A novel and convenient protocol for synthesis of pyridazines.
A new flexible strategy for the synthesis of diversely functionalized pyridazines from 4-chloro-1,2-diaza-1,3-butadienes and active methylene compounds is reported. The high chemoselectivity of this approach offers access to structural precursors of GABA-A antagonist analogues.
Attanasi
Orazio A
OA
Istituto di Chimica Organica, Universita degli Studi di Urbino Carlo Bo, Via I Maggetti 24, 61029 Urbino, Italy.
Favi
Gianfranco
G
Filippone
Paolino
P
Perrulli
Francesca R
FR
Santeusanio
Stefania
S
D002070:Butadienes / Q000737:chemistry; D018756:GABA Antagonists / Q000138:chemical synthesis* / Q000737:chemistry; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry; D013379:Substrate Specificity
D002070:Butadienes; D018756:GABA Antagonists; D011724:Pyridazines; C513630:aminopyridazine; C062482:pyridazine