Can intracytoplasmic morphologically selected sperm injection be used to select normal-sized sperm heads in infertile patients with macrocephalic sperm head syndrome?
OBJECTIVE
To study the chromosomal content of spermatozoa selected by intracytoplasmic morphologically selected sperm injection (IMSI) in cases of macrocephalic sperm head syndrome.


METHODS
Case report.


METHODS
Obstetrics, gynecology, urology, and reproductive biology departments.


METHODS
Two infertile patients with large-headed spermatozoa.


METHODS
Fluorescence in situ hybridization on selected spermatozoa with normal-sized heads after IMSI selection.


METHODS
Percentages of polyploid, diploid, haploid aneuploid, and normal spermatozoa.


RESULTS
Of the six spermatozoa that could be selected, all were haploid but aneuploid.


CONCLUSIONS
Absence of normal haploid spermatozoa among high magnification-selected spermatozoa contraindicated IMSI for these two patients.
Chelli
Mohamed Hassen
MH
Department of Reproductive Biology and Cytogenetics, Centre Hospitalier Poissy, Saint Germain, France.
Albert
Martine
M
Ray
Pierre F
PF
Guthauser
Bruno
B
Izard
Vincent
V
Hammoud
Ibrahim
I
Selva
Jacqueline
J
Vialard
François
F
D000782:Aneuploidy; D053713:Azoospermia / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D006801:Humans; D007248:Infertility, Male / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy*; D008297:Male; D013077:Sperm Head / Q000502:physiology*; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods*; D013094:Spermatozoa / Q000002:abnormalities / Q000502:physiology; D013577:Syndrome