title: Down-regulation of allergic responses in conditions of experimental diabetes: a role for glucocorticoids?
abstract: The prevalence of atopic diseases and diabetes is increasing worldwide, though the co-occurrence of both diseases in the same individual is less frequent than predicted. Previously published studies suggest that the Th1/Th2 concept could explain the inverse relationship between allergic diseases and type 1 diabetes. However, down-regulation of the IgE-mast cell system can also markedly contribute to the lack of responsiveness to local and systemic allergen challenges in diabetic conditions. Moreover, dysregulation of the hypothalamic-pituitary-adrenocortical axis and elevated endogenous glucocorticoid levels play a pertinent role in some of the pathological-related processes associated with poorly controlled or uncontrolled diabetes.
authors.affiliation: Laboratório de Inflamação, Departamento de Fisiologia e Farmacodinâmica, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brasil. patmar@ioc.fiocruz.br
authors.forename: Patrícia M R
authors.initials: PM
authors.lastname: e Silva
authors.forename: Vinicius F
authors.initials: VF
authors.lastname: Carvalho
authors.forename: Renato S B
authors.initials: RS
authors.lastname: Cordeiro
authors.forename: Marco A
authors.initials: MA
authors.lastname: Martins
mesh_terms: D000818:Animals; D048909:Diabetes Complications / Q000276:immunology* / Q000503:physiopathology*; D015536:Down-Regulation / Q000276:immunology; D005938:Glucocorticoids / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology* / Q000503:physiopathology*; D007108:Immune Tolerance / Q000276:immunology*; D007073:Immunoglobulin E / Q000276:immunology; D008407:Mast Cells / Q000276:immunology; D015213:Neuroimmunomodulation / Q000276:immunology; D010913:Pituitary-Adrenal System / Q000276:immunology / Q000503:physiopathology
chemical_list: D005938:Glucocorticoids; D007073:Immunoglobulin E