[Hemorrhagic stroke: molecular mechanisms of pathogenesis and perspective therapeutic targets].
Key mechanisms of an induction and development of a hemorrhage insult are considered in the review. Action of the whole hemoglobin, products of blood destruction, and also the effects caused by nitric oxide are analyzed. The special attention is given to processes of a blood-brain barrier disruption, a water homeostasis and to development of a brain edema. The role of serum proteins and thrombin is considered. Data about involving of the heat shock proteins in development of a cerebral insult are resulted in a final part of the review.
Khama-Murad
A Kh
AKh
Pavlinova
L I
LI
Mokrushin
A A
AA
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000378:metabolism; D001929:Brain Edema / Q000209:etiology / Q000378:metabolism / Q000628:therapy; D006801:Humans; D020300:Intracranial Hemorrhages / Q000150:complications / Q000378:metabolism / Q000628:therapy; D020521:Stroke / Q000209:etiology / Q000378:metabolism / Q000628:therapy
D001798:Blood Proteins