Pathotype and susceptibility profile of a community-acquired methicillin-resistant Staphylococcus aureus strain responsible for a case of severe pneumonia.
Recent articles have described an increasing number of infections due to Panton-Valentine leukocidin PVL-positive community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) worldwide. We report a case of necrotizing pneumonia successfully treated with levofloxacin in Italy, sustained by a PVL-positive CA-MRSA, belonging to ST88 and carrying a staphylococcal chromosomal cassette mec type V. Further molecular characterization of isolates revealed that they were PVL positive, belonged to the agr IV allele, possessed a capsular type 8, and had an almost complete pathotype composed of leukocidins and numerous adhesins. In addition, the strains were strong biofilm producers.
Stefani
Stefania
S
Department of Microbiology, University of Catania, 95124 Catania (I), Italy. stefanis@unict.it
Bongiorno
Dafne
D
Cafiso
Viviana
V
Campanile
Floriana
F
Crapis
Massimo
M
Cristini
Francesco
F
Sartor
Assunta
A
Scarparo
Claudio
C
Spina
Daniela
D
Viale
Pierluigi
P
D000328:Adult; D001426:Bacterial Proteins / Q000235:genetics; D001427:Bacterial Toxins / Q000235:genetics; D017714:Community-Acquired Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D017931:DNA Primers / Q000235:genetics; D005098:Exotoxins / Q000235:genetics; D006801:Humans; D007558:Italy; D007956:Leukocidins / Q000235:genetics; D064704:Levofloxacin; D008297:Male; D016106:Methicillin Resistance / Q000235:genetics*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000627:therapeutic use; D011023:Pneumonia, Staphylococcal / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D016133:Polymerase Chain Reaction; D012703:Serotyping
D001426:Bacterial Proteins; D001427:Bacterial Toxins; D017931:DNA Primers; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin; D064704:Levofloxacin; D015242:Ofloxacin