Antifungal unsaturated cyclic Mannich ketones and amino alcohols: study of mechanism of action.
The antifungal activity of some known unsaturated Mannich ketones and their amino alcohols has been reported and the mechanism of antifungal action has been studied. The inhibition of the fungal ergosterol, chitin, protein synthesis and pseudohypha formation was investigated. According to our results, Mannich ketones can influence the development of pseudohyphae of Candida albicans strains. In addition, they are able to induce significant changes in the protein composition of this fungal strain. Some of our Mannich ketones have shown inhibitory effect on the fungal chitin synthase enzyme. QSAR studies were also carried out.
Kocsis
Béla
B
University of Pécs, Faculty of Medicine, Department of Medical Microbiology and Immunology, H-7624 Pécs, Szigeti út 12, Hungary.
Kustos
Ildikó
I
Kilár
Ferenc
F
Nyul
Adrien
A
Jakus
Péter B
PB
Kerekes
Szilárd
S
Villarreal
Victor
V
Prókai
László
L
Lóránd
Tamás
T
D000605:Amino Alcohols / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D002176:Candida albicans; D002686:Chitin / Q000096:biosynthesis; D002687:Chitin Synthase / Q000187:drug effects; D004875:Ergosterol / Q000096:biosynthesis; D025301:Hyphae / Q000187:drug effects; D007659:Ketones / Q000737:chemistry / Q000494:pharmacology; D014176:Protein Biosynthesis / Q000187:drug effects; D021281:Quantitative Structure-Activity Relationship
D000605:Amino Alcohols; D000935:Antifungal Agents; D007659:Ketones; D002686:Chitin; D002687:Chitin Synthase; D004875:Ergosterol