Fibroblast mechanics in three-dimensional collagen matrices.
Fascia provides mechanical support and frameworks for the other tissues of the body. Type 1 collagen is the major protein component of fascia, and fibroblasts are the cell type primarily responsible for its biosynthesis and remodeling. Research on fibroblasts interacting with collagen matrices provides new insights regarding how cell-matrix tension state and growth factor specificity regulate cell migration and matrix remodeling.
Grinnell
Frederick
F
Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390-9039, USA. frederick.grinnell@utsouthwestern.edu
D000818:Animals; D002465:Cell Movement / Q000502:physiology; D003094:Collagen / Q000502:physiology*; D005205:Fascia / Q000166:cytology* / Q000502:physiology*; D005347:Fibroblasts / Q000502:physiology*; D006801:Humans; D013718:Tensile Strength / Q000502:physiology*
D003094:Collagen