title: Virilization persists in a woman with an androgen-secreting granulosa cell tumor.
abstract: OBJECTIVE
  To report a case of a woman who presented with amenorrhea and masculinization secondary to an androgen-secreting granulosa cell (GC) tumor, with refractory masculinization.
  
  
  METHODS
  Case report.
  
  
  METHODS
  University medical center.
  
  
  METHODS
  A 45-year-old woman with abrupt onset of virilization with high serum androgen levels.
  
  
  METHODS
  Exploratory laparotomy with full staging.
  
  
  METHODS
  Surgical findings and histopathologic observations are included in this report.
  
  
  RESULTS
  Pathologic examination revealed an inhibin stain positive GC tumor of the adult type. Virilization has persisted for 8 years after surgery.
  
  
  CONCLUSIONS
  Adult-type GC tumor is an extremely rare cause of virilization. Masculinization features may persist in the absence of high androgen levels.
authors.affiliation: Departments of Obstetrics & Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9032, USA.
authors.forename: Satin S
authors.initials: SS
authors.lastname: Patel
authors.forename: Kelley S
authors.initials: KS
authors.lastname: Carrick
authors.forename: Bruce R
authors.initials: BR
authors.lastname: Carr
mesh_terms: D000568:Amenorrhea / Q000209:etiology / Q000378:metabolism; D000728:Androgens / Q000097:blood*; D001062:Appendectomy; D005260:Female; D006106:Granulosa Cell Tumor / Q000150:complications* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D006801:Humans; D007044:Hysterectomy; D007265:Inhibins / Q000378:metabolism; D008197:Lymph Node Excision; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D010052:Ovariectomy; D016896:Treatment Outcome; D014770:Virilism / Q000209:etiology* / Q000378:metabolism
chemical_list: D000728:Androgens; D007265:Inhibins