Repair of DNA lesions associated with triplex-forming oligonucleotides.
Triplex-forming oligonucleotides (TFOs) are gene targeting tools that can bind in the major groove of duplex DNA in a sequence-specific manner. When bound to DNA, TFOs can inhibit gene expression, can position DNA-reactive agents to specific locations in the genome, or can induce targeted mutagenesis and recombination. There is evidence that third strand binding, alone or with an associated cross-link, is recognized and metabolized by DNA repair factors, particularly the nucleotide excision repair pathway. This review examines the evidence for DNA repair of triplex-associated lesions.
Chin
Joanna Y
JY
Departments of Therapeutic Radiology and Genetics, Yale University School of Medicine, 15 York Street, New Haven, CT 06510, USA.
Glazer
Peter M
PM
D000818:Animals; D004247:DNA / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism
D009841:Oligonucleotides; C051802:triplex DNA; D004247:DNA