[Analysis of prescription for special disease/syndrome--compatibility of absorbed/metabolized components from original formula--a thinking of research].
What is the pharmacodynamic active components in Chinese medical prescription is a key problem in urgent need to solve for the development of traditional Chinese medicine (TCM). A new thinking of TCM research, "analysis of prescription for special disease/syndrome--compatibility of absorbed/metabolized components from original prescription", was proposed firstly, to analyze and seek out the components or metabolites originated from the administered prescription in blood serum of the organisms with special disease and syndrome. Secondly, to study the compatibility of these absorbed/metabolized components. Then, using a homogeneous design to find out the contribution of each component to the effectiveness of the prescription, eliminate the irrespective or contra-orientation effected components, so as to form the best combination of various components for the prescription with the optimal therapeutic efficacy. By this way, the validity of the prescription with new formed combination could be ensured, not only the predominance and characteristic of combined utilization of traditional Chinese drugs be retained, but also the pharmacodynamic components of the refined prescription be identified, a new prescription with clear pharmacodynamic constitution be obtained and the dispensing relation among various components be explained clearly and quantitatively.
Zhang
Hong-min
HM
The Second Affiliated Hospital of Guangzhou TCM University, Guangdong Provincial Hospital of TCM, Guangdong Provincial Academy of Chinese Medicinal Sciences, Guangzhou. zhm0906@163.com
D035843:Biomedical Research; D004344:Drug Incompatibility; D011307:Drug Prescriptions; D004358:Drug Therapy; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006801:Humans
D004365:Drugs, Chinese Herbal