Comorbidities in polycystic ovary syndrome: their relationship to insulin resistance.
The polycystic ovary syndrome (PCOS) affects 5-10% of women of child-bearing age, and the diagnosis carries with it associated metabolic and cardiovascular risk factors that are likely linked to insulin resistance. Consequently, women affected by PCOS are at significant risk for developing type 2 diabetes mellitus, cardiovascular disease, and obstructive sleep apnea. Aggressive screening for glucose intolerance and cardiovascular risk factors should be performed in all PCOS patients, and, when indicated by symptomatology, affected women should be screened for sleep apnea. Long-term goals of therapy should focus on prevention of these comorbidities.
Bethea
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Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, USA. jnestler@mc vhvcu.edu
Nestler
J E
JE
D002318:Cardiovascular Diseases / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology; D015897:Comorbidity; D048909:Diabetes Complications / Q000453:epidemiology / Q000503:physiopathology; D050171:Dyslipidemias / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D024821:Metabolic Syndrome / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology* / Q000503:physiopathology; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology; D014481:United States / Q000453:epidemiology