Genetic admixture and diversity estimations in the Mexican Mestizo population from Mexico City using 15 STR polymorphic markers.
The 15 AmpFlSTR Identifiler loci D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433, vWA, TPOX, D18S51, D5S818 and FGA were analyzed in a sample of 378 unrelated individuals from Mexico City, Mexico. Significant deviations from HW equilibrium in 14/15 STR loci alleles were not detected. The D18S51 locus had the highest power of discrimination (0.970). Genetic admixture estimations revealed a 69% of Amerindian, 26% of European and 5% of African contribution. Comparative analyses between Mexicans and other neighboring populations reveal significant differences in genetic diversity. Our results are important for future comparative genetic studies in different Latin American ethnic groups, particularly Mexican Mestizos and Amerindians. They should also be helpful in genetics, population evolution, forensic and paternity testing.
Juárez-Cedillo
Teresa
T
Epidemiological Research and Health Services Unit, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Zuñiga
Joaquín
J
Acuña-Alonzo
Victor
V
Pérez-Hernández
Nonanzit
N
Rodríguez-Pérez
José Manuel
JM
Barquera
Rodrigo
R
Gallardo
Guillermo J
GJ
Sánchez-Arenas
Rosalinda
R
García-Peña
Maria Del Carmen
Mdel C
Granados
Julio
J
Vargas-Alarcón
Gilberto
G
D000483:Alleles; D000704:Analysis of Variance; D044383:Black People / Q000235:genetics / Q000706:statistics & numerical data; D016172:DNA Fingerprinting / Q000379:methods; D005787:Gene Frequency; D005819:Genetic Markers; D014644:Genetic Variation; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D007198:Indians, North American / Q000235:genetics* / Q000706:statistics & numerical data; D008800:Mexico; D018895:Microsatellite Repeats / Q000235:genetics*; D011110:Polymorphism, Genetic; D011786:Quality Control; D012015:Reference Standards; D014505:Urban Population; D044465:White People / Q000235:genetics / Q000706:statistics & numerical data
D005819:Genetic Markers