[Forecast on shelf life of Chinese Angelica based on its chemical components variation].
OBJECTIVE
To predict the shelf life of Chinese Angelica by investigating the stability of its active components.


METHODS
The classic homeothermia method was used for forecast the shelf life, and HPLC was applied for quantitative determination of chemical compounds in Chinese Angelica.


RESULTS
The correlation equations, thermal constant at ambient temperature (k(25 degrees C)) and shelf life (t(0.9)) for coniferyl ferulate and Z-Ligustilide were lgk = -5152. 1/T + 13.8 (r = 0.9985), 3. 33 x 10(-4), 13 d and lgk = -4064.6/T + 10.4 (r = 0.9997), 5.91 x 10(-4), 7 d, respectively.


CONCLUSIONS
The shelf life of Chinese Angelica has been established, which suggests that it is very important for ensuring the safety and efficacy of Chinese crude drug.
Xie
Jing-jing
JJ
Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China.
Zhao
Jing
J
Li
Shao-ping
SP
D029971:Angelica sinensis / Q000737:chemistry*; D004355:Drug Stability; D004356:Drug Storage; D004365:Drugs, Chinese Herbal / Q000737:chemistry
D004365:Drugs, Chinese Herbal