title: Skeletal muscle ultrasound: correlation between fibrous tissue and echo intensity.
abstract: In this study, we examined the correlation between muscle ultrasound and muscle structure. Echo intensity (EI) of 14 muscles of two golden retriever muscular dystrophy dogs was correlated to the percentage interstitial fibrous tissue and fat in muscle biopsy. A significant correlation between interstitial fibrous tissue and EI was found (r = 0.87; p < 0.001). The separate influence of interstitial fat on muscle EI could not be established as only little fat was present. We conclude that fibrous tissue causes increased muscle EI. The high correlation between interstitial fibrous tissue and EI makes ultrasound a reliable method to determine severity of structural muscle changes.
authors.affiliation: Department of Clinical Neurophysiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. s.pillen@cukz.umcn.nl
authors.forename: Sigrid
authors.initials: S
authors.lastname: Pillen
authors.forename: Ramon O
authors.initials: RO
authors.lastname: Tak
authors.forename: Machiel J
authors.initials: MJ
authors.lastname: Zwarts
authors.forename: Martin M Y
authors.initials: MM
authors.lastname: Lammens
authors.forename: Kiek N
authors.initials: KN
authors.lastname: Verrijp
authors.forename: Ilse M P
authors.initials: IM
authors.lastname: Arts
authors.forename: Jeroen A
authors.initials: JA
authors.lastname: van der Laak
authors.forename: Peter M
authors.initials: PM
authors.lastname: Hoogerbrugge
authors.forename: Baziel G M
authors.initials: BG
authors.lastname: van Engelen
authors.forename: Aad
authors.initials: A
authors.lastname: Verrips
mesh_terms: D000273:Adipose Tissue / Q000000981:diagnostic imaging / Q000473:pathology; D000818:Animals; D001706:Biopsy; D004195:Disease Models, Animal; D004285:Dogs; D005355:Fibrosis / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging* / Q000473:pathology; D009137:Muscular Dystrophy, Animal / Q000000981:diagnostic imaging* / Q000473:pathology; D015203:Reproducibility of Results; D014463:Ultrasonography