title: [Malignant multiple neoplasms in head and neck squamous cell carcinoma].
abstract: BACKGROUND
  The incidence of multiple malignant neoplasms in the upper aerodigestive tract is high and ranges from 7% to 20%. We make a retrospective study to evaluate the incidence of multiple malignant neoplasms in head and neck squamous cell carcinomas, their main characteristics and survival.
  
  
  METHODS
  We studied 103 multiple malignant neoplasms from an oncological database of 1330 patients with head and neck squamous cell carcinomas. We use the SPSS v15 for analysis of the results.
  
  
  RESULTS
  The incidence of multiple malignant neoplasms in our series is 7.73 %. Tumours of the hypopharynx are the primary tumours most often associated with multiple malignant neoplasms (21.34 %), followed by tumours of the oropharynx (15.38 %). Lung tumours are the multiple malignant neoplasms most often associated (29.03 %). The 5-year global survival is 33 % from diagnosis of the second primary tumour, 78.02 % of which are metachronous with an average of 40 months between the diagnosis of the primary tumour and the presentation of the second tumour.
  
  
  CONCLUSIONS
  Multiple malignant neoplasms are very frequent in the head and neck area which shows the importance of thorough regular check-ups of these patients as the presence of multiple malignant neoplasms considerably worsens the prognosis.
authors.affiliation: Servicio de Otorrinolaringología, Hospital Universitario Dr. Peset, Valencia, España. celia.lopez.molla@gmail.com
authors.forename: Celia
authors.initials: C
authors.lastname: López Mollá
authors.forename: Enrique
authors.initials: E
authors.lastname: Estellés Ferriol
authors.forename: Marina
authors.initials: M
authors.lastname: Carrasco Llatas
authors.forename: Teresa
authors.initials: T
authors.lastname: Seijas Rosales
authors.forename: María
authors.initials: M
authors.lastname: Morales Suárez-Varela
authors.forename: José
authors.initials: J
authors.lastname: Dalmau Galofre
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary; D012189:Retrospective Studies