The intimate and mysterious relationship between proton channels and NADPH oxidase.
Voltage gated proton channels and NADPH oxidase function cooperatively in phagocytes during the respiratory burst, when reactive oxygen species are produced to kill microbial invaders. Although these molecules are distinct entities, with no proven physical interaction, their presence and activity in many cells appears to be coordinated. We describe these interactions and discuss several types of mechanisms that might explain them.
Musset
Boris
B
Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, IL 60612, USA. Boris_Musset@rsh.net
Cherny
Vladimir V
VV
Morgan
Deri
D
DeCoursey
Thomas E
TE
D000818:Animals; D006801:Humans; D015640:Ion Channel Gating; D007473:Ion Channels / Q000378:metabolism*; D051379:Mice; D019255:NADPH Oxidases / Q000378:metabolism*; D010586:Phagocytes / Q000378:metabolism* / Q000382:microbiology; D011522:Protons; D017382:Reactive Oxygen Species
D007473:Ion Channels; D011522:Protons; D017382:Reactive Oxygen Species; D019255:NADPH Oxidases