Defining and reporting erectile function outcomes after radical prostatectomy: challenges and misconceptions.
OBJECTIVE
The contemporary literature pertaining to erectile dysfunction after radical prostatectomy was evaluated. The limitations of this literature are discussed and recommendations are made for the reporting of erectile function outcomes after radical prostatectomy.


METHODS
A MEDLINE literature search was conducted in February 2008 to review English language articles published on this subject from 2000 onward. The key elements in defining and reporting erectile function outcomes after radical prostatectomy that were explored included 1) study population factors, 2) population demographics, 3) means of data acquisition, 4) variability in questionnaire use, 5) temporal considerations, 6) baseline erectile function status, 7) defining adequate erectile function, and the concepts of 8) quality and 9) consistency of erection.


RESULTS
The incidence of reported erectile dysfunction after radical prostatectomy is extremely discrepant. The rates of erectile dysfunction appear to be higher in multicenter, multisurgeon series compared to single center, single surgeon series. A total of 24 articles were culled from the literature, which are believed to be representative of the literature in this area. There was great variation in the nature of the populations studied, how data were acquired and reported, and how baseline and postoperative adequate erectile function was defined.


CONCLUSIONS
This review studies the strengths and weaknesses of the literature on erectile dysfunction after radical prostatectomy, and makes some general recommendations for investigating and reporting erectile function outcomes after radical prostatectomy.
Mulhall
John P
JP
Sexual and Reproductive Medicine Program, Urology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA. mulhalj1@mskcc.org
D000368:Aged; D007172:Erectile Dysfunction / Q000453:epidemiology* / Q000209:etiology* / Q000503:physiopathology; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011468:Prostatectomy / Q000009:adverse effects* / Q000379:methods*; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000601:surgery; D018570:Risk Assessment; D012680:Sensitivity and Specificity