Subthalamic role on the generation of spikes in temporal epilepsy.
We report the electrophysiological findings in an unusual patient with temporal lobe epilepsy and subthalamic stimulators implanted to treat Parkinson's disease. Temporal and frontotemporal spikes were observed in the EEG. Temporal spikes spread to the STN in a 40% of cases, involving simultaneously all contacts. Frontotemporal spikes showed more frequent STN propagation (70%), shorter delays, and progressive spread from ventral to dorsal contacts than temporal spikes. These results suggest that a direct fronto-subthalamic pathway might account for the fast propagation of the frontotemporal spikes to the ventral STN.
Urrestarazu
Elena
E
Department of Neurology and Neurosurgery, Clínica Universitaria and Medical School, and Neurosciences Division, CIMA University of Navarra, Pamplona, Spain.
Iriarte
Jorge
J
Alegre
Manuel
M
Guridi
Jorge
J
Rodríguez-Oroz
María Cruz
MC
Obeso
José
J
Viteri
César
C
Artieda
Julio
J
D000200:Action Potentials / Q000502:physiology*; D004525:Efferent Pathways / Q000503:physiopathology; D004558:Electric Stimulation / Q000009:adverse effects; D004569:Electroencephalography / Q000379:methods; D004833:Epilepsy, Temporal Lobe / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000628:therapy; D020531:Subthalamic Nucleus / Q000503:physiopathology*