Putting a KAP on transcription and stress.
Chromatin regulation plays an important role in brain development and the generation of phenotypic diversity. In this issue of Neuron, Jakobsson et al. find that disruption in neurons of KAP1, a key component of transcriptional repressor complexes in the brain, results in increased anxiety-like behavior and sensitivity to stress.
Alter
Mark D
MD
Department of Psychiatry, Columbia University, New York, NY 10032, USA.
Hen
Rene
R
D000818:Animals; D001921:Brain / Q000378:metabolism; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology*; D012097:Repressor Proteins / Q000235:genetics / Q000502:physiology*; D013315:Stress, Psychological / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D014158:Transcription, Genetic / Q000502:physiology*; D000076183:Tripartite Motif-Containing Protein 28
D009687:Nuclear Proteins; D012097:Repressor Proteins; C103190:Trim28 protein, mouse; D000076183:Tripartite Motif-Containing Protein 28