title: Pharmacokinetics of florfenicol after intravenous and intramuscular administration in New Zealand White rabbits.
abstract: The pharmacokinetic disposition and bioavailability of florfenicol (FF) were determined after single intravenous (i.v.) and intramuscular (i.m.) administrations of 25mg/kg b.w. to ten healthy New Zealand White rabbits. Plasma FF concentrations were determined by high-performance liquid chromatography (HPLC). The plasma pharmacokinetic values for FF were best described by a one-compartment open model. The elimination half-life (t(1/2beta)) was different (p<0.05) however, the area under curve (AUC) was similar (p>0.05) after i.v. and i.m. administrations. FF was rapidly eliminated (t(1/2beta) 1.49+/-0.23 h), slowly absorbed and high (F, 88.75+/-0.22%) after i.m. injection. In addition, FF was widely distributed to the body tissues (V(ss) 0.98+/-0.05 L/kg) after i.v. injection. In this study the time that plasma concentration exceeded the concentration of 2 microg/mL was approximately 6h. For bacteria with MIC of 2 microg/mL, frequent administration at this dose would be needed to maintain the concentration above the MIC. However, it is possible that rabbit pathogens may have MIC values less than 2 microg/mL which would allow for less frequent administration. Further studies are necessary to identify the range of MIC values for rabbit pathogens and to identify the most appropriate PK-PD parameter needed to predict an effective dose.
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Atatürk University, Erzurum 25400, Turkey. feridekoc@yahoo.com
authors.forename: F
authors.initials: F
authors.lastname: Koc
authors.forename: M
authors.initials: M
authors.lastname: Ozturk
authors.forename: Y
authors.initials: Y
authors.lastname: Kadioglu
authors.forename: E
authors.initials: E
authors.lastname: Dogan
authors.forename: L E
authors.initials: LE
authors.lastname: Yanmaz
authors.forename: Z
authors.initials: Z
authors.lastname: Okumus
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D006207:Half-Life; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D011817:Rabbits; D013839:Thiamphenicol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics
chemical_list: D000900:Anti-Bacterial Agents; C035534:florfenicol; D013839:Thiamphenicol