Molecular analysis of the sequences surrounding blaOXA-45 reveals acquisition of this gene by Pseudomonas aeruginosa via a novel ISCR element, ISCR5.
The bla(OXA-45) gene of Pseudomonas aeruginosa 07-406 is driven by a promoter found within a truncated ISPme1 insertion sequence. The gene is located between nonidentical repeats of a new ISCR element, ISCR5, which is likely responsible for its acquisition. Sequence analysis indicates that ISCR5 is a chimera of ISCR3 and ISCR16.
Li
Hongyang
H
Department of Medical Microbiology, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom.
Walsh
Timothy R
TR
Toleman
Mark A
MA
D001483:Base Sequence; D018387:Codon, Initiator; D017931:DNA Primers; D004251:DNA Transposable Elements / Q000235:genetics*; D004269:DNA, Bacterial / Q000235:genetics; D030541:Databases, Genetic; D030562:Databases, Protein; D005798:Genes, Bacterial; D006801:Humans; D008957:Models, Genetic; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D011550:Pseudomonas aeruginosa / Q000235:genetics* / Q000302:isolation & purification; D012689:Sequence Homology, Nucleic Acid; D001618:beta-Lactamases / Q000235:genetics*
D018387:Codon, Initiator; D017931:DNA Primers; D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D001618:beta-Lactamases