title: Targeted Paclitaxel by conjugation to iron oxide and gold nanoparticles.
abstract: The Fe(3)O(4) nanoparticles, tailored with maleimidyl 3-succinimidopropionate ligands, were conjugated with paclitaxel molecules that were attached with a poly(ethylene glycol) (PEG) spacer through a phosphodiester moiety at the (C-2')-OH position. The average number of paclitaxel molecules/nanoparticles was determined as 83. These nanoparticles liberated paclitaxel molecules upon exposure to phosphodiesterase.
authors.affiliation: Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan 300, ROC.
authors.forename: Jih Ru
authors.initials: JR
authors.lastname: Hwu
authors.forename: Yu Sern
authors.initials: YS
authors.lastname: Lin
authors.forename: Thainashmuthu
authors.initials: T
authors.lastname: Josephrajan
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Hsu
authors.forename: Fong-Yu
authors.initials: FY
authors.lastname: Cheng
authors.forename: Chen-Sheng
authors.initials: CS
authors.lastname: Yeh
authors.forename: Wu-Chou
authors.initials: WC
authors.lastname: Su
authors.forename: Dar-Bin
authors.initials: DB
authors.lastname: Shieh
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods; D004354:Drug Screening Assays, Antitumor; D042783:Endothelial Cells / Q000187:drug effects; D005290:Ferric Compounds / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006801:Humans; D008301:Maleimides / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D017239:Paclitaxel / Q000737:chemistry* / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000737:chemistry; D013388:Succinimides / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005290:Ferric Compounds; D008301:Maleimides; D013388:Succinimides; C000499:ferric oxide; D011092:Polyethylene Glycols; D006046:Gold; D017239:Paclitaxel