Positive c-ANCA in a Patient with Lymphoma and Without Vasculitis.
Wegener's granulomatosis is an uncommon systemic disease characterized by necrotizing granulomatous vasculitis of the upper and lower respiratory tract and glomerulonephritis. Antineutrophil cytoplasmic antibody-cytoplasmic pattern is a sensitive and relatively specific marker for active Wegener's granulomatosis. We describe a patient whose presentation was superficially suggestive of Wegener's granulomatosis and who had high levels of antibodies directed against proteinase-3 and myeloperoxidase but ultimately was found to have high grade non-Hodgkin's lymphoma.
Zuckerman
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Division of Rheumafologv and the Department of Internal Medicine, the Graduate ospital, Philadelphia, Pennsylvnia.
Leventhal
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Wynne
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