[Pathophysiology of invasive fungal infection in diabetic patients].
It has been known that diabetes mellitus impairs functioning of neutrophil, macrophage, cellular immunity, humoral immunity, and iron metabolism. In addition to them, diabetes-related angiopathy leads a patient to being at high-risk individual for several kinds of infectious diseases. Therefore, diabetes has been accepted as one of the important risk factors for invasive fungal infection. From the viewpoint of pathology, the present review describes both pathophysiology of immunosuppression induced by diabetes and histopathological characteristics of typical forms in invasive fungal infection when it occurred as an opportunistic infection; those are candidiasis, aspergillosis, and cryptococcosis. We wish to draw that pathophysiological explanation still remains obscuring of relationship between diabetes and invasive fungal infection.
Okubo
Yoichiro
Y
Department of Surgical Pathology, Toho University School of Medicine.
Nakayama
Haruo
H
Hasegawa
Chikako
C
Mitsuda
Aki
A
Hatori
Tsutomu
T
Tanikawa
Kayoko
K
Shinozaki
Minoru
M
Shibuya
Kazutoshi
K
D002177:Candidiasis / Q000150:complications* / Q000473:pathology*; D020314:Central Nervous System Fungal Infections / Q000150:complications / Q000473:pathology; D003453:Cryptococcosis / Q000150:complications* / Q000473:pathology*; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000276:immunology; D006801:Humans; D016867:Immunocompromised Host; D055744:Invasive Pulmonary Aspergillosis / Q000150:complications / Q000473:pathology; D008172:Lung Diseases, Fungal / Q000150:complications* / Q000473:pathology*; D009894:Opportunistic Infections / Q000150:complications; D012307:Risk Factors