Syntheses and biological activities of fluorescent-labeled analogs of acylpolyamine toxin NPTX-594 isolated from the venom of Madagascar Joro spider.
Acylpolyamine-type spider toxins are known to be potent and specific blockers against glutamate receptors (GluRs). The present study describes the syntheses and biological activities of several fluorescent-labeled analogs related to a Madagascar Joro spider toxin NPTX-594 to analyze visually the unknown interaction between spider toxins and GluRs.
Nishimaru
Takahiro
T
Faculty of Science and Technology, Kinki University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan.
Sano
Masako
M
Yamaguchi
Yoshihiro
Y
Wakamiya
Tateaki
T
D000818:Animals; D018691:Excitatory Amino Acid Antagonists / Q000138:chemical synthesis*; D005456:Fluorescent Dyes; D011073:Polyamines / Q000138:chemical synthesis* / Q000494:pharmacology; D017470:Receptors, Glutamate / Q000187:drug effects; D013111:Spider Venoms / Q000138:chemical synthesis* / Q000494:pharmacology
D018691:Excitatory Amino Acid Antagonists; D005456:Fluorescent Dyes; C044936:JSTX spider toxin; D011073:Polyamines; D017470:Receptors, Glutamate; D013111:Spider Venoms