Surface-enhanced Raman scattering imaging of HER2 cancer markers overexpressed in single MCF7 cells using antibody conjugated hollow gold nanospheres.
Antibody-conjugated hollow gold nanospheres (HGNs) have been used for the SERS imaging of HER2 cancer markers overexpressed in single MCF7 cells. SERS mapping images show that HGNs have much better homogeneous scattering properties than silver nanoparticles. The results demonstrate the potential feasibility of HGNs as highly sensitive and homogeneous sensing probes for biological imaging of cancer markers in live cells.
Lee
Sangyeop
S
Department of Applied Chemistry, Hanyang University, Ansan 426-791, South Korea.
Chon
Hyangah
H
Lee
Moonkwon
M
Choo
Jaebum
J
Shin
Soon Young
SY
Lee
Young Han
YH
Rhyu
Im Joo
IJ
Son
Sang Wook
SW
Oh
Chil Hwan
CH
D000906:Antibodies; D014408:Biomarkers, Tumor / Q000276:immunology / Q000378:metabolism; D001943:Breast Neoplasms / Q000276:immunology / Q000378:metabolism* / Q000473:pathology*; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008853:Microscopy / Q000379:methods; D049329:Nanostructures / Q000737:chemistry / Q000648:ultrastructure; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*; D013059:Spectrum Analysis, Raman / Q000379:methods*
D000906:Antibodies; D014408:Biomarkers, Tumor; D003287:Contrast Media; D006046:Gold; D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human