title: [Physiopathology, diagnosis and management of bone metastases from prostate cancer].
abstract: Bone metastasis is very frequent in prostate cancer. Diagnosis is generally easy to make with scintigraphy and it can be confirmed by TDM and RMI. Before metastasis become symptomatic, treatment includes physical and nutritional advice with drugs to prevent bone events (pain, fracture, compression and hypercalcemia). Associated with a effective hormonal treatment, radiotherapy, surgery and analgesics are the principal treatments for symptomatic bone metastasis. Bisphosphonates play a very important role to prevent bone mass loss and to reduce bone complication events. Endothelin inhibitors belong to a new exciting concept to treat these bone metastases, data are needed in order to use them routinely.
authors.affiliation: Service d'Urologie, Hôpital Foch, Faculté de médecine Paris-Ile-de-France-Ouest, UVSQ, France. t.lebret@hopital-foch.org
authors.forename: T
authors.initials: T
authors.lastname: Lebret
authors.forename: A
authors.initials: A
authors.lastname: Méjean
mesh_terms: D001859:Bone Neoplasms / Q000175:diagnosis / Q000503:physiopathology / Q000556:secondary* / Q000628:therapy; D004164:Diphosphonates / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000473:pathology*
chemical_list: D004164:Diphosphonates