title: [Clinical symptom relief in obese patients with persistent moderate asthma secondary to decreased obesity].
abstract: BACKGROUND
  The prevalence of asthma and obesity has increased last years implying important economical and social consequences. A relationship between asthma severity and obesity grade has been found. Therefore, it is necessary to evaluate if obesity decline has a beneficial impact on asthma severity.
  
  
  OBJECTIVE
  To evaluate the effect of obesity decline on control symptoms and asthma severity.
  
  
  METHODS
  Ninety-six patients with obesity and moderate chronic asthma were randomized to group A or B and were maintained for 40 days on a low calorie diet. At baseline and at the end of the study, symptoms, measurement of obesity, spirometry, inflammatory cytokines and immunoglobulin's levels were assessed. Diets' safety was evaluated based on laboratory test. Data were analyzed with Student's t test.
  
  
  RESULTS
  After 40 days on a low calorie diet, in group A, there were significant decreases of obesity (p < 0.001) and IgE, symptoms almost disappeared (cough persisted in 20%) and medication was suspended in 80%. Group B had obesity decline but IgE levels remained (> 100 UI/mL), symptoms and drug regimen remained unchanged. Both diets were not harmful for patients.
  
  
  CONCLUSIONS
  These results show that asthmatic obese patients maintained for 40 days on low calorie diet A, had obesity and IgE levels decrease and symptoms and asthma severity relief.
authors.affiliation: Departamento de laboratorio clínico y bioestadistica, Unidad Médica de Alta Especialidad, Hospital de Especialidades, Centro Médico Nacional Siglo XXI.
authors.forename: Azael
authors.initials: A
authors.lastname: Hernández Romero
authors.forename: Juan
authors.initials: J
authors.lastname: Matta Campos
authors.forename: Alejandra
authors.initials: A
authors.lastname: Mora Nieto
authors.forename: Leonel
authors.initials: L
authors.lastname: del Rivero
authors.forename: Atenea Estela
authors.initials: AE
authors.lastname: Andrés Dionicio
authors.forename: Pilar
authors.initials: P
authors.lastname: Aguilar Ramírez
authors.forename: Carlos
authors.initials: C
authors.lastname: Barthell Solís
authors.forename: América
authors.initials: A
authors.lastname: García González
authors.forename: Leticia
authors.initials: L
authors.lastname: Carreta Macías
authors.forename: Ricardo
authors.initials: R
authors.lastname: Murguía Corral
authors.forename: Francisco
authors.initials: F
authors.lastname: Vázquez Nava
authors.forename: Víctor Manuel
authors.initials: VM
authors.lastname: Almeida Arvizu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use; D001249:Asthma / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D016207:Cytokines / Q000097:blood; D004038:Diet, Reducing; D002149:Energy Intake; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000178:diet therapy* / Q000503:physiopathology; D011446:Prospective Studies; D013147:Spirometry; D015431:Weight Loss
chemical_list: D018927:Anti-Asthmatic Agents; D016207:Cytokines; D007136:Immunoglobulins; D007073:Immunoglobulin E