A sequel to the tale of p25/Cdk5 in neurodegeneration.
p25/Cdk5 dysregulation may contribute to neurodegeneration. In this issue of Neuron, Kim et al. show that cdk5 inactivates HDAC-1, leading to cell cycle deregulation and DNA damage accumulation. This study provides further insights into the function of p25/Cdk5 in neurons and points to HDAC-1 as a target for therapeutic interventions.
Ikiz
Burcin
B
Department of Neurology, Pathology, and Cell Biology and Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032, USA.
Przedborski
Serge
S
D000818:Animals; D051360:Cyclin-Dependent Kinase 5 / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D009410:Nerve Degeneration / Q000201:enzymology*
D051360:Cyclin-Dependent Kinase 5