title: An in vivo evaluation of induction of abnormal sperm morphology by ivermectin MSD (Mectizan).
abstract: The in vivo effects of orally administered ivermectin (Mectizan) on sperm head morphology of albino mice were evaluated. Four different dose levels of 0.25, 0.5, 1.0 and 1.5 x the human therapeutic dose of 150 g kg(-1) body weight, were administered to the animals. The animals were exposed to a single oral treatment. The sperm of the mice from the cauda epididymes were examined 5 and 7 weeks after treatment. Ivermectin (Mectizan) induced sperm head abnormalities; however, the induction was not significantly elevated above the negative control value. Furthermore, the induction of the sperm head abnormalities was not strictly dose-dependent and there was also no correlation between dose level of administered drug and incidence of abnormal sperms. This indicates that the drug might not be mutagenic.
authors.affiliation: Department of Zoology, University of Lagos, Lagos, Nigeria.
authors.forename: O A
authors.initials: OA
authors.lastname: Otubanjo
authors.forename: A A
authors.initials: AA
authors.lastname: Mosuro
authors.forename: T F
authors.initials: TF
authors.lastname: Ladipo
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007306:Insecticides / Q000494:pharmacology*; D007559:Ivermectin / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009153:Mutagens / Q000494:pharmacology; D013094:Spermatozoa / Q000002:abnormalities* / Q000166:cytology / Q000187:drug effects*
chemical_list: D007306:Insecticides; D009153:Mutagens; D007559:Ivermectin