[The effects of modulation of cardiac metabolism and antioxidant state on myocardial ischemia-reperfusion injury].
The effects of mexicor (ethylmethylhydroxypyridine succinate) at doses of 50 and 100 mg/kg on myocardial infarct size, serum levels of myocardial markers, and severity of ischemia- and reperfusion-induced arrhythmias were studied in the rat model of myocardial ischemia-reperfusion injury. It was shown that pre-ischemic intravenous infusion of mexicor at a dose of 50 mg/kg resulted in significant reduction of myocardial infarct size and troponin I level. When the dose of mexicor was increased up to 100 mg/kg the infarct-limiting effect was reversed. Both doses of mexicor tested in this study failed to protect the heart from ischemic tachyarrhythmias but decreased the occurrence of persistent reperfusion-induced ventricular fibrillation.
Syrenskiĭ
A V
AV
Galagudza
M M
MM
Egorova
E I
EI
Morozova
L Iu
LIu
Polumiskov
V Iu
VIu
Tsyrlin
V A
VA
D000818:Animals; D015415:Biomarkers / Q000097:blood; D004305:Dose-Response Relationship, Drug; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000097:blood* / Q000150:complications / Q000188:drug therapy*; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D019210:Troponin I / Q000097:blood*; D014693:Ventricular Fibrillation / Q000097:blood* / Q000188:drug therapy* / Q000209:etiology
D015415:Biomarkers; D011725:Pyridines; D019210:Troponin I; C517040:ethylmethylhydroxypyridine succinate