[Expression of integrin-beta1 in oral leukoplakia and early invasive carcinoma and its relationship with cell proliferation].
OBJECTIVE
To investigate the expression and significance of integrin-beta1 in oral leukoplakia and early invasive carcinoma.


METHODS
The expression of integrin-beta1 and Ki-67 was examined in 12 normal oral mucosa, 10 simple hyperplasia, 24 epithelial dysplasia and 14 early invasive carcinoma by immunohistochemistry.


RESULTS
In normal and simple hyperplasia epithelium, integrin-beta1 was mostly expressed in the basal cell membrane, and Ki-67 in the nuclei of basal and the parabasal layers. In dysplasia epithelium and early invasive carcinoma, integrin-beta1 showed membrane staining and Ki-67 showed nuclear staining in dysplastic basal cells, sprinkle cells and SCC cells. Integrin-beta1 and Ki-67 were overexpressed in 7 and 10 of 24 dysplasia cases and in 8 of 14 early invasive carcinoma cases respectively. There was a significant difference in integrin-beta1 and Ki-67 expression among the four groups (chi2 = 10.651, P = 0.014; chi2 = 14.831, P = 0.002), in integrin-beta1 expression among normal oral mucosa, simple hyperplasia and early invasive carcinoma (P = 0.008, P = 0.013) and in Ki-67 expression among normal oral mucosa and dysplasia, early invasive carcinoma (P = 0.026, P = 0.001), and among simple hyperplasia and early invasive carcinoma (P = 0.005). A significant correlation between integrin-beta1 and Ki-67 (R = 0.442, P < 0.01) was found.


CONCLUSIONS
Integrin-beta1 showed increased staining in dysplasia epithelium cells and SCC cells, and may correlate to the proliferation of the dysplasia cells.
Shang
Jian-wei
JW
Department of Oral Pathology, Peking University School and Hospital of Stomatology, Beijing 100081, China.
Gao
Yan
Y
D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology; D049109:Cell Proliferation; D006801:Humans; D019012:Integrin beta1 / Q000378:metabolism*; D019394:Ki-67 Antigen / Q000378:metabolism; D007972:Leukoplakia, Oral / Q000378:metabolism* / Q000473:pathology*; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology*
D019012:Integrin beta1; D019394:Ki-67 Antigen