[Role of apoptosis signal-regulating kinase 1 (ASK 1)-mediated signaling pathway during ischemic retinal injury].
Apoptosis signal-regulating kinase 1(ASK 1) is one of a growing number of mitogen-activated protein kinase (MAPK) kinase kinases identified in the c-Jun N-terminal kinase and p38 MAPK pathways. ASK 1 mediates diverse biological signals leading to cell death, differentiation, survival, and senescence, in response to cellular stress and the innate immune response. In the retina, ASK 1 is mainly expressed in retinal ganglion cells, and loss of ASK 1 leads to mild damage after ischemic injury. Consistently, ASK 1 deficient retinal ganglion cells were resistant to hydrogen peroxide. Our findings suggest that ASK 1 is involved in retinal cell death due to oxidative stress and may be a new therapeutic target for retinal degeneration.
Harada
Chikako
C
Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, 2-6 Musashidai, Fuchu-shi, Tokyo 183-8526, Japan. charada@tmin.ac.jp
D000818:Animals; D007511:Ischemia / Q000503:physiopathology*; D048848:MAP Kinase Kinase Kinase 5 / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D012160:Retina; D012164:Retinal Diseases / Q000503:physiopathology*; D012165:Retinal Ganglion Cells / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D048848:MAP Kinase Kinase Kinase 5