title: [Evaluation of the carcinogenic activity of phenol-free coal-tar creolin].
abstract: When orally administered to rats and mice, phenol-free coal-tar creolin containing 0.018+/-0.002 g/kg of benz(a)pyrene showed no carcinogenic activity. The discrepancy of the biological activity and content of carcinogen in the combined mixture, the role of their components in carcinogenesis, the value of control experiments, and historic control test, and the implication of these rapid tests in the evaluation of their carcinogenicity is shown.
authors.forename: L N
authors.initials: LN
authors.lastname: Pylev
authors.forename: L A
authors.initials: LA
authors.lastname: Vasil'eva
authors.forename: S S
authors.initials: SS
authors.lastname: Levinskiĭ
authors.forename: I A
authors.initials: IA
authors.lastname: Khitrovo
authors.forename: S A
authors.initials: SA
authors.lastname: Khrustalev
authors.forename: G M
authors.initials: GM
authors.lastname: Trukhina
mesh_terms: D000818:Animals; D015197:Carcinogenicity Tests; D003033:Coal Tar / Q000633:toxicity*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: C017152:creolin; D003033:Coal Tar