Enantioselective iridium-catalyzed allylic arylation.
We describe herein the development of the first iridium-catalyzed allylic substitution using arylzinc nucleophiles. High enantioselectivities were obtained from the reactions, which used commercially available Grignard reagents as the starting materials. This methodology was also shown to be compatible with halogen/metal exchange reactions. Its synthetic potential is demonstrated by its application towards the formal synthesis of (+)-sertraline.
Polet
Damien
D
Department of Organic Chemistry, University of Geneva, 30 quai Ernest Ansermet, 1211 Genève 4, Switzerland.
Rathgeb
Xavier
X
Falciola
Caroline A
CA
Langlois
Jean-Baptiste
JB
El Hajjaji
Samir
S
Alexakis
Alexandre
A