Sulfamides as novel histone deacetylase inhibitors.
The sulfamide moiety has been utilized to design novel HDAC inhibitors. The potency and selectivity of these inhibitors were influenced both by the nature of the scaffold, and the capping group. Linear long-chain-based analogs were primarily HDAC6-selective, while analogs based on the lysine scaffold resulted in potent HDAC1 and HDAC6 inhibitors.
Wahhab
Amal
A
Department of Medicinal Chemistry, MethylGene Inc., 7220 rue Frederick-Banting, Montreal, Que., Canada H4S 2A1. wahhaba@methylgene.com
Smil
David
D
Ajamian
Alain
A
Allan
Martin
M
Chantigny
Yves
Y
Therrien
Eric
E
Nguyen
Natalie
N
Manku
Sukhdev
S
Leit
Silvana
S
Rahil
Jubrail
J
Petschner
Andrea J
AJ
Lu
Ai-Hua
AH
Nicolescu
Alina
A
Lefebvre
Sylvain
S
Montcalm
Samuel
S
Fournel
Marielle
M
Yan
Theresa P
TP
Li
Zuomei
Z
Besterman
Jeffrey M
JM
Déziel
Robert
R
D000577:Amides / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D056572:Histone Deacetylase Inhibitors
D000577:Amides; D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors