title: Does multicentric/multifocal breast cancer differ from unifocal breast cancer? An analysis of survival and contralateral breast cancer incidence.
abstract: Purpose we evaluated whether patients with multifocal/multicentric (M/M) breast cancer have different outcomes compared to unifocal (U) disease in terms of survival and the development of contralateral breast cancer (CBC) disease. Methods women diagnosed with stage I-III breast cancer were classified as having U or M/M disease. Prognostic factors were prospectively collected and obtained from the breast cancer outcome unit database. Univariate and multivariable analyses for the incidence of CBC were performed as well as Kaplan-Meier plots. Results 25,320 women met inclusion criteria. The 5-year cumulative incidence of CBC in the U versus M/M group was 2.3% (95% CI 2.1, 2.5) versus 2.4% (95% CI 1.6, 3.4) (P = 0.349). Breast cancer specific survival (BCSS) rate revealed a slightly worse outcome with M/M disease, RR = 1.174 (95% CI 1,004, 1.372). Conclusions M/M breast cancer did not increase the risk of metachronous CBC, but was associated with inferior BCSS.
authors.affiliation: Division of Medical Oncology, British Columbia Cancer Agency, 600 w 10th Avenue, Vancouver, BC, Canada V5Z 4E6. ryerushalmi@bccancer.bc.ca
authors.forename: Rinat
authors.initials: R
authors.lastname: Yerushalmi
authors.forename: Hagen
authors.initials: H
authors.lastname: Kennecke
authors.forename: Ryan
authors.initials: R
authors.lastname: Woods
authors.forename: Ivo A
authors.initials: IA
authors.lastname: Olivotto
authors.forename: Caroline
authors.initials: C
authors.lastname: Speers
authors.forename: Karen A
authors.initials: KA
authors.lastname: Gelmon
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000401:mortality* / Q000473:pathology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary / Q000453:epidemiology* / Q000473:pathology; D011379:Prognosis
chemical_list: D000970:Antineoplastic Agents