The polymorphisms on Igkappa gene are related to susceptibility of breast cancer and gastric cancer.
The phenomenon of immunoglobulin (Ig) expression in cancer cells has been discovered recently; the Ig protein expressed and secreted in cancer cells was found to be in favor of tumor growth. Two single-nucleotide polymorphism (SNP) loci rs232230 (5658C/G) and rs232228 (3635T/C) were identified on Igkappa gene previously, and we have demonstrated that they were associated with nasopharyngeal carcinoma susceptibility. In the present study, we further performed the study focused on these two SNPs in gastric and breast cancer, trying to demonstrate the association between the genotypes of the two SNPs and the susceptibility of gastric cancer and breast cancer. Our results suggested that the 5658-G allele and 3635-C allele were risk factors for both gastric cancer (odds ratio [OR]: 1.64 and 1.67, respectively) and breast cancer (OR: 1.94 and 1.56, respectively). Further, we also identified that they were related to other risk factors, including Helicobacter pylori (Hp) infection in gastric cancer and age in breast cancer.
Hu
Duosha
D
Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha City, China.
Tong
Sun
S
Wei
Ren
R
Hui
Zheng
Z
Haidan
Liu
L
Zhi
Duan
D
Lili
Li
L
Wen
Tan
T
Dan
Zhao
Z
Yanfeng
Liu
L
Dongxin
Lin
L
Ya
Cao
C
D000328:Adult; D000367:Age Factors; D000368:Aged; D001483:Base Sequence; D001943:Breast Neoplasms / Q000209:etiology / Q000235:genetics* / Q000276:immunology*; D016022:Case-Control Studies; D017931:DNA Primers / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D016481:Helicobacter Infections / Q000150:complications; D016480:Helicobacter pylori; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000209:etiology / Q000235:genetics* / Q000276:immunology*
D017931:DNA Primers; D004273:DNA, Neoplasm; D007145:Immunoglobulin kappa-Chains; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone