title: Characterization of enterocin- and salivaricin-producing lactic acid bacteria from the mammalian gastrointestinal tract.
abstract: Bacteriocin production may be a factor contributing to bacterial dominance within complex microbial populations and may therefore be a common trait within the gut microbiota. However, of 278 antimicrobial-producing culturable lactic acid bacteria (LAB) isolated from a range of mammalian intestinal sources in this study, characterization revealed just 23 distinct strains producing bacteriocin-like inhibitory substances and one Streptococcus hyointestinalis strain producing a potentially novel protease-insensitive antimicrobial. Three class II bacteriocins previously isolated from intestinal-derived LAB were identified as enterocin A and two salivaricin P-like bacteriocins. Moreover, this is the first report of intestinal-derived Streptococcus salivarius producing variants of the lantibiotic salivaricin A.
authors.affiliation: Biotechnology Department, Teagasc, Moorepark Food Research Centre, Fermoy, Cork, Ireland.
authors.forename: Eileen F
authors.initials: EF
authors.lastname: O'Shea
authors.forename: Gillian E
authors.initials: GE
authors.lastname: Gardiner
authors.forename: Paula M
authors.initials: PM
authors.lastname: O'Connor
authors.forename: Susan
authors.initials: S
authors.lastname: Mills
authors.forename: R Paul
authors.initials: RP
authors.lastname: Ross
authors.forename: Colin
authors.initials: C
authors.lastname: Hill
mesh_terms: D000328:Adult; D000818:Animals; D001419:Bacteria / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D001430:Bacteriocins / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D002417:Cattle; D005260:Female; D041981:Gastrointestinal Tract / Q000382:microbiology*; D006801:Humans; D007231:Infant, Newborn; D019344:Lactic Acid / Q000378:metabolism*; D008297:Male; D008322:Mammals / Q000382:microbiology*; D008875:Middle Aged; D013552:Swine
chemical_list: D001426:Bacterial Proteins; D001430:Bacteriocins; C107799:enterocin A; C082674:salivaricin A; D019344:Lactic Acid