title: Evaluation of cardiac rhythm in dogs treated with levamisole hydrochloride using 24-hour ambulatory electrocardiography.
abstract: The objective of this study was to evaluate the electrocardiographic alterations in the cardiac rhythm in dogs treated with levamisole hydrochloride over a period of 24 hours. Thirty-six mixed-breed dogs, both male and female, all clinically healthy, were used in the experiment. The dogs were divided into 6 groups with 6 dogs in each group, according to dosage and route of administration. The Holter test was initiated immediately after the treatment, and was maintained for 24 hours. In the group treated with 10 mg/kg by way of subcutaneous injection, one of them showed ventricular premature complexes, sometimes isolated and other times in pairs, and ventricular tachycardia, concentrated mainly in the first hour after administration of the drug. In the group of 6 animals treated subcutaneously with 25mg/kg, four showed isolated ventricular premature complexes, ventricular bigeminy and trigeminy, mainly during the first 2 hours after administration of the drug. All the animals in the other groups showed sinus arrhythmia followed by sinus arrest. The disturbances in the cardiac rhythm observed in clinically healthy animals treated with levamisole hydrochloride, indicate that it is preferable to avoid subcutaneous administration of levamisole hydrochloride and that the oral administration of the drug should be done with caution.
authors.affiliation: Setor de Clínica de Pequenos Animais do Departamento de Medicina Veterinária, Universidade Federal de Lavras, Campus UFLA, Caixa Postal 37, CEP 37200-000, Lavras, Minas Gerais, Brazil;
authors.forename: Rodrigo B
authors.initials: RB
authors.lastname: Nogueira
authors.forename: Michiko
authors.initials: M
authors.lastname: Sakate
authors.forename: Beatriz B
authors.initials: BB
authors.lastname: Matsubara
authors.forename: Renato
authors.initials: R
authors.lastname: de Souza Gonçalves
authors.forename: Guilherme J
authors.initials: GJ
authors.lastname: Magalhães Rosa