Expression of the osmotically responsive cationic channel TRPV4 in the endolymphatic sac.
The immunohistochemical expression pattern and the physiological role of transient receptor potential vanilloid (TRPV) 4 in the endolymphatic sac were investigated. TRPV4 was expressed predominantly in the apical membrane of mitochondria-rich cells, and cell volume regulation by TRPV4 was observed in a tissue culture of the rat endolymphatic sac. TRPV4 was also present in the endolymphatic sacs of patients with vestibular schwannoma and with Ménière's disease. TRPV4 is assumed to play a role as an osmoreceptor in cell and fluid volume regulation in the human endolymphatic sac.
Kumagami
H
H
Department of Otolaryngology, Nagasaki University, Sakamoto 1-7-1, Nagasaki 852-8501, Japan. kumagami@nagasaki-u.ac.jp
Terakado
M
M
Sainoo
Y
Y
Baba
A
A
Fujiyama
D
D
Fukuda
T
T
Takasaki
K
K
Takahashi
H
H
D000328:Adult; D000818:Animals; D004712:Endolymphatic Sac / Q000502:physiology* / Q000601:surgery; D006706:Homeostasis; D006801:Humans; D007150:Immunohistochemistry; D008575:Meniere Disease / Q000503:physiopathology; D008875:Middle Aged; D051336:Mitochondrial Membranes / Q000502:physiology; D009464:Neuroma, Acoustic / Q000235:genetics* / Q000503:physiopathology; D051381:Rats; D050916:TRPV Cation Channels / Q000235:genetics* / Q000502:physiology
D050916:TRPV Cation Channels; C416986:TRPV4 protein, human; C486577:Trpv4 protein, rat