The hypoglycaemic activity of the aqueous extract of Stachytarpheta angustifolia (Verbanaceae) in normoglycaemic and alloxan-induced diabetic rats.
The hypoglycaemic activity of the aqueous extract of Stachytarpheta angustifolia (Verbanaceae) was studied in normoglycaemic and alloxan-induced diabetic rats. The extract was administered orally to the rats and blood glucose level was monitored for 7 h. Results indicate that the aqueous extract (750 mg kg(-1)) produced a significant blood glucose reduction in both normoglycaemic and alloxan-induced diabetic rats (p < 0.05). The present result therefore appears to support the use of the plant aqueous extract for the management of type 2 diabetes by traditional medical practitioners in Northern Nigeria. The mechanism of action of the aqueous extract needs to be studied.
Isah
A B
AB
Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria.
Ibrahim
Y K E
YK
Abdulrahman
E M
EM
Ibrahim
M A
MA
D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008297:Male; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D029648:Verbenaceae / Q000737:chemistry*
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D000496:Alloxan