title: Familial Zenker's diverticulum.
abstract: CONCLUSIONS
  The aetiology of Zenker's diverticulum is likely to be multifactorial. The geographical and racial variation in the prevalence and the rare familial cases suggest that genetic predisposition might have a role in the pathogenesis. The mode of inheritance in the rare possible familial cases seems to be autosomal dominant; recessive inheritance is non-existent or extremely rare.
  
  
  OBJECTIVE
  To study the inheritance of Zenker's diverticulum.
  
  
  METHODS
  A detailed questionnaire concerning physical health and family history was sent to 122 patients with Zenker's diverticulum.
  
  
  RESULTS
  The prevalence of familial disease in Finland was found to be < 2%. We found no evidence for genetic founder effect.
authors.affiliation: Department of Otorhinolaryngology, Kymenlaakso Central Hospital, Kotka, Finland. tuomas.klockars@fimnet.fi
authors.forename: Tuomas
authors.initials: T
authors.lastname: Klockars
authors.forename: Eero
authors.initials: E
authors.lastname: Sihvo
authors.forename: Antti
authors.initials: A
authors.lastname: Mäkitie
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016000:Cluster Analysis; D005260:Female; D005387:Finland / Q000453:epidemiology; D020022:Genetic Predisposition to Disease; D006801:Humans; D040582:Inheritance Patterns / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D015995:Prevalence; D012111:Residence Characteristics; D016672:Zenker Diverticulum / Q000150:complications / Q000453:epidemiology* / Q000235:genetics*