title: Circulating T cells derived from acute leukemia patients with severe therapy-induced cytopenia express a wide range of chemokine receptors.
abstract: Normal T cells can mediate antileukemic reactivity after allogeneic stem cell transplantation and T cell targeting immunotherapy is now considered for patients receiving conventional chemotherapy. This antileukemic reactivity is most effective in patients with a low leukemia cell burden, and this burden is expected to be lowest early after transplantation/chemotherapy when patients are cytopenic. Local T cell recruitment will then be essential for the efficiency of the antileukemic response. In this context, the authors compared the chemokine receptor expression for T cells derived from healthy individuals and acute myelogenous leukemia patients with therapy-induced cytopenia after conventional chemotherapy or allogeneic stem cell transplantation. Circulating CD3(+) T cells showed the same chemokine receptor expression for all three groups: CCR1(low), CCR2(low), CCR3(low), CCR4(intermediate), CCR5(intermediate), CCR7(low/intermediate), CXCR2(low), CXCR3(intermediate), and CXCR4(high). Thus, only minor differences between the groups were observed when comparing individual receptors, and we therefore conclude that the chemokine receptor profiles of circulating CD3(+) T cells show no qualitative and only minor quantitative differences for these three groups.
authors.affiliation: Division for Hematology, Department of Medicine, Haukeland University Hospital and The University of Bergen, Bergen, Norway.
authors.forename: Astrid Marta
authors.initials: AM
authors.lastname: Olsnes
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Ersvaer
authors.forename: Anita
authors.initials: A
authors.lastname: Ryningen
authors.forename: Oystein
authors.initials: O
authors.lastname: Bruserud
mesh_terms: D000328:Adult; D000368:Aged; D017252:CD3 Complex; D016022:Case-Control Studies; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000276:immunology / Q000628:therapy; D008875:Middle Aged; D010198:Pancytopenia / Q000139:chemically induced*; D019707:Receptors, Chemokine / Q000032:analysis*; D013601:T-Lymphocytes / Q000737:chemistry / Q000276:immunology*; D014184:Transplantation, Homologous
chemical_list: D017252:CD3 Complex; D019707:Receptors, Chemokine