title: Advanced nanotechnological approaches for designing protein-based "lab-on-chips" sensors on porous silicon wafer.
abstract: In this article, we will review the more recent patented approaches related to the design and development of micro- and nano-patterns of biomolecules on solid substrates for the realization of innovative biochips, including inkjet and spotting technology, and Scanning Probe Methods In addition, we will report on some important patents based on the use of porous materials as substrates, exploiting the large specific surface for the design of highly sensitive biodevices. The main advantages and drawbacks related to each technological approach to the biochips fabrication will be pointed out, and future perspectives in the field will be discussed.
authors.affiliation: Istituto Nazionale di Ricerca Metrologica, Strada delle Cacce, 91 Torino 10135, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Borini
authors.forename: Maria
authors.initials: M
authors.lastname: Staiano
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Rocchia
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Rossi
authors.forename: Mose
authors.initials: M
authors.lastname: Rossi
authors.forename: Sabato
authors.initials: S
authors.lastname: D'Auria
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D056656:Lab-On-A-Chip Devices; D018625:Microscopy, Atomic Force / Q000295:instrumentation; D036103:Nanotechnology / Q000295:instrumentation*; D010330:Patents as Topic; D016062:Porosity; D011506:Proteins / Q000737:chemistry; D012825:Silicon / Q000737:chemistry*
chemical_list: D011506:Proteins; D012825:Silicon