Characterizations of the TiO(2-x) films synthesized by e-beam evaporation for endovascular applications.
Different chemical states of titanium oxide films were deposited on commercially pure Ti (CP Ti) by electron-beam evaporation at different oxygen flow rates to examine a possibility of their applications to endovascular stents. The surface morphology, chemical composition and crystal structure of the obtained titanium oxide films were analyzed by FE-SEM, XPS and XRD, respectively. As a function of the deposition parameters employed, the obtained titanium oxide films demonstrated different mixtures of anatase phase, Ti2O3 and TiO. By the formation of titanium oxide film on the CP Ti plate, the contact angle was decreased and the cellular activity of porcine aortic smooth muscle cells was increased. Post-deposition annealing was also found to be an important factor to achieve advantageous biocompatibility. When haemocompatibility was investigated by observing adhesion of blood platelets from platelet-rich plasma, less platelet adhesion was observed on titanium oxide films. These results indicated that titanium oxide film synthesized by e-beam evaporation could be applicable to coronary stents.
Lin
Zeng
Z
Vacuum and Fluid Engineering Research Center, Northeastern University, Shenyang 110004, People's Republic of China.
Lee
In-Seop
IS
Choi
Yoon-Jeong
YJ
Noh
In-Sup
IS
Chung
Sung-Min
SM
D001672:Biocompatible Materials / Q000737:chemistry*; D001792:Blood Platelets / Q000166:cytology / Q000502:physiology*; D001807:Blood Vessel Prosthesis; D002478:Cells, Cultured; D003460:Crystallization / Q000379:methods*; D004583:Electrons; D008422:Materials Testing; D008567:Membranes, Artificial; D010316:Particle Size; D010973:Platelet Adhesiveness / Q000502:physiology; D011474:Prosthesis Design; D015607:Stents; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry* / Q000528:radiation effects
D001672:Biocompatible Materials; D008567:Membranes, Artificial; C009495:titanium dioxide; D014025:Titanium