IKK/NF-kappaB signaling in intestinal epithelial cells controls immune homeostasis in the gut.
The intestinal epithelium regulates the interaction between commensal bacteria and the immune system not only by providing a physical barrier but also by expressing a number of immunoregulatory and antimicrobial peptides. Recent studies showed that inhibition of IkappaB kinase (IKK)/nuclear factor-kappaB (NF-kappaB) signaling specifically in intestinal epithelial cells in vivo causes the spontaneous development of intestinal inflammation in mice. These findings identify IKK/NF-kappaB signaling in intestinal epithelial cells as an important factor for the maintenance of epithelial integrity and immune homeostasis in the gut.
Pasparakis
M
M
Institute for Genetics, University of Cologne, Cologne, Germany. pasparakis@uni-koeln.de
D000818:Animals; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism*; D006706:Homeostasis / Q000276:immunology*; D006801:Humans; D051550:I-kappa B Kinase / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000166:cytology / Q000276:immunology*; D016328:NF-kappa B / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology*
D016328:NF-kappa B; D051550:I-kappa B Kinase