Should we target allergen protease activity to decrease the burden of allergic airway inflammation?
The prevalence of allergy and asthma has been increasing steadily in the developed world. Despite the growing health problems associated with these conditions few new therapeutic options are becoming available. Relatively recent developments have identified a role for proteases in promoting allergic sensitisation and allergic airway inflammation. It is also known that most major allergens have associated protease activity that is closely related to their efficacy to induce sensitization and inflammation. Here we review the evidence for the significance of protease activity in allergic airway disease and offer suggestions as to where the field could progress.
Vliagoftis
Harissios
H
Pulmonary Research Group, University of Alberta, Edmonton, Alberta, Canada. harissios.vliagoftis@ualberta.ca
Forsythe
Paul
P
D000485:Allergens / Q000187:drug effects*; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000494:pharmacology / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy; D006801:Humans; D009784:Occupational Diseases / Q000188:drug therapy; D010447:Peptide Hydrolases / Q000502:physiology*; D011480:Protease Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use*; D044462:Receptors, Proteinase-Activated / Q000187:drug effects / Q000502:physiology; D012130:Respiratory Hypersensitivity / Q000188:drug therapy* / Q000473:pathology
D000485:Allergens; D018927:Anti-Asthmatic Agents; D011480:Protease Inhibitors; D044462:Receptors, Proteinase-Activated; D010447:Peptide Hydrolases