Down-regulation of allergic responses in conditions of experimental diabetes: a role for glucocorticoids?
The prevalence of atopic diseases and diabetes is increasing worldwide, though the co-occurrence of both diseases in the same individual is less frequent than predicted. Previously published studies suggest that the Th1/Th2 concept could explain the inverse relationship between allergic diseases and type 1 diabetes. However, down-regulation of the IgE-mast cell system can also markedly contribute to the lack of responsiveness to local and systemic allergen challenges in diabetic conditions. Moreover, dysregulation of the hypothalamic-pituitary-adrenocortical axis and elevated endogenous glucocorticoid levels play a pertinent role in some of the pathological-related processes associated with poorly controlled or uncontrolled diabetes.
e Silva
Patrícia M R
PM
Laboratório de Inflamação, Departamento de Fisiologia e Farmacodinâmica, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brasil. patmar@ioc.fiocruz.br
Carvalho
Vinicius F
VF
Cordeiro
Renato S B
RS
Martins
Marco A
MA
D000818:Animals; D048909:Diabetes Complications / Q000276:immunology* / Q000503:physiopathology*; D015536:Down-Regulation / Q000276:immunology; D005938:Glucocorticoids / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology* / Q000503:physiopathology*; D007108:Immune Tolerance / Q000276:immunology*; D007073:Immunoglobulin E / Q000276:immunology; D008407:Mast Cells / Q000276:immunology; D015213:Neuroimmunomodulation / Q000276:immunology; D010913:Pituitary-Adrenal System / Q000276:immunology / Q000503:physiopathology
D005938:Glucocorticoids; D007073:Immunoglobulin E