ER stress and lipogenesis: a slippery slope toward hepatic steatosis.
Endoplasmic reticulum (ER) stress and activation of the unfolded protein response have been linked to many human disorders, including obesity, type 2 diabetes, and cancer. In this issue of Developmental Cell,Rutkowski et al. (2008) show that unresolved ER stress contributes to metabolic dysfunction and hepatic steatosis.
Basseri
Sana
S
Department of Medicine, McMaster University, St. Joseph's Healthcare and the Henderson Research Centre, Hamilton, ON, Canada.
Austin
Richard C
RC
D000818:Animals; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism; D005234:Fatty Liver / Q000175:diagnosis* / Q000473:pathology*; D006801:Humans; D008055:Lipids / Q000737:chemistry; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological; D010100:Oxygen / Q000378:metabolism; D011489:Protein Denaturation; D017510:Protein Folding; D014280:Triglycerides / Q000378:metabolism; D015854:Up-Regulation
D005227:Fatty Acids; D008055:Lipids; D014280:Triglycerides; D010100:Oxygen