Effect of estradiol on oocyte development.
OBJECTIVE
To determine whether elevated serum estradiol (E(2)) concentrations in oocyte donors affect assisted reproduction outcome.


METHODS
In a retrospective cohort study of 58 consecutive oocyte donation cycles, donors were stratified into 2 groups according to E(2) concentration, group 1 (n=32; E(2)<or=2000 pg/mL [range 456-2000 pg/mL]) and group 2 (n=27; E(2)>2000 pg/mL [range, 2062-6957 pg/mL]). Data were analyzed using the t test and chi(2) test.


RESULTS
Donors in group 1 produced significantly less oocytes than donors in group 2 (19.3+/-1.7 vs 12.0+/-1.4; P<0.001), and recipients of oocytes from group 1 had significantly fewer numbers of embryos available for transfer (10.4+/-1.1 vs 6.4+/-0.8; P=0.003). However, the mean number (3.3) of embryos transferred and the pregnancy rate were the same in both groups.


CONCLUSIONS
Elevated estradiol concentration in oocyte donors did not affect pregnancy outcome, suggesting that estradiol levels in donors do not affect oocyte development.
Bianco
Katherine
K
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California 94143, USA. biancok@obgyn.ucsf.edu
Mahutte
Neal G
NG
Arici
Aydin
A
Sakkas
Denny
D
Taylor
Hugh S
HS
D000328:Adult; D015331:Cohort Studies; D004624:Embryo Transfer; D004622:Embryo, Mammalian; D004717:Endometrium / Q000502:physiology*; D004958:Estradiol / Q000097:blood*; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D008875:Middle Aged; D018587:Oocyte Donation; D009865:Oocytes / Q000502:physiology*; D009866:Oogenesis; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies
D004958:Estradiol; D005640:Follicle Stimulating Hormone