[Association of single nucleotide polymorphism rs599839 on chromosome 1p13.3 with premature coronary heart disease in a Chinese Han population].
OBJECTIVE
To investigate the association of single nucleotide polymorphism (SNP) rs599839 on chromosome 1p13.3 with premature coronary heart disease.


METHODS
A case-control association study of 303 unrelated premature coronary heart disease patients and 312 normal controls from a Chinese Han population was performed. Genotype was determined by polymerase chain reaction-restriction fragment length polymorphism for SNP rs599839 on Chromosome 1p13.3.


RESULTS
The frequencies of the G allele were 5.0% and 9.1% in the premature coronary heart disease group and control group respectively (P= 0.004). The presence of the G allele was associated with significantly lower concentration of the low density lipoprotein-cholesterol (LDL-C) in both groups.


CONCLUSIONS
The present findings suggest that the genetic polymorphism in rs599839 may be associated with the development of premature coronary heart disease in Chinese Han population, and the polymorphism may have some influence on serum LDL-C level in this population.
Huang
Hao
H
Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China.
Pan
Lingai
L
Zhang
Li
L
Chen
Yucheng
Y
Zeng
Zhi
Z
D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D003327:Coronary Disease / Q000097:blood / Q000235:genetics* / Q000473:pathology; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
D008055:Lipids