Phospholipase C{beta}3 in mouse and human dorsal root ganglia and spinal cord is a possible target for treatment of neuropathic pain.
Treatment of neuropathic pain is a major clinical problem. This study shows expression of phospholipase ss3 (PLCss3) in mouse and human DRG neurons, mainly in small ones and mostly with a nonpeptidergic phenotype. After spared nerve injury, the pain threshold was strongly reduced, and systemic treatment of such animals with the unselective PLC inhibitor U73122 caused a rapid and long-lasting (48-h) increase in pain threshold. Thus, inhibition of PLC may provide a way to treat neuropathic pain.
Shi
Tie-Jun Sten
TJ
Department of Neuroscience, and Department of Clinical Science and Education, Section of Hand Surgery, Södersjukhuset, Karolinska Institutet, S 171 77 Stockholm, Sweden.
Liu
Su-Xing Leslie
SX
Hammarberg
Henrik
H
Watanabe
Masahiko
M
Xu
Zhi-Qing David
ZQ
Hökfelt
Tomas
T
D000818:Animals; D004195:Disease Models, Animal; D004963:Estrenes / Q000627:therapeutic use*; D005727:Ganglia, Spinal / Q000187:drug effects / Q000201:enzymology / Q000293:injuries; D006801:Humans; D006930:Hyperalgesia / Q000188:drug therapy* / Q000201:enzymology / Q000209:etiology; D051379:Mice; D008817:Mice, Mutant Strains; D010146:Pain / Q000188:drug therapy* / Q000201:enzymology / Q000209:etiology; D017288:Pain Threshold / Q000187:drug effects; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*; D054799:Phospholipase C beta / Q000037:antagonists & inhibitors* / Q000235:genetics; D011760:Pyrrolidinones / Q000627:therapeutic use*; D013116:Spinal Cord / Q000187:drug effects / Q000201:enzymology; D013119:Spinal Cord Injuries / Q000150:complications / Q000201:enzymology*
D004963:Estrenes; D010726:Phosphodiesterase Inhibitors; D011760:Pyrrolidinones; C060229:1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione; D054799:Phospholipase C beta