title: [Extraction of praeruptorin A from Radix Peucedani by supercritical fluid extraction-CO2].
abstract: OBJECTIVE
  To extract praeruptorin A from Radix Peucedani by supercritical fluid extraction (SFE)-CO2.
  
  
  METHODS
  After preliminary experiment, three main factors were acquired that could influence the result of SFE-CO2, including the time, pressure and temperature of the extraction. The optimal extraction process was carried out on orthogonal design, and SFE-CO2 was compared with the traditional methods.
  
  
  RESULTS
  In the extraction of the praeruptorin A, the best extraction conditions were 60 degrees C, 20 MPa, and duration for three hours. As cosolvent alcohol was added, the amount of extraction of the praeruptorin A increased, and the amount of SFE-CO2 extraction was higher than those of decoction and heating reflux.
  
  
  CONCLUSIONS
  The SFE-CO2 in extracting praeruptorin A from Radix Peucedani is feasible and reliable.
authors.affiliation: Department of Cardiology, Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, Jilin Province 130021, China.
authors.forename: Ai-dong
authors.initials: AD
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Hou
authors.forename: Xue-song
authors.initials: XS
authors.lastname: Chen
authors.forename: Zhi-dong
authors.initials: ZD
authors.lastname: Qiu
mesh_terms: D019661:Apiaceae / Q000737:chemistry*; D025924:Chromatography, Supercritical Fluid / Q000379:methods*; D003374:Coumarins / Q000302:isolation & purification*; D018517:Plant Roots / Q000737:chemistry*
chemical_list: D003374:Coumarins; C441070:praeruptorin A