title: Glucose-6-phosphate dehydrogenase deficiency and sickle cell disease in Burkina Faso.
abstract: Where malaria is endemic, there is an unexpected association between haemoglobinopathies and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency. Their coexistence in a patient with sickle cell disease (SCD) can lead to hemolytic anemia, hemoglobinuria, sepsis, renal failure and vaso-occlusive attacks (VOA). The aim of this research was to determine the impact of G-6-PD deficiency in SCD patients. That is why, we screened haemoglobinopathies and G-6-PD deficiency in 7 villages and at 10 primary schools in Kadiogo Province, Burkina Faso. Hemoglobin electrophoresis was performed on blood from 18,383 people. From these results, we chose 342 subjects for a hemogram and the measure of the G-6-PD activity. The results were analyzed with Epilnfo-6 and Spss-10. Statistical significance was set at p < 0.05. We found a prevalence of 28.9% of Sickle Cell Trait (SCT), 1.3% of Major Sickle Cell Syndromes (MSCS), 12.3% of G-6-PD deficiency among women and 20.5% among men. We did not detect a statistically significant difference for counts of erythrocytes (p = 0.773), leucocytes (p = 0.227) and reticulocytes (0.292); hemoglobin levels (p = 0.998); annual vasoocclusive attacks (p = 0.869) between persons with SCD having a G-6-PD deficiency and those with normal G-6-PD activity. According to this study, G-6-PD deficiency does not seem to increase the severity of SCD. However, these patients should know their G-6-PD genotype in order to avoid consuming oxidative drugs that might provoke oxidative stress.
authors.affiliation: Centre Medical Saint Camille, 01 BP 364 Ouagadougou 01, Burkina Faso, Italy.
authors.forename: Jacques
authors.initials: J
authors.lastname: Simpore
authors.forename: Denise
authors.initials: D
authors.lastname: Ilboudo
authors.forename: Karou
authors.initials: K
authors.lastname: Damintoti
authors.forename: Luc
authors.initials: L
authors.lastname: Sawadogo
authors.forename: Esposito
authors.initials: E
authors.lastname: Maria
authors.forename: Scott
authors.initials: S
authors.lastname: Binet
authors.forename: Henri
authors.initials: H
authors.lastname: Nitiema
authors.forename: Paul
authors.initials: P
authors.lastname: Ouedraogo
authors.forename: Salvatore
authors.initials: S
authors.lastname: Pignatelli
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Nikiema
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D000755:Anemia, Sickle Cell / Q000201:enzymology* / Q000453:epidemiology* / Q000235:genetics; D002050:Burkina Faso / Q000453:epidemiology; D002648:Child; D005260:Female; D005838:Genotype; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D008297:Male
chemical_list: D005954:Glucosephosphate Dehydrogenase