title: Serum levels of pigment epithelium-derived factor (PEDF) are an independent determinant of insulin resistance in patients with essential hypertension.
abstract: We have previously found that serum level of pigment epithelium-derived factor (PEDF) is increased in proportion to the accumulation of the number of components of metabolic syndrome in general population. However, the link between PEDF and insulin resistance in hypertensive patients remains unclear. We investigated here whether serum PEDF level was associated with insulin resistance in hypertensive patients. Ninety-seven consecutive outpatients with essential hypertension underwent a complete history and physical examination, determination of blood chemistries, including serum PEDF. In multiple regression analyses, BMI, age (inversely) and PEDF were independently correlated with homeostasis model assessment of insulin resistance (HOMA-IR). When age- and sex-adjusted PEDF levels were stratified by HOMA-IR tertiles, a linear and significant trend was observed. These results demonstrated that serum level of PEDF was an independent determinant of HOMA-IR in patients with essential hypertension. PEDF may play a role in insulin resistance in hypertensive patients.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Nakamura
authors.forename: Sho-ichi
authors.initials: S
authors.lastname: Yamagishi
authors.forename: Hisashi
authors.initials: H
authors.lastname: Adachi
authors.forename: Takanori
authors.initials: T
authors.lastname: Matsui
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Kurita
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Imaizumi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000175:diagnosis; D005136:Eye Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications*; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D009414:Nerve Growth Factors / Q000097:blood*; D015843:Serpins / Q000097:blood*; D000099174:Pigment Epithelium-Derived Factor
chemical_list: D015415:Biomarkers; D005136:Eye Proteins; D009414:Nerve Growth Factors; D015843:Serpins; D000099174:Pigment Epithelium-Derived Factor