title: A dissolution-diffusion model for the TAXUS drug-eluting stent with surface burst estimated from continuum percolation.
abstract: A two-layer dissolution-diffusion model is derived which incorporates a surface burst component that is estimated from continuum percolation models of overlapping Poisson distributed spheres. The model is shown to adequately describe the release properties of paclitaxel from a hydrophobic polymer matrix, including the surface burst and sustained release dependence on drug loading.
authors.affiliation: Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, USA.
authors.forename: Victor
authors.initials: V
authors.lastname: Barocas
authors.forename: William
authors.initials: W
authors.lastname: Drasler
authors.forename: Tim
authors.initials: T
authors.lastname: Girton
authors.forename: Ismail
authors.initials: I
authors.lastname: Guler
authors.forename: David
authors.initials: D
authors.lastname: Knapp
authors.forename: Jeff
authors.initials: J
authors.lastname: Moeller
authors.forename: Edward
authors.initials: E
authors.lastname: Parsonage
mesh_terms: D004058:Diffusion; D016503:Drug Delivery Systems; D018625:Microscopy, Atomic Force; D008962:Models, Theoretical; D017239:Paclitaxel / Q000008:administration & dosage; D012995:Solubility; D015607:Stents; D013499:Surface Properties
chemical_list: D017239:Paclitaxel