Disulfide-cross-linked PEG-poly(amino acid)s copolymer micelles for glutathione-mediated intracellular drug delivery.
We report biocompatible, cell-permeable core-shell-corona polymer micelles bearing glutathione-cleavable shell cross-links, which allow the facilitated release of entrapped anticancer drugs at cytoplasm in response to an intracellular glutathione level.
Koo
Ahn Na
AN
Nanomaterials Application Division, Korea Institute of Ceramic Engineering and Technology, Seoul, 153-801, Korea.
Lee
Hong Jae
HJ
Kim
Sung Eun
SE
Chang
Jeong Ho
JH
Park
Chiyoung
C
Kim
Chulhee
C
Park
Jae Hyung
JH
Lee
Sang Cheon
SC
D000596:Amino Acids / Q000737:chemistry*; D004220:Disulfides / Q000737:chemistry*; D016503:Drug Delivery Systems; D005978:Glutathione / Q000737:chemistry*; D008823:Micelles; D011092:Polyethylene Glycols / Q000737:chemistry*
D000596:Amino Acids; D004220:Disulfides; D008823:Micelles; D011092:Polyethylene Glycols; D005978:Glutathione