title: On the alterations in serum concentration of somatotropin and insuline-like growth factor 1 in lactating cows after the treatment with a little studied recombinant bovine somatotropin.
abstract: A study was performed to delineate bST and IGF-1 variation, over a whole lactation, in cows treated with a nowadays widely commercialised but little studied sustained release formulation of recombinant bST. Total bST levels were found to be exceptionally high in the first days after administration, but decreased rapidly in the second week after injection. The increase in the IGF-1 serum concentration was significant for almost the entire biweekly cycle. Based on this study, the peaks of ST (often above 100 ng/ml) are considered particularly unlikely to be found in non-treated bovines, even under pathological conditions, especially when detected in a number of animals within a herd. Notwithstanding the great heterogeneity of results on this topic, these data suggest that tests against fraud involving the use of rbST in dairy products may be regarded as a feasible possibility.
authors.affiliation: Department of Animal Pathology, Prophylaxis and Food Hygiene, University of Pisa, Pisa, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Castigliego
authors.forename: G
authors.initials: G
authors.lastname: Grifoni
authors.forename: R
authors.initials: R
authors.lastname: Rosati
authors.forename: G
authors.initials: G
authors.lastname: Iannone
authors.forename: A
authors.initials: A
authors.lastname: Armani
authors.forename: D
authors.initials: D
authors.lastname: Gianfaldoni
authors.forename: A
authors.initials: A
authors.lastname: Guidi
mesh_terms: D000818:Animals; D002417:Cattle / Q000097:blood* / Q000378:metabolism*; D003692:Delayed-Action Preparations; D005260:Female; D013006:Growth Hormone / Q000008:administration & dosage / Q000097:blood* / Q000494:pharmacology*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007774:Lactation / Q000502:physiology; D011994:Recombinant Proteins / Q000494:pharmacology*
chemical_list: D003692:Delayed-Action Preparations; D011994:Recombinant Proteins; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone