Stimulating conversations between HP1a and histone demethylase dKDM4A.
An interaction between Drosophila HP1a and H3K36 histone demethylase dKDM4A reported in this issue of Molecular Cell (Lin et al., 2008) offers an explanation for association of HP1a with active genes, reinforcing the notion of dynamic interplay among epigenetic marks on histone tails during transcription.
Wallrath
Lori L
LL
Department of Biochemistry, University of Iowa, Iowa City, IA 52242, USA.
Elgin
Sarah C R
SC
D000818:Animals; D000090266:Chromobox Protein Homolog 5; D002868:Chromosomal Proteins, Non-Histone / Q000737:chemistry / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000166:cytology / Q000201:enzymology*; D006657:Histones / Q000378:metabolism; D008239:Lysine / Q000378:metabolism; D008745:Methylation; D008954:Models, Biological; D010089:Oxidoreductases, N-Demethylating / Q000737:chemistry / Q000378:metabolism*; D017434:Protein Structure, Tertiary
D002868:Chromosomal Proteins, Non-Histone; D006657:Histones; D000090266:Chromobox Protein Homolog 5; D010089:Oxidoreductases, N-Demethylating; D008239:Lysine