Use of (1)H NMR to facilitate solubility measurement for drug discovery compounds.
The use of (1)H NMR experiments to determine the solubility of potential drug candidates using a panel of solubilizing agents is proposed as an alternative to an HPLC-UV method. The advantages of using this approach will be discussed and results comparing the two methodologies will be presented. This effort highlights the importance of a simple method for determining a suitable formulation for discovery compounds for studies using a minimal amount of material in support of early in vivo studies.
Lin
Melissa
M
Chemical and Screening Sciences, Discovery Analytical Chemistry, Wyeth Research, Pearl River, NY 10965, United States.
Tesconi
Marc
M
Tischler
Mark
M
D002626:Chemistry, Pharmaceutical / Q000379:methods; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D015195:Drug Design; D005079:Excipients / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet / Q000379:methods
D005079:Excipients; D004364:Pharmaceutical Preparations