Chenodeoxycholate is an inhibitor of Clostridium difficile spore germination.
Some cholate derivatives that are normal components of bile can act with glycine to induce the germination of Clostridium difficile spores, but at least one bile component, chenodeoxycholate, does not induce germination. Here we show that chenodeoxycholate inhibits the germination of C. difficile spores in response to cholate and taurocholate.
Sorg
Joseph A
JA
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA.
Sonenshein
Abraham L
AL
D002635:Chenodeoxycholic Acid / Q000494:pharmacology*; D020355:Cholates / Q000494:pharmacology; D016360:Clostridioides difficile / Q000187:drug effects* / Q000502:physiology*; D013171:Spores, Bacterial / Q000187:drug effects / Q000502:physiology; D013656:Taurocholic Acid / Q000494:pharmacology
D020355:Cholates; D002635:Chenodeoxycholic Acid; D013656:Taurocholic Acid