title: Antitumour polyether macrolides: four new halichondrins from the New Zealand deep-water marine sponge Lissodendoryx sp.
abstract: The isolation is reported of four new variants of the halichondrin B skeleton, very minor potently bioactive components from the Poecilosclerid sponge Lissodendoryx sp. These compounds were isolated in microgram quantities only from a collection of 1tonne of sponge. The structural elucidations relied heavily on the use of capillary NMR spectroscopy and the application of an HSQC-DEPT overlay technique.
authors.affiliation: Department of Chemistry, University of Canterbury, Private Bag 4800, Christchurch, New Zealand.
authors.forename: Sarah J H
authors.initials: SJ
authors.lastname: Hickford
authors.forename: John W
authors.initials: JW
authors.lastname: Blunt
authors.forename: Murray H G
authors.initials: MH
authors.lastname: Munro
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002853:Chromatography, Liquid; D004354:Drug Screening Assays, Antitumor; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008386:Marine Biology; D013058:Mass Spectrometry; D011161:Porifera; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000970:Antineoplastic Agents; D018942:Macrolides