[Simulation of the disease caused by Hantaan virus in white mice by a complex of virological, biochemical, and hematological parameters].
The essence of studies was that the disease is simulated in 12-day albino mice subcutaneously infected with Hantaan virus, strain 76-118 in a dose of 10 LD50. As an efficiency index, the study of drugs uses major (death protection coefficient, mean animal lifetime) and auxiliary (virological: pathogen accumulation in the brain tissues of deceased animals) parameters, biochemical (the levels of creatinine, urea, alanine aminotransferase, aspartate aminotransferase, malonic dialdehyde), hematological (count of leukocytes, leukogram) ones; as well as interferon status (the levels of circulatory interferon, leukocytic production of alpha- and gamma-interferons). The procedure for simulating the disease caused by Hantaan virus on an experimental animal is used to choose effective drugs against the pathogen of hemorrhagic nephrosonephritis.
Koval'chuk
A V
AV
Loginova
S Ia
SIa
Borisevich
S V
SV
Kopylova
N K
NK
Pashchenko
Iu I
IuI
Khamitov
R A
RA
Maksimov
V A
VA
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000831:Animals, Newborn; D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology; D001219:Aspartate Aminotransferases / Q000097:blood; D001921:Brain / Q000821:virology; D003404:Creatinine / Q000097:blood; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D018063:Hantaan virus / Q000187:drug effects; D006480:Hemorrhagic Fever with Renal Syndrome / Q000097:blood / Q000276:immunology / Q000821:virology; D007372:Interferons / Q000096:biosynthesis; D007928:Lethal Dose 50; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D008314:Malonates / Q000097:blood; D051379:Mice; D011817:Rabbits; D051381:Rats; D014508:Urea / Q000097:blood
D000998:Antiviral Agents; D008314:Malonates; D014508:Urea; D007372:Interferons; C030290:malonic acid; D003404:Creatinine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase