Hedgehog signaling in development and cancer.
The Hedgehog (Hh) family of secreted proteins governs a wide variety of processes during embryonic development and adult tissue homeostasis. Here we review the current understanding of the molecular and cellular basis of Hh morphogen gradient formation and signal transduction, and the multifaceted roles of Hh signaling in development and tumorigenesis. We discuss how the Hh pathway has diverged during evolution and how it integrates with other signaling pathways to control cell growth and patterning.
Jiang
Jin
J
Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA. jin.jiang@utsouthwestern.edu
Hui
Chi-Chung
CC
D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D004330:Drosophila; D018507:Gene Expression Regulation, Developmental; D015972:Gene Expression Regulation, Neoplastic; D053823:Hedgehog Proteins / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology
D053823:Hedgehog Proteins