[Biochemical and morphological manifestations of endothelial dysfunction of endocardium and myocardial vessels during emotional stress in combination with hypercholesterolemia].
In experiments with white rats the influence of emotional and pain stress in combination with alimentary hypercholesterolemia on lipid content of membraneous structures of endotheliocytes of endocardium and microvessels of myocardium and their morphological manifestations has been studied. Combination of these etiological factors is followed by accumulation of free cholesterol and free fatty acids within the cells. This results in damage of single endotheliocytes, the most extreme manifestation of which is formation of endothelial bodies (cytoplasts) with development of microclasmatosis and desquamation of these cells.
Levyts'kyĭ
V A
VA
Luchko
I M
IM
D000818:Animals; D002855:Chromatography, Thin Layer; D003331:Coronary Vessels / Q000378:metabolism / Q000648:ultrastructure; D004195:Disease Models, Animal; D004699:Endocardium / Q000378:metabolism / Q000648:ultrastructure; D042783:Endothelial Cells / Q000378:metabolism / Q000648:ultrastructure; D004730:Endothelium, Vascular / Q000378:metabolism / Q000648:ultrastructure; D006937:Hypercholesterolemia / Q000150:complications / Q000378:metabolism / Q000473:pathology; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D008854:Microscopy, Electron; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure; D051381:Rats; D013315:Stress, Psychological / Q000150:complications / Q000378:metabolism / Q000473:pathology
D008055:Lipids