title: Statistical evaluation of the in vivo micronucleus assay.
abstract: The statistical evaluation of the in vivo micronucleus assay is focused on multiple contrast tests for comparisons versus the negative control for count data taking the between-animals variability into account. For a possible claim the compound is not genotoxic in the micronucleus assay a proof of safety approach is proposed. For these statistical approaches user-friendly software is free available.
authors.affiliation: Institute of Biostatistics, Leibniz University, Herrenhauser Str. 2, 30419 Hannover, Germany. hothorn@biostat.uni-hannover.de
authors.forename: Ludwig A
authors.initials: LA
authors.lastname: Hothorn
authors.forename: Daniel
authors.initials: D
authors.lastname: Gerhard
mesh_terms: D000818:Animals; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D005260:Female; D008297:Male; D051379:Mice; D015162:Micronucleus Tests / Q000379:methods; D015233:Models, Statistical; D009153:Mutagens / Q000633:toxicity*; D012984:Software
chemical_list: D009153:Mutagens