Epi-perineurial anatomy, innervation, and axonal nociceptive mechanisms.
Nerves are usually viewed as simple conduits of electrical signals to make muscles move and enable sensation. However, recent data have shown that the axons within nerves are capable of responding to their environment. Nerves have a very specialized anatomy and physiology, and are capable of mediating certain types of pain. This synopsis introduces the reader to these concepts, which can be incorporated into clinical decision-making.
Bove
Geoffrey M
GM
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 01907, USA. gbove@bidmc.harvard.edu
D000818:Animals; D001369:Axons / Q000502:physiology; D005205:Fascia / Q000294:innervation*; D006801:Humans; D009619:Nociceptors / Q000502:physiology*; D010146:Pain / Q000503:physiopathology*; D010525:Peripheral Nerves / Q000033:anatomy & histology* / Q000502:physiology*