title: Prospective analysis of traffic exposure as a risk factor for incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study.
abstract: BACKGROUND
  For people living close to busy roads, traffic is a major source of air pollution. Few prospective data have been published on the effects of long-term exposure to traffic on the incidence of coronary heart disease (CHD).
  
  
  OBJECTIVE
  In this article, we examined the association between long-term traffic exposure and incidence of fatal and nonfatal CHD in a population-based prospective cohort study.
  
  
  METHODS
  We studied 13,309 middle-age men and women in the Atherosclerosis Risk in Communities study, without previous CHD at enrollment, from 1987 to 1989 in four U.S. communities. Geographic information system-mapped traffic density and distance to major roads served as measures of traffic exposure. We examined the association between traffic exposure and incident CHD using proportional hazards regression models, with adjustment for background air pollution and a wide range of individual cardiovascular risk factors.
  
  
  RESULTS
  Over an average of 13 years of follow-up, 976 subjects developed CHD. Relative to those in the lowest quartile of traffic density, the adjusted hazard ratio (HR) in the highest quartile was 1.32 [95% confidence interval (CI), 1.06-1.65; p-value for trend across quartiles = 0.042]. When we treated traffic density as a continuous variable, the adjusted HR per one unit increase of log-transformed density was 1.03 (95% CI, 1.01-1.05; p = 0.006). For residents living within 300 m of major roads compared with those living farther away, the adjusted HR was 1.12 (95% CI, 0.95-1.32; p = 0.189). We found little evidence of effect modification for sex, smoking status, obesity, low-density lipoprotein cholesterol level, hypertension, age, or education.
  
  
  CONCLUSIONS
  Higher long-term exposure to traffic is associated with incidence of CHD, independent of other risk factors. These prospective data support an effect of traffic-related air pollution on the development of CHD in middle-age persons.
authors.affiliation: Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA.
authors.forename: Haidong
authors.initials: H
authors.lastname: Kan
authors.forename: Gerardo
authors.initials: G
authors.lastname: Heiss
authors.forename: Kathryn M
authors.initials: KM
authors.lastname: Rose
authors.forename: Eric A
authors.initials: EA
authors.lastname: Whitsel
authors.forename: Fred
authors.initials: F
authors.lastname: Lurmann
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: London
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000453:epidemiology*; D003327:Coronary Disease / Q000453:epidemiology*; D006801:Humans; D011446:Prospective Studies; D012307:Risk Factors; D014481:United States; D001335:Vehicle Emissions / Q000633:toxicity*
chemical_list: D001335:Vehicle Emissions