Detection of isolated cerebrovascular beta-amyloid with Pittsburgh compound B.
Imaging of cerebrovascular beta-amyloid (cerebral amyloid angiopathy) is complicated by the nearly universal overlap of this pathology with Alzheimer's pathology. We performed positron emission tomographic imaging with Pittsburgh Compound B on 42-year-old man with early manifestations of Iowa-type hereditary cerebral amyloid angiopathy, a form of the disorder with little or no plaque deposits of fibrillar beta-amyloid. The results demonstrated increased Pittsburgh Compound B retention selectively in occipital cortex, sparing regions typically labeled in Alzheimer's disease. These results offer compelling evidence that Pittsburgh Compound B positron emission tomography can noninvasively detect isolated cerebral amyloid angiopathy before overt signs of tissue damage such as hemorrhage or white matter lesions.
Greenberg
Steven M
SM
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. sgreenberg@partners.org
Grabowski
Thomas
T
Gurol
M Edip
ME
Skehan
Maureen E
ME
Nandigam
R N Kaveer
RN
Becker
John A
JA
Garcia-Alloza
Monica
M
Prada
Claudia
C
Frosch
Matthew P
MP
Rosand
Jonathan
J
Viswanathan
Anand
A
Smith
Eric E
EE
Johnson
Keith A
KA
D000328:Adult; D016229:Amyloid beta-Peptides / Q000032:analysis*; D000814:Aniline Compounds; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000503:physiopathology; D001931:Brain Mapping / Q000379:methods; D016657:Cerebral Amyloid Angiopathy / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000503:physiopathology; D002536:Cerebral Arteries / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008297:Male; D009778:Occipital Lobe / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D058225:Plaque, Amyloid / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D049268:Positron-Emission Tomography / Q000379:methods; D011237:Predictive Value of Tests; D013844:Thiazoles
C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D016229:Amyloid beta-Peptides; D000814:Aniline Compounds; D013844:Thiazoles