Statistical evaluation of the in vivo micronucleus assay.
The statistical evaluation of the in vivo micronucleus assay is focused on multiple contrast tests for comparisons versus the negative control for count data taking the between-animals variability into account. For a possible claim the compound is not genotoxic in the micronucleus assay a proof of safety approach is proposed. For these statistical approaches user-friendly software is free available.
Hothorn
Ludwig A
LA
Institute of Biostatistics, Leibniz University, Herrenhauser Str. 2, 30419 Hannover, Germany. hothorn@biostat.uni-hannover.de
Gerhard
Daniel
D
D000818:Animals; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D005260:Female; D008297:Male; D051379:Mice; D015162:Micronucleus Tests / Q000379:methods; D015233:Models, Statistical; D009153:Mutagens / Q000633:toxicity*; D012984:Software
D009153:Mutagens