title: A new strategy to probe the genotoxicity of silver nanoparticles combined with cetylpyridine bromide.
abstract: The environmental genotoxic behavior of silver nanoparticles (nanoAg) combined with the detergent cetylpyridine bromide (CPB) was examined in vitro. The experimental results showed that the genotoxicity of nanoAg itself is weak, but nanoAg shows obvious genotoxicity after combined with CPB. The combined materials have a strong coeffect on calf thymus DNA (ctDNA) at a concentration of 3.3 x 10(-6 )gmL(-1) nanoAg and 6.0 x 10(-6) molL(-1) CPB. After the addition of ctDNA to the nanoAg-CPB system, the particles are scattered and the diameter decreases, which indirectly reveal that nanoAg-CPB has genotoxicity.
authors.affiliation: School of Environmental Science and Engineering, Shandong University, 27 Shanda South Road, Jinan 250100, PR China.
authors.forename: Zhenxing
authors.initials: Z
authors.lastname: Chi
authors.forename: Rutao
authors.initials: R
authors.lastname: Liu
authors.forename: Lingzi
authors.initials: L
authors.lastname: Zhao
authors.forename: Pengfei
authors.initials: P
authors.lastname: Qin
authors.forename: Xingren
authors.initials: X
authors.lastname: Pan
authors.forename: Feng
authors.initials: F
authors.lastname: Sun
authors.forename: Xiaopeng
authors.initials: X
authors.lastname: Hao
mesh_terms: D000042:Absorption; D000818:Animals; D001965:Bromides / Q000737:chemistry*; D002417:Cattle; D002594:Cetylpyridinium / Q000737:chemistry / Q000633:toxicity*; D004247:DNA / Q000032:analysis / Q000737:chemistry* / Q000648:ultrastructure; D003902:Detergents / Q000737:chemistry / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D008027:Light; D053768:Metal Nanoparticles / Q000737:chemistry / Q000633:toxicity* / Q000648:ultrastructure; D010316:Particle Size; D012542:Scattering, Radiation; D012834:Silver / Q000737:chemistry / Q000633:toxicity; D013056:Spectrophotometry, Ultraviolet
chemical_list: D001965:Bromides; D003902:Detergents; D012834:Silver; D004247:DNA; C427203:calf thymus DNA; D002594:Cetylpyridinium