title: A novel and convenient protocol for synthesis of pyridazines.
abstract: A new flexible strategy for the synthesis of diversely functionalized pyridazines from 4-chloro-1,2-diaza-1,3-butadienes and active methylene compounds is reported. The high chemoselectivity of this approach offers access to structural precursors of GABA-A antagonist analogues.
authors.affiliation: Istituto di Chimica Organica, Universita degli Studi di Urbino Carlo Bo, Via I Maggetti 24, 61029 Urbino, Italy.
authors.forename: Orazio A
authors.initials: OA
authors.lastname: Attanasi
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Favi
authors.forename: Paolino
authors.initials: P
authors.lastname: Filippone
authors.forename: Francesca R
authors.initials: FR
authors.lastname: Perrulli
authors.forename: Stefania
authors.initials: S
authors.lastname: Santeusanio
mesh_terms: D002070:Butadienes / Q000737:chemistry; D018756:GABA Antagonists / Q000138:chemical synthesis* / Q000737:chemistry; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry; D013379:Substrate Specificity
chemical_list: D002070:Butadienes; D018756:GABA Antagonists; D011724:Pyridazines; C513630:aminopyridazine; C062482:pyridazine