title: [Multifocal Abrikossoff's granular cell tumour of the oesophagus--case report].
abstract: BACKGROUND
  Granular cell tumours, relatively uncommon soft tissue tumours, have been a matter of debate among pathologists regarding histogenesis for a long time. Less common locations are in the aerodigestive tract including the oesophagus.
  
  
  METHODS
  We have recently treated a rare case, a 37-year-old male, who was admitted due to dysphagia and a painful swallow with occasional pharyngo-nasal regurgitation followed with a mild loss of weight. Standard clinical examination including X-ray chest, ECG and laboratory tests did not show pathological findings. Barium contrast oesophagography demonstrated multiple ovoid defects in the wall of the oesophagus. CT scan of the chest confirmed luminal narrowing owing to the tumour of the upper oesophagus. Upper endoscopy showed unusual multifocal nodular lesions alongside the oesophageal axis covered by smooth mucosa. A primary biopsy specimen taken from the largest nodules confirmed an unusual pathological finding of the granular cell tumour. Subtotal, transpleural oesophagectomy was performed and reconstruction was derived by long colon segment interposition through the posterior mediastinum. The postoperative course was uneventful. The operative specimen consisted of four ovoid tumours alongside the oesophagus (the greatest diameter 0.5-1.8, average 1.25). All verified tumours histologicaly consisted of a spindle-shaped or polygonal cells containing small and large eosinophilic granules and central nuclei. Most tumour cells showed strongly positive immunohistochemical staining for S-100 protein. These tumour cells were partially positive for p-53 and Ki-67. No lymph node metastases were detected histologically.
  
  
  CONCLUSIONS
  Multifocal granular cell tumour of the oesophagus is an unusual finding with low incidence, and rarely caused symptoms. Pathological features and multiplicity of such tumours emphasized malignant predisposition requiring surgical resection of the oesophagus.
authors.forename: Tomislav D
authors.initials: TD
authors.lastname: Randjelović
authors.forename: Zorica M
authors.initials: ZM
authors.lastname: Stojsić
authors.forename: Jasna M
authors.initials: JM
authors.lastname: Gacić
authors.forename: Darko N
authors.initials: DN
authors.lastname: Babić
authors.forename: Miodrag T
authors.initials: MT
authors.lastname: Stojiljković
authors.forename: Ivanka M
authors.initials: IM
authors.lastname: Baralić
authors.forename: Miroslav K
authors.initials: MK
authors.lastname: Granić
authors.forename: Nebojsa S
authors.initials: NS
authors.lastname: Ivanović
authors.forename: Dragan M
authors.initials: DM
authors.lastname: Gacić
mesh_terms: D000328:Adult; D004938:Esophageal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D016586:Granular Cell Tumor / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000473:pathology