title: Studies with beta-oxoalkanonitriles: simple novel synthesis of 3-[2,6-diaryl-4- pyridyl]-3-oxopropanenitriles.
abstract: Heteroaromatization of ethyl 2-cyano-4-oxo-2-(2-oxo-2-arylethyl)-4-arylbutanoates 3a,b with ammonium acetate gave ethyl 2,6-diarylisonicotinates 4a,b. Treatment of the latter with acetonitrile afforded novel beta-oxoalkanonitriles 6a,b. Reactions of 6a,b with phenyl hydrazine and hydroxylamine gave the corresponding pyridyl aminopyrazoles 8a,b and pyridyl aminoisoxazoles 10a,b, respectively.
authors.affiliation: Department of Chemistry, Faculty of Science, Cairo University, Giza-12613- Egypt. riyadh1993@hotmail.com
authors.forename: Sayed M
authors.initials: SM
authors.lastname: Riyadh
authors.forename: Hamad M
authors.initials: HM
authors.lastname: Al-Matar
authors.forename: Mohamed H
authors.initials: MH
authors.lastname: Elnagdi
mesh_terms: D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry; D009584:Nitrogen / Q000737:chemistry
chemical_list: D009570:Nitriles; D009584:Nitrogen