title: Gastric-and-intestinal mixed endocrine cell phenotypic expression of carcinoid tumors in the rectum.
abstract: We have previously demonstrated that gastric and intestinal endocrine cell (End-cell) marker expression is important for assessment of the histogenesis of endocrine cell tumors. However, the End-cell phenotypes of carcinoid tumors in the rectum remain largely unclear. We therefore examined marker expression of rectal carcinoid tumors. We evaluated 20 rectal carcinoid tumors (as well as 8 from the stomach for comparison) phenotypically, using gastrin, gastric inhibitory polypeptide (GIP) and glucagons-like peptide-1 (GLP-1) as End-cell markers. Rectal carcinoid tumors were divided into 3 endocrine-gastric (e-G), 16 endocrine-gastric-and-intestinal mixed (e-GI), 1 endocrine-intestinal (e-I), and 0 endocrine-null (e-N) types, thus 19 (e-G+ e-GI types, 95%) had gastric phenotypic expression, while 17 (e-GI+ e-I types, 85%) harbored intestinal elements. Stomach carcinoid tumors were classified as 6 e-G and 2 e-N types, respectively. In conclusion, most rectal carcinoid tumors exhibited the e-GI type, suggesting the importance of gastric End-cell marker expression for histogenesis of the rectal carcinoid tumors. Further studies of pathological and biological analyses are needed to clarify the histogenesis of the carcinoid tumors.
authors.affiliation: Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Hirata
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Mizoshita
authors.forename: Takashi
authors.initials: T
authors.lastname: Mizushima
authors.forename: Takaya
authors.initials: T
authors.lastname: Shimura
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Mori
authors.forename: Eiji
authors.initials: E
authors.lastname: Kubota
authors.forename: Tsuneya
authors.initials: T
authors.lastname: Wada
authors.forename: Naotaka
authors.initials: N
authors.lastname: Ogasawara
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tanida
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kataoka
authors.forename: Makoto
authors.initials: M
authors.lastname: Sasaki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kamiya
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tsukamoto
authors.forename: Masae
authors.initials: M
authors.lastname: Tatematsu
authors.forename: Takashi
authors.initials: T
authors.lastname: Joh
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis*; D002276:Carcinoid Tumor / Q000145:classification / Q000378:metabolism*; D055098:Endocrine Cells / Q000378:metabolism; D005260:Female; D005749:Gastric Inhibitory Polypeptide / Q000096:biosynthesis; D005755:Gastrins / Q000096:biosynthesis; D052216:Glucagon-Like Peptide 1 / Q000096:biosynthesis; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012004:Rectal Neoplasms / Q000145:classification / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D005755:Gastrins; D005749:Gastric Inhibitory Polypeptide; D052216:Glucagon-Like Peptide 1