Synthesis of telluroamino acid derivatives with remarkable GPx like activity.
A series of modular telluroamino acid derivatives with remarkable GPx-like behavior was prepared in an efficient and short two-step synthesis.
Braga
Antonio L
AL
Departamento de Química, Universidade Federal de Santa Maria, 97.105-900, Santa Maria, RS, Brazil. albraga@quimica.ufsm.br
Alberto
Eduardo E
EE
Soares
Letiére C
LC
Rocha
João B T
JB
Sudati
Jéssie H
JH
Roos
Daniel H
DH
D000596:Amino Acids / Q000008:administration & dosage* / Q000737:chemistry; D000975:Antioxidants / Q000737:chemistry; D001393:Azoles / Q000737:chemistry; D002384:Catalysis; D002621:Chemistry / Q000379:methods; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006861:Hydrogen Peroxide / Q000737:chemistry; D054833:Isoindoles; D008956:Models, Chemical; D016566:Organoselenium Compounds / Q000737:chemistry; D012643:Selenium / Q000737:chemistry
D000596:Amino Acids; D000975:Antioxidants; D001393:Azoles; D054833:Isoindoles; D016566:Organoselenium Compounds; C042986:ebselen; D006861:Hydrogen Peroxide; D005979:Glutathione Peroxidase; D005978:Glutathione; D012643:Selenium