title: Streptomyces morphogenetics: dissecting differentiation in a filamentous bacterium.
abstract: During the life cycle of the filamentous bacteria Streptomyces, morphological differentiation is closely integrated with fundamental growth and cell-cycle processes, as well as with truly complex multicellular behaviour that involves hormone-like extracellular signalling and coordination with an extraordinarily diverse secondary metabolism. Not only are the bacterial cytoskeleton and the machineries for cell-wall assembly, cell division and chromosome segregation reorganized during sporulation, but the developmental programme of these fascinating organisms also has many unusual elements, including the formation of a sporulating aerial mycelium and the production of a surfactant peptide and a hydrophobic sheath that allow cells to escape from the surface tension of the growth medium.
authors.affiliation: Department of Cell and Organism Biology, Lund University, Lund, Sweden. mark.buttner@bbsrc.ac.uk
authors.forename: Klas
authors.initials: K
authors.lastname: Flärdh
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Buttner
mesh_terms: D009024:Morphogenesis; D013302:Streptomyces / Q000166:cytology* / Q000502:physiology*