title: Pseudomonas aeruginosa PAO1 pyocin production affects population dynamics within mixed-culture biofilms.
abstract: Transcriptomic and phenotypic studies showed that pyocins are produced in Pseudomonas aeruginosa PAO1 aerobic and anaerobic biofilms. Pyocin activity was found to be high in slow-growing anaerobic biofilms but transient in aerobic biofilms. Biofilm coculture of strain PAO1 and a pyocin-sensitive isolate showed that pyocin production had a significant impact on bacterial population dynamics, particularly under anaerobic conditions.
authors.affiliation: Queen Mary University of London, Barts & The London School of Medicine and Dentistry, Centre for Infectious Disease, Institute of Cell and Molecular Science, 4 Newark Street, London E1 2AT, United Kingdom. R.D.Waite@qmul.ac.uk
authors.forename: Richard D
authors.initials: RD
authors.lastname: Waite
authors.forename: Michael A
authors.initials: MA
authors.lastname: Curtis
mesh_terms: D000332:Aerobiosis; D000693:Anaerobiosis; D018441:Biofilms / Q000254:growth & development; D018920:Coculture Techniques; D020869:Gene Expression Profiling; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology; D011550:Pseudomonas aeruginosa / Q000378:metabolism* / Q000502:physiology; D011709:Pyocins / Q000096:biosynthesis*; D014158:Transcription, Genetic
chemical_list: D011709:Pyocins