[Mixed vaginitis prevalence in Latin-American women, according to physician perception. Preference, effectiveness and security of clindamycin plus ketoconazole].
BACKGROUND
Vaginitis is an inflammatory process in vaginal mucosa that affects millions of woman worldwide.


OBJECTIVE
To evaluate prevalence perception and prescription preference among Latin-American gyneco-obstetricians in mixed vaginitis, and to identify attributes of various active principles.


METHODS
multicentric and transversal study during January 2008. Close Up was used to poll gyneco-obstetricians prescribing clyndamicin plus ketoconazole. 1,198 gyneco-obstetricians were selected to answer a poll (scales and measuring attributes) to identify differences among various therapeutic schemes to mixed vaginitis.


RESULTS
34% of gyneco-obstetricians consider that 30 to 50% of them patients had mixed vaginitis, 38% consider a 50 to 70% of its prevalence, and 20% a 70% or higher figure. In a bad to excellent scale, 97% had very good to excellent results with antimycotic and antibacterial mix, 73% had a bad to good result with antimycotics alone and 79% with antibacterial alone. Clyndamicin plus ketoconazole had a meaningful difference from mean results (standard), and from the second best mix (metronidazole plus nystatin), with a rapid itch healing, efficacy, and relapse decrease. Metronidazole plus nystatin had the highest score in tolerance and treatment period.


CONCLUSIONS
90% of polled Latin-American obstetricians prescribe clyndamicin plus ketoconazole as the best available treatment to mixed vaginitis.
Hernández Bueno
José Alberto
JA
Clínica de Atención Médica Integral para la Mujer SC, Naucalpan, Estado de México, México. jhernandezb@atmim.com
Vázquez Alanís
Alejandro
A
Olguín Ramírez
Claudia
C
Dumet Hinostroza
Pablo F
PF
Gutiérrez Ramos
Miguel
M
De Zordo
Daniel
D
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D002981:Clindamycin / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use*; D007843:Latin America / Q000453:epidemiology; D010818:Practice Patterns, Physicians'; D015995:Prevalence; D014627:Vaginitis / Q000188:drug therapy* / Q000453:epidemiology*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D004338:Drug Combinations; D002981:Clindamycin; D007654:Ketoconazole