title: Optic disc area and retinal area in amblyopia.
abstract: OBJECTIVE
  To compare retinal area to optic disc rim area ratios of hyperopic normal, strabismic eyes with equal acuity, amblyopic, and fellow eyes.
  
  
  METHODS
  Neuroretinal rim areas of 293 amblyopic and fellow eyes, and 77 non-amblyopic hyperopic right eyes, and 84 non-amblyopic strabismic right eyes were measured by magnification corrected retinal photography and planimetry. Retinal area estimates were based on axial lengths.
  
  
  METHODS
  All subjects had bilateral hyperopia. Patients with glaucoma or known optic nerve atrophy were excluded. The normal and strabismic groups had equal visual acuity in each eye better than 20/40. The amblyopic group had acuity worse than 20/40 in one eye uncorrectable with lenses and without gross anatomic defects.
  
  
  RESULTS
  The amblyopic group included 137 with strabismus and 89 with anisometropia exceeding 1.5 diopters. There were highly significant differences between the ratio of retinal area to optic disc rim area of the amblyopic and of normal eyes (unpaired t-test, p = 8.6 x 10(-6)), the amblyopic and strabismic right eyes (unpaired t-test, p = 4.22 x 10(-8)) as well between the fellow and amblyopic eyes (paired t-test, p = 2.13 x 10(-5)). The difference between the normal and strabismic eyes without amblyopia was not significant (p = 0.82). There was a 20 percent increase in the retinal receptor areas of hyperopic amblyopic eyes as compared to hyperopic eyes without amblyopia despite reduced retinal areas in the amblyopic eyes. Dysplastic and/or asymmetric optic discs were present in 163 of 293 (56 percent) amblyopic patients, 47 of 84 (56 percent) strabismic, and 10 of 77 (13 percent) normal patients.
  
  
  CONCLUSIONS
  The increase in the receptor area may be an explanation for diminished acuity and impaired visual function in amblyopic eyes.
authors.affiliation: Cornell Medical Center, Ithaca, NY, USA.
authors.forename: Philip
authors.initials: P
authors.lastname: Lempert
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000550:Amblyopia / Q000150:complications / Q000473:pathology*; D015858:Anisometropia / Q000150:complications; D001699:Biometry; D002648:Child; D002675:Child, Preschool; D006801:Humans; D006956:Hyperopia / Q000150:complications; D008875:Middle Aged; D009898:Optic Disk / Q000002:abnormalities / Q000473:pathology*; D012160:Retina / Q000473:pathology*; D012189:Retrospective Studies; D013285:Strabismus / Q000150:complications; D055815:Young Adult