Heritability of P. falciparum and P. vivax malaria in a Karen population in Thailand.
The majority of studies concerning malaria host genetics have focused on individual genes that confer protection against rather than susceptibility to malaria. Establishing the relative impact of genetic versus non-genetic factors on malaria infection and disease is essential to focus effort on key determinant factors. This relative contribution has rarely been evaluated for Plasmodium falciparum and almost never for Plasmodium vivax. We conducted a longitudinal cohort study in a Karen population of 3,484 individuals in a region of mesoendemic malaria, Thailand from 1998 to 2005. The number of P. falciparum and P. vivax clinical cases and the parasite density per person were determined. Statistical analyses were performed to account for the influence of environmental factors and the genetic heritability of the phenotypes was calculated using the pedigree-based variance components model. The genetic contribution to the number of clinical episodes resulting from P. falciparum and P. vivax were 10% and 19% respectively. There was also moderate genetic contribution to the maximum and overall parasite trophozoite density phenotypes for both P. falciparum (16%&16%) and P. vivax (15%&13%). These values, for P. falciparum, were similar to those previously observed in a region of much higher transmission intensity in Senegal, West Africa. Although environmental factors play an important role in acquiring an infection, genetics plays a determinant role in the outcome of an infection with either malaria parasite species prior to the development of immunity.
Phimpraphi
Waraphon
W
Laboratoire de la Génétique de la Réponse aux Infections Chez l'Homme, Institut Pasteur, Paris, France.
Paul
Richard
R
Witoonpanich
Bhee
B
Turbpaiboon
Chairat
C
Peerapittayamongkol
Chayanon
C
Louicharoen
Chalisa
C
Casademont
Isabelle
I
Tungpradabkul
Sumalee
S
Krudsood
Srivicha
S
Kaewkunwal
Jaranit
J
Sura
Thanyachai
T
Looareesuwan
Sornchai
S
Singhasivanon
Pratap
P
Sakuntabhai
Anavaj
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001788:Blood Grouping and Crossmatching; D002648:Child; D002675:Child, Preschool; D004375:Duffy Blood-Group System; D004777:Environment; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D040582:Inheritance Patterns / Q000235:genetics*; D016778:Malaria, Falciparum / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D016780:Malaria, Vivax / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D010963:Plasmodium falciparum / Q000235:genetics*; D010966:Plasmodium vivax / Q000235:genetics*; D013785:Thailand / Q000453:epidemiology
D004375:Duffy Blood-Group System