title: CIAPIN1 inhibits the growth and proliferation of clear cell renal cell carcinoma.
abstract: Our previous studies indicated a direct correlation with loss of CIAPIN1 and carcinogenesis of tumor in human gastric cancer. Here we presented that the expression of CIAPIN1 was absent or significantly decreased in 102 cases of clear cell renal cell carcinoma (CCRCC) tissues (P<0.05). Up-regulating CIAPIN1 by adenoviral vectors exhibited significant inhibition of CCRCC-derived cell growth in vitro and in vivo with G1 cell cycle arrest. Simultaneously, CIAPIN1-induced growth suppression was found partially to regulate various proteins, including inhibition of cyclinD1, cyclinE, cdk2, cdk4, p-Rb and VEGF, but up-regulation of p27Kip1 and Rb.
authors.affiliation: State Key Laboratory of Cancer Biology & Institute of Digestive Diseases, Xijing Hospital, the Fourth Military Medical University, 17 Changle Western Road, Xi'an 710032, China.
authors.forename: Lijie
authors.initials: L
authors.lastname: He
authors.forename: Hanmin
authors.initials: H
authors.lastname: Wang
authors.forename: Haifeng
authors.initials: H
authors.lastname: Jin
authors.forename: Changcun
authors.initials: C
authors.lastname: Guo
authors.forename: Huahong
authors.initials: H
authors.lastname: Xie
authors.forename: Kun
authors.initials: K
authors.lastname: Yan
authors.forename: Xiaohuai
authors.initials: X
authors.lastname: Li
authors.forename: Qing
authors.initials: Q
authors.lastname: Shen
authors.forename: Taidong
authors.initials: T
authors.lastname: Qiao
authors.forename: Guanglei
authors.initials: G
authors.lastname: Chen
authors.forename: Na
authors.initials: N
authors.lastname: Chai
authors.forename: Lina
authors.initials: L
authors.lastname: Zhao
authors.forename: Qingchuan
authors.initials: Q
authors.lastname: Dong
authors.forename: Yan
authors.initials: Y
authors.lastname: Zheng
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: Daiming
authors.initials: D
authors.lastname: Fan
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D015153:Blotting, Western; D002292:Carcinoma, Renal Cell / Q000235:genetics / Q000378:metabolism*; D049109:Cell Proliferation; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D007680:Kidney Neoplasms / Q000235:genetics / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; C489114:CIAPIN1 protein, human; D047908:Intracellular Signaling Peptides and Proteins