title: Case-control study of green tea consumption and the risk of endometrial endometrioid adenocarcinoma.
abstract: OBJECTIVE
  To investigate the association between green tea consumption and the risk of endometrial cancer restricted to endometrial endometrioid adenocarcinoma (EEA) using a case-control design in Japan.
  
  
  METHODS
  The cases were 152 patients with histopathologically diagnosed EEA, and the controls were 285 healthy women who were matched for age and area of residence with individual cases. The subjects completed a questionnaire regarding health-related lifestyle and reproductive history, and a food frequency questionnaire. Odds ratios (ORs) of EEA for frequency of green tea consumption were calculated by conditional logistic regression analysis.
  
  
  RESULTS
  We observed a significant inverse association between green tea consumption and the risk of EEA with a dose-response relationship. The multivariate-adjusted OR of EEA was 0.77 (95% CI: 0.37-1.58) for those in the second quartile of green tea consumption (5-6 cups/week-1 cup/day), 0.61 (0.30-1.23) in the third quartile (2-3 cups/day), and 0.33 (0.15-0.75) in the highest quartile (> or = 4 cups/day), as referenced with those in the lowest quartile (< or = 4 cups/week; p for trend = 0.007). This inverse association was consistently observed regardless of the presence or absence of factors such as obesity and menopause.
  
  
  CONCLUSIONS
  Green tea consumption may be associated with a lower risk of EEA.
authors.affiliation: Division of Gynecology, Department of Reproductive and Developmental Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan. qyp06776@nifty.com
authors.forename: Yukika
authors.initials: Y
authors.lastname: Kakuta
authors.forename: Naoki
authors.initials: N
authors.lastname: Nakaya
authors.forename: Satoru
authors.initials: S
authors.lastname: Nagase
authors.forename: Megumi
authors.initials: M
authors.lastname: Fujita
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Koizumi
authors.forename: Chikako
authors.initials: C
authors.lastname: Okamura
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Niikura
authors.forename: Kaori
authors.initials: K
authors.lastname: Ohmori
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kuriyama
authors.forename: Toru
authors.initials: T
authors.lastname: Tase
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Ito
authors.forename: Yuko
authors.initials: Y
authors.lastname: Minami
authors.forename: Nobuo
authors.initials: N
authors.lastname: Yaegashi
authors.forename: Ichiro
authors.initials: I
authors.lastname: Tsuji
mesh_terms: D018269:Carcinoma, Endometrioid / Q000453:epidemiology* / Q000517:prevention & control; D016022:Case-Control Studies; D016889:Endometrial Neoplasms / Q000453:epidemiology* / Q000517:prevention & control; D005260:Female; D006801:Humans; D012307:Risk Factors; D011795:Surveys and Questionnaires; D013662:Tea
chemical_list: D013662:Tea