Some immunomodulatory effects of probiotic bacteria might be due to porcine neutrophil elastase inhibitor, a serpin present in MRS broth.
Use of conditioned media (CM) is a common practice for the study of the immunomodulatory effects of probiotic bacteria on the human host. Serpins and other immunomodulatory proteins/peptides that are present in CM may be responsible for some of the observed effects, which in fact might have been attributed to probiotic bacteria. The exact effects of serpin have thus to be assessed.
Urdaci
María C
MC
Sánchez
Borja
B
D000332:Aerobiosis / Q000276:immunology; D000693:Anaerobiosis / Q000276:immunology; D000818:Animals; D017077:Culture Media, Conditioned / Q000737:chemistry / Q000494:pharmacology*; D007155:Immunologic Factors / Q000276:immunology / Q000378:metabolism*; D019936:Probiotics / Q000378:metabolism*; D053491:Proteinase Inhibitory Proteins, Secretory / Q000378:metabolism*; D015843:Serpins / Q000276:immunology / Q000494:pharmacology*; D013552:Swine; D053719:Tandem Mass Spectrometry
D017077:Culture Media, Conditioned; D007155:Immunologic Factors; D053491:Proteinase Inhibitory Proteins, Secretory; D015843:Serpins