Thromboembolic disease in vasculitis.
OBJECTIVE
To give an overview of recent clinical findings of thromboembolic disease in vasculitis and provide insight into possible explanations of the association between thrombosis and inflammation.


RESULTS
A high incidence of venous thrombotic events has recently been described in four distinct cohorts of patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV), especially during periods of active disease. No factors other than the vasculitis itself have been identified that explain this high occurrence of thrombosis. Several studies have shown an increased rate of thrombosis in Behçet's disease, with a different clinical presentation from that observed in AAV. Recent laboratory findings provide exciting insights into a bidirectional feedback loop between coagulation and inflammation that may be applicable to vasculitis.


CONCLUSIONS
Thrombosis is an important clinical manifestation of some types of vasculitis. Better understanding of the association of thrombosis with inflammation in vasculitis might lead to development of clinically useful biomarkers and new approaches to therapy. Additionally, study of the specific factors involved in thrombosis in systemic vasculitis could help explain the role of inflammation in more common settings of venous thrombotic events.
Tomasson
Gunnar
G
The Vasculitis Center, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts 02118, USA.
Monach
Paul A
PA
Merkel
Peter A
PA
D001323:Autoantibodies / Q000276:immunology; D001528:Behcet Syndrome / Q000276:immunology; D015415:Biomarkers / Q000032:analysis; D001778:Blood Coagulation Disorders / Q000276:immunology* / Q000503:physiopathology* / Q000628:therapy; D003937:Diagnosis, Differential; D006801:Humans; D007167:Immunotherapy / Q000639:trends; D009504:Neutrophils / Q000276:immunology; D013923:Thromboembolism / Q000276:immunology* / Q000503:physiopathology* / Q000628:therapy; D014657:Vasculitis / Q000150:complications* / Q000276:immunology*
D001323:Autoantibodies; D015415:Biomarkers