Possible novel targets for therapeutic angiogenesis.
An increasing number of studies about the molecular basis of angiogenesis are rapidly disclosing novel signal pathways involved in the blood vessel formation process. This review will focus on bone morphogenic proteins, Hedgehog, Notch, ephrins, neuropilins, neurotrophins and netrins. These recently discovered angiogenesis mediators are involved in vascular development during embryogenesis and, interestingly, they are shared between the nervous and vascular systems. They represent new potential targets in the vasculature and suggest novel therapeutic opportunities.
Cristofaro
Brunella
B
Division of Experimental Cardiovascular Medicine, Bristol Heart Institute, University of Bristol, Bristol, UK.
Emanueli
Costanza
C
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000502:physiology; D016503:Drug Delivery Systems; D036342:Ephrins / Q000502:physiology; D053823:Hedgehog Proteins / Q000502:physiology; D006801:Humans; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D018919:Neovascularization, Physiologic / Q000502:physiology*; D009414:Nerve Growth Factors / Q000502:physiology; D000075388:Netrin-1; D039921:Neuropilins / Q000502:physiology; D036081:Receptors, Eph Family / Q000502:physiology; D051880:Receptors, Notch / Q000502:physiology; D025521:Tumor Suppressor Proteins / Q000502:physiology
D020533:Angiogenesis Inhibitors; D019485:Bone Morphogenetic Proteins; D036342:Ephrins; D053823:Hedgehog Proteins; D009414:Nerve Growth Factors; D039921:Neuropilins; D051880:Receptors, Notch; D025521:Tumor Suppressor Proteins; D000075388:Netrin-1; D036081:Receptors, Eph Family