Factor structure of planning and problem-solving: a behavioral genetic analysis of the Tower of London task in middle-aged twins.
We examined the genetic architecture of a Tower of London test of planning and problem-solving in 690 middle-aged male twins. Phenotypic analyses revealed only one general factor, but the best-fitting genetic model indicated two correlated genetic factors: speed and efficiency. One variable-number of attempts required to mentally figure the puzzles-loaded on both factors. Shared environmental effects could be dropped with virtually no reduction in model fit. Despite significant nonshared environmental correlations across measures, there was no discernable nonshared environmental factor structure. The correlation between genetic factors (r = 0.46) and the variable loading on both factors could reflect modulation of planning, testing alternatives, and working memory that are required to perform the test. Such coordinated activity is consistent with the notion of a supervisory attentional system, a central executive, or metacognitive ability. The different phenotypic and genetic factor results suggest that relying solely on the former could obscure genetic associations.
Kremen
William S
WS
Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, La Jolla, CA 92093-0738, USA. wkremen@ucsd.edu
Jacobson
Kristen C
KC
Panizzon
Matthew S
MS
Xian
Hong
H
Eaves
Lindon J
LJ
Eisen
Seth A
SA
Tsuang
Ming T
MT
Lyons
Michael J
MJ
D000328:Adult; D000375:Aging; D001288:Attention; D001519:Behavior; D003071:Cognition; D004777:Environment; D006801:Humans; D008297:Male; D008568:Memory; D008875:Middle Aged; D009483:Neuropsychological Tests; D010641:Phenotype; D011340:Problem Solving; D014427:Twins / Q000235:genetics / Q000523:psychology; D018910:Video Games