title: [Systemic biologic study on traditional Chinese medicine--a short-lived fad or a long-term policy?].
abstract: The research of traditional Chinese medicine (TCM) has failed to achieve major breakthrough, especially on some important and fundamental medical problems and concepts. One of the reasons for such failure is that the methodology used in the TCM research follows basically the path of partitioned reductive analysis, which is unable to capture practically the characteristics of TCM scientific system, such as the holistic and dynamic nature of diseases, and the interaction among various biological components. The systemic thinking and strategy of the systematic biology and its aim at grasping integral function have provided unprecedented enlightenment for the modem TCM research. To conduct a systemic strategic reductive analysis on human body and diseases under the guidance of holistic view will be an utmost important way for developing TCM towards the future of healthcare. The modernization of TCM does not have to follow the partitioned reductive approach, which has been practiced in the development of modern science in recent centuries. Instead, it should proceed in a "top down" way of systemic research by firstly investigating and understanding the systemic information, followed by a layered excavation on local information, so as to stride over the gap between the traditional medicine and the future medicine.
authors.affiliation: Center for Chinese Medical Therapy and Systems Biology, Shanghai University of TCM, Shanghai.
authors.forename: Ming-mei
authors.initials: MM
authors.lastname: Zhou
authors.forename: Wei
authors.initials: W
authors.lastname: Jia
authors.forename: Pei-gen
authors.initials: PG
authors.lastname: Xiao
mesh_terms: D000818:Animals; D035843:Biomedical Research; D006801:Humans; D008516:Medicine, Chinese Traditional; D011640:Public Policy; D049490:Systems Biology