Characterization of enterocin- and salivaricin-producing lactic acid bacteria from the mammalian gastrointestinal tract.
Bacteriocin production may be a factor contributing to bacterial dominance within complex microbial populations and may therefore be a common trait within the gut microbiota. However, of 278 antimicrobial-producing culturable lactic acid bacteria (LAB) isolated from a range of mammalian intestinal sources in this study, characterization revealed just 23 distinct strains producing bacteriocin-like inhibitory substances and one Streptococcus hyointestinalis strain producing a potentially novel protease-insensitive antimicrobial. Three class II bacteriocins previously isolated from intestinal-derived LAB were identified as enterocin A and two salivaricin P-like bacteriocins. Moreover, this is the first report of intestinal-derived Streptococcus salivarius producing variants of the lantibiotic salivaricin A.
O'Shea
Eileen F
EF
Biotechnology Department, Teagasc, Moorepark Food Research Centre, Fermoy, Cork, Ireland.
Gardiner
Gillian E
GE
O'Connor
Paula M
PM
Mills
Susan
S
Ross
R Paul
RP
Hill
Colin
C
D000328:Adult; D000818:Animals; D001419:Bacteria / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D001430:Bacteriocins / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D002417:Cattle; D005260:Female; D041981:Gastrointestinal Tract / Q000382:microbiology*; D006801:Humans; D007231:Infant, Newborn; D019344:Lactic Acid / Q000378:metabolism*; D008297:Male; D008322:Mammals / Q000382:microbiology*; D008875:Middle Aged; D013552:Swine
D001426:Bacterial Proteins; D001430:Bacteriocins; C107799:enterocin A; C082674:salivaricin A; D019344:Lactic Acid