title: Prediction of Colles' fracture load in human radius using cohesive finite element modeling.
abstract: Osteoporotic and age-related fractures are a significant public health problem. One of the most common osteoporotic fracture sites in the aging population is distal radius. There is evidence in the literature that distal radius fractures (Colles' fracture) are an indicative of increased risk of future spine and hip fractures. In this study, a nonlinear fracture mechanics-based finite element method is applied to human radius to assess its fracture load as a function of cortical bone geometry and material properties. Seven three-dimensional finite element models of radius were created and the fracture loads were determined by using cohesive finite element modeling which explicitly represents the crack and the fracture process zone behavior. The fracture loads found in the simulations (731-6793 N) were in the range of experimental values reported in the literature. The fracture loads predicted by the simulations decreased by 4-5% per decade based only on material level changes and by 6-20% per decade when geometrical changes were also included. Cortical polar moment of inertia at 15% distal radius showed the highest correlation to fracture load (r(2)=0.97). These findings demonstrate the strength of fracture mechanics-based finite element modeling and show that combining geometrical and material properties provides a better assessment of fracture risk in human radius.
authors.affiliation: Department of Mechanical Engineering, Villanova University, Villanova, PA 19085, USA. ani.ural@villanova.edu
authors.forename: Ani
authors.initials: A
authors.lastname: Ural
mesh_terms: D003100:Colles' Fracture / Q000473:pathology* / Q000503:physiopathology*; D020342:Finite Element Analysis; D006801:Humans; D008954:Models, Biological; D016474:Weight-Bearing