An outstanding palladium system containing a C2-symmetrical phosphite ligand for enantioselective allylic substitution processes.
The use of efficient Pd systems bearing C(2)-symmetric chiral diphosphite ligands derived from carbohydrates in asymmetric allylic substitution reactions is described here, reaching TOFs > 22 000 h(-1) in allylic alkylation and ca. 400 h(-1) in allylic amination, giving excellent enantioselectivities (ee > 99%) and kinetic resolution of the racemic substrate.
Balanta Castillo
Angelica
A
Departament de Química Física i Inorgànica, Universitat Rovira i Virgili, C/Marcel.li Domingo s/n 43007 Tarragona, Spain.
Favier
Isabelle
I
Teuma
Emmanuelle
E
Castillón
Sergio
S
Godard
Cyril
C
Aghmiz
Ali
A
Claver
Carmen
C
Gómez
Montserrat
M