title: Clinical significance of plasma mannose concentrations in healthy and diabetic dogs.
abstract: Circulating levels of monosaccharides can act as a reflection of systemic glucose/ energy metabolism. Characteristic changes observed in these levels can be seen in patients with diabetes and other metabolic disorders. There have been a few reports describing the significance of mannose metabolism as an energy source under physiological and pathological conditions. However, the relationship between circulating levels of mannose and the pathophysiology of diabetes mellitus are unknown in dogs. This study examined circulating levels of mannose between healthy control and diabetic dogs and evaluated the clinical significance of mannose levels in dogs. Diabetic dogs demonstrated a higher circulating level of mannose in comparison to normal healthy control dogs. Plasma mannose was positively correlated with plasma glucose and fructosamine, respectively. Interestingly, plasma mannose levels were affected by plasma insulin levels. In the context of feeding and glucose tolerance tests, plasma mannose levels responded to changes in circulating insulin levels. Circulating plasma mannose levels decreased after feeding in both control and diabetic animals in spite of observed insulin level differences. However, when glucose tolerance tests were given, a positive correlation between mannose levels and insulin levels was observed. Therefore, plasma mannose levels obtained via glucose tolerance testing may be used as a new diagnostic method for evaluating insulin resistance or deficiency in diabetic dogs.
authors.affiliation: Department of Veterinary Science, Nippon Veterinary and Life Science University, Musashino, Tokyo, 180-8602, Japan. d0608@nvlu.ac.jp
authors.forename: A
authors.initials: A
authors.lastname: Mori
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: P
authors.initials: P
authors.lastname: Lee
authors.forename: M
authors.initials: M
authors.lastname: Furuuchi
authors.forename: H
authors.initials: H
authors.lastname: Tazaki
authors.forename: K
authors.initials: K
authors.lastname: Katayama
authors.forename: H
authors.initials: H
authors.lastname: Mizutani
authors.forename: T
authors.initials: T
authors.lastname: Sako
authors.forename: T
authors.initials: T
authors.lastname: Arai
mesh_terms: D000818:Animals; D001786:Blood Glucose; D003920:Diabetes Mellitus / Q000097:blood / Q000662:veterinary*; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D005260:Female; D007328:Insulin / Q000097:blood; D008297:Male; D008358:Mannose / Q000097:blood*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008358:Mannose