A natural carbohydrate substrate for Mycobacterium tuberculosis methionine sulfoxide reductase A.
Enzymatic reduction of the methylsulfinylxylofuranosyl (MSX) groups in lipoarabinomannan provides proof of the absolute configuration of MSX and a possible biochemical mechanism for oxidative protection in Mycobacterium tuberculosis.
Stalford
Susanne A
SA
Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UKLS2 9JT.
Fascione
Martin A
MA
Sasindran
Smitha J
SJ
Chatterjee
Delphi
D
Dhandayuthapani
Subramanian
S
Turnbull
W Bruce
WB
D002241:Carbohydrates / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry; D008070:Lipopolysaccharides / Q000737:chemistry*; D051150:Methionine Sulfoxide Reductases; D009169:Mycobacterium tuberculosis / Q000201:enzymology*; D016877:Oxidants / Q000737:chemistry; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000737:chemistry*; D017382:Reactive Oxygen Species; D013237:Stereoisomerism; D013379:Substrate Specificity
D002241:Carbohydrates; D008070:Lipopolysaccharides; D016877:Oxidants; D017382:Reactive Oxygen Species; C050016:lipoarabinomannan; D006861:Hydrogen Peroxide; D010088:Oxidoreductases; D051150:Methionine Sulfoxide Reductases; C027219:methionine sulfoxide reductase