CSF alpha-synuclein levels in dementia with Lewy bodies and Alzheimer's disease.
Dementia with Lewy bodies (DLB) is characterized by widespread depositions of alpha-synuclein, which are described as Lewy bodies. Recently, it was shown that neuronal cells in culture constitutively release alpha-synuclein into the culture medium and that alpha-synuclein is normally present in human cerebrospinal fluid (CSF). The aim of the present study was to evaluate the diagnostic value of CSF alpha-synuclein levels in discriminating DLB from Alzheimer's disease (AD). Alpha-synuclein was measured in CSF from 16 patients with DLB and 21 patients with AD. Iodine-123 metaiodobenzylguanidine cardiac scintigraphy was also performed to assess Lewy body pathology. CSF alpha-synuclein levels did not differ significantly between DLB and AD patients. However, the duration of illness was associated with lower alpha-synuclein levels (p<0.05) in DLB, while no such association was found in AD. The present data show CSF alpha-synuclein levels are not sensitive diagnostic markers to discriminate DLB from AD. However, the lower alpha-synuclein levels in DLB patients with longer duration suggest a reduction in CSF alpha-synuclein in association with increased severity of alpha-synucleinopathy in the brain.
Noguchi-Shinohara
Moeko
M
Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
Tokuda
Takahiko
T
Yoshita
Mitsuhiro
M
Kasai
Takashi
T
Ono
Kenjiro
K
Nakagawa
Masanori
M
El-Agnaf
Omar M A
OM
Yamada
Masahito
M
D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000235:genetics / Q000503:physiopathology; D016229:Amyloid beta-Peptides / Q000032:analysis / Q000378:metabolism; D001057:Apolipoproteins E / Q000235:genetics; D015415:Biomarkers / Q000032:analysis / Q000134:cerebrospinal fluid; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D005838:Genotype; D006321:Heart / Q000294:innervation / Q000503:physiopathology; D006801:Humans; D007457:Iodine Radioisotopes; D020961:Lewy Body Disease / Q000134:cerebrospinal fluid* / Q000235:genetics / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging; D011237:Predictive Value of Tests; D017779:Sympathetic Fibers, Postganglionic / Q000503:physiopathology; D051844:alpha-Synuclein / Q000032:analysis / Q000134:cerebrospinal fluid*; D016875:tau Proteins / Q000032:analysis / Q000378:metabolism
D016229:Amyloid beta-Peptides; D001057:Apolipoproteins E; D015415:Biomarkers; D007457:Iodine Radioisotopes; D051844:alpha-Synuclein; D016875:tau Proteins