title: Argon plasma coagulation with submucosal saline injection for gastric adenoma on outpatient basis.
abstract: Gastric adenoma with low-grade dysplasia (LGD) is a less progressive disease than with high-grade dysplasia; nevertheless, a certain portion of lesions can progress. The purpose of this study was to evaluate the effectiveness of argon plasma coagulation (APC) with submucosa saline injections (APC-SSI) for gastric adenoma with LGD on an outpatient department (OPD) basis. We included 57 patients with 64 lesions of gastric adenoma with LGD. Endoscopic type was flat elevated in 58 lesions and central depressed in 6 lesions. Normal saline was injected into the submucosa under the lesion before APC. APC was performed to the lesion and its surrounding mucosa. After treatment, patients underwent regular endoscopy follow-ups. One case each of pneumoperitoneum and Mallory-Weiss tearing occurred and could be managed with conservative care. One case of overt bleeding occurred after 2 weeks and was treated with APC. After 19.5 months of follow-up, four residual adenomas (6.3%) were found and treated with additional APC-SSI. Fourteen metachronous lesions were noted in eight patients (14.0%). Twelve lesions were adenoma with LGD and two lesions were intramucosal adenocarcinoma. APC-SSI is an effective and safe treatment modality for gastric adenoma with LGD on an OPD basis and it is recommended for patients with risk factors of endoscopic mucosal resection (EMR). After treatment of gastric adenoma, meticulous follow-up endoscopy is recommended for detection of metachronous lesions.
authors.affiliation: Department of Gastroenterology, Ajou University School of Medicine, San-5 Woncheon-dong, Yongtong-gu, Suwon 442-749, South Korea. lkm5104@ajou.ac.kr
authors.forename: Kee Myung
authors.initials: KM
authors.lastname: Lee
authors.forename: Young Bae
authors.initials: YB
authors.lastname: Kim
authors.forename: Sung Jae
authors.initials: SJ
authors.lastname: Sin
authors.forename: Jae Yeon
authors.initials: JY
authors.lastname: Jung
authors.forename: Jae Chul
authors.initials: JC
authors.lastname: Hwang
authors.forename: Sun Gyo
authors.initials: SG
authors.lastname: Lim
authors.forename: Byung Moo
authors.initials: BM
authors.lastname: Yoo
authors.forename: Jin Hong
authors.initials: JH
authors.lastname: Kim
authors.forename: Sung Won
authors.initials: SW
authors.lastname: Cho
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D000236:Adenoma / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000553:Ambulatory Care; D057908:Argon Plasma Coagulation / Q000009:adverse effects; D001706:Biopsy; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology / Q000601:surgery*; D005773:Gastroscopy; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D016609:Neoplasms, Second Primary; D056910:Republic of Korea; D012965:Sodium Chloride / Q000008:administration & dosage*; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D012965:Sodium Chloride