title: Effect of Shengmai injection on vascular endothelial and heart functions in patients with coronary heart disease complicated with diabetes mellitus.
abstract: OBJECTIVE
  To study the effect of Shengmai injection (, SMI) on vascular endothelial and heart functions in coronary heart disease patients complicated with diabetes mellitus (CHD-DM).
  
  
  METHODS
  One hundred and twenty patients with CHD-DM, their diagnosis confirmed by coronary arteriography, were equally randomized into a control group treated with conventional treatment and a treated group treated with conventional treatment plus SMI. The changes in blood levels of nitric oxide (NO), endothelin-1 (ET-1) and angiotensin II (Ang II), as well as endothelium-dependent vascular dilating function and heart function in the patients were observed before treatment and after the 3-week treatment.
  
  
  RESULTS
  After being treated with SMI for 3 weeks, in the treated group, blood level of NO was raised significantly from 69.8 + or - 33.1 micro mol/L to 120.1 + or - 50.8 micro mol/L, and ET-1 was lowered from 70.1 + or - 32.1 ng/L to 46.2 + or - 21.3 ng/L, respectively (P<0.01); that of Ang II was lowered from 81.3 + or - 24.3 ng/L to 50.2 + or - 27.3 ng/L (P<0.01); brachial arterial post-congestion blood flow increasing rate was raised from 389.4 + or - 26.3% to 459.3 + or - 27.8% (P<0.01); and the improvement in heart function as seen through the ejection fraction (EF) was increased from 44 + or - 5% to 68 + or - 6% (P<0.01), all the changes being more significant than those in the control group (all P<0.01).
  
  
  CONCLUSIONS
  SMI can improve not only the endothelial function in CHD-DM patients, but also heart contraction significantly.
authors.affiliation: Department of Internal Cardiology, Xinhua Hospital Affiliated to Shanghai Jiaotong University, Shanghai (200092), China.
authors.forename: Ya-chen
authors.initials: YC
authors.lastname: ZHANG
authors.forename: Bao-jing
authors.initials: BJ
authors.lastname: LU
authors.forename: Mei-hua
authors.initials: MH
authors.lastname: ZHAO
authors.forename: Ye-zhi
authors.initials: YZ
authors.lastname: RONG
authors.forename: Rui-ming
authors.initials: RM
authors.lastname: CHEN
mesh_terms: D003327:Coronary Disease / Q000188:drug therapy / Q000503:physiopathology*; D048909:Diabetes Complications / Q000503:physiopathology*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000502:physiology*; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C009252:fructus schizandrae, radix ginseng, radix ophiopogonis drug combination