title: Heritabilities and quantitative trait loci for blood gases and blood pH in swine.
abstract: Maintaining pH and blood gases in a narrow range is essential to sustain normal biochemical reactions. Decreased oxygenation, poor tissue perfusion, disturbance to CO(2) expiration, and shortage of HCO(3)(-) can lead to metabolic acidosis. This is a common situation in swine, and originates from a broad range of medical conditions. pH and blood gases appear to be under genetic control, and populations with physiological traits closer to the pathological thresholds may be more susceptible to developing pathological conditions. However, little is known about the genetic basis of such traits. We have therefore estimated phenotypic and genetic variability and identified quantitative trait loci (QTL) for pH and blood gases in blood samples from 139 F(2) pigs from the Meishan/Pietrain family. Samples were taken before and after challenge with Sarcocystis miescheriana, a protozoan parasite of muscle. Twenty-seven QTL influencing pH and blood gases were identified on nine chromosomes. Five of the QTL were significant on a genome-wide level; 22 QTL were significant on a chromosome-wide level. QTL for pH-associated traits have been mapped to SSC3, 18 and X. QTL associated with CO(2) have been detected on SSC6, 7, 8 and 9, and QTL associated with O(2) on SSC2 and SSC8. QTL showed specific health/disease patterns that were related to the physiological state of the pigs from day 0, to acute disease (day 14), convalescence (day 28) and chronic disease (day 42). The results demonstrate that pH and blood gases are influenced by multiple chromosomal areas, each with relatively small effects.
authors.affiliation: Department of Veterinary Clinical Sciences, University of Giessen, D-35392 Giessen, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Reiner
authors.forename: R
authors.initials: R
authors.lastname: Fischer
authors.forename: F
authors.initials: F
authors.lastname: Köhler
authors.forename: T
authors.initials: T
authors.lastname: Berge
authors.forename: S
authors.initials: S
authors.lastname: Hepp
authors.forename: H
authors.initials: H
authors.lastname: Willems
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D002874:Chromosome Mapping; D005260:Female; D005740:Gases / Q000097:blood*; D006863:Hydrogen-Ion Concentration; D008297:Male; D010100:Oxygen / Q000097:blood; D040641:Quantitative Trait Loci; D019655:Quantitative Trait, Heritable; D012522:Sarcocystis / Q000472:pathogenicity; D012523:Sarcocystosis / Q000097:blood / Q000235:genetics / Q000662:veterinary; D034421:Sus scrofa / Q000097:blood* / Q000235:genetics*; D013553:Swine Diseases / Q000097:blood / Q000235:genetics
chemical_list: D005740:Gases; D002245:Carbon Dioxide; D010100:Oxygen