Switchable electrostatic interactions between gold nanoparticles and coiled coil peptides direct colloid assembly.
The nanoparticle-peptide interaction described here is based on electrostatic forces and the pH value can act as a trigger to direct the organization of functionalized nanoparticles in a reversible and repeatable manner. The ability of the peptide to interact with the charged gold nanoparticles is directly related to its helical structure and was not found for a random coil peptide with the same net charge. Interestingly, the interaction with nanoparticles seems to induce a fibrillation of the coiled coil peptide.
Wagner
Sara C
SC
Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustrasse 3, 14195 Berlin, Germany.
Roskamp
Meike
M
Cölfen
Helmut
H
Böttcher
Christoph
C
Schlecht
Sabine
S
Koksch
Beate
B
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D003102:Colloids / Q000737:chemistry*; D020285:Cryoelectron Microscopy / Q000379:methods; D006046:Gold / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D053768:Metal Nanoparticles / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission / Q000379:methods; D008969:Molecular Sequence Data; D008970:Molecular Weight; D036103:Nanotechnology / Q000379:methods; D010455:Peptides / Q000737:chemistry*; D017433:Protein Structure, Secondary; D012666:Semiconductors; D055672:Static Electricity
D003102:Colloids; D010455:Peptides; D006046:Gold