Developmentally degraded cortical temporal processing restored by training.
Enduring deficits in temporal processing can be induced in the auditory cortex by rearing infant rats in the presence of low frequency-modulated noises. We found that it was possible to restore normal temporal processing, overcoming deficits induced during the critical period, by intensively training developmentally impaired animals as juveniles or young adults. Re-normalized cortical temporal response characteristics were sustained long after training cessation.
Zhou
Xiaoming
X
School of Life Sciences, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, China. xmzhou@bio.ecnu.edu.cn
Merzenich
Michael M
MM
D000161:Acoustic Stimulation; D000822:Animal Husbandry; D000818:Animals; D000831:Animals, Newborn; D001303:Auditory Cortex / Q000254:growth & development / Q000503:physiopathology*; D003423:Critical Period, Psychological; D009622:Noise; D010468:Perceptual Disorders / Q000209:etiology / Q000503:physiopathology*; D051381:Rats; D013998:Time Perception