Gout in the transplant patient.
Patients treated with cyclosporine after organ transplantation are at particular risk for the development of hyperuricemia and tophaceous gout. The appearance of tophi or clinical gout can occur within a short time of initiation of cyclosporine therapy. Treatment decisions for the often accelerated and severe gouty arthritis must take into consideration numerous drug interactions as well as the degree of allograft dysfunction, or renal insufficiency due to the effects of disease or medication.
George
T
T
Department of Rheumatic and Immunologic Diseases, Cleveland Clinic Foundation, Cleveland, Ohio.
Mandell
B F
BF