The detrimental effect of poor early graft function after laparoscopic live donor nephrectomy on graft outcomes.
We undertook this study to assess the rate of poor early graft function (EGF) after laparoscopic live donor nephrectomy (lapNx) and to determine whether poor EGF is associated with diminished long-term graft survival. The study population consisted of 946 consecutive lapNx donors/recipient pairs at our center. Poor EGF was defined as receiving hemodialysis on postoperative day (POD) 1 through POD 7 (delayed graft function [DGF]) or serum creatinine >/= 3.0 mg/dL at POD 5 without need for hemodialysis (slow graft function [SGF]). The incidence of poor EGF was 16.3% (DGF 5.8%, SGF 10.5%), and it was stable in chronologic tertiles. Poor EGF was independently associated with worse death-censored graft survival (adjusted hazard ratio (HR) 2.15, 95% confidence interval (CI) 1.34-3.47, p = 0.001), worse overall graft survival (HR 1.62, 95% CI 1.10-2.37, p = 0.014), worse acute rejection-free survival (HR 2.75, 95% CI 1.92-3.94, p < 0.001) and worse 1-year renal function (p = 0.002). Even SGF independently predicted worse renal allograft survival (HR 2.54, 95% CI 1.44-4.44, p = 0.001). Risk factors for poor DGF included advanced donor age, high recipient BMI, sirolimus use and prolonged warm ischemia time. In conclusion, poor EGF following lapNx has a deleterious effect on long-term graft function and survival.
Nogueira
J M
JM
Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. jnogueir@medicine.umaryland.edu
Haririan
A
A
Jacobs
S C
SC
Weir
M R
MR
Hurley
H A
HA
Al-Qudah
H S
HS
Phelan
M
M
Drachenberg
C B
CB
Bartlett
S T
ST
Cooper
M
M
D000328:Adult; D015992:Body Mass Index; D015331:Cohort Studies; D003404:Creatinine / Q000097:blood; D051799:Delayed Graft Function / Q000503:physiopathology*; D005260:Female; D006084:Graft Rejection / Q000175:diagnosis / Q000453:epidemiology*; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D015994:Incidence; D007668:Kidney / Q000503:physiopathology*; D016030:Kidney Transplantation / Q000502:physiology*; D010535:Laparoscopy; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D011183:Postoperative Complications; D006435:Renal Dialysis; D012307:Risk Factors; D020858:Tissue and Organ Harvesting; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D052096:Warm Ischemia
D003404:Creatinine