[Correlations of extrocellular matrix metalloproteinase inducer and microvessel density to invasiveness of ameloblastoma].
OBJECTIVE
Matrix metalloproteinases (MMPs) are involved in local invasion of ameloblastomas. This study was to evaluate the role of matrix metalloproteinase inducer (EMMPRIN) in angiogenesis in ameloblastomas by analyzing EMMPRIN expression and microvessel density (MVD) in ameloblastomas and odontogenic cysts.


METHODS
EMMPRIN expression and MVD in 41 specimens of ameloblastoma and 40 specimens of odontogenic cyst were examined by SP immuno-histochemistry.


RESULTS
EMMPRIN was detected in all specimens of ameloblastomas and odontogenic cysts. The strong positive rate of EMMPRIN was significantly higher in ameloblastomas than in odontogenic cysts (85.4% vs. 62.5%, P<0.05). MDV was positively correlated to EMMPRIN expression to some extent (r=0.677, P<0.01).


CONCLUSIONS
EMMPRIN may play an important role during the progression of ameloblastoma via controlling angiogenesis and degradation of extracellular MMPs.
Jiang
Li-Jian
LJ
Department of Oral and Maxillofacial Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510630, P. R. China.
Shao
Chun-Kui
CK
He
Dan
D
Li
Wei-Guo
WG
Wu
Xin-Zhong
XZ
Cai
Dao-Zhang
DZ
D000328:Adult; D000564:Ameloblastoma / Q000378:metabolism* / Q000473:pathology; D051926:Basigin / Q000378:metabolism*; D005260:Female; D006801:Humans; D007573:Jaw Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D055806:Microvessels / Q000473:pathology*; D008875:Middle Aged; D009807:Odontogenic Cysts / Q000378:metabolism / Q000473:pathology; D055815:Young Adult
D051926:Basigin