title: [Influence of mutations of proteinase-activated receptors F2R/PAR1 and F2RL1/PAR2 on inflammatory bowel disease].
abstract: OBJECTIVE
  Inflammatory bowel disease (IBD) is a polygenic complex trait. The expression and presence in biopsiae from IBD patients points to a putative role of these genes in genetic susceptibility to IBD. This is the first association study on these genes in relation with IBD.
  
  
  METHODS
  Two polymorphisms were analyzed within F2R/PAR1 and another one mapping to F2RL1/PAR2 in 778 healthy controls and 943 IBD cases (Crohn's disease and ulcerative colitis patients from 2 cohorts from Madrid and Granada).
  
  
  RESULTS
  No significant differences in the distribution of the PARs' polymorphisms were found.
  
  
  CONCLUSIONS
  There is no evidence of association of the analyzed polymorphisms with IBD risk.
authors.affiliation: Servicio de Inmunología Clínica, Hospital Clínico San Carlos, Madrid, España. cmartal@terra.es
authors.forename: M Carmen
authors.initials: MC
authors.lastname: Martín
authors.forename: Javier
authors.initials: J
authors.lastname: Oliver
authors.forename: Juan Luis
authors.initials: JL
authors.lastname: Mendoza
authors.forename: Miguel
authors.initials: M
authors.lastname: Fernández-Arquero
authors.forename: Javier
authors.initials: J
authors.lastname: Martín
authors.forename: Elena
authors.initials: E
authors.lastname: Urcelay
mesh_terms: D015331:Cohort Studies; D003093:Colitis, Ulcerative / Q000453:epidemiology / Q000235:genetics*; D003424:Crohn Disease / Q000453:epidemiology / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007438:Introns / Q000235:genetics; D015810:Linkage Disequilibrium; D016254:Mutagenesis, Insertional; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D044463:Receptor, PAR-1 / Q000235:genetics*; D018179:Receptors, Thrombin / Q000235:genetics*; D012306:Risk; D013030:Spain / Q000453:epidemiology
chemical_list: D044463:Receptor, PAR-1; D018179:Receptors, Thrombin; C105295:protease-activated receptor 3