title: Dual-source coronary computed tomography angiography in patients with atrial fibrillation: initial experience.
abstract: BACKGROUND
  Patients with atrial fibrillation (AF) are generally excluded from coronary CT angiography (CCTA) studies because of motion artifact resulting from irregular rhythm. The 83-millisecond temporal resolution of the dual-source CT (DSCT) may be sufficient to allow CCTA in patients with AF.
  
  
  OBJECTIVE
  We examined the feasibility of DSCT in patients with AF referred for CCTA.
  
  
  METHODS
  We compared results of CCTA with DSCT in 24 consecutive patients with AF with 119 control patients in sinus rhythm. Standard relative-delay phase reconstruction (40%-80% of cardiac cycle) was used, with additional absolute delay reconstruction performed when indicated. Image quality was scored both subjectively and objectively.
  
  
  RESULTS
  Patients with AF were older (68.5 +/- 14.0 years versus 62.5 +/- 12.1 years; P = 0.03). Maximum heart rate during injection was 102.5 +/- 30.4 beats/min and 70.8 +/- 16.6 beats/min in the AF and control groups, respectively (P < 0.01). Mean (+/-SD) Agatston score was 321 +/- 366 (range, 0-1158) and 361 +/- 743 (range, 0-3948) in the AF and control groups, respectively (P = 0.8). No difference was observed in the proportion of uninterpretable segments between the 2 groups, 7 (2%) in the AF group and 12 (1%) in the control group (P = NS). Two (8%) of 24 studies in the AF group and 12 (10%) of 119 studies in the control group were nondiagnostic (P = NS). Image quality was good or excellent in 13 (54%) of 21 AF cases compared with 94 (79%) of 119 control cases (P = 0.01). Absolute delay reconstruction was needed in 9 (38%) of 24 AF cases.
  
  
  CONCLUSIONS
  These preliminary data show that interpretable CCTA data can be obtained in patients with AF using DSCT. The need for absolute delay reconstruction is common.
authors.affiliation: Departments of Imaging and Medicine, and CSMC Burns & Allen Research Institute, Cedars-Sinai Medical Center, University of California at Los Angeles, CA, USA.
authors.forename: Arik
authors.initials: A
authors.lastname: Wolak
authors.forename: Ariel
authors.initials: A
authors.lastname: Gutstein
authors.forename: Victor Y
authors.initials: VY
authors.lastname: Cheng
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Louise E
authors.initials: LE
authors.lastname: Thomson
authors.forename: John
authors.initials: J
authors.lastname: Friedman
authors.forename: Damini
authors.initials: D
authors.lastname: Dey
authors.forename: Sean W
authors.initials: SW
authors.lastname: Hayes
authors.forename: Piotr J
authors.initials: PJ
authors.lastname: Slomka
authors.forename: Guido
authors.initials: G
authors.lastname: Germano
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Berman
mesh_terms: D000368:Aged; D020517:Atrial Appendage / Q000000981:diagnostic imaging*; D001281:Atrial Fibrillation / Q000150:complications* / Q000000981:diagnostic imaging*; D017023:Coronary Angiography / Q000379:methods*; D003328:Coronary Thrombosis / Q000150:complications* / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D014057:Tomography, X-Ray Computed / Q000379:methods*