[Immunomodulating, hepatoprotective and antioxidant activity of immobilized forms of aminoglycoside antibiotics in toxic damage to the kidneys complicated with staphylococcal infection].
Investigation of the influence of aminoglycoside antibiotics included into erythrocytes and leukocytes on the development of immune response and intensity of oxidative and hepatotoxic processes in experimental kidney pathology complicated with staphylococcal infection was made on Wistar rats. Erythrocyte and leukocyte carriers of amikacin and gentamycin were obtained. Spectrophotometric assay of the immobilized antibiotics was developed. It is shown that introduction of the free antibiotics enhanced immunosuppression, pro-oxidant and hepatotoxic effects induced by introduction of mercury dichloride and staphylococcus while antibiotics in erythrocytic and leukocytic carriers stabilized and normalized parameters characterizing renal excretion activity, immune system function, energetic and oxidative processes in erythrocytes, cholestasis and cytolysis processes in toxic pathology of the kidneys combined with staphylococcal infection.
Bratchikov
O I
OI
Lazarev
A I
AI
Siplivyĭ
G V
GV
Kukurekova
A V
AV
Shumakova
E A
EA
Siplivaia
L E
LE
D000617:Aminoglycosides / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D004912:Erythrocytes / Q000276:immunology / Q000473:pathology; D007155:Immunologic Factors / Q000494:pharmacology*; D007674:Kidney Diseases / Q000139:chemically induced / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D007962:Leukocytes / Q000276:immunology / Q000473:pathology; D008099:Liver / Q000276:immunology / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects* / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000276:immunology* / Q000382:microbiology / Q000473:pathology
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000975:Antioxidants; D007155:Immunologic Factors