title: Total serum IgE levels are associated with ambient ozone concentration in asthmatic adults.
abstract: BACKGROUND
  Effects of air pollution exposure on IgE-mediated response in asthmatics are poorly investigated. The aim was to examine the relationship between air pollution concentrations and total IgE levels in adult asthmatics.
  
  
  METHODS
  The present study relates to the 369 asthmatic adults from the French Epidemiological study on Genetics and Environment of Asthma (EGEA), with availability of data on both total serum IgE measurements and air pollution concentrations. Geo-statistical models were performed on 4 x 4 km grids to assess individual outdoor air pollution exposure. Annual outdoor concentrations of ozone (O(3)), nitrogen dioxide (NO(2)), sulphur dioxide (SO(2)), and particulate matter smaller than 10 microm size (PM(10)), and concentrations of summer ozone were assigned to subject's home address.
  
  
  RESULTS
  The geometric mean of total IgE was 161 IU/ml and the average of O(3) exposure was 44.9 +/- 9.5 microg/m(3). Ozone concentrations were positively related to total IgE levels and an increase of 10 microg/m(3) of O(3) resulted in an increase of 20.4% (95% CI = 3.0-40.7) in total IgE levels. Adjustment for age, gender, smoking habits and previous life in the countryside did not change the results, and an increase of 19.1% (2.4-38.6) in total IgE was observed with O(3). Negative associations observed between NO(2) and total IgE levels disappeared after including O(3) in the models. Neither SO(2) nor PM(10) were correlated with total IgE levels.
  
  
  CONCLUSIONS
  Results suggest that O(3) or related ambient pollutants may up-regulate total IgE levels among asthmatic adults.
authors.affiliation: Inserm, U780, Epidemiology and Biostatistics, Villejuif, France.
authors.forename: E
authors.initials: E
authors.lastname: Rage
authors.forename: B
authors.initials: B
authors.lastname: Jacquemin
authors.forename: R
authors.initials: R
authors.lastname: Nadif
authors.forename: M-P
authors.initials: MP
authors.lastname: Oryszczyn
authors.forename: V
authors.initials: V
authors.lastname: Siroux
authors.forename: I
authors.initials: I
authors.lastname: Aguilera
authors.forename: F
authors.initials: F
authors.lastname: Kauffmann
authors.forename: N
authors.initials: N
authors.lastname: Künzli
mesh_terms: D000328:Adult; D000397:Air Pollution / Q000009:adverse effects; D001249:Asthma / Q000453:epidemiology / Q000209:etiology / Q000276:immunology*; D005192:Family Health; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010083:Oxidants, Photochemical / Q000009:adverse effects; D010126:Ozone / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D010083:Oxidants, Photochemical; D007073:Immunoglobulin E; D010126:Ozone