Moist Exposed Burn Ointment (MEBO) in partial thickness burns - a randomized, comparative open mono-center study on the efficacy of dermaheal (MEBO) ointment on thermal 2nd degree burns compared to conventional therapy.
OBJECTIVE
Wound healing in burn wounds presents a challenge in healthcare, and there is still a lack of alternatives in topical burn wound treatments. - The purpose of this study was to evaluate the efficacy of a new therapeutic ointment (MEBO) in the treatment of partial thickness burns.


METHODS
40 patients received either topical treatment with Moist Exposed Burn Ointment (MEBO) or standard Flammazine treatment. All patients suffered from partial-thickness burn injuries (< 20% TBSA). Wounds were evaluated for 60 up to days regarding wound healing, water loss, inflammation, and pain alleviation.


RESULTS
For transepidermal water loss, there was a difference of 2.3 gr/m2/h between MEBO, and Flammazine, favoring MEBO. However, this difference was not statistically significant (p=0.78). For all secondary efficacy parameter results were similar. -


CONCLUSIONS
This study showed that MEBO ointment for topical treatment of burn injuries presents an attractive alternative for the topical treatment of limited partial thickness thermal burns.
Hirsch
T
T
Department of Plastic, and Reconstructive Surgery, Helios Klinikum Wuppertal, University of Witten/Herdecke, Germany.
Ashkar
W
W
Schumacher
O
O
Steinstraesser
L
L
Ingianni
G
G
Cedidi
C C
CC
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D001458:Bandages; D002056:Burns / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009824:Ointments / Q000008:administration & dosage*; D017288:Pain Threshold / Q000187:drug effects; D012720:Severity of Illness Index; D012837:Silver Sulfadiazine / Q000008:administration & dosage*; D016896:Treatment Outcome; D014867:Water / Q000378:metabolism; D014945:Wound Healing / Q000187:drug effects; D055815:Young Adult
D000891:Anti-Infective Agents, Local; D009824:Ointments; D014867:Water; D012837:Silver Sulfadiazine