title: Optimizing distance image quality of an aspheric multifocal intraocular lens using a comprehensive statistical design approach.
abstract: The AcrySof ReSTOR intraocular lens (IOL) is a multifocal lens with state-of-the-art apodized diffractive technology, and is indicated for visual correction of aphakia secondary to removal of cataractous lenses in adult patients with/without presbyopia, who desire near, intermediate, and distance vision with increased spectacle independence. The multifocal design results in some optical contrast reduction, which may be improved by reducing spherical aberration. A novel patent-pending approach was undertaken to investigate the optical performance of aspheric lens designs. Simulated eyes using human normal distributions were corrected with different lens designs in a Monte Carlo simulation that allowed for variability in multiple surgical parameters (e.g. positioning error, biometric variation). Monte Carlo optimized results indicated that a lens spherical aberration of -0.10 microm provided optimal distance image quality.
authors.affiliation: Alcon Laboratories, Inc. 6201 South Freeway, Fort Worth, Texas 76134, USA. Xin.Hong@alconlabs.com
authors.forename: Xin
authors.initials: X
authors.lastname: Hong
authors.forename: Xiaoxiao
authors.initials: X
authors.lastname: Zhang
mesh_terms: D003198:Computer Simulation; D017076:Computer-Aided Design; D019544:Equipment Failure Analysis / Q000379:methods; D006801:Humans; D007910:Lenses, Intraocular; D008954:Models, Biological; D011474:Prosthesis Design / Q000379:methods*; D017755:Prosthesis Fitting / Q000379:methods*; D011786:Quality Control; D012030:Refractive Errors / Q000503:physiopathology* / Q000534:rehabilitation*; D013813:Therapy, Computer-Assisted / Q000379:methods