title: Prognostic factors of patients with ovarian yolk sac tumors: a study in Chinese patients.
abstract: BACKGROUND
  The aim of this study was to investigate the prognostic factors of ovarian yolk sac tumors (YST) and the survival rates in Chinese patients.
  
  
  METHODS
  We retrospectively reviewed 76 patients with ovarian YST from the Department of Obstetrics and Gynecology, Liaoning Cancer Hospital & Institute, China, between 1984 and 2007.
  
  
  RESULTS
  Five-year overall survival rates in stages I, II, III, and IV were 91.8, 88.9, 39.5, and 25.0%, respectively. Age, histologic type, preoperative serum alpha-fetoprotein level, fertility-sparing surgery, tumor size and lymphadenectomy did not affect the prognosis of YST in our study. Multivariate analysis confirmed cisplatin-based chemotherapy (hazard ratio (HR) = 4.945), chemotherapy courses > 3 (HR = 2.954), residual tumor < or = 2 cm (HR = 0.224) and ascites volume < or = 100 ml (HR = 0.389) as independent predictors for overall survival.
  
  
  CONCLUSIONS
  Our study demonstrated that the 5-year overall survival rate of YST was 53.9% for the Liaoning Cancer Hospital & Institute, China. Cisplatin-based chemotherapy, chemotherapy courses, residual tumor size and ascites volume were independent prognosis factors.
authors.affiliation: Department of Obstetrics and Gynecology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Tong
authors.forename: Qi
authors.initials: Q
authors.lastname: You
authors.forename: Liankun
authors.initials: L
authors.lastname: Li
authors.forename: Liying
authors.initials: L
authors.lastname: Cai
authors.forename: Chunyan
authors.initials: C
authors.lastname: Wang
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zheng
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D018240:Endodermal Sinus Tumor / Q000401:mortality* / Q000628:therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000517:prevention & control*; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000401:mortality*; D015995:Prevalence; D011379:Prognosis; D016016:Proportional Hazards Models; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D016896:Treatment Outcome; D055815:Young Adult