[Serum levels of soluble CD(23) and thrombopoietin in chronic lymphocytic leukemia].
OBJECTIVE
To investigate the serum levels of soluble CD(23) (sCD(23)) and thrombopoietin (TPO) in chronic lymphocytic leukemia (CLL) and their correlation with other prognostic factors.


METHODS
The serum levels of sCD(23) and TPO of 25 CLL patients were detected with enzyme linked immunosorbent assay. Flow cytometry was employed to determine the expression of CD(38) and ZAP-70 protein.


RESULTS
TPO level in CLL patients was significantly higher than that in normal controls 67.22 - 1881.77 ng/L and 70.29 - 147.98 ng/L respectively, P = 0.003. sCD(23) level in CLL patients was significantly higher than that in normal controls 129.80 - 405.31 U/ml and 0.65 - 32.99 U/ml respectively, P = 0.000. TPO level was significantly correlated with Binet stage and CD(38) expression. Patients in stage B and C had higher level of TPO than those in stage A 140.57 - 457.48 ng/L and 121.92 - 163.83 ng/L respectively, P = 0.014, while TPO level was higher in patients with higher CD(38) expression than in patients lower CD(38) expression 113.23 - 199.10 ng/L and 141.34 - 454.92 ng/L respectively, P = 0.033. No significant correlation of sCD(23) and TPO levels with ZAP-70 protein, sex, age, peripheral lymphocyte count and lactate dehydrogenase were observed.


CONCLUSIONS
Serum TPO level might be a prognostic factor in CLL.
Yu
Hui
H
Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Provincial Hospital, Nanjing 210029, China.
Xu
Wei
W
Shen
Qiu-Dan
QD
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D017455:Receptors, IgE / Q000097:blood*; D013926:Thrombopoietin / Q000097:blood*
D017455:Receptors, IgE; D013926:Thrombopoietin