3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymerase.
Isoquinoline-based non-nucleoside inhibitors of HCV NS5b RNA-dependent RNA-polymerase are described. The synthesis and structure-activity relationships are detailed, along with enzyme and cellular activity.
Hendricks
Robert T
RT
Roche Palo Alto LLC, Medicinal Chemistry, 3431 Hillview Avenue, MS: R6E-3 (R6W-120B), Palo Alto, CA 94304, USA. Than.Hendricks@Roche.com
Spencer
Stacey R
SR
Blake
James F
JF
Fell
Jay B
JB
Fischer
John P
JP
Stengel
Peter J
PJ
Leveque
Vincent J P
VJ
Lepogam
Sophie
S
Rajyaguru
Sonal
S
Najera
Isabel
I
Josey
John A
JA
Swallow
Steven
S
D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D007546:Isoquinolines / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D012324:RNA-Dependent RNA Polymerase / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D007546:Isoquinolines; D017361:Viral Nonstructural Proteins; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase