Tumors of testis and midgut in aging flies.
In order to better understand the pathology of aging in the fly we used standard techniques of surgical pathology to conduct a histologic screen of approximately 1400 adult male flies ranging in age from one to five weeks. We found that flies developed tumors of the testis and gut and that the incidence of these tumors increased with age. Aging is the greatest single risk factor for the development of tumors in the general human population. Here, we show for the first time that aging is also a risk factor for tumor development in flies. These findings in one of the world's best-studied and genetically tractable model organisms open up opportunities for deeper experimental exploration of the relationship between aging and neoplasia.
Salomon
Robert N
RN
Department of Pathology, Tufts Medical Center, Boston, Massachusetts 02111, USA. rsalomon@tuftsmedicalcenter.org
Jackson
F Rob
FR
D000375:Aging; D000818:Animals; D004064:Digestive System / Q000473:pathology; D004331:Drosophila melanogaster / Q000166:cytology / Q000502:physiology*; D008297:Male; D009369:Neoplasms / Q000473:pathology; D013737:Testis / Q000473:pathology