title: Aminoacid-derived mercaptoimidazoles.
abstract: Starting from suitably protected amino acids, mercaptoimidazoles were synthesized either from the acid or including the amine nitrogen itself. A preliminary optimisation study led to efficient conditions for the obtention of the imidazole ring. These conditions are compatible with the presence of amino acid or dipeptide scaffolds.
authors.affiliation: Val-de-Pharm, Parc industriel d'Incarville, BP 606, 27106, Val-de-Reuil Cedex, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Crépin
authors.forename: Nicolas
authors.initials: N
authors.lastname: Wattier
authors.forename: Sylvain
authors.initials: S
authors.lastname: Petit
authors.forename: Laurent
authors.initials: L
authors.lastname: Bischoff
authors.forename: Corinne
authors.initials: C
authors.lastname: Fruit
authors.forename: Francis
authors.initials: F
authors.lastname: Marsais
mesh_terms: D000143:Acids / Q000737:chemistry*; D020816:Amino Acid Motifs; D000596:Amino Acids / Q000737:chemistry*; D002625:Chemistry, Organic / Q000379:methods*; D004220:Disulfides / Q000737:chemistry; D006868:Hydrolysis; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D008670:Metals / Q000737:chemistry; D008956:Models, Chemical; D010447:Peptide Hydrolases / Q000737:chemistry; D010455:Peptides / Q000737:chemistry; D017434:Protein Structure, Tertiary
chemical_list: D000143:Acids; D000596:Amino Acids; D004220:Disulfides; D007093:Imidazoles; D008670:Metals; D010455:Peptides; D010447:Peptide Hydrolases