[Influence of mutations of proteinase-activated receptors F2R/PAR1 and F2RL1/PAR2 on inflammatory bowel disease].
OBJECTIVE
Inflammatory bowel disease (IBD) is a polygenic complex trait. The expression and presence in biopsiae from IBD patients points to a putative role of these genes in genetic susceptibility to IBD. This is the first association study on these genes in relation with IBD.


METHODS
Two polymorphisms were analyzed within F2R/PAR1 and another one mapping to F2RL1/PAR2 in 778 healthy controls and 943 IBD cases (Crohn's disease and ulcerative colitis patients from 2 cohorts from Madrid and Granada).


RESULTS
No significant differences in the distribution of the PARs' polymorphisms were found.


CONCLUSIONS
There is no evidence of association of the analyzed polymorphisms with IBD risk.
Martín
M Carmen
MC
Servicio de Inmunología Clínica, Hospital Clínico San Carlos, Madrid, España. cmartal@terra.es
Oliver
Javier
J
Mendoza
Juan Luis
JL
Fernández-Arquero
Miguel
M
Martín
Javier
J
Urcelay
Elena
E
D015331:Cohort Studies; D003093:Colitis, Ulcerative / Q000453:epidemiology / Q000235:genetics*; D003424:Crohn Disease / Q000453:epidemiology / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007438:Introns / Q000235:genetics; D015810:Linkage Disequilibrium; D016254:Mutagenesis, Insertional; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D044463:Receptor, PAR-1 / Q000235:genetics*; D018179:Receptors, Thrombin / Q000235:genetics*; D012306:Risk; D013030:Spain / Q000453:epidemiology
D044463:Receptor, PAR-1; D018179:Receptors, Thrombin; C105295:protease-activated receptor 3