Sauroine, an alkaloid from Huperzia saururus with activity in wistar rats in electrophysiological and behavioral assays related to memory retention.
The present study describes the effects of sauroine (1), the main alkaloid obtained from Huperzia saururus, on memory retention and learning. To evaluate this, electrophysiological experiments and behavioral tests (step down) were performed on male Wistar rats. The results showed that 1 improved memory retention in the step-down test, significantly increasing hippocampal plasticity. Thus, 1 seems to be a constituent responsible for the activity claimed in folk medicine for H. saururus in Argentina.
Vallejo
Mariana G
MG
Farmacognosia, Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Instituto Multidisciplinario de Biología Vegetal (IMBIV-CONICET), Edificio de Ciencias 2, Ciudad Universitaria, 5000 Córdoba, Argentina.
Ortega
María G
MG
Cabrera
José L
JL
Carlini
Valeria P
VP
de Barioglio
Susana Rubiales
SR
Almirón
Romina S
RS
Ramírez
Oscar A
OA
Agnese
A Mariel
AM
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D001118:Argentina; D001519:Behavior / Q000187:drug effects*; D006624:Hippocampus / Q000187:drug effects; D032501:Huperzia / Q000737:chemistry*; D008297:Male; D008568:Memory / Q000187:drug effects*; D009043:Motor Activity / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
D000470:Alkaloids; C535132:sauroine