[Novel therapies of non-revascularizing peripheral arterial occlusive disease: therapeutic angiogenesis].
Critical limb ischemia is the end stage of peripheral arterial occlusive disease, with a deep impact in patient's quality of life. In some patients, there is no revascularizing treatment options, that determines major limb amputation in a high percentage of patients, not only for uncontrolled limb pain but also for complications of the trophic lesions. In the last years, several studies have shown the possibility to increase the perfusion in the ischemic tissue, by recombinant proteins, gene therapy or cellular therapy, all of them known as therapeutic angiogenesis. Several good results have been published but the way of treatment, doses and possible adverse effects still lack definitive conclusions. Randomized comparative studies should be carried out to determine the best treatment option.
Lara-Hernández
Raúl
R
Servicio de Angiología y Cirugía Vascular. Hospital Universitario Arnau de Vilanova. Institut de Recerca Biomédica de Catalunya. Lleida. España. drlarahernandez@yahoo.es
Lozano-Vilardell
Pascual
P
Cordobés-Gual
Jordi
J
D000328:Adult; D000671:Amputation, Surgical; D043925:Angiogenesis Inducing Agents / Q000627:therapeutic use*; D001157:Arterial Occlusive Diseases / Q000628:therapy*; D003097:Collateral Circulation; D018849:Controlled Clinical Trials as Topic; D015444:Exercise; D015316:Genetic Therapy; D006801:Humans; D007383:Intermittent Claudication / Q000628:therapy*; D007511:Ischemia / Q000601:surgery / Q000628:therapy*; D007866:Leg / Q000098:blood supply* / Q000601:surgery; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000628:therapy*; D016032:Randomized Controlled Trials as Topic; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D033581:Stem Cell Transplantation; D013919:Thromboangiitis Obliterans / Q000628:therapy*; D042461:Vascular Endothelial Growth Factor A / Q000627:therapeutic use
D043925:Angiogenesis Inducing Agents; D011994:Recombinant Proteins; D042461:Vascular Endothelial Growth Factor A