title: Phenolic constituents from the stem bark of Magnolia officinalis.
abstract: Three new compounds, magnolianone (1), erythro-honokitriol (2), and threo-honokitriol (3), together with 14 known compounds, magnaldehyde (4), magnatriol B (5), randaiol (6), obovatol (7), magnolignan B (8a and 8b), magnolol, honokiol (9), p-hydroxylbenzaldehyde, coniferaldehyde, coniferol alcohol, syringaldehyde, syringaresinol, and acteoside, were isolated from the MeOH-soluble part of a water extract of the stem bark of Magnolia officinalis. Among these compounds, 2-8b were studied for anti-inflammatory and antioxidative activities. Compound 7 displayed more potent antioxidative potential than 9. Compounds 4-7 effectively inhibited LPS-induced NO production, whereas 5 and 6 were more potent than 9.
authors.affiliation: National Research Institute of Chinese Medicine, Taipei, 112, Taiwan, Republic of China.
authors.forename: Chien-Chang
authors.initials: CC
authors.lastname: Shen
authors.forename: Ching-Li
authors.initials: CL
authors.lastname: Ni
authors.forename: Yuh-Chiang
authors.initials: YC
authors.lastname: Shen
authors.forename: Yu-Ling
authors.initials: YL
authors.lastname: Huang
authors.forename: Ching-Hsia
authors.initials: CH
authors.lastname: Kuo
authors.forename: Tian-Shung
authors.initials: TS
authors.lastname: Wu
authors.forename: Chien-Chih
authors.initials: CC
authors.lastname: Chen
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003512:Cyclohexanones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017705:Lignans / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D031566:Magnolia / Q000737:chemistry*; D051379:Mice; D017628:Microglia / Q000187:drug effects; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000378:metabolism; D010851:Picrates / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013624:Taiwan
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D001713:Biphenyl Compounds; D003512:Cyclohexanones; D017705:Lignans; D008070:Lipopolysaccharides; D010851:Picrates; C535135:erythro-honokitriol; C535134:magnolianone; C535136:threo-honokitriol; D009569:Nitric Oxide; C004931:1,1-diphenyl-2-picrylhydrazyl