title: Serum anti-myelin-associated glycoprotein antibodies in Egyptian autistic children.
abstract: Autoimmunity to brain could play an etiopathogenic role in a subgroup of autistic patients. The frequency of serum anti-myelin-associated glycoprotein antibodies, as an index for autoimmunity to brain, and their relation to family history of autoimmunity were investigated in 32 autistic and 32 healthy matched children. Autistic children had significantly higher serum anti-myelin-associated glycoprotein antibodies than healthy children (2100 [1995] and 1138 [87.5] Buhlmann titre unit, P < .001). Anti-myelin-associated glycoprotein positivity was elicited in 62.5% of autistic children. Family history of autoimmunity in autistic children (50%) was significantly higher than controls (9.4%). Anti-myelin-associated glycoprotein serum levels were significantly higher in autistic children with than those without such history (P < .05). In conclusion, autism could be, in part, one of the pediatric autoimmune neuropsychiatric disorders. Further studies are warranted to shed light on the etiopathogenic role of anti-myelin-associated glycoprotein antibodies and the role of immunotherapy in autism.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt. hafezg@softhome.net
authors.forename: Gehan Ahmed
authors.initials: GA
authors.lastname: Mostafa
authors.forename: Zeinab Awad
authors.initials: ZA
authors.lastname: El-Sayed
authors.forename: Manal Mohamed Abd
authors.initials: MM
authors.lastname: El-Aziz
authors.forename: Mohamed Farouk
authors.initials: MF
authors.lastname: El-Sayed
mesh_terms: D000906:Antibodies / Q000097:blood*; D001321:Autistic Disorder / Q000097:blood* / Q000276:immunology* / Q000473:pathology; D001921:Brain / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D004534:Egypt / Q000453:epidemiology; D004569:Electroencephalography / Q000379:methods; D005260:Female; D006801:Humans; D007360:Intelligence; D008297:Male; D018992:Myelin-Associated Glycoprotein / Q000276:immunology*; D012189:Retrospective Studies; D012892:Sleep Deprivation / Q000503:physiopathology; D018709:Statistics, Nonparametric
chemical_list: D000906:Antibodies; D018992:Myelin-Associated Glycoprotein