Intraductal carcinoma arising in intraductal papilloma in an axillary lymph node: review of the literature and proposed theories of evolution.
We report a case of an axillary lymph node containing benign glandular lesions, intraductal papilloma with florid and atypical duct hyperplasia, and ductal carcinoma in situ. We propose 2 theories for the development of the intraductal papilloma: from adjacent benign glandular inclusions, or from displaced epithelial cells from a previous intraductal papilloma in the ipsilateral breast. This case identifies yet another etiology for false-positive sentinel lymph nodes morphologically and by immunohistochemistry.
Jaffer
Shabnam
S
Department of Pathology, The Mount Sinai Medical Center, NewYork, NY 10029, USA. shabnam.jaffer@msnyuhealth.org
Lin
Robert
R
Bleiweiss
Ira J
IJ
Nagi
Chandandeep
C
D001365:Axilla / Q000473:pathology; D001706:Biopsy; D001943:Breast Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008875:Middle Aged; D018300:Papilloma, Intraductal / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology