Biotransformation of the marine sesquiterpene pacifenol by a facultative marine fungus.
Continued investigation of the marine alga Laurencia claviformis has led to the isolation of pacifenol, a halogenated sesquiterpene as the major metabolite. The microbial transformation of pacifenol is reported. It was cultivated with a marine strain of Penicillium brevicompactum yielding a new compound. The structure was elucidated on the basis of spectroscopic data. The anti-microbial activity of pacifenol derivatives is reported.
San-Martín
Aurelio
A
Departamento de Quimica, Facultad de Ciencias, Universidad de Chile, Santiago, Chile. aurelio@uchile.cl
Rovirosa
Juana
J
Astudillo
Luis
L
Sepúlveda
Beatriz
B
Ruiz
Daniela
D
San-Martín
Carol
C
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001711:Biotransformation; D004926:Escherichia coli / Q000187:drug effects; D044722:Laurencia / Q000737:chemistry* / Q000382:microbiology; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010407:Penicillium / Q000378:metabolism; D011514:Proteus vulgaris / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013210:Staphylococcus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D012717:Sesquiterpenes; C094445:pacifenol