title: Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.
abstract: Obesity results from the interaction of genetic and environmental factors. To search for sequence variants that affect variation in two common measures of obesity, weight and body mass index (BMI), both of which are highly heritable, we performed a genome-wide association (GWA) study with 305,846 SNPs typed in 25,344 Icelandic, 2,998 Dutch, 1,890 European Americans and 1,160 African American subjects and combined the results with previously published results from the Diabetes Genetics Initiative (DGI) on 3,024 Scandinavians. We selected 43 variants in 19 regions for follow-up in 5,586 Danish individuals and compared the results to a genome-wide study on obesity-related traits from the GIANT consortium. In total, 29 variants, some correlated, in 11 chromosomal regions reached a genome-wide significance threshold of P < 1.6 x 10(-7). This includes previously identified variants close to or in the FTO, MC4R, BDNF and SH2B1 genes, in addition to variants at seven loci not previously connected with obesity.
authors.affiliation: deCODE Genetics, Reykjavik, Iceland. thorleif@decode.is
authors.forename: Gudmar
authors.initials: G
authors.lastname: Thorleifsson
authors.forename: G Bragi
authors.initials: GB
authors.lastname: Walters
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Gudbjartsson
authors.forename: Valgerdur
authors.initials: V
authors.lastname: Steinthorsdottir
authors.forename: Patrick
authors.initials: P
authors.lastname: Sulem
authors.forename: Anna
authors.initials: A
authors.lastname: Helgadottir
authors.forename: Unnur
authors.initials: U
authors.lastname: Styrkarsdottir
authors.forename: Solveig
authors.initials: S
authors.lastname: Gretarsdottir
authors.forename: Steinunn
authors.initials: S
authors.lastname: Thorlacius
authors.forename: Ingileif
authors.initials: I
authors.lastname: Jonsdottir
authors.forename: Thorbjorg
authors.initials: T
authors.lastname: Jonsdottir
authors.forename: Elinborg J
authors.initials: EJ
authors.lastname: Olafsdottir
authors.forename: Gudridur H
authors.initials: GH
authors.lastname: Olafsdottir
authors.forename: Thorvaldur
authors.initials: T
authors.lastname: Jonsson
authors.forename: Frosti
authors.initials: F
authors.lastname: Jonsson
authors.forename: Knut
authors.initials: K
authors.lastname: Borch-Johnsen
authors.forename: Torben
authors.initials: T
authors.lastname: Hansen
authors.forename: Gitte
authors.initials: G
authors.lastname: Andersen
authors.forename: Torben
authors.initials: T
authors.lastname: Jorgensen
authors.forename: Torsten
authors.initials: T
authors.lastname: Lauritzen
authors.forename: Katja K
authors.initials: KK
authors.lastname: Aben
authors.forename: André L M
authors.initials: AL
authors.lastname: Verbeek
authors.forename: Nel
authors.initials: N
authors.lastname: Roeleveld
authors.forename: Ellen
authors.initials: E
authors.lastname: Kampman
authors.forename: Lisa R
authors.initials: LR
authors.lastname: Yanek
authors.forename: Lewis C
authors.initials: LC
authors.lastname: Becker
authors.forename: Laufey
authors.initials: L
authors.lastname: Tryggvadottir
authors.forename: Thorunn
authors.initials: T
authors.lastname: Rafnar
authors.forename: Diane M
authors.initials: DM
authors.lastname: Becker
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Gulcher
authors.forename: Lambertus A
authors.initials: LA
authors.lastname: Kiemeney
authors.forename: Oluf
authors.initials: O
authors.lastname: Pedersen
authors.forename: Augustine
authors.initials: A
authors.lastname: Kong
authors.forename: Unnur
authors.initials: U
authors.lastname: Thorsteinsdottir
authors.forename: Kari
authors.initials: K
authors.lastname: Stefansson
mesh_terms: D001483:Base Sequence; D015992:Body Mass Index; D001835:Body Weight / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D015894:Genome, Human / Q000235:genetics; D055106:Genome-Wide Association Study; D006801:Humans; D009765:Obesity / Q000150:complications / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D040641:Quantitative Trait Loci / Q000235:genetics*; D019655:Quantitative Trait, Heritable