Targeted Paclitaxel by conjugation to iron oxide and gold nanoparticles.
The Fe(3)O(4) nanoparticles, tailored with maleimidyl 3-succinimidopropionate ligands, were conjugated with paclitaxel molecules that were attached with a poly(ethylene glycol) (PEG) spacer through a phosphodiester moiety at the (C-2')-OH position. The average number of paclitaxel molecules/nanoparticles was determined as 83. These nanoparticles liberated paclitaxel molecules upon exposure to phosphodiesterase.
Hwu
Jih Ru
JR
Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan 300, ROC.
Lin
Yu Sern
YS
Josephrajan
Thainashmuthu
T
Hsu
Ming-Hua
MH
Cheng
Fong-Yu
FY
Yeh
Chen-Sheng
CS
Su
Wu-Chou
WC
Shieh
Dar-Bin
DB
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods; D004354:Drug Screening Assays, Antitumor; D042783:Endothelial Cells / Q000187:drug effects; D005290:Ferric Compounds / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006801:Humans; D008301:Maleimides / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D017239:Paclitaxel / Q000737:chemistry* / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000737:chemistry; D013388:Succinimides / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D005290:Ferric Compounds; D008301:Maleimides; D013388:Succinimides; C000499:ferric oxide; D011092:Polyethylene Glycols; D006046:Gold; D017239:Paclitaxel