title: Lysophospholipid receptors in vertebrate development, physiology, and pathology.
abstract: Lysophospholipid (LP) research has experienced a period of renaissance with the discovery of the lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) receptors in the late 1990s. Vertebrate LP receptors regulate embryogenesis, vascular development, neurogenesis, uterine development, oocyte survival, immune cell trafficking and inflammatory reactions. LP signaling is important in cancer, autoimmunity and inflammatory diseases. Research on LP biology has contributed to the development of a first-generation S1P receptor modulator that has entered phase III clinical trials for the treatment of multiple sclerosis. Further basic research on LP signaling is anticipated to lead to novel therapeutic tools to combat various human diseases.
authors.affiliation: Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030, USA.
authors.forename: Athanasia
authors.initials: A
authors.lastname: Skoura
authors.forename: Timothy
authors.initials: T
authors.lastname: Hla
mesh_terms: D000818:Animals; D002319:Cardiovascular System / Q000378:metabolism; D004194:Disease; D006801:Humans; D009420:Nervous System / Q000378:metabolism; D049312:Receptors, Lysophospholipid / Q000276:immunology / Q000378:metabolism*; D012098:Reproduction; D014714:Vertebrates / Q000276:immunology / Q000378:metabolism*
chemical_list: D049312:Receptors, Lysophospholipid