title: [Expression of cyclooxygenase-2 in bladder transitional cell carcinoma and the significance thereof].
abstract: OBJECTIVE
  To study the expression of cyclooxygenase-2 (COX-2) in bladder transitional cell carcinoma (Tcc) and the clinical significance thereof.
  
  
  METHODS
  Immunohistochemistry was used to detect the expression of COX-2 in 56 specimens of bladder Tcc and 10 specimens of normal bladder tissue, all resected during operation.
  
  
  RESULTS
  No expression of COX-2 was detected in the 10 specimens of normal bladder tissue and in the 56 specimens of bladder Tcc the positive rate of COX-2 was 55.36%. The expression of COX-2 in bladder Tcc was closely correlated with the grade and stage of tumor (both P < 0.01).
  
  
  CONCLUSIONS
  COX-2 expression in bladder Tcc is closely correlated with the grade and stage.
authors.affiliation: Department of Urology, First Hospital of Harbin, Harbin 150010, China. yuleidoctor@yahoo.com.cn
authors.forename: Lei
authors.initials: L
authors.lastname: Yu
authors.forename: Xiao-jiang
authors.initials: XJ
authors.lastname: Chen
authors.forename: Pei-qing
authors.initials: PQ
authors.lastname: Shi
authors.forename: Qiang
authors.initials: Q
authors.lastname: Ding
authors.forename: Chang-hua
authors.initials: CH
authors.lastname: Sun
authors.forename: Guo-bin
authors.initials: GB
authors.lastname: Liu
authors.forename: Dong-min
authors.initials: DM
authors.lastname: Shi
authors.forename: Yong-gang
authors.initials: YG
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002295:Carcinoma, Transitional Cell / Q000378:metabolism* / Q000473:pathology; D051546:Cyclooxygenase 2 / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D001749:Urinary Bladder Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D051546:Cyclooxygenase 2