A new strategy to probe the genotoxicity of silver nanoparticles combined with cetylpyridine bromide.
The environmental genotoxic behavior of silver nanoparticles (nanoAg) combined with the detergent cetylpyridine bromide (CPB) was examined in vitro. The experimental results showed that the genotoxicity of nanoAg itself is weak, but nanoAg shows obvious genotoxicity after combined with CPB. The combined materials have a strong coeffect on calf thymus DNA (ctDNA) at a concentration of 3.3 x 10(-6 )gmL(-1) nanoAg and 6.0 x 10(-6) molL(-1) CPB. After the addition of ctDNA to the nanoAg-CPB system, the particles are scattered and the diameter decreases, which indirectly reveal that nanoAg-CPB has genotoxicity.
Chi
Zhenxing
Z
School of Environmental Science and Engineering, Shandong University, 27 Shanda South Road, Jinan 250100, PR China.
Liu
Rutao
R
Zhao
Lingzi
L
Qin
Pengfei
P
Pan
Xingren
X
Sun
Feng
F
Hao
Xiaopeng
X
D000042:Absorption; D000818:Animals; D001965:Bromides / Q000737:chemistry*; D002417:Cattle; D002594:Cetylpyridinium / Q000737:chemistry / Q000633:toxicity*; D004247:DNA / Q000032:analysis / Q000737:chemistry* / Q000648:ultrastructure; D003902:Detergents / Q000737:chemistry / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D008027:Light; D053768:Metal Nanoparticles / Q000737:chemistry / Q000633:toxicity* / Q000648:ultrastructure; D010316:Particle Size; D012542:Scattering, Radiation; D012834:Silver / Q000737:chemistry / Q000633:toxicity; D013056:Spectrophotometry, Ultraviolet
D001965:Bromides; D003902:Detergents; D012834:Silver; D004247:DNA; C427203:calf thymus DNA; D002594:Cetylpyridinium