The molecular cascades of long-term potentiation underlie memory consolidation of one-trial avoidance in the CA1 region of the dorsal hippocampus, but not in the basolateral amygdala or the neocortex.
Data accumulated through the past 15 years showed that memory consolidation of one-trial avoidance learning relies on a sequence of molecular events in the CA1 region of the hippocampus that is practically identical to that of long-term potentiation (LTP) in that area. Recent findings have indeed described CA1 LTP concomitant to the consolidation of this and other tasks. However, abundant evidence suggests that, in addition, other molecular events, involving some of the same steps but with different timing and in different sequence in the basolateral amygdala, entorhinal, parietal and cingulate cortex are as important as those of the hippocampus for memory consolidation. Here we review the hippocampal mechanisms involved and the possible interconnections between all these processes. Overall, the findings indicate that memory consolidation of even a task as deceivingly simple as one-trial avoidance relies on hippocampal LTP but also requires the concomitant participation of other brain systems and molecular events. Further, they point to the mechanisms that account for the enhanced consolidation usually seen for emotion-laden memories.
Izquierdo
Iván
I
Centro de Memoria, Instituto de Pesquisas Biomédicas, Pontificia Universidade Católica de Rio Grande do Sul, Hospital Sao Lucas, Porto Alegre, RS, Brazil. Ivan.izquierdo@pucrs.br
Bevilaqua
Lia R M
LR
Rossato
Janine I
JI
da Silva
Weber C
WC
Bonini
Juliana
J
Medina
Jorge H
JH
Cammarota
Martín
M
D000679:Amygdala / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects* / Q000502:physiology*; D004644:Emotions; D018728:Entorhinal Cortex / Q000187:drug effects / Q000502:physiology; D006179:Gyrus Cinguli / Q000187:drug effects / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology; D017774:Long-Term Potentiation / Q000187:drug effects* / Q000502:physiology*; D008568:Memory / Q000187:drug effects* / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000494:pharmacology; D010296:Parietal Lobe / Q000187:drug effects / Q000502:physiology; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D051381:Rats; D015398:Signal Transduction / Q000187:drug effects
D018377:Neurotransmitter Agents; D011500:Protein Synthesis Inhibitors