Theileria apicoplast as a target for chemotherapy.
Theileria parasites cause severe bovine disease and death in a large part of the world. These apicomplexan parasites possess a relic plastid (apicoplast), whose metabolic pathways include several promising drug targets. Putative inhibitors of these targets were screened, and we identified antiproliferative compounds that merit further characterization.
Lizundia
Regina
R
Département Maladies Infectieuses, Laboratoire de Biologie Cellulaire Comparative des Apicomplexes, UMR 8104 CNRS/U567 INSERM, Hôpital Cochin-Bâtiment Gustave Roussy, Institut Cochin, Paris, France.
Werling
Dirk
D
Langsley
Gordon
G
Ralph
Stuart A
SA
D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D002417:Cattle; D016503:Drug Delivery Systems; D020128:Inhibitory Concentration 50; D008954:Models, Biological; D018087:Plastids / Q000187:drug effects / Q000378:metabolism*; D016794:Theileria / Q000187:drug effects* / Q000378:metabolism*; D013801:Theileriasis / Q000188:drug therapy* / Q000378:metabolism / Q000469:parasitology
D000981:Antiprotozoal Agents