title: Dietary patterns and risk of cancer: a factor analysis in Uruguay.
abstract: A multisite case-control study on factor analysis and several cancer sites (mouth and pharynx, esophagus, stomach, colon, rectum, larynx, lung, breast, prostate, bladder, kidney) was conducted in Uruguay. The study included 3,528 cases and 2,532 controls. Factor analysis (principal components) was modeled among controls. This patterning method retained 4 factors per sex, labeled as prudent, drinker, traditional and Western. Odds ratios for these cancer sites, stratified by sex, were estimated using polytomous regression. Whereas the prudent pattern was mainly negatively associated with cancers of the upper aerodigestive tract, the Western pattern showed a strong increase in breast, lung and colon cancers. The study allowed for the reproducibility of the prudent, drinker and Western patterns, whereas the traditional pattern appears to be country specific.
authors.affiliation: Departamento de Anatomía Patológica, Grupo de Epidemiología, Universidad de Clínicas, Facultad de Medicina, Montevideo, Uruguay. estefani@adinet.com.uy
authors.forename: Eduardo
authors.initials: E
authors.lastname: De Stefani
authors.forename: Hugo
authors.initials: H
authors.lastname: Deneo-Pellegrini
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
authors.forename: Alvaro L
authors.initials: AL
authors.lastname: Ronco
authors.forename: Dagfinn
authors.initials: D
authors.lastname: Aune
authors.forename: Gisele
authors.initials: G
authors.lastname: Acosta
authors.forename: María
authors.initials: M
authors.lastname: Mendilaharsu
authors.forename: Paul
authors.initials: P
authors.lastname: Brennan
authors.forename: Gilles
authors.initials: G
authors.lastname: Ferro
mesh_terms: D000428:Alcohol Drinking; D001943:Breast Neoplasms / Q000453:epidemiology; D004032:Diet; D005163:Factor Analysis, Statistical; D005247:Feeding Behavior / Q000145:classification; D005260:Female; D006801:Humans; D015994:Incidence; D007407:Interviews as Topic; D008297:Male; D009369:Neoplasms / Q000453:epidemiology*; D016017:Odds Ratio; D011471:Prostatic Neoplasms / Q000453:epidemiology; D012044:Regression Analysis; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014583:Uruguay / Q000453:epidemiology