[Lymphoma-like lesions of the endometrium].
Chronic endometritis is a rare entity characterized by an endometrial plasmocytic infiltrate. The lymphoid infiltrate may be abundant and simulate a lymphoma of the uterus. We report two cases of lymphoma-like lesions of the endometrium in two postmenopausal women of 79 and 89 year-old, who presented with abundant vaginal discharge. Ultrasound examination revealed in both cases an intrauterin polypoid lesion. Histologically, a predominantly plasmocytic infiltrate was seen in the endometrium destroying endometrial glandes and extending into the superficial myometrium, in the first case. Immunohistochemical study showed a polymorphic lymphoid infiltrate with a predominance of Tcells. Molecular study revealed a polyclonalB cell population, distinguishing the lesion from a marginal zone lymphoma. Lymphoma-like lesions of female genital tract must be distinguished from malignant lymphoma that rarely occurs in this site.
Gaillot
Lucie
L
Service d'anatomie et cytologie pathologiques des hôpitaux Nord, centre de biologie et pathologie Nord, hôpital de la Croix-Rousse, 103 Grande-Rue de la Croix-Rousse, 69317 Lyon cedex 04, France.
Allias
Fabienne
F
Dubernard
Gil
G
Berger
Françoise
F
Devouassoux-Shisheboran
Mojgan
M
D000368:Aged; D000369:Aged, 80 and over; D001402:B-Lymphocytes / Q000473:pathology; D003937:Diagnosis, Differential; D004717:Endometrium / Q000473:pathology*; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000473:pathology*; D017698:Postmenopause; D013601:T-Lymphocytes / Q000473:pathology; D014594:Uterine Neoplasms / Q000473:pathology