title: [Efficacy and safety of compound azintamide on dyspepsia symptoms in a multicentre self-controlled trial].
abstract: OBJECTIVE
  To investigate the efficacy and safety of compound azintamide on dyspepsia symptoms.
  
  
  METHODS
  One hundred and eighty dyspepsia patients were divided into two groups according to dyspepsia symptom related with gastrointestinal disease (group A) or biliary system disease (group B), whose dyspepsia symptom were not improved by the Domperidone 10 mg tid for 2 weeks. Two tablets of compound azintamide were administered orally following a meal, tid for 2 weeks. The changes of symptoms score of upper abdominal distention, upper abdominal pain or discomfort anorexia and effective rate as well as adverse events were recorded.
  
  
  RESULTS
  Compound azintamide greatly improved the symptoms of upper abdominal distention, upper abdominal pain or discomfort and anorexia. All symptoms scores were significantly decreased after 2 weeks of compound azintamide (P < 0.01). The effective rate of each symptom and total symptoms score were more than 84.9% and 92.5%. One patient reported mild rash at the fourteenth days, which disappeared 3 days later.
  
  
  CONCLUSIONS
  Compound azintamide showed effective and safety in treatment of patient with dyspepsia symptoms when Domperidone therapy is not satisfactory.
authors.affiliation: Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Li-ming
authors.initials: LM
authors.lastname: Zhu
authors.forename: Jia-ming
authors.initials: JM
authors.lastname: Qian
authors.forename: Le
authors.initials: L
authors.lastname: Xu
authors.forename: Hong-chuan
authors.initials: HC
authors.lastname: Zhao
authors.forename: Yun-sheng
authors.initials: YS
authors.lastname: Yang
authors.forename: Mei
authors.initials: M
authors.lastname: Zhang
authors.forename: Yu-lan
authors.initials: YL
authors.lastname: Liu
authors.forename: Peng-yan
authors.initials: PY
authors.lastname: Xie
authors.forename: Jian-yu
authors.initials: JY
authors.lastname: Hao
authors.forename: Shao-mei
authors.initials: SM
authors.lastname: Han
mesh_terms: D000328:Adult; D004415:Dyspepsia / Q000188:drug therapy*; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011724:Pyridazines / Q000627:therapeutic use*
chemical_list: D005765:Gastrointestinal Agents; D011724:Pyridazines; C011673:azintamid