title: Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ.
abstract: 3-Methoxybenzamide is a weak inhibitor of the essential bacterial cell division protein FtsZ. Exploration of the structure-activity relationships of 3-methoxybenzamide analogues led to the identification of potent anti-staphylococcal compounds.
authors.affiliation: Prolysis Ltd, Begbroke Science Park, Sandy Lane, Yarnton, Oxfordshire OX5 1PF, UK.
authors.forename: Lloyd G
authors.initials: LG
authors.lastname: Czaplewski
authors.forename: Ian
authors.initials: I
authors.lastname: Collins
authors.forename: E Andrew
authors.initials: EA
authors.lastname: Boyd
authors.forename: David
authors.initials: D
authors.lastname: Brown
authors.forename: Stephen P
authors.initials: SP
authors.lastname: East
authors.forename: Mihaly
authors.initials: M
authors.lastname: Gardiner
authors.forename: Rowena
authors.initials: R
authors.lastname: Fletcher
authors.forename: David J
authors.initials: DJ
authors.lastname: Haydon
authors.forename: Vincent
authors.initials: V
authors.lastname: Henstock
authors.forename: Peter
authors.initials: P
authors.lastname: Ingram
authors.forename: Clare
authors.initials: C
authors.lastname: Jones
authors.forename: Caterina
authors.initials: C
authors.lastname: Noula
authors.forename: Leanne
authors.initials: L
authors.lastname: Kennison
authors.forename: Chris
authors.initials: C
authors.lastname: Rockley
authors.forename: Valerie
authors.initials: V
authors.lastname: Rose
authors.forename: Helena B
authors.initials: HB
authors.lastname: Thomaides-Brears
authors.forename: Rebecca
authors.initials: R
authors.lastname: Ure
authors.forename: Mark
authors.initials: M
authors.lastname: Whittaker
authors.forename: Neil R
authors.initials: NR
authors.lastname: Stokes
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors*; D001549:Benzamides / Q000737:chemistry / Q000494:pharmacology*; D003598:Cytoskeletal Proteins / Q000037:antagonists & inhibitors*; D008826:Microbial Sensitivity Tests; D013210:Staphylococcus / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D001549:Benzamides; D003598:Cytoskeletal Proteins; C071525:FtsZ protein, Bacteria; C025159:3-methoxybenzamide