title: [The change of cyclooxygenase-2 and inducible nitric oxide synthase in the gastric mucosa one year after eradication of Helicobacter pylori].
abstract: OBJECTIVE
  The cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), the proteins that have the role in the gastric carcinogenesis, are stimulated by H. pylori infection in the gastric mucosa. The aim of this study was to evaluate the expression of COX-2 and iNOS proteins one year after the eradication of H. pylori.
  
  
  METHODS
  Gastric antral mucosa from fifty eight patients with chronic gastritis who were all infected with H. pylori was examined for the expression of COX-2 and iNOS proteins before and one year after the eradication of H. pylori by immunohistochemical stain.
  
  
  RESULTS
  COX-2 and iNOS proteins were expressed in the epithelial cells and interstitial inflammatory cells of gastric mucosa. Percent expressions of COX-2 and iNOS were significantly decreased one year after the eradication in the patients with cured infection, but not in those having persistent H. pylori. COX-2 and iNOS expressions were well correlated with H. pylori density, acute and chronic inflammation of gastric mucosa.
  
  
  CONCLUSIONS
  The eradication of H. pylori can decrease the expression of COX-2 and iNOS in the gastric mucosa in long-term period. This seems to be due to the removal of H. pylori itself and related regression of gastric inflammation.
authors.affiliation: Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
authors.forename: Sung Soo
authors.initials: SS
authors.lastname: Kim
authors.forename: Young Jick
authors.initials: YJ
authors.lastname: Sung
authors.forename: Min Kyoung
authors.initials: MK
authors.lastname: Park
authors.forename: Chang Hoon
authors.initials: CH
authors.lastname: Lim
authors.forename: Hong Jun
authors.initials: HJ
authors.lastname: Yang
authors.forename: Tae Ho
authors.initials: TH
authors.lastname: Kim
authors.forename: Chang Whan
authors.initials: CW
authors.lastname: Kim
authors.forename: Jin Il
authors.initials: JI
authors.lastname: Kim
authors.forename: Sok Won
authors.initials: SW
authors.lastname: Han
authors.forename: In Sik
authors.initials: IS
authors.lastname: Chung
mesh_terms: D051546:Cyclooxygenase 2 / Q000276:immunology / Q000378:metabolism*; D004359:Drug Therapy, Combination; D005753:Gastric Mucosa / Q000201:enzymology*; D016481:Helicobacter Infections / Q000188:drug therapy; D016480:Helicobacter pylori; D006801:Humans; D052247:Nitric Oxide Synthase Type II / Q000276:immunology / Q000378:metabolism*; D013997:Time Factors
chemical_list: C496319:NOS2 protein, human; D052247:Nitric Oxide Synthase Type II; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human