[Evaluation of Yunnan Baiyao capsules for reducing postoperative swelling after orthognathic surgery].
OBJECTIVE
To evaluate the effects of Yunnan Baiyao capsules on facial swelling and anti-inflammatory response after orthognathic surgery.


METHODS
87 patients scheduled for Le Fort I osteotomy and bilateral sagittal split ramus osteotomy (BSSRO) and genioplasty were randomly divided into 2 groups: experiment roup (n = 43) given with Yunnan Baiyao capsules orally 4 days before operation once daily and then via nasal feeding tube after operation once a day for 5 days, and placebo group given with placebo capsules. Antibiotic was routinely given to both groups. Serum levels of C-reactive protein (CRP), interleukin 6 (IL-6), and IL-1 were quantified on postoperative days 1, 2, 3, and 5. Degrees of facial swelling were evaluated on postoperative days 3, 5, and 7.


RESULTS
Peak CRP and cytokines levels were reached on the first postoperative day in both groups, and the the variables decreased. The serum concentrations of CRP and IL-6 in the Yunan Baiyao group were lower than those in the control group. The CRP levels on the postoperative day 2, 3 and 5 of the experiment group were all significantly lower than those of the placebo group, and the IL-6 level on the second postoperative day of the experiment group was significantly lower than that of the placebo group.


CONCLUSIONS
Perioperative administration of Yunnan Baiyao capsules can reduce the magnitude of inflammatory response and facial swelling after orthognathic surgery. Yunnan Baiyao capsule has efficacy of anti-inflammatory response.
Tang
Zheng-long
ZL
Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Peking University, Beijing 100081, China. Email: kqwx@vip.sina.com.
Wang
Xing
X
Yi
Biao
B
Li
Zi-Li
ZL
Liang
Cheng
C
Wang
Xiao-xia
XX
D000293:Adolescent; D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism; D002214:Capsules; D004311:Double-Blind Method; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004487:Edema / Q000188:drug therapy / Q000209:etiology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000188:drug therapy*; D007375:Interleukin-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D019647:Oral Surgical Procedures / Q000009:adverse effects; D008517:Phytotherapy; D010919:Placebos; D011183:Postoperative Complications / Q000097:blood / Q000188:drug therapy*; D011446:Prospective Studies
D002214:Capsules; D004365:Drugs, Chinese Herbal; D007375:Interleukin-1; D015850:Interleukin-6; D010919:Placebos; D002097:C-Reactive Protein