title: Effect of garlic along with lead acetate administration on lead burden of some tissues in mice.
abstract: Garlic ability to reduce lead burden in body tissues before and during chronic lead toxicity was studied. Eighty mice were divided into 8 groups. Group D received placebo. Groups A1, A2 and A3, respectively received 500, 250 and 125 mg kg(-1) day garlic and Groups B1, B2 and B3, respectively 1/4, 1/8 and 1/16 garlic tablet kg(-1) day in first four weeks and in second four weeks they received 5 mg kg(-1) day lead acetate plus garlic or garlic tablet. Group C received placebo in first four weeks and in second four weeks they received 5 mg kg(-1) day lead acetate and placebo. Reduction in lead burden of kidney, liver, bone and blood (except for group A3) in experimental groups was significant compared with group C (p<0.05). Results showed that fresh garlic extract and garlic tablet had almost same effects on lead reduction in tissues.
authors.affiliation: School of Veterinary Medicine, Shahrekord University, Shahrekord, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Pourjafar
authors.forename: P A
authors.initials: PA
authors.lastname: Aghbolaghi
authors.forename: M
authors.initials: M
authors.lastname: Shakhse-Niaie
mesh_terms: D000818:Animals; D001822:Body Burden; D001842:Bone and Bones / Q000378:metabolism; D005737:Garlic; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D009942:Organometallic Compounds / Q000097:blood / Q000378:metabolism / Q000633:toxicity*
chemical_list: D009942:Organometallic Compounds; C008261:lead acetate