title: Rare tautomers of 1-methyluracil and 1-methylthymine: tuning relative stabilities through coordination to PtII complexes.
abstract: We have computationally explored how the relative stabilities of 1-methyluracil (1-MeUH) tautomers can be tuned through coordination of these tautomers to Pt(II) complexes with a particular set of ligands. This has been done using density functional theory at the BP86/TZ2P level. Thus, we have examined the water/1-MeUH exchange reactions of [Pt(II)(A)(B)(C)(OH(2))](q) + 1-MeUH to uncover: i) which tautomers are best stabilized by the Pt(II) complex, and ii) how the net charge q in the complex affects the reaction energy. The net charge q depends on the ligands A, B, and C, which can be the neutral NH(3) or anionic Cl(-). To reveal the effect of solvation, all reaction systems are studied both in the gas phase and in water. Also the stabilization of tautomers of 1-methylthymine (1-MeTH) by cisplatin is investigated. The calculations reveal that relative energies of the metal (here: Pt(II))-complexed forms of the various tautomers (here: of 1-MeUH and 1-MeTH) do not parallel those of the free tautomers. Rather, a rare nucleobase tautomer, despite its low natural abundance, may become favored over the predominant one when complexed to a metal ion.
authors.affiliation: Fakultät Chemie, Technische Universität Dortmund, Otto-Hahn-Strasse 6, 44221 Dortmund, Germany.
authors.forename: Tushar
authors.initials: T
authors.lastname: van der Wijst
authors.forename: Célia
authors.initials: C
authors.lastname: Fonseca Guerra
authors.forename: Marcel
authors.initials: M
authors.lastname: Swart
authors.forename: F Matthias
authors.initials: FM
authors.lastname: Bickelhaupt
authors.forename: Bernhard
authors.initials: B
authors.lastname: Lippert