title: Antimicrobial activities of jadomycin B and structurally related analogues.
abstract: Natural products are leads for new antibiotics as a result of their structural complexity and diversity. We have isolated a series of structurally related polyketide-derived natural products from Streptomyces venezuelae ISP5230. The most active of these jadomycin analogues showed good activity against a variety of staphylococci, including methicillin-resistant Staphylococcus aureus.
authors.affiliation: College of Pharmacy, Dalhousie University, Halifax, Nova Scotia, Canada. david.jakeman@dal.ca
authors.forename: David L
authors.initials: DL
authors.lastname: Jakeman
authors.forename: Srinivasulu
authors.initials: S
authors.lastname: Bandi
authors.forename: Cathy L
authors.initials: CL
authors.lastname: Graham
authors.forename: Taryn R
authors.initials: TR
authors.lastname: Reid
authors.forename: Jason R
authors.initials: JR
authors.lastname: Wentzell
authors.forename: Susan E
authors.initials: SE
authors.lastname: Douglas
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D007546:Isoquinolines / Q000737:chemistry / Q000494:pharmacology; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013212:Staphylococcus epidermidis / Q000187:drug effects; D013302:Streptomyces / Q000187:drug effects* / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D007546:Isoquinolines; C081750:jadomycin B