Long-term coronary endothelial function after zotarolimus-eluting stent implantation. A 9 month comparison between zotarolimus-eluting and sirolimus-eluting stents.
Implantation of a paclitaxel- or sirolimus-eluting stent (SES) may be associated with endothelial dysfunction. In the present study, we compared coronary endothelial function after zotarolimus-eluting stent (ZES) implantation to that after SES implantation. Patients who had one stent implantation for a single lesion in the left anterior descending artery were enrolled. After 6 to 9 months, coronary endothelial function was assessed in patients who showed no angiographic restenosis. Endothelium-dependent vasomotion was determined after intracoronary infusion of acetylcholine. Also, endothelium-independent vasomotion was assessed after nitrate infusion. A total of 23 patients (11 in the ZES group, 12 in the SES group) were included. In distal and far distal segments, the SES group showed significant vasoconstriction by acetylcholine. However, no significant vasomotion was observed in the ZES group (SES versus ZES: -36.1% versus -3.3% for distal; P = 0.003, -34.7% versus -3.4% for far distal; P = 0.003). Endothelium-independent vasodilatation by nitrates was preserved in all subjects. SES implantation may induce significant impairment of the endothelium-dependent vasomotor function in the distal portion of the treated vessel, while ZES implantation may not. Our results suggest that the change in coronary endothelial function after stent implantation could be different according to the type of DES.
Shin
Dong Il
DI
Department of Internal Medicine, Kangnam St. Mary's Hospital, The Catholic University of Korea, South Korea.
Seung
Ki-Bae
KB
Kim
Pum Joon
PJ
Chang
Kiyuk
K
Choi
Jae Kee
JK
Jeon
Doo Soo
DS
Kim
Mi-Jeong
MJ
Lee
Man Young
MY
Chung
Wook Sung
WS
D003331:Coronary Vessels / Q000187:drug effects / Q000502:physiology*; D054855:Drug-Eluting Stents; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020123:Sirolimus / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000494:pharmacology; D014666:Vasomotor System / Q000187:drug effects
C489443:zotarolimus; D020123:Sirolimus