title: Curative reconstruction of a giant midbasilar trunk aneurysm with the pipeline embolization device.
abstract: OBJECTIVE
  To demonstrate the curative reconstruction of a giant circumferential basilar trunk aneurysm using the Pipeline embolization device (PED) (Chestnut Medical Technologies, Inc., Menlo Park, CA) alone, without embolization coils.
  
  
  METHODS
  A 13-year-old female patient was referred for the treatment of a 4-cm, partially thrombosed, circumferential midbasilar trunk aneurysm. Her presenting symptoms included headache, nystagmus, and left upper-extremity ataxia. Open surgical and conventional endovascular treatment options were thought to be of unacceptably high risk and unlikely to achieve a definitive treatment. The patient underwent PED treatment under a Food and Drug Administration compassionate use exemption.
  
  
  RESULTS
  An endovascular construct was built across the affected segment of the basilar trunk with 7 serially placed, telescoping PEDs, which bridged the 29-mm aneurysm neck. Completion angiography demonstrated considerably decreased flow into the aneurysm, with stasis persisting into the venous phase of angiography. No technical complications were encountered. No new neurological symptoms were evident, and the patient's original presenting symptoms resolved completely within 24 hours after the procedure. She was discharged on postoperative Day 3. Computed tomography performed on postoperative Day 5 demonstrated no change in the size of the collective aneurysm-thrombus mass. Conventional angiography performed on postoperative Day 7 showed anatomic reconstruction of the basilar artery and complete occlusion of the circumferential aneurysm. The patient remains neurologically normal.
  
  
  CONCLUSIONS
  The PED provides a safe and definitive constructive treatment option for large, giant, and fusiform/circumferential aneurysms. The PED can achieve complete aneurysm occlusion without embolization coils. When applied judiciously, the PED may be used safely in vascular segments that give rise to eloquent perforators.
authors.affiliation: Department of Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona 85013, USA. david.fiorella@bnaneuro.net
authors.forename: David
authors.initials: D
authors.lastname: Fiorella
authors.forename: Michael E
authors.initials: ME
authors.lastname: Kelly
authors.forename: Felipe C
authors.initials: FC
authors.lastname: Albuquerque
authors.forename: Peter K
authors.initials: PK
authors.lastname: Nelson
mesh_terms: D000293:Adolescent; D001807:Blood Vessel Prosthesis; D004621:Embolization, Therapeutic / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D002532:Intracranial Aneurysm / Q000628:therapy*; D008297:Male; D019919:Prosthesis Implantation / Q000379:methods*; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures / Q000295:instrumentation* / Q000379:methods