title: Peri-operative use of paracetamol.
abstract: This article is a review of the peri-operative use of paracetamol. It reviews the pharmacology of paracetamol, highlighting new information about the mechanism of action, and examines its therapeutic use in the peri-operative period, focusing on efficacy, route of administration, and the use of a loading dose to improve early postoperative analgesia.
authors.affiliation: South West School of Anaesthesia, Department of Anaesthetics, Royal Cornwall Hospital, Truro TR13LJ, UK. chrisoscier@hotmail.com
authors.forename: C D
authors.initials: CD
authors.lastname: Oscier
authors.forename: Q J W
authors.initials: QJ
authors.lastname: Milner
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D004333:Drug Administration Routes; D004334:Drug Administration Schedule; D006801:Humans; D010149:Postoperative Pain / Q000517:prevention & control*; D011182:Postoperative Care / Q000379:methods
chemical_list: D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen