In-vivo fluorescence imaging of mammalian organs using charge-assembled mesocapsule constructs containing indocyanine green.
Indocyanine green (ICG) is a fluorescent probe used in clinical imaging. However, its utility remains limited by optical instability, rapid circulation kinetics, and exclusive uptake by the liver. Using mesocapsule (MC) constructs to encapsulate ICG, we have developed a technology to stabilize ICG's optical properties and alter its biodistribution. We present in vivo fluorescence images of mammalian organs to demonstrate the potential application of our ICG encapsulation technology for optical imaging of specific tissues.
Yaseen
Mohammad A
MA
Department of Bioengineering, Rice University, MS-142 6100 Main St, Houston, TX 77005, USA.
Yu
Jie
J
Wong
Michael S
MS
Anvari
Bahman
B
D000818:Animals; D002214:Capsules; D003287:Contrast Media / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D005260:Female; D007089:Image Enhancement / Q000379:methods*; D007208:Indocyanine Green / Q000737:chemistry*; D051379:Mice; D008856:Microscopy, Fluorescence / Q000379:methods*; D014781:Viscera / Q000166:cytology*; D051598:Whole Body Imaging / Q000379:methods*
D002214:Capsules; D003287:Contrast Media; D004337:Drug Carriers; D007208:Indocyanine Green