The evaluation of mechanical properties of animal tendons after corticosteroid therapy.
The purpose of the study was to examine the effect of systemic glucocorticosteroids administration on mechanical properties of animal tendons. Twenty female Wistar rats were divided into two groups and those that formed experimental group were subjected activity of hydrocortisone given to the peritoneum. Mechanical tests were performed. Hydrocortisone administration caused reduction of force value and the increase of strain, also the value of elasticity module was significantly smaller comparing to the control group. The results of biomechanical tests suggested that glucocorticoids produce less stiffness tendon, which fails in maximum point of load. This study revealed that systemic hydrocortisone administration changes significantly mechanical properties of tendons, which may cause frequent failure of the tendon.
Olchowik
Grazyna
G
Departament of Biophysics, Medical University of Lublin, Lublin, Poland. grazyna.olchowik@am.lublin.pl
Siek
Elzbieta
E
Tomaszewska
Monika
M
Tomaszewski
Marek
M
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001696:Biomechanical Phenomena; D004548:Elasticity; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology*; D006854:Hydrocortisone / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013314:Stress, Mechanical; D013710:Tendons / Q000187:drug effects*
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D006854:Hydrocortisone