title: Mitochondrial DNA haplogroups J and K are not protective for Parkinson's disease in the Australian community.
abstract: MtDNA haplogroups J and K have been associated with a decreased risk of developing Parkinson's disease (PD). To confirm this finding, we compared the distribution of mtDNA haplogroups J and K in a large sample of Australian patients with PD (n = 890) to population-based controls (n = 3,491). We assigned subjects to haplogroups J or K using standard PCR/RFLP techniques. Of the 890 subjects with PD, 10.6% were haplogroup J (95% CI 8.6-12.8, n = 94) and 7.1% were haplogroup K (95% CI 5.5-8.9, n = 63). In our controls, 10.2% belonged to haplogroup J (95% CI 9.2-11.2, n = 356), and 7.8% were in haplogroup K (95% CI 6.9-8.7, n = 272). There was no significant difference in the prevalence of mtDNA haplogroup J or K in PD patients compared to population-based controls. Our findings indicate that mtDNA haplogroups J and K are not associated with a lower risk of PD.
authors.affiliation: Department of Neurology and Neurogenetics, Kolling Institute, Royal North Shore Hospital and University of Sydney, Sydney, Australia.
authors.forename: Prachi
authors.initials: P
authors.lastname: Mehta
authors.forename: George D
authors.initials: GD
authors.lastname: Mellick
authors.forename: Dominic B
authors.initials: DB
authors.lastname: Rowe
authors.forename: Glenda M
authors.initials: GM
authors.lastname: Halliday
authors.forename: Michael M
authors.initials: MM
authors.lastname: Jones
authors.forename: Neil
authors.initials: N
authors.lastname: Manwaring
authors.forename: Himesha
authors.initials: H
authors.lastname: Vandebona
authors.forename: Peter A
authors.initials: PA
authors.lastname: Silburn
authors.forename: Jie Jin
authors.initials: JJ
authors.lastname: Wang
authors.forename: Paul
authors.initials: P
authors.lastname: Mitchell
authors.forename: Carolyn M
authors.initials: CM
authors.lastname: Sue
mesh_terms: D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D001315:Australia / Q000453:epidemiology; D016022:Case-Control Studies; D004272:DNA, Mitochondrial / Q000145:classification / Q000235:genetics*; D005060:Europe / Q000208:ethnology; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D044465:White People / Q000235:genetics
chemical_list: D004272:DNA, Mitochondrial