[Pharmaceutical characteristics of brucine stealth liposomes].
OBJECTIVE
To prepare brucine stealth liposomes and compare the in vitro characteristics with brucine conventional liposomes.


METHODS
Brucine stealth liposomes and conventional liposomes were both prepared by ammonium sulfate transmembrane gradients. The encapsulation efficiency, particle size, in vitro release profiles and stability were compared respectively.


RESULTS
The encapsulation efficiency of brucine stealth liposomes and conventional liposomes were (80.7 +/- 0.5)%, and (80.5 +/- 0.3)%, respectively. The mean paricle sizes were 103.5 nm and 169. 4 nm, respectively. Whether rat plasma was added or not, the release rate and degree of brucine stealth liposomes were significantly lower than those of conventional liposomes. Brucine stealth liposomes were more stable than conventional liposomes.


CONCLUSIONS
As the antitumor durg delivery system, the in vitro characteristics of brucine stealth liposomes are more satisfactory than the corresponding conventional liposomes.
Chen
Jun
J
College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210029, China.
Wang
Wei
W
Cai
Bao-chang
BC
Hu
Wei
W
Wang
Li-jie
LJ
D000818:Animals; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000493:pharmacokinetics; D008081:Liposomes / Q000737:chemistry* / Q000493:pharmacokinetics; D010316:Particle Size; D051381:Rats; D013331:Strychnine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics
D004365:Drugs, Chinese Herbal; D008081:Liposomes; C083806:brucine; D013331:Strychnine