The PRMT1 gene expression pattern in colon cancer.
The methylation of arginine has been implicated in many cellular processes, such as regulation of transcription, mRNA splicing, RNA metabolism and transport. The enzymes responsible for this modification are the protein arginine methyltransferases. The most abundant methyltransferase in human cells is protein arginine methyltransferase 1. Methylation processes appear to interfere in the emergence of several diseases, including cancer. During our study, we examined the expression pattern of protein arginine methyltransferase 1 gene in colon cancer patients. The emerging results showed that the expression of one of the gene variants is associated with statistical significant probability to clinical and histological parameters, such as nodal status and stage. This is a first attempt to acquire an insight on the possible relation of the expression pattern of protein arginine methyltransferase 1 and colon cancer progression.
Mathioudaki
K
K
Department of Cellular Physiology, 'G Papanicolaou' Research Center of Oncology, 'Saint Savvas' Hospital, 171 Alexandras Avenue, Athens 11522, Greece.
Papadokostopoulou
A
A
Scorilas
A
A
Xynopoulos
D
D
Agnanti
N
N
Talieri
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D003110:Colonic Neoplasms / Q000201:enzymology* / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D018076:DNA, Complementary / Q000235:genetics; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D011484:Protein-Arginine N-Methyltransferases / Q000235:genetics* / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics* / Q000378:metabolism
D018076:DNA, Complementary; D012097:Repressor Proteins; C099988:PRMT1 protein, human; D011484:Protein-Arginine N-Methyltransferases