Evaluation of infant membrane oxygenator in sheep.
OBJECTIVE
To analyze the security and efficacy of a new membrane oxygenator, the so-called OXM - 1500.


METHODS
From May 2005 to September 2006, six sheep of Santa Inês breed (five male and one female, respectively) were studied. The average body weight was 14.1 (+/-5) kg, body surface 0.6 (+/-0.2) m(2) and a mean age 3.8 (+/-1.5) months. All of them were submitted to extracorporeal circulation (CEC) with evaluation at 10, 30, 60, 120, 180 and 240 minutes. The following values were obtained: values of oxygen transference (TTO2) and carbon dioxide transference (TTCO2), haemoglobin (HBS) and free haemoglobin (HBL), the score of platelets and of leucocytes, and heat transference rate.


RESULTS
TTO2 and TTCO2 were adequate. Lesion of the majority formed blood elements was insignificant; there no modifications in HBS, HBL levels; platelets and leucocytes decreased over time. Heat exchange was effective (p < 0.05).


CONCLUSIONS
The membrane OXM--1500 infant oxygenator, tested in sheep, showed adequate oxygenation capacity, CO2 removal capacity, and small alteration of haemoglobin and platelets without significant decrease of leucocytes, as expected. Heat exchanger connected to the oxygenator was efficient in temperature changes.
Finoti
Renata Geron
RG
Faculdade de Medicina de São José do Rio Preto, Hospital de Base, SP, Brasil. geron@braile.com.br
Braile
Domingo Marcolino
DM
Croti
Ulisses Alexandre
UA
Oliveira
Marcos Aurélio Barboza de
MA
Godoy
Moacir Fernandes de
MF
Leal
João Carlos Ferreira
JC
Policarpo
Sebastião Rodrigues
SR
Lopes
Marden Leonardi
ML
D000818:Animals; D001833:Body Temperature Regulation / Q000502:physiology; D002245:Carbon Dioxide / Q000097:blood; D015199:Extracorporeal Membrane Oxygenation / Q000295:instrumentation*; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007223:Infant; D007958:Leukocyte Count; D008297:Male; D023421:Models, Animal; D010100:Oxygen / Q000097:blood; D010107:Oxygenators, Membrane / Q000592:standards*; D010976:Platelet Count; D017694:Rewarming / Q000295:instrumentation; D012756:Sheep
D006454:Hemoglobins; D002245:Carbon Dioxide; D010100:Oxygen