title: Genomic polymorphism in the population of Candida glabrata: gene copy-number variation and chromosomal translocations.
abstract: The genomic sequence of the type strain of the opportunist human pathogen Candida glabrata (CBS138, ATCC 2001) is available since 2004. This allows the analysis of genomic structure of other strains by comparative genomic hybridization. We present here the molecular analysis of a collection of 183 C. glabrata strains isolated from patients hospitalized in France and around the world. We show that the mechanisms of microevolution within this asexual species include rare reciprocal chromosomal translocations and recombination within tandem arrays of repeated genes, and that these account for the frequent size heterogeneity between chromosomes across strains. Gene tandems often encode cell wall proteins suggesting a possible role in adaptation to the environment.
authors.affiliation: Institut Pasteur, Unité de Génétique Moléculaire des Levures, UPMC Univ Paris 06, CNRS URA 2171, 25 rue du Dr Roux, Paris, France. hmuller@jhsph.edu
authors.forename: Héloïse
authors.initials: H
authors.lastname: Muller
authors.forename: Agnès
authors.initials: A
authors.lastname: Thierry
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Coppée
authors.forename: Catherine
authors.initials: C
authors.lastname: Gouyette
authors.forename: Christophe
authors.initials: C
authors.lastname: Hennequin
authors.forename: Odile
authors.initials: O
authors.lastname: Sismeiro
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Talla
authors.forename: Bernard
authors.initials: B
authors.lastname: Dujon
authors.forename: Cécile
authors.initials: C
authors.lastname: Fairhead
mesh_terms: D041221:Candida glabrata / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D002177:Candidiasis / Q000382:microbiology; D055028:Comparative Genomic Hybridization; D004271:DNA, Fungal / Q000235:genetics*; D019143:Evolution, Molecular; D018628:Gene Dosage; D016681:Genome, Fungal; D006801:Humans; D011110:Polymorphism, Genetic; D011995:Recombination, Genetic; D020080:Tandem Repeat Sequences; D014178:Translocation, Genetic
chemical_list: D004271:DNA, Fungal