A comparative study on the efficacy of treatment with 585 nm pulsed dye laser and ultraviolet B-TL01 in plaque type psoriasis.
BACKGROUND
Narrow-band ultraviolet-B and pulsed dye laser (PDL) affect psoriasis but via different pathways.


OBJECTIVE
To compare the results of PDL with ultraviolet-B light therapy (UVB) and to look for synergism of both therapies in patients with plaque type psoriasis.


METHODS
In each eligible individual, four similar target plaques were selected, and halves of these plaques were treated using PDL, UVB, or a combination of PDL and UVB or were not treated. Results were recorded single-blind using the Physician's Global Assessment score at study enrolment and Week 13. Nonparametric, paired statistical tests were used to test for differences within and between therapies.The results were also analyzed after dichotomization of the changes in the Physician's Global Assessment score into responsive and nonresponsive to treatment.


RESULTS
A significant improvement of the psoriasis lesions was noted at Week 13 (P<.001) with each therapy. No significant differences were noted between the therapies. Synergism of PDL and UVB was not observed.


CONCLUSIONS
PDL is safe for treating plaque type psoriasis, but its efficacy is limited to a subgroup of patients. Combining PDL with UVB has no additional benefit.
De Leeuw
Jaap
J
Department of Dermatology and Venereology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. j.deleeuw@erasmusmc.nl
Van Lingen
Rosanne G
RG
Both
Hilde
H
Tank
Bhupendra
B
Nijsten
Tamar
T
Martino Neumann
H A
HA
D000328:Adult; D005260:Female; D006801:Humans; D054025:Lasers, Dye / Q000009:adverse effects / Q000627:therapeutic use*; D028022:Low-Level Light Therapy / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011565:Psoriasis / Q000532:radiotherapy / Q000628:therapy*; D014467:Ultraviolet Therapy / Q000009:adverse effects