Candidate genes for temporal lobe epilepsy: a replication study.
The objective of this study is to replicate previously published results regarding the involvement of several susceptibility genes in temporal lobe epilepsy (TLE): interleukin 1beta (IL-1beta), interleukin 1beta (IL-1alpha), interleukin 1RA (IL-1RA), apolipoprotein E (ApoE) and prodynorphin (PDYN). We used a case-control approach comparing several polymorphisms within these candidate genes between unrelated TLE patients and matched controls. We were thus able to confirm the role of ApoE, IL-1alpha and IL-1RA genes in TLE disease, but failed to confirm the involvement of IL-1beta and PDYN. This failure should be interpreted with caution, as this may be due to the small size of our study groups and the resultant lack of statistical power.
Salzmann
Annick
A
Division of Medical Genetics, University Hospitals of Geneva, Geneva, Switzerland.
Perroud
Nader
N
Crespel
Arielle
A
Lambercy
Carmen
C
Malafosse
Alain
A
D000293:Adolescent; D000328:Adult; D001057:Apolipoproteins E / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D015331:Cohort Studies; D004252:DNA Mutational Analysis; D004745:Enkephalins / Q000235:genetics*; D004833:Epilepsy, Temporal Lobe / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D005787:Gene Frequency; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics; D053582:Interleukin-1alpha / Q000235:genetics; D053583:Interleukin-1beta / Q000235:genetics; D007378:Interleukins / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics; D011498:Protein Precursors / Q000235:genetics*
D001057:Apolipoproteins E; D004745:Enkephalins; D005819:Genetic Markers; D053590:Interleukin 1 Receptor Antagonist Protein; D053582:Interleukin-1alpha; D053583:Interleukin-1beta; D007378:Interleukins; D011498:Protein Precursors; C033660:preproenkephalin