title: Whole-procedure clinical accuracy of gamma knife treatments of large lesions.
abstract: The mechanical accuracy of Gamma Knife radiosurgery based on single-isocenter measurement has been established to within 0.3 mm. However, the full delivery accuracy for Gamma Knife treatments of large lesions has only been estimated via the quadrature-sum analysis. In this study, the authors directly measured the whole-procedure accuracy for Gamma Knife treatments of large lesions to examine the validity of such estimation. The measurements were conducted on a head-phantom simulating the whole treatment procedure that included frame placement, computed tomography imaging, treatment planning, and treatment delivery. The results of the measurements were compared with the dose calculations from the treatment planning system. Average agreements of 0.1-1.6 mm for the isodose lines ranging from 25% to 90% of the maximum dose were found despite potentially large contributing uncertainties such as 3-mm imaging resolution, 2-mm dose grid size, 1-mm frame registration, multi-isocenter deliveries, etc. The results of our measurements were found to be significantly smaller (>50%) than the calculated value based on the quadrature-sum analysis. In conclusion, Gamma Knife treatments of large lesions can be delivered much more accurately than predicted from the quadrature-sum analysis of major sources of uncertainties from each step of the delivery chain.
authors.affiliation: Department of Radiation Oncology, University of California San Francisco, San Francisco, California 94143, USA. lijunma@radonc.ucsf.edu
authors.forename: Lijun
authors.initials: L
authors.lastname: Ma
authors.forename: Cynthia
authors.initials: C
authors.lastname: Chuang
authors.forename: Martina
authors.initials: M
authors.lastname: Descovich
authors.forename: Paula
authors.initials: P
authors.lastname: Petti
authors.forename: Vernon
authors.initials: V
authors.lastname: Smith
authors.forename: Lynn
authors.initials: L
authors.lastname: Verhey
mesh_terms: D001932:Brain Neoplasms / Q000473:pathology / Q000601:surgery; D006801:Humans; D008579:Meningioma / Q000601:surgery; D009362:Neoplasm Metastasis; D019047:Phantoms, Imaging; D011829:Radiation Dosage; D016634:Radiosurgery / Q000295:instrumentation* / Q000379:methods*; D012680:Sensitivity and Specificity; D035501:Uncertainty