Botulinum toxin for pelvic pain in women.
Pelvic pain is a common disorder in women, causing significant morbidity. Often the etiology is not clear as it results from a complex interaction between neurologic, musculoskeletal and endocrine systems that is further influenced by behavioral and psychological factors. A comprehensive approach to the problem requires recognition of the multiple organ systems that may be involved. A thorough history and physical examination, followed by selected laboratory and imaging studies, is essential in evaluation of these patients. Medical and surgical management improves or controls the symptoms in the majority of cases, but there remains a group of women who are difficult to treat. Botulinum toxin is a presynaptic neuromuscular blocking agent inducing selective and reversible muscle weakness that lasts several months when injected intramuscularly. It has been shown to be effective in treating pain caused by muscular spasm in conditions other than pelvic pain caused by muscular hypertonicity. Evidence or literature related to treatment of pelvic pain with botulinum toxin is discussed in this review.
Sinha
Deepali
D
Worcestershire Royal Hospital, Charles Hastings Way, Worcester WR51DD, UK. adsinha@hotmail.com
Thomson
Angus J
AJ
D019274:Botulinum Toxins, Type A / Q000494:pharmacology*; D002908:Chronic Disease; D018856:Cystitis, Interstitial / Q000150:complications / Q000188:drug therapy; D005260:Female; D005767:Gastrointestinal Diseases / Q000150:complications / Q000188:drug therapy; D006801:Humans; D009465:Neuromuscular Agents / Q000494:pharmacology*; D017699:Pelvic Pain / Q000188:drug therapy* / Q000209:etiology; D016032:Randomized Controlled Trials as Topic
D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A