Gastric-and-intestinal mixed endocrine cell phenotypic expression of carcinoid tumors in the rectum.
We have previously demonstrated that gastric and intestinal endocrine cell (End-cell) marker expression is important for assessment of the histogenesis of endocrine cell tumors. However, the End-cell phenotypes of carcinoid tumors in the rectum remain largely unclear. We therefore examined marker expression of rectal carcinoid tumors. We evaluated 20 rectal carcinoid tumors (as well as 8 from the stomach for comparison) phenotypically, using gastrin, gastric inhibitory polypeptide (GIP) and glucagons-like peptide-1 (GLP-1) as End-cell markers. Rectal carcinoid tumors were divided into 3 endocrine-gastric (e-G), 16 endocrine-gastric-and-intestinal mixed (e-GI), 1 endocrine-intestinal (e-I), and 0 endocrine-null (e-N) types, thus 19 (e-G+ e-GI types, 95%) had gastric phenotypic expression, while 17 (e-GI+ e-I types, 85%) harbored intestinal elements. Stomach carcinoid tumors were classified as 6 e-G and 2 e-N types, respectively. In conclusion, most rectal carcinoid tumors exhibited the e-GI type, suggesting the importance of gastric End-cell marker expression for histogenesis of the rectal carcinoid tumors. Further studies of pathological and biological analyses are needed to clarify the histogenesis of the carcinoid tumors.
Hirata
Yoshikazu
Y
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan.
Mizoshita
Tsutomu
T
Mizushima
Takashi
T
Shimura
Takaya
T
Mori
Yoshinori
Y
Kubota
Eiji
E
Wada
Tsuneya
T
Ogasawara
Naotaka
N
Tanida
Satoshi
S
Kataoka
Hiromi
H
Sasaki
Makoto
M
Kamiya
Takeshi
T
Tsukamoto
Tetsuya
T
Tatematsu
Masae
M
Joh
Takashi
T
D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis*; D002276:Carcinoid Tumor / Q000145:classification / Q000378:metabolism*; D055098:Endocrine Cells / Q000378:metabolism; D005260:Female; D005749:Gastric Inhibitory Polypeptide / Q000096:biosynthesis; D005755:Gastrins / Q000096:biosynthesis; D052216:Glucagon-Like Peptide 1 / Q000096:biosynthesis; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012004:Rectal Neoplasms / Q000145:classification / Q000378:metabolism*
D014408:Biomarkers, Tumor; D005755:Gastrins; D005749:Gastric Inhibitory Polypeptide; D052216:Glucagon-Like Peptide 1