Bullous pemphigoid followed by pustular psoriasis showing Th1, Th2, Treg and Th17 immunological changes.
Psoriasis vulgaris is occasionally accompanied by autoimmune bullous diseases, but the opposite is very rare. We document here the first reported case of generalized pustular psoriasis that appeared during steroid therapy for bullous pemphigoid. The serum cytokine levels and the results of an immunohistochemical study over the disease course suggest that the immunological state was consistent with a shift from Th2-dominance to Th1-dominance. IL-17-producing cells appeared in the skin lesions when each disease was most exacerbated and disappeared after remission. Thus, the present case demonstrated a dynamic immunological state in which the appearances of Th1 and Th2 as well as Th17 varied during the course of the disease.
Yasukawa
Shinsuke
S
Department of Dermatology, Graduate School of Medical Sciences, Kyusyu University, Fukuoka, Japan.
Dainichi
Teruki
T
Kokuba
Hisashi
H
Moroi
Yoichi
Y
Urabe
Kazunori
K
Hashimoto
Takashi
T
Furue
Masutaka
M
D000328:Adult; D001623:Betamethasone / Q000627:therapeutic use; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007150:Immunohistochemistry; D007371:Interferon-gamma / Q000097:blood; D008297:Male; D010391:Pemphigoid, Bullous / Q000188:drug therapy / Q000276:immunology*; D011565:Psoriasis / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D005938:Glucocorticoids; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma; D001623:Betamethasone