Nitroxyl radicals as low toxic spin-labels for non-invasive magnetic resonance imaging of blood-brain barrier permeability for conventional therapeutics.
The present study describes a novel non-radioactive methodology for in vivo non-invasive, real-time imaging of blood-brain barrier (BBB) permeability for conventional drugs, using nitroxyl radicals as spin-labels and magnetic resonance imaging (MRI).
Zhelev
Zhivko
Z
Department of Biophysics, Molecular Imaging Center, National Institute of Radiological Sciences, Inage-ku, Chiba 263-8555, Japan.
Bakalova
Rumiana
R
Aoki
Ichio
I
Matsumoto
Ken-Ichiro
K
Gadjeva
Veselina
V
Anzai
Kazunori
K
Kanno
Iwao
I
D000818:Animals; D000970:Antineoplastic Agents; D000975:Antioxidants; D001345:Autoradiography; D001812:Blood-Brain Barrier / Q000033:anatomy & histology* / Q000187:drug effects*; D003497:Cyclic N-Oxides; D004353:Drug Evaluation, Preclinical; D005609:Free Radicals / Q000737:chemistry*; D007202:Indicators and Reagents; D008130:Lomustine / Q000031:analogs & derivatives; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D017672:Nitrogen Compounds / Q000737:chemistry* / Q000633:toxicity; D009589:Nitrogen Oxides / Q000737:chemistry*; D010539:Permeability / Q000187:drug effects; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D049268:Positron-Emission Tomography; D013113:Spin Labels / Q000138:chemical synthesis*
D000970:Antineoplastic Agents; D000975:Antioxidants; D003497:Cyclic N-Oxides; D005609:Free Radicals; D007202:Indicators and Reagents; D017672:Nitrogen Compounds; D009589:Nitrogen Oxides; D004364:Pharmaceutical Preparations; D013113:Spin Labels; D008130:Lomustine; C039900:nitroxyl; C003959:TEMPO