title: Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome.
abstract: The purpose of the present study was to identify genetic variants that confer susceptibility to chronic kidney disease (CKD) in Japanese individuals with metabolic syndrome. The study population comprised 2150 Japanese individuals with metabolic syndrome, including 411 subjects with CKD [estimated glomerular filtration rate (eGFR) <50 mL/min/1.73m(2)] and 1739 controls (eGFR >/=60 mL/min/1.73m(2)). The genotypes for 100 polymorphisms of 80 candidate genes were determined. The chi-square test, multivariable logistic regression analysis with adjustment for covariates, as well as a stepwise forward selection procedure revealed that nine polymorphisms of APOE, ABCA1, PTGS1, TNF, CPB2, AGTR1, OR13G1, and GNB3 were associated (P<0.05) with the prevalence of CKD. Among these polymorphisms, the -219G-->T polymorphism of APOE (rs405509) was most significantly associated with CKD in Japanese individuals with metabolic syndrome.
authors.affiliation: Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Japan.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Yoshida
authors.forename: Kimihiko
authors.initials: K
authors.lastname: Kato
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Fujimaki
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Yokoi
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Oguri
authors.forename: Sachiro
authors.initials: S
authors.lastname: Watanabe
authors.forename: Norifumi
authors.initials: N
authors.lastname: Metoki
authors.forename: Hidemi
authors.initials: H
authors.lastname: Yoshida
authors.forename: Kei
authors.initials: K
authors.lastname: Satoh
authors.forename: Yukitoshi
authors.initials: Y
authors.lastname: Aoyagi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nishigaki
authors.forename: Masashi
authors.initials: M
authors.lastname: Tanaka
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Nozawa
authors.forename: Yoshiji
authors.initials: Y
authors.lastname: Yamada
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000208:ethnology / Q000235:genetics; D008875:Middle Aged; D011110:Polymorphism, Genetic; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000235:genetics
chemical_list: D001057:Apolipoproteins E