title: A sequel to the tale of p25/Cdk5 in neurodegeneration.
abstract: p25/Cdk5 dysregulation may contribute to neurodegeneration. In this issue of Neuron, Kim et al. show that cdk5 inactivates HDAC-1, leading to cell cycle deregulation and DNA damage accumulation. This study provides further insights into the function of p25/Cdk5 in neurons and points to HDAC-1 as a target for therapeutic interventions.
authors.affiliation: Department of Neurology, Pathology, and Cell Biology and Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032, USA.
authors.forename: Burcin
authors.initials: B
authors.lastname: Ikiz
authors.forename: Serge
authors.initials: S
authors.lastname: Przedborski
mesh_terms: D000818:Animals; D051360:Cyclin-Dependent Kinase 5 / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D009410:Nerve Degeneration / Q000201:enzymology*
chemical_list: D051360:Cyclin-Dependent Kinase 5