[A case of carcinosarcoma in a patient with corrosive esophagitis].
Carcinosarcoma of the esophagus is a rare malignancy accounting for approximately 1-2% of all esophageal neoplasms. It presents as a bulky intraluminal polypoid lesion mainly in the mid to lower esophagus, which harbors both carcinomatous and sarcomatous components histologically. It often presents relatively early because of its rapid intraluminal growth. We report the case of a 69-year-old man who had suffered from dysphagia for 1 month. He was previously admitted to the hospital due to corrosive esophagitis caused by ingestion of acetic acid. Endoscopy and radiological studies revealed a bulky polypoid mass with superficial ulcerations and mucosal friability, measuring 10 cm in length approximately, in the mid-esophagus. Subtotal esophagectomy with esophagogastrostomy was done. Microscopically it was composed of sarcomatous component intermingled with squamous cell carcinoma. Immunohistochemical stains reveal cytokeratin, 34betaE12, and p63 positivity in the nests of carcinoma, and desmin and vimentin positivity in the spindle cells of sarcomatous stoma.
Oak
Ju Hyun
JH
Departments of Internal Medicine, College of Medicine, The Catholic University of Korea, St. Vincent's Hospital, Suwon, Korea.
Chung
Woo Chul
WC
Jung
Ji Han
JH
Kim
Jin Dong
JD
Lee
Jeong Rok
JR
Paik
Chang Nyol
CN
Lee
Kang Moon
KM
Cho
Kyu Do
KD
D000368:Aged; D014408:Biomarkers, Tumor / Q000276:immunology; D002296:Carcinosarcoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D004938:Esophageal Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D016629:Esophagectomy; D004941:Esophagitis / Q000139:chemically induced; D006801:Humans; D008297:Male; D014057:Tomography, X-Ray Computed
D014408:Biomarkers, Tumor