title: CGH-1 and the control of maternal mRNAs.
abstract: Development requires the translation of stored maternal messenger RNAs (mRNAs) in a spatial and temporally specified manner. Maternal mRNAs are often in large RNA-protein (RNP) granules. Recent papers reveal that maternal mRNA granules in Caenorhabditis elegans oocytes and early development are dynamic and related to P-bodies and stress granules, which are conserved RNP granules seen in somatic cells. In addition, a highly conserved putative RNA helicase, termed CGH-1 in C. elegans, is now shown to be important for both for translation repression and the stability of stored mRNAs. The analysis of CGH-1 ortholog functions in somatic cells and its interacting proteins indicate possible mechanisms by which this protein family might stabilize stored maternal mRNAs.
authors.affiliation: Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, University of Arizona, Tucson, AZ 85721-0106, USA.
authors.forename: Purusharth
authors.initials: P
authors.lastname: Rajyaguru
authors.forename: Roy
authors.initials: R
authors.lastname: Parker
mesh_terms: D000818:Animals; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D014176:Protein Biosynthesis / Q000235:genetics; D012316:RNA Nucleotidyltransferases / Q000145:classification / Q000378:metabolism*; D020871:RNA Stability; D023121:RNA, Messenger, Stored / Q000235:genetics / Q000378:metabolism*
chemical_list: D023121:RNA, Messenger, Stored; D012316:RNA Nucleotidyltransferases