title: Obesity and diabetes: lipids, 'nowhere to run to'.
abstract: Although specific pathogenic entities contributing to diabetic risk, such as central adiposity, ectopic fat accumulation, hyperlipidaemia and inflammation, are well-characterized, the response of cellular systems to such insults are less well understood. This short review highlights the effect of increasing fat mass on ectopic fat accumulation, the role of triacylglycerols (triglycerides) in Type 2 diabetes mellitus and cardiovascular disease pathogenesis, and selected current therapeutic strategies used to ameliorate these risk factors.
authors.affiliation: Clinical Sciences Research Institute, Warwick Medical School, University Hospitals Coventry and Warwickshire, Coventry CV2 2DX, UK. margaret.hill@warwick.ac.uk
authors.forename: Margaret J
authors.initials: MJ
authors.lastname: Hill
authors.forename: David
authors.initials: D
authors.lastname: Metcalfe
authors.forename: Philip G
authors.initials: PG
authors.lastname: McTernan
mesh_terms: D017667:Adipocytes / Q000473:pathology; D050154:Adiposity / Q000502:physiology; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism; D032383:Myocytes, Cardiac / Q000378:metabolism; D009765:Obesity / Q000150:complications* / Q000378:metabolism; D045162:Thiazolidinediones / Q000627:therapeutic use
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D045162:Thiazolidinediones