[Clinical symptom relief in obese patients with persistent moderate asthma secondary to decreased obesity].
BACKGROUND
The prevalence of asthma and obesity has increased last years implying important economical and social consequences. A relationship between asthma severity and obesity grade has been found. Therefore, it is necessary to evaluate if obesity decline has a beneficial impact on asthma severity.


OBJECTIVE
To evaluate the effect of obesity decline on control symptoms and asthma severity.


METHODS
Ninety-six patients with obesity and moderate chronic asthma were randomized to group A or B and were maintained for 40 days on a low calorie diet. At baseline and at the end of the study, symptoms, measurement of obesity, spirometry, inflammatory cytokines and immunoglobulin's levels were assessed. Diets' safety was evaluated based on laboratory test. Data were analyzed with Student's t test.


RESULTS
After 40 days on a low calorie diet, in group A, there were significant decreases of obesity (p < 0.001) and IgE, symptoms almost disappeared (cough persisted in 20%) and medication was suspended in 80%. Group B had obesity decline but IgE levels remained (> 100 UI/mL), symptoms and drug regimen remained unchanged. Both diets were not harmful for patients.


CONCLUSIONS
These results show that asthmatic obese patients maintained for 40 days on low calorie diet A, had obesity and IgE levels decrease and symptoms and asthma severity relief.
Hernández Romero
Azael
A
Departamento de laboratorio clínico y bioestadistica, Unidad Médica de Alta Especialidad, Hospital de Especialidades, Centro Médico Nacional Siglo XXI.
Matta Campos
Juan
J
Mora Nieto
Alejandra
A
del Rivero
Leonel
L
Andrés Dionicio
Atenea Estela
AE
Aguilar Ramírez
Pilar
P
Barthell Solís
Carlos
C
García González
América
A
Carreta Macías
Leticia
L
Murguía Corral
Ricardo
R
Vázquez Nava
Francisco
F
Almeida Arvizu
Víctor Manuel
VM
D000293:Adolescent; D000328:Adult; D000368:Aged; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use; D001249:Asthma / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D016207:Cytokines / Q000097:blood; D004038:Diet, Reducing; D002149:Energy Intake; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000178:diet therapy* / Q000503:physiopathology; D011446:Prospective Studies; D013147:Spirometry; D015431:Weight Loss
D018927:Anti-Asthmatic Agents; D016207:Cytokines; D007136:Immunoglobulins; D007073:Immunoglobulin E