title: Primary multiple extragastrointestinal stromal tumors of the omentum with different mutations of c-kit gene.
abstract: The author reports a very rare case of sporadic primary multiple extragastrointestinal stromal tumors (EGISTs) of the omentum associated with different mutations of the exon 11 of the c-kit gene in a 75-year-old man with gastric cancer. During an operation for the cancer, two solid tumors (10 mm and 8 mm) were found in the omentum. Both tumors consisted of cellular spindle cells. Mitotic figures were two and three per 50 high power fields. The tumor cells were positive for KIT, CD34 and vimentin, but negative for desmin, S100 protein, alpha-smooth muscle actin and p53 protein. Ki67 labeling was 2% and 3%. The larger EGIST showed a deletion of codons 552-558 of exon 11 of the c-kit gene, while the smaller EGIST had a point mutation at codon 559 (GTT-->GAT) in exon 11 of the c-kit gene. Exons 9, 13, and 17 of the c-kit gene, and exons 12 and 18 of the platelet derived growth factor receptor alpha genes showed no mutations. The case shows that sporadic multiple EGISTs can occur in the omentum.
authors.affiliation: Department of Pathology, Shizuoka Municipal Shimizu Hospital, Miyakami 1231, Shimizu-Ku, 424-8636, Shizuoka, Japan. piyo0111jp@yahoo.co.jp
authors.forename: Tadashi
authors.initials: T
authors.lastname: Terada
mesh_terms: D000368:Aged; D005091:Exons; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis / Q000235:genetics*; D017353:Gene Deletion; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics*; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000235:genetics*; D009852:Omentum; D010534:Peritoneal Neoplasms / Q000175:diagnosis / Q000235:genetics*; D017354:Point Mutation / Q000235:genetics; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics*
chemical_list: D019009:Proto-Oncogene Proteins c-kit