title: The FUSE binding proteins FBP1 and FBP3 are potential c-myc regulators in renal, but not in prostate and bladder cancer.
abstract: BACKGROUND
  The three far-upstream element (FUSE) binding proteins (FBP1, FBP2, and FBP3) belong to an ancient family of single-stranded DNA binding proteins which are required for proper regulation of the c-myc proto-oncogene. Whereas it is known that c-myc alterations play a completely different role in various carcinomas of the urogenital tract, the relevance of FBPs is unclear.
  
  
  METHODS
  FBP1, FBP3 and c-myc expression was studied in 105 renal cell, 95 prostate and 112 urinary bladder carcinomas by immunohistochemistry using tissue microarrays.
  
  
  RESULTS
  High rates of FBP1 and FBP3 expression were observed in all cancer types. There was a concomitant up-regulation of FBP1 and FBP3 in renal cell and prostate carcinomas (p < 0.001 both). C-myc expression was detectable in 21% of prostate, 30% of renal and 34% of urothelial carcinomas. Interestingly, strong FBP1 and FBP3 expression was associated with c-myc up-regulation in clear cell renal cell carcinomas (p < 0.001 and 0.09 resp.), but not in bladder or prostate cancer.
  
  
  CONCLUSIONS
  The correlation between FBP1/FBP3, c-myc and high proliferation rate in renal cell carcinoma provides strong in vivo support for the suggested role of FBP1 and FBP3 as activators of c-myc. The frequent up-regulation of FBP1 and FBP3 in urothelial and prostate carcinoma suggests that FBPs also have an important function in gene regulation of these tumors.
authors.affiliation: Department of Pathology, Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland. achim.weber@usz.ch
authors.forename: Achim
authors.initials: A
authors.lastname: Weber
authors.forename: Ilka
authors.initials: I
authors.lastname: Kristiansen
authors.forename: Manfred
authors.initials: M
authors.lastname: Johannsen
authors.forename: Beibei
authors.initials: B
authors.lastname: Oelrich
authors.forename: Katharina
authors.initials: K
authors.lastname: Scholmann
authors.forename: Sven
authors.initials: S
authors.lastname: Gunia
authors.forename: Matthias
authors.initials: M
authors.lastname: May
authors.forename: Hellmuth-Alexander
authors.initials: HA
authors.lastname: Meyer
authors.forename: Silvia
authors.initials: S
authors.lastname: Behnke
authors.forename: Holger
authors.initials: H
authors.lastname: Moch
authors.forename: Glen
authors.initials: G
authors.lastname: Kristiansen
mesh_terms: D016009:Chi-Square Distribution; D004265:DNA Helicases / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology; D000090063:Proto-Oncogene Mas; D016601:RNA-Binding Proteins; D018709:Statistics, Nonparametric; D046888:Tissue Array Analysis; D014157:Transcription Factors / Q000378:metabolism*; D001749:Urinary Bladder Neoplasms / Q000378:metabolism / Q000473:pathology; D014565:Urogenital Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D004268:DNA-Binding Proteins; C492258:FUBP1 protein, human; C492259:FUBP3 protein, human; C000715470:MAS1 protein, human; C116115:MYCBP protein, human; D000090063:Proto-Oncogene Mas; D016601:RNA-Binding Proteins; D014157:Transcription Factors; D004265:DNA Helicases