title: Apolipoprotein E gene polymorphism and polycystic ovary syndrome patients in Western Anatolia, Turkey.
abstract: OBJECTIVE
  Dyslipidemia, cardiovascular disease and hypertension are more frequently seen in patients with PCOS than in normal patients. We aimed at evaluating the distribution of Apo E alleles that can influence cardiovascular risk of the PCOS patients and control subjects.
  
  
  METHODS
  In this study, 129 young women with PCOS and 91 healthy women were included. In all subjects we performed hormonal, biochemical and Apo E genetic analysis.
  
  
  RESULTS
  The Apo E3 allele was found at a significantly higher frequency in the PCOS patient group compared with the control group. The Apo E2 allele was found at a significantly higher frequency in the control group compared with the patient group with PCOS.
  
  
  CONCLUSIONS
  Although there were genotype and allele differences between control and patient groups in this study, no statistically significant change was determined in lipid and other cardiovascular risk factors in connection with allele and genotype.
authors.affiliation: Department of Endocrinology and Metabolism Disease, Division of Internal Medicine, Ege University Hospital, Izmir, Turkey.
authors.forename: Sevki
authors.initials: S
authors.lastname: Cetinkalp
authors.forename: Muammer
authors.initials: M
authors.lastname: Karadeniz
authors.forename: Mehmet
authors.initials: M
authors.lastname: Erdogan
authors.forename: Ayhan
authors.initials: A
authors.lastname: Zengi
authors.forename: Vildan
authors.initials: V
authors.lastname: Cetintas
authors.forename: Asli
authors.initials: A
authors.lastname: Tetik
authors.forename: Zuhal
authors.initials: Z
authors.lastname: Eroglu
authors.forename: Buket
authors.initials: B
authors.lastname: Kosova
authors.forename: A Gokhan
authors.initials: AG
authors.lastname: Ozgen
authors.forename: Fusun
authors.initials: F
authors.lastname: Saygili
authors.forename: Candeger
authors.initials: C
authors.lastname: Yilmaz
mesh_terms: D000328:Adult; D001057:Apolipoproteins E / Q000235:genetics*; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D011388:Prolactin / Q000097:blood; D012307:Risk Factors; D017422:Sequence Analysis, DNA; D014421:Turkey / Q000453:epidemiology
chemical_list: D001057:Apolipoproteins E; D011388:Prolactin; D007986:Luteinizing Hormone