title: Stem cells in the trabecular meshwork: present and future promises.
abstract: Primary open-angle glaucoma is recognized as a disease of aging, and studies show a relationship between aging and trabecular meshwork (TM) cell density. Human TM cell division occurs primarily in the anterior, non-filtering region. A commonly used glaucoma treatment, laser trabeculoplasty (LTP), triggers and increases cell division, as well as cell migration of these anterior TM cells. These freshly-divided migrating cells repopulate the burned laser sites, suggesting that they are stem cells. Several studies concerning this putative TM stem cell will be discussed.
authors.affiliation: Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA. kelleyma@ohsu.edu
authors.forename: M J
authors.initials: MJ
authors.lastname: Kelley
authors.forename: A Y
authors.initials: AY
authors.lastname: Rose
authors.forename: K E
authors.initials: KE
authors.lastname: Keller
authors.forename: H
authors.initials: H
authors.lastname: Hessle
authors.forename: J R
authors.initials: JR
authors.lastname: Samples
authors.forename: T S
authors.initials: TS
authors.lastname: Acott
mesh_terms: D005902:Glaucoma, Open-Angle / Q000473:pathology* / Q000601:surgery; D006801:Humans; D053685:Laser Therapy; D012038:Regeneration; D013234:Stem Cells / Q000473:pathology*; D014129:Trabecular Meshwork / Q000473:pathology* / Q000502:physiology; D014130:Trabeculectomy