title: Photoinduced nitric oxide and singlet oxygen release from ZnPC liposome vehicle associated with the nitrosyl ruthenium complex: synergistic effects in photodynamic therapy application.
abstract: Under continuous photolysis at 675 nm, liposomal zinc phthalocyanine associated with nitrosyl ruthenium complex [Ru(NH.NHq)(tpy)NO](3+) showed the detection and quantification of nitric oxide (NO) and singlet oxygen ((1)O(2)) release. Photophysical and photochemical results demonstrated that the interaction between the nitrosyl ruthenium complex and the photosensitizer can enable an electron transfer process from the photosensitizer to the nitrosyl ruthenium complex which leads to NO release. Synergistic action of both photosensitizers and the nitrosyl ruthenium complex results in the production of reactive oxygen species and reactive nitrogen species, which is a potent oxidizing agent to many biological tissues, in particular neoplastic cells.
authors.affiliation: Departamento de Química, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto SP, Brazil.
authors.forename: Daniela Silva
authors.initials: DS
authors.lastname: Maranho
authors.forename: Renata Galvão
authors.initials: RG
authors.lastname: de Lima
authors.forename: Fernando Lucas
authors.initials: FL
authors.lastname: Primo
authors.forename: Roberto Santana
authors.initials: RS
authors.lastname: da Silva
authors.forename: Antonio Claudio
authors.initials: AC
authors.lastname: Tedesco
mesh_terms: D004563:Electrochemistry; D005453:Fluorescence; D008081:Liposomes; D009569:Nitric Oxide / Q000737:chemistry*; D010777:Photochemistry; D010778:Photochemotherapy; D017975:Ruthenium Compounds / Q000737:chemistry*; D026082:Singlet Oxygen / Q000737:chemistry*
chemical_list: D008081:Liposomes; D017975:Ruthenium Compounds; D026082:Singlet Oxygen; D009569:Nitric Oxide