Cespihypotins Q-V, verticillene diterpenoids from Cespitularia hypotentaculata.
Chemical investigation of the soft coral Cespitularia hypotentaculata resulted in the isolation of six new diterpenes, cespihypotins Q-V. The new metabolites comprised five verticillane-type diterpenes and one nor-verticillane derivative. Their structures were determined through detailed spectroscopic analyses, especially HRESIMS and 2D NMR techniques. The relative configuration was deduced by interpretation of NOESY spectra. Cespihypotin T exhibited significant cytotoxic activity against human Daoy and WiDr tumor cell lines.
Shen
Ya-Ching
YC
School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Road, Sec. 1, Taipei 100, Taiwan, Republic of China. ycshen@ntu.edu.tw
Lo
Kuang-Liang
KL
Kuo
Yao-Haur
YH
Kuo
Yuh-Chi
YC
Chen
Chung-Hsiung
CH
Khalil
Ashraf T
AT
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure
D000970:Antineoplastic Agents; D004224:Diterpenes; C534405:cespihypotin T