HPL-2/HP1 prevents inappropriate vulval induction in Caenorhabditis elegans by acting in both HYP7 and vulval precursor cells.
A current model for Caenorhabditis elegans vulval cell fate specification is that SynMuv genes act redundantly in the hyp7 hypodermal syncytium to repress the LIN-3/EGF inducer and prevent ectopic vulval induction of vulva precursor cells (VPCs). Here we show that the SynMuv gene hpl-2/HP1 has an additional function in VPCs, where it may act through target genes including LIN-39/Hox.
Schott
Sonia
S
Ecole Normale Superieure de Lyon, Laboratory of Molecular and Cellular Biology, UMR5239, 69007 Lyon, France.
Ramos
Fabien
F
Coustham
Vincent
V
Palladino
Francesca
F
D000818:Animals; D017173:Caenorhabditis elegans / Q000196:embryology* / Q000235:genetics / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology*; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics / Q000502:physiology*; D004627:Embryonic Induction / Q000235:genetics / Q000502:physiology; D053595:Embryonic Stem Cells / Q000166:cytology; D004815:Epidermal Growth Factor / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology; D005260:Female; D017238:Genes, Helminth; D015726:Giant Cells / Q000166:cytology; D009154:Mutation; D034622:RNA Interference; D014844:Vulva / Q000166:cytology / Q000196:embryology*
D029742:Caenorhabditis elegans Proteins; D002868:Chromosomal Proteins, Non-Histone; C514742:HPL-2 protein, C elegans; C075912:Lin-3 protein, C elegans; D004815:Epidermal Growth Factor