[Use of modification of diet in renal disease equation in estimating renal insufficiency in type 2 diabetes patients].
OBJECTIVE
To investigate the significance of use of modification of diet in renal disease (MDRD) equation in calculating glomerular filtration rate (GFR) so as to estimate the prevalence of "renal insufficiency" in type 2 diabetes patients.


METHODS
Serum creatinine (Scr) and 24h-urinary albumin excretion (24 h-UAE) were measured in 1576 hospitalized type 2 diabetes patients. MDRD equation was used to calculate the GFR (GFR(MDRD)). GFR(MDRD) < 60 ml/min per 1.73 m2 was defined as "renal insufficiency".


RESULTS
(1) Of the 1576 subjects, 908 (57.6%), 503 (31.9%), and 165 (10.5%) had GFR(MDRD) > or =90, 90-60, and <60 ml/min per 1.73 m2 respectively. The prevalence of "renal insufficiency" was increased with aging (P < 0.01). (2) The prevalence rates of "renal insufficiency" of the normo-, micro-, and macroalbuminuric groups were 4.8%, 14.4%, and 43.4% respectively, with significant differences among them (all P < 0.01). (3) Of the 165 subjects with "renal insufficiency", 21 (12.7%) had neither abnormal Scr nor abnormal albuminuria.


CONCLUSIONS
Able to discover renal insufficiency early, MDRD equation has important clinical significance in evaluating the progression of renal dysfunction in type 2 diabetes patients.
Li
Qing
Q
Department of Endocrinology and Metabolism, Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China.
Yang
Ming
M
Bao
Ya-qian
YQ
Yu
Hao-yong
HY
Li
Ming
M
Zhou
Jian
J
Jia
Wei-Ping
WP
Xiang
Kun-san
KS
D000368:Aged; D000419:Albuminuria / Q000652:urine; D000465:Algorithms; D002681:China / Q000453:epidemiology; D003404:Creatinine / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003928:Diabetic Nephropathies / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007297:Inpatients / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D051437:Renal Insufficiency / Q000453:epidemiology* / Q000209:etiology
D003404:Creatinine