Transcriptome and proteome analyses of drug interactions with natural products.
Advances in high-throughput technologies to measure genome-scale changes of genes, proteins, and other biomolecular components ('omics') in complex biological systems have dramatically revolutionized biomedical research. However, the benefits of utilizing omics information in drug development have not yet been fully realized. Fortunately, the integration of modern systems biology efforts with traditional medicine philosophies, together with integrative bioinformatics, has driven the development of a new drug discovery paradigm. Using leukemia as a disease model, therapeutic synergism between drugs and natural products has been investigated by incorporating transcriptomics and proteomics data into a network-like understanding. Here, these recent advancements will be discussed in detail, along with perspectives in the field of drug synergism.
Fang
Hai
H
Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine (SJTUSM), and Ruijin Hospital, Shanghai, China.
Wang
Kankan
K
Zhang
Ji
J
D000818:Animals; D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000008:administration & dosage; D001549:Benzamides; D055808:Drug Discovery; D004357:Drug Synergism; D020869:Gene Expression Profiling; D041743:Herb-Drug Interactions; D006801:Humans; D000068877:Imatinib Mesylate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy* / Q000378:metabolism; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy* / Q000378:metabolism; D010087:Oxides / Q000008:administration & dosage; D010879:Piperazines / Q000008:administration & dosage; D020543:Proteome; D011743:Pyrimidines / Q000008:administration & dosage; D014212:Tretinoin / Q000008:administration & dosage
D001152:Arsenicals; D001549:Benzamides; D010087:Oxides; D010879:Piperazines; D020543:Proteome; D011743:Pyrimidines; D014212:Tretinoin; D000068877:Imatinib Mesylate; D000077237:Arsenic Trioxide