Comparison of the effects of dose-dependent zinc chloride on short-term and long-term memory in young male rats.
The aim of the present study was to evaluate the effects of dose-dependent of zinc chloride on short-term and long-term memory in a shuttle box. Young Wistar rats (94+/-10 g) (age 27-30 days) consumed zinc chloride drinking water in five different doses (20, 30, 50, 70 and 100 mg kg(-1) day(-1)) for two weeks by gavage. After 14 days on experimental diets, a shuttle box used to test short- and long-term memory. Two criteria considering for behavioral test, including latency in entering dark chamber and time spent in the dark chamber. This experiment shows that after 2 weeks oral administration of ZnCl2 with (20, 30 and 50 mg kg(-1) day(-1)) doses, the rat's working (short-term) has been improved (p<0.05). Whereas ZnCl2 with 30 mg kg(-1) day(-1) dose has been more effected than other doses (p<0.001). But rat which received ZnCl2 with 100 mg kg(-1) day(-1), has been shown significant impairment in working memory (p<0.05) and there was no significant difference in reference (long-term) memory for any of groups. In general, this study has demonstrated that zinc chloride consumption with 30 mg kg(-1) day(-1) dose for two weeks was more effective than other doses on short-term memory. But consumption of ZnCl2 with 100 mg kg(-1) day(-1) dose for two week had the negative effect on short-term memory. On the other hand, zinc supplementation did not have an effect on long-term memory.
Moazedi
A A
AA
Department of Biology, School of Science, Shahid Chamran University, Ahwaz, Iran.
Ghotbeddin
Z
Z
Parham
G H
GH
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D002712:Chlorides / Q000494:pharmacology*; D003624:Darkness; D004305:Dose-Response Relationship, Drug; D008027:Light; D008297:Male; D008568:Memory / Q000187:drug effects*; D008570:Memory, Short-Term / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D017967:Zinc Compounds / Q000494:pharmacology*
D002712:Chlorides; D017967:Zinc Compounds; C016837:zinc chloride