Frequency of FLT3 mutations in childhood acute lymphoblastic leukemia.
FLT3 mutations are occasionally observed in acute lymphoblastic leukemia (ALL). These most frequently manifest as internal tandem duplications (ITD) and activation loop (AL) mutations. This study investigated the incidence of FLT3 mutations in 86 pediatric patients diagnosed with ALL and the co-presence of common RAS mutations. A 2.3% (2/86) FLT3/AL mutation rate in terms of total ALL cases and a 22% (2/9) incidence in hyperdiploid cases was observed. This is in accordance to previous studies indicating a higher incidence in the patient subgroup associated with hyperdiploidy.
Braoudaki
M
M
Hematology/Oncology Unit, First Department of Pediatrics, University of Athens, Aghia Sophia Children's Hospital, Thivon & Levadias, Goudi-Athens, 11527 Athens, Greece. mbraouda@yahoo.co.uk
Karpusas
M
M
Katsibardi
K
K
Papathanassiou
Ch
Ch
Karamolegou
K
K
Tzortzatou-Stathopoulou
F
F
D002648:Child; D006801:Humans; D015994:Incidence; D009154:Mutation / Q000235:genetics*; D011123:Polyploidy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D011379:Prognosis; D051941:fms-Like Tyrosine Kinase 3 / Q000235:genetics*
C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3