title: Medicinal chemistry approaches to the inhibition of dipeptidyl peptidase IV.
abstract: Inhibitors of dipeptidyl peptidase IV (DPP-4) have emerged as an important new class of therapeutic agents for type two diabetes. Various medicinal chemistry approaches have been applied to this area and have resulted in the identification of numerous late-stage development compounds. The discoveries of several of the most advanced DPP-4 inhibitors are reviewed.
authors.affiliation: Takeda San Diego, 10410 Science Center Drive, San Diego, CA 92121, USA. sgwaltney@takedasd.com
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Gwaltney
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives / Q000737:chemistry / Q000627:therapeutic use; D002626:Chemistry, Pharmaceutical; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D054873:Dipeptidyl-Peptidase IV Inhibitors / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000627:therapeutic use; D009570:Nitriles / Q000737:chemistry / Q000627:therapeutic use; D010880:Piperidines / Q000737:chemistry / Q000627:therapeutic use; D011759:Pyrrolidines / Q000737:chemistry / Q000627:therapeutic use; D014498:Uracil / Q000031:analogs & derivatives / Q000737:chemistry / Q000627:therapeutic use; D000077597:Vildagliptin
chemical_list: D054873:Dipeptidyl-Peptidase IV Inhibitors; D007004:Hypoglycemic Agents; D009570:Nitriles; D010880:Piperidines; D011759:Pyrrolidines; D014498:Uracil; D000077597:Vildagliptin; C520853:alogliptin; D000218:Adamantane