title: Clinical effectiveness of a strontium chloride- containing desensitizing agent over 6 months: a randomized, double-blind, placebo-controlled study.
abstract: OBJECTIVE
  The aim of this multicenter study was to evaluate the clinical efficacy of a strontium chloride-containing desensitizer, Hyposen (Lege Artis), over 6 months.
  
  
  METHODS
  A total of 142 patients with hypersensitivity in 9 dental practices and 2 clinical departments were included in the double-blind, randomized, placebo-controlled study. Each patient exhibited at least 2 hypersensitive and caries-free teeth with exposed dentin surfaces. One tooth was treated with strontium chloride (SR) as recommended by the manufacturer, another with a placebo. Levels of hypersensitivity were assessed after 2, 8, 12, and 24 weeks by cold air and tactile stimuli. After 6 months 132 patients could be reexamined.
  
  
  RESULTS
  A reduction of discomfort and pain was observed in 95 patients (72%) after treatment with SR. Statistical analysis showed a significant positive effect of SR compared to the placebo group (P < .05, McNemar test).
  
  
  CONCLUSIONS
  Use of SR for desensitizing hypersensitive dentin is an effective alternative to existing desensitizing agents.
authors.affiliation: Department of Operative Dentistry and Periodontology, Martin-Luther-University Halle-Wittenberg, Germany. annett.kobler@medizin.uni-halle.de
authors.forename: Annett
authors.initials: A
authors.lastname: Kobler
authors.forename: Oliver
authors.initials: O
authors.lastname: Kub
authors.forename: Hans-Gunter
authors.initials: HG
authors.lastname: Schaller
authors.forename: Christian R
authors.initials: CR
authors.lastname: Gernhardt
mesh_terms: D000293:Adolescent; D000328:Adult; D019905:Benzyl Alcohol / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013324:Strontium / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: C527768:Hyposen; C025700:strontium chloride; D019905:Benzyl Alcohol; D013324:Strontium