title: Central nervous system abnormalities in vaginismus.
abstract: OBJECTIVE
  To investigate possible altered CNS excitability in vaginismus.
  
  
  METHODS
  In 10 patients with primary idiopathic lifelong vaginismus, 10 with vulvar vestibulitis syndrome accompanied by vaginismus and healthy controls we recorded EMG activity from the levator ani (LA) and external anal sphincter (EAS) muscles and tested bulbocavernosus reflex (BCR). Pudendal-nerve somatosensory evoked potentials (SEPs) were tested after a single stimulus. Pudendal-nerve SEP recovery functions were assessed using a paired conditioning-test paradigm at interstimulus intervals (ISIs) of 5, 20 and 40ms.
  
  
  RESULTS
  EMG in patients showed muscular hyperactivity at rest and reduced inhibition during straining. The BCR polysynaptic R2 had larger amplitude (p<0.01) and longer duration (p<0.01) in patients from both groups than in controls. In controls, paired-pulse SEPs were suppressed at the 5ms ISI for N35-P40 (p<0.05) and P40-N50 ms (p<0.001) and facilitated at the 20ms ISI for N35-P40 (p<0.05) and P40-N50 (p<0.05). No significant differences were found in the paired-pulse N35-P40 in patients and controls but the cortical P40-N50 at 20 ISI was facilitated in patients (p<0.05).
  
  
  CONCLUSIONS
  EMG activity is enhanced and the cortical SEP recovery cycle and BCR are hyperexcitable in vaginismus.
  
  
  CONCLUSIONS
  The neurophysiological abnormalities in patients with vaginismus indicate concomitant CNS changes in this disorder.
authors.affiliation: Department of Neurology, ULSS15 Cittadella Hospital, Via Riva Ospedale, Cittadella, 35013 Padua, Italy. efrasson@ulss15.pd.it
authors.forename: Emma
authors.initials: E
authors.lastname: Frasson
authors.forename: Alessandra
authors.initials: A
authors.lastname: Graziottin
authors.forename: Alberto
authors.initials: A
authors.lastname: Priori
authors.forename: Elisa
authors.initials: E
authors.lastname: Dall'ora
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Didonè
authors.forename: Emilio Luigi
authors.initials: EL
authors.lastname: Garbin
authors.forename: Silvana
authors.initials: S
authors.lastname: Vicentini
authors.forename: Laura
authors.initials: L
authors.lastname: Bertolasi
mesh_terms: D000328:Adult; D001003:Anal Canal / Q000294:innervation; D016022:Case-Control Studies; D004558:Electric Stimulation; D004576:Electromyography; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D005260:Female; D006801:Humans; D018482:Muscle, Skeletal / Q000503:physiopathology; D009421:Nervous System Malformations / Q000209:etiology*; D009433:Neural Inhibition / Q000502:physiology; D017773:Pelvic Floor / Q000294:innervation; D012018:Reflex / Q000502:physiology; D013997:Time Factors; D052065:Vaginismus / Q000150:complications* / Q000473:pathology