The aneuploidy paradox in cell growth and tumorigenesis.
Aneuploidy, an abnormal chromosome number, is a frequent characteristic of malignant cells, leading to the suggestion that aneuploidy drives tumorigenesis. In a recent issue of Science, Williams et al. identified a paradoxical relationship between aneuploidy and its linkage to tumorigenesis: chromosome gains in nontransformed cells are antiproliferative, despite frequently occurring in human tumors.
Weaver
Beth A
BA
Department of Pharmacology, University of Wisconsin-Madison, Madison, WI 53706, USA. baweaver@wisc.edu
Cleveland
Don W
DW
D000782:Aneuploidy; D049109:Cell Proliferation; D002875:Chromosomes / Q000648:ultrastructure; D006801:Humans; D007621:Karyotyping; D008957:Models, Genetic; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics*