title: Mechanical degradation of drag reducing polymers in suspensions of blood cells and rigid particles.
abstract: Natural and synthetic soluble drag reducing polymers (DRP) have been shown to produce beneficial effects on blood circulation in various animal models and may represent a novel bioengineering way to treat cardiovascular disorders. These polymers are known to degrade when subjected to high shear stresses which could be a part of the process of their elimination from the vascular system. However, the relative rate of their degradation was not known especially in the presence of blood cells or particles. The hydrodynamic tests in this study demonstrated that DRP mechanical degradation was significantly increased by the presence of red blood cells (RBC) and even more so by the presence of rigid particles of similar size. Degradation rates increased with an increase in RBC or particle concentration. The natural DRP (derived from aloe) was shown to be much more resistant to flow-induced degradation than polyethylene oxide in the presence or absence of RBC.
authors.affiliation: McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Joie N
authors.initials: JN
authors.lastname: Marhefka
authors.forename: Sachin S
authors.initials: SS
authors.lastname: Velankar
authors.forename: Toby M
authors.initials: TM
authors.lastname: Chapman
authors.forename: Marina V
authors.initials: MV
authors.lastname: Kameneva
mesh_terms: D000504:Aloe; D000818:Animals; D001809:Blood Viscosity; D002417:Cattle; D004355:Drug Stability; D004912:Erythrocytes / Q000502:physiology*; D005990:Glycerol; D018056:Hemorheology; D008863:Microspheres; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers
chemical_list: D011108:Polymers; D011092:Polyethylene Glycols; D005990:Glycerol