The postnatal development of intrinsic properties and spike encoding at cortical GABAergic neurons.
GABAergic neurons play a critical role in maintaining the homeostasis of brain functions for well-organized behaviors. It is not known about the dynamical change in signal encoding at these neurons during postnatal development. We investigated this issue at GFP-labeled GABAergic neurons by whole-cell recording in cortical slices of mice. Our results show that the ability of spike encoding at GABAergic neurons is improved during postnatal development. This change is associated with the reduction of refractory periods and threshold potentials of sequential spikes, as well as the improvement of linear correlations between intrinsic properties and spike capacity. Therefore, the postnatal maturation of the spike encoding capacity at GABAergic neurons will stabilize the excitatory state of cerebral cortex.
Wang
Qiyi
Q
Department of Physiology, Bengbu Medical College, Bengbu Anhui, China.
Liu
Xiuping
X
Ge
Rongjing
R
Guan
Sudong
S
Zhu
Yan
Y
Wang
Jin-Hui
JH
D000200:Action Potentials; D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology / Q000254:growth & development* / Q000502:physiology*; D049452:Green Fluorescent Proteins / Q000235:genetics; D051379:Mice; D008815:Mice, Inbred Strains; D009474:Neurons / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D049452:Green Fluorescent Proteins; D005680:gamma-Aminobutyric Acid