[Development of oxidative stress in complicated pregnancy].
The changes in the blood activity of antioxidative defense system enzymes were evaluated in pregnant and non-pregnant women with arterial hypertension (AH). The directionality of revealed changes may be regarded ambiguously. Specifically, the detected dysregulation of first-line antioxidative defense enzymes leads to the accumulation of different forms of active oxygen metabolites that are involved in the development of the molecular basis of the pathogenesis of AH. However, activation of peroxidation processes not only ensures the molecular mechanism of cellular damage, but also aims at developing compensatory and adaptive reactions. The degree of these impairments is likely to be affected by the influence of oxidative stress starting from the cell to organism level--the formation of a metabolic compensation or decompensation phase in arterial hypertension.
Olempieva
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EV
Mikashinovich
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ZI
D016022:Case-Control Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000201:enzymology / Q000378:metabolism*; D008054:Lipid Peroxides / Q000097:blood; D018384:Oxidative Stress; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood / Q000201:enzymology / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000097:blood; D013482:Superoxide Dismutase / Q000097:blood
D008054:Lipid Peroxides; D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase