The efficacy of thermotherapy to treat cutaneous leishmaniasis in Colombia: a comparative observational study in an operational setting.
An open label, comparative study to compare the efficacy of thermotherapy to meglumine antimoniate in treating cutaneous leishmaniasis patients in an operational context was carried out in Chaparral, Colombia. After enrollment patients were followed-up for up to 100 days. Per protocol and intention-to-treat cure rates for 47 patients treated using thermotherapy (one-time 50 degrees C applications for 30s) were 100 and 19%, respectively. Per protocol and intention-to-treat cure rates for meglumine antimoniate (20 mg/kg body weight administered intramuscularly for 21 d) were 78 and 23%, respectively.
Vega
Juan Carlos
JC
Universidad Militar Nueva Granada, Santafé de Bogotá, Colombia.
Sanchez
Boris Fernando
BF
Montero
Luz Mery
LM
Montaña
Rafael
R
Mahecha
Mercedes del Pilar
Mdel P
Dueñes
Bladimir
B
Baron
Angela Rocío
AR
Reithinger
Richard
R
D000293:Adolescent; D000328:Adult; D000981:Antiprotozoal Agents / Q000191:economics / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003105:Colombia; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007223:Infant; D007231:Infant, Newborn; D016773:Leishmaniasis, Cutaneous / Q000175:diagnosis / Q000191:economics / Q000628:therapy*; D008297:Male; D008536:Meglumine / Q000191:economics / Q000627:therapeutic use*; D000077485:Meglumine Antimoniate; D009942:Organometallic Compounds / Q000191:economics / Q000627:therapeutic use*; D011446:Prospective Studies; D016896:Treatment Outcome; D055815:Young Adult
D000981:Antiprotozoal Agents; D009942:Organometallic Compounds; D008536:Meglumine; D000077485:Meglumine Antimoniate