title: Effects of strain rate, mixing ratio, and stress-strain definition on the mechanical behavior of the polydimethylsiloxane (PDMS) material as related to its biological applications.
abstract: Tensile tests on Polydimethylsiloxane (PDMS) materials were conducted to illustrate the effects of mixing ratio, definition of the stress-strain curve, and the strain rate on the elastic modulus and stress-strain curve. PDMS specimens were prepared according to the ASTM standards for elastic materials. Our results indicate that the physiological elastic modulus depends strongly on the definition of the stress-strain curve, mixing ratio, and the strain rate. For various mixing ratios and strain rates, true stress-strain definition results in higher stress and elastic modulus compared with engineering stress-strain and true stress-engineering strain definitions. The elastic modulus increases as the mixing ratio increases up-to 9:1 ratio after which the elastic modulus begins to decrease even as the mixing ratio continues to increase. The results presented in this study will be helpful to assist the design of in vitro experiments to mimic blood flow in arteries and to understand the complex interaction between blood flow and the walls of arteries using PDMS elastomer.
authors.affiliation: Vascular Mechanics Laboratory, Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA. khanafer@umich.edu
authors.forename: Khalil
authors.initials: K
authors.lastname: Khanafer
authors.forename: Ambroise
authors.initials: A
authors.lastname: Duprey
authors.forename: Marty
authors.initials: M
authors.lastname: Schlicht
authors.forename: Ramon
authors.initials: R
authors.lastname: Berguer
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D003198:Computer Simulation; D004129:Dimethylpolysiloxanes / Q000737:chemistry*; D055119:Elastic Modulus; D008956:Models, Chemical; D013314:Stress, Mechanical; D013718:Tensile Strength
chemical_list: D001672:Biocompatible Materials; D004129:Dimethylpolysiloxanes; C013830:baysilon