title: A synthetic lectin for O-linked beta-N-acetylglucosamine.
abstract: Changing employment: Receptor 1 binds beta-N-acetylglucosaminyl (beta-GlcNAc) up to 100 times more strongly than it does glucose. This synthetic lectin shows affinities similar to wheat germ agglutinin (WGA), a natural lectin used to bind GlcNAc. Remarkably, 1 is more selective than WGA. It favors especially the glycoside unit in glycopeptide 2, a model of the serine-O-GlcNAc posttranslational protein modification.
authors.affiliation: School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK.
authors.forename: Yann
authors.initials: Y
authors.lastname: Ferrand
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Klein
authors.forename: Nicholas P
authors.initials: NP
authors.lastname: Barwell
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Crump
authors.forename: Jesus
authors.initials: J
authors.lastname: Jiménez-Barbero
authors.forename: Cristina
authors.initials: C
authors.lastname: Vicent
authors.forename: Geert-Jan
authors.initials: GJ
authors.lastname: Boons
authors.forename: Sampat
authors.initials: S
authors.lastname: Ingale
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Davis
mesh_terms: D000117:Acetylglucosamine / Q000031:analogs & derivatives / Q000737:chemistry* / Q000378:metabolism; D000595:Amino Acid Sequence; D002241:Carbohydrates / Q000737:chemistry; D007700:Kinetics; D037102:Lectins / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D011499:Protein Processing, Post-Translational; D014909:Wheat Germ Agglutinins / Q000378:metabolism
chemical_list: D002241:Carbohydrates; D037102:Lectins; D014909:Wheat Germ Agglutinins; D000117:Acetylglucosamine