title: New sequence variants associated with bone mineral density.
abstract: In an extended genome-wide association study of bone mineral density among 6,865 Icelanders and a follow-up in 8,510 subjects of European descent, we identified four new genome-wide significant loci. These are near the SOST gene at 17q21, the MARK3 gene at 14q32, the SP7 gene at 12q13 and the TNFRSF11A (RANK) gene at 18q21. Furthermore, nonsynonymous SNPs in the C17orf53, LRP4, ADAM19 and IBSP genes were suggestively associated with bone density.
authors.affiliation: deCODE Genetics, Reykjavik, Iceland. unnur.styrkarsdottir@decode.is
authors.forename: Unnur
authors.initials: U
authors.lastname: Styrkarsdottir
authors.forename: Bjarni V
authors.initials: BV
authors.lastname: Halldorsson
authors.forename: Solveig
authors.initials: S
authors.lastname: Gretarsdottir
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Gudbjartsson
authors.forename: G Bragi
authors.initials: GB
authors.lastname: Walters
authors.forename: Thorvaldur
authors.initials: T
authors.lastname: Ingvarsson
authors.forename: Thorbjorg
authors.initials: T
authors.lastname: Jonsdottir
authors.forename: Jona
authors.initials: J
authors.lastname: Saemundsdottir
authors.forename: Steinunn
authors.initials: S
authors.lastname: Snorradóttir
authors.forename: Jacqueline R
authors.initials: JR
authors.lastname: Center
authors.forename: Tuan V
authors.initials: TV
authors.lastname: Nguyen
authors.forename: Peter
authors.initials: P
authors.lastname: Alexandersen
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Gulcher
authors.forename: John A
authors.initials: JA
authors.lastname: Eisman
authors.forename: Claus
authors.initials: C
authors.lastname: Christiansen
authors.forename: Gunnar
authors.initials: G
authors.lastname: Sigurdsson
authors.forename: Augustine
authors.initials: A
authors.lastname: Kong
authors.forename: Unnur
authors.initials: U
authors.lastname: Thorsteinsdottir
authors.forename: Kari
authors.initials: K
authors.lastname: Stefansson
mesh_terms: D001483:Base Sequence; D015519:Bone Density / Q000235:genetics*; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics; D005260:Female; D050723:Fractures, Bone / Q000150:complications / Q000235:genetics; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D014947:Wounds and Injuries / Q000150:complications / Q000235:genetics