title: Antimicrobial and cytotoxic activity of Marrubium alysson and Retama raetam grown in Tunisia.
abstract: Antibacterial and antifungal activities of extracts obtained from M. alysson, R. raetam were tested using a solid medium technique. We showed that the petroleum ether extract of M. alysson had a Minimum Inhibitory Concentration (MIC) varied from 128 to 2000 microg mL(-1) against different Enterobacteriaceae and antifungal activity against Candida glabrata, Candida albicans, Candida parapsilosis and Candida kreusei with a MIC of 256 microg mL(-1). The ethyl acetate extract of R. raetam showed the best activity against Gram positive organisms with MICs of 128 to 256 microg mL(-1) against methicillin resistant Staphylococcus aureus but low activity against the different Candida species.
authors.affiliation: Laboratoire Des Maladies Transmissibles et Des Substances Biologiquement Actives-Faculté de Pharmacie-5000-Monastir, Tunisie.
authors.forename: Edziri
authors.initials: E
authors.lastname: Hayet
authors.forename: Ammar
authors.initials: A
authors.lastname: Samia
authors.forename: Groh
authors.initials: G
authors.lastname: Patrick
authors.forename: Mahjoub Mohamed
authors.initials: MM
authors.lastname: Ali
authors.forename: Mastouri
authors.initials: M
authors.lastname: Maha
authors.forename: Gutmann
authors.initials: G
authors.lastname: Laurent
authors.forename: Zine
authors.initials: Z
authors.lastname: Mighri
authors.forename: Laouni
authors.initials: L
authors.lastname: Mahjoub
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects*; D002522:Chlorocebus aethiops; D039761:Genista / Q000737:chemistry*; D027522:Marrubium / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D014416:Tunisia; D014709:Vero Cells
chemical_list: D000890:Anti-Infective Agents; D010936:Plant Extracts