(123)I-FP-CIT SPET striatal uptake in parkinsonian patients with the alpha-synuclein (G209A) mutation A.
Autosomal dominant familial Parkinson's disease (PD) due to the alpha-synuclein (G209A) mutation shares similar clinical characteristics with sporadic PD. Pathological studies however indicate more widespread neuronal degeneration in the familial form. We performed (123)I-FP-CIT SPET (DaTSCAN) study in nine patients with familial PD carrying the alpha-synuclein (G209A) mutation and fifteen matched patients with sporadic disease. Both groups had equal radioligand reduction uptake in the striatum but the alpha-synuclein patients showed less asymmetry and increased putamen to caudate ratio. Our findings indicate that there are minor differences in DAT SPET parameters between alpha-synuclein and sporadic PD patients insufficient to provide differential diagnosis.
Bostantjopoulou
Sevasti
S
3rd University Department of Neurology, Thessaloniki, Greece. bostkamb@otenet.gr
Katsarou
Zoe
Z
Gerasimou
George
G
Costa
Durval C
DC
Gotzamani-Psarrakou
Anna
A
D000328:Adult; D003342:Corpus Striatum / Q000378:metabolism; D006801:Humans; D007457:Iodine Radioisotopes; D008875:Middle Aged; D009154:Mutation; D010300:Parkinson Disease / Q000000981:diagnostic imaging / Q000235:genetics / Q000378:metabolism*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D014326:Tropanes / Q000493:pharmacokinetics*; D051844:alpha-Synuclein / Q000235:genetics*
D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D014326:Tropanes; D051844:alpha-Synuclein; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane