Four cases of venous thromboembolism associated with olanzapine.
OBJECTIVE
Psychiatric disorders and treatment with conventional antipsychotic medications have been associated with venous thromboembolism, but only a few data on recent antipsychotics such as olanzapine are available.


METHODS
We describe four subjects treated with olanzapine who developed venous thromboembolism, and were hospitalized at the University Hospital in Hradec Kralove during the period 2004-2006.


RESULTS
We found a combination of several clinical and laboratory risk factors in our patients.


CONCLUSIONS
A cohort study or case-control studies are needed to better elucidate the possible role of olanzapine in etiopathogenesis of venous thromboembolism.
Maly
Radovan
R
First Department of Internal Medicine, Charles University in Prague, Faculty of Medicine in Hradec Kralove and University Hospital, Hradec Kralove, Czech Republic.
Masopust
Jiri
J
Hosak
Ladislav
L
Urban
Ales
A
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001569:Benzodiazepines / Q000009:adverse effects* / Q000627:therapeutic use; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077152:Olanzapine; D012307:Risk Factors; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy; D012563:Schizophrenia, Paranoid / Q000150:complications / Q000188:drug therapy; D014463:Ultrasonography; D054556:Venous Thromboembolism / Q000139:chemically induced* / Q000000981:diagnostic imaging
D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine