title: [Molecular biology and prostate cancer: evolution or revolution?].
abstract: The identification of fusion genes provides new insights into the initial mechanisms of molecular events implicated in the tumorigenesis of prostate cancer. The presence of TEMPRSS2-ETS fusion in up to half of all human prostate cancers makes it perhaps the most common genetic rearrangement in human epithelial tumors. Some data suggest that TMPRSS2-ERG fusion prostate cancers have a more aggressive phenotype which may affect cancer progression and outcome in localized tumors treated with prostatectomy. This discovery should pave the way towards future targeted therapies.
authors.affiliation: Service de pathologie, groupe hospitalier Paris-Saint-Joseph, 185, rue Raymond-Losserand, 75014 Paris, France. vmolinie@hpsj.fr
authors.forename: Vincent
authors.initials: V
authors.lastname: Molinié
authors.forename: Philippe
authors.initials: P
authors.lastname: Beuzeboc
authors.forename: Wafa K
authors.initials: WK
authors.lastname: Mahjoub
mesh_terms: D002453:Cell Cycle / Q000235:genetics; D002455:Cell Division / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics; D004231:Diuresis; D050939:Gene Fusion; D016259:Genes, myc; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008967:Molecular Biology / Q000379:methods*; D009857:Oncogenes; D011468:Prostatectomy / Q000379:methods; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D050783:Proto-Oncogene Proteins c-ets / Q000235:genetics; D013489:Suppression, Genetic
chemical_list: D004273:DNA, Neoplasm; D005819:Genetic Markers; D050783:Proto-Oncogene Proteins c-ets