title: A snapshot of CNVs in the pig genome.
abstract: Recent studies of mammalian genomes have uncovered the extent of copy number variation (CNV) that contributes to phenotypic diversity, including health and disease status. Here we report a first account of CNVs in the pig genome covering part of the chromosomes 4, 7, 14, and 17 already sequenced and assembled. A custom tiling oligonucleotide array was used with a median probe spacing of 409 bp for screening 12 unrelated Duroc boars that are founders of a large family material. After a strict CNV calling pipeline, 37 copy number variable regions (CNVRs) across all four chromosomes were identified, with five CNVRs overlapping segmental duplications, three overlapping pig unigenes and one overlapping a RefSeq pig mRNA. This CNV snapshot analysis is the first of its kind in the porcine genome and constitutes the basis for a better understanding of porcine phenotypes and genotypes with the prospect of identifying important economic traits.
authors.affiliation: Group of Molecular Genetics and Systems Biology, Department of Genetics and Biotechnology, Faculty of Agricultural Sciences, Aarhus University, Tjele, Denmark.
authors.forename: João
authors.initials: J
authors.lastname: Fadista
authors.forename: Marianne
authors.initials: M
authors.lastname: Nygaard
authors.forename: Lars-Erik
authors.initials: LE
authors.lastname: Holm
authors.forename: Bo
authors.initials: B
authors.lastname: Thomsen
authors.forename: Christian
authors.initials: C
authors.lastname: Bendixen
mesh_terms: D000818:Animals; D055028:Comparative Genomic Hybridization; D018628:Gene Dosage; D016678:Genome / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D015203:Reproducibility of Results; D020133:Reverse Transcriptase Polymerase Chain Reaction; D034421:Sus scrofa / Q000235:genetics*