title: Selectivity control in enantioselective four-component reactions of aryl diazoacetates with alcohols, aldehydes and amines: an efficient approach to synthesizing chiral beta-amino-alpha-hydroxyesters.
abstract: Enantioselective four-component reactions of aryl diazoacetates with alcohols, aldehydes and amines catalyzed cooperatively by a rhodium complex and a chiral Brønsted acid produce beta-amino-alpha-hydroxyl acid derivatives in a single step with excellent control of chemo-, diastereo- and enantioselectivity.
authors.affiliation: Department of Chemistry, East China Normal University, Shanghai, 200062, China.
authors.forename: Xinfang
authors.initials: X
authors.lastname: Xu
authors.forename: Jing
authors.initials: J
authors.lastname: Zhou
authors.forename: Liping
authors.initials: L
authors.lastname: Yang
authors.forename: Wenhao
authors.initials: W
authors.lastname: Hu
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D004952:Esters / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D000447:Aldehydes; D000588:Amines; D004952:Esters