title: Serum adiponectin concentrations correlate with severity of rheumatoid arthritis evaluated by extent of joint destruction.
abstract: Adiponectin is a hormone released by adipose tissue with antidiabetic, antiatherogenic, and anti-inflammatory properties. The present observational study focused on the relation between serum adiponectin level and the disease severity of established rheumatoid arthritis (RA). Ninety patients with more than 5-year diagnosis of RA and 42 age- and BMI-matched control were enrolled. The severity of RA was evaluated according to the number of destructed joints of overall 68 joints on plain radiographs (37 patients had mild RA and 53 had severe RA). Serum adiponectin level was significantly higher in the severe RA group (17.7+/-6.7 microg/ml) than in the control (9.1+/-3.8 microg/ml) and mild RA groups (13.9+/-6.5 microg/ml) (control vs. mild RA group, P<0.001; mild RA vs. severe RA group, P<0.01). These results suggest that increased number of joint destruction is associated with hyperadiponectinemia in established RA patients.
authors.affiliation: Department of Orthopaedics, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Ebina
authors.forename: Atsunori
authors.initials: A
authors.lastname: Fukuhara
authors.forename: Wataru
authors.initials: W
authors.lastname: Ando
authors.forename: Makoto
authors.initials: M
authors.lastname: Hirao
authors.forename: Tadashi
authors.initials: T
authors.lastname: Koga
authors.forename: Kazuya
authors.initials: K
authors.lastname: Oshima
authors.forename: Morihiro
authors.initials: M
authors.lastname: Matsuda
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Maeda
authors.forename: Tadashi
authors.initials: T
authors.lastname: Nakamura
authors.forename: Takahiro
authors.initials: T
authors.lastname: Ochi
authors.forename: Iichiro
authors.initials: I
authors.lastname: Shimomura
authors.forename: Hideki
authors.initials: H
authors.lastname: Yoshikawa
authors.forename: Jun
authors.initials: J
authors.lastname: Hashimoto
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000503:physiopathology*; D015992:Body Mass Index; D016022:Case-Control Studies; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007249:Inflammation; D007596:Joints / Q000276:immunology / Q000503:physiopathology*; D008875:Middle Aged; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D052242:Adiponectin