title: Kinetochore attachment: how the hec can a cell do it?
abstract: Creating stable yet flexible attachments of spindle microtubules to the kinetochore is critical for facilitating chromosome congression, segregation, and checkpoint signaling. Two new studies have elucidated the molecular details of how the Ndc80 complex mediates this dynamic attachment.
authors.affiliation: Biochemistry Program and Medical Sciences, Indiana University, 915 E. 3rd Street, Myers Hall 262, Bloomington, IN 47405, USA.
authors.forename: Shang
authors.initials: S
authors.lastname: Cai
authors.forename: Claire E
authors.initials: CE
authors.lastname: Walczak
mesh_terms: D020090:Chromosome Segregation; D003598:Cytoskeletal Proteins; D005786:Gene Expression Regulation; D006801:Humans; D018386:Kinetochores / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism*; D008938:Mitosis; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D008941:Spindle Apparatus / Q000378:metabolism; D014404:Tubulin / Q000235:genetics / Q000378:metabolism*
chemical_list: D003598:Cytoskeletal Proteins; C120529:NDC80 protein, human; D009687:Nuclear Proteins; D014404:Tubulin