title: The use of hypertonic saline for fluid resuscitation in sepsis: a review.
abstract: Early volume resuscitation of a patient with sepsis has been shown to reduce morbidity, mortality, and healthcare resource consumption. Hypertonic saline offers a theoretically viable option for volume resuscitation. This article reviews the current information available regarding fluid resuscitation in patients with sepsis, with emphasis on the use of hypertonic saline.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA.
authors.forename: Anil
authors.initials: A
authors.lastname: Singh
authors.forename: Brian W
authors.initials: BW
authors.lastname: Carlin
authors.forename: Daniel
authors.initials: D
authors.lastname: Shade
authors.forename: Peter D
authors.initials: PD
authors.lastname: Kaplan
mesh_terms: D000818:Animals; D003102:Colloids / Q000627:therapeutic use; D003422:Critical Care / Q000379:methods; D000077324:Crystalloid Solutions; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005440:Fluid Therapy / Q000379:methods*; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000627:therapeutic use; D007552:Isotonic Solutions / Q000627:therapeutic use; D018579:Patient Selection; D010952:Plasma Substitutes / Q000627:therapeutic use; D010953:Plasma Volume; D012151:Resuscitation / Q000379:methods*; D000077325:Ringer's Lactate; D012462:Saline Solution, Hypertonic / Q000494:pharmacology / Q000627:therapeutic use*; D018805:Sepsis / Q000628:therapy*; D012965:Sodium Chloride / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D003102:Colloids; D000077324:Crystalloid Solutions; D006895:Hydroxyethyl Starch Derivatives; D007552:Isotonic Solutions; D010952:Plasma Substitutes; D000077325:Ringer's Lactate; D012462:Saline Solution, Hypertonic; D012965:Sodium Chloride