title: [A prospective study on nerve-sparing radical hysterectomy in patients with cervical cancer].
abstract: OBJECTIVE
  To assess the nerve-sparing radical hysterectomy (NSRH) technique and its impact on postoperative voiding function.
  
  
  METHODS
  Forty-four patients with International Federation of Gynecology and Obstetrics (FIGO) stage I b1-IIa cervical cancer were enrolled and randomized into NSRH group (study group, n = 22) and conventional radical hysterectomy (CRH) group (control group, n = 22). The pelvic autonomic nerve pathway (including hypogastric nerve, pelvic splanchnic nerve, inferior hypogastric plexus and bladder branch) was completely preserved in the NSRH group. Related parameters were compared between the two groups.
  
  
  RESULTS
  The estimated blood loss in NSRH group and CRH group were (550 +/- 241) ml and (475 +/- 284) ml, respectively, with no significant difference (P > 0.05). The mean operation time in NSRH group and CRH group were (329 +/- 43) min and (272 +/- 56) min, respectively, with a significant difference (P < 0.01). More patients in NSRH group had post-void residual urine volume (PVR) < 100 ml than that in CRH group on day 8 after surgery (68% vs. 18%, P < 0.01). The median duration of postoperative catheterization was significantly shorter in NRSH group (8 - 23 days, median 8 days) than that in CRH group (8 - 32 days, median 20 days; P < 0.01). Neither surgery-related injury nor pathologically positive margin was reported in either of the groups.
  
  
  CONCLUSIONS
  NSRH is a feasible and safe technique for preserving bladder function. Larger prospective studies are needed to confirm the efficacy of this technique.
authors.affiliation: Department of Gynecological Oncology, Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100021, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.forename: Rong
authors.initials: R
authors.lastname: Zhang
authors.forename: Ling-Ying
authors.initials: LY
authors.lastname: Wu
authors.forename: Gong-Yi
authors.initials: GY
authors.lastname: Zhang
authors.forename: Xian
authors.initials: X
authors.lastname: Li
authors.forename: Gao-Zhi
authors.initials: GZ
authors.lastname: Yu
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery*; D002584:Cervix Uteri / Q000294:innervation / Q000601:surgery; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007001:Hypogastric Plexus / Q000033:anatomy & histology / Q000601:surgery; D007044:Hysterectomy / Q000379:methods*; D008197:Lymph Node Excision; D008875:Middle Aged; D009367:Neoplasm Staging; D010388:Pelvis / Q000294:innervation*; D011183:Postoperative Complications / Q000517:prevention & control; D011446:Prospective Studies; D013153:Splanchnic Nerves / Q000033:anatomy & histology / Q000601:surgery; D016896:Treatment Outcome; D001743:Urinary Bladder / Q000294:innervation*; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery*