title: Modeling the eye's optical system by ocular wavefront tomography.
abstract: OBJECTIVE
  Ocular wavefront tomography (OWT) is the process of using wavefront aberration maps obtained along multiple lines-of-sight (LoS) to determine the shape and position of the major refracting elements of an eye. One goal of OWT is to create a customized schematic model eye that is anatomically similar and functionally equivalent to the individual eye over a large field of view.
  
  
  METHODS
  Wavefront aberration maps along multiple LoS were used as design goals for configuring a generic, multi-surface model eye with aberrations that match the measurements. The model was constrained by gross anatomical dimensions and optimized to mimic the measured eye. The method was evaluated with two test cases: (1) a physical model eye with a doublet lens measured with a clinical wavefront aberrometer along six LoS between -31 deg and +29 deg eccentricities, and (2) a mathematical model of the myopic eye for which wavefront aberrations were computed by ray tracing.
  
  
  RESULTS
  In case 1, the OWT algorithm successfully predicted the structure of the doublet model eye from the experimental on- and off-axis aberration measurements. In case 2, the algorithm started with a symmetric five surface model eye and optimized it to generate the on- and off-axis aberrations of a GRIN myopia model eye. The adjusted model closely mimicked the physical parameters and optical behavior of the expected myopia model eye over a large field of view. The maximum discrepancy between aberrations of the OWT optimized model and measurements was 0.05 microns RMS for test case 1 and 0.2 microns RMS for test case 2.
  
  
  CONCLUSIONS
  Our implementation of OWT is a valid, feasible, and robust method for constructing an optical model that is anatomically and functionally similar to the eye over a wide field of view.
authors.affiliation: School of Optometry, Indiana University, 800 East Atwater Ave., Bloomington, IN 47405, USA. weix@indiana.edu
authors.forename: Xin
authors.initials: X
authors.lastname: Wei
authors.forename: Larry
authors.initials: L
authors.lastname: Thibos
mesh_terms: D003198:Computer Simulation; D003315:Cornea / Q000503:physiopathology*; D019781:Corneal Topography / Q000379:methods*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008954:Models, Biological; D012030:Refractive Errors / Q000503:physiopathology*; D041622:Tomography, Optical / Q000379:methods*