Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ.
3-Methoxybenzamide is a weak inhibitor of the essential bacterial cell division protein FtsZ. Exploration of the structure-activity relationships of 3-methoxybenzamide analogues led to the identification of potent anti-staphylococcal compounds.
Czaplewski
Lloyd G
LG
Prolysis Ltd, Begbroke Science Park, Sandy Lane, Yarnton, Oxfordshire OX5 1PF, UK.
Collins
Ian
I
Boyd
E Andrew
EA
Brown
David
D
East
Stephen P
SP
Gardiner
Mihaly
M
Fletcher
Rowena
R
Haydon
David J
DJ
Henstock
Vincent
V
Ingram
Peter
P
Jones
Clare
C
Noula
Caterina
C
Kennison
Leanne
L
Rockley
Chris
C
Rose
Valerie
V
Thomaides-Brears
Helena B
HB
Ure
Rebecca
R
Whittaker
Mark
M
Stokes
Neil R
NR
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors*; D001549:Benzamides / Q000737:chemistry / Q000494:pharmacology*; D003598:Cytoskeletal Proteins / Q000037:antagonists & inhibitors*; D008826:Microbial Sensitivity Tests; D013210:Staphylococcus / Q000187:drug effects*; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D001549:Benzamides; D003598:Cytoskeletal Proteins; C071525:FtsZ protein, Bacteria; C025159:3-methoxybenzamide