Palladium-catalyzed Suzuki-Miyaura coupling of pyridyl-2-boronic esters with aryl halides using highly active and air-stable phosphine chloride and oxide ligands.
The palladium-catalyzed Suzuki-Miyaura coupling of pyridyl-2-boronic esters provided an efficient approach to useful biaryl building blocks containing a 2-pyridyl moiety. The convenient reaction protocol demonstrates its potentially wide applications in medicinal chemistry.
Yang
David X
DX
Department of Medicinal Chemistry, Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065-0900, USA.
Colletti
Steven L
SL
Wu
Kevin
K
Song
Maoying
M
Li
George Y
GY
Shen
Hong C
HC
D000388:Air; D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D004952:Esters / Q000737:chemistry*; D006219:Halogens / Q000737:chemistry*; D008024:Ligands; D010087:Oxides / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*
D001897:Boronic Acids; D004952:Esters; D006219:Halogens; D008024:Ligands; D010087:Oxides; D010720:Phosphines; D010165:Palladium; C044646:phosphine