Host factors do not influence the colonization or infection by fluconazole resistant Candida species in hospitalized patients.
Nosocomial yeast infections have significantly increased during the past two decades in industrialized countries, including Taiwan. This has been associated with the emergence of resistance to fluconazole and other antifungal drugs. The medical records of 88 patients, colonized or infected with Candida species, from nine of the 22 hospitals that provided clinical isolates to the Taiwan Surveillance of Antimicrobial Resistance of Yeasts (TSARY) program in 1999 were reviewed. A total of 35 patients contributed fluconazole resistant strains [minimum inhibitory concentrations (MICs) > or = 64 mg/l], while the remaining 53 patients contributed susceptible ones (MICs < or = 8 mg/l). Fluconazole resistance was more frequent among isolates of Candida tropicalis (46.5%) than either C. albicans (36.8%) or C. glabrata (30.8%). There was no significant difference in demographic characteristics or underlying diseases among patients contributing strains different in drug susceptibility.
Yang
Yun-Liang
YL
Division of Clinical Research, National Health Research Institutes, Miaoli, Taiwan, Republic of China. yyang@mail.nctu.edu.tw
Cheng
Ming-Fang
MF
Chang
Ya-Wen
YW
Young
Tzuu-Guang
TG
Chi
Hsin
H
Lee
Sai Cheong
SC
Cheung
Bruno Man-Hon
BM
Tseng
Fan-Chen
FC
Chen
Tun-Chieh
TC
Ho
Yu-Huai
YH
Shi
Zhi-Yuan
ZY
Chan
Chung-Huang Hubert
CH
Lin
Ju-Yu
JY
Lo
Hsiu-Jung
HJ
D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002175:Candida / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification*; D002177:Candidiasis / Q000188:drug therapy / Q000382:microbiology*; D025141:Drug Resistance, Fungal; D015725:Fluconazole / Q000494:pharmacology* / Q000627:therapeutic use; D006760:Hospitalization; D006801:Humans; D013624:Taiwan / Q000453:epidemiology
D000935:Antifungal Agents; D015725:Fluconazole