[Expression of cyclooxygenase-2 in bladder transitional cell carcinoma and the significance thereof].
OBJECTIVE
To study the expression of cyclooxygenase-2 (COX-2) in bladder transitional cell carcinoma (Tcc) and the clinical significance thereof.


METHODS
Immunohistochemistry was used to detect the expression of COX-2 in 56 specimens of bladder Tcc and 10 specimens of normal bladder tissue, all resected during operation.


RESULTS
No expression of COX-2 was detected in the 10 specimens of normal bladder tissue and in the 56 specimens of bladder Tcc the positive rate of COX-2 was 55.36%. The expression of COX-2 in bladder Tcc was closely correlated with the grade and stage of tumor (both P < 0.01).


CONCLUSIONS
COX-2 expression in bladder Tcc is closely correlated with the grade and stage.
Yu
Lei
L
Department of Urology, First Hospital of Harbin, Harbin 150010, China. yuleidoctor@yahoo.com.cn
Chen
Xiao-jiang
XJ
Shi
Pei-qing
PQ
Ding
Qiang
Q
Sun
Chang-hua
CH
Liu
Guo-bin
GB
Shi
Dong-min
DM
Huang
Yong-gang
YG
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002295:Carcinoma, Transitional Cell / Q000378:metabolism* / Q000473:pathology; D051546:Cyclooxygenase 2 / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D001749:Urinary Bladder Neoplasms / Q000378:metabolism* / Q000473:pathology
D051546:Cyclooxygenase 2