title: Expression of Frizzled10 in mouse central nervous system.
abstract: Frizzled transmembrane proteins (Fzd) are receptors of Wnts, and they play key roles during central nervous system (CNS) development in vertebrates. Here we report the expression pattern of Frizzled10 in mouse CNS from embryonic stages to adulthood. Frizzled10 is expressed strongly at embryonic days E8.5 and E9.5 in the neural tube and tail bud. At E10.5, Frizzled10 is expressed in the forebrain vesicle, the fourth ventricle and the dorsal spinal cord. From E12.5 to E16.5, Frizzled10 expression is mainly observed in the cortical hem/fimbria, the neuroepithelium of the third ventricular zone, midbrain, developing cerebellum, and dorsal spinal cord. At P0, with the exception of expression in the fimbria, Frizzled10 mRNA expression is limited to specific nuclei including the ventral posterior thalamic nucleus (VP) and the dorsal lateral geniculate nucleus (DLG) in the developing thalamus as well as in the proliferative ventricular zone of the developing cerebellum. From P20 to adult, Frizzled10 mRNA is detected only in the internal capsule (ic). Our data show that expression of Frizzled10 is very strong during embryonic development of the CNS and suggest that Frizzled10 may play an essential role in spatial and temporal regulation during neural development.
authors.affiliation: Key Laboratory of Developmental Genes and Human Diseases, MOE, School of Medicine, Southeast University, 87 Dingjiaoqiao Road, Nanjing, Jiangsu, 210009, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yan
authors.forename: Yiping
authors.initials: Y
authors.lastname: Li
authors.forename: Chuanyin
authors.initials: C
authors.lastname: Hu
authors.forename: Xiaochun
authors.initials: X
authors.lastname: Gu
authors.forename: Junhua
authors.initials: J
authors.lastname: Liu
authors.forename: Yu-An
authors.initials: YA
authors.lastname: Hu
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.forename: Yiquan
authors.initials: Y
authors.lastname: Wei
authors.forename: Chunjie
authors.initials: C
authors.lastname: Zhao
mesh_terms: D000818:Animals; D004027:Diencephalon / Q000196:embryology / Q000378:metabolism; D051157:Frizzled Receptors / Q000096:biosynthesis / Q000235:genetics; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D018878:Limb Buds / Q000378:metabolism; D008636:Mesencephalon / Q000196:embryology / Q000378:metabolism; D051379:Mice; D054259:Neural Tube / Q000196:embryology / Q000378:metabolism; D055495:Neurogenesis / Q000235:genetics*; D043562:Receptors, G-Protein-Coupled / Q000096:biosynthesis / Q000235:genetics; D012249:Rhombencephalon / Q000196:embryology / Q000378:metabolism; D013116:Spinal Cord / Q000196:embryology / Q000378:metabolism; D013687:Telencephalon / Q000196:embryology / Q000378:metabolism
chemical_list: D051157:Frizzled Receptors; C492388:Fzd10 protein, mouse; D043562:Receptors, G-Protein-Coupled