Aminoacid-derived mercaptoimidazoles.
Starting from suitably protected amino acids, mercaptoimidazoles were synthesized either from the acid or including the amine nitrogen itself. A preliminary optimisation study led to efficient conditions for the obtention of the imidazole ring. These conditions are compatible with the presence of amino acid or dipeptide scaffolds.
Crépin
Alain
A
Val-de-Pharm, Parc industriel d'Incarville, BP 606, 27106, Val-de-Reuil Cedex, France.
Wattier
Nicolas
N
Petit
Sylvain
S
Bischoff
Laurent
L
Fruit
Corinne
C
Marsais
Francis
F
D000143:Acids / Q000737:chemistry*; D020816:Amino Acid Motifs; D000596:Amino Acids / Q000737:chemistry*; D002625:Chemistry, Organic / Q000379:methods*; D004220:Disulfides / Q000737:chemistry; D006868:Hydrolysis; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D008670:Metals / Q000737:chemistry; D008956:Models, Chemical; D010447:Peptide Hydrolases / Q000737:chemistry; D010455:Peptides / Q000737:chemistry; D017434:Protein Structure, Tertiary
D000143:Acids; D000596:Amino Acids; D004220:Disulfides; D007093:Imidazoles; D008670:Metals; D010455:Peptides; D010447:Peptide Hydrolases