title: Glycosylated asterisks are among the most potent low valency inducers of Concanavalin A aggregation.
abstract: A new class of sulfurated, semi-rigid, radial and low-valent glycosylated asterisk ligands with potential dual function as ligand and probe has some of the highest inhibition potencies of Con A-induced hemagglutination, by using a cross-linking mechanism of Con A which amplifies the enhancement to near nanomolar concentrations with the alpha-d-mannose asterisk.
authors.affiliation: Laboratoire de Chimie Organique II-Glycochimie, UMR CNRS 5246, Université Claude Bernard - Lyon 1,Villeurbanne Cedex, France.
authors.forename: Mazen
authors.initials: M
authors.lastname: Sleiman
authors.forename: Annabelle
authors.initials: A
authors.lastname: Varrot
authors.forename: Jean-Manuel
authors.initials: JM
authors.lastname: Raimundo
authors.forename: Marc
authors.initials: M
authors.lastname: Gingras
authors.forename: Peter G
authors.initials: PG
authors.lastname: Goekjian
mesh_terms: D000818:Animals; D003208:Concanavalin A / Q000737:chemistry*; D006031:Glycosylation; D006386:Hemagglutination Tests; D011817:Rabbits
chemical_list: D003208:Concanavalin A