title: Adequacy of endoscopic ultrasound core needle biopsy specimen of nonmalignant hepatic parenchymal disease.
abstract: OBJECTIVE
  The adequacy and diagnostic yield of hepatic parenchymal disease Trucut biopsy have not been determined. Therefore, our aim was to determine the adequacy of endoscopic ultrasound (EUS)-guided Trucut liver biopsy for histopathologic evaluation to include the number of complete portal tracts contained per millimeter of acquired tissue.
  
  
  METHODS
  A single institution retrospective review was made of 9 prospectively identified patients who underwent a transgastric left liver lobe EUS-guided Trucut biopsy during a 36-month period.
  
  
  RESULTS
  Adequate diagnostic material, to include complete portal tract number evaluation (median, 7) and connective tissue staining, was acquired to establish a histopathologic diagnosis in all 9 cases. Sixty-three complete portal tracts were established, resulting in 0.4 portal tracts per millimeter of tissue acquired. Findings established by EUS Trucut left liver lobe biopsy included mild steatosis (n = 4), cryptogenic cirrhosis (n = 2), chronic ductopenic biliary tract disease (n = 1), portal fibrosis with ductular proliferation (n = 1), and alcoholic cirrhosis with hemosiderosis (n = 1).
  
  
  CONCLUSIONS
  EUS-guided Trucut left liver lobe biopsy yields suitable aggregate tissue for diagnostic purposes to establish the presence of chronic liver disease.
authors.affiliation: Fiterman Centre for Digestive Disease, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
authors.forename: Ferga C
authors.initials: FC
authors.lastname: Gleeson
authors.forename: Amy C
authors.initials: AC
authors.lastname: Clayton
authors.forename: Lizhi
authors.initials: L
authors.lastname: Zhang
authors.forename: Jonathan E
authors.initials: JE
authors.lastname: Clain
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Gores
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Rajan
authors.forename: Tom C
authors.initials: TC
authors.lastname: Smyrk
authors.forename: Mark D
authors.initials: MD
authors.lastname: Topazian
authors.forename: Kenneth K
authors.initials: KK
authors.lastname: Wang
authors.forename: Maurits J
authors.initials: MJ
authors.lastname: Wiersema
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Levy
mesh_terms: D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D019160:Endosonography; D005260:Female; D006302:Health Services Research; D006801:Humans; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged