title: Intestinal reconstruction of the lower urinary tract as a prerequisite for renal transplantation.
abstract: OBJECTIVE To report a two-stage protocol for children in whom bladder reconstruction was followed by kidney transplantation, as about a quarter of children requiring a kidney transplantation show significant lower urinary tract dysfunction, and consequently their bladder is unsuitable for a kidney transplant. PATIENTS AND METHODS Twelve children (median age 9.5 years, range 4.2-16.8) with end-stage renal disease had a lower urinary tract reconstruction before kidney transplantation. The cause of bladder dysfunction and renal failure included posterior urethral valves in five, neuropathic bladder in two, prune-belly syndrome in two, anal-rectum and urethral atresia syndrome in one, primary obstructive uropathy in one and caudal regression syndrome in one. Two children were diverted with an ileal conduit; four had a bladder augmentation, and four had a bladder augmentation with additional continent cutaneous stoma. A continent urinary reservoir was constructed in one boy, and one boy had a Mitrofanoff-only procedure. Subsequently, 11 children were transplanted. RESULTS The graft survival rate was 11 of 12 at 1 year and eight of 12 at 5 years. No patient lost the graft related to the reconstructed lower urinary tract. During the median (range) follow-up of 5.4 (1.6-12.5) years all but one child had free drainage of the upper urinary tract. All 10 children who did not have an ileal conduit are continent. CONCLUSION Reconstruction of the lower urinary tract followed by renal transplantation is a safe and efficient approach. It has the advantage of restoring the lower urinary tract before immunosuppressive therapy, and supplies the best possible reservoir for a transplanted kidney.
authors.affiliation: Department of Urology and Paediatric Urology, University of Heidelberg, Heidelberg, Germany. Nenad.Djakovic@med.uni-heidelberg.de
authors.forename: Nenad
authors.initials: N
authors.lastname: Djakovic
authors.forename: Nina
authors.initials: N
authors.lastname: Wagener
authors.forename: Judith
authors.initials: J
authors.lastname: Adams
authors.forename: Christian
authors.initials: C
authors.lastname: Gilfrich
authors.forename: Axel
authors.initials: A
authors.lastname: Haferkamp
authors.forename: Jesco
authors.initials: J
authors.lastname: Pfitzenmaier
authors.forename: Burkhard
authors.initials: B
authors.lastname: Toenshoff
authors.forename: Jan
authors.initials: J
authors.lastname: Schmidt
authors.forename: Markus
authors.initials: M
authors.lastname: Hohenfellner
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006085:Graft Survival; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D011183:Postoperative Complications / Q000209:etiology; D016896:Treatment Outcome; D001743:Urinary Bladder / Q000601:surgery*; D014547:Urinary Diversion / Q000379:methods*; D016476:Urinary Reservoirs, Continent; D014551:Urinary Tract / Q000002:abnormalities / Q000601:surgery*