[Determine and parallel analysis of three kinds of PAEs in serum for obese children].
OBJECTIVE
To study the serum contents of the PAEs of obese children at the ages of 10 to 12 years, in order to estimate the harm of PAEs on obese children.


METHODS
The contents of three kinds PAEs(DEP, DBP and DEHP) in the serum for two groups of children, including 36 obese children and 36 normal weight children, were determined by the reversed phase high performance liquid chromatography (RP-HPLC) method And the average measure value of three kind PAEs between two groups of children were analysed.


RESULTS
The median serum levels of PAEs were 0.0032 (DEP), 0.1649 (DBP) and 0.1680 (DEHP) in obese children. And the serum levels of PAEs were 0.0026 (DEP), 0.0359 (DBP) and 0.1063 (DEHP) in normal weight children. The differences of average measure value of DBP and DEHP in three kind PAEs between two groups of children were significant (P < 0.01). The amounts of obese children in high level were more than those of normal weight children, and the constitution ratios in three kinds of PAEs of obese children were higher than those of normal weight children. The differences between two groups of children were significant (P < 0.01).


CONCLUSIONS
The average levels of DBP and DEHP in serum of obese children were more than those of serum of normal weight children. The amounts of obese children were higher than those of normal weight children in high level content of three kinds of PAEs.
Li
Ping
P
School of Public Health, Chongqing University of Medical Sciences, Chongqing 400016, China.
Dai
Xingbi
X
Dan
Hong
H
Huang
Xiaohong
X
D016022:Case-Control Studies; D002648:Child; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003993:Dibutyl Phthalate / Q000097:blood*; D004051:Diethylhexyl Phthalate / Q000097:blood*; D004952:Esters / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000097:blood*; D010795:Phthalic Acids / Q000097:blood*
D004952:Esters; D010795:Phthalic Acids; C024629:dimethyl phthalate; D003993:Dibutyl Phthalate; D004051:Diethylhexyl Phthalate