title: [Oxidative stress: a review on metabolic signaling in type 1 diabetes].
abstract: Diabetic complications appear to be multifactorial process. The biochemical and pathological mechanisms are associated with chronic hyperglycemia of diabetes and the increased oxidative stress which has been postulated to play a central role in these disorders. Accumulating evidence suggests that oxidative cell injury caused by free radicals contributes to the development of type 1 diabetes (DM1) complications and decreased efficiency of antioxidant defenses (both enzymatic and nonenzymatic) seems to correlate with the severity of pathological tissue changes in DM1. In this review, we report as oxidative stress may exert deleterious effects in diabetes, as well as address current strategies in study to down-regulating vascular injury.
authors.affiliation: Núcleo de Pesquisa e Pós-graduação, Santa Casa de Belo Horizonte, Belo Horizonte, MG. janicesepulveda@terra.com.br
authors.forename: Janice Sepúlveda
authors.initials: JS
authors.lastname: Reis
authors.forename: Clara Araújo
authors.initials: CA
authors.lastname: Veloso
authors.forename: Rafael Teixeira
authors.initials: RT
authors.lastname: Mattos
authors.forename: Saulo
authors.initials: S
authors.lastname: Purish
authors.forename: José Augusto
authors.initials: JA
authors.lastname: Nogueira-Machado
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D001669:Biochemical Phenomena; D048909:Diabetes Complications / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000150:complications; D018384:Oxidative Stress / Q000502:physiology*; D011493:Protein Kinase C / Q000502:physiology
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D011493:Protein Kinase C