title: Long-chain polyunsaturated fatty acids in a diabetic teenager during and after nine repeated episodes of diabetic ketoacidosis.
abstract: Type 1 diabetes is often accompanied with acute hypoinsulinemia that may theoretically inhibit the conversion of essential fatty acids to their longer-chain metabolites. Previously, we found significant reduction in plasma arachidonic (C20:4n-6) and docosahexaenoic (C22:6n-3) acid values in a group of diabetic children during diabetic ketoacidosis. Here we report data on the changes of fatty acids in plasma phospholipids in a diabetic teenager during and after nine subsequent episodes of diabetic ketoacidosis (DKA). Plasma phospholipid linoleic acid (C18:2n-6) values significantly decreased [23.05 (1.05) versus 19.22 (3.22), % w/w, median (IQR), p < 0.01], while values of dihomo-gamma-linolenic acid (C20:3n-6) and docosatetraenoic acid (C22:4n-6) significantly increased [1.72 (0.44) versus 1.80 (0.63) and 0.40 (0.01) versus 0.45 (0.07), respectively, p < 0.05]. Values of alpha-linolenic acid (C18:3n-3) did not change, while values of docosahexaenoic acid were significantly higher after than during the ketoacidosis [1.57 (0.67) versus 1.87 (0.32), p < 0.05). These data obtained in the same patient during repeated episodes of diabetic ketoacidosis support the concept that hypoinsulinemia plays an important role in disturbances of essential fatty acid metabolism in diabetes.
authors.affiliation: Department of Pediatrics, University of Pécs, Pécs, Hungary.
authors.forename: Eva
authors.initials: E
authors.lastname: Szabó
authors.forename: Tamás
authors.initials: T
authors.lastname: Marosvölgyi
authors.forename: Adrienne
authors.initials: A
authors.lastname: Kozári
authors.forename: Eva
authors.initials: E
authors.lastname: Erhardt
authors.forename: Gyula
authors.initials: G
authors.lastname: Soltész
authors.forename: Tamás
authors.initials: T
authors.lastname: Decsi
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000503:physiopathology; D016883:Diabetic Ketoacidosis / Q000097:blood* / Q000188:drug therapy* / Q000503:physiopathology; D005231:Fatty Acids, Unsaturated / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007332:Insulin Infusion Systems; D012008:Recurrence
chemical_list: D001786:Blood Glucose; D005231:Fatty Acids, Unsaturated; D006442:Glycated Hemoglobin