title: Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives.
abstract: We have successfully obtained 1,2,4-oxadiazol-5-one bioisoteres of Am580 or Tazarotene-like retinoids. In particular compound 4 displays an EC(50) of 26nM on RAR-beta.
authors.affiliation: INSERM U761 Biostructures and Drug Discovery, 3 rue du Professeur Laguesse, Lille F-59006, France. julie.charton@univ-lille2.fr
authors.forename: Julie
authors.initials: J
authors.lastname: Charton
authors.forename: Rebecca
authors.initials: R
authors.lastname: Deprez-Poulain
authors.forename: Nathalie
authors.initials: N
authors.lastname: Hennuyer
authors.forename: Anne
authors.initials: A
authors.lastname: Tailleux
authors.forename: Bart
authors.initials: B
authors.lastname: Staels
authors.forename: Benoit
authors.initials: B
authors.lastname: Deprez
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry*; D010069:Oxadiazoles / Q000737:chemistry*; D018168:Receptors, Retinoic Acid / Q000187:drug effects; D012176:Retinoids / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D002264:Carboxylic Acids; D010069:Oxadiazoles; D018168:Receptors, Retinoic Acid; D012176:Retinoids; C082925:retinoic acid receptor beta