New sequence variants associated with bone mineral density.
In an extended genome-wide association study of bone mineral density among 6,865 Icelanders and a follow-up in 8,510 subjects of European descent, we identified four new genome-wide significant loci. These are near the SOST gene at 17q21, the MARK3 gene at 14q32, the SP7 gene at 12q13 and the TNFRSF11A (RANK) gene at 18q21. Furthermore, nonsynonymous SNPs in the C17orf53, LRP4, ADAM19 and IBSP genes were suggestively associated with bone density.
Styrkarsdottir
Unnur
U
deCODE Genetics, Reykjavik, Iceland. unnur.styrkarsdottir@decode.is
Halldorsson
Bjarni V
BV
Gretarsdottir
Solveig
S
Gudbjartsson
Daniel F
DF
Walters
G Bragi
GB
Ingvarsson
Thorvaldur
T
Jonsdottir
Thorbjorg
T
Saemundsdottir
Jona
J
Snorradóttir
Steinunn
S
Center
Jacqueline R
JR
Nguyen
Tuan V
TV
Alexandersen
Peter
P
Gulcher
Jeffrey R
JR
Eisman
John A
JA
Christiansen
Claus
C
Sigurdsson
Gunnar
G
Kong
Augustine
A
Thorsteinsdottir
Unnur
U
Stefansson
Kari
K
D001483:Base Sequence; D015519:Bone Density / Q000235:genetics*; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics; D005260:Female; D050723:Fractures, Bone / Q000150:complications / Q000235:genetics; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D014947:Wounds and Injuries / Q000150:complications / Q000235:genetics