Oral lyophilisate and food immunotherapy: from research to clinical practice.
Thanks to its excellent safety profile, sublingual immunotherapy has served as a basis for launching two important lines of research in current allergology: sublingual immunotherapy with pharmaceutical registry (oral lyophilizates or tablets), and sublingual immunotherapy with food. At present, clinical trials are being conducted which use rapid dissolution oral lyophilizates. The results of the clinical trials carried out in large patient groups and based on a double-blind methodological design have allowed pharmaceutical registry of this form of treatment, with the therapeutic indications of rhinitis and allergy to grasses. Phleum lyophilizate indicated for the treatment of rhinoconjunctivitis will be marketed in Spain in the coming months. In parallel to development of the sublingual route, advances in our knowledge of pollen allergy and its relationship to plant food allergies have facilitated the conducting of studies involving sublingual immunotherapy for allergy to kiwifruit, hazelnut and peach - thus giving rise to promising future perspectives for affected patients.
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Allergology Department. Virgen del Camino Hospital. Pamplona. Spain. atabarpu@navarra.es
D000286:Administration, Sublingual; D000485:Allergens / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D004035:Diet Therapy / Q000379:methods*; D005512:Food Hypersensitivity / Q000178:diet therapy / Q000188:drug therapy*; D005612:Freeze Drying; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D006255:Rhinitis, Allergic, Seasonal / Q000178:diet therapy / Q000188:drug therapy*
D000485:Allergens