title: [Pathogens and drug resistance of pulmonary infection in AIDS patients].
abstract: OBJECTIVE
  To study the pathogens and drug resistance profiles of pulmonary infection in patients with AIDS.
  
  
  METHODS
  The pathogens and their drug susceptibility of pulmonary infection diagnosed by fibrobronchoscopy-induced bronchoalveolar lavage fluid (BALF) culture and/or transbronchial biopsy in 116 AIDS cases were analyzed.
  
  
  RESULTS
  Monopathogenic infection in lungs were detected in 18 cases (15.5%) and mixed infection in 98 cases (84.5%). Of the 116 cases, bacteria were present in 91 patients, fungi in 62, tubercle bacillus in 49, pneumocystis jiroveci in 29, and cytomegalovirus in 11. Ninety-five bacterial strains were isolated from BALF, mainly including Streptococci (34), coagulase negative Staphylococcus (20), Klebsiella pneumoniae (10) and Escherichia (7). The isolated bacteria were resistant to beta-lactam, macrolides, quinolones and aminoglycosides, of which were 14 methicillin-resistant Streptococci (MRS) strains and 12 extended spectrum beta-lactamases (ESBL) strains. Sixty-eight fungal strains were isolated, including 36 Candida mycoderma, 19 Penicillium, 6 Aspergilli and 5 Mold fungi; they were sensitive to amphotericin B but resistant to fluconazole (5.6% - 50.0%) and itraconazole (10.5% - 60.0%).
  
  
  CONCLUSIONS
  Pneumonia in AIDS patients are usually caused by multiple pathogens, predominantly consisting of multiresistant bacteria and fungi. Therefore, antibiotics should be rationally chosen according to drug susceptibility test.
authors.affiliation: Department of Infectious Diseases, Guangzhou No.8 People's Hospital, Guangzhou 510060, China.
authors.forename: Ling-Hua
authors.initials: LH
authors.lastname: Li
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Tang
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Cai
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000382:microbiology*; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003586:Cytomegalovirus Infections; D004351:Drug Resistance; D024881:Drug Resistance, Bacterial; D018432:Drug Resistance, Multiple; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011020:Pneumonia, Pneumocystis; D011024:Pneumonia, Viral; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000382:microbiology*; D014397:Tuberculosis, Pulmonary
chemical_list: D000900:Anti-Bacterial Agents