title: Effects of electric field stress on a beta-amyloid peptide.
abstract: The interaction of beta-amyloid (Abeta) peptides with externally applied electric fields (EF) of varying strengths was investigated by means of molecular dynamics (MD) simulations. The results suggest that the EF favors the switch of Abeta-peptides from helical to beta-sheet conformation, and a mechanism is tentatively proposed. Switching off the field does not restore the original conformation.
authors.affiliation: Dipartimento di Chimica, Universita di Bologna, 40126 Bologna, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Toschi
authors.forename: Francesca
authors.initials: F
authors.lastname: Lugli
authors.forename: Fabio
authors.initials: F
authors.lastname: Biscarini
authors.forename: Francesco
authors.initials: F
authors.lastname: Zerbetto
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry*; D003198:Computer Simulation; D008968:Molecular Conformation; D010446:Peptide Fragments / Q000737:chemistry*; D017433:Protein Structure, Secondary; D013995:Time
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40)