title: [A case of acute pancreatitis induced by multiple drugs in a patient with ulcerative colitis].
abstract: Acute pancreatitis is a serious disease with fatality rate up to 15%. We recently experienced a case of acute pancreatitis induced by multiple drugs in a patient with ulcerative colitis. A 20-year-old female visited with abdominal pain and hematochezia and diagnosed of ulcerative colitis. Sulfasalazine and prednisolone were used. However, acute pancreatitis occurred after 4 weeks of treatment with additional azathioprine treatment. Drug-induced pancreatitis was suspected, and she was recovered with conventional therapy for acute pancreatitis. Therefore, it was proposed that acute pancreatitis was induced by azathioprine. However, after the administration of sulfasalazine, pancreatitis relapsed. Furthermore, even the re-administration of 5-ASA and azathioprine induced relapse of acute pancreatitis. We concluded that acute pancreatitis was induced by multiple drugs in this patient with ulcerative colitis.
authors.affiliation: Department of Internal Medicine, Hanyang University Hospital, Seoul, Korea.
authors.forename: Chang Nam
authors.initials: CN
authors.lastname: Son
authors.forename: Hang Lak
authors.initials: HL
authors.lastname: Lee
authors.forename: Yong Won
authors.initials: YW
authors.lastname: Joo
authors.forename: Oh Young
authors.initials: OY
authors.lastname: Lee
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Han
authors.forename: Byung Chul
authors.initials: BC
authors.lastname: Yoon
authors.forename: Ho Soon
authors.initials: HS
authors.lastname: Choi
authors.forename: Joon Soo
authors.initials: JS
authors.lastname: Hahm
mesh_terms: D000208:Acute Disease; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D000963:Antimetabolites / Q000009:adverse effects; D001379:Azathioprine / Q000009:adverse effects; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000188:drug therapy*; D003113:Colonoscopy; D005260:Female; D006801:Humans; D019804:Mesalamine / Q000009:adverse effects; D010195:Pancreatitis / Q000139:chemically induced* / Q000175:diagnosis*; D012460:Sulfasalazine / Q000009:adverse effects; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000963:Antimetabolites; D012460:Sulfasalazine; D019804:Mesalamine; D001379:Azathioprine