title: Hypersensitivity to clavulanic acid in children.
abstract: We present 10 cases (6 males and 4 females) of children aged 4 to 12 years, who were diagnosed with allergy to clavulanic acid (CL) and treated in the Paediatric Allergy Section of the University Hospital Dr. Peset in Valencia from 2000 to 2005. The children reported symptoms of urticaria and angio-oedema after receiving orally-administered amoxicillin/clavulanic acid (A-CL) for an infection. Diagnosis was based on the confirmation of an IgE-mediated aetiology by an oral challenge test with amoxicillin-clavulanic acid. Following negative skin test results and CAP for penicilloyl G and V, amoxicillin, ampicillin and cefaclor < 0.35 KU/l, those patients who were allergic to clavulanic acid (positive oral challenge test) were shown to be tolerant to orally-administered Cefuroxime axetil.
authors.affiliation: Paediatric Allergy Section. Department of Paediatrics. University of Valencia. Spain. tortajadamig@gmail.com
authors.forename: M
authors.initials: M
authors.lastname: Tortajada Girbés
authors.forename: A
authors.initials: A
authors.lastname: Ferrer Franco
authors.forename: M
authors.initials: M
authors.lastname: Gracia Antequera
authors.forename: A
authors.initials: A
authors.lastname: Clement Paredes
authors.forename: E
authors.initials: E
authors.lastname: García Muñoz
authors.forename: M
authors.initials: M
authors.lastname: Tallón Guerola
mesh_terms: D000284:Administration, Oral; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D019818:Clavulanic Acid / Q000009:adverse effects* / Q000276:immunology; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000276:immunology; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D012189:Retrospective Studies; D012882:Skin Tests
chemical_list: D000900:Anti-Bacterial Agents; D019818:Clavulanic Acid; D007073:Immunoglobulin E