title: Nicotine and Delta(9)-tetrahydrocannabinol withdrawal induce Narp in the central nucleus of the amygdala.
abstract: The central nucleus of the amygdala plays a key role in mediating aversive responses to drug withdrawal, effects thought to contribute to continued drug use. In previous studies, we found that the immediate early gene Narp, which encodes a secreted protein that binds to AMPA receptors, is induced in this nucleus following opiate withdrawal. Furthermore, Narp deletion alters the acquisition and extinction of aversive conditioning induced by opiate withdrawal. We now report that Narp is also induced in the central nucleus following withdrawal from other drugs of abuse, nicotine and Delta(9)-tetrahydrocannabinol, indicating that Narp is a common component of the transcriptional response triggered by drug withdrawal.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University, 600 N. Wolfe Street, Baltimore, MD 21205, USA. ireti1@jhmi.edu
authors.forename: Irving M
authors.initials: IM
authors.lastname: Reti
authors.forename: Sungho
authors.initials: S
authors.lastname: Han
authors.forename: Matthew
authors.initials: M
authors.lastname: Miskimon
authors.forename: Jeffrey B
authors.initials: JB
authors.lastname: Rosen
authors.forename: Jay M
authors.initials: JM
authors.lastname: Baraban
mesh_terms: D000679:Amygdala / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D002097:C-Reactive Protein / Q000378:metabolism*; D002452:Cell Count / Q000379:methods; D013759:Dronabinol / Q000009:adverse effects*; D008297:Male; D009025:Morpholines / Q000494:pharmacology; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects; D009538:Nicotine / Q000009:adverse effects*; D011720:Pyrazoles / Q000494:pharmacology; D051381:Rats; D013315:Stress, Psychological / Q000378:metabolism; D013375:Substance Withdrawal Syndrome / Q000473:pathology*; D000099153:Pentraxins
chemical_list: D002097:C-Reactive Protein; D013759:Dronabinol; D009025:Morpholines; D009419:Nerve Tissue Proteins; D009538:Nicotine; D011720:Pyrazoles; D000099153:Pentraxins; C109925:AM 281