title: Development and perspective of current Brazilian studies on the epidemiology of childhood leukemia.
abstract: In this concise report, we describe the history and evolution of childhood acute leukemia studies in Brazil, and the application if key biomarkers for clinical trials and epidemiological studies over the past 8 years. Highlights of each ongoing study are summarized. A Brazilian network integrating hospitals and scientific institutions from all country regions has been established. This organization is made possible through informatics and computer networking, and the standardization of pathological reviews including immunophenotyping and molecular characterization of childhood leukemias. The unique characteristics of the Brazilian population combined with a large clinical and epidemiologic framework for patient ascertainment has enabled large-scale epidemiological studies on childhood leukemia in Brazil.
authors.affiliation: Hematology-Oncology Pediatric Program, Research Center, Instituto Nacional de Câncer, Rio de Janeiro, Brazil. mpombo@inca.gov.br
authors.forename: Maria S
authors.initials: MS
authors.lastname: Pombo de Oliveira
authors.forename: Sergio
authors.initials: S
authors.lastname: Koifman
authors.forename: Gisele M
authors.initials: GM
authors.lastname: Vasconcelos
authors.forename: Mariana
authors.initials: M
authors.lastname: Emerenciano
authors.forename: Cristiane
authors.initials: C
authors.lastname: de Oliveira Novaes
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D014408:Biomarkers, Tumor; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D004198:Disease Susceptibility; D004314:Down Syndrome / Q000453:epidemiology / Q000235:genetics; D005260:Female; D005544:Forecasting; D050982:GATA1 Transcription Factor / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D011495:Histone-Lysine N-Methyltransferase; D006761:Hospitals / Q000706:statistics & numerical data; D006801:Humans; D016130:Immunophenotyping; D015994:Incidence; D007223:Infant; D007255:Information Services / Q000458:organization & administration; D007938:Leukemia / Q000453:epidemiology* / Q000235:genetics / Q000276:immunology; D008297:Male; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics; D012042:Registries / Q000706:statistics & numerical data
chemical_list: D014408:Biomarkers, Tumor; D050982:GATA1 Transcription Factor; C494688:GATA1 protein, human; C497422:KMT2A protein, human; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase