SURA2 targeting for cardioprotection?
SUR2A is an ATP-binding protein known to serve as a regulatory subunit of metabolic-sensing, cardioprotective sarcolemmal ATP-sensitive K(+) (K(ATP)) channels. It has been recently found that a moderate increase in expression of SUR2A protects the heart against different types of metabolic stresses, including ischaemia/reperfusion and hypoxia. Although the sarcolemmal K(ATP) channel is a multiprotein complex composed of many proteins in vivo, it seems that an increase in SUR2A levels is sufficient to increase the number of sarcolemmal K(ATP) channels. This effect of SUR2A could be due to SUR2A being the rate-limiting factor in generating fully composed sarcolemmal K(ATP) channels. An increased number of sarcolemmal K(ATP) channels seems to protect the heart by regulating action membrane potential, inhibiting Ca(2+) influx and preventing Ca(2+) overload, although an additional yet to be recognised mechanism independent of K(ATP) channels activity cannot be excluded.
Jovanović
Aleksandar
A
Division of Medical Sciences, Ninewells Hospital & Medical School, University of Dundee, Dundee DD1 9SY, UK. a.jovanovic@dundee.ac.uk
Jovanović
Sofija
S
D018528:ATP-Binding Cassette Transporters / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D016503:Drug Delivery Systems; D006801:Humans; D000860:Hypoxia / Q000188:drug therapy / Q000503:physiopathology*; D054086:KATP Channels / Q000378:metabolism; D024661:Potassium Channels, Inwardly Rectifying / Q000378:metabolism / Q000502:physiology*; D011955:Receptors, Drug / Q000378:metabolism / Q000502:physiology*; D015427:Reperfusion Injury / Q000188:drug therapy / Q000378:metabolism*; D012508:Sarcolemma / Q000378:metabolism; D064233:Sulfonylurea Receptors
C577510:ABCC9 protein, human; D018528:ATP-Binding Cassette Transporters; D002316:Cardiotonic Agents; D054086:KATP Channels; D024661:Potassium Channels, Inwardly Rectifying; D011955:Receptors, Drug; D064233:Sulfonylurea Receptors