title: Physiopathology and management of osteonecrosis of the jaws related to bisphosphonate therapy for malignant bone lesions. A French expert panel analysis.
abstract: Bisphosphonates (BP) are the current standard of care for preventing malignant skeletal related-events. Recent reports have documented the relationship between osteonecrosis of the jaws (ONJ) and the use of BPs. Based on the opinion of experts, the purpose of our analysis was to summarize current knowledge, to propose therapeutic options, and to define areas of research. Identified risk factors were long-lasting exposure to BPs, intravenous nitrogen-containing BPs, and poor dental status. Three major hypotheses could explain the genesis of ONJ: excess of bone turnover inhibition, antiangiogenic effect, and local infection. Before the onset of therapy, the dental status must be controlled, and followed during treatment. Dental procedures could worsen the risk of ONJ, and indications must be well evaluated. When an ONJ occurs, the management should be adapted according to its extent. Thereby, a customization of BP therapy should be applied taking into account the aggressiveness of the underlying disease.
authors.affiliation: Department of Medical Oncology, Centre René Huguenin, 35 rue Daily, 92210 Saint-Cloud, France. m.tubiana@stcloud-huguenin.org
authors.forename: Michèle
authors.initials: M
authors.lastname: Tubiana-Hulin
authors.forename: Marc
authors.initials: M
authors.lastname: Spielmann
authors.forename: Christian
authors.initials: C
authors.lastname: Roux
authors.forename: Mario
authors.initials: M
authors.lastname: Campone
authors.forename: Laurent
authors.initials: L
authors.lastname: Zelek
authors.forename: Joseph
authors.initials: J
authors.lastname: Gligorov
authors.forename: Jacky
authors.initials: J
authors.lastname: Samson
authors.forename: Philippe
authors.initials: P
authors.lastname: Lesclous
authors.forename: Jean-Denis
authors.initials: JD
authors.lastname: Laredo
authors.forename: Moïse
authors.initials: M
authors.lastname: Namer
mesh_terms: D001859:Bone Neoplasms / Q000188:drug therapy*; D004164:Diphosphonates / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D015994:Incidence; D007571:Jaw Diseases / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D010020:Osteonecrosis / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*
chemical_list: D004164:Diphosphonates