The endocrine regulation of aging in Caenorhabditis elegans.
In recent years, there has been significant growth in our understanding of the regulation of longevity. The most notable change is the identification and detailed description of a number of molecular pathways modulating the rate of aging. A good portion of this new data has come from studies using the genetic model organism Caenorhabditis elegans. In this review, we provide an overview of physiological systems that are involved in the modulation of aging in C. elegans, then discuss the known endocrine signaling systems that are likely to couple these systems together. Finally, we present a working model describing how aging may be regulated as a coordinated system, communicating through endocrine signals.
Kleemann
G A
GA
Lewis-Sigler Institute for Integrative Genomics and Dept. of Molecular Biology, Princeton University, 148 Carl Icahn Lab, Washington Road, Princeton, NJ 08544, United States.
Murphy
C T
CT
D000375:Aging / Q000502:physiology*; D000818:Animals; D017173:Caenorhabditis elegans / Q000502:physiology*; D004703:Endocrine System / Q000502:physiology*; D005088:Exocrine Glands / Q000502:physiology; D007328:Insulin / Q000502:physiology; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology; D013256:Steroids / Q000502:physiology
D007328:Insulin; D013256:Steroids; D007334:Insulin-Like Growth Factor I