Y
Y
Dogan
E
E
Yanmaz
L E
LE
Okumus
Z
Z
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D006207:Half-Life; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D011817:Rabbits; D013839:Thiamphenicol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics
D000900:Anti-Bacterial Agents; C035534:florfenicol; D013839:Thiamphenicol