Increased risk of zoonotic Salmonella and Campylobacter gastroenteritis in patients with haematological malignancies: a population-based study.
We hypothesised that haematological malignancies increase the risk of acquiring zoonotic Salmonella or Campylobacter gastroenteritis. The population-based study comprised all first-time Salmonella/Campylobacter gastroenteritis cases in two Danish counties (1991-2003), with age- and gender-matched controls from the background population. We linked the study cohort to registries to obtain data on malignancies, chemotherapy (yes/no), and main comorbidities diagnosed before Salmonella/Campylobacter gastroenteritis. Based on this design, we determined incidence rate ratios (IRR) in conditional logistic regression analyses, and we used weighted mean regression curves to evaluate fluctuations in risk 0-5 years after the malignancy diagnosis. Sixty-eight of 13,324 cases (0.5%) and 29 of 26,648 controls (0.1%) had haematological malignancy before their Salmonella/Campylobacter gastroenteritis. Comorbidity-adjusted IRR for Salmonella/Campylobacter gastroenteritis in patients with haematological malignancy as compared to patients without malignancy were 4.46 [95% confidence intervals (CI), 2.88-6.90] for all individuals, 8.33 (95% CI, 4.31-16.1) for Salmonella, and 2.17 (95% CI, 1.15-4.08) for Campylobacter. Stratification on chemotherapy treatment did not change these estimates. In time-related analyses, IRR were 7-8 in the first 2 years after the haematological malignancy diagnosis and 4-5 in the following 3 years. Patients with haematological malignancy had increased long-term risk of enquiring Salmonella or Campylobacter gastroenteritis.
Gradel
Kim O
KO
Department of Infectious Diseases, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark. kog@rn.dk
Nørgaard
Mette
M
Dethlefsen
Claus
C
Schønheyder
Henrik C
HC
Kristensen
Brian
B
Ejlertsen
Tove
T
Nielsen
Henrik
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D002169:Campylobacter Infections / Q000453:epidemiology / Q000209:etiology*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003718:Denmark / Q000453:epidemiology; D004198:Disease Susceptibility; D005260:Female; D005759:Gastroenteritis / Q000453:epidemiology / Q000209:etiology* / Q000382:microbiology; D019337:Hematologic Neoplasms / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections; D012042:Registries; D012043:Regression, Psychology; D012306:Risk; D012480:Salmonella Infections / Q000453:epidemiology / Q000209:etiology*; D055815:Young Adult; D015047:Zoonoses
D000970:Antineoplastic Agents