Role of bone in osteoarthritis pathogenesis.
Much of the attention in developing diagnostic tools and therapeutic interventions for the management of osteoarthritis (OA) has focused on the preservation or repair of articular cartilage. It is clear that all of the joint components, including the ligaments, tendons, capsule, synovial lining, and periarticular bone, undergo structural and functional alterations during the course of OA progression. This article focuses on the specific skeletal features of OA and the putative mechanisms involved in their pathogenesis.
Goldring
Steven R
SR
The Hospital for Special Surgery, Weill College of Medicine of Cornell University, 535 East 70th Street, New York, NY 10021, USA. goldrings@hss.edu
D016723:Bone Remodeling / Q000502:physiology; D001842:Bone and Bones / Q000473:pathology* / Q000503:physiopathology*; D002358:Cartilage, Articular / Q000503:physiopathology; D006801:Humans; D007596:Joints / Q000473:pathology / Q000503:physiopathology; D010003:Osteoarthritis / Q000473:pathology* / Q000503:physiopathology*; D054850:Osteophyte / Q000503:physiopathology