title: Serum levels of MIP-1beta and RANTES in HIV-1 subtype CRF01_AE infected patients with different rates of disease progression.
abstract: The beta-chemokines have been shown to inhibit HIV replication in vitro. To evaluate the role of serum beta-chemokines in disease progression and their anti-viral role in vivo, we determined serum levels of macrophage inflammatory protein-1beta (MIP-1beta) and regulated upon activation normal T-cell expressed and secreted (RANTES) of twenty HIV-1 subtype CRF01_AE infected patients: nine progressors (PRs, follow-up CD4+ cell count < 200/mm3 and progression to AIDS or death) and eleven slower progressors (SPs, asymptomatic and/or follow-up CD4+ cell counts > 350/mm3 at the end of follow-up) and determined their plasma viral loads. The subjects were followed for at least 36 months. All had initial CD4 values > 350 cells/mm3. In this longitudinal study, serum levels of MIP-1beta and RANTES in specimens obtained either early or later in the course of HIV infection did not differ significantly between progressors and slower progressors (p > 0.05). There were no significant changes in serum MIP-1beta and RANTES levels over time in either patient group (p > 0.05). No significant associations were observed between plasma viral loads and the measured beta-chemokines (r = -0.205, p = 0.21 for MIP-1beta and r = -0.12, p = 0.492 for RANTES). The results suggest these chemokines do not play a major systemic role in control of viremia or protection against the progression of HIV disease.
authors.affiliation: Armed Forces Research Institute of Medical Sciences (AFRIMS), Bangkok, Thailand. ThippawanC@afrims.org
authors.forename: Thippawan
authors.initials: T
authors.lastname: Chuenchitra
authors.forename: Chantapong
authors.initials: C
authors.lastname: Wasi
authors.forename: Mark
authors.initials: M
authors.lastname: de Souza
authors.forename: Sorachai
authors.initials: S
authors.lastname: Nitayaphan
authors.forename: Suda
authors.initials: S
authors.lastname: Louisirirotchanakul
authors.forename: Ruengpung
authors.initials: R
authors.lastname: Sutthent
authors.forename: Arthur E
authors.initials: AE
authors.lastname: Brown
authors.forename: Deborah L
authors.initials: DL
authors.lastname: Birx
authors.forename: Victoria R
authors.initials: VR
authors.lastname: Polonis
mesh_terms: D018791:CD4 Lymphocyte Count; D054407:Chemokine CCL4 / Q000097:blood*; D018946:Chemokine CCL5 / Q000097:blood*; D018450:Disease Progression; D015658:HIV Infections / Q000097:blood* / Q000503:physiopathology; D015497:HIV-1; D006801:Humans; D012367:RNA, Viral / Q000097:blood; D019562:Viral Load
chemical_list: C066507:CCL4 protein, human; D054407:Chemokine CCL4; D018946:Chemokine CCL5; D012367:RNA, Viral