title: Working memory dysfunction in obsessive-compulsive disorder: a neuropsychological and functional MRI study.
abstract: Previous neuropsychological studies indicate that OCD subtypes such as checking rituals might be associated with a working memory deficit. On the other hand, functional neuroimaging studies found functional abnormalities of the frontal cortex and subcortical structures in OCD. Combined with functional imaging method, we applied neuropsychological batteries to demonstrate a working memory deficit in OCD by comparison with normal controls. In addition, working memory and brain activation were further examined with symptom-based analysis. Forty patients with OCD and 25 normal controls were examined using neuropsychological tests including the WAIS-R, WCST, WMS-R, and R-OCFT and functional MRI (fMRI) during the N-back task including 0- and 2-back task. On fMRI, the brain regions activated during the performance and the differences in the activation between patients and controls were identified. Additional analyses of severity and subtypes were conducted by using Y-BOCS severity score, symptom-checklist and Leckman's four-factor model, respectively. On the neuropsychological tests, the OCD patients had significantly lower scores on the delayed recall section of the WMS-R and the immediate recall section of the R-OCFT compared to the controls. On fMRI, the patients showed greater activation in the right dorsolateral prefrontal cortex (DLPFC), left superior temporal gyrus (STG), left insula, and cuneus during two-back task compared to the controls. Right orbitofrontal cortex activity showed a significant positive correlation with Y-BOCS scores in OCD. Furthermore, patients with obsessions/checking rituals (n=10) showed severer memory deficits and decreased activity in the postcentral gyrus than patients with cleanliness/washing rituals (n=14). In conclusion, we found neuropsychological dysfunction and brain abnormalities in OCD. Furthermore, our results suggested that symptom severity and symptom subtype such as obsessions/checking might affect neuropsychological dysfunction and related brain activities.
authors.affiliation: Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan. tomona@npsych.med.kyushu-u.ac.jp
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Nakao
authors.forename: Akiko
authors.initials: A
authors.lastname: Nakagawa
authors.forename: Eriko
authors.initials: E
authors.lastname: Nakatani
authors.forename: Maiko
authors.initials: M
authors.lastname: Nabeyama
authors.forename: Hirokuni
authors.initials: H
authors.lastname: Sanematsu
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshiura
authors.forename: Osamu
authors.initials: O
authors.lastname: Togao
authors.forename: Mayumi
authors.initials: M
authors.lastname: Tomita
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Masuda
authors.forename: Kazuko
authors.initials: K
authors.lastname: Yoshioka
authors.forename: Toshihide
authors.initials: T
authors.lastname: Kuroki
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Kanba
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000503:physiopathology*; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000503:physiopathology; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology*; D017397:Prefrontal Cortex / Q000503:physiopathology; D011569:Psychiatric Status Rating Scales; D011597:Psychomotor Performance; D012720:Severity of Illness Index; D013702:Temporal Lobe / Q000503:physiopathology; D055815:Young Adult