Sensitive determination of dopamine and uric acid by the use of a glassy carbon electrode modified with poly(3-methylthiophene)/gold nanoparticle composites.
A kind of novel nanocomposites, poly(3-methylthiophene) (P3MT)/gold nanoparticles (AuNPs), were successfully deposited onto the surface of a glassy carbon electrode. A field emission scanning electron microscope (FE-SEM) and electrochemical techniques were used for characterizing this modified electrode. The results showed that the AuNPs were inserted into a P3MT layer uniformly, and formed a porous 3D structure. This modified electrode showed excellent electrocatalytic activity towards the oxidation of ascorbic acid (AA), dopamine (DA) and uric acid (UA); the overlapping anodic peaks of AA, DA and UA were completely divided into three well-defined voltammetric peaks. A further study showed that there existed a linear relationship between the peak current and the concentration of DA in the range of 1.0 x 10(-6) to 3.5 x 10(-5) mol L(-1), and UA in the range of 1.0 x 10(-6) to 3.2 x 10(-5) mol L(-1). The detection limits were 2.4 x 10(-7) mol L(-1) for DA and 1.7 x 10(-7) mol L(-1) for UA. This proposed method was applied to the detection of real samples, and the results were satisfactory.
Huang
Xue
X
Anhui Key Laboratory of Chemo-Biosensing, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, P. R. China.
Li
Yongxin
Y
Wang
Po
P
Wang
Lun
L
D001205:Ascorbic Acid / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D004298:Dopamine / Q000032:analysis* / Q000737:chemistry / Q000652:urine; D017097:Electric Impedance; D004563:Electrochemistry; D004566:Electrodes; D005898:Glass / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D053768:Metal Nanoparticles / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D053761:Nanocomposites / Q000737:chemistry*; D010084:Oxidation-Reduction; D011108:Polymers / Q000737:chemistry*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013499:Surface Properties; D013876:Thiophenes / Q000737:chemistry*; D014527:Uric Acid / Q000032:analysis* / Q000737:chemistry / Q000652:urine
D011108:Polymers; D013876:Thiophenes; D014527:Uric Acid; D002244:Carbon; D006046:Gold; C062788:poly(3-methylthiophene); D001205:Ascorbic Acid; D004298:Dopamine