Mouse models in liver cancer research: a review of current literature.
Primary liver cancer remains one of the most lethal malignancies worldwide. Due to differences in prevalence of etiological factors the incidence of primary liver cancer varies among the world, with a peak in East-Asia. As this disease is still lethal in most of the cases, research has to be done to improve our understanding of the disease, offering insights for possible treatment options. For this purpose, animal models are widely used, especially mouse models. In this review, we describe the different types of mouse models used in liver cancer research, with emphasis on genetically engineered mice used in this field. We focus on hepatocellular carcinoma (HCC), as this is by far the most common type of primary liver cancer, accounting for 70%-85% of cases.
Leenders
Martijn W H
MW
Department of Surgery, University Medical Center Utrecht, PO box 85500, Utrecht GA 3508, The Netherlands.
Nijkamp
Maarten W
MW
Borel Rinkes
Inne H M
IH
D000818:Animals; D002273:Carcinogens; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced / Q000235:genetics / Q000821:virology; D004195:Disease Models, Animal; D005818:Genetic Engineering; D016174:Hepacivirus; D006515:Hepatitis B virus; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000235:genetics / Q000821:virology; D051379:Mice
D002273:Carcinogens