title: The effect of Equisetum arvense L. (Equisetaceae) in histological changes of pancreatic beta-cells in streptozotocin-induced diabetic in rats.
abstract: In view of alleged, the methanolic extract of Equisetum arvense was analysed for its antidiabetic activity in streptozotocin-induced diabetic rats. The blood glucose lowering activity of the methanolic extract was determined in streptozotocin-induced (50 mg kg(-1), i.p.; dissolved in normal saline) diabetic rats, after oral administration in doses of 50 and 250 mg kg(-1) daily for 5 weeks. The data was compare statistically using one-way ANOVA tukey test. The results showed methanolic extract of Equisetum arvense produced a significant antidiabetic activity at doses 50 and 50 mg kg(-1)/b.wt. Concurrent histological studies of the pancreas of these animals showed comparable regeneration by methanolic extract which were earlier, necrosed by streptozotocin.
authors.affiliation: Department of Biology, Faculty of Science, Urmia University, Iran
authors.forename: Safiyeh
authors.initials: S
authors.lastname: Soleimani
authors.forename: Fathallah Fathi
authors.initials: FF
authors.lastname: Azarbaizani
authors.forename: Vahid
authors.initials: V
authors.lastname: Nejati
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000473:pathology*; D020829:Equisetum / Q000737:chemistry*; D007515:Islets of Langerhans / Q000187:drug effects* / Q000473:pathology; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin
chemical_list: D010936:Plant Extracts; D013311:Streptozocin