Practical method for asymmetric addition of arylboronic acids to alpha,beta-unsaturated carbonyl compounds utilizing an in situ prepared rhodium catalyst.
A new practical method for the asymmetric Michael addition of arylboronic acids to alpha,beta-unsaturated carbonyl compounds utilizing in situ generated chiral rhodium-binap-based catalyst has been developed to address the unavailability of the preformed catalysts. While maintaining high levels of enantioselectivity reported for the preformed catalysts, the new method provides a convenient access to either enantiomeric form of the product and allows for a substantial reductions in both the boronic acid and the catalyst loads.
Lukin
Kirill
K
GPRD Process Research and Development, Abbott Laboratories, North Chicago, Illinois 60064, USA. kirill.lukin@abbott.com
Zhang
Qunying
Q
Leanna
M Robert
MR
D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*
D001897:Boronic Acids; D007659:Ketones; D012238:Rhodium