Selectivity control in enantioselective four-component reactions of aryl diazoacetates with alcohols, aldehydes and amines: an efficient approach to synthesizing chiral beta-amino-alpha-hydroxyesters.
Enantioselective four-component reactions of aryl diazoacetates with alcohols, aldehydes and amines catalyzed cooperatively by a rhodium complex and a chiral Brønsted acid produce beta-amino-alpha-hydroxyl acid derivatives in a single step with excellent control of chemo-, diastereo- and enantioselectivity.
Xu
Xinfang
X
Department of Chemistry, East China Normal University, Shanghai, 200062, China.
Zhou
Jing
J
Yang
Liping
L
Hu
Wenhao
W
D000438:Alcohols / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D004952:Esters / Q000737:chemistry*; D013237:Stereoisomerism
D000438:Alcohols; D000447:Aldehydes; D000588:Amines; D004952:Esters