title: Does loss of CD151 expression promote the metastasis of hypoxic colon cancer cells?
abstract: Intratumoral hypoxia increases invasion and metastasis through multiple mechanisms, including changes in gene expression that are mediated by hypoxia-inducible factor 1. In hypoxic colon cancer cells, hypoxia-inducible factor 1 inhibits the expression of CD151, a cell surface molecule that normally tethers epithelial cells to the basement membrane, which may promote metastasis.
authors.affiliation: Vascular Program, Institute for Cell Engineering, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. gsemenza@jhmi.edu
authors.forename: Gregg L
authors.initials: GL
authors.lastname: Semenza
mesh_terms: D015703:Antigens, CD / Q000032:analysis*; D002448:Cell Adhesion; D015687:Cell Hypoxia; D003110:Colonic Neoplasms / Q000473:pathology*; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D060185:Tetraspanin 24
chemical_list: D015703:Antigens, CD; C554715:CD151 protein, human; D060185:Tetraspanin 24