Aspernolides A and B, butenolides from a marine-derived fungus Aspergillus terreus.
Two aromatic butenolides, aspernolides A and B along with the known metabolites, butyrolactone I, terrein and physcion were isolated from the fermentation broth of a soft coral derived fungus Aspergillus terreus. The structures of these metabolites were assigned on the basis of detailed spectroscopic analysis. The absolute stereochemistry of aspernolides A (1) and B (2) was established by their preparation from the known butyrolactone I. Biogenetically aspernolides A and B must be derived from butyrolactone I, a well known specific inhibitor of cyclin dependent kinase (cdk) from A. terreus. When tested, aspernolide A exhibited mild cytotoxicity against cancer cell lines.
Parvatkar
Rajesh R
RR
Bioorganic Chemistry Laboratory, National Institute of Oceanography, Council of Scientific and Industrial Research (CSIR), Dona Paula, Goa 403 004, India. parvatkar@gmail.com
D'Souza
Celina
C
Tripathi
Ashootosh
A
Naik
Chandrakant G
CG
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry; D001230:Aspergillus / Q000737:chemistry* / Q000378:metabolism*; D008967:Molecular Biology
C540299:aspernolide A; C540301:aspernolide B; D015107:4-Butyrolactone