title: The preparation and in vitro antiproliferative activity of phthalimide based ketones on MDAMB-231 and SKHep-1 human carcinoma cell lines.
abstract: The 'one pot' condensation reaction for the synthesis and potent antiproliferative inhibition of alpha-phthalimide based ketones is reported here. 2-Phthalimide-1-(4-fluoro-phenyl)ethanone (5) showed the best growth inhibition on human MDAMB-231 breast carcinoma and SKHep-1 hepatoma cell lines. Preliminary studies showed that the reported bioactivity may be due to the presence of strong electronegative fluorine group at the para-position of the aryl ring.
authors.affiliation: Lo Ka Chung Centre for Natural Anti-cancer Drug Development (Laboratory B), Departement of Applied Biology and Chemical Technology, Institute of Textiles and Clothing, Hong Kong Polytechnic University, 852 Hong Kong, China.
authors.forename: Sau Hing
authors.initials: SH
authors.lastname: Chan
authors.forename: Kim Hung
authors.initials: KH
authors.lastname: Lam
authors.forename: Chung Hin
authors.initials: CH
authors.lastname: Chui
authors.forename: Roberto
authors.initials: R
authors.lastname: Gambari
authors.forename: Marcus Chun Wah
authors.initials: MC
authors.lastname: Yuen
authors.forename: Raymond Siu Ming
authors.initials: RS
authors.lastname: Wong
authors.forename: Gregory Yin Ming
authors.initials: GY
authors.lastname: Cheng
authors.forename: Fung Yi
authors.initials: FY
authors.lastname: Lau
authors.forename: Yiu Kwok
authors.initials: YK
authors.lastname: Au
authors.forename: Chor Hing
authors.initials: CH
authors.lastname: Cheng
authors.forename: Paul Bo Shan
authors.initials: PB
authors.lastname: Lai
authors.forename: Chi Wai
authors.initials: CW
authors.lastname: Kan
authors.forename: Stanton Hon Lung
authors.initials: SH
authors.lastname: Kok
authors.forename: Johnny Cheuk On
authors.initials: JC
authors.lastname: Tang
authors.forename: Albert Sun Chi
authors.initials: AS
authors.lastname: Chan
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D009369:Neoplasms / Q000473:pathology*; D010797:Phthalimides / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D007659:Ketones; D010797:Phthalimides