Apoptotic signaling pathways as a target for the treatment of liver diseases.
Dysregulation of apoptosis is a major contributor to the initiation and aggravation of liver injury. Agents that modulate apoptosis may be of therapeutic benefit in a number of liver diseases, and research related to cell type-specific activation or inhibition of apoptotic signaling pathways will provide new strategies for treatment.
Mauriz
J L
JL
Institute of Biomedicine, University of León, 24071 León, Spain. jgonga@unileon.es
Tuñón
M J
MJ
González-Gallego
J
J
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D000069059:Atorvastatin; D005912:Gliotoxin / Q000494:pharmacology; D006538:Heptanoic Acids / Q000494:pharmacology; D006801:Humans; D008107:Liver Diseases / Q000188:drug therapy* / Q000473:pathology* / Q000503:physiopathology / Q000821:virology; D008968:Molecular Conformation; D011758:Pyrroles / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects*; D014580:Ursodeoxycholic Acid / Q000737:chemistry / Q000494:pharmacology
D006538:Heptanoic Acids; D011758:Pyrroles; D005912:Gliotoxin; D014580:Ursodeoxycholic Acid; D000069059:Atorvastatin