[Comparative analysis of 1-desamino-arginine-vasotocin, 1-desamino-1-monocarba-arginine-vasotocin and desmopressin antidiuretic effect in rats].
This study was carried out to investigate the antidiuretic efficacy of 1-desamino-arginine-vasotocin (1-dAVT), 1-desamino-1-monocarba-arginine-vasotocin (1-dlmcAVT) in comparison with desmopressin in Wistar rats. Intramuscular injection of 0.0001 nmole/100 g body weight of desmopressin or synthesized analogues of arginine-vasotocin 5 % in the water loading resulted in significant reduction of urinary flow (p < 0.001) and later removed the diuresis maximum. The most expressed decrease of water excretion which was correlated with the diminished diuresis (r = -0.78,p < 0.001) was observed after injection of 0.0001 nmole/100 g body weight desmopressin. The equivalent increase of water reabsorbtion was induced by 0.00005 nmole/100 g body weight 1-dlmcAVT or desmopressin. The differences between excretion of osmotically active substances, sodium or potassium in the action of 1-dAVT, 1 -d-lmcAVT and desmopressin was not revealed.
Bogolepova
A E
AE
Zaĭtseva
K V
KV
D000818:Animals; D050034:Antidiuretic Agents / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology*; D005260:Female; D010120:Oxytocics / Q000494:pharmacology; D011188:Potassium / Q000652:urine; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000652:urine; D014668:Vasotocin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D014867:Water / Q000378:metabolism; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D050034:Antidiuretic Agents; D010120:Oxytocics; D014867:Water; D012964:Sodium; D003894:Deamino Arginine Vasopressin; D011188:Potassium; D014668:Vasotocin