The Sall2 transcription factor is a novel p75NTR binding protein that promotes the development and function of neurons.
Nerve growth factor (NGF) regulates the functions of neurons by binding the p75 neurotrophin receptor (p75NTR) and TrkA receptors. It is shown here that it has been found that the Sall2 transcription factor forms a complex with p75NTR. NGF dissociates Sall2 from p75NTR and also activates TrkA, which promotes translocation of Sall2 into the nucleus. Nuclear Sall2 activates target genes that modulate the growth and development of neurons. Thus, one way that p75NTR and TrkA can modulate the functions of neurons is by regulating the localization and actions of Sall2.
Pincheira
Roxana
R
The Department of Surgery and the Helen Diller Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA 94115, USA. pincheirar@surgery.ucsf.edu
Donner
David B
DB
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D008954:Models, Biological; D020932:Nerve Growth Factor / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D016716:PC12 Cells; D051381:Rats; D020800:Receptor, Nerve Growth Factor / Q000378:metabolism*; D020917:Receptor, trkA / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism*
D020800:Receptor, Nerve Growth Factor; C535174:Sall2 protein, rat; D014157:Transcription Factors; D020932:Nerve Growth Factor; D020917:Receptor, trkA