Bemiparin improves the total antioxidant status in plasma.
The aim of this work is to test the protective effect of bemiparin (3500 I.U., s.c.) against oxidative stress in plasma from healthy volunteers. We have evaluated the total antioxidant activity in plasma, superoxide dismutase and glutathione peroxidase activities, and oxidized glutathione and malondialdehyde levels, in two groups: treated (n=20) and control (n=15). Blood samples were collected at: basal, 2, 4, 6, 8 and 10 h. Total antioxidant activity and antioxidant enzymes activity were higher in the treated group at 2-6 h. However, oxidized glutathione and malondialdehyde levels were lower in the treated group at same times. The results suggest that bemiparin exerts an early beneficial effect against oxidative stress in plasma.
García-de-la-Asunción
José
J
Department of Anesthesiology and Critical Care, Hospital Clínico Universitario de Valencia, Valencia, Spain. jgdelaasuncion@hotmail.com
de Toro
Paula
P
Planelles
Verónica
V
Belda
Javier
J
Perez-Griera
Jaime
J
Gambini
Juan
J
Domenech
Elena
E
D000328:Adult; D000975:Antioxidants / Q000032:analysis / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood / Q000378:metabolism; D006262:Health; D006495:Heparin, Low-Molecular-Weight / Q000097:blood* / Q000494:pharmacology*; D006801:Humans; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism
D000975:Antioxidants; D015415:Biomarkers; D006495:Heparin, Low-Molecular-Weight; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; C411345:bemiparin