title: Schistosomiasis haematobia: histopathological course determined by cystoscopy in a patient in whom praziquantel treatment failed.
abstract: Schistosomiasis haematobia or urinary schistosomiasis is one of the main public health problems in Africa and the Middle East. A single dose of 40 mg praziquantel per kg body weight continues to be the treatment of choice for this infection. The aims of this follow-up were to study the post-treatment course of a patient infected with S. haematobium and not submitted to re-exposure, and to identify complications of the disease and/or therapeutic failure after praziquantel treatment by histopathological analysis. Treatments were repeated under medical supervision to ensure the correct use of the drug. In view of the suspicion of lesions in cystoscopy, the patient was submitted to bladder biopsy. The histopathological characteristics observed in biopsies obtained, after each treatment, indicated viability of parasite eggs and activity of granulomas.
authors.affiliation: Seção de Vigilância Epidemiológica, Subdivisão de Pesquisa, Divisão de Ensino e Pesquisa, Instituto de Biologia do Exército, Rio de Janeiro, RJ, Brasil.
authors.forename: Iran Mendonça da
authors.initials: IM
authors.lastname: Silva
authors.forename: Edson
authors.initials: E
authors.lastname: Pereira Filho
authors.forename: Roberto
authors.initials: R
authors.lastname: Thiengo
authors.forename: Paulo César
authors.initials: PC
authors.lastname: Ribeiro
authors.forename: Maria José
authors.initials: MJ
authors.lastname: Conceição
authors.forename: Mônica
authors.initials: M
authors.lastname: Panasco
authors.forename: Henrique Leonel
authors.initials: HL
authors.lastname: Lenzi
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D001706:Biopsy; D003558:Cystoscopy; D006099:Granuloma / Q000469:parasitology / Q000473:pathology; D006801:Humans; D008297:Male; D010270:Parasite Egg Count; D011223:Praziquantel / Q000627:therapeutic use*; D012548:Schistosoma haematobium / Q000302:isolation & purification*; D012553:Schistosomiasis haematobia / Q000188:drug therapy / Q000473:pathology* / Q000652:urine; D017211:Treatment Failure; D001743:Urinary Bladder / Q000469:parasitology* / Q000473:pathology
chemical_list: D000871:Anthelmintics; D011223:Praziquantel