[Quantitative approach for calculation of pharmacodynamic interactions and simulation of combined response].
OBJECTIVE
An approach is set up to calculate pharmacodynamic interaction and simulate the combined response.


METHODS
An orthogonal design with 1-level = high dose and 2-level = low dose was adopted. An example of the compound with four components was applied to evaluate this quantitative approach. The bias was evaluated by the both scatter plots.


RESULTS
This approach can calculate the value of each component with different dose by its contribution to combined response, and the value is related to the importance of a compound. Drug interactions were evaluated among the combinations in each group. The prediction model performed well and simulated the combined response in the different of components in combination.


CONCLUSIONS
The approach can be used in the similar research, and it also provides predictions of component combinations from the other studies by simulation.
Chen
Jun-chao
JC
Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Pan
You-jun
YJ
Li
Xing-shan
XS
Sun
Jie
J
Liu
Hong-xia
HX
Sun
Rui-yuan
RY
Zheng
Qing-shan
QS
D000818:Animals; D003198:Computer Simulation; D004347:Drug Interactions; D010600:Pharmacology / Q000379:methods*; D051381:Rats