title: Genetic polymorphisms of 16 Y chromosomal STR loci in Korean population.
abstract: Allele frequencies and haplotypes of 16 Y chromosomal STR loci included in the AmpFlSTR((R)) Yfilertrade mark system were obtained from a sample of 526 unrelated Korean male individuals. A total of 478 haplotypes were observed in the 526 individuals studied, of which 440 were unique. The overall haplotype diversity for the 16 Y-STR loci was 0.9996, and the discrimination capacity was 0.9087. We found 13 atypical alleles, including null, duplicated and microvariant alleles. Microvariants have been characterized by sequencing, 14.1 allele at DYS458 showing the flanking site mutation, 13.1 and 15.2 allele at DYS385a/b showing changes in the repeat structure.
authors.affiliation: DNA Analysis Division, National Institute of Scientific Investigation, Seoul, Republic of Korea.
authors.forename: Soon Hee
authors.initials: SH
authors.lastname: Kim
authors.forename: Nam Ye
authors.initials: NY
authors.lastname: Kim
authors.forename: Seung Beom
authors.initials: SB
authors.lastname: Hong
authors.forename: Nam Soo
authors.initials: NS
authors.lastname: Cho
authors.forename: Jong Jin
authors.initials: JJ
authors.lastname: Kim
authors.forename: Myun Soo
authors.initials: MS
authors.lastname: Han
authors.forename: Won
authors.initials: W
authors.lastname: Kim
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D041322:Chromosomes, Human, Y; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D016172:DNA Fingerprinting / Q000379:methods; D005787:Gene Frequency; D005819:Genetic Markers; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007723:Korea; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D021141:Nucleic Acid Amplification Techniques; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D044382:Population Groups / Q000235:genetics*; D011786:Quality Control
chemical_list: D005819:Genetic Markers; D004247:DNA