title: Palladium-catalyzed Suzuki-Miyaura coupling of pyridyl-2-boronic esters with aryl halides using highly active and air-stable phosphine chloride and oxide ligands.
abstract: The palladium-catalyzed Suzuki-Miyaura coupling of pyridyl-2-boronic esters provided an efficient approach to useful biaryl building blocks containing a 2-pyridyl moiety. The convenient reaction protocol demonstrates its potentially wide applications in medicinal chemistry.
authors.affiliation: Department of Medicinal Chemistry, Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065-0900, USA.
authors.forename: David X
authors.initials: DX
authors.lastname: Yang
authors.forename: Steven L
authors.initials: SL
authors.lastname: Colletti
authors.forename: Kevin
authors.initials: K
authors.lastname: Wu
authors.forename: Maoying
authors.initials: M
authors.lastname: Song
authors.forename: George Y
authors.initials: GY
authors.lastname: Li
authors.forename: Hong C
authors.initials: HC
authors.lastname: Shen
mesh_terms: D000388:Air; D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D004952:Esters / Q000737:chemistry*; D006219:Halogens / Q000737:chemistry*; D008024:Ligands; D010087:Oxides / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*
chemical_list: D001897:Boronic Acids; D004952:Esters; D006219:Halogens; D008024:Ligands; D010087:Oxides; D010720:Phosphines; D010165:Palladium; C044646:phosphine