title: JBIR-23 and -24, novel anticancer agents from Streptomyces sp. AK-AB27.
abstract: The screening for active compounds against malignant pleural mesothelioma (MPM) cells produced by Streptomyces sp. AK-AB27 resulted in the isolation of two compounds with a dodecahydrodibenzo[b,d]furan skeleton named JBIR-23 (1) and -24 (2). Their structures were established on the basis of extensive NMR and MS analyses. Compounds 1 and 2 exhibited cytotoxic effects against several MPM cell lines.
authors.affiliation: Biomedicinal Information Research Center, Japan Biological Informatics Consortium, 2-42 Aomi, Koto-ku, Tokyo 135-0064, Japan.
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Motohashi
authors.forename: Ji-Hwan
authors.initials: JH
authors.lastname: Hwang
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Sekido
authors.forename: Motoki
authors.initials: M
authors.lastname: Takagi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Shin-ya
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology* / Q000627:therapeutic use; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008654:Mesothelioma / Q000188:drug therapy; D013302:Streptomyces / Q000737:chemistry* / Q000145:classification
chemical_list: D000970:Antineoplastic Agents; D001572:Benzofurans; C538842:JBIR-23; C538843:JBIR-24