Effects of vitamin D receptor gene polymorphisms on low-resistance training using exercise machines: the 'Power Rehabilitation' program.
The enhancement and promotion of health is necessary to maintain the quality of life (QOL) of the aged population in developed nations such as Japan where the number of elderly has been increasing rapidly. For this purpose, low-resistance training using exercise machines ('Power Rehabilitation') has been established as a rehabilitation program. To investigate the individual factors which influence the effects of 'Power Rehabilitation', single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene and the ciliary neurotrophic factor (CNTF) gene were analyzed, and the relationship between SNP patterns and the effects of 'Power Rehabilitation' was evaluated. 'Power Rehabilitation' had an effect on the physiological functions involved in the activities of daily life (ADL) rather than muscle strength and size. In addition, certain SNP patterns showed better improvement of parameters associated with the effects of 'Power Rehabilitation' as analyzed by comparison between SNP patterns and factor analysis. Large scale analyses are required to ensure this tendency and to discover individual factors which may help to promote the health and QOL of the aged population.
Murakami
Shin-Ichiro
S
Fukushima Rehabilitation Academy, 18089-31 Yorishima, Asakuchi 714-0101, Japan.
Otsuki
Takemi
T
Maeda
Megumi
M
Miura
Yoshie
Y
Morii
Seiko
S
Kiyokane
Kenji
K
Hayakawa
Shin-Ichi
S
Maeda
Atsushi
A
Imakawa
Takayo
T
Harada
Shunpei
S
Handa
Torataro
T
Nishimura
Yasumitsu
Y
Murakami
Shuko
S
Kumagai
Naoko
N
Hayashi
Hiroaki
H
Chen
Ying
Y
Suemori
Shin-Ichiro
S
Fukushima
Yumiko
Y
Nishida
Seikoh
S
Fukushima
Keisuke
K
D000203:Activities of Daily Living; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D020934:Ciliary Neurotrophic Factor / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011788:Quality of Life; D018167:Receptors, Calcitriol / Q000235:genetics*; D012046:Rehabilitation; D055070:Resistance Training
D020934:Ciliary Neurotrophic Factor; D018167:Receptors, Calcitriol