Human chorionic gonadotrophin producing epithelioid sarcoma metastatic to the placenta.
Pregnancy complicated by sarcoma is a rare event, and metastasis to the placenta is exceptionally rare. Of reported malignancies involving the products of conception, only 8% are sarcomas. We report the first case of placental metastasis of an epithelioid sarcoma, an uncommon malignancy which most frequently affects young adults. In addition to the typical histological features and immunophenotypic profile expected of epithelioid sarcoma, this tumor also expressed human chorionic gonadotrophin (HCG). Although uncharacteristic, the production of HCG has been previously reported in other nontrophoblastic tumors. It may have contributed to the pathogenesis of the tumor metastatic to the placenta in this case.
Steffensen
Thora S
TS
Department of Pathology, University of South Florida and Tampa General Hospital, Tampa, Florida 33606, USA.
Gilbert-Barness
Enid
E
Wagoner
Michael J
MJ
Bui
Marilyn M
MM
Browarsky
Irwin L
IL
D000328:Adult; D006063:Chorionic Gonadotropin / Q000378:metabolism*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D010920:Placenta / Q000473:pathology*; D010922:Placenta Diseases / Q000378:metabolism / Q000473:pathology*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000378:metabolism / Q000473:pathology*; D012509:Sarcoma / Q000378:metabolism / Q000473:pathology / Q000556:secondary*; D055815:Young Adult
D006063:Chorionic Gonadotropin