Humanizing a mouse gene for human therapeutics: lessons from denosumab.
Little
David Graham
DG
Orthopaedic Research and Biotechnology, The Children's Hospital at Westmead, Westmead, New South Wales, Australia. davidl3@chw.edu.au
D000135:Acid Phosphatase / Q000097:blood; D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D002986:Clinical Trials as Topic; D000069448:Denosumab; D050723:Fractures, Bone / Q000188:drug therapy; D005818:Genetic Engineering; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D051379:Mice; D053245:RANK Ligand / Q000378:metabolism / Q000627:therapeutic use*; D000071681:Tartrate-Resistant Acid Phosphatase
D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D007527:Isoenzymes; D053245:RANK Ligand; D000069448:Denosumab; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase