Early cure rates with narrow-margin slow-Mohs surgery for periocular malignant melanoma.
BACKGROUND
Staged excision with rush-processed paraffin-embedded tissue sections (Slow-Mohs) is an effective treatment for periocular melanoma. Although there is no consensus on initial margins of excision, narrower margins in the eyelids have the functionally and cosmetically important consequence of smaller postoperative wounds.


OBJECTIVE
To report early cure rates for periocular melanoma using Slow-Mohs surgery with en-face margin sectioning.


METHODS
Retrospective, multicenter, noncomparative case series. Slow-Mohs surgery in 14 patients with periocular melanoma from 2000 to 2006.


RESULTS
Fourteen patients underwent 14 Slow-Mohs procedures for eight lentigo maligna, one nodular, and one superficial spreading melanoma, and four lentigo maligna, 12 primary, and two recurrent tumors. The most common site was the lower eyelid (8/14, 57.1%). Breslow thickness ranged from 0.27 to 1.70 mm, with four cases less than 0.76 mm and one case greater than 1.5 mm. Five cases were a Clark level II or greater. Complete excision was achieved with one level (6 cases) or two or three levels (8 cases), with 2- to 3-mm margins at each level in all but one case. With median follow-up of 36 months, there were two local recurrences (2/14, 14.3%).


CONCLUSIONS
Slow-Mohs with en-face sections achieves similar early cure rates to previously published margin-controlled excision techniques. Narrow margins of excision can optimize tissue preservation without compromising outcome.
Then
Siew-Yin
SY
Corneoplastic Unit, Queen Victoria Hospital, East Grinstead, United Kingdom.
Malhotra
Raman
R
Barlow
Richard
R
Kurwa
Habib
H
Huilgol
Shyamala
S
Joshi
Naresh
N
Olver
Jane
J
Collin
Richard
R
Selva
Dinesh
D
D000368:Aged; D000369:Aged, 80 and over; D005123:Eye; D005142:Eyelid Neoplasms / Q000473:pathology / Q000601:surgery; D005153:Facial Neoplasms / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D018327:Hutchinson's Melanotic Freckle / Q000473:pathology / Q000601:surgery; D008297:Male; D008545:Melanoma / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D015580:Mohs Surgery / Q000379:methods*; D012189:Retrospective Studies; D016896:Treatment Outcome