Risk factors for cardiovascular disease and endothelin-1 levels in Takayasu arteritis patients.
The objective of this study was to evaluate traditional risk factors for cardiovascular disease (CVD) and endothelin-1 (ET-1) levels in Takayasu arteritis (TA) patients. Twenty-two TA patients and 37 controls were evaluated. TA patients had a higher prevalence of hypertension (63.6% vs. 21.6%, p=0.001) and higher levels of triglycerides (129.5 mg/dL+/-70.8 vs. 88.4 mg/dL+/-60.8, p=0.017) than controls. Mean number of CVD risk factors was 1.64+/-1.22 in TA patients and 1.03+/-1.44 among controls, p=0.030. More TA patients presented at least one CVD risk factor when compared to controls (77.2% vs. 51.3%, p=0.048). ET-1 levels were higher in patients than in controls (1.49 pg/mL+/-0.45 vs. 1.27 pg/mL+/-0.32, p=0.034), however no significant difference was found between patients with active and inactive disease. In this study, TA patients presented a higher prevalence of hypertension, higher levels of triglycerides, and ET-1 than controls.
de Souza
Alexandre Wagner Silva
AW
Rheumatology Division, Universidade Federal de São Paulo, Rua Botucatu, 740, 04023-900 São Paulo, SP, Brazil. alexandre_wagner@uol.com.br
Ataíde Mariz
Henrique
H
Torres Reis Neto
Edgard
E
Diniz Arraes
Anne Elizabeth
AE
da Silva
Neusa Pereira
NP
Sato
Emília Inoue
EI
D000328:Adult; D050197:Atherosclerosis / Q000097:blood / Q000150:complications / Q000175:diagnosis; D002318:Cardiovascular Diseases / Q000097:blood* / Q000150:complications* / Q000175:diagnosis; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013625:Takayasu Arteritis / Q000097:blood* / Q000150:complications* / Q000175:diagnosis; D016896:Treatment Outcome; D014280:Triglycerides / Q000378:metabolism
D019332:Endothelin-1; D014280:Triglycerides