title: Catalytic asymmetric hydrogenation of alpha-amino-beta-keto ester hydrochlorides using homogeneous chiral nickel-bisphosphine complexes through DKR.
abstract: Homogeneous chiral nickel-bisphosphine complexes catalyze the asymmetric hydrogenation of alpha-amino-beta-keto ester hydrochlorides through dynamic kinetic resolution to efficiently afford anti-beta-hydroxy-alpha-amino esters with high diastereo- and enantioselectivities.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho, Inage-ku, Chiba, 263-8522, Japan. hamada@p.chiba-u.ac.jp
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Hamada
authors.forename: Yu
authors.initials: Y
authors.lastname: Koseki
authors.forename: Takefumi
authors.initials: T
authors.lastname: Fujii
authors.forename: Tsukuru
authors.initials: T
authors.lastname: Maeda
authors.forename: Takuya
authors.initials: T
authors.lastname: Hibino
authors.forename: Kazuishi
authors.initials: K
authors.lastname: Makino
mesh_terms: D000588:Amines / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry; D002384:Catalysis; D004951:Esterification; D006851:Hydrochloric Acid / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*; D007700:Kinetics; D008024:Ligands; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*; D012997:Solvents; D013237:Stereoisomerism
chemical_list: D000588:Amines; D000596:Amino Acids; D008024:Ligands; D010720:Phosphines; D012997:Solvents; D009532:Nickel; D006859:Hydrogen; C044646:phosphine; D006851:Hydrochloric Acid