Peripheral nerve: what's new in basic science laboratories.
Peripheral nerve regeneration research has unfolded a wealth of basic science knowledge in the last century. Today, that knowledge has become the fundamental groundwork for evolving clinical applications to treat peripheral nerve defects. This article discusses two clinical applications that have been investigated thoroughly in the laboratory setting for decades and recently tested in the clinical setting: nerve allotransplantation to graft nerve defects, and brief electrical stimulation to promote nerve regeneration. It also discusses the generation of Thy-1-XFP transgenic mice, which express fluorescent proteins in the nervous system and provide new avenues for investigating peripheral nerve regeneration.
Song
Jae W
JW
Department of Neurosurgery, New York University School of Medicine, New York, NY 10016, USA.
Yang
Lynda J
LJ
Russell
Stephen M
SM
D000818:Animals; D004195:Disease Models, Animal; D004599:Electric Stimulation Therapy / Q000379:methods / Q000639:trends; D049452:Green Fluorescent Proteins / Q000235:genetics; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D009416:Nerve Regeneration / Q000502:physiology; D016067:Nerve Transfer / Q000379:methods / Q000639:trends; D010525:Peripheral Nerves / Q000503:physiopathology / Q000601:surgery* / Q000637:transplantation; D010523:Peripheral Nervous System Diseases / Q000503:physiopathology / Q000628:therapy*; D014184:Transplantation, Homologous / Q000379:methods / Q000639:trends
D049452:Green Fluorescent Proteins