title: Craniopharyngioma and hypothalamic obesity in children.
abstract: OBJECTIVE
  Obesity is a major concern in children treated for craniopharyngioma and is caused by hypothalamic damage. The role of aggressive surgical removal has been questioned, leading some authors to recommend a minimalist approach. In order to test this hypothesis, we decided to study obesity in craniopharyngioma and the factors related to it.
  
  
  METHODS
  We reviewed retrospectively our series of pediatric craniopharyngiomas operated since 1981. The body-mass index (BMI) was calculated for each patient pre- and at several intervals postoperatively and expressed as standard deviations (SD) adjusted for age and gender.
  
  
  RESULTS
  We operated on 45 cases, which were followed up for a mean duration of 11.0 years. Initial resection was total in 25 cases (55.6%). No patient died because of surgery or tumor progression; two died with delay presumably because of endocrine failure. At last control, 28 patients (62%) had obesity (BMI over +2SD). Hypothalamic involvement was significantly correlated with preoperative and postoperative BMI. Subtotal tumor resection was significantly associated with obesity at last control. Reoperation for tumor recurrence was associated with a significantly higher BMI.
  
  
  CONCLUSIONS
  Our results suggest that obesity results from hypothalamic lesions caused by the tumor rather than by surgery. The postoperative weight gain appears to result from the continued impact of preoperative hypothalamic damage. The high rate of tumor recurrence in children, with the risk of additional damage to the hypothalamus, incites us to recommend total resection whenever it appears safe during initial surgery.
authors.affiliation: Department of Pediatric Neurosurgery, Hospital Roger Salengro, Lille University, Lille, France. m-vinchon@chru-lille.fr
authors.forename: Matthieu
authors.initials: M
authors.lastname: Vinchon
authors.forename: Jacques
authors.initials: J
authors.lastname: Weill
authors.forename: Isabelle
authors.initials: I
authors.lastname: Delestret
authors.forename: Patrick
authors.initials: P
authors.lastname: Dhellemmes
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D003397:Craniopharyngioma / Q000150:complications* / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005602:France; D006801:Humans; D007031:Hypothalamus / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D019635:Neurosurgical Procedures; D009765:Obesity / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D009767:Obesity, Morbid / Q000209:etiology; D010911:Pituitary Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery*; D011183:Postoperative Complications; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D015430:Weight Gain