Contribution of AZAP-Type Arf GAPs to cancer cell migration and invasion.
Arf GAPs are a family of proteins with a common catalytic domain that induces hydrolysis of GTP bound to the small GTP-binding protein Arf. The proteins are otherwise structurally diverse. Several subtypes of Arf GAPs have been found to be targets of oncogenes and to control cell proliferation and cell migration. The latter effects are thought to be mediated by coordinating changes in actin remodeling and membrane traffic. In this chapter, we discuss Arf GAPs that have been linked to oncogenesis and the molecular mechanisms underlying the effects of these proteins in cancer cells. We also discuss the enzymology of the Arf GAPs related to possible targeted inhibition of specific subtypes of Arf GAPs.
Ha
Vi Luan
VL
Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland, USA.
Luo
Ruibai
R
Nie
Zhongzhen
Z
Randazzo
Paul A
PA
D020727:ADP-Ribosylation Factors / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D002465:Cell Movement; D022001:Focal Adhesions; D020690:GTPase-Activating Proteins / Q000378:metabolism*; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008954:Models, Biological; D005810:Multigene Family; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000473:pathology*; D017434:Protein Structure, Tertiary; D015398:Signal Transduction
D020690:GTPase-Activating Proteins; D020727:ADP-Ribosylation Factors