title: Morphological modification of female bladder after prolonged use of soy-based diets.
abstract: OBJECTIVE
  The aim of this study was to compare the effects of a prolonged use of organic and transgenic soy upon the lipid profile and the collagen/muscle ratio of the detrusor muscle of the bladder.
  
  
  METHODS
  Wistar rats were fed three different diets from weaning until sacrifice (15 months old): control group (CG) casein-based diet; organic soy group (OSG) organic soy-based diet; genetically modified soy group (GMSG) transgenic soy-based diet.
  
  
  RESULTS
  There was no difference in the food consumption or in the diet isoflavone components among the groups. Comparing to CG, both OSG and GMSG groups presented a significant (p<0.05) reduction in the body weight, triglycerides, cholesterol and the smooth muscle of the detrusor and a significant (p<0.05) increase of collagen fibers number of the detrusor muscle.
  
  
  CONCLUSIONS
  These findings call into question that, the prolonged use of soy-based diets can be deleterious to the bladder by altering the collagen/muscle ratio what can cause bladder dysfunctions similar with that occurring during menopause.
authors.affiliation: Urogenital Research Unit-UERJ, Biomedical Center, State University of Rio de Janeiro, Av. 28 de Setembro, 87-fundos-FCM-terreo, 20551-030 Rio de Janeiro, RJ, Brazil.
authors.forename: Tatiane
authors.initials: T
authors.lastname: da Silva Faria
authors.forename: Lavínia Leal
authors.initials: LL
authors.lastname: Soares
authors.forename: Jorge L
authors.initials: JL
authors.lastname: Medeiros
authors.forename: Gilson T
authors.initials: GT
authors.lastname: Boaventura
authors.forename: Francisco J B
authors.initials: FJ
authors.lastname: Sampaio
authors.forename: Cristiane
authors.initials: C
authors.lastname: da Fonte Ramos
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood; D003094:Collagen / Q000378:metabolism*; D004032:Diet; D004958:Estradiol / Q000097:blood; D005260:Female; D030841:Food, Genetically Modified; D058870:Food, Organic; D009130:Muscle, Smooth / Q000033:anatomy & histology* / Q000378:metabolism; D051381:Rats; D045730:Soy Foods; D014280:Triglycerides / Q000097:blood; D001743:Urinary Bladder / Q000033:anatomy & histology* / Q000502:physiology
chemical_list: D014280:Triglycerides; D004958:Estradiol; D003094:Collagen; D002784:Cholesterol