title: The efficacy of thermotherapy to treat cutaneous leishmaniasis in Colombia: a comparative observational study in an operational setting.
abstract: An open label, comparative study to compare the efficacy of thermotherapy to meglumine antimoniate in treating cutaneous leishmaniasis patients in an operational context was carried out in Chaparral, Colombia. After enrollment patients were followed-up for up to 100 days. Per protocol and intention-to-treat cure rates for 47 patients treated using thermotherapy (one-time 50 degrees C applications for 30s) were 100 and 19%, respectively. Per protocol and intention-to-treat cure rates for meglumine antimoniate (20 mg/kg body weight administered intramuscularly for 21 d) were 78 and 23%, respectively.
authors.affiliation: Universidad Militar Nueva Granada, Santafé de Bogotá, Colombia.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Vega
authors.forename: Boris Fernando
authors.initials: BF
authors.lastname: Sanchez
authors.forename: Luz Mery
authors.initials: LM
authors.lastname: Montero
authors.forename: Rafael
authors.initials: R
authors.lastname: Montaña
authors.forename: Mercedes del Pilar
authors.initials: Mdel P
authors.lastname: Mahecha
authors.forename: Bladimir
authors.initials: B
authors.lastname: Dueñes
authors.forename: Angela Rocío
authors.initials: AR
authors.lastname: Baron
authors.forename: Richard
authors.initials: R
authors.lastname: Reithinger
mesh_terms: D000293:Adolescent; D000328:Adult; D000981:Antiprotozoal Agents / Q000191:economics / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003105:Colombia; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007223:Infant; D007231:Infant, Newborn; D016773:Leishmaniasis, Cutaneous / Q000175:diagnosis / Q000191:economics / Q000628:therapy*; D008297:Male; D008536:Meglumine / Q000191:economics / Q000627:therapeutic use*; D000077485:Meglumine Antimoniate; D009942:Organometallic Compounds / Q000191:economics / Q000627:therapeutic use*; D011446:Prospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000981:Antiprotozoal Agents; D009942:Organometallic Compounds; D008536:Meglumine; D000077485:Meglumine Antimoniate