title: A global evaluation of voriconazole activity tested against recent clinical isolates of Candida spp.
abstract: Voriconazole susceptibility testing was performed on 7191 Candida spp. from 78 centers worldwide between 2004 and 2007. Voriconazole was very active in vitro (MIC(50)/MIC(90), 0.008/0.25 microg/mL; 98% susceptible). In comparison to 5866 Candida spp. isolates collected during global surveillance from 1997 to 2001, there were no changes in voriconazole mean MIC or MIC distribution.
authors.affiliation: Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA. daniel-diekema@uiowa.edu
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Diekema
authors.forename: Shawn A
authors.initials: SA
authors.lastname: Messer
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Hollis
authors.forename: Linda
authors.initials: L
authors.lastname: Boyken
authors.forename: Shailesh
authors.initials: S
authors.lastname: Tendolkar
authors.forename: Jennifer
authors.initials: J
authors.lastname: Kroeger
authors.forename: Ronald N
authors.initials: RN
authors.lastname: Jones
authors.forename: Michael A
authors.initials: MA
authors.lastname: Pfaller
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects* / Q000302:isolation & purification; D002177:Candidiasis / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology*; D025141:Drug Resistance, Fungal; D014943:Global Health; D006801:Humans; D008826:Microbial Sensitivity Tests; D011159:Population Surveillance; D011743:Pyrimidines / Q000494:pharmacology*; D014230:Triazoles / Q000494:pharmacology*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole