Hypoglycaemia in Type 2 diabetes.
Rates of hypoglycaemia in those with Type 2 diabetes newly started on insulin are less than in Type 1 diabetes but rise with time. As insulin secretion declines, the ability to release glucagon is diminished. Adrenaline release partially compensates for deficient glucagon secretion but is vulnerable to repeated hypoglycaemia leading to diminished sympathoadrenal activation. Thus the inevitable decline in endogenous insulin, eventually produces a similar failure of physiological protection to hypoglycaemia as in Type 1 diabetes.
Heller
Simon R
SR
Academic Unit of Diabetes, Endocrinology and Metabolism, University of Sheffield, Room OU141, School of Medicine and Biomedical Sciences, Beech Hill Road, Sheffield S10 2RX, UK. s.heller@sheffield.ac.uk
D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000503:physiopathology*; D005934:Glucagon / Q000378:metabolism; D006801:Humans; D007003:Hypoglycemia / Q000188:drug therapy / Q000453:epidemiology / Q000378:metabolism* / Q000473:pathology*
D005934:Glucagon