Ser-His catalyses the formation of peptides and PNAs.
The dipeptide seryl-histidine (Ser-His) catalyses the condensation of esters of amino acids, peptide fragments, and peptide nucleic acid (PNA) building blocks, bringing to the formation of peptide bonds. Di-, tri- or tetra-peptides can be formed with yields that vary from 0.5% to 60% depending on the nature of the substrate and on the conditions. Other simpler peptides as Gly-Gly, or Gly-Gly-Gly are also effective, although less efficiently. We discuss the results from the viewpoint of primitive chemistry and the origin of long macromolecules by stepwise fragment condensations.
Gorlero
Maçha
M
Biology Department, University of RomaTre, Rome, Italy.
Wieczorek
Rafal
R
Adamala
Katarzyna
K
Giorgi
Alessandra
A
Schininà
Maria Eugenia
ME
Stano
Pasquale
P
Luisi
Pier Luigi
PL
D002384:Catalysis; D004151:Dipeptides / Q000737:chemistry*; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis*; D010455:Peptides / Q000138:chemical synthesis*
D004151:Dipeptides; D020135:Peptide Nucleic Acids; D010455:Peptides; C422849:seryl-histidine