Triprenylated flavonoids from Dorstenia psilurus and their alpha-glucosidase inhibition properties.
Six new unusual C-4'-prenylated flavonols, dorsilurins F-K (1-6), together with six known compounds were isolated from the roots of Dorstenia psilurus, and their structures were elucidated on the basis of spectroscopic evidence. The isolated compounds exhibited moderate to low alpha-glucosidase inhibitory activity. Dorsilurin F (1), with three unmodified prenyl groups, was the most active, while dorsilurin K (6), with only one unmodified prenyl group, was the least active compound. Furthermore, NMR data of dorsilurin C (7), isolated some years ago from the same plant, have been revised.
Tabopda
Turibio K
TK
Organic Chemistry Department, University of Yaoundé I, P.O. Box 8664, Yaoundé, Cameroon. ttabopda@yahoo.fr
Ngoupayo
Joseph
J
Awoussong
Patrice K
PK
Mitaine-Offer
Anne-Claire
AC
Ali
Muhammad S
MS
Ngadjui
Bonaventure T
BT
Lacaille-Dubois
Marie-Aleth
MA
D002163:Cameroon; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D015394:Molecular Structure; D029586:Moraceae / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
D005419:Flavonoids; D065089:Glycoside Hydrolase Inhibitors; C534641:dorsilurin F