title: 60-year old woman with extra-axial frontal mass.
abstract: We describe a 60 year-old woman presenting with visual loss of her left eye. No lymphadenopathies, fever, or weight loss were detected. Neuroimaging studies revealed an extra-axial mass along the posterior aspect of the left optic nerve. The mass was resected and showed xanthomatous histiocytes that were positive for CD-68, occasionally positive for S-100, and negative for CD-1. The lesion was diagnosed as Erdheim-Chester disease (ECD) affecting the CNS. The patient is under systemic evaluation in order to discover other ECD lesions. Microscopic findings and differential diagnoses are discussed.
authors.forename: Naomi
authors.initials: N
authors.lastname: Arakaki
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Riudavets
authors.forename: Andrés
authors.initials: A
authors.lastname: Cervio
authors.forename: Marcelo
authors.initials: M
authors.lastname: Ferreira
authors.forename: Gustavo
authors.initials: G
authors.lastname: Sevlever
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D001766:Blindness / Q000209:etiology*; D003937:Diagnosis, Differential; D031249:Erdheim-Chester Disease / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D005260:Female; D006644:Histiocytes / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D019574:Optic Nerve Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D009418:S100 Proteins / Q000032:analysis; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D009418:S100 Proteins; C067980:CD68 antigen, human; D000097382:CD68 Molecule