title: The aneuploidy paradox in cell growth and tumorigenesis.
abstract: Aneuploidy, an abnormal chromosome number, is a frequent characteristic of malignant cells, leading to the suggestion that aneuploidy drives tumorigenesis. In a recent issue of Science, Williams et al. identified a paradoxical relationship between aneuploidy and its linkage to tumorigenesis: chromosome gains in nontransformed cells are antiproliferative, despite frequently occurring in human tumors.
authors.affiliation: Department of Pharmacology, University of Wisconsin-Madison, Madison, WI 53706, USA. baweaver@wisc.edu
authors.forename: Beth A
authors.initials: BA
authors.lastname: Weaver
authors.forename: Don W
authors.initials: DW
authors.lastname: Cleveland
mesh_terms: D000782:Aneuploidy; D049109:Cell Proliferation; D002875:Chromosomes / Q000648:ultrastructure; D006801:Humans; D007621:Karyotyping; D008957:Models, Genetic; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics*