Germline polymorphism of cancer susceptibility genes in gynecologic cancer.
The multifactorial process of carcinogenesis involves mutations in oncogenes, or tumor suppressor genes, as well as the influence of environmental etiological factors. Common DNA polymorphisms in low penetrance genes have emerged as genetic factors that seem to modulate an individual's susceptibility to malignancy. Genetic studies, which lead to a true association, are expected to increase understanding of the pathogenesis of each malignancy and to be a powerful tool for prevention and prognosis in the future. Here, we review the findings of genetic association studies of gene polymorphisms in gynecologic cancer with special reference to glutathione-S-transferase, FAS/CD95 and p53 genes including our recent research results.
Ueda
Masatsugu
M
Cytopathology and Gynecology, Osaka Cancer Prevention and Detection Center, Osaka, Japan. mueda@gan-osaka.or.jp
Toji
Eisaku
E
Nunobiki
Osamu
O
Izuma
Shinji
S
Okamoto
Yoshiaki
Y
Torii
Kiyo
K
Noda
Sadamu
S
D000483:Alleles; D003062:Codon / Q000235:genetics; D004247:DNA / Q000235:genetics*; D005260:Female; D016158:Genes, p53 / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005833:Genital Neoplasms, Female / Q000235:genetics*; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics; D019014:fas Receptor / Q000235:genetics*
D003062:Codon; D019014:fas Receptor; D004247:DNA; D005982:Glutathione Transferase