A vanishing act, explained.
In a paper in this issue of Developmental Cell, Shibutani et al. (2008) uncover the mechanism that underlies tightly regulated S-phase degradation of Drosophila E2F1 during development. They show that dE2F1 is degraded by the Cul4(Cdt2) ubiquitin ligase in a manner that resembles the DNA replication-dependent turnover of Cdt1.
Korenjak
Michael
M
MGH Cancer Center, Charlestown, MA 02129, USA.
Dyson
Nicholas
N
D000818:Animals; D044842:Cullin Proteins / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D004261:DNA Replication; D004331:Drosophila melanogaster; D050687:E2F1 Transcription Factor / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D016160:Retinoblastoma Protein / Q000378:metabolism; D019089:Stem Cell Factor / Q000378:metabolism; D025801:Ubiquitin / Q000378:metabolism
C114234:CUL4A protein, human; D044842:Cullin Proteins; D050687:E2F1 Transcription Factor; D018809:Proliferating Cell Nuclear Antigen; D016160:Retinoblastoma Protein; D019089:Stem Cell Factor; D025801:Ubiquitin; D004247:DNA