Serum levels of MIP-1beta and RANTES in HIV-1 subtype CRF01_AE infected patients with different rates of disease progression.
The beta-chemokines have been shown to inhibit HIV replication in vitro. To evaluate the role of serum beta-chemokines in disease progression and their anti-viral role in vivo, we determined serum levels of macrophage inflammatory protein-1beta (MIP-1beta) and regulated upon activation normal T-cell expressed and secreted (RANTES) of twenty HIV-1 subtype CRF01_AE infected patients: nine progressors (PRs, follow-up CD4+ cell count < 200/mm3 and progression to AIDS or death) and eleven slower progressors (SPs, asymptomatic and/or follow-up CD4+ cell counts > 350/mm3 at the end of follow-up) and determined their plasma viral loads. The subjects were followed for at least 36 months. All had initial CD4 values > 350 cells/mm3. In this longitudinal study, serum levels of MIP-1beta and RANTES in specimens obtained either early or later in the course of HIV infection did not differ significantly between progressors and slower progressors (p > 0.05). There were no significant changes in serum MIP-1beta and RANTES levels over time in either patient group (p > 0.05). No significant associations were observed between plasma viral loads and the measured beta-chemokines (r = -0.205, p = 0.21 for MIP-1beta and r = -0.12, p = 0.492 for RANTES). The results suggest these chemokines do not play a major systemic role in control of viremia or protection against the progression of HIV disease.
Chuenchitra
Thippawan
T
Armed Forces Research Institute of Medical Sciences (AFRIMS), Bangkok, Thailand. ThippawanC@afrims.org
Wasi
Chantapong
C
de Souza
Mark
M
Nitayaphan
Sorachai
S
Louisirirotchanakul
Suda
S
Sutthent
Ruengpung
R
Brown
Arthur E
AE
Birx
Deborah L
DL
Polonis
Victoria R
VR
D018791:CD4 Lymphocyte Count; D054407:Chemokine CCL4 / Q000097:blood*; D018946:Chemokine CCL5 / Q000097:blood*; D018450:Disease Progression; D015658:HIV Infections / Q000097:blood* / Q000503:physiopathology; D015497:HIV-1; D006801:Humans; D012367:RNA, Viral / Q000097:blood; D019562:Viral Load
C066507:CCL4 protein, human; D054407:Chemokine CCL4; D018946:Chemokine CCL5; D012367:RNA, Viral