title: Multi-modal 19F NMR probe using perfluorinated cubic silsesquioxane-coated silica nanoparticles for monitoring enzymatic activity.
abstract: The establishment of (19)F NMR signal regulation and the application of this strategy to develop a multi-modal (19)F NMR probe for monitoring enzymatic activity using nanoparticles as a signal regulator is described; water-soluble perfluorinated cubic silsesquioxane was synthesized and immobilized onto the silica nanoparticles for suppressing the signals; (19)F NMR signals of the probes were recovered by releasing from nanoparticles.
authors.affiliation: Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tanaka
authors.forename: Narufumi
authors.initials: N
authors.lastname: Kitamura
authors.forename: Kensuke
authors.initials: K
authors.lastname: Naka
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Chujo
mesh_terms: D000469:Alkaline Phosphatase / Q000032:analysis* / Q000378:metabolism; D017611:Fluorine Compounds / Q000737:chemistry*; D005462:Fluorine Radioisotopes; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D053758:Nanoparticles / Q000032:analysis* / Q000737:chemistry*; D017646:Organosilicon Compounds / Q000737:chemistry*; D012822:Silicon Dioxide / Q000032:analysis* / Q000737:chemistry*
chemical_list: D017611:Fluorine Compounds; D005462:Fluorine Radioisotopes; D017646:Organosilicon Compounds; D012822:Silicon Dioxide; D000469:Alkaline Phosphatase