[Effect of bovine colostrum protein on rat bone mineral density].
OBJECTIVE
To investigate the effect of bovine colostrum protein (BCP) on bone mineral density (BMD) in ovariectomized (ovx) rats.


METHODS
48 female Sprague-Dawley rats of clean grade were ovariectomized and another 12 rats received a sham operation. The ovx rats were randomly separated into 4 groups: ovx control, ovx low-does, ovx media dose, and ovx high-dose. BCP at the doses of 0.20, 1.00 and 2.00 g/(kg bw x d) were applied in rat diet, and the rats were gavaged once per day for 12 weeks. BMD (at proximal, middle of diaphysis, and distal end) was measured by dual energy X-ray absorptiomery, and the body weight, length and weight of thighbone were measured also.


RESULTS
The bone density, bone weight, bone weight/length and bone weight/body weight in all dosages BCP groups were significantly higher than those in ovx groups.


CONCLUSIONS
BCP at the dose of 0.20 g/(kg bw x d) increase femur bone density at proximal and middle segment, and distal end in ovx rat.
Du
Ming
M
College of Food Science & Engineering, Harbin Institute of Technology, Harbin 150090, China. duming121@163.com
Wang
Cong
C
Zhang
Lanwei
L
D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D002417:Cattle; D003126:Colostrum / Q000737:chemistry*; D005260:Female; D005269:Femur / Q000378:metabolism; D008894:Milk Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D010052:Ovariectomy; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D008894:Milk Proteins