title: Simple modeling of the physical sample dispersion process in rectangular meso (micro) channels with pressure-driven flows.
abstract: The present paper reports the modeling and characterization of the physical sample dispersion process observed in rectangular microchannels when pressure-driven pumping is used. To explain experimental results provided by the silicon fluidic device constructed, two different mathematical models were tested. The first one is based on the diffusion-convection model, and the second one is based on the combination of ideal reactors. The silicon designed and constructed chip includes a microfluidic manifold with four inlet-outlet ports and a monolithically integrated optical flow cell. The microchannels, the optical flow cell, and the input-output ports were micromachined on a silicon wafer and then sealed with Pyrex glass anodically bonded. Optical windows were integrated in the chip, allowing simple absorbance-transmission measurements. Pressure-driven flows through fluidic channels were controlled via three-way solenoid valves and provided by an automatic microburette operating in aspiration mode. Experimentally obtained results demonstrate that the physical sample dispersion process can be easily modeled as a combination of a continuous stirred tank reactor and a plug-flow reactor.
authors.affiliation: Grup de Sensors i Biosensors, Departament de Química, Facultat de Ciències, Edifici C-Nord, Universitat Autònoma de Barcelona, 08193, Bellaterra (Cerdanyola del Vallès), Spain. mariadelmar.baeza@uab.cat
authors.forename: Mireia
authors.initials: M
authors.lastname: Baeza
authors.forename: José Luis
authors.initials: JL
authors.lastname: Montesinos
authors.forename: Julián
authors.initials: J
authors.lastname: Alonso
authors.forename: Jordi
authors.initials: J
authors.lastname: Bartrolí