title: Prevalence of cagA in relation to clinical presentation of Helicobacter pylori infection in Egypt.
abstract: Helicobacter pylori infection, peptic ulcer and gastric cancer are common problems in Egypt. We investigated the prevalence of cagA-positive Helicobacter pylori infections among Egyptian adults in relation to presentation (e.g. dyspepsia vs asymptomatic controls) in Minofyia, Egypt. Patients included men or women seeking care for at least 3 months of upper gastrointestinal symptoms. Helicobacter pylori status was determined by rapid urease test and gastric histopathology in patients and by anti-Helicobacter pylori IgG antibodies in controls. CagA status was determined using an anti-cag A ELISA. 99 Helicobacter pylori infected patients were entered including 90 dyspeptic patients (30 each with gastric cancer, peptic ulcer, and non-ulcer dyspepsia) and 9 non-dyspeptic healthy controls. Age ranged from 27 to 78 y (mean 49.5 y); 50% were men. Anti-cagA antibodies were present in 62.2% of dyspeptic patients compared with 11% of asymptomatic controls (p = 0.004). Anti-cagA antibodies were more prevalent among dyspeptic patients with gastric cancer or peptic ulcer (73.3%) compared to those with non-ulcer dyspepsia (40%) (p = 0.004). The prevalence of cagA in Egypt was related to the clinical presentation of Helicobacter pylori infection being lowest in asymptomatic controls (11.1%) and increasingly prevalent in non-ulcer dyspepsia (40%), peptic ulcer (66.7%), and gastric cancer (89%).
authors.affiliation: Department of Tropical Medicine and Biochemistry Department, Minofyia University, Minofyia, Egypt.
authors.forename: Abdallah
authors.initials: A
authors.lastname: Said Essa
authors.forename: Mohammed
authors.initials: M
authors.lastname: Alaa Eldeen Nouh
authors.forename: Naglaa
authors.initials: N
authors.lastname: Mohammed Ghaniam
authors.forename: David Y
authors.initials: DY
authors.lastname: Graham
authors.forename: Hany
authors.initials: H
authors.lastname: Said Sabry
mesh_terms: D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood; D000942:Antigens, Bacterial / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism*; D004415:Dyspepsia / Q000453:epidemiology / Q000378:metabolism / Q000382:microbiology; D004534:Egypt / Q000453:epidemiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016481:Helicobacter Infections / Q000453:epidemiology* / Q000382:microbiology / Q000503:physiopathology*; D016480:Helicobacter pylori / Q000276:immunology / Q000378:metabolism / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000453:epidemiology / Q000378:metabolism / Q000382:microbiology; D015995:Prevalence; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000378:metabolism / Q000382:microbiology
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C080866:cagA protein, Helicobacter pylori