title: [Clinical value of protoparaxotril saporlirs combined with aspirin in the secondary prevention of cerebral infarction].
abstract: OBJECTIVE
  To observe the clinical value of protoparaxotril saporlirs (PTS) combined with aspirin in the secondary prevention of cerebral infarction.
  
  
  METHODS
  The 140 patients with cerebral infarction were collected, among them the 120 patients during recovery stage were equally assigned to three groups by randomized, single blinded and open controlled principle, and they were treated respectively by PTS (A), aspirin (B), and PTS plus aspirin (C) for 6 months. The other 20, who couldn't or were unwilling to use aspirin, were arranged in group D for control. The platelet aggregation rate, incidence of stroke recurrence, gastrointestinal adverse reaction and the NIHSS scores of patients were observed during the six-month period of treatment.
  
  
  RESULTS
  As compared with group D, the lowering amplitude of platelet aggregation rate after treatment in the three treatment groups were significantly higher (P < 0.01). Comparison of platelet aggregation rate between group A and B showed significant difference after 3-month treatment (P < 0.05), but the difference became insignificant after 6-month treatment (P > 0.05). The incidence of stroke recurrence in the group A, B and C was 18.9%, 13.2% and 10.8% respectively, which showed no significant difference among them, but all were significantly lower than that in the group D (44.4%, P < 0.05). NIHSS scores in group A and C were significantly lower than in group B (P < 0.01); and the occurrence of gastrointestinal reaction was significantly lower in group A (P < 0.01).
  
  
  CONCLUSIONS
  Long-term application of PTS has the effects for preventing stroke recurrence, lowering gastrointestinal adverse reaction and improving patients' neural function in patients with stroke. As used in combination with aspirin, it shows potential practical importance in the clinical secondary prevention of stroke.
authors.affiliation: Department of Neurology, the Third Hospital Affiliated to Guangzhou Medical College, Guangzhou. zhoubr8@yahoo.com.cn
authors.forename: Bo-rong
authors.initials: BR
authors.lastname: Zhou
authors.forename: Zhi-qiang
authors.initials: ZQ
authors.lastname: Xu
authors.forename: Zi-fan
authors.initials: ZF
authors.lastname: Liu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001241:Aspirin / Q000008:administration & dosage* / Q000009:adverse effects; D002544:Cerebral Infarction / Q000188:drug therapy / Q000503:physiopathology / Q000517:prevention & control*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D012502:Sapogenins / Q000008:administration & dosage* / Q000009:adverse effects; D055502:Secondary Prevention
chemical_list: D012502:Sapogenins; C081552:protopanaxatriol; D001241:Aspirin