title: Dietary inositol hexakisphosphate, but not myo-inositol, clearly improves hypercholesterolemia in rats fed casein-type amino acid mixtures and 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane.
abstract: We have previously shown that dietary inositol hexakisphosphate (IP6) and myo-inositol prevent fatty liver in rats fed a casein-based diet containing 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane (DDT). This study was performed to examine the comparative effects of dietary equimolar amounts of sodium IP6 (1.02%) and myo-inositol (0.2%) on the development of DDT-induced fatty liver and hypercholesterolemia in rats fed 20% casein-type amino acid mixtures designed to exclude a possible myo-inositol contaminant in casein. Thirty-six male Wistar rats were divided into 6 groups of 6 rats each for: a control group, myo-inositol-supplemented group, IP6-supplemented group, DDT-treated group, DDT + myo-inositol-supplemented group, and a DDT + IP6-supplemented group. Dietary IP6 clearly suppressed the rises in serum concentrations of cholesterol and phospholipids because of DDT feeding, but myo-inositol had no significant influence on such elevations. Dietary IP6, but not myo-inositol, caused significant body weight gain with or without DDT intake. Supplemental IP6 and myo-inositol significantly increased hepatic-free myo-inositol regardless of DDT intake and prevented fatty liver in rats fed DDT. In conclusion, dietary IP6 and myo-inositol exert similar effects on DDT-induced fatty liver and myo-inositol status but distinct effects on DDT-induced hypercholesterolemia and growth rate in rats fed casein-type amino acid mixtures.
authors.affiliation: Department of Human Life Sciences Education, Graduate School of Education, Hiroshima University, Higashi-Hiroshima 739-8524, Japan. yokazaki@fujijoshi.ac.jp
authors.forename: Yukako
authors.initials: Y
authors.lastname: Okazaki
authors.forename: Tetsuyuki
authors.initials: T
authors.lastname: Katayama
mesh_terms: D000818:Animals; D002364:Caseins / Q000008:administration & dosage*; D002784:Cholesterol / Q000097:blood; D003634:DDT / Q000633:toxicity; D005234:Fatty Liver / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D006937:Hypercholesterolemia / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D007294:Inositol / Q000494:pharmacology*; D008297:Male; D010743:Phospholipids / Q000097:blood; D010833:Phytic Acid / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D002364:Caseins; D010743:Phospholipids; D007294:Inositol; D010833:Phytic Acid; D002784:Cholesterol; D003634:DDT