Inhibition of carrageenan-induced edema by tripleurospermum disciforme extract in rats.
In this research anti-inflammatory effect of Tripleurospermum disciforme extract was studied in rats. The effect of the extract against acute inflammation was studied by hind paw edema test. Intraperitoneal injection of different doses (15, 30, 45, 60, 90 and 120 mg kg(-1)) of Tripleurospermum disciforme which was followed by hind paw carageenan injection 1 h later were investigated. The resultant edema was quantified by measuring changes of diameter of hind foot. After 2, 3, 4 and 6 h we measured the anti-inflammatory effect of Tripleurospermum disciforme extract. Tripleurospermum disciforme extract with doses of 45, 60, 90 and 120 mg kg(-1) and indomethacin 5 mg kg(-1) showed significant effect. It is concluded that Tripleurospermum disciforme extract has anti-inflammatory effect against acute inflammation.
Bakhtiarian
Azam
A
Department of Pharmacology, Medical Sciences, University of Tehran, Tehran, Iran.
Ejtemaimehr
Shahram
S
Strobl
Sylvia
S
Pournaghash-Tehrani
Said
S
Partoazar
Alireza
A
Ghamami
Guiti
G
Yasa
Narges
N
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D002351:Carrageenan / Q000037:antagonists & inhibitors* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D007213:Indomethacin / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D031169:Tripleurospermum / Q000737:chemistry*
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D002351:Carrageenan; D007213:Indomethacin