Rational design of an optical adenosine sensor by conjugating a DNA aptamer with split DNAzyme halves.
Split halves of a hemin-binding DNAzyme have been assembled with an anti-adenosine aptamer to build a homogeneous allosteric sensor for adenosine with high selectivity and sensitivity.
Lu
Na
N
Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China.
Shao
Congying
C
Deng
Zhaoxiang
Z
D000241:Adenosine / Q000032:analysis* / Q000737:chemistry* / Q000378:metabolism; D052157:Aptamers, Nucleotide / Q000737:chemistry* / Q000378:metabolism*; D021881:DNA, Catalytic / Q000737:chemistry* / Q000378:metabolism*; D007700:Kinetics; D015394:Molecular Structure
D052157:Aptamers, Nucleotide; D021881:DNA, Catalytic; D000241:Adenosine