Correlates of antioxidant nutrients and oxidative DNA damage differ by race in a cross-sectional study of healthy African American and white adults.
Although antioxidant nutrients and oxidative DNA damage have been associated with carcinogenesis, few studies have investigated the factors that influence antioxidant intake and oxidative DNA damage in racially diverse populations. Demographic, behavioral, and diet-related psychosocial correlates of plasma antioxidant (carotenoids, vitamin C, and vitamin E) concentrations and oxidative DNA damage were examined using data from a cross-sectional study of 147 generally healthy, nonsmoking African American and white adults in North Carolina, aged 20 to 45 years. All participants completed self-administered demographic, diet, and health questionnaires and provided semifasting (> or = 6 hours) blood samples. Multivariate regression analyses were computed separately for each race to determine associations between the potential correlates with plasma antioxidant concentrations and oxidative DNA damage, separately. Our findings suggest appreciable differences by race. Only a few factors (age, supplement use, and several psychosocial factors) were associated with antioxidant concentrations in African Americans, whereas these and additional factors, including physical activity, waist circumference, and passive smoke exposure, were associated with antioxidant concentrations in whites. For oxidative DNA damage, passive smoke exposure was significantly associated with oxidative DNA damage in African Americans, and age and alcohol were significant in whites. In addition, the regression models generally explained more of the variance in plasma antioxidant concentrations and oxidative DNA damage in whites than in African Americans. Considering the salient correlates differed by race, this work has important implications for the design and implementation of future research studies investigating antioxidant nutrients and/or oxidative stress, especially those in racially diverse populations.
Watters
Joanne L
JL
Cancer Prevention Fellowship Program, Office of Preventive Oncology, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20852, USA. wattersj@mail.nih.gov
Satia
Jessie A
JA
Kupper
Lawrence L
LL
D000328:Adult; D001741:Black or African American; D000428:Alcohol Drinking; D000975:Antioxidants / Q000008:administration & dosage* / Q000032:analysis; D001205:Ascorbic Acid / Q000097:blood; D002338:Carotenoids / Q000097:blood; D003430:Cross-Sectional Studies; D004249:DNA Damage; D004032:Diet; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D012044:Regression Analysis; D014028:Tobacco Smoke Pollution; D014810:Vitamin E / Q000097:blood; D044465:White People
D000975:Antioxidants; D014028:Tobacco Smoke Pollution; D014810:Vitamin E; D002338:Carotenoids; D001205:Ascorbic Acid