Adrenal insufficiency associated with cytomegalovirus infection in two infants.
Adrenal insufficiency associated with cytomegalovirus (CMV) is a well-described condition in adults with AIDS, however there is little information about CMV-associated adrenal insufficiency in childhood. The cases of two infants with negative HIV serology, presenting with CMV-associated adrenal insufficiency, are described. Clinical findings and therapeutic interventions are discussed with reference to the affinity of CMV infection for the adrenal gland. The differential diagnosis of adrenal insufficiency in newborns and infants should include CMV infection, and clinical suspicion of CMV-associated adrenal insufficiency should lead to early initiation of appropriate adrenal substitution therapy and ganciclovir antiviral therapy. Timely therapy for CMV-associated adrenal insufficiency can be lifesaving.
Dinleyici
Ener Cagri
EC
Department of Pediatrics, Pediatric Endocrinology and Microbiology, Faculty of Medicine, Eskisehir Osmangazi University, TR-26480 Eskisehir, Turkey. timboothtr@yahoo.com
Dogruel
Nesrin
N
Dinleyici
Meltem
M
Us
Tercan
T
D000309:Adrenal Insufficiency / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D016176:T-Lymphocyte Subsets / Q000276:immunology; D016896:Treatment Outcome
D000998:Antiviral Agents