[Case of fulminant hepatic failure in an elderly asymptomatic HBV carrier without proximate cause].
A 82-year-old asymptomatic HBV carrier man was admitted with liver dysfunction in May 2007. With anti-HBe antibody and high viral load, he had fulminant hepatic failure without proximate cause. He was treated with entecavir and corticosteroids, but died about one month later. Autopsy specimen of liver revealed submassive hepatic necrosis with faint regeneration. HBV obtained was segregated into genotype Bj, and mutation was detected at nt1896 in a precore region.
Yamamoto
Takeshi
T
Department of Gastroenterology, Tohoku Kosei-Nenkin Hospital.
Kondo
Shiho
S
Sugawara
Akiko
A
Yonechi
Makoto
M
Nishioka
Kana
K
Meguro
Takayoshi
T
Abe
Masahide
M
Murakami
Kazuhiro
K
Inoue
Jun
J
Ueno
Yoshiyuki
Y
Shimosegawa
Toru
T
D000369:Aged, 80 and over; D002353:Carrier State; D017809:Fatal Outcome; D005838:Genotype; D006509:Hepatitis B / Q000188:drug therapy / Q000473:pathology / Q000821:virology; D006515:Hepatitis B virus / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D008099:Liver / Q000473:pathology / Q000821:virology; D017114:Liver Failure, Acute / Q000188:drug therapy / Q000473:pathology / Q000821:virology*; D008297:Male; D009154:Mutation; D009336:Necrosis