title: Pharmacogenetic contribution of leptin gene polymorphism in cutaneous T-cell lymphoma.
abstract: Leptin has recently attracted more attention due to its specific effects in the pathogenesis of malignancies. The aim of this study was to investigate the possible association between variants of -2548 G/A polymorphism in leptin (LEP) gene and cutaneous T-cell lymphomas (CTCL), with respect to the treatment responsiveness. A sample of 91 patients with CTCL was compared to 198 control individuals. The CTCL men with AG and/or GG genotype were more likely to receive the topical steroids treatment (odds ratio 7.88, 95% confidential interval 1.51-41.04) when compared to AA patients. Our data supports the possible involvement of LEP-2548G/A polymorphism in CTCL treatment responsiveness and thus might provide important information for individual therapy tailoring.
authors.affiliation: First Department of Dermatology, St. Ann's Faculty Hospital, Masaryk University, Brno, Czech Republic.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Vasku
authors.forename: Anna
authors.initials: A
authors.lastname: Vasku
authors.forename: Julie Bienertova
authors.initials: JB
authors.lastname: Vasku