Six cases of Aerococcus sanguinicola infection: clinical relevance and bacterial identification.
Aerococcus sanguinicola is a Gram-positive coccus first described in 2001. Infections in humans are rare but the use of 16S rRNA gene sequencing and improved phenotypic methods has facilitated the identification of A. sanguinicola. We report here 6 cases of A. sanguinicola bacteraemia, 2 of which were associated with infective endocarditis. Most patients were elderly (median age 70 y) and had underlying neurological disorders including dementia, cerebral degeneration, and myelomeningocele. The primary focus of infection was the urinary tract in 3 cases and the gallbladder in 1; no focus was detected in 2 cases. Long-term prognosis was poor reflecting the frailty of the patients. All strains were susceptible to penicillin, ampicillin, cefuroxime, vancomycin, erythromycin, and rifampicin. The optimal treatment of infection with A. sanguinicola has yet to be determined.
Ibler
Kristina
K
Department of Bacteriology, Mycology and Parasitology, Statens Serum Institute, Copenhagen, Denmark. Kristinaibler@hotmail.com
Truberg Jensen
Kjeld
K
Ostergaard
Christian
C
Sönksen
Ute Wolff
UW
Bruun
Brita
B
Schønheyder
Henrik C
HC
Kemp
Michael
M
Dargis
Rimtas
R
Andresen
Keld
K
Christensen
Jens Jørgen
JJ
D000328:Adult; D000368:Aged; D016470:Bacteremia / Q000382:microbiology / Q000503:physiopathology; D003718:Denmark / Q000453:epidemiology; D004697:Endocarditis, Bacterial / Q000382:microbiology; D005260:Female; D005705:Gallbladder Diseases / Q000382:microbiology; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D017422:Sequence Analysis, DNA; D013289:Streptococcaceae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity; D014552:Urinary Tract Infections / Q000382:microbiology
D012336:RNA, Ribosomal, 16S