title: Advanced oxidative protein products are independently associated with endothelial function in peritoneal dialysis patients.
abstract: OBJECTIVE
  Oxidative stress (OS) and asymmetric dimethylarginine (ADMA) are accepted as non-classical cardiovascular risk factors in end-stage renal disease patients. To clarify the role of these factors in the atherosclerotic process, we investigated if OS and ADMA are associated with endothelial function (EF) in peritoneal dialysis (PD) patients.
  
  
  METHODS
  Fifty-two non-diabetic PD patients without known atherosclerotic disease as well as 30 age- and sex-matched healthy individuals were included. We measured serum thiobarbituric acid-reactive substances (TBARS), malondialdehyde (MDA), advanced glycation end-product (AGE), pentosidine, advanced oxidation protein products (AOPP), ADMA and EF as described by Celermejer et al. in all subjects.
  
  
  RESULTS
  TBARS, MDA, AOPP, AGE, pentosidine and ADMA levels were significantly higher in PD patients than in controls (P < 0.001). Flow-mediated dilatation (FMD)% and nitrate mediated dilatation (NMD)% in PD patients were lower than in the control group (7.7 +/- 4.0% vs 11.70 +/- 5.50%, P < 0.01 and 17.6 +/- 8.3% vs 26.4 +/- 4.6%, P < 0.01). Additionally, it was found that AOPP are independently correlated with FMD% and NMD% in PD patients (beta = -463, P < 0.01 and beta = -420, P < 0.05).
  
  
  CONCLUSIONS
  This study shows that PD patients without known atherosclerotic disease can also be characterized by endothelial dysfunction and AOPP levels independently predict endothelial function level in PD patients.
authors.affiliation: Division of Nephrology, Faculty of Medicine, Akdeniz University, Antalya, Turkey. hkocak@akdeniz.edu.tr
authors.forename: Huseyin
authors.initials: H
authors.lastname: Kocak
authors.forename: Saadet
authors.initials: S
authors.lastname: Gumuslu
authors.forename: Emel
authors.initials: E
authors.lastname: Sahin
authors.forename: Kaan
authors.initials: K
authors.lastname: Ceken
authors.forename: Yesim A
authors.initials: YA
authors.lastname: Gocmen
authors.forename: Gulsen
authors.initials: G
authors.lastname: Yakupoglu
authors.forename: F Fevzi
authors.initials: FF
authors.lastname: Ersoy
authors.forename: Murat
authors.initials: M
authors.lastname: Tuncer
mesh_terms: D000328:Adult; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D003430:Cross-Sectional Studies; D004730:Endothelium, Vascular / Q000502:physiology*; D005260:Female; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D010530:Peritoneal Dialysis; D012044:Regression Analysis
chemical_list: D017127:Glycation End Products, Advanced; C018524:N,N-dimethylarginine; D001120:Arginine