[Diagnosis of Helicobacter pylori infection: comparison with gold standard].
Marshall and Warren were the first to succeed in culturing Helicobacter pylori (H. pylori) from the gastric mucosa of patients with gastritis in 1983. H. pylori is a spiral-shaped bacterium that resides in the gastric mucosa and is one of the most common infections worldwide. H. pylori infection causes gastritis and peptic ulcers and is associated with the development of gastric cancer and MALT lymphoma. Now, a variety of accurate diagnostic tests are widely available. Both invasive tests (bacterial culture, histopathology, and RUT) and non-invasive tests (UBT and serological test) are conducted for the diagnosis of H. pylori infection. This review provides a general overview of the diagnostic methods and tests the characteristics (sensitivity and specificity) for H. pylori infection.
Koido
Shigeo
S
Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Kashiwa Hospital, Kashiwa 277-8567, Japan. shigeo_koido@jikei.ac.jp
Odahara
Shunichi
S
Mitsunaga
Makoto
M
Aizawa
Mashu
M
Itoh
Shuji
S
Uchiyama
Kan
K
Komita
Hideo
H
Satoh
Kenichi
K
Kuniyasu
Yuhshi
Y
Yamane
Tateki
T
Ohkusa
Toshifumi
T
D000907:Antibodies, Bacterial / Q000032:analysis; D000942:Antigens, Bacterial / Q000032:analysis; D001431:Bacteriological Techniques; D001944:Breath Tests; D003124:Colorimetry; D005753:Gastric Mucosa / Q000382:microbiology; D016481:Helicobacter Infections / Q000175:diagnosis*; D016480:Helicobacter pylori / Q000276:immunology / Q000302:isolation & purification / Q000648:ultrastructure; D006801:Humans; D008853:Microscopy; D012680:Sensitivity and Specificity; D012698:Serologic Tests / Q000379:methods; D014508:Urea; D014510:Urease
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D014508:Urea; D014510:Urease