Paraneoplastic leukocytoclastic vasculitis.
Widespread eruptive purpura, hematuria and proteinuria developed in a 56-year-old woman. A skin biopsy showed leukocytoclastic vasculitis. During a 31-month follow-up, the purpura repeatedly cleared with corticosteroid treatment only to flare with tapering of the medication. Awareness of possible cancer-associated vasculitis led us to search for an occult malignancy, and an asymptomatic lung tumor was discovered. During a 32-month observation period, after resection of a well differentiated peripheral pulmonary adenocarcinoma, the purpuric skin eruption did not recur, although steroid therapy was withheld.
Rozenbaum
M
M
Rheumatology Service (M.R., I.R.), Department of Medicine A (J.E.N.) and Department of Pathology (I.M., J.H.B.), Bnai-Zion Medical Center and the Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.
Naschitz
J E
JE
Rosner
I
I
Misselevich
I
I
Boss
J H
JH