[Co-adaptation of enzymatic systems of cells and blood supply in smooth muscle tumors of the corpus uteri].
We investigated co-adaptation of enzymatic systems of cells using data on activity of NAD(Ph)-dependent enzymes and AgNOR proteins of vascular endothelium vis-a-vis angiogenesis in benign and malignant smooth muscle tumors of the corpus uteri. Overall metabolic activity (NAD-H2 diaphorase) was found to directly correlate with angiogenesis and endothelial vessel proliferation (r = 0.76 and 0.84, respectively). SDH-regulated oxidation in the main metabolic succession of a tricarbonic acid cycle depended on blood supply and endothelial vessel proliferation (r = 0.84 and 0.92, respectively; p = 0.04). A similar relationship was shown for anaerobic glycolysis of SDH (LDH content), on the one hand, and blood supply and endothelial vessel proliferation(r = 0.57 and 0.70, respectively; p = 0.02), on the other. Hence, metabolic profile varied in unaltered myometrium and tumor with variable cellular density and peculiar extracellular matrix. The highest levels of metabolic activity with NAD(Ph)-dependent enzyme co-adaptation was observed in sarcomas which were also characterized by the highest vascular density for endothelial proliferation.
Lazaarev
A F
AF
Avbalian
A M
AM
Bobrov
I P
IP
Klimachev
V V
VV
Mischenko
E V
EV
D000328:Adult; D034961:Antigens, Nuclear / Q000378:metabolism*; D005260:Female; D006019:Glycolysis; D006801:Humans; D008875:Middle Aged; D009249:NADP / Q000378:metabolism*; D009389:Neovascularization, Pathologic / Q000201:enzymology / Q000378:metabolism*; D012509:Sarcoma / Q000098:blood supply / Q000378:metabolism; D013385:Succinate Dehydrogenase / Q000378:metabolism; D014594:Uterine Neoplasms / Q000098:blood supply* / Q000201:enzymology / Q000378:metabolism*
D034961:Antigens, Nuclear; C051963:nucleolar organizer region associated proteins; D009249:NADP; D013385:Succinate Dehydrogenase