Adult invasive pneumococcal disease pre- and peri-pneumococcal conjugate vaccine introduction in a tertiary hospital in Singapore.
Streptococcus pneumoniae isolates causing invasive disease at a large tertiary institute in Singapore from 2000 to 2007 were serotyped, with 84 (43.8 %) and 159 (82.8 %) isolates belonging to serotypes covered by the pneumococcal heptavalent conjugate and polysaccharide vaccines, respectively. All non-meningitis isolates were susceptible to penicillin, and the attributable mortality was 21.4 %. Patients who fulfilled the US Advisory Committee on Immunization Practices criteria for vaccination with the pneumococcal polysaccharide vaccine comprised 74.0 % of the study cohort and had a significantly higher mortality risk.
Hsu
Li-Yang
LY
Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Lui
See Weng
SW
School of Life Sciences & Chemical Technology, Ngee Ann Polytechnic, Singapore.
Lee
Jia Ling
JL
School of Life Sciences & Chemical Technology, Ngee Ann Polytechnic, Singapore.
Hedzlyn
Hazwany Md Mahrom
HMM
School of Life Sciences & Chemical Technology, Ngee Ann Polytechnic, Singapore.
Kong
Debra Han-Lin
DH
School of Life Sciences & Chemical Technology, Ngee Ann Polytechnic, Singapore.
Shameen
Suku
S
School of Life Sciences & Chemical Technology, Ngee Ann Polytechnic, Singapore.
Siti
Nur Puteri Mohammad
NPM
School of Life Sciences & Chemical Technology, Ngee Ann Polytechnic, Singapore.
Tan
Wei Yu
WY
School of Life Sciences & Chemical Technology, Ngee Ann Polytechnic, Singapore.
Toh
Xin Yi
XY
School of Life Sciences & Chemical Technology, Ngee Ann Polytechnic, Singapore.
Koh
Tse-Yuen
TY
School of Life Sciences & Chemical Technology, Ngee Ann Polytechnic, Singapore.
Koh
Tse-Hsien
TH
Singapore General Hospital, Singapore.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006761:Hospitals; D006801:Humans; D008297:Male; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000517:prevention & control; D022242:Pneumococcal Vaccines / Q000276:immunology*; D012846:Singapore / Q000453:epidemiology; D013296:Streptococcus pneumoniae / Q000276:immunology; D013997:Time Factors; D014611:Vaccination; D018074:Vaccines, Conjugate / Q000276:immunology*
D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate