title: Remodeling the brain with behavioral experience after stroke.
abstract: OBJECTIVE
  Behavioral experience can drive brain plasticity, but we lack sufficient knowledge to optimize its therapeutic use after stroke.
  
  
  METHODS
  We outline recent findings from rodent models of cortical stroke of how experiences interact with postinjury events to influence synaptic connectivity and functional outcome. We focus on upper extremity function.
  
  
  RESULTS
  After unilateral cortical infarcts, behavioral experiences shape neuronal structure and activity in both hemispheres. Experiences that matter include interventions such as skill training and constraint-like therapy as well as unguided behaviors such as learned nonuse and behavioral compensation. Lateralized behaviors have bihemispheric influences. Ischemic injury can alter the sensitivity of remaining neocortical neurons to behavioral change and this can have positive and negative functional effects.
  
  
  CONCLUSIONS
  Because experience is ongoing in stroke survivors, a better understanding of its interaction with brain reorganization is needed so that it can be manipulated to improve function and prevent its worsening.
authors.affiliation: Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA. tj@psy.utexas.edu
authors.forename: Theresa A
authors.initials: TA
authors.lastname: Jones
authors.forename: Rachel P
authors.initials: RP
authors.lastname: Allred
authors.forename: Deanna L
authors.initials: DL
authors.lastname: Adkins
authors.forename: J Edward
authors.initials: JE
authors.lastname: Hsu
authors.forename: Amber
authors.initials: A
authors.lastname: O'Bryant
authors.forename: Mónica A
authors.initials: MA
authors.lastname: Maldonado
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D004195:Disease Models, Animal; D006801:Humans; D009044:Motor Cortex / Q000503:physiopathology; D009473:Neuronal Plasticity / Q000502:physiology*; D051381:Rats; D020127:Recovery of Function / Q000502:physiology; D020521:Stroke / Q000503:physiopathology; D000071939:Stroke Rehabilitation