title: Cutaneous umbilical endometriosis.
abstract: A 35-year-old woman presented with a four-month history of a tender umbilical nodule that bleeds during her menstrual period. Physical examination showed a hyperpigmented umbilical nodule. A biopsy specimen showed fibrotic dermis with increased numbers of blood vessels and scattered glandular structures with areas of hemosiderin deposition consistent with a diagnosis of endometriosis. Cutaneous umbilical endometriosis is rare, with an estimated incidence of 0.5 to 1.0 percent. Although anti-gonadotropin medications, such as danazol, have been used for symptomatic control, but surgical excision is the treatment of choice owing to the possibility of malignant degeneration of cutaneous endometriosis.
authors.affiliation: Department of Dermatology, New York University, USA.
authors.forename: Arnold
authors.initials: A
authors.lastname: Lee
authors.forename: Hien T
authors.initials: HT
authors.lastname: Tran
authors.forename: Ruth F
authors.initials: RF
authors.lastname: Walters
authors.forename: Herman
authors.initials: H
authors.lastname: Yee
authors.forename: Karla
authors.initials: K
authors.lastname: Rosenman
authors.forename: Miguel R
authors.initials: MR
authors.lastname: Sanchez
mesh_terms: D000328:Adult; D001706:Biopsy; D020405:Dermis / Q000098:blood supply / Q000737:chemistry / Q000473:pathology; D004715:Endometriosis / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D005260:Female; D005355:Fibrosis; D006485:Hemosiderin / Q000032:analysis; D006801:Humans; D017495:Hyperpigmentation / Q000209:etiology; D012871:Skin Diseases / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D014472:Umbilicus / Q000473:pathology*
chemical_list: D006485:Hemosiderin