title: Proton magnetic resonance spectroscopy in multiple sclerosis.
abstract: Proton magnetic resonance spectroscopy ((1)H-MRS) provides tissue metabolic information in vivo. This article reviews the role of MRS-determined metabolic alterations in lesions, normal-appearing white matter, gray matter, and spinal cord in advancing our knowledge of pathologic changes in multiple sclerosis (MS). In addition, the role of MRS in objectively evaluating therapeutic efficacy is reviewed. This potential metabolic information makes MRS a unique tool to follow MS disease evolution, understand its pathogenesis, evaluate the disease severity, establish a prognosis, and objectively evaluate the efficacy of therapeutic interventions.
authors.affiliation: Department of Radiology, University of Nebraska Medical Center, 981045 Nebraska Medical Center, Omaha, NE 68198-1045, USA.
authors.forename: Balasrinivasa R
authors.initials: BR
authors.lastname: Sajja
authors.forename: Jerry S
authors.initials: JS
authors.lastname: Wolinsky
authors.forename: Ponnada A
authors.initials: PA
authors.lastname: Narayana
mesh_terms: D001921:Brain / Q000378:metabolism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000378:metabolism*