Kinetochore attachment: how the hec can a cell do it?
Creating stable yet flexible attachments of spindle microtubules to the kinetochore is critical for facilitating chromosome congression, segregation, and checkpoint signaling. Two new studies have elucidated the molecular details of how the Ndc80 complex mediates this dynamic attachment.
Cai
Shang
S
Biochemistry Program and Medical Sciences, Indiana University, 915 E. 3rd Street, Myers Hall 262, Bloomington, IN 47405, USA.
Walczak
Claire E
CE
D020090:Chromosome Segregation; D003598:Cytoskeletal Proteins; D005786:Gene Expression Regulation; D006801:Humans; D018386:Kinetochores / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism*; D008938:Mitosis; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D008941:Spindle Apparatus / Q000378:metabolism; D014404:Tubulin / Q000235:genetics / Q000378:metabolism*
D003598:Cytoskeletal Proteins; C120529:NDC80 protein, human; D009687:Nuclear Proteins; D014404:Tubulin