Taste, olfactory and trigeminal neophobia in rats with forebrain lesions.
The present study was designed to examine whether lesions of the insular cortex (IC; Experiment 1), the basolateral amygdala (BLA) or medial amygdala (MeA; Experiment 2) influence the neophobic reactions to orally consumed liquid stimuli. Three different types of stimuli were used: taste (0.5% saccharin), olfactory (0.1% amyl acetate), and trigeminal (0.01 mM capsaicin). Rats with IC, BLA and MeA lesions showed normal responses to the olfactory and trigeminal stimuli. Each type of lesion, however, disrupted the initial occurrence of neophobia to the taste stimulus. The significance of these findings to conditioned taste aversion is discussed.
Lin
Jian-You
JY
Department of Psychology, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607, USA.
Roman
Christopher
C
St Andre
Justin
J
Reilly
Steve
S
D000679:Amygdala / Q000033:anatomy & histology / Q000502:physiology; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D002211:Capsaicin / Q000494:pharmacology; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000502:physiology; D003714:Denervation; D004195:Disease Models, Animal; D008297:Male; D009483:Neuropsychological Tests; D010146:Pain / Q000503:physiopathology* / Q000523:psychology; D000439:Pentanols / Q000494:pharmacology; D010698:Phobic Disorders / Q000209:etiology / Q000503:physiopathology* / Q000523:psychology; D010812:Physical Stimulation; D016548:Prosencephalon / Q000033:anatomy & histology / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012439:Saccharin / Q000494:pharmacology; D012903:Smell / Q000502:physiology*; D013649:Taste / Q000502:physiology*
D000439:Pentanols; C005716:amyl acetate; D012439:Saccharin; D002211:Capsaicin