Transforming growth factor-beta signaling in skin: stromal to epithelial cross-talk.
In this issue, Denton et al., describe a mouse model of postnatal deletion of the transforming growth factor (TGF)-beta receptor type II (TbetaRII) in skin fibroblasts. Using a tamoxifen-dependent inducible Cre-lox strategy, the authors demonstrate the pivotal role played by TGF-beta signaling in fibroblasts during wound healing. Healing of full-thickness wounds after fibroblast-specific deletion of TbetaRII in the skin was severely impaired and exhibited delayed re-epithelialization. This study emphasizes the importance of fibroblasts in mesenchymal-epithelial interaction in the skin during wound repair.
Mauviel
Alain
A
INSERM U697, Hôpital Saint-Louis, Paris, France. alain.mauviel@inserm.fr
D000818:Animals; D004848:Epithelium / Q000378:metabolism*; D005347:Fibroblasts / Q000378:metabolism; D017353:Gene Deletion; D006801:Humans; D051379:Mice; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism; D015398:Signal Transduction; D012867:Skin / Q000378:metabolism*; D017154:Stromal Cells / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D014945:Wound Healing
D016212:Transforming Growth Factor beta